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Sample records for corionica humana hcg

  1. Anticuerpos monoclonales contra la Gonadotropina Corionica Humana (HCG y su empleo en el diagnóstico precoz del embarazo.

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    Torres E

    2006-03-01

    Full Text Available Se describe la obtención y caracterización de anticuerpos monoclonales contra la hormona gonadotropina cariónica humana (HCG, seleccionados de la inmunización subcutánea en ratones BALB/c. Se reporta también el desarrollo del sistema rápido HeberFast Line® Embarazo, para la detección de la hormona en muestras de orina, basado en los anticuerpos obtenidos y la tecnología del flujo lateral desarrollada en membranas de nitrocelulosa como soporte sólido. El nivel de sensibilidad alcanzado con este sistema diagnóstico es de 20 UI/L de HCG en muestra de orina, y no se observó reactividad cruzada en analitos similares conteniendo concentraciones de las glicohormonas relacionadas; 1000 IU de LH, 5000 IU de FSH, y 1000 µIU de TSH respectivamente. Los estudios de estabilidad arrojaron, que el diagnosticador mantine las características de funcionalidad por un tiempo de 15 meses a temperaturas entre 2 y 30 ºC, conformando este el tiempo de vigencia del sistema. De poseer en Farmacias, Consultorios Médicos de la Familia y Hospital Gineco-Obstétricos, un sistema rápido y sencillo como el establecido en este trabajo, se pueden evitar todos los riesgos e inconvenientes que acarrean los procesos de interrupción del embarazo en la mujer.

  2. Localización inmunocitoquímica de la hormona gonadotropina corionica en la placenta humana y en celulas tumorales

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    Geranina Escovar V.

    1982-06-01

    Full Text Available Mediante el uso de los métodos de peroxidasa anti-peroxidasa e inmunofluorescencia aplicada a tejidos desparafinados y tratados con tripsina, se estudiaron inmunocitoquímicamente un grupo de placentas y tumores malignos. Al utilizar anticuerpos anti-GCH, la hormona gonadotropina coriónica humana (GCH fue localizada en células del sincitiotrofoblasto de placentas de diferentes estados de desarrollo, se encontró, además, que las c6lulas de Langhan's y del citotrofoblasto fueron negativas a la inmuno-reacción. La mayoría de los tumores estudiados fueron encontrados positivos al aplicar los métodos mencionados. Se postula que la inmunosupresión selectiva del huésped por tumores y la inmunosupresión selectiva de tejidos maternos por tejidos fetales. podría estar mediada por la hormona gonadotropina coriónica.

  3. Purificación de la hormona Gonadotropina Coriónica humana (HCG por cromatografía de inmunoafinidad.

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    Dayami Dorta Hernández

    2006-06-01

    Full Text Available En el presente trabajo se repota la purificación de la hormona Gonadotropina Coriónica Humana (HCG a escala experimental, a partir de concentrados de orina de mujeres gestales, utilizando el método de inmunopurificación por cromatografía de afinidad. Para ello se acoplaron convalentemente anticuerpos monoclonales específicos por la subunidad ß de la HCG a polímeros de Sefarosa CL 4B activada con Bromuro de Cianógeno (PHARMACIA, Suecia. Se logró aislar la glicoproteína HCG con más de un 95 % de pureza, utilizando KSCN 3M como tampón de elución. La proteína obtenida mantuvo su actividad natural, determinada por Dipstick Cromatográfico y análisis por Western-blot.

  4. Anticuerpos monoclonales contra la gonadotropina coriónica humana (hCG para su uso en la detección de embarazo Monoclonal antibodies against human chorionic gonadotropin (HCG for their use in pregnancy detection

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    Bertha V. Rodríguez Pendás

    2004-12-01

    Full Text Available Se reporta la generación de 2 anticuerpos monoclonales (AcM de ratón dirigidos contra la hormona gonadotropina coriónica humana (hCG, a partir de la inmunización de ratones BALB/c con hCG humana, purificada en el Instituto Nacional de Endocrinología (INEN. Los AcM obtenidos son de la clase IgG y fueron purificados a partir de líquido ascítico, mediante cromatografía de afinidad en proteína G Sepharosa. El estudio de afinidad y especificidad demostró que estos anticuerpos podían ser útiles en ensayos inmunoenzimáticos, con el uso de uno de ellos en el sistema microELISA, de nuestra institución, para la detección cualitativa de embarazo en orina.The generation of 2 mouse monoclonal antibodies directed against the human chorionic gonadotropin hormone (CGh, starting from the immunization of BALB/c mice with human CGh purified at the National Institute of Endocrinology (NIEN is reported. IgG monoclonal antibodies were obtained. They were purified starting from the ascitic fluid by affinity chromatography in protein G Sepharose. The affinity and specificity study showed that these antibodies could be useful in immunoenzimatic assays, using one of them in the microELISA system of our institution for the qualitative detection of pregnancy in urine.

  5. Analysis of recombinant and native human lutropin/luteotrophin and human chorionic gonadotropin by reversed-phase high performance liquid chromatography; Analise de luteotrofina humana e de gonadotrofina corionica humana, recombinante e natural, por cromatografia liquida de alta eficiencia em fase reversa

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Beatriz Elane de

    2009-07-01

    Specific RP-HPLC conditions for the analysis of recombinant and native hLH and hCG preparations and of their subunits were set up. Heterodimeric hLH and hCG and their alpha and beta subunits all migrated with significantly different retention times (t{sub R}) in the following order of increasing hydrophobicity: alpha-hCG < alpha-hLH < hCG < hLH < -beta-hCG < beta-hLH. With basis on these conditions, a total of eleven preparations were studied: the International Standard of recombinant hLH-WHO 96/602, a commercial recombinant and two highly purified pituitary hLH, a recombinant and two urinary hCG preparations and four heterogeneous urinary products containing hLH + hFSH. All hLH preparations showed very similar retention times for the main peak (t{sub R} = 38.35 +- 0.42 min; RSD = 1.1 %; n = 4 preparations), while the hCG main peak ran about 4 % faster when compared to this average value. Human LH, hFSH and hCG peaks could also be identified in the heterogeneous urinary preparations. Quantitative analysis could be validated for the seven homogeneous preparations and accuracy, precision and sensitivity were calculated on the basis of a highly linear dose-response curve (r=0.99998; p<0.0001; n=20). Quantification of the different gonadotropins in the heterogeneous urinary preparations was also carried out, though with clear accuracy limitations. (author)

  6. Validación de un juego de reactivos (CUALINEN-HCG para la detección cualitativa de gonadotropina coriónica humana en el embarazo Validation of a kit of reagents (CUALINEN-HCG for the qualitative detection of human chorionic gonadotropin in pregnancy

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    Gema E. García Dafonte

    2002-12-01

    Full Text Available Se presentaron los resultados de la estandarización de un juego de reactivos (CUALINEN-HCG para la detección de la gonadotropina coriónica humana (HCG en muestras de orina de mujeres embarazadas y de su validación diagnóstica en el nivel primario. CUALINEN-HCG es un microELISA de doble captura, que cuenta con un anticuerpo monoclonal específico para la subunidad b de la hCG (AcM-b hCG-IG1 y de conjugados enzimáticos con el sustrato colorimétrico correspondiente, obtenido y purificado en el Instituto Nacional de Endocrinología. Los resultados de la validación analítica del CUALINEN-HCG mostraron que era capaz de distinguir entre muestras de orinas positivas y negativas con una relación positivo/negativo de 10 veces; se obtuvieron coeficientes de variación del 6 % en estudios de precisión (interensayos e intraensayos realizados para el control positivo. Se procesaron 91 muestras de orina matutina de mujeres con amenorrea de entre 4 y 16 sem a partir de la última fecha de menstruación. En las que el embarazo fue diagnosticado posteriormente. Se logró la validación en el nivel primario del CUALINEN-HCG con una sensibilidad y especificidad diagnóstica de 85 y 95 %, respectivamente y una exactitud diagnóstica del 90 %. Se recomendó su uso como herramienta auxiliar para el diagnóstico del embarazo en nivel primario a partir de la primera semana de ausencia de la menstruación (5 sem de amenorrea.The results of the standardization of a Kit of reagents (CUALINEN-HCG, for the detection of the Human Chorionic Gonadotropin (HCG in urine and their diagnostic validation at primary level are presented. CUALINEN-HCG is a double capture micro ELISA that involves the participation of a specific monoclonal antibody for the b subunit of the hCG (AcM-bhCG-IG1 and the enzymatic conjugated with the corresponding colorimetric substrate, obtained and purified in the National Institute of Endocrinology. The results of the analytic validation of the

  7. Indução da ovulação em vacas com gonadotrofina coriônica humana (hCG purificada por cromatografia de afinidade

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    Claudia Maria Bertan

    2006-06-01

    Full Text Available Objective of the present study was to purify hCG contained in commercial preparation (Pregnyl® - Organon by affinity chromatography and to evaluate ovulation rates in cows injected with the purified hormone. A chromatography column containing concanavalin-A sepharose (Con-A matrix was equilibrated and one hundred thousand international units (UI of Pregnyl® were applied to the column. Fractions of 3,8µL were collected (4°C every 5 minutes for 12,5h, to yield a total of 150 fractions. After fraction 76, a column buffer containing 0,3M ±-methylglicoside was added to the column. Protein concentrations were estimated by espectrophotometry (280nm. Two peaks of absorbance were observed, between fractions 14 and 19, and fractions 90 and 100. Fractions 14-19 and 90-150 were sequentially grouped in pairs concentrated by ultrafiltration and analyzed by SDS-PAGE. The first peak of absorbance resulted from proteins contained in the commercial product, eluted from the column and not adsorbed by the Con-A matrix. The second peak represented proteins adsorbed by the column, especially hCG. The fractions containing hCG were grouped in a single sample and protein concentration was measured by the Lowry method. Cows in day 5 of the estral cycle, which had a dominant follicle larger than 8mm, were injected with 0,1, 0,2 or 0,3mg protein of the purificated sample. The ovulation rate 48 hours after treatment was 0%, 50% and 75%, respectively. It was demonstrated that relative concentration of hCG can be increased by affinity chromatography and biological activity of purified hCG was satisfactory preserved.

  8. Characterization of a transgenic mouse model that hypersecretes hCG and develops gonadal tumours

    OpenAIRE

    Gonzalez, Betina

    2010-01-01

    En esta Tesis Doctoral se estudiaron distintos aspectos de la regulación del eje hipotálamo-hipófiso-gonadal (HHG) en un modelo de ratones transgénicos que produce niveles elevados de la hormona gonadotrofina coriónica humana (hCG) y desarrolla tumores gonadales (ratones hCGDE+). Se partió de la hipótesis que los elevados niveles de esteroides sexuales inducidos por la hipersecreción de hCG desde edades tempranas del desarrollo, actuarían sobre el eje HHG alterando la síntesis y secreción de ...

  9. Intact HCG, free HCG beta subunit and HCG beta core fragment: longitudinal patterns in urine during early pregnancy

    National Research Council Canada - National Science Library

    McChesney, Ruth; Wilcox, Allen J; O'Connor, John F; Weinberg, Clarice R; Baird, Donna D; Schlatterer, John P; McConnaughey, D Robert; Birken, Steven; Canfield, Robert E

    2005-01-01

    Detecting and monitoring early pregnancy depend on the measurement of HCG. Little is known about how production of various forms of HCG may evolve over the earliest weeks of pregnancy, particularly in naturally conceived pregnancies...

  10. Atomic Gas Distribution in HCG31 and HCG92

    Science.gov (United States)

    Borthakur, Sanchayeeta; Yun, M.; Verdes-Montenegro, L.; Heckman, T. M.; Zhu, G.

    2014-01-01

    We present Green Bank Telescope (GBT) 5x5 grid observations surrounding the actively star forming groups Hickson Compact Group, HCG 31 and HCG 92. We find that the total HI content of the groups are 2x10^10 and 2.5x10^10 solar masses respectively. The HI in HCG31 is mostly associated with the central region, however, there is a faint extension of the order of 10^9 solar masses of gas toward the southeast direction detected at the GBT pointing centered at a distance of 185 kpc from the group center. The velocity range of the HI is similar to the HI in the central pixel indicating its kinematic link to the gas in the center of the group. HCG 92 shows strong HI emission at a position of a pointing 4' offset from the center. The ``HI-wing" at velocities 6350-6500 km/s (Borthakur et al. 2010) were found to be confined to a few pointings adjacent to the peak suggesting that the wing as is localized and not extended. However, this must be gas stripped due to interactions and are dynamically connected to the Arc-N (Williams et al. 2002). We comment on the survival of the gas from the ionizing photons of the metagalactic ultraviolet background and those produced by the starburst. The implication of the existence of an HI rich environments surrounding the starbursts support the possibility of continued and future star formation in these groups.

  11. IGF-II Y LA GONADOTROPINA CORIONICA REGULAN LA PROLIFERACION, MIGRACION E INVASION DE CELULAS DE TROFOBLASTO HUMANO

    National Research Council Canada - National Science Library

    Ricardo Julian Cabezas-Perez; Andres Felipe Vallejo-Pulido; Sofia Isabel Freyre-Bernal; Adriana Umana-Perez; Myriam Sanchez-Gomez

    2011-01-01

    .... El objetivo de este estudio fue establecer la interacción potencial entre los efectos funcionales de hCG y el IGF-II en la regulación de la proliferación, migración e invasión trofoblástica. Utilizando...

  12. IGF-II Y LA GONADOTROPINA CORIONICA REGULAN LA PROLIFERACION, MIGRACION E INVASION DE CELULAS DE TROFOBLASTO HUMANO.

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    Umana-Perez Adriana

    2011-04-01

    Full Text Available Son conocidas las propiedades del factor de crecimiento similar a la insulina IGF-II y de la hormona Gonadotropina Coriónica (hCG en la implantación y migración trofoblástica, sin embargo los mecanismos a través de los cuales ejercen sus efectos no han sido identificados. El objetivo de este estudio fue establecer la interacción potencial entre los efectos funcionales de hCG y el IGF-II en la regulación de la proliferación, migración e invasión trofoblástica. Utilizando la línea celular HTR-8/SVneo de trofoblasto extravelloso se pudo demostrar que tanto IGF-II como hCG estimulan la proliferación y migración celular sin observarse efectos aditivos en sus acciones, lo cual es indicativo independencia de sus mecanismos. En contraste, la capacidad invasiva del trofoblasto fue regulada por IGF-II y hCG, dando como resultado efectos aditivos o un potencial sinergismo entre las dos hormonas. En conclusión, nuestros resultados muestran la existencia de interacciones entre las acciones biológicas de IGF-II y hCG en la regulación de la capacidad invasiva de células trofoblásticas y contribuyen al entendimiento de la biología del trofoblasto y de su malignización.

  13. Intra-group diffuse light in compact groups of galaxies. HCG 79, HCG 88 and HCG 95

    CERN Document Server

    Rocha, C D; Rocha, Cristiano Da; Oliveira, Claudia Mendes de

    2005-01-01

    Deep $B$ and $R$ images of three Hickson Compact Groups, HCG 79, HCG 88 and HCG 95, were analyzed using a new wavelet technic to measure possible intra-group diffuse light present in these systems. The method used, OV\\_WAV, is a wavelet technic particularly suitable to detect low-surface brightness extended structures, down to a $S/N = 0.1$ per pixel, which corresponds to a 5-$\\sigma$-detection level in wavelet space. The three groups studied are in different evolutionary stages, as can be judged by their very different fractions of the total light contained in their intra-group halos: $46\\pm11$\\% for HCG 79 and $11\\pm26$\\% for HCG 95, in the $B$ band, and HCG 88 had no component detected down to a limiting surface brightness of $29.1~B~mag~arcsec^{-2}$. For HCG 95 the intra-group light is red, similar to the mean colors of the group galaxies themselves, suggesting that it is formed by an old population with no significant on-going star formation. For HCG 79, however, the intra-group material has significantl...

  14. 1550-nm wavelength-tunable HCG VCSELs

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    Chase, Christopher; Rao, Yi; Huang, Michael; Chang-Hasnain, Connie

    2014-02-01

    We demonstrate wavelength-tunable VCSELs using high contrast gratings (HCGs) as the top output mirror on VCSELs, operating at 1550 nm. Tunable HCG VCSELs with a ~25 nm mechanical tuning range as well as VCSELs with 2 mW output power were realized. Error-free operation of an optical link using directly-modulated tunable HCG VCSELs transmitting at 1.25 Gbps over 18 channels spaced by 100 GHz and transmitted over 20 km of single mode fiber is demonstrated, showing the suitability of the HCG tunable VCSEL as a low cost source for WDM communications systems.

  15. Desenvolvimento folicular no pós-parto de vacas da raça Gir tratadas com acetato de buserelina (GnRH ou gonadotrofina coriônica humana (hCG Follicular development in Gir breed cows (Bos indicus treated with buserelin acetate or human chorionic gonadotrophin during the postpartum period

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    Álan Maia Borges

    2004-12-01

    Full Text Available Foram utilizadas 22 vacas da raça Gir (Bos indicus em anestro pós-parto, amamentando e mantidas sob regime de pastejo. O padrão de crescimento folicular foi estudado em 15 animais, enquanto os outros sete foram utilizados somente no acompanhamento da resposta aos tratamentos hormonais. Ultra-sonografia em tempo real foi realizada diariamente, do quarto ao qüinquagésimo dia de lactação, por meio de aparelho equipado com probe de 5MHz. Nenhum animal apresentou estro, ovulação ou luteinização folicular durante o período de avaliação. Verificaram-se quatro a oito ondas foliculares surgindo em intervalos de seis a sete dias, cujo diâmetro máximo dos folículos dominantes e subordinados foi de 8,9±0,6 e 6,3±0,7mm, respectivamente. Aos 56 dias pós-parto, as 22 vacas foram divididas em dois grupos: 11 tratadas com 4,2 mig de acetato de buserelina e 11 com 3.000UI de hCG. A ovulação, regressão e luteinização folicular foram verificadas em animais dos dois tratamentos e uma nova onda folicular surgiu dentro de dois a três dias após a terapia hormonal. Corpos lúteos de menor tamanho e concentrações de progesterona abaixo de 1ng/mL indicaram baixa atividade luteal.This experiment was carried out with 22 anestrus Gir cows (Bos indicus, with the postpartum follicular growth studied in 15 of these suckling and kept on pasture, while the seven others were used only for hormonal treatments. Daily real time ultrasonography was done from 4th to the 50th day, using B-mode ultrasound scanner equipped with a linear array 5.0MHz probe. No animal showed estrus, ovulation or follicular luteinization during de experimental period. Four to eight follicular waves emerged each six or seven days and maximum diameter of dominant and subordinate follicles were 8.9±0.6mm and 6.3±0.7mm, respectively. On day 56 of postpartum all cows were separated in two groups: 11 cows were treated either with 4.2 mug of buserelin acetate and 11 with 3,000UI of hCG

  16. Musica Humana og musikterapi

    DEFF Research Database (Denmark)

    Schou, Karin

    2005-01-01

    I pressen har Musica Humanas projekter på flere danske sygehuse jævnligt været omtalt i de seneste to år, særligt i forbindelse med udgivelsen af serien MusiCure’s foreløbig fire Cd’er. Ordet ’musikterapi’ er blevet anvendt til beskrivelse af disse projekters metode. I artiklen redegøres for defi......I pressen har Musica Humanas projekter på flere danske sygehuse jævnligt været omtalt i de seneste to år, særligt i forbindelse med udgivelsen af serien MusiCure’s foreløbig fire Cd’er. Ordet ’musikterapi’ er blevet anvendt til beskrivelse af disse projekters metode. I artiklen redegøres...... for definitioner af relevante niveauer af musikterapi i denne sammenhæng; Musica Humanas formål; MusiCure’s tilblivelse; baggrunden for og relevansen af en musikterapeuts tilstedeværelse i Musica Humana, samt hvilken rolle musikterapeuten kan spille i denne sammenhæng. Medlemmer af Musica Humanas styregruppe...... bidrager med udsagn om deres opfattelse af relevansen af en musikterapeut som ressourceperson i Musica Humana....

  17. Musica Humana og musikterapi

    DEFF Research Database (Denmark)

    Schou, Karin

    2005-01-01

    I pressen har Musica Humanas projekter på flere danske sygehuse jævnligt været omtalt i de seneste to år, særligt i forbindelse med udgivelsen af serien MusiCure’s foreløbig fire Cd’er. Ordet ’musikterapi’ er blevet anvendt til beskrivelse af disse projekters metode. I artiklen redegøres for defi......I pressen har Musica Humanas projekter på flere danske sygehuse jævnligt været omtalt i de seneste to år, særligt i forbindelse med udgivelsen af serien MusiCure’s foreløbig fire Cd’er. Ordet ’musikterapi’ er blevet anvendt til beskrivelse af disse projekters metode. I artiklen redegøres...... for definitioner af relevante niveauer af musikterapi i denne sammenhæng; Musica Humanas formål; MusiCure’s tilblivelse; baggrunden for og relevansen af en musikterapeuts tilstedeværelse i Musica Humana, samt hvilken rolle musikterapeuten kan spille i denne sammenhæng. Medlemmer af Musica Humanas styregruppe...... bidrager med udsagn om deres opfattelse af relevansen af en musikterapeut som ressourceperson i Musica Humana....

  18. hCG - related molecules and their measurement.

    Science.gov (United States)

    Szczerba, Anna; Białas, Piotr; Pięta, Paweł Piotr; Jankowska, Anna

    2016-01-01

    Measurements of human chorionic gonadotropin (hCG) synthesized by trophoblast cells is a powerful tool of pregnancy monitoring. It was showed that similarly to pregnancy also trophoblastic and nontrophoblastic malignancies produce variety of hCG molecules. In urine and serum of both pregnant women and tumors patients a fifteen various forms of hCG, such as: regular hCG, hyperglycosylated hCG and predominant hyperglycosylated hCG free β, were identified. These forms might be useful in order to recognize between physiological and pathological pregnancies as well as cancers. Even the presence of these different hormone variants is well documented the commercially available biochemical tests detecting hCG failed to identified and distinguish among these forms. Especially hard is to identify glycan chains linked to heterodimer. Thus, a detailed analysis of hCG-related molecules produced during physiological and pathological condition, together with a new tests development are needed.

  19. H I in group interactions: HCG 44

    Science.gov (United States)

    Hess, Kelley M.; Cluver, M. E.; Yahya, Sahba; Leisman, Lukas; Serra, Paolo; Lucero, Danielle M.; Passmoor, Sean S.; Carignan, Claude

    2017-01-01

    Extending deep observations of the neutral atomic hydrogen (H I) to the environment around galaxy groups can reveal a complex history of group interactions which is invisible to studies that focus on the stellar component. Hickson Compact Group 44 (HCG 44) is a nearby example, and we have combined H I data from the Karoo Array Telescope, Westerbork Synthesis Radio Telescope, and Arecibo Legacy Fast ALFA survey, in order to achieve high column density sensitivity (N _{H {I}}<2× 10^{18} cm-2) to the neutral gas over a large field of view beyond the compact group itself. We find that the giant H I tail north of HCG 44 contains 1.1 × 109 M⊙ of gas and extends 450 kpc from the compact group: twice as much mass and 33 per cent further than previously detected. However, the additional gas is still unable to account for the known H I deficiency of HCG 44. The tail likely formed through a strong tidal interaction and H I clouds in the tail have survived for 1 Gyr or more after being stripped. This has important implications for understanding the survival of neutral clouds in the intragroup and circumgroup medium, and we discuss their survival in the context of simulations of cold gas in hot haloes. HCG 44 is one of a growing number of galaxy groups found to have more extended H I in the intragroup and circumgroup medium than previously measured. Our results provide constraints for simulations on the properties of galaxy group haloes, and reveal a glimpse of what will be seen by future powerful H I telescopes and surveys.

  20. H I in Group Interactions: HCG 44

    Science.gov (United States)

    Hess, Kelley M.; Cluver, M. E.; Yahya, Sahba; Leisman, Lukas; Serra, Paolo; Lucero, Danielle M.; Passmoor, Sean S.; Carignan, Claude

    2016-09-01

    Extending deep observations of the neutral atomic hydrogen (H I) to the environment around galaxy groups can reveal a complex history of group interactions which is invisible to studies that focus on the stellar component. Hickson Compact Group 44 (HCG 44) is a nearby example and we have combined H I data from the Karoo Array Telescope, Westerbork Synthesis Radio Telescope, and Arecibo Legacy Fast ALFA survey, in order to achieve high column density sensitivity (NHI gas over a large field-of-view beyond the compact group itself. We find the giant H I tail north of HCG 44 contains 1.1 × 109 M⊙ of gas and extends 450 kpc from the compact group: twice as much mass and 33% further than previously detected. However, the additional gas is still unable to account for the known H I deficiency of HCG 44. The tail likely formed through a strong tidal interaction and H I clouds in the tail have survived for 1 Gyr or more after being stripped. This has important implications for understanding the survival of neutral clouds in the intragroup and circumgroup medium, and we discuss their survival in the context of simulations of cold gas in hot halos. HCG 44 is one of a growing number of galaxy groups found to have more extended H I in the intragroup and circumgroup medium than previously measured. Our results provide constraints for simulations on the properties of galaxy group halos, and reveal a glimpse of what will be seen by future powerful H I telescopes and surveys.

  1. HI in Group Interactions: HCG 44

    CERN Document Server

    Hess, Kelley M; Yahya, Sahba; Leisman, Lukas; Serra, Paolo; Lucero, Danielle M; Passmoor, Sean S; Carignan, Claude

    2016-01-01

    Extending deep observations of the neutral atomic hydrogen (HI) to the environment around galaxy groups can reveal a complex history of group interactions which is invisible to studies that focus on the stellar component. Hickson Compact Group 44 (HCG 44) is a nearby example and we have combined HI data from the Karoo Array Telescope, Westerbork Synthesis Radio Telescope, and Arecibo Legacy Fast ALFA survey, in order to achieve high column density sensitivity (N_HI < 2x10^18 cm^-2) to the neutral gas over a large field-of-view beyond the compact group itself. We find the giant HI tail north of HCG 44 contains 1.1x10^9 M_Sun of gas and extends 450 kpc from the compact group: twice as much mass and 33% further than previously detected. However, the additional gas is still unable to account for the known HI deficiency of HCG 44. The tail likely formed through a strong tidal interaction and HI clouds in the tail have survived for 1 Gyr or more after being stripped. This has important implications for understan...

  2. Vida humana y persona

    Directory of Open Access Journals (Sweden)

    Antonio Marlasca López

    2002-09-01

    Full Text Available En este ensayo, más que un juego lingüístico de términos y expresiones, se tratara de enfatizar los términos vida humana y persona humana, como estos de la simple sinonimia en la conversación habitual, han sido trastocados en sofisticado instrumento jurídico, al concluir en Costa Rica la Sala Constitucional, por quien sabe que ciencia infusa, que el embrión recién fecundado ya es persona. Por tanto se enfatiza con fuerza el contrasentido de aseverar que el principio y el producto son lo mismo, entendiendo que la semilla es diferente al fruto, citando a Savater, cuando dijo que el que come un huevo no ha comido pollo. El embrión recién fecundado o pre-embrión, es principio, semilla, potencia, quizás un día sea persona, de ahí la conclusión de que no toda vida humana es persona humana.In this essay, more than a linguistic game of terms and expressions, we treat the meanings of human life and the human person, and how this simooms in the habitual language, have been to changed into a sophisticated judicial tool, by the conclusion of the Costa Rican Constitutional Court, who using a mysterious science, has said that once the ovule has been fecund, it is a human being. For that reason we emphasize the contra sense to sever that the beginning is the same than the product, understanding that the seed is different than the fruit, referring to Savater, when he said, when you eat an egg you are not eat chicken. The embryo recently fecund or pre-embryo is beginning, seed, potency, maybe one day it will be a human person, from there the conclusion that not all human life is a human person.

  3. hCG, the wonder of today's science

    Science.gov (United States)

    2012-01-01

    Background hCG is a wonder. Firstly, because hCG is such an extreme molecule. hCG is the most acidic glycoprotein containing the highest proportion of sugars. Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these molecules in detail. Content These 5 molecules, hCG, sulfated hCG, hyperglycosylated hCG, hCG free beta and hyperglycosylated free beta are produced by placental syncytiotrophoblast cells and pituitary gonadotrope cells (group 1), and by placental cytotrophoblast cells and human malignancies (group 2). Group 1 molecules are both hormones that act on the hCG/LH receptor. These molecules are central to human menstrual cycle and human pregnancy. Group 2 molecules are autocrines, that act by antagonizing a TGF beta receptor. These molecules are critical to all advanced malignancies. Conclusions The hCG groups are molecules critical to both the molecules of pregnancy or human life, and to the advancement of cancer, or human death. PMID:22455390

  4. PERSONA HUMANA Y PERSONALISMO

    OpenAIRE

    Elio Sgreccia

    2013-01-01

    En la primera parte del artículo se analiza la evolución histórico-filosófica del concepto de persona humana, desde la antigüedad hasta el pensamiento contemporáneo, enunciando las ideas más relevantes al respecto. En la segunda parte se realiza un análisis crítico de las posiciones reduccionistas o empiristas, en particular de las de Engelhardt y el utilitarismo, analizando algunas de sus consecuencias prácticas en bioética. El autor concluye enunciando lo que serían los principios fundament...

  5. The biological function of hyperglycosylated hCG

    Institute of Scientific and Technical Information of China (English)

    Laurence A Cole; Stephen A Butler

    2012-01-01

    Objective:Hyperglycosylated human chorionic gonadotropin(hCG) is a variant of hCG made by cytotrophoblast cell.Here we examine the role of hyperglycosylated hCG in placenta growth and invasion.Methods:JEG-3 choriocarcinoma cells and term cytotrophoblast monolayer culture were prepared.The effect of supplemental hyperglycosylated hCG and hCG was investigated. Growth of these cells was examined by increase incell number.Invasion was investigated using Matrigel basement membrane cells.The proportion of cell invadingMatrigel was determined. Results:Term cytotrophoblast cell andJEG-3 choriocarcinoma cells grew to5427±834 cells (109%) and7114±553 cells(142%).With the supplementation of hyperglycosylated hCG, they grew significantly wider to7633±177 cells(142%) and10315±1477 cells(206%).With the supplementation of hCG they diminished to4227±769 cells(78%) and5620±657 cells(79%).Term cytotrophoblast cell andJEG-3 choriocarcinoma cells penetratedMatigel membranes to(40.0±10.0)% and(46.0±9.8)%.Hyperglycosylated hCG significantly enhanced penetration to(76.0±13.0)% and(84.0±6.6)%. hCG diminished penetration to(32.0±9.1)% and(32.0±4.5)%.Conclusions:Hyperglycosylated hCG enhances both cytotrophoblast growth and cytotrophoblast cell invasion. hCG minimally suppresses growth and invasion.

  6. La agresividad humana

    Directory of Open Access Journals (Sweden)

    Olimpia López Avendaño

    2004-01-01

    Full Text Available En este artículo se comparan los planteamientos de Sigmund Freud, Herbert Marcusse y Erich Fromm en torno a la agresividad humana. Analizar esta temática en el contexto actual es relevante dado el incremento de acciones que conllevan gran dosis de violencia tanto en el plano físico, como en el psicológico y espiritual, así como la urgencia de plantear soluciones. La posición de los tres autores permite visualizar la pertinencia de explicaciones que tienden a asumirse en la vida cotidiana en torno a este fenómeno y, sobre todo, construir nuevas perspectivas que las relean, trasciendan y enriquezcan.

  7. PERSONA HUMANA Y PERSONALISMO

    Directory of Open Access Journals (Sweden)

    Elio Sgreccia

    2013-01-01

    Full Text Available En la primera parte del artículo se analiza la evolución histórico-filosófica del concepto de persona humana, desde la antigüedad hasta el pensamiento contemporáneo, enunciando las ideas más relevantes al respecto. En la segunda parte se realiza un análisis crítico de las posiciones reduccionistas o empiristas, en particular de las de Engelhardt y el utilitarismo, analizando algunas de sus consecuencias prácticas en bioética. El autor concluye enunciando lo que serían los principios fundamentales de la bioética personalista, su fundamentación ontológica, así como el posible desarrollo contemporáneo de la intuición inicial, enunciada por vez primera por Sgreccia en los ochenta.

  8. Establishing reference intervals for hCG in postmenopausal women.

    Science.gov (United States)

    Patel, Khushbu K; Qavi, Abraham J; Hock, Karl G; Gronowski, Ann M

    2017-03-01

    Plasma concentrations of human chorionic gonadotropin (hCG) have been shown to increase with age due to pituitary secretion. We previously recommended that an hCG cutoff of 14.0IU/L be used for women ≥55years of age. However, it remains unknown whether concentrations >14.0IU/L can be expected in women with advanced age. Our objectives were to establish plasma hCG reference intervals and correlate follicle stimulating hormone (FSH) and hCG concentrations in postmenopausal females ≥55years. Residual plasma samples from 798 women ≥55years were utilized with 303, 269, and 226 samples belonging to the age groups 55-69, 70-84, and ≥85years, respectively. FSH and hCG were measured using the Abbott ARCHITECT. All positive hCG samples (hCG ≥5IU/L) were analyzed for potential heterophile antibody interference and 3 were excluded. Electronic medical records were reviewed and patients with malignancy were excluded. 8% (56/666) of women age≥55years had plasma hCG ≥5IU/L. There were 19, 16, and 21 patients with hCG ≥5IU/L in the age groups 55-69, 70-84, and ≥85years, respectively. The highest hCG concentrations observed in each age group were: 55-69years maximum=11.7IU/L and 97.5th percentile=9.6IU/L; 70-84years maximum=18.09IU/L, 97.5th percentile=6.2IU/L; ≥85years maximum=11.1IU/L and 97.5th percentile=10.0IU/L, and the overall 97.5th percentile=8.5IU/L for all women ≥55years of age. Neither hCG nor FSH concentrations continued to increase with age in women ≥55years. The prevalence of positive hCG in women ≥55years is 8%. This study confirms our previously recommended cutoff of 14IU/L for women ≥55years of age. In women ≥55years of age, FSH concentrations do not predict hCG concentrations. Copyright © 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  9. Proportion hyperglycosylated hCG: a new test for discriminating gestational trophoblastic diseases.

    Science.gov (United States)

    Cole, Laurence A

    2014-11-01

    Hyperglycosylated human chorionic gonadotropin (hCG) is a variant of hCG with large oligosaccharide side chains. Although hCG is produced by syncytiotrophoblast cells, hyperglycosylated hCG marks cytotrophoblast cell. Hyperglycosylated hCG signals placental implantation. Total hCG in serum and urine is measured by the Siemens Immulite hCG pregnancy test; the result is in milli-international unit per milliliter. Hyperglycosylated hCG is determined by the B152 microtiter plate assay; the result is in nanogram per milliliter. Hyperglycosylated hCG results can be converted to milli-international unit per milliliter equivalents by multiplying by 11. The test measures proportion hyperglycosylated hCG, hyperglycosylated hCG / total hCG. Proportion hyperglycosylated hCG marks cases intent on developing persistent hydatidiform mole (68% detection at 17% false detection). Proportion hyperglycosylated hCG also marks persistent hydatidiform mole (100% detection at 5.1% false detection). Proportion hyperglycosylated hCG distinguishes choriocarcinoma and gestational trophoblastic neoplasm cases, absolutely discriminating aggressive cases and minimally aggressive cases. Proportion hyperglycosylated hCG identifies quiescent gestational trophoblastic disease cases. It recognizes quiescent cases that become persistent disease (100% detection at 0% false positive). Proportion hyperglycosylated hCG is an invaluable test for discriminating gestational trophoblastic diseases.

  10. HCG variants, the growth factors which drive human malignancies

    Science.gov (United States)

    Cole, Laurence A

    2012-01-01

    The term human chorionic gonadotropin (hCG) refers to a group of 5 molecules, each sharing the common amino acid sequence but each differing in meric structure and carbohydrate side chain structure. The 5 molecules are each produced by separate cells and each having separate biological functions. hCG and sulfated hCG are hormones produced by placental syncytiotrophoblast cells and pituitary gonadotrope cells. Hyperglycosylated hCG is an autocrine produced by placental cytotrophoblast cells. Hyperglycosylated hCG drives malignancy in placental cancers, and in testicular and ovarian germ cell malignancies. hCGβ and hyperglycosylated hCGβ are autocrines produce by most advanced malignancies. These molecules, particularly the malignancy promoters are presented in this review on hCG and cancer. hCGβ and hyperglycosylated hCGβ are critical to the growth and invasion, or malignancy of most advanced cancers. In many ways, while hCG may appear like a nothing, a hormone associated with pregnancy, it is not, and may be at the center of cancer research. PMID:22206043

  11. LA FORMA HUMANA

    Directory of Open Access Journals (Sweden)

    GERMÁN ENRIQUE BELTRÁN

    2015-03-01

    Full Text Available Como pedagogos constituimos una gran organización  de sinceros aspirantes al poder que proviene del conocimiento,  y el conocimiento es el único poder que necesitamos.  Nos circundan por todos lados las más poderosas fuerzas,  podemos pensar que la dinámica es un poder maravilloso,  una fuerza de gran potencia, cuando se le deja libre,  pero este poder no es nada en comparación con la potencia  del poder y fuerza contenidos en el electrón invisible o átomo  de materia, si pudiéramos liberarlo con tal facilidad como  lo hacemos con la fuerza de la dinámica.  La fuerza llamada de gravitación no es más potente que la  fuerza que cualquier motor eléctrico halla sido capaz de  producir. La fuerza y poder que existe dentro del cuerpo  humano, llamada también vitalidad humana o magnetismo  es mucho mas grande y dinámica de lo que nos imaginamos.  Tenemos también el poder, la fuerza potente que se  manifiesta a través de la mente humana.

  12. La agresividad humana

    Directory of Open Access Journals (Sweden)

    López Avendaño, Olimpia

    2004-12-01

    Full Text Available En este artículo se comparan los planteamientos de Sigmund Freud, Herbert Marcusse y Erich Fromm en torno a la agresividad humana. Analizar esta temática en el contexto actual es relevante dado el incremento de acciones que conllevan gran dosis de violencia tanto en el plano físico, como en el psicológico y espiritual, así como la urgencia de plantear soluciones. La posición de los tres autores permite visualizar la pertinencia de explicaciones que tienden a asumirse en la vida cotidiana en torno a este fenómeno y, sobre todo, construir nuevas perspectivas que las relean, trasciendan y enriquezcan. In this article the expositions regarding human aggressiveness by Sigmund Freud, Herbert Marcusse and Erich Fromm are compared. The relevance of this subject's analysis in the present context is due to the increase of actions that entail a great dose of violence in the physical, psychological and spiritual planes; and to the urgency of raising solutions. The three authors' position allows us to see how adequate are the explanations that tend to be assumed in everyday life; and above all allow us to build new perspectives that make a new interpretation of them, that extend and enrich them

  13. clonación humana

    Directory of Open Access Journals (Sweden)

    Aída María Ponce del Castillo

    2006-01-01

    Full Text Available El incesante desarrollo de la ingeniería genética en el ámbito mundial genera profundos cuestionamientos éticos, legales y sociales por las consecuencias que estas investigaciones pueden tener tanto en los individuos en lo particular, como en el futuro de la especie humana en general. El experto en bioética Leon R. Kass ha realizado un profundo estudio de los alcances de esas experimentaciones, y particularmente con respecto a la clonación humana, advirtiendo situaciones complejas que no se deben pasar por alto. A lo largo de este trabajo examino el pensamiento de Leon Kass respecto a la clonación de seres humanos que, según nos refiere, despersonalizaría la reproducción humana, tendría influencia significativa sobre las generaciones futuras y, finalmente provocaría la degradación del hombre.

  14. HCG concentration and receptor gene expression in placental tissue from trisomy 18 and 21.

    Science.gov (United States)

    Jauniaux, E; Bao, S; Eblen, A; Li, X; Lei, Z M; Meuris, S; Rao, C V

    2000-01-01

    Trisomy 21 is associated with high maternal serum concentrations of intact human chorionic gonadotrophin alpha(HCG) and free beta-HCG whereas these concentrations are markedly decreased in trisomy 18. In this study, we investigated the effect of trisomy 21 and 18 on endogenous HCG concentrations and luteinizing hormone (LH)/HCG receptor expression in placental villous tissue in eight trisomy 21, six trisomy 18 and 42 chromosomally normal samples, collected at 12-16 weeks gestation. The tissue concentrations of intact HCG, free alpha-HCG and free beta-HCG subunits were measured using solid-phase two-site immunoradiometric assay. LH/HCG receptor expression was evaluated with immunohistochemistry and in-situ hybridization. Villous tissue in trisomy 21 contained higher beta-HCG concentrations than the controls (P trisomy 18 cases, the beta-HCG concentration was lower than in the control group (P trisomy 21 and 18, compared with controls with the strongest signal in cases of trisomy 18 (P trisomy 21 the high tissue HCG concentration and expression of LH/HCG receptor in the trophoblast may reflect the relative immaturity of the trophoblastic tissue whereas in trisomy 18, the very low concentration of endogenous HCG, associated with an over-expression of LH/HCG receptor in the trophoblast, is probably secondary to the poor differentiation of the cytotrophoblast.

  15. [Precocious puberty due to HCG secreting pinealoma (author's transl)].

    Science.gov (United States)

    Rosenberg, D

    The present report concerns a six years nine months old boy in whom a HCG secreting pineal tumor (pinealocytoma type I) was responsible for precocious puberty. Features : polydipsia, deepened voice, pubic hair, penile enlargement without corresponding testicular growth. Serum basal concentrations of LH (150 mU/ml), testosterone (85.80 nanomole/l), HCG (115 ng/ml) and its beta subunit (15 ng/ml) were markedly elevated, FSH was low (3.9 mU/ml) ] dissociated hypopituitarism was also present. A surgical removal of the tumor was performed (RIA of the neoplastic tissue revealed high HCG and beta HCG activity) and after the operation the child had radiation therapy. Recovery for the foregoing procedure was rapid, but after some months, in spite chemotherapy his condition deteriorated progressively. The apparent limitation of pinealoma and precocious puberty to the male sex is discussed and supposed to be partly the result of the ectopic gonadotropin secretion. These tumors are compared to other HCG secreting carcinomas located elsewhere in the body and causing sexual precocity in boys only.

  16. Star Formation in Hi Tails: HCG 92, HCG 100 and 6 Interacting Systems

    Science.gov (United States)

    deMello, D. F.; Urrutia-Viscarra, F.; MendesdeOliveira, C.; Torres-Flores, S.; Carrasco, E. R.; Cypriano, E.

    2012-01-01

    We present new Gemini spectra of 14 new objects found within the HI tails of Hickson Compact Groups 92 and 100. Nine of them are GALEX Far-UV (FUV) and Near-UV (NUV) sources. The spectra confirm that these objects are members of the compact groups and have metallicities close to solar, with an average value of 12+log(O/H)approx.8.5. They have average FUV luminosities 7 x 10(exp 40) erg/s, very young ages (HI tails, NGC 2623, NGC 3079, NGC 3359, NGC 3627, NGC 3718, NGC 4656. We found 35 UV sources with ages < 100 Myr, however most of them are on average less luminous/massive than the UV sources found around HCG 92 and 100. We speculate that this might be an environmental effect and that compact groups of galaxies are more favorable to TDG formation than other interacting systems.

  17. 21 CFR 862.1155 - Human chorionic gonadotropin (HCG) test system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Human chorionic gonadotropin (HCG) test system... Test Systems § 862.1155 Human chorionic gonadotropin (HCG) test system. (a) Human chorionic gonadotropin (HCG) test system intended for the early detection of pregnancy—(1) Identification. A human...

  18. Gestión humana

    Directory of Open Access Journals (Sweden)

    Rafael Ignacio Pérez

    2013-07-01

    Full Text Available Este artículo resume el trabajo que esta realizando el grupo PYMES de investigación de la EAN en Bogotá D.C., sobre el componente organizacional de gestión humana y cultura organizacional y como se traduce en competencias de nivel cuatro o de categoría mundial para PYMES que quieran crear escenarios de innovación en valor.

  19. A 3D analysis of the metal distribution in the compact group of galaxies HCG 31

    Science.gov (United States)

    Torres-Flores, Sergio; Mendes de Oliveira, Claudia; Alfaro-Cuello, Mayte; Rodrigo Carrasco, Eleazar; de Mello, Duilia; Amram, Philippe

    2015-02-01

    We present new Gemini/GMOS integral field unit observations of the central region of the merging compact group of galaxies HCG 31. Using this data set, we derive the oxygen abundances for the merging galaxies HCG 31A and HCG 31C. We found a smooth metallicity gradient between the nuclei of these galaxies, suggesting a mixing of metals between these objects. These results are confirmed by high-resolution Fabry-Perot data, from which we infer that gas is flowing between HCG 31A and HCG 31C.

  20. [Mechanism of regulation of synthesis and secretion of human chorionic gonadotropin (hCG) during pregnancy].

    Science.gov (United States)

    Barrera, David; Chirinos, Mayel; García-Becerra, Rocío

    2008-01-01

    Human chorionic gonadotropin (hCG) is an essential hormone for development and sustaining of gestation. Adequate hCG production is fundamental for pregnancy success since abnormal hCG serum concentrations have been correlated with pregnancy anomalies such as recurrent abortions and preeclampsia. Regulation of hCG production involves diverse molecules associated with different signaling pathways, which have complicated the establishment of the mechanisms involved in its production. The present study provides a critical review of the most relevant findings related to hCG production and functions during pregnancy, in order to help to understand some related pathologies and to treat them more adequately.

  1. Serum hCG Levels following the Ovulatory Injection: Associations with Patient Weight and Implantation Time

    Science.gov (United States)

    Noorhasan, Dorette J.; McGovern, Peter G.; Cho, Michael; Seungdamrong, Aimee; Ahmad, Khaliq; McCulloh, David H.

    2015-01-01

    Objective. To test if serum hCG levels the morning after the ovulatory hCG injection correlate with (1) retrieval efficiency, (2) oocyte maturity, (3) embryo quality, (4) pregnancy, and/or (5) time to implantation in patients undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). Design. Retrospective cohort analysis. Setting. University-based IVF clinic. Patient(s). All IVF/ICSI cycles from April 2005 to February 2008 whose hCG administration was confirmed (n = 472 patients). Intervention(s). Serum hCG was measured the morning following the ovulatory injection, on the 16th day following retrieval, and repeated on day 18 for those with positive results. Main Outcome Measure(s). Number of follicles on the day of hCG injection, number of oocytes retrieved, maturity of oocytes, embryo quality, pregnancy outcome, and time to implantation. Result(s). hCG levels did not correlate with retrieval efficiency, oocyte maturity, embryo quality, or pregnancy. Postinjection hCG levels were inversely associated with patient weight and time to implantation. Conclusion(s). No correlation was found between hCG level and any parameter of embryo quality. Patient weight affected hCG levels following hCG injection and during the early period of pregnancy following implantation. No association between postinjection hCG level and time of implantation (adjusted for patient weight) was apparent. PMID:26587025

  2. Absence of TGF-β Receptor Activation by Highly Purified hCG Preparations.

    Science.gov (United States)

    Koistinen, Hannu; Hautala, Laura; Koli, Katri; Stenman, Ulf-Håkan

    2015-12-01

    Recently, several LH/human chorionic gonadotropin (hCG) receptor-independent activities for hCG have been described, including activation of the TGF-β receptor (TGFβR) by hyperglycosylated hCG and stimulation of trophoblast invasion. Because the hCG concentrations used in these studies have been rather high, reflecting physiological hCG levels in pregnancy, even a minor contamination with growth factors, which act at very low concentrations, may be significant. Several commercial hCG preparations have been found to contain significant amounts of epidermal growth factor (EGF), which we also confirmed here. Furthermore, we found that some hCG preparations also contain significant amounts of TGF-β1. These hCG preparations were able to activate ERK1/2 in JEG-3 choriocarcinoma cells or TGFβR in mink lung epithelial cells transfected with a reporter gene for TGFβR activation. No such activation was found with highly purified hCG or its free β-subunit (hCGβ), irrespective of whether they were hyperglycosylated or not. Taken together, our results suggest that the growth factor contaminations in the hCG preparations can cause activation of TGFβR and, at least in JEG-3 cells, MAPK signaling. This highlights the importance to carefully control for potential contaminations and that highly purified hCG preparations have to be used for biological studies.

  3. [Influence of hCG glycosylation on its functions in female reproduction].

    Science.gov (United States)

    Oborná, I; Fingerová, H

    2017-01-01

    To review contemporary knowledge of the hCG molecule, its isoforms and the importance of glycosylation. Biologic variants and glycoforms of hCG have different biological activities and functions related to the control of menstrual cycle, conception, gestation as well as gynaecologic and non-gynaecologic malignancies. A review. Department of Obstetrics and Gynaecology, University Hospital Olomouc. To present own experience and an overview of recent literature in molecular biology, clinical biochemistry and clinical practice. Recent knowledge of the role of hCG glycosylation in physiologic and pathologic events in female organism will provide a better understanding of regulation of processes like ovulation (co-operation of pituitary hCG with LH), implantation and hemochorial placentation (invasivity of hyperglycosylated hCG). Some biologic variants and isoforms of hCG are important for the prediction of certain pathologies of pregnancy, prenatal screening of inborn errors (free beta hCG) as well as in the treatment of infertility.

  4. Fraccionando la microbiota gastrointestinal humana

    OpenAIRE

    Peris Bondia, Francisco

    2012-01-01

    La microbiota gastrointestinal humana es una de las comunidades microbianas más diversa y compleja que se puede encontrar en la naturaleza. Las nuevas tecnologías de secuenciación permiten obtener una amplia visión de la diversidad microbiana, lo que ha revelado una gran cantidad de bacterias no cultivables. A pesar del potencial de estas tecnologías de alto rendimiento la metagenómica no muestra la imagen completa. La citometría de flujo es una metodología que permite describir y/o separa...

  5. Desarrollo local a escala humana

    OpenAIRE

    Romero Marques, Heitor

    2012-01-01

    El presente artículo tiene como objetivo aclarar algunos conceptos sobre desarrollo local a escala humana, a través una revisión bibliográfica. Para este propósito el trabajo está conformado de dos partes: conceptos sobre desarrollo local, y desarrollo local y su semántica. En la primera parte se aborda el desarrollo local en sentido etimológico, semántico, de espacio, de territorio, de comunidad, lugar y paisaje. En la segunda parte se presentan los supuestos y datos históricos, variaciones ...

  6. Micro-dose hCG as luteal phase support without exogenous progesterone administration: mathematical modelling of the hCG concentration in circulation and initial clinical experience.

    Science.gov (United States)

    Andersen, C Yding; Fischer, R; Giorgione, V; Kelsey, Thomas W

    2016-10-01

    For the last two decades, exogenous progesterone administration has been used as luteal phase support (LPS) in connection with controlled ovarian stimulation combined with use of the human chorionic gonadotropin (hCG) trigger for the final maturation of follicles. The introduction of the GnRHa trigger to induce ovulation showed that exogenous progesterone administration without hCG supplementation was insufficient to obtain satisfactory pregnancy rates. This has prompted development of alternative strategies for LPS. Augmenting the local endogenous production of progesterone by the multiple corpora lutea has been one focus with emphasis on one hand to avoid development of ovarian hyper-stimulation syndrome and, on the other hand, to provide adequate levels of progesterone to sustain implantation. The present study evaluates the use of micro-dose hCG for LPS support and examines the potential advances and disadvantages. Based on the pharmacokinetic characteristics of hCG, the mathematical modelling of the concentration profiles of hCG during the luteal phase has been evaluated in connection with several different approaches for hCG administration as LPS. It is suggested that the currently employed LPS provided in connection with the GnRHa trigger (i.e. 1.500 IU) is too strong, and that daily micro-dose hCG administration is likely to provide an optimised LPS with the current available drugs. Initial clinical results with the micro-dose hCG approach are presented.

  7. Analytical sensitivity of four commonly used hCG point of care devices.

    Science.gov (United States)

    Kamer, Sandy M; Foley, Kevin F; Schmidt, Robert L; Greene, Dina N

    2015-04-01

    Point of care (POC) hCG assays are often used to rule-out pregnancy and therefore diagnostic sensitivity, especially at low concentrations of hCG, is important. There are very few studies in the literature that seek to verify the claimed analytical sensitivity of hCG POC devices. The analytical sensitivity of four commonly used hCG POC devices (Alere hCG Combo Cassette, ICON 20 hCG, OSOM hCG Combo Test, and Sure-Vue Serum/Urine hCG-STAT) was challenged using urine samples (n=50) selected based on quantitative hCG concentrations. The majority of these specimens (n=40) had an hCG concentration between 20 and 200 U/L. Each specimen/device combination was reviewed by three individuals. Statistical calculations were performed using Stata 12. The analytical sensitivity of the OSOM was significantly lower inferior than that of the other POC devices. There was no significant difference in the sensitivity of the Alere, ICON 20 and Sure-Vue devices. There was no significant difference in the individual interpretation of the hCG POC results. All hCG POC devices evaluated in this study were susceptible to false negative results at low concentrations of urine hCG. Laboratorians and clinicians should be aware that there are limitations when using urine hCG POC devices to rule out early pregnancy. Copyright © 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  8. Effect of additional human chorionic gonadotrophin (hCG) on follicular growth and ovulation in gonadotrophin-treated gilts.

    Science.gov (United States)

    Manjarín, Rodrigo; Cassar, Glen; Friendship, Robert M; Garcia, José C; Dominguez, J Carlos; Kirkwood, Roy N

    2015-07-01

    The objective of this study was to determine the effect of additional human chorionic gonadotrophin (hCG) on the ovarian response of gilts previously treated with 200 IU hCG combined with 400 IU equine chorionic gonadotrophin (eCG) (eCG/hCG). Seventy-one prepuberal gilts (105 ± 7.5 kg) were assigned to groups: i) eCG/hCG (hCG-0; n = 25); ii) eCG/hCG followed by 100 IU of hCG at 24 h (hCG-100; n = 24); iii) eCG/hCG followed by 200 IU hCG at 24 h (hCG-200; n = 10); and iv) controls (CON; n = 12). Ovulation response was assessed by ovarian dissection or real-time ultrasonography. Additional hCG did not significantly improve numbers of gilts ovulating. Numbers of corpora lutea increased with hCG, and was higher in hCG-200 (P hCG-0, the frequency of cysts in gilts was higher in hCG-100 (P hCG-200 (P hCG. We conclude that supplemental hCG will increase the number of corpora lutea but will be associated with follicular cyst development in a dose dependent manner.

  9. Status of a Unique Vaccine against hCG for Contraception and Advanced Stage Cancers expressing ectopically hCG

    Directory of Open Access Journals (Sweden)

    Talwar GP

    2015-01-01

    Full Text Available Dear Egon!br God bless you on your 95th Birthday! May you complete 100 years.br Being submitted in your honor is a brief article on my continuing work to make available a unique vaccine preventing pregnancy in women without blocking ovulation, her normal production of sex steroid hormones and retaining her regular menstrual cycles and bleeding profiles.br The vaccine is directed at the Human chorionic gonadotropin (hCG, which emerges following fertilization of the egg [1]. Healthy, non-pregnant women do not make it, the basis on which its detection in serum or urine serves as a reliable test for diagnosis of pregnancy. It plays a critical role in implantation of the embryo & thereby to the onset of pregnancy. The purpose of the vaccine is to generate bioeffective antibodies neutralizing hCG & thereby prevent the onset of pregnancy.br As you can imagine, the making of a workable vaccine, competent to make antibodies against a tolerant molecule to the woman’s immune system (she literally bathes in hCG during pregnancy was not simple. What was also demanded was high immunogenicity of the vaccine to make fairly high titres of antibodies to counteract the large amount of hCG made in early pregnancy. At each stage, it required testing in humans and before that could be done, appropriate toxicology studies & approval of Regulatory and Ethics Committees was needed each taking its time. Eventually the vaccine has to be amenable to industrial production to reach the public, hence a recombinant vaccine had to be developed. Given below is a brief write-up on the evolution of the vaccine against the human chorionic gonadotropin.br Yours, Pran

  10. Reference ranges and determinants of total hCG levels during pregnancy: the Generation R Study.

    Science.gov (United States)

    Korevaar, Tim I M; Steegers, Eric A P; de Rijke, Yolanda B; Schalekamp-Timmermans, Sarah; Visser, W Edward; Hofman, Albert; Jaddoe, Vincent W V; Tiemeier, Henning; Visser, Theo J; Medici, Marco; Peeters, Robin P

    2015-09-01

    Human chorionic gonadotropin (hCG) is a pregnancy hormone secreted by the placental synctiotrophoblast cell layer that has been linked to fetal growth and various placental, uterine and fetal functions. In order to investigate the effects of hCG on clinical endpoints, knowledge on reference range (RR) methodology and determinants of gestational hCG levels is crucial. Moreover, a better understanding of gestational hCG physiology can improve current screening programs and future clinical management. Serum total hCG levels were determined in 8195 women participating in the Generation R Study. Gestational age specific RRs using 'ultrasound derived gestational age' (US RRs) were calculated and compared with 'last menstrual period derived gestational age' (LMP RRs) and a model-based RR. We also investigated which pregnancy characteristics were associated with hCG levels. Compared to the US RRs, the LMP RRs were lower, most notably for the median and lower limit levels. No considerable differences were found between RRs calculated in the general population or in uncomplicated pregnancies only. Maternal smoking, BMI, parity, ethnicity, fetal gender, placental weight and hyperemesis gravidarum symptoms were associated with total hCG. We provide gestational RRs for total hCG and show that total hCG values and RR cut-offs during pregnancy vary depending on pregnancy dating methodology. This is likely due to the influence of hCG on embryonic growth, suggesting that ultrasound based pregnancy dating might be less reliable in women with high/low hCG levels. Furthermore, we identify different pregnancy characteristics that influence total hCG levels considerably and should therefore be accounted for in clinical studies.

  11. Analytical and Clinical Validation of the Immulite 1000 hCG Assay for Quantitative Analysis in Urine

    Science.gov (United States)

    Cate, Frances L.; Moffett, Courtney; Gronowski, Ann M.; Grenache, David G.; Hartmann, Katherine E.; Woodworth, Alison

    2013-01-01

    Background The Siemens Immulite hCG assay detects all major hCG variants in serum. Currently, this assay is only FDA approved for qualitative measurement of hCG in urine. Methods Complete validation of the hCG assay in urine was performed on the Siemens Immulite 1000 immunoassay platform. Reference intervals were established for females hCG assay was precise for measuring hCG in urine from pregnant patients with intra- and inter-assay imprecision of hCG and hCGβ respectively. The assay was non-linear for hCGβcf. No hook effect was observed at concentrations up to 1,200,000 pmol/l, for hCGβ or hCGβcf. The reference intervals were hCG assay can accurately quantify hCG in urine. PMID:23470427

  12. The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence

    Science.gov (United States)

    Makrigiannakis, Antonis; Vrekoussis, Thomas; Zoumakis, Emmanouel; Kalantaridou, Sophia N.; Jeschke, Udo

    2017-01-01

    Embryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pathways within the decidua contributing to endometrial receptivity. Herein, a brief overview of the molecular mechanisms regulated by HCG is presented. Furthermore, we summarize the existing evidence regarding the clinical impact on reproductive outcomes after endometrial priming with HCG prior to embryo transfer. Although promising, further evidence is needed to clarify the protocol that would lead to beneficial outcomes. PMID:28629172

  13. Biological functions of hCG and hCG-related molecules

    Directory of Open Access Journals (Sweden)

    Cole Laurence A

    2010-08-01

    Full Text Available Abstract Background hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic malignancies, and pituitary hCG made by the gonadotrope cells of the anterior pituitary. Results and discussion hCG has numerous functions. hCG promotes progesterone production by corpus luteal cells; promotes angiogenesis in uterine vasculature; promoted the fusion of cytotrophoblast cell and differentiation to make syncytiotrophoblast cells; causes the blockage of any immune or macrophage action by mother on foreign invading placental cells; causes uterine growth parallel to fetal growth; suppresses any myometrial contractions during the course of pregnancy; causes growth and differentiation of the umbilical cord; signals the endometrium about forthcoming implantation; acts on receptor in mother's brain causing hyperemesis gravidarum, and seemingly promotes growth of fetal organs during pregnancy. Hyperglycosylated hCG functions to promote growth of cytotrophoblast cells and invasion by these cells, as occurs in implantation of pregnancy, and growth and invasion by choriocarcinoma cells. hCG free beta-subunit is produced by numerous non-trophoblastic malignancies of different primaries. The detection of free beta-subunit in these malignancies is generally considered a sign of poor prognosis. The free beta-subunit blocks apoptosis in cancer cells and promotes the growth and malignancy of the cancer. Pituitary hCG is a sulfated variant of hCG produced at low levels during the menstrual cycle. Pituitary hCG seems to mimic luteinizing hormone actions during the menstrual cycle.

  14. Biological functions of hCG and hCG-related molecules

    Science.gov (United States)

    2010-01-01

    Background hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic malignancies, and pituitary hCG made by the gonadotrope cells of the anterior pituitary. Results and discussion hCG has numerous functions. hCG promotes progesterone production by corpus luteal cells; promotes angiogenesis in uterine vasculature; promoted the fusion of cytotrophoblast cell and differentiation to make syncytiotrophoblast cells; causes the blockage of any immune or macrophage action by mother on foreign invading placental cells; causes uterine growth parallel to fetal growth; suppresses any myometrial contractions during the course of pregnancy; causes growth and differentiation of the umbilical cord; signals the endometrium about forthcoming implantation; acts on receptor in mother's brain causing hyperemesis gravidarum, and seemingly promotes growth of fetal organs during pregnancy. Hyperglycosylated hCG functions to promote growth of cytotrophoblast cells and invasion by these cells, as occurs in implantation of pregnancy, and growth and invasion by choriocarcinoma cells. hCG free beta-subunit is produced by numerous non-trophoblastic malignancies of different primaries. The detection of free beta-subunit in these malignancies is generally considered a sign of poor prognosis. The free beta-subunit blocks apoptosis in cancer cells and promotes the growth and malignancy of the cancer. Pituitary hCG is a sulfated variant of hCG produced at low levels during the menstrual cycle. Pituitary hCG seems to mimic luteinizing hormone actions during the menstrual cycle. PMID:20735820

  15. Her2+ and b-HCG Producing Undifferentiated Gastric Adenocarcinoma.

    Science.gov (United States)

    Eivaz-Mohammadi, Sahar; Gonzalez-Ibarra, Fernando; Abdul, Waheed; Tarar, Omer; Malik, Khurram; Syed, Amer K

    2014-01-01

    A 25-year-old Hispanic female with a history of anemia, schizoaffective disorder, and psychosis was admitted for anemia associated with fatigue, weakness, shortness of breath, night sweats, weight loss, and abdominal and lower back pain for the past two months. On routine management, she was found to have a positive serum b-HCG of 80.4 (0-5 mIU/mL) but the patient denied any sexual activity in her life. During her admission, U/S of the pelvis was noncontributory. CT angiogram of the chest was significant for prominent mediastinal and hilar lymph nodes, diffusely thickened stomach suggesting gastric malignancy with multiple hypoenhancing lesions in the liver and diffuse lytic lesions in the spine and sacrum suspicious for metastatic disease. The MRI of the abdomen confirmed the CT angiogram findings. After these findings, EGD was performed which showed lesions in the antrum, body of the stomach, fundus, and cardia on the lesser curvature of the stomach body correlating with carcinoma. The biopsy was positive for Her2, b-HCG producing poorly differentiated gastric adenocarcinoma. Patient underwent one successful round of chemotherapy with Taxotene, Cisplatin, and 5-FU for Stage IV gastric adenocarcinoma.

  16. Urinary hyperglycosylated hCG in first trimester screening for chromosomal abnormalities

    NARCIS (Netherlands)

    Butler, SA; Mantingh, A; Cole, LA

    2000-01-01

    Hyperglycosylated human chorionic gonadotrophin (H-hCG), also known as Invasive Trophoblast Antigen or ITA, is a unique metabolic variant of hCG with more complex oligosaccharide side chains. Concentrations are independent of regular hCG. Urine H-hCG has recently proved to be a highly sensitive mark

  17. Urinary hyperglycosylated hCG in first trimester screening for chromosomal abnormalities

    NARCIS (Netherlands)

    Butler, SA; Mantingh, A; Cole, LA

    2000-01-01

    Hyperglycosylated human chorionic gonadotrophin (H-hCG), also known as Invasive Trophoblast Antigen or ITA, is a unique metabolic variant of hCG with more complex oligosaccharide side chains. Concentrations are independent of regular hCG. Urine H-hCG has recently proved to be a highly sensitive mark

  18. Myth vs. Fact: The Human Chorionic Gonadotropin (hCG) Diet

    Science.gov (United States)

    ... exactly is hCG? Human chorionic gonadotropin is a hormone produced during pregnancy to help nourish the growing fetus. The U.S. Food and Drug Administration (FDA) approved hCG for a number of medical uses. ... understand that hormones are powerful and must be prescribed with caution. ...

  19. Reference ranges and determinants of total hCG levels during pregnancy: the Generation R Study

    NARCIS (Netherlands)

    T.I.M. Korevaar (Tim); E.A.P. Steegers (Eric); Y.B. de Rijke (Yolanda); S. Schalekamp-Timmermans (S.); W.E. Visser (Wil Edward); A. Hofman (Albert); V.W.V. Jaddoe (Vincent); H.W. Tiemeier (Henning); T.J. Visser (Theo); M. Medici (Marco); R.P. Peeters (Robin)

    2015-01-01

    textabstractHuman chorionic gonadotropin (hCG) is a pregnancy hormone secreted by the placental synctiotrophoblast cell layer that has been linked to fetal growth and various placental, uterine and fetal functions. In order to investigate the effects of hCG on clinical endpoints, knowledge on refere

  20. Reference ranges and determinants of total hCG levels during pregnancy: the Generation R Study

    NARCIS (Netherlands)

    T.I.M. Korevaar (Tim); E.A.P. Steegers (Eric); Y.B. de Rijke (Yolanda); S. Schalekamp-Timmermans (S.); W.E. Visser (Wil Edward); A. Hofman (Albert); V.W.V. Jaddoe (Vincent); H.W. Tiemeier (Henning); T.J. Visser (Theo); M. Medici (Marco); R.P. Peeters (Robin)

    2015-01-01

    textabstractHuman chorionic gonadotropin (hCG) is a pregnancy hormone secreted by the placental synctiotrophoblast cell layer that has been linked to fetal growth and various placental, uterine and fetal functions. In order to investigate the effects of hCG on clinical endpoints, knowledge on refere

  1. hCG in screening for aneuploidy: a possible role for its glycoforms?

    Science.gov (United States)

    Brun, S; Leguy, M C; Bruneel, A; Fournier, T; Anselem, O; Guibourdenche, J

    2014-06-01

    Fetal trisomy 21 is associated with elevated maternal serum hCG and its free beta-subunit (hCG-beta) in vivo, and abnormal placental hCG production and glycosylation in vitro. Other maternal serum markers may also be disrupted in major aneuploidies (T21, T18, T13). We evaluated our aneuploidy screening practices, focusing on hCG-beta and hCG glycoforms, and retrospectively analyzed 55 aneuploidy cases diagnosed over a 2 year period, determining maternal serum hCG glycoforms profiles using 2D-electrophoresis. Screening efficiency reached 96.7%. T21 was associated with elevated hCG-beta while T18 presented with diminished serum markers. hCG glycoforms tended to be basic in aneuploidy (mainly T13). Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Photonic heterostructure High Contrast Grating as a novel polarization control and light confinement system in HCG VCSEL

    Science.gov (United States)

    Gebski, M.; Dems, M.; Chen, J.; Qijie, W.; Dao Hua, Z.; Czyszanowski, T.

    2014-05-01

    In this paper we present results of computer optical simulations of VCSEL with modified high refractive index contrast grating (HCG) as a top mirror. We consider the HCG of two different designs which determine the lateral aperture. Such HCG mirror provides selective guiding effect. We show that proper design of aperture of HCG results in almost sixfold increase in cavity Q-factor for zero order mode and a discrimination of higher order modes.

  3. GnRHa trigger and individualized luteal phase hCG support according to ovarian response to stimulation

    DEFF Research Database (Denmark)

    Al Humaidan, Peter Samir Heskjær; Polyzos, N P; Alsbjerg, B

    2013-01-01

    STUDY QUESTION: Does a GnRH agonist (GnRHa) trigger followed by a bolus of 1.500 IU hCG in a group of patients at risk of ovarian hyperstimulation syndrome (OHSS) reduce the OHSS incidence compared with hCG trigger? SUMMARY ANSWER: A GnRHa trigger followed by early luteal hCG support with one bolus...

  4. The effect of intrauterine HCG injection on IVF outcome: a systematic review and meta-analysis.

    Science.gov (United States)

    Osman, A; Pundir, J; Elsherbini, M; Dave, S; El-Toukhy, T; Khalaf, Y

    2016-09-01

    In this systematic review and meta-analysis, the effect of intrauterine HCG infusion before embryo transfer on IVF outcomes (live birth rate, clinical pregnancy rate and spontaneous aboretion rate) was investigated. Searches were conducted on MEDLINE, EMBASE and The Cochrane Library. Randomized studies in women undergoing IVF and intracytoplasmic sperm injection comparing intrauterine HCG administration at embryo transfer compared with no intrauterine HCG were eligible for inclusion. Eight randomized controlled trials were eligible for inclusion in the meta-analysis. A total of 3087 women undergoing IVF and intracytoplasmic sperm injection cycles were enrolled (intrauterine HCG group: n = 1614; control group: n = 1473). No significant difference was found in the live birth rate (RR 1.13; 95% CI 0.84 to 1.53) and spontaneous abortion rate (RR 1.00, 95% CI 0.74 to 1.34) between women who received intrauterine HCG and those who did not receive HCG. Although this review was extensive and included randomized controlled trials, no significant heterogeneity was found, and the overall included numbers are relatively small. In conclusion the current evidence does not support the use of intrauterine HCG administration before embryo transfer. Well-designed multicentre trials are needed to provide robust evidence.

  5. Luteal phase HCG support for unexplained recurrent pregnancy loss - a low hanging fruit?

    Science.gov (United States)

    Fox, Chelsea; Azores-Gococo, Denise; Swart, Linda; Holoch, Kristin; Savaris, Ricardo F; Likes, Creighton E; Miller, Paul B; Forstein, David A; Lessey, Bruce A

    2017-03-01

    Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies and accounts for only 1-5% of pregnancy failures. Treatment options for unexplained RPL (uRPL) are limited. Previous studies suggest a link between delayed implantation and pregnancy loss. Based on this, a timely signal for rescue of the corpus luteum (CL) using human chorionic gonadotrophin (HCG) could improve outcomes in women with uRPL. This retrospective cohort study included 98 subjects with uRPL: 45 underwent 135 monitored cycles without HCG support; and 53 underwent 142 cycles with a single mid-luteal HCG injection. Based on Log-rank Mantel-Cox survival curves, miscarriage rate and time to pregnancy decreased in the HCG group (P = 0.0005). Women receiving luteal HCG support had an increased chance of an ongoing pregnancy compared with those not receiving it (RR = 2.4; 95% CI 1.4-3.6; number need to treat (NNT) = 7; 95% CI 4-18). Subjects receiving HCG support had a significant absolute risk reduction (ARR) of miscarriage (P HCG in women with RPL appears warranted. Copyright © 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  6. Hyperglycosylated hCG: a Unique Human Implantation and Invasion Factor.

    Science.gov (United States)

    Evans, Jemma

    2016-03-01

    Human chorionic gonadotropin (hCG), as one of the first embryonic products, has been extensively investigated for its role in implantation and placental development. Discovery of an over-glycosylated form of this hormone, hyperglycosylated hCG (hCG-H), has provided an additional level of complexity in our understanding of the implantation and placentation process; the structure, activity and functional implications of alterations in hCG isoforms throughout pregnancy are still being characterized. HCG-H comprises up to 90% of total hCG measurable in serum and urine during the first 2-3 weeks of pregnancy when invasive trophoblast activity is high, dropping to negligible proportions, less than 5%, of total hCG at the end of the first trimester. Functionally, hCG-H promotes trophoblast invasion during early pregnancy and has potential roles in immune cell modulation and endothelial function within the uterus at the time of pregnancy initiation. Altered levels of hCG-H are characteristics of pregnancy complications of altered trophoblast function and inadequate placentation, such as pre-eclampsia, and also over-abundance of invasive cytotrophoblasts, such as Down's syndrome. Improving our basic knowledge of the functional role-specific hCG isoforms plays in the complex cascade of events involved in implantation and placental development, and determining dynamic changes in the structure and activity of hCG isoforms throughout gestation will facilitate evidence-based decisions in assisted reproduction/in vitro fertilization based on the potential of embryos to implant, provide biomarkers for diagnosis of pregnancy complications associated with altered placental development and enhance understanding of how hCG isoforms may influence receptivity of the endometrium. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Potential role of hCG in apoptosis of human luteinized granulosa cells

    Science.gov (United States)

    HIRATA, Rei; HOJO, Takuo; SANO, Masahiro; HAYASHI, Nobuyoshi; OKUDA, Kiyoshi

    2014-01-01

    The corpus luteum (CL) forms after ovulation and acts as a temporary endocrine gland that produces progesterone (P4), a hormone that is essential for implantation and maintenance of pregnancy in mammals. In pregnant women, human chorionic gonadotropin (hCG) secreted by the conceptus prevents luteolysis. hCG also increases the survival of cultured human luteinized granulosa cells (hLGCs). To clarify the maintenance mechanism of the human CL, we investigated the effects of hCG and P4 receptor antagonists, onapristone (OP) and RU486, on the viability of hLGCs. With the patients’ consent, hLGCs were isolated from follicular aspirates for in vitro fertilization. The cells were cultured with hCG (0.1, 1, 10, 100 IU/ml), OP (10, 25, 50, 100 μM), RU486 (100 μM), P4 (1, 10, 25, 50 μM) or some combination of the four for 24 h. Cell viability was significantly increased by hCG (100 IU/ml) and significantly decreased by OP (100 μM) compared with the control. Cells treated with hCG and OP together were significantly less viable than the control and OP-treated cells. The combined treatment also significantly increased CASP3 activity and cleaved CASP3 protein expression. Furthermore, P4 addition reversed the reduction in cell viability caused by the combination of hCG and OP treatment. The overall findings suggest that hCG cooperates with P4 to increase survival of hLGCs and to induce apoptosis when P4 action supported by hCG is attenuated in the human CL. PMID:25451535

  8. HCG-Activated Human Peripheral Blood Mononuclear Cells (PBMC) Promote Trophoblast Cell Invasion.

    Science.gov (United States)

    Yu, Nan; Yan, Wenjie; Yin, Tailang; Wang, Yaqin; Guo, Yue; Zhou, Danni; Xu, Mei; Ding, Jinli; Yang, Jing

    2015-01-01

    Successful embryo implantation and placentation depend on appropriate trophoblast invasion into the maternal endometrial stroma. Human chorionic gonadotropin (hCG) is one of the earliest embryo-derived secreted signals in the peripheral blood mononuclear cells (PBMC) that abundantly expresses hCG receptors. The aims of this study were to estimate the effect of human embryo-secreted hCG on PBMC function and investigate the role and underlying mechanisms of activated PBMC in trophoblast invasion. Blood samples were collected from women undergoing benign gynecological surgery during the mid-secretory phase. PBMC were isolated and stimulated with or without hCG for 0 or 24 h. Interleukin-1β (IL-1β) and leukemia inhibitory factor (LIF) expressions in PBMC were detected by enzyme-linked immunosorbent assay and real-time polymerase chain reaction (PCR). The JAR cell line served as a model for trophoblast cells and was divided into four groups: control, hCG only, PBMC only, and PBMC with hCG. JAR cell invasive and proliferative abilities were detected by trans-well and CCK8 assays and matrix metalloproteinase (MMP)-2 (MMP-2), MMP-9, vascular endothelial growth factor (VEGF), tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 expressions in JAR cells were detected by western blotting and real-time PCR analysis. We found that hCG can remarkably promote IL-1β and LIF promotion in PBMC after 24-h culture. PBMC activated by hCG significantly increased the number of invasive JAR cells in an invasion assay without affecting proliferation, and hCG-activated PBMC significantly increased MMP-2, MMP-9, and VEGF and decreased TIMP-1 and TIMP-2 expressions in JAR cells in a dose-dependent manner. This study demonstrated that hCG stimulates cytokine secretion in human PBMC and could stimulate trophoblast invasion.

  9. Standardization of Epitopes for Human Chorionic Gonadotropin (hCG) Immunoassays.

    Science.gov (United States)

    Berger, Peter; Lapthorn, Adrian J

    2016-01-01

    hCG and its variants are markers for pregnancy tests, pregnancyrelated complications, trophoblastic diseases, pre-natal screening of Down's syndrome and doping controls. Strong demands are imposed on diagnostic methods by the dynamic changes in the absolute and relative levels of hCG protein backbone variants and glycosylation isoforms in serum and urine during development of pregnancy or the progression/remission of tumors. Observed differences in the results between commercial diagnostic immunoassays reflect the unequal molar recognition of the different metabolic hCG variants, in particular the hCG beta core fragment (hCGβcf), by the diagnostic antibodies (Abs), as their epitopes are not standardized, and the fact that suboptimal hCG standards are used. To rapidly characterize Abs by their epitope recognition and specificity to evaluate their suitability for diagnostic immunoassays a procedure of comparative epitope mapping has been developed using epitope-defined reference Abs. Comparative epitope mapping of diagnostic Abs will provide the basis for the standardization of diagnostic antigenic domains/epitopes and consequently for improved reliability of hCG measurements. Diagnostic first line assays likely consist of pairs of Abs that recognize specific epitopes at the top of the neighboring peptide loops 1 and 3 (Ł1+3) and the cystine knot (ck) of hCGβ, respectively. In future, significant improvements of reliability, robustness and comparability of the results of immunoassays for complex glycoproteins such as hCG will be achieved by the use (i) of standardized diagnostic Abs against welldefined epitopes and (ii) of the new International Standards for hCG and for five hCG variants established by WHO, that are calibrated in molar (SI) units.

  10. Dirofilariose pulmonar humana: relato de sete casos

    OpenAIRE

    CAVALLAZZI RODRIGO SILVA; CAVALLAZZI ANTÔNIO CÉSAR; SOUZA IRENE VIEIRA; CARDOSO JOÃO JOSÉ DE DEUS

    2002-01-01

    Dirofilariose pulmonar humana é uma doença rara causada pelo parasita Dirofilaria immitis. Apresenta-se usualmente como um nódulo pulmonar solitário que mimetiza câncer de pulmão. Embora considerada uma doença clinicamente benigna, uma biópsia pulmonar excisional é quase sempre necessária para o diagnóstico. Relatam-se as características epidemiológicas, clínicas e radiológicas de sete casos de dirofilariose pulmonar humana em Florianópolis. De sete pacientes relatados, seis tiveram como acha...

  11. Reprodução Humana

    Directory of Open Access Journals (Sweden)

    José Eduardo De Siqueira

    2007-01-01

    Full Text Available Los avances producidos por los modernos métodos de control de la natalidad y de la fertilización humana asistida introdujeron en la reflexión ética nuevos valores como dignidad personal,autonomia y paternidad responsable. Loa antíguos preceptos de sumisión a la moralidad heterogénea de la Ley Natural fueronsustituidos por una ética de reflexión autónoma en los campos de la sexualidad y reproducción humana asistida.

  12. Comparison of triple-risk assessment of fetal trisomy 21 including total human choriogonadotropin (hCG) or its free beta-subunit (free beta hCG).

    Science.gov (United States)

    Sancken, U; Bahner, D

    2003-01-01

    Second trimester total hCG and free betahCG levels in maternal serum samples of 33 pregnancies affected by fetal trisomy 21 and of 188 matched controls were compared in a retrospective study. To find out differences of discriminating efficacy by using one of these markers a multivariate discriminant analysis was performed. Statistical evaluation was performed for hCG/free betahCG frequency distributions. Discriminant analysis was carried out using the status 'affected' or 'unaffected' as the group variable and the serum markers unconjugated estriol (uE3), alpha-fetoprotein (AFP), and alternatively, hCG or free betahCG, as discriminant variables. The median of free betahCG MoM values in affected pregnancies was slightly higher (1.90 MoM) than the median of total hCG MoM values (1.72 MoM) but a lower standard deviation was stated for the logarithmic hCG MoM values (SD = 0.49) compared with free betahCG MoM values (SD = 0.51). A two-tailed Student's t test revealed no significant differences of hCG and free betahCG MoM values in both the affected and unaffected pregnancies. By inclusion of free betahCG the discriminant analysis classified 26 out of 33 affected cases correctly and 45 out of 188 unaffected cases incorrectly. For the inclusion of hCG these ratios were 25/33 and 41/188, respectively. Taking in account the individual maternal age risks at a defined false-positive rate of 5% including free betahCG yielded a higher detection rate than including hCG. However, using 1:380 (age-related at-term risk of a 35-year-old woman) as a cut-off risk including hCG yielded a higher detection rate than including free betahCG. For the observed cases none of the markers, hCG or free betahCG, was superior in Down syndrome screening. Copyright 2003 S. Karger AG, Basel

  13. Evaluation and significance of hyperchromatic crowded groups (HCG) in liquid-based paps

    Science.gov (United States)

    Chivukula, Mamatha; Austin, R Marshall; Shidham, Vinod B

    2007-01-01

    Objective Hyperchromatic crowded groups (HCG), a term first introduced into the cytology literature by DeMay in 1995, are commonly observed in Pap tests and may rarely be associated with serious but difficult to interpret lesions. In this study, we specifically defined HCG as dark crowded cell groups with more than 15 cells which can be identified at 10× screening magnification. Methods We evaluated consecutive liquid-based (Surepath) Pap tests from 601 women (age 17–74 years, mean age 29.4 yrs) and observed HCG in 477 cases. In all 477 HCG cases, Pap tests were found to be satisfactory and to contain an endocervical sample. HCG were easily detectible at 10× screening magnification (size up to 400 um, mean 239.5 um) and ranged from 1 to 50 (mean 19.5) per Pap slide. Results HCG predominantly represented 3-Dimensional groups of endocervical cells with some nuclear overlap (379/477 – 79%), reactive endocervical cells with relatively prominent nucleoli and some nuclear crowding (29/477 – 6%), clusters of inflammatory cells (25/477 – 5.2%), parabasal cells (22/477 – 4.6%), endometrial cells (1/477 – 0.2%). Epithelial cell abnormalities (ECA) were present in only 21 of 477 cases (4.6%). 18 of 21 women with HCG-associated ECA were less than 40 years old; only 3 were =/> 40 years. HCG-associated final abnormal Pap test interpretations were as follows: ASCUS (6/21 – 28%), LSIL (12/21 – 57%), ASC-H (2/21 – 9.5%), and HSIL/CIN2-3 (3/21 – 14%). The association of HCG with ECA was statistically significant (p = 0.0174. chi-square test). In patients with ECA, biopsy results were available in 10 cases, and 4 cases of biopsy-proven CIN2/3 were detected. Among these four cases, HCG in the Pap tests, in retrospect represented the lesional high grade cells in three cases (one HSIL case and two ASC-H cases). Interestingly, none of the 124 cases without HCG were found to have an epithelial cell abnormality. Conclusion We conclude: a. HCG are observed in a high

  14. Decreased levels of genuine large free hCG alpha in men presenting with abnormal semen analysis

    Directory of Open Access Journals (Sweden)

    Plas Eugen

    2011-08-01

    Full Text Available Abstract Background The pregnancy hormone human chorionic gonadotropin (hCG and its free subunits (hCG alpha, hCG beta are produced in the male reproductive tract and found in high concentrations in seminal fluid, in particular hCG alpha. This study aimed to elucidate changes in peptide hormone profiles in patients showing abnormal semen analyses and to determine the genuineness of the highly abundant hCG alpha. Methods Seminal plasma was obtained from 45 male patients undergoing semen analysis during infertility workups. Comprehensive peptide hormone profiles were established by a panel of immunofluorometric assays for hCG, hCG alpha, hCG beta and its metabolite hCG beta core fragment, placental lactogen, growth hormone and prolactin in seminal plasma of patients with abnormal semen analysis results (n = 29 versus normozoospermic men (n = 16. The molecular identity of large hyperglycosylated hCG alpha was analyzed by mass-spectrometry and selective deglycosylation. Results hCG alpha levels were found to be significantly lower in men with impaired semen quality (1346 +/- 191 vs. 2753 +/- 533 ng/ml, P = 0.022. Moreover, patients with reduced sperm count had reduced intact hCG levels compared with normozoospermic men (0.097 +/- 0.022 vs. 0.203 +/- 0.040 ng/ml, P = 0.028. Using mass-spectrometry, the biochemical identity of hCG alpha purified from seminal plasma was verified. Under non-reducing conditions in SDS-PAGE, hCG alpha isolated from seminal plasma migrated in a manner comparable with large free hCG alpha with an apparent molecular mass (Mr, app of 24 kDa, while hCG alpha dissociated from pregnancy-derived holo-hCG migrated at approximately 22 kDa. After deglycosylation with PNGase F under denaturing conditions, all hCG alpha variants showed an Mr, app of 15 kDa, indicating identical amino acid backbones. Conclusions The findings indicate a pathophysiological relevance of hCG, particularly its free alpha subunit, in spermatogenesis. The

  15. DEPENDIENTES Y RACIONALES: LA FAMILIA HUMANA

    Directory of Open Access Journals (Sweden)

    Alfredo Marcos Martínez

    2012-01-01

    Full Text Available Son muchos los conceptos que condicionan la bioética, que pueden hacer que prospere o naufrague. Nos centramos aquí en dos de ellos, a saber, el concepto de dependencia, que funciona como necesario complemento del de autonomía, y el concepto de familia humana, que tal vez debería funcionar como sustituto en contextos morales del de especie humana. Ambos remiten en el fondo a otro concepto, de larga tradición filosófica, el de naturaleza humana, que ha vuelto al centro del debate en los últimos años. La modernidad puede ser caracterizada como una búsqueda de la autonomía. La autonomía en muchos sentidos es un objetivo justo y deseable. Sin embargo, el énfasis unilateral en la autonomía ha generado una antropología parcial. De ahí la importancia de pensar también una antropología de la dependencia que vincule a los miembros de la familia humana.

  16. Concepto integral de la persona humana

    OpenAIRE

    Giraldo Angel, Jorge

    2012-01-01

    EI concepto de la persona humana es de fundamental interés práctico. Se trata no del hombre en general o sea, considerado bajo el aspecto genérico-específico, sino de «este» hombre-individuo, concreto y singular. Por este aspecto, el hombre es una unidad individual psicosomática.

  17. Presence of. beta. hCG mRNA in the human pituitary

    Energy Technology Data Exchange (ETDEWEB)

    van Strien, A.; van Wezenbeek, P. (Organon International BV, Oss (Netherlands))

    1989-07-11

    A strong structural and biological similarity exist between human chorionic gonadotropin (hCG) and luteinizing hormone (LH). They share the same {alpha} subunit and have evolutionary related {beta} subunits. hCG is synthesized in first trimester placenta, whereas LH is synthesized in the pituitary. Substances with immunological, physical and biological properties of hCG have, however, been observed in postmenopausal urinary gonadotropin preparations as well as in pituitary extracts. Despite this finding it has not yet been proven that the hCG-like material is identical to placental hCG. This report describes the presence of a minor messenger RNA species in the human pituitary. RNA was isolated from five human pituitary glands and an amplified cDNA library was prepared.

  18. Early serum human chorionic gonadotropin (hCG) trends after medication abortion.

    Science.gov (United States)

    Pocius, Katherine D; Maurer, Rie; Fortin, Jennifer; Goldberg, Alisa B; Bartz, Deborah

    2015-06-01

    Despite increased reliance on human chorionic gonadotropin (hCG) for early pregnancy monitoring, there is limited information about hCG trends soon after medication abortion. The purpose of this study was to determine if there is a predictable decline in serum hCG values shortly after medication abortion. This is a retrospective study of women with early intrauterine pregnancies who underwent medication abortion with mifepristone and misoprostol and had a serum hCG level on Day 1 (day of mifepristone) and a repeat value on Day 2 to 6. The percent hCG decline was calculated from baseline to repeat measure, with repeat values from the same patient accounted for through repeated measure analysis of variance. Eighty-eight women with a mean gestational age of 5.5 weeks and median baseline hCG of 5220 IU met study criteria over a 3-year period. The mean decline (±SD) in hCG from the Day 1 baseline value was 56.9%±29.5% on Day 3, 73.5%±38.6% on Day 4, 86.1%±8.8% on Day 5, and 92.9%±3.4% on Day 6. Eighty-two women (93% of the cohort) had a complete abortion without further intervention. The least square means hCG decline among these women was 57.6% [95% confidence interval (CI): 50.3-64.9%] on Day 3, 78.9% (95% CI: 75.0-82.8%) on Day 4 and 86.2% (95% CI: 81.3-91.1%) on Day 5. There is a rapid decline in serum hCG within the first few days after early medication abortion. Further research is needed to delineate how soon after medication abortion this decline may be specific enough to confirm abortion completion. This study provides the largest cohort of patients followed with serial hCG values in the first few days after medication abortion. Our findings demonstrate the trend in hCG decline in this population, which may be predictable by Day 5. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Galaxy interactions in compact groups - II. Abundance and kinematic anomalies in HCG 91c

    Science.gov (United States)

    Vogt, Frédéric P. A.; Dopita, Michael A.; Borthakur, Sanchayeeta; Verdes-Montenegro, Lourdes; Heckman, Timothy M.; Yun, Min S.; Chambers, Kenneth C.

    2015-07-01

    Galaxies in Hickson Compact Group 91 (HCG 91) were observed with the WiFeS integral field spectrograph as part of our ongoing campaign targeting the ionized gas physics and kinematics inside star-forming members of compact groups. Here, we report the discovery of H II regions with abundance and kinematic offsets in the otherwise unremarkable star-forming spiral HCG 91c. The optical emission line analysis of this galaxy reveals that at least three H II regions harbour an oxygen abundance ˜0.15 dex lower than expected from their immediate surroundings and from the abundance gradient present in the inner regions of HCG 91c. The same star-forming regions are also associated with a small kinematic offset in the form of a lag of 5-10 km s-1 with respect to the local circular rotation of the gas. H I observations of HCG 91 from the Very Large Array and broad-band optical images from Pan-STARRS (Panoramic Survey Telescope And Rapid Response System) suggest that HCG 91c is caught early in its interaction with the other members of HCG 91. We discuss different scenarios to explain the origin of the peculiar star-forming regions detected with WiFeS, and show that evidence points towards infalling and collapsing extraplanar gas clouds at the disc-halo interface, possibly as a consequence of long-range gravitational perturbations of HCG 91c from the other group members. As such, HCG 91c provides evidence that some of the perturbations possibly associated with the early phase of galaxy evolution in compact groups impact the star-forming disc locally, and on sub-kpc scales.

  20. A curva de regressão da gonadotrofina coriônica humana é útil no diagnóstico precoce da neoplasia trofoblástica gestacional pós-molar? Are curves of human chorionic gonadotropin useful in the early diagnosis of post-molar trophoblastic neoplasia?

    Directory of Open Access Journals (Sweden)

    Lúcia Regina Marques Gomes Delmanto

    2007-10-01

    Full Text Available OBJETIVO: avaliar a utilidade da curva de regressão normal da gonadotrofina coriônica humana (hCG no diagnóstico precoce de neoplasia trofoblástica gestacional pós-molar (NTG. MÉTODOS: estudo longitudinal, incluindo 105 pacientes com mola hidatiforme completa (MHC acompanhadas no Centro de Doenças Trofoblásticas de Botucatu, entre 1998 e 2005. Os títulos da hCG sérica foram mensurados quinzenalmente em todas as pacientes. Curvas individuais de regressão da hCG das 105 pacientes foram estabelecidas. A comparação entre a curva de regressão normal estabelecida em nosso serviço com as curvas individuais da hCG foi usada no rastreamento e diagnóstico (platô/ascensão de NTG. O número de semanas pós-esvaziamento quando a hCG excedeu o limite normal foi comparado com o número semanas em que a hCG apresentou platô/ascensão. RESULTADOS: das 105 pacientes com MHC, 80 apresentaram remissão espontânea (RE e 25 desenvolveram NTG. Das 80 pacientes com RE, 7 (8,7% apresentaram, inicialmente, dosagem da hCG acima do normal, mas, no devido tempo, alcançaram a remissão. Todas as 25 pacientes com NTG apresentaram desvio da curva normal da hCG em 3,8±2,5 semanas e mostraram platô ou ascensão em 8,4±2,9 semanas (pPURPOSE: to evaluate the usefulness of the normal human chorionic gonadotropin (hCG regression curve in the early diagnosis of post-molar trophoblastic neoplasia (GTN. METHODS: a longitudinal study including 105 patients with complete hydatidiform mole (CHM followed up at the Botucatu Center of Trophoblastic Diseases from 1998 to 2005. Serial serum hCG titers were measured fortnightly in all patients. Individual curves of the 105 patients were built. Comparison between the normal regression curve established at our center with individual hCG curves was used to screen and diagnose (plateau/rise GTN. The number of weeks postevacuation when hCG levels exceeded the normal limits was compared with the number of weeks when hCG

  1. Galaxy Interactions in Compact Groups II: abundance and kinematic anomalies in HCG 91c

    CERN Document Server

    Vogt, F P A; Borthakur, S; Verdes-Montenegro, L; Heckman, T M; Yun, M S; Chambers, K C

    2015-01-01

    Galaxies in Hickson Compact Group 91 (HCG 91) were observed with the WiFeS integral field spectrograph as part of our ongoing campaign targeting the ionized gas physics and kinematics inside star forming members of compact groups. Here, we report the discovery of HII regions with abundance and kinematic offsets in the otherwise unremarkable star forming spiral HCG 91c. The optical emission line analysis of this galaxy reveals that at least three HII regions harbor an oxygen abundance ~0.15 dex lower than expected from their immediate surroundings and from the abundance gradient present in the inner regions of HCG 91c. The same star forming regions are also associated with a small kinematic offset in the form of a lag of 5-10 km/s with respect to the local circular rotation of the gas. HI observations of HCG 91 from the Very Large Array and broadband optical images from Pan-STARRS suggest that HCG 91c is caught early in its interaction with the other members of HCG 91. We discuss different scenarios to explain...

  2. Induksi Superovulasi dengan Kombinasi CIDR, Hormon FSH dan hCG pada Induk Sapi Potong

    Directory of Open Access Journals (Sweden)

    E.M. Kaiin

    2006-12-01

    Full Text Available The aim of this study was to evaluate the effect of superovulation treatment using combination of CIDR, FSH and hCG in beef cattle as donor embryos using MOET programme. All animals had been palpated to evaluated the ovary status and normal cows were used as donor and synchronized with CIDR (Eazy BreedTM . At day 10 of oestrus cycle, cows were divided into two groups, first group: cows were injected intramuscularly with FSH (Antrin 40 IU per cow with decreasing doses (for 4 days and second group cows were treated the same way but at day 5 after FSH injection, they were injected intramuscularly with 1,500 IU hCG (Chorulon. Embryo collection was done at day 7 after Artificial Insemination (AI. Average number of corpora lutea (CL in animals that superovulated with CIDR, FSH and hCG was significantly higher (P<0.05 compared to animals treated with CIDR and FSH only (5.52. Average number of embryo collection and number of transferable embryos were also higher in group treated with hCG (6.00 vs 5.44 compared with those treated without hCG (4.33 vs 3.17. The conclusion is hCG superovulation injection with CIDR and FSH can increase the respon of superovulation

  3. Combined ovulation triggering with GnRH agonist and hCG in IVF patients.

    Science.gov (United States)

    Kasum, Miro; Kurdija, Kristijan; Orešković, Slavko; Čehić, Ermin; Pavičić-Baldani, Dinka; Škrgatić, Lana

    2016-11-01

    The aim of the review is to analyse the combination of a gonadotrophin releasing hormone (GnRH) agonist with a human chorionic gonadotrophin (hCG) trigger, for final oocyte maturation in in vitro fertilisation (IVF) cycles. The concept being a ''dual trigger'' combines a single dose of the GnRH agonist with a reduced or standard dosage of hCG at the time of triggering. The use of a GnRH agonist with a reduced dose of hCG in high responders demonstrated luteal phase support with improved pregnancy rates, similar to those after conventional hCG and a low risk of ovarian hyperstimulation syndrome (OHSS). The administration of a GnRH agonist and a standard hCG in normal responders, demonstrated significantly improved live-birth rates and a higher number of embryos of excellent quality, or cryopreserved embryos. The concept of the ''double trigger" represents a combination of a GnRH agonist and a standard hCG, when used 40 and 34 h prior to ovum pick-up, respectively. The use of the ''double trigger" has been successfully offered in the treatment of empty follicle syndrome and in patients with a history of immature oocytes retrieved or with low/poor oocytes yield. Further prospective studies are required to confirm the aforementioned observations prior to clinical implementation.

  4. hCG stimulates angiogenic signals in lymphatic endothelial and circulating angiogenic cells.

    Science.gov (United States)

    Schanz, Andrea; Lukosz, Margarete; Hess, Alexandra P; Baston-Büst, Dunja M; Krüssel, Jan S; Heiss, Christian

    2015-08-01

    Human chorionic gonadotropin (hCG) has long been associated with the initiation and maintenance of pregnancy, where angiogenesis plays an important role. However, the function of hCG in angiogenesis and the recruitment of vascular active cells are not fully understood. In this study, the role of hCG and its receptor in circulating angiogenic and human endothelial cells, including lymphatic, uterine microvascular, and umbilical vein endothelial cells, was examined. Immunohistochemistry and immunoblot analysis were used to detect LH/hCG receptor expression and the expression of hCG-induced angiogenic molecules. HIF-1α was determined via ELISA and downstream molecules, such as CXCL12 and CXCR4, via real-time PCR. Chemotaxis was analyzed using Boyden chambers. Our results show that the LH/hCG receptor was present in all tested cells. Furthermore, hCG was able to stimulate LH/hCG-receptor-specific migration in a dose-dependent fashion and induce key angiogenic molecules, including HIF-1α, CXCL12, and CXCR4. In conclusion, our findings underscore the importance of hCG as one of the first angiogenic molecules produced by the conceptus. hCG itself alters endothelial motility, recruitment, and expression of pro-angiogenic molecules and may therefore play an important role in vascular adaption during implantation and early placental formation. Copyright © 2015. Published by Elsevier Ireland Ltd.

  5. Raiva humana no Brasil, 1992 - 2001

    OpenAIRE

    Francisco Anilton Alves Araujo

    2002-01-01

    O estudo caracteriza os aspectos epidemiológicos da raiva humana no Brasil, no período de 1992 a 2001 e visa avaliar tendências da enfermidade no país e contribuir para a proposição de medidas de controle. Para análise dos casos, foi utilizado o banco de dados do Sistema de Vigilância da Raiva Humana (VE6), e realizado estudo descritivo de 313 casos ocorridos no período de 1992 a 2001. Os resultados revelam a tendência de redução do número de casos ao longo do período estudado. O coeficiente ...

  6. Vida humana y luz de la palabra

    OpenAIRE

    Ruiz Ortiz, Fernando María

    2016-01-01

    La paraula de l´home, signe per excel·lència de la comunicació humana, ha estat considerada pels filòsofs des de l´anomenat “gir llingüístic” com allò que o és l´única realitat o bé constitueix un obstacle per accedir a l´èsser de les coses i manifestar la veritat. Pel contrari, en aquesta investigació es pretén estudiar sota la guia del pensament de Tomàs d´Aquino que la llum de la paraula és el fonament del perfeccionament de la vida humana en totes les seves dimensions i que el llenguatge ...

  7. GESTIÓN HUMANA: TENDENCIAS Y PERSPECTIVAS

    Directory of Open Access Journals (Sweden)

    JUAN GUILLERMO SALDARRIAGA RÍOS

    2008-01-01

    Full Text Available En este artículo se hace referencia a las tendencias y las perspectivas de gestión humana que se imponen en el mundo en la actualidad y que, a su manera, pretenden optimizar la administración del personal de la organización y contribuir al desarrollo e incremento de la productividad y la competitividad. Mediante la realización de un Estado del Arte se logran determinar algunas de las tendencias más relevantes en la actualidad y se concluye que, cada vez con mayor fuerza, dichas tendencias se sustentan en discursos que pretenden "rescatar" al ser humano dentro de la organización, lo que no necesariamente se traduce en los procesos de gestión humana que se realizan en las organizaciones nacionales e internacionales.

  8. Myiasis gastrointestinal humana por Eristalis tenax

    Directory of Open Access Journals (Sweden)

    Kun Marcelo

    1998-01-01

    Full Text Available Son caracterizadas las myiasis registradas en Bariloche y establecidas las condiciones probables bajo las cuales se produjeron las infestaciones. Las larvas obtenidas a partir de heces de 2 pacientes fueron identificadas como Eristalis tenax (Diptera: Syrphidae de acuerdo a las claves de Hartley (1961 y Organización Panamericana de la Salud (1962. Estos 2 casos de myiasis gastrointestinal humana constituyen los primeros registrados en Bariloche (Patagonia, Argentina y sus características responden a las registradas para esta especie de Díptera en otras partes del mundo. La falta de control específico en el sistema domiciliario de suministro de agua ha sido la causa más probable de la infestación. Este registro extiende la distribución de E. tenax y de las myiasis gastrointestinales humanas en América del Sur hasta los 41º 03' S.

  9. Application of immunomagnetic particles to enzyme-linked immunosorbent assay (ELISA) for improvement of detection sensitivity of HCG.

    Science.gov (United States)

    Kuo, Hsiao-Ting; Yeh, Jay Z; Wu, Po-Hua; Jiang, Chii-Ming; Wu, Ming-Chang

    2012-01-01

    This investigation was aimed at using superparamagnetic particles to enzyme-linked immunosorbent assay (SPIO-ELISA) of human chorionic gonadotropin (hCG) to enhance detection sensitivity of hCG. We found that N-(3-dimethyl aminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) was the best cross-linking reagent to link anti hCG α antibody to superparamagnetic particle (SPIO-anti hCG α antibody immunomagnetic particle). To improve the specificity of the assay, a horse radish peroxidase (HRP)-labeled anti-hCG beta monoclonal antibody was used to detect captured hCG using double antibody sandwich ELISA assay. SPIO-ELISA application to determine hCG increased the sensitivity to 1 mIU/mL, which is a level of sensitivity enabling the diagnosis of pregnancy during the early gestational period.

  10. Ehrliquiosis granulocitotrópica humana

    Directory of Open Access Journals (Sweden)

    José Rafael Rojas-Solano

    2007-04-01

    Full Text Available Las ehrliquiosis humanas son zoonosis emergentes transmitidas por varias especies de garrapatas e infectan gran cantidad de animales silvestres y domésticos. Reportamos el caso de un paciente con un cuadro clínico y hallazgos de laboratorio compatibles con una probable ehrliquiosis granulocitotrópica severa. El paciente se trató con doxicilina y respondió adecuadamente. Fue egresado en buena condición.

  11. The Effects of Anti-Hcg Monoclonal Antibodies on Human Cancer Cell Lines

    Directory of Open Access Journals (Sweden)

    Mirshahi M

    2011-12-01

    Full Text Available Background: Human cancer cell lines express human choriogonadotropin (hCG, its subunits and derivatives, regardless of their origin and type. It appears that hCG is a common phenotype in human cancer cell lines. In this research, the effects of hCG targeting monoclonal antibodies (7D9, T18H7 and T8B12 on human cancer cell lines were evaluated. Methods: Monoclonal antibody secreting hybridomas were proliferated and injected intraperitoneally to Balb/C mice after treatment with pristine. Two weeks later, ascites fluid was collected. Purification of aforementioned antibodies from ascites fluid was performed using G-protein affinity followed by ion exchange chromatography. SDS-PAGE and ELISA confirmed the structure and functional integrity of the purified antibodies, respectively. Two human cancer cell lines "Hela" and "MDA" were treated by the purified antibodies. Three days later, different wells were imaged and the cells counted. Results: SDS-PAGE gel (None-reducing indicated consistency of band migration patterns with control antibodies. ELISA test using hCG antigens indicated that the produced antibodies could detect hCG antigens. Cell lines were cultured and treated with different concentrations of each antibody. Counting and imaging different wells of treated plates, indicated that 7D9 antibody had a more significant (P<0.01 cytotoxic effect on cancer cell lines than the control cells. Conclusion: HCG targeting monoclonal antibodies can be used for targeted cancer therapy, as human cancer cells express hCG gene. 7D9 antibody that exhibits protease activity is a proper candidate for this purpose, as it possesses both antagonistic and enzymatic properties.

  12. Influence of hCG on inducible nitric oxide synthase gene expression in ram testicular arteries

    Directory of Open Access Journals (Sweden)

    Maria Matteo

    2014-09-01

    Full Text Available Background. Experimental evidence suggests a relationship between the vasodilatory effect of hCG and the NOS system in the testis. The influence of hCG administration on testicular vascular NOS gene expression has not been fully investigated. Objective: This study aimed to evaluate the presence of the nitric oxide syntheses gene in ram testicular arteries and the influence of hCG administration on its expression. Materials and methods: Both testicular arteries of sixteen rams were extracted before and after i.v. administration of 5000 IU of hCG or placebo. The expression of the iNOS gene was investigated by real time PCR. Data were analyzed by means of Wilcoxon and Mann-Whitney tests. A p value of < 0.05 was considered statistically significant. Results: PCR revealed the presence of iNOS mRNA in all basal samples but the expression of the iNOS gene was significantly reduced in all arteries obtained 24 h after the administration of either hCG or placebo. A significant reduction in the expression of iNOS gene was observed in the testicular arteries extracted after 24 h in both treated and placebo groups. On the other hand hCG stimulation did not significantly influence iNOS expression following its administration compared to a placebo. Conclusion: Ram testicular arteries express the iNOS gene but hCG stimulation did not significantly influence iNOS expression. A significant reduction in the expression of this gene was observed in the testicular arteries extracted after 24 h in both treated and placebo groups, suggesting that iNOS expression on the testicular artery could be influenced by the spermatic vessel ligation of the controlateral testis.

  13. The role of HCG increment in the 48h prior to methotrexate treatment as a predictor for treatment success.

    Science.gov (United States)

    Cohen, Aviad; Almog, Benny; Cohen, Yoni; Bibi, Guy; Rimon, Eli; Levin, Ishai

    2017-04-01

    To evaluate the role HCG change in the 48h prior to methotrexate treatment as a predictor for treatment success. Medical records of all women who were diagnosed with ectopic pregnancy between January 2001 and June 2013 were reviewed. Four hundred and nine patients received methotrexate due to ectopic pregnancy. The "single dose" methotrexate protocol with 50mg/m(2) was administered to patients with progressing ectopic pregnancy. HCG levels in days 1, 4 and 7 were used to evaluate methotrexate treatment success. The percentage of HCG change in the 48h prior to methotrexate treatment was compared between patients who were successfully treated and those who failed treatment with methotrexate. Single dose methotrexate was successful in 309 patients (75.4%, success group). The medians of HCG change in the 48h prior to methotrexate administration were significantly higher in the "failure group" (21% vs. 4%, pHCG percent increment prior to methotrexate administration was shown to be an independent predictor for treatment outcome. Receiver operator characteristic curve for HCG percent change was 0.751, at a cutoff value of HCG increment HCG increment in the 48h prior to methotrexate administration is an independent predictor for methotrexate treatment success. HCG increment <12% prior to methotrexate treatment is a good predictor for treatment success. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Urinary β-HCG in Benign and Malignant Urinary Tract Diseases

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    A.-B. Halim

    1994-01-01

    Full Text Available Detectable leve ls of HCG have been reported in conditions other th an normal pregnancy, including threatened abortion, ectopic pregnancy, trophoblastic tumors, carcinomas of the stomach, liver, pancreas and breast as well as multiple myeloma and melanoma. The present study was conducted to estimate urinary β-HCG in bladder cancer and benign urinary tract disorders. 163 individuals were included, 68 with bladder cancer (60 males and 8 females, 64 with benign urinary tract diseases (55 males and 9 females and 31 normal healthy controls (26 males and 5 females. Urinary β-HCG was estimated by the ELISA technique using the reagents supplied by DRG International Inc., Germany. Results of th e study revealed an overexpression of β-HCG in mali gnant and benign urinary tract diseases. 60.3% of the cancer patients and 29.7% of patients with benign diseases showed urinary β-HCG values above the upper limit of the control group (2mIU/ml .

  15. [Serum testosterone response to chorionic gonadotropin (HCG) injection in normal and cryptorchid children (author's transl)].

    Science.gov (United States)

    Fideleff, H L; Baigorri, A M; Guitelman, A; Hollander, T; Villuendas, V; Espínola, B

    1980-01-01

    Plasma testosterone (ng/ml) was measured in a group of prepuberal children with intrascrotal testes (n = 15) and in a group of prepuberal cryptorchid children (7 unilateral and 3 bilateral; n = 10) before and after stimulus with 3000IU of HCG (Group A) and with 5000IU (Group B). The serum testosterone before HCG stimulus was similar in normal (Group A: 1.10 +/- 0.03: Group B: 1.18 +/- 0.31) as well as in those of the cryptorchid children (Group A: 1 +/- 0.28; Group B: 1.19 +/- 0.36). The stimulus with 3000IU of HCG did not significantly raise the plasma testosterone in both normal (2.42 +/- 1.09) and cryptorchid children (1.70 +/- 0.5). The stimulus with 5000IU of HCG increased the plasma testosterone to 3.52 +/- 1 in normal children and 3.26 +/- 1.2 in cryptorchid children (p less than 0.05 with respect to the pre HCG values), with no difference in the response between the normal and the cryptorchid children.

  16. Serum human chorionic gonadotropin (hCG) trend within the first few days after medical abortion: a prospective study.

    Science.gov (United States)

    Pocius, Katherine D; Bartz, Deborah; Maurer, Rie; Stenquist, Asha; Fortin, Jennifer; Goldberg, Alisa B

    2017-03-01

    To prospectively describe the decline in serum human chorionic gonadotropin (hCG) in the first 5 days after complete medical abortion and evaluate the influence of initial hCG and gestational duration. We conducted a prospective, physiologic study of women ≤63 days gestation who underwent medical abortion with 200 mg mifepristone and 800 mcg buccal misoprostol. We stratified enrollment into two gestational cohorts, hCG values on Day 1 (day of mifepristone), Day 3, Day 5 and a routine follow up hCG on Days 7-14. We calculated the percent hCG decline from Day 1 to each repeat measure and evaluated trends based on initial serum hCG level and gestation. We enrolled 66 women; 59 were protocol-adherent and included in our analysis. Mean gestation on Day 1 was 49 days and mean baseline hCG was 72,332 IU. Fifty-seven subjects (97%) had a complete medical abortion without further intervention. The mean serum hCG decline among subjects with complete medical abortion was 70.0±10.6% [range 36.9-98.6%] on Day 3 and 91.4±4.4% [range 68.4-97.7%] on Day 5. The mean serum hCG decline from Day 1 to routine follow-up on Days 7-9 was 97.1±1.7% [range 92.4-99.2%], from Day 1 to Day 10-11 was 98.5±1.4% [range 94.7-99.6%] and from Day 1 to Day 12-14 was 98.7±2.8% [range 86.7-99.9%]. There was no difference in percent hCG decline stratified by initial hCG or gestation. There is a rapid and predictable decline in serum hCG as early as Day 5 after complete medical abortion through 63 days gestation. Rate of hCG decline is not affected by initial hCG or gestational duration. For women who require confirmation of complete abortion sooner than 1 week after mifepristone, due to patient preference, logistical constraints or in the setting of pregnancy of unconfirmed location, a single repeat hCG on Day 5 may be clinically useful. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Micro-dose hCG as luteal phase support without exogenous progesterone administration

    DEFF Research Database (Denmark)

    Andersen, C Yding; Fischer, R; Giorgione, V;

    2016-01-01

    For the last two decades, exogenous progesterone administration has been used as luteal phase support (LPS) in connection with controlled ovarian stimulation combined with use of the human chorionic gonadotropin (hCG) trigger for the final maturation of follicles. The introduction of the Gn......RHa trigger to induce ovulation showed that exogenous progesterone administration without hCG supplementation was insufficient to obtain satisfactory pregnancy rates. This has prompted development of alternative strategies for LPS. Augmenting the local endogenous production of progesterone by the multiple...... corpora lutea has been one focus with emphasis on one hand to avoid development of ovarian hyper-stimulation syndrome and, on the other hand, to provide adequate levels of progesterone to sustain implantation. The present study evaluates the use of micro-dose hCG for LPS support and examines the potential...

  18. First trimester maternal serum AFP and total hCG in aneuploidies other than trisomy 21.

    Science.gov (United States)

    Spencer, K; Heath, V; Flack, N; Ong, C; Nicolaides, K H

    2000-08-01

    Total human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) were measured in maternal serum at 10-14 weeks of gestation from 53 pregnancies affected by trisomy 18, 42 cases with trisomy 13, 46 with Turner's syndrome and 13 with other sex aneuploides. The only significant association was the finding of reduced levels of total hCG in cases of trisomy 18 and 13. The association of increased levels of AFP in cases of trisomy 18 with ventral wall defects and the slight increase in AFP in cases of sex chromosomal anomalies other than Turner's syndrome was found. AFP and total hCG are not likely to replace the markers free beta-hCG and PAPP-A in first trimester screening for chromosomal anomalies. Copyright 2000 John Wiley & Sons, Ltd.

  19. Fabrication of SiC membrane HCG blue reflector using nanoimprint lithography

    Science.gov (United States)

    Lai, Ying-Yu; Matsutani, Akihiro; Lu, Tien-Chang; Wang, Shing-Chung; Koyama, Fumio

    2015-02-01

    We designed and fabricated a suspended SiC-based membrane high contrast grating (HCG) reflectors. The rigorous coupled-wave analysis (RCWA) was employed to verify the structural parameters including grating periods, grating height, filling factors and air-gap height. From the optimized simulation results, the designed SiC-based membrane HCG has a wide reflection stopband (reflectivity (R) HCG reflectors were fabricated by nanoimprint lithography and two-step etching technique. The corresponding reflectivity was measured by using a micro-reflectivity spectrometer. The experimental results show a high reflectivity (R<90%), which is in good agreement with simulation results. This achievement should have an impact on numerous III-N based photonic devices operating in the blue wavelength or even ultraviolet region.

  20. Timing of IUI Treatment after hCG Administration 1-48 h Affecting Pregnancy Rate

    Institute of Scientific and Technical Information of China (English)

    Fan YANG; Zu-mei SHI; Hui JIN; Li-ping ZHU; Kun-ming LI; Jian-zhi YANG; Zhi-qin CHEN; Xiao-ming TENG; Hui-fen CHEN; Yu WANG

    2008-01-01

    Objective To compare the different time of administration of hCG affecting pregnancy rate of IUI. Methods A total of 189 infertile couples underwent 331 cycles of IUI with husband’s sperm.They were separated into 3 groups according to the time of hCG administration in IUI:hCG 1-23 h(group A):hCG 24-36 h (group B);hCG 37—48 h(group C). Results There were no statistical differences among 3 groups.None of the other relative factors,such as the female age,the different methods of ovulation and the cause of infertility,showed differences in pregnancy rate among 3 groups. Conclusion IUI can be performed any time after administration of hCG(1—48 h).

  1. La conciencia humana y el emergentismo

    OpenAIRE

    Braun, Ricardo; Universidad de Lima (Perú)

    2011-01-01

    En este ensayo se exploran los conceptos de conciencia y emergentismo, además de otros conceptos asociados al problema del origen y estatus metafísico y epistemológico de la conciencia humana. Se defiende la idea de que de ser viable la tesis del emergentismo como explicación del origen y características de la conciencia, esta tendría que ser un emergentismo fuerte a diferencia de otras alternativas. La teoría emergentista de D. Chalmers es analizada por ser una posición bastante discutida en...

  2. Periodismo de Frontera y Dignidad Humana

    OpenAIRE

    Cetina Presuel, Rodrigo; Gutiérrez Atala, Fernando (ed.); Corredoira y Alfonso, Loreto

    2017-01-01

    El presente libro explora cuál es el papel del Derecho y la Ética de la información en la protección de la dignidad humana, particularmente en relación con las actividades informativas que se dan en ámbitos transfronterizos, ya sea entre países colindantes o entre países y organizaciones que tienen influencia regional y en los asuntos internos de otros terceros países. Entre otros temas, el libro también mira hacia procesos de paz como el vivido en Colombia y por extensión analiza temas a...

  3. Metodologias multidimensionais em Ciências Humanas

    Directory of Open Access Journals (Sweden)

    Ruby Esther León Díaz

    2014-03-01

    Full Text Available Los cuestionamientos contemporáneos hechos a las ciencias humanas tienen como punto de partida la excesiva división disciplinar, aunada a la construcción de visiones deterministas y absolutas de la naturaleza, del ser humano, del espíritu, de las cosas, de las teorías y de los valores. El trabajo presentado por las docentes de la Pontificia Universidad Católica de São Paulo (PUC-SP apuntala sobre esos cuestionamientos desde la teoría de la complejidad del pensador judeo-francés Edgar Morin.

  4. Hidatidosis humana en el Perú

    OpenAIRE

    Luis Guerra Montero; María Ramírez Breña

    2015-01-01

    El objetivo de este trabajo ha sido conocer el estado de la hidatidosis humana, por la gran incidencia que presenta en nuestro país, principalmente en la región central andina. La recopilación de datos fue a partir de la revisión de fuentes primarias sobre epidemiología, el ciclo vital del parásito y del manejo del paciente afecto de Hidatidosis. Algunos hallazgos permiten afirmar que la hidatidosis es una enfermedad producida por el estado larval del cestodo Echinococcus del género Granulosu...

  5. Agonist trigger: what is the best approach? Agonist trigger and low dose hCG

    DEFF Research Database (Denmark)

    Humaidan, Peter; Al Humaidan, Peter Samir Heskjær

    2012-01-01

    Low-dose hCG supplementation after GnRH agonist trigger may normalize reproductive outcome while minimizing the occurrence of OHSS in high risk IVF patients. (Fertil Steril (R) 2012;97:529-30. (C) 2012 by American Society for Reproductive Medicine.)......Low-dose hCG supplementation after GnRH agonist trigger may normalize reproductive outcome while minimizing the occurrence of OHSS in high risk IVF patients. (Fertil Steril (R) 2012;97:529-30. (C) 2012 by American Society for Reproductive Medicine.)...

  6. Effect the administration of human chorionic gonadotrophin (hCG hormone following superovulation treatment in buffalo

    Directory of Open Access Journals (Sweden)

    Polmer Situmorang

    2005-12-01

    Full Text Available A numbers of studies had been reported to evaluate the effect of hormone for superovulation treatment in buffaloes, however the numbers of embryo recovered is still very small. One of the limiting factors which affect the numbers of embryo recovered is preovulatery LH concentration. The experiment was carried out to study the effect of hCG following superovulation treatments in buffaloes as an effort to increase the embryo recovered. Ten (10 buffaloes in three different genotypes (Riverine, swamp and its crosses were superovulated using follicle stimulating hormone (FSH. A total of 12 ml FSH (Folltropin was injected intramuscularry twice a day with 12 hours interval in a decreasing doses for 4 days (2.5, 2.5; 2.0, 2.0; 1.0, 1.0 and 0.5, 0.5 ml. Prostaglandin was injected intramuscularry 2 days after the first injection of FSH followed by administration of 500 IU hCG two days later. At the same days of administration of hCG, artificial insemination (AI using frozen semen was conducted and repeated again after 12 and 24 hours. Blood collecting was conducted 3 times a week for obtaining the progesteron level of plasma blood. Embryo was collected by non-surgically technique on day 6 of estrus cycle by flushing each horn of uterus with 500 ml Dubelco's Phosphat Buffer Saline (DBPS. Parameter recorded were diameter of ovary (DO, total corpus luteum (TCL, number of embryo collected (NE, percentage of recovery rate (%RR and peak progesteron level (PP. Administration of hCG significantly increase the response of buffalo to superovulation treatment. The mean of DO (cm, TCL, NE and RR (% was 4.0, 6.3, 2.1 and 37.2 and 4.5, 7.5, 3.9 and 48.1 for controll and 500 IU hCG respectively. The mean NE was significantly higher (P<0.05 in hCG than those control. The peak progesterone concentration was highly significant higher (P<0.01 in hCG (8.9 ng/ml than those control (6.8 ng/ml. Both left and right ovary gave a similar response to superovulation treatments. In

  7. GnRHa trigger for final oocyte maturation: is HCG trigger history?

    DEFF Research Database (Denmark)

    Humaidan, Peter; Alsbjerg, Birgit

    2014-01-01

    gonadotrophin (HCG) trigger. Early trials showed a severe luteal phase insufficiency after GnRHa trigger despite the application of standard luteal phase support protocols. Subsequent research has led to modifications of the luteal phase support, resulting in reproductive outcome comparable to that seen after...... HCG trigger in normal- and high-responders. GnRHa trigger facilitates a tailored approach to subsequent luteal phase support, taking into account the ovarian response to stimulation. In the future, GnRHa is likely to be used for trigger in all women co-treated with GnRH antagonists....

  8. The value of HCG serum concentrations after trigger in predicting pregnancy and live birth rates in IVF-ICSI.

    Science.gov (United States)

    Zhou, Jianjun; Wang, Shanshan; Wang, Bin; Wang, Junxia; Chen, Hua; Zhang, Ningyuan; Hu, Yali; Sun, Haixiang

    2015-06-01

    The aim of this study was to determine if an association existed between serum human chorionic gonadotrophin (HCG) level at 12 h after trigger and IVF and intracytoplasmic sperm (ICSI) treatment outcomes. Women undergoing initial IVF-ICSI and embryo transfer treatment using the long luteal phase gonadotrophin-releasing hormone agonist protocol between April 2012 and March 2013 for tubal factor were included (n = 699). In the clinical pregnancy group, HCG after trigger was significantly elevated (276.0 ± 5.1 versus 198.5 ± 6.1 mIU/mL; P HCG was 201.2 mIU/ml. Compared with the lower HCG group, the clinical pregnancy rate in the higher HCG group was increased in obese and non-obese patients (77.8% versus 57.3%, P HCG was associated with a better IVF-ICSI treatment outcome (OR 4.39, 95% CI 2.99 to 6.45). Clinical pregnancy rate was significantly higher across increasing quartiles of HCG. An elevated level of serum HCG at 12 h after trigger was associated with a better IVF-ICSI outcome. Copyright © 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  9. Dirofilariose pulmonar humana: relato de sete casos

    Directory of Open Access Journals (Sweden)

    CAVALLAZZI RODRIGO SILVA

    2002-01-01

    Full Text Available Dirofilariose pulmonar humana é uma doença rara causada pelo parasita Dirofilaria immitis. Apresenta-se usualmente como um nódulo pulmonar solitário que mimetiza câncer de pulmão. Embora considerada uma doença clinicamente benigna, uma biópsia pulmonar excisional é quase sempre necessária para o diagnóstico. Relatam-se as características epidemiológicas, clínicas e radiológicas de sete casos de dirofilariose pulmonar humana em Florianópolis. De sete pacientes relatados, seis tiveram como achado radiológico um nódulo pulmonar e foram submetidos à biópsia pulmonar excisional para o diagnóstico. Em um paciente, a imagem radiológica não estava disponível para revisão e, portanto, não foi descrita no trabalho; o diagnóstico foi estabelecido pela biópsia transbrônquica.

  10. Role of day 4 HCG as an early predictor of success after methotrexate therapy for ectopic pregnancies.

    Science.gov (United States)

    Girija, S; Manjunath, A P; Salahudin, A; Jeyaseelan, L; Gowri, V; Abu-Heija, A; Al Kharusi, L

    2017-08-01

    To validate whether change in serum HCG levels between days 0 and 4 confer any prognostic value during methotrexate therapy and to quantify its change. This is a retrospective study of 48 tubal ectopic pregnancies treated with single dose methotrexate protocol at University Hospital, Muscat, Oman from January 2012 to December 2013. The clinical outcome was analyzed based on the complete resolution of HCG levels or need for additional doses of methotrexate or recourse to surgery. The percentage change in HCG levels between days 0 and 4 (HCG index) of methotrexate were calculated and receiver operator characteristics curve was plotted to identify the best cutoff levels. In order to get a robust 95% confidence interval, bootstrap method using R software was done using 1000 re-sampling. ROC curve and the predictive values were estimated using MEDCALC software. The mean HCG level on day 4 is significantly higher in treatment failure group (4254±4095 IU/L vs. 2109±3646 IU/L, P=0.008). The HCG levels between day 0 and 4 decreased in 42.7% (21/48) of cases and 80.9% of these cases had treatment success. The HCG levels increased in 57.4% (27/48) of cases and 33.3% of these cases had treatment success. (P=0.001). A 10 percent decline in day 4 HCG levels predict the treatment success with sensitivity of 77% and Specificity 81%. The area under the ROC curve was 0.82 (95% CI: 0.67-0.92), (PHCG values on day 4, decrease in HCG level from day 0 to 4 and 10% or more fall in day 4 HCG levels. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Maternal urinary beta-core hCG in chromosomally abnormal pregnancies in the first trimester

    NARCIS (Netherlands)

    Kornman, LH; Morssink, LP; Wortelboer, MJM; Beekhuis, [No Value; DeWolf, BTHM; Pratt, JJ; Mantingh, A

    We evaluated urinary beta-core human chorionic gonadotropin (beta-core hCG) in the detection of fetal Down's syndrome (DS) in the first trimester of pregnancy. Urine was collected prior to performing chorionic villous sampling (CVS) between 10 and 12 completed weeks from the last menstrual period.

  12. Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS

    DEFF Research Database (Denmark)

    Castillo, Juan C; Garcia-Velasco, Juan; Humaidan, Peter

    2012-01-01

    This study aimed to explore the incidence of empty follicle syndrome (EFS) in oocyte donors who had final oocyte maturation triggered with GnRHa and to compare the incidence of EFS in this group of patients with IVF patients who had final oocyte maturation with hCG....

  13. Discovery of a giant HI tail in the galaxy group HCG 44

    CERN Document Server

    Serra, Paolo; Duc, Pierre-Alain; Oosterloo, Tom; McDermid, Richard M; Michel-Dansac, Leo; Emsellem, Eric; Cuillandre, Jean-Charles; Alatalo, Katherine; Blitz, Leo; Bois, Maxime; Bournaud, Frederic; Bureau, Martin; Cappellari, Michele; Crocker, Alison F; Davies, Roger L; Davis, Timothy A; de Zeeuw, P T; Khochfar, Sadegh; Krajnovic, Davor; Kuntschner, Harald; Lablanche, Pierre-Yves; Morganti, Raffaella; Naab, Thorsten; Sarzi, Marc; Scott, Nicholas; Weijmans, Anne-Marie; Young, Lisa M

    2012-01-01

    We report the discovery of a giant HI tail in the intra-group medium of HCG 44 as part of the Atlas3D survey. The tail is ~300 kpc long in projection and contains ~5x10^8 M_sun of HI. We detect no diffuse stellar light at the location of the tail down to ~28.5 mag/arcsec^2 in g band. We speculate that the tail might have formed as gas was stripped from the outer regions of NGC 3187 (a member of HCG 44) by the group tidal field. In this case, a simple model indicates that about 1/3 of the galaxy's HI was stripped during a time interval of <1 Gyr. Alternatively, the tail may be the remnant of an interaction between HCG 44 and NGC 3162, a spiral galaxy now ~650 kpc away from the group. Regardless of the precise formation mechanism, the detected HI tail shows for the first time direct evidence of gas stripping in HCG 44. It also highlights that deep HI observations over a large field are needed to gather a complete census of this kind of events in the local Universe.

  14. Verifying the effectiveness of medical abortion; ultrasound versus hCG testing.

    Science.gov (United States)

    Fiala, Christian; Safar, Peter; Bygdeman, Marc; Gemzell-Danielsson, Kristina

    2003-08-15

    The combination of mifepristone and misoprostol is an established method for termination of pregnancy. However, there is no general agreement about how best to evaluate the treatment outcome. In 217 women with an unwanted pregnancy below 49 days of amenorrhoea, ultrasound examination and serum hCG test were performed before treatment and at follow-up. Treatment was successful in 98.2%. At follow-up their hCG dropped to a mean of 3% (S.D. 3) of initial levels and the endometrium measured a mean of 10 mm (S.D. 4). Interpretation of endometrium was difficult in some cases because of inhomogeneous structure. Using hCG was reliable in 98.5% of successful abortions. For ultrasound the corresponding figure was 89.8% for the cases with a confirmed intrauterine pregnancy before treatment but only 66% if all pregnancies were included. Measuring serum hCG before treatment and at follow-up is more effective than ultrasound to confirm a successful medically induced abortion in early pregnancy.

  15. Pre-evacuation hCG glycoforms in uneventful complete hydatidiform mole and persistent trophoblastic disease.

    NARCIS (Netherlands)

    Thomas, C.M.G.; Kerkmeijer, L.G.W.; Ariaens, H.J.; Steen, R. van der; Massuger, L.F.A.G.; Sweep, F.C.

    2010-01-01

    OBJECTIVE: To investigate whether the glycoform distribution patterns of human chorionic gonadotropin (hCG) obtained by chromatofocusing in pre-evacuation serum are different for patients who will eventually develop into persistent trophoblastic disease in case of complete hydatidiform mole

  16. Maternal urinary beta-core hCG in chromosomally abnormal pregnancies in the first trimester

    NARCIS (Netherlands)

    Kornman, LH; Morssink, LP; Wortelboer, MJM; Beekhuis, [No Value; DeWolf, BTHM; Pratt, JJ; Mantingh, A

    1997-01-01

    We evaluated urinary beta-core human chorionic gonadotropin (beta-core hCG) in the detection of fetal Down's syndrome (DS) in the first trimester of pregnancy. Urine was collected prior to performing chorionic villous sampling (CVS) between 10 and 12 completed weeks from the last menstrual period. I

  17. Predictive value of plasma hCG measured 14 days after Day-2 single embryo transfer

    DEFF Research Database (Denmark)

    Løssl, Kristine; Oldenburg, Anna; Toftager, Mette

    2017-01-01

    INTRODUCTION: Prediction of pregnancy outcome after IVF is important for patients and clinicians. Early plasma hCG (p-hCG) levels are the best known predictor of pregnancy outcome, but no studies has been restricted to single embryo transfer (SET) of Day-2 embryos. The aim of the present study...

  18. Vaginal Fluid hCG Levels for Detecting Premature Rupture of Membranes

    Directory of Open Access Journals (Sweden)

    T. Artimani

    2004-04-01

    Full Text Available The aim of this study was to determine whether there is any different in hCG levels of vaginal fluids from normal pregnant women, women with confirmed PROM and with suspected PROM. After irrigating the posterior vaginal fornix with 3 ml of sterile saline and procuring vaginal washing , we measured hCG levels. Samples were analyzed from 38 normal pregnant women , 31 women with confirmed PROM , 28 women with suspected PROM. The mean of vaginal fluid hCG levels of normal pregnant women were 11.2 (0.00-98.6 mIu/ml. That of women with PROM was 140.2 (0.5 , 390.1 and that of women with suspected PROM was 21.5 (0.0 , 143.9. Sensivity was 80%, specility 83% , positive predictive value 73.7% , negative predictive value 88.1% , using a cut-value 20. It was concluded that the hCG level in vaginal fluid is a marker of PROM during third trimester.

  19. "Follicular HCG endometrium priming for IVF patients experiencing resisting thin endometrium. A proof of concept study"

    DEFF Research Database (Denmark)

    Papanikolaou, E G; Kyrou, D; Zervakakou, G;

    2013-01-01

    A thin endometrium is one of the most difficult problems encountered in assisted reproduction every day practice. Whether a daily dose of 150 IU HCG for 7 days concomitant with estrogen administration in estrogen replacement cycles can increase the endometrial thickness and improve pregnancy outc...

  20. First trimester intact hCG as an early marker of trisomy 21: a promise unrecognised?

    Science.gov (United States)

    Spencer, Kevin; Cowans, Nicholas J; Uldbjerg, Niels; Vereecken, Annie; Tørring, Niels

    2008-12-01

    An initial study of trisomy 21 cases showed that prior to 10 weeks, maternal serum levels of intact hCG in the early first trimester are lower than normal. Here we further study the levels prior to and after 10 weeks of gestation to further establish whether or not the intact hCG is effective as a very early screening marker. Fifty-nine samples from pregnancies with trisomy 21 were identified, 31 were collected between the sixth and ninth weeks of gestation and 28 after the tenth week. A series of 629 gestational age-matched samples collected during the same period formed the control group. Intact hCG was measured by a DELFIA assay. The multiples of the median (MoM) in cases (n = 31) collected prior to 10 weeks were 0.79 (CI 0.62-0.98) at a median gestation of 9.1 weeks. Prior to 9 weeks (n = 14) the median was 0.774 (CI 0.54-1.09) at a median gestation of 8.5 weeks. Modelling the detection rate for a 3 or 5% false-positive rate when screening using intact hCG, free beta-hCG and PAPP-A at 8-10 weeks of gestation indicated that 71 or 77% of cases would be detected. More data are needed to establish a secure MoM for intact hCG in pregnancies prior to 10 weeks, before it could be considered a suitable screening marker. Copyright (c) 2008 John Wiley & Sons, Ltd.

  1. HCG induces β1,4-GalT I expression and promotes embryo implantation.

    Science.gov (United States)

    Chen, Lili; Xie, Yunpeng; Fan, Jianhui; Sui, Linlin; Xu, Yuefei; Zhang, Ningning; Ma, Yanni; Li, Yinghua; Kong, Ying

    2015-01-01

    Embryo implantation is regarded as a critical physiological process for the success of pregnancy. There are so many reports on the research of human chorionic gonadotropin (HCG) in artificial insemination, but the impact of HCG on endometrial receptivity has not been elucidated. Beta1, 4-Galactosyltransferase-I (β1,4-GalT-I) is ubiquitously expresses in human tissues with the exception of the brain. It not only transfers galactose from UDP-galactoside to GlcNAc to form Galβl,4-GlcNAc, but plays crucial role as cell adhesion molecule by recognizing and adhering other extracellular matrix and galactose of cell surface glycoprotein and glycolipid in cancer cells invasion and migration. The process of the embryos implantation is very similar to tumor invasion, so many biological factors participate in the tumor invasion also play a role in embryo implantation. We hypothesize that β1,4-GalT-I may take part in embryo implantation. In this study, we demonstrated that the over expression of β1,4-GalT-I was induced by HCG in RL95-2 cells. Moreover, the expression of some molecules, such as TIMP-1, LN and MMPs could be regulated by engineered expression of β1,4-GalT-I and therefore lead to the significantly alteration of adhesion capability of RL95-2 cells, even result in reduced adhesive ability between JAR cells and RL95-2 cells. Furthermore, our results indicated that HCG can obviously increase the EGFR signaling pathways-dependent molecular expression through β1,4-GalT-I, HCG also improved the adhesive ability between JAR cells and RL95-2 cells (PHCG provides a mechanism to bridge embryo to endometrium through β1,4-GalT.

  2. Routine Β-HCG Monitoring for Single-Dose Methotrexate Treatment in Ectopic Pregnancy.

    Science.gov (United States)

    Dai, Yuxin; Zhang, Guorui; Zhu, Lan; Lang, Jinghe; Liu, Zhufeng

    2017-08-08

    To evaluate an alternative monitoring protocol without D4 β-HCG measurement for predicting the need for a repeated methotrexate (MTX) dose in patients undergoing single-dose MTX therapy for ectopic pregnancy. Single center, Retrospective study (Canadian Task Force classification II-3). University-affiliated hospital. 184 ectopic pregnancy patients who were treated with MTX between January 2009 and December 2016 were included in the study. Single-dose MTX treatment (50mg/m(2)) MEASUREMENTS AND MAIN RESULTS: The patients were treated with repeated doses of MTX every 7 days, if necessary, according to Stovall's protocol or with laparoscopic surgery in cases of tubal rupture. The success of a single-dose of MTX according to the alternative measure was defined as a >50% decrease in the β-HCG level between day (D) 1 and D7 in clinically stable patients. The sensitivity, specificity, false-negative rate, false-positive rate and attributable risk of this new monitoring measure were calculated and compared to the traditional regimen. The new protocol had a sensitivity and specificity of 100% and 88.7%, respectively, for predicting a required second dose in patients whose D1 β-HCG levels were HCG level ≥2000 mIU/mL, both monitoring regimens had the same efficiency. The new monitoring model without the D4 β-HCG measurement may offer both patients and clinicians multiple options to monitor single-dose MTX therapy for selected ectopic pregnancy patients, with a comparable clinical efficiency to Stovall's protocol and less expense and follow-up burden to patients. Copyright © 2017. Published by Elsevier Inc.

  3. Metafísica del alma humana

    OpenAIRE

    Guiu Andreu, Ignacio

    1991-01-01

    Con esta tesis me propongo una comprensión radical del alma humana en términos de ser. Un estudio del alma ut ens, ut habens esse. La composición real de esencia y ser es la clave que nos permite definir metafísicamente a todo ente finito y desentrañar así su estructura última y más profunda. Ahora bien, como la verdad se funda en el ser más que en la esencia, veritas fundatur in esse magis quam in quidditate (In I Sent., d. 19, q. 5, a. 1), la verdad del alma y, en consecuencia, la del hombr...

  4. Ehrliquiosis granulocitotrópica humana

    Directory of Open Access Journals (Sweden)

    José Rafael Rojas-Solano

    2007-04-01

    Full Text Available Las ehrliquiosis humanas son zoonosis emergentes transmitidas por varias especies de garrapatas e infectan gran cantidad de animales silvestres y domésticos. Reportamos el caso de un paciente con un cuadro clínico y hallazgos de laboratorio compatibles con una probable ehrliquiosis granulocitotrópica severa. El paciente se trató con doxicilina y respondió adecuadamente. Fue egresado en buena condición.Human ehrlichiosis are emergent tick-borne zoonoses, affecting many wild and domestic mammals. We report the case of a patient with a clinical picture and laboratory findings compatible with severe granulocytic ehrlichiosis. The patient was treated with doxyciclin and did fine.

  5. Libertad humana y presciencia divina en Boecio

    Directory of Open Access Journals (Sweden)

    Manuel Correia M.

    2002-01-01

    Full Text Available En este artículo, me propongo mostrar que la discusión de Boecio sobre la compatibilidad de la libertad humana y la praescientia divina (De consolatione philosophiae, Libro V es una elaborada doctrina que une elementos neoplatónicos y lógica aristotélica. Según argumento, la discusión está conectada a la preocupación anterior sobre este tema mantenida por los estoicos, y sus principales líneas de desarrollo van a influir en pensadores como Santo Tomás de Aquino, L. Valla y G.W. Leibniz. En lo esencial, la doctrina de Boecio dice que no es la sola razón humana lo que hace al hombre libre, sino su fin, que es Dios como ser eternamente presente a los procesos necesarios y contingentes del universo. Esto está supuesto en sus palabras finales sobre el poder de la oraciónIn this article, I attempt to show that Boethius' discussion on the compatibility between human freedom and praescientia divina (De consolatione philosophiae, Book V is a refined piece of doctrine combining Neoplatonic elements and Aristotelian logic. The discussion, I argue, is connected to the Stoic early concern on the topic and its main lines of development are to be influential in later thinkers as St. Th. Aquinas, L. Valla and G.W. Leibniz. Basically, Boethius' doctrine means that it is not only the human reason by itself what makes the man free, but also the end of reason, i.e., God, who is eternally present to necessary and contingent processes in the universe. This is suggested by his final words on the power of prayer

  6. Epidemiologia da raiva humana na Guanabara

    Directory of Open Access Journals (Sweden)

    Alfredo R. Matta B. da Silva

    1971-08-01

    Full Text Available A raiva humana se mantém como problema de Saúde Pública, especialmente nas áreas urbanas, onde o cão atua como principal reservatório e fonte imediata de infecção. A deficiência de programas de controle de cães vadios, de imunização sistemática e de educação sanitária, contribui para a perpetuação da cadeia epidemiológioa. O presente estudo analisa todos os casos de raiva humana, observados em habitantes do Estado da Guanabara, no período 1965-1969, segundo as variáveis: idade, sexo, côr, variação estacional, período de incubação e de duração da fase clínica, fonte de infecção, local de mordedura e uso de vacina posterior à exposição. Os principais resultados foram: 1. A ravia na Guanabara, parece ser mais comum nos grupos etários mais jovens e nos homens. 2. Não se observou variação estacional. 3. O período de incubação mediano foi de 45 dias e de duração da fase clínica de 3 dias. 4. Ocorreu uma associação entre período de incubação menor e vacinação incompleta.

  7. Carbohydrate composition of the alpha-subunit of human choriogonadotropin (hCG alpha) and the free alpha molecules produced in pregnancy: most free alpha and some combined hCG alpha molecules are fucosylated.

    Science.gov (United States)

    Blithe, D L

    1990-06-01

    The carbohydrate compositions of pregnancy-derived hCG alpha (dissociated from intact hCG) and free alpha-subunit were analyzed using a combination of chemical analysis, lectin affinity chromatography, and glycosidase sensitivity. For direct compositional analysis, parallel samples were hydrolyzed in trifluoroacetic acid and analyzed for sialic acid and neutral sugars without prior derivatization. Separation of the monosaccharides was achieved by HPLC on a Dionex CarboPac column eluted at high pH, and the resolved monosaccharides were quantified by pulsed amperometric detection. The amounts of sugar that were found relative to peptide indicated the presence of two N-linked oligosaccharides per molecule on both hCG alpha and free alpha. Free alpha contained 2.5-fold higher amounts of sialic acid and galactose as well as a higher amount of N-acetylglucosamine than did hCG alpha. Free alpha also contained a 6-fold higher amount of fucose than did hCG alpha (1.2 vs. 0.2 residues of fucose/molecule). Serial fractionation of intact hCG alpha and free alpha molecules by lectin affinity chromatography indicated that virtually all of the hCG alpha-subunits contained at least one Concanavalin-A (Con-A)-binding site, whereas as many as 32% of the free alpha molecules could not bind to Con-A. Chromatography on Lens culinaris (Lch) resulted in 12% binding of hCG alpha and approximately 72% binding of free alpha (80-85% of the Con-A-bound free alpha and 47-48% of the Con-A-nonbound free alpha bound to Lch). Endoglycosidase-H (endo-H) treatment of hCG alpha released a portion of the oligosaccharides. The endo-H-released material appeared to be a monoantennary hybrid based on DEAE-binding properties and carbohydrate composition. In contrast to hCG alpha, free alpha was completely resistant to endo-H treatment. Incubation of endo-H-resistant hCG alpha with glycopeptidase-A resulted in the release of two components, which could be separated into monoantennary and biantennary

  8. Predictive value of serum HCG concentrations in pregnancies achieved after single fresh or vitrified-warmed blastocyst transfer.

    Science.gov (United States)

    Oron, Galia; Shavit, Tal; Esh-Broder, Efrat; Weon-Young, Son; Tulandi, Togas; Holzer, Hananel

    2017-09-01

    Possible differences between serum HCG levels in pregnancies achieved after transfer of a single fresh or a vitrified-warmed blastocyst were evaluated. Out of 1130 single blastocyst transfers resulting in positive HCG results, 789 were single fresh blastocyst transfers and 341 single vitrified-warmed blastocyst transfers. The initial serum HCG levels of 869 clinical intrauterine pregnancies were evaluated, 638 after the transfer of a single fresh blastocysts and 231 after the transfer of a single vitrified-warmed blastocysts. The HCG levels from cycles resulting in a clinical intrauterine pregnancy were significantly higher after the transfer of a single vitrified-warmed blastocyst (383 ± 230 IU/l) versus a fresh transfer (334 ± 192 IU/l; P = 0.01). Threshold values for predicting a clinical pregnancy for a fresh blastocyst were 111 IU/l and for a vitrified-warmed blastocyst 137 IU/l. Our study shows that the overall beta-HCG levels are comparable after the transfer of a fresh or vitrified-warmed blastocyst, suggesting that vitrification most probably does not affect the ability of the embryos to produce beta-HCG. This study further shows that when clinicians counsel patients, they should take into account that higher HCG levels are needed after a vitrified-warmed blastocyst transfer to predict a clinical intrauterine pregnancy. Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  9. Clinical and laboratory issues associated with persistent low-level elevations of hCG in a female of childbearing age.

    Science.gov (United States)

    Bjornson, Loring K; Rangan, Aruna; Fenster, Tamatha B; Magotra, Minoti; Nimaroff, Michael

    2014-03-20

    Persistent low-level elevations of serum concentrations of hCG in a non-pregnant female of childbearing age were investigated by a number of laboratory techniques including heterophile blocking reagents, polyethylene glycol precipitation, serial dilutions and hCG measurements on several different instrument/reagent systems. The results of these studies indicated that this patient had immunoreactive hCG in her serum that was not the intact hCG molecule but primarily the free β-hCG subunit. Differential diagnoses are discussed along with recommendation for continued surveillance of serum hCG concentrations. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. The Risk of Preeclampsia According to High Thyroid Function in Pregnancy Differs by hCG Concentration.

    Science.gov (United States)

    Korevaar, Tim I M; Steegers, Eric A P; Chaker, Layal; Medici, Marco; Jaddoe, Vincent W V; Visser, Theo J; de Rijke, Yolanda B; Peeters, Robin P

    2016-12-01

    During pregnancy, there is an increased demand for thyroid hormone. The pregnancy hormone human chorionic gonadotropin (hCG) is an important physiological stimulator of thyroid function. Already high-normal maternal free T4 concentrations are associated with a higher risk of preeclampsia. The objective of the investigation was to study our hypothesis that hCG concentrations can distinguish a physiological form of high thyroid function from a more pathological form of high thyroid function and that the risk of preeclampsia would differ accordingly. TSH, free T4, hCG, or thyroperoxidase antibody concentrations were determined in pregnant women participating in a population-based prospective cohort study. The study was conducted in the general community. A nonselected sample of 5146 pregnant women participated in the study. There were no interventions. Preeclampsia was measured. Women with high hCG-associated high thyroid function did not have a higher risk of preeclampsia than women with normal thyroid function. In contrast, women with low hCG and high thyroid function had a 3.4- to 11.1-fold higher risk of preeclampsia. These risk estimates were amplified in women with a high body mass index. Women with a low hCG and suppressed TSH (hCG was not associated with preeclampsia, and results remained similar after exclusion of thyroperoxidase antibody-positive women. This study suggests that, in contrast to women with a high hCG associated high thyroid function, women with low hCG and high thyroid function during pregnancy are at a higher risk of developing preeclampsia. The additional measurement of hCG may therefore help to distinguish a more pathological form of high thyroid function and women at a high risk of preeclampsia.

  11. LH and hCG Action on the Same Receptor Results in Quantitatively and Qualitatively Different Intracellular Signalling

    Science.gov (United States)

    Casarini, Livio; Lispi, Monica; Longobardi, Salvatore; Milosa, Fabiola; La Marca, Antonio; Tagliasacchi, Daniela; Pignatti, Elisa; Simoni, Manuela

    2012-01-01

    Human luteinizing hormone (hLH) and chorionic gonadotropin (hCG) act on the same receptor (LHCGR) but it is not known whether they elicit the same cellular and molecular response. This study compares for the first time the activation of cell-signalling pathways and gene expression in response to hLH and hCG. Using recombinant hLH and recombinant hCG we evaluated the kinetics of cAMP production in COS-7 and hGL5 cells permanently expressing LHCGR (COS-7/LHCGR, hGL5/LHCGR), as well as cAMP, ERK1/2, AKT activation and progesterone production in primary human granulosa cells (hGLC). The expression of selected target genes was measured in the presence or absence of ERK- or AKT-pathways inhibitors. In COS-7/LHCGR cells, hCG is 5-fold more potent than hLH (cAMP ED50: 107.1±14.3 pM and 530.0±51.2 pM, respectively). hLH maximal effect was significantly faster (10 minutes by hLH; 1 hour by hCG). In hGLC continuous exposure to equipotent doses of gonadotropins up to 36 hours revealed that intracellular cAMP production is oscillating and significantly higher by hCG versus hLH. Conversely, phospho-ERK1/2 and -AKT activation was more potent and sustained by hLH versus hCG. ERK1/2 and AKT inhibition removed the inhibitory effect on NRG1 (neuregulin) expression by hLH but not by hCG; ERK1/2 inhibition significantly increased hLH- but not hCG-stimulated CYP19A1 (aromatase) expression. We conclude that: i) hCG is more potent on cAMP production, while hLH is more potent on ERK and AKT activation; ii) hGLC respond to equipotent, constant hLH or hCG stimulation with a fluctuating cAMP production and progressive progesterone secretion; and iii) the expression of hLH and hCG target genes partly involves the activation of different pathways depending on the ligand. Therefore, the LHCGR is able to differentiate the activity of hLH and hCG. PMID:23071612

  12. "hCG priming" effect in controlled ovarian stimulation through a long protocol

    Directory of Open Access Journals (Sweden)

    Antsaklis Aris

    2009-08-01

    Full Text Available Abstract Background Recently, it has been demonstrated that, in patients down-regulated by GnRH analogues (GnRHa, a short-term pre-treatment with recombinant LH (rLH, prior to recombinant FSH (rFSH administration, increases the number of small antral follicle prior to FSH stimulation and the yield of normally fertilized embryos. However, no data exist in the literature regarding the potential beneficial effect of "hCG priming" in controlled ovarian hyperstimulation (COH through a long GnRH-a protocol, which binds the same receptor (LH/hCGR, though it is a much more potent compared to LH. The primary aims of this study were to assess the effect of short-term pre-rFSH administration of hCG in women entering an ICSI treatment cycle on follicular development, quality of oocytes and early embryo development. The secondary endpoints were to record the effects on endometrial quality and pregnancy rate. Methods Patients with a history of at least one previous unsuccessful ICSI cycle were randomly assigned into two groups to receive treatment with either a long protocol with rFSH (control group or a long protocol with rFSH and pre-treatment with hCG (hCG group. In particular, in the latter group, a fixed 7 days course of 200 IU/day hCG was administered as soon as pituitary desensitization was confirmed. Results The mean number of oocytes retrieved was not significantly different between the two treatment groups, although the percentage of mature oocytes tended to be higher but not significantly different in hCG-treated patients. The percentage of patients with more than one grade 3 embryos was higher in the pre-treatment group, which also showed a higher pregnancy rate. Conclusion All the above clinical observations, in conjunction with previous data, suggest a point towards a beneficial "hCG priming" effect in controlled ovarian hyperstimulation through a long GnRH-a down-regulation protocol, particularly in patients with previous ART failures.

  13. Gonadotrofina coriônica humana e hormônio liberador de gonadotrofina como indutores da reprodução do jundiá = Human chorionic gonadotropin and gonadotropin-releasing hormone as breeding inducers of jundiá

    Directory of Open Access Journals (Sweden)

    Paulo César Falanghe Carneiro

    2008-07-01

    Full Text Available Este trabalho foi realizado com o objetivo de avaliar parâmetros reprodutivos de machos e fêmeas de jundiá adultos após a aplicação do HCG (gonadotrofina coriônica humana e do GnRHa (hormônio liberador do hormônio gonadotrópico e compará-los àqueles obtidos quando usado o extrato hipofisário da carpa comum. Etapa 1 (Machos - quatro grupos, com oito machos cada, receberam os seguintes tratamentos: M1: sem hormônio; M2: extrato hipofisário 0,5 mg kg-1; M3: HCG 200 UI kg-1; M4: GnRHa+inibidor dopaminergético 0,1 glóbulo(Ovopel® kg-1. Etapa 2 (fêmeas – 36 fêmeas foram divididas em cinco grupos: F1: extrato hipofisário em duas aplicações, 0,5 e 5,0 mg kg-1; F2: HCG em duas aplicações, 200 e 400 UI kg-1; F3: HCG 400 UI kg-1 em doseúnica; F4: HCG 1000 UI kg-1 em dose única; F5: GnRHa+inibidor dopaminergético 1 glóbulo(Ovopel® kg-1. O uso do extrato hipofisário da carpa comum aumentou significativamente o volume de sêmen liberado e estimulou maior quantidade de fêmeas à liberar óvulos. O HCG e o GnRHa não apresentaram resultados positivos no tocante à reprodução induzida do jundiá, nas doses utilizadas neste estudo.In this study we analyzed reproductive parameters of males and females of jundiá induced by HCG (human chorionic gonadotropin and GnRHa (gonadotropin-releasing hormone, and compared the results tothose using carp pituitary extract. Stage 1 (Males - four groups with eight males each received one of the following treatments: M1: without hormone; M2: pituitary extract 0.5 mg kg-1; M3: HCG 200 UI kg-1; M4: GnRHa+dopamine receptor antagonist 0.1 pellet (Ovopel® kg-1. Stage 2 (Females – thirty-six females were separated in 5 groups: F1: pituitary extract in two applications, 0.5 and 5.0 mg kg-1; F2: HCG in two applications, 200 and 400 UI kg-1; F3: HCG 400 UI kg-1 in a single dose; F4: HCG 1000 UI kg-1 in a singledose; F5: GnRHa+dopamine receptor antagonist 1 pellet (Ovopel® kg-1. The pituitary extract

  14. Intrafollicular Endocrine Milieu After Addition of hCG to Recombinant FSH During Controlled Ovarian Stimulation for In Vitro Fertilization

    DEFF Research Database (Denmark)

    Thuesen, L L; Andersen, A Nyboe; Loft, A;

    2014-01-01

    CONTEXT: The role of human chorionic gonadotropin (hCG) supplementation on the intrafollicular steroid milieu has been studied. OBJECTIVE: The objective of the study was to assess the impact on steroid levels in follicular fluids (FFs) after different doses of hCG supplementation to recombinant FSH...... protocol with recombinant FSH 150 IU/d and randomized from stimulation day 1 to supplementation with hCG: D0, 0 IU/d; D50, 50 IU/d; D100, 100 IU/d; and D150, 150 IU/d. MAIN OUTCOME MEASURE: Intrafollicular hormone concentrations in relation to treatment groups, follicular sizes, and embryo quality were...... measured. RESULTS: In large follicles, hCG supplementation induced a nearly 3-fold increase of estradiol (nanomoles per liter) [D0: 1496; D50: 3138; D100: 4338; D150: 4009 (P

  15. Integration of GaAs-based VCSEL array on SiN platform with HCG reflectors for WDM applications

    Science.gov (United States)

    Kumari, Sulakshna; Gustavsson, Johan S.; Wang, Ruijun; Haglund, Emanuel P.; Westbergh, Petter; Sanchez, Dorian; Haglund, Erik; Haglund, Åsa; Bengtsson, Jörgen; Le Thomas, Nicolas; Roelkens, Gunther; Larsson, Anders; Baets, Roel

    2015-02-01

    We present a GaAs-based VCSEL structure, BCB bonded to a Si3N4 waveguide circuit, where one DBR is substituted by a free-standing Si3N4 high-contrast-grating (HCG) reflector realized in the Si3N4 waveguide layer. This design enables solutions for on-chip spectroscopic sensing, and the dense integration of 850-nm WDM data communication transmitters where individual channel wavelengths are set by varying the HCG parameters. RCWA shows that a 300nm-thick Si3N4 HCG with 800nm period and 40% duty cycle reflects strongly (HCG's influence on the VCSEL wavelength, allowing for a 15-nm-wide wavelength setting range with low threshold gain (<1000 cm-1).

  16. Cannonball lung metastases as a presenting feature of ectopic hCG expression

    Directory of Open Access Journals (Sweden)

    Rong-Hsin Yang

    2016-08-01

    Full Text Available Cannonball metastases refer to well-defined spherical nodules scattered over both lungs, being a classical presentation of hematogenous tumor spreading. Striking progression of lung metastases without established primary malignancy can raise a diagnostic challenge. We herein report three cases with cannonball metastases at initial presentation. Two patients ended up having a choriocarcinoma but no awareness of the presence of primary tumors, and the third had abrupt lung metastases of endometrial cancer while she was being asymptomatic. Relentless progression was illustrated by clinical and radiographic changes. Ectopic expression of human chorionic gonadotropin (hCG would seemingly go some way responsible for fulminant cancer spreading associated with poor prognosis in our patients. The goal of this presentation is to raise awareness of ectopic hCG expression in patients presenting with similar astonishing scenarios.

  17. Abnormal hCG levels in a patient with treated stage I seminoma: a diagnostic dilemma.

    LENUS (Irish Health Repository)

    Aherne, Noel J

    2008-01-01

    BACKGROUND: We report the case of a patient with treated Stage Ia seminoma who was found to have an elevated beta human chorionic gonadotrophin (hCG) on routine follow - up. This instigated restaging and could have lead to commencement of chemotherapy. CASE PRESENTATION: The patient was a bodybuilder, and following a negative metastatic work - up, admitted to injecting exogenous beta hCG. This was done to reduce withdrawal symptoms from androgen abuse. The patient remains well eight years post diagnosis. CONCLUSION: This case highlights the need for surgical oncologists to conduct vigilant screening of young male patients with a history of testicular germ cell tumours and who may indulge in steroid abuse.

  18. Abnormal hCG levels in a patient with treated stage I seminoma: a diagnostic dilemma

    Directory of Open Access Journals (Sweden)

    Fitzpatrick David G

    2008-06-01

    Full Text Available Abstract Background We report the case of a patient with treated Stage Ia seminoma who was found to have an elevated beta human chorionic gonadotrophin (hCG on routine follow – up. This instigated restaging and could have lead to commencement of chemotherapy. Case presentation The patient was a bodybuilder, and following a negative metastatic work – up, admitted to injecting exogenous beta hCG. This was done to reduce withdrawal symptoms from androgen abuse. The patient remains well eight years post diagnosis. Conclusion This case highlights the need for surgical oncologists to conduct vigilant screening of young male patients with a history of testicular germ cell tumours and who may indulge in steroid abuse.

  19. Adiaspiromicose pulmonar humana Human pulmonary adiaspiromycosis

    Directory of Open Access Journals (Sweden)

    Lina Gomes dos Santos

    2009-08-01

    Full Text Available A adiaspiromicose é uma doença fúngica sistêmica que acomete usualmente roedores e raramente atinge o homem. É causada pelo fungo Emmonsia crescens e ocorre após a inalação da forma contagiante (conídios. Embora estas formas não se multipliquem nem se disseminem no organismo humano, induzem uma reação inflamatória crônica granulomatosa de padrão miliar que pode levar a falência respiratória e morte. Apresentamos aqui um caso de adiaspiromicose pulmonar humana em paciente imunocompetente que exibia infiltrado intersticial pulmonar difuso ao exame de imagem e fora diagnosticado mediante biópsia pulmonar.Adiaspiromycosis is a systemic fungal disease that usually affects rodents and rarely infects humans. It is caused by the fungus Emmonsia crescens and occurs after inhalation of its contagious form (conidia. Although these forms neither multiply nor spread in the human body, they cause a chronic granulomatous inflammatory reaction of miliary pattern, which may lead to respiratory failure and death. In this study we present a case of human pulmonary adiaspiromycosis in an immunocompetent patient that showed a diffuse pulmonary interstitial infiltrate diagnosed by pulmonary biopsy.

  20. DE NUEVO SOBRE LA DIGNIDAD HUMANA

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    Antonio-Carlos Pereira-Menaut

    2014-01-01

    Full Text Available De la Segunda Guerra Mundial en adelante, la dignidad humana es recogida en muchas constituciones, declaraciones de derechos y tratados internacionales. Esto no significa que sea un concepto nuevo, pues su significado puede rastrearse sin dificultad en la tradición judeo-cristiana y, mucho más tarde, en la influyente comprensión kantiana; y tampoco significa que no haya tenido relación con el Derecho antes de 1945. Por otro lado, las nuevas tendencias filosóficas y antropológicas así como la politización del hombre, junto con los avances de la técnica, explican su presencia cada vez mayor en el Derecho. Sin embargo, la inclusión de la dignidad en los textos jurídicos no es capaz de agotar su significado —ni aunque los textos sean los constitucionales—, y el hecho de que los jueces la aleguen no significa que la empleen realmente como criterio para su decisión, como puede verse al estudiar algunas sentencias relevantes.

  1. Is maternal serum total hCG a marker of trisomy 21 in the first trimester of pregnancy?

    Science.gov (United States)

    Spencer, K; Berry, E; Crossley, J A; Aitken, D A; Nicolaides, K H

    2000-04-01

    In a study of 130 first trimester cases of trisomy 21 and 959 controls we have shown that the median MoM for alpha-fetoprotein (AFP) is lower (0.82) and that for total human chorionic gonadotrophin (hCG) is higher (1.31) than in the control group. For AFP 15.3% of cases were below the 5th centile and for total hCG 19. 8% were above the 95th centile. The median shift observed for AFP and total hCG is poorer than that for pregnancy associated plasma protein-A (PAPP-A) or free beta-hCG and together with maternal age, AFP and total hCG could only be expected to detect 40% of cases. In combination with PAPP-A, total hCG would identify 52% of cases, somewhat less than the 67% observed with free beta-hCG and PAPP-A. However, we have demonstrated for total hCG a significant temporal change in median MoM with gestational age. Before 70 days the median MoM was less than 0.5, between 70 and 83 days this increased to 1.13, and between 84 and 97 days this increased to 1.52. This median shift has significant implications for interpreting previous studies and even more significant implications for detection rates. When population parameters specific to the gestational age in question are used, detection rates with total hCG and PAPP-A increase from 47% at 70-83 days to 60% at 84-97 days. This observation explains much of the confusion around total hCG in the first trimester and shows the importance of selecting analyte pairs and population parameters appropriate to the time in gestation when screening is performed. Copyright 2000 John Wiley & Sons, Ltd.

  2. VizieR Online Data Catalog: CO in HCG galaxies with enhanced warm H2 (Lisenfeld+,

    Science.gov (United States)

    Lisenfeld, U.; Appleton, P. N.; Cluver, M. E.; Guillard, P.; Alatalo, K.; Ogle, P.

    2014-07-01

    The files name hcgxxco10offx_offy.fits are the fits files spectra in Fig. A1 (CO(1-0) spectra). The files name hcgxxco21offx_offy.fits are the fits files of the spectra in Fig. A2 (CO(2-1) spectra). Here, xx stands for the HCG number of the galaxy and offx, offy are the offsets with respect to the central pointing. (3 data files).

  3. Addition of low dose hCG to rFSh benefits older women during ovarian stimulation for IVF

    Directory of Open Access Journals (Sweden)

    Gomaa Hala

    2012-08-01

    Full Text Available Abstract Background To compare the outcome of IVF cycles in women receiving controlled ovarian stimulation with recFSH or recFSH plus low dose hCG. Methods A retrospective case control study, performed at a private practice affiliated with an academic institute. Patients were infertile women who were treated with IVF/ICSI and controlled ovarian stimulation in a long GnRH agonist protocol using either low dose hCG in addition to recFSH [N = 88] or recFSH alone [N = 99]. Primary outcomes were mean FSH dose, number of mature eggs, number of fertilized eggs, and serum levels of estradiol. Secondary outcomes were endometrial thickness, cycle cancellations and pregnancy rates. Results A significant increase in number of mature and fertilized eggs was observed in women over 40 years of age using low dose hCG in addition to recFSH. The estradiol level was significantly higher on the day of hCG administration and the serum level of FSH on cycle day 7 and on the day of hCG administration were lower. Conclusion Addition of low dose hCG to recFSH compared with recFSH alone significantly modified cycle characteristics in patients >/= 40 years and could be of potential benefit for IVF cycles in older infertile women.

  4. Persistent low levels of serum hCG due to heterophilic mouse antibodies: an unrecognized pitfall in the diagnosis of trophoblastic disease.

    Science.gov (United States)

    González Aguilera, B; Syrios, P; Gadisseur, R; Luyckx, F; Cavalier, E; Beckers, A; Valdes-Socin, H

    2016-06-01

    Phantom hCG refers to persistent mild elevations of hCG, leading physicians to unnecessary treatments whereas neither a true hCG nor a trophoblastic disease is present. We report the case of a 23-year-old woman with persistent low levels of serum hCG detected one month after miscarriage. As choriocarcinoma was suspected, a chemotherapy trial of methotrexate was prescribed, without any hCG reduction. Subsequently, laparoscopy ruled out a trophoblastic residue and the patient was referred to the Endocrine Unit for further investigations. While low levels of hCG were still detected in serum, no hCG was detected in the urine. In addition, when serum was processed in a HBT tube for revealing heterophilic antibodies, hCG was no longer detected. Such finding indicated the presence of phantom hCG due to heterophilic mouse antibodies interaction. This case raises the need of clinico-biological discussion to avoid inappropriate therapeutic decisions. Based on this case experience and after review of the literature, we suggest that current gynecological protocols for the diagnosis and treatment of trophoblastic disease should consider the inclusion of urinary hCG and/or a test for serum heterophilic antibodies when appropriate.

  5. Influence of multiple injections of human chorionic gonadotropin (hCG) on urine and serum endogenous steroids concentrations.

    Science.gov (United States)

    Strahm, Emmanuel; Marques-Vidal, Pedro; Pralong, François; Dvorak, Jiri; Saugy, Martial; Baume, Norbert

    2011-12-10

    Since it is established that human chorionic gonadotropin (hCG) affects testosterone production and release in the human body, the use of this hormone as a performance enhancing drug has been prohibited by the World Anti-Doping Agency. Nowadays, the only validated biomarker of a hCG doping is its direct quantification in urine. However, this specific parameter is subjected to large inter-individual variability and its determination is directly dependent on the reliability of hCG immunoassays used. In order to counteract these weaknesses, new biomarkers need to be evidenced. To address this issue, a pilot clinical study was performed on 10 volunteers submitted to 3 subsequent hCG injections. Blood and urine samples were collected during two weeks in order to follow the physiological effects on related compounds such as the steroid profile or hormones involved in the hypothalamo-pituitary axis. The hCG pharmacokinetic observed in all subjects was, as expected, prone to important inter-individual variations. Using ROC plots, level of testosterone and testosterone on luteinizing hormone ratio in both blood and urine were found to be the most relevant biomarker of a hCG abuse, regardless of inter-individual variations. In conclusion, this study showed the crucial importance of reliable quantification methods to assess low differences in hormonal patterns. In regard to these results and to anti-doping requirements and constraints, blood together with urine matrix should be included in the anti-doping testing program. Together with a longitudinal follow-up approach it could constitute a new strategy to detect a hCG abuse, applicable to further forms of steroid or other forbidden drug manipulation.

  6. Hepatic ethoxy-, methoxy- and pentoxyresorufin O-dealkylase activities in Landrace and Duroc pigs stimulated with HCG.

    Science.gov (United States)

    Zamaratskaia, G; Zlabek, V; Ropstad, E; Tajet, H; Andresen, Ø

    2010-12-01

    The effect of human chorionic gonadotropin (hCG) stimulation on the activities of ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD) and pentoxyresorufin O-depentylase (PROD) was studied in intact male pigs of purebred Landrace and Duroc breeds. Pigs were divided into four groups: two control groups of each breed, without hCG stimulation (n = 20 for each breed), and two experimental groups (n = 18 for each breed), with hCG stimulation (Pregnyl(®); N.V. Organon, Oss, The Netherlands, 30 IU/kg live weight). Pigs were slaughtered 3 days after hCG stimulation and enzyme activities were measured in hepatic microsomes using two approaches. First, only one substrate concentration was used for the analysis of each enzyme activity. We found that EROD activity was suppressed by hCG-stimulation in Landrace (p = 0.004), but not Duroc pigs (p > 0.05). Generally, EROD activity was higher in Duroc pigs compared with Landrace (p = 0.017). Methoxyresorufin O-demethylase and PROD activities did not differ between groups (p > 0.05). To further characterize EROD, MROD and PROD, enzyme kinetic studies were performed. V(max) values for EROD and MROD in both breeds were lower after hCG stimulation (p Landrace and p Landrace and Duroc pigs being higher in Duroc pigs (p < 0.05). We concluded that both hCG stimulation and breed differences may be important in the regulation of EROD and MROD activities. This study provides the first data on the effect of hCG stimulation and thus high testicular steroids, on EROD, MROD and PROD activities. Further studies are needed to investigate individual CYP450 enzymes and their regulation in porcine tissues.

  7. Mid-trimester maternal serum HCG and alpha fetal protein levels: clinical significance and prediction of adverse pregnancy outcome.

    Science.gov (United States)

    Androutsopoulos, Georgios; Gkogkos, Panagiotis; Decavalas, Georgios

    2013-01-01

    Maternal serum human Chorionic Gonadotropin (hCG) and Alpha Fetal Protein (AFP) were originally introduced to detect trisomy 21 and neural tube defects. However, in the absence of aneuploidy or neural tube defects, mid-trimester maternal serum hCG and/or maternal serum AFP associated with adverse pregnancy outcomes. Pregnancies with unexplained mid-trimester elevation in maternal serum hCG and/or maternal serum AFP, are at increased risk for pregnancy complications resulting from placental insufficiency. Mid-trimester maternal serum hCG>2.5 MoM associated with an increased risk for pregnancy complications including: late fetal loss, gestational hypertension, preeclampsia, intrauterine growth restriction (IUGR), preterm delivery and intrauterine fetal death(IUFD). Mid-trimester maternal serum AFP levels >2.5 MoM are thought to reflect a defect in placentation and associated with an increased risk for pregnancy complications including: late fetal loss, gestational hypertension, preeclampsia, IUGR, preterm delivery and IUFD. Combined mid-trimester elevation in maternal serum hCG and AFP levels suggest a more complex type of placental pathology. They have stronger association with pregnancy complications including: late fetal loss, gestational hypertension, preeclampsia, IUGR, preterm delivery and IUFD. Mid-trimester maternal serum hCG or AFP levels alone cannot detect all pregnant women with increased risk to develop pregnancy complications. Multiparameter testing of placental function in mid-trimester (maternal serum hCG and AFP screening, uterine artery Doppler and placental morphology) may allow us to identify women with increased risk to develop severe placental insufficiency and pregnancy complications. However, future prospective studies are needed to confirm the prognostic significance of multiparameter testing of placental function in mid-trimester.

  8. An HCG-rich microenvironment contributes to ovarian cancer cell differentiation into endothelioid cells in a three-dimensional culture system.

    Science.gov (United States)

    Su, Min; Fan, Chao; Gao, Sainan; Shen, Aiguo; Wang, Xiaoying; Zhang, Yuquan

    2015-11-01

    We investigated the expression of human chorionic gonadotropin (HCG) and its effects on vasculogenic mimicry (VM) formation in ovarian cancer cells under normoxic and hypoxic conditions in three-dimensional matrices preconditioned by an endothelial-trophoblast cell co-culture system. The co-culture model was established using human umbilical vein endothelial cells (HUVECs) and HTR-8 trophoblast cells in a three-dimensional culture system. The co-cultured cells were removed with NH4OH, and ovarian cancer cells were implanted into the preconditioned matrix. VM was identified morphologically and by detecting vascular markers expressed by cancer cells. The specificity of the effects of exogenous HCG in the microenvironment was assessed by inhibition with a neutralizing anti-HCG antibody. HCG siRNA was used to knock down endogenous HCG expression in OVCAR-3 ovarian cancer cells. HTR-8 cells 'fingerprinted' HUVECs to form capillary-like tube structures in co-cultures. In the preconditioned HCG-rich microenvironment, the number of vessel-like network structures formed by HCG receptor-positive OVCAR-3 cells and the expression levels of CD31, VEGF and factor VIII were significantly increased. The preconditioned HCG-rich microenvironment significantly increased the expression of hypoxia inducible factor-1α (HIF‑1α) and VM formation in OVCAR-3 cells under hypoxic conditions. Treatment with a neutralizing anti-HCG antibody but not HCG siRNA significantly inhibited the formation of vessel-like network structures. HCG in the microenvironment contributes to OVCAR-3 differentiation into endothelioid cells in three-dimensional matrices preconditioned with an endothelial-trophoblast cell co-culture system. HCG may synergistically enhance hypoxia-induced vascular markers and HIF-1α expression. These findings would provide perspectives on new therapeutic targets for ovarian cancer.

  9. Human chorionic gonadotropin (hCG) concentrations during the late first trimester are associated with fetal growth in a fetal sex-specific manner.

    Science.gov (United States)

    Barjaktarovic, Mirjana; Korevaar, Tim I M; Jaddoe, Vincent W V; de Rijke, Yolanda B; Visser, Theo J; Peeters, Robin P; Steegers, Eric A P

    2017-02-01

    Human chorionic gonadotropin (hCG) is a pregnancy-specific hormone that regulates placental development. hCG concentrations vary widely throughout gestation and differ based on fetal sex. Abnormal hCG concentrations are associated with adverse pregnancy outcomes including fetal growth restriction. We studied the association of hCG concentrations with fetal growth and birth weight. In addition, we investigated effect modification by gestational age of hCG measurement and fetal sex. Total serum hCG (median 14.4 weeks, 95 % range 10.1-26.2), estimated fetal weight (measured by ultrasound during 18-25th weeks and >25th weeks) and birth weight were measured in 7987 mother-child pairs from the Generation R cohort and used to establish fetal growth. Small for gestational age (SGA) was defined as a standardized birth weight lower than the 10th percentile of the study population. There was a non-linear association of hCG with birth weight (P = 0.009). However, only low hCG concentrations measured during the late first trimester (11th and 12th week) were associated with birth weight and SGA. Low hCG concentrations measured in the late first trimester were also associated with decreased fetal growth (P = 0.0002). This was the case for both male and female fetuses. In contrast, high hCG concentrations during the late first trimester were associated with increased fetal growth amongst female, but not male fetuses. Low hCG in the late first trimester is associated with lower birth weight due to a decrease in fetal growth. Fetal sex differences exist in the association of hCG concentrations with fetal growth.

  10. Serum Human Chorionic Gonadotropin (β- hCG) Clearance Curves in Women with Successfully Expectantly Managed Tubal Ectopic Pregnancies: A Retrospective Cohort Study.

    Science.gov (United States)

    Helmy, Samir; Mavrelos, Dimitrios; Sawyer, Elinor; Ben-Nagi, Jara; Koch, Marianne; Day, Andrea; Jurkovic, Davor

    2015-01-01

    To establish clearance curves for serum β -hCG in women with successfully expectantly managed tubal ectopic pregnancies. Retrospective cohort study. Non- viable tubal ectopic pregnancy was diagnosed on transvaginal ultrasound. If initial serum β hCG was less than 5000 IU/L and patients were asymptomatic, expectant management was offered. Patients underwent serial β hCG measurements until serum β hCG was less than 20 IU/l, or the urine pregnancy test was negative. Early Pregnancy and Gynaecology Assessment Unit, Kings College Hospital, London (December 1998 to July 2006). We included 161 women with diagnosed non-viable tubal ectopic pregnancy who underwent successful expectant management. Serum β hCG level. Mean initial serum β- hCG was 488 IU/L (41 - 4883) and median serum β hCG clearance time was 19 days (5 - 82). The average half-life of β hCG clearance was 82.5 hours (±SD 50.2) in patients with steadily declining serum β- hCG levels compared to 106.7 hours (±SD 72.0) in patients with primarily plateauing β-hCG levels in the declining phase. However, these differences were not significant (p>0.05). We identified a median follow-up of 19 days until serum β hCG clearance in women with tubal ectopic pregnancy and successful expectant management. Although non- significant, women with initially plateauing serum β hCG showed a longer follow-up time until clearance compared to women with steadily declining β hCG levels. This information may serve as a guideline enabling clinicians to predict the length of follow-up for women with tubal ectopic pregnancy and expectant management.

  11. Teoria organizacional para la gerencia humana como factor de desarrollo a escala humana

    Directory of Open Access Journals (Sweden)

    Gregoria Polo de Lobatón

    2014-01-01

    Full Text Available Hoy, se debate en los países subdesarrollados y hasta en desarrollo caso América Latina el estancamiento económico rodeado de un mar de pobreza y exclusión social, en contrario, los paísesdesarrollados a partir de la crisis de 1929 muestran su crecimiento a partir de modelos de desarrollo económico como sustento teórico del pensamiento administrativo captado para las prácticas gerenciales; resultó útil identificar los aportes de la teoría del desarrollo como fundamentación de las teorías organizacionales y su incidencia en las prácticas gerenciales como factor de desarrollo. Metodológicamente la investigación se orientó en el enfoque cualitativo para el análisis fenomenológico de los datos encontrados en revisiones documentales. Los resultados determinaron que las prácticas gerenciales se fundamentan en teorías organizacionales clásicas y contemporáneas centradas en principios de eficiencia y productividad. A partir de las teorías contemporáneas un dinamismo con enfoques sociales y ambientales, su fundamento la escuela humana con los pensadores: Weber, Elton Mayo, reformistas y otros pensadores, que tenidas en cuenta para las prácticas gerenciales centradas en la suficiencia manifiestan interés por el acercamiento al desarrollo a escala humana.Palabras clave: Teorías organizacionales; paradigma de Gerencia Humana; Desarrollo a escala humana.Organizational theory for human management as a development factor to human scale AbstractToday, there are discussions in underdeveloped countries and even in developing ones, Latin American case, the economic halt surrounded by a sea of poverty and social exclusion, in contrast, developed countries starting from the crisis of 1929 show their growth from economic development models as a theoretical backup of the management thinking captured for management practices; proved useful to identify the contributions of development theory as the foundation of organizational theories and

  12. TRANSEXUALIDADE E DIGNIDADE DA PESSOA HUMANA

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    Edwirges Elaine Rodrigues

    2015-10-01

    Full Text Available Este artigo resume-se a uma investigação sobre a transsexualidade ou disforia de gênero, em que o indivíduo não se identifica com o sexo que lhe foi imposto, mas sim, com o  gênero oposto ao seu. Os indivíduos transexuais enfrentam inúmeros preconceitos e dificuldades ao longo de suas vidas, podendo-se afirmar que para alcançar sua completude, o transexual necessita reconhecer-se como titular do sexo oposto em todos os sentidos, médico (adequação do sexo biológico ao sexo psicológico, social (inclusão social deste indivíduo, para que seja aceito pela sociedade e jurídico (perante a lei. No Brasil, não existe legislação específica a respeito da transsexualidade, assim, a regulamentação da cirurgia de transgenitalização é responsabilidade do Conselho Federal de Medicina, e após o árduo procedimento de transgenitalização, o transexual poderá obter a retificação do seu nome e sexo no registro civil, através de requerimento judicial. De maneira inovadora, alguns Tribunais, de acordo com o princípio da dignidade humana, têm concedido tais modificações antes mesmo da cirurgia de redesignação sexual, entretanto, este entendimento não está pacificado, o que acarreta grande injustiça e sofrimento a estas pessoas. Assim, busca-se demonstrar de maneira cristalina, a necessidade de legislação específica,  a fim de facilitar o acesso dos transexuais, tanto à cirurgia de transgenitalização, quanto às retificações de nome e sexo no assento civil. 

  13. Hidatidosis humana en el Perú

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    Luis Guerra Montero

    2015-06-01

    Full Text Available El objetivo de este trabajo ha sido conocer el estado de la hidatidosis humana, por la gran incidencia que presenta en nuestro país, principalmente en la región central andina. La recopilación de datos fue a partir de la revisión de fuentes primarias sobre epidemiología, el ciclo vital del parásito y del manejo del paciente afecto de Hidatidosis. Algunos hallazgos permiten afirmar que la hidatidosis es una enfermedad producida por el estado larval del cestodo Echinococcus del género Granulosus, de alta prevalencia en nuestro país y más en la región central andina, esto se debe principalmente a la costumbre de convivir con perros y ganado ovino así como también a la falta de educación y concientización de la población. Los estudios serológicos como Elisa IgG y Wester Blot por su mayor sensibilidad y especificidad son las pruebas de primera línea para confirmar el diagnóstico. Dependiendo del tamaño, las características del quiste hidatídico y su localización se decide el tratamiento. La hidatidosis es una enfermedad producida por el cestodo Echinococcus Granulosus de alta prevalencia en el Perú y más aún en la región central andina (Cerro de Pasco, Junín, Huancavelica, tiene un lento crecimiento dentro de los órganos humanos pudiendo ser asintomáticos hasta la edad adulta, los órganos más afectados son el hígado y el pulmón donde son diagnosticados por sus antecedentes epidemiológicos, clínica sugestiva (dolor abdominal, vómica estudios de imagen principalmente ecografía abdominal, radiografía de tórax y exámenes de laboratorio como el Elisa IgG y Wester Blot.

  14. Taxa de gestação em cabras Alpinas e Saanen tratadas com hCG no terceiro dia após o estro Pregnancy rate and progesterone concentration of Alpine and Saanen goats treated with hCG the third day after estrus

    Directory of Open Access Journals (Sweden)

    C.P. Prosperi

    2006-04-01

    Full Text Available Avaliou-se o efeito da aplicação da gonadotrofina coriônica humana (hCG sobre a taxa e duração da gestação e sobre a concentração plasmática de progesterona (P4 em cabras lactantes das raças Alpina (83 e Saanen (60, na estação de acasalamento induzida pelo programa de fotoperíodo artificial. Os animais foram distribuídos em dois tratamentos após a cobrição; as cabras do tratamento 1 (T1 controle receberam solução salina via intramuscular (1ml, e as do tratamento 2 (T2 receberam 250UI do hCG, no terceiro dia no pós-estro. As taxas de gestação, detectadas por exame ultra-sonográfico, realizado no 35º após a cobrição, para as cabras das raças Alpina e Saanen controle e tratadas, foram de 80,4; 70,3; 72,7; 81,5%, respectivamente, não diferindo entre os tratamentos e entre as raças (P>0,05. A taxa média de gestação foi 77,2 e 75,0% para os animais controle e tratados, respectivamente. A duração da gestação não foi influenciada pelos tratamentos (P>0,05. As amostras de sangue para análise da concentração plasmática de progesterona (P4 foram coletadas de cinco cabras Alpina por tratamento, no dia do estro (dia 0 e aos 3, 8, 15, 21, 42 e 60 dias após o estro. Não houve diferença na concentração plasmática média de P4 entre os tratamentos (P>0,05, sendo de 5,84ng/ml para T1 e 5,76ng/ml para T2. Observou-se diferença em relação aos dias de coleta (PThe experimental objective was to evaluate the effect of human chorionic gonadotropin (hCG administration on pregnancy rate and gestation length and on serum concentration of progesterone (P4 in Alpine (83 and Saanen (60 dairy goats induced by artificial photoperiod to enter the breeding season. Animals were randomly allocated to two treatments following estrus: in treatment 1 (T1 goats received 1ml saline solution and in treatment 2 (T2 animals received 250IU of hCG in 1ml saline intramuscularly during the third day after estrus. Pregnancy rates detected by

  15. Induction of ovulation in quarter horse mares through the use of deslorelin acetate and human chorionic gonadotrophin (hCG

    Directory of Open Access Journals (Sweden)

    Tatiana Figueiredo

    2011-06-01

    Full Text Available The aim this study was to compare two protocols of induction for ovulation by desloreline acetate and hCG in Quarter Horse mares. The choice of the animals was based on the observations by the estrus, by rectal palpation of the ovaries and by ultrassonography of the follicular dynamics. After estrus detection and follicle control, the measurement of the follicles and the classification of uterus were carried out. The animals that had dominant follicle (diameter more than 35 mm and swollen uterus were used. In these conditions, the mares received hCG or desloreline acetate. Once ovulation occurred, the artificial insemination was carried. Two groups were performed: G1 (20 animals received 1.5 mg desloreline acetate and G2 (20 animals received 1700 IU of hCG. Following 6h intervals, the control follicular was performed by ultrasonography. The follicular average diameter was 42.6 cm for the groups and set up a score of 0 to 3 of uterine edema displayed by the device as well as the time of ovulation. In conclusion, the desloreline acetate showed better performance than hCG, because the ovulation was induced in less time (nine hours than hCG (p<0.05.The pregnancy rate was 80 and 75 %, respectively in G1 and G2.

  16. Rat epididymal epithelial cells and 17beta-estradiol synthesis under hCG stimulation in vitro.

    Directory of Open Access Journals (Sweden)

    Mariola Marchlewicz

    2007-10-01

    Full Text Available Epithelial cells of human and animal epididymis display features of steroidogenic cells. Rat epididymal epithelial cells in vitro produce androgens which are converted to 17beta-estradiol, and released into the medium. The regulation of the epididymal steroidogenesis is not fully understood but it could be expected that it remains under LH influence. In previous study we observed that the morphology of rat epididymal epithelial cells in vitro was affected by hCG and the increase of amount of lipid droplets, glycogen and PAS-positive substances was observed. The present studies show the organelles which take part in synthesis of steroids in rat epididymal epithelial cells in vitro and the effect of hCG on E2 synthesis. The cells were cultured in the medium with/without DHT and without DHT in supplementation with hCG. After hCG stimulation the amount of an active mitochondria were increased when compared to the amount of mitochondria in the epididymal epithelial cells cultured without DHT. Ultrastructure of the cells was similar to the cells cultured with DHT, while the cytoplasm of the cells cultured without DHT was disorganized. The synthesis of 17beta-estradiol was stimulated by hCG, that exerted its effect through LH/hCG receptors, localized in the epididymal epithelial cells.

  17. High oestradiol concentration after ovarian stimulation is associated with lower maternal serum beta-HCG concentration and neonatal birth weight.

    Science.gov (United States)

    Liu, Suying; Kuang, Yanping; Wu, Yu; Feng, Yun; Lyu, Qifeng; Wang, Li; Sun, Yijuan; Sun, Xiaoxi

    2017-08-01

    In this retrospective study, the relationship between maternal serum oestradiol and progesterone levels after fresh embryo transfer or frozen embryo transfer (FET), and serum beta-HCG levels in early pregnancy and neonatal birth weight was examined. Included for analysis were 5643 conceived singletons: 2610 after FET and 3033 after fresh embryo transfer. Outcome measures included maternal serum oestradiol, progesterone, beta-HCG levels during the peri-implantation period, birth weight and small-for-gestational-age (SGA). Results at 4, 5 and 6 weeks' gestation were as follows: serum oestradiol and progesterone levels were significantly higher in women who underwent fresh embryo transfer compared with FET (all P HCG levels were significantly lower than in women who underwent FET (P HCG levels were negatively correlated with serum oestradiol; and birth weight was negatively correlated with serum oestradiol. Incidence of SGA in fresh embryo transfer was increased significantly compared with FET (P HCG in early pregnancy, lower birth weight and higher incidence of SGA. Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  18. Deep Imaging of the HCG 95 Field. I. Ultra-diffuse Galaxies

    Science.gov (United States)

    Shi, Dong Dong; Zheng, Xian Zhong; Zhao, Hai Bin; Pan, Zhi Zheng; Li, Bin; Zou, Hu; Zhou, Xu; Guo, KeXin; An, Fang Xia; Li, Yu Bin

    2017-09-01

    We present a detection of 89 candidates of ultra-diffuse galaxies (UDGs) in a 4.9 degree2 field centered on the Hickson Compact Group 95 (HCG 95) using deep g- and r-band images taken with the Chinese Near Object Survey Telescope. This field contains one rich galaxy cluster (Abell 2588 at z = 0.199) and two poor clusters (Pegasus I at z = 0.013 and Pegasus II at z = 0.040). The 89 candidates are likely associated with the two poor clusters, giving about 50–60 true UDGs with a half-light radius {r}{{e}}> 1.5 {kpc} and a central surface brightness μ (g,0)> 24.0 mag arcsec‑2. Deep z\\prime -band images are available for 84 of the 89 galaxies from the Dark Energy Camera Legacy Survey (DECaLS), confirming that these galaxies have an extremely low central surface brightness. Moreover, our UDG candidates are spread over a wide range in g ‑ r color, and ∼26% are as blue as normal star-forming galaxies, which is suggestive of young UDGs that are still in formation. Interestingly, we find that one UDG linked with HCG 95 is a gas-rich galaxy with H i mass 1.1× {10}9 M ⊙ detected by the Very Large Array, and has a stellar mass of {M}\\star ∼ 1.8× {10}8 M ⊙. This indicates that UDGs at least partially overlap with the population of nearly dark galaxies found in deep H i surveys. Our results show that the high abundance of blue UDGs in the HCG 95 field is favored by the environment of poor galaxy clusters residing in H i-rich large-scale structures.

  19. Gonadotrofina coriônica humana e hormônio liberador de gonadotrofina como indutores da reprodução do jundiá - DOI: 10.4025/actascianimsci.v30i3.929 Human chorionic gonadotropin and gonadotropin-releasing hormone as breeding inducers of jundiá - DOI: 10.4025/actascianimsci.v30i3.929

    Directory of Open Access Journals (Sweden)

    Paulo César Falanghe Carneiro

    2008-11-01

    Full Text Available Este trabalho foi realizado com o objetivo de avaliar parâmetros reprodutivos de machos e fêmeas de jundiá adultos após a aplicação do HCG (gonadotrofina coriônica humana e do GnRHa (hormônio liberador do hormônio gonadotrópico e compará-los àqueles obtidos quando usado o extrato hipofisário da carpa comum. Etapa 1 (Machos - quatro grupos, com oito machos cada, receberam os seguintes tratamentos: M1: sem hormônio; M2: extrato hipofisário 0,5 mg kg-1; M3: HCG 200 UI kg-1; M4: GnRHa+inibidor dopaminergético 0,1 glóbulo(Ovopel® kg-1. Etapa 2 (fêmeas – 36 fêmeas foram divididas em cinco grupos: F1: extrato hipofisário em duas aplicações, 0,5 e 5,0 mg kg-1; F2: HCG em duas aplicações, 200 e 400 UI kg-1; F3: HCG 400 UI kg-1 em dose única; F4: HCG 1000 UI kg-1 em dose única; F5: GnRHa+inibidor dopaminergético 1 glóbulo(Ovopel® kg-1. O uso do extrato hipofisário da carpa comum aumentou significativamente o volume de sêmen liberado e estimulou maior quantidade de fêmeas à liberar óvulos. O HCG e o GnRHa não apresentaram resultados positivos no tocante à reprodução induzida do jundiá, nas doses utilizadas neste estudo.Hormone acquisition represents high cost, justifying the importance of studies searching for better results on inducing fish reproduction in laboratory conditions. This study analyzed the efficiency of HCG and GnRHa for gonad maturation and gamete production in jundiá, and compare the results to those using pituitary extract. Stage 1 (Males - Four groups with eight males each received the following treatments: M1: Without hormone; M2: Pituitary extract 0.5 mg/kg; M3: HCG 200 UI/kg; M4: GnRHa+dopamine receptor antagonist 0.1 pellet/kg. Stage 2 (Females – Thirty six females were separated in 5 groups: F1: Pituitary extract in two applications, 0.5 and 5.0 mg/kg; F2: HCG in two applications, 200 and 400 UI/kg; F3: HCG 400 UI/kg in a single dose; F4: HCG 1000 UI/kg in a single dose; F5: Gn

  20. DIGNIDAD HUMANA, DIVERSIDAD CULTURAL Y CALIDAD DE VIDA

    OpenAIRE

    Édgar Antonio López López

    2009-01-01

    En este artículo, se propone la calidad de vida como una expresión concreta de la dignidad humana que permite superar el relativismo en la discusión bioética sobre la diversidad cultural y los límites de una concepción universalista de los derechos humanos. Después de hacer referencia al proceso mediante el cual las nociones cristianas de dignidad humana y de derecho natural fueron secularizadas, se hace examen de la conservadora crítica culturalista de Lee Kwan yew y de la crítica comunitari...

  1. EFFECT OF PMSG FOLLOWED BY HCG ON ESTRUS SYNCHRONIZATION IN WEANED SOWS

    OpenAIRE

    S. Naskar; Kadirvel, G; M.H. Khan; A. Lamare

    2012-01-01

    A total of 60 crossbred sows (Hampshire X Khasi Local) were selected a week after weaning and divided into two groups (30 in each). The sows in group-I were injected with 800 IU of PMSG followed by 400 IU of HCG 56 hours after PMSG. In Group-II served as untreated / control. Natural service was given to all estrus sows after 96 hours of hormonal treatment. It was noticed that 90 % of sow exhibited all the sign of estrus after 96 hours and 75 % of sows were sexually receptive to boar. The aver...

  2. VizieR Online Data Catalog: HCG and RSCG compact group galaxies with WISE (Zucker+, 2016)

    Science.gov (United States)

    Zucker, C.; Walker, L. M.; Johnson, K.; Gallagher, S.; Alatalo, K.; Tzanavaris, P.

    2016-07-01

    For this study, we draw our sample from groups in the HCG catalog (Hickson 1982, VII/213) and the Redshift Survey Compact Group catalog (RSCG; Barton et al. 1996AJ....112..871B). We utilize new ALLWISE coadds from Lang (unWISE; 2014AJ....147..108L), which preserve the native resolution of the raw frames (~6.1", 6.4", 6.5" and 12.0" for bands W1, W2, W3, and W4). (1 data file).

  3. The Expression and Significance of CD44v6 and HCG in Endometrial Cancer%CD44v6和 HCG 在子宫内膜癌中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    柴光兰; 张燕华; 张铭艳

    2012-01-01

      目的检测 HCG 和 CD44v6在正常子宫内膜、子宫内膜不典型增生和不同分化程度子宫内膜癌组织中表达的不同,探讨 HCG 和 CD44v6与子宫内膜癌发生、发展的关系.方法采用免疫组织化学 SP 法,检测正常子宫内膜30例、子宫内膜不典型增生30例、不同分化程度子宫内膜癌38例中 HCG 和 CD44v6的表达.结果 CD44v6在正常子宫内膜组织、子宫内膜不典型增生、子宫内膜癌组织中的阳性表达分别为28.57%,58.33%,88.89%,三者比较差异有显著性;HCG 阳性表达分别为35.71%,66.67%,91.67%,三者比较差异亦有显著性(P <0.05).结论 CD44v6和 HCG 在正常子宫内膜、子宫内膜不典型增生及子宫内膜癌组织中的表达不同,可作为良性增生和子宫内膜癌鉴别的参考指标.%  Objective To detect the expression of CD44v6 and human chorionic gonadotrophin (HCG) in normal endometrium, endometrial atypical hyperplasia and endometrial carcinoma and investigate the development and prognosis of HCG and CD 44v6 in endome-tria1 carcinoma.Methods Expression of HCG and CD44v6 was assayed by immunohistochemistry in 30 cases with normal endometrium ,30 cases with endometrial atypical hyperplasia and 38 cases with endometrial carcinoma .Gold immunoelectron microscopy technique was used to detect espression of HCG and CD44v6 protein in endometrial carcinoma .Results The expression quantity of CD44v6 in normal endometri-um,endometrial atypical hyperplasia and cancer tissues were 28.57%,58.33%,88.89% respectively(P <0.05).The expression quantity of HCG were 35.71%,66.67%,91.67% respectively(P <0.05).Conclusion The immunohistochemical analysis show a trend toward in -creased HCG and CD44v6 expression in endometrial carcinoma and endometrial atypical hyperplasia compared to normal endometrium .HCG and CD44v6 may play an important role in tumor production of endometrial carcinoma .

  4. The Role of Serum Beta hCG in Early Diagnosis and Management Strategy of Ectopic Pregnancy.

    Science.gov (United States)

    Surampudi, Kameswari; Gundabattula, Sirisha Rao

    2016-07-01

    The presentation of Ectopic Pregnancy (EP) can be highly variable and serum Beta hCG estimation plays an important role in early diagnosis. Aim of the study was to determine the trends of hCG levels in EP and to explore the role of hCG in decisions related to management and follow-up of EPs. A retrospective study of women who had EPs from January 2006 to December 2012 at an advanced tertiary care centre in southern India was carried out. These women had undergone treatment based on the hospital protocol. The study identified 337 women with EP. Thirty one surgically confirmed cases were diagnosed below the discriminatory zone of 1500 mIU/ml. Among women who had Beta hCG estimations 48 hours apart, plateauing was observed in 22.5% while decrease >15% was noted in 26.8%. Almost half (47.9%) of the cases had an increase >15% and a few (2.8%) demonstrated an initial fall followed by a rise in titres. In 23.9% of these women, there was a rise >53% similar to intrauterine pregnancy. The average pre-treatment Beta hCG was 429.8, 3866.2 and 12961.5 mIU/ml for those who received expectant, medical and direct surgical treatment respectively. 43 women with relative contraindications received medical management and 39 were lost to follow-up after medical and expectant management. Excluding them, the success rate of these two modalities was 76.6% and 85.0% respectively. No single level of Beta hCG is diagnostic of EP and serial levels can demonstrate atypical trends in some cases. Hence, interpretation of these results should be done in conjunction with clinical and sonographic findings to arrive at a correct diagnosis.

  5. Effect of kisspeptin-10, LH and hCG on serum testosterone concentrations in stallions, donkeys and mules.

    Science.gov (United States)

    Akhtar, Rana Waseem; Shah, Syed Aftab Hussain; Qureshi, Irfan Zia

    2017-07-21

    This study was conducted to determine the response of serum testosterone (T) in male equines (stallions, donkeys and mules) after administering intravenous doses of kisspeptin-10 (KP-10), human chorionic gonadotropin (hCG) and luteinizing hormone (LH) and saline as a control. The animals were divided into four groups of three each: Group I, 3 ml of 0.95% saline; Group II, 50 μg KP-10; Group III, 2500 IU hCG and group IV, 400 μg LH. The administration of KP-10 and hCG to stallions resulted in a significant increase in serum T concentration at 240 min; whereas it was significantly higher at 30, 60, 120, and 240 min with LH treatment as compared to pre-dose concentrations. Both KP-10 and hCG significantly elevated the T concentrations in donkeys at 120 and 240 min, respectively; whereas it was significantly higher at 60, 120, and 240 min with LH treatment as compared to pre-dose concentration. Both KP-10 and LH elevated T in donkeys at 240 min as compared to the control and hCG concentrations. After 120 and 240 min, T concentrations in mules were higher (p hCG and LH as compared to the control. In conclusion, the administration of KP-10, hCG and LH elevate the serum T concentration in normal male equines. It is suggested that KP-10 may be useful in situations where an increase in T is desired. Further work is required to determine the effect of KP-10 on T in male equids with reproductive abnormalities before it can be used in clinical situations. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Intragroup diffuse light in compact groups of galaxies II. HCG 15, 35 and 51

    CERN Document Server

    Da Rocha, C; de Oliveira, C Mendes

    2008-01-01

    This continuing study of intragroup light in compact groups of galaxies aims to establish new constraints to models of formation and evolution of galaxy groups, specially of compact groups, which are a key part in the evolution of larger structures, such as clusters. In this paper we present three additional groups (HCG 15, 35 and 51) using deep wide field $B$ and $R$ band images observed with the LAICA camera at the 3.5m telescope at the Calar Alto observatory (CAHA). This instrument provides us with very stable flatfielding, a mandatory condition for reliably measuring intragroup diffuse light. The images were analyzed with the OV\\_WAV package, a wavelet technique that allows us to uncover the intragroup component in an unprecedented way. We have detected that 19, 15 and 26% of the total light of HCG 15, 35 and 51, respectively, is in the diffuse component, with colours that are compatible with old stellar populations and with mean surface brightness that can be as low as $28.4 {\\rm B mag arcsec^{-2}}$. Dyn...

  7. Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice.

    Science.gov (United States)

    Ratner, Laura D; Stevens, Guillermina; Bonaventura, Maria Marta; Lux-Lantos, Victoria A; Poutanen, Matti; Calandra, Ricardo S; Huhtaniemi, Ilpo T; Rulli, Susana B

    2016-07-01

    The metabolic syndrome is a growing epidemic; it increases the risk for diabetes, cardiovascular disease, fatty liver, and several cancers. Several reports have indicated a link between hormonal imbalances and insulin resistance or obesity. Transgenic (TG) female mice overexpressing the human chorionic gonadotropin β-subunit (hCGβ+ mice) exhibit constitutively elevated levels of hCG, increased production of testosterone, progesterone and prolactin, and obesity. The objective of this study was to investigate the influence of hCG hypersecretion on possible alterations in the glucose and lipid metabolism of adult TG females. We evaluated fasting serum insulin, glucose, and triglyceride levels in adult hCGβ+ females and conducted intraperitoneal glucose and insulin tolerance tests at different ages. TG female mice showed hyperinsulinemia, hypertriglyceridemia, and dyslipidemia, as well as glucose intolerance and insulin resistance at 6 months of age. A 1-week treatment with the dopamine agonist cabergoline applied on 5-week-old hCGβ+ mice, which corrected hyperprolactinemia, hyperandrogenism, and hyperprogesteronemia, effectively prevented the metabolic alterations. These data indicate a key role of the hyperprolactinemia-induced gonadal dysfunction in the metabolic disturbances of hCGβ+ female mice. The findings prompt further studies on the involvement of gonadotropins and prolactin on metabolic disorders and might pave the way for the development of new therapeutic strategies. © 2016 Society for Endocrinology.

  8. Testosterona e gonadotrofina coriônica humana estimulam a esteroidogênese em células da granulosa de folículo pré-ovulatório de égua? Do testosterone and human chorionic gonadotropin stimulate steroidogenesis in granulosa cells of preovulatory follicle in mare?

    Directory of Open Access Journals (Sweden)

    M.C. Caldas-Bussiere

    2005-02-01

    Full Text Available Avaliou-se o papel da gonadotrofina coriônica humana (hCG e da testosterona na produção de progesterona (P4 e 17beta -estradiol (E2 pelas células da granulosa cultivadas in vitro de folículo antral de égua. Os tratamentos usados foram: 1- controle (nenhum hormônio adicionado, 2- 1UI hCG (0,3mig/ml e 3- 10UI hCG (3,0mig/ml. O tratamento com hCG foi realizado na presença ou não de testosterona (144ng/ml. O meio foi coletado e substituído com 0,25, 3, 6, 12, 24 e 144h de cultivo. As concentrações de P4 e E2 foram mensuradas por radioimunoensaio. Não se observou diferença entre os tratamentos 1 e 3 quanto à produção de P4 e E2; o tratamento 1 resultou em aumento da concentração de progesterona após 24h de cultura (PThe role of the human chorionic gonadotropin (hCG and testosterone was evaluated in the progesterone (P4 and estradiol-17beta (E2 production by granulosa cells of antral follicles from mare cultivated in vitro. The treatment (groups with gonadotropin consisted of: 1- control (no added hormone; 2- 1 IU hCG (0.3mg/ml and 3- 10 IU hCG (3.0mg/ml. The treatment with hCG was carried out in the presence or not of testosterone (144ng/ml. The culture medium was collected and replaced at 0.25, 3, 6, 12, 24 and 144h of culture. The concentrations of P4 and E2 were measured by radioimunoassay. Analyses of variance were used for P4 and E2, and mean of the factors were compared by the Tukey test at 5% of probability. No difference was observed between 1 and 2 groups. Treatment with 1 IU of hCG increased progesterone concentration after 24h of culture (P<0.01, only in the presence of testosterone. The concentration of estradiol increased in the presence of testosterone, reaching maximum concentration with 6h of culture (P<0.01, and reduced gradually until the observed concentration at 0.25h of culture. The addition of hCG had no effect in the synthesis of this steroid. The testosterone modulates the action of the luteinizing hormone

  9. Illusory Liberalism in "Atlas de Geografía Humana"

    Science.gov (United States)

    Ryan, Lorraine

    2014-01-01

    "Atlas de Geografía Humana" constitutes a critique of the much vaunted notion of a progressive Spain that has rectified the gender inequalities of the Francoist era, as one of the highly educated and successful protagonists, Fran, unwittingly adopts her mother's alignment with patriarchal norms. This novel elucidates the incompatibility…

  10. Fenomenología y esencia procesual humana

    OpenAIRE

    Fernández Beites, Pilar

    2008-01-01

    Esta ponencia ofrece el esbozo de una posible “ontología fenomenológica de la persona”. El punto de partida es la aceptación del reto existencialista que exige contar con el carácter procesual o dinámico de la vida humana. Pero lo que se defien

  11. Capital humano y capacidad humana Human capital and human capacity

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    Sen Amartya Kumar

    1998-12-01

    Full Text Available En este articulo se examinan las relaciones y diferencias entre el concepto de 'capital humano' y el concepto de 'capacidad humana'. El concepto de capital humano es mas limitado puesto que solo concibe las cualidades humanas en su relación con el crecimiento económico mientras que el concepto de capacidades da énfasis a la expansión de libertad humana para vivir el tipo de vida que la gente considera valedera. Cuando se adopta esa visión mas amplia, el proceso de desarrollo no puede verse simplemente como un incremento del PIB sino como la expansión de la capacidad humana para llevar una vida mas libre y mas digna.In this article the relationships and the differences between the concept of 'human capital' and the concept of 'human capability' are examined. The concept of human capital is more limited since it only conceives human qualities in relation to economic growth, whereas the concept of capabili ties puts emphasis on the expansion of human freedom to live the kind of life that people judge valuable. Whenthis broader vision is adopted, the process of development cannot be seen as simply an increase in the GNP, but rather as the expansion of the human capability to live a more free and worthy life.

  12. Pulsatile GnRH Is Superior to hCG in Therapeutic Efficacy in Adolescent Boys With Hypogonadotropic Hypogonadodism.

    Science.gov (United States)

    Gong, Chunxiu; Liu, Ying; Qin, Miao; Wu, Di; Wang, Xiaoling

    2015-07-01

    We investigated the efficacy and safety of two different treatments that have not been evaluated in peripuberty boys with hypogonadotropic hypogonadism (HH). The objective of the study was to assess the effectiveness and safety of GnRH or human chorionic gonadotropin (hCG) treatment in adolescent boys with HH. Twelve patients received 8-10 μg of GnRH, sc injected every 90 minutes using a pump. Another 22 patients received hCG, injected im as follows: for the first 3 months, 1000 IU of hCG was injected two times per week and then once every other day for the next 3 months. The dose of hCG was increased to 2000 IU after a 6-month treatment and the above cycle was repeated for another 6 months. All patients were treated for 12-14 months and followed up every 3 months. Thirty-five participants were chosen from Beijing Children's Hospital from 2008 to 2014. Twenty-three patients with Kallmann syndrome and 12 with normosmic idiopathic hypogonadotropic hypogonadism. The age ranged from 10 to 16 years. Twelve patients were treated with pulsatile pump GnRH (group 1), and 22 patients were treated with im hCG (group 2). One patient was treated successively with hCG and GnRH, which was removed in data analysis. Testicular volume was measured by an orchidometer. The levels of T, LH, and FSH serum were measured with a chemiluminesent immunoassay. Bone age was measured by x-ray. Patients treated with GnRH showed larger testes than those treated with hCG. Patients in both groups showed a significantly increased length of penis and T levels. But the difference of the two groups was not statistically significant. There was no significant difference in side effects in both groups. Boys with HH may be effectively treated with GnRH. We suggested that GnRH exhibits higher efficacy in treating adolescent boys with HH than hCG.

  13. Bio-equivalent doses of recombinant HCG and recombinant LH during ovarian stimulation result in similar oestradiol output

    DEFF Research Database (Denmark)

    Alsbjerg, Birgit; Elbaek, Helle Olesen; Laursen, Rita Jakubcionyte

    2017-01-01

    and HCG bind to the same receptor, significant molecular, structural and functional differences exist, inducing differences in bioactivity. This randomized controlled study compared the effect of recombinant FSH stimulation combined with daily either micro-dose recombinant HCG or recombinant LH...... supplementation in a 1:1 bioactivity ratio from day 1 of stimulation in a long gonadotrophin releasing hormone agonist down regulation protocol. A total of 100 patients from a public clinic completed the study. The primary end-point was the oestradiol level on the day of ovulation trigger and the median...

  14. The molecular relationship between antigenic domains and epitopes on hCG.

    Science.gov (United States)

    Berger, Peter; Lapthorn, Adrian J

    2016-08-01

    Antigenic domains are defined to contain a limited number of neighboring epitopes recognized by antibodies (Abs) but their molecular relationship remains rather elusive. We thoroughly analyzed the antigenic surface of the important pregnancy and tumor marker human chorionic gonadotropin (hCG), a cystine knot (ck) growth factor, and set antigenic domains and epitopes in molecular relationships to each other. Antigenic domains on hCG, its free hCGα and hCGβ subunits are dependent on appropriate inherent molecular features such as molecular accessibility and protrusion indices that determine bulging structures accessible to Abs. The banana-shaped intact hCG comprises ∼7500Å(2) of antigenic surface with minimally five antigenic domains that encompass a continuum of overlapping non-linear composite epitopes, not taking into account the C-terminal peptide extension of hCGβ (hCGβCTP). Epitopes within an antigenic domain are defined by specific Abs, that bury nearly 1000Å(2) of surface accessible area on the antigen and recognize a few up to 15 amino acid (aa) residues, whereby between 2 and 5 of these provide the essential binding energy. Variability in Ab binding modes to the contact aa residues are responsible for the variation in affinity and intra- and inter-species specificity, e.g. cross-reactions with luteinizing hormone (LH). Each genetically distinct fragment antigen binding (Fab) defines its own epitope. Consequently, recognition of the same epitope by different Abs is only possible in cases of genetically identical sequences of its binding sites. Due to combinatorial V(D)J gene segment variability of heavy and light chains, Abs defining numerous epitopes within an antigenic domain can be generated by different individuals and species. Far more than hundred Abs against the immuno-dominant antigenic domains of either subunit at both ends of the hCG-molecule, the tips of peptide loops one and three (Ł1+3) protruding from the central ck, encompassing h

  15. Concomitant use of FSH and low-dose recombinant hCG during the late follicular phase versus conventional controlled ovarian stimulation for intracytoplasmic sperm injection cycles.

    Science.gov (United States)

    Iaconelli, Carla Andrade Rebello; Setti, Amanda Souza; Braga, Daniela Paes Almeida Ferreira; Maldonado, Luiz Guilherme Louzada; Iaconelli, Assumpto; Borges, Edson; Aoki, Tsutomu

    2017-03-22

    The objective of this study was to investigate the effects of low-dose hCG supplementation on ICSI outcomes and controlled ovarian stimulation (COS) cost. Three hundred and thirty patients undergoing ICSI were split into groups according to the COS protocol: (i) control group (n = 178), including patients undergoing conventional COS treatment; and (ii) low-dose hCG group (n = 152), including patients undergoing COS with low-dose hCG supplementation. Lower mean total doses of FSH administered and higher mean oestradiol level and mature oocyte rates were observed in the low-dose hCG group. A significantly higher fertilization rate, high-quality embryo rate and blastocyst formation rate were observed in the low-dose hCG group as compared to the control group. The miscarriage rate was significantly higher in the control group compared to the low-dose hCG group. A significantly lower incidence of OHSS was observed in the low-dose hCG group. There was also a significantly lower gonadotropin cost in the low-dose hCG group as compared to the control group ($1235.0 ± 239.0×$1763.0 ± 405.3, p hCG and FSH results in a lower abortion rate and increased number of mature oocytes retrieved, as well as improved oocyte quality, embryo quality and blastocyst formation and reduced FSH requirements.

  16. Abnormally elevated serum hCG in a patient with end-stage renal disease seeking abortion: to be expected or a cause for concern? A case report.

    Science.gov (United States)

    Thompson, Benjamin W; Zerden, Matthew L; Morse, Jessica E

    2015-07-01

    A patient with end-stage renal disease on hemodialysis was referred to our abortion clinic with a concern for molar pregnancy. By 12 weeks, her human chorionic gonadotropin (hCG) level was over 500,000. A review of the literature demonstrates that elevated hCG should be expected in this population and should not alter care.

  17. Condi(aÇão Humana e Liberdade

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    Joelma Lúcia Vieira Pires

    2015-12-01

    Full Text Available RESUMO:O objeto de estudo deste artigo é a condição humana. Qual a possibilidade de existência da condição humana fundamentada na liberdade? O objetivo é relacionar esfera pública, política, liberdade e condição humana. A elaboração teórica considerou obras de Etienne de La Boétie, Hannah Arendt, Cornelius Castoriadis, entre outros. Na atualidade, ocorre a supressão da condição humana, pois a esfera pública tem a ingerência da esfera privada, predominando a razão instrumental e a lógica do mercado, e o homem é afastado da vida política. Por isso, a nossa ação política pela liberdade é fundamental para a problematização do processo de banalização do mal e da servidão voluntária. A coragem é uma virtude indispensável à ação política, é necessária para nos libertarmos da dominação e do servilismo da vida privada e conquistarmos a vida política. A centralidade da ação política do homem é a sua condição de ser atuante para a reafirmação da esfera pública, do mundo da pluralidade, humano e comum. Todavia, a condição humana fundamentada na liberdade implica a superação da atividade e do pensamento pragmáticos e fragmentários da vida cotidiana e a constituição da praxis na dimensão humano-genérica consciente.

  18. The Alternative Epac/cAMP Pathway and the MAPK Pathway Mediate hCG Induction of Leptin in Placental Cells

    Science.gov (United States)

    Maymó, Julieta Lorena; Pérez Pérez, Antonio; Maskin, Bernardo; Dueñas, José Luis; Calvo, Juan Carlos; Sánchez Margalet, Víctor; Varone, Cecilia Laura

    2012-01-01

    Pleiotropic effects of leptin have been identified in reproduction and pregnancy, particularly in the placenta, where it works as an autocrine hormone. In this work, we demonstrated that human chorionic gonadotropin (hCG) added to JEG-3 cell line or to placental explants induces endogenous leptin expression. We also found that hCG increased cAMP intracellular levels in BeWo cells in a dose-dependent manner, stimulated cAMP response element (CRE) activity and the cotransfection with an expression plasmid of a dominant negative mutant of CREB caused a significant inhibition of hCG stimulation of leptin promoter activity. These results demonstrate that hCG indeed activates cAMP/PKA pathway, and that this pathway is involved in leptin expression. Nevertheless, we found leptin induction by hCG is dependent on cAMP levels. Treatment with (Bu)2cAMP in combination with low and non stimulatory hCG concentrations led to an increase in leptin expression, whereas stimulatory concentrations showed the opposite effect. We found that specific PKA inhibition by H89 caused a significant increase of hCG leptin induction, suggesting that probably high cAMP levels might inhibit hCG effect. It was found that hCG enhancement of leptin mRNA expression involved the MAPK pathway. In this work, we demonstrated that hCG leptin induction through the MAPK signaling pathway is inhibited by PKA. We observed that ERK1/2 phosphorylation increased when hCG treatment was combined with H89. In view of these results, the involvement of the alternative cAMP/Epac signaling pathway was studied. We observed that a cAMP analogue that specifically activates Epac (CPT-OMe) stimulated leptin expression by hCG. In addition, the overexpression of Epac and Rap1 proteins increased leptin promoter activity and enhanced hCG. In conclusion, we provide evidence suggesting that hCG induction of leptin gene expression in placenta is mediated not only by activation of the MAPK signaling pathway but also by the

  19. The Association Between LH Serum Levels at the time of hCG Injection and Clinical Pregnancy during IVF

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    Budi Wiweko

    2015-12-01

    Full Text Available Some studies showed that recombinant follicle stimulating hormone (r-FSH administration without LH supplementation has a good success rate on in vitro fertilization (IVF. However, LH role in IVF has been controversial. This study was conducted to evaluate the association between serum LH levels at the time of hCG injection and clinical pregnancy during IVF. This retrospective study included 136 patients underwent long protocol IVF from January 2005 to December 2009 in Yasmin Clinic, Cipto Mangunkusumo Hospital, Jakarta. The controlled ovarian hyper-stimulation protocol used in this study was gonadotropin-releasing hormone (GnRH agonist and r-FSH.  Serum LH level was measured on the day of hCG administration and the outcome evaluated was the clinical pregnancy following IVF cycles. There were 32 IVF cycles resulted in pregnancy out of 136 cycles (23.5%. There was significant difference between serum LH levels on the day of hCG administration and clinical pregnancy outcome (p=0.036. LH serum level cut-off value of ≥1.050 IU/l was the best value to predict pregnancy outcome with 62.5% sensitivity, 59.4% specificity, 83.3% positive predictive value, and 32.76% negative predictive value. It was concluded that there was an association between serum LH levels at the time of hCG injection and clinical pregnancy during IVF. Keywords: IVF cycles, LH levels serum, hCG administration   Hubungan Kadar LH saat Penyuntikan hCG dengan Kejadian Kehamilan pada Fertilisasi In vitro Abstrak Pemberian follicles stimulating hormone rekombinan (r-FSH tanpa suplementasi LH memiliki tingkat keberhasilan fertilisasi in vitro (FIV yang baik namun, peran LH pada FIV masih kontroversial. Tujuan penelitian ini adalah untuk mengevaluasi hubungan antara kadar serum LH pada hari penyuntikan hCG dengan kehamilan klinis selama FIV. Penelitian retrospektif ini melibatkan 136 perempuan yang menjalani FIV siklus pertama dengan protokol panjang mulai bulan Januari 2005 sampai

  20. 125I-labelled human chorionic gonadotrophin (hCG) as an elimination marker in the evaluation of hCG decline during chemotherapy in patients with testicular cancer

    DEFF Research Database (Denmark)

    Christensen, T B; Engbaek, F; Marqversen, J

    1999-01-01

    The rate of reduction in the concentration of serum human chorionic gonadotrophin (hCG) following chemotherapy for germ cell tumours may follow a complex pattern, with longer apparent half-life during later stages of chemotherapy, even in patients treated successfully. The commonly used half-life...

  1. Early hCG addition to rFSH for ovarian stimulation in IVF provides better results and the cDNA copies of the hCG receptor may be an indicator of successful stimulation

    Directory of Open Access Journals (Sweden)

    Paraskevis Dimitris

    2009-10-01

    Full Text Available Abstract A simple, safe and cost-effective treatment protocol in ovarian stimulation is of great importance in IVF practice, especially in the case of previous unsuccessful attempts. hCG has been used as a substitute of LH because of the degree of homology between the two hormones. The main aim of this prospective randomized study was to determine, for the first time, whether low dose hCG added to rFSH for ovarian stimulation could produce better results compared to the addition of rLH in women entering IVF-ET, especially in those women that had previous IVF failures. An additional aim was to find an indicator that would allow us to follow-up ovarian stimulation and, possibly, modify it in order to achieve a better IVF outcome; and that indicator may be the cDNA copies of the LH/hCG receptor. Group A patients (n = 58 were administered hCG and Group B rLH (n = 56 in addition to rFSH in the first days of ovarian stimulation. The number of follicles and oocytes and, most importantly, implantation and pregnancy rates were shown to be statistically significantly higher in the hCG group. This study has also determined, for the first time to our best knowledge, m-RNA for LH/hCG receptors in the lymphocytes of peripheral blood 40 h before ovum pick-up. cDNA levels of the hCG receptor after ovarian stimulation were significantly higher among women receiving hCG compared to those receiving LH. In addition, higher levels were encountered among women with pregnancy compared to those without, although this was not statistically significant due to the small number of pregnancies. It seems that hCG permits a highly effective and more stable occupancy of rLH/hCG receptors and gives more follicles and more oocytes. The determination of cDNA copies could be, in the future, a marker during ovulation induction protocols and of course a predictor for the outcome of ART in the special subgroup of patients with previous failures.

  2. Effect of Repeated Administration of hCG on Ovarian Response in PMSG-superovulated Ouled Djellal Ewes (Algeria

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    Lamraoui, R.

    2014-01-01

    Full Text Available The objective of this study was to evaluate the effect of repeated administration of hCG on ovarian response in PMSG-superovulated ewes. Intravaginal pessaries containing 40 mg fluorogestone acetate (FGA were inserted in all ewes (n=9 and remained in situ for 14 days. Two days prior to pessary removal, all ewes were treated with 1000 IU of PMSG. On the day of sponge removal (day 0, the females were randomly assigned to 2 treatments. The first group (n=3 did not receive any hCG, while the second group (n=6 treated inter-muscular with hCG (500 IU during days 0-2. On day 8, laparotomy was performed to assess numbers of corpora lutea (CL and anovulatory follicles (AF. Blood samples were collected for analysis of serum progesterone (P4 using radioimmunoassay (RIA method. The results obtained for first and second group was in number of CL (6.33±1.15 and 10.50±5.54, number of AF (2 ±3.46 and 4.16±5.70, then the levels of P4 (5.75± 4.45 and 13.22±6.80 ng/ml, respectively. These results indicate that the repeated administration of hCG post-sponge removal increases number of CL and improves luteal function in ewes after PMSG-superovulatory treatment.

  3. Dynamics of the development of multiple follicles by early versus late hCG administration in ART program.

    Science.gov (United States)

    Falagario, Maddalena; Trerotoli, Paolo; Chincoli, Annarosa; Cobuzzi, Isabella; Vacca, Margherita P; Falagario, Doriana; Nardelli, Claudia; Depalo, Raffaella

    2017-02-01

    To evaluate, in patients stimulated with recombinant FSH and GnRH antagonists, whether triggering the final maturation of oocytes affects IVF outcomes. Five hundred and six IVF procedures were divided into three groups according to the timing of hCG administration: when at least 2 follicles reached the diameter of 17 mm, at least 2 follicles reached 18 mm and at least 2 follicles reached 20 mm. The main outcome was the number of mature oocyte that was the dependent variable of a multivariate model whose independents were, age, AFC, hCG timing, E2 levels at hCG day, number of follicles in different categories of dimension. Secondary endpoints were to compare fertilization, implantation and pregnancy rates in a multilevel multivariate model whose covariates were age, BMI, AFC, embryo quality and cause of infertility. Timing did not result a statistically significant factor influencing the number of oocytes collected, which was influenced by age, AFC, number of follicles between 12.1 and 15.9 mm and E2 levels. Implantation rate and pregnancy rate appear to be affected only by embryo quality. The number of oocytes collected and the probability of pregnancy are not associated with the time of hCG administration.

  4. Development of a recombinant hCG-specific single chain immunotoxin cytotoxic to hCG expressing cancer cells.

    Science.gov (United States)

    Nand, Kripa N; Gupta, Jagdish C; Panda, A K; Jain, S K

    2015-02-01

    A large number of cancers express human chorionic gonadotropin (hCG) or its subunits ectopically. Patients harboring such cancers have poor prognosis and adverse survival. PiPP is a monoclonal antibody of high affinity and specificity for hCGβ/hCG. Work was carried out to develop a PiPP based recombinant immunotoxin for the immunotherapy of hCG expressing cancers. Recombinant PiPP antibody was constructed in scFv format in which gene encoding the VH and VL domains were joined through a linker. This scFv gene was fused to the gene expressing Pseudomonas exotoxin (PE38), and cloned in a Escherichia coli based expression vector under the control of strong bacteriophage T7 promoter. Immunotoxin conjugating scFv(PiPP) and PE38, was expressed in E. coli as recombinant protein. Recombinant PiPP immunotoxin was purified from the bacterial cell lysate and tested for binding and killing of hCGβ expressing lymphoma, T-lymphoblastic leukemia and lung carcinoma cells in vitro. Immunotoxin showed nearly 90% killing on the cells. This is the first ever report on recombinant immunotoxin for binding and cytotoxicity to hCG expressing cancer cells, and thus can be a potential candidate for the immunotherapy of hCG expressing cells. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Value of serum β-HCG, P, CA125, and color Doppler ultrasound in early diagnosis of ectopic pregnancy

    Institute of Scientific and Technical Information of China (English)

    Yan-Li Liu

    2016-01-01

    Objective:To explore the clinical value of serum β-HCG, P, CA125, and color Doppler ultrasound in the early diagnosis of ectopic pregnancy (EP). Methods:A total of 50 patients with EP who were admitted in our hospital from September, 2014 to September, 2015 were included in the study and served as the observation group, while 50 normal pregnant women were served as the control group. A volume of 5 mL of fasting elbow venous blood the day on admission in the two groups was extracted, and then was centrifuged for serum. The chemiluminescence immunoassay was used to detect the levels of serum β-HCG, P, and CA125. After 48h,β-HCG level was detected again. The vaginal color Doppler diasonograph was used to detect the changes of RI and PSV. The blood supply of LH was observed. Results:The levels of serumβ-HCG, P, and CA125 in the observation group were significantly lower than those in the control group (P<0.05). When β-HCG<2 000 IU/L, after 48 h, β-HCG level was doubled in 3 cases (6.0%) in the observation group, while in 49 cases (98.0%) in the control group, and the differences between the two groups were not statistically significant (P<0.05). RI in the observation group was significantly higher than that in the control group, while PSV was significantly lower than that in the control group (P<0.05). Blood supply in the observation group was in a half ring shape, accounting for 58.0%;in the control group was in a ring shape, accounting for 70.0%, and the difference was statistically significant (P<0.05). Conclusions:Determination of the levels of serumβ-HCG, P, and CA125 in the pregnant women, in combined with the vaginal color Doppler ultrasound detection of RI and PSV, can contribute to distinguish the normal intrauterine pregnancy with EP and prevent the misdiagnosis, which can provide an accurate reference value for the early diagnosis and timely treatment of EP, and can be used as an ideal method for the diagnosis of EP.

  6. EFFECT OF PMSG FOLLOWED BY HCG ON ESTRUS SYNCHRONIZATION IN WEANED SOWS

    Directory of Open Access Journals (Sweden)

    S. Naskar

    2012-07-01

    Full Text Available A total of 60 crossbred sows (Hampshire X Khasi Local were selected a week after weaning and divided into two groups (30 in each. The sows in group-I were injected with 800 IU of PMSG followed by 400 IU of HCG 56 hours after PMSG. In Group-II served as untreated / control. Natural service was given to all estrus sows after 96 hours of hormonal treatment. It was noticed that 90 % of sow exhibited all the sign of estrus after 96 hours and 75 % of sows were sexually receptive to boar. The average interval between treatments to onset of estrus was 87.74 ± 10.72 hours. The duration of estrus varied from 40 to 56 hours with an average of 42.2 ± 3.24 hours in treatment group. Whereas, in control group it ranged from 27 to 52 hours with an average of 36.78 ± 4.12 hours. The furrowing rate was 88 and 90.9 % respectively in treated and control group, while the litter size was 10.37 ± 0.57 and 9.15 +0.34 and number of live born per litter was 9.24 ± 0.43 and 8.78 ± 0.27 respectively. Present finding suggested that it is possible to induce and synchronize fertile estrus with PMSG followed by HCG in weaned sows. The study also suggested that estrus synchronization followed by synchronized furrowing might be practiced to reduced pre-weaning piglet mortality during winter.

  7. Influences of β-HCG administration on carbon isotope ratios of endogenous urinary steroids.

    Science.gov (United States)

    Piper, Thomas; Baume, Norbert; Strahm, Emanuel; Emery, Caroline; Saugy, Martial

    2012-05-01

    Several factors influencing the carbon isotope ratios (CIR) of endogenous urinary steroids have been identified in recent years. One of these should be the metabolism of steroids inside the body involving numerous different enzymes. A detailed look at this metabolism taking into account differences found between steroids excreted as glucuronides or as sulphates and hydrogen isotope ratios of different steroids pointed out possibility of unequal CIR at the main production sites inside the male body - the testes and the adrenal glands. By administration of β-HCG it is possible to strongly stimulate the steroid production within the testes without influencing the production at the adrenal glands. Therefore, this treatment should result in changed CIR of urinary androgens in contrast to the undisturbed pre-treatment values. Four male volunteers received three injections of β-HCG over a time course of 5 days and collected their urine samples at defined intervals after the last administration. Those samples showing the largest response in contrast to the pre-administration urines were identified by steroid profile measurements and subsequent analysed by GC/C/IRMS. CIR of androsterone, etiocholanolone, testosterone, 5α- and 5β-androstanediol and pregnanediol were compared. While pregnanediol was not influenced, most of the investigated androgens showed depleted values after treatment. The majority of differences were found to be statistically significant and nearly all showed the expected trend towards more depleted δ(13)C-values. These results support the hypothesis of different CIR at different production sites inside the human body. The impact of these findings on doping control analysis will be discussed.

  8. Downregulation of LH and FSH receptors after hCG and eCG treatments in the porcine oviduct.

    Science.gov (United States)

    Małysz-Cymborska, I; Andronowska, A

    2016-10-01

    The influence of induction of ovulation and superovulation with eCG and hCG on LH and FSH receptor levels in porcine oviducts on day 3 postcoitum was studied. In experiment I, gilts were assigned into cyclic (control; n = 5) and inseminated (n = 5) groups. In experiment II, there were 3 groups of animals: inseminated (n = 5), induced ovulation/inseminated (750 IU eCG, 500 IU hCG; n = 5) and superovulated/inseminated (1500 IU eCG, 1000 IU hCG; n = 5) gilts. Oviduct tissues were collected 3 d after insemination or PBS infusion. The messenger RNA (mRNA) expression of FSH receptor (FSHR) and luteinizing hormone/chorionic gonadotropin receptor (LH/CGR) was measured by real-time reverse transcription PCR and protein levels using Western blots. Localization of LH/CGR and FSHR-positive cells was studied by immunohistochemical staining. Insemination by itself did not influence mRNA and protein levels of LH/CGR. However, FSHR mRNA expression in the isthmus and ampulla of the oviduct was affected by insemination (P hCG and eCG did not affect LH/CGR and FSHR mRNA expression, either in the isthmus or in the ampulla. Nevertheless, superovulation decreased LH/CGR protein level in the oviductal ampulla (P hCG, especially in high doses, can change LH/CGR and FSHR levels in porcine oviducts. This may in turn alter many signaling pathways, eg, PGs or vascular endothelial growth factor synthesis, and consequently disturb the oviductal environment, with possible detrimental effects on fertilization and/or embryonic development. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Intrafollicular endocrine milieu after addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization.

    Science.gov (United States)

    Thuesen, L L; Andersen, A Nyboe; Loft, A; Smitz, J

    2014-02-01

    The role of human chorionic gonadotropin (hCG) supplementation on the intrafollicular steroid milieu has been studied. The objective of the study was to assess the impact on steroid levels in follicular fluids (FFs) after different doses of hCG supplementation to recombinant FSH for controlled ovarian stimulation. This was a prospective randomized dose-response study conducted at Copenhagen University Hospital, Rigshospitalet, Denmark. From 62 in vitro fertilization patients, 334 FFs were selected for analyses. Patients were treated using a GnRH agonist protocol with recombinant FSH 150 IU/d and randomized from stimulation day 1 to supplementation with hCG: D0, 0 IU/d; D50, 50 IU/d; D100, 100 IU/d; and D150, 150 IU/d. Intrafollicular hormone concentrations in relation to treatment groups, follicular sizes, and embryo quality were measured. In large follicles, hCG supplementation induced a nearly 3-fold increase of estradiol (nanomoles per liter) [D0: 1496; D50: 3138; D100: 4338; D150: 4009 (P D100: 72; D150: 56 (P D100 and the highest in D0. Large follicles giving rise to good-quality embryos had significantly higher estradiol and progesterone levels and estradiol to T, estradiol to androstenedione, and progesterone to estradiol ratios, compared with small follicles, leading to poor-quality embryos. Increasing doses of hCG supplementation markedly stimulated the intrafollicular concentration of both estradiol and androgens, with a shift toward a more androgenic milieu. In large follicles with oocytes giving rise to good-quality embryos, the FFs were significantly more estrogenic than in small follicles with oocytes developing into poor quality embryos.

  10. Detection of hCG Responsive Expression of the Steroidogenic Acute Regulatory Protein in Mouse Leydig Cells

    Directory of Open Access Journals (Sweden)

    Manna Pulak R.

    2004-01-01

    Full Text Available The steroidogenic acute regulatory (StAR protein, a novel mitochondrial protein, is involved in the regulation of steroid hormone biosynthesis through its mediation of the intramitochondrial transport of the steroid substrate, cholesterol, to the cytochrome P450 cholesterol side chain cleavage (P450scc enzyme. The expression of StAR protein is regulated by cAMP-dependent signaling in steroidogenic cells. During the course of our studies in mouse Leydig cells, we employ several methods for studying the regulation of StAR protein expression by human chorionic gonadotropin (hCG. A sensitive quantitative reverse transcription and polymerase chain reaction (RT-PCR was utilized for determining StAR mRNA expression. Stimulation of mLTC-1 mouse Leydig tumor cells with hCG resulted in the coordinate regulation of StAR mRNA expression and progesterone accumulation in a time-response manner. The validity and accuracy of quantitative RT-PCR results in mLTC-1 cells were verified by a competitive PCR approach and were further confirmed in primary cultures of isolated mouse Leydig cells. Immunoblotting studies demonstrated an increase in the levels of the StAR protein in a concentration dependent manner following hCG stimulation in mLTC-1 cells. Northern hybridization analysis revealed three StAR transcripts, all of which were of sufficient size to encode functional StAR protein, and which were coordinately expressed in response to hCG. Collectively, the experimental approaches utilized in the present investigation allow for the demonstration and characterization of hCG mediated regulation of StAR mRNA and StAR protein expression in mouse Leydig cells.

  11. vida humana: cuestiones de método

    Directory of Open Access Journals (Sweden)

    Antonio Pardo Caballos

    2007-01-01

    Full Text Available Para el estudio ético de las intervenciones sobre el comienzo de la vida humana es decisivo conocer cuándo comienza ésta exactamente. Para conseguir este resultado, es necesario combinar conocimientos fi losófi cos sobre la vida y observaciones empíricas de los primeros momentos del desarrollo. A partir de ellos, se puederealizar un razonamiento que permite mostrar que la fecundación establece el momento de aparición de una nueva vida humana. Las refl exiones estrictamente científi cas, y las que basan su razonamiento solamente en aspectos genéticos del comienzo de la vida, son reduccionistas y no pueden determinar propiamente el comienzo de la vida.

  12. Voz humana sem amarras: abordagem a partir de Wolfsohn

    OpenAIRE

    Marambio, Denisse Elena Iturra

    2013-01-01

    Alfred Wolfsohn (1896-1962), alemão, pesquisador da expressão humana por meio da voz. Participou, como soldado, da primeira guerra mundial, o que lhe causou uma neurose de guerra: ponto de partida da formulação de suas ideias sobre a voz humana, principalmente em relação às condições orgânico-funcionais em associação às dimensões emocionais e afetivas da produção e preparação vocal. Wolfsohn desenvolveu uma detalhada proposta de preparação vocal de cantores e atores, embora ...

  13. Gestión humana: tendencias y perspectivas

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    Juan Guillermo Saldarriaga Ríos

    2008-04-01

    Full Text Available En este artículo se hace referencia a las tendencias y las perspectivas de gestión humana que se imponen en el mundo en la actualidad y que, a su manera, pretenden optimizar la administración del personal de la organización y contribuir al desarrollo e incremento de la productividad y la competitividad. Mediante la realización de un Estado del Arte se logran determinar algunas de las tendencias más relevantes en la actualidad y se concluye que, cada vez con mayor fuerza, dichas tendencias se sustentan en discursos que pretenden “rescatar” al ser humano dentro de la organización, lo que no necesariamente se traduce en los procesos de gestión humana que se realizan en las organizaciones nacionales e internacionales.

  14. Naturaleza humana y política en Denis Diderot

    Directory of Open Access Journals (Sweden)

    Pablo Scotto Benito

    2015-02-01

    Full Text Available El presente trabajo se propone relacionar la concepción que Diderot tiene del ser humano con sus ideas políticas. A pesar de que no se pueda hallar en la obra del “filósofo” un tratado sistemático en el que el estudio de la naturaleza humana sirva como fundamentación de un determinado sistema político, la epistemología empirista y el monismo materialista diderotianos, con la consecuente revalorización de las pasiones corporales, conducen a una moral y una política universalistas, acordes con la naturaleza humana y centradas en la felicidad de los individuos.

  15. Mitos y tabúes en la sexualidad humana

    Directory of Open Access Journals (Sweden)

    Ignacio González Labrador

    2002-06-01

    Full Text Available Se realizan consideraciones muy generales sobre el origen de los géneros y cómo esta formación favorece la presencia de mitos y tabúes en la expresión de la sexualidad de la pareja humana.Very general considerations are presented on the origin of genders and how this formation has favored myths and taboos in the expression of the human couple's sexuality.

  16. Relaciones Públicas y Relaciones Humanas: Conceptos y Zonas de Contacto

    OpenAIRE

    Guerrero Portales, Rudy

    2015-01-01

    Como primer antecedente podemos seiialar que Relaciones Humanas considera al hombre como ser-personal y Relaciones Publicas estudia al hombre en su caracter de ser social. En esencia, ambas disciplinas analizan y procuran explicar la conducta del hombre en su naturaleza individual y social, y como unidad comun, ambas utilizan fuentes, mensajes, medios, puhlicos y efcctos. Pero sigamos examinando la autonomia y dependencia de cada una de estas areas.

  17. A busca da transdisciplinaridade nas ciências humanas

    Directory of Open Access Journals (Sweden)

    Aloísio Krohling

    2007-08-01

    Full Text Available Este artigo busca elaborar uma retrospectiva histórica das raízes epistemológicas do pensamento moderno, passando pelo Iluminismo e todas as correntes teóricas, seguidoras da mesma fonte metodológica e epistemológica do SABER INSTRUMENTAL, o que se refletiu nas várias áreas do saber do campo das Ciências Humanas, com o objetivo de mostrar a importância da busca da transdisciplinaridade e da interdisciplinaridade nas Ciências Humanas, com o resgate do paradigma do Múltiplo. A busca da transdisciplinaridade será o fio da meada no sentido de voltar ao MÚLTIPLO heraclitiano e resgatar o “Pantha Rei” das mudanças e contradições da História e da cultura ocidentais. Questiona o atomismo e a fragmentação disciplinar da maioria dos cursos de graduação na área de Ciências Humanas, mormente na Educação, e de modo exacerbado no curso de Direito, com as suas dezenas de disciplinas atomizadas e fragmentadas e sem um fio condutor. É proposta a busca da transdisciplinaridade para o resgate da Metodologia Dialética e da Filosofia da Educação e Filosofia do Direito como as duas grandes alavancas para uma visão e prática holísticas nos Cursos de Educação e Direito bem como na área das Ciências Humanas.

  18. En torno a la realidad humana en Xavier Zubiri

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    Espinoza Lolas, Ricardo

    2016-08-01

    Full Text Available This article inquires into the nature of human reality and its connection to the concept of person in the philosophy of Xavier Zubiri(1898-1983. The methodology of the analysis consists in reviewing the nature of human reality through the prism of noology, i.e., the final period of this author’s work, in order to introduce man from its always incarnate, prominently physical, dimension of human reality. This allows individual development and the historical and social display of the human being from a physical perspective to be represented.Este artículo indaga acerca del carácter de la realidad humana y su relación al concepto de persona en el pensamiento de Xavier Zubiri (1898-1983. La metodología de análisis consiste en revisar el carácter de la realidad humana desde la noología, esto es, la última etapa de la obra del autor, a fin de presentar al hombre desde su dimensión eminentemente física y siempre encarnada de la realidad humana, permitiendo repensar desde una perspectiva física el desarrollo individual, así como también, el despliegue social e histórico del ser humano.

  19. GEOGRAFÍA HUMANA Y GEOMÁTICA

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    Silvana Levi

    2006-06-01

    Full Text Available La geografía humana y la geomática son disciplinas quehan recorrido un camino paralelo en la que a partir de ladécada de 1990, sus especialistas han tratado de acercarsecon miras a la resolución de problemas de índoleespacial. En este trabajo se plantea la relación históricade la geomática con la geografía humana, se le enmarcateóricamente en los estudios de análisis espacial, paradespués ahondar en el diálogo que se ha establecido entreambas disciplinas, y con ello responder a los cuestionamientosde ¿qué se ha hecho por establecer puentesentre ambas? y ¿cómo pueden beneficiarse la una dela otra? Para responder a estas preguntas se analiza eldebate que se dio en la década de los noventa entre losespecialistas en sistemas de información geográfica ycartografía digital para posteriormente, a partir de finalesde los 1990s, las propuestas que se hicieron desde lageografía, que con un enfoque teórico y en un intento pordiscutir el papel del espacio-tiempo en la geografía físicay la humana, y que tocó de manera relevante la relaciónde la geografía con la geomática.

  20. La tarea hermenéutica de las ciencias humanas

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    Rafael Ávila Penagos

    2012-01-01

    Full Text Available En este trabajo el autor sustenta la importancia y pertinencia de la tradición hermenéutica para todos los investigadores de las ciencias humanas. Dos casos paradigmáticos sirven para abrir y cerrar el texto. En ellos se muestra, de manera contundente, el impacto de las actividades hermenéuticas sobre la configuración de nuevos sentidos, el cambio en las maneras de mirar y el acceso a nuevas formas de vida en el universo social. En el intermedio, el autor describe el progresivo distanciamiento de las ciencias humanas respecto al paradigma positivista. Se detiene en la conceptualización de cuatro categorías fundamentales de la actividad hermenéutica: la comprensión, la explicación, la interpretación y la traducción. Sostiene que la traducción del comprender es la tarea complementaria de la comprensión del comprender, e incorpora la propuesta de Paul Ricoeur para una nueva comprensión de la explicación en este ámbito. Finalmente, argumenta que la autocomprensión y la autovaloración de las ciencias humanas dependen de su capacidad reflexiva para considerar sus teorías y sus prácticas como textos susceptibles de autoexamen.

  1. DIGNIDAD HUMANA, DIVERSIDAD CULTURAL Y CALIDAD DE VIDA

    Directory of Open Access Journals (Sweden)

    Édgar Antonio López López

    2009-01-01

    Full Text Available En este artículo, se propone la calidad de vida como una expresión concreta de la dignidad humana que permite superar el relativismo en la discusión bioética sobre la diversidad cultural y los límites de una concepción universalista de los derechos humanos. Después de hacer referencia al proceso mediante el cual las nociones cristianas de dignidad humana y de derecho natural fueron secularizadas, se hace examen de la conservadora crítica culturalista de Lee Kwan yew y de la crítica comunitarista de Charles Taylor a la concepción universal de los derechos humanos. A partir de las respuestas de Thomas Pogge y de Amartya Sen a dichas críticas, fi nalmente se establece la relación que hay entre libertad, calidad de vida y capacidades humanas en la teoría de Sen.

  2. A formação humana em debate

    Directory of Open Access Journals (Sweden)

    Sandra Soares Della Fonte

    2014-06-01

    Full Text Available Este artigo aborda a questão da formação humana a partir do conflito entre formulações educacionais pós-críticas e críticas. De modo mais preciso, problematiza a perspectiva de formação humana das teorizações educacionais pós-críticas, ao mesmo tempo em que sinaliza um possível caminho a ser explorado e desenvolvido pela pedagogia histórico-crítica no enfrentamento das limitações que lhe são impostas. Conclui que a compreensão de omnilateralidade em Marx pode contribuir para inspirar formulações pedagógicas críticas na consolidação de uma concepção humana que supere, de um lado, tendências racionalistas ou cognitivistas e, de outro, perspectivas estetizantes.

  3. PLAC4 and beta-HCG mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21.

    Science.gov (United States)

    Banzola, Irina; Rusterholz, Corinne; Zannoni, Letizia; Rizzo, Nicola; Zhong, Xiao Yan; Caramelli, Elisabetta; Holzgreve, Wolfgang; Farina, Antonio; Hahn, Sinuhe

    2008-12-01

    Beta-human chorionic gonadotropin (HCG) and pregnancy-associated plasma protein (PAPP-A) are placentally produced proteins whose levels are altered in pregnancies with trisomy 21. PLAC4 is located on chromosome 21 and its expression is restricted to the placenta. Here we investigated whether the levels of beta-HCG-, PAPP-A- and PLAC4 mRNA could be able to discriminate pregnancies whose fetus is affected by trisomy 21. Hundred and forty-three blood samples from normal pregnancies and eight samples from trisomic pregnancies were collected. Total RNA was extracted from whole maternal blood, reverse-transcribed and the three mRNAs were quantified by real-time quantitative PCR. Hundred and nine controls were also tested for the serum levels of PAPP-A and HCG proteins. Beta-HCG and PLAC4 mRNAs were detected in all samples, in higher amounts than in plasma, whereas the detection rate for PAPP-A mRNA was below 10%. The levels of beta-HCG mRNA significantly correlated with the circulatory concentrations of the HCG protein. However, neither beta-HCG- nor PLAC4 mRNAs show a significant difference between cases and controls. Maternal blood levels of beta-HCG-, PLAC4- and PAPP-A mRNAs are not useful markers for the screening of pregnancies with trisomy 21 as their concentrations are either not significantly altered (beta-HCG and PLAC4) or too low to be detected (PAPP-A).

  4. Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies: hCG signaling is impaired in trisomy 21 pregnancy

    National Research Council Canada - National Science Library

    Pidoux, Guillaume; Gerbaud, Pascale; Marpeau, Olivier; Guibourdenche, Jean; Ferreira, Fatima; Badet, Josette; Evain-Brion, Danièle; Frendo, Jean-Louis

    2007-01-01

    ...), which is essential to placental development. In trisomy of chromosome 21 (T21) pregnancies, CTs do not fuse and differentiate properly into STs, leading to the secretion of an abnormal and weakly bioactive hCG...

  5. Luteinizing Hormone Receptor Knockout (LuRKO) Mice and Transgenic Human Chorionic Gonadotropin (hCG)-Overexpressing Mice (hCG αβ+) Have Bone Phenotypes

    National Research Council Canada - National Science Library

    Yarram, S. J; Perry, M. J; Christopher, T. J; Westby, K; Brown, N. L; Lamminen, T; Rulli, S. B; Zhang, F.-P; Huhtaniemi, I; Sandy, J. R; Mansell, J. P

    2003-01-01

    Considerable attention has been paid to the role of sex steroids during periods of major skeletal turnover, but the interaction of the gonadotropic hormones, which include LH, FSH, and human chorionic gonadotropin (hCG...

  6. Maternal hCG concentrations in early IVF pregnancies: associations with number of cells in the Day 2 embryo and oocytes retrieved.

    Science.gov (United States)

    Tanbo, T G; Eskild, A

    2015-12-01

    Do number of cells in the transferred cleavage stage embryo and number of oocytes retrieved for IVF influence maternal hCG concentrations in early pregnancies? Compared with transfer of a 2-cell embryo, transfer of a 4-cell embryo results in higher hCG concentrations on Day 12 after transfer, and more than 20 oocytes retrieved were associated with low hCG concentrations. Maternal hCG concentration in very early pregnancy varies considerably among women, but is likely to be an indicator of time since implantation of the embryo into the endometrium, in addition to number and function of trophoblast cells. We followed 1047 pregnancies after IVF/ICSI from oocyte retrieval until Day 12 after embryo transfer. Women were recruited in Norway during the years 2005-2013. Successful pregnancies after transfer of one single embryo that had been cultured for 2 days were included. Maternal hCG was quantified on Day 12 after embryo transfer by chemiluminescence immunoassay, which measures intact hCG and the free β-hCG chain. Information on a successful pregnancy, defined as birth after >16 weeks, was obtained by linkage to the Medical Birth Registry of Norway. Transfer of a 4-cell embryo resulted in higher maternal hCG concentrations compared with transfer of a 2-cell embryo (134.8 versus 87.8 IU/l, P 20) was associated with low hCG concentrations (P hCG concentrations in early pregnancy. Although embryo transfer was performed at the same time after fertilization, we do not know the exact time of implantation. A further limitation to our study is that the number of pregnancies after transfer of a 2-cell embryo was small (27 cases). Number of cells in the transferred embryo and number of oocytes retrieved may influence the conditions and timing for embryo implantation in different ways and thereby influence maternal hCG concentrations. Such knowledge may be important for interpretation of hCG concentrations in early pregnancy. © The Author 2015. Published by Oxford University

  7. Endocrine effects of hCG supplementation to recombinant FSH throughout controlled ovarian stimulation for IVF: a dose–response study

    DEFF Research Database (Denmark)

    Thuesen, Leif; Smitz, J; Loft, A;

    2013-01-01

    To analyse the endocrine response in relation to the Δ-4 and Δ-5 pathways of ovarian steroidogenesis after different doses of human chorionic gonadotrophin (hCG) supplementation to recombinant FSH from Day 1 of controlled ovarian stimulation for IVF.......To analyse the endocrine response in relation to the Δ-4 and Δ-5 pathways of ovarian steroidogenesis after different doses of human chorionic gonadotrophin (hCG) supplementation to recombinant FSH from Day 1 of controlled ovarian stimulation for IVF....

  8. The impact of different time intervals between hCG priming and oocyte retrieval on ART outcomes

    Directory of Open Access Journals (Sweden)

    Mohammad Hadi Bahadori

    2013-01-01

    Full Text Available Background: Abnormal oocyte morphology has been associated with the hormonal environment to which the gametes are exposed. Objective: In this study, we evaluated the oocytes morphology, fertilization rate, embryos quality, and implantation rate resulted of retrieved oocytes in different times after human chorionic gonadotrophin (HCG administration. Materials and Methods: A total of 985 metaphase II oocytes were retrieved 35, 36, 37 and 38 h after the injection of HCG as groups 1, 2, 3, and 4 respectively. Oocyte morphology was divided into (I normal morphology, (II extracytoplasmic abnormalities, (III cytoplasmic abnormalities and (IV intracytoplasmic vacuoles and in each group, oocytes were evaluated according to this classification. Results: Extracytoplasmic abnormalities were encountered in 17.76% and 31.1% of these oocytes (groups 3 and 4 respectively, p=0.007 in comparison with 12.23% group 2. Cytoplasmic abnormalities in group 4 were higher than other groups. 23.88% (p=0.039 and 43.25% (p=0.089 of resulted 2PN (two pronucleus from groups 3 and 4 showed grade Z3 respectively in comparison to group 2 (16.44%. Normal and various categories of abnormal oocytes did not differ regarding fertilization and cleavage rates (p=0.061. However, group 4 showed significant difference in the rate of embryos fragmentation (grade III and IV embryo in comparison with group 2 (40.96% vs. 24.93%, p=0.078. The pregnancy rate was higher in G2 and G3 groups (28.5 and 24.13% respectively. Conclusion: Oocyte retrieval time following HCG priming affected on oocyte morphology, 2PN pattern and embryos qualities subsequently. Both good quality embryo formation and pregnancy outcomes were noticeably higher when oocytes were retrieved 36 h after HCG priming in ART program.

  9. Rabia humana en el Valle del Cauca, Colombia, 1992

    Directory of Open Access Journals (Sweden)

    María Teresa Restrepo de Meza

    2014-11-01

    Full Text Available Se presenta un caso de encefalitis rábica sin sospecha clínica en una mujer de 20 años de edad. El diagnóstico se comprobó con la técnica de inmunofluorescencia directa para antígeno rábico en tejido cerebral fijado en formalina. El carácter esporádico de la rabia humana en la actualidad en el Valle del Cauca exige mantener la vigilancia epidemiológica y considerar esta posibilidad en todo caso de encefalitis de causa no aclarada.

  10. Antropologia Forense e Identificação Humana

    OpenAIRE

    Silva, Joana Trigo da Silva de Oliveira e

    2015-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária A identificação de vítimas mortais é uma necessidade das sociedades, por razões jurídicas, sociais e humanitárias. A Antropologia Forense é uma das subdisciplinas da Antropologia Física que se dedica à identificação humana, nomeadamente em investigações arqueológicas, criminais e de desastres de massa. A Antropologia Forense...

  11. La importancia de la escala humana para la ciudad

    OpenAIRE

    Soldevilla Del Prado, Luis

    1988-01-01

    Generalmente cuando en arquitectura y urbanismo hablamos de escala humana nos estamos refiriendo a la utilización del hombre como patrón de medida para el establecimiento de las proporcionalidades geométricas, armónicas, justas y placenteras. "La revolución humanística había desplazado de nuevo la tención desde Dios al Hombre…El hombre encontraba de nuevo la medida de las cosas…por lo que la búsqueda de los módulos y de las proporciones, deducidas contemporáneamente de la de los intervalos...

  12. Vírus da Imunodeficiência Humana em Odontopediatria

    OpenAIRE

    Nogueira, Hugo Miguel Figueiredo

    2014-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária A Síndrome da Imunodeficiência Adquirida é uma lesão infeciosa letal causada pelo Vírus da Imunodeficiência Humana, que afeta principalmente linfócitos T CD4+, levando a uma imunossupressão progressiva e consequentes infeções oportunistas graves. Os doentes com Síndrome da Imunodeficiência Adquirida não morrem portanto da...

  13. Formas predominantes de hormona de crecimiento humana (hgh en sueros

    Directory of Open Access Journals (Sweden)

    Martha L. Pinzón

    2010-07-01

    Full Text Available En este trabajo se compararon las formas predominantes de la Hormona de Crecimiento Humana (hGH, proveniente de sueros de pacientes con hipersecreción hormonal, para determinar los cambios que presenta en ellas y que puedan servir de diagnóstico para la detección de patologías, tales como acromegalia, como también alteraciones en el metabolismo degradativo de la proteína o en la unión a sus receptores específicos.

  14. Bases anatómicas de la marcha humana

    OpenAIRE

    Martín Nogueras, Ana María

    1995-01-01

    INTRODUCCIÓN: Es importante para el fisioterapeuta conocer el patrón de marcha normal a fin de disponer del modelo a seguir durante la recuperación funcional. OBJETIVO: Describir el patrón de marcha normal. METODOLOGÍA: Revisión bibliográfica de los principales textos y artículos. RESULTADOS: Se presenta de forma clara y precisa la descripción de las principales fases de la marcha humana incluyendo los aspectos más relevantes para la fisioterapia en la recuperación funcional de los s...

  15. BIOACCESIBILIDAD ORAL HUMANA DE METALES PESADOS EN SUELOS URBANOS CONTAMINADOS

    OpenAIRE

    QUILODRAN ROJAS, CRISTIAN ALEX

    2014-01-01

    En este estudio se evaluó la bioaccesibilidad oral humana de cadmio, cinc, cobre y plomo en un suelo urbano contaminado y cómo influyen los cambios físicos y químicos producidos al incorporar al suelo materia orgánica y metales. Para este fin se utilizó un suelo de la serie Mapocho, del orden Inceptisol, recolectado en el sector de La Farfana en la ciudad de Santiago, Chile. El suelo se trató con ácidos húmicos y metal para obtener suelos con diferentes niveles de materia orgánica y de ...

  16. Seroprevalencia de la toxoplasmosis humana en Córdoba

    OpenAIRE

    Pérez-Rendón González, J.; Moreno Montañez, T.; Becerra Martell, C.; Martínez Cruz, Setefilla

    1992-01-01

    Se realiza un estudio sobre seroprevalencia de la toxoplasmosis humana en Córdoba, mediante inmunofluorescencia indirecta y hemaglutinación indirecta. La muestra encuestada se compone de 443 sueros, 356 personas supuestamente sanas (estudiantes fundamentalmente) y 87, consideradas de “alto riesgo” (enfermos del Hospital “Reina Sofía”). La positividad obtenida para el total de la muestra ha sido del 43,79 % con IFI y 53,50 % para HAI. Con respecto al sexo, la prevale...

  17. CIENCIAS HUMANAS Y EMERGENCIA DE LA EDAD DIGITAL

    OpenAIRE

    Fischer, Hervé

    2013-01-01

    Estamos pasando de la era del fuego a la era digital, o sea, de la era de la energía, que incluye el fuego, el viento, el agua, la electricidad y la energía nuclear, a la era de la información. Pasamos así del binomio energía-materia a un nuevo paradigma epistemológico e instrumental, el de una codificación binaria y de una programación algorítmica con las cuales pretendemos reinterpretar el universo e instrumentarlo con una nueva potencia humana superior a la de las leyes habituales de la na...

  18. Estudos sobre a estabilidade do desenho da figura humana (DHF)

    OpenAIRE

    Taborda, Alejandra; UNIVERSIDAD NACIONAL DE SAN LUIS; Barbenza, Claribel M. de; UNIVERSIDAD NACIONAL DE SAN LUIS

    2008-01-01

    Com o intuito de pesquisar a estabilidade do desenho da figura humana (DHF) e a pertinência das modificações feitas pela autora deste trabalho, comparam-se as normas de revalidação para crianças de 5 e 6 anos elaboradas por Koppitz (1968), e as desenvolvidas em Ottawa por Groves e Fried (1991) com as elaboradas por Taborda-Barbenza em San Luis, Mendoza e San Juan (Argentina, 1993). Este estudo comparativo realizou-se também em 127 crianças de 4 anos de San Luis e Villa Mercedes, considerando ...

  19. "Blade Runner" o la pregunta por la dignidad humana

    OpenAIRE

    García Manrique, Ricardo

    2006-01-01

    Al pensar en la relación entre el fundamento de la dignidad humana y la resolución de algunos problemas bioéticos, me vino a la cabeza Blade Runner, la película de Ridley Scott basada en un relato de Philip K. Dick que lleva el extravagante título de ¿Sueñan los androides con ovejas eléctricas? (extravagante si vemos la película pero no tanto si leemos el relato)...

  20. La importancia de la escala humana para la ciudad

    OpenAIRE

    Soldevilla Del Prado, Luis

    1988-01-01

    Generalmente cuando en arquitectura y urbanismo hablamos de escala humana nos estamos refiriendo a la utilización del hombre como patrón de medida para el establecimiento de las proporcionalidades geométricas, armónicas, justas y placenteras. "La revolución humanística había desplazado de nuevo la tención desde Dios al Hombre…El hombre encontraba de nuevo la medida de las cosas…por lo que la búsqueda de los módulos y de las proporciones, deducidas contemporáneamente de la de los intervalos...

  1. Rnas inhibidores frente al virus de la inmunodeficiencia humana

    OpenAIRE

    S??nchez Luque, Francisco Jos??

    2012-01-01

    En la presente tesis se describe la generaci??n de peque??as mol??culas de RNA con funci??n inhibidora frente al Virus de la Inmunodeficiencia Humana de Tipo 1 (VIH-1). Este virus es el agente causal del S??ndrome de Inmunodeficiencia Adquirida y perteneciente al g??nero Lentivirus de la familia Retroviridae. El virus presenta una alternancia en cuanto al tipo de material gen??tico en su ciclo de vida, siendo RNA en las part??culas virales y DNA en el provirus (durante la fase de latencia o e...

  2. CAN INITIAL βHCG VALUES PREDICT THE NEED FOR SECOND DOSE OF METHOTREXATE IN MEDICAL MANAGEMENT OF ECTOPIC PREGNANCY?

    Directory of Open Access Journals (Sweden)

    Priya Narayanan

    2016-09-01

    Full Text Available INTRODUCTION Prediction of requirement of second dose of methotrexate in patients treated with single dose would help in guiding treatment and counseling. The aim of this study is to determine whether pretreatment beta HCG values can predict the need for second dose of methotrexate in medically managed ectopic pregnancy. MATERIALS AND METHODS 46 women with ectopic pregnancies who were managed medically were included. The median of beta HCG titres on day 1, day 4 and day 7 was assessed in patients who responded to single dose methotrexate and those who required a second dose. RESULTS Out of the 46 patients studied, 41 responded to medical treatment (success 91%. 14 out of 41 required second dose of methotrexate (34%. Two patients required third dose of methotrexate. Five patients required surgery. DISCUSSION The median of day 1 and day 4 beta HCG values were not statistically different between those who responded to single dose methotrexate and those who required a second dose. Only day 7 values were found to be different. CONCLUSION The beta-hCG titre on day 1 and day 4 is not a predictor of requirement of second dose of methotrexate.

  3. Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF

    Directory of Open Access Journals (Sweden)

    Session Donna R

    2010-03-01

    Full Text Available Abstract Background Administration of recombinant luteinizing hormone (rLH in controlled ovarian hyperstimulation may benefit a subpopulation of patients. However, late follicular phase administration of high doses of rLH may also reduce the size of the follicular cohort and promote monofollicular development. Methods To determine if rLH in late follicular development had a negative impact on follicular growth and oocyte yield, IVF patients in our practice who received rFSH and rLH for the entire stimulation were retrospectively compared with those that had the rLH discontinued at least two days prior to hCG trigger. Results The two groups had similar baseline characteristics before stimulation with respect to age, FSH level and antral follicle count. However, the group which had the rLH discontinued at least two days prior to their hCG shot, had a significantly higher number of oocytes retrieved, including a higher number of MII oocytes and number of 2PN embryos. Conclusions When using rLH for controlled ovarian hyperstimulation, administering it from the start of stimulation and stopping it in the late follicular phase, at least two days prior to hCG trigger, may increase oocyte and embryo yield.

  4. Effect of GnRH and hCG on progesterone concentration and ovarian and luteal blood flow in diestrous mares.

    Science.gov (United States)

    Brito, L F C; Baldrighi, J M; Wolf, C A; Ginther, O J

    2017-01-01

    The objective of the present study was to investigate the effect of reproductive hormones (GnRH, hCG, LH and progesterone) on the regulation of corpus luteum (CL) and ovarian blood flow. Diestrous mares received a single treatment of saline, 100μg gonadorelin (GnRH), or 1500IU hCG 10days after ovulation. Plasma LH and progesterone concentrations, resistance index (RI) for ovarian artery blood-flow, and percentage of corpus luteum (CL) with color-Doppler signals of blood flow were determined immediately before treatment (hour 0) and at hours 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, and 6. In the GnRH group, LH increased (Pblood-flow signals was greater at hour 0.5 in the GnRH group than in the saline group and was intermediate in the hCG group. The similarity among groups in progesterone concentration indicated that changes in progesterone were not involved in the GnRH and hCG stimulation of ovarian vascular perfusion. Effects of treatment might have been mediated through LH; however, since hCG biological activity is primarily LH-like, the differences in timing and degree of ovarian and luteal blood flow changes after GnRH or hCG administration in the present study suggest that GnRH might have a direct effect on ovarian blood vessels and vascular control.

  5. Predictive value of CA125, VEGF,β-HCG in the early diagnosis of ectopic gestation and drug conservative treatment prognosis

    Institute of Scientific and Technical Information of China (English)

    Hua Shi; Shao-Hua Pei

    2016-01-01

    Objective:To investigate the predictive value of carbohydrate antigen 125 (CA125), vascular endothelial growth factor (VEGF),β-human chorionic gonadotropin (β-HCG) in the early diagnosis of ectopic gestation and its prognosis of the patients.Method:A total of 125 patients with ectopic gestation treated in our hospital from January 2015 to October 2015 were selected as the research object, and 120 patients with normal intrauterine pregnancy after routine physical examination were selected as the control group. The serum levels of CA125, VEGF,β-HCG in two groups were determined with ELISA.Results:The serum levels of CA125, VEGF in ectopic gestation group were significantly higher than control groups, while the level ofβ-HCG was lower than the normal control group. The levels of CA125, VEGF of effective group in patients with ectopic gestation were lower than ineffective group, while the level ofβ-HCG was higher than ineffective group. The detection area, sensitivity, specificity, positive predictive value, negative predictive value under the ROC curve were greater than single index detection when combined the detection of serum CA125, VEGF,β-HCG.Conclusion:the detection of serum CA125, VEGF,β-HCG can be used as the evaluation index in the early diagnosis and prognosis of ectopic gestation, by combing various indexes detection to improve the clinical diagnosis accuracy for ectopic gestation, and the detection method is simple and fast that worth clinical promotion.

  6. WITNESSING GAS MIXING IN THE METAL DISTRIBUTION OF THE HICKSON COMPACT GROUP HCG 31

    Energy Technology Data Exchange (ETDEWEB)

    Torres-Flores, S.; Alfaro-Cuello, M. [Departamento de Física, Universidad de La Serena, Av. Cisternas 1200, La Serena (Chile); De Oliveira, C. Mendes [Instituto de Astronomia, Geofísica e Ciências Atmosféricas da Universidade de São Paulo, Cidade Universitária, CEP:05508-900, São Paulo, SP (Brazil); Amram, P. [Aix Marseille Université, CNRS, LAM (Laboratoire d' Astrophysique de Marseille) UMR 7326, F-13388, Marseille (France); Carrasco, E. R. [Gemini Observatory/AURA, Southern Operations Center, Casilla 603, La Serena (Chile); De Mello, D. F., E-mail: storres@dfuls.cl [Catholic University of America, Washington, DC 20064 (United States)

    2015-01-01

    We present for the first time direct evidence that in a merger of disk galaxies, the pre-existing central metallicities will mix as a result of gas being transported in the merger interface region along the line that joins the two coalescing nuclei. This is shown using detailed two-dimensional kinematics as well as metallicity measurements for the nearby ongoing merger in the center of the compact group HCG 31. We focus on the emission line gas, which is extensive in the system. The two coalescing cores display similar oxygen abundances. While in between the two nuclei, the metallicity changes smoothly from one nucleus to the other indicating a mix of metals in this region, which is confirmed by the high-resolution Hα kinematics (R = 45,900). This nearby system is especially important because it involves the merging of two fairly low-mass and clumpy galaxies (LMC-like galaxies), making it an important system for comparison with high-redshift galaxies.

  7. Suzaku Observation of HCG 62: Temperature, Abundance, and Extended Hard X-ray Emission Profiles

    CERN Document Server

    Tokoi, Kazuyo; Ishisaki, Yoshitaka; Ohashi, Takaya; Yamasaki, Noriko Y; Nakazawa, Kazuhiro; Matsushita, Kyoko; Fukazawa, Yasushi; Hoshino, Akio; Tamura, Takayuki; Egawa, Chihiro; Kawano, Naomi; Ota, Naomi; Isobe, Naoki; Kawaharada, Madoka; Awaki, Hisamitsu; Hughes, John P

    2007-01-01

    We present results of 120 ks observation of a compact group of galaxies HCG~62 ($z=0.0145$) with Suzaku XIS and HXD-PIN\\@. The XIS spectra for four annular regions were fitted with two temperature {\\it vapec} model with variable abundance, combined with the foreground Galactic component. The Galactic component was constrained to have a common surface brightness among the four annuli, and two temperature {\\it apec} model was preferred to single temperature model. We confirmed the multi-temperature nature of the intra-group medium reported with Chandra and XMM-Newton, with a doughnut-like high temperature ring at radii 3.3--6.5$'$ in a hardness image. We found Mg, Si, S, and Fe abundances to be fairly robust. We examined the possible ``high-abundance arc'' at $\\sim 2'$ southwest from the center, however Suzaku data did not confirm it. We suspect that it is a misidentification of an excess hot component in this region as the Fe line. Careful background study showed no positive detection of the extended hard X-ra...

  8. Galaxy evolution in a complex environment: a multi-wavelength study of HCG 7

    CERN Document Server

    Konstantopoulos, I S; Fedotov, K; Durrell, P R; Heiderman, A; Elmegreen, D M; Charlton, J C; Hibbard, J E; Tzanavaris, P; Chandar, R; Johnson, K E; Maybhate, A; Zabludoff, A E; Gronwall, C; Szathmary, D; Hornschemeier, A E; English, J; Whitmore, B; de Oliveira, C Mendes; Mulchaey, J S

    2010-01-01

    [Abridged] The environment where galaxies are found heavily influences their evolution. Close groupings, like the cores of galaxy clusters or compact groups, evolve in ways far more dramatic than their isolated counterparts. We have conducted a multiwavelength study of HCG7, consisting of four giant galaxies: 3 spirals and 1 lenticular. We use Hubble Space Telescope (HST) imaging to identify and characterize the young and old star cluster populations. We find young massive clusters (YMC) mostly in the three spirals, while the lenticular features a large, unimodal population of globular clusters (GC) but no detectable clusters with ages less than ~Gyr. The spatial and approximate age distributions of the ~300 YMCs and ~150 GCs thus hint at a regular star formation history in the group over a Hubble time. While at first glance the HST data show the galaxies as undisturbed, our deep ground-based, wide-field imaging that extends the HST coverage reveals faint signatures of stellar material in the intra-group medi...

  9. Exposición humana a disruptores endocrinos

    Directory of Open Access Journals (Sweden)

    A. Rivas

    2004-01-01

    Full Text Available Numerosos estudios han asociado las patologías observadas en distintas especies animales y en el hombre con la exposición a contaminantes medio ambientales con actividad hormonal. Se ha acuñado el término de disruptores endocrinos (Endocrine Disrupting Chemicals / EDCs para definir el conjunto de compuestos químicos que interaccionan con el sistema endocrino, sobre el que inducen efectos potencialmente debidos a su capacidad para:1 mimetizar la acción de las hormonas endógenas; 2 antagonizar la acción de las hormonas; 3 alterar su patrón de síntesis y metabolismo; o bien 4 modular los niveles de los receptores correspondientes.La exposición humana a disruptores endocrinos es universal y puede provenir de numerosas fuentes. Además, los compuestos acumulados en la grasa son transmitidos a la descendencia a través de la madre durante la gestación y después de la lactancia.Los efectos sobre la salud humana de la exposicición continua a los disruptores endocrinos necesitan ser investigados en más profundidad.

  10. Estudo retrospectivo da peste humana no Nordeste oriental do Brasil

    Directory of Open Access Journals (Sweden)

    Dalva A. Mello

    1970-02-01

    Full Text Available Utilizando dados do Departamento Nacional de Endemias Rurais, o autor faz um estudo retrospectivo da peste humana no Nordeste Oriental do Brasil no período de 1935-1967. Os aspectos epidemiológicos abordados foram os seguintes: morbidade, mortalidade, letalidade, "point" epidêmicos, tendência secular e variações mensais. Os coeficientes de morbidade e mortalidade variaram muito. A letalidade apresentou-se bastante alta. Dez anos de "point" epidêmicos foram registrados no periodo estudado. A análise estatística dos casos distribuídos por mês mostrou que a peste humana atinge o pcnto máximo na estação sêca. Ficou demonstrada urna variação cíclica da doença, em que aumentos e decréscimos ocorrem em períodos que variam de 6 a 12 anos.

  11. Diagnóstico y Tratamiento de la Leptospirosis Humana

    Directory of Open Access Journals (Sweden)

    Beatriz Rodríguez Alonso

    2001-02-01

    Full Text Available Se presenta un trabajo de revisión del tema de la leptospirosis humana por constituir un problema de salud en nuestro país y en gran parte del mundo. Tenemos en consideración el análisis de los pilares sustanciales para el diagnóstico de cualquier entidad: epidemiología, cuadro clínico y laboratorio; además la importancia del diagnóstico anatomopatológico en los fallecidos por leptospirosis humana, brindándose los aspectos patognómicos concernientes a esta enfermedad. Así mismo se exponen los esquemas actuales del tratamiento de elección para CubaA review is made on the topic of human leptospirosis, since it is a health problem in our country and in many other parts of the world. We take into consideration the analysis of the essential milestones for the diagnosis of any entity: epidemiology, clinical picture and laboratory. The importance of the anatomopathological diagnosis in the dead due to human leptospirosis is also taken into account. The pathognomonic aspects in relation to this disease are given here. Likewise, the current schemes of the elective treatment for Cuba are dealt with

  12. Human Chorionic Gonadotropin (hCG) Regression Curve for Predicting Response to EMA/CO (Etoposide, Methotrexate, Actinomycin D, Cyclophosphamide and Vincristine) Regimen in Gestational Trophoblastic Neoplasia.

    Science.gov (United States)

    Rattanaburi, Athithan; Boonyapipat, Sathana; Supasinth, Yuthasak

    2015-01-01

    An hCG regression curve has been used to predict the natural history and response to chemotherapy in gestational trophoblastic disease. We constructed hCG regression curves in high-risk gestational trophoblastic neoplasia (GTN) treated with EMA/CO and identified an optimal hCG level to detect EMA/CO resistance in GTN. Eighty-one women with GTN treated with EMA/CO were classified as primary high-risk GTN (n=65) and single agent-resistance GTN (n=16). The hCG levels prior to each course of chemotherapy were plotted in the 10th, 50th, and 90th percentiles to construct the hCG regression curves. Diagnostic performance was evaluated for an optimal cut-off value. The median hCG levels were 264,482 mIU/mL mIU/mL and 495.5 mIU/mL mIU/mL for primary high-risk GTN and single agent-resistance GTN, respectively. The 50th percentile of the hCG level in primary high-risk GTN and single agent-resistance turned to normal before the 4th and the 2nd course of chemotherapy, respectively. The 90th percentile of the hCG level in primary high-risk GTN and single agent-resistance turned to normal before the 9th and the 2nd course of chemotherapy, respectively. The hCG level of ≥118.6 mIU/mL mIU/mL at the 5thcourse of EMA/CO predicted the EMA/CO resistance in primary high-risk GTN patients with a sensitivity of 85.7% and a specificity of 100%. EMA/CO resistance in primary high-risk GTN can be predicted by using an hCG regression curve in combination with the cut-off value of 118.6 mIU/mL at the 5thcourse of chemotherapy.

  13. Androgen-responsive non-coding small RNAs extend the potential of HCG stimulation to act as a bioassay of androgen sufficiency.

    Science.gov (United States)

    Rodie, M E; Mudaliar, M A V; Herzyk, P; McMillan, M; Boroujerdi, M; Chudleigh, S; Tobias, E S; Ahmed, S F

    2017-10-01

    It is unclear whether a short-term change in circulating androgens is associated with changes in the transcriptome of the peripheral blood mononuclear cells (PBMC). To explore the effect of hCG stimulation on the PBMC transcriptome, 12 boys with a median age (range) of 0.7 years (0.3, 11.2) who received intramuscular hCG 1500u on 3 consecutive days as part of their investigations underwent transcriptomic array analysis on RNA extracted from peripheral blood mononuclear cells before and after hCG stimulation. Median pre- and post-hCG testosterone for the overall group was 0.7 nmol/L (hCG stimulation with a pre and post median serum testosterone of hCG effects, all 9 of the hCG responders consistently demonstrated a 20% or greater increase in the expression of piR-37153 and piR-39248, non-coding PIWI-interacting RNAs (piRNAs). In addition, of the 9 responders, 8, 6 and 4 demonstrated a 30, 40 and 50% rise, respectively, in a total of 2 further piRNAs. In addition, 3 of the responders showed a 50% or greater rise in the expression of another small RNA, SNORD5. On comparing fold-change in serum testosterone with fold-change in the above transcripts, a positive correlation was detected for SNORD5 (P = 0.01). The identification of a dynamic and androgen-responsive PBMC transcriptome extends the potential value of the hCG test for the assessment of androgen sufficiency. © 2017 The authors.

  14. Sliding scale HCG trigger yields equivalent pregnancy outcomes and reduces ovarian hyperstimulation syndrome: Analysis of 10,427 IVF-ICSI cycles.

    Science.gov (United States)

    Gunnala, Vinay; Melnick, Alexis; Irani, Mohamad; Reichman, David; Schattman, Glenn; Davis, Owen; Rosenwaks, Zev

    2017-01-01

    To evaluate pregnancy outcomes and the incidence of ovarian hyperstimulation syndrome (OHSS) using a sliding scale hCG protocol to trigger oocyte maturity and establish a threshold level of serum b-hCG associated with optimal oocyte maturity. Retrospective cohort. Academic medical center. Fresh IVF cycles from 9/2004-12/2011. 10,427 fresh IVF-ICSI cycles met inclusion criteria. hCG was administered according to E2 level at trigger: 10,000IU vs. 5,000IU vs. 4,000IU vs. 3,300IU vs. dual trigger (2mg leuprolide acetate + 1,500IU hCG). Serum absorption of hCG was assessed according to dose and BMI. Oocyte maturity was analyzed according to post-trigger serum b-hCG. Fertilization, clinical pregnancy, live birth and OHSS rates were examined by hCG trigger dose. Post-trigger serum b-hCG 20-30, 30-40, and 40-50 mIU/mL was associated with reduced oocyte maturity as compared b-hCG >50 (67.8% vs. 71.4% vs. 73.3% vs. 78.9%, respectively, PhCG 20-50 mIU/mL was associated with a 40.1% reduction in live birth (OR 0.59, 95% CI 0.41-0.87). No differences in IVF outcomes per retrieval were seen for varying doses of hCG or dual trigger when controlling for patient age. The incidence of moderate to severe OHSS was 0.13% (n = 14) and severe OHSS was 0.03% (n = 4) of cycles. Moderate stimulation with sliding scale hCG at trigger and fresh transfer is associated with low rates of OHSS and favorable pregnancy rates. Doses as low as 3,300IU alone or dual trigger with 1,500IU are sufficient to facilitate oocyte maturity.

  15. Witnessing Gas Mixing in the Metal Distribution of the Hickson Compact Group HCG 31

    Science.gov (United States)

    Torres-Flores, S.; Mendes de Oliveira, C.; Amram, P.; Alfaro-Cuello, M.; Carrasco, E. R.; de Mello, D. F.

    2015-01-01

    We present for the first time direct evidence that in a merger of disk galaxies, the pre-existing central metallicities will mix as a result of gas being transported in the merger interface region along the line that joins the two coalescing nuclei. This is shown using detailed two-dimensional kinematics as well as metallicity measurements for the nearby ongoing merger in the center of the compact group HCG 31. We focus on the emission line gas, which is extensive in the system. The two coalescing cores display similar oxygen abundances. While in between the two nuclei, the metallicity changes smoothly from one nucleus to the other indicating a mix of metals in this region, which is confirmed by the high-resolution Hα kinematics (R = 45,900). This nearby system is especially important because it involves the merging of two fairly low-mass and clumpy galaxies (LMC-like galaxies), making it an important system for comparison with high-redshift galaxies. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the Science and Technology Facilities Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), Ministério da Ciência e Tecnologia (Brazil) and Ministerio de Ciencia, Tecnología e Innovación Productiva (Argentina) - Observing run: GS-2012B-Q-60.

  16. Deep Chandra observations of HCG 16. I. Active nuclei, star formation, and galactic winds

    Energy Technology Data Exchange (ETDEWEB)

    O' Sullivan, E.; Zezas, A.; Vrtilek, J. M.; David, L. P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Giacintucci, S. [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Trevisan, M. [Instituto Nacional de Pesquisas Espaciais, Av. dos Astronautas 1758, 12227-010, São José dos Campos (Brazil); Ponman, T. J.; Raychaudhury, S. [School of Physics and Astronomy, University of Birmingham, Birmingham, B15 2TT (United Kingdom); Mamon, G. A., E-mail: eosullivan@cfa.harvard.edu [Institut d' Astrophysique de Paris (UMR 7095 CNRS and UMPC), 98 bis Bd Arago, F-75014 Paris (France)

    2014-10-01

    We present new, deep Chandra X-ray and Giant Metrewave Radio Telescope 610 MHz observations of the spiral-galaxy-rich compact group HCG 16, which we use to examine nuclear activity, star formation, and high-luminosity X-ray binary populations in the major galaxies. We confirm the presence of obscured active nuclei in NGC 833 and NGC 835, and identify a previously unrecognized nuclear source in NGC 838. All three nuclei are variable on timescales of months to years, and for NGC 833 and NGC 835 this is most likely caused by changes in accretion rate. The deep Chandra observations allow us to detect for the first time an Fe Kα emission line in the spectrum of the Seyfert 2 nucleus of NGC 835. We find that NGC 838 and NGC 839 are both starburst-dominated systems, with only weak nuclear activity, in agreement with previous optical studies. We estimate the star formation rates in the two galaxies from their X-ray and radio emission, and compare these results with estimates from the infrared and ultraviolet bands to confirm that star formation in both galaxies is probably declining after galaxy-wide starbursts were triggered ∼400-500 Myr ago. We examine the physical properties of their galactic superwinds, and find that both have temperatures of ∼0.8 keV. We also examine the X-ray and radio properties of NGC 848, the fifth largest galaxy in the group, and show that it is dominated by emission from its starburst.

  17. Air-suspended TiO2-based HCG reflectors for visible spectral range

    Science.gov (United States)

    Hashemi, Ehsan; Bengtsson, Jörgen; Gustavsson, Johan; Carlsson, Stefan; Rossbach, Georg; Haglund, Åsa

    2015-02-01

    For GaN-based microcavity light emitters, such as vertical-cavity surface-emitting lasers (VCSELs) and resonant cavity light emitting diodes (RCLEDs) in the blue-green wavelength regime, achieving a high reflectivity wide bandwidth feedback mirror is truly challenging. The material properties of the III-nitride alloys are hardly compatible with the conventional distributed Bragg reflectors (DBRs) and the newly proposed high-contrast gratings (HCGs). Alternatively, at least for the top outcoupling mirror, dielectric materials offer more suitable material combinations not only for the DBRs but also for the HCGs. HCGs may offer advantages such as transverse mode and polarization control, a broader reflectivity spectrum than epitaxially grown DBRs, and the possibility to set the resonance wavelength after epitaxial growth by the grating parameters. In this work we have realized an air-suspended TiO2 grating with the help of a SiO2 sacrificial layer. The deposition processes for the dielectric layers were fine-tuned to minimize the residual stress. To achieve an accurate control of the grating duty cycle, a newly developed lift-off process, using hydrogen silesquioxan (HSQ) and sacrificial polymethyl-methacrylate (PMMA) resists, was applied to deposit the hard mask, providing sub-10 nm resolution. The finally obtained TiO2/air HCGs were characterized in a micro-reflectance measurement setup. A peak power reflectivity in excess of 95% was achieved for TM polarization at the center wavelength of 435 nm, with a reflectivity stopband width of about 80 nm (FWHM). The measured HCG reflectance spectra were compared to corresponding simulations obtained from rigorous coupled-wave analysis and very good agreement was found.

  18. Deep Chandra Observations of HCG 16. I. Active Nuclei, Star Formation, and Galactic Winds

    Science.gov (United States)

    O'Sullivan, E.; Zezas, A.; Vrtilek, J. M.; Giacintucci, S.; Trevisan, M.; David, L. P.; Ponman, T. J.; Mamon, G. A.; Raychaudhury, S.

    2014-10-01

    We present new, deep Chandra X-ray and Giant Metrewave Radio Telescope 610 MHz observations of the spiral-galaxy-rich compact group HCG 16, which we use to examine nuclear activity, star formation, and high-luminosity X-ray binary populations in the major galaxies. We confirm the presence of obscured active nuclei in NGC 833 and NGC 835, and identify a previously unrecognized nuclear source in NGC 838. All three nuclei are variable on timescales of months to years, and for NGC 833 and NGC 835 this is most likely caused by changes in accretion rate. The deep Chandra observations allow us to detect for the first time an Fe Kα emission line in the spectrum of the Seyfert 2 nucleus of NGC 835. We find that NGC 838 and NGC 839 are both starburst-dominated systems, with only weak nuclear activity, in agreement with previous optical studies. We estimate the star formation rates in the two galaxies from their X-ray and radio emission, and compare these results with estimates from the infrared and ultraviolet bands to confirm that star formation in both galaxies is probably declining after galaxy-wide starbursts were triggered ~400-500 Myr ago. We examine the physical properties of their galactic superwinds, and find that both have temperatures of ~0.8 keV. We also examine the X-ray and radio properties of NGC 848, the fifth largest galaxy in the group, and show that it is dominated by emission from its starburst.

  19. A precariedade humana e a existência estilizada

    Directory of Open Access Journals (Sweden)

    Rita Paiva

    2013-04-01

    Full Text Available Este artigo tematiza o desamparo vivenciado pela consciência ante a ausência de bases sólidas para seus anseios de felicidade e para suas representações simbólicas. Com esse propósito, toma como objeto de reflexão um dos ensaios filosóficos de Albert Camus, O mito de Sísifo, equacionando a possibilidade de uma ética que estilize a vida, sem que se minimize a dolorosa precariedade da existência humana. Posteriormente, em diálogo com alguns textos de M. Foucault, a reflexão procura estabelecer os vínculos possíveis entre a ética camusiana e a ética como uma estética da existência, tal como pensada entre os gregos antigos.

  20. Estrategia Internacional para la seguridad humana en los desastres naturales

    Directory of Open Access Journals (Sweden)

    Helena Torroja Mateu

    2016-01-01

    Full Text Available Este artículo presenta los rasgos principales de la estrategia internacional universal de seguridad humana en casos de desastres naturales liderada por la ONU. La estrategia se basa en dos grandes funciones: la prevención y preparación ante desastres naturales y la movilización y coordinación de la asistencia humanitaria a las víctimas, incluida la de los propios órganos operacionales de la ONU. Del desarrollo de ambas funciones se encargan diversos órganos operacionales (UNISDIR, PNUD, OCHA.... Con respecto a ambas finalidades se han adoptado directrices políticas y normativas por la Asamblea General. Destaca en este sentido el interés actual de la CDI, quien trabaja en un proyecto de artículos sobre la protección de personas en casos de desastres.

  1. O problema da natureza humana em Jacques Maritain

    Directory of Open Access Journals (Sweden)

    Névio de Campos

    2013-05-01

    Full Text Available Este artigo tem por objetivo discutir o problema da natureza humana em Jacques Maritain, destacando sua crítica ao humanismo antropocêntrico e a concepção do humanismo integral. Apoia-se na obra Humanismo Integral e nos debates da História Intelectual para problematizar a origem de seus escritos (contexto de produção e a acepção de humanismo teocêntrico (História da Filosofia proposta por esse filósofo tomista. Esta discussão permite-nos afirmar que o humanismo antropocêntrico é acusado por Maritain de conformar, nos tempos modernos, a própria tragédia do homem, da cultura e de Deus, assim como sustentar que o humanismo integral foi postulado como filosofia reintegradora da unidade ocidental, cindida pela filosofia naturalista (Renascimento/Reforma/Iluminismo/Comunismo.

  2. Prácticas de histología humana

    OpenAIRE

    Hilario Rodríguez, Enrique

    2010-01-01

    La Histología en su quehacer diario es una disciplina eminentemente práctica. La docencia de la Histología Humana se desarrolla básicamente a través de clases magistrales, seminarios y clases prácticas. Para la realización de estas últimas el alumno dispone de un microscopio óptico y diferentes preparaciones histológicas, así como de fotografías de microscopía electrónica. El programa práctico de la asignatura se desglosa a lo largo de veinticinco temas, que comienzan con la Histología Gen...

  3. Presencia de residuos y contaminantes en leche humana

    Directory of Open Access Journals (Sweden)

    Prado Flores Guadalupe

    2002-01-01

    Full Text Available La contaminación de la leche humana por xenobióticos es un problema generalizado a nivel mundial, que se ve afectado por las variaciones geográficas, climáticas, culturales y socioeconómicas de cada lugar. Las políticas de salud pública han enfrentado la situación mediante una vigilancia sostenida y legislaciones restrictivas con el objeto de reducir los efectos perjudiciales sobre las poblaciones y el ambiente, sin embargo se registran datos objetivables, sobre todo en los países en desarrollo. En esta revisión se destacan aspectos generales y particulares de los residuos y contaminantes organoclorados, organofosforados, antibióticos, metales pesados, bifenilos policlorados, dioxinas y furanos, valores de sus contenidos, efectos tóxicos estudiados y los límites máximos permitidos por las legislaciones internacionales.

  4. Notas sobre o autotelismo discursivo em ciências humanas

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo Lopes

    1994-12-01

    Full Text Available O Ateliê de Semiótica Discursiva, coordenado por Denis Bertrand, propôs focalizar, no ano letivo 1991-1992, a " Estética do Discurso Erudito", no quadro da temática "Estética da Ética" do Seminário de Semântica Geral, de A.J . Greimas, na Escola de Altos Estudos em Ciências Sociais de Paris (E. H. E. S. S.. Bertrand distribuiu cópias de trechos de textos célebres em ciências humanas (Lévi-Strauss, Deleuze e Guattari, Greimas, Barthes, Foucault e outros, sobre os quais os participantes deveriam realizar análises que tomassem como modelo, por exemplo, aquelas praticadas por Greimas e Landowski em lntroduction à L 'Analyse du Discours en Sciences Sociales ( 1979.

  5. PRESENCIA DE RESIDUOS Y CONTAMINANTES EN LECHE HUMANA

    Directory of Open Access Journals (Sweden)

    Guadalupe Prado Flores

    2002-01-01

    Full Text Available La contaminación de la leche humana por xenobióticos es un problema generalizado a nivel mundial, que se ve afectado por las variaciones geográficas, climáticas, culturales y socioeconómicas de cada lugar. Las políticas de salud pública han enfrentado la situación mediante una vigilancia sostenida y legislaciones restrictivas con el objeto de reducir los efectos perjudiciales sobre las poblaciones y el ambiente, sin embargo se registran datos objetivables, sobre todo en los países en desarrollo. En esta revisión se destacan aspectos generales y particulares de los residuos y contaminantes organoclorados, organofosforados, antibióticos, metales pesados, bifenilos policlorados, dioxinas y furanos, valores de sus contenidos, efectos tóxicos estudiados y los límites máximos permitidos por las legislaciones internacionales.

  6. Toxocariosis humana en pacientes con lesión ocular

    Directory of Open Access Journals (Sweden)

    Yrma Espinoza

    2003-12-01

    Full Text Available OBJETIVO: Estimar la prevalencia de toxocariosis humana en sujetos con sintomatología ocular sospechosa. MATERIAL Y MÉTODOS: Se estudió personas atendidas en servicios de Oftalmología de varios hospitales de Lima, quienes luego de la evaluación especializada presentaban síntomas y lesiones compatibles con toxocariosis intraocular. Se obtuvo muestras de sangre de cada participante y se realizó serología para Toxocara mediante la técnica de ELISA, así mismo recuento de leucocitos y fórmula diferencial. También se aplicó una encuesta epidemiológica para identificar conductas que pudieran asociarse a mayor riesgo de infección. RESULTADOS: Se estudió 45 personas, 19 varones y 26 mujeres; el 55,6% fue reactivo en la prueba de ELISA. No hubo diferencias en cuanto a sexo y el resultado de serología; entre los participantes de 15 y 44 años, se encontró 63% de reactivos. No se evidenció diferencias significativas con los factores epidemiológicos estudiados. Tampoco se observó asociación entre el hallazgo de eosinofilia y el resultado de la serología. CONCLUSIÓN: La infección humana por Toxocara es frecuente en sujetos clínicamente sospechosos y afecta principalmente a población en edad productiva, por lo que debería buscarse precozmente la infección para prevenir complicaciones.

  7. Educación centrada en valores y dignidad humana

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    María Teresa YUREN CAMAREN

    2009-11-01

    Full Text Available La imagen esperanzadora que perfilaron no pocos intelectuales, políticos, banqueros y empresarios a partir del término de la guerra fría, del supuesto «fin de las ideologías» y de la idea de la «aldea global» se desvaneció bajo los trazos que la realidad fue delineando como signos de una creciente tendencia a la barbarie que pone en peligro la vida en el plantea y que lesiona, de muchas maneras y en muchos rincones de la tierra, la dignidad humana3. Ante este panorama, se ha vuelto insistente la pregunta respecto de si los procesos educativos escolares pueden contribuir en algo para oponerse a esa tendencia. La respuesta positiva a esta interrogante se ha traducido en diversos esfuerzos para desarrollar lo que se ha llamado «educación valoral», o «educación centrada en valores, esfuerzos que si bien difieren en el signo teórico e ideológico y en el tipo de estrategia aplicada, han estimulado la interlocución, la reflexión y el estudio sobre el tema. El presente trabajo tiene la intención de contribuir a ese debate teórico al aportar algunos elementos que sustentan la tesis de que una educación escolar centrada en valores ha de ser un proceso eminentemente formativo que tenga como horizonte axiológico la dignidad humana.

  8. Quantitative Analysis of Serumβ-HCG in Patients with Ectopic Pregnancy%宫外孕患者血清β-HCG定量分析

    Institute of Scientific and Technical Information of China (English)

    陶春妃; 朱晓莉

    2016-01-01

    Objective By patients serumβ-HCG quantitative analysis is simple and effective method of early diagnosis of ectopic pregnancy.Methods using chemiluminescence method to detect the contents ofβ-HCG serum of 623 cases of ectopic pregnancy patients and 250 cases of normal pregnancy group ofβ-HCG levels and compare.Results 250 cases of normal pregnancy serumβ-HCG average concentration is 71.78 mIU/mL,623 cases of ectopic pregancy group serumβ-HCG average concentration of 37.49 mIU/mL.Ectopic pregnancy patients serumβ-HCG average concentration is lower than normal pregnancy;Ectopic pregnancy patients serum concentration ofβ-HCG on between 15mIU/mL to 45 mIU/mL.Conclusion Ectopic pregnancy patients serum beta HCG levels significantly lower than the control group ( ﹤0.05),β-HCG serum quantitative analysis has an important value for early diagnosis of ectopic pregnancy diagnosis,worth clinical promotion.%目的:通过患者血清β-HCG定量分析探讨早期诊断宫外孕的简便有效的方法。方法采用化学发光方法检测623例宫外孕患者血清β-HCG含量与250例正常妊娠组β-HCG含量并进行比较。结果250例正常妊娠组的血清β-HCG平均浓度为71.78 mIU/mL,623例宫外孕组的血清β-HCG平均浓度为37.49 mIU/mL。宫外孕患者的血清β-HCG平均浓度低于正常妊娠组;宫外孕患者血清β-HCG的浓度集中在15~45 mIU/mL。结论异位妊娠组患者血清β-HCG水平明显低于对照组(<0.05),对早期诊断宫外孕诊断具有重要的价值。

  9. A randomized controlled dose-response pilot study of addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization

    DEFF Research Database (Denmark)

    Loft, A; Egeberg, Anne Noes; Smitz, J;

    2012-01-01

    Is it possible to define an optimal dose of hCG in combination with rFSH from the first day of stimulation in the GnRH agonist protocol applied to IVF? SUMMARY ANSWER: Supplementation with hCG from the first day of stimulation may increase the number of top-quality embryos per patient. Daily doses...... of hCG up to 150 IU are compatible with good live birth rates. A ceiling level of estradiol (E(2)) was reached with hCG doses above 100 IU/day. A positive dose-response was seen for pre-ovulatory progesterone, but concentrations remained below values for which an impairment of endometrial receptivity...... has been previously reported. We suggest a large clinical trial to be proceeded with a group given 100 IU hCG daily versus a control group. WHAT IS KNOWN AND WHAT THIS PAPER ADDS: Prospective multicentre studies have indicated increased live birth rates and increased number of top-quality embryos when...

  10. Production of specific antisera for radioimmunoassay of human luteinizing hormone (LH) in the presence of human chorionic gonadotropin (hCG). [/sup 125/I

    Energy Technology Data Exchange (ETDEWEB)

    Thorell, J.I.; Jeppsson, S.; Holmstrom, B.

    1976-09-01

    A specific radioimmunoassay for LH, which measures plasma LH in the presence of human chorionic gonadotropin (hCG) is described. Rabbits were immunized with highly purified native LH. One of the antisera with a difference in its reactivity against LH and hCG was further purified by affinity chromatography on a column with hCG coupled to Sepharose 4B. The adsorbed antiserum and /sup 125/I-LH was used in a double antibody assay. The LH standard (MRC/68/40) efficiently inhibited the binding of /sup 125/I-LH, and the standard curve showed a sensitivity of 0.5 ng/ml in the sample. hCG up to 10,000 ng/ml did not inhibit the binding of /sup 125/I-LH. The plasma level of LH in pregnant women in the first trimester was low (1.3 +- 0.1 ng/ml). When LH was measured in fertile or menopausal women with or without stimulation with LH/FSH releasing hormone (LH-RH)/sup x/ the results agreed to those found with our conventional LH-assay based on antiserum against hCG.

  11. The effect of post-mating hCG or progesterone administration on reproductive performance of Afshari × Booroola-Merino crossbred ewes.

    Science.gov (United States)

    Rostami, Behnam; Hajizadeh, Rahman; Shahir, Mohammad-Hossein; Aliyari, Davood

    2017-02-01

    To investigate the efficiency of hCG/CIDR after breeding to increase the reproductive performance, 35 synchronized ewes were mated with fertile rams and were assigned to three treatment groups. Ewes in hCG group (n = 12) received 400 IU hCG on day 11 post-mating, and ewes in CIDR group (n = 11) received CIDR from day 7 until day 19 post-mating. Ewes in the control group (n = 12) did not receive any treatment. Blood samples were collected on days 7, 12, 17, and 22 post-mating. Plasma P4 concentrations were higher on days 12 and 17 post-mating in hCG- and CIDR-treated groups (P hCG and control groups were higher than that in CIDR group (P hCG group produced more quadruplets (P hCG group (3.6%) was less than that in control (11.8%; P  0.05) groups. Post-mating administration of hCG or CIDR did not affect the lamb birth weight in single and quadruplet births (P > 0.05), but the birth weight of twin lambs was higher in the hCG and CIDR groups (P hCG and CIDR groups (P hCG/CIDR administration post-mating increased the maternal P4 concentrations and enhanced reproductive performance.

  12. A study of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer after two or more implantation failures.

    Science.gov (United States)

    Huang, Pinxiu; Wei, Lihong; Li, Xinlin

    2017-01-01

    To investigate the effect of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer (FET) after two or more implantation failures (TIFs). The study was a prospective randomized single-blind study of 161 cycles in patients undergoing FET who had TIFs. The intervention group received an intrauterine injection of 1000 IU of hCG before embryo transfer (ET) (n = 62). A placebo group (n = 49) received an intrauterine injection of physiological saline before ET. A control group (n = 50) did not receive an intrauterine injection. Clinical pregnancy rates, abortion rates, and ongoing pregnancy rates were compared between the three groups. The clinical pregnancy rates were 59.68%, 53.06%, and 32.00% in the hCG group, placebo group, and control group, respectively. The clinical pregnancy rates were significantly higher in the hCG and placebo groups than in the control group. There were no significant differences in the abortion rates among the three groups. An intrauterine administration of hCG before FET significantly improved the pregnancy rates after TIFs. But local injury caused by the operation of intrauterine perfusion may play an important role in improving clinical pregnancy rates.

  13. Bio-equivalent doses of recombinant HCG and recombinant LH during ovarian stimulation result in similar oestradiol output: a randomized controlled study.

    Science.gov (United States)

    Alsbjerg, Birgit; Elbaek, Helle Olesen; Laursen, Rita Jakubcionyte; Povlsen, Betina Boel; Haahr, Thor; Yding Andersen, Claus; Humaidan, Peter

    2017-08-01

    In nature, HCG is secreted by the implanting embryo from peri-implantation and onwards. In contrast, LH is mandatory for steroidogenesis and follicular development during the follicular phase, working in synergy with FSH. Moreover, LH is mandatory for the function of the corpus luteum. Although LH and HCG bind to the same receptor, significant molecular, structural and functional differences exist, inducing differences in bioactivity. This randomized controlled study compared the effect of recombinant FSH stimulation combined with daily either micro-dose recombinant HCG or recombinant LH supplementation in a 1:1 bioactivity ratio from day 1 of stimulation in a long gonadotrophin releasing hormone agonist down regulation protocol. A total of 100 patients from a public clinic completed the study. The primary end-point was the oestradiol level on the day of ovulation trigger and the median oestradiol level in the HCG supplemented group was 8662 pmol/l versus 9203 pmol/l in the recombinant LH supplemented group; therefore, no significant difference was found. Moreover, no differences were observed in the number of oocytes retrieved or in the live birth rate. We conclude that recombinant HCG and recombinant LH are equally effective in boosting oestradiol synthesis during ovarian stimulation when used in a 1:1 bioactivity ratio. Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  14. Live birth of twins after performing early hCG administration as a modification of natural cycle in vitro fertilization, in a women with decreased ovarian reserve.

    Science.gov (United States)

    Hyman, Jordana H; Sokal-Arnon, Tamar; Son, Weon-Young; Tan, Seang Lin; Dahan, Michael H

    2015-01-01

    This case reports the first twin live births achieved in a woman with a serum FSH of such magnitude -80 IU/L, after following early hCG administration in natural cycle in vitro fertilization (IVF). Case report. A 27-year-old with 2 years of primary infertility presented with regular menses since menarche. FSH following clomiphene citrate challenge test was 80 IU/L. Antral follicle count was 1. After failing two IVF cycles, natural cycle IVF with early hCG administration was attempted. Ovulation with 10,000 IU hCG was triggered when the dominant follicle was 10 mm in mean diameter. Two smaller follicles were also present. Oocyte collection was performed 38 h after hCG injection. Three mature oocytes were retrieved. Two oocytes fertilized normally. Two good-quality embryos were transferred on day 2. Bichorionic biamniotic pregnancy was achieved and healthy twins were delivered at term. This case suggests that natural cycles with early hCG administration should be investigated further as an option for poor responders to retrieve more than one mature oocyte, and prevent premature ovulation. We believe this case to represent the patient with the highest serum FSH level, reflective of ovarian reserve at the time of treatment, to achieve a live birth. It is also the first case report to describe this modification on the traditional natural cycle.

  15. The clinical significance of preoperative serum CEA,β-HCG and CXs detection in the diagnosis of non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    Xian-Hua Yang; Juan Chen

    2016-01-01

    Objective:To study the clinical significance of preoperative serum CEA,β-HCG and CXs detection in the diagnosis of non-small cell lung cancer and provide reference for clinical diagnosis and disease treatment.Methods:Non-small cell lung cancer patients treated in our hospital from April 2009 to April 2014 were analyzed. Correlation between preoperative serum CEA,β-HCG as well as Cxs and clinical stages as well as prognosis of non-small cell lung cancer was assayed. Healthy subjects in our hospital during the same period were taken as control group.Results:Serum CEA,β-HCG and Cxs had no obvious correlation with patients’ age and gender, but CEA andβ-HCG had negative correlation with the clinical stages and prognosis of non-small cell lung cancer while Connexin43 had positive correlation with the clinical stages and prognosis of non-small cell lung cancer.Conclusions:Preoperative serum CEA combined withβ-HCG and CXs detection can be taken as key molecules in clinical diagnosis and prognosis of non-small cell lung cancer.

  16.  The Values of CA-125, Progesterone, ß-HCG and Estradiol in the Early Prediction of Ectopic Pregnancy

    Directory of Open Access Journals (Sweden)

    Hala Abdul Qadir Al-Moayed

    2012-03-01

    Full Text Available  Objective: To explore the diagnostic value and measurement of serum CA-125, the single measurement of progesterone (P,ß-HCG, and estradiol (E2 in the early diagnosis of ectopic pregnancy.Methods: Serum levels of CA-125, progesterone, ß-HCG and estradiol were measured by Enzyme Linked Immuno Sorbent Assay (ELISA techniques in 40 symptomatic women with ectopic pregnancy and 24 women with normal intrauterine pregnancy during gestational age of 4-10 weeks at Al-Kadhmiya Teaching Hospital, Baghdad, Iraq, between November 2010 and June 2011.Results: The mean ±SEM serum levels of CA-125, progesterone, ß-HCG, and estradiol in patients with ectopic pregnancies (16.51±2.39U/ml; 2.54±0.47ng/ml; 72.75±12.27mIU/ml; 13.4±2.14pg/ml; respectively were significantly lower than the levels in normal intrauterine pregnancies (74.25±18.5U/ml; 28.36±3.7ng/ml; 249.54±18.0mIU/ml; 112.7±23.6pg/ml; respectively. When using a CA-125 concentration of 20.5 U/ml as a cut-off value for the diagnosis of ectopic pregnancy, sensitivity was 75.7�20specificity 100�20the positive predictive value was100�0and the negative predictive value 71.4�onclusion: The measurement of CA-125 and progesterone levels is useful in discriminating ectopic from normal gestations.

  17. Intrauterine administration of hCG immediately after oocyte retrieval and the outcome of ICSI: a randomized controlled trial.

    Science.gov (United States)

    Navali, N; Gassemzadeh, A; Farzadi, L; Abdollahi, S; Nouri, M; Hamdi, K; Mallah, F; Jalilvand, F

    2016-11-01

    Does the intrauterine administration of hCG immediately after oocyte retrieval in antagonist cycles with ICSI and fresh embryo transfer (ET) influence the implantation rate or chemical and clinical pregnancy rates? The intrauterine administration of hCG after oocyte retrieval increases the implantation rate and chemical and clinical pregnancy rates. Over half of IVF/ICSI cycles fail due to implantation failure. Intrauterine administration of hCG, a few minutes before ET, increased the implantation and pregnancy rates in most but not in all studies. The effect of intrauterine administration of hCG, after oocyte retrieval, has not yet been studied. The study was a parallel, triple-blind randomized clinical trial (RCT) performed from September 2015 to February 2016, in a university hospital. We recruited women undergoing antagonist ovarian stimulation, ICSI and ET. For an effect size of 0.2, power of 80% at a significance level of 0.05, we needed 150 participants. Accounting for a 7% dropout rate, a total of 160 women was considered appropriate. A computer-generated randomization list with a block size of 4, with 1:1 allocation was used. The treatment allocation was placed in a sealed, opaque, envelope and picked up consecutively. Immediately after oocyte retrieval, patients in the intervention and control groups were treated with intrauterine injection of hCG and saline, respectively. Participants underwent ET on Day 3. A beta-hCG test was done at 2 weeks. If positive, three transvaginal-ultrasonographies (TVSs) were done at 3, 4 and 10 weeks after ET. The participants were called up thereafter and questioned about the continuity of their pregnancy. Of 1990 women attending the infertility clinic of our university hospital, 508 were IVF/ICSI candidates during the study period, and 245 of the patients on an antagonist cycle met the criteria to be invited into our trial. Inclusion criteria were normal ovarian reserve, age ≤41, undergoing ICSI, and fresh ET and normal

  18. Re-aproximaciones y posibles aplicaciones del concepto de seguridad humana

    OpenAIRE

    Waldimeiry Corrêa da Silva; Roberta Silva Machado

    2016-01-01

    Este artículo describe y analiza el concepto de seguridad humana en el ámbito de Naciones Unidas y de las Relaciones Internacionales y su relación con la doctrina de la Responsabilidad de proteger (R2P). Pretendemos responder a las siguientes preguntas: ¿La utilización de la doctrina de la Responsabilidad de proteger amplía el concepto de la seguridad humana o lo reduce a su dimensión vertical? ¿El concepto de seguridad humana contribuye a la comprensión y enfrenta...

  19. La "Dignitatis humanae" e la nuova laicità oltre la rivoluzione e la controrivoluzione

    OpenAIRE

    Alberti, V.V. (V.Vittorio)

    2012-01-01

    La declaración sobre la libertad religiosa, Dignitatis humanae, representa un paso importante tanto en la presentación de la libertad humana dentro de la Iglesia como en el campo político. Al consagrar la conciencia y la libertad religiosa como un bien supremo, Dignitatis humanae completa la reflexión de Gaudium et spes sobre la Iglesia en el mundo moderno. Se establece el cristianismo como una religión del Logos, del diálogo y de la búsqueda. En la actual era de la gl...

  20. Mujeres y dignidad humana. Antecedentes en el Sistema Interamericano y en el Derecho constitucional de Colombia

    Directory of Open Access Journals (Sweden)

    Viviana Bohórquez Monsalve

    2010-01-01

    Full Text Available El texto analiza la aplicación del derecho a la dignidad humana en casos relacionados con los derechos humanos de las mujeres. Primero se indaga por los principales instrumentos interamericanos que protegen la dignidad humana. Posteriormente se estudian los alcances y las limitaciones de los informes de la Comisión Interamericana y la jurisprudencia de la Corte Interamericana. En tercer lugar se presenta la postura de la Corte Constitucional de Colombia en casos de mujeres relacionados con los postulados internacionales. Finalmente, se presentan algunas conclusiones acerca del alcance y efectividad del derecho a la dignidad humana de las mujeres.

  1. Manifiesto por una reconfiguración de las ciencias humanas/sociales. una perspectiva vygotskyana

    OpenAIRE

    Bronckart, Jean Paul; Clémence, Alain; Schneuwly, Bernard; Schurmans, Marie Noëlle

    2010-01-01

    En este Manifiesto sostenemos que la metodología global de las ciencias humanas/sociales es del orden de la comprensión. Sobre el fondo del pre-conocimiento de la actividad humana de la cual participa, el investigador está siempre confrontado a la interpretación de acciones y de textos, a través de los cuales intenta leer las modalidades de organización de las representaciones humanas, y a través de las cuales intenta por consiguiente una mejor comprensión. Es entonces en este contexto global...

  2. hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells.

    Science.gov (United States)

    Tapia-Pizarro, Alejandro; Archiles, Sebastián; Argandoña, Felipe; Valencia, Cecilia; Zavaleta, Keyla; Cecilia Johnson, M; González-Ramos, Reinaldo; Devoto, Luigi

    2017-06-01

    How does hCG signal in human endometrial stromal cells (ESCs) and what is its role in regulating ESC function? hCG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) pathway through exchange protein activated by cyclic AMP (cAMP) (Epac) and transiently increases progesterone receptor (PR) transcript and protein expression and its transcriptional function. hCG is one of the earliest embryo-derived secreted signals in the endometrium, which abundantly expresses LH/hCG receptors. hCG signals through cAMP/protein kinase A (PKA) in gonadal cells, but in endometrial epithelial cells, hCG induces Erk1/2 activation independent of the cAMP/PKA pathway. Few data exist concerning the signal transduction pathways triggered by hCG in ESCs and their role in regulation of ESC function. This is an in vitro study comprising patients undergoing benign gynecological surgery (n = 46). Endometrial samples were collected from normal cycling women during the mid-secretory phase for ESCs isolation. The study conducted in an academic research laboratory within a tertiary-care hospital. The activation of the Erk1/2 signal transduction pathway elicited by hCG was evaluated in ESC. Signaling pathway inhibitors were used to examine the roles of PKA, PI3K, PKC, adenylyl cyclase and Epac on the hCG-stimulated up-regulation of phospho-Erk1/2 (pErk1/2). Erk1/2 phosphorylation was determined by immunoblot. siRNA targeting Epac was used to investigate the molecular mechanisms. To assess the role of Erk1/2 signaling induced by hCG on ESC function, gene expression regulation was examined by immunofluorescence and real-time quantitative PCR. The role of PR on the regulation of transcript levels was studied using progesterone and the PR antagonist RU486. All experiments were conducted using at least three different cell culture preparations in triplicate. Addition of hCG to ESCs in vitro induced the phosphorylation of Erk1/2 through cAMP accumulation. Such

  3. Comparative study between uses of GnRH- agonist versus hCG as an ovulation trigger in patients with polycystic ovary syndrome in antagonist protocol

    Directory of Open Access Journals (Sweden)

    Poornima Nadkarni

    2015-08-01

    Full Text Available Background: Polycystic ovary syndrome is one of the major causes of infertility. Almost 75% of ovulatory women have PCOS. Ovarian hyperstimulation syndrome and multiple pregnancies are known complications of PCOS in ART. Many studies are available now, to reduce the incidence and severity of OHSS in these patients, at the same time achieving acceptable pregnancy rate .In our study, we used Antagonist protocol in PCOS patients and compared the results using GnRH-Agonist versus hCG as ovulation trigger. Methods: This is double blinded comparative study between uses of GnRH- Agonist versus hCG as an ovulation trigger in 100 patients with polycystic ovary syndrome in antagonist protocol, done in private ART setting. In the study, 100 patients randomly allotted in two groups (A and B, each 50 patients, given ovulation trigger (When leading three follicles were >18 mm as group A-GnRH-Agonist (Inj. Triptoreline 0.1 mg, 12 hours apart two doses subcutaneously and group B hCG as (Inj. Recombinant hCG, 250 mcg single dose subcutaneously. Results: In our study, In 50 patients of group A, total 31 patients were pregnant. In group B of 50 cases, 29 patients were pregnant. There was no significant difference between two groups (P>0.05. Incidence of ovarian hyperstimulation syndrome is significantly less in PCOS patients, when GnRH agonist is used as ovulation trigger in Antagonist protocol, as compared to hCG (P 0.05. None patient of two groups developed severe OHSS. Conclusions: Incidence of the ovarian hyperstimulation syndrome is significantly less in patients with Polycystic Ovarian Syndrome when GnRH agonist is used as an ovulation trigger, as compared to hCG, in Antagonist protocol. In our study, there was no significant difference in pregnancy rates between two groups. [Int J Reprod Contracept Obstet Gynecol 2015; 4(4.000: 1161-1164

  4. Identification of patients with persistent trophoblastic disease after complete hydatidiform mole by using a normal 24-hour urine hCG regression curve.

    Science.gov (United States)

    van Cromvoirt, Suzanne M E; Thomas, Chris M G; Quinn, Michael A; McNally, Orla M; Bekkers, Ruud L M

    2014-06-01

    The aim of this study was to establish a reference 24-hour urine human chorionic gonadotropin (hCG) regression curve in patients with complete hydatidiform mole (CHM) as diagnostic tool in the prediction of persistent trophoblastic disease (PTD). From 2004 to 2011, 312 cases suitable for this study were registered at the Hydatidiform Mole Registry of the Royal Women's Hospital Melbourne, Australia. hCG levels of 61 patients diagnosed as having PTD according to FIGO 2000 criteria were compared with the 95th-percentile (p95) of the normal regression curve derived from hCG levels of 251 cases of uneventful CHM. In the test group of 61 patients PTD was diagnosed by FIGO 2000 criteria after a mean (±SD, min.-max.) of 7.6 (±3.4, 3.0-16.7) weeks after evacuation of the mole while in the same group hCG values for the first time exceeded the upper limit of the 95th percentile significantly earlier after 4.5 (±1.9, 2.0-9.9) weeks (PhCG levels of 14% of the cases of uneventful CHM at least once exceeded the upper limit of p95, showing that one single value above p95 is not accurate enough for the diagnosis of PTD. The normal 24-hour urine hCG regression curve may be used as a tool in the follow-up of an individual case of CHM after evacuation. At least one hCG level exceeding the upper limit of p95 within 11weeks after evacuation could be added to the current FIGO criteria, in order to diagnose PTD early, but the lack of it may also prevent unnecessary treatment. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Clinical significance of detecting CEA, CA199, AFP, HCG, CA153, CA125 in postoperative treatment of patients with ovarian cancer

    Institute of Scientific and Technical Information of China (English)

    Xue Pan; Zhen-Hua Du

    2016-01-01

    Objective:To explore the clinical significance of carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), a tire protein (AFP), human chorionic gonadotropin (HCG), carbohydrate antigen 153 (CA153) and carbohydrate antigen 125 (CA125) in the postoperative treatment of patients with ovarian cancer.Methods:210 cases of patients with ovarian cancer after initial treatment from January 2015 to December 2015, 232 cases of patients with ovarian benign tumor and 250 cases of healthy women were selected, CEA, CA199, AFP, HCG, CA153 and CA125 levels were detected, and the levels after chemotherapy in patients with ovarian carcinoma were detected.Results:CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer were (12.37±7.43) ng/mL, (84.04±26.96) U/mL, (37.46±9.47) μg/L, (110.54±35.51) IU/L, (51.23±9.20) U/mL and (64.36±42.68) U/mL, respectively, which were significantly higher than that in normal controls and patients with benign ovarian lesions, and were considered to be statistically significant. Chemotherapy after two cycles, CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer were significantly lower than that before chemotherapy, and were considered to be statistically different. Chemotherapy after four cycles, CEA, CA199, AFP, HCG, CA153 and CA125 levels in patients with ovarian cancer continue to decrease, and were significantly lower than that of chemotherapy after two cycles, and had statistical differences.Conclusion:CEA, CA199, AFP, HCG, CA153 and CA125 can be used as important indicators for monitoring the chemotherapy effects, early recurrence and metastasis of ovarian cancer.

  6. Retrospective comparison of GnRH agonist trigger with HCG trigger in GnRH antagonist cycles in anticipated high-responders.

    Science.gov (United States)

    Datta, Adrija Kumar; Eapen, Abey; Birch, Heidi; Kurinchi-Selvan, Anitha; Lockwood, Gillian

    2014-11-01

    All IVF-ICSI cycles carried out between October 2009 and October 2012 using GnRH agonist (GnRHa) ovulation trigger (n = 62) followed by a single dose of HCG plus progesterone and oestradiol in the luteal phase because of anticipated ovarian hypertsimulation were retrospectively compared with historic control cycles using HCG trigger (n = 29) and standard luteal phase support. Women's mean age, body mass index, anti-Müllerian hormone, FSH, LH, starting and total stimulation dose, number of follicles, oocytes, embryos, fertilization, implantation, polycystic ovary syndrome, ICSI, live birth and ongoing pregnancy rates per embryo transfer were similar (GnRHa 40.7% versus HCG 35.0%). For each started cycle, GnRHa resulted in 11.4% higher (statistically non-significant) live birth and ongoing pregnancy rate (OR 1.73, CI 0.64 to 4.69), with a similar difference for double-embryo transfers (OR 1.62, CI 0.44 to 6.38) and less need for freezing all embryos (9.7% versus 27.6%; P = 0.04). Incidence of mild-to-moderate OHSS was 16.2% with GnRHa trigger and 31.0% with HCG trigger) and no severe OHSS in the former. The addition of single low-dose HCG in the luteal phase after GnRHa trigger for suspected high-responders reduced the incidence of OHSS with good clinical outcomes, compared with HCG trigger. Copyright © 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  7. Determination of biological activity of gonadotropins hCG and FSH by Förster resonance energy transfer based biosensors.

    Science.gov (United States)

    Mazina, Olga; Allikalt, Anni; Tapanainen, Juha S; Salumets, Andres; Rinken, Ago

    2017-02-09

    Determination of biological activity of gonadotropin hormones is essential in reproductive medicine and pharmaceutical manufacturing of the hormonal preparations. The aim of the study was to adopt a G-protein coupled receptor (GPCR)-mediated signal transduction pathway based assay for quantification of biological activity of gonadotropins. We focussed on studying human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH), as these hormones are widely used in clinical practice. Receptor-specific changes in cellular cyclic adenosine monophosphate (cAMP, second messenger in GPCR signalling) were monitored by a Förster resonance energy transfer (FRET) biosensor protein (T)Epac(VV) in living cells upon activation of the relevant gonadotropin receptor. The BacMam gene delivery system was used for biosensor protein expression in target cells. In the developed assay only biologically active hormones initiated GPCR-mediated cellular signalling. High assay sensitivities were achieved for detection of hCG (limit of detection, LOD: 5 pM) and FSH (LOD: 100 pM). Even the small-scale conformational changes caused by thermal inactivation and reducing the biological activity of the hormones were registered. In conclusion, the proposed assay is suitable for quantification of biological activity of gonadotropins and is a good alternative to antibody- and animal-testing-based assays used in pharmaceutical industry and clinical research.

  8. The histopathological effects of superovulatory drugs GnRHα/PMSG/HCG on the endometrial tissues of rat

    Directory of Open Access Journals (Sweden)

    Parviz Bazzi

    2005-09-01

    Full Text Available Background: Using of stimulatory drugs such as: GnRHα/ PMSG/ HCG for induction of superovulation and harvesting more oocytes is very common during Assisted Reproductive Techniques (ART. Studies and experiences have recently shown that the rate of successful implantation in stimulatory cycles is less than natural cycles. Methods: The possible effects of above mentioned drugs on ultrastructures of endometrial tissues (Luminal epithelium was done by endometrial biopsies from female rats (N=30 which were under superovulaion treatment and from control rats with normal menstrual cycles (N=30. The specimens were processed for electronmicroscopic studies. Qualitative and quantitative (morphologic and morphometric studies were carried out on electronmicrographs. Morphological findings based on three structures namely: nuclear channel system (NCS, giant mitochondria (GM and glycogen vacuoles in addition to pinopode system and nuclear euchromatin were evaluated. Results: In morphology, luminal epithelium was more active and had more secretions in rats under superovulation compared with control group. Morphometric findings showed that in case group, volume fraction of nucleus RER, mitochondrium, glycogen to cell and euchromatin to nucleus had statistically significant difference. Conclusion: Superovulatory drugs GnRHα/PMSG/HCG have a negative effect on endometrial tissues at the time of implantation which may lead to low implantation rate.

  9. Determination of biological activity of gonadotropins hCG and FSH by Förster resonance energy transfer based biosensors

    Science.gov (United States)

    Mazina, Olga; Allikalt, Anni; Tapanainen, Juha S.; Salumets, Andres; Rinken, Ago

    2017-01-01

    Determination of biological activity of gonadotropin hormones is essential in reproductive medicine and pharmaceutical manufacturing of the hormonal preparations. The aim of the study was to adopt a G-protein coupled receptor (GPCR)-mediated signal transduction pathway based assay for quantification of biological activity of gonadotropins. We focussed on studying human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH), as these hormones are widely used in clinical practice. Receptor-specific changes in cellular cyclic adenosine monophosphate (cAMP, second messenger in GPCR signalling) were monitored by a Förster resonance energy transfer (FRET) biosensor protein TEpacVV in living cells upon activation of the relevant gonadotropin receptor. The BacMam gene delivery system was used for biosensor protein expression in target cells. In the developed assay only biologically active hormones initiated GPCR-mediated cellular signalling. High assay sensitivities were achieved for detection of hCG (limit of detection, LOD: 5 pM) and FSH (LOD: 100 pM). Even the small-scale conformational changes caused by thermal inactivation and reducing the biological activity of the hormones were registered. In conclusion, the proposed assay is suitable for quantification of biological activity of gonadotropins and is a good alternative to antibody- and animal-testing-based assays used in pharmaceutical industry and clinical research. PMID:28181555

  10. Androgen priming using aromatase inhibitor and hCG during early-follicular-phase GnRH antagonist down-regulation in modified antagonist protocols

    DEFF Research Database (Denmark)

    Løssl, Kristine; Andersen, A N; Loft, A;

    2006-01-01

    Temporary exposure of follicles to increased levels of androgens may enhance their sensitivity to FSH. The aim of this study was to increase the intraovarian androgen level using aromatase inhibitors and hCG before controlled ovarian stimulation (COH) and to test this concept clinically.......Temporary exposure of follicles to increased levels of androgens may enhance their sensitivity to FSH. The aim of this study was to increase the intraovarian androgen level using aromatase inhibitors and hCG before controlled ovarian stimulation (COH) and to test this concept clinically....

  11. Estudio psicométrico de la prueba figura humana

    Directory of Open Access Journals (Sweden)

    Marhilde Sánchez de Gallardo

    2012-05-01

    Full Text Available La investigación tuvo como objetivo determinar las propiedades psicométricas de la prueba proyectiva Test de la figura humana (Machover, 1976, administrada en la exploración aptitudinal de los aspirantes a cursar estudios en la mención orientación, una de las diez menciones de la carrera Educación, en La Universidad el Zulia, Venezuela. Se utilizaron como autores principales Cohen y Swerdlik (2006, Hogan (2004, Larsen y Buss (2005 y Shaughnessy, Zechmeister y Zechmeister (2007. La metodología fue descriptiva, de campo, diseño no experimental. La prueba se aplicó a 559 personas, 484 de sexo femenino y 75 de sexo masculino, con edades entre 17 a 47 años. El coeficiente de fiabilidad obtenido con el método de la división por mitades fue de 0,77 interpretado medio alto, lo cual indica que el test es fiable, es decir existe correlación entre las mitades y los ítemes de cada una de las partes de la prueba. La confiabilidad interobservadores, efectuada por tres evaluadores independientes, resultó en un coeficiente de 0.87 la cual se interpreta como alta. Para determinar la validez de la prueba se utilizó la de constructo, con el índice de consistencia interna, encontrándose un valor de 0,51, que indica poca relación entre los diferentes aspectos medidos por la prueba, lo cual demuestra heterogeneidad de estos elementos. Se construyó un baremo local y se obtuvieron las normas de interpretación para la población mencionada. Se concluye que el test de la figura humana tiene fiabilidad y validez, sus resultados son consistentes y el instrumento mide el constructo que se pretende medir, recomendándose la utilización de las normas obtenidas para la interpretación de resultados.

  12. Mid-trimester maternal serum AFP and hCG as markers of preterm and term adverse pregnancy outcomes.

    Science.gov (United States)

    Tancrède, Sabrina; Bujold, Emmanuel; Giguère, Yves; Renald, Marie-Hélène; Girouard, Joel; Forest, Jean-Claude

    2015-02-01

    Objectif : Évaluer les coefficients de prévision propres aux taux sériques d’alphafœtoprotéine (AFP) et de gonadotrophine chorionique (hCG) constatés au deuxième trimestre pour ce qui est des issues de grossesse indésirables à médiation placentaire (IGIMP) obtenues avant le terme et à terme. Méthodes : Nous avons tiré, d’une étude de cohorte prospective, des données concernant des femmes nullipares ayant connu une grossesse monofœtale exempte d’aneuploïdie ou d’anomalies fœtales mortelles. Nous avons comparé les taux sériques maternels d’AFP et de hCG (mesurés entre 13 et 17 semaines de gestation et exprimés sous forme de multiples de la médiane [MoM] en fonction de l’âge gestationnel) des femmes ayant connu une IGIMP (prééclampsie, retard de croissance intra-utérin, décès fœtal) avant le terme ou à terme à ceux des femmes qui n’en sont pas venues à connaître de telles complications. Résultats : Au sein d’un groupe de 3 466 femmes nullipares, les taux sériques maternels d’AFP et de hCG étaient connus dans 2 110 cas et 2 125 cas, respectivement. Les femmes qui ont connu une IGIMP avant le terme présentaient des valeurs de MoM pour ce qui est des taux sériques d’AFP (1,4 vs 1,1 MoM; P  2,0 MoM ait été associée à un risque accru d’IGIMP avant le terme (RR, 4,6; IC à 95 %, 2,3 - 9,1), elle n’exerçait aucun effet sur le risque d’IGIMP à terme (RR, 1,1; IC à 95 %, 0,7 - 1,7). La constatation d’un taux sérique maternel d’AFP > 2,0 MoM a également été associée à une hausse considérable du risque d’IGIMP avant le terme (RR, 3,9; IC à 95 %, 1,6 - 9,8); le risque d’IGIMP à terme (RR, 1,2; IC à 95 %, 0,6 - 2,3) n’en était toutefois pas affecté. Conclusion : Au sein de la population à l’étude, les taux sériques maternels d’AFP ou de hCG > 2,0 MoM ont entraîné une hausse du risque d’IGIMP avant le terme, mais n’ont pas exercé une influence sur le

  13. Patologia cardiovascular en pacientes con infeccion por el virus de inmunodeficiencia humana

    National Research Council Canada - National Science Library

    Valenzuela-Rodriguez, German

    2012-01-01

    La infeccion por el virus de inmunodeficiencia humana (VIH) estuvo asociada a un incremento de la morbimortalidad, dado que inducia un estado de inmunosupresion severa, la cual facilitaba la aparicion de infecciones oportunistas...

  14. El concepto de dignidad humana y la utopia realista de los derechos humanos

    National Research Council Canada - National Science Library

    Habermas, Jurgen

    2010-01-01

    En este articulo Habermas defiende la tesis que sostiene que siempre ha existido una conexion interna entre la nocion moral de dignidad humana y la concepcion juridica de los derechos humanos, aunque...

  15. La persona humana como relación en el orden del Origen

    OpenAIRE

    2012-01-01

    El objetivo del artículo es mostrar que la noción de persona humana significa relación en orden al Origen, es decir, a Dios. Tal relación no es una operación o actividad (accidente) propia de la esencia humana, sino constitutiva del acto de ser personal humano. ‘El hombre es persona’ equivale a ‘el hombre nace de Dios’.

  16. Dignidad humana y situaciones terminales Human dignity and terminal situations

    Directory of Open Access Journals (Sweden)

    J. Masiá

    2007-01-01

    Full Text Available No hay que confundir la dignidad con las condiciones indignas en que puede encontrarse una persona por circunstancias exteriores o por la enfermedad. La persona paciente en situación terminal tiene dignidad humana, que exige ser respetada, no por ser paciente terminal, sino simplemente por ser persona. Pero es cierto que en situaciones terminales puede verse particularmente amenazada la dignidad. Sin embargo, no se debe deducir del criterio de respetar la dignidad la conclusión de prolongar la vida biológica a toda costa, sino la de garantizar la mejor calidad del vivir durante el proceso de morir y de acompañar dignamente a la persona que se aproxima a la muerte ayudándole a asumirla.Dignity should not be confused with the unbecoming conditions that a person can find himself in due to external situations or disease. The person/patient in a terminal situation has human dignity, which must be respected not because he/she is a terminal patient but simply because he/she is a person. But it is true that in terminal situations dignity can be particularly threatened. Nonetheless, one must not deduce from the criterion of respecting dignity the conclusion of prolonging biological life at all costs, but instead that of guaranteeing the best quality of living during the process of dying and of worthily accompanying the person who is approaching death by helping him to accept this.

  17. El significado del éxito reproductivo en poblaciones humanas

    Directory of Open Access Journals (Sweden)

    Crognier, Emile

    2003-01-01

    Full Text Available Para la sociobióloga, el éxito reproductivo a sido desde el principio, la medida universal del valor adaptivo. La noción es muy discutible, considerando que se trata de una estimación individual, inapropiada a evaluar el valor selectivo de un (supuesto genotipo, pero a pesar de su inadecuación y de la simplificación de su evaluación en la mayoridad de los estudios, el éxito reproductivo permanezco una medida muy popular. En el caso de las poblaciones humanas, su medida tuvo que ser aun más simplificada para tomar en cuenta la larga extinción de las generaciones, hasta ser el número de descendientes sobreviviendo hasta madurez sexual. Sin embargo, su definición aun no logro de ser ni precisa ni satisfactoria y los últimos trabajos parecen indicar que así como el coeficiente de consanguinidad, su significado se revela en la profundidad de la sucesión de las generaciones. Se discuta este tema, apoyándose en datos de grupos Beraber de Marueccos y Aymara de Bolivia

  18. El zinc, micronutriente importante en la salud humana

    Directory of Open Access Journals (Sweden)

    Alicia Velázquez Pérez

    2014-08-01

    Full Text Available La importancia biológica del zinc fue admitida por primera vez hace más de un siglo y en la actualidad continúan los estudios que avalan su valor en la nutrición humana. Se ha comprobado que la falta de zinc es bastante frecuente en la población de los países en vías de desarrollo, sobre todo en edades pediátricas, y se asocia en general a malnutrición y deficiencias de otros micronutrientes. El diagnóstico de la deficiencia leve de zinc en el hombre es difícil, ya que produce muchos síntomas clínicos inespecíficos. Por todo ello se realizó una revisión bibliográfica, para contribuir a incrementar los conocimientos del personal médico sobre su importancia, alimentos donde se puede encontrar, patologías en las que más está indicado su uso en pediatría y la forma de administración

  19. Toxocariosis humana: ¿problema de salud pública?

    Directory of Open Access Journals (Sweden)

    Pedro Huapaya H

    2009-12-01

    Full Text Available Se realizó una revisión bibliográfica para actualizar y sistematizar la información existente sobre la infección humana por el género Toxocara. Se describe los mecanismos de transmisión, epidemiología, formas clínicas, métodos de diagnóstico, esquemas de tratamiento. Además, se resalta su importancia como causa infecciosa de ceguera, en población joven, que resulta potencialmente prevenible y curable mediante el diagnóstico precoz. Por lo cual, se plantea propuestas para implementar la vigilancia epidemiológica. Asimismo, algunas sugerencias para mejorar la legislación existente que permita disminuir el riesgo de la transmisión a la población en general e incrementar el conocimiento que existe sobre esta infección en nuestro país.

  20. Conectividade: limitações humanas no uso de emails

    Directory of Open Access Journals (Sweden)

    Antonio Mendes Silva Filho

    2009-12-01

    Full Text Available Hoje vivenciamos o que costumo denominar de era da conectividade. Trata-se de um momento da história humana onde a comunicação tem sido muito exercitada por uma quantidade cada vez mais crescente de usuários da Internet. A conectividade propiciada pela Internet tem servido e muito ao que denomino de propulsor dos três C’s que compreendem comunicação, colaboração e compartilhamento como discutido em outros artigos [1], [2], [3], [4], [5] e [6]. Embora os usuários tenham usado cada vez mais a Internet para os três C’s, comunicação é uma arte vez e esta requer atenção e habilidade por parte dos usuários da Internet. Nesse sentido este artigo discute aspectos da comunicação influenciados pelo uso da Internet.

  1. Nuestra esencia: la condición humana

    Directory of Open Access Journals (Sweden)

    Bertilio Neri

    2004-01-01

    Full Text Available El nuevo paradigma del conocimiento está asociado a la intersubjetividad, la trans disciplina y la complejidad. La comprensión e interpretación de los procesos y fenómenos de la realidad, es posible si se atiende a la trama discursiva en la que se genera la contextualidad que da forma y contenido a las formas cognitivas de la razón, a partir de la diversidad, incertidumbre y las contradicciones. Se está en presencia de una reforma radical del pensamiento y de las instituciones, en todos sus órdenes y saberes. La universidad, debe responder a este reto creando las condiciones históricas para reformar el pensamiento, apren diendo de otro modo a saber pensar desde la crítica liberadora y el diálogo con las otras disciplinas y culturas. Los estudios de doctorado deben recoger en sus pensa y programas de investigación el nuevo rol de la epis te me en la construcción de un científico social más comprometido con su condición humana y ciudadana.

  2. Altas tecnologías, conflictos armados y seguridad humana

    Directory of Open Access Journals (Sweden)

    Elena del Mar García Rico

    2016-01-01

    Full Text Available El examen de las amenazas para la seguridad y el bienestar de las personas inherentes al concepto de seguridad humana exige ocuparse también de las consecuencias que la utilización de las altas tecnologías puedan ocasionar en relación con los conflictos armados actuales. De ahí que en este trabajo abordemos los cambios relevantes en la naturaleza y características de los nuevos conflictos armados provocados por la celeridad y amplitud en el empleo de altas tecnologías y su desigual distribución entre los beligerantes, tal y como muestran las llamadas guerras de coste cero, de cuarta generación o asimétricas, e incluso las híbridas. Asimismo, el desarrollo reciente de las capacidades militares cibernéticas, de los sistemas de armas autónomos y de los vehículos aéreos no tripulados plantea nuevos retos al Derecho Internacional Humanitario, aspectos contemplados en este estudio.

  3. CIENCIAS HUMANAS Y EMERGENCIA DE LA EDAD DIGITAL

    Directory of Open Access Journals (Sweden)

    Fischer, Hervé

    2013-06-01

    Full Text Available Estamos pasando de la era del fuego a la era digital, o sea, de la era de la energía, que incluye el fuego, el viento, el agua, la electricidad y la energía nuclear, a la era de la información. Pasamos así del binomio energía-materia a un nuevo paradigma epistemológico e instrumental, el de una codificación binaria y de una programación algorítmica con las cuales pretendemos reinterpretar el universo e instrumentarlo con una nueva potencia humana superior a la de las leyes habituales de la naturaleza. El hombre ha escogido marcar con su sello nuestra evolución y hablamos aquí de lo antropoceno. McLuhan fue el último gran pensador de la era del fuego, de los medios de difusión eléctricos; pero no podría ser el nuevo gurú de la era digital. La energía destruye le información. Lo digital la crea y la difunde.

  4. Re-aproximaciones y posibles aplicaciones del concepto de seguridad humana

    Directory of Open Access Journals (Sweden)

    Waldimeiry Corrêa da Silva

    2016-01-01

    Full Text Available Este artículo describe y analiza el concepto de seguridad humana en el ámbito de Naciones Unidas y de las Relaciones Internacionales y su relación con la doctrina de la Responsabilidad de proteger (R2P. Pretendemos responder a las siguientes preguntas: ¿La utilización de la doctrina de la Responsabilidad de proteger amplía el concepto de la seguridad humana o lo reduce a su dimensión vertical? ¿El concepto de seguridad humana contribuye a la comprensión y enfrentamiento a la Trata de Personas (la Trata? Con miras a contestar estas preguntas, el artículo está estructurado en tres partes: en la primera parte, presentamos el marco teórico- conceptual de la seguridad humana con base en los documentos de Naciones Unidas y la teoría de las relaciones internacionales; en la segunda, desde la noción de la R2P, su contenido y práctica internacional, observamos su contribución para el concepto de seguridad humana; en la tercera, utilizamos el enfoque de la seguridad humana para una comprensión global de la Trata.

  5. Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial

    DEFF Research Database (Denmark)

    Lossl, K; Andersen, C Yding; Loft, A;

    2008-01-01

    Temporary exposure of follicles to increased levels of androgens may augment follicular responsiveness. The present study tested whether short-term androgen priming by aromatase inhibitor and human chorionic gonadotrophin (hCG) before controlled ovarian stimulation (COS) increases the number of top...

  6. The effect of treatment with flunixin meglumine at different times relative to hCG administration on ovulation failure and luteal function in mares.

    Science.gov (United States)

    Cuervo-Arango, J

    2011-08-01

    Flunixin meglumine (FM), a prostaglandin synthetase inhibitor, causes ovulatory failure in the mare. However, the effect of the FM treatment relative to the time of hCG administration on the ovulation failure has not been determined nor has its effect on the luteal function of treated mares. Estrous mares with a follicle ≥32 mm (range of 32-38 mm) were treated with 1.7 mg/kg b.w. of FM iv at zero, 12, 24 and 36 h (n=6), at 24 and 36 h (n=6), at 28 and 36 h (n=6), at 24h (n=6) or at 30 h (n=6) after treatment with 1500 IU hCG. One group received no FM (control, n=6). Progesterone concentrations were determined using RIA. Mares treated with FM 0-36 h and 24-36 h had higher (P2 ng/ml). The progesterone concentration was lower in mares treated with FM at zero to 36 h and at 24-36 h after hCG than in the other groups. In conclusion, the FM administration was effective in blocking ovulation only when the treatment began ≤24 h after hCG and was continued every 12 h until ≥36 h. In addition, the FM-induced anovulatory follicles underwent luteinization of follicular cells with active production of progesterone. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Androgen priming using aromatase inhibitor and hCG during early-follicular-phase GnRH antagonist down-regulation in modified antagonist protocols

    DEFF Research Database (Denmark)

    Løssl, Kristine; Andersen, A N; Loft, A;

    2006-01-01

    Temporary exposure of follicles to increased levels of androgens may enhance their sensitivity to FSH. The aim of this study was to increase the intraovarian androgen level using aromatase inhibitors and hCG before controlled ovarian stimulation (COH) and to test this concept clinically....

  8. Progreso en el conocimiento de la microbiota intestinal humana

    Directory of Open Access Journals (Sweden)

    Virginia Robles-Alonso

    2013-06-01

    Full Text Available La aparición de nuevas técnicas de secuenciación así como el desarrollo de herramientas bioinformáticas han permitido no sólo describir la composición de la comunidad bacteriana que habita el tracto gastrointestinal, sino también las funciones metabólicas de las que proveen al huésped. La mayoría de los miembros de esta amplia comunidad bacteriana pertenecen a Dominio Bacteria, aunque encontramos también Archaea y formas eucariotas y virus. Únicamente entre 7 y 9 de las 55 Phyla del Dominio Bacteria conocidos están presentes en flora fecal humana. Su mayoría pertenecen además a las Divisiones Bacteroidetes and Firmicutes, encontrando también Proteobacteria, Actinobacteria, Fusobacteria y Verrucomicrobia. Bacteroides, Faecalibacterium y Bifidobacterium son los Géneros más abundantes aunque su abundancia relativa es muy variable entre individuos. El análisis metagenómico de la flora intestinal ha permitido describir una colección de 5 millones de genes microbianos que codifican para aproximadamente 20.000 funciones biológicas relacionadas con la vida de las bacterias. El ecosistema intestinal humano puede clasificarse en torno a tres grupos de acuerdo a la abundancia relativa de tres Géneros: Bacteroides (enterotipo 1, Prevotella (enterotipo 2 y Ruminococcus (enterotype 3. Estos grupos han sido denominados "enterotipos" y su descripción sugiere que las variaciones entre individuos están estratificadas. Una vez descrita la composición bacteriana sería interesante establecer la relación entre la alteración de equilibrios ecológicos con estados de enfermedad que puedan desembocar en una novedosa vía terapéutica.

  9. Alojamiento conjunto madre-hijo y lactancia humana exclusiva

    Directory of Open Access Journals (Sweden)

    FLORES-HUERTA SAMUEL

    1997-01-01

    Full Text Available Objetivo. Conocer la influencia del alojamiento conjunto (AC madre-hijo, en la frecuencia de lactancia humana exclusiva (LHE, desde el nacimiento hasta los cuatro meses de vida. Material y métodos. Estudio de cohortes no aleatorizado realizado en la clínica de lactancia del Hospital "Luis Castelazo Ayala", del Instituto Mexicano del Seguro Social, de enero de 1993 a octubre de 1994, en el que participaron 178 binomios madre-hijo (BMH sanos con gestación de término. El grupo con alojamiento conjunto (AC se integró con 90 BMH, y la madre recibió asesoría para lactar; 88 se atendieron en forma separada, sin asesoría para lactar. Se realizó análisis estadístico de los datos para apreciar frecuencia y asociaciones de las variables. Resultados. La alimentación se registró como LHE, fórmula o ambas. Los grupos con y sin AC se estratificaron por la forma de nacimiento, parto o cesárea. Con X² de Mantel-Haenszel y de rango logarítmico se aceptaron diferencias con p< 0.05. Durante el estudio la lactancia global fue semejante entre los grupos. En el primer mes la LHE fue mayor en el grupo con AC, 61 vs 42%, independientemente de la forma de nacimiento (p< 0.05. El AC fue la única variable que influyó para que se diera LHE. Conclusiones. El AC madre-hijo favorece la LHE en el primer mes posnacimiento.

  10. Indicadores de Criatividade no Desenho da Figura Humana

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    Karina da Silva Oliveira

    Full Text Available Resumo O objetivo deste estudo foi investigar evidências de precisão e de validade para um protocolo de análise de características criativas presentes no Desenho da Figura Humana (DFH. Para isso, realizaram-se dois estudos. A amostra foi composta por cinco juízes e 208 crianças de escolas públicas e particulares, com idades entre nove anos e 11 anos e 11 meses. O primeiro estudo referiu-se à precisão do protocolo, e o instrumento foi considerado adequado segundo os critérios de 75% de concordância e análise de Correlação de Pearson. Para o segundo estudo foram utilizados dois instrumentos, sendo um o protocolo de triagem criativa para o DFH e o Teste de Criatividade Figural Infantil. Os instrumentos foram comparados por meio de Correlação de Pearson e Análise Fatorial. Os resultados apontaram que indicadores tais como Elaboração, Expressão de Emoção e Movimento estão relacionados à características criativas no DFH. Foram observadas influências das variáveis tipo de escola e sexo para os itens de criatividade como movimento, perspectiva incomum e uso de contextos. Conclui-se que o protocolo de triagem criativa do DFH pode apresentar indicadores válidos de criatividade.

  11. Tratamiento contra la rabia humana: un poco de su historia

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    Maria Cristina Schneider

    1994-12-01

    Full Text Available El presente trabajo es una revisión histórica del tratamiento utilizado contra la rabia humana, desde la antigüedad hasta el momento actual. Pretende hacer una analogía entre el concepto de causa predominante en la época y el tipo de tratamiento utilizado. Los griegos antiguos tenían la diosa Artemisa como sanadora de la rabia y ya utilizaban la cauterización de la herida. Los pueblos del siglo I conocían la capacidad infecciosa en la saliva de perros rabiosos, llamando a ese material de veneno virus (en latín. En la Edad Media, cuando prevalecía un concepto mágico y religioso de la salud, el gran protector era San Humberto. Con el Renacimiento surgen nuevamente muchos experimentos y avances en el conocimiento de la enfermedad, que sentaron las bases para los importantes hallazgos en el futuro próximo. En esa época predominaba la teoría miasmática y del contagio. Pasteur fue un grande opositor de la espontaneidad de la rabia. A finales del siglo XIX, con los descubrimientos microbianos, Pasteur hizo la gran revolución científica en relación al tratamiento contra la rabia, que es la vacuna. Las vacunas pueden actualmente ser de tipo nervioso o no, variando también el numero de dosis recomendadas. Se han desarrollado muchos estudios sobre vacunas, siendo la más utilizada en América Latina del tipo Fuenzalida y Palacios, y la recomendada actualmente por la OMS es la de cultivo celular.

  12. Tratamiento contra la rabia humana: un poco de su historia

    Directory of Open Access Journals (Sweden)

    Schneider Maria Cristina

    1994-01-01

    Full Text Available El presente trabajo es una revisión histórica del tratamiento utilizado contra la rabia humana, desde la antigüedad hasta el momento actual. Pretende hacer una analogía entre el concepto de causa predominante en la época y el tipo de tratamiento utilizado. Los griegos antiguos tenían la diosa Artemisa como sanadora de la rabia y ya utilizaban la cauterización de la herida. Los pueblos del siglo I conocían la capacidad infecciosa en la saliva de perros rabiosos, llamando a ese material de veneno virus (en latín. En la Edad Media, cuando prevalecía un concepto mágico y religioso de la salud, el gran protector era San Humberto. Con el Renacimiento surgen nuevamente muchos experimentos y avances en el conocimiento de la enfermedad, que sentaron las bases para los importantes hallazgos en el futuro próximo. En esa época predominaba la teoría miasmática y del contagio. Pasteur fue un grande opositor de la espontaneidad de la rabia. A finales del siglo XIX, con los descubrimientos microbianos, Pasteur hizo la gran revolución científica en relación al tratamiento contra la rabia, que es la vacuna. Las vacunas pueden actualmente ser de tipo nervioso o no, variando también el numero de dosis recomendadas. Se han desarrollado muchos estudios sobre vacunas, siendo la más utilizada en América Latina del tipo Fuenzalida y Palacios, y la recomendada actualmente por la OMS es la de cultivo celular.

  13. A randomized controlled dose-response pilot study of addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization.

    Science.gov (United States)

    Thuesen, L L; Loft, A; Egeberg, A N; Smitz, J; Petersen, J H; Andersen, A Nyboe

    2012-10-01

    Is it possible to define an optimal dose of hCG in combination with rFSH from the first day of stimulation in the GnRH agonist protocol applied to IVF? Supplementation with hCG from the first day of stimulation may increase the number of top-quality embryos per patient. Daily doses of hCG up to 150 IU are compatible with good live birth rates. A ceiling level of estradiol (E(2)) was reached with hCG doses above 100 IU/day. A positive dose-response was seen for pre-ovulatory progesterone, but concentrations remained below values for which an impairment of endometrial receptivity has been previously reported. We suggest a large clinical trial to be proceeded with a group given 100 IU hCG daily versus a control group. Prospective multicentre studies have indicated increased live birth rates and increased number of top-quality embryos when low doses of hCG were associated with FSH. We analysed the clinical, embryological and endocrine aspects of adding increasing doses of hCG to rFSH from the first day of stimulation for IVF. A prospective randomized, controlled, open-label dose-response pilot study was conducted between February 2009 and June 2010 at Copenhagen University Hospital, Rigshospitalet, Denmark. Adequate allocation concealment was assured from sequentially numbered, opaque, sealed envelopes prepared from a computer-generated list. Scoring of the embryos was done in an assessor-blinded way. Endocrinologically normal IVF patients aged 25-37 years, BMI 18-30 kg/m(2), regular cycles and FSH D100; n= 16) and Dose 150 (D150; n= 15). Two patients in D150 were withdrawn after randomization because of major (10- to 30-fold) hCG dosing errors, leaving 13 patients in this group. Thus, the results are based on the per protocol population. The mean numbers of top-quality embryos per patient were D0: 0.8 ± 1.2, D50: 0.5 ± 0.7, D100: 1.2 ± 1.7 and D150: 1.5 ± 1.7 (P= 0.04). All pregnancies were singleton gestations, and the live birth rates per started cycle were D0

  14. Significance of pregnancy test false negative results due to elevated levels of β-core fragment hCG.

    Science.gov (United States)

    Johnson, Sarah; Eapen, Saji; Smith, Peter; Warren, Graham; Zinaman, Michael

    2017-01-01

    Very high levels of β-core fragment human chorionic gonadotrophin (βcf-hCG) are reported to potentially cause false negative results in point-of-care (POC)/over-the-counter (OTC) pregnancy tests. To investigate this further, women's daily early morning urine samples, collected prior to conception and during pregnancy, were analysed for intact, free β-, and βcf-hCG. The proportion of βcf-hCG was found to be related to that of hCG produced and in circulation. Therefore, best practice for accuracy testing of POC/OTC pregnancy tests would be to test devices against clinical samples containing high levels of βcf-hCG as well as standards spiked with biologically relevant ratios.

  15. Association between serum estradiol level on the hCG administration day and IVF-ICSI outcome

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    Tayfun Kutlu

    2012-01-01

    Full Text Available Background: Estradiol (E2 is required for follicular development and play an important role in embryo implantation. Objective: The aim of this study was to assess the impact of serum E2 levels on the day of hCG administration in IVF-ICSI patients who are performed controlled ovarian hyperstimulation (COH.Materials and Methods: A total of 203 women who were undergone one time IVF cyclus were evaluated in this cross sectional study. All the patients were treated either with long protocol or with microdose flare protocol. The patients were categorized into five groups according to the serum E2 levels on the day of hCG administration.Results: The mean number of the retrieved oocytes was (NRO 10.6±6.7, mean fertilization rate was 55.7±24.8, and implantation rate was 9.0±19.2. Of 203 patients, 43 (21% patients were pregnant. When the overall results are examined, the number of the retrieved oocytes and the number of transferred embryos were better in patients with serum E2 levels >4000 pg/ml and these values were statistically significant. There were no statistical difference in patients 37 years or older. In women ≤36 years old, the IVF-ICSI outcomes were better in patients with serum E2 levels >4000 pg/ml.Conclusion: In spite of the lack of high quality evidence to support a positive association between serum E2 levels and IVF-ICSI outcomes, this study shows that high E2 levels during COH might be associated with an increased potential of pregnancy depending on better ovarian response. When the overall results are examined, the best scores were in patients with serum E2 levels >4000 pg/ml.

  16. Evidence for azimuthal variations of the oxygen-abundance gradient tracing the spiral structure of the galaxy HCG 91c

    Science.gov (United States)

    Vogt, F. P. A.; Pérez, E.; Dopita, M. A.; Verdes-Montenegro, L.; Borthakur, S.

    2017-05-01

    Context. The distribution of elements in galaxies forms an important diagnostic tool to characterize these systems' formation and evolution. This tool is, however, complex to use in practice, as galaxies are subject to a range of simultaneous physical processes active from pc to kpc scales. This renders observations of the full optical extent of galaxies down to sub-kpc scales essential. Aims: Using the WiFeS integral field spectrograph, we previously detected abrupt and localized variations in the gas-phase oxygen abundance of the spiral galaxy HCG 91c. Here, we follow-up on these observations to map HCG 91c's disk out to 2 Re at a resolution of 600 pc, and characterize the non-radial variations of the gas-phase oxygen abundance in the system. Methods: We obtained deep MUSE observations of the target under 0.6 arcsec seeing conditions. We perform both a spaxel-based and aperture-based analysis of the data to map the spatial variations of 12 +log (O/H) across the disk of the galaxy. Results: We confirm the presence of rapid variations of the oxygen abundance across the entire extent of the galaxy previously detected with WiFeS, for all azimuths and radii. The variations can be separated in two categories: a) localized and associated with individual H ii regions; and b) extended over kpc scales, and occurring at the boundaries of the spiral structures in the galaxy. Conclusions: Our MUSE observations suggest that the enrichment of the interstellar medium in HGC 91c has proceeded preferentially along spiral structures, and less efficiently across them. Our dataset highlights the importance of distinguishing individual star-forming regions down to scales of a few 100 pc when using integral field spectrographs to spatially resolve the distribution of oxygen abundances in a given system, and accurately characterize azimuthal variations and intrinsic scatter. The movie associated to Fig. 8 is available at http://www.aanda.org

  17. Cross-talk between cAMP and MAPK pathways in HSD11B2 induction by hCG in placental trophoblasts.

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    Qun Shu

    Full Text Available Overexposure of the fetus to glucocorticoids in gestation is detrimental to fetal development. The passage of maternal glucocorticoids into the fetal circulation is governed by 11beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11B2 in the placental syncytiotrophoblasts. Human chorionic gonadotropin (hCG plays an important role in maintaining placental HSD11B2 expression via activation of the cAMP pathway. In this study, we investigated the relationship between the activation of the cAMP pathway by hCG and subsequent phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2 or p38 mitogen-activated protein kinase (MAPK pathways in the regulation of placental HSD11B2 expression in human placental syncytiotrophoblasts. We found that treatment of the placental syncytiotrophoblasts with either hCG or dibutyl cAMP (dbcAMP could promote the phosphorylation of p38 and ERK1/2. Inhibition of p38 MAPK with SB203580 not only reduced the basal HSD11B2 mRNA and protein levels but also attenuated HSD11B2 levels induced by either hCG or dbcAMP. By contrast, inhibition of ERK1/2 with PD98059 increased the basal mRNA and protein levels of HSD11B2 and had no effect on HSD11B2 mRNA and protein levels induced by either hCG or dbcAMP. These data suggest that p38 MAPK is involved in both basal and hCG/cAMP-induced expression of HSD11B2, and ERK1/2 may play a role opposite to p38 MAPK at least in the basal expression of HSD11B2 in human placental syncytiotrophoblasts and that there is complicated cross-talk between hCG/cAMP and MAPK cascades in the regulation of placental HSD11B2 expression.

  18. The steroid response to human chorionic gonadotropin (hCG) stimulation in men with Klinefelter syndrome does not change using immunoassay or mass spectrometry.

    Science.gov (United States)

    Roli, L; Santi, D; Belli, S; Tagliavini, S; Cavalieri, S; De Santis, M C; Baraldi, E; Fanelli, F; Mezzullo, M; Granata, A R; Pagotto, U; Pasquali, R; Rochira, V; Carani, C; Simoni, M; Trenti, T

    2017-08-01

    Liquid-chromatography tandem mass-spectrometry (LC-MS/MS) was developed in parallel to Immunoassays (IAs) and today is proposed as the "gold standard" for steroid assays. Leydig cells of men with Klinefelter syndrome (KS) are able to respond to human chorionic gonadotropin (hCG) stimulation, even if testosterone (T) production was impaired. The aim was to evaluate how results obtained by IAs and LC-MS/MS can differently impact on the outcome of a clinical research on gonadal steroidogenesis after hCG stimulation. A longitudinal, prospective, case-control clinical trial. (clinicaltrial.gov NCT02788136) was carried out, enrolling KS men and healthy age-matched controls, stimulated by hCG administration. Serum steroids were evaluated at baseline and for 5 days after intramuscular injection of 5000 IU hCG using both IAs and LC-MS/MS. 13 KS patients (36 ± 9 years) not receiving T replacement therapy and 14 controls (32 ± 8 years) were enrolled. T, progesterone, cortisol, 17-hydroxy-progesterone (17OHP) and androstenedione, were significantly higher using IAs than LC-MS/MS. IAs and LC-MS/MS showed direct correlation for all five steroids, although the constant overestimation detected by IAs. Either methodology found the same 17OHP and T increasing profile after hCG stimulation, with equal areas under the curves (AUCs). Although a linearity between IA and LC-MS/MS is demonstrated, LC-MS/MS is more sensitive and accurate, whereas IA shows a constant overestimation of sex steroid levels. This result suggests the need of reference intervals built on the specific assay. This fundamental difference between these two methodologies opens a deep reconsideration of what is needed to improve the accuracy of steroid hormone assays.

  19. Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro.

    Science.gov (United States)

    Riccetti, Laura; De Pascali, Francesco; Gilioli, Lisa; Potì, Francesco; Giva, Lavinia Beatrice; Marino, Marco; Tagliavini, Simonetta; Trenti, Tommaso; Fanelli, Flaminia; Mezzullo, Marco; Pagotto, Uberto; Simoni, Manuela; Casarini, Livio

    2017-01-05

    Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) are glycoprotein hormones regulating development and reproductive functions by acting on the same receptor (LHCGR). We compared the LH and hCG activity in gonadal cells from male mouse in vitro, i.e. primary Leydig cells, which is a common tool used for gonadotropin bioassay. Murine Leydig cells are naturally expressing the murine LH receptor (mLhr), which binds human LH/hCG. Cultured Leydig cells were treated by increasing doses of recombinant LH and hCG, and cell signaling, gene expression and steroid synthesis were evaluated. We found that hCG is about 10-fold more potent than LH in cAMP recruitment, and slightly but significantly more potent on cAMP-dependent Erk1/2 phosphorylation. However, no significant differences occur between LH and hCG treatments, measured as activation of downstream signals, such as Creb phosphorylation, Stard1 gene expression and testosterone synthesis. These data demonstrate that the responses to human LH/hCG are only quantitatively and not qualitatively different in murine cells, at least in terms of cAMP and Erk1/2 activation, and equal in activating downstream steroidogenic events. This is at odds with what we previously described in human primary granulosa cells, where LHCGR mediates a different pattern of signaling cascades, depending on the natural ligand. This finding is relevant for gonadotropin quantification used in the official pharmacopoeia, which are based on murine, in vivo bioassay and rely on the evaluation of long-term, testosterone-dependent effects mediated by rodent receptor.

  20. Impact of buserelin acetate or hCG administration on day 5 post-ovulation on subsequent luteal profile and conception rate in Murrah buffalo (Bubalus bubalis).

    Science.gov (United States)

    Pandey, A K; Dhaliwal, G S; Ghuman, S P S; Agarwal, S K

    2015-11-01

    The present study aimed to establish the impact of buserelin acetate or hCG administration on day 5 post-ovulation on subsequent luteal profile and conception rate in buffalo. The buffalo (n=45) were subjected to an estrous synchronization protocol (synthetic analog of PGF2α administered, through intramuscular route, 11 days apart), followed by artificial insemination (AI) during mid to late estrus. On day 5 post-ovulation, buffalo were administered (i.m.) normal saline (Control, n=14), buserelin acetate (20μg, d5-BA, n=14) or human chorionic gonadotropin (3000IU, d5-hCG, n=17). Ovarian ultrasonography was conducted on the day of induced estrus and on days 0, 5, 12, 16 and 21 post-ovulation to assess preovulatory follicle or corpus luteum (CL) diameter. Also, on these days, jugular vein blood sampling was conducted for the estimation of plasma progesterone. First service conception rate was greater (χ(2)=5.18, P>0.05) in d5-BA and d5-hCG groups (71.4% and 47.1%, respectively) as compared to control (28.6%). Both treatment groups had a greater (Ppost-treatment period in comparison to that control treatment group. Treatment-induced accessory CL formation was observed in 92.9% and 76.5% buffalo of d5-BA and d5-hCG groups, respectively. In conclusion, buserelin acetate and hCG administration on day 5 post-ovulation leads to accessory CL formation that may have a role in enhancing conception rate.

  1. Timing of human chorionic gonadotropin (hCG) hormone administration in IVF/ICSI protocols using GnRH agonist or antagonists: a systematic review and meta-analysis.

    Science.gov (United States)

    Chen, Ying; Zhang, Yi; Hu, Min; Liu, Xiru; Qi, Hongbo

    2014-06-01

    To evaluate the effect of altering the timing of human chorionic gonadotropin (hCG) administration on the clinical outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) using gonadotropic hormone releasing hormone (GnRH) agonist or antagonist. We systematically searched six databases. Randomized controlled trials (RCTs) of the effects of altering the timing of hCG administration on the clinical outcome of IVF and ICSI using GnRH agonist or antagonist were included. A meta-analysis was conducted following a quality evaluation performed with Cochrane Collaboration's Review Manager (RevMan) 5.0.2. Seven RCTs and a total of 1295 participants were included. Significant difference was observed regarding estradiol and progesterone levels on the day of hCG administration and oocyte retrieval between early hCG and late hCG administration group and in favor of the latter. The fertilization rate was not statistically different between early and 24-h late hCG groups, but it is significantly higher in the 48-h late hCG group. The pooled results showed no significant differences in the ongoing pregnancy rate per oocyte pick-up, the miscarriage rate and the live birth rate. The prolongation of follicular phase by delaying hCG administration could increase estradiol, progesterone levels and oocyte retrieval, which will not influence ongoing pregnancy rate per oocyte pick-up, miscarriage rate and live birth rate. Postponing hCG may enable increased flexibility of cycle scheduling to avoid weekend procedures.

  2. Adiaspiromicose humana. Relato de um caso tratado com cetoconazol

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    Ricardo Luiz M. Martins

    1997-12-01

    Full Text Available É descrito um caso de adiaspiromicose humana, da forma pulmonar disseminada, no qual se empregou o cetoconazol. O paciente, oriundo de Goianésia, GO, referia tosse produtiva, dispnéia e emagrecimento. Doente há dois meses, já fizera uso do esquema tríplice tuberculostático, devido a um radiograma do tórax ter acusado lesões sugestivas de tuberculose miliar. Esse tratamento não surtiu o efeito esperado, pelo que foi ele submetido a uma biópsia pulmonar a céu aberto. A medida permitiu o reconhecimento da natureza fúngica da doença. Passou-se, então, ao emprego do cetoconazol, quando o processo já completara três meses de evolução. Dois meses depois, foi o paciente novamente visto, para controle do tratamento: todas as manifestações respiratórias haviam cessado e um novo radiograma mostrou regressão completa das alterações pulmonares. Apesar disso, é discutida a eficácia do cetoconazol contra C. parvum var crescens, tendo-se em conta o fato de o microrganismo não se reproduzir no hospedeiro.A case of human disseminated pulmonary adiaspiromycosis is reported. The patient, from Goianesia, GO, was admitted to the Brasilia University Hospital, in November 1992, with wet cough, dyspnea and weight loss3/4manifestations that had appeared two months before. Prior to admission, he had been treated for a suspected miliary tuberculosis, because a chest roentgenogram had shown a diffuse reticulonodular infiltrate in both lungs. This therapy brought no improvement to the patient status. An open chest biopsy was then performed, and the microscopic examination of the lung tissue revealed the fungal nature of the disease. Ketoconazole, 400mg/day, was started and the patient discharged from the hospital. He was seen again two months later: the respiratory manifestations had disappeared and a new chest roentgenogram showed complete resolution of the pulmonary lesions. The usefulness of ketoconazole is, however, questioned, since, as there

  3. La consultoría de gestión humana en empresas medianas1

    Directory of Open Access Journals (Sweden)

    Esteban López Zapata

    2010-01-01

    Full Text Available El artículo es resultado de una investigación que busca describir el mercado de la consultoría de gestión humana para empresas medianas de Medellín. Se identifican el concepto y las características de la consultoría gerencial y se plantea su pertinencia para cada proceso de gestión humana. Con una muestra de 57 empresas medianas y 19 empresas consultoras, se analiza el comportamiento de la demanda y la oferta en el contexto local. Se identifican los atributos de las empresas demandantes y sus dependencias de gestión humana, la composición de las empresas consultoras, las necesidades y ofertas de consultoría actuales y futuras, el proceso de compra y las dificultades frecuentes de los proyectos de consultoría.

  4. Fundamentos filosóficos de la dignidad humana y su incidencia en los derechos humanos

    OpenAIRE

    Torres Bardales, Coloníbol

    2015-01-01

    El ser humano tiene dos vidas. Una física y otra humana. Ambas son diferentes pero están íntimamente relacionadas. La vida humana no es biológica, no es la persona de carne y huesos; no son los músculos ni la masa encefálica, ni los demás órganos que le dan existencia física. Su origen se encuentra en la organización de la sociedad, en las instituciones sociales, y entre ellas, la familia es clave fundamental. La dignidad humana es el epicentro de la constitución política del Estado, base fil...

  5. LA GERENCIA DEL TALENTO HUMANO BAJO LA PERSPECTIVA DE LA CONDICIÓN HUMANA

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    OMAR CABRALES SALAZAR

    2009-01-01

    Full Text Available El artículo destaca la importancia de los atributos de la condición humana y del desarrollo del potencial humano en la optimización de las competencias de los gerentes de hoy. Se plantea que con el propósito de mejorar la gestión del talento humano y poder comprender y gestionar mejor a su equipo de trabajo, el gerente debe conocer cuáles son los atributos de la condición humana y cómo desarrollar las competencias para trabajarlos con optimismo, de manera tal que implemente estrategias para la mejora del talento de su gente. En este marco el talento se observa como una variable inagotable y susceptible de permanente desarrollo. El documento concluye haciendo un llamado al reconocimiento de la condición humana en las organizaciones, como estrategia necesaria para afrontar las inequidades de la sociedad actual.

  6. LA CONSULTORÍA DE GESTIÓN HUMANA EN EMPRESAS MEDIANAS

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    ESTEBAN LÓPEZ ZAPATA

    2010-01-01

    Full Text Available El artículo es resultado de una investigación que busca describir el mercado de la consultoría de gestión humana para empresas medianas de Medellín. Se identifi can el concepto y las características de la consultoría gerencial y se plantea su pertinencia para cada proceso de gestión humana. Con una muestra de 57 empresas medianas y 19 empresas consultoras, se analiza el comportamiento de la demanda y la oferta en el contexto local. Se identifi can los atributos de las empresas demandantes y sus dependencias de gestión humana, la composición de las empresas consultoras, las necesidades y ofertas de consultoría actuales y futuras, el proceso de compra y las difi cultades frecuentes de los proyectos de consultoría.

  7. Daily low-dose hCG stimulation during the luteal phase combined with GnRHa triggered IVF cycles without exogenous progesterone: a proof of concept trial.

    Science.gov (United States)

    Andersen, Claus Yding; Elbaek, Helle Olesen; Alsbjerg, Birgit; Laursen, Rita Jakubcionyte; Povlsen, Betina Boel; Thomsen, Lise; Humaidan, Peter

    2015-10-01

    Can the luteal phase support be improved in terms of efficacy, hormonal profiles and convenience as compared with today's standard care? Daily low-dose rhCG supplementation in GnRHa triggered IVF cycles can replace the traditional used luteal phase support with exogenous progesterone. A bolus of hCG for final maturation of follicles in connection with COS may induce the risk of OHSS and the luteal phase progesterone levels rise very abruptly in the early luteal phase. This is a proof-of-concept study conducted as a three arm RCT with a total of 93 patients. First patient enrolled in January 2012 and the study finished in January 2014. Normal responder women undergoing IVF/ICSI treatment in a university hospital. One arm served as control, where women followed a standard antagonist protocol. Two study arms were included both having 125 IU hCG daily for luteal phase support without exogenous progesterone after using a GnRHa trigger for ovulation induction. In both study arms exogenous FSH was stopped on stimulation day 6 and replaced by exogenous hCG that was initiated on either stimulation day 2 or day 6. Blood samples were obtained on the day of ovulation induction, on the day of oocyte pickup (OPU) and day OPU + 7. The mean serum levels of hCG did not exceeded the normal physiological range of LH activity in any samples. Mid-luteal progesterone levels were significantly higher in the two study groups receiving daily low-dose hCG for luteal phase support as compared with the control group (control group: 177 ± 27 nmol/l; study group 1: 334 ± 42 nmol/l; study group 2: 277 ± 27 nmol/l; (mean ± SEM). No differences in reproductive outcome were seen between groups. The number of patients included is limited and conclusions need to be verified in a larger RCT. Endogenous production of progesterone may become more attractive as the luteal phase support with levels of LH-like activity only in the physiological range and may, from the patients' point of view, replace

  8. A randomized double-blinded controlled trial of hCG as luteal phase support in natural cycle frozen embryo transfer.

    Science.gov (United States)

    Lee, Vivian Chi Yan; Li, Raymond Hang Wun; Yeung, William Shu Biu; Pak Chung, H O; Ng, Ernest Hung Yu

    2017-05-01

    Does the use of hCG as luteal phase support in natural cycle frozen embryo transfer (FET) increase the ongoing pregnancy rate? The use of hCG in natural cycle FET did not improve the ongoing pregnancy rate. The use of luteal phase support in stimulated cycles has been associated with higher live-birth rates and the results are similar when using hCG or progesterone. This is a randomized double-blinded controlled trial of 450 women recruited between August 2013 and October 2015. Women with regular cycles undergoing natural cycle FET were recruited. Serial serum hormonal concentrations were used to time natural ovulation and at least Day 2 cleavage embryos were replaced. Patients were randomized into either: (i) the treatment group, receiving 1500 IU hCG on the day of FET and 6 days after FET, or (ii) the control group, receiving normal saline on these 2 days. The ongoing pregnancy rate [60/225 (26.7%) in the treatment group vs 70/225 (31.3%) in the control group, odds ratio 1.242 (95% CI 0.825-1.869)], implantation rate and miscarriage rate were comparable between the two groups. In the treatment group, there were significantly more cycles with top quality embryos transferred and a significantly higher serum oestradiol level, but a comparable serum progesterone level, 6 days after FET. However, no significant differences were observed in serum oestradiol and progesterone levels 6 days after FET between the pregnant and non-pregnant women. In the multivariate logistic regression, the number of embryos transferred was the only significant factor predictive of the ongoing pregnancy rate after natural cycle FET. This study only included FET with cleavage stage embryos and only hCG, not vaginal progesterone, was used as luteal phase support. The findings in this study do not support the use of hCG for luteal phase support in natural cycle FET. No external funding was used and there were no competing interests. clinicaltrial.gov identifier: NCT01931384. 23/8/2013. 30/8/2013.

  9. An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism.

    Science.gov (United States)

    Nieschlag, Eberhard; Bouloux, Pierre-Marc G; Stegmann, Barbara J; Shankar, R Ravi; Guan, Yanfen; Tzontcheva, Anjela; McCrary Sisk, Christine; Behre, Hermann M

    2017-03-07

    Hypogonadotropic hypogonadism (HH) in men results in insufficient testicular function and deficiencies in testosterone and spermatogenesis. Combinations of human chorionic gonadotropin (hCG) and recombinant follicle-stimulating hormone (recFSH) have been successful in the treatment of HH. Corifollitropin alfa is a long-acting FSH-analog with demonstrated action in women seeking infertility care. The aim of this study was to investigate the efficacy and safety of corifollitropin alfa combined with hCG to increase testicular volume and induce spermatogenesis in men with HH. This was a Phase III, multi-center, open-label, single-arm trial of corifollitropin alfa in azoospermic men aged 18 to 50 years with HH. After 16 weeks of pretreatment of 23 subjects with hCG alone, 18 subjects with normalized testosterone (T) levels who remained azoospermic entered the 52-week combined treatment phase with hCG twice-weekly and 150 μg corifollitropin alfa every other week. The increase in testicular volume (primary efficacy endpoint) and induction of spermatogenesis resulting in a sperm count ≥1 × 10(6)/mL (key secondary efficacy endpoint) during 52 weeks of combined treatment were assessed. Safety was evaluated by the presence of anti-corifollitropin alfa antibodies and the occurrence of adverse events (AEs). Mean (±SD) testicular volume increased from 8.6 (±6.09) mL to 17.8 (±8.93) mL (geometric mean fold increase, 2.30 [95% CI: 2.03, 2.62]); 14 (77.8%) subjects reached a sperm count ≥1 × 10(6)/mL. No subject developed confirmed anti-corifollitropin alfa antibodies during the trial. Treatment was generally well tolerated. Corifollitropin alfa 150 μg administrated every other week combined with twice-weekly hCG for 52 weeks increased testicular volume significantly, and induced spermatogenesis in >75% of men with HH who had remained azoospermic after hCG treatment alone. ClinicalTrials.gov: NCT01709331 .

  10. Maternal plasma levels of cell-free β-HCG mRNA as a prenatal diagnostic indicator of placenta accrete.

    Science.gov (United States)

    Zhou, J; Li, J; Yan, P; Ye, Y H; Peng, W; Wang, S; Wang, X Tong

    2014-09-01

    Several biomarkers, including maternal serum creatinine kinase and α-fetoprotein, have been described as potential tools for the diagnosis of placental abnormalities. This study aimed to determine whether maternal plasma mRNA levels of the β subunit of human chorionic gonadotropin (β-HCG) could predict placenta accreta prenatally. Sixty-eight singleton pregnant women with prior cesarean deliveries (CDs) were classified into three groups: normal placentation (35 women, control group); placenta previa alone (21 women, placenta previa group); and both placenta previa and placenta accreta (12 women, placenta previa/accreta group). Maternal plasma concentrations of cell-free β-HCG mRNA were measured by real-time reverse-transcription polymerase chain reaction and were expressed as multiples of the median (MoM). Cell-free β-HCG mRNA concentrations (MoM, range) were significantly higher in women with placenta accreta (3.65, 2.78-7.19) than in women with placenta previa (0.94, 0.00-2.97) or normal placentation (1.00, 0.00-2.69) (Steel-Dwass test, P placenta previa/accreta group, the concentration of cell-free β-HCG mRNA was significantly higher among women who underwent CDs with hysterectomy (4.41, 3.49-7.19) than among women whose CDs did not result in hysterectomy (3.20, 2.78-3.70) (Mann-Whitney U test, P = 0.012). An increased level of cell-free β-HCG mRNA in the maternal plasma of women with placenta accreta may arise from direct uteroplacental transfer of cell-free placental mRNA molecules. The concentration of cell-free β-HCG mRNA in maternal plasma may be applicable to the prenatal diagnosis of placenta accreta, especially to identify women with placenta accreta likely to require hysterectomy. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Reconocimiento alogénico: su papel protector durante la infección por el virus de la inmunodeficiencia humana tipo1 (VIH-1

    Directory of Open Access Journals (Sweden)

    María Teresa Rugeles López

    2004-03-01

    Full Text Available

    Varios estudios han señalado la importancia de la respuesta alogénica en la protección a la infección por el VIH-1; inclusive, se ha propuesto la aloinmunización como una vacuna profiláctica (1. Sin embargo, la evidencia más fuerte de que el aloreconocimiento contribuye a la protección contra la infección con el VIH-1 es aportada por un estudio de transmisión perinatal realizado en Nairobi. En este estudio la transmisión vertical se correlacionó con el grado de concordancia entre los alelos del CMH clase I entre la madre y el bebé: el máximo grado de concordancia se asoció con un 31% de incidencia de transmisión, mientras que la infección ocurrió solo en un 3% de niños que tenían el máximo grado de disparidad con su madre (2. La incidencia de la transmisión vertical del VIH-1 es del 25-30% en ausencia de terapia antirretroviral (3. El hecho de que el 70-75% de recién nacidos no nazca infectado, a pesar de haber estado expuesto en forma continua al virus, sugiere la existencia de barreras protectoras que previenen la transmisión vertical durante la gestación y el parto. Aunque existen reportes de inmunidad celular neonatal específica anti VIH-(4, otros mecanismos deben contribuir a la protección del feto y a prevenir la transmisión vertical. Recientemente, se reportó que factores solubles que se encuentran en la placenta, importantes para la implantación y el desarrollo del embrión, inhiben la replicación del VIH-1 in vitro.

    Entre estos factores se destacan: el factor inhibidor de leucemias (LIF (5, la hormona gonadotropina coriónica humana (hCG (6 y el factor derivado de células estromales tipo 1 (SDF-1 (7. Adicionalmente, en 1996 se describió la producción in vitro de un factor soluble que se genera en cultivos mixtos de linfocitos (CML conocido como ASF (8

  12. MUROS ABSURDOS E CONDIÇÃO HUMANA NA OBRA DE ALBERT CAMUS

    Directory of Open Access Journals (Sweden)

    Patrícia Oliveira Machado

    2015-04-01

    Full Text Available Albert Camus descreve a condição humana como sendo contingente, frágil e absurda, para isso ele utiliza a noção de “muros absurdos”, que são situações que enfrentamos e contra as quais não podemos escapar. Se a princípio, a morte, a velhice, a desumanidade parecem experiências banais, no pensamento camusiano, elas se revelam como possibilidade de tomada de consciência do absurdo de nossa condição. Palavras-chave: absurdo; condição humana; consciência.

  13. La familia, experiencia humana y sacramento de salvación

    OpenAIRE

    Corpas de Posada, Isabel

    2015-01-01

    Más que una categoría socioantropológica, la familia es una experiencia humana fundamentada en la calidad de las relaciones entre sus miembros, que se abre a la trascendencia y es capaz de transignificar, es decir, ser signo e instrumento del amor y la salvación de Dios. La intención del presente artículo es abordar la dimensión personal y social de la experiencia humana de familia, al mismo tiempo que su dimensión sacramental y eclesial como sacramento de salvación, a las cuales corresponden...

  14. Reflexões Bioéticas Sobre Sexualidade e Reprodução Humana

    OpenAIRE

    José Eduardo Siqueira

    2007-01-01

    Los avances producidos por los modernos métodos de control de la natalidad y de la fertilización humana asistida introdujeron en la reflexión ética nuevos valores como dignidad personal,autonomia y paternidad responsable. Loa antíguos preceptos de sumisión a la moralidad heterogénea de la Ley Natural fueronsustituidos por una ética de reflexión autónoma en los campos de la sexualidad y reproducción humana asistida.

  15. El discernimiento ético de la pareja humana. Un don, una tarea

    OpenAIRE

    Botero, José Silvio

    2010-01-01

    "El discernimiento ético de la pareja humana, un don, una tarea” es una reflexión dirigida a las parejas en vista a a ayudarles a tomar conciencia de su capacidad de discernimiento y de responsabilidad de frente a los conflictos que las ‘antinomias’ de la existencia humana (ley-libertad, doctrina-vida, norma-situación concreta) les plantean a diario. La enseñanza del post-Concilio Vaticano II reconoce a las parejas de esposos la capacidad de discernir y decidir siguiendo el dictamen de la con...

  16. Reflexões Bioéticas Sobre Sexualidade e Reprodução Humana

    OpenAIRE

    José Eduardo de Siqueira

    2007-01-01

    Los avances producidos por los modernos métodos de control de la natalidad y de la fertilización humana asistida introdujeron en la reflexión ética nuevos valores como dignidad personal,autonomia y paternidad responsable. Loa antíguos preceptos de sumisión a la moralidad heterogénea de la Ley Natural fueronsustituidos por una ética de reflexión autónoma en los campos de la sexualidad y reproducción humana asistida.

  17. Estudo correlacional entre o Teste de Pfister e o Desenho da Figura Humana

    OpenAIRE

    Cardoso,Lucila Moraes; Capitão,Cláudio Garcia

    2006-01-01

    Este estudo teve como objetivo buscar as correlações existentes entre os indicadores emocionais e cognitivos das Pirâmides Coloridas de Pfister e do Desenho da Figura Humana, tanto no sistema DFH-Koppitz como no DFH-Sisto. As técnicas das Pirâmides Coloridas de Pfister (TPC) e do Desenho da Figura Humana (DFH) são instrumentos projetivos que permitem que se conheçam aspectos da personalidade de quem os executa. De acordo com a literatura, os dois métodos medem o mesmo construto, justificando ...

  18. Buenas prácticas de manufactura en Bancos de Leche Humana de la Red Nacional de Bancos de Leche Humana de Guatemala

    Directory of Open Access Journals (Sweden)

    Evany Guzmán

    2017-03-01

    Full Text Available La presente investigación tuvo como objetivo verificar el cumplimiento de las Buenas Prácticas de Manufactura (BPM en siete Bancos de Leche Humana (BLH de la Red Nacional, estableciendo las condiciones y recomendaciones de infraestructura, equipos, procesos, procedimientos y personal para el mejoramiento de los BLH con el fin de asegurar su adecuado funcionamiento. Se realizó una auditoría diagnóstica evaluando las condiciones de BPM en los BLH de la Red Nacional utilizando la ficha de inspección de BPM del Reglamento Técnico Centroamericano (RTCA 67.01.33:06. La información recolectada se analizó mediante estadística descriptiva calculando un valor sobre 100 puntos, con el fin de valorar las condiciones y realizar un informe donde se detallaron las deficiencias y recomendaciones para mejorar el sistema y garantizar leche humana inocua, que fue entregado a cada BLH evaluado. Los BLH del Hospital General San Juan de Dios (HGSJD y del Hospital Regional de Antigua Guatemala obtuvieron punteos que indica que poseen buenas condiciones y son aptas para procesar la leche humana; los BLH del Hospital Regional de Cobán y Puerto Barrios con regulares condiciones con correcciones para el proceso con riesgo de contaminación; los BLH de Santa Rosa y Totonicapán con condiciones ineficientes que urge corregir y el BLH de Zacapa obtuvo punteo que indica condiciones inaceptables que sugieren considerar el cierre. La mayoría de BLH posee deficiencias claras, sin embargo, son aptos para procesar la leche humana con resultados inocuos con excepción del BLH de Zacapa.

  19. 人绒毛膜促性腺激素诱发排卵的优缺点%Advantage and disadvantage of hCG trigger

    Institute of Scientific and Technical Information of China (English)

    马文红; 梁晓燕

    2012-01-01

    The midcycle surge of luteinizing hormone (LH) is absolutely required for final maturation of the oocyte, initiation of follicular rupture and corpus luteum function. Human chorionic gonadotrophin (hCG) or GnRH analogue (GnRH-a) is used for final oocyte maturation in assisted conception cycles. Which one is used usually depends on controlled ovarian stimulation (COS) protocol with different hypothalamus-pituitary condition. hCG trigger induces better luteum function, pregnancy rate, hut higher ovarian hyperstimulation syndrome (OHSS). GnRH-a causes lower OHSS with impaired pregnant and miscarriage rate, which could he improved hy intensity luteum supply. We do not recommend that GnRH agonists are routinely used as a final oocyte maturation trigger in fresh autologous cycles because of lowered ongoing pregnancy and live hirth rates. An exception could he made for women with high risk of OHSS.

  20. Estrogen Modulates Specific Life and Death Signals Induced by LH and hCG in Human Primary Granulosa Cells In Vitro.

    Science.gov (United States)

    Casarini, Livio; Riccetti, Laura; De Pascali, Francesco; Gilioli, Lisa; Marino, Marco; Vecchi, Eugenia; Morini, Daria; Nicoli, Alessia; La Sala, Giovanni Battista; Simoni, Manuela

    2017-04-28

    Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are glycoprotein hormones used for assisted reproduction acting on the same receptor (LHCGR) and mediating different intracellular signaling. We evaluated the pro- and anti-apoptotic effect of 100 pM LH or hCG, in the presence or in the absence of 200 pg/mL 17β-estradiol, in long-term, serum-starved human primary granulosa cells (hGLC) and a transfected granulosa cell line overexpressing LHCGR (hGL5/LHCGR). To this purpose, phospho-extracellular-regulated kinase 1/2 (pERK1/2), protein kinase B (pAKT), cAMP-responsive element binding protein (pCREB) activation and procaspase 3 cleavage were evaluated over three days by Western blotting, along with the expression of target genes by real-time PCR and cell viability by colorimetric assay. We found that LH induced predominant pERK1/2 and pAKT activation STARD1, CCND2 and anti-apoptotic XIAP gene expression, while hCG mediated more potent CREB phosphorylation, expression of CYP19A1 and procaspase 3 cleavage than LH. Cell treatment by LH is accompanied by increased (serum-starved) cell viability, while hCG decreased the number of viable cells. The hCG-specific, pro-apoptotic effect was blocked by a physiological dose of 17β-estradiol, resulting in pAKT activation, lack of procaspase 3 cleavage and increased cell viability. These results confirm that relatively high levels of steroidogenic pathway activation are linked to pro-apoptotic signals in vitro, which may be counteracted by other factors, i.e., estrogens.

  1. A Positive Feedback Loop between Glial Cells Missing 1 and Human Chorionic Gonadotropin (hCG) Regulates Placental hCGβ Expression and Cell Differentiation

    Science.gov (United States)

    Cheong, Mei-Leng; Wang, Liang-Jie; Chuang, Pei-Yun; Chang, Ching-Wen; Lee, Yun-Shien; Lo, Hsiao-Fan; Tsai, Ming-Song

    2015-01-01

    Human chorionic gonadotropin (hCG) is composed of a common α subunit and a placenta-specific β subunit. Importantly, hCG is highly expressed in the differentiated and multinucleated syncytiotrophoblast, which is formed via trophoblast cell fusion and stimulated by cyclic AMP (cAMP). Although the ubiquitous activating protein 2 (AP2) transcription factors TFAP2A and TFAP2C may regulate hCGβ expression, it remains unclear how cAMP stimulates placenta-specific hCGβ gene expression and trophoblastic differentiation. Here we demonstrated that the placental transcription factor glial cells missing 1 (GCM1) binds to a highly conserved promoter region in all six hCGβ paralogues by chromatin immunoprecipitation-on-chip (ChIP-chip) analyses. We further showed that cAMP stimulates GCM1 and the CBP coactivator to activate the hCGβ promoter through a GCM1-binding site (GBS1), which also constitutes a previously identified AP2 site. Given that TFAP2C may compete with GCM1 for GBS1, cAMP enhances the association between the hCGβ promoter and GCM1 but not TFAP2C. Indeed, the hCG-cAMP-protein kinase A (PKA) signaling pathway also stimulates Ser269 and Ser275 phosphorylation of GCM1, which recruits CBP to mediate GCM1 acetylation and stabilization. Consequently, hCG stimulates the expression of GCM1 target genes, including the fusogenic protein syncytin-1, to promote placental cell fusion. Our study reveals a positive feedback loop between GCM1 and hCG regulating placental hCGβ expression and cell differentiation. PMID:26503785

  2. Ovulation and conception rates according intravaginal progesterone device and hCG or GnRH to induce ovulation in buffalo during the off breeding season

    Directory of Open Access Journals (Sweden)

    P.S. Baruselli

    2010-02-01

    Full Text Available The objective of this study was to evaluate the effect of intravaginal progesterone device (P4; first or second use of different ovulatory inductors on ovulation and conception rates in buffaloes during the off breeding season. Two hundred and forty two buffaloes were allocated in four groups and received P4 device of first or second use plus estradiol benzoate on Day 0 (D0. The P4 device was removed and a dose of PGF2α and eCG was administered on D9. On D11, buffaloes received hCG or GnRH and 16hs after the animals were inseminated. The ultrasound examination was performed on D0 to verify the ovarian status, from D9 to D14 to establish the moment of ovulation and on D40 for pregnancy diagnosis. Data were analyzed by ANOVA and Chi-square test. There was no effect of interaction. The ovulation and conception rate were similar for P4 device of first and second use, for hCG and GnRH. Results indicate that the use of P4 device for two times and the use of GnRH instead of hCG provide satisfactory ovulation and conception rate in buffalo during the off breeding season and might reduce the cost of the protocol for artificial insemination.

  3. [Diagnosis of pregnancy before the menstrual period is delayed. Interest of the determination of plasma chorionic gonadotropin (HCG) in fertility disorders].

    Science.gov (United States)

    Chartier, M; Barrat, J; Michelon, B; Soldat, M C

    1975-01-01

    Estimating plasma HCG levels in the last days of the menstrual cycle have very early diagnosis of pregnancy. In 86 cycles occurring in 65 women being treated for sterility the levels were estimated between the 10th and the 15th day following the low point in the temperature curve for the purpose of trying to estimate the practical use of this method. In 30 cycles studied one case of fertilisation took place and was confirmed by the evolution of a pregnancy. From the 11th day onwards with the exception of one solitary case the concentrations of HCG ranged between 15 and 405 mUl-2 degrees-IS-hCC/ml. These levels, therefore are higher than the apparent concentrations found in a group of women used as controls who were not pregnant (0 to 4.5 mUl/ml.). In 56 other cycles apparently normal periods followed on the expected date. All the same, the apparent concentration of HCG (2 to 32 mUl/ml) is far higher often than in the control group. The interference of LH in the level makes it impossible to decide between two hypotheses: whether raised levels of LH are associated with irregular menstrual function or with fertilisation, followed by premature expulsion of the oocyte.

  4. Triaging pregnancies of unknown location: the performance of protocols based on single serum progesterone or repeated serum hCG levels.

    Science.gov (United States)

    Guha, S; Ayim, F; Ludlow, J; Sayasneh, A; Condous, G; Kirk, E; Stalder, C; Timmerman, D; Bourne, T; Van Calster, B

    2014-05-01

    How does a protocol based on a single serum progesterone measurement perform as a triage tool in women with pregnancy of unknown location (PUL) in comparison to protocols based on serial hCG measurement? Triage based on the logistic regression model M4 (using initial hCG and hCG ratio (48 h/0 h)) classifies the majority of PUL into low and high risk groups, in contrast to a progesterone protocol based on a serum level threshold of 10 nmol/l. Low progesterone has been shown to identify failing pregnancies and those at low risk of complications. A prediction model (M4) based on the initial hCG and the hCG ratio at 0 and 48 h can successfully classify PUL into low and high risk groups. A multi-centre diagnostic accuracy study of 1271 women was performed retrospectively on data from women at St. George's Hospital (SGH, London, UK) between February 2005 and 2006, Queen Charlottes & Chelsea Hospital (QCCH, London, UK) between April 2009 and August 2012, and the Royal Prince Alfred Hospital (RPAH, Sydney, Australia) between February 2008 and October 2011. The end-points were the final observed outcome for each pregnancy as a failed PUL (low risk), intrauterine pregnancy (IUP, low risk), or ectopic pregnancy (EP, high risk), and any interventions or complications for EP during the follow-up period. Complete data were available for initial progesterone, 0/48 h hCG and final outcome in 431 of 534 women (81%) at SGH, 396/585 (68%) at QCCH and 96/152 (63%) at RPAH. Missing values were handled using multiple imputation. Three diagnostic approaches were used to classify PUL as high risk: a range of serum progesterone levels were evaluated (>10, 16 and 20 nmol/l) for the progesterone protocol, risk of EP given by the M4 model ≥5% for the M4-based protocol, and hCG ratio was between 0.87 and 1.66 for hCG cut-offs as previously published. Results were analysed using random intercept models or stratified analysis to account for variability between centres. The progesterone

  5. Human chorionic gonadotropin (hCG) regulates the expression of Steroidogenic acute regulatory protein (STAR)via the ERK1/2 pathway

    Institute of Scientific and Technical Information of China (English)

    WANG Xianzhong; SUN Yan; WU Jianyun; PAN Hongmei; ZHANG Jiahua

    2007-01-01

    It has previously been shown that Human Chorionic Gonadotropin (hCG) can stimulate steroidogenesis in Leydig cells.In the present study,the mechanisms of hCGstimulated steroidogenesis in Leydig cells of immaturated pigs were investigated.It was found that both hCG and 8Br-cAMP could enhance the expression level of both the Steroidogenic acute regulatory protein (STAR) and mRNA,and increase the activity of extracellular signal-regulated kinasel/2 (ERK1/2) significantly depending on stimulating time.However,the effect of 8-Br-cAMP was more significant than that of hCG.While appending the inhibitor of Protein Kinase A (PKA) to Leydig cells in culture,the expression level of StAR protein,mRNA and the activity of ERK1/2 began to drop significantly,but the level of StAR mRNA could still be detectable.While appending the inhibitor of MAPK (PD98059),the expression level of StAR protein and mRNA declined significantly.These results infer that at the beginning of hCG stimulation,hCG increases the level of StAR protein by cAMP-PKA.With prolonged stimulating time,hCG increases the level of StAR protein through cAMP-PKA-ERK1/2.

  6. HCG对不育症精子超微结构的影响%DThe effect of HCG to sperm's ultrastructure in male infertility

    Institute of Scientific and Technical Information of China (English)

    俞建军; 王培乐; 吴章穆; 陈昭典

    2001-01-01

    Objective To study the mechanisam of using HCG to treat male infertility. Methods 30 male infertility cases were selected randomly and their spermatozoa were fetched by masturbation. In every case, five sperms were observed under SEM (scan electronic microscope). After HCG had been given for 12 weeks, sperms were observed again. Results Sperms' ringed rips, acrosome membranes, plasmalemma, plasminic droplet changed significantly. Conclusion HCG had positive effect to sperms of male infertility patients.%目的探索 HCG治疗男性不育症的机理。方法随机选择男性不育症 30例,手淫法取精液每例扫描电镜观察精子五个,共 150个, HCG治疗 12周后,再作电镜观察。结果治疗前后的精子环状沟、顶体膜、质膜、胞浆小滴均有明显变化。结论 HCG治疗不育症疗效肯定。

  7. GnRH agonist trigger versus hCG trigger in GnRH antagonist in IVF/ICSI cycles: A review article

    Science.gov (United States)

    Alyasin, Ashraf; Mehdinejadiani, Shayesteh; Ghasemi, Marzieh

    2016-01-01

    Routinely, a bolus of 5.000-10.000 IU human chorionic gonadotropin (hCG) is used for the final follicular maturation and ovulation as a standard method. HCG has the same effect of luteinizing hormone (LH) with long half-life. It has the long lutheotrophic effect which increases the risk of ovarian hyper stimulation syndrome (OHSS). Recently, gonadotropin-releasing hormone agonist (GnRH-a) trigger has been used for the induction of final follicular maturation and ovulation with the aim of reducing the OHSS risk. Several studies have shown that the releases of endogenous follicular stimulating hormone (FSH) and LH after administration of GnRH agonist in in vitro fertilization (IVF) cycles are able to precede the final follicular maturation leading to removal of fertile oocyte with normal development of the embryo and ultimately pregnancy. But based on the results of some studies, using GnRH-a trigger leads to defect luteal-phase resulting to reduce the implantation and clinical pregnancy rates and also increase abortion in fresh embryo transfer cycles compared to routine IVF cycle with hCG triggering . Also, in recent years, studies have continued to modify the luteal phase support, so that the fresh embryo transfer is possible too. In this review, we examined the benefits, problems, and also ways to reform GnRH agonist triggering complications. PMID:27738657

  8. Efeito protetor da lactoferrina humana no trato gastrintestinal Efecto protector de la lactoferrina humana en el sistema gastrointestinal Protective effect of human lactoferrin in the gastrointestinal tract

    Directory of Open Access Journals (Sweden)

    Valterlinda Alves de O. Queiroz

    2013-03-01

    Full Text Available OBJETIVO: Descrever os mecanismos de ação da lactoferrina humana na proteção de morbidades gastrintestinais. FONTES DE DADOS: Revisão não sistemática da literatura utilizando como estratégia de busca pesquisa bibliográfica em bases de dados, as quais incluíram SciELO, Lilacs e MedLine entre 1990 e 2011. Os descritores utilizados foram: lactoferrina, leite materno/humano, gastrintestinal e imunidade, nos idiomas português e inglês. SÍNTESE DOS DADOS: A lactoferrina é a segunda proteína predominante no leite humano, com concentrações mais elevadas no colostro (5,0 a 6,7mg/mL em relação ao leite maduro (0,2 a 2,6mg/mL. Em contraste, o leite de vaca contém teores inferiores, 0,83mg/mL no colostro e 0,09mg/mL no leite maduro. A lactoferrina desempenha diversas funções fisiológicas na proteção do trato gastrintestinal. A atividade antimicrobiana está relacionada à capacidade de sequestrar ferro dos fluidos biológicos e/ou de desestruturar a membrana de micro-organismos. A lactoferrina possui também a capacidade de estimular a proliferação celular. A ação anti-inflamatória desempenhada pela lactoferrina está associada à capacidade de penetrar no núcleo do leucócito e bloquear a transcrição do fator nuclear Kappa B. Diante da importância da lactoferrina na prevenção de doenças infecciosas em crianças aleitadas ao peito, a indústria vem, por meio da engenharia genética, desenvolvendo tecnologias para expressar esta proteína recombinante humana em plantas e animais, na tentativa de adequar a composição das fórmulas infantis àquela do leite humano. CONCLUSÕES: A lactoferrina humana é um peptídeo com potencial para prevenir morbidades, especialmente às gastrintestinais. Evidências científicas dos efeitos protetores da lactoferrina humana fortalecem ainda mais a recomendação para prática do aleitamento materno.OBJETIVO: Describir los mecanismos de acción de la lactoferrina humana en la protecci

  9. Entre libertad y determinismo. Genes, cerebro y ambiente en la conducta humana. [Reseña

    OpenAIRE

    García-Cuadrado, J.A. (José Ángel)

    2008-01-01

    Reseña de Luis M» GONZALO SANZ, Entre libertad y determinismo. Genes, cerebro y ambiente en la conducta humana. Cristiandad (Colección Ciencia y Fe), Madrid 2007, 231 pp., 10,5 X 17,5, ISBN 978- 84-7057-519-8.

  10. Ocorrência de fascioliasis humana no município de Volta Redonda, RJ, Brasil

    Directory of Open Access Journals (Sweden)

    E Pile

    2000-08-01

    Full Text Available Através do resultado de exames coprológicos realizados em pacientes atendidos em postos de saúde e hospitais do município de Volta Redonda, assinala-se a primeira ocorrência da fascioliasis humana no Estado do Rio de Janeiro, Brasil.

  11. Humana looks to ISO registration to address quality improvement and customer satisfaction.

    Science.gov (United States)

    2003-01-01

    Seeking new ways to improve standardization of clinical operations and customer focus, Louisville, KY-based Humana, Inc. announced in November that it has become the first healthcare company to be registered in the U.S. under ISO 9001:2000, a quality management standard published by the International Organization for Standardization (ISO).

  12. Hacia una Salud Pública Pluralista: El Caso de los Plaguicidas y la Salud Humana

    National Research Council Canada - National Science Library

    Idrovo, Álvaro Javier

    2005-01-01

    .... El caso de los plaguicidas y los efectos en la salud humana es usado como ejemplo para mostrar los aportes y limitaciones de diferentes modelos teóricos en salud pública (sanitarista, biomédico, epidemiológico...

  13. La comunicación humana : principios básicos

    OpenAIRE

    Viana Orta, María Isabel

    2012-01-01

    Principios básicos de la comunicación humana. Comunicación oral, no verbal y persuasiva. El material forma parte de cursos de formación en temas de resolución de conflictos, comunicación y mediación.

  14. La clonación humana y el problema de la identidad

    National Research Council Canada - National Science Library

    Calise, Santiago Gabriel

    2015-01-01

    ... technique.El siguiente trabajo se propone indagar los problemas que la clonación humana acarrearía para la identidad, debido a que este concepto se ha erigido en uno de los principales argumentos para intentar fundamentar...

  15. La comunicación humana : principios básicos

    OpenAIRE

    Viana Orta, María Isabel

    2012-01-01

    Principios básicos de la comunicación humana. Comunicación oral, no verbal y persuasiva. El material forma parte de cursos de formación en temas de resolución de conflictos, comunicación y mediación.

  16. Heightened seizure susceptibility associated with brain dermoid cyst and the administration of human chorionic gonadotropin (hCG).

    Science.gov (United States)

    Milani, Paolo; Rocchi, Raffaele; Cerase, Alfonso; Rossi, Alessandro; Mazzocchio, Riccardo

    2007-07-15

    It is known that the intramuscular injection of human chorionic gonadotropin (hCG) lowers the threshold for motor evoked responses (MEPs) in the first dorsal interosseous (FDI) muscle to transcranial magnetic stimulation (TMS) in humans. We describe the case of a patient with a clinically silent left-sided nasofrontal dermoid cyst who, while being treated with hCG/LH for hypogonadotropic hypogonadism, presented with simple partial seizures, ipsilateral to the cyst, with secondary generalization. Motor cortex excitability was studied by single and paired TMS and MEPs were recorded from FDI. Resting motor threshold (RMT), active motor threshold (AMT), MEP size, intracortical inhibition (ICI) and intracortical facilitation (ICF) were tested during and after suspension of hormonal therapy. RMT and AMT were lower, MEP size was larger, ICI was decreased while ICF was slightly diminished during treatment. Overall, this indicated a reduced intracortical inhibition during hormonal therapy. It is concluded that treatment with hCG/LH may favour seizure onset in the presence of potentially epileptogenic lesions such as an intracranial dermoid cyst.

  17. Gerente de projetos: habilidades humanas e comportamentais / Project manager: human and behaviours skills

    Directory of Open Access Journals (Sweden)

    Edson Coutinho da Silva

    2016-04-01

    Full Text Available Um gerente de projetos deve priorizar as habilidades humanas e comportamentais do que as habilidades técnicas para a obtenção de êxito de projetos; uma vez que são as pessoas e a equipe que compõem um projeto. O artigo tem o propósito de descrever as habilidades humanas requeridas para um gestor conduzir a implementação de um projeto em uma organização, na busca de mitigar os conflitos com os stakeholders. Foi elaborada uma pesquisa descritiva alicerçadas por técnicas como a pesquisa-ação e estudo de caso. Os dados foram obtidos por meio da experiência de um dos pesquisadores deste artigo no projeto e por meio de seis entrevistas com membros da equipe. Os pesquisadores estabeleceram cinco habilidades humanas e comportamentais que são requeridas aos gerentes: liderança, comunicação, gestão de mudança, motivação e gestão de conflito; e as usou para fins de análise e discussão dos resultados. Concluiu-se, pelo projeto de implementação do ERP pesquisado neste estudo, que esta organização considerou prioritariamente as habilidades técnicas do que as humanas ao selecionar alguns de seus gestores; e foi exatamente a ausência de repertório de habilidades humanas que comprometeu o gerenciamento do projeto.

  18. Efeito protetor da lactoferrina humana no trato gastrintestinal Efecto protector de la lactoferrina humana en el sistema gastrointestinal Protective effect of human lactoferrin in the gastrointestinal tract

    OpenAIRE

    Valterlinda Alves de O. Queiroz; Ana Marlúcia O. Assis; Hugo da Costa R. Júnior

    2013-01-01

    OBJETIVO: Descrever os mecanismos de ação da lactoferrina humana na proteção de morbidades gastrintestinais. FONTES DE DADOS: Revisão não sistemática da literatura utilizando como estratégia de busca pesquisa bibliográfica em bases de dados, as quais incluíram SciELO, Lilacs e MedLine entre 1990 e 2011. Os descritores utilizados foram: lactoferrina, leite materno/humano, gastrintestinal e imunidade, nos idiomas português e inglês. SÍNTESE DOS DADOS: A lactoferrina é a segunda proteína predomi...

  19. Seguridad humana para las mujeres en las ciudades: reflexiones para politicas publicas urbanas con enfoque de genero

    National Research Council Canada - National Science Library

    Montoya Ruiz, Ana Milena

    2013-01-01

    ... por el enfoque de seguridad humana, en las cuales se establecen los minimos que requieren las mujeres para gozar de una vida urbana renovada y superar las limitaciones existentes en la ciudad como espacio...

  20. Valor agregado por las áreas de gestión humana a las organizaciones colombianas

    OpenAIRE

    Calderón Hernández, Gregorio

    2007-01-01

    A partir de dos cuestionamientos ¿cuál es el papel de las áreas de gestión humana? y ¿cómo hacer para que la acción de gestión humana sea significativa para las empresas? formulados en el seno del comité académico de la Asociación Colombiana de Gestión Humana, ACRIP, surge la presente investigación cuyo interrogante central fue ¿Agregan valor las áreas de gestión humana a las organizaciones colombianas? y ¿cómo lo hacen? Los resultados de la investigación se estructuran en ocho capítulos,...

  1. Seguridad humana en Colombia: donde no hay bienestar no puede haber paz

    Directory of Open Access Journals (Sweden)

    María Teresa Aya Smitmans

    2006-01-01

    Full Text Available Este artículo trata sobre los retos que amenazan a la soberanía clásica en el sistema internacional y, en especial, a la seguridad humana. Ésta, entendida como una concepción ampliada de la seguridad tradicional, refuerza la idea del individuo como centro de las relaciones internacionales y pone su seguridad por encima de la seguridad estatal. Asimismo, el surgimiento de nuevos actores hacen que la gobernabilidad estatal se vea debilitada a menos que se piense en aumentar la responsabilidad estatal para con sus ciudadanos. Es así como la seguridad humana constituye un concepto importante en el siglo XXI para una gobernabilidad responsable. El artículo examina el caso colombiano

  2. Seguridad humana en Colombia: donde no hay bienestar no puede haber paz

    Directory of Open Access Journals (Sweden)

    María Teresa Aya Smitmans

    2006-11-01

    Full Text Available Este artículo trata sobre los retos que amenazan a la soberanía clásica en el sistema internacional y, en especial, a la seguridad humana. Ésta, entendida como una concepción ampliada de la seguridad tradicional, refuerza la idea del individuo como centro de las relaciones internacionales y pone su seguridad por encima de la seguridad estatal. Asimismo, el surgimiento de nuevos actores hacen que la gobernabilidad estatal se vea debilitada a menos que se piense en aumentar la responsabilidad estatal para con sus ciudadanos. Es así como la seguridad humana constituye un concepto importante en el siglo XXI para una gobernabilidad responsable. El artículo examina el caso colombiano.

  3. El problema del discurso acerca de la individualidad genética humana

    OpenAIRE

    Ordóñez Vásquez, Adriana

    2008-01-01

    Se abordó el problema filosófico acerca de la individualidad genética humana, desde un discurso ontológico. Determinándose un problema lógico, epistemológico, semiológico y ontológico, al mismo tiempo que genético. Se presenta el paralelismo entre rasgos de la individualidad señalados por la tradición filosófica clásica y su posible reformulación del discurso desde la genética humana actual. Prueba la pertinencia semiótica de Peirce - biosemiótica en el desarrollo del problema y propone un mo...

  4. Manipulação genética e dignidade humana

    OpenAIRE

    Oliveira, Simone Born de

    2001-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas Um tema como a manipulação genética e dignidade humana: da bioética ao direito, tem por fim verificar o desenvolvimento da pesquisa científica na área da genética, com suas manipulações e respectivas conseqüências sobre a dignidade humana, a bioética e o direito. Tem que ser possível definir a influência da ética e do direito no desenvolvimento das pesquisas científicas. Para definir essas possibi...

  5. ¿Qué pasa en el cerebro de los perros cuando ven caras humanas?

    Directory of Open Access Journals (Sweden)

    Laura V. Cuaya

    2016-05-01

    Full Text Available Cuando tu perro te ve, no sólo se iluminan sus ojos, también su cerebro. Aquí resumimos un experimento que realizamos para conocer el procesamiento cerebral de las caras humanas en perros, utilizando imágenes de resonancia magnética funcional, en el que encontramos actividad en la corteza temporal, frontal y el núcleo caudado. La actividad en la corteza temporal sugiere que los perros procesan las caras de manera similar a nosotros. Fue inesperado encontrar actividad en el núcleo caudado, porque sugiere que los perros procesan las caras humanas como recompensas, incluso si son caras de humanos desconocidos.

  6. A psicoterapia diante da liberdade humana: uma discussão orteguiana

    Directory of Open Access Journals (Sweden)

    Eloisa Nogueira Aguiar

    2012-04-01

    Full Text Available O artigo aborda a liberdade humana a partir do legado filósofo de José Ortega y Gasset como possibilidade de caminho para a compreensão humana. Afinal, a psicoterapia lida essencialmente com o problema da liberdade, já que o homem responde ao que lhe vem ao encontro. O filósofo madrileno, ao colocar o homem como protagonista de sua vida, favorece a abertura a um modo específico de atenção, demarcando uma atitude clínica que renuncie qualquer redução do humano a dimensões meramente orgânicas, psicológicas ou sociais, reduzindo-o, portanto, à figura amorfa de quem, nada ou pouco, pode fazer por si mesmo.

  7. Interdisciplinaridade e complexidade: uma construção em ciências humanas

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Severo Garcia Jr.

    2015-12-01

    Full Text Available http://dx.doi.org/10.5007/1807-1384.2015v12n2p1 O presente ensaio é um percurso de reflexão em torno de conceitos relacionados à construção e produção de conhecimentos interdisciplinar em ciências humanas. Parte-se de ponderações sobre os conceitos de disciplinaridade, multidisciplinaridade, interdisciplinaridade, transdisciplinaridade e desdobra-se na discussão do pensamento complexo proposto por Edgar Morin. Compreende-se que a partir da aventura interdisciplinar é possível ponderações acerca das relações e transformações da condição humana frente aos novos alicerces de saberes na modernidade e suas consequências sociais, econômicas e subjetivas.

  8. Estimating the net effect of progesterone elevation on the day of hCG on live birth rates after IVF: a cohort analysis of 3296 IVF cycles.

    Science.gov (United States)

    Venetis, Christos A; Kolibianakis, Efstratios M; Bosdou, Julia K; Lainas, George T; Sfontouris, Ioannis A; Tarlatzis, Basil C; Lainas, Tryfon G

    2015-03-01

    What is the proper way of assessing the effect of progesterone elevation (PE) on the day of hCG on live birth in women undergoing fresh embryo transfer after in vitro fertilization (IVF) using GnRH analogues and gonadotrophins? This study indicates that a multivariable approach, where the effect of the most important confounders is controlled for, can lead to markedly different results regarding the association between PE on the day of hCG and live birth rates after IVF when compared with the bivariate analysis that has been typically used in the relevant literature up to date. PE on the day of hCG is associated with decreased pregnancy rates in fresh IVF cycles. Evidence for this comes from observational studies that mostly failed to control for potential confounders. This is a retrospective analysis of a cohort of fresh IVF/intracytoplasmic sperm injection cycles (n = 3296) performed in a single IVF centre during the period 2001-2013. Patients in whom ovarian stimulation was performed with gonadotrophins and GnRH analogues. Natural cycles and cycles where stimulation involved the administration of clomiphene were excluded. In order to reflect routine clinical practice, no other exclusion criteria were imposed on this dataset. The primary outcome measure for this study was live birth defined as the delivery of a live infant after 24 weeks of gestation. We compared the association between PE on the day of hCG (defined as P > 1.5 ng/ml) and live birth rates calculated by simple bivariate analyses with that derived from multivariable logistic regression. The multivariable analysis controlled for female age, number of oocytes retrieved, number of embryos transferred, developmental stage of embryos at transfer (cleavage versus blastocyst), whether at least one good-quality embryo was transferred, the woman's body mass index, the total dose of FSH administered during ovarian stimulation and the type of GnRH analogues used (agonists versus antagonists) during ovarian

  9. Results of a pilot study in the U.S. and Vietnam to assess the utility and acceptability of a multi-level pregnancy test (MLPT) for home monitoring of hCG trends after assisted reproduction.

    Science.gov (United States)

    Shochet, Tara; Comstock, Ioanna A; Ngoc, Nguyen Thi Nhu; Westphal, Lynn M; Sheldon, Wendy R; Loc, Ly Thai; Blum, Jennifer; Winikoff, Beverly; Blumenthal, Paul D

    2017-08-22

    To evaluate the utility and acceptability of using multi-level pregnancy tests (MLPTs) at home to monitor hCG trends following assisted reproductive technology (ART). One hundred and four women presenting for ART at either Stanford Medicine Fertility and Reproductive Health Clinic (Stanford, CA) or Hung Vuong Hospital (Ho Chi Minh City, Vietnam) participated in this pilot study. Women were asked to perform the MLPT at home, primarily on days when they were also scheduled to receive standard clinic-based serum hCG testing. These tests were administered up to 6 times over the 6-week period following embryo transfer or intrauterine insemination (IUI). Concordance of serial hCG readings for each time point was assessed by comparing trends in urine MLPT results with trends in serum hCG. Stable or increasing hCG level was interpreted as an indication of a progressing pregnancy, while a declining hCG was interpreted as a lack of established or progressing pregnancy. At study end, all participants were asked about the acceptability and convenience of using the MLPT at home for monitoring hCG trends following ART. Data from both urine and serum testing are available for 156 of 179 clinic visits (87.2%). There was high concordance of serial trend results between the two types of tests: among the 156 sets of serum and urine hCG data points, 150 (96.2%) showed a matching trend in hCG pattern and 6 (3.8%) resulted in a discordant trend. Seventy-three percent of women reported being satisfied or very satisfied with using the MLPTs at home. Almost all (96.6%) said that the MLPT was easy or very easy to use. The MLPT offers women and health care providers a client-friendly diagnostic tool to detect very early pregnancy and monitor its progress. This study was registered on clinicaltrials.gov as NCT01846403 (May 1, 2013), and NCT01919502 (August 5, 2013).

  10. Dirofilariose pulmonar humana, adquirida no Brasil: comunicação de um caso

    OpenAIRE

    Amato Neto,Vicente; Amato,Valdir Sabbaga; Moraes Júnior,Antonio Carlos Pedroso de; Cerri, Giovanni Guido

    1993-01-01

    É comunicado caso de dirofilariose humana, adquirida no Brasil. Trata-se do segundo acometimento dessa natureza publicado em literatura científica. Como expressão clínica, foram evidenciados dois nódulos pulmonares, através de exame radiológico convencional e de tomografia computadorizada. O diagnóstico decorreu de análise histopatológica de uma das lesões.

  11. FORMAÇÃO HUMANA: CURRÍCULO PARA O DESENVOLVIMENTO HUMANO

    Directory of Open Access Journals (Sweden)

    Adreana Dulcina Platt

    2009-09-01

    Full Text Available No presente artigo pretendemos debater a análise crítico-reflexiva das premissas que sustentam a práxis da formação humana perpassando transversalmente os conceitos de desenvolvimento humano e o currículo. Entendemos o currículo de formação humana a partir da filosofia da práxis. Coadunando com nossas perspectivas epistemológicas, concordamos com a leitura de Semeraro (2001b, quando aponta que Gramsci melhor desvela o processo de elaboração da filosofia da práxis a partir de novas relações sociais; ou seja, desligado das puras abstrações, o filósofo italiano observa na “unidade das tensões dualistas e as contradições ricas e complexas” (“entre teoria/prática, intelectuais/massa, organização/espontaneidade, sociedade política/sociedade civil, ocidente/oriente, norte/sul, história do mundo/história particular”, a articulação para o desenvolvimento da atividade humana plena. A partir destes pressupostos colocados aqui enquanto premissas para a sistematização de nossos estudos, nos debruçaremos sobre dois grandes objetivos: (1 compreender o processo de humanização a partir da esfera das objetivações sociais e (2 a constituição do currículo de formação humana atrelado aos diferentes modos de produção, uma vez que demanda em diferentes formações sociais.

  12. Hans Sperber e Freud: a origem sexual da linguagem humana e a psicanálise

    Directory of Open Access Journals (Sweden)

    Maria Antonieta Amarante de Mendonça Coh

    2014-03-01

    Full Text Available Neste trabalho, discute-se a relação entre a psicanálise, a linguageme sua origem sexual, tendo por base dois autores: Hans Sperber(1912, cuja proposta é a de que a linguagem humana falada temuma origem e um desenvolvimento vinculados ao sexual; SigmundFreud, nos textos em que trata de questões relativas à linguagemem sentido estrito.

  13. Posibles Efectos en la Salud Humana por Ingestión Excesiva de Fluoruros

    OpenAIRE

    Rodolfo Trejo Vázquez

    2005-01-01

    Se presenta un compendio de información relacionada con los beneficios asociados a la ingesta de dosis correctas de fluoruros, sobre los procedimientos para medir la concentración de éstos en el agua y sobre los efectos que puede causar a la salud humana la ingestión de cantidades inmoderadamente altas de fluoruros; y también sobre algunas maneras de atenuación de estos efectos indeseables

  14. Relevancia e Inferencia: Procesos cognitivos propios de la comunicación humana

    Directory of Open Access Journals (Sweden)

    Moya Pardo Constanza

    2006-06-01

    Full Text Available Este artículo pretende mostrar los planteamientos cognitivos más representativos de la Teoría de la Relevancia propuesta por Spelber & Wilson con respecto al modelo ostensivoinferencial. Este modelo plantea un mecanismo deductivo explícito que da cuenta de los procesos y estrategias que permiten el paso del significado literal a la interpretación pragmática de los mensajes en el proceso de comunicación humana.

  15. A formação humana na perspectiva histórico-ontológica

    Directory of Open Access Journals (Sweden)

    Dermeval Saviani

    2010-01-01

    Full Text Available El tema de la formación humana está en el centro de la filosofía de la educación cuyo objetivo es precisamente el proceso de promoción humana, llevado a cabo por la educación. Partiendo de la vigilancia crítica, propia de la filosofía, el texto esboza una fenomenología de la época actual comprobando que las ideas actualmente hegemónicas en la educación, son centradas en la crítica a la razón y a las nociones de la verdad y de la objetividad. A ese neo pragmatismo que con la intención de oponerse a la metafísica acaba siendo profundamente metafísico reduciendo todo al lenguaje, los autores contraponen el pensamiento de Marx como una filosofía de historicismo en que la causa no son los sujetos abstractos, sino los individuos reales, sujetos históricos que se constituyen como síntesis de relaciones sociales. Para esto se recurre a la reflexión histórica ontológica sobre la formación humana incluida en los "Manuscritos Económico Filosóficos de 1844" de Marx. El artículo concluye con la defensa de la tesis de que el acceso a los clásicos es condición necesaria para la formación humana.

  16. Manifestaciones psiquiátricas desencadenadas por el virus de la inmunodeficiencia humana

    OpenAIRE

    Roberto Anselmo Ramos Valverde

    2014-01-01

    La alta morbilidad de perturbaciones mentales y del comportamiento, desencadenada por el virus de la inmunodeficiencia humana (VIH), asombra a colaboradores cubanos en la ciudad de Maputo, capital de Mozambique. Solo apelando a los conocimientos actuales de la Psicoendocrinoneuroinmunologia, que describe la vinculación basada en la teoría de la complejidad de este suprasistema, que comparte receptores y mediadores químicos, se puede disipar el asombro y llegar a comprender la esencia científi...

  17. Cuentos: concurso cuento infantil Facultad de Ciencias Humanas 40 años

    OpenAIRE

    Ramírez, Andrea Natalia; Díaz, Óscar Orlando; Vélez Castaño, Hernán Darío

    2007-01-01

    Este volumen incluye los tres cuentos ganadores del concurso de cuento infantil celebrado con ocasión de la celebración de los 40 años de la Facultad de Ciencias Humanas. / Contenido. Preliminares; Capítulo 1 - Señor destino, hada vida; Capítulo 2 - Amor de príncipe; Capítulo 3 - Monos y sábados; Anexos.

  18. La energía humana el esfuerzo físico

    Directory of Open Access Journals (Sweden)

    Luis Suárez Flórez

    2011-02-01

    Full Text Available Se llama la atención sobre la energía humana, su importancia como elemento de productividad y como principio ó quizás como fin de la actividad deportiva. Se estudia el máximo esfuerzo físico, así como también algunos conceptos acerca de la energía aeróbica y la energía anaeróbica.

  19. Posibles Efectos en la Salud Humana por Ingestión Excesiva de Fluoruros

    OpenAIRE

    Rodolfo Trejo Vázquez

    2005-01-01

    Se presenta un compendio de información relacionada con los beneficios asociados a la ingesta de dosis correctas de fluoruros, sobre los procedimientos para medir la concentración de éstos en el agua y sobre los efectos que puede causar a la salud humana la ingestión de cantidades inmoderadamente altas de fluoruros; y también sobre algunas maneras de atenuación de estos efectos indeseables

  20. Validation of 125I-hCG as a marker for elimination of hCG and stability of 125I-hCG after in vivo injection in humans

    DEFF Research Database (Denmark)

    Christensen, T B; Marqversen, J; Engbaek, F;

    1999-01-01

    We have recently introduced 125I-hCG as an elimination marker in patients with human chorionic gonadotrophin (hCG) producing testicular cancer. 125I-hCG is a well-known reagent in clinical biochemistry and is used extensively in hCG assays. Previous studies have shown that the iodination process...... leaves the hCG molecule mainly intact. The iodination, purification and stability of 125I-hCG tracer are described. The aim of the present study was to determine whether or not 125I is associated with hCG after the injection of 125I-hCG intravenously (i.v.) in humans. Three different methods were used....... Following injection of 125I-hCG, the plasma disappearance of radioactivity and hCG were followed for a period of 28 days in 13 normal subjects. Serum from a normal healthy male following injection of 125I-hCG was analysed using a double antibody direct binding radioimmunoassay specific for holo-hCG and high...

  1. Impact of Buserelin Acetate or hCG Administration on the Day of First Artificial Insemination on Subsequent Luteal Profile and Conception Rate in Murrah Buffalo (Bubalus bubalis).

    Science.gov (United States)

    Pandey, A K; Ghuman, Sps; Dhaliwal, G S; Agarwal, S K; Phogat, J B

    2016-08-01

    This study was designed to investigate the impact of buserelin acetate (BA) or human chorionic gonadotropin (hCG) administration on the day of first artificial insemination (AI) on subsequent luteal profile (diameter of corpus luteum (CL) and plasma progesterone) and conception rate in Murrah buffalo. The present experiment was carried out at two locations in 117 buffalo that were oestrus-synchronized using cloprostenol (500 μg) administered (i.m.) 11 days apart followed by AI during standing oestrus. Based on treatment (i.m.) at the time of AI, buffalo were randomly categorized (n = 39 in each group) into control (isotonic saline solution, 5 ml), dAI-BA (buserelin acetate, 20 μg) and dAI-hCG (hCG, 3000 IU) group. Out of these, 14 buffalo of each group were subjected to ovarian ultrasonography on the day of oestrus to monitor the preovulatory follicle and on days 5, 12, 16 and 21 post-ovulation to monitor CL diameter. On the day of each sonography, jugular vein blood samples were collected for the estimation of progesterone concentrations. All the buffalo (n = 117) were confirmed for pregnancy on day 40 post-ovulation. The conception rate was better (p hCG (66.7%) groups as compared to their control counterparts (30.8%). Furthermore, the buffalo of dAI-hCG group had improved (p  0.05) to exhibit stimulatory impact of treatment on luteal profile when compared to control group. In brief, buserelin acetate or hCG treatment on the day of first AI leads to an increase in conception rate; however, an appreciable impact on post-ovulation luteal profile was observed only in hCG-treated Murrah buffalo. © 2016 Blackwell Verlag GmbH.

  2. The luteotrophic effect of homoplastic pituitary pars distalis homogenate, PMSG, and HCG on the corpora lutea of the hypophysectomized frog, Rana cyanophlyctis (SCHN).

    Science.gov (United States)

    Pancharatna, M; Saidapur, S K

    1984-03-01

    The effect of homoplastic pituitary pars distalis homogenate (PDH), PMSG, and HCG on the postovulatory follicles/corpora lutea (CL) of the frog Rana cyanophlyctis was studied to elucidate the factors regulating the life span of the luteal cells. Ovulation and spawning was induced in hypophysectomized frogs using PDH. Starting from Day 1 of spawning 1/2 PDH, 50 IU PMSG, or 50 IU HCG was injected daily for 3 days. In the saline-injected control frogs, the granulosa lutein cells regressed markedly on Day 2 with a steady progressive increase in the pycnosis of their nuclei. The sudanophilic lipid droplets of the luteal cells were fine on Day 1 but became coarser and reduced in number on subsequent days. Histochemically, the luteal cell 3 beta-HSDH and G-6-PDH also decreased drastically by Day 2. In PDH-treated frogs the granulosa lutein cells were healthy on all 4 days of the experiment. The nuclear diameter of the luteal cells increased progressively due to PDH. The pycnosis of the luteal cells was limited to 7.6% on Day 4 due to PDH as opposed to 68% seen in the controls. Histochemically, 3 beta-HSDH and G-6-PDH activities remained much higher than in the controls with abundant sudanophilic lipids (both fine and coarse) in the luteal cells of PDH treated frogs even on Day 4. PMSG treatment also maintained the granulosa lutein cells beyond their normal life span but the luteotrophic effect was less than that of PDH. HCG was least effective. The present studies suggest that the structural integrity of CL in the frog can be extended beyond the normal life span by injecting PDH or PMSG.

  3. Aspectos médico legales de la clonación humana

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    Marco Mairena Navarro

    2002-09-01

    Full Text Available Las técnicas de reproducción asistida, y entre ellas la clonación humana, suscitan interrogantes éticas. Su empleo promete beneficios para la humanidad y, específicamente para parejas infértiles la satisfacción de ser madres y padres. En este artículo se debaten las regulaciones y las implicaciones jurídicas de dicha actividad, actualizándonos en el acontecer mundial y nacional del tema. Se argumenta que la clonación humana ya es una realidad y como si esta técnica se regula promueve la vida y la dignidad humanas. Además se propone que esta técnica se entiende mejor no en términos moralistas, sino contextuales que responden a situaciones reales de la vida, específicamente una ética de la responsabilidad.The techniques of assisted reproduction, among them human cloning, rises ethical questions. Their use promises benefits for humanity and, specifically for infertile couples, the satisfaction of being parents. This article discusses the regulations and juridical implications of this activity, trying to take us into the actual international and national reality. lt is argued that human cloning promotes human life and dignity. In addition, it is proposed that this technique is best understood not in moralistic terms, but rather in terms of contexts that respond to real life situations, specifically an ethics of responsibility.

  4. PROPUESTA DE UN MODELO DE GESTION HUMANA Y CULTURA ORGANIZACIONAL PARA PyMES INNOVADORAS

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    RAFAEL IGNACIO PEREZ URIBE

    2003-07-01

    Full Text Available La gestión humana y cultura organizacional son conceptos inseparables en cualquier tipo de organización y han sido tratados extensamente en el ámbito académico general, pero no en el caso de las PyMES. Las condiciones sociales, económicas y culturales de este nuevo siglo hacen imprescindible que las empresas medianas y pequeñas sean altamente creativas, innovadoras, se adapten ágilmente a los cambios, sobrevivan y crezcan, y para lograrlo necesariamente deben contar con una fuerza laboral comprometida, capacitada y motivada, que trabaje en busca del logro de la misión de la organización, pero que a la vez sienta que están logrando satisfacer sus deseos, expectativas y necesidades más profundas. En este artículo se revisan algunos planteamientos que profundizan sobre gestión humana y cultura organizacional de manera integral y que sirven de guía básica temática para el diseño de un modelo de gestión humana.

  5. Competencias distintivas en las pymes: un aporte desde gestión humana

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    Gregorio Calderón Hernández

    2006-06-01

    Full Text Available Con el fin de establecer de qué manera se está apoyando la competitividad por parte de la gestión humana en las pymes, se adelantó una investigación en 16 pequeñas y medianas unidades productivas de Manizales, en donde se estudiaron las competencias distintivas que más inciden sobre los factores de competitividad empresarial. Desde el punto de vista teórico se tomaron el enfoque sistémico de la competitividad, la teoría de recursos y capacidades, y la perspectiva estratégica de la gestión humana. Se contrastaron las competencias distintivas en las pymes seleccionadas y se analizaron los hallazgos a partir del modelo teórico construido. El abordaje empírico se hizo desde un enfoque cualitativo, realizando entrevistas a los gerentes o responsables de gestión humana de estas unidades productivas.

  6. Effect of ghrelin on proliferation, apoptosis and secretion of progesterone and hCG in the placental JEG-3 cell line.

    Science.gov (United States)

    Rak-Mardyła, Agnieszka; Gregoraszczuk, Ewa

    2010-07-01

    To determine the effect of ghrelin on placental cell proliferation, apoptosis and hormone secretion we cultured human JEG-3 cells with 100, 250, 500 or 1000 pg/ml of ghrelin for 48 hours. Ghrelin stimulated cell proliferation and decreased caspase-3 activity. All of the investigated ghrelin concentrations decreased progesterone (P(3)) but had no effect on human chorionic gonadotrophin (hCG) secretion. Stimulatory effects on cell proliferation paralleled inhibitory effects on cell apoptosis suggesting a possible role for ghrelin in placental formation or remodeling.

  7. Análisis multisistémico de la comunicación humana

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    José Torregrosa-Azor

    2013-03-01

    Full Text Available En aquest article es presenta el mètode multisistèmic per a l’anàlisi de la comunicació humana. En primer lloc, es fa una revisió del concepte comunicació humana multisistèmica que s’entén com l’intercanvi de missatges complexos que es transmeten mitjançant una modalitat combinatòria de canals físics i somàtics. Aquests missatges són codificats i descodificats per sistemes semiòtics semblants, però alhora distints, que es coestructuren internament i s’interrelacionen els uns amb els altres amb l’únic objectiu de comunicar. Així doncs, la  comunicació humana multisistèmica no només és possible a través del sistema lingüístic que ens caracteritza y diferencia com a espècie, sinó que, a més a més, hi intervenen altres sistemes semiòtics que es coestructuren internament, s’interrelacionen els uns amb els altres i són coexpressius amb el llenguatge verbal. En segon lloc, es descriuen les investigacions més rellevants en aquest camp que examinen la correlació que es produeix entre els diferents sistemes semiòtics de la comunicació humana -principalment, llenguatge, parallenguatge i kinèsica-. Per tant, l’anàlisi de la comunicació humana multisistèmica estudia no només la diversitat de sistemes semiòtics que interactuen i s’interrelacionen, sinó també els mecanismes que regulen la relació que s’hi estableix. És per això que es considera el concepte de ‘sistema’ fonamentat en la Teoria General de Sistemes, i es justifica la selecció del mot ‘multisistèmic’ com l’alternativa més clara i inequívoca. Finalment, s’exposa el procés d’anàlisi multisistèmic, la descripció de les fases analítiques i els mètodes emprats, així com també la selecció dels instruments d’anàlisi que s’hi fan servir.

  8. Development of a hot intergalactic medium in spiral-rich galaxy groups: the example of HCG 16

    Science.gov (United States)

    Vrtilek, Jan M.; O'Sullivan, Ewan; David, Laurence P.; Giacintucci, Simona; Zezas, Andreas; Mamon, Gary; Ponman, Trevor J; Raychaudhury, Somak

    2014-08-01

    Galaxy groups provide the environment in which the majority of galaxies evolve, with low velocity dispersions and small galaxy separations that are conducive to tidal interactions and mergers between group members. X-ray observations reveal the frequent presence of hot gas in groups, with larger quantities linked to early-type galaxies, whereas cold gas is common in spiral-dominated groups. Clarification of the origin and role of the hot medium is central to the understanding of the evolution of the galaxy population and of all phases of the IGM.We here report on the nuclear activity, star formation and the high luminosity X-ray binary populations of the spiral-dominated, likely not yet virialized, group HCG 16, as well as on its intra-group medium, based principally on deep (150 ks) Chandra X-ray observations of the group, as well as new Giant Metrewave Radio Telescope (GMRT) 610 MHz radio data. We confirm the presence of obscured active nuclei in NGC 833 and NGC 835, and identify what may be a previously unrecognized nuclear source in NGC 838; all are variable. NGC 838 and NGC 839 are both starburst-dominated systems, with galactic superwinds that show X-ray and radio evidence of IGM interaction, but only weak nuclear activity; NGC 848 is also dominated by emission from its starburst.We confirm the existence of a faint, extended low-temperature (0.3 keV) intra-group medium, a subject of some uncertainty in earlier studies. The diffuse emission is strongest in a ridge linking the four principal galaxies, and is at least partly coincident with a large-scale HI tidal filament, indicating that the IGM in the inner part of the group is highly multi-phase. We conclude that starburst winds and shock-heating of stripped HI may play an important role in the early stages of IGM formation, with galactic winds contributing 20-40% of the observed hot gas in the system.

  9. Induction of ovulation in Xenopus without hCG injection: the effect of adding steroids into the aquatic environment

    Science.gov (United States)

    2011-01-01

    Background The African clawed frog, Xenopus laevis, is widely used in studies of oogenesis, meiotic cell cycle and early embryonic development. However, in order to perform such studies, eggs are normally collected after the injection of hCG into the dorsal lymph sac of fully-grown female frogs following pre-injection of PMSF. Although this protocol is established and used as standard laboratory approach, there are some concerns over whether the injections could cause the transmission of deleterious microorganisms. Moreover, these injection protocols require a competent skilled worker to carry out the procedure efficiently. Methods Recently, we established a novel method to induce fish ovulation by simply adding the natural maturation-inducing hormone of teleosts, 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one (17,20 beta-DHP), into the surrounding water. In the present study, we demonstrate how we can induce ovulation in frogs using the same methodology. Results In frogs, progesterone was effective in the induction of oocyte maturation in vitro. We then examined the ability of progesterone to induce ovulation in frogs. However treatment of frogs with progesterone alone only occasionally induced ovulation in vivo. The number of oocytes and the frequency of ovulation were significantly lower than that induced by hCG-injection. Thus, conditions were improved by using a combination of progesterone with estradiol and by pre-treating frogs with low concentrations of progesterone or estradiol. Finally, we established an efficient means of inducing ovulation in frogs which involved pre-treatment of frogs with salt solution followed by a mixture of estradiol and progesterone at high concentration. The frequency and numbers of oocytes obtained were identical to those resulting from PMSG-hCG induction. Fertilization rate of eggs ovulated by the new treatment method was comparable to eggs obtained by hCG-injection and juveniles developed normally. Conclusions To conclude, we

  10. DIGNIDAD HUMANA: RECONOCIMIENTO Y OPERACIONALIZACIÓN DEL CONCEPTO DIGNIDADE HUMANA: RECONHECIMENTO E OPERACIONALIZAÇÃO DO CONCEITO HUMAN DIGNITY: CONCEPT ACKNOWLEDGEMENT AND OPERATIONALIZATION

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    Monique Pyrrho

    2009-01-01

    Full Text Available La dignidad humana, presente en la Declaración de los Derechos Humanos e incluso en recientes declaraciones internacionales sobre bioética, recibió últimamente duras críticas como referente bioético. El uso impreciso del término "dignidad", sin una clara definición, al ser atribuido al individuo como valor innato y desvinculado de sus referencias culturales, culmina en su sustitución por un concepto más claro y operacional: el de "autonomía". El presente trabajo enfrenta la cuestión conceptual de la dignidad humana como construcción relacional que se obtiene mediante el reconocimiento del otro. De esta manera, este término, más amplio y móvil históricamente que el concepto principialista de autonomía, incorpora en su definición y operacionalización las diversidades individuales, sociales y culturales.O conceito de dignidade human a presente na Declaração dos Direitos Humanos e inclusive em recentes declarações internacionais de bioética, ganhou últimamente duras críticas como referencial bioético. O uso impreciso do termo "dignidade", sem uma clara definição, ao ser atribuido ao indivíduo como valor inato e desvinculado de seus referenciais culturais, culmina com sua substituição por um conceito mais claro e operacional de "autonomia". O presente trabalho enfrenta a questão conceitual da dignidade humana como construção relacional que se obtêm mediante o reconhecimento do outro. Desta maneira, este termo, mais amplo e históricamente móvel que o conceito principialista de autonomia, incorpora em sua definição e operacionalização as diversidades individuais, sociais e culturais.Human dignity, present in the Declaration of Human Rights and also in recent international declarations on bioethics, has currently received harsh criticism as a bioethical term. The imprecise use of the term "dignity", without a clear definition, attributed to the individual as innate value and disconnected from its cultural

  11. Effect of recombinant-LH and hCG in the absence of FSH on in vitro maturation (IVM) fertilization and early embryonic development of mouse germinal vesicle (GV)-stage oocytes.

    Science.gov (United States)

    Dinopoulou, Vasiliki; Drakakis, Peter; Kefala, Stella; Kiapekou, Erasmia; Bletsa, Ritsa; Anagnostou, Elli; Kallianidis, Konstantinos; Loutradis, Dimitrios

    2016-06-01

    During in vitro maturation (IVM), intrinsic and extrinsic factors must co-operate properly in order to ensure cytoplasmic and nuclear maturation. We examined the possible effect of LH/hCG in the process of oocyte maturation in mice with the addition of recombinant LH (r-LH) and hCG in our IVM cultures of mouse germinal vesicle (GV)-stage oocytes. Moreover, the effects of these hormones on fertilization, early embryonic development and the expression of LH/hCG receptor were examined. Nuclear maturation of GV-stage oocytes was evaluated after culture in the presence of r-LH or hCG. Fertilization rates and embryonic development were assessed after 24h. Total RNA was isolated from oocytes of different stages of maturation and from zygotes and embryos of different stages of development in order to examine the expression of LH/hCG receptor, using RT-PCR. The in vitro nuclear maturation rate of GV-stage oocytes that received hCG was significantly higher compared to the control group. Early embryonic development was increased in the hCG and LH cultures of GV oocytes when LH was further added. The LH/hCG receptor was expressed in all stages of in vitro matured mouse oocytes and in every stage of early embryonic development. Addition of hCG in IVM cultures of mouse GV oocytes increased maturation rates significantly. LH, however, was more beneficial to early embryonic development than hCG. This suggests a promising new technique in basic science research or in clinical reproductive medicine. Copyright © 2016 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  12. The Effect of Human Recombinant Interferon Gamma (hrIFN-γ) on hCG Secretion of Trophoblast and Protein Synthesis of Decidual Tissue in Vitro

    Institute of Scientific and Technical Information of China (English)

    曹咏清; 陈幼珍

    1996-01-01

    In this study the effect of human recombinant interferon gamma (hrIFN-γ) on hCG secretion of human first trimester trophoblast and protein synthesis of decidual tissue was investigated in vitro. The results indicated that hrIFN-γ at the doses of 250 U/ml medium and 2500 U/ml medium decreased hCG secretion of trophoblast obviously (P < 0. 0,5, P<0. 01 ) in a dose dependent manner. The effect of hrIFN-γ on protein synthesis at the doses of 10 U to 1,000 U/ml medium inhibited the3 H leucine incorporation obviously. The cpm values between control and experimental groups were significantly different (P <0. 05 ) in a dosedependent manner. Furthermore its inhibitory effect is in a dose-dependent manner and was neutralized by IFN-γ antiserum. The IFN-α at the doses used did not find any effect on protein synthesis in decidual tissue.

  13. 彩超臀位妊娠与血清HCG关系研究%Study on the Relationship between Ultrasound and Serum HCG of Breech Pregnancy

    Institute of Scientific and Technical Information of China (English)

    廖苏英

    2015-01-01

    目的:通过尿人绒毛膜促性腺激素测定,血清HCG定量测定在正常宫内妊娠,输卵管异位妊娠和妊娠臀位时。方法放射免疫标记血清HCG动态定量测定,每3d用同样的方法进行血清HCG定量测定。200例生育年龄妇女,平均年龄29.8岁,诊断绝经1月后被发现臀位妊娠18例。结果18例停经1个月的臀位妊娠血清hcg定量测定>20mlu辕ml, 20mlu / ml, 38mlu / ml urine determination of < HCG qualitative. Conclusion Color Doppler ultrasound breech pregnancy serum human chorionic gonadotropin (hCG) as a quantitative determination of value than normal pregnancy is low, the ratio of ectopic pregnancy high. according to the clinical manifestations, early diagnosis, to avoid severe complications such as uterine rupture.

  14. Faillure in the effect of the analogue (hCG of luteinizing hormone on the luteal angiogenesis in rats (Rattus novergicus

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    Diego Gonçalves Silva

    2013-04-01

    Full Text Available The knowledge of the mechanisms that affect the control of the ovarian activity is essential for the success of reproduction biotechnologies. Although a number of studies have been carried out in which the luteinizing hormone (LH was used to control the ovarian activity, little is known about its influence in the morphology and vascular formation of the corpus luteum, aiming to increase the local blood flow. Thus, the objective of the present experiment was the quantification of the vascular density of corpora lutea (Cls in animals treated with human chorionic gonadotropin (hCG just after ovulation. Therefore, eighteen wistar rats were used in this experiment. Eight rats in the treated group and ten rats in the control group. Corpora lutea were divided into two groups: group (A treated with hCG in the following morning after copulation, and group (B control animals which received an injection of 0.9% sodium chloride solution. Ovaries from each group were used for preparation of histological sections for vascular density qualification. No statistical significance was found between the two groups tested.

  15. Reducing the trigger dose of recombinant hCG in high-responder patients attending an assisted reproductive technology program: an observational study.

    Science.gov (United States)

    Tiboni, Gian Mario; Colangelo, Enrica Concetta; Ponzano, Adalisa

    2016-01-01

    Decreasing the dose of human chorionic gonadotropin (hCG) used to trigger final oocyte maturation in assisted reproductive technology programs is regarded as a useful intervention in the prevention of ovarian hyperstimulation syndrome, but the minimal effective dose has not been yet identified. In this study, the capacity of a reduced dose of recombinant hCG (r-hCG) to provide adequate oocyte maturation was tested for the first time. Thirty-five high-responder patients received a dose of 125 µg (half of the standard dose) of r-hCG for triggering final oocyte maturation. The number of oocytes retrieved per patient and the proportion of mature oocytes were evaluated. As a result, a mean number of 14 oocytes were retrieved, of which 85% were found to be mature (MII). There was only one patient developing a moderate form of ovarian hyperstimulation syndrome and not requiring hospitalization. It is suggested that r-hCG at 125 µg can be effective in triggering final oocyte maturation in high-responder patients. Additional properly powered and controlled studies are needed to support this contention.

  16. GnRH Agonist Trigger and LH Activity Luteal Phase Support versus hCG Trigger and Conventional Luteal Phase Support in Fresh Embryo Transfer IVF/ICSI Cycles-A Systematic PRISMA Review and Meta-analysis.

    Science.gov (United States)

    Haahr, Thor; Roque, Matheus; Esteves, Sandro C; Humaidan, Peter

    2017-01-01

    The use of GnRH agonist (GnRHa) for final oocyte maturation trigger in oocyte donation and elective frozen embryo transfer cycles is well established due to lower ovarian hyperstimulation syndrome (OHSS) rates as compared to hCG trigger. A recent Cochrane meta-analysis concluded that GnRHa trigger was associated with reduced live birth rates (LBRs) in fresh autologous IVF cycles compared to hCG trigger. However, the evidence is not unequivocal, and recent trials have found encouraging reproductive outcomes among couples undergoing GnRHa trigger and individualized luteal LH activity support. Thus, the aim was to compare GnRHa trigger followed by luteal LH activity support with hCG trigger in IVF patients undergoing fresh embryo transfer. We conducted a systematic review and meta-analysis of randomized trials published until December 14, 2016. The population was infertile patients submitted to IVF/ICSI cycles with GnRH antagonist cotreatment who underwent fresh embryo transfer. The intervention was GnRHa trigger followed by LH activity luteal phase support (LPS). The comparator was hCG trigger followed by a standard LPS. The critical outcome measures were LBR and OHSS rate. The secondary outcome measures were number of oocytes retrieved, clinical and ongoing pregnancy rates, and miscarriage rates. A total of five studies met the selection criteria comprising a total of 859 patients. The LBR was not significantly different between the GnRHa and hCG trigger groups (OR 0.84, 95% CI 0.62, 1.14). OHSS was reported in a total of 4/413 cases in the GnRHa group compared to 7/413 in the hCG group (OR 0.48, 95% CI 0.15, 1.60). We observed a slight, but non-significant increase in miscarriage rate in the GnRHa triggered group compared to the hCG group (OR 1.85; 95% CI 0.97, 3.54). GnRHa trigger with LH activity LPS resulted in comparable LBRs compared to hCG trigger. The most recent trials reported LBRs close to unity indicating that individualization of the LH activity LPS

  17. GnRH Agonist Trigger and LH Activity Luteal Phase Support versus hCG Trigger and Conventional Luteal Phase Support in Fresh Embryo Transfer IVF/ICSI Cycles—A Systematic PRISMA Review and Meta-analysis

    Directory of Open Access Journals (Sweden)

    Thor Haahr

    2017-06-01

    Full Text Available IntroductionThe use of GnRH agonist (GnRHa for final oocyte maturation trigger in oocyte donation and elective frozen embryo transfer cycles is well established due to lower ovarian hyperstimulation syndrome (OHSS rates as compared to hCG trigger. A recent Cochrane meta-analysis concluded that GnRHa trigger was associated with reduced live birth rates (LBRs in fresh autologous IVF cycles compared to hCG trigger. However, the evidence is not unequivocal, and recent trials have found encouraging reproductive outcomes among couples undergoing GnRHa trigger and individualized luteal LH activity support. Thus, the aim was to compare GnRHa trigger followed by luteal LH activity support with hCG trigger in IVF patients undergoing fresh embryo transfer.Material and methodsWe conducted a systematic review and meta-analysis of randomized trials published until December 14, 2016. The population was infertile patients submitted to IVF/ICSI cycles with GnRH antagonist cotreatment who underwent fresh embryo transfer. The intervention was GnRHa trigger followed by LH activity luteal phase support (LPS. The comparator was hCG trigger followed by a standard LPS. The critical outcome measures were LBR and OHSS rate. The secondary outcome measures were number of oocytes retrieved, clinical and ongoing pregnancy rates, and miscarriage rates.ResultsA total of five studies met the selection criteria comprising a total of 859 patients. The LBR was not significantly different between the GnRHa and hCG trigger groups (OR 0.84, 95% CI 0.62, 1.14. OHSS was reported in a total of 4/413 cases in the GnRHa group compared to 7/413 in the hCG group (OR 0.48, 95% CI 0.15, 1.60. We observed a slight, but non-significant increase in miscarriage rate in the GnRHa triggered group compared to the hCG group (OR 1.85; 95% CI 0.97, 3.54.ConclusionGnRHa trigger with LH activity LPS resulted in comparable LBRs compared to hCG trigger. The most recent trials reported LBRs close to unity

  18. Fertilização in vitro com ciclos programados de baixo custo - avaliação de resultados iniciais de um centro de reprodução humana de hospital de ensino In vitro fertilization with low-cost programmed cycles - first outcome in a teaching hospital

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    Nelson Antunes Júnior

    2003-01-01

    Full Text Available OBJETIVOS: avaliação dos resultados iniciais de fertilização in vitro (FIV em instituição universitária, empregando ciclos programados de baixo custo. MÉTODOS: entre maio e dezembro de 2002, foram iniciados 66 ciclos programados de FIV, utilizando acetato de noretisterona, citrato de clomifeno e gonadotrofina coriônica humana (hCG. A punção folicular guiada por ultra-sonografia foi realizada 34 a 36 horas após a administração de hCG e a transferência, 48 horas após a punção. A gestação foi considerada clínica após visualização de batimentos cardíacos à ultra-sonografia transvaginal. RESULTADOS: a taxa de cancelamento foi de 21,2%. Em média, 2,8 folículos e 1,7 oócitos foram obtidos por punção. Em 79,6% dos ciclos puncionados recuperaram-se oócitos, que foram fertilizados em 69% dos casos. O número de embriões por transferência foi de 1,5. Houve algum grau de dificuldade em 10,2% das punções e 32,4% das transferências realizadas. A taxa de gestação obtida foi de 10,8% por transferência, entretanto, o custo com medicação por embrião transferido foi de apenas R$ 96,00. CONCLUSÃO: evidenciam-se as dificuldades de iniciar um programa de FIV em instituição de ensino, sem fins lucrativos e voltada à população carente. Com a prática, a taxa cumulativa de gravidez tende a ser semelhante às dos centros de referência, porém com custo e incidência de complicações significativamente inferiores.PURPOSE: to evaluate the first in vitro fertilization results at a medical university using low-cost programmed cycles. METHODS: from May to December 2002, 66 programmed cycles of in vitro fertilization were carried out using norethisterone acetate, clomiphene citrate and human chorionic gonadotrophin (hCG. The ovarian follicle aspiration was guided by ultrasonography, 34 to 36 h after the administration of hCG, and the embryo transfer, 48 h after puncturing. The diagnosis of clinical pregnancy was defined when a

  19. Fundamentos de la bioética. La calidad de la vida humana

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    Hackspiel Z. Maria Mercedes

    1996-12-01

    Full Text Available

    Human life is the main concern of the fundamental ethic; moreover, life is the ontology problem by excellence. In other words, life is the being absolutely necessary to provide the fundament and condition the possibility for any other idea, value or principle, including of course the human deeds. This is to say there is absolutely nothing that can define human life that is not the own being, the human being is for each individual the totallity of the "I can". The "I can" is in reality an open life and openness is essencially opening to the future. The authentic knowledge of Iife is called understanding, and it is the knowledge of life itself.

    La preocupación ética fundamental es por la vida humana pero además la vida es el problema ontológico por excelencia. Es decir, la vida es el ser absolutamente necesario que sirve de fundamento y condición de posibilidad para toda otra idea, valor o principio, incluyendo naturalmente también los actos. En otras palabras, no hay absolutamente nada que pueda definir a la vida humana que no sea la propia existencia, la existencia humana es para cada individuo la totalidad de los "Yo puedo". El "Yo puedo" es en verdad una vida abierta, y la apertura es esencialmente apertura al futuro. El auténtico conocimiento de la vida se denomina comprensión, y es un conocimiento de la vida por sí misma.

  20. Diagnóstico de la toxocarosis humana Diagnosis of human toxocarosis

    OpenAIRE

    2010-01-01

    La toxocarosis humana es una importante zoonosis parasitaria causada por formas larvarias de especies del género Toxocara, un parásito nematodo de los perros y los gatos. La migración de la larva por los diferentes tejidos blandos en el ser humano genera una serie de entidades clínicas en el paciente, tales como el síndrome de larva migrans visceral, la toxocarosis ocular y la neurotoxocarosis. El diagnóstico definitivo es mediante la histopatología en biopsias, pero resulta ser casi imposibl...

  1. Seguridad humana en Colombia: donde no hay bienestar no puede haber paz

    OpenAIRE

    María Teresa Aya Smitmans

    2006-01-01

    Este artículo trata sobre los retos que amenazan a la soberanía clásica en el sistema internacional y, en especial, a la seguridad humana. Ésta, entendida como una concepción ampliada de la seguridad tradicional, refuerza la idea del individuo como centro de las relaciones internacionales y pone su seguridad por encima de la seguridad estatal. Asimismo, el surgimiento de nuevos actores hacen que la gobernabilidad estatal se vea debilitada a me...

  2. Avança la neurociència cap al control de la ment humana?

    OpenAIRE

    Morgado, Ignacio

    2016-01-01

    L'optogenètica, una tecnologia desenvolupada en els últims deu anys, permet activar o desactivar voluntàriament en temps molt precisos les neurones que fan possible estats mentals particulars. Els seus resultats en la investigació amb rosegadors estan sorprenent als propis científics i el seu desenvolupament en un futur potser no llunyà pot constituir una manera revolucionària de penetració i control del cervell i la ment humana, fet que comporta associat tot un seguit de qüestions ètiques....

  3. de la persona humana en su integridad psicofísica

    Directory of Open Access Journals (Sweden)

    Federico Justiniano Robledo

    2008-01-01

    Full Text Available Este artículo analiza el proceso de reforma constitucional en la órbita provincial, con particular referencia a los límites del Poder Constituyente. Se sostiene que el Poder Constituyente provincial debe preservar los derechos derivados de la dignidad de la persona humana en su integridad psicofísica. Desde esta perspectiva –con miras a futuras reformas constitucionales provinciales– se examina la constitucionalidad de la esterilización a la luz de la Constitución Nacional, tratados internacionales de derechos humanos con jerarquía constitucional, y declaraciones internacionales.

  4. Una apuesta por la comprensión humana en nuestros contextos educativos

    OpenAIRE

    Ceballos Loaiza, Ana Patricia

    2013-01-01

    Tesis (Magister en educación). Universidad Católica de Manizales, Facultad de Educación, 2012 La presente obra, pone en evidencia algunas problemáticas sociales de nuestra realidad actual, que abarcan aspectos desde lo cultural, lo axiológico, lo ecológico, hasta el desarrollo del pensamiento, en aras de potenciar la comprensión humana. El concepto de comprensión – explicación; identificación – proyección han convocado ciertos autores, que se han preocupado por indagar las causalidades de ...

  5. Formación humana en la universidad. Retos y posibilidades

    OpenAIRE

    Patricia Muriel Rojas, Claudia; Universidad de San Buenaventura Cali

    2013-01-01

    El presente artículo parte de la reflexión sobre algunas representaciones dominantes en la formación universitaria relacionadas con la separación de la formación humana respecto a la formación disciplinar y con la construcción de lugares comunes desde el consenso. Se resalta el lugar de la formación universitaria como espacio de agenciamiento social para posteriormente abordar los retos de esta formación considerando las persistencias de la modernidad que la impactan. Finalmente, el artículo ...

  6. Por una comprensión adecuada de la dignidad humana

    Directory of Open Access Journals (Sweden)

    Krystian Complak

    2005-01-01

    Full Text Available Existe un cierto número de lugares comunes sobre la dignidad humana que hacen necesario distinguir entre dignidad personal (vinculada solo con un individuo determinado y dignidad ontológica (ligada además o antes que nada con el género humano. La primera es subjetiva y relativa, la segunda objetiva y absoluta. En otras palabras, la primera es independiente de la autovaloración que uno posee acerca de sí mismo. Todo examen de la dignidad debe partir de una definición del ser humano y la más apropiada es la surgida del enfoque cristiano del hombre como algo excepcional dentro de la naturaleza, a diferencia de otras concepciones que lo relativizan demasiado y por eso no son convenientes para plantear la dignidad humana como categoría incondicional. En este orden de ideas, no es fácil infringir la dignidad en cuestión. Para quebrantarla, se debe arrematar al hombre como representante de la raza humana. El acuerdo del individuo para acometer tal hecho está excluido. La dignidad humana es siempre de talante defensivo. Ella protege al hombre contra una violación de lo que es más humano en él. Por eso, hay que separarla de la libertad. A pesar de la conexión entre ambas categorías no se pueden equiparar. La persona es digna por cuanto es libre, pero no existe una dependencia en el sentido contrario. La dignidad es omnímoda. En caso de colisión entre esta y la libertad de palabra, cabe dar siempre la primacía al respeto por la primera. Por otro lado, es importante destacar que la dignidad nada tiene que ver con la calidad de vida; ya que en ese caso sería solo pertinente a quienes gozan de un elevado nivel del bienestar material, no a los pobres.

  7. Propiedades mecánicas de la dentina humana Mechanical properties of human dentin

    Directory of Open Access Journals (Sweden)

    Mª V. Fuentes Fuentes

    2004-04-01

    Full Text Available Puesto que la dentina es el mayor constituyente de la estructura dental, su microestructura y sus propiedades son los principales determinantes en casi todos los procedimientos de Odontología restauradora. Este artículo trata de las siguientes propiedades mecánicas de la dentina humana: la resistencia cohesiva, la microdureza y el módulo de elasticidad.Since dentin is the major constituent of the teeth, dentin microstructure and their properties are principal determinants of nearly all procedures in restorative dentistry. This paper is about following mechanical properties of human dentin: cohesive strength, microhardness and modulus of elasticity.

  8. Métodos de análise da severidade da patologia da marcha humana

    OpenAIRE

    Vieira, Alexandra Sofia Domingues

    2015-01-01

    A marcha humana é composta por um conjunto de movimentos complexos que dificultam a sua análise e o reconhecimento de padrões de marcha normais ou patológicos. O presente relatório descreve o projeto desenvolvido com o objetivo de apresentar dois métodos, capazes de avaliar a severidade da patologia de marcha e auxiliar a análise médica: análise cinética e análise cinemática. Na primeira fase do projeto foi escrita e submetida uma patente que descreve um sapato instrumentado, capaz de real...

  9. Evolución y emergencia de algunas enfermedades animales y humanas

    OpenAIRE

    Blancou, Jean M.

    2000-01-01

    La atención de la opinión pública está particularmente centrada desde hace unos años en la evolución de las enfermedades animales y humanas que pueden entrañar un riesgo sanitario. Aunque ese riesgo se ha exagerado considerablemente, si se compara con el que siempre ha existido en nuestro planeta, no debe sin embargo ser ignorado. En realidad, ese riesgo se basa en una tendencia a la evolución de los agentes patógenos que se observa actualmente, tanto en medicina veterinaria como en...

  10. Escuela de relaciones humanas y su aplicación en una empresa de telecomunicaciones

    OpenAIRE

    Ramos Lugo, Gloria Enith; Triana Gómez, Martha Lucía

    2007-01-01

    Este documento presenta un análisis sobre la forma como influyeron algunos conceptos estudiados en la Escuela de Relaciones Humanas de Elton Mayo, en la administración de la Empresa Nacional de Telecomunicaciones de Colombia - Telecom, hoy reestructurada en la nueva organización llamada “Colombia Telecomunicaciones”, para el logro de sus objetivos dentro de un nuevo entorno competitivo y con nueva regulación en el sector de la telecomunicaciones. Así mismo se pretende dar una mirada crítica a...

  11. Papel de gestión humana en procesos de flexibilidad funcional en empresas colombianas

    OpenAIRE

    Cuervo Aullon, Mónica; Martínez Salazar, Pahola Mercedes; Yucuma Guzmán, Marcia Andrea

    2014-01-01

    Tesis (Maestría en Gerencia del Talento Humano). Universidad de Manizales. Facultad de Ciencias Sociales y Humanas, 2014 La flexibilidad funcional se refiere a la capacidad de una empresa para utilizar eficazmente su fuerza de trabajo variando la labor que desempeña ante modificaciones en el volumen de trabajo y las posibilidades que ofrecen las nuevas tecnologías. Se realiza el presente estudio de corte cualitativo en 39 medianas y grandes empresas de servicios colombianas del sector indu...

  12. A dignidade humana como afirmação histórica

    Directory of Open Access Journals (Sweden)

    Afonso Soares Oliveira Sobrinho

    2013-04-01

    Full Text Available Vivenciamos um mundo em que o econômico se sobrepõe ao político e as desigualdades sociais e culturais são tão marcantes e prevalece o consumismo sobre a vida tornando-a banal. A afirmação histórica da dignidade da pessoa humana como dimensão de direitos faz-se mister na busca pela efetividade dos direitos sociais no novo constitucionalismo.

  13. Relevancia e Inferencia: Procesos cognitivos propios de la comunicación humana

    Directory of Open Access Journals (Sweden)

    Constanza Moya Pardo

    2006-06-01

    Full Text Available Este artículo pretende mostrar los planteamientos cognitivos más representativos de la Teoría de la Relevancia propuesta por Spelber & Wilson con respecto al modelo ostensivo-inferencial. Este modelo plantea un mecanismo deductivo explícito que da cuenta de los procesos y estrategias que permiten el paso del significado literal a la interpretación pragmática de los mensajes en el proceso de comunicación humana.

  14. A psicologia face aos novos progressos da genética humana

    OpenAIRE

    Rossano André Dal-Farra; Emerson Juliano Prates

    2004-01-01

    Os avanços da Genética contemporânea têm suscitado uma grande polêmica a respeito da gênese do homem e das possibilidades de agir sobre a biologia humana, repercutindo intensamente sobre os mais diversos ramos do conhecimento. Considerando a importância do tema, este texto pretende apresentar de forma sucinta os principais resultados de pesquisas sobre as bases genéticas do comportamento humano, com o foco voltado para a importância do profissional de Psicologia em questões relativas ao assun...

  15. La conducta simbólica humana : nueva orientación metodológica

    OpenAIRE

    Ángel RIVERA ARRIZABALAGA

    2004-01-01

    El presente trabajo constituye un intento de análisis de la conducta simbólica humana, por medio de una síntesis metodológica elaborada con las aportaciones de varias ciencias relacionadas con los seres humanos (Arqueología, Biología evolutiva, Neurología, Psicología y Sociología). El resultado es un modelo Psicobiológico sobre el comportamiento humano en todas sus fases de evolución cultural. Su desarrollo facilita el inicio de una nueva vía explicativa sobre el origen y evolución ...

  16. Disfunción tiroidea en adultos infectados por el virus de inmunodeficiencia humana

    OpenAIRE

    Erika Abelleira; Graciela A De Cross; Fabián Pitoia

    2014-01-01

    Los pacientes con infección por el virus de inmunodeficiencia humana (HIV) tienen una mayor prevalencia de disfunción tiroidea cuando se los compara con la población general. Las manifestaciones más frecuentemente observadas son: el síndrome del eutiroideo enfermo, la enfermedad de Graves y el hipotiroidismo subclínico. La relación entre el uso de la terapia antirretroviral y el incremento en la prevalencia de alteraciones tiroideas fue demostrada en varias series de pacientes. La enfermedad ...

  17. Métodos de gene tangeting en células humanas

    OpenAIRE

    Bernardi, María Alejandra

    2012-01-01

    Se diseñaron plásmidos, con los cuales fue posible obtener vectores AAV recombinantes (virus adenoasociados recombinantes) con el fin de aumentar la recombinación homóloga en células humanas y generar una modificación génica en un sitio de interés en el genoma humano. Esto se ha conseguido de manera efectiva, aunque la frecuencia de recombinación homóloga sigue siendo aún muy baja.

  18. Expressões faciais e emoções humanas levantamento bibliográfico

    Directory of Open Access Journals (Sweden)

    Josinete Aparecida da Silva

    1995-06-01

    Full Text Available Este trabalho tem por objetivo registrar um levantamento bibliográfico feito nas áreas de conhecimento de Enfermagem e Psicologia, sobre as expressões faciais e as emoções humanas. Visa auxiliar os profissionais de saúde a refletirem sobre a importância da face nas relações interpessoais, mostrando as pesquisas mais citadas em bibliografia específica, primeiro referente às crianças e depois aos adultos.

  19. El desarrollo como estrategia adaptativa: características exclusivas de la infancia humana

    OpenAIRE

    Español, Silvia

    2010-01-01

    En este trabajo se presenta una hipótesis evolucionista acerca del desarrollo. Se compara la infancia humana con la de los primates no humanos y se describen sus rasgos exclusivos vinculados con la extensión y transformación del mundo emocional, la interacción adulto-bebé y la formación de procesos psicológicos complejos. Se argumenta a favor del papel constitutivo de las artes temporales en cada uno de los rasgos descriptos. This paper introduces an evolutionary hypothesis about developme...

  20. El desarrollo local a escala humana: experiencias de desarrollo comunitario en el sector salud. Chile

    OpenAIRE

    Peroni, Andrea

    2012-01-01

    El desarrollo local es controversial por  las limitaciones en las que se encuentra inserto. Por un lado la globalización arrasante y el crecimiento económico sin vinculación con la ética. Por otro lado, la falta de autonomía local y la desvinculación de las comunidades con los proyectos de desarrollo de mayor alcance. Dichas tensiones, invitan a cruzar fronteras y a pensar el desarrollo local a escala humana, como modelo orientador,  como germen de otra mirada del desarrollo humano. En el pre...

  1. La comunicación humana como objeto semiótico, una tarea en estudio

    OpenAIRE

    Riestra, Dora

    2007-01-01

    En la cultura occidental las relaciones entre las nociones y representaciones de lengua, lenguaje y pensamiento humanos han ido cambiando a lo largo de los siglos. En el transcurso del siglo XX, de los cruces producidos entre las teorías funcionalistas y los enfoques cognitivos en las teorías lingüísticas, las nociones de texto y discurso se resituaron como centro de la actividad comunicativa humana; al mismo tiempo, los enfoques pragmáticos fueron centrándose en nuevos objetos de investigaci...

  2. EL PRINCIPIO DE LA DIGNIDAD HUMANA COMO FUNDAMENTO DE UN BIODERECHO GLOBAL

    Directory of Open Access Journals (Sweden)

    Ángela Aparisi Miralles

    2013-01-01

    Full Text Available El término dignidad posee muchos significados. Ello se debe a que designa una realidad muy rica, que puede ser contemplada desde diversas perspectivas. Entre dichas acepciones, destaca la que entiende la dignidad como un principio ético-jurídico, fundamento de la bioética y el bioderecho. El objetivo de este trabajo es aproximarnos, muy someramente, a dicho sentido. Para ello, se expondrán, brevemente, las concepciones personista y utilitarista del mismo. Finalmente, y como alternativa a las insuficiencias de estas visiones, se propone la concepción ontológica de la dignidad humana.

  3. La seguridad humana. De la seguridad de los Estados a la seguridad de las personas

    OpenAIRE

    2015-01-01

    La Seguridad humana es un término relativamente reciente acuñado por vez primera en el Informe sobre desarrollo humano del PNUD (Programa de las Naciones Unidas para el Desarrollo) de 1994. Este concepto trata de cambiar el concepto de seguridad tradicional enfocado hacia la protección del Estado frente a cualquier ataque a su soberanía, para tratar de enfocar la seguridad hacia la protección del individuo en cualquier ámbito de la vida, consiguiendo esto a través del desarrollo humano, térmi...

  4. Mejora humana y dopaje en la actual filosofía del deporte

    OpenAIRE

    lópez Frías, Francisco Javier

    2014-01-01

    Esta tesis parte del hecho de que resulta esencial realizar una reflexión crítica sobre el deporte. Éste no sólo ejemplifica algunas de las características y capacidades que consideramos como más propiamente humanas, sino que los seres humanos que nos vemos relacionados con el deporte nos hacemos a través de él. Esto ha sido una constante a lo largo de la Historia. No hay más que ver que todas las civilizaciones anteriores a la nuestra han tenido una actividad deportiva que ha resultado centr...

  5. Zur Genese der niederländischen Typoxylographien des Speculum humanae salvationis

    DEFF Research Database (Denmark)

    Robbe, Joost Roger

    2013-01-01

    This article aims to reconstruct the genesis of the four typo-xylographic editions of the Speculum Humanae Salvationis (two in Latin and two in Dutch), which, from the 16th century onwards, have informed the debate on the origin of printing. The article first summarises the relevant philological...... and appealing to material evidence, this article presents a coherent picture of the genesis of the typo-xylographic works. It refines Stevenson’s dating of the editions, and offers more evidence for the dual-workshop thesis. Finally, this article puts forward the hypothesis that the original blockbook plans...

  6. Formación humana en la universidad. Retos y posibilidades

    OpenAIRE

    Patricia Muriel Rojas, Claudia; Universidad de San Buenaventura Cali

    2013-01-01

    El presente artículo parte de la reflexión sobre algunas representaciones dominantes en la formación universitaria relacionadas con la separación de la formación humana respecto a la formación disciplinar y con la construcción de lugares comunes desde el consenso. Se resalta el lugar de la formación universitaria como espacio de agenciamiento social para posteriormente abordar los retos de esta formación considerando las persistencias de la modernidad que la impactan. Finalmente, el artículo ...

  7. Manifestaciones orales y caries dental en niños expuestos al virus de inmunodeficiencia humana

    OpenAIRE

    Dávila L, María Elena; Gil M, Maritza A

    2012-01-01

    Objetivo Determinar las manifestaciones orales y caries dental en niños expuestos al virus de inmunodeficiencia humana (VIH). Métodos Se estudiaron 37 niños que acuden a la consulta pediátrica del programa nacional  de control de SIDA (PRONASIDA-Lara). Se informó a padres y representantes sobre los objetivos del estudio y su carácter confidencial. El examen de la cavidad oral lo realizó un odontólogo, quien además indagó sobre historia de manifestaciones bucales y corroboró la información con...

  8. Mejora humana y dopaje en la actual filosofía del deporte

    OpenAIRE

    López Frías, Francisco Javier

    2014-01-01

    Esta tesis parte del hecho de que resulta esencial realizar una reflexión crítica sobre el deporte. Éste no sólo ejemplifica algunas de las características y capacidades que consideramos como más propiamente humanas, sino que los seres humanos que nos vemos relacionados con el deporte nos hacemos a través de él. Esto ha sido una constante a lo largo de la Historia. No hay más que ver que todas las civilizaciones anteriores a la nuestra han tenido una actividad deportiva que ha resultado centr...

  9. Competencias distintivas en las pymes: un aporte desde gestión humana

    OpenAIRE

    Gregorio Calderón Hernández

    2006-01-01

    Con el fin de establecer de qué manera se está apoyando la competitividad por parte de la gestión humana en las pymes, se adelantó una investigación en 16 pequeñas y medianas unidades productivas de Manizales, en donde se estudiaron las competencias distintivas que más inciden sobre los factores de competitividad empresarial. Desde el punto de vista teórico se tomaron el enfoque sistémico de la competitividad, la teoría de recursos y capacidades, y la perspectiva estratégica de la gestión hum...

  10. Propuesta de un modelo de gestión humana y cultura organizacional para pymes innovadoras

    OpenAIRE

    Pérez Uribe, Rafael Ignacio

    2013-01-01

    La gestión humana y cultura organizacional son conceptos inseparables en cualquier tipo de organización y han sido tratados extensamente en el ámbito académico general, pero no en el caso de las PyMES. Las condiciones sociales, económicas y culturales de este nuevo siglo hacen imprescindible que las empresas medianas y pequeñas sean altamente creativas, innovadoras, se adapten ágilmente a los cambios, sobrevivan y crezcan, y para lograrlo necesariamente deben contar con una fuerza laboral com...

  11. A psicologia face aos novos progressos da genética humana

    OpenAIRE

    Rossano André Dal-Farra; Emerson Juliano Prates

    2004-01-01

    Os avanços da Genética contemporânea têm suscitado uma grande polêmica a respeito da gênese do homem e das possibilidades de agir sobre a biologia humana, repercutindo intensamente sobre os mais diversos ramos do conhecimento. Considerando a importância do tema, este texto pretende apresentar de forma sucinta os principais resultados de pesquisas sobre as bases genéticas do comportamento humano, com o foco voltado para a importância do profissional de Psicologia em questões relativas ao assun...

  12. Anticorpos específicos para a criptosporidiose humana detectados mediante imunofluorescência indireta

    OpenAIRE

    1996-01-01

    Utilizando a técnica de imunofluorescência indireta, foram demonstradas imunoglobulinas G e M, no soro humano, contra o Cryptosporidium, coccídeo implicado recentemente como agente de doença intestinal humana, principalmente em pacientes imunocomprometidos. Foi obtida positividade de 62% para imunoglobulinas G e M nos soros das crianças immunocompetentes com oocistos nas fezes e, respectivamente, 20% e 40%, nos soros das crianças sem oocistos. Nos pacientes adultos , com o vírus da imunodefic...

  13. Myiasis gastrointestinal humana por Eristalis tenax Gastrointestinal human myiasis for Eristalis tenax

    Directory of Open Access Journals (Sweden)

    Marcelo Kun

    1998-08-01

    Full Text Available Son caracterizadas las myiasis registradas en Bariloche y establecidas las condiciones probables bajo las cuales se produjeron las infestaciones. Las larvas obtenidas a partir de heces de 2 pacientes fueron identificadas como Eristalis tenax (Diptera: Syrphidae de acuerdo a las claves de Hartley (1961 y Organización Panamericana de la Salud (1962. Estos 2 casos de myiasis gastrointestinal humana constituyen los primeros registrados en Bariloche (Patagonia, Argentina y sus características responden a las registradas para esta especie de Díptera en otras partes del mundo. La falta de control específico en el sistema domiciliario de suministro de agua ha sido la causa más probable de la infestación. Este registro extiende la distribución de E. tenax y de las myiasis gastrointestinales humanas en América del Sur hasta los 41º 03' S.Foram caracterizadas as miasis registradas em Bariloche (Patagonia, Argentina e estabelecidas as prováveis condições sob as quais são produzidas as infestações. As larvas obtidas a partir das fezes de dois pacientes foram identificadas como Eristalis tenax (Diptera: Syrphdae. Esses dois casos de miasis gastrointestinal humana foram os primeiros registrados em Bariloche, Argentina, e suas características respondem às registradas para esta espécie de Diptera em outras partes do mundo. A falta de controle específico no sistema domiciliário de abastecimento de água tem sido a causa mais provável de infestação. Este registro amplia a distribuição de E. tenax e das miasis gastrointestinais humanas em América do Sul até os 41º 03's.The myiasis observed in Bariloche are characterized and the probable conditions under which the infestations took place established. The larvae obtained from faeces of 2 patients were identified as Eristalis tenax (Diptera: Syrphidae according to Hartley (1961 and Organización Panamericana de la Salud keys (1962. These 2 cases of human gastrointestinal myiasis were the

  14. Genetica Humana

    Directory of Open Access Journals (Sweden)

    CarloAlberto Redi

    2015-02-01

    Full Text Available Sometimes we do not realize that Spanish speaking people are one of the major linguistic group on our planet! Thus we have to welcome this excellent book devoted to, as the title clearly tell us, human genetics for the pleasure of the Spanish speaking people. Those who love genetics, young fellows at the beginning of their careers, esteemed professors and historians of science will get for the affordable price.....

  15. Differences in signal activation by LH and hCG are mediated by the LH/CG receptor`s extracellular hinge region

    Directory of Open Access Journals (Sweden)

    Paul eGrzesik

    2015-09-01

    Full Text Available The human lutropin/choriogonadotropin receptor (LHCGR can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG - secreted by the placenta, and lutropin (LH - produced by the pituitary. They induce different signaling profiles at the LHCGR. This cannot be explained by binding to the receptor's leucine-rich repeat domain (LRRD, as this binding is similar for the two hormones. We therefore speculate that there are previously unknown differences in the hormone/receptor interaction at the extracellular hinge region, which might help to understand functional differences between the two hormones. We have therefore performed a detailed study of the binding and action of LH and CG at the LHCGR hinge region. We focused on a primate-specific additional exon in the hinge region, which is located between LRRD and the serpentine domain. The segment of the hinge region encoded by exon10 was previously reported to be only relevant to hLH signaling, as the exon10-deletion receptor exhibits decreased hLH signaling, but unchanged hCG signaling. We designed an advanced homology model of the hormone/LHCGR complex, followed by experimental characterization of relevant fragments in the hinge region. In addition, we examined predictions of a helical exon10-encoded conformation by block-wise polyalanine (helix supporting mutations. These helix preserving modifications showed no effect on hormone induced signaling. However, introduction of a structure-disturbing double-proline mutant LHCGR-Q303P/E305P within the exon10-helix has, in contrast to exon10 deletion, no impact on hLH, but only on hCG signaling. This opposite effect on signaling by hLH and hCG can be explained by distinct sites of hormone interaction in the hinge region s. In conclusion, our analysis provides details of the differences between hLH- and hCG-induced signaling that are mainly determined in the L2-beta loop of the hormones and in the hinge region

  16. Efectos para Colombia de los debates en torno a la seguridad del Estado y a la seguridad humana

    Directory of Open Access Journals (Sweden)

    Diana Mejía Molina

    2009-06-01

    Full Text Available Desde la última década del siglo xx ha tomado fuerza el concepto de seguridad humana como alternativa a la idea clásica de seguridad estatal, con lo cual se ha intentado darle mayor consideración a la obligación de los Estados de hacer respetar los derechos humanos dentro de su territorio. Sin embargo, tras el 11 de septiembre de 2001 la seguridad estatal ha vuelto a tomar protagonismo, sin que esto signifique la desaparición política de la seguridad humana. Este artículo explora el significado de estos dos conceptos y plantea una reflexión sobre la importancia actual de la idea de seguridad humana para Colombia.

  17. LA PERCEPCIÓN MEDIOAMBIENTAL DEL PROFESORADO DE PRIMARIA EN EL TEMA DE LA NUTRICIÓN HUMANA

    Directory of Open Access Journals (Sweden)

    Susana García Barros

    2010-01-01

    Full Text Available En este trabajo se muestra como un proyecto de tesis doctoral, dirigido a estudiar el pensamiento del profesorado de educación primaria en ejercicio y en formación sobre la nutrición humana, se acerca a la problemática ambiental. En el artículo se justifica la dimensión medioambiental de la nutrición humana que sirve de referencia para las decisiones tomadas en la metodología planteada. Así mismo se presentan unos primeros resultados, que aunque todavía limitados, ponen de manifiesto que la sensibilidad ambiental del profesorado en formación con relación al tema de la nutrición humana es inferior a lo deseable.

  18. Human chorionic gonadotropin (hCG) regression normograms for patients with high-risk gestational trophoblastic neoplasia treated with EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine) chemotherapy

    NARCIS (Netherlands)

    Lybol, C.; Westerdijk, K.; Sweep, F.C.; Ottevanger, P.B.; Massuger, L.F.A.G.; Thomas, C.M.G.

    2012-01-01

    Background We present normograms for human chorionic gonadotropin (hCG) regression in patients with high-risk gestational trophoblastic neoplasia (GTN) successfully treated with multiagent chemotherapy in order to predict treatment resistance. Patients and methods We collected data for 46 patients w

  19. Measurement of plasma human chorionic gonadotropin (hCG) and beta-hCG activities in the late luteal phase: evidence of the occurrence of spontaneous menstrual abortions in infertile women.

    Science.gov (United States)

    Chartier, M; Roger, M; Barrat, J; Michelon, B

    1979-02-01

    Plasma luteinizing hormone (LH-human chorionic gonadotropin (hCG) and beta-hCG activities were measured during the late luteal phase in 321 cycles of 147 infertile women. In 71 cycles the hCG measurement permitted the diagnosis of pregnancy between the 10th and 14th days after the thermal nadir. The slope of the regression line derived from hCG levels during the first 22 days of pregnancy was significantly lower in pregnancies which aborted before the 60th day than in normal pregnancies (P less than 0.01). Among 72 cycles ended by apparently normal menses which exhibited an LH-hCG activity at least equal to 7 mIU of hCG/ml during the late luteal phase, the beta-hCG activity was measured in 49 cycles during which hCG had not been given. Significant beta-hCG activity (greater than or equal to 4 mIU of hCG/ml) was detected in 19 cases. This finding supports the assumption that secretory trophoblastic tissue had been present and that spontaneous menstrual abortions had occurred in these women.

  20. Importância do zinco na nutrição humana

    Directory of Open Access Journals (Sweden)

    Mafra Denise

    2004-01-01

    Full Text Available Recentes pesquisas experimentais e clínicas têm reforçado a importância do zinco na saúde humana. O zinco possibilita várias funções bioquímicas, pois é componente de inúmeras enzimas, dentre estas, álcool desidrogenase, superóxido dismutase, anidrase carbônica, fosfatase alcalina e enzimas do sistema nervoso central. Participa na divisão celular, expressão genética, processos fisiológicos como crescimento e desenvolvimento, na transcrição genética, na morte celular, age como estabilizador de estruturas de membranas e componentes celulares, além de participar da função imune e desenvolvimento cognitivo. Sua deficiência pode causar alterações fisiológicas como, hipogonodismo, danos oxidativos, alterações do sistema imune, hipogeusia, danos neuropsicológicos e dermatites. Assim, devido a inúmeras pesquisas referentes a este mineral, este trabalho teve como objetivo mostrar os aspectos atuais sobre a essencialidade do zinco na nutrição humana.

  1. Percepções Acadêmicas sobre o Ensino e a Aprendizagem em Anatomia Humana

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    Cléton Salbego

    Full Text Available Esta pesquisa investiga as percepções de acadêmicos sobre o processo de ensino e aprendizagem na disciplina de Anatomia Humana oferecida nos cursos de Ciências Biológicas e Enfermagem de uma universidade da Região Centro-Oeste do Estado do Rio Grande do Sul. Trata-se de uma pesquisa qualitativa, com caráter descritivo e exploratório, realizada com dez acadêmicos de cada um dos cursos envolvidos, regularmente matriculados na disciplina e frequentando o Laboratório de Anatomia Humana. Os depoimentos foram coletados por meio de entrevistas semiestruturadas e analisados à luz da análise de conteúdo. Emergiram percepções acerca do processo de ensino e aprendizagem da disciplina e da sua relevância para a formação profissional. Conclui-se que as percepções dos acadêmicos apontam obstáculos enfrentados para uma aprendizagem efetiva. As dificuldades despertam nos estudantes sentimentos de impotência e desânimo. Nesse contexto, surge um grande desafio: propor estudos que considerem a opinião dos acadêmicos, promovendo espaços de troca e construção coletiva do processo de formação.

  2. Bartonelosis humana: antes y después de Daniel Alcides Carrión

    Directory of Open Access Journals (Sweden)

    Juan Takano Morón

    Full Text Available La presente es una revisión de los aspectos bibliográficos relacionados con el conocimiento de la bartonelosis humana antes y después de la muerte de Daniel Alcides Carrión. Se enfatiza el estímulo que significó el sacrificio de Carrión en el desarrollo de la investigación médica en el Perú, en especial en lo referente a la bartonelosis humana, realizada por investigadores peruanos y de otras partes del mundo. La revisión incluye al área básica del conocimiento sobre la bacteria causante del proceso mórbido, la respuesta del huésped a la infección así como en el comportamiento bifásico de la enfermedad. La bibliografía revisada incluye aportes al conocimiento de la enfermedad, conocida hoy con el epónimo de “Enfermedad de Carrión”, a lo largo de más de un siglo de historia

  3. O parentesco como consciência humana: o caso dos piro

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    Gow Peter

    1997-01-01

    Full Text Available Este artigo analisa o sistema de parentesco dos Piro da Amazônia peruana como um sistema autopoiético, isto é, como um sistema que gera suas próprias condições de existência. O postulado teórico central é que o parentesco é um sistema de subjetividade, pois as estruturas básicas da consciência humana envolvem necessariamente a consciência de um eu em meio aos outros. Um dos objetivos aqui perseguidos é o de contribuir para que a antropologia simbólica possa voltar a fazer um uso fecundo da noção de "natureza humana". A análise parte de uma narrativa, "O Nascimento de Tsla", em que se encontram encapsulados - na mensagem como nas condições pragmáticas de enunciação desse mito - os princípios fundamentais do parentesco piro, acompanhando a ontogênese dos seres humanos e mostrando o papel constitutivo, nessa ontogênese, da linguagem e da alteridade.

  4. La reproducción humana asistida en el contexto de los derechos humanos

    Directory of Open Access Journals (Sweden)

    Maria Olga Sánchez Martínez

    2013-12-01

    Full Text Available Al abordar la legislación sobre Reproducción Humana Asistida, el legislador realiza una labor de mediación entre distintos derechos y principios que, en su pretensión de justicia, no está exenta de controversia. Tal labor no se realiza desde un punto de vista neutral, se han de tener en cuenta distintas opciones éticas e ideológicas propias de una sociedad democrática, sin abandonar la coherencia con el desarrollo de los distintos derechos humanos en juego, en definitiva, esa ética pública que configura los sistemas culturales, sociales y políticos: el derecho a la vida, a la dignidad, al libre desarrollo de la personalidad, a fundar una familia, a la intimidad personal y familiar, a la identidad, a la maternidad, a la salud, a la producción y creación científica y a gozar de los beneficios del progreso científico. Algunas Sentencias del Tribunal Europeo de Derechos Humanos y de la Corte Interamericana de Derechos Humanos inciden en estos derechos al tratar las Reproducción Humana Asistida, lo cual permite, más allá de las legislaciones concretas, esbozar algunos consensos sobre unas técnicas en constante evolución, como las sociedades en las que tales técnicas se ponen a disposición de sus ciudadanos.

  5. Gestão Ambiental nas Organizações Humanas

    Directory of Open Access Journals (Sweden)

    Jefferson de Queiroz Crispim

    2003-05-01

    Full Text Available Este artigo pretende abordar os conceitos e aplicabilidade da Gestão Ambiental nas Organizações Humanas. Parte de algumas premissas teóricas de interdisciplinaridade que fundamentam as ciências da administração, da economia e da pedagogia humana nas empresas, que possibilitam a ação eficaz na rede sistêmica da vida organizacional. Sabe-se, que a construção do conhecimento organizacional fundamenta-se na própria reconstrução do conhecimento, onde a interdisciplinaridade das Ciências Naturais e Socais é condição “sine qua mon”, para que este entendimento se fortaleça, quando dirigida para a aplicabilidade coletiva das vidas das empresas. Serão analisados os aspectos relacionados com origem do movimento capitalista, as estratégias de organização e a relação com a natureza, bem como a organização social e reconstrução das relações sócias entre empresas, sociedade e mercado.

  6. Intencionalidade em tomasello, searle, dennett e em abordagens comportamentais da cognição humana

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    Sylvio Állan

    Full Text Available A abordagem de Tomasello da evolução da cognição humana busca integrar processos biológicos, comportamentais e culturais em um mesmo sistema explicativo. No entanto, uma das principais críticas a essa abordagem é a necessidade de uma melhor elaboração do conceito de intencionalidade. O objetivo do presente trabalho foi: (1 analisar o tratamento de Tomasello do conceito de intencionalidade; e (2 estabelecer interlocuções desse tratamento com teorias da intencionalidade na filosofia da mente e com abordagens funcionalistas da cognição humana na psicologia comportamental. Sugerimos que o tratamento do conceito de intencionalidade na abordagem de Tomasello é compatível com essas teorias e abordagens. Além disso, a abordagem de Tomasello pode ampliar a investigação de processos simbólicos mais complexos do que aqueles tradicionalmente investigados pela psicologia comportamental.

  7. BENEFÍCIOS DA BIOMASSA DE BANANA VERDE Á SAÚDE HUMANA

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    Vânia Thais Silva Gomes

    2017-03-01

    Full Text Available Este estudo tem por objetivo contextualizar os benefícios da biomassa de banana verde na saúde humana. A pergunta norteadora para a construção desta revisão integrativa foi: qual os benefícios da biomassa de banana verde para a saúde humana? Para a seleção dos estudos, utilizou-se as seguintes bases de dados eletrônicas: SCIELO (Scientific Eletronic Library Online, IBECS (Indice Bibliográfico Español de Ciencias de la Salud, LILACS (Literatura LatinoAmericana e do Caribe em Ciências da Saúde e MEDLINE (Medical Literature Analysis and Retrieval System Online. Concluiu-se que a biomassa da banana verde apresenta uma boa quantidade de nutrientes, vitaminas, fibras, o preparo é rápido e fácil, e o custo é acessível. É considerado um alimento funcional, pois apresenta prebióticos, amido resistente em sua composição, portanto considerada uma ótima fonte de nutrientes.

  8. Tela, piel, color: retratando los mercados de las Antillas como un inventario de la diversidad humana

    Directory of Open Access Journals (Sweden)

    Anne Lafont

    2016-07-01

    Full Text Available La confrontación de las poblaciones heterogéneas y de razas mixtas en las Indias Occidentales con el material pictórico (lienzo y pigmentos y los sistemas de clasificación humana propios de la era de las ilustraciones de la Enciclopedia, demuestra ser un campo de investigación notablemente interesante en términos de raza y el proceso de racialización,. Sin embargo, hasta hoy, la idea de pintura caribeña de la modernidad temprana no se ha presentado como tal, y esto es precisamente lo que propongo estudiar en este artículo. En efecto, la pintura caribeña, a partir de la creatividad figurativa y sus raíces en la especificidad geográfica, política e histórica de este archipiélago racial y cultural, creó un inventario pictórico original de la diversidad humana.

  9. Sexualidade humana na formação do enfermeiro Sexualidad humana en la formación del enfermero Human sexuality in nurses' formation

    Directory of Open Access Journals (Sweden)

    Elucir Gir

    2000-04-01

    Full Text Available Aplicou-se um questionário aos alunos do curso de graduação em Enfermagem, com o objetivo de se verificar as noções que estes sujeitos apresentam acerca da temática sexualidade, no término do curso de graduação, bem como identificar alguns temas da sexualidade vivenciados por ocasião de suas atividades acadêmicas. Os resultados mostraram que os alunos apresentam, em sua maioria, noções fluídas e limitadas, sem embasamento norteador sobre sexualidade humana, além de empregarem os termos "sexo" e "sexualidade" como sinônimos. Os alunos referem ter necessidade de adquirir conhecimento sobre sexualidade. Apresenta-se, ainda, a classificação do embasamento recebido, as disciplinas do curso de graduação que viabilizaram discussões e as situações-tema enfrentadas ou abordadas nas atividades acadêmicas.Se aplicó un cuestionario a los alumnos del curso de pre-grado en enfermería, en el término del mismo, con el objetivo de verificar las acciones que estos sujetos presentan acerca de la temática de sexualidad, y también identificar algunos temas de la sexualidad vividos en sus actividades académicas. Los resultados demostraron que los alumnos presentan, en su mayoría, nociones fluidas y limitadas, sin una base de orientación sobre la sexualidad humana, además de usar el término "sexo" y "sexualidad" como sinónimos. Los alumnos refieren necesidad en adquirir conocimientos sobre sexualidad. Se presenta, además, la clasificación del conocimiento previo recibido, las asignaturas del curso de pre-grado que permitieron discusiones y las situaciones-tema enfrentadas y/o abordadas en las actividades académicas.A questionnaire was applied to undergraduate nursing students in order to verify the ideas on the sexuality theme they had absorbed from the notions they received in their nursing undergraduate program. Results showed that most of these students have slightly, limited and unbased notions concerning human sexuality. They

  10. Paz y seguridad humana en África: una visión desde la Unión Africana

    OpenAIRE

    Jerónimo Delgado

    2009-01-01

    En este artículo se analizan las diferentes iniciativas que ha tenido el continente africano en materia de solución de conflictos y consolidación de la paz desde la perspectiva de la seguridad humana. En la primera parte, se identifican los componentes de la seguridad humana y los factores de inseguridad a los que se exponen los individuos en África, para luego examinar los avances del marco legal de la Unión Africana en la prevención de conflictos con énfasis en la seguridad de los individuo...

  11. La determinación del comienzo de la vida humana: cuestiones de método

    OpenAIRE

    Antonio Pardo Caballos

    2007-01-01

    Para el estudio ético de las intervenciones sobre el comienzo de la vida humana es decisivo conocer cuándo comienza ésta exactamente. Para conseguir este resultado, es necesario combinar conocimientos fi losófi cos sobre la vida y observaciones empíricas de los primeros momentos del desarrollo. A partir de ellos, se puederealizar un razonamiento que permite mostrar que la fecundación establece el momento de aparición de una nueva vida humana. Las refl exiones estrictamente científi cas, y la...

  12. Escuela de las Relaciones Humanas en la Administración: antecedentes = School of Human Relations in Administration: background

    OpenAIRE

    Rendón Giraldo, Lina María

    2011-01-01

    La Escuela de Relaciones Humanas en Administración surgió al final de la década de 1920 en Estados Unidos, formalizada a partir de los estudios Hawthorne de Elton Mayo. El presente texto tiene como objetivo identificar y documentar los antecedentes de la Escuela de Relaciones Humanas en Administración hasta finales de la década de 1920 que constituyen anticipaciones a los planteamientos de Elton Mayo. La búsqueda se centra en los aspectos humanistas en el trabajo en diferentes épocas históric...

  13. Hallazgo de impresiones de uñas humanas en un fragmento de cerámica aborigen de Cuba

    Directory of Open Access Journals (Sweden)

    Manuel F. Rivero de la Calle

    2008-11-01

    Full Text Available Se da a conocer un conjunto de impresiones de uñas humanas, las que aparecen en la cara externa del fondo de una cazuela aborigen recuperada en el sitio arqueológico agroalfarero Toma de Agua, municipio La Sierpe, provincia Sancti Spíritus. En la cara interna del ejemplar se descubre también dos pequeños trazos que se identifican así mismo como correspondientes a uñas humanas.

  14. Resultados de promoción en la asignatura Morfofisiología Humana III durante tres cursos

    OpenAIRE

    Inés María del Rio Ventura; Nixy Milagros Báez Hechavarría; Ileana Vila Rodríguez

    2014-01-01

    Durante el curso escolar 2007/2008 se comenzó a implementar el nuevo programa de formación de médicos. El mismo consistió en agrupar las disciplinas de las ciencias básicas biomédicas en una sola disciplina, la Morfofisiología Humana, la cual está dividida a su vez en seis asignaturas, que son impartidas en los tres primeros semestres de la Carrera de Medicina. La Morfofisiología Humana III es la asignatura que imparte los contenidos relacionados con el sistema nervioso. Se realizó una invest...

  15. Efeito da aplicação de hCG ou GnRH sobre a concentração sérica de progesterona e eficiência reprodutiva em porcas Effect of injection of hCG or GnRH on progesterone serum concentration and reproductive efficiency of sows

    Directory of Open Access Journals (Sweden)

    L.F.R. Carvalho

    2003-12-01

    Full Text Available Avaliou-se o efeito da aplicação de diferentes hormônios no quinto dia após a primeira inseminação sobre a concentração sérica de progesterona e sobre as características reprodutivas, em 103 porcas entre o terceirro e sexto parto. As matrizes foram divididas em: grupo-controle (n=35, não tratado, grupo GnRH (n=34, animais submetidos à aplicação intramuscular (IM de 50mcg de um análogo-GnRH no quinto dia após a primeira inseminação, e grupo hCG (n=34, animais submetidos à aplicação IM de 500UI de hCG no quinto dia após a primeira inseminação. A aplicação dos hormônios não influenciou as características reprodutivas taxa de parto, número total de nascidos, número de nascidos vivos e peso da leitegada (P>0,05. Cinco animais de cada grupo foram submetidos a coletas de sangue da veia cava nos dias 3, 5, 8, 12, 21 e 28 após a primeira inseminação para avaliação da concentração sérica de progesterona (ng/ml, utilizando a técnica de radioimunoensaio. Não houve diferença significativa quanto à concentração sérica de progesterona entre os grupos.Two different hormones were administered on the fifth day after the first insemination to evaluate their influence on serum progesterone concentrations and on reproductive efficiency, in multiparous sows between the third and the sixth parturition. The reproductive performance was evaluated in 103 sows distributed into three groups: 1-Control (n=35; 2-GnRH, 50m g of GnRH-analogue, administered IM on the fifth day after the first insemination (n=34; and 3-hCG, 500 IU of hCG administered IM in the fifth day after the first insemination (n=34. No effect (P>0.05 of hormone treatments on farrowing rate, litter size, live born and litter weight was observed. Five sows of each group were blood sampled on days 3, 5, 8, 12, 21, 28, after the first insemination, to evaluate serum progesterone concentrations (ng/ml. Serum progesterone concentrations were not affected (P>0.05 by

  16. A randomized controlled trial comparing the efficacy and safety of two HMG preparations gaining their LH bioactivity from different HCG sources

    DEFF Research Database (Denmark)

    Lockwood, Gillian; Cometti, Barbara; Bogstad, Jeanette

    2017-01-01

    In this prospective, controlled, randomized, multicentre, non-inferiority study, efficacy and safety of two HMG preparations (Menopur(®)- Ferring and Meriofert®- IBSA Institut Biochimique SA) for ovarian stimulation were compared (270 women undergoing IVF aged between 18 and 39 years; BMI 30 kg/m(2......) or less; less than three prior completed assisted reproduction technique cycles). A standard long down-regulation with gonadotrophin-releasing hormone agonist protocol, with HCG triggering was used; primary end-point was total number of oocytes retrieved; attention was paid toovarian hyperstimulation...... syndrome (OHSS). No statistically significant differences between the treatment groups were reported for most of the clinically significant end-points, including embryo quality, fertilization rate, implantation rate, ongoing pregnancy rate and live birth rate. Total number of oocytes retrieved was higher...

  17. Human endometrial milk fat globule-epidermal growth factor 8 (MFGE8) is up regulated by estradiol at the transcriptional level, and its secretion via microvesicles is stimulated by human chorionic gonadotropin (hCG)

    KAUST Repository

    Sarhan, Abbaa

    2013-10-17

    Objective: We have recently showed that MFGE8, a novel epithelial cell protein in the human endometrium, upregulated during the window of implantation. We hypothesized that MFGE8 may act as a key modulator of endometrial remodeling and trophoblast invasion. The aims of this study were (i) to investigate the in vitro regulation of human endometrial epithelial cells MFGE8 transcription, translation, and secretion by sex steroids and hCG; and (ii) to examine the possibility of MFGE8 secretion via microvesicles. Design: Experimental in vitro study using Ishikawa cells. Setting: University center. Interventions: Treatment with estradiol (E2), progesterone (P4), and human chorionic gonatropin (hCG). Main outcome measures: MFGE8 mRNA and protein expression, and identification of secreted microvesicles by mass spectrometry (MS) and immunoblotting. Results: E2, but not P4 or hCG, significantly upregulated MFGE8 mRNA expression. hCG significantly increased MFGE8 secretion. Microvesicels obtained after ultracentrifugation were visualized with atomic force microscopy ranging from ~100 to 200 nm. In addition to the expected 46 kD protein, the microvesicles contained a second form of secreted MFGE8 measuring ~30 kD which was confirmed by MS. Conclusions: We demonstrated (i) dual effects of E2 and hCG on the regulation of MFGE8, and (ii) MFGE8 protein secretion in association with microvesicles. MFGE8 has the potential to modulate endometrial function and implantation via exocrine and/ or paracrine-autocrine effects. To the best of our knowledge, this is the first demonstration of microvesicular secretion of any regulatory protein by endometrial epithelial cells, providing initial evidence suggestive of microvesicular participation in cellular trafficking information in the non-pregnant and pregnant endometrium.

  18. Ansiedade e impaciência: cânceres sociais na Educação e Relações Humanas

    Directory of Open Access Journals (Sweden)

    Antonio Mendes Silva Filho

    2016-02-01

    Full Text Available Os hábitos dizem muito da natureza humana e podem ajudar ou dificultar a formação humana. Aristóteles nos ensina a entender a natureza humana quando diz que “somos aquilo que fazemos repetidamente”. Hábitos consistem de padrões comportamentais realizados costumeiramente, frutos da frequente repetição de atos. Portanto, hábitos constituem traços que seres humanos podem desenvolver ao longo da vida. Os hábitos ajudam a compreender a natureza humana, pois eles os acompanham ao longo da vida como virtudes ou defeitos. Mas, a virtude torna-se em vício se mal aplicada. Este artigo explora e discute hábitos, cânceres sociais, que têm afetado a educação e relações humanas

  19. Simulación de la marcha humana mediante técnicas de dinámica multicuerpo : aplicación al diseño de sistemas para la asistencia de la marcha humana

    OpenAIRE

    Sánchez Salinas, Silvia

    2014-01-01

    En este trabajo se ha llevado a cabo una metodología basada en sistemas multicuerpo para realizar el análisis dinámico de la marcha humana. Escuela Técnica Superior de Ingeniería Industrial Universidad Politécnica de Cartagena

  20. Aflatoxinas e ocratoxina A em alimentos e riscos para a saúde humana

    Directory of Open Access Journals (Sweden)

    Eloisa Dutra Caldas

    2002-06-01

    Full Text Available OBJETIVOS: A presença de micotoxinas em alimentos tem sido correlacionada a várias patologias humanas, e as autoridades de saúde no mundo todo têm implementado ações para diminuir a ingestão desses compostos pela dieta. Realizou-se pesquisa para analisar os níveis de aflatoxinas e ocratoxina A de alimentos para consumo e avaliar o potencial de risco da exposição humana a essas micotoxinas. MÉTODOS: Foram analisadas 366 amostras de alimentos consumidos no Distrito Federal, no período de julho de 1998 a dezembro de 2001, como amendoim e derivados, castanhas, milho, produtos de trigo e/ou aveia, arroz e feijão. As amostras foram processadas, e as micotoxinas extraídas, detectadas e quantificadas por fluorescência após separação em cromatografia camada delgada. RESULTADOS: Foram detectadas aflatoxinas em 19,6% das amostras, em amendoim cru e derivados, milho de pipoca, milho em grão e castanha-do-pará (>2 mig/kg. Amendoim e derivados apresentaram maior incidência de contaminação por aflatoxinas (34,7% com amostras contendo até 1.280 mig/kg de AFB1+AFG1 e 1.706 mig/kg de aflatoxinas totais. Das amostras positivas, AFB1 estava presente em 98,5%, AFB2 em 93%, AFG1 em 66,7% e AFG2 em 65,4%. A ocratoxina A não foi detectada (<25 mig/kg em nenhuma amostra analisada. CONCLUSÃO: Os níveis de contaminação encontrados em amendoim e derivados ultrapassaram os níveis máximos permitidos pela legislação brasileira, podendo significar fator de risco para a população que os consome regularmente. A conscientização dos produtores de alimentos e as ações de vigilância sanitária permanentes são essenciais para diminuir a exposição humana a esses compostos e prevenir doenças crônicas advindas dessa exposição.

  1. Aflatoxinas e ocratoxina A em alimentos e riscos para a saúde humana

    Directory of Open Access Journals (Sweden)

    Caldas Eloisa Dutra

    2002-01-01

    Full Text Available OBJETIVOS: A presença de micotoxinas em alimentos tem sido correlacionada a várias patologias humanas, e as autoridades de saúde no mundo todo têm implementado ações para diminuir a ingestão desses compostos pela dieta. Realizou-se pesquisa para analisar os níveis de aflatoxinas e ocratoxina A de alimentos para consumo e avaliar o potencial de risco da exposição humana a essas micotoxinas. MÉTODOS: Foram analisadas 366 amostras de alimentos consumidos no Distrito Federal, no período de julho de 1998 a dezembro de 2001, como amendoim e derivados, castanhas, milho, produtos de trigo e/ou aveia, arroz e feijão. As amostras foram processadas, e as micotoxinas extraídas, detectadas e quantificadas por fluorescência após separação em cromatografia camada delgada. RESULTADOS: Foram detectadas aflatoxinas em 19,6% das amostras, em amendoim cru e derivados, milho de pipoca, milho em grão e castanha-do-pará (>2 mig/kg. Amendoim e derivados apresentaram maior incidência de contaminação por aflatoxinas (34,7% com amostras contendo até 1.280 mig/kg de AFB1+AFG1 e 1.706 mig/kg de aflatoxinas totais. Das amostras positivas, AFB1 estava presente em 98,5%, AFB2 em 93%, AFG1 em 66,7% e AFG2 em 65,4%. A ocratoxina A não foi detectada (<25 mig/kg em nenhuma amostra analisada. CONCLUSÃO: Os níveis de contaminação encontrados em amendoim e derivados ultrapassaram os níveis máximos permitidos pela legislação brasileira, podendo significar fator de risco para a população que os consome regularmente. A conscientização dos produtores de alimentos e as ações de vigilância sanitária permanentes são essenciais para diminuir a exposição humana a esses compostos e prevenir doenças crônicas advindas dessa exposição.

  2. A Vontade de Vida Schopenhaueriana como a Essência Humana: Um Golpe à Presunção Racional

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    Camila Koerich Espíndola

    2009-06-01

    Full Text Available O presente artigo tem o objetivo de mostrar que a Vontade de vida, apresentada por Arthur Schopenhauer como a essência íntima tanto dos seres humanos quanto da natureza em geral, pode ter o efeito de igualar a humanidade aos demais seres vivos, abalando a presunção humana fundamentada na capacidade racional.

  3. O modelo de tomasello sobre a evolução cognitivo-linguística humana

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    Sylvio Állan

    Full Text Available O presente trabalho buscou apresentar o modelo de Michael Tomasello sobre a evolução da cognição humana e uma teoria, derivada desse modelo, sobre a aquisição e o desenvolvimento de competências linguístico-simbólicas. Tomasello propõe que a aquisição e o desenvolvimento simbólico dependem de uma cognição cultural exclusivamente humana, mas derivada de adaptações biológicas características da cognição primata. Essas propostas constituem alternativas para as abordagens tradicionais do desenvolvimento cognitivo e linguístico-simbólico humano, uma vez que: (1 destacam aspectos biológicos e culturais como determinantes da cognição humana; (2 consideram as atividades humanas como essencialmente simbólicas; (3 fornecem uma nova concepção de linguagem.

  4. 77 FR 56674 - United States v. Humana Inc. and Arcadian Management Services, Inc.; Public Comment and Response...

    Science.gov (United States)

    2012-09-13

    ... Demands and conducted more than fifty-three interviews of health-insurance competitors, brokers, customers... (CMS), have more robust physician networks, and seek high patient satisfaction and quality in order to... by Humana and the DOJ's continued work to ensure that competition among insurers is sufficient to...

  5. PREVALENCIA DE HIDATIDOSIS HUMANA MEDIANTE TÉCNICAS DE IMAGEN EN YANAHUANCA, PASCO.

    OpenAIRE

    Chumbe G., Elizabeth; Laboratorio de Medicina Veterinaria Preventiva, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima; Lopera B., Luis; Laboratorio de Medicina Veterinaria Preventiva, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima; Barrón G., Eduardo; Laboratorio de Medicina Veterinaria Preventiva, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima; Ninaquispe B., Berenice; Laboratorio de Medicina Veterinaria Preventiva, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima; Gavidia Ch, César .; Laboratorio de Medicina Veterinaria Preventiva, Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima

    2011-01-01

    El objetivo del estudio fue determinar la prevalencia de hidatidosis humana en nueve comunidades rurales del distrito de Yanahuanca, Pasco, empleando como técnicas de diagnóstico la ecografía abdominal y la radiografía de tórax. Además, se evaluó la asociación entre las variables edad, género y comunidad de procedencia y la presencia de pobladores positivos a quistes hidatídicos. La ecografía se realizó a 949 personas (52% de la población mayor de 5 años) y el examen radiográfico a 829 (45.6%...

  6. Ecosystem approaches to human health Abordagens ecossistêmicas à saúde humana

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    N. Ole Nielsen

    2001-01-01

    Full Text Available The promotion of human health must be embedded in the wider pursuit of ecosystem health. Interventions will be impaired if ecosystem-linked determinants of health are not taken into account. In the extreme case, if ecosystems lose their capacity for renewal, society will lose life support services. Essential features of ecosystem health are the capacity to maintain integrity and to achieve reasonable and sustainable human goals. An ecosystem approach to research and management must be transdisciplinary and assure participation of stakeholders. These requisites provide a means for science to better deal with the complexity of ecosystems, and for policy-makers and managers to establish and achieve reasonable societal goals. The ecosystem approach can determine links between human health and activities or events which disturb ecosystem state and function. Examples are: landscape disturbance in agriculture, mining, forestry, urbanization, and natural disasters. An understanding of these links can provide guidance for management interventions and policy options that promote human health. An ecosystem approach to management must be adaptive because of irreducible uncertainty in ecosystem function.A promoção da saúde humana deve estar embutida na busca maior pela saúde do ecossistema. As intervenções estarão prejudicadas se os determinantes ecossistêmicos da saúde não forem levados em conta. Em caso extremo, se os ecossistemas perderem a capacidade de se renovarem, a sociedade ficará privada de serviços essenciais à sustentação da vida. As características essenciais da saúde ecossistêmica são a capacidade de manter a integridade e a de atingir metas humanas razoáveis e sustentáveis. Uma abordagem ecossistêmica para a pesquisa e gestão deve ser transdisciplinar e assegurar a participação dos diferentes atores. Tais características fornecem um meio à ciência para lidar melhor com a complexidade dos ecossistemas, bem como aos

  7. Misión y vocación universitaria y persona humana

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    Jesús GONZÁLEZ LÓPEZ

    2009-11-01

    Full Text Available RESUMEN: El artículo es una reflexión del autor sobre el sentido y fines que la Universidad debe buscar en Chile en la perspectiva de un nuevo siglo. La Universidad debe constituirse, en primer lugar, como comunidad humana e intelectual. Pero, en segundo lugar, la dimensión ética de la persona es una perspectiva de fondo que no puede abandonar ninguna tarea desarrollada en la Universidad.ABSTRACT: This article is a reflection about the meaning and goals of the University in Chile at the thresold of the next century. First of all, the University must be a human and intellectual community. But the ethical dimension of the person is also most important for the universitary task.

  8. Pode Realmente Haver uma Ciência Natural da Ação Humana?

    Directory of Open Access Journals (Sweden)

    Sérgio Oliveira

    2014-05-01

    Full Text Available Procura-se, neste texto, expor, de forma sucinta, a argumentação, com base na perspectiva de Clifford Geertz, segundo a qual a ação humana se torna um objeto falseado à medida que entendida pelas estratégias de investigação típicas das ciências naturais, as quais procuram fornecer alguma descrição universal da mesma. A contrapelo desta tendência, lembra-se aqui o vínculo da ação complexa com sentidos para sempre locais e a necessidade, em se observando tal ponto, de se imaginarem “descrições densas” que procurem reconstruir a riqueza e as particularidades desses mesmos sentidos, como se pertencessem a um texto literário.

  9. La espiritualidad y la solución de crisis humanas

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    Rosalvina Alvis Barranco

    2015-01-01

    Full Text Available El presente artículo es un ensayo que compara tres estrategias de si- coterapia para el tratamiento de los conflictos humanos, demostrándose que la evocación de la espiritualidad humana ofrece resultados compara- bles cuando se aplica la psicoterapia cognitiva y la logoterapia. Se reali- zó un ensayo clínic o y a doble ciegas entre los 1.500 pacientes atendidos en la oficina de Asesoría Espiritual de la Universidad Popular del Cesar entre los años 2011-2014. Una conceptualización del caso sólida y bien estructurada, incrementa las probabilidades de éxito terapéutico.

  10. Dientes y diversidad humana: avances de la antropología dental

    OpenAIRE

    Rodríguez Cuenca, José Vicente

    2003-01-01

    La antropología dental estudia la evolución de las enfermedades dentales, la variación morfológica y métrica de la dentición en las poblaciones humanas, su relación con los procesos adaptativos y con los cambios en la alimentación. / Contenido. Preliminares; Capítulo 1 - Los dientes de la historia; Capítulo 2 - Evolución del sistema dental; Capitulo 3 - Variación dental morfológica; Capítulo 4 - Variación en el tamaño de los dientes; Capítulo 5 - Edad y desarrollo dental; Capítulo 6 - Diente...

  11. Genética en humana en Estomatología

    OpenAIRE

    2014-01-01

    El creciente interés que están despertando las enfermedades genéticas dentro del contexto de la patología humana, se debe al espectacular avance que han experimentado las cada vez más complejas metodologías que con un número día a día mayor de científicos investigan los mecanismos de la herencia. Es así como novedosos estudios bioquímicos, cromosómicos y poblaciones, han permitido reconocer en muchas entidades de causalidad confusa hasta no hace mucho, una clara etiología genética. El crec...

  12. Toxicología de las dioxinas y su impacto en la salud humana

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    Anastasia Cruz Carrillo

    2010-06-01

    Full Text Available Las dioxinas son contaminantes de síntesis que se forman de manera espontánea en diversos procesos industriales. Son compuestos organoclorados muy estables en el medio ambiente, capaces de permanecer en los tejidos humanos y animales; y por ello hacen bioacumulación, lo que facilita la presentación de toxicidad crónica, dentro de la que se destaca la carcinogenicidad, la mutagenicidad y el efecto disruptor endocrino. Se hace referencia a las características físicoquímicas de estos compuestos, a su toxicodinamia y efectos adversos, para finalmente, relacionar la toxicidad de estos compuestos con la salud humana y con la responsabilidad de producir alimentos inocuos para el ser humano.

  13. Excelência Humana: a contribuição da personalidade

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    Seille Cristine Garcia-Santos

    2012-08-01

    Full Text Available Este estudo teve por objetivo analisar, sob o enfoque da Psicologia Positiva, as explicações dos pesquisadores da excelência humana sobre o que a promove e a mantém nos mais variados domínios de atuação. Constatou-se que fatores pessoais e contextuais são mencionados, destacando-se as habilidades cognitivas e a prática deliberada no desempenho superior, sendo também as variáveis de personalidade decisivas para o desenvolvimento e a manifestação da excelência. Neste estudo, como na literatura na área, destaca-se a importância da persistência, controle emocional e abertura à experiência.

  14. La enseñanza de la ética y la conducta humana

    OpenAIRE

    SARABIA ARCE, Silvana Virginia

    2013-01-01

    La ética (Gr.ethos comportamiento y hábitos del hombre) (1) es la ciencia que busca razones últimas y universales para adecuar la conducta humana al bien del universo. Deontología (Gr. deonta lo que debería de ser) (1) es la ciencia de los deberes profesionales.Por muchos años se creyó que la ética no podía ser enseñada, que era parte del individuo. Se postulaba que era más sencillo enseñar medicina a personas éticas que enseñar ética a estudiantes de medicina ¿será esto así? (2). Una buena p...

  15. La construcción de esquemas: un modelo explicativo de construcción humana

    OpenAIRE

    Aznar Minguet, Pilar

    2009-01-01

    Desde el alternativismo constructivista, se ha venido enfatizando el proceso activo del sujeto en la elaboración e interpretación de información, lo cual ha llevado a establecer como postulado básico el hecho de que la construcción de la realidad es un proceso activo y personal. Esta particular explicación de la configuración humana a través de la acción surge como reacción a la explicación conductista por la grave carencia que suponía, desde ésta, el hacer depender la configuración conductua...

  16. Aproveitamento teórico-prático da disciplina anatomia humana do curso de fisioterapia

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    Rodrigo Moreira Arruda

    Full Text Available A Anatomia Humana estuda as estruturas do corpo humano e as relações entre elas. Assim, seu ensino a estudantes da área da saúde, incluindo alunos de Fisioterapia, é de extrema importância. É necessário um bom aproveitamento nesta disciplina para se tornar um bom profissional, porém as estratégias de ensino-aprendizagem nesta disciplina têm sido bastante discutidas. Com base nesta premissa, este estudo teve por objetivos avaliar o aproveitamento teórico-prático dos discentes do curso de Fisioterapia na disciplina Anatomia Humana, bem como descrever as facilidades e dificuldades enfrentadas e suas implicações durante o curso. Para tanto, foi elaborado um questionário específico e utilizada também a avaliação dos professores realizada pelo Colegiado de Fisioterapia. O tratamento estatístico foi composto por análise descritiva e correlação de Pearson, sendo os dados analisados pelos programas Microsoft Excel® 2007 e Graphpad Prism®. Não se observou correlação entre desempenho do aluno e grau de satisfação diante de diferentes parâmetros analisados neste trabalho. O estudo revelou que os alunos apresentam aproveitamento satisfatório, mas há grandes insatisfações quanto à forma como a disciplina é conduzida.

  17. La Placenta Humana Nuevo Sustrato Proteico Empleado para la Obtención de Bases Nutritivas.

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    Diana Rosa Viera Oramas

    2005-01-01

    Full Text Available El hidrolizado de placenta humana es una nueva base nutritiva con un elevado contenido de nutrientes y constituyen un paso importante en el desarrollo de una metodología para su obtención a partir de residuos de placenta. Además de ser un nuevo producto en la gama de BIOCEN y brindar la posibilidad de utilizar en sustitución de bases nutritivas importadas. Con el objetivo de desarrollar y evaluar la funcionalidad de dicha base se realizó un diseño experimental completamente aleatorio, se estudió la influencia de parámetros fundamentales en el proceso de obtención tales como: cantidad de enzima, tiempo de hidrólisis y relación sustrato agua. Definiendo que 0,4 g de papaína por Kg de sustrato, durante 4 hora de hidrólisis y en una relación 1: 5 sustrato agua, además de un tratamiento térmico durante 30 min fueron los elementos críticos prefijados en la tecnología de obtención del hidrolizado. Se obtuvo un producto con elevada calidad cuyos valores óptimos de los índices fisicoquímicos fueron: nitrógeno amínico 2,38 % nitrógeno total 13,62 % y un rendimiento 14,56 % . Al realizar la evaluación microbiológica de la peptona a nivel piloto se obtuvieron resultados satisfactorios y correspondiente a los descrito en la documentación. Esta nueva base nutritiva es una prueba de la posibilidad de utilizar los residuos de placenta humana en calidad de sustrato proteico con una calidad adecuada comparable con los productos de similar propósito existentes en el mercado internacional.

  18. Enfermedades infecciosas emergentes: interacción entre el mundo microbiano y las sociedades humanas

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    Fernando García

    2008-09-01

    Full Text Available En este artículo se analizan dos facetas importantes de las enfermedades infecciosas emergentes. Por un lado, las características de los microorganismos que las causan, por otro, las características del ser humano que promueven o contribuyen al surgimiento de las enfermedades infecciosas. Desde el punto de vista microbiano, se pueden identificar tres aspectos fundamentales. Primero, los patógenos emergentes son predominantemente virales, seguidos por los bacterianos. Numéricamente los virus ARN dominan, constituyendo el 37% de todos los patógenos emergentes. Los virus ARN predominan entre los virus patógenos emergentes que aparentemente entraron en las poblaciones humanas en las últimas décadas, como VIH y el coronavirus asociado al SARS. Segundo, los patógenos emergentes no se asocian a un único tipo de hospedero, sino que usualmente tienen amplio rango de hospederos que incluye varios órdenes de especies de mamíferos y no mamíferos. En efecto, la mayoría de las infecciones emergentes son de origen zoonótico. Tercero, los patógenos emergentes tienen un cierto grado de flexibilidad biológica que les permite aprovecharse de nuevas oportunidades epidemiológicas para ingresar a las poblaciones humanas. Las enfermedades infecciosas no son un problema reciente sino que han estado "emergiendo" a lo largo de la historia de la humanidad y es posible identificar, al menos, cuatro transiciones históricas. La última de esas transiciones es la globalización actual. Muchos factores antropogénicos inciden en el surgimiento de las enfermedades infecciosas emergentes, incluyendo eventos sociales, comportamiento humano, cambios ambientales, políticas en salud pública, procedimientos médicos y otros.

  19. NEUROÉTICA Y VULNERABILIDAD HUMANA EN PERSPECTIVA FILOSÓFICA

    Directory of Open Access Journals (Sweden)

    ALFREDO MARCOS

    2015-01-01

    Full Text Available El artículo trata de valorar las posibilidades y límites de la neuroética. Defiende que las neurociencias y la ética deben colaborar entre sí desde el mutuo respeto y la preservación de las respectivas identidades, científica en un caso y filosófica en el otro (neuroética en modo-co . El texto formula también una crítica a todo intento de sustitución de la ética filosófica por las neurociencias (neuroética en modo-su. En consecuencia, se exploran los fundamentos ontológicos y antropológicos más apropiados para desarrollar la neuroética, entendida esta como territorio de colaboración entre ética y neurociencias. Dichos fundamentos remiten a la idea aristotélica de sustancia hilemórfica. Sobre tales fundamentos se puede desarrollar una neuroética colaborativa que incluye dos vertientes: por un lado tenemos una ética de la neurociencia y, por otro, una neurociencia de la ética. La primera muestra cómo investigar y aplicar la neurociencia preservando siempre la dignidad humana. La segunda nos enseña cuáles son las bases neurobiológicas posibilitadoras –pero no determinantes– de la agencia moral. Al estudiar las mismas se hace evidente nuestra vulnerabilidad como agentes morales. Esta vulnerabilidad, que arraiga en la propia naturaleza humana, ha de ser, como se argumenta en el último tramo del texto, reconocida y a la vez mitigada.

  20. Direito e reprodução humana assistida nas uniões homoafetivas

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    José Márcio Carvalho da Silva

    2014-10-01

    Full Text Available A reprodução humana assistida em uniões homoafetivas é uma temática envolta em controvérsias na sociedade contemporânea, motico pelo qual o Poder Judiciário frequentemente é acionado no intuito de dirimir os conflitos existentes. Apesar da união de pessoas do mesmo sexo ser uma configuração familiar cada vez mais frequente no Brasil, o ordenamento brasileiro ainda é frágil em relação ao deslinde da questão. A inexistência de mecanismos legais específicos no país coloca o assunto em uma posição vulnerável a questionamentos éticos, morais, médicos, religiosos e sociais. Considerando este cenário de inegável transformação da estrutura familiar, o presente trabalho teve como objetivo principal analisar as repercussões jurídicas da reprodução humana assistida nas uniões homoafetivas. As considerações trazidas por este trabalho sinalizam que mesmo diante de alguns avanços, lacunas importantes necessitam ser preenchidas no âmbito do Direito. Algumas sentenças já foram favoráveis ao reconhecimento da paternidade e maternidade de casais homoafetivos cujos filhos foram gerados por meio de métodos de reprodução assistida, entretanto, as respostas aos dilemas que envolvem esse tipo de cinstituição familiar contemporânea ainda carecem de mecanismos legais mais concretos.

  1. Habermas, identidad moderna y mejora humana. ¿El camino a seguir?

    Directory of Open Access Journals (Sweden)

    Francisco Javier Lopez Frías

    2014-10-01

    Full Text Available La finalidad de este artículo es triple. Primero, las secciones 1 y 2 expondrán la estructura del argumento de Jürgen Habermas respecto a las tecnologías de mejora humana. Para ello, éste será descompuesto en tres partes, que son sus pilares básicos: a los sujetos diseñados no pueden auto-concebirse a sí mismos como autores únicos de sus vidas; b la distinción kantiana entre objetos y personas se desvanece como consecuencia del modo en que los sujetos modificados experiencian su cuerpo; c la relación entre los padres y su descendencia se vuelve asimétrica, de modo que es contraria a las normas de la acción comunicativa. Segundo, en la sección 3, que es concebida como un diálogo entre Habermas y sus críticos, se presentarán algunas objeciones teóricas a su argumento. Tercero, la sección 4 analizará la validez de los argumentos habermasianos y afirmará firmemente que la posición de Habermas arroja luz sobre el modo correcto de analizar las tecnologías de mejora humana desde un punto de vista moral. A saber, en función de la influencia que tienen sobre el modo en que los sujetos se auto-conciben como seres autónomos y responsables.

  2. Uveítis sifilítica asociada al virus de inmunodeficiencia humana

    Directory of Open Access Journals (Sweden)

    Isabel Ambou Frutos

    Full Text Available La sífilis es una infección crónica y multisistémica, producida por la espiroqueta Treponema pallidum. Las manifestaciones oculares de la sífilis son varias y pueden afectar todas las estructuras oculares. La uveítis es el tipo de afectación ocular más frecuente. Puede presentarse en la fase secundaria, latente o terciaria y cursa de forma bilateral en el 50 % de los casos. También puede verse asociada al virus de inmunodeficiencia humana. Desde la introducción de la terapia antirretroviral de gran actividad, la mortalidad asociada al SIDA disminuyó y la incidencia de sífilis y otras enfermedades de trasmisión sexual aumentó como consecuencia de la expansión de la población homosexual. Teniendo en cuenta la gran variedad de formas de presentación, se le conoce como la gran simuladora y forma parte del diagnóstico diferencial de cualquier uveítis. Presentamos el caso de un paciente masculino de 64 años de edad que acude al Cuerpo de Guardia, donde refiere visión borrosa del ojo derecho de aproximadamente 45 días de evolución, asociado a enrojecimiento ocular, dolor y molestias a la luz, a quien posteriormente se le diagnóstico una uveítis sifilítica asociada al virus de inmunodeficincia humana.

  3. Diagnóstico de la toxocarosis humana Diagnosis of human toxocarosis

    Directory of Open Access Journals (Sweden)

    William H. Roldán

    2010-12-01

    Full Text Available La toxocarosis humana es una importante zoonosis parasitaria causada por formas larvarias de especies del género Toxocara, un parásito nematodo de los perros y los gatos. La migración de la larva por los diferentes tejidos blandos en el ser humano genera una serie de entidades clínicas en el paciente, tales como el síndrome de larva migrans visceral, la toxocarosis ocular y la neurotoxocarosis. El diagnóstico definitivo es mediante la histopatología en biopsias, pero resulta ser casi imposible de realizar y actualmente su diagnóstico se establece mediante el análisis de la sintomatología clínica, los antecedentes epidemiológicos del paciente y el uso de pruebas hematológicas e inmunológicas de laboratorio que son las que finalmente ayudan a confirmar la sospecha clínica de la enfermedad. El propósito del presente artículo es actualizar los conocimientos que se tienen sobre el uso de las diferentes herramientas para establecer el diagnóstico y el monitoreo de la toxocarosis humana.Human toxocarosis is an important parasitic zoonosis caused by larval stages of Toxocara species, the roundworms from dogs and cats. Larval migration through different soft tissues in the human generates several clinical entities in the patient, such as visceral larva migrans, ocular toxocarosis, and neurotoxocarosis. Definitive diagnosis by histopathological methods is very difficult or almost impossible and, nowadays, the diagnosis is usually made by clinical signs/symptoms, epidemiological background of the patient and the use of hematological and immunological tests which finally help to confirm the clinical suspicion of the illness. The purpose of this paper was to update the available knowledge on the use of different tools for both the diagnosis and following up of human toxocarosis.

  4. La díada en el desarrollo de la condición humana

    Directory of Open Access Journals (Sweden)

    Carmen Rosalía Solla

    2011-05-01

    Full Text Available Este artículo tiene como propósito realizar una disertación sobre la díada como estrategia socializadora que coadyuva al desarrollo de la condición humana, entendiendo ésta como la fuerza viva de interrelacionarse con su semejante, respetarlo, amarlo y ser empático son ese otro que está ahí para ser el complemento de uno. Esta investigación se desarrolla como un estudio documental, de tipo expositivo, ya que en éste se presentan los estudios de Valles (2004, Hernández y Cortés (2009, Solla (2003/2010 y, Rodríguez (2009 y se hace referencia a las teorías de Gadamer (1997, Heidegger (2003 y Bronfenbrenner (1987 como soportes al estudio de las relaciones complementarias, específicamente de la díada. Los trabajos antes mencionados se exponen en forma dialógica para que así uno sea complemento del otro. El artículo está compuesto por varias partes que guían al lector a entender al individuo desde su unicidad hasta la necesidad de complementarse con el otro quien le ayuda a ratificar su condición humana. Finalmente, se concluye que el ser humano, desde la relación diádica, abre su ser para desplegarse en el otro; promueve la interrelación, la comunicación, la cohesión, la afectividad, la reciprocidad, la solidaridad, el respeto y la dialógica; trabaja con su semejante y posibilita la formación de comunidades cohesionadas.

  5. Empowerment Zones and Enterprise Districts, File name = ENTERZONES County Enterprise Zone Call HCG Department of Economic Development for details. http://www.harfordcountymd.gov/gis/Index.cfm, Published in 2009, 1:1200 (1in=100ft) scale, Harford County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Empowerment Zones and Enterprise Districts dataset current as of 2009. File name = ENTERZONES County Enterprise Zone Call HCG Department of Economic Development for...

  6. Influence of FSH and hCG on the resumption of meiosis of bovine oocytes surrounded by cumulus cells connected to membrana granulosa.

    Science.gov (United States)

    van Tol, H T; van Eijk, M J; Mummery, C L; van den Hurk, R; Bevers, M M

    1996-10-01

    Cumulus oocyte complexes (COCs) and cumulus oocyte complexes connected to a piece of the membrane granulosa (COCGs) were isolated from bovine antral follicles with a diameter of 2 to 8 mm. After culture of COCGs without gonadotrophic hormones for 22 hr approximately 50% of the oocytes were still in the germinal vesicle (GV) stage. Histology of the COCGs showed that the pieces of the membrana granulosa were free of thecal cells and parts of the basal membrane. This indicates that the membrana granulosa solely inhibits the progression of meiosis. To investigate the effect of gonadotropins on the resumption of meiosis of oocytes from small and medium sized antral follicles, COCs and COCGs were cultured with or without rec-hFSH or hCG. Addition of 0.05 IU rec-hFSH to the culture medium of COCGs resulted in germinal vesicle breakdown in 97.8% of the oocytes compared to 46% in the control group, and an increase of the diameter of the COCs (479 microns vs. 240 microns in the control group). Addition of 0.05 IU hCG to the culture medium had no effect on nuclear maturation (47.2% GV vs. 48.5% GV in the control group) nor on cumulus expansion (246 microns vs. 240 microns in the control group). RT-PCR on cDNA of the follicular wall, cumulus cells, granulosa cells, COCs, and oocytes revealed that mRNA for FSH receptor was present in all cell types except oocytes. mRNA of the LH receptor was detected exclusively in thecal cells. Nucleotide sequence analysis and alignment of the cloned PCR products showed the presence of two isoforms of the FSH receptor mRNA and two isoforms of the LH receptor mRNA. It is concluded that, in vitro, resumption of meiosis of oocytes, originating from small and medium sized antral follicles and meiotically arrested by the membrana granulosa, is triggered by FSH and not by LH. This is supported by the fact that receptors for FSH, but not for LH, are transcribed in the cumulus and granulosa cells of these follicles.

  7. CONCEPTOS SOBRE GENÉTICA HUMANA PARA LA COMPRENSIÓN E INTERPRETACIÓN DE LAS MUTACIONES EN CÁNCER Y OTRAS PATOLOGÍAS HEREDITARIAS

    OpenAIRE

    Dra. Pilar Carvallo

    2017-01-01

    El avance del conocimiento en la genética humana en los últimos 20 años ha sido vertiginoso y el impacto que ha tenido en la salud humana es muy relevante. Por esta razón la revisión y el conocimiento de conceptos genéticos, desde la herencia Mendeliana aplicada a la genética humana hasta las enfermedades complejas, como el cáncer y su modo de herencia, resulta imprescindible para profesionales del área de la salud. El mejor conocimiento de los genes involucrados en el inicio y la progresión ...

  8. HCG与外用睾酮霜治疗小阴茎的临床疗效观察%HCG and transdermal testosterone therapy for the patients with micropenis

    Institute of Scientific and Technical Information of China (English)

    邓常开; 李旭良

    2010-01-01

    目的 探寻临床治疗小阴茎的有效治疗办法及其选择用药的依据.方法 按照小阴茎诊断标准选择病例,分为HCG组(肌注HCG,每次1000IU,每周2次,连用6周)和T组(每日外用睾酮霜2次),并于治疗前后测定阴茎长度、睾丸大小及性激素水平等以观察其疗效及影响.结果 阴茎长度测量:用药前两组阴茎长度比较无显著差异(P>0.05),而用药后两组均有显著增长(P0.05).睾丸体积测量:用药前两组睾丸体积比较无显著差异(P>0.05),但HCG组用药后有显著增长(P0.05).激素水平测定:除HCG组用药前后睾酮水平比较有显著性差异(P0.05).结论 肌注HCG和外用睾酮霜治疗儿童小阴茎均可使阴茎明显的增长,且对性激素水平无明显干扰,并与患儿年龄大小无关.但外用睾酮霜更为方便实用,在为使睾丸得到同步增长时也可首选HCG治疗.西药治疗无效时应想到雄激素抵抗综合症可能.%Objective To investigate the efficacy of HCG and transdermal testosterone therapy for the patients with micropenis.Methods Pediatric patients, who were diagnosed with micropenis,were divided into HCG and testosterone(T) group according to the treatments they received.In group HCG, 1000IU HCG was administered to patients by intramuscular injection twice a week for six weeks.In group T, testosterone cream was applied transdermally twice a day for 2 months.Penile length, testicular size, and sex hormone levels were measured during follow-up.Results No significant differences of penile length and testicular volume was noted between these 2 groups before medication initiation (P>0.05).After treatment, penile length increased in both groups (P0.05).After treatment, testicular volume markedly increased in HCG group (P0.05).Conclusions HCG and trandermal testosterone therapy can promote the growth of micropenis in different age without interfering sex hormone levels.Transdermal testosterone therapy is convenient and practical.HCG

  9. Mulheres doadoras de leite humano Mujeres donantes de leche humana Reasons women donate breast milk

    Directory of Open Access Journals (Sweden)

    Marli Teresinha Gimeniz Galvão

    2006-06-01

    Full Text Available OBJETIVO: verificar algumas variáveis do perfil sócio-demográfico de doadoras de leite humano no Banco de Leite e identificar as razões que as fazem doar seu leite. MÉTODOS: estudo exploratório de caráter descritivo, com abordagem qualitativa, realizado em maio de 2003 com 11 doadoras de leite humano em maternidade pública de Fortaleza-CE. Para coleta de dados utilizou-se formulário semi-estruturado. RESULTADOS: a maioria apresentava idade entre 16 e 20 anos, eram casadas, possuíam instrução do ensino fundamental até o universitário. O motivo que levou as nutrizes a doar seu leite era o ingurgitamento mamário e eram encaminhadas por profissionais de saúde. A maioria desconhecia os benefícios proporcionados pelo aleitamento materno para a mãe e filho, bem como a importância do Banco de Leite. CONSIDERAÇÕES FINAIS: sugere-se que as mulheres em geral devem receber informações a respeito dos benefícios e importância do aleitamento natural, incluindo informações sobre doação do leite humano, mediante os bancos de leite.OBJETIVO: se tuvo como objetivos verificar algunas variables del perfil socio-demográfico de donantes de leche humana en el Banco de Leche e identificar las razones que las llevan a donar su leche. MÉTODOS: estudio exploratorio de carácter descriptivo, con abordaje cualitativo, realizado en mayo del 2003 con 11 donantes de leche humana en una maternidad pública de Fortaleza-CE. Para la recolección de datos se utilizó un formulario semi-estructurado. RESULTADOS: la mayoría tenía edades comprendidas entre los 16 y 20 años, casadas, poseían instrucción de enseñanza fundamental. El motivo que llevó a las nutrices a donar su leche fue la turgencia mamaria siendo encaminadas por profesionales de salud. La mayoría desconocía los beneficios proporcionados por la lactancia materna tanto para la madre como para el hijo, así como la importancia del Banco de Leche. CONSIDERACIONES FINALES: se sugiere

  10. Marketing Ético como Fundamento del Bien Común en Organizaciones Humanas

    Directory of Open Access Journals (Sweden)

    Alejandro Fernández Baptista

    2014-01-01

    Full Text Available Los hombres poseen necesidades que deben ser satisfechas con el objeto de lograr una vida cónsona con los principios básicos de dignificación de la persona humana, alimento, vestido, medicamentos, comunicación, entretenimiento, transporte, entre otras, son algunas de las necesidades básicas que los seres humanos día tras día se esfuerzan por cubrir mediante el trabajo digno, utilizando para ello las potencialidades propias de cada quien. Las organizaciones modernas por medio del marketing como proceso administrativo, pretende lograr la satisfacción de tales necesidades por medio de la identificación oportuna de dichos requerimientos, elaborando productos y servicios que los satisfagan al crear una propuesta de valor superior a tales expectativas. Sin embargo, tal propuesta debería estar inmersa dentro de parámetros éticos y morales, las cuales garanticen la correcta utilización de cada uno de los elementos de la mezcla de mercadotecnia, producto, precio, promoción y la distribución. De esta manera los gerentes de marketing al momento de tomar decisiones éticas sobre estos tópicos, permitirían en desarrollo de organizaciones humanas promotoras del bien común dentro del contexto donde se desenvuelvanPalabras Clave: Marketing ético; Bien Común; Organizaciones Humanas. Marketing Ethical as the Foundation of the Common Wealth on Human OrganizationsAbstractThe people have needs that must be met for a life in keeping with the basic principles of dignification of the human person, food, clothing, medicines, communication, entertainment, transportation, among others, are some of the basic needs of human beings every day strive to cover using decent, using work of their own potential each person. Modern organizations marketing as administrative process aims at achieving the satisfaction of those needs in the timely identification of those requirements, developing products and services satisfying them to create a proposal for a value

  11. MicroRNA array and microarray evaluation of endometrial receptivity in patients with high serum progesterone levels on the day of hCG administration

    Directory of Open Access Journals (Sweden)

    Liu Ping

    2011-03-01

    Full Text Available Abstract Background To determine the effect of higher progesterone (P level on endometrial receptivity. Methods This was a prospective analysis conducted in the Reproductive Medical Center of Peking University Third Hospital. All patients received IVF treatment and canceled embryo transfer in the same cycle and were divided into group 1 (normal P; 7 patients and group 2 (elevated P; 12 patients. Endometrial biopsies were performed 6 days after oocyte retrieval. The global miRNA and mRNA gene expressions in endometrial biopsies were investigated with a V4.0 miRNA probe and 22 K Human Genome Array. Fold ratios were derived to compare gene regulation between the groups. Spp1 and Ang gene expression was selected to verify the array results by RT-PCR and the protein expression of osteopontin and VEGF was determined using an immunohistochemical method. Results There were 4 miRNA (all down-regulated and 22 mRNA (13 up-regulated and 9 down-regulated exhibiting differential expression between the groups on the microRNA and microarray chips. miRNA-451, Spp1, and Ang expression in RT-PCR verified the array results. Osteopontin and VEGF were also shown to have positive expression in the endometrium. Conclusions Data from microRNA and microarray analysis suggests dissimilar endometrial receptivity in patients with high P levels on the day of hCG, and elevated osteopontin and decreased VEGF had poor pregnancy rates.

  12. Daily low-dose hCG stimulation during the luteal phase combined with GnRHa triggered IVF cycles without exogenous progesterone

    DEFF Research Database (Denmark)

    Andersen, Claus Yding; Elbaek, Helle Olesen; Alsbjerg, Birgit

    2015-01-01

    STUDY QUESTION: Can the luteal phase support be improved in terms of efficacy, hormonal profiles and convenience as compared with today's standard care? SUMMARY ANSWER: Daily low-dose rhCG supplementation in GnRHa triggered IVF cycles can replace the traditional used luteal phase support with exo......STUDY QUESTION: Can the luteal phase support be improved in terms of efficacy, hormonal profiles and convenience as compared with today's standard care? SUMMARY ANSWER: Daily low-dose rhCG supplementation in GnRHa triggered IVF cycles can replace the traditional used luteal phase support...... on either stimulation day 2 or day 6. Blood samples were obtained on the day of ovulation induction, on the day of oocyte pickup (OPU) and day OPU + 7. MAIN RESULTS AND THE ROLE OF CHANCE: The mean serum levels of hCG did not exceeded the normal physiological range of LH activity in any samples. Mid...... were seen between groups. LIMITATIONS, REASONS FOR CAUTION: The number of patients included is limited and conclusions need to be verified in a larger RCT. WIDER IMPLICATIONS OF THE FINDINGS: Endogenous production of progesterone may become more attractive as the luteal phase support with levels of LH...

  13. Deep Chandra observations of HCG 16. II. The development of the intra-group medium in a spiral-rich group

    Energy Technology Data Exchange (ETDEWEB)

    O' Sullivan, E.; Vrtilek, J. M.; David, L. P.; Zezas, A.; Nulsen, P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Giacintucci, S. [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Ponman, T. J.; Raychaudhury, S. [School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT (United Kingdom); Mamon, G. A. [Institut d' Astrophysique de Paris (UMR 7095 CNRS and UMPC), 98 bis Bd Arago, F-75014 Paris (France)

    2014-10-01

    We use a combination of deep Chandra X-ray observations and radio continuum imaging to investigate the origin and current state of the intra-group medium (IGM) in the spiral-rich compact group HCG 16. We confirm the presence of a faint (L {sub X,} {sub bolo} = 1.87{sub −0.66}{sup +1.03}×10{sup 41} erg s{sup –1}), low-temperature (0.30{sub −0.05}{sup +0.07} keV) IGM extending throughout the ACIS-S3 field of view, with a ridge linking the four original group members and extending to the southeast, as suggested by previous ROSAT and XMM-Newton observations. This ridge contains 6.6{sub −3.3}{sup +3.9}× 10{sup 9} M {sub ☉} of hot gas and is at least partly coincident with a large-scale H I tidal filament, indicating that the IGM in the inner part of the group is highly multi-phase. We present evidence that the group is not yet virialized, and show that gas has probably been transported from the starburst winds of NGC 838 and NGC 839 into the surrounding IGM. Considering the possible origin of the IGM, we argue that material ejected by galactic winds may have played a significant role, contributing 20%-40% of the observed hot gas in the system.

  14. Deep Chandra Observations of HCG 16. II. The Development of the Intra-group Medium in a Spiral-rich Group

    Science.gov (United States)

    O'Sullivan, E.; Vrtilek, J. M.; David, L. P.; Giacintucci, S.; Zezas, A.; Ponman, T. J.; Mamon, G. A.; Nulsen, P.; Raychaudhury, S.

    2014-10-01

    We use a combination of deep Chandra X-ray observations and radio continuum imaging to investigate the origin and current state of the intra-group medium (IGM) in the spiral-rich compact group HCG 16. We confirm the presence of a faint (L X, bolo = 1.87+1.03-0.66×1041 erg s-1), low-temperature (0.30+0.07-0.05 keV) IGM extending throughout the ACIS-S3 field of view, with a ridge linking the four original group members and extending to the southeast, as suggested by previous ROSAT and XMM-Newton observations. This ridge contains 6.6+3.9-3.3× 109 M ⊙ of hot gas and is at least partly coincident with a large-scale {H} {I} tidal filament, indicating that the IGM in the inner part of the group is highly multi-phase. We present evidence that the group is not yet virialized, and show that gas has probably been transported from the starburst winds of NGC 838 and NGC 839 into the surrounding IGM. Considering the possible origin of the IGM, we argue that material ejected by galactic winds may have played a significant role, contributing 20%-40% of the observed hot gas in the system.

  15. Cultura e formação humana no pensamento de Antonio Gramsci

    Directory of Open Access Journals (Sweden)

    Vieira Carlos Eduardo

    1999-01-01

    Full Text Available Tomando por base a hipótese de que no âmbito do pensamento gramsciano existe uma indissociável vinculação entre conhecimento histórico, práxis política, luta cultural e formação humana, o artigo busca explicitar a sua reflexão sobre a formação do homem em sociedade como parte indissociável da sua teoria política. No sentido de evidenciar a pertinência dessa hipótese de leitura da obra de Gramsci, procura expor e interpretar as suas idéias à luz de um procedimento metodológico historicista que, supõe-se, possibilita situar os problemas teóricos, as idéias produzidas no passado, no âmbito dos seus contextos específicos de produção. As conclusões chamam a atenção para uma questão potencialmente relevante no âmbito da perspectiva gramsciana, ou seja, a possibilidade de, a partir de Gramsci, pensarmos uma teoria da formação humana que evite a redução da compreensão do processo formativo ao desenvolvimento intelectual do homem concebido isoladamente, da mesma forma que evite a pendular inversão, que entende a formação da personalidade de forma demasiadamente determinista, do homem como produto passivo do meio social. Gramsci pensa a questão da formação do indivíduo como uma função estratégica da política de implementação do projeto de uma classe, na perspectiva de se fazer hegemônica, como tarefa de uma vanguarda sobre a militância, como responsabilidade dos mais velhos perante os mais jovens, na perspectiva de criar formas mais avançadas de civilidade.

  16. Citotoxicidad y genotoxicidad en células humanas expuestas in vitro a glifosato.

    Directory of Open Access Journals (Sweden)

    Claudia Milena Monroy

    2005-09-01

    Full Text Available Introducción. El glifosato es un herbicida de amplio espectro, no selectivo, utilizado para eliminar malezas indeseables en ambientes agrícolas y forestales. La acción herbicida corresponde a la inhibición de la biosíntesis de aminoácidos aromáticos en las plantas. Al no ser este mecanismo compartido por los seres humanos es considerado como de bajo riesgo para la salud de los mismos. Sin embargo, investigaciones recientes indican que puede alterar otros procesos celulares en animales lo que puede presentar un factor de riesgo a nivel ambiental y de salud en las zonas donde se emplea este herbicida. Objetivo. El objetivo del presente estudio fue evaluar la citotoxicidad y la genotoxicidad del glifosato en células humanas normales (GM38 y en células humanas de fibrosarcoma (HT1080. Materiales y métodos. La citotoxicidad aguda y crónica se determinó al exponer las células en cultivo a diferentes concentraciones de glifosato, y se analizó la viabilidad celular con cristal violeta y colorante de exclusión azul de tripano, respectivamente. La genotoxicidad se determinó por medio del ensayo del cometa y los datos se analizaron usando la prueba de Dunnet. Resultados. En la citotoxicidad crónica las células GM38 y las HT1080 presentaron un efecto dependiente de la dosis después del tratamiento con glifosato en concentraciones de 5,2 a 8,5 mM y 0,9 a 3,0 mM, respectivamente. En la citotoxicidad aguda, las células GM38 y las HT1080 expuestas a un rango de concentraciones de 4,0 a 7,0 mM, 4,5 a 5,75 mM y 4,0 a 7,0 mM, respectivamente, presentaron una viabilidad mayor al 80%. Se evidenció daño en el ADN después del tratamiento con glifosato en concentraciones de 4,0 a 6,5 mM para las células GM38 y de 4,75 a 5,75 mM para las células HT1080. Conclusiones. Se sugiere que el mecanismo de acción del glifosato no se limita únicamente a las plantas sino que puede alterar la estructura del ADN en otros tipos de células como son las de

  17. Anticorpo protetor anti influenza humana detectado em cavalos, como virose zoonótica

    Directory of Open Access Journals (Sweden)

    Dalva Assunção Portari Mancini

    2004-11-01

    Full Text Available O objetivo deste estudo foi investigar em cavalos, a incidência do vírus influenza e seu ciclo de transmissão interespécies. Portanto, levantamento sorológico foi realizado em soro de cavalos, confrontados com ambas cepas, as específicas (eqüino e não específicas (humana deste vírus. Sangrias de cavalos realizadas nos anos de 1999 e de 2000, forneceram soros que, após tratamento com Caolim (20% e hemácias de galo(50% para remoção dos anticorpos inespecíficos, foram titulados contra ambas referidas cepas, através do teste de Inibição da Hemaglutinação (recomendado pela OMS. Os resultados, demonstraram que as respostas sorológicas dos cavalos apresentaram reação cruzada entre as cepas específicas e as não específicas. As porcentagens de títulos IH obtidos foram de 62,75% e de 60,65% para as cepas específicas A/Eq1 (H7N7 e A/Eq2 (H3N8, respectivamente. E às cepas não específicas essas porcentagens foram de: 79,05% para A (H1N1, de 94,45% para A (H3N2 e de 77,75% ao tipo B. O mais relevante nestes dados comparativos com vírus influenza, foi a alta porcentagem de resposta protetora à cepa não específica comparada àquela específica, detectada nos soros eqüinos. Considerando o fato de que o tipo B, deste vírus, ser restrito à espécie humana, portanto a resposta de proteção nos cavalos sugere uma direta transmissão interspécies, como em viroses zoonóticas. Os autores relatam pela primeira vez este tipo de evento no Brasil.

  18. La ciudadanía como condición humana

    Directory of Open Access Journals (Sweden)

    Jesús Andrés Vélez Vélez

    2017-01-01

    Full Text Available Este artículo después de hacer un rastreo sobre los diferentes procesos de configuración de la “ciudadanía” en relación a las necesidades históricas de cada contexto cultural, hace un análisis situado en el estado particular llamado Colombia, en el cual se promueve una ciudadanía política, es decir, se hace alusión a un marco jurídico para fomentar las formas como se deben establecer las relaciones con los otros para favorecer las dinámicas de consolidación de los gobiernos de turno. A partir de lo anterior se hace una reflexión sobre la necesidad de replantear la ciudadanía como condición humana, en el cual se potencien en los individuos sus elementos tanto sociales como culturales. Palabras clave: ciudadanía, ciudadano, humano, educación, participación. AbstractThis article, after tracing the different processes of configuration of "citizenship" in relation to the historical needs of each cultural context, makes an analysis located in the particular state called Colombia, in which political citizenship is promoted. In other words, a legal framework is used to encourage the ways in which relationships with others should be established in order to foster the dynamics of consolidation of the current governments. From the above, a reflection is made on the need to rethink citizenship as a human condition, in which individuals, both social and cultural, are empowered.Keywords: Citizenship, citizen, human, education, participation.Resumo Este artigo depois de fazer um rastreamento em processos de con guração diferentes “cidadania” em relação à necessi- dades históricas de cada contexto cultural, uma análise localizada no estado especial chamado Colômbia, em que cidadania política é promovida, isto é, referindo-se a um quadro legal é promover formas debe estabelecer relações com outros para promover a consolidação dinâmica de governos. a partir do acima é um re exo da

  19. A Paisagem como Imagem e Representação do Espaço na Geografia Humana

    Directory of Open Access Journals (Sweden)

    Marcio Pereira Santos

    2010-08-01

    Full Text Available Neste artigo procuramos dar uma base teórica mais aprofundada, assim como maior divulgação, a uma frente de pesquisa considerada pouco explorada na Geografia Humana, pela qual, a partir do paradigma do Espaço como objeto de estudo e da Paisagem como categoria de analise, defendemos à tese da Paisagem como sendo imagem e representação de espaço apropriado e produzido pelo homem. Utilizaremos, para tanto, fontes teóricas contemporâneas (Milton Santos, David Harvey, Gottdiener, etc. e da própria história do pensamento geográfico (Hartshorne, Carl sauer etc., assim como outras teorias das ciências humanas, sobretudo da Filosofia (Sartre, Wittgenstein, etc..

  20. Legitimidad de la Huelga de Hambre. Un debate sobre el derecho a la vida y la dignidad Humana

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    Jorge Precht Pizarro

    2013-01-01

    Full Text Available La huelga de hambre es una forma de protesta social, pacífica y extrema al mismo tiempo, en la que se tensionan valores esenciales del individuo, como la vida y la libertad, contenidos ambos en el núcleo mismo de la dignidad Humana. Sobre esta base, estudiamos los alcances de la huelga de hambre, desde sus fundamentos éticos esenciales hasta su dimensión jurídica y constitucional. Entre otros, se revisan los debates en materia de derechos fundamentales, algunas propuestas de tratamiento penal y las colisiones con los derechos de la infancia y adolescencia. En particular, se aborda el tratamiento jurisprudencial que le han dado los Tribunales Superiores de Justicia en Chile, formulando un juicio crítico, fundado en una ética de la Dignidad Humana y en las garantías fundamentales propiamente tales, frente a discutibles argumentaciones jurisprudenciales que han privilegiado soluciones contingentes.

  1. A utilização de imagens na identificação humana em odontologia legal

    OpenAIRE

    Suzana Papile Maciel Carvalho; Ricardo Henrique Alves da Silva; César Lopes-Júnior; Arsenio Sales Peres

    2009-01-01

    Este artigo de revisão sistemática tem por objetivo citar os métodos de identificação humana por meio da radiologia, utilizados em odontologia legal. Para isso, realizou-se revisão de literatura com 19 trabalhos selecionados dentre 45 encontrados, após aplicação de critérios de inclusão. Há diversas técnicas radiológicas que podem ser utilizadas para auxiliar na identificação humana, tanto individual como geral, incluindo a determinação do gênero, do grupo étnico e, principalmente, da idade. ...

  2. La reproducción humana en la revolución científico-técnica

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    Méndez Jiménez, Tito

    2008-01-01

    El artículo introduce la discusión filosófica sobre las relaciones hombre-­naturaleza, concretamente las referidas al proceso de reproducción humana en el marco del desarrollo precipitado y, muchas veces, caótico de la más compleja y poderosa fuerza humana de producción: La Revolución Científico-­Técnica (RCT). La argumentación objetiva y reflexión ontológica aquí planteadas y tendientes a demostrar la influencia negativa del despliegue irracional de la RCT en los mecanismos de reproducción h...

  3. A fundamentação da ciência da natureza humana de David Hume: uma epistemologia experimental

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    Campelo, Wendel de Holanda Pereira

    2013-01-01

    A ciência da natureza humana é o projeto de Hume que concerne à toda sua filosofia –estética, ética, política, teoria do conhecimento, história, economia, filosofia da religião, etc. – coisa de que jamais poderíamos dar conta, dado a natureza do trabalho de mestrado. Por isso, contentamo-nos em falar apenas da fundamentação da ciência da natureza humana, referente à investigação acerca da origem das ideias e operações do entendimento, ou da investigação sobre as causas e os poderes ocultos do...

  4. La vida humana como principio interpretativo radical en la filosofía de Ortega y Gasset

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    Antonio Gutiérrez-Pozo

    2012-12-01

    Full Text Available En este artículo presentamos el concepto de vida humana como texto eterno en el pensamiento de Ortega y sus consecuencias para el problema de la interpretación. La filosofía de la razón vital de Ortega se fundamenta en el concepto de vida humana como realidad radical y principio interpretativo universal, y por esta razón se presenta desde el principio como una filosofía hermenéutica de la vida y no como una reducción hacia la conciencia trascendental. Esta hermenéutica se practica especialmente en el ámbito del arte. Pero para Ortega todo texto es hermenéutico y necesita por tanto la interpretación, porque ningún texto posee en sí mismo su verdad.

  5. Estudio descriptivo de la presentación de brucelosis humana en Colombia desde 2000 hasta 2012

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    Patricia Lopez Guarnizo

    2014-07-01

    Full Text Available El objetivo de la investigación fue realizar un estudio descriptivo de la ocurrencia de brucelosis humana en Colombia entre 2000 y 2012, y con base en estudios previos conocer la prevalencia e incidencia de la enfermedad, las limitaciones para el diagnóstico oportuno y el reconocimiento de la enfermedad por el sistema laboral colombiano. La investigación se basó en la búsqueda y análisis de la información publicada en artículos relacionados con brucelosis humana entre 2000 y 2012 en Colombia. En esta investigación se incluyó una fase de recopilación de información y entrevistas no estructuradas a representantes de programas de control de brucelosis y a profesionales expertos. Se analizaron 17 trabajos de brucelosis humana realizados en el personal a riesgo en plantas de beneficio, expendedores y vacunadores del programa de brucelosis animal, en los cuales se reportaron 10 estudios con prevalencias entre 0,14 % y 10,4 % y 7 con seropositividad. En estos se encontró alguna información pertinente a las limitaciones del diagnóstico y se evidenció el poco conocimiento de la comunidad médica frente a la enfermedad. En Colombia no hay una política clara respecto a esta zoonosis de riesgo ocupacional. Solo se menciona la brucelosis en el Decreto 2566 de 2009, en la cual se adopta la nueva tabla de enfermedades profesionales. Se concluye que la brucelosis humana en Colombia es una enfermedad subdiagnosticada y, por lo tanto, subnotificada, ya que no existe un sistema de notificación obligatoria.

  6. Uso da eritropoetina recombinante humana no tratamento da anemia associada à insuficiência renal crônica

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    Carvalho, Mauricio de

    2013-01-01

    Resumo: A anemia acompanha a insuficiencia renal cronica e esta presente na maioria dos pacientes em dialise. O objetivo deste estudo foi analisar o efeito de seis meses de tratamento com a eritropoetina recombinante humana (EPO-rHu) na anemia associada a insuficiencia renal cronica terminal em vinte pacientes mantidos em programa de hemodialise. Os criterios de inclusao foram: pacientes que estivessem em hemodialise por pelo menos 3 meses, com idade maior que 18 ou menor que 70 anos; hematoc...

  7. Disfunción tiroidea relacionada a la progresión de la infección por el virus de inmunodeficiencia humana

    OpenAIRE

    Prener, Paola Claudia

    2015-01-01

    Objetivo general: Estudiar los niveles de Tirotrofina, hormonas tiroideas y autoanticuerpos como indicadores de disfunción tiroidea en pacientes portadores del virus de inmunodeficiencia humana HIV/SIDA que se atienden en el Servicio de Infectología del Hospital San Juan de Dios de La Plata. Objetivos específicos: 1. Analizar las características demográficas y clínicas en pacientes portadores del virus de inmunodeficiencia humana (HIV) internados y ambulatorios...

  8. Dignidade da pessoa humana e o décimo segundo camelo - sobre os limites da fundamentação de direitos

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    Sobottka, Emil Albert

    2008-01-01

    Full Text Available Dignidade da pessoa humana adquiriu em anos recentes um destaque como princípio fundamental a partir do qual são derivados direitos, considerados igualmente fundamentais. Com base na discussão provocada por Luhmann sobre recursos externos ao direito num sistema definido como operativamente fechado e cognitivamente aberto, o texto discute se a dignidade da pessoa humana consegue ocupar este lugar funcional

  9. Hacia una expectante significación de las acciones humanas en Jóvenes Agrópolis

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    Valentina Parra Ocampo

    2008-01-01

    Full Text Available El interés por plasmar en la realidad los estudios científicos propuestos desde el proyecto de investigación Discursos de la acción humana en la Psicología, que se empezó a realizar desde Waruma, el semillero de investigación de la Facultad de Psicología de la Universidad Santo Tomás y el interés de generar a partir de éste una propuesta al proyecto institucional e investigativo Jóvenes Aagrópolis que se desarrolla en el campo de Psicología de las Rrelaciones, Rredes y Nnarrativas, de la misma Facultad, llevó a visualizar la necesidad de generar una estrategia que permitiera resignificar y comprender la juventud a partir de su realidad humana y no desde los prejuicios y los rótulos a los que la ciencia y la sociedad la han tenido sometida. Eeste artículo plasma los antecedentes que dieron lugar al Instrumento de Análisis para la Significación de las Aacciones Humanas (IASAiasa, el cual hace parte de la metodología propuesta para la comprensión de una juventud como Jóvenes Aagrópolis.

  10. EL CONCEPTO DE VIDA «PREPERSONAL», EN EL FUTURO DE LA NATURALEZA HUMANA, DE J. HABERMAS

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    Roberto Germán Zurriaráin

    2005-01-01

    Full Text Available En este artículo se aborda el concepto de vida "prepersonal" en el libro de J. Habermas: El Futuro de la Naturaleza Humana. El autor sostiene que la vida prenatal es 2indisponible", pero no «inviolable». Habermas sostiene que el término "inviolabilidad" no es sinónimo de "indisponibilidad". El nacimiento, como acto socialmente individualizador, constituye a un organismo humano en una persona. La naturalidad del nacimiento desempeña el papel conceptualmente exigible de tal comienzo indisponible. Sin embargo, la vida humana prenatal no puede dejarse en manos de una ponderación de bienes que abra una ancha rendija a la instrumentalización de la vida. Por tanto, según Habermas, el estatuto ontológico de la vida "prepersonal", como individuo de la especie humana, radica no en lo que ya es en el vientre materno, sino en lo que será en el momento del nacimiento. El reconocimiento de la vida "prepersonal" proviene de lo que el ser humano será después del nacimiento.

  11. Paz y seguridad humana en África: una visión desde la Unión Africana

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    Jerónimo Delgado

    2009-11-01

    Full Text Available En este artículo se analizan las diferentes iniciativas que ha tenido el continente africano en materia de solución de conflictos y consolidación de la paz desde la perspectiva de la seguridad humana. En la primera parte, se identifican los componentes de la seguridad humana y los factores de inseguridad a los que se exponen los individuos en África, para luego examinar los avances del marco legal de la Unión Africana en la prevención de conflictos con énfasis en la seguridad de los individuos.La segunda parte contiene un estudio de las medidas enmarcadas dentro de la seguridad humana con las que cuentan los estados africanos y la comunidad internacional para la adecuada protección de los individuos, mientras se da un acercamiento entre las partes del conflicto para alcanzar el fin de las hostilidades. Finalmente, se afirma que África reconoce que la seguridad de sus ciudadanos es viable si se entienda que ésta es una responsabilidad compartida por todo el continente, en donde el individuo juega un papel central.

  12. Creencia en la benevolencia humana en delincuentes: un estudio inicial en función al delito

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    Susana V. Díaz Huamán

    2013-09-01

    Full Text Available Con una versión de la Escala de Creencia en la Benevolencia Humana, de Thomton y Kline (1982, 60 internos del Establecimiento Penitenciario "San Jorge" de Lima son evaluados para establecer si la creencia en la Benevolencia Humana varía en función del tipo de delito cometido, la condición jurídica, el tiempo de internamiento acumulado, la edad y el grado de instrucción. Los análisis estadísticos con la t de student y la r de Pearson muestran que, los internos que todavía no han sido sentenciados, los que tienen menor tiempo acumulado de internamiento, los de mayor edad y nivel de instrucción son los que evidencian mayor desconfianza en la benevolencia humana. Los autores presentan polémicas interpretaciones y conclusiones.Thomton and Kline (1982 Belief in Human Benevolence Scale is used to assess 60 subjects confined in a Penitentiary Institution. The main goal was to stablish if belief in human benevolence varies according to the type of transgression, juridical condition, time of confinement, age and instruction. Statistical results with t-student and r-Pearson show that prisoners that have not yet been jugded, that have less time in the institution and that are older and with higher instruccional level show a higher mistrust in human benevolence. Results are discussed.

  13. Papel de gestión humana en procesos de flexibilidad numérica en organizaciones colombianas

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    Ninfa Del Carmen Vega-Monsalve

    2014-12-01

    Full Text Available El fenómeno de la flexibilización numérica en Colombia -referida a la autonomía de la empresa para vincular y desvincular trabajadores de acuerdo con las demandas del mercado- nace con la llegada de algunas multinacionales que implementaban, en sus países de origen, medidas de desregularización laboral. Hoy, después de 30 años, se ha convertido en una práctica común en todo tipo de empresas. Sin embargo, no existía en el país un estudio empírico que comprendiera el papel que asume gestión humana frente al escenario de flexibilización laboral numérica. Este trabajo lo hace, desde un enfoque cualitativo de estudio de caso, de tipo descriptivo a profundidad y sobre una muestra de 22 empresas de Colombia. Los resultados mostraron que gestión humana está asumiendo un papel pasivo, en un ambiente que desvirtúa los principios de la flexibilidad contractual, plantea retos para los distintos actores y contribuye a la literatura centrada en la relación entre flexibilidad numérica y gestión humana.

  14. Visión humana y cristiana del desarrollo social: Benedicto XVI

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    José Luis Santos

    2013-05-01

    Full Text Available Un análisis sobre el desarrollo en una sociedad globalizada, según la visión cristiana desde el Evangelio, es expresado en su tercera encíclica 'Caritas in veritate', caridad en la verdad, (2009, por el Papa Benedicto XVI, Joseph Ratzinger, de reconocido sólido perfil teológico y magisterial. Caridad en la verdad en el cristianismo es principio operativo que trata de profundizar no en sentimientos marginales de la sociedad, sino en criterios orientadores, dos de ellos de máxima repercusión: la justicia y el bien común. Benedicto XVI considera el desarrollo humano en la reflexión actual, enumera previamente algunas desviaciones de gran alcance, bien conocidas en la esfera internacional, y extiende su mirada a continuación, desde la conciencia cristiana y desde la dimensión trascendente del hombre, sobre el hombre, sobre sus derechos y obligaciones en el progreso humano y sobre la familia humana global, centro y finalidad del desarrollo de los pueblos.

  15. Comunicación intercultural y ciencias humanas: una forma especial de encuentro

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    Solange Cárcamo Landero

    2009-07-01

    Full Text Available La comunicación intercultural, considerada como vivencia y experiencia auténtica de apertura hacia los Otros, es proyecto y método para la búsqueda de lo intercultural. Ella permite situar nuestras prácticas epistemológicas y metodológicas en el horizonte de una ciencia de la conversación profunda; cuyo desarrollo nos exige una redescripción holista de nuestras experiencias científicas para hacerlas menos etnocentristas. En este sentido, aquí ofrecemos una reflexión que conjuga el pensamiento de autores diversos (Panikkar, 2002; Taylor, 2005; Jaspers, 1980; Freire, 2003; Recasens, 2007; entre otros, para llegar a establecer como hipótesis transitoria que: la apertura intercultural de las ciencias humanas requiere de una epistemología de la concordia coherente con una metodología de la conversación a profundidad; que aquí concebimos como necesariamente intercultural.

  16. Disfunción tiroidea en adultos infectados por el virus de inmunodeficiencia humana

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    Erika Abelleira

    2014-08-01

    Full Text Available Los pacientes con infección por el virus de inmunodeficiencia humana (HIV tienen una mayor prevalencia de disfunción tiroidea cuando se los compara con la población general. Las manifestaciones más frecuentemente observadas son: el síndrome del eutiroideo enfermo, la enfermedad de Graves y el hipotiroidismo subclínico. La relación entre el uso de la terapia antirretroviral y el incremento en la prevalencia de alteraciones tiroideas fue demostrada en varias series de pacientes. La enfermedad de Graves se reconoce claramente como una consecuencia del síndrome de restitución inmune. Además, existen estudios que sugieren una relación entre hipotiroidismo y el uso de inhibidores nucleósidos de la transcriptasa reversa, en particular estavudina y el inhibidor no nucleósido de la transcriptasa reversa efavirenz. Nuevos estudios podrán aportar evidencia adicional sobre la necesidad de evaluaciones rutinarias de la función tiroidea en pacientes infectados por HIV.

  17. El hombre de maíz y la plasticidad humana

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    Bogin, Barry

    2001-01-01

    Full Text Available Una de las manifestaciones más obvias de la maleabilidad humana es la enorme variabilidad en estatura. A principios de este siglo la estatura media de una población fue considerada como un indicador genético. Por ejemplo los Maya de Guatemala, siendo de baja estatura, tendrían en este sentido una capacidad genética de crecimiento distinta a la de europeos y americanos. Los americanos eran los más altos del mundo, con una estatura media de 168 cm en varones. Actualmente, este "premio" pertenece a los holandeses con una estatura media de 180 cm en varones, mientras que el promedio de los americanos es de 177 cm. Al respecto debe notarse que hace escasos 100 años los holandeses fueron los europeos de más baja estatura. Para entender lo que sucedió con la estatura de holandeses y americanos tenemos que pensar en hombres y mujeres de maíz, es decir, en una especie que pueda adaptarse a los cambios ambientales por medio de modificaciones morfológicas en vez de esperar siglos para que ocurran cambios genéticos.

  18. O pensamento representacional e sua atualização nas ciências humanas

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    Eduardo Maurício Bomfim

    2012-04-01

    Full Text Available As ciências humanas ocupam um lugar particular na produção do conhecimento. Surgidas em decorrência de mudanças gerais na estrutura epistemológica e político-administrativa do século XIX, elas adquirem uma configuração específica que as localiza no cruzamento de vários outros saberes, como apontado pelo historiador Michel Foucault. Além disso, elas comportam outra peculiaridade, caracterizando-se em sua atividade por uma estreita relação com o que o filósofo Gilles Deleuze denomina de modelo da representação. A partir das análises de algumas obras destes dois pensadores, veremos como esses saberes operam uma atualização da representação por meio da normalização dos indivíduos.

  19. Paragonimiasis Humana Primera Descripción de un caso colombiano

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    Bernardo Buitrago

    1981-09-01

    Full Text Available Se describe el primer caso colombiano de Paragonimiasis humana, comprobado histopatológicamente, que afectó principalmente la base del pulmón derecho, comprometiendo por vecindad al hemidiafragma derecho y al hígado. La enfermedad del paciente fue, muy probablemente, adquirida en Mesetas, Meta y tuvo una evolución aproximada de 4 años; el paciente falleció durante el post-operatorio inmediato a la resección de las lesiones pleuro-pulmonares y hepáticas. La sintomatología fue la de una neumopatía crónica con tos hemoptoica y hemoptisis. A pesar de múltiples baciloscopías, iterativamente negativas para bacilo tuberculoso, al paciente se le diagnosticó y trató para Tuberculosis Pulmonar. En nuestro medio, la Paragonimiasis debe ser incluída dentro del diagnóstico diferencial de las neumopatías crónicas con tos hemoptoica y hemoptisis.

  20. Emocionalidad y moralidad en el debate sobre la clonación humana

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    Santiago Gabriel Calise

    2015-01-01

    Full Text Available El artículo que se presenta a continuación está dedicado al análisis de las emociones desplegadas en el debate bioético en torno del tema de la clonación humana. Al igual que respecto de otras innovaciones científicas que generan polémica, las posiciones suelen tender hacia el miedo o la esperanza. Aquí, a través de los conceptos de P. Livet, se pondrá el acento en el análisis de la relación entre las emociones desplegadas, los valores que estas emociones revelan y el proceso de revisión de las últimas. También será esencial analizar si realmente existe coherencia entre las emociones expresadas y los valores defendidos (identidad, dignidad, etc.. Ante su falta, se hablará, como señala Ogien, de pánico moral, situación en la cual, la puesta en escena de grandes reglas morales universales y de profundos sentimientos de indignación, esconde el rechazo a ir al fondo de las propias razones morales, por miedo a tener que admitir que los propios prejuicios se encuentran infundados.