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Sample records for corcoran joseph walsh

  1. Walsh Preprocessor.

    Science.gov (United States)

    1980-08-01

    exists a great many orthogonal functions such as the transforms of Laplace, Walsh, Haar , Karhunen-Loeve, plus the Z-Transform as well as the...and subtractors are ECL 4 bit arithmetic logic units (ALU) cascaded to accept the longer word lengths. The thirteen bit word is reduced to a ten bit...ttcring ) et i be accomplished in other orthogonal domains, such as Fourier, Haar , It: t emllac hier, etc. LNXI’lAN\\’I’ION OF NOIt’ATLIONS , ADAPTIVE11

  2. Contemporary discursive psychology: issues, prospects, and Corcoran's awkward ontology.

    Science.gov (United States)

    Potter, Jonathan

    2010-12-01

    This paper is both an overview of the status of contemporary discursive psychology and a response to Corcoran's critical article. The first part of the paper reports on the main traditions that make up contemporary discursive psychology and how they relate to one another. Then it responds to Corcoran's claims that much of contemporary discursive psychology: (a) is over concerned with epistemic issues at the expense of ontological issues; (b) is too concerned with data purity while failing reflexively to address its own practices; (c) fails to address ethical, applied, and political issues in the way that a reformed 'ontological' discursive psychology would be able to; (d) fails to provide an adequate and rich account of relationality (of the kind offered by thinkers such as Bakhtin, Shotter, and Chouliaraki). The limitations of each point are addressed in turn, highlighting errors and confusions. The broadly epistemic focus is appropriate for the subject matter of discursive psychology; discursive psychology is less concerned with data purity than with pursuing the radical and empirically progressive possibilities in studying records of people living their lives in everyday and institutional settings (a surprising oversight in a discipline focused on the actions of human beings) and it has a reflexive tradition going back two decades; it has a strong and distinctive focus on ethical, applied, and political issues; it has an account of relationality that is grounded in conversational materials. A single example from interaction on a child protection helpline is analysed to illustrate the way relationality, knowledge, and intersubjectivity have been made analytically tractable in contemporary discursive research.

  3. A Walsh Function Module Users' Manual

    Science.gov (United States)

    Gnoffo, Peter A.

    2014-01-01

    The solution of partial differential equations (PDEs) with Walsh functions offers new opportunities to simulate many challenging problems in mathematical physics. The approach was developed to better simulate hypersonic flows with shocks on unstructured grids. It is unique in that integrals and derivatives are computed using simple matrix multiplication of series representations of functions without the need for divided differences. The product of any two Walsh functions is another Walsh function - a feature that radically changes an algorithm for solving PDEs. A FORTRAN module for supporting Walsh function simulations is documented. A FORTRAN code is also documented with options for solving time-dependent problems: an advection equation, a Burgers equation, and a Riemann problem. The sample problems demonstrate the usage of the Walsh function module including such features as operator overloading, Fast Walsh Transforms in multi-dimensions, and a Fast Walsh reciprocal.

  4. Approximation by double Walsh polynomials

    Directory of Open Access Journals (Sweden)

    Ferenc Móricz

    1992-01-01

    Full Text Available We study the rate of approximation by rectangular partial sums, Cesàro means, and de la Vallée Poussin means of double Walsh-Fourier series of a function in a homogeneous Banach space X. In particular, X may be Lp(I2, where 1≦p<∞ and I2=[0,1×[0,1, or CW(I2, the latter being the collection of uniformly W-continuous functions on I2. We extend the results by Watari, Fine, Yano, Jastrebova, Bljumin, Esfahanizadeh and Siddiqi from univariate to multivariate cases. As by-products, we deduce sufficient conditions for convergence in Lp(I2-norm and uniform convergence on I2 as well as characterizations of Lipschitz classes of functions. At the end, we raise three problems.

  5. A-integrable martingale sequences and Walsh series

    International Nuclear Information System (INIS)

    Skvortsov, V A

    2001-01-01

    A sufficient condition for a Walsh series converging to an A-integrable function f to be the A-Fourier's series of f is stated in terms of uniform A-integrability of a martingale subsequence of partial sums of the Walsh series. Moreover, the existence is proved of a Walsh series that converges almost everywhere to an A-integrable function and is not the A-Fourier series of its sum

  6. A-integrable martingale sequences and Walsh series

    Energy Technology Data Exchange (ETDEWEB)

    Skvortsov, V A [M.V. Lomonosov Moscow State University, Moscow (Russian Federation)

    2001-06-30

    A sufficient condition for a Walsh series converging to an A-integrable function f to be the A-Fourier's series of f is stated in terms of uniform A-integrability of a martingale subsequence of partial sums of the Walsh series. Moreover, the existence is proved of a Walsh series that converges almost everywhere to an A-integrable function and is not the A-Fourier series of its sum.

  7. Dyadic Walsh analysis from 1924 onwards Walsh-Gibbs-Butzer dyadic differentiation in science

    CERN Document Server

    Stankovic, Radomir S; Schipp, Ferenc; Wade, William R; Su, Weiyi; Endow, Yasushi; Fridli, Sandor; Golubov, Boris I; Pichler, Franz

    2015-01-01

    Dyadic (Walsh) analysis emerged as a new research area in applied mathematics and engineering in early seventies within attempts to provide answers to demands from practice related to application of spectral analysis of different classes of signals, including audio, video, sonar, and radar signals. In the meantime, it evolved in a mature mathematical discipline with fundamental results and important features providing basis for various applications. The book will provide fundamentals of the area through reprinting carefully selected earlier publications followed by  overview of recent results concerning particular subjects in the area written by experts, most of them being founders of the field, and some of their followers. In this way, this first volume of the two volume book offers a rather complete coverage of the development of dyadic Walsh analysis, and provides a deep insight into its mathematical foundations necessary for consideration of generalizations and applications that are the subject of the se...

  8. Optical network security using unipolar Walsh code

    Science.gov (United States)

    Sikder, Somali; Sarkar, Madhumita; Ghosh, Shila

    2018-04-01

    Optical code-division multiple-access (OCDMA) is considered as a good technique to provide optical layer security. Many research works have been published to enhance optical network security by using optical signal processing. The paper, demonstrates the design of the AWG (arrayed waveguide grating) router-based optical network for spectral-amplitude-coding (SAC) OCDMA networks with Walsh Code to design a reconfigurable network codec by changing signature codes to against eavesdropping. In this paper we proposed a code reconfiguration scheme to improve the network access confidentiality changing the signature codes by cyclic rotations, for OCDMA system. Each of the OCDMA network users is assigned a unique signature code to transmit the information and at the receiving end each receiver correlates its own signature pattern a(n) with the receiving pattern s(n). The signal arriving at proper destination leads to s(n)=a(n).

  9. Application of Walsh functions to neutron transport problems. I. Theory

    International Nuclear Information System (INIS)

    Seed, T.J.; Albrecht, R.W.

    1976-01-01

    An approximation to the neutron transport equation is made by representing the angular flux with an expansion of the angular dependence in the orthogonal, complete, and binary valued sets of Walsh function. The Walsh approximation is applied to the one-speed, isotropic-scattering, rectangular-geometry form of the neutron transport equation. Sets of partial differential equations for the expansion coefficients are derived along with appropriate boundary conditions for their solution. The sets of the Walsh expansion to one- and two-dimensional forms of the transport equation are also obtained. The two-dimensional expansion coefficient equations are shown to be not only hyperbolic but also transformable to a set of S/sub N/-like equations that are coupled only through the scattering term. Such transformal sets of equations are termed Walsh-derived quadrature sets

  10. Far-field Diffraction Properties of Annular Walsh Filters

    Directory of Open Access Journals (Sweden)

    Pubali Mukherjee

    2013-01-01

    Full Text Available Annular Walsh filters are derived from the rotationally symmetric annular Walsh functions which form a complete set of orthogonal functions that take on values either +1 or −1 over the domain specified by the inner and outer radii of the annulus. The value of any annular Walsh function is taken as zero from the centre of the circular aperture to the inner radius of the annulus. The three values 0, +1, and −1 in an annular Walsh function can be realized in a corresponding annular Walsh filter by using transmission values of zero amplitude (i.e., an obscuration, unity amplitude and zero phase, and unity amplitude and phase, respectively. Not only the order of the Walsh filter but also the size of the inner radius of the annulus provides an additional degree of freedom in tailoring of point spread function by using these filters for pupil plane filtering in imaging systems. In this report, we present the far-field amplitude characteristics of some of these filters to underscore their potential for effective use in several demanding applications like high-resolution microscopy, optical data storage, microlithography, optical encryption, and optical micromanipulation.

  11. The Walsh Family Resilience Questionnaire: the Italian version.

    Science.gov (United States)

    Rocchi, Silvana; Ghidelli, Claudio; Burro, Roberto; Vitacca, Michele; Scalvini, Simonetta; Della Vedova, Anna Maria; Roselli, Gianmarco; Ramponi, Jean-Pierre; Bertolotti, Giorgio

    2017-01-01

    Resilience focuses on strength under stress, in the context of adversity. Walsh's theoretical model identifies relational processes that allow families to tackle and overcome critical situations, dividing them into three domains of family function. The aim of this study was to assess resilience in families of patients with a chronic disease by adapting and validating the Italian version of the Walsh Family Resilience Questionnaire (Walsh-IT). An Italian adult sample of 421 participants (patients and relatives) was collected with the aim to assess the reliability and validity of the Walsh-IT. Concurrent validity was carried out by comparing this instrument with the Family Adaptability and Cohesion Evaluation Scale III (FACES III) administered at the same time as the Walsh-IT. Reliability showed high correlation between repeated measurements. The alpha coefficient was 0.946. Both parallel analysis and minimum average partial criteria suggested that the best number of domains is equal to 3, explaining 50.4% of the total variance. Based on the results obtained from the Rasch analysis, items 10, 11, 16, 22, and 23 have been removed resulting in a short-form questionnaire (Walsh-IT-R) of 26 items with three domains: shared beliefs and support (SBS, α=0.928); family organization and interaction (FOI, α=0.863); and utilization of social resources (USR, α=0.567). The total score of the Walsh-IT-R was strongly correlated with the total score of FACES III Real Family Scale ( r =0.68; p family resilience in Italy when contending with the challenges of chronic disease. It could be used in pre- and post-assessment in practice effectiveness research, offering a profile of family resilience processes at the start and end of interventions and follow-up.

  12. Interview: Joseph Agassi

    Directory of Open Access Journals (Sweden)

    Joseph Agassi

    2016-12-01

    Full Text Available Joseph Agassi is an Israeli scholar born in Jerusalem on May 7, 1927. He has many books and articles published contributing to the fields of logic, scientific method, foundations of sciences, epistemology and, most importantly for this Journal, in the historiography of science. He studied with Karl Popper, who was definitely his biggest influence. He taught around the world in different universities. He currently lives in Herzliya, Israel. For his important contribution to the historiography of science, we chose to open the first issue of this journal with this interview recognizing his importance for the field, as well as paying our homage to him.

  13. Joseph Mountin Lecture

    Centers for Disease Control (CDC) Podcasts

    2009-10-26

    In this podcast, William H. Foege, MD, MPH delivers the 29th Annual Joseph W. Mountin Lecture. Dr. Foege was a key leader in the smallpox effort and worked as an epidemiologist in the successful eradication campaign in the 1970s. Dr. Foege became chief of the Smallpox Eradication Program at CDC, and was appointed director of CDC in 1977.  Created: 10/26/2009 by Centers for Disease Control and Prevention (CDC).   Date Released: 10/29/2009.

  14. Joseph Lister's first operation

    Science.gov (United States)

    Richardson, Ruth; Rhodes, Bryan

    2013-01-01

    Joseph Lister was still a medical student in 1851 when he served as house surgeon at University College Hospital, London, under John Erichsen. Here we report the first major operation that Lister accomplished, hitherto apparently missed by biographers. We chart his exemplary dealings with an emergency case of eviscerating stab wound in a woman brought to casualty at night, when he had been in post for less than a month. The case demonstrates Lister's fundamental competence at an early stage in his training. We outline the context of debate and controversy over the repair of lacerated gut at the time, and argue that Lister's period at University College London was profoundly formative.

  15. Joseph A. Schumpeter

    DEFF Research Database (Denmark)

    Andersen, Esben Sloth

    This book provides a comprehensive exploration of Joseph A. Schumpeter's research and theories, and in particular his theory of economic and social evolution as the real core of his work and academic life. Andersen demonstrates that the concept of innovative entrepreneurship is part...... of an evolutionary research programme, covering not only Schumpeter's account for economic growth and evolution but also his studies of the routinised economy, business cycles, socio-economic evolution, and the history of capitalism. The book thereby resolves apparent paradoxes and clarifies Schumpeter's challenge...

  16. Sir Francis Walshe, MD FRS (1885-1973).

    Science.gov (United States)

    Pearce, J M S

    2006-05-01

    Born in Ireland, Francis Martin Rouse Walshe studied medicine at University College Hospital. He subsequently practised there and at the National Hospital, Queen Square, London. Early associations with Wilfred Trotter and Sir Victor Horsley encouraged his career in Neurology. Walshe pioneered the descriptive analysis of human reflexes in physiological terms. His flare and outstanding brilliance were rewarded when he was appointed Physician to the National Hospital, Queen Square in 1921 and at University College Hospital in 1924. He published, mainly in Brain (which he edited for many years), weighty papers on the function of the cerebral cortex in relation to movements, and on neural physiology. Walshe is also remembered for his powers of literacy and stringent scientific criticism, which he often displayed with magnificent panache.

  17. Speech/Nonspeech Detection Using Minimal Walsh Basis Functions

    Directory of Open Access Journals (Sweden)

    Pwint Moe

    2007-01-01

    Full Text Available This paper presents a new method to detect speech/nonspeech components of a given noisy signal. Employing the combination of binary Walsh basis functions and an analysis-synthesis scheme, the original noisy speech signal is modified first. From the modified signals, the speech components are distinguished from the nonspeech components by using a simple decision scheme. Minimal number of Walsh basis functions to be applied is determined using singular value decomposition (SVD. The main advantages of the proposed method are low computational complexity, less parameters to be adjusted, and simple implementation. It is observed that the use of Walsh basis functions makes the proposed algorithm efficiently applicable in real-world situations where processing time is crucial. Simulation results indicate that the proposed algorithm achieves high-speech and nonspeech detection rates while maintaining a low error rate for different noisy conditions.

  18. Speech/Nonspeech Detection Using Minimal Walsh Basis Functions

    Directory of Open Access Journals (Sweden)

    Moe Pwint

    2006-10-01

    Full Text Available This paper presents a new method to detect speech/nonspeech components of a given noisy signal. Employing the combination of binary Walsh basis functions and an analysis-synthesis scheme, the original noisy speech signal is modified first. From the modified signals, the speech components are distinguished from the nonspeech components by using a simple decision scheme. Minimal number of Walsh basis functions to be applied is determined using singular value decomposition (SVD. The main advantages of the proposed method are low computational complexity, less parameters to be adjusted, and simple implementation. It is observed that the use of Walsh basis functions makes the proposed algorithm efficiently applicable in real-world situations where processing time is crucial. Simulation results indicate that the proposed algorithm achieves high-speech and nonspeech detection rates while maintaining a low error rate for different noisy conditions.

  19. On L1-convergence of Walsh-Fourier series

    Directory of Open Access Journals (Sweden)

    C. W. Onneweer

    1978-01-01

    Full Text Available Let G denote the dyadic group, which has as its dual group the Walsh(-Paley functions. In this paper we formulate a condition for functions in L1(G which implies that their Walsh-Fourier series converges in L1(G-norm. As a corollary we obtain a Dini-Lipschitz-type theorem for L1(G convergence and we prove that the assumption on the L1(G modulus of continuity in this theorem cannot be weakened. Similar results also hold for functions on the circle group T and their (trigonometric Fourier series.

  20. The Walsh Family Resilience Questionnaire: the Italian version

    Directory of Open Access Journals (Sweden)

    Rocchi S

    2017-12-01

    Full Text Available Silvana Rocchi,1 Claudio Ghidelli,2 Roberto Burro,3 Michele Vitacca,4 Simonetta Scalvini,5 Anna Maria Della Vedova,6 Gianmarco Roselli,7 Jean-Pierre Ramponi,8 Giorgio Bertolotti9 1Psychology Service, ICS Maugeri Spa SB, Institute of Lumezzane, 2Psychological Counselling Service, Università Cattolica del Sacro Cuore, Brescia, 3Department of Human Sciences, University of Verona, Verona, 4Respiratory Rehabilitation Division, 5Cardiac Rehabilitation Division, ICS Maugeri Spa SB, Institute of Lumezzane, 6Department of Clinical and Experimental Sciences, University of Brescia, 7Department of Mental Health, Spedali Civili, 8ICS Maugeri Spa SB, Institute of Lumezzane, Brescia, 9Psychology Unit, ICS Maugeri Spa SB, Institute of Tradate, Varese, Italy Background: Resilience focuses on strength under stress, in the context of adversity. Walsh’s theoretical model identifies relational processes that allow families to tackle and overcome critical situations, dividing them into three domains of family function. The aim of this study was to assess resilience in families of patients with a chronic disease by adapting and validating the Italian version of the Walsh Family Resilience Questionnaire (Walsh-IT. Patients and methods: An Italian adult sample of 421 participants (patients and relatives was collected with the aim to assess the reliability and validity of the Walsh-IT. Concurrent validity was carried out by comparing this instrument with the Family Adaptability and Cohesion Evaluation Scale III (FACES III administered at the same time as the Walsh-IT. Results: Reliability showed high correlation between repeated measurements. The alpha coefficient was 0.946. Both parallel analysis and minimum average partial criteria suggested that the best number of domains is equal to 3, explaining 50.4% of the total variance. Based on the results obtained from the Rasch analysis, items 10, 11, 16, 22, and 23 have been removed resulting in a short-form questionnaire

  1. Joseph Lister's surgical revolution.

    Science.gov (United States)

    Toledo-Pereyra, Luis H

    2010-10-01

    Joseph Lister (1827-1912), renowned British surgeon-scientist, introduced to the world the use and appreciation of the antiseptic method for the prevention of wound sepsis. Armed with the ideas of Louis Pasteur (1822-1895) regarding the role of microorganisms in infections or the so-called germ theory of disease, he advanced the surgical field by using antiseptics, such as carbolic acid, in the treatment of contaminated wounds. These developments constituted a real surgical revolution. No breakthrough before Lister's, except perhaps the discovery of anesthesia, had contributed to such an incredible advancement in relationship to the surgical arena. After 1867, the year in which Lister published his remarkable paper in Lancet, it was possible to appropriately treat or prevent wound infections with the use of antiseptics at the site of the operated wound. Lister's method was complicated but produced its desired effect--to diminish wound morbidity and patient mortality. His contribution was secured for future generations and a surgical revolution had begun!

  2. Joseph (Joe) A. Walker

    Science.gov (United States)

    1956-01-01

    In March 1945 Joseph A. Walker joined the National Advisory Committee for Aeronautics' Aircraft Engine Research Laboratory, Cleveland, Ohio, (later NASA's Lewis Research Center, now the Glenn Research Center) as a physicist. He transferred to the NACA High-Speed Flight Research Station, Edwards, California in 1951, as a research pilot. For the next fifteen years Walker served as a pilot at the Edwards flight research facility (today known as NASA's Dryden Flight Research Center) on such projects as the Bell X-1#2 (2 flights, first on August 27, 1951), Bell X-1A (1 flight on July 20, 1955), X-1E (21 flights, first on December 12, 1955), Douglas D-558-I #3 Skystreak (14 flights, first on June 29, 1951), Douglas D-558-II #2 Skyrocket (3 flights, first on April 29, 1955), Douglas D-558-II #3 Skyrocket (2 flights, first on May 7, 1954). On the Douglas X-3, Joe was project pilot and made all 20 flights, the first on August 1, 1954. Joe considered this aircraft the 'worst' plane he ever flew. He flew the Northrup X-4 (2 flights, first on October 18, 1951), Bell X-5 (78 flights, first on January 9, 1952). He also flew programs involving the F-100, F-101, F-102, F-104 and the B-47. Walker made the first NASA flight on the North American X-15 on March 25, 1960. His 25th and final X-15 flight on August 22, 1963, reached 354,200 feet, an unofficial record altitude of almost 67 miles. On October 30, 1964, Walker took the first Bell Lunar Landing Research Vehicle (LLRV) on its maiden flight, reaching a peak altitude of 10 feet and a free flight time of just under one minute. Two LLRV's and three Lunar Landing Training Vehicles developed from them were used to develop piloting and operational techniques for lunar landings. In November, he left the program after 35 flights on the first LLRV. Walker flew chase flights as well as research flights. On June 8, 1966 he was flying chase in NASA's F-104N for the Air Force's experimental bomber, North American XB-70A, when he was fatally

  3. Approximation by weighted means of Walsh-Fourier series

    Directory of Open Access Journals (Sweden)

    F. Móricz

    1996-01-01

    Full Text Available We study the rate of approximation to functions in Lp and, in particular, in Lip(α,p by weighted means of their Walsh-Fourier series, where α>0 and 1≤p≤∞. For the case p=∞, Lp is interpreted to be CW, the collection of uniformly W continuous functions over the unit interval [0,1. We also note that the weighted mean kernel is quasi-positive, under fairly general conditions.

  4. Spectrums Transform Operators in Bases of Fourier and Walsh Functions

    Directory of Open Access Journals (Sweden)

    V. V. Syuzev

    2017-01-01

    Full Text Available The problems of synthesis of the efficient algorithms for digital processing of discrete signals require transforming the signal spectra from one basis system into other. The rational solution to this problem is to construct the Fourier kernel, which is a spectrum of some basis functions, according to the system of functions of the other basis. However, Fourier kernel properties are not equally studied and described for all basis systems of practical importance. The article sets a task and presents an original way to solve the problem of mutual transformation of trigonometric Fourier spectrum into Walsh spectrum of different basis systems.The relevance of this theoretical and applied problem is stipulated, on the one hand, by the prevalence of trigonometric Fourier basis for harmonic representation of digital signals, and, on the other hand, by the fact that Walsh basis systems allow us to have efficient algorithms to simulate signals. The problem solution is achieved through building the Fourier kernel of a special structure that allows us to establish independent groups of Fourier and Walsh spectrum coefficients for further reducing the computational complexity of the transform algorithms.The article analyzes the properties of the system of trigonometric Fourier functions and shows its completeness. Considers the Walsh function basis systems in three versions, namely those of Hadamard, Paley, and Hartmut giving different ordering and analytical descriptions of the functions that make up the basis. Proves a completeness of these systems.Sequentially, for each of the three Walsh systems the analytical curves for the Fourier kernel components are obtained, and Fourier kernel themselves are built with binary rational number of samples of basis functions. The kernels are presented in matrix form and, as an example, recorded for a particular value of the discrete interval of N, equal to 8. The analysis spectral coefficients of the Fourier kernel

  5. Joseph Goebbels. Cartel y propaganda

    OpenAIRE

    Martínez Ceballos, Verónica

    2016-01-01

    Análisis de la propaganda en la Segunda Guerra Mundial con su máximo impulsor, Joseph Goebbels, analizando la cartelería producida durante el régimen nazi. Este análisis se efectuará desde una visión histórica y social, en el que se indagará en Joseph Goebbels, los medios de comunicación y las características del cartel nazi para comprender la utilización de la propaganda, el uso del cartel y la intención comunicativa que esperaban de ellos. Grado en Publicidad y Relaciones Púb...

  6. Where was Joseph Babinski born?

    Directory of Open Access Journals (Sweden)

    H A G Teive

    2011-01-01

    Full Text Available There is controversy in the neurological literature about where Joseph Babinski was born, including a myth propounded by various important authors that he was born in Lima, Peru. However, according to the most consistent biographical data, he was in fact born in Paris, France, and became a medical celebrity there and in Poland as well as around the world.

  7. Joseph Hooker: a philosophical botanist

    Indian Academy of Sciences (India)

    2008-04-24

    Apr 24, 2008 ... Keywords. History of botany; Hooker Joseph Dalton; imperial science; philosophical botany ... However, he preferred to refer to himself as a philosophical botanist, rather than a professional. This paper explores the reasons for this choice, and analyses Hooker's imperial approach to plant classification, the ...

  8. Joseph Hooker: a philosophical botanist

    Indian Academy of Sciences (India)

    2008-04-24

    Apr 24, 2008 ... The nineteenth-century British botanist, Joseph Dalton Hooker, was one of the people whose career became a model for that of the modern, professional scientist. However, he preferred to refer to himself as a philosophical botanist, rather than a professional. This paper explores the reasons for this choice, ...

  9. Brumpt, Prof. Emile Joseph Alexandre

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1936 Honorary. Brumpt, Prof. Emile Joseph Alexandre. Date of birth: 10 March 1877. Date of death: 8 July 1951. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be ...

  10. Brumpt, Prof. Emile Joseph Alexandre

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1936 Honorary. Brumpt, Prof. Emile Joseph Alexandre. Date of birth: 10 March 1877. Date of death: 8 July 1951. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of ...

  11. Some remarks concerning the usage of Walsh transformation in picture processing

    International Nuclear Information System (INIS)

    Schiller, H.; Wille, M.J.

    1976-01-01

    It is shown that after the Walsh transformation of a straight line (e.g. of a track of a bubble chamber picture) it is possible to get information about the position of the line using Walsh coefficients. With the sequential information reduction one can easily suppress the noise of a bubble chamber picture. (author)

  12. 48 CFR 52.222-20 - Walsh-Healey Public Contracts Act.

    Science.gov (United States)

    2010-10-01

    ... in solicitations and contracts covered by the Act: Walsh-Healey Public Contracts Act (OCT 2010) If this contract is for the manufacture or furnishing of materials, supplies, articles or equipment in an... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Walsh-Healey Public...

  13. Unsteady Solution of Non-Linear Differential Equations Using Walsh Function Series

    Science.gov (United States)

    Gnoffo, Peter A.

    2015-01-01

    Walsh functions form an orthonormal basis set consisting of square waves. The discontinuous nature of square waves make the system well suited for representing functions with discontinuities. The product of any two Walsh functions is another Walsh function - a feature that can radically change an algorithm for solving non-linear partial differential equations (PDEs). The solution algorithm of non-linear differential equations using Walsh function series is unique in that integrals and derivatives may be computed using simple matrix multiplication of series representations of functions. Solutions to PDEs are derived as functions of wave component amplitude. Three sample problems are presented to illustrate the Walsh function series approach to solving unsteady PDEs. These include an advection equation, a Burgers equation, and a Riemann problem. The sample problems demonstrate the use of the Walsh function solution algorithms, exploiting Fast Walsh Transforms in multi-dimensions (O(Nlog(N))). Details of a Fast Walsh Reciprocal, defined here for the first time, enable inversion of aWalsh Symmetric Matrix in O(Nlog(N)) operations. Walsh functions have been derived using a fractal recursion algorithm and these fractal patterns are observed in the progression of pairs of wave number amplitudes in the solutions. These patterns are most easily observed in a remapping defined as a fractal fingerprint (FFP). A prolongation of existing solutions to the next highest order exploits these patterns. The algorithms presented here are considered a work in progress that provide new alternatives and new insights into the solution of non-linear PDEs.

  14. The birth of joseph gabriel.

    Science.gov (United States)

    Cantine, Anne Touhill

    2013-01-01

    In this column, a mother shares the story of the birth of her first child. With confidence in the process of birth and in her ability to give birth, and with the support, confidence, and encouragement of her mother and sisters, Anne manages to cope with strong contractions through a busy day. Finally, her husband realizes how fast labor is progressing. Baby Joseph was born less than 2 hours after arrival at the hospital.

  15. Note on the Solution of Transport Equation by Tau Method and Walsh Functions

    Directory of Open Access Journals (Sweden)

    Abdelouahab Kadem

    2010-01-01

    Full Text Available We consider the combined Walsh function for the three-dimensional case. A method for the solution of the neutron transport equation in three-dimensional case by using the Walsh function, Chebyshev polynomials, and the Legendre polynomials are considered. We also present Tau method, and it was proved that it is a good approximate to exact solutions. This method is based on expansion of the angular flux in a truncated series of Walsh function in the angular variable. The main characteristic of this technique is that it reduces the problems to those of solving a system of algebraic equations; thus, it is greatly simplifying the problem.

  16. Redox Pioneer: Professor Joseph Loscalzo

    OpenAIRE

    Leopold, Jane A.

    2010-01-01

    Dr. Joseph Loscalzo (M.D., 1978; Ph.D., 1977) is recognized here as a Redox Pioneer because he has published two articles in the field of antioxidant/redox biology that have been cited more than 1,000 times and 22 articles that have been cited more than 100 times. Dr. Loscalzo is known for his seminal contributions to our understanding of the vascular biology of nitric oxide. His initial discovery that the antiplatelet effects of organic nitrates are potentiated by thiols through a mechanism ...

  17. Representation of American versus non-American fans in Baillie Walsh's Springsteen & I

    NARCIS (Netherlands)

    Wilkinson, M.C.

    2015-01-01

    This article explores the representation of American versus non-American fans in Baillie Walsh's 2013 crowd/fan-sourced documentary Springsteen & I. The film—as much as it was fed by a wide and international range of fan-produced material—ultimately produced and presented one particular type of fan

  18. "A Chance Child": Jill Paton Walsh and the Re-Invention of the Time Slip Story

    Science.gov (United States)

    Hall, Linda Marian

    2011-01-01

    In this study of Jill Paton Walsh's one time-slip novel, I attempt to show how she reinvents the genre by giving as much prominence to the dislocated present as she does to the sufferings of children caught up in the horrors of the Industrial Revolution. Where previous time-slip authors had concentrated on the past, she addresses clearly unwelcome…

  19. 75 FR 32742 - Action Affecting Export Privileges; Joseph Piquet

    Science.gov (United States)

    2010-06-09

    ...: Joseph Piquet 76067-004 currently incarcerated at FDI Miami, Federal Detention Center, P.O. Box 019120.... Until May 14, 2019, Joseph Piquet, with a last known address at: 76067-004, FDI Miami, Federal Detention...

  20. Wiring of patellar fractures by Joseph Lister.

    Science.gov (United States)

    Ellis, Harold

    2016-01-01

    Joseph Lister (1827-1912) was the father of modern surgery and, in particular, of today's orthopaedic surgery. Before Lister, surgeons seldom opened into a joint or performed an open operation for failed reduction or malunion of a fracture. Indeed, most surgical teachers condemned such procedures because of the almost invariable complications of wound suppuration, pyaemia prolonged illness and often death.

  1. Verlossing: van Pelagius tot Joseph Smith

    Directory of Open Access Journals (Sweden)

    H.F. van Wyk

    2010-07-01

      During this time Joseph Smith started to seek the true church and founded the Mormon Church. Although his theology differs quite strongly from the Methodist Church in which he grew up, the core of the way of salvation is the same: man has free will in choosing his salvation.

  2. Feature Detection and Curve Fitting Using Fast Walsh Transforms for Shock Tracking: Applications

    Science.gov (United States)

    Gnoffo, Peter A.

    2017-01-01

    Walsh functions form an orthonormal basis set consisting of square waves. Square waves make the system well suited for detecting and representing functions with discontinuities. Given a uniform distribution of 2p cells on a one-dimensional element, it has been proven that the inner product of the Walsh Root function for group p with every polynomial of degree fit to distributions across the element that include a discontinuity. The detection of a discontinuity enables analytic relations to locally describe its evolution and provide increased accuracy. Time accurate examples are provided for advection, Burgers equation, and Riemann problems (diaphragm burst) in closed tubes and de Laval nozzles. New algorithms to detect up to two C0 and/or C1 discontinuities within a single element are developed for application to the Riemann problem, in which a contact discontinuity and shock wave form after the diaphragm bursts.

  3. A Tribute to Joseph M. Lookofsky

    DEFF Research Database (Denmark)

    of Law, 1971). He became a member of the New York State Bar and started his professional career as an attorney for the United Artists Corporation, specializing in contract law and copyright law. In 1973 he married a Danish woman, Vibeke, and moved to Denmark. He then took a Danish law degree (cand......This book is a tribute to Professor Joseph M. Lookofsky, honoring his work as an internationally respected scholar within the areas of private law, comparative law and private international law. It contains contributions from a wide range of respected scholars and colleagues from around the globe...... on topics like the United Nations Convention on the International Sale of Goods (the CISG), Arbitration and Private International Law. Joseph M. Lookofsky was born in in 1945 in New York, USA, where he studied economics (B.A. Economics, Lehigh University, 1967) and law (J.D., New York University School...

  4. Faith According to Cardinal Joseph Ratzinger

    Directory of Open Access Journals (Sweden)

    Wojciech Zyzak

    2013-04-01

    Full Text Available The subject of this article is faith according to Cardinal Joseph Ratzinger, the present Pope Benedict XVI. At the beginning the author presents the Cardinal’s diagnosis of the state of faith in the contemporary world. Joseph Ratzinger shows both positive and negative features of this state. After having presented the sociological aspect, the author deals with the essence of the faith according to Ratzinger. The further analysis concern the sacramental dimension of the Christian faith. Because the real faith is necessarily the faith of the Church, the article also indicates its communion dimension. The author additionally discusses a very important topic concerning the relation of faith to reason and truth. At the end of the article the reader can find the teaching of Cardinal about the relation between faith and history.

  5. On an analogue of Hardy's inequality for the Walsh-Fourier

    International Nuclear Information System (INIS)

    Golubov, B I

    2001-01-01

    According to Hardy's well-known inequality, the l 1 -norm of a function in the Hardy space H(t) consisting of 2π-periodic functions serves as an upper estimate for the l 1 -norm of the sequence of Fourier coefficients of the integral of the function. In this paper, the dyadic Hardy space H(R + ) is introduced and an analogue of this estimate is proved for the Walsh-Fourier transform

  6. The Cascading Haar Wavelet Algorithm for Computing the Walsh-Hadamard Transform

    Science.gov (United States)

    Thompson, Andrew

    2017-07-01

    We propose a novel algorithm for computing the Walsh-Hadamard Transform (WHT) which consists entirely of Haar wavelet transforms. We prove that the algorithm, which we call the Cascading Haar Wavelet (CHW) algorithm, shares precisely the same serial complexity as the popular divide-and-conquer algorithm for the WHT. We also propose a natural way of parallelizing the algorithm which has a number of attractive features.

  7. An Improved Walsh Function Algorithm for Use in Sinusoidal and Nonsinusoidal Power Components Measurement

    Directory of Open Access Journals (Sweden)

    Saifulnizam Bin Abdul Khalid

    2013-01-01

    Full Text Available This paper presents an improved Walsh function IWF algorithms as an alternative approach for active and reactive powers measurement in linear and nonlinear, balanced and unbalanced sinusoidal three-phase load system. It takes advantage of Walsh function unified approach, simple algorithm and its intrinsic high level of accuracy as a result of coefficient characteristics and energy behaviour representation. The developed algorithm was modeled on the Matlab Simulink software; different types of load, linear and nonlinear, were also modeled based on practical voltage and current waveforms and tested with the proposed improved Walsh algorithms. The IEEE standard 1459–2000 which is based on fast Fourier transform FFT approach was used as benchmark for the linear load system. The data obtained from laboratory experiment to determine power components in harmonic load systems using Fluke 435 power quality analyzer PQA which complies with IEC/EN61010-1-2001 standard was modeled and used to validate the improved algorithm for nonlinear load measurement. The results showed that the algorithm has the potential to effectively measure three-phase power components under different load conditions.

  8. Dan Joseph's contributions to disperse multiphase flow

    Science.gov (United States)

    Prosperetti, Andrea

    2012-11-01

    During his distinguished career, Dan Joseph worked on a vast array of problems. One of these, which occupied him off and on over the last two decades of his life, was that of flows with suspended finite-size particles at finite Reynolds numbers. He realized early on that progress in this field had to rely on the insight gained from numerical simulation, an area in which he was a pioneer. On the basis of the early numerical results he recognized the now famous ``drafting, kissing and tumbling'' mechanism of particle-particle interaction, the possibility of fluidization by lift and many others. With a number of colleagues and a series of gifted students he produced a significant body of work summarized in his on-line book Interrogations of Direct Numerical Simulation of Solid-Liquid Flows available from http://www.efluids.com/efluids/books/joseph.htm. This presentation will describe Joseph's contribution to the understanding of disperse multiphase flow and conclude with some examples from the author's recent work in this area. Supported by NSF.

  9. Equalization of Multiuser Wireless CDMA Downlink Considering Transmitter Nonlinearity Using Walsh Codes

    Directory of Open Access Journals (Sweden)

    Pinter Stephen Z

    2007-01-01

    Full Text Available Transmitter nonlinearity has been a major issue in many scenarios: cellular wireless systems have high power RF amplifier (HPA nonlinearity at the base station; satellite downlinks have nonlinear TWT amplifiers in the satellite transponder and multipath conditions in the ground station; and radio-over-fiber (ROF systems consist of a nonlinear optical link followed by a wireless channel. In many cases, the nonlinearity is simply ignored if there is no out-of-band emission. This results in poor BER performance. In this paper we propose a new technique to estimate the linear part of the wireless downlink in the presence of a nonlinearity using Walsh codes; Walsh codes are commonly used in CDMA downlinks. Furthermore, we show that equalizer performance is significantly improved by taking into account the presence of the nonlinearity during channel estimation. This is shown by using a regular decision feedback equalizer (DFE with both wireless and RF amplifier noise. We perform estimation in a multiuser CDMA communication system where all users transmit their signal simultaneously. Correlation analysis is applied to identify the channel impulse response (CIR and the derivation of key correlation relationships is shown. A difficulty with using Walsh codes in terms of their correlations (compared to PN sequences is then presented, as well as a discussion on how to overcome it. Numerical evaluations show a good estimation of the linear system with 54 users in the downlink and a signal-to-noise ratio (SNR of 25 dB. Bit error rate (BER simulations of the proposed identification and equalization algorithms show a BER of achieved at an SNR of dB.

  10. Equalization of Multiuser Wireless CDMA Downlink Considering Transmitter Nonlinearity Using Walsh Codes

    Directory of Open Access Journals (Sweden)

    Stephen Z. Pinter

    2007-02-01

    Full Text Available Transmitter nonlinearity has been a major issue in many scenarios: cellular wireless systems have high power RF amplifier (HPA nonlinearity at the base station; satellite downlinks have nonlinear TWT amplifiers in the satellite transponder and multipath conditions in the ground station; and radio-over-fiber (ROF systems consist of a nonlinear optical link followed by a wireless channel. In many cases, the nonlinearity is simply ignored if there is no out-of-band emission. This results in poor BER performance. In this paper we propose a new technique to estimate the linear part of the wireless downlink in the presence of a nonlinearity using Walsh codes; Walsh codes are commonly used in CDMA downlinks. Furthermore, we show that equalizer performance is significantly improved by taking into account the presence of the nonlinearity during channel estimation. This is shown by using a regular decision feedback equalizer (DFE with both wireless and RF amplifier noise. We perform estimation in a multiuser CDMA communication system where all users transmit their signal simultaneously. Correlation analysis is applied to identify the channel impulse response (CIR and the derivation of key correlation relationships is shown. A difficulty with using Walsh codes in terms of their correlations (compared to PN sequences is then presented, as well as a discussion on how to overcome it. Numerical evaluations show a good estimation of the linear system with 54 users in the downlink and a signal-to-noise ratio (SNR of 25 dB. Bit error rate (BER simulations of the proposed identification and equalization algorithms show a BER of 10−6 achieved at an SNR of ∼25 dB.

  11. Ludwig Boltzmann, Albert Einstein and Franz Joseph

    International Nuclear Information System (INIS)

    Broda, E.

    1983-01-01

    Under the Emperor Francis Joseph (1848-1916) the natural sciences were less weIl supported in Austria than in other countries of Europe. This is explained by the fact that the German speaking middle classes accepted the preeminence of the feudal forces with their antiscientific attitude. The reason for this readiness to subordination was that those middle classes feIt threatened in their relatively favourable situation by Slavs and Latins. Francis Joseph was the typical representative of the aristocracy. Personally, he did his duty conscientiously and was not corrupt, but progressive ideas and scientific thought were alien to him. From his desk he treated Boltzmann benevolently, but he had no wish to meet personally the greatest mind of the Empire or in any respect to ask his views. Another famous subject of the Emperor, Albert Einstein, was apparently ignored altogether. The structural weakness of Austria, due to the national problems, led to immobilism in her scientific life, but also, up to a point, to tolerance. The impression of Victor Adler on Einstein is considered in this historical context. (author) [de

  12. Objetividad: la construcción de la verdad en Rodolfo Walsh

    OpenAIRE

    Vallina, Carlos Alberto; Gómez, Lía G.

    2017-01-01

    La escritura de Rodolfo Walsh presenta funciones diversas del campo comunicacional: informar, contrainformar, revelar el ocultamiento de los medios masivos concentrados e incorporar técnicas de múltiples géneros, como los periódicos populares, los canales alternativos de circulación y los registros perceptuales del habla social, específicamente de la vida real de los trabajadores industriales y campesinos. La construcción de un nuevo significante abierto que surge de esas interacciones, otorg...

  13. Rodolfo Walsh: un ejemplo de lucha integral : Apuntes sobre experiencias colectivas y matrices populares

    OpenAIRE

    Leavi Gardoni, Carlos

    2007-01-01

    Rodolfo Walsh fue protagonista de una de las organizaciones más importantes de nuestro movimiento obrero: la CGT de los argentinos. Su rol explícito: director del semanario CGT, órgano de difusión de la central obrera desde su creación, en mayo de 1968. Su rol real: militante integral en la construcción de alternativas políticas, sean sindicales, culturales o periodísticas, para transformar y revolucionar la realidad social y económica de nuestro país. Facultad de Periodismo y Comunicación...

  14. The perforamance of genetic algorithms on Walsh polynomials: Some anomalous results and their explanation

    International Nuclear Information System (INIS)

    Forrest, S.

    1991-01-01

    In this paper we discuss a number of seemingly anomalous results reported by Tanese concerning the performance of the genetic algorithm (GA) on a subclass of Walsh polynomials. Tanese found that the GA optimized these functions poorly and that a partitioning of a single large population into a number of smaller independent populations seemed to improve performance. We reexamine these results experimentally and theoretically, and propose and evaluate some explanations. In addition, we examine the question of what are reasonable and appropriate ways to measure the performance of genetic algorithms. 11 refs., 1 tab

  15. Rotated Walsh-Hadamard Spreading with Robust Channel Estimation for a Coded MC-CDMA System

    Directory of Open Access Journals (Sweden)

    Raulefs Ronald

    2004-01-01

    Full Text Available We investigate rotated Walsh-Hadamard spreading matrices for a broadband MC-CDMA system with robust channel estimation in the synchronous downlink. The similarities between rotated spreading and signal space diversity are outlined. In a multiuser MC-CDMA system, possible performance improvements are based on the chosen detector, the channel code, and its Hamming distance. By applying rotated spreading in comparison to a standard Walsh-Hadamard spreading code, a higher throughput can be achieved. As combining the channel code and the spreading code forms a concatenated code, the overall minimum Hamming distance of the concatenated code increases. This asymptotically results in an improvement of the bit error rate for high signal-to-noise ratio. Higher convolutional channel code rates are mostly generated by puncturing good low-rate channel codes. The overall Hamming distance decreases significantly for the punctured channel codes. Higher channel code rates are favorable for MC-CDMA, as MC-CDMA utilizes diversity more efficiently compared to pure OFDMA. The application of rotated spreading in an MC-CDMA system allows exploiting diversity even further. We demonstrate that the rotated spreading gain is still present for a robust pilot-aided channel estimator. In a well-designed system, rotated spreading extends the performance by using a maximum likelihood detector with robust channel estimation at the receiver by about 1 dB.

  16. Detection of an apple-infesting popoulation of Rhagoletis pomonella (Walsh) 1867 (Diptera: Tephritidae) in the state of Colorado, USA

    Science.gov (United States)

    The apple maggot fly, Rhagoletis pomonella (Walsh) 1867 (Tephritidae), is an economically important pest of apples (Malus domesica Borkh.) (Rosaceae) throughout much of the United States. The fly is endemic to the eastern U.S., where its primary host plants are several species of native hawthorns (C...

  17. 29 CFR 1926.15 - Relationship to the Service Contract Act; Walsh-Healey Public Contracts Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Relationship to the Service Contract Act; Walsh-Healey Public Contracts Act. 1926.15 Section 1926.15 Labor Regulations Relating to Labor (Continued... materials, supplies, articles or equipment to be manufactured or furnished under said contract be...

  18. Performance enhancement of optical code-division multiple-access systems using transposed modified Walsh code

    Science.gov (United States)

    Sikder, Somali; Ghosh, Shila

    2018-02-01

    This paper presents the construction of unipolar transposed modified Walsh code (TMWC) and analysis of its performance in optical code-division multiple-access (OCDMA) systems. Specifically, the signal-to-noise ratio, bit error rate (BER), cardinality, and spectral efficiency were investigated. The theoretical analysis demonstrated that the wavelength-hopping time-spreading system using TMWC was robust against multiple-access interference and more spectrally efficient than systems using other existing OCDMA codes. In particular, the spectral efficiency was calculated to be 1.0370 when TMWC of weight 3 was employed. The BER and eye pattern for the designed TMWC were also successfully obtained using OptiSystem simulation software. The results indicate that the proposed code design is promising for enhancing network capacity.

  19. Computationally Efficient Robust Color Image Watermarking Using Fast Walsh Hadamard Transform

    Directory of Open Access Journals (Sweden)

    Suja Kalarikkal Pullayikodi

    2017-10-01

    Full Text Available Watermark is the copy deterrence mechanism used in the multimedia signal that is to be protected from hacking and piracy such a way that it can later be extracted from the watermarked signal by the decoder. Watermarking can be used in various applications such as authentication, video indexing, copyright protection and access control. In this paper a new CDMA (Code Division Multiple Access based robust watermarking algorithm using customized 8 × 8 Walsh Hadamard Transform, is proposed for the color images and detailed performance and robustness analysis have been performed. The paper studies in detail the effect of spreading code length, number of spreading codes and type of spreading codes on the performance of the watermarking system. Compared to the existing techniques the proposed scheme is computationally more efficient and consumes much less time for execution. Furthermore, the proposed scheme is robust and survives most of the common signal processing and geometric attacks.

  20. Biographical Sketch: Baron Joseph Lister, FRCS, 1827–1912

    OpenAIRE

    Brand, Richard A.

    2010-01-01

    This biographical sketch on Baron Joseph Lister corresponds to the historic text, The Classic: On the Antiseptic Principle in the Practice of Surgery (1867), available at DOI 10.1007/s11999-010-1320-x.

  1. Biographical Sketch: Baron Joseph Lister, FRCS, 1827-1912.

    Science.gov (United States)

    Brand, Richard A

    2010-08-01

    This biographical sketch on Baron Joseph Lister corresponds to the historic text, The Classic: On the Antiseptic Principle in the Practice of Surgery (1867), available at DOI 10.1007/s11999-010-1320-x .

  2. Joseph Rotblat: influences, scientific achievements and legacy

    Science.gov (United States)

    Underwood, Martin

    2008-11-01

    Joseph Rotblat was one of the most distinguished nuclear physicists and peace campaigners of the post Second World War period. His peace activities rank alongside those of Albert Einstein and Bertrand Russell; he won the Nobel Peace Prize, jointly with the Pugwash movement, that he helped found. However, he made significant contributions to science, and in particular to the medical applications of accelerators, radiation and radio-nuclides. In this article his early work and influences in Poland are described. He then joined James Chadwick at Liverpool University and began work on the cyclotron recently constructed there. Rotblat then, together with Chadwick, joined the Manhattan Project. This experience was to shape his life. He stayed at Los Alamos for less than a year before walking out. He was suspected of being a spy. Rotblat then became Professor of Physics at St Bartholomew's Medical College and pioneered the use of a 15 MeV linear accelerator in treatment and research. He made fundamental contributions to understanding the effects of the fallout from nuclear bomb tests. He also, together with Patricia Lindop, made important contributions to understanding the biological effects of radiation.

  3. Joseph Leidy between two paradigms of Paleontology

    Directory of Open Access Journals (Sweden)

    Felipe Faria

    2012-08-01

    Full Text Available With the acceptance of the methods and research program developed by Georges Cuvier for the study of fossils, Paleontology had its first Kuhnian paradigm installed. Joseph Leidy began his works under this theoretical and methodological advice and practiced, within the scope of Paleontology, what Thomas Kuhn called normal science. However, with the accumulation of data from his taxonomic works, Leidy identified some issues that could not be answered in light of the cuvierian paradigm. Only the new paradigm, the evolutionism, could answer them, and thus Leidy joined the evolutionary theories of Charles Darwin. This transition process of a naturalist trained under one guidance, and that starts working under a new, is analyzed in this paper, taking into account the peculiarities of application of the framework provided by Kuhn, in a discipline such as Paleontology. Unlike the epistemological rupture predicted by Kuhn, in the paradigm shift in Paleontology many paleontologists have continued to work guided by the old paradigm, but producing usable data by evolutionists. Leidy was one of them, but his transition went further. From 1859, gradually, he began to use relationships of ancestry and natural selection as explanations for the morphological similarities between species that have taken place along the history of life.

  4. Joseph de Maistre and Retributionist Theology

    Directory of Open Access Journals (Sweden)

    Gabriel Andrade

    2017-12-01

    Full Text Available Joseph de Maistre is usually portrayed as Edmund Burke’s French counterpart, as they both wrote important treatises against the French Revolution. Although Maistre did share many of Burke’s conservative political views, he was much more than a political thinker. He was above all a religious thinker who interpreted political events through the prism of a particular retributionist theology. According to this theology, God punishes evil deeds, not only in the afterlife, but also in this terrestrial life; and sometimes, he may even use human tyrants as instruments of his wrath. This interpretation especially evident in Maistre’s Considerations sur la France, an early work in his philosophical career. In that book, Maistre interprets the French Revolution as divine punishment, and in that regard, his views bear some similarities to the Deuteronomist historian in the Hebrew Bible, who interpreted the destruction of Jerusalem and the Babylonian Exile, as divine punishment in retribution of Israel’s sins.

  5. Pioneers in infection control-Joseph Lister.

    Science.gov (United States)

    Newsom, S W B

    2003-12-01

    Joseph Lister is one of the pioneers of Infection Control. Not only did he reduce the incidence of wound infection (usually fatal pre-Lister) by the introduction of antiseptic surgery using carbolic acid, but also he was the first to apply Pasteur's principles to humans. He showed that urine could be kept sterile after boiling in swan-necked flasks. He was the first person to isolate bacteria in pure culture (Bacillus lactis) using liquid cultures containing either Pasteur's solution of turnip infusion and a special syringe to dilute the inoculum and so can be considered a co-founder of medical microbiology with Koch, who later isolated bacteria on solid media. Lister also pioneered the use of catgut and rubber tubing for wound drainage. His life can be split into five periods: 1844-1853, London: first period; 1853-1860, Edinburgh: first period; 1860-1869, Glasgow (where he developed his 'antiseptic system'); 1869-1877, Edinburgh: second period; 1877-1900, London: second period.

  6. Joseph Henry's Conception of Scientific Knowledge

    Science.gov (United States)

    Theerman, Paul

    1997-04-01

    Joseph Henry, America's premier physicist and physics teacher in the mid-nineteenth century, had decided views of scientific knowledge. These were expressed in two ways. First of all, scientific knowledge led to moral betterment. Thus the study of science was a morally good thing. This was not only because it led to the contemplation of God's creation, which was a standard reason justifying the study of science dating from the Scientific Revolution and even earlier. More importantly, the study of science itself was a moral discipline, imparting to scientists the habits and virtues of truthfulness, respect for others, care and diligence, and the discernment of meaningful patterns from experience. The moral ideals of science were expressed most strongly in Henry's upholding the international "Republic of Science"; conversely, cheapening science was a sign of moral failure. Second, for Henry and his generation, science provided a path to sure truth, separate from falsehood of both the politics and the quackery that characterized mid-century public life. Henry promoted this in his championing of the Smithsonian Institution a scientific establishment, against the ideas of others who wanted to make it a literary establishment or a training school for teachers. For Henry, the Smithsonian's scientific reputation would be established by relying on careful peer review in its publications, and supporting established scientists to write authoritative popular works. The purpose of both these activities was to raise the profile of science in the United States and further establish science and the scientific method as a guide to public life.

  7. Association between Machado-Joseph disease and oxidative stress biomarkers.

    Science.gov (United States)

    Pacheco, Laura Segabinazzi; da Silveira, Aron Ferreira; Trott, Alexis; Houenou, Lucien J; Algarve, Thaís Doeler; Belló, Caroline; Lenz, Adriano Flesch; Mânica-Cattani, Maria Fernanda; da Cruz, Ivana Beatrice Mânica

    2013-10-09

    Spinocerebellar ataxia type 3, also called Machado-Joseph disease (MJD), is an hereditary autosomal dominant neurodegenerative disease that affects the cerebellum and its afferent and efferent connections. Since the mechanism by which mutant ataxin-3 eventually leads to neuronal death is poorly understood, additional investigations to clarify the biological alterations related to Machado-Joseph disease are necessary. Recent investigations suggest that oxidative stress may contribute significantly to Machado-Joseph disease. We compared markers of oxidative stress between Machado-Joseph disease and healthy control subjects. The results showed that Machado-Joseph patients have higher catalase levels and lower thiol protein levels compared to control subjects. The peripheral blood lymphocyes of MJD patients also showed higher levels of DNA damage by the comet assay than control subjects. Our results corroborate the hypothesis that the oxidative stress is associated with MJD patients. However, whether strategies to increase cellular antioxidative capacity may be effective therapies for the treatment of Machado-Joseph disease is an open question. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Joseph Leidy entre dois paradigmas da Paleontologia

    Directory of Open Access Journals (Sweden)

    Felipe Faria

    Full Text Available Com a aceitação dos métodos e programas de pesquisa desenvolvidos por Georges Cuvier para o estudo dos fósseis, a Paleontologia teve seu primeiro paradigma kuhniano instalado. Joseph Leidy iniciou seus trabalhos sob esta orientação teórica e metodológica e praticou, no âmbito da Paleontologia, o que Thomas Kuhn denominou de ciência normal. Entretanto, com o acúmulo de dados provenientes de seus trabalhos taxonômicos, Leidy identificou algumas questões que não podiam ser respondidas sob a luz do paradigma cuvieriano. Somente o novo paradigma, o evolutivo, podia respondê-las e, desta forma, Leidy aderiu às teorias evolucionistas de Charles Darwin. Este processo de transição de um naturalista treinado sob uma orientação, e que passa a trabalhar sob uma nova, é analisado neste trabalho, levando-se em consideração as peculiaridades da aplicação da estrutura prevista por Kuhn em uma disciplina como a Paleontologia. Diferentemente do rompimento epistemológico previsto por Kuhn, na mudança de paradigma na Paleontologia, diversos paleontólogos continuaram a trabalhar orientados pelo velho paradigma, mas produzindo dados utilizáveis pelos evolucionistas. Leidy foi um deles, porém sua transição foi mais adiante, pois, a partir de 1859, gradualmente, ele começou a utilizar relações de ancestralidade e a seleção natural como explicações para as semelhanças morfológicas existentes entre as espécies que se sucederam ao longo da história da vida.

  9. Obituary: Richard Joseph Elston, 1960-2004

    Science.gov (United States)

    Jannuzi, Buell Tomasson; Bechtold, Jill

    2004-12-01

    Richard Joseph Elston, known for his development of innovative astronomical instrumentation, died on 26 January 2004 in Gainesville, Florida, after a four-year battle with Hodgkin's lymphoma. A professor of astronomy at the University of Florida, Richard had an unusually broad range of interests and skills, and a willingness to share his passion for astronomy with others, which made him a highly valued member of the astronomical community. Born 1 July 1960, in Albuquerque, New Mexico, Richard was the son of a geologist father and journalist mother. His childhood interest in astronomy and instrumentation matured as he majored in physics and astronomy at the University of New Mexico (BS, 1983) under the mentorship of Michael Zeilik. Richard pursued his PhD in astronomy at the University of Arizona and earned his degree in 1988. He pioneered the use of IR arrays for deep imaging surveys of the sky to study galaxy formation, and completed his thesis Search for Rapidly Forming Galaxies at High Redshift under the direction of George Rieke. Richard's graduate work included the first detection of galaxies at intermediate redshifts with evolved populations too red to have been identifiable from optical imaging surveys alone. In the Astrophysical Journal Letters in 1988, he, George Rieke, and Marcia Rieke reported the discovery of this new class of galaxies, now known as EROs (Extremely Red Objects), important as the possible progenitors of present day elliptical galaxies. Following post-doctoral positions at Kitt Peak National Observatory from 1988 to 1991 and at the Observatories of the Carnegie Institution of Washington from 1991 to 1992, Richard joined the scientific staff of Cerro Tololo Inter-American Observatory in Chile, part of the NSF's National Optical Astronomy Observatory. By 1994, he had become head of CTIO's IR instrumentation program and was leading the development of new instruments for the US astronomical community. In 1996, Richard married astronomer

  10. Walsh-Hadamard-Based 3-D Steganography for Protecting Sensitive Information in Point-of-Care.

    Science.gov (United States)

    Abuadbba, Alsharif; Khalil, Ibrahim

    2017-09-01

    Remote points-of-care has recently had a lot of attention for their advantages such as saving lives and cost reduction. The transmitted streams usually contain 1) normal biomedical signals (e.g., electrocardiograms) and 2) highly private information (e.g., patient identity). Despite the obvious advantages, the primary concerns are privacy and authenticity of the transferred data. Therefore, this paper introduces a novel steganographic mechanism that ensures 1) strong privacy preservation of private information by random concealing inside the transferred signals employing a key and 2) evidence of originality for the biomedical signals. To maximize hiding, fast Walsh-Hadamard transform is utilized to transform the signals into a group of coefficients. To ensure the lowest distortion, only less-significant values of coefficients are employed. To strengthen security, the key is utilized in a three-dimensional (3-D) random coefficients' reform to produce a 3-D order employed in the concealing process. The resultant distortion has been thoroughly measured in all stages. After extensive experiments on three types of signals, it has been proved that the algorithm has a little impact on the genuine signals ( 1 %). The security evaluation also confirms that unlawful retrieval of the hidden information within rational time is mightily improbable.

  11. Reflection on the Theology of Joseph Ratzinger (Pope Benedict XVI ...

    African Journals Online (AJOL)

    This essay looks at ways in which the theology of Joseph Ratzinger, now Pope Benedict XVI, shows affinities with Reformation theological thought. Following a brief look at the background to my own interest in Ratzinger, I present some important features of his theology, shedding light on it particularly through drawing ...

  12. Alternanter dentata (Joseph's coat) leaf meal as replacement for ...

    African Journals Online (AJOL)

    Alternanter dentata (Joseph's coat) leaf meal as replacement for maize on the performance of broiler finisher chicks. ... Journal of Agriculture and Food Sciences ... A 28- day feeding trial was conducted using 225 unsexed Marshal strain of broiler finisher chicks fed 0, 10, 20, 30 and 45% Alternanter dentata Leaf Meal ...

  13. Perils of Accommodation: The Case of Joseph W. Holley

    Science.gov (United States)

    O'Brien, Thomas V.

    2007-01-01

    This study examines accommodationism, a tactic of racial uplift used by black school founders and teachers in the Jim Crow South. For founders, accommodationism was a dangerous process of collaboration, resistance, and compromise. The subject under study is Joseph Winthrop Holley. Born in South Carolina, Holley studied in the North at Phillips…

  14. Franz Joseph Gall and music: The faculty and the bump

    NARCIS (Netherlands)

    Eling, P.A.T.M.; Finger, S.; Whitaker, H.A.

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can

  15. Joseph Lancaster and the History of Reading Instruction.

    Science.gov (United States)

    Ediger, Marlow

    Examining the origin and accomplishments of the Lancastrian monitorial system of instruction, this paper discusses the influence of that system on American education. It gives a brief history of how Joseph Lancaster became involved in reading instruction and how he was a pioneer in emphasizing a reading curriculum that was written down. It then…

  16. Joseph Lister and his 1876 tour of America.

    Science.gov (United States)

    Rutkow, Ira

    2013-06-01

    To explore the events and people that shaped Joseph Lister's 1876 tour of America and how the journey became a landmark episode in the history of surgery. In a little known chapter in American medical history, Joseph Lister toured the United States in 1876 in an attempt to convince physicians that they should accept his ideas about surgical antisepsis. His 2 month-long visit, which included a transcontinental railroad trip across the North American continent, sparked controversy as doctors struggled to understand the relationship between bacteria and disease. An analysis of the published medical and lay literature and unpublished documents pertaining to Lister and antisepsis for the 15-year period, from 1865 to 1880. Joseph Lister's 1876 tour of America proved a turning point in the slow process of accepting the principles of antisepsis by the nation's doctors. This visit laid the foundation for the blossoming of medical care in America and the remarkable advances that followed. Among the most debated topics in the American medical world of 1876 was whether to accept Joseph Lister's principles of surgical antisepsis. He was invited to address the issue and gave a series of lectures in Philadelphia, Boston, and New York. The presentations marked the beginning of a significant change in American physicians' awareness of the correlation between wounds, germs, and pus. Lister's visit is a crucial milestone in the history of medicine.

  17. The role of Joseph Lister in developing the absorbable ligature.

    Science.gov (United States)

    Hall, M J

    2001-08-01

    Joseph Lister is associated with pioneering work on antisepsis. However an important but less well-known contribution to surgical progress was his work on the absorbable suture. This article details the problems Lister faced in operative surgery, his observations and experiments that lead to his development of an absorbable suture.

  18. Book Review Language and politics By John E Joseph (2006 ...

    African Journals Online (AJOL)

    Open Access DOWNLOAD FULL TEXT Subscription or Fee Access. Book Review Language and politics. By John E Joseph (2006). Desmond Painter. Abstract. Edinburgh University Press, Edinburgh Hardback ISBN 9780748624539 170 pages. Southern African Linguistics and Applied Language Studies 2008, 26(2): 295– ...

  19. Science and Worldviews in the Classroom: Joseph Priestley and Photosynthesis

    Science.gov (United States)

    Matthews, Michael R.

    2009-01-01

    This paper elaborates on the life and publications of Joseph Priestley, the eighteenth-century polymath. The paper outlines his particular place in the European Enlightenment; it stresses the importance of philosophy and worldview in his scientific work on pneumatic chemistry, the composition of air, and his discovery of the process of…

  20. Using Joseph Campbell to Improve Students' Response to Literature.

    Science.gov (United States)

    Barnum, Carol M.

    1992-01-01

    Shows how teachers can use the videotapes and writings of Joseph Campbell to help students see patterns in literature and respond personally to it. Presents Campbell's explanation of the monomyth of the hero's journey, and discusses three works in which the pattern is present. (SR)

  1. 33 CFR 117.651 - St. Joseph River.

    Science.gov (United States)

    2010-07-01

    ... US33 (Blossomland) bridge, mile 0.9, and the BL-94 (Bicentennial) bridge, mile 1.3, both at St. Joseph...-quarter hour. (c) From December 16 through the last day of February, the draw of both bridges shall open...

  2. The lssue of Guilt in Oedipus and Joseph K.

    Directory of Open Access Journals (Sweden)

    Janez Vrečko

    2002-07-01

    Full Text Available This essay addresses hamartia in Oedipus and Joseph K., originally guilt without sin later turned in to guilt of sin, as well as freedom and fate, death and redemption. The tragedy Oedipus the King starts with the plague in Thebes, while The Trial starts with the arrest of Joseph K., both events leading to the source of »misfortune«; since the source of misfortune is external, the two protagonists are guilty without committing a crime. In both works Aristotle's concept of hamartia is understood as an objective »tragic flaw« as well as a subjective decision taken by the hero. Since »guiltiness invites judgment«, both Oedipus and Joseph K. choose to flee in a »Wrong direction«, which leads to the fulfilment of the prophecy and to a verdict respectively. They misunderstand the objective hamartia and transform their guilt without sin in to the guilt of sin. But Oedipus' uncovering of his own past once the prophecy is fulfilled leads him to a theophanic death, while Joseph's recognition that his life has come to ruin leads to a bestial death. Iocasta and several female characters in The Trial attempt to thrust both men back in to the arena of objective hamartia, to restore them to the state of guilt without crime, but they fail. They do succeed, however, in leading the heroes to anagnorisis. This recognition enables Oedipus to evince his sense of responsibility by carrying out his self-punishment. Joseph's recognition, by contrast, includes neither responsibility nor self-punishment. The scene with Titorelli shows that Joseph's trial can only take place between two extremes -justice and manhunt - and as such it has parallels with the Chorus song following the scene with Oedipus and Teiresias. Moreover, it has a connection with the chapter taking place in the Cathedral, since the protagonists of each scene are identified at this point and their destinies linked to their names. On another level this scene reveals a similarity between the Sphinx

  3. Obituary: Joseph Wyan Chamberlain, 1928-2004

    Science.gov (United States)

    Hunten, Donald M.

    2004-12-01

    Joseph W. Chamberlain died at home with his family on April 14 2004 after a long illness. He was born August 24, 1928 and raised in Boonville, Missouri, where his father was the doctor. There was no doubt that both Joe and his elder brother Gilbert would also become doctors, but Joe's first class in comparative anatomy at the University of Missouri convinced him that this was not his destiny and he immediately switched to physics and astronomy. He obtained a Masters degree in physics and moved on to the University of Michigan; his advisor was Lawrence Aller and he was also strongly influenced by Leo Goldberg. Early in 1952 he was awarded a PhD and began work at the Air Force Cambridge Research Center where he changed his interests to the upper atmosphere. Among his duties was liaison with research groups at several universities, and I met him when he visited us at the University of Saskatchewan one very cold winter day. He was soon posted to work with Aden Meinel at Yerkes Observatory, where he was added to the faculty and became the leader of the group when Meinel departed to organize the Kitt Peak National Observatory. He himself moved there in 1962 as Associate Director for Space Science; the name of the division was later changed to Planetary Science. He recruited a strong group to work on planetary atmospheres and several group members played important roles in the Mariner 10, Pioneer Venus, Viking, Voyager and Galileo missions. He was elected to the National Academy of Sciences in 1965. As leader of the group he recruited at Kitt Peak, Joe earned the admiration and loyalty of us all. He strongly preferred doing science to his administrative tasks, but he was still effective at the latter. He was considerably bothered that his superiors, especially the managing boards with which he had to deal, did not always meet his high standards. Joe's friends and colleagues felt, and still feel, that he would have been much happier as a member of a teaching faculty, and

  4. Science, alchemy and light: paintings by Joseph Wright of Derby.

    Science.gov (United States)

    Dominiczak, Marek H

    2002-01-01

    This article considers two paintings by the English painter, Joseph Wright of Derby (1734-97), 'An Experiment on a Bird in the Air Pump' and 'The Alchemist in Search of the Philosopher's Stone' as painterly reflections on the early industrial culture. Particularly interesting in the "Experiment on a Bird" is the broad spectrum of spectator's reactions to the experiment; this can be related to the contemporary debate on the contextualization of science.

  5. reflection on the theology of joseph ratzinger (pope benedict xvi)

    African Journals Online (AJOL)

    Reflection on the theology of Joseph Ratzinger. 24. (Ratzinger 1995:48). In him, the second, the definitive Adam (1 Cor. 15: 44-48; Col. 1: 15), we are shown what it really is to be human; and we see that, with creation – the first Adam – a preliminary sketch, a rough draft, was given, which means that we are beings en route,.

  6. Kepentingan Rusia Dalam Memberikan Suaka Politik Kepada Edward Joseph Snowden

    OpenAIRE

    ", Ibrahim; Iskandar, Irwan

    2017-01-01

    This research to explain interest of Russia with Snowden. Edward Joseph Snowden is a former Central Intelligence Agency (CIA) employee and a former contractor for National Security Agency (NSA) who leaked classified information to The Guardian and The Washington Post. Snowden who leaked classified information have Surveillance program doing by United State of America. The Surveillance Program is a cooperate between 9 big companies from United States, which: Yahoo!, Facebook, Google, Apple, Sk...

  7. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Science.gov (United States)

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  8. Astronaut Joseph Kerwin takes blood sample from Astronaut Charles Conrad

    Science.gov (United States)

    1973-01-01

    Scientist-Astronaut Joseph P. Kerwin (right), Skylab 2 science pilot and a doctor of medicine, takes a blood sample from Astronaut Charles Conrad Jr., Sylab 2 commander, as seen in this reproduction taken from a color television transmission made by a TV camera aboard the Skylab 1 and 2 space station cluster in Earth orbit. The blood sampling was part of the Skylab Hematology and Immunology Experiment M110 series.

  9. A Political Approach of the Popular Credit: Pierre-Joseph Proudhon and the mutual credit

    OpenAIRE

    Cyrille Ferraton; David Vallat

    2011-01-01

    Pierre-Joseph Proudhon’s ideas on credit and money have been considered to be not very relevant and above all unrealistic. However, they have known an uncommon posterity. They influenced Silvio Gesell who is John Maynard Keynes’s reference. This article analyses Pierre-Joseph Proudhon’s exchange bank plan. We show that Pierre- Joseph Proudhon’s ideas on credit and money are opened to criticism but require a reexamination because we can draw many lessons from them.

  10. Automatic lithofacies segmentation from well-logs data. A comparative study between the Self-Organizing Map (SOM) and Walsh transform

    Science.gov (United States)

    Aliouane, Leila; Ouadfeul, Sid-Ali; Rabhi, Abdessalem; Rouina, Fouzi; Benaissa, Zahia; Boudella, Amar

    2013-04-01

    The main goal of this work is to realize a comparison between two lithofacies segmentation techniques of reservoir interval. The first one is based on the Kohonen's Self-Organizing Map neural network machine. The second technique is based on the Walsh transform decomposition. Application to real well-logs data of two boreholes located in the Algerian Sahara shows that the Self-organizing map is able to provide more lithological details that the obtained lithofacies model given by the Walsh decomposition. Keywords: Comparison, Lithofacies, SOM, Walsh References: 1)Aliouane, L., Ouadfeul, S., Boudella, A., 2011, Fractal analysis based on the continuous wavelet transform and lithofacies classification from well-logs data using the self-organizing map neural network, Arabian Journal of geosciences, doi: 10.1007/s12517-011-0459-4 2) Aliouane, L., Ouadfeul, S., Djarfour, N., Boudella, A., 2012, Petrophysical Parameters Estimation from Well-Logs Data Using Multilayer Perceptron and Radial Basis Function Neural Networks, Lecture Notes in Computer Science Volume 7667, 2012, pp 730-736, doi : 10.1007/978-3-642-34500-5_86 3)Ouadfeul, S. and Aliouane., L., 2011, Multifractal analysis revisited by the continuous wavelet transform applied in lithofacies segmentation from well-logs data, International journal of applied physics and mathematics, Vol01 N01. 4) Ouadfeul, S., Aliouane, L., 2012, Lithofacies Classification Using the Multilayer Perceptron and the Self-organizing Neural Networks, Lecture Notes in Computer Science Volume 7667, 2012, pp 737-744, doi : 10.1007/978-3-642-34500-5_87 5) Weisstein, Eric W. "Fast Walsh Transform." From MathWorld--A Wolfram Web Resource. http://mathworld.wolfram.com/FastWalshTransform.html

  11. Complementary Walsh-Hadamard coded optical CDMA coder/decoders structured over arrayed-waveguide grating routers

    Science.gov (United States)

    Huang, Jen-Fa; Yang, Chao-Chin; Tseng, Shin-Pin

    2004-01-01

    In this paper, an optical code-division multiple-access (OCDMA) system with complementary Walsh-Hadamard coded optical encoder/decoder configuration structured over arrayed-waveguide grating (AWG) routers is examined. In the proposed system, each network user requires only two AWG routers to accomplish spectral encoding and decoding for complementary keying, thus, resulting a simpler and low cost system. Performance of the proposed system is analyzed by taking the effect of phase-induced intensity noise into account. The result indicates that the established system not only preserves the capability of suppressing multiple-access interference (MAI), but also improves bit-error-rate performance as compared to the conventional coders employing simple on-off keying.

  12. Kevin Walsh, The archaeology of mediterranean landscapes, human-environment interaction from the Neolithic to the Roman period

    OpenAIRE

    Morhange, Christophe

    2014-01-01

    Ce nouvel ouvrage fait la part belle aux travaux d’archéologie de l’environnement initiés en Provence il y a plus de 30 ans par l’historien-archéologue Philippe Leveau et la géomorphologue Mireille Provansal. Kevin Walsh, par ses liens scientifiques étroits avec l’université d’Aix, permet de faire rayonner de nombreux travaux originellement rédigés en langue française et restés souvent un peu confidentiels dans le monde anglo-saxon. Il s’agit là d’une très belle synthèse bien illustrée et arg...

  13. Researcher Profile: An Interview with Joseph Goetz, Ph.D.

    Directory of Open Access Journals (Sweden)

    2010-10-01

    Full Text Available Dr. Joseph Goetz is an internationally known researcher working in academia to blend financial planning, financial counseling, and therapy approaches into tools and techniques that enhance the well-being of individuals and families. Dr. Goetz’s work in developing the ASPIRE clinic at the University of Georgia has helped place Georgia at the forefront of financial therapy research. In this interview readers of the Journal can learn more about the exciting work Dr. Goetz is doing to advance the Financial Therapy profession.

  14. Joseph O’Connor. Star of the Sea

    Directory of Open Access Journals (Sweden)

    Alexandra POULAIN

    2007-10-01

    Full Text Available It has become a commonplace to note that although the Irish Famine was a major cataclysm, and one which contributed to the complete reshaping of Ireland in the late nineteenth-century, it has not often found its way into Irish literature – arguably because it was simply too traumatic for representation: as Terry Eagleton puts it, “the events strains at the limits of the inarticulable.” In Star of the Sea, however, the young Irish novelist Joseph O’Connor not only vividly conjures up the memor...

  15. Kaiser Franz Joseph I und die Serben 1848–1908

    Directory of Open Access Journals (Sweden)

    Wolfgang Rohrbach

    2017-02-01

    Full Text Available A century from death of Emperor Franz Joseph I (+21.11.1916 triggered a great number of publications about life and almost seven decades long reign of a popular monarch. As the political struggle between Russia, Prussia, Italy and Ottoman Empire are depicted with moderation, Serbia is described unidimensional, with an emphasis on the last decade of Emperors rule. In order to remedy this shortcoming, this contribution is focusing on a period between 1848 and 1908. Today we know much more about relations between Franz Joseph and King Milan Obrenović, as well as with dignitaries of Serbian Orthodox Church, and military, academic and artistic elite. It is, therefore, possible to refute entrenched notions about constant enmity and hostility between Austria and Serbia. In this work, an emphasis is put on cooperation between Austria and Serbia from 1848, when Serbs at Emperors request held a number of important political and military positions, whereas Serbian artists took part in the reconstruction of Imperial Vienna. The university of Vienna hosted the oldest institute for slavistic (1849, becoming, therefore, a crossroad of the cultural and social development of the Balkans.

  16. Carl Sagan and Joseph Shklovsky: Intelligent Life in the Universe

    Science.gov (United States)

    Kurt, Vladimir

    J. S. Shklovsky and Carl Sagan played an outstanding role in modern astronomy. Their names are well known not only to professional astronomers, but also to millions of educated people in many countries, which are interested in modern state of science research. Among these trends of modern science, which are difficult to define, are such problems, as the creation of Solar system, the origin of life on Earth, the evolution of living organisms on Earth from the simplest viruses to Homo Sapiens, the evolution of intelligence and technology. Finally, both outstanding scientists were deeply interested in the problem of SETI (Search Extraterrestrial Intelligence), i.e. search of extraterrestrial civilizations and methods of making contacts with them. And both scientists were high professionals in their fields. Joseph Shklovsky was a theoretical astronomer in all fields of modern astronomy (geophysics and physics of the upper atmosphere of the Earth, Sun and Solar Corona, Interplanetary Medium and Solar Wind, Interstellar Medium, Supernova and their remnants, the Galaxy and galaxies, Quasars and Cosmology). There is hardly a field in modern astrophysics (except perhaps the theory of the interior structure of stars), where Joseph Shklovsky has not l a bright stamp of his talent…

  17. Joseph Campbell, Jung, Anne Tyler, and "The Cards": The Spiritual Journey in "Searching for Caleb."

    Science.gov (United States)

    Thomson, Karen M.

    Joseph Campbell, Carl Jung, and Anne Tyler have all dealt with spiritual journeys and card reading in their writings. In his book "Tarot Revelations," Joseph Campbell discusses his first association with tarot cards, dating from 1943, when he was introduced to the symoblism of playing cards by his friend and mentor, Heinrich Zimmer. Carl…

  18. Die treibenden Kräfte in modernen Volkswirtschaften: zum 50. Todestag von Joseph Alois Schumpeter

    OpenAIRE

    Hanusch, Horst

    2000-01-01

    50 Jahre nach Joseph A. Schumpeters Tod am 8. Januar 1950 ist sein wissenschaftliches Werk noch immer von aktueller Relevanz. Professor Horst Hanusch, Generalsekretär der Internationalen Joseph A. Schumpeter Gesellschaft, würdigt das Werk des bedeutenden Ökonomen.

  19. Joseph Roth, tradutor do Império perdido

    Directory of Open Access Journals (Sweden)

    Luis S. Krausz

    2015-06-01

    Full Text Available Este artigo discute um folhetim jornalístico do escritor austríaco Joseph Roth que trata de uma miniatura do Templo de Salomão, encontrada por ele num café da Hirtenstrasse berlinense, no coração do que foi, na década de 1920, o bairro habitado pelos judeus do Leste da Europa na capital alemã. A nostalgia, sob cujo signo foi criada tal miniatura, torna-se uma metáfora da nostalgia pelo império Austro-Húngaro, chave para a compreensão da obra romanesca deste escritor. Ao mesmo tempo, esta nostalgia rothiana é contextualizada no âmbito das crenças místicas e messiânicas do judaísmo tradicional.

  20. Joseph Rotblat: Moral Dilemmas and the Manhattan Project

    Science.gov (United States)

    Veys, Lucy

    2013-12-01

    John Fitzgerald Kennedy famously said, "One man can make a difference and every man should try."1 Joseph Rotblat (1908-2005) was the quintessence of Kennedy's conviction. He was the only scientist who left Los Alamos after it transpired that the atomic bomb being developed there was intended for use against adversaries other than Nazi Germany. I explore Rotblat's early research in Warsaw and Liverpool, which established his reputation as a highly capable experimental physicist, and which led him to join the Manhattan Project at Los Alamos in 1944. I examine his motivation for resigning from the project in 1945, and the unwillingness of his fellow scientists to follow suit, which draws attention to the continuing discourse on the responsibility of scientists for the consequences of their research.

  1. From Exile to Affirmation: The Poetry of Joseph Brodsky

    Directory of Open Access Journals (Sweden)

    David Patterson

    1993-06-01

    Full Text Available This article examines the relation between the exile of the poet from his homeland and the "exile of the word." The notion of the exile of the word pertains to the poet's problem of re-introducing meaning to the word—an excess of meaning that conveys more than the word can normally convey—through his poetry. Showing how the poet in exile becomes a poet of exile, the article examines what poetry has to do with a larger difficulty of exile and homelessness in human life. Brodsky's poetry, the article argues, addresses this very difficulty. The article concludes that the human capacity to dwell in the world is a capacity to instill the word with meaning, and that this is one important message to come to us through the poetry of Joseph Brodsky.

  2. Joseph Lister and the performance of antiseptic surgery.

    Science.gov (United States)

    Worboys, Michael

    2013-09-20

    This article highlights a neglected feature of Joseph Lister's work, namely how, in addition to promoting germ theories and the principles of the antiseptic system, he also devoted much time and effort to communicating the performative aspects of antisepsis and of the many other surgical innovations that he developed. Attention to 'detail' and striving for 'improvement' were crucial to Listerian practice, and he sought to convey his credo in three main ways: first, his publications aimed at 'bringing the subject out in the same sort of way as it had been worked out by himself'; second, he set out strict protocols and information on materials and methods, yet also encouraged surgeons to improvise; and third, he made himself an exemplar of a new form of professionalism, which made constancy and vigilance in practice a moral duty for surgeons.

  3. Joseph Conrad and the spontaneous combustion of coal - Part 1

    Energy Technology Data Exchange (ETDEWEB)

    Walters, A.D. [Kilborn Engineering Pacific Ltd., Vancouver, BC (Canada)

    1996-12-31

    Joseph Conrad`s novel `Youth` described an on-board fire and explosion from transported coal between Sumatra and Bangka Island. This incident is based on Conrad`s experience as a mariner transporting coal, and displays a detailed knowledge of the technical issues and preventative actions involved in the spontaneous combustion of coal cargoes at sea. The coal concerned was West Hartley coal, and in this article the author examines the combustion characteristics of this coal, and the historical information available on the explosion on board the `Palestine`. The reasons for spontaneous combustion are examined, with particular attention paid to oxidation, moisture content and pyrite oxidation. West Hartley coal was a high volatile bituminous coal, with high self-heating tendencies, and so likely to undergo spontaneous combustion in the right conditions. Self-heating in ships is now well researched as a result of the international maritime coal trade. 21 refs., 3 figs., 7 tabs.

  4. Constructing Joseph Fredericks: competing narratives of a child sex murderer.

    Science.gov (United States)

    Petrunik, Michael; Weisman, Richard

    2005-01-01

    Joseph Fredericks--one of Canada's most notorious sex offenders--was defined through the institutions that dealt with him from his infancy to his death to the inquest held after his death. In this paper, we locate in historical context and compare the different narratives that were constructed of his life in each of these institutional settings from unwanted child to 'mental defective' to psychiatric offender to criminal recidivist to victim to iconic sexual predator. We show that each of these narratives claimed to capture the essence of Fredericks in terms of what were his core characteristics and what remedies were necessary for the problems he posed only to be superseded by new narratives based on different assumptions. Finally, we show how one of these conceptions of Frederick's essence influenced a shift in Canadian public policy for sex offenders toward the greater emphasis on community protection characteristic of public policy in the United States.

  5. Constructing a two bands optical code-division multiple-access network of bipolar optical access codecs using Walsh-coded liquid crystal modulators

    Science.gov (United States)

    Yen, Chih-Ta; Huang, Jen-Fa; Chih, Ping-En

    2014-08-01

    We propose and experimentally demonstrated the two bands optical code-division multiple-access (OCDMA) network over bipolar Walsh-coded liquid-crystal modulators (LCMs) and driven by green light and red light lasers. Achieving system performance depends on the construction of a decoder that implements a true bipolar correlation using only unipolar signals and intensity detection for each band. We took advantage of the phase delay characteristics of LCMs to construct a prototype optical coder/decoder (codec). Matched and unmatched Walsh signature codes were evaluated to detect correlations among multiuser data in the access network. By using LCMs, a red and green laser light source was spectrally encoded and the summed light dots were complementary decoded. Favorable contrast on auto- and cross-correlations indicates that binary information symbols can be properly recovered using a balanced photodetector.

  6. Comments on the Poem “Architecture” by Joseph Brodsky

    Directory of Open Access Journals (Sweden)

    Konstantin Lidin

    2016-11-01

    Full Text Available The poem “Architecture” by Joseph Brodsky was commented on by Alexander Rappaport, Konstantin Lidin and Elena Bagina. The poem deserves to be studied at all architectural schools and to be learnt by heart by future architects; and the problems touched upon in this poem deserve to be thought about by architectural theorists. This poem is a quintessence of the contemporary theoretical thought about architecture. It raises such themes as time and memory, space, place and substance. It also speaks about ideal geometric shapes in architecture and dynamics of architectural forms. Architectural works are “a step beyond the drawing”, an unbreakable link of times. The domes of architectural masterpieces form a safety parachute of our civilization. Alexander Rappaport, Konstantin Lidin and Elena Bagina made a comment on each line of this short but remarkably concise, lofty and ironical work by Joseph Brodsky. These comments partially coincide and partially differ. You may either agree or argue with the authors’ opinion. But any meaningful talk about the place and the role of architecture and architectural profession in the present-day world is of importance. It is symptomatic that the modern architectural studies are focused on the history of architecture, being afraid (or unwilling due to a complex and controversial situation in today’s profession to deal with urgent and difficult problems. Wherever the architectural theory of the late 20th century looked for fertility drugs, be it in mathematics, semiotics, sociology, linguistics, it was in vain. In the early 21st century it came to the crossroads. It is no good to verify the death of architecture, because it would mean, according to Brodsky, the end of civilization. Let’s believe that architecture has its future and that it will remain “a thing of stone”, the strongest material on Earth.

  7. Highlighting High Performance: Adam Joseph Lewis Center for Environmental Studies, Oberlin College, Oberlin, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-11-01

    Oberlin College’s Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials

  8. Yue Joseph Wang named Grant A. Dove Professor of Electrical and Computer Engineering

    OpenAIRE

    Owczarski, Mark

    2009-01-01

    Yue Joseph Wang, professor of electrical and computer engineering in the College of Engineering at Virginia Tech, has been named the Grant A. Dove Professor of Electrical and Computer Engineering by the Virginia Tech Board of Visitors.

  9. “Migrant Women Are Always Added”: In Conversation with Ebun Joseph Akpoveta

    Directory of Open Access Journals (Sweden)

    Asier Altuna-García de Salazar

    2017-03-01

    Ebun Joseph Akpoveta lives in Dublin with her beloved family. I would like to thank her for her patience and kindness in collaborating to expand and finalise the present written version of her interview through e-mail.

  10. Reason, Science, Criticism. Joseph Agassi interviewed on his 90th birthday by Zuzana Parusniková

    Czech Academy of Sciences Publication Activity Database

    Parusniková, Zuzana; Agassi, J.

    2017-01-01

    Roč. 24, č. 4 (2017), s. 526-545 ISSN 1335-0668 Institutional support: RVO:67985955 Keywords : Joseph Agassi * interview Subject RIV: AA - Philosophy ; Religion http://klemens.sav.sk/fiusav/organon/?q=sk/reason- science -criticism

  11. Joseph and Michael Haydn in the Bohemian music archives. An anniversary tribute

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2012-01-01

    Roč. 20, č. 1 (2012), s. 117-126. ISBN 978-3-486-58949-8. ISSN 1865-5696 Institutional support: RVO:68378076 Keywords : Joseph Haydn * Michael Haydn * music archives Subject RIV: AL - Art, Architecture, Cultural Heritage

  12. Flattened facial colliculus on magnetic resonance imaging in Machado-Joseph disease.

    Science.gov (United States)

    Ogawa, Yoshitsugu; Ito, Shoichi; Makino, Takahiro; Kanai, Kazuaki; Arai, Kimihito; Kuwabara, Satoshi

    2012-07-01

    Atrophy of the pontine tegmentum and facial colliculus is a characteristic pathological feature of Machado-Joseph disease. We assessed whether this finding can be detected by conventional brain magnetic resonance imaging. A total of 17 patients with genetically confirmed Machado-Joseph disease, 15 disease controls (spinocerebellar ataxia type 6 and dentatorubral-pallidoluysian atrophy), and 17 normal subjects were examined using a 1.5-Tesla magnetic resonance imaging scanner. The widths of the facial colliculus, pontine tegmentum, and pontine base and the area of the fourth ventricle were measured on axial T2-weighted imaging. Pathological examination was performed in 9 Machado-Joseph disease patients. In addition, visual inspection of the facial colliculus was evaluated by receiver operating characteristic analysis. The width of the facial colliculus was significantly smaller in Machado-Joseph disease patients (0.37 ± 0.16 mm; mean ± standard deviation) than in normal subjects (0.73 ± 0.30 mm; P Machado-Joseph disease (4.85 ± 0.58 mm) and dentatorubral-pallidoluysian atrophy (4.72 ± 0.59) patients than in normal subjects (6.35 ± 0.74 mm; P Machado-Joseph disease from dentatorubral-pallidoluysian atrophy (0.78) and spinocerebellar ataxia type 6 (0.87). Pathological evaluation showed significant atrophy of the facial colliculus in all Machado-Joseph disease patients. Atrophy of the facial colliculus is a feasible magnetic resonance imaging finding for diagnosing Machado-Joseph disease, and it is easily found as a flattening of the fourth ventricular floor. Copyright © 2012 Movement Disorder Society.

  13. Joseph Rotblat a man of conscience in the nuclear age

    CERN Document Server

    Underwood, Martin

    2009-01-01

    Professor Sir Joseph Rotblat was a distinguished scientist who made a significant contribution to nuclear physics, worked on the development of the atomic bomb (he was the only person to leave the Manhattan Project), and was suspected of being a Soviet spy. After Hiroshima and Nagasaki he became a peace campaigner and dedicated himself to the medical uses of nuclear physics and radiation.He took up the post of Professor of Physics (as applied to medicine) at St. Bartholomew's Medical College and made major contributions to this field, becoming one of the world's leading researchers into the biological effects of radiation. … His life from the early 1950s until his death in August 2005 was devoted to the abolition of nuclear weapons and the promotion of world peace. His work ranked with that of Albert Einstein and Bertrand Russell. He helped found The Pugwash Conferences on Science and World Affairs, and together with Pugwash he was awarded the Nobel Peace Prize in 1995. Rotblat promoted dialogue between Sov...

  14. Strabismus and Micro-Opsoclonus in Machado-Joseph Disease.

    Science.gov (United States)

    Ghasia, Fatema F; Wilmot, George; Ahmed, Anwar; Shaikh, Aasef G

    2016-08-01

    We describe novel deficits of gaze holding and ocular alignment in patients with spinocerebellar ataxia type 3, also known as Machado-Joseph disease (MJD). Twelve MJD patients were studied. Clinical assessments and quantitative ocular alignment measures were performed. Eye movements were quantitatively assessed with corneal curvature tracker and video-oculography. Strabismus was seen in ten MJD patients. Four patients had mild to moderate intermittent exotropia, three had esotropia, one had skew deviation, one had hypotropia, and one patient had moderate exophoria. Three strabismic patients had V-pattern. Near point of convergence was normal in two out of three patients with exotropia. Gaze holding deficits were also common. Eight patients had gaze-evoked nystagmus, and five had micro-opsoclonus. Other ocular motor deficits included saccadic dysmetria in eight patients, whereas all had saccadic interruption of smooth pursuit. Strabismus and micro-opsoclonus are common in MJD. Coexisting ophthalmoplegia or vergence abnormalities in our patients with exotropia that comprised 50 % of the cohort could not explain the type of strabismus in our patients. Therefore, it is possible that involvement of the brainstem, the deep cerebellar nuclei, and the superior cerebellar peduncle are the physiological basis for exotropia in these patients. Micro-opsoclonus was also common in MJD. Brainstem and deep cerebellar nuclei lesion also explains micro-opsoclonus, whereas brainstem deficits can describe slow saccades seen in our patients with MJD.

  15. Franz Joseph Gall and music: the faculty and the bump.

    Science.gov (United States)

    Eling, Paul; Finger, Stanley; Whitaker, Harry

    2015-01-01

    The traditional story maintains that Franz Joseph Gall's (1758-1828) scientific program began with his observations of schoolmates with bulging eyes and good verbal memories. But his search to understand human nature, in particular individual differences in capacities, passions, and tendencies, can also be traced to other important observations, one being of a young girl with an exceptional talent for music. Rejecting contemporary notions of cognition, Gall concluded that behavior results from the interaction of a limited set of basic faculties, each with its own processes for perception and memory, each with its own territory in both cerebral or cerebellar cortices. Gall identified 27 faculties, one being the sense of tone relations or music. The description of the latter is identical in both his Anatomie et Physiologie and Sur les Fonctions du Cerveau et sur Celles de Chacune de ses Parties, where he provided positive and negative evidences and discussed findings from humans and lower animals, for the faculty. The localization of the cortical faculty for talented musicians, he explained, is demonstrated by a "bump" on each side of the skull just above the angle of the eye; hence, the lower forehead of musicians is broader or squarer than in other individuals. Additionally, differences between singing and nonsinging birds also correlate with cranial features. Gall even brought age, racial, and national differences into the picture. What he wrote about music reveals much about his science and creative thinking. © 2015 Elsevier B.V. All rights reserved.

  16. Joseph Carpue's file drawer experiment - A murder mystery from 1801.

    Science.gov (United States)

    Freshwater, M Felix

    2015-12-01

    Today unpublished or "file drawer" experiments are the impetus for trial registration and reporting of all results. In 1801, Joseph Carpue, the father of modern plastic surgery, did a file drawer experiment for Benjamin West, who was President of the Royal Academy of Arts. George III had commissioned West to create the largest stained glass window ever created whose theme, the Crucifixion, was based upon Michelangelo's drawing. Subsequently, West suffered a series of political, professional and economic setbacks. In the summer of 1801, West's project was delayed. By the fall, West hoped that independent scientific confirmation of his design could salvage the project. West approached Carpue who obtained a murderer's fresh corpse that he crucified and documented the results with plaster casts created by sculptor Thomas Banks. Carpue's experiment showed that West's window design wrongly depicted the Crucifixion because West had posed the hands and shoulders incorrectly. West died in 1820 without ever being associated with Carpue's experiment. Carpue's obituary in The Lancet in 1846 contained Carpue's handwritten note that described the experiment but not West's Royal commission. As no records or publications associate the cast with West project, this can be considered to be a file drawer experiment. After 1801, West made further drawings of the Crucifixion that showed the figures in the same position as the cast. Nineteenth century auction catalogues suggest that West made a corrected Crucifixion painting, but its current location remains a mystery.

  17. Moths on the Flatbed Scanner: The Art of Joseph Scheer.

    Science.gov (United States)

    Buchmann, Stephen L

    2011-12-14

    During the past decade a few artists and even fewer entomologists discovered flatbed scanning technology, using extreme resolution graphical arts scanners for acquiring high magnification digital images of plants, animals and inanimate objects. They are not just for trip receipts anymore. The special attributes of certain scanners, to image thick objects is discussed along with the technical features of the scanners including magnification, color depth and shadow detail. The work of pioneering scanner artist, Joseph Scheer from New York's Alfred University is highlighted. Representative flatbed-scanned images of moths are illustrated along with techniques to produce them. Collecting and preparing moths, and other objects, for scanning are described. Highlights of the Fulbright sabbatical year of professor Scheer in Arizona and Sonora, Mexico are presented, along with comments on moths in science, folklore, art and pop culture. The use of flatbed scanners is offered as a relatively new method for visualizing small objects while acquiring large files for creating archival inkjet prints for display and sale.

  18. Moths on the Flatbed Scanner: The Art of Joseph Scheer

    Directory of Open Access Journals (Sweden)

    Stephen L. Buchmann

    2011-12-01

    Full Text Available During the past decade a few artists and even fewer entomologists discovered flatbed scanning technology, using extreme resolution graphical arts scanners for acquiring high magnification digital images of plants, animals and inanimate objects. They are not just for trip receipts anymore. The special attributes of certain scanners, to image thick objects is discussed along with the technical features of the scanners including magnification, color depth and shadow detail. The work of pioneering scanner artist, Joseph Scheer from New York’s Alfred University is highlighted. Representative flatbed-scanned images of moths are illustrated along with techniques to produce them. Collecting and preparing moths, and other objects, for scanning are described. Highlights of the Fulbright sabbatical year of professor Scheer in Arizona and Sonora, Mexico are presented, along with comments on moths in science, folklore, art and pop culture. The use of flatbed scanners is offered as a relatively new method for visualizing small objects while acquiring large files for creating archival inkjet prints for display and sale.

  19. Joseph Beuys: o elemento material como agente social

    Directory of Open Access Journals (Sweden)

    Dália Rosenthal

    2011-01-01

    Full Text Available O presente artigo apresenta uma reflexão sobre o papel social do elemento material na obra, ação e pensamento do artista alemão Joseph Beuys (1921-1986. A partir da década de 1970, Beuys passou a direcionar mais seu trabalho para atividades educativas e políticas. O artista desejava ampliar os limites da arte a partir do Conceito ampliado de arte e da Teoria da Escultura, divulgados durante a década de 1960. Gradualmente, o elemento material, antes restrito às esculturas, desenhos e ações, passa a atuar socialmente. Assim, por meio da descrição e análise de cinco trabalhos de Beuys, produzidos entre 1970 e 1980, buscarei mostrar como este elemento material expande-se pouco a pouco dentro de seus próprios significados, para, ao final da vida artística de Beuys, agir como agente social.

  20. Electrical Enlightenment: Joseph Priestley's Historical and Experimental Studies of Electricity

    Science.gov (United States)

    Boantza, Victor

    Joseph Priestley (1733-1804) was one of the most controversial public figures of the eighteenth century. A true Enlightenment polymath, he wrote more than two hundred books, pamphlets, sermons, and essays on subjects ranging from science to politics and from metaphysics to theology. He was a religious dissenter, political radical, vocal supporter of the French Revolution, and lifelong defender of the losing side in the Chemical Revolution. Priestley is best known for having ``discovered'' oxygen in the 1770s and for his lasting contributions to pneumatic chemistry. Yet his first scientific fascination, while teaching at Warrington Academy, was electricity--one of the greatest scientific fads of the Enlightenment. Priestley's work on electricity, both historical and experimental, culminated in his History and Present State of Electricity (1767), which became a standard textbook on the subject for nearly a century, and went through numerous editions and translations. Situating Priestley's electrical investigations against the background of eighteenth-century ideals of scientific theory and practice, especially concerning physics, experimental philosophy, and natural history, illuminates the relations between science, society, and epistemology in the Enlightenment.

  1. Del semanario al libro: La escritura del Rosendo de Rodolfo Walsh como construcción del vandorismo en la Argentina del peronismo fracturado From the weekly to the book: The writing of Rodolfo Walsh's Rosendo as the construction of the vandorismo in the Argentina of broken Peronism

    Directory of Open Access Journals (Sweden)

    Darío Dawyd

    2012-06-01

    Full Text Available En el presente artículo se reconstruye la investigación que Rodolfo Walsh realizó sobre el enfrentamiento que costó la vida de Rosendo García, Domingo Blajaquis y Juan Zalazar y que publicó en siete notas en el semanario CGT entre el 16 de mayo y el 27 de junio de 1968. Aquellas notas son contrastadas con su publicación posterior en formato de libro como ¿Quien mató a Rosendo? en mayo de 1969 y se busca destacar las diferencias entre ambos formatos y contextos. Estas diferencias permiten relevar el contexto político acelerado en que se produjeron y la gran distancia entre un momento y otro a pesar de que transcurrió solo un año entre ambos. Con ello se pretende revisitar una de las investigaciones menos abordadas de Walsh y ponerla en contexto al interior de una etapa político-sindical poco estudiada, especialmente los significados de la división de la CGT y el peronismo, en tanto Walsh había retomado su militancia política y estrechado sus primeros vínculos con una de las fracciones del peronismo en disputa.In the present article we reconstructed Rodolfo Walsh's research about the death of Rosendo García, Domingo Blajaquis and Juan Zalazar that he published in seven notes in the weekly CGT between May and June in 1968. Those notes are compare with his later publication of the research as a the book ¿Quien mató a Rosendo? in May, 1969. We try to emphasize the differences between both formats and contexts because those differences allow as to relieve the critical political context in which they took place. The article underline of the worst approached investigations of Walsh and put it in its context of the meanings of the division of the CGT and the Peronism, considering that Walsh had taken again his political militancy and had make his first links with one of the fractions of the Peronism in dispute.

  2. The Chief Joseph Hatchery Program 2013 Annual Report

    Science.gov (United States)

    Baldwin, Casey; Pearl, Andrea; Laramie, Matthew; Rohrback, John; Phillips, Pat; Wolf, Keith

    2016-01-01

    The Chief Joseph Hatchery is the fourth hatchery obligated under the Grand Coulee Dam/Dry Falls project, originating in the 1940s. Leavenworth, Entiat, and Winthrop National Fish Hatcheries were built and operated as mitigation for salmon blockage at Grand Coulee Dam, but the fourth hatchery was not built, and the obligation was nearly forgotten. After the Colville Tribes successfully collaborated with the United States to resurrect the project, planning of the hatchery began in 2001 and construction was completed in 2013. The monitoring program began in 2012 and adult Chinook Salmon were brought on station for the first time in June 2013. BPA is the primary funding source for CJH, and the Mid-Columbia PUDs (Douglas, Grant and Chelan County) have entered into cost-share agreements with the tribes and BPA in order to meet some of their mitigation obligations. The CJH production level was set at 60% in 2013 in order to train staff and test hatchery facility systems during the first year of operation. Leavenworth National Fish Hatchery (LNFH) provided 422 Spring Chinook broodstock in June, 2013; representing the official beginning of CJH operations. In July and August the CCT used a purse seine vessel to collect 814 summer/fall Chinook as broodstock that were a continuation and expansion of the previous Similkameen Pond program. In-hatchery survival for most life stages exceeded survival targets and, as of April 2014, the program was on track to exceed the 60% production target for its start-up year. The CJH monitoring project collected field data to determine Chinook population status, trend, and hatchery effectiveness centered on five major activities; 1) rotary screw traps (juvenile outmigration, natural-origin smolt PIT tagging) 2) beach seine (naturalorigin smolt PIT tagging) 3) lower Okanogan adult fish pilot weir (adult escapement, proportion of hatchery-origin spawners [pHOS], broodstock) 4) spawning ground surveys (redd and carcass surveys)(viable salmonid

  3. Semblanza sobre la vida y obra de Joseph Alois Schumpeter

    Directory of Open Access Journals (Sweden)

    Álvaro Turriago Hoyos

    2001-12-01

    Full Text Available Joseph Alois Schumpeter se hace acreedor a una muy merecida reputación en la Historia de la Teoría Económica por su concepción original de la dinámica del Sistema Capitalista. Básicamente, él le da al empresario el papel esencial del la innovación. Schumpeter distingue entre dos períodos dentro de la evolución del Capitalismo. El primero, el Capitalismo Competitivo en el que pocas firmas empezaron a mejorar innovaciones como resultado de las acciones de un empresario heroico. El segundo, el Capitalismo Confiable, un período dominado por muchas preocupaciones y monopolios en los quela propiedad podía cambiarse gracias a la posibilidad de comprar y vender acciones en los mercados financieros. Ambos períodos demandan los efectos de las innovaciones para crecer pero, de hecho, el fuerte papel de los empresarios. La visión Schumpeteriana es básicamente dinámica. Esta visión Encuentra el origen del cambio económico en el cambio técnico que sólo se posibilita mediante la aparición de innovaciones mejoradas por los empresarios. Esta interpretación original del sistema económico desarrollado por Schumpeter fue posible debido a las fuertes influencias de los economistas marginalistas austriacos, las relaciones de producción histórica desarrolladas por Marx, el modelo de equilibrio clásico de Walras y la explicación sociológica e institucional de Weber. En este artículo se presentan tanto la vida y el trabajo de Schumpeter como la explicación de la función del Sistema Capitalista.

  4. Paraganspis egeria Díaz, Gallardo & Walsh (Hymenoptera: Figitidae: Eucoilinae as potential agent in the biocontrol of muscoid dipterous collected in several substracts in Itumbiara, Goias, Brazil

    Directory of Open Access Journals (Sweden)

    Marchiori C.H.

    2002-01-01

    Full Text Available Este estudo determinou as espécies de hospedeiros do parasitóide Paraganspis egeria (Díaz, Gallardo & Walsh, 1996 (Hymenoptera: Figitidae em esterco bovino, fezes humanas, rins de bovino, galinha e carcaça de suíno. As pupas foram obtidas pelo método de flutuação. Elas foram colocadas individualmente em cápsulas de gelatina e mantidas até a emergência das moscas e/ou parasitóides. A prevalência total de parasitismo foi de 3,4%.

  5. Joseph Smith's tritheism : the prophet's theology in context, critiqued from a Nicene perspective / Keith Dayton Hartman II

    OpenAIRE

    Hartman, Keith Dayton

    2013-01-01

    Joseph Smith is one of the most enigmatic figures in American religious history. From the details of his life story to the eventual formation of his own church, much has been written on the legacy of Joseph Smith. However, there are still numerous areas of Smith’s life and thought that demand further engagement, especially from a Nicene perspective. The purpose of the present research is to substantively add to scholarly knowledge regarding Joseph Smith. In contradistinction...

  6. Machado-Joseph disease in Brazil: from the first descriptions to the emergence as the most common spinocerebellar ataxia

    Directory of Open Access Journals (Sweden)

    José Luiz Pedroso

    2012-08-01

    Full Text Available Machado-Joseph disease is an autosomal dominant inherited disorder of Azorean ancestry firstly described in 1972. Since then, several Brazilian researchers have studied clinical and genetic issues related to the disease. Nowadays, Machado-Joseph disease is considered the most common spinocerebellar ataxia worldwide. Machado-Joseph disease still has no specific therapy to arrest progression, but the unclear pathophysiological mechanism, features related to genetic characteristics, phenotype variability, apparently global involvement of the nervous system in the disease and the therapeutic challenges continue to attract investigators in the field of spinocerebellar ataxias. Brazilian researchers have distinguished themselves in the ongoing investigation seeking new knowledge about Machado-Joseph disease.

  7. Machado-Joseph disease in Brazil: from the first descriptions to the emergence as the most common spinocerebellar ataxia.

    Science.gov (United States)

    Pedroso, José Luiz; Braga-Neto, Pedro; Radvany, João; Barsottini, Orlando Graziani Povoas

    2012-08-01

    Machado-Joseph disease is an autosomal dominant inherited disorder of Azorean ancestry firstly described in 1972. Since then, several Brazilian researchers have studied clinical and genetic issues related to the disease. Nowadays, Machado-Joseph disease is considered the most common spinocerebellar ataxia worldwide. Machado-Joseph disease still has no specific therapy to arrest progression, but the unclear pathophysiological mechanism, features related to genetic characteristics, phenotype variability, apparently global involvement of the nervous system in the disease and the therapeutic challenges continue to attract investigators in the field of spinocerebellar ataxias. Brazilian researchers have distinguished themselves in the ongoing investigation seeking new knowledge about Machado-Joseph disease.

  8. Nonmotor and extracerebellar features in Machado-Joseph disease: a review.

    Science.gov (United States)

    Pedroso, José Luiz; França, Marcondes C; Braga-Neto, Pedro; D'Abreu, Anelyssa; Saraiva-Pereira, Maria Luiza; Saute, Jonas A; Teive, Hélio A; Caramelli, Paulo; Jardim, Laura Bannach; Lopes-Cendes, Iscia; Barsottini, Orlando Graziani P

    2013-08-01

    Spinocerebellar ataxia type 3 or Machado-Joseph disease is the most common spinocerebellar ataxia worldwide, and the high frequency of nonmotor manifestations in Machado-Joseph disease demonstrates how variable is the clinical expression of this single genetic entity. Anatomical, physiological, clinical, and functional neuroimaging data reinforce the idea of a degenerative process involving extracerebellar regions of the nervous system in Machado-Joseph disease. Brain imaging and neuropathologic studies have revealed atrophy of the pons, basal ganglia, midbrain, medulla oblongata, multiple cranial nerve nuclei, and thalamus and of the frontal, parietal, temporal, occipital, and limbic lobes. This review provides relevant information about nonmotor manifestations and extracerebellar symptoms in Machado-Joseph disease. The main nonmotor manifestations of Machado-Joseph disease described in previous data and discussed in this article are: sleep disorders, cognitive and affective disturbances, psychiatric symptoms, olfactory dysfunction, peripheral neuropathy, pain, cramps, fatigue, nutritional problems, and dysautonomia. In addition, we conducted a brief discussion of noncerebellar motor manifestations, highlighting movement disorders. © 2013 Movement Disorder Society. Copyright © 2013 Movement Disorder Society.

  9. Cytokines in Machado Joseph Disease/Spinocerebellar Ataxia 3.

    Science.gov (United States)

    da Silva Carvalho, Gerson; Saute, Jonas Alex Morales; Haas, Clarissa Branco; Torrez, Vitor Rocco; Brochier, Andressa Wigner; Souza, Gabriele Nunes; Furtado, Gabriel Vasata; Gheno, Tailise; Russo, Aline; Monte, Thais Lampert; Schumacher-Schuh, Artur; D'Avila, Rui; Donis, Karina Carvalho; Castilhos, Raphael Machado; Souza, Diogo Onofre; Saraiva-Pereira, Maria Luiza; Torman, Vanessa Leotti; Camey, Suzi; Portela, Luis Valmor; Jardim, Laura Bannach

    2016-08-01

    The aim of the present study is to describe the serum concentrations of a broad spectrum of cytokines in symptomatic and asymptomatic carriers of Machado Joseph disease (SCA3/MJD) CAG expansions. Molecularly confirmed carriers and controls were studied. Age at onset, disease duration, and clinical scales Scale for the Assessment and Rating of Ataxia (SARA), Neurological Examination Score for Spinocerebellar Ataxias (NESSCA), SCA Functional Index (SCAFI), and Composite Cerebellar Functional Score (CCFS) were obtained from the symptomatic carriers. Serum was obtained from all individuals and a cytokine panel "consisted of" eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN)-α, IFN-γ, interleukin (IL)-1β, IL-1RA, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17, interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, monokine induced by gamma interferon (MIG), macrophage inflammatory protein (MIP)-a, MIP-b, regulated on activation, normal T cell expressed and secreted (RANTES) and tumor necrosis factor (TNF)-α was analyzed. In a subgroup of symptomatic carriers, the cytokine panel was repeated after 360 days. Cytokine distribution among groups was studied by discriminant analysis; changes in serum levels after 360 days were studied by generalized estimation equation. Sixty-six symptomatic carriers, 13 asymptomatic carriers, and 43 controls were studied. No differences in cytokine patterns were found between controls and carriers of the CAG expansions or between controls and symptomatic carriers only. In contrast, eotaxin concentrations were significantly higher in asymptomatic than in symptomatic carriers or in controls (p = 0.001, ANCOVA). Eotaxin did not correlate with age, disease duration, CAG expansion, NESSCA score, and SARA score. Among symptomatic carriers, eotaxin dropped after 360 days (p = 0.039, GEE). SCA3/MJD patients presented a benign pattern of

  10. Generalized localization for the double trigonometric Fourier series and the Walsh-Fourier series of functions in L log +L log + log +L

    International Nuclear Information System (INIS)

    Bloshanskaya, S K; Bloshanskii, I L; Roslova, T Y

    1998-01-01

    For an arbitrary open set Ω subset of I 2 =[0,1) 2 and an arbitrary function f element of L log + L log + log + L(I 2 ) such that f=0 on Ω the double Fourier series of f with respect to the trigonometric system Ψ=E and the Walsh-Paley system Ψ=W is shown to converge to zero (over rectangles) almost everywhere on Ω. Thus, it is proved that generalized localization almost everywhere holds on arbitrary open subsets of the square I 2 for the double trigonometric Fourier series and the Walsh-Fourier series of functions in the class L log + L log + log + L (in the case of summation over rectangles). It is also established that such localization breaks down on arbitrary sets that are not dense in I 2 , in the classes Φ Ψ (L)(I 2 ) for the orthonormal system Ψ=E and an arbitrary function such that Φ E (u)=o(u log + log + u) as u→∞ or for Φ W (u)=u( log + log + u) 1-ε , 0<ε<1

  11. Long-term therapy of a patient with summerskill-walshe-tygstrup syndrome by applying prometheus® liver dialysis: a case report.

    Science.gov (United States)

    Walensi, Mikolaj; Canbay, Ali; Witzke, Oliver; Gerken, Guido; Kahraman, Alisan

    2012-05-01

    Summerskill-Walshe-Tygstrup syndrome is a rare benign chronic liver disease characterized by recurring cholestasis with jaundice and severe pruritus. Due to insufficient conservative treatment, liver dialysis by Prometheus(®) was applied to a 45-year-old female patient with resistant pruritus. Initially, other possible liver diseases were excluded and the patient was treated symptomatically since the diagnosis of Summerskill-Walshe-Tygstrup was stated in 1998. As conservative and endoscopic methods progressively failed to relieve the patient's suffering, Prometheus(®) liver dialysis was performed regularly since 2006 at 3-month intervals and successfully led to a decrease in the patient's symptoms. Cholestatic liver enzymes and also serum bile acids could be lowered significantly from an average of 22.5 ± 2.7 to 7.3 ± 1.7 µmol/l. Consequently, Prometheus(®) liver dialysis may be a beneficial option for patients with benign recurrent intrahepatic cholestasis suffering from therapy-resistant symptoms and may be used as well as other extracorporeal liver support devices which have already been reported to improve cholestatic pruritus.

  12. Long-Term Therapy of a Patient with Summerskill-Walshe-Tygstrup Syndrome by Applying Prometheus® Liver Dialysis: A Case Report

    Directory of Open Access Journals (Sweden)

    Mikolaj Walensi

    2012-08-01

    Full Text Available Summerskill-Walshe-Tygstrup syndrome is a rare benign chronic liver disease characterized by recurring cholestasis with jaundice and severe pruritus. Due to insufficient conservative treatment, liver dialysis by Prometheus® was applied to a 45-year-old female patient with resistant pruritus. Initially, other possible liver diseases were excluded and the patient was treated symptomatically since the diagnosis of Summerskill-Walshe-Tygstrup was stated in 1998. As conservative and endoscopic methods progressively failed to relieve the patient’s suffering, Prometheus® liver dialysis was performed regularly since 2006 at 3-month intervals and successfully led to a decrease in the patient’s symptoms. Cholestatic liver enzymes and also serum bile acids could be lowered significantly from an average of 22.5 ± 2.7 to 7.3 ± 1.7 µmol/l. Consequently, Prometheus® liver dialysis may be a beneficial option for patients with benign recurrent intrahepatic cholestasis suffering from therapy-resistant symptoms and may be used as well as other extracorporeal liver support devices which have already been reported to improve cholestatic pruritus.

  13. Disartria e doença de Machado-Joseph: relato de caso Dysarthria in Machado-Joseph disease: case report

    Directory of Open Access Journals (Sweden)

    Angela Ruviaro Busanello

    2007-09-01

    Full Text Available O objetivo deste estudo foi descrever os principais aspectos fonoaudiológicos relacionados à fala na doença de Machado-Joseph, em um indivíduo do sexo masculino, selecionado entre outros pacientes portadores desta doença com limitações significativas de fala. O paciente foi atendido no Setor de Fonoaudiologia do Serviço de Fisiatria do Hospital de Clínicas de Porto Alegre. Especificamente quanto à fala e seus processos, observou-se quadro disártrico predominantemente atáxico, que piorou com a evolução da doença, passando de leve para severo. Estes resultados permitiram a conclusão de que as alterações tornam-se significativas na fala do portador de doença de Machado-Joseph, associadas ao comprometimento da respiração, articulação, fonação e ressonância. Concluiu-se também quanto à importância do tratamento fonoaudiológico na doença de Machado-Joseph, sugerindo-se novos estudos, com número maior de indivíduos, sejam realizados, a fim de melhor caracterizar as alterações de fala observadas neste estudo.The aim of this study was to describe the essential speech aspects of Machado-Joseph disease in a male patient with this diagnosis, selected among others with the same disease that received treatment at the Speech-Language Pathology and Audiology department of Hospital de Clínicas de Porto Alegre (Brazil. Regarding the speech process, it was observed ataxic dysarthria, which worsened from light to severe with the evolution of the disease. These results allowed the conclusion that speech alterations become more and more significant for Machado-Joseph patients, together with deficits in breathing, articulation, phonation and resonance. Finally, it was possible to suggest that Speech Pathology treatment is essential in Machado-Joseph disease, although more studies are necessary, with larger samples, in order to better characterize the speech alterations observed this study.

  14. Saint Joseph's University Institute for Environmental Stewardship

    Energy Technology Data Exchange (ETDEWEB)

    McCann, Micahel P. [Saint Joseph' s Univ., Philadelphia, PA (United States); Springer, Clint J. [Saint Joseph' s Univ., Philadelphia, PA (United States)

    2014-06-03

    future climate scenarios is local adaptation and not necessarily genome size as has been hypothesized in the literature. Task B: Installation of an extensive green roof system on the Science Center at Saint Joseph's University for research, research-training and educational outreach activities. An experimental green roof system was designed and installed by an outside contractor (Roofmeadows) on the roof of the Science Center at Saint Joseph's University. The roof system includes four test plots, each with a different drainage system, instrumentation to monitor storm water retention, roof deck temperature, heat flux into and out of the building, rain fall, wind speed and direction, relative humidity and heat emission from the roof system. The vegetative roof was planted with 26 species of plants, distributed throughout the roof area, to assess species/variety growth and coverage characteristics, both in terms of the different drain layer systems, and in terms of the different exposures along the north to south axis of the building. Analysis of the drain layer performance, in terms of storm water retention, shows that the aggregate (stone) drainage layer system performed the best, with the moisture management mat system second, and the geotextile drain layer and reservoir sheet layer systems coming in last. This information is of value in the planning and design of vegetative roof systems since the different types of drainage layer systems have different installation costs and different weights. The different drainage layer systems also seem to be having an impact on plant growth and spread with the test plot with the reservoir sheet layer actually having the poorest plant coverage and plant spread of all areas of the roof studied. Plant growth performance analysis is ongoing, but significant differences have been observed in the third growing season ('13) along the north to south axis, with most species doing better towards the northern end of the roof (in

  15. BOOK REVIEW: Joseph Henry: The Rise of an American Scientist

    Science.gov (United States)

    Crawford, Elspeth

    1998-09-01

    Albert Moyer has clearly done his research into the events of Joseph Henry's life. The personal, professional, sociological and scientific aspects have been meticulously detailed throughout and the ordering, as in the chapter headings, is chronological, so that there is some element of each of these aspects in each chapter. This is unfortunately both the strength and the weakness of the biography, as the detail seemed to me to be the most remarkable characteristic of the writing. But, the bigger stories, or the themes, which might have been possible, seemed to get lost. Hence, I found this a book for those who are seriously interested in Joseph Henry; but for those whose interest might be more general, say having an interest in nineteenth century growth of scientific institutions, or wanting to understand the conceptual development of electromagnetism, there seemed to be too much which came from the Henry point of view, rather than locating Henry within his time and context. This is a remark about style, rather than omission of content, as the myriad of details in each paragraph certainly inform the reader about the context. For instance, some sociology of the USA in the nineteenth century could be inferred, say showing how a young man from a modest background might make his way into a professional life, but the information is so particularly a description of Henry's experience that one has to rely on prior knowledge or make assumptions in order to create a sociological perspective. That is, I now know, what happened to Henry, but I do not know if his case was in any sense typical or atypical. Similarly there is information about education in general at that time, and scientific education, research and its publication, as it applied to Henry. The relationships between science in the USA and in Europe have a place, and there is quite a bit of information about the institutions in which Henry worked, particularly Albany Academy, Princeton and the Smithsonian. Henry

  16. IN THE EARLY JOSEPH ALOIS JULIUS SCHUMPETER'S FOOTSTEPS - MARRIAGE, TRAGEDY AND EMIGRATION

    Directory of Open Access Journals (Sweden)

    J-U. Sandal

    2015-10-01

    Full Text Available At the age of 42 Joseph Alois Schumpeter married the 20 years younger Anna (“Annie” Josefina Reisinger. Joseph Schumpeter is looking forward to being a father, and the couple have a child, Joseph, but both Annie and the baby dies during confinement. The tragedy is a fact, and Schumpeter loses the joy of scientific creativity and concentration. His existence is concurrently burdened by private financial problems. He holds fast to his creative youth work, Theorie der wirtschaftlichen Entwicklung, which is a companion through life and the foundation stone of modern entrepreneurial research worldwide. The article analyzes the important events in Schumpeter’s life and its importance to scientific development in economic theory.

  17. Biblisch-koranische Figuren – feminin: Jesus, Joseph and Job Characters from the Bible and the Quran—Feminine: Jesus, Joseph and Job

    Directory of Open Access Journals (Sweden)

    Barbara Winckler

    2003-07-01

    Full Text Available Jesus, Joseph and Job stellt drei Texte aus der Feder zeitgenössischer libanesischer Autorinnen vor, die auf unterschiedliche Weise die Geschichten religiöser Figuren neu schreiben, und diskutiert sie im Hinblick auf ihr subversives Potential für gesellschaftlichen Wandel. Dazu werden in der Analyse neben der Intertextualität Konzepte genderorientierter und postkolonialer Ansätze wie métissage und borderlands herangezogen.In Jesus, Joseph and Job Hartman introduces three texts, written by contemporary Lebanese women authors who re-write the history of religious characters, and discusses these texts with respect to their subversive potential for societal change. In her analysis, Hartman does not only use intertextuality, but also gender-informed and post-colonial approaches such as, métissage and border spaces.

  18. [The vitalism of Paul-Joseph Barthez (1734-1806)].

    Science.gov (United States)

    Han, Hee Jin

    2010-06-30

    In The Logic of Life (1970), Francois Jacob (1920- ), Nobel Prize laureate in Physiology or Medicine (1965), proclaimed the end of vitalism based on the concept of life. More than two decades before this capital sentence condemning vitalism was pronounced, Georges Canguilhem (1904-1995), a French philosopher of medicine, already acknowledged that eighteenth-century vitalism was scientifically retrograde and politically reactionary or counter-revolutionary insofar as it was rooted in the animism of Georg Ernst Stahl (1660-1734). The negative preconception of the term 'vitalism' came to be established as an orthodox view, since Claude Bernard (1813-1878) unfairly criticized contemporary vitalism in order to propagate his idea of experimental medicine. An eminent evolutionary biologist like Ernst Mayr (1904-2005) still defended similar views in This is Biology (1997), arguing that if vitalists were decisive and convincing in their rejection of the Cartesian model (negative heuristics), however they were equally indecisive and unconvincing in their own explanatory endeavors (positive heuristics). Historically speaking, vitalists came to the forefront for their outstanding criticism of Cartesian mechanism and physicochemical reductionism, while their innovative concepts and theories were underestimated and received much less attention. Is it true that vitalism was merely a pseudo-science, representing a kind of romanticism or mysticism in biomedical science? Did vitalists lack any positive heuristics in their biomedical research? Above all, what was actually the so.called 'vitalism'? This paper aims to reveal the positive heuristics of vitalism defined by Paul.Joseph Barthez (1734-1806) who was the founder of the vitalist school of Montpellier. To this end, his work and idea are introduced with regard to the vying doctrines in physiology and medicine. At the moment when he taught at the medical school of Montpellier, his colleagues advocated the mechanism of Rene

  19. god's holy spirit: a back- story from the joseph narrative (genesis 37 ...

    African Journals Online (AJOL)

    ABSTRACT. The story of Judah within the longer Joseph story (Genesis 37-50) provides an apt .... intention, character psychology. ..... For him, the clearest moment to see this moment in the authoring dynamic is in the life of Jesus. His self-understanding, his orientation toward God, his manner of relatedness to others are all ...

  20. Highlighting High Performance: Adam Joseph Lewis Center for Environmental Studies, Oberlin College, Oberlin, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    2002-11-01

    Oberlin Colleges Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials that are local, non-toxic, and durable.

  1. Highlighting High Performance Buildings: Adam Joseph Lewis Center for Environmental Studies

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-11-01

    Oberlin College's Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials that are local, non-toxic, and durable.

  2. Reflections on Preparing Educators to Evaluate the Efficacy of Educational Technology: An Interview with Joseph South

    Science.gov (United States)

    Bull, Glen; Spector, J. Michael; Persichitte, Kay; Meiers, Ellen

    2017-01-01

    Joseph South, an educational researcher, technology consultant, and former director of the U.S. Office of Educational Technology participated in a research initiative on Educational Technology Efficacy Research organized by the Jefferson Education Accelerator, Digital Promise, and the Curry School of Education at the University of Virginia. The…

  3. Origins and Spread of Machado-Joseph Disease Ancestral Mutations Events.

    Science.gov (United States)

    Martins, Sandra; Sequeiros, Jorge

    2018-01-01

    Machado-Joseph disease (MJD) is the most common autosomal dominant spinocerebellar ataxia reported worldwide, but it shows marked geographic differences in prevalence. The study of ancestral origins and spreading routes of MJD mutational events has contributed to explain such differences. During human evolution, at least two independent de novo MJD expansions occurred in distinct haplotype backgrounds: TTACAC and GTGGCA (named Joseph and Machado lineages). The most ancient Joseph lineage, probably of Asian origin, has been introduced recently in Europe, where founder effects are responsible for the high MJD prevalence, as occurs in the Portuguese/Azorean island of Flores and Northeastern mainland. The Machado lineage is geographically more restricted, with most known families in Portugal (island of São Miguel and along the Tagus valley). The hypothesis of other mutational origins has been raised, namely to explain the disease among Australian aborigines; however, a comprehensive haplotype study suggested the introduction of the Joseph lineage in that community via Asia. Also, additional SNP-based haplotypes (TTAGAC, TTGGAC and GTGCCA) were observed in other MJD families, but phylogenetic analysis with more polymorphic flanking markers did not point to independent mutational events, reinforcing the hypothesis of a very low mutation rate underlying this repeat expansion locus.

  4. Spinocerebellar ataxia type 3/Machado-Joseph disease starting before adolescence

    NARCIS (Netherlands)

    Donis, Karina Carvalho; Saute, Jonas Alex Morales; Krum-Santos, Ana Carolina; Furtado, Gabriel Vasata; Mattos, Eduardo Preusser; Saraiva-Pereira, Maria Luiza; Torman, Vanessa Leotti; Jardim, Laura Bannach

    Onset of Machado-Joseph disease (SCA3/MJD) before adolescence has been rarely reported. This study aims to describe a cohort of SCA3/MJD with onset before 12 years of age, comparing their disease progression with the progression observed in patients with usual disease onset. We identified all cases

  5. Riotous Images: Representations of Joseph Priestley in British Prints during the French Revolution

    Science.gov (United States)

    Clay, Richard

    2008-01-01

    This article focuses on printed images that were published in Britain during the 1790s, depicting the educationist, theologian, chemist, physicist, historian and philosopher Joseph Priestley (1733-1804). It is argued that such etchings and engravings are indicative of, and contributed to, the lifelong political and historical education of late…

  6. A Short Biography of Joseph Fourier and Historical Development of Fourier Series and Fourier Transforms

    Science.gov (United States)

    Debnath, Lokenath

    2012-01-01

    This article deals with a brief biographical sketch of Joseph Fourier, his first celebrated work on analytical theory of heat, his first great discovery of Fourier series and Fourier transforms. Included is a historical development of Fourier series and Fourier transforms with their properties, importance and applications. Special emphasis is made…

  7. Ethnographic Research and Globalization: A Discussion of Joseph Tobin's Model of Video-Cued Multivocal Ethnography

    Science.gov (United States)

    Watras, Joseph

    2014-01-01

    Joseph Tobin made an impact on the field of comparative education in 2009 when he used a unique form of ethnography to illuminate the effects of world-wide forces, such as modernization, on schools in specific countries. Earlier, in 1989, he published "Preschool in Three Cultures" with co-authors David Wu and Dana Davidson. The…

  8. Paula Coutinho's outstanding contribution to the definition of Machado-Joseph disease.

    Science.gov (United States)

    Garcia, Bruno Carniatto Marques; Germiniani, Francisco Manoel Branco; Marques, Paula; Sequeiros, Jorge; Teive, Hélio Afonso Ghizoni

    2017-10-01

    Machado-Joseph disease, also known as spinocerebellar ataxia type 3, is the most common form of autosomal dominant ataxia in the world. Paula Coutinho, a highly-regarded Portuguese neurologist worldwide, had a seminal participation in the definition of this disease, more than 40 years ago.

  9. USA saadik loodab võita eestlaste poolehoiu / Joseph M. DeThomas

    Index Scriptorium Estoniae

    DeThomas, Joseph M.

    2003-01-01

    USA suursaadik Eestis Joseph DeThomas vastab on-line intervjuus Eesti Päevalehe lugejate küsimustele Iraagi ründamise, USA ja Euroopa vahelise lõhe, USA Eesti saatkonna võimaliku ümberkolimise kohta

  10. Toward a Telic Vision of Human Beings: A Dialogue with Joseph F. Rychlak.

    Science.gov (United States)

    Howard, George S.

    1987-01-01

    Presents interview with Joseph F. Rychlak on topics of notions of causality in science, relationship of research to practice in humanistic psychology, research evidence for a telic view of human action, counseling active agents, choice and free will, and philosophy of science and humanisitic theory. (ABL)

  11. Joseph Pulitzer II and Advertising Censorship, 1929-1939. Journalism Monographs Number Seventy-seven.

    Science.gov (United States)

    Pfaff, Daniel W.

    In an age of little or no consumer protection, the St. Louis "Post-Dispatch," under the guidance of Joseph Pulitzer II, was the first and most successful practitioner of self-imposed censorship of advertising, a practice that continues to this day. Beginning on May 1, 1929, the "Post-Dispatch" announced an aggressive program of…

  12. Spinocerebellar ataxia type 3 (Machado-Joseph disease) : severe destruction of the lateral reticular nucleus

    NARCIS (Netherlands)

    Rub, U; de Vos, RAI; Schultz, C; Brunt, ER; Paulson, H; Braak, H

    The lateral reticular nucleus (LRT) of the medulla oblongata is a precerebellar nucleus involved in proprioception and somatomotor automatisms. We investigated this nucleus in five individuals with clinically diagnosed and genetically confirmed spinocerebellar ataxia type 3 (SCA3, Machado-Joseph

  13. Joseph Pennell and the Anglo-American Construction of New York

    Directory of Open Access Journals (Sweden)

    Margaret J. Schmitz

    2017-05-01

    Full Text Available American printmaker Joseph Pennell’s iconic New York imagery is the focus of this article, including an exploration of his efforts to find an appropriate aesthetic language for Manhattan’s unparalleled new skyscrapers in light of his experience as a transatlantic artist.

  14. Cervical and ocular vestibular evoked potentials in Machado-Joseph disease: Functional involvement of otolith pathways.

    Science.gov (United States)

    Ribeiro, Rodrigo Souza; Pereira, Melissa Marques; Pedroso, José Luiz; Braga-Neto, Pedro; Barsottini, Orlando Graziani Povoas; Manzano, Gilberto Mastrocola

    2015-11-15

    Machado-Joseph disease is defined as an autosomal dominant ataxic disorder caused by degeneration of the cerebellum and its connections and is associated with a broad range of clinical symptoms. The involvement of the vestibular system is responsible for several symptoms and signs observed in the individuals affected by the disease. We measured cervical and ocular vestibular evoked myogenic potentials in a sample of Machado-Joseph disease patients in order to assess functional pathways involved. Bilateral measures of cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP) were obtained from 14 symptomatic patients with genetically proven Machado-Joseph disease and compared with those from a control group of 20 healthy subjects. Thirteen (93%) patients showed at least one abnormal test result; oVEMP and cVEMP responses were absent in 17/28 (61%) and 11/28 (39%) measures, respectively; and prolonged latency of cVEMP was found in 3/28 (11%) measures. Of the 13 patients with abnormal responses, 9/13 (69%) patients showed discordant abnormal responses: four with absent oVEMP and present cVEMP, two with absent cVEMP and present oVEMP, and three showed unilateral prolonged cVEMP latencies. Both otolith-related vestibulocollic and vestibulo-ocular pathways are severely affected in Machado-Joseph disease patients evaluated by VEMPs. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. 77 FR 3797 - Joseph Deluca, D.O.; Dismissal of Proceeding

    Science.gov (United States)

    2012-01-25

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Joseph Deluca, D.O.; Dismissal of Proceeding On July 16, 2010, the Deputy Assistant Administrator, Office of Diversion Control, Drug Enforcement... relieve the State of its constitutional obligation.'' Id. at 232 (quoting Brief for United States as...

  16. Psi Chi/APA Edwin B. Newman Graduate Research Award: Joseph H. Hammer

    Science.gov (United States)

    American Psychologist, 2009

    2009-01-01

    Joseph H. Hammer, recipient of the Psi Chi/APA Edwin B. Newman Graduate Research Award, is cited for an outstanding research paper whose findings provide important evidence regarding the promise of a male-sensitive approach to mental health marketing and empirically support the inclusion of theory-driven enhancements in group-targeted mental…

  17. Joseph M. Nyasani It is not only astronomers who have been ...

    African Journals Online (AJOL)

    THE UBICATION OF THE PHYSICAL UNIVERSE. Joseph M. Nyasani. It is not only astronomers who have been wondering about what lies beyond the planetary system and the extent of that reality in terms of the space it occupies. Philosophers have equally been baffled by this same question even though it may not be fair ...

  18. 75 FR 73135 - Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Environmental Assessment...

    Science.gov (United States)

    2010-11-29

    ... operation of the Joseph M. Farley Nuclear Plant, Units 1 and 2 (FNP), located in Houston County, Alabama. In... Identification of the Proposed Action The proposed action would exempt the FNP from the required implementation date of March 31, 2010, for several new requirements of 10 CFR Part 73. Specifically, FNP would be...

  19. Joseph McCabe: A Forgotten Early Populariser of Science and Defender of Evolution

    Science.gov (United States)

    Cooke, Bill

    2010-01-01

    Joseph McCabe (1867-1955) was one of the most prolific and gifted polymaths of the twentieth century. Long before such a thing was thought respectable, and almost a century before any university established a chair in the public understanding of science, McCabe made a living as a populariser of science and a critic of philosophical and religious…

  20. Sintaxis del espanto, sintaxis militante: de la resistencia individual a la colectiva: una lectura de los epílogos de «Operación Masacre» de Rodolfo Walsh

    Directory of Open Access Journals (Sweden)

    Graciela Foglia

    2011-10-01

    Full Text Available Resumo: O objetivo deste trabalho é comentar os epílogos de cada uma das edições de Operación masacre (1957, 1964, 1969, 1972 de Rodolfo Walsh e mais um capítulo, o 37, “Aramburu y el juicio histórico” (1972, tendo como base teórica as reflexões sobre as relações entre literatura e testemunho. A opção por pensar cada um desses capítulos como parte da mesma seqüência se deve a que é aí onde melhor pode se acompanhar o percurso que indica uma convergência entre as instancias do narrador, do autor e do cidadão.Palavras-chave: Rodolfo Walsh; Operación masacre; literatura; testemunho.Resumen: El objetivo de este trabajo es comentar los epílogos de cada una de las ediciones de Operación masacre (1957, 1964, 1969, 1972 de Rodolfo Walsh y un capítulo más, el 37, “Aramburu y el juicio histórico” (1972, teniendo como base teórica la reflexión sobre las relaciones entre literatura y testimonio. La opción por pensar cada uno de esos capítulos como parte de la misma secuencia se debe a que es allí donde mejor se acompaña el recorrido que indica una convergencia entre las instancias de narrador, autor y ciudadano.Palabras-clave: Rodolfo Walsh; Operación masacre; literatura; testimonio.Keywords: Rodolfo Walsh; Operación masacre; literature; testimony.

  1. Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.

    Science.gov (United States)

    Mendonça, Liliana S; Nóbrega, Clévio; Hirai, Hirokazu; Kaspar, Brian K; Pereira de Almeida, Luís

    2015-02-01

    Machado-Joseph disease is a neurodegenerative disease without effective treatment. Patients with Machado-Joseph disease exhibit significant motor impairments such as gait ataxia, associated with multiple neuropathological changes including mutant ATXN3 inclusions, marked neuronal loss and atrophy of the cerebellum. Thus, an effective treatment of symptomatic patients with Machado-Joseph disease may require cell replacement, which we investigated in this study. For this purpose, we injected cerebellar neural stem cells into the cerebellum of adult Machado-Joseph disease transgenic mice and assessed the effect on the neuropathology, neuroinflammation mediators and neurotrophic factor levels and motor coordination. We found that upon transplantation into the cerebellum of adult Machado-Joseph disease mice, cerebellar neural stem cells differentiate into neurons, astrocytes and oligodendrocytes. Importantly, cerebellar neural stem cell transplantation mediated a significant and robust alleviation of the motor behaviour impairments, which correlated with preservation from Machado-Joseph disease-associated neuropathology, namely reduction of Purkinje cell loss, reduction of cellular layer shrinkage and mutant ATXN3 aggregates. Additionally, a significant reduction of neuroinflammation and an increase of neurotrophic factors levels was observed, indicating that transplantation of cerebellar neural stem cells also triggers important neuroprotective effects. Thus, cerebellar neural stem cells have the potential to be used as a cell replacement and neuroprotective approach for Machado-Joseph disease therapy. © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. Transcranial sonography findings in spinocerebellar ataxia type 3 (Machado-Joseph disease): a cross-sectional study.

    Science.gov (United States)

    Pedroso, José Luiz; Bor-Seng-Shu, Edson; Felício, Andre Carvalho; Braga-Neto, Pedro; Teixeira, Manoel Jacobsen; Barsottini, Orlando Graziani

    2011-10-24

    Few studies on transcranial brain sonography have been performed in hereditary and non-hereditary ataxias. The objective of the present study was to report transcranial brain sonography findings in a sample of clinically and molecularly proven Machado-Joseph disease patients and to compare these data against those of an age- and gender-matched control group. A cross-sectional study on transcranial brain sonography was conducted in 30 Machado-Joseph disease patients. Transcranial brain sonography was performed by an experienced sonographer blinded to the clinical, genetic, and neuroimaging data. The results were compared with those of a control group of 44 healthy subjects matched for age and gender. The sonographic findings were also correlated with clinical features and genetic data in Machado-Joseph disease group. A significantly higher frequency of substantia nigra and lenticular nucleus hyperechogenicity was found in the Machado-Joseph disease group compared to an age- and gender-matched healthy control group (pMachado-Joseph disease patients than in the control subjects. No significant correlations were found between transcranial brain sonography findings and Machado-Joseph disease demographic/clinical data. Transcranial brain sonography findings in Machado-Joseph disease patients differed significantly to those in age- and gender-matched controls. Substantia nigra hyperechogenicity occurred frequently in Machado-Joseph disease patients and was found to be the best predictor for differentiating cases from controls. Additionally, this data describes the occurrence of brain atrophy in Machado-Joseph disease group. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  3. Patents and Technological Progress in a Globalized World-Liber Amicorum Joseph Straus

    DEFF Research Database (Denmark)

    Minssen, Timo

    2012-01-01

    On December 14th, 2008, one of the world's most renowned patent scholars, Prof. Dr. Dres. h.c. Joseph Straus, celebrated his 70th birthday. Shortly thereafter, a great number of colleagues and friends gathered in his "academic home", the Max Planck Institute at Munich's Marstallplatz to congratul......On December 14th, 2008, one of the world's most renowned patent scholars, Prof. Dr. Dres. h.c. Joseph Straus, celebrated his 70th birthday. Shortly thereafter, a great number of colleagues and friends gathered in his "academic home", the Max Planck Institute at Munich's Marstallplatz...... and teaching, but also in creating the Munich Intellectual Property Law Centre and in leading, developing and administering academic endeavors at the famous Max Planck Institute for Intellectual Property, Competition and Tax Law with its tremendous library and research net-work. In over 900 pages this so...

  4. Five cases of a Joseph disease family with non-REM sleep apnea and MRI study

    International Nuclear Information System (INIS)

    Kitamura, Junichi; Tsuruta, Kazuhito; Yamamura, Yoshinori; Kurihara, Teruyuki; Matsukura, Shigeru

    1987-01-01

    Four male and one female patients of a new Joseph disease family in southern Kyushu are presented. This disorder is inherited by autosomal dominant trait. The clinical symptoms are characterized by bulging eyes, ophthalmoplegia, dysarthria, rigospasticity of the lower limbs, marked dystonia and bradykinesia. In our cases, extrapyramidal symptoms were improved by amantadine and L-Dopa therapy. CSF homovanilic acid (HVA) was markedly reduced. Muscle biopsy and electromyographic studies revealed neurogenic changes. MRI revealed mild atrophy of frontal lobe and cerebellum, and marked atrophy of brain stem. These findings were consistent with the clinical manifestations. Our case had central type sleep apnea by sleep EEG and polygraphic studies. This is the first report about sleep apnea and MRI of Joseph disease. (author)

  5. Five cases of a Joseph disease family with non-REM sleep apnea and MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Kitamura, Junichi; Tsuruta, Kazuhito; Yamamura, Yoshinori; Kurihara, Teruyuki; Matsukura, Shigeru

    1987-09-01

    Four male and one female patients of a new Joseph disease family in southern Kyushu are presented. This disorder is inherited by autosomal dominant trait. The clinical symptoms are characterized by bulging eyes, ophthalmoplegia, dysarthria, rigospasticity of the lower limbs, marked dystonia and bradykinesia. In our cases, extrapyramidal symptoms were improved by amantadine and L-dopa therapy. CSF homovanilic acid (HVA) was markedly reduced. Muscle biopsy and electromyographic studies revealed neurogenic changes. MRI revealed mild atrophy of frontal lobe and cerebellum, and marked atrophy of brain stem. These findings were consistent with the clinical manifestations. Our case had central type sleep apnea by sleep EEG and polygraphic studies. This is the first report about sleep apnea and MRI of Joseph disease.

  6. Green sea turtle age, growth, and population characteristics in St. Joseph Bay, Florida from 1998 to 2010 (NCEI Accession 0159273)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains morphology, sex ratio, body condition, disease status, age structure, and growth patterns of 448 green sea turtles cold stunned in St. Joseph...

  7. Machado-Joseph disease in a Nigerian family: mutational origin and review of the literature.

    Science.gov (United States)

    Ogun, Shamsideen Abayomi; Martins, Sandra; Adebayo, Philip B; Dawodu, Clara O; Sequeiros, Jorge; Finkel, Michael F

    2015-02-01

    Machado-Joseph disease (MJD) has been described in Africans, but no cases have been reported from Nigeria. Current MJD global distribution results from both the ancestral populations-of-origin and the founder effects of mutations, some as a consequence of the Portuguese sea travels in the 15th to 16th century. Two main ancestral haplotypes have been identified: the Machado lineage, which is more recent, predominant in families of Portuguese extraction, and the Joseph lineage, which is much older and worldwide spread, postulated to have an Asian origin. We report a Nigerian family with MJD from Calabar, once settled by Portuguese slave traders, and assessed its mutational origin. The proband was a 33-year-old man with progressive unsteady gait, weakness of all limbs, dysphagia, dysarthria, urinary frequency and diaphoresis. He had end-of-gaze nystagmus, spastic quadriparesis and atrophic small muscles of the hand. He showed fibrillation potentials on EMG, and nerve conduction studies suggested a central axonopathy without demyelination. This family bears the Joseph haplotype, which has a founder effect in the island of Flores, in the Azores (and their descendants in North-America), but is also the most common in non-Portuguese populations worldwide, with an estimated mutation age of around 7000 years.

  8. Notes on Scolytus fagi Walsh 1867 with the ignation of a neotype, distribution notes and Key to Scolytus Geoffroy of America east the Mississippi River (Coleoptera, Curculionidae, Scolytinae, Scolytini)

    Science.gov (United States)

    Smith, Sarah M.; Cognato, Anthony I.

    2010-01-01

    Abstract The identification of Scolytus fagi Walsh has been difficult because of the lack of diagnostic literature, the occurrence of several morphologically similar sympatric Scolytus species and the loss of the syntypes. In an effort to reduce taxonomic confusion, we designate a neotype for Scolytus fagi, redescribe the male and female, add new distributional records and create a key for the identification of eastern Scolytus species. PMID:21594170

  9. Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease.

    Science.gov (United States)

    Raposo, Mafalda; Bettencourt, Conceição; Maciel, Patrícia; Gao, Fuying; Ramos, Amanda; Kazachkova, Nadiya; Vasconcelos, João; Kay, Teresa; Rodrigues, Ana João; Bettencourt, Bruno; Bruges-Armas, Jácome; Geschwind, Daniel; Coppola, Giovanni; Lima, Manuela

    2015-06-01

    Machado-Joseph disease (or spinocerebellar ataxia type 3) is a late-onset polyglutamine neurodegenerative disorder caused by a mutation in the ATXN3 gene, which encodes for the ubiquitously expressed protein ataxin-3. Previous studies on cell and animal models have suggested that mutated ataxin-3 is involved in transcriptional dysregulation. Starting with a whole-transcriptome profiling of peripheral blood samples from patients and controls, we aimed to confirm abnormal expression profiles in Machado-Joseph disease and to identify promising up-regulated genes as potential candidate biomarkers of disease status. The Illumina Human V4-HT12 array was used to measure transcriptome-wide gene expression in peripheral blood samples from 12 patients and 12 controls. Technical validation and validation in an independent set of samples were performed by quantitative real-time polymerase chain reaction (PCR). Based on the results from the microarray, twenty six genes, found to be up-regulated in patients, were selected for technical validation by quantitative real-time PCR (validation rate of 81% for the up-regulation trend). Fourteen of these were further tested in an independent set of 42 patients and 35 controls; 10 genes maintained the up-regulation trend (FCGR3B, CSR2RA, CLC, TNFSF14, SLA, P2RY13, FPR2, SELPLG, YIPF6, and GPR96); FCGR3B, P2RY13, and SELPLG were significantly up-regulated in patients when compared with controls. Our findings support the hypothesis that mutated ataxin-3 is associated with transcription dysregulation, detectable in peripheral blood cells. Furthermore, this is the first report suggesting a pool of up-regulated genes in Machado-Joseph disease that may have the potential to be used for fine phenotyping of this disease. © 2015 International Parkinson and Movement Disorder Society. © 2015 International Parkinson and Movement Disorder Society.

  10. Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.

    Science.gov (United States)

    Nascimento-Ferreira, Isabel; Santos-Ferreira, Tiago; Sousa-Ferreira, Lígia; Auregan, Gwennaëlle; Onofre, Isabel; Alves, Sandro; Dufour, Noëlle; Colomer Gould, Veronica F; Koeppen, Arnulf; Déglon, Nicole; Pereira de Almeida, Luís

    2011-05-01

    Machado-Joseph disease, also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 misfolding, intracellular accumulation of aggregates and neuronal degeneration. Here we investigated the implication of autophagy, the major pathway for organelle and protein turnover, in the accumulation of mutant ataxin-3 aggregates and neurodegeneration found in Machado-Joseph disease and we assessed whether specific stimulation of this pathway could mitigate the disease. Using tissue from patients with Machado-Joseph disease, transgenic mice and a lentiviral-based rat model, we found an abnormal expression of endogenous autophagic markers, accumulation of autophagosomes and decreased levels of beclin-1, a crucial protein in the early nucleation step of autophagy. Lentiviral vector-mediated overexpression of beclin-1 led to stimulation of autophagic flux, mutant ataxin-3 clearance and overall neuroprotective effects in neuronal cultures and in a lentiviral-based rat model of Machado-Joseph disease. These data demonstrate that autophagy is a key degradation pathway, with beclin-1 playing a significant role in alleviating Machado-Joseph disease pathogenesis.

  11. Keeper of the nuclear conscience the life and work of Joseph Rotblat

    CERN Document Server

    Brown, Andrew

    2012-01-01

    Joseph Rotblat was the Jewish nuclear scientist whose disillusionment with nuclear weapons encouraged him to become one of the prime architects of the anti-nuclear movement, and resulted in his lifelong efforts to promote social responsibility in science. His founding of Pugwash and his humanitarian work ultimately led to his being awarded the Nobel Peace Prize. Rotblat's life, from his boyhood in Warsaw under siege and occupation in World War I to an active old age that brought honours and public recognition, is a compelling human story in itself. What gave it significance is the single-minde

  12. Johann Joseph on Geometrical-Optical Illusions: A Translation and Commentary.

    Science.gov (United States)

    Wade, Nicholas J; Todorović, Dejan; Phillips, David; Lingelbach, Bernd

    2017-01-01

    The term geometrical-optical illusions was coined by Johann Joseph Oppel (1815-1894) in 1855 in order to distinguish spatial distortions of size and orientation from the broader illusions of the senses. We present a translation of Oppel's article and a commentary on the material described in it. Oppel did much more than give a name to a class of visual spatial distortions. He examined a variety of figures and phenomena that were precursors of later, named illusions, and attempted to quantify and interpret them.

  13. Johann Joseph Oppel (1855) on Geometrical–Optical Illusions: A Translation and Commentary

    Science.gov (United States)

    Todorović, Dejan; Phillips, David; Lingelbach, Bernd

    2017-01-01

    The term geometrical–optical illusions was coined by Johann Joseph Oppel (1815–1894) in 1855 in order to distinguish spatial distortions of size and orientation from the broader illusions of the senses. We present a translation of Oppel’s article and a commentary on the material described in it. Oppel did much more than give a name to a class of visual spatial distortions. He examined a variety of figures and phenomena that were precursors of later, named illusions, and attempted to quantify and interpret them. PMID:28694957

  14. Joseph Lister (1827-1912): a pioneer of antiseptic surgery remembered a century after his death.

    Science.gov (United States)

    Jessney, Benn

    2012-08-01

    Joseph Lister was a remarkable British surgeon who pioneered principles of antisepsis. He died 100 years ago after devoting his life to developing and promoting safe, antiseptic surgery. In the 1800 s as many as 80% of all operations resulted in infection but many people refused to accept the true nature of infection, believing instead that the deaths were coincidental. Lister became familiar with the work of Pasteur while working in Glasgow. He recognized the truth in Pasteur's work and in 1867 Lister published his landmark paper 'On the Antiseptic Principle in the Practice of Surgery' in the British Medical Journal. It proved to be a turning point in healthcare.

  15. A discussion of stock market speculation by Pierre-Joseph Proudhon

    OpenAIRE

    Jean-Claude Juhel; Dominique Dufour

    2008-01-01

    International audience; The object of this contribution is to present the ideas behind the thinking of the French economist Pierre-Joseph Proudhon (1809-1865) in relation to the causes and effects of Stock market speculation. It is based upon the works of this author but particularly on his “Manuel du spéculateur à la Bourse” (Stock Market Speculator Manual) edited in 1857 in Paris. Compared to the markets of today, however, the stock market described by Proudhon appears embryonic. Neverthele...

  16. IN MEMORIAM Joseph M Marshall (6 September 1943-15 December 2008)

    Science.gov (United States)

    2010-11-01

    Joseph M Marshall Joseph M Marshall graduated as BSc Hons. Physics, Sheffield, UK in 1965 and got a PhD degree in Edinburgh in 1970. In the same year he became Research Fellow in the University of Edinburgh, UK, then Lecturer (1974), Senior Lecturer (1981) and Reader (1984) in the University of Abertay Dundee. In 1987 he took the position of Professor of Electronic Materials in the University of Wales Swansea, UK and in 2002 became Emeritus Professor in the same University. His scientific papers (over 180) span three areas: Experimental and theoretical studies of the conductive, photoconductive and other properties of crystalline, polycrystalline, amorphous and organic semiconductors; Computer based numerical modelling of carrier transport and other properties of semiconducting materials and electronic devices; Design, fabrication and characterisation of thin-film sensor devices and systems, for applications in information technology, medicine, automotive industry, etc. He was Member of the Organising Committee of the annual Chelsea Conferences on Amorphous and Liquid Semiconductors (London, UK), Scientific Chairman of the Organising Committee of the 1990-2008 Biennial International Schools on Condensed Matter Physics (Varna, Bulgaria), Finance Chairman of the 1993 International Conference on Amorphous Semiconductors (Cambridge, UK), Co-Director of the 2001 NATO Advanced Study Institute 'Photovoltaic and Photoactive Materials - Properties, Technology and Applications' (Sozopol, Bulgaria) and co-editor of their Proceedings. He was a recipient of the Marin Drinov Medal of the Bulgarian Academy of Sciences (1998) and the Georgi Nadjakov Sign of Honour of the Institute of Solid State Physics (2005).

  17. Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.

    Science.gov (United States)

    Nascimento-Ferreira, Isabel; Nóbrega, Clévio; Vasconcelos-Ferreira, Ana; Onofre, Isabel; Albuquerque, David; Aveleira, Célia; Hirai, Hirokazu; Déglon, Nicole; Pereira de Almeida, Luís

    2013-07-01

    Machado-Joseph disease or spinocerebellar ataxia type 3, the most common dominantly-inherited spinocerebellar ataxia, results from translation of the polyglutamine-expanded and aggregation prone ataxin 3 protein. Clinical manifestations include cerebellar ataxia and pyramidal signs and there is no therapy to delay disease progression. Beclin 1, an autophagy-related protein and essential gene for cell survival, is decreased in several neurodegenerative disorders. This study aimed at evaluating if lentiviral-mediated beclin 1 overexpression would rescue motor and neuropathological impairments when administered to pre- and post-symptomatic lentiviral-based and transgenic mouse models of Machado-Joseph disease. Beclin 1-mediated significant improvements in motor coordination, balance and gait with beclin 1-treated mice equilibrating longer periods in the Rotarod and presenting longer and narrower footprints. Furthermore, in agreement with the improvements observed in motor function beclin 1 overexpression prevented neuronal dysfunction and neurodegeneration, decreasing formation of polyglutamine-expanded aggregates, preserving Purkinje cell arborization and immunoreactivity for neuronal markers. These data show that overexpression of beclin 1 in the mouse cerebellum is able to rescue and hinder the progression of motor deficits when administered to pre- and post-symptomatic stages of the disease.

  18. Dystonia in Machado-Joseph disease: Clinical profile, therapy and anatomical basis.

    Science.gov (United States)

    Nunes, Marcelo B; Martinez, Alberto Rolim M; Rezende, Thiago Junqueira R; Friedman, Joseph H; Lopes-Cendes, Iscia; D'Abreu, Anelyssa; França, Marcondes C

    2015-12-01

    Dystonia is frequent in Machado-Joseph disease, but several important aspects are not yet defined, such as the detailed clinical profile, response to treatment and anatomical substrate. We screened 75 consecutive patients and identified those with dystonia. The Burke-Marsden-Fahn Dystonia Rating Scale was employed to quantify dystonia severity. Patients with dystonia received levodopa 600 mg/day for 2 months and were videotaped before and after treatment. A blinded evaluator rated dystonia in the videos. Patients with disabling dystonia who failed to respond to levodopa treatment received botulinum toxin. Finally, volumetric T1 and diffusion tensor imaging sequences were obtained in the dystonic group using a 3T-MRI scanner to identify areas of gray and white matter that were selectively damaged. There were 21 patients with dystonia (28%): 9 classified as generalized and 12 as focal/segmental. Patients with dystonia had earlier onset and larger (CAG) expansions (28.9 ± 11.7 vs 40.6 ± 11.4; p Machado-Joseph disease is frequent and often disabling, but may respond to levodopa. It is associated predominantly with structural abnormalities around the motor cortices and in the thalami. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Iterative CT reconstruction with small pixel size: distance-driven forward projector versus Joseph's

    Science.gov (United States)

    Hahn, K.; Rassner, U.; Davidson, H. C.; Schöndube, H.; Stierstorfer, K.; Hornegger, J.; Noo, F.

    2015-03-01

    Over the last few years, iterative reconstruction methods have become an important research topic in x-ray CT imaging. This effort is motivated by increasing evidence that such methods may enable significant savings in terms of dose imparted to the patient. Conceptually, iterative reconstruction methods involve two important ingredients: the statistical model, which includes the forward projector, and a priori information in the image domain, which is expressed using a regularizer. Most often, the image pixel size is chosen to be equal (or close) to the detector pixel size (at field-of-view center). However, there are applications for which a smaller pixel size is desired. In this investigation, we focus on reconstruction with a pixel size that is twice smaller than the detector pixel size. Using such a small pixel size implies a large increase in computational effort when using the distance-driven method for forward projection, which models the detector size. On the other hand, the more efficient method of Joseph will create imbalances in the reconstruction of each pixel, in the sense that there will be large differences in the way each projection contributes to the pixels. The purpose of this work is to evaluate the impact of these imbalances on image quality in comparison with utilization of the distance-driven method. The evaluation involves computational effort, bias and noise metrics, and LROC analysis using human observers. The results show that Joseph's method largely remains attractive.

  20. Great Names in the History of Orthopaedics XIV: Joseph Lister (1827–1912 Part 1

    Directory of Open Access Journals (Sweden)

    Fu Kuo-Tai Louis

    2010-12-01

    Full Text Available Although the evolution of surgical practices cannot be the efforts of a single individual, Joseph almost single-handedly revolutionised modern surgery. Undoubtedly one of the greatest surgical benefactors of mankind, Joseph Lister was as great a scientist as he was a surgeon. His earliest research after graduation was on the muscles of the iris and coagulation of blood. He was one of the pioneers in bacteriology and the first to isolate bacteria in pure culture. While Professor of Surgery at Glasgow, he appreciated the significance of the antiseptic properties of certain phenolic compounds and applied them in clinical surgery. Although he was not the first person to apply antisepsis in surgery, he was the one who established the principles of antiseptic and later aseptic surgery and convinced the medical profession of his principles. In the world of science, credit goes to the person who developed and propagated the discovery, it first. Indeed, surgery is divided into its pre- and post-Listerian eras.

  1. Presenting Digital Archives with Historical GIS: Mapping Joseph Needham's Trips in WWII China

    Science.gov (United States)

    Wu, H.

    2017-12-01

    Since 2016, select groups of students (aged 14-17) from the Independent School Foundation Academy (ISF), Hong Kong, have been constructing a Historical GIS system for the Needham Research Institute (NRI), Cambridge, UK, during their annual summer school in Cambridge. Students read the diaries and reports of Joseph Needham, the Cambridge scientist who worked in China from 1943 to 1946 as the head of the Sino-British Science Cooperation Office, and mapped out both Needham's itineraries and the location of Chinese scientific institutions he visited. By taking part in this project, students learnt two sets of skills: the historian's skills of reading and analyzing primary sources, and the geographer's skills of creating datasets and maps with a GIS software. This project will be carried on in future years, to gradually include other trips Joseph Needham undertook in China in the second half of the 20th century, thus making an essential contribution to the digitalization and the diffusion of the NRI's archives. As a historical researcher in NRI and an educator, the presenter will offer some reflections on the benefit of historical GIS projects as a venue par excellence for research institutions and schools to join force, enhancing both academic research and teaching with an enlarged social impact.

  2. The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection.

    Science.gov (United States)

    Koob, George F

    2017-04-01

    W. Horsley Gantt and Joseph V. Brady laid a rich foundation for understanding the concept of emotion, derived from 2 prominent traditions of physiology and psychology: classic conditioning and operant conditioning, respectively. This framework guided my fierce interest in motivation in general and the interaction between reward and stress, which began at John Hopkins with my thesis work under the guidance of Drs. Zoltan Annau, Solomon Synder, and Joseph Brady, among many others. Using the study of the neurobiology of addiction as a framework, I argue that drug addiction not only involves positive reinforcement associated with the rewarding effects of drugs of abuse but also involves another major source of reinforcement, specifically negative reinforcement driven by negative emotional states (termed the "dark side" of addiction). Excessive activation of the brain reward systems leads to antireward or a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of the brain stress systems, both of which may be neurobiologically linked. Understanding the neuroplasticity of the neurocircuitry that comprises the negative reinforcement associated with addiction is a key to understanding negative emotional states in general and their pathophysiology.

  3. Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.

    Science.gov (United States)

    Nóbrega, Clévio; Carmo-Silva, Sara; Albuquerque, David; Vasconcelos-Ferreira, Ana; Vijayakumar, Udaya-Geetha; Mendonça, Liliana; Hirai, Hirokazu; de Almeida, Luís Pereira

    2015-12-01

    Machado-Joseph disease is a progressive neurodegenerative disorder associated with the polyQ-expanded ataxin-3 (encoded by ATXN3), for which no therapy is available. With the aim of clarifying the mechanism of neurodegeneration, we hypothesized that the abnormally long polyQ tract would interact aberrantly with ataxin-2 (encoded by ATXN2), another polyQ protein whose function has recently been linked to translational regulation. Using patient's samples and cellular and animal's models we found that in Machado-Joseph disease: (i) ataxin-2 levels are reduced; and (ii) its subcellular localization is changed towards the nucleus. Restoring ataxin-2 levels by lentiviral-mediated overexpression: (i) reduced mutant ataxin-3 levels; and (ii) rescued behaviour defects and neuropathology in a transgenic mouse model of Machado-Joseph disease. Conversely (i) mutating the ataxin-2 motif that enables binding to its natural interactor and translation activator poly(A)-binding protein; or (ii) overexpressing poly(A)-binding protein, had opposite effects, increasing mutant ataxin-3 translation and aggregation. This work suggests that in Machado-Joseph disease, mutant ataxin-3 drives an abnormal reduction of ataxin-2 levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 and other proteins and aggravates Machado-Joseph disease. Re-establishment of ataxin-2 levels reduces mutant ataxin-3 and alleviates Machado-Joseph disease pathogenesis opening a new avenue for therapeutic intervention in this and potentially other polyQ disorders. © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. Agricultural land use and water quality in the upper St. Joseph River basin, Michigan

    Science.gov (United States)

    Cummings, T. Ray

    1978-01-01

    Land use in the upper St. Joseph River basin of south-central Michigan is primarily agricultural. In the 144-square-mile area, the chemical and physical characteristics of water are determined by the climate and soils, as well as by land conservation practices. Municipal waste discharges affect water quality at some locations, as do the larger lakes and ponds. Data indicate that mean discharge from the basin is 135 cubic feet per second. About half this flow is contributed to the St. Joseph River by three major tributaries: Beebe Creek (36 cubic feet per second); Sand Creek (24 cubic feet per second); and Soap Creek (13 cubic feet per second). Runoff from 21 drainage areas delineated for the investigation ranged from 0.22 to 4.07 cubic feet per second per square mile; both the higher and lower values are largely the result of naturally occurring inter- and intrabasin transfers of water.Suspended-sediment concentrations are low throughout the basin, rarely exceeding 100 milligrams per liter. Mean concentrations at four daily sampling stations on the major tributaries and on the St. Joseph River ranged from 9.7 milligrams per liter to 38 milligrams per liter. The maximum sediment yield was 182 pounds per acre per year. Deposition of sediment in five of the 21 areas resulted in a net loss of sediment transported, and thus “negative” yields.Nitrogen and phosphorus concentrations do not vary greatly from site to site. Mean concentrations of total nitrogen at downstream sites on Beebe, Sand, and Soap Creeks, and on the St. Joseph River ranged from 1.5 to 1.8 milligrams per liter. About 90 percent of all nitrogen, and 66 percent of all phosphorus, is transported in solution. Land used principally for agriculture has a mean total nitrogen yield of 4.9 pounds per acre per year and a mean total phosphorus yield of 0.13 pounds per year. A comparison of total nitrogen and total phosphorus yields with type of agricultural use showed few relationships; nitrogen yield

  5. Recreating Religion: The Response to Joseph Smith’s Innovations in the Second Prophetic Generation of Mormonism

    OpenAIRE

    Blythe, Christopher James

    2011-01-01

    On June 27, 1844, Joseph Smith, the founder of The Church of Jesus Christ ofLatter-day Saints, was assassinated. In the wake of his death, a number of would-besuccessors emerged. Each of these leaders - part of what I call the second propheticgeneration - established a unique vision of Mormonism. In 1844, Mormonism was in the middle of a major shift in its character. JosephSmith’s death left numerous theological and practical questions unresolved. This thesis argues that, rather than merel...

  6. Sustainable Planning Practices in St. Joseph Watershed as a Mixed Land-Use Watershed to Reduce the Risk of Chemical Impairment of Surface Water Supplies

    Science.gov (United States)

    Increased population growth in St. Joseph Watershed and the mix of land-use with urban and agricultural production brings about chemical impairment of metropolitan drinking water supplies. Furthermore, the St. Joseph Watershed is not only a drinking water supply, but also it provides water for recre...

  7. Aspects sociaux et religieux dans l’anthropologie pédagogique de Joseph Wresinski (Social and religious aspects in Joseph Wresinski’s pedagogical anthropology

    Directory of Open Access Journals (Sweden)

    Gabriella Kiss

    2016-12-01

    Full Text Available Joseph Wresinski founded the ATD-Fourth World Movement in France in 1957 with the aim of eradicating poverty, as well as the exclusion and the lack of rights that go with it, in order to be able to model the structure of a society that has the most disadvantaged people in its centre. As an ordained priest of the Catholic Church, he created a secular organisation whose practice and ensuing principles are shaped by this peculiar duality. In order to demonstrate this facet, the first part of the present study gives a brief overview of Wresinski’s career, highlighting how the personal aspects of his life had influenced his views concerning the poorest, and more specifically, the principles and objectives of the Movement he founded. Thereafter, I address the particularities of the Movement, emphasizing its religious and social dimensions, in relation to the secular nature of French society. The two subchapters of the third part describe the two factors of the primordial relationship that constitutes the two, interdependent pillars of the Movement, emphasizing the relevant features of Wresinski’s vision concerning the poorest and also the volunteers engaged in the Movement. Finally, I intend to show how the pedagogical anthropology of Wresinski, with his radical interpretation of the Gospel, positions in its centre the man who, disfigured by poverty, is still the most authentic bearer of universal humanity, as he inseparably incorporates human rights and the divine filiation.

  8. Using 3D acoustic telemetry to assess the response of resident salmonids to strobe lights in Lake Roosevelt, Washington: Chief Joseph Kokanee Enhancement Feasibility Study, 2001-2002 annual report

    Science.gov (United States)

    Perry, R.W.; Farley, M.J.; Hansen, G.S.; Shurtleff, D.J.; Rondorf, D.W.; LeCaire, R.

    2003-01-01

    In 1995, the Chief Joseph Kokanee Enhancement Project was established to mitigate the loss of anadromous fish due to the construction of Chief Joseph and Grand Coulee dams. The objectives of the Chief Joseph Enhancement Project are to determine the status of resident kokanee (Oncorhynchus nerka) populations above Chief Joseph and Grand Coulee dams and to enhance kokanee and rainbow trout (Oncorhynchus mykiss) populations. Studies conducted at Grand Coulee Dam documented substantial entrainment of kokanee through turbines at the third powerhouse.

  9. RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease.

    Science.gov (United States)

    Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Déglon, Nicole; de Almeida, Luís Pereira

    2014-01-01

    Machado-Joseph disease or Spinocerebellar ataxia type 3 is a progressive fatal neurodegenerative disorder caused by the polyglutamine-expanded protein ataxin-3. Recent studies demonstrate that RNA interference is a promising approach for the treatment of Machado-Joseph disease. However, whether gene silencing at an early time-point is able to prevent the appearance of motor behavior deficits typical of the disease when initiated before onset of the disease had not been explored. Here, using a lentiviral-mediated allele-specific silencing of mutant ataxin-3 in an early pre-symptomatic cerebellar mouse model of Machado-Joseph disease we show that this strategy hampers the development of the motor and neuropathological phenotypic characteristics of the disease. At the histological level, the RNA-specific silencing of mutant ataxin-3 decreased formation of mutant ataxin-3 aggregates, preserved Purkinje cell morphology and expression of neuronal markers while reducing cell death. Importantly, gene silencing prevented the development of impairments in balance, motor coordination, gait and hyperactivity observed in control mice. These data support the therapeutic potential of RNA interference for Machado-Joseph disease and constitute a proof of principle of the beneficial effects of early allele-specific silencing for therapy of this disease.

  10. Handwerklicher Hintergrund und Perspektiven akademischer Studien. Zum Frühwerk Joseph Führichs in Böhmen

    Czech Academy of Sciences Publication Activity Database

    Machalíková, Pavla

    -, 0077 (2013), s. 1-34 ISSN 2190-3328 Institutional support: RVO:68378033 Keywords : Josef Führich * painting, Bohemia 19th century * religious patriotic painting Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.riha- journal .org/articles/2013/2013-oct-dec/machalikova-joseph-fuehrich

  11. Defining American Heroes: Analyzing the Metamorphosis of the War Hero in Twentieth Century War Films Using Joseph Campbell's, "Hero's Journey."

    Science.gov (United States)

    Frith, Luci A.

    In "The Hero's Journey" Joseph Campbell identifies the patterns that inform the myths of the "hero" throughout recorded history. By using Campbell's template, this paper examines how the American war hero is portrayed and has been portrayed in film. The paper states that Americans not only define their war heroes in films but…

  12. Laparoscopic Scar: a mimicker of Sister Mary Joseph's nodule on positron emission tomography/CT

    International Nuclear Information System (INIS)

    Setty, B.; Blake, M.A.; Holalkere, N.S.; Blaszkowsky, L.S.; Fischman, A.

    2006-01-01

    Positron emission tomography/CT is an established imaging method in the diagnosis and staging of cancers. 18 F -fluoro-2-deoxy-D-glucose (FDG) is the most commonly used radiotracer in positron emission tomography/CT. It is a tumour viability agent and usually its uptake within a lesion reflects the presence of a viable tumour tissue. However, false-positive FDG uptake is known to occur in benign processes of either inflammatory or infectious aetiology. We describe FDG uptake at the site of laparoscopic scar that mimicked Sister Mary Joseph's nodule in a patient with gastric adenocarcinoma. Here, the knowledge of the patient's history and subtle imaging findings helped in accurate staging of the patient. In this case report, we emphasize the value of the knowledge of the patient history and awareness of different pitfalls of FDG to achieve a correct diagnosis on positron emission tomography/CT

  13. Joseph Swan (1791-1874): pioneer of research on peripheral nerves.

    Science.gov (United States)

    Barton, N J; Smith, B D

    2008-06-01

    Joseph Swan was born in 1791 and appointed surgeon to Lincoln County Hospital in 1814. In addition to his clinical work, he carried out what were probably the first animal experiments on nerve injuries. These were mostly on rabbits, in which the sciatic nerves were partly or wholly divided, had a section excised, or were ligated. He found that regeneration could occur, even after neurectomy. He reported these results, together with his experience in human patients and the effects of neurectomy in a horse, in an essay of 1819, which won the Jacksonian Prize of the Royal College of Surgeons of England and is still preserved there. In 1827 he moved to London, where he devoted himself mainly to dissections of the nervous system and was active in the College. He retired to Filey in Yorkshire, where he died in 1874.

  14. Catherine the Great in the writings of Charles-Joseph Lamoral, 7th Prince de Ligne

    Directory of Open Access Journals (Sweden)

    Joanna Pychowska

    2012-01-01

    Full Text Available Charles-Joseph de Ligne (1735-1814, a Wallon and European Prince, subject of the Austro-Hungary Empire, a heartbreaker of the French Europe, is considered the most famous representative of literary cosmopolitanism. War, love and writing were inseparable in his life. He took part in numerous military campaigns, serving both Austria and Russia, as a Russian colonel, a commander of the order of Maria Theresa, and an Austrian fi eld marshal. He authored various texts related to war; he admired heroism of Charles II, Conde, the tactics of Frederick II, the strategies of Napoleon, Catherine II. The latter was immportalized in de Ligne’s various texts representing different literary genres. The Prince was clearly fascinated by the Empress, and he depicted her in a positive light as an educated person, both agreable and determined. Can we, however, talk about the documentary character of his work ? Instead, the Prince seems to be a documentalist-interpreter.

  15. The making of a career: Joseph Toynbee's first steps in otology.

    Science.gov (United States)

    Mudry, A

    2012-01-01

    Joseph Toynbee (1815-1866) is considered one of the fathers of modern otology. He spent his whole life in London, studying and describing the anatomy and pathology of the main diseases of the ear. This paper presents some of the motivations behind Toynbee's decision to specialise in otology, by examining several of his letters published under the signature 'J. T.' in The Lancet between 1838 and 1839. Frustrated by the weakened state of aural surgery in Britain, and by the popularity of several 'quacks aurists' (including John Harrison Curtis, William Wright and Alexander Turnbull), Toynbee insisted that the study of the ear needed to distance itself from quackery and rebuild itself upon a scientific foundation. This paper evaluates several exchanges between Toynbee and Curtis, Wright and Turnbull.

  16. Anthropological neurology: symptoms and their meanings according to Joseph Prick (1909-1978).

    Science.gov (United States)

    ter Meulen, B C; Dekkers, W J M; Keyser, A; van Woerkom, T C A M

    2011-01-01

    This article describes the life and work of the Dutch neurologist Joseph Prick (1909-1978) and his idea of an anthropological neurology. According to Prick, neurological symptoms should not only be explained from an underlying physico-chemical substrate but also be regarded as meaningful. We present an outline of the historical and philosophical context of his ideas with a focus on the theory of the human body by the French philosopher Maurice Merleau-Ponty (1908-1961) and the concept of anthropology-based medicine developed by Frederik Buytendijk (1887-1974). We give an overview of anthropological neurology as a clinical practice and finally we discuss the value of Prick's approach for clinical neurology today.

  17. Limitations of the Historical-Critical Method According to Joseph Ratzinger (Benedict XVI

    Directory of Open Access Journals (Sweden)

    Sławomir Zatwardnicki

    2016-08-01

    Full Text Available According to Joseph Ratzinger the appearance of the historical-critical method simultaneously gave rise to the struggle for its scope and character. This method is an indispensable tool of exegetic craft, but it has its limitations as well. It’s shortcomings of the historical-critical method that are presented and discussed one by one in the article, and they are the following: looking only for historical meaning of the text; pointing only to one dimension (the human one of Holy Scriptures; lack of continuity as one of principles of the method; outcomes of the research being hypothetical. At the end of the article a dangerous discord between scientific research and study of theological meaning of texts is highlighted. Benedict XVI’s appeal to reinstate theological principles mentioned in the Dogmatic Constitution Dei Verbum and to link them with scientific principles was reminded of as well.

  18. Acquisition of wood fuel at the Joseph C. McNeil Generating Station

    Energy Technology Data Exchange (ETDEWEB)

    Kropelin, W. [Burlington Electric Dept., VT (United States)

    1993-12-31

    The Joseph C. McNeil Generating Station is the world`s largest single boiler, municipally-owned, wood-fired electrical generating plant. The 50 megawatt McNeil Station is located in Burlington, Vermont and is owned by several Vermont public and private electric utilities. The operator and majority owner is the City of Burlington Electric Department (BED). Wood fuel procurement for the McNeil Station has been conducted in an environmentally sensitive way. Harvesting is carried out in conformance with a comprehensive wood chip harvesting policy and monitored by professional foresters. Unpredictable levels of Station operation require rigid adherence to a wood storage plan that minimizes the risk of over heating and spontaneous combustion of stockpiled fuel.

  19. Sympathetic science: Charles Darwin, Joseph Hooker, and the passions of Victorian naturalists.

    Science.gov (United States)

    Endersby, Jim

    2009-01-01

    This essay examines the complex tangle of emotional and scientific attachments that linked Darwin and botanist Joseph Dalton Hooker. Analyzing their roles as husbands, fathers, and novel readers demonstrates that possessing and expressing sympathy was as important for Victorian naturalists as it was for Victorian husbands. Sympathy was a scientific skill that Victorian naturalists regarded as necessary to fully understand the living world; although sympathy became increasingly gendered as feminine over the course of the century, its importance to male naturalists requires us to rethink the ways gender roles were negotiated in Victorian Britain. Botany was, for men like Darwin and Hooker, an acceptably masculine pursuit that nevertheless allowed--and even required--them to be sensitive and sympathetic.

  20. A Science Superior to Music: Joseph Sauveur and the Estrangement between Music and Acoustics

    Science.gov (United States)

    Fix, Adam

    2015-09-01

    The scientific revolution saw a shift from the natural philosophy of music to the science of acoustics. Joseph Sauveur (1653-1716), an early pioneer in acoustics, determined that science as understood in the eighteenth century could not address the fundamental problems of music, particularly the problem of consonance. Building on Descartes, Mersenne, and Huygens especially, Sauveur drew a sharp divide between sound and music, recognizing the former as a physical phenomenon obeying mechanical and mathematical principles and the latter as an inescapably subjective and unquantifiable perception. While acoustics grew prominent in the Académie des sciences, music largely fell out of the scientific discourse, becoming primarily practiced art rather than natural philosophy. This study illuminates what was considered proper science at the dawn of the Enlightenment and why one particular branch of natural philosophy—music—did not make the cut.

  1. [Advances in Neurological Therapeutics for Friedreich Ataxia and Machado-Joseph Disease].

    Science.gov (United States)

    Yabe, Ichiro; Sasaki, Hidenao

    2017-08-01

    We reviewed advances in therapeutics for both Friedreich ataxia and Machado-Joseph disease. Various clinical trials have been carried out, mainly for Friedreich ataxia; however, the therapeutic reports from these trials have not provided much evidence for success. Some interesting clinical trials have been reported, and further developments are expected. Regenerative therapy using umbilical cord mesenchymal stem cells and a therapeutic study investigating a new pathomechanism in animal and/or cell culture studies were reported. We expect that these results will translate to therapeutic strategies for patients with these disorders. In addition, biomarkers play an important role when novel treatments are discovered and clinical trials are performed: hence at present, a number of biomarkers such as gait analysis by triaxial accelerometers and prism adaptation of hand-reaching movements, are being examined.

  2. [Effective melatonin therapy in a case of Machado-Joseph disease with insomnia].

    Science.gov (United States)

    Takei, A; Okawa, M; Sasaki, H; Hamada, T; Tashiro, K

    2000-07-01

    The effects of melatonin (MLT) therapy on insomnia and serum MLT concentration were studied in a 44-year-old man with Machado-Joseph disease. He suffered from insomia since age 41, and could not sleep well, despite that he was given many kinds of hypnotics. He showed neither noctural central apnea, inspirative stridor, restless leg syndrome, REM without atonia, nor noctural polyuria, all of which are known to cause insomnia in spinocerebellar degeneration. The peak serum level of MLT was low, 9.2 pg/ml. He was administered 9 mg of MLT p.o. at 8 p.m., and it's peak noctural level elevated to 7,000 pg/ml, and this alleviated his intractable insomnia. Our experience indicate that the MLT could be effective for insomnia in MJD which relates to low MLT concentration.

  3. Joseph Henry’s role in the discovery of electromagnetic induction

    International Nuclear Information System (INIS)

    Smith, Glenn S

    2017-01-01

    The discovery of electromagnetic induction in the early part of the 19th century is one of the greatest scientific achievements of all time, and it has had tremendous technological consequences. The credit for this discovery rightfully goes to the great English experimental physicist Michael Faraday. However, the American physicist Joseph Henry made some observations comparable to Faraday’s at nearly the same time, and for that reason, Faraday and Henry are often considered to be co-discoverers of some aspects of electromagnetic induction. We examine Henry’s early research on electromagnetism, starting from his efforts to improve the electromagnet, which led directly to his investigations of induction. We describe his earliest experiments on both mutual and self-induction, and pay particular attention to the relationship of Henry’s research to that of Faraday. The approach is one in which the experiments are described and then analysed using modern theory and terminology. (paper)

  4. Operatic films: a comparative study of Don Giovanni by Joseph Losey and Juan by Kasper Holten

    Directory of Open Access Journals (Sweden)

    Isabel VILLANUEVA BENITO

    2017-12-01

    Full Text Available From an artistic point of view, the adaptation of an opera to the cinema, traditionally has been considered a complex and controversial process. Don Giovanni, of W.A. Mozart is one of the operas that more audiovisual versions has generated during the centuries XX and XXI, although very few films have finally been taken to the screen. This paper is focused on comparing the audiovisual versions Don Giovanni, by Joseph Losey (1979, and Juan by Kasper Holten (2010. Through a quantitative and qualitative methodology based on content analysis, this research reflects on the degree of intervention exercised by the language and audiovisual format used in the process of reinterpretation of the pre-existing operatic text.

  5. Resident fish stock status above Chief Joseph and Grand Coulee dams : 2000 annual report; ANNUAL

    International Nuclear Information System (INIS)

    Lockwood, N.; McLellan, J.; Crossley, B.

    2001-01-01

    The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, commonly known as the Joint Stock Assessment Project (JSAP) is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (blocked area). The three-phase approach of this project will enhance the fisheries resources of the blocked area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information housed in a central location will allow managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP (NWPPC program measure 10.8B.26) is designed and guided jointly by fisheries managers in the blocked area and the Columbia Basin blocked area management plan (1998). The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of blocked area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the blocked area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. The use of common collection and analytical tools is essential to the process of streamlining joint management decisions. In 1999 and 2000 the project

  6. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2000 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Lockwood, Jr., Neil [Kalispel Tribe of Indians, Usk, WA (United States); McLellan, Jason G [Washington Department of Fish and Wildlife, Spokane, WA (United States); Crossley, Brian [Spokane Tribe of Indians, Department of Natural Resources, Wellpinit, WA (United States); O' Connor, Dick

    2001-01-01

    The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, commonly known as the Joint Stock Assessment Project (JSAP) is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (blocked area). The three-phase approach of this project will enhance the fisheries resources of the blocked area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information housed in a central location will allow managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP (NWPPC program measure 10.8B.26) is designed and guided jointly by fisheries managers in the blocked area and the Columbia Basin blocked area management plan (1998). The initial year of the project (1997) identified the need for a central data storage and analysis facility, coordination with the StreamNet project, compilation of blocked area fisheries information, and a report on the ecological condition of the Spokane River System. These needs were addressed in 1998 by acquiring a central location with a data storage and analysis system, coordinating a pilot project with StreamNet, compiling fisheries distribution data throughout the blocked area, identifying data gaps based on compiled information, and researching the ecological condition of the Spokane River. In order to ensure that any additional information collected throughout the life of this project will be easily stored and manipulated by the central storage facility, it was necessary to develop standardized methodologies between the JSAP fisheries managers. The use of common collection and analytical tools is essential to the process of streamlining joint management decisions. In 1999 and 2000 the project

  7. ‘Dutchman, lazier than any other race of mankind’. Joseph Banks bezoekt de Nederlandse Republiek (1773

    Directory of Open Access Journals (Sweden)

    Renée Schilling

    2015-10-01

    Full Text Available ‘Dutchman, Lazier than any other race of mankind’: Joseph Banks in the Dutch Republic.In 1773, the British scientist and explorer Joseph Banks (1743-1820 visited the Dutch Republic for a short holiday. By request of his sister Sarah, Banks kept a journal in which he wrote about his experiences in the Republic. These descriptions are remarkably negative about the Dutch, their culture and their scientific knowledge. It also gives a good insight in Banks’s personality. This article tries to answer the question why Banks is having such a bad time in the Dutch Republic. The article contains a short summary of the journal, an account of Banks’s earlier journey to Batavia with James Cook and a comparative analysis of other British travel accounts of the Dutch Republic in the eighteenth century.

  8. Review: Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa (2013)

    OpenAIRE

    Reinhart Kößler

    2015-01-01

    Review of the monograph:Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa, Potsdam: Potsdam University Press, 2013, ISBN 9783869562483, 300 pp.

  9. THE INNOVATION THEORY OF JOSEPH SCHUMPETER: FROM THE CLASSICAL DEFINITION OF THE TERM “INNOVATION” UP TO THE MODERN UNDERSTANDING OF THE INNOVATION IDEAS

    Directory of Open Access Journals (Sweden)

    A. Masliukivska

    2013-03-01

    Full Text Available The paper studies the evolution of the appearance of the term “innovation” and its classical definition. The study exposes the main provisions of innovation theory of Joseph Schumpeter and their modern understanding.

  10. THE INNOVATION THEORY OF JOSEPH SCHUMPETER: FROM THE CLASSICAL DEFINITION OF THE TERM “INNOVATION” UP TO THE MODERN UNDERSTANDING OF THE INNOVATION IDEAS

    OpenAIRE

    A. Masliukivska

    2013-01-01

    The paper studies the evolution of the appearance of the term “innovation” and its classical definition. The study exposes the main provisions of innovation theory of Joseph Schumpeter and their modern understanding.

  11. Euroopal jätkub väljakutseid ka peale laienemist / Joseph Daul ; interv. Kaja Sõrg

    Index Scriptorium Estoniae

    Daul, Joseph

    2008-01-01

    Euroopa Parlamendi Euroopa Rahvapartei ja Euroopa Demokraatide fraktsiooni esimees Joseph Daul vastab küsimustele, mis puudutavad fraktsiooni järgnevate aastate prioriteete, fraktsiooni peamisi saavutusi käesoleva koosseisu ajal, Euroopa ühise põllumajanduspoliitika tulevikku, fraktsioonikaaslase Tunne Kelami osalust fraktsiooni töös ning Euroopa Parlamendi ametliku asukoha võimalikku viimist Strasbourg'ist Brüsselisse

  12. The works of Joseph and Michael Haydn in Ondřej Horník's collection

    Czech Academy of Sciences Publication Activity Database

    Freemanová, Michaela

    2017-01-01

    Roč. 9, 1-2 (2017), s. 14-23 ISSN 1803-7828 Institutional support: RVO:68378076 Keywords : music manuscripts * Joseph Haydn * Michael Haydn * Ondřej Horník's collection * church music Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Performing arts studies ( Music ology, Theater science, Dramaturgy) http://www.nm.cz/publikace/archiv.php?id=16

  13. Review: Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa (2013)

    OpenAIRE

    Reinhart Kößler; Arnold-Bergstraesser-Institut

    2015-01-01

    Review of the monograph:Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa, Potsdam: Potsdam University Press, 2013, ISBN 9783869562483, 300 pp. Besprechung der Monographie:Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa, Potsdam: Potsdam University Press...

  14. War, sanity, and the Nazi mind: the last passion of Joseph Jastrow.

    Science.gov (United States)

    Behrens, Peter J

    2009-11-01

    The career of Joseph Jastrow (1863-1944) spanned more than 50 years in service to psychology. For 40 years he represented academic psychology at the University of Wisconsin as chair of the psychology department (1886 to 1927), but also was never far from popularizing psychology through books, articles, public lectures, newspaper columns, and finally radio lectures (e.g., Jastrow, 1900, 1935b). Providing a scientific and progressive psychology for the general public was always a strong penchant for Jastrow on several subjects, such as spiritualism (Jastrow, 1911) and effective living (Jastrow, 1935b). About 1939, while he was well into his 70s, his efforts focused on exposing the menace that Adolf Hitler and Nazism posed, so he undertook to enlist prominent editors to publish his work, Hitler: Mask and Myth, as articles or a book. He was not successful in gaining support for the project. His failing can be understood from the perspectives of the American market for Hitler material, the shortcomings of the manuscript, and how he represented psychology to the American public.

  15. Toward RNAi therapy for the polyglutamine disease Machado-Joseph disease.

    Science.gov (United States)

    Costa, Maria do Carmo; Luna-Cancalon, Katiuska; Fischer, Svetlana; Ashraf, Naila S; Ouyang, Michelle; Dharia, Rahil M; Martin-Fishman, Lucas; Yang, Yemen; Shakkottai, Vikram G; Davidson, Beverly L; Rodríguez-Lebrón, Edgardo; Paulson, Henry L

    2013-10-01

    Machado-Joseph disease (MJD) is a dominantly inherited ataxia caused by a polyglutamine-coding expansion in the ATXN3 gene. Suppressing expression of the toxic gene product represents a promising approach to therapy for MJD and other polyglutamine diseases. We performed an extended therapeutic trial of RNA interference (RNAi) targeting ATXN3 in a mouse model expressing the full human disease gene and recapitulating key disease features. Adeno-associated virus (AAV) encoding a microRNA (miRNA)-like molecule, miRATXN3, was delivered bilaterally into the cerebellum of 6- to 8-week-old MJD mice, which were then followed up to end-stage disease to assess the safety and efficacy of anti-ATXN3 RNAi. Despite effective, lifelong suppression of ATXN3 in the cerebellum and the apparent safety of miRATXN3, motor impairment was not ameliorated in treated MJD mice and survival was not prolonged. These results with an otherwise effective RNAi agent suggest that targeting a large extent of the cerebellum alone may not be sufficient for effective human therapy. Artificial miRNAs or other nucleotide-based suppression strategies targeting ATXN3 more widely in the brain should be considered in future preclinical tests.

  16. Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.

    Science.gov (United States)

    Esteves, Sofia; Duarte-Silva, Sara; Naia, Luana; Neves-Carvalho, Andreia; Teixeira-Castro, Andreia; Rego, Ana Cristina; Silva-Fernandes, Anabela; Maciel, Patrícia

    2015-01-01

    Machado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which currently lacks effective treatment. In this work we tested the therapeutic efficacy of chronic treatment with valproic acid (VPA) (200mg/kg), a compound with known neuroprotection activity, and previously shown to be effective in cell, fly and nematode models of MJD. We show that chronic VPA treatment in the CMVMJD135 mouse model had limited effects in the motor deficits of these mice, seen mostly at late stages in the motor swimming, beam walk, rotarod and spontaneous locomotor activity tests, and did not modify the ATXN3 inclusion load and astrogliosis in affected brain regions. However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects, confirming target engagement. In spite of limited results, the use of another dosage of VPA or of VPA in a combined therapy with molecules targeting other pathways, cannot be excluded as potential strategies for MJD therapeutics.

  17. Joseph John Thomson's models of matter and radiation in the early 1890s.

    Science.gov (United States)

    Bordoni, Stefano

    In the late nineteenth century, Joseph John Thomson moved away from Maxwell's specific theoretical models of matter and energy, even though he continued to rely on the general framework of Maxwell's electromagnetic theory. In his 1893 book, he accomplished the conceptual drift towards a discrete model for matter, electricity, and fields. In Thomson's model, energy was linked to tubes of force, in particular to the aether contained in them and surrounding them: the energy was the kinetic energy of aether, of both a rotational and translational kind. Starting from Maxwell's electromagnetic fields, namely stresses propagating through a continuous solid medium, Thomson arrived at a representation of fields as a sea of discrete units carrying energy and momentum. He tried to transform Maxwell's theory into a unified picture in which atomic models of matter stood beside atomic models of fields. In 1904 his interpretation of X-rays was based on the integration between two complementary features of electromagnetic radiation, the continuity and the discreteness, and on some kind of fibrous aether. In recent secondary literature, the problematic conceptual link between J. J. Thomson's theory and contemporary theories on electromagnetic radiation has been underestimated. On the contrary, in the first half of the twentieth century, some physicists inquired into that link, and a widespread debate emerged, misunderstandings included.

  18. Joseph Carpue's file drawer experiment – A murder mystery from 1801

    Directory of Open Access Journals (Sweden)

    M. Felix Freshwater

    2015-12-01

    Full Text Available Today unpublished or “file drawer” experiments are the impetus for trial registration and reporting of all results. In 1801, Joseph Carpue, the father of modern plastic surgery, did a file drawer experiment for Benjamin West, who was President of the Royal Academy of Arts. George III had commissioned West to create the largest stained glass window ever created whose theme, the Crucifixion, was based upon Michelangelo's drawing. Subsequently, West suffered a series of political, professional and economic setbacks. In the summer of 1801, West's project was delayed. By the fall, West hoped that independent scientific confirmation of his design could salvage the project. West approached Carpue who obtained a murderer's fresh corpse that he crucified and documented the results with plaster casts created by sculptor Thomas Banks. Carpue's experiment showed that West's window design wrongly depicted the Crucifixion because West had posed the hands and shoulders incorrectly. West died in 1820 without ever being associated with Carpue's experiment. Carpue's obituary in The Lancet in 1846 contained Carpue's handwritten note that described the experiment but not West's Royal commission. As no records or publications associate the cast with West project, this can be considered to be a file drawer experiment. After 1801, West made further drawings of the Crucifixion that showed the figures in the same position as the cast. Nineteenth century auction catalogues suggest that West made a corrected Crucifixion painting, but its current location remains a mystery.

  19. Brain stem and cerebellum volumetric analysis of Machado Joseph disease patients

    Directory of Open Access Journals (Sweden)

    S T Camargos

    2011-01-01

    Full Text Available Machado-Joseph disease, or spinocerebellar ataxia type 3(MJD/SCA3, is the most frequent late onset spinocerebellar ataxia and results from a CAG repeat expansion in the ataxin-3 gene. Previous studies have found correlation between atrophy of cerebellum and brainstem with age and CAG repeats, although no such correlation has been found with disease duration and clinical manifestations. In this study we test the hypothesis that atrophy of cerebellum and brainstem in MJD/SCA3 is related to clinical severity, disease duration and CAG repeat length as well as to other variables such as age and ICARS (International Cooperative Ataxia Rating Scale. Whole brain high resolution MRI and volumetric measurement with cranial volume normalization were obtained from 15 MJD/SCA3 patients and 15 normal, age and sex-matchedcontrols. We applied ICARS and compared the score with volumes and CAG number, disease duration and age. We found significant correlation of both brain stem and cerebellar atrophy with CAG repeat length, age, disease duration and degree of disability. The Spearman rank correlation was stronger with volumetric reduction of the cerebellum than with brain stem. Our data allow us to conclude that volumetric analysis might reveal progressive degeneration after disease onset, which in turn is linked to both age and number of CAG repeat expansions in SCA 3.

  20. NREM-related parasomnias in Machado-Joseph disease: clinical and polysomnographic evaluation.

    Science.gov (United States)

    Silva, Giselle Melo Fontes; Pedroso, José Luiz; Dos Santos, Diogo Fernandes; Braga-Neto, Pedro; Do Prado, Lucila Bizari Fernandes; De Carvalho, Luciane Bizari Coin; Barsottini, Orlando G P; Do Prado, Gilmar Fernandes

    2016-02-01

    Spinocerebellar ataxias (SCA) are autosomal dominant neurodegenerative disorders that affect the cerebellum and its connections, and have a marked clinical and genetic variability. Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3)--MJD/SCA3--is the most common SCA worldwide. MJD/SCA3 is characterized classically by progressive ataxia and variable other motor and non-motor symptoms. Sleep disorders are common, and include rapid eye movement (REM) sleep behaviour disorder (RBD), restless legs syndrome (RLS), insomnia, excessive daytime sleepiness, excessive fragmentary myoclonus and sleep apnea. This study aims to focus upon determining the presence or not of non-REM (NREM)-related parasomnias in MJD/SCA 3, using data from polysomnography (PSG) and clinical evaluation. Forty-seven patients with clinical and genetic diagnosis of MJD/SCA3 and 47 control subjects were evaluated clinically and by polysomnography. MJD/SCA3 patients had a higher frequency of arousals from slow wave sleep (P sleep terrors, P = 0.001; RBD, P sleep without atonia (P sleep index (PLMSi) (P sleep (P sleep (P sleep disorders in MJD/SCA3 patients. © 2015 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.

  1. Inpatient management of borderline personality disorder at Helen Joseph Hospital, Johannesburg

    Directory of Open Access Journals (Sweden)

    Laila Paruk

    2016-06-01

    Full Text Available Objective: The aim of this report was to establish a profile of patients with borderline personality disorder (BPD admitted to the acute inpatient psychiatric assessment unit at the Helen Joseph Hospital, in Johannesburg, over the course of 1 year. Methods: A retrospective record review was conducted to investigate the prevalence, demographics, reasons for admission, treatment, length of stay and follow-up of a group of inpatients during 2010 with a diagnosis of BPD, based on DSM-IV-TR diagnostic criteria, allocated on discharge. Results: Considering evidence retrospectively, the quality of the BPD diagnosis allocated appeared adequate. Statistical analysis revealed findings mainly in keeping with other reports, for example, that patients with BPD are above-average users of resources who make significantly more use of emergency services and that they generally do not adhere well to their scheduled outpatient follow-up arrangements. The longer average length of inpatient stay of this group with BPD, however, exceeded the typically brief period generally recommended for acute inpatient containment and emergency intervention. Conclusion: Implementation of targeted prevention and early intervention strategies, based on systematised programmes such as dialectical behavioural therapy and mentalisation based therapy, may be useful in addressing these problems experienced with integrating the in- and outpatient management of BPD. Keywords: Borderline personality; inpatient; acute

  2. The institution of science and the science of institutions the legacy of Joseph Ben-David

    CERN Document Server

    2014-01-01

    The present anthology, edited by Marcel Herbst, is partially based on a conference, held in 2009, to reflect on the legacy of Ben-David, and contains a selection of substantially revised papers, plus four contributions specifically written for this volume. The book focuses on three major lines of Ben-David’s research, namely “Center and Periphery” (Part I), “Role and Ethos” (Part II), and “Organization and Growth” (Part III). In addition, comprehensive introductory (“Prologue”) and concluding chapters (“Epilogue”, Part IV) by Marcel Herbst are provided. The volume addresses the following disciplines: higher education, history and sociology of science, philosophy of science, history of medicine, public administration, policy studies, Jewish studies, and economics. The anthology is one of two new publications on Joseph Ben-David after the special Minerva edition Vol. 25, Numbers 1–2, March 1987, and Gad Freudenthal’s collection of Ben-David’s writings [1991]. The text can be used i...

  3. Visual Vertigo, Phantasmagoric Physiognomies: Joseph Roth and Walter Benjamin on the Visual Experience of Architecture

    Directory of Open Access Journals (Sweden)

    Stefan Koller

    2016-05-01

    Full Text Available This paper scrutinises Benjamin’s interest in the urban fabric of nineteenth century Paris, and compares it to contemporary writings on Paris and on (more generally new forms of urbanism in the journalistic work of Joseph Roth. It argues that both authors come to terms with the modern city through a shared set of observations and concepts, particularly the concepts of ‘expressionism’, ‘physiognomy’, and ‘phantasmagoria’. The paper clarifies how Roth and other writers in (or immediately before the 1920s developed such concepts, and how Benjamin’s The Arcades Project builds on these writers. It shows that Benjamin’s specific contribution to this body of literature is the invention of a secular mythology, with a clear application to architecture in Benjamin’s focus on the ‘boundless interiorisation’ of glass and iron construction. The paper concludes that Benjamin’s contribution to architecture is considerable when compared to the materialist orientation of his main sources in The Arcades Project (especially Boetticher and Giedion, but that the purported improvements on Benjamin’s distinguished predecessors of architectural non-materialism are by comparison less impressive.

  4. Resident Fish Stock above Chief Joseph and Grand Coulee Dams; 2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispel Department of Natural Resources, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife, Spokane, WA); Butler, Chris (Spokane Tribe of Indians, Department of Natural Resources, Wellpinit, WA)

    2003-09-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area

  5. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispell Department of Natural Resources, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife, Spokane, WA); O' Connor, Dick (Washington Department of Fish and Wildlife, Olympia, WA)

    2003-01-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power Planning Council (NPPC). The NPPC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPPC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial fish assemblages and native fish in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area and the Columbia Basin Blocked Area Management Plan

  6. Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams; 2002-2003 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispel Tribe of Indians, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife); Butler, Chris (Spokane Tribe of Indians, Wellpinit, WA)

    2006-02-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial and native fish assemblages in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The

  7. Resident Fish Stock above Chief Joseph and Grand Coulee Dams; 2003-2004 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Connor, Jason M. (Kalispel Tribe of Indians, Usk, WA); McLellan, Jason G. (Washington Department of Fish and Wildlife, Olympia, WA); Butler, Chris (Spokane Tribe of Indians, Wellpinit, WA)

    2005-11-01

    In 1980, the United States Congress enacted the Northwest Power Planning and Conservation Act (PL 96-501, 1980), which established the Northwest Power and Conservation Council (NPCC), formerly the Northwest Power Planning Council. The NPCC was directed by Congress to develop a regional Power Plan and also the Columbia River Basin Fish and Wildlife Program (FWP) to restore or replace losses of fish caused by construction and operation of hydroelectric dams in the Columbia River Basin. In developing the FWP, Congress specifically directed NPCC to solicit recommendations for measures to be included in the Program from the region's fish and wildlife agencies and Indian tribes. All measures adopted by the Council were also required to be consistent with the management objectives of the agencies and tribes [Section 4.(h)(6)(A)], the legal rights of Indian tribes in the region [Section 4.(h)(6)(D)] and be based upon and supported by the best available scientific knowledge [Section 4.(h)(6)(B)]. The Resident Fish Stock Status above Chief Joseph and Grand Coulee Dams Project, also known as the Joint Stock Assessment Project (JSAP) specifically addresses NPPC Council measure 10.8B.26 of the 1994 program. The Joint Stock Assessment Project is a management tool using ecosystem principles to manage artificial and native fish assemblages in altered environments existing in the Columbia River System above Chief Joseph and Grand Coulee Dams (Blocked Area). A three-phase approach of this project will enhance the fisheries resources of the Blocked Area by identifying data gaps, filling data gaps with research, and implementing management recommendations based on research results. The Blocked Area fisheries information is housed in a central location, allowing managers to view the entire system while making decisions, rather than basing management decisions on isolated portions of the system. The JSAP is designed and guided jointly by fisheries managers in the Blocked Area. The

  8. Spinocerebellar ataxia type 3/Machado-Joseph disease starting before adolescence.

    Science.gov (United States)

    Donis, Karina Carvalho; Saute, Jonas Alex Morales; Krum-Santos, Ana Carolina; Furtado, Gabriel Vasata; Mattos, Eduardo Preusser; Saraiva-Pereira, Maria Luiza; Torman, Vanessa Leotti; Jardim, Laura Bannach

    2016-04-01

    Onset of Machado-Joseph disease (SCA3/MJD) before adolescence has been rarely reported. This study aims to describe a cohort of SCA3/MJD with onset before 12 years of age, comparing their disease progression with the progression observed in patients with usual disease onset. We identified all cases from our cohort whose onset was before adolescence. After consent, patients were examined with clinical scales Scale for the Assessment and Rating of Ataxia (SARA) and Neurological Examination Score for Spinocerebellar Ataxia (NESSCA). Gender, age, age at onset, disease duration, CAG expanded repeats, transmitting parent, and anticipation of cases with infantile and adult onset were studied. Progression of NESSCA and SARA scores was estimated through a mixed model, and was compared with a historical group with onset after adolescence. Between 2000 and 2014, 461 symptomatic individuals from our region were diagnosed as SCA3/MJD. Onset of eight cases (2.2%), all heterozygotes, was before adolescence: seven were females (p = 0.054). CAG expanded repeats--75 ± 3 versus 84 ± 4--and anticipations--7 ± 9.7 versus 14.4 ± 7.2 years--were different between early childhood and adult onset groups (p < 0.03). The median survival of early childhood onset group was 23 years of age. The annual progression of SARA--2.3 and 0.6 points/year (p = 0.001)--and NESSCA--2.04 and 0.88 points/year (p = 0.043)--was faster in childhood than in adult onset group. Onset of SCA3/MJD before adolescence was related to larger expanded CAG repeats in heterozygosis; females seemed to be at higher risk. Disease progression was faster than in SCA3/MJD starting after 12 years.

  9. Identità, attraversamenti e ibridismi nell'opera di Joseph O'Connor

    Directory of Open Access Journals (Sweden)

    Manfredi Bernardini

    2011-05-01

    Full Text Available This paper looks into the works of Irish writer Joseph O’Connor and his perspective in the process of redefining the spacial, temporal and cultural links between Ireland and the Unites States. In fact, a number of interesting points can be found throughout O’Connor works: the imagology (the image of the Irishman in the American culture; the investigation on prejudices and stereotypes (True Believers, 1991; border studies, although considered in a broader sense, one where the physical and geographical borders (the Atlantic Ocean appear to be symbolic and imaginary. Referring to the concept of Black Atlantic, as it was first proposed by Paul Gilroy, we can similarly imagine - acording to scholars such as David Lloyd and Peter O’Neill - a Green Atlantic, where the Ocean, after ceasing to represent a frontier, a border meant to separate, acquires a new meaning and becomes a place for bidirectional crossing: on the one hand as a means to cross over borders and synthesis between two cultures; in the other as a movement towards and beyond the limits of a Third Space, “a space of enunciation” and cultural negotiation, as Homi Bhabha would say. Other fundamental and recurring themes in the novels of O’Connor are identity and memory (Sweet Liberty Travels in Irish America, 1996, the “look” of the Others (Inishowen, 2000 and towards the Other (Redemption Falls, 2007 and, more importantly, the Irish diaspora towards the United States, spanning from the final years of the 19th century until the first half of the 20th, when, in some respect, the United States were looked upon as a “promised land” (this is mostly evident in the novel Star of the sea, 2002.

  10. Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.

    Science.gov (United States)

    Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa; den Dunnen, Wilfred F A; Hirai, Hirokazu; Kügler, Sebastian; Cavadas, Cláudia; Pereira de Almeida, Luís

    2015-10-01

    Machado-Joseph disease (MJD) is a fatal, dominantly inherited neurodegenerative disorder associated with an expanded polyglutamine tract within the ataxin-3 protein, and characterized by progressive impairment of motor coordination, associated with neurodegeneration of specific brain regions, including cerebellum and striatum. The currently available therapies do not allow modification of disease progression. Neuropeptide Y (NPY) has been shown to exert potent neuroprotective effects by multiple pathways associated with the MJD mechanisms of disease. Thus, we evaluated NPY levels in MJD and investigated whether raising NPY by gene transfer would alleviate neuropathological and behavioural deficits in cerebellar and striatal mouse models of the disease. For that, a cerebellar transgenic and a striatal lentiviral-based models of MJD were used. NPY overexpression in the affected brain regions in these two mouse models was obtained by stereotaxic injection of adeno-associated viral vectors encoding NPY. Up to 8 weeks after viral injection, balance and motor coordination behaviour and neuropathology were analysed. We observed that NPY levels were decreased in two MJD patients' cerebella and in striata and cerebella of disease mouse models. Furthermore, overexpression of NPY alleviated the motor coordination impairments and attenuated the related neuropathological parameters, preserving cerebellar volume and granular layer thickness, reducing striatal lesion and decreasing mutant ataxin-3 aggregation. Additionally, NPY mediated increase of brain-derived neurotrophic factor levels and decreased neuroinflammation markers. Our data suggest that NPY is a potential therapeutic strategy for MJD. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  11. Cancer in Machado-Joseph disease patients-low frequency as a cause of death.

    Science.gov (United States)

    Souza, Gabriele Nunes; Kersting, Nathália; Gonçalves, Thomaz Abramsson; Pacheco, Daphne Louise Oliveira; Saraiva-Pereira, Maria-Luiza; Camey, Suzi Alves; Saute, Jonas Alex Morales; Jardim, Laura Bannach

    2017-04-01

    Since polyglutamine diseases have been related to a reduced risk of cancer, we aimed to study the 15 years cumulative incidence of cancer (CIC) (arm 1) and the proportion of cancer as a cause of death (arm 2) in symptomatic carriers of spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). SCA3/MJD and control individuals from our state were invited to participate. A structured interview was performed. CIC as published by the Brazilian National Institute of Cancer, was used as populational control. Causes of death were obtained from the Public Information System on Mortality. We interviewed 154 SCA3/MJD patients and 80 unrelated controls: CIC was 7/154 (4.5%) and 5/80 (6.3%), respectively. The interim analysis for futility showed that the number of individuals required to detect a significant difference between groups (1938) would be three times larger than the existing local SCA3/MJD population (625), for an absolute risk reduction of 1.8%. Then this study arm was discontinued due to lack of power. In the same period, cancer was a cause of death in 9/101 (8.9%) SCA3/MJD and in 52/202 (26.2%) controls, with an absolute reduction risk of 17.3% (OR 0.27, 95%CI 0.13 to 0.58, p = 0.01). A significant reduction of cancer as cause of death was observed in SCA3/MJD, suggesting a common effect to all polyglutamine diseases. Copyright © 2017. Published by Elsevier Inc.

  12. Ataxin-3 and its E3 partners: Implications for Machado-Joseph disease

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    Thomas M Durcan

    2013-05-01

    Full Text Available Machado-Joseph disease (MJD is the most common dominant inherited ataxia worldwide, caused by an unstable CAG trinucleotide expansion mutation within the SCA3 gene resulting in an expanded polyglutamine tract within the ataxin-3 protein. Ataxin-3 functions as a deubiquitinating enzyme (DUB, within in the Ub system and whilst many DUBs are known to partner with and deubiquitinate specific E3-Ub-ligases, ataxin-3 had no identified E3 partner until recent studies implicated parkin and CHIP, two neuroprotective E3 ligases. MJD often presents with symptoms of Parkinson disease (PD, which led to identification of parkin as a novel E3 Ub-ligase whose activity was regulated by ataxin-3-mediated deubiquitination. Findings from these studies also revealed an unexpected convergence upon the E2 Ub-conjugating enzyme in the regulation of an E3/deubiquitinating enzyme pair. Moreover, mutant but not wild-type ataxin-3 promotes the clearance of parkin via the autophagy pathway, raising the intriguing possibility that increased turnover of parkin may contribute to the pathogenesis of MJD and help explain some of the parkinsonian features in MJD. In addition to parkin, the U-box E3 ligase CHIP, a neuroprotective E3 implicated in protein quality control, was identified as a second E3 partner of ataxin-3, with ataxin-3 regulating the ability of CHIP to ubiquitinate itself. Indeed, ataxin-3 not only deubiquitinated CHIP, but also trimmed Ub conjugates on CHIP substrates, thereby regulating the length of Ub chains. Interestingly, when expanded ataxin-3 was present, CHIP levels were also reduced in the brains of MJD transgenic mice, raising the possibility that loss of one or both E3 partners may be a contributing factor in the pathogenesis of SCA3. In this review we discuss the implications from these studies and describe the importance of these findings in helping us understand the molecular processes involved in SCA3 and other neurodegenerative disorders.

  13. Genetic counseling and presymptomatic testing programs for Machado-Joseph Disease: lessons from Brazil and Portugal.

    Science.gov (United States)

    Schuler-Faccini, Lavínia; Osorio, Claudio Maria; Romariz, Flavia; Paneque, Milena; Sequeiros, Jorge; Jardim, Laura Bannach

    2014-03-01

    Machado-Joseph disease (MJD) is an autosomal dominant, late-onset neurological disorder and the most common form of spinocerebellar ataxia (SCA) worldwide. Diagnostic genetic testing is available to detect the disease-causing mutation by direct sizing of the CAG repeat tract in the ataxin 3 gene. Presymptomatic testing (PST) can be used to identify persons at risk of developing the disease. Genetic counseling provides patients with information about the disease, genetic risks, PST, and the decision-making process. In this study, we present the protocol used in PST for MJD and the relevant observations from two centers: Brazil (Porto Alegre) and Portugal (Porto). We provide a case report that illustrates the significant ethical and psychological issues related to PST in late-onset neurological disorders. In both centers, counseling and PST are performed by a multidisciplinary team, and genetic testing is conducted at the same institutions. From 1999 to 2012, 343 individuals sought PST in Porto Alegre; 263 (77%) of these individuals were from families with MJD. In Porto, 1,530 individuals sought PST between 1996 and 2013, but only 66 (4%) individuals were from families with MJD. In Brazil, approximately 50% of the people seeking PST eventually took the test and received their results, whereas 77% took the test in Portugal. In this case report, we highlight several issues that might be raised by the consultand and how the team can extract significant information. Literature about PST testing for MJD and other SCAs is scarce, and we hope this report will encourage similar studies and enable the implementation of PST protocols in other populations, mainly in Latin America.

  14. Genetic counseling and presymptomatic testing programs for Machado-Joseph disease: lessons from Brazil and Portugal

    Directory of Open Access Journals (Sweden)

    Lavínia Schuler-Faccini

    2014-01-01

    Full Text Available Machado-Joseph disease (MJD is an autosomal dominant, late-onset neurological disorder and the most common form of spinocerebellar ataxia (SCA worldwide. Diagnostic genetic testing is available to detect the disease-causing mutation by direct sizing of the CAG repeat tract in the ataxin 3 gene. Presymptomatic testing (PST can be used to identify persons at risk of developing the disease. Genetic counseling provides patients with information about the disease, genetic risks, PST, and the decision-making process. In this study, we present the protocol used in PST for MJD and the relevant observations from two centers: Brazil (Porto Alegre and Portugal (Porto. We provide a case report that illustrates the significant ethical and psychological issues related to PST in late-onset neurological disorders. In both centers, counseling and PST are performed by a multidisciplinary team, and genetic testing is conducted at the same institutions. From 1999 to 2012, 343 individuals sought PST in Porto Alegre; 263 (77% of these individuals were from families with MJD. In Porto, 1,530 individuals sought PST between 1996 and 2013, but only 66 (4% individuals were from families with MJD. In Brazil, approximately 50% of the people seeking PST eventually took the test and received their results, whereas 77% took the test in Portugal. In this case report, we highlight several issues that might be raised by the consultand and how the team can extract significant information. Literature about PST testing for MJD and other SCAs is scarce, and we hope this report will encourage similar studies and enable the implementation of PST protocols in other populations, mainly in Latin America.

  15. Sauvegarde et valorisation du fonds d’archives familiales de Jean-Joseph Rabearivelo à Madagascar

    Directory of Open Access Journals (Sweden)

    Laurence Ink

    2014-04-01

    Full Text Available Figure essentielle et encore mal connue de la littérature malgache et internationale, Jean-Joseph Rabearivelo (1903‑1937 fut à la fois poète, journaliste et critique, dramaturge et romancier, historien de sa tradition, collecteur et traducteur de textes anciens comme de textes modernes. L’aventure qui débuta fin 2008 pour aboutir à la publication de ses œuvres complètes (AUF/ITEM, CNRS Éditions, Coll. Planète libre, Paris, 2 tomes, 2010 et 2012 consistait à sauvegarder l’important fonds d’archives familiales (plus de 800 manuscrits, tapuscrits, textes édités ou documents de travail confié par les ayant droits à l’Institut Français de Madagascar (Antananarivo, par un travail de tri, de numérisation et de mise en conditionnement neutre, in situ, et à le valoriser par l’édition des textes, pour une grande part inédits, dans une approche scientifique à caractère génétique. Expérience novatrice, structurée par une méthodologie devant constamment s’adapter aux exigences géographique, scientifique et éditoriale, elle est également à considérer comme un cas d’école, pour une meilleure approche des fonds d’archives littéraires, aujourd’hui en péril dans bon nombre de pays du Sud.

  16. Post-Colonial Analysis of Joseph Conrad’s Heart of Darkness

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    Samet Güven

    2013-07-01

    Full Text Available Joseph Conrad’s Heart of Darkness tells the journey of Marlow through the African jungle and his search for the European Kurtz who exploits the natives by imposing violence. It is mainly based upon Conrad’s own experience in Congo. Conrad learned how Europeans exploited and traded the natives for their own benefits during his own journey. The book is regarded as an attack on imperialism and criticizes immoral treatments of the European colonizers in Africa in the 19th century. Keith Booker states that “the book deals with issues such as imperialism, capitalism, race, and gender that were very much at the forefront of the turn-of-the century European mind. Conrad’s ambivalent treatment of these issues is extremely representative of the way they were treated in any number of European discourses of the time” (217. Besides, Chinua Achebe in his An “Image of Africa: Racism in Conrad’s Heart of Darkness” comments that “Heart of Darkness projects the image of Africa as ‘the other world’, the antithesis of Europe and therefore of civilization, a place where man’s vaunted intelligence and refinement are finally mocked by triumphant bestiality” (338. Although Achebe puts forward that the novel is in favor of colonialism, I consider that Conrad does not intend to write it to appreciate colonialism and therefore the purpose of this study is to approach Conrad’s Heart of Darkness from post-colonial perspective by taking European imperialism and colonialism over Africa into consideration in order to clarify how Conrad has deconstructed binary oppositions of colonialism by subverting the general idea of the Europeans towards Africa in the 19th century.

  17. Post-Colonial Analysis of Joseph Conrad’s Heart of Darkness

    Directory of Open Access Journals (Sweden)

    Samet Güven

    2013-06-01

    Full Text Available Joseph Conrad’s Heart of Darkness tells the journey of Marlow through the African jungle and his search for the European Kurtz who exploits the natives by imposing violence. It is mainly based upon Conrad’s own experience in Congo. Conrad learned how Europeans exploited and traded the natives for their own benefits during his own journey. The book is regarded as an attack on imperialism and criticizes immoral treatments of the European colonizers in Africa in the 19th century. Keith Booker states that “the book deals with issues such as imperialism, capitalism, race, and gender that were very much at the forefront of the turn-of-the century European mind. Conrad’s ambivalent treatment of these issues is extremely representative of the way they were treated in any number of European discourses of the time” (217. Besides, Chinua Achebe in his An “Image of Africa: Racism in Conrad’s Heart of Darkness” comments that “Heart of Darkness projects the image of Africa as ‘the other world’, the antithesis of Europe and therefore of civilization, a place where man’s vaunted intelligence and refinement are finally mocked by triumphant bestiality” (338. Although Achebe puts forward that the novel is in favor of colonialism, I consider that Conrad does not intend to write it to appreciate colonialism and therefore the purpose of this study is to approach Conrad’s Heart of Darkness from post-colonial perspective by taking European imperialism and colonialism over Africa into consideration in order to clarify how Conrad has deconstructed binary oppositions of colonialism by subverting the general idea of the Europeans towards Africa in the 19th century.

  18. Chief Joseph Kokanee Enhancement Project : Confederated Tribes of the Colville Reservaton 1997 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    LeCaire, Richard (Confederated Tribes of the Colville Reservation, Nespelem, WA)

    1998-01-01

    In the early 1980's the Confederated Tribes of the Colville Reservation, the Spokane Tribe of Indians and the Washington Dept. of Fish and Wildlife developed a management plan for Lake Roosevelt on the restoration and enhancement of kokanee salmon populations using hatchery out plants and the restoration of natural spawning runs. The plan was incorporated into the Northwest Power Planning Council (NPPC) in their 1987 Columbia Basin Fish and Wildlife program as partial mitigation for hydropower caused fish losses resulting from the construction of Grand Coulee Dam. The Chief Joseph Kokanee Enhancement Project, as part of a basin wide effort, is evaluating the status of the natural production kokanee in streams tributary to Lakes Roosevelt and Rufus Woods and is examining entrainment through Grand Coulee Dam. The goal of this project is the protection and enhancement of the natural production kokanee in these two lakes. The project is currently collecting data under four phases or parts. Since 1991, Lake Whatcom Washington origin kokanee have been planted in considerable numbers into the waters of Lake Roosevelt. A natural production kokanee fishery has persisted in the lake since the early 1970's(Cash, 1995), (Scholz, 1991). Historical information alludes to wild Kokanee production in the San Poil River, Nespelem River, Big Sheep Creek, Ora-Pa-Ken Creek, Deep Creek and Onion Creeks. The genetic makeup of the fish within the fishery is unknown, as is their contribution to the fishery. The level of influence by the hatchery out planted stock on wild fish stocks is unknown as well. Project outcomes will indicate the genetic fitness for inclusion of natural production kokanee stocks into current Bonneville Power Administration funded hatchery programs. Other findings may determine contribution/interaction of/between wild/hatchery kokanee stocks found in the waters of Lake Franklin D. Roosevelt.

  19. La robe et les mortiers. Joseph-Marie de Villespassans, magistrat faux-monnayeur (1713

    Directory of Open Access Journals (Sweden)

    Mathieu Soula

    2011-12-01

    Full Text Available Au début du XVIIIe siècle, un magistrat toulousain, le conseiller de Villepassans, est soupçonné d’être à la tête d’un réseau de faux-monnayeurs. L’affaire est sensible pour le parlement, qui instruit directement l’affaire, car il s’agit de poursuivre l’un de ses membres. Un magistrat faux-monnayeur est en effet une « figure » criminelle qui trouble et pose question. Par contagion, la mauvaise renommée de Villepassans peut atteindre les autres conseillers et porter le discrédit sur une institution qui se définit comme « le vrai vengeur des crimes ». Dans ces conditions, comment le parlement traite-t-il l’affaire, et quelle figure criminelle appose-t-il à Villespassans ? L’étude de ce cas atypique peut ainsi aider à mieux comprendre l’enjeu de la construction d’une identité criminelle.In early 18th century, a magistrate of the parliament of Toulouse, Joseph-Marie de Villespassans, is suspected of being the leader of forgers of money. This case is highly dangerous for the parliament, who’s in charge. The culpability of the magistrate-forger can also touch the others magistrates, and the prestige of the institution to. So, in these conditions, how can the parliament manage this case? I this research, we’re trying to study this atypical case in the way the parliament built the culpability.

  20. A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

    Science.gov (United States)

    Weber, Jonasz J; Golla, Matthias; Guaitoli, Giambattista; Wanichawan, Pimthanya; Hayer, Stefanie N; Hauser, Stefan; Krahl, Ann-Christin; Nagel, Maike; Samer, Sebastian; Aronica, Eleonora; Carlson, Cathrine R; Schöls, Ludger; Riess, Olaf; Gloeckner, Christian J; Nguyen, Huu P; Hübener-Schmid, Jeannette

    2017-05-01

    Ataxin-3, the disease protein in Machado-Joseph disease, is known to be proteolytically modified by various enzymes including two major families of proteases, caspases and calpains. This processing results in the generation of toxic fragments of the polyglutamine-expanded protein. Although various approaches were undertaken to identify cleavage sites within ataxin-3 and to evaluate the impact of fragments on the molecular pathogenesis of Machado-Joseph disease, calpain-mediated cleavage of the disease protein and the localization of cleavage sites remained unclear. Here, we report on the first precise localization of calpain cleavage sites in ataxin-3 and on the characterization of the resulting breakdown products. After confirming the occurrence of calpain-derived fragmentation of ataxin-3 in patient-derived cell lines and post-mortem brain tissue, we combined in silico prediction tools, western blot analysis, mass spectrometry, and peptide overlay assays to identify calpain cleavage sites. We found that ataxin-3 is primarily cleaved at two sites, namely at amino acid positions D208 and S256 and mutating amino acids at both cleavage sites to tryptophan nearly abolished ataxin-3 fragmentation. Furthermore, analysis of calpain cleavage-derived fragments showed distinct aggregation propensities and toxicities of C-terminal polyglutamine-containing breakdown products. Our data elucidate the important role of ataxin-3 proteolysis in the pathogenesis of Machado-Joseph disease and further emphasize the relevance of targeting this disease pathway as a treatment strategy in neurodegenerative disorders. © The Author (2017). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. Joseph in the Torah and the Qur’ān: An Assessment of Malik Bennabi’s Narrative.

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    Ibrahim M. Zein

    2008-12-01

    Full Text Available Normal 0 false false false EN-MY X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Abstract: Malek Bennabi’s The Qur’ānic Phenomenon provides an excellent analysis of Qur’ānic revelation through the application of the phenomenology. A closer analysis of the work shows that Bennabi’s major contribution is to be found in his narrative strategies and comparative style as evidenced, among others, in chapters 13 and 14 of the Qur’ānic Phenomenon. Here Bennabi provides a balanced picture of the story of Joseph in the Torah and the Qur’ān. Bennabi’s textual strategy, narrative and meta-narrative brings out the niqueness of the Qur’ānic account of Joseph. The reconstruction of the story of Joseph opened a new type of discourse in understanding the relationship between religion and modernity.

  2. Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.

    Science.gov (United States)

    Simões, Ana T; Gonçalves, Nélio; Koeppen, Arnulf; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos Bandeira; Pereira de Almeida, Luís

    2012-08-01

    Machado-Joseph disease is the most frequently found dominantly-inherited cerebellar ataxia. Over-repetition of a CAG trinucleotide in the MJD1 gene translates into a polyglutamine tract within the ataxin 3 protein, which upon proteolysis may trigger Machado-Joseph disease. We investigated the role of calpains in the generation of toxic ataxin 3 fragments and pathogenesis of Machado-Joseph disease. For this purpose, we inhibited calpain activity in mouse models of Machado-Joseph disease by overexpressing the endogenous calpain-inhibitor calpastatin. Calpain blockage reduced the size and number of mutant ataxin 3 inclusions, neuronal dysfunction and neurodegeneration. By reducing fragmentation of ataxin 3, calpastatin overexpression modified the subcellular localization of mutant ataxin 3 restraining the protein in the cytoplasm, reducing aggregation and nuclear toxicity and overcoming calpastatin depletion observed upon mutant ataxin 3 expression. Our findings are the first in vivo proof that mutant ataxin 3 proteolysis by calpains mediates its translocation to the nucleus, aggregation and toxicity and that inhibition of calpains may provide an effective therapy for Machado-Joseph disease.

  3. Medicine and music: a note on John Hunter (1728-93) and Joseph Haydn (1732-1809).

    Science.gov (United States)

    Fu, Louis

    2010-05-01

    Joseph Haydn was a central figure in the development and growth of the European classical musical tradition in its transition from the Baroque period. John Hunter as the Founder of Scientific Surgery was a dominant figure in 18th-century British medical science. Anne Hunter née Home (1742-1821) was in her own right a figure of some eminence in the literary circles of 18th-century London. Attracted to the burgeoning medical and musical scenes of London, John Hunter married Anne Home and became a famous surgeon; Haydn became acquainted with the Hunters. The people, the opportunities and the circumstances had coincided.

  4. "Four Ways of Writing the City" : St. Petersburg-Leningrad as a Metaphor in the Poetry of Joseph Brodsky

    OpenAIRE

    Könönen, Maija

    2003-01-01

    The present study discusses the theme of St. Petersburg-Leningrad in Joseph Brodsky's verse works. The chosen approach to the evolving im-age of the city in Brodsky's poetry is through four metaphors: St. Petersburg as "the common place" of the Petersburg Text, St. Petersburg as "Paradise and/or Hell", St. Petersburg as "a Utopian City" and St. Petersburg as "a Void". This examination of the city-image focusses on the aspects of space and time as basic categories underlying the poet's po...

  5. Joseph Lister: first use of a bacterium as a 'model organism' to illustrate the cause of infectious disease of humans.

    Science.gov (United States)

    Santer, Melvin

    2010-03-20

    Joseph Lister's goal was to show that a pure culture of Bacterium lactis, normally present in milk, uniquely caused the lactic acid fermentation of milk. To demonstrate this fact he devised a procedure to obtain a pure clonal population of B. lactis, a result that had not previously been achieved for any microorganism. Lister equated the process of fermentation with infectious disease and used this bacterium as a model organism, demonstrating its role in fermentation; from this result he made the inductive inference that infectious diseases of humans are the result of the growth of specific, microscopic, living organisms in the human host.

  6. Redescription of the fig wasp genus Sycophilodes Joseph (Chalcidoidea: Pteromalidae: Epichrysomallinae) with description of a new species from India.

    Science.gov (United States)

    Pramanik, Achintya; Dey, Debjani

    2014-07-18

    Sycophilodes Joseph is a non-pollinating fig wasp genus so far reported only from Ficus benghalensis L. The genus Sycophilodes is revised with redescription of the male and the first description of the female of its only currently included species, S. moniliformis. A second species, Sycophilodes uluberiaensis Pramanik & Dey sp. nov. is described. Available keys are modified and supplemented to facilitate identification of Sycophilodes and a key for distinguishing both sexes of the two included species is presented. All type specimens are deposited in the National Pusa Collection, IARI, New Delhi.

  7. Primary peritoneal carcinoma presenting as a Sister Mary Joseph's nodule: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Robyn L. Schickler

    2016-08-01

    Full Text Available Sister Mary Joseph's nodule is sometimes the first sign of an internal malignancy, including gastrointestinal, gynecological, or malignancy of unknown primary. It is rarely the sole presentation of a primary peritoneal cancer. In this report, we present the case of a 70-year-old female with umbilical drainage and a computed tomography scan consistent with solitary umbilical nodule. Excision of the nodule revealed adenocarcinoma of likely müllerian origin. Surgical staging did not show any evidence of malignancy with the exception of pelvic washings. She was considered to have primary peritoneal adenocarcinoma and was treated with adjuvant chemotherapy.

  8. Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy.

    Science.gov (United States)

    Watchon, Maxinne; Yuan, Kristy C; Mackovski, Nick; Svahn, Adam J; Cole, Nicholas J; Goldsbury, Claire; Rinkwitz, Silke; Becker, Thomas S; Nicholson, Garth A; Laird, Angela S

    2017-08-09

    The neurodegenerative disease Machado-Joseph disease (MJD), also known as spinocerebellar ataxin-3, affects neurons of the brain and spinal cord, disrupting control of the movement of muscles. We have successfully established the first transgenic zebrafish ( Danio rerio ) model of MJD by expressing human ataxin-3 protein containing either 23 glutamines (23Q, wild-type) or 84Q (MJD-causing) within neurons. Phenotypic characterization of the zebrafish (male and female) revealed that the ataxin-3-84Q zebrafish have decreased survival compared with ataxin-3-23Q and develop ataxin-3 neuropathology, ataxin-3 cleavage fragments and motor impairment. Ataxin-3-84Q zebrafish swim shorter distances than ataxin-3-23Q zebrafish as early as 6 days old, even if expression of the human ataxin-3 protein is limited to motor neurons. This swimming phenotype provides a valuable readout for drug treatment studies. Treating the EGFP-ataxin-3-84Q zebrafish with the calpain inhibitor compound calpeptin decreased levels of ataxin-3 cleavage fragments, but also removed all human ataxin-3 protein (confirmed by ELISA) and prevented the early MJD zebrafish motor phenotype. We identified that this clearance of ataxin-3 protein by calpeptin treatment resulted from an increase in autophagic flux (indicated by decreased p62 levels and increased LC3II). Cotreatment with the autophagy inhibitor chloroquine blocked the decrease in human ataxin-3 levels and the improved movement produced by calpeptin treatment. This study demonstrates that this first transgenic zebrafish model of MJD is a valuable tool for testing potential treatments for MJD. Calpeptin treatment is protective in this model of MJD and removal of human ataxin-3 through macro-autophagy plays an important role in this beneficial effect. SIGNIFICANCE STATEMENT We have established the first transgenic zebrafish model of the neurodegenerative disease MJD, and identified relevant disease phenotypes, including impaired movement from an early

  9. Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.

    Science.gov (United States)

    Simões, Ana Teresa; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos Bandeira; Pereira de Almeida, Luís

    2014-09-15

    Machado-Joseph Disease (MJD) is the most prevalent autosomal dominantly inherited cerebellar ataxia. It is caused by an expanded CAG repeat in the ATXN3 gene, which translates into a polyglutamine tract within the ataxin-3 protein. Present treatments are symptomatic and do not prevent disease progression. As calpain overactivation has been shown to contribute to mutant ataxin-3 proteolysis, translocation to the nucleus, inclusions formation and neurodegeneration, we investigated the potential role of calpain inhibition as a therapeutic strategy to alleviate MJD pathology. For this purpose, we administered orally the calpain inhibitor BDA-410 to a lentiviral mouse model of MJD. Western-blot and immunohistochemical analysis revealed the presence of N- and C-terminal mutant ataxin-3 fragments and the colocalization of large inclusions with cleaved caspase-3 in the mice brain. Oral administration of the calpain inhibitor BDA-410 decreased both fragments formation and full-length ataxin-3 levels, reduced aggregation of mutant ataxin-3 and prevented cell injury and striatal and cerebellar degeneration. Importantly, in correlation with the preserved cerebellar morphology, BDA-410 prevented motor behavioural deficits. In conclusion, BDA-410 alleviates Machado-Joseph neuropathology and may therefore be an effective therapeutic option for MJD. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  10. Os projetos de Joseph-Antoine Bouvard para o Vale Anhangabaú e Parque D. Pedro II

    Directory of Open Access Journals (Sweden)

    Oscar Felizardo Escudero

    2017-06-01

    Full Text Available Em 1911, inaugura-se no alto da encosta do Vale do Anhangabaú o Teatro Municipal de São Paulo, que associado à construção do Viaduto do Chá em 1892, traduzia a necessidade de um cenário mais condizente às transformações impostas pela economia agroexportadora (café e açúcar e por uma incipiente industrialização. Com efeito, em 1911, o francês Joseph-Antoine Bouvard, foi contratado para realizar dois projetos de embelezamento e funcionalidade para a cidade de São Paulo, conciliando os interesses políticos e econômicos da época. Estamos nos referindo ao Projeto para o Vale do Anhangabaú e para a Várzea do Carmo, que viria a se constituir no Parque D. Pedro II. Este projeto de pesquisa pretende investigar os antecedentes políticos e econômicos, que informaram os projetos do urbanista francês Joseph-Antoine Bouvard para a cidade de São Paulo, identificando as condições de seu financiamento e os interesses neles envolvidos.

  11. O crepúsculo da ética imperial habsburga em Bruno Schulz e Joseph Roth The twilight of the Habsburg imperial ethics in Bruno Schulz and Joseph Roth

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    Luis S. Krausz

    2007-05-01

    Full Text Available Os escritores Bruno Schulz e Joseph Roth entraram para a história da literatura, respectivamente, como representantes da literatura polonesa e austríaca, como se pertencessem a mundos diversos. Entretanto ambos compartilharam de uma memória comum, que era a vida nas províncias orientais do Império Austro-Húngaro, nas cidades de Drohobycz e Brody, hoje pertencentes à Ucrânia. As obras de ficção de Schulz e de Roth fazem referência ao universo austro-húngaro e habsburgo, um reino milenar que via a si mesmo não simplesmente como uma realidade política, mas como um império que tinha como missão trazer a seus súditos uma forma de vida considerada superior do ponto de vista espiritual, ético e moral. A idéia do Sacro Império Romano Germânico, que se considerava portador de uma mensagem humana, subsistiu, até o século 20, no longo reinado do Kaiser Francisco José e neste sentido a 1ª Guerra Mundial significa não simplesmente o desmembramento político do Império Austro-Húngaro em seus diferentes componentes, mas também a falência de uma idéia de Estado que transcendia à esfera do meramente político para tornar-se um lar espiritual e cultural para seus súditos. O mundo que sobreveio à 1ª Guerra Mundial é marcado pelas tendências fáustico-titânicas de um individualismo materialista, que devota todas suas energias à produção e à acumulação de capital, e é sobre este novo mundo que Schulz e Roth olham em suas obras, sempre do ponto de vista de um universo anterior, marcado pela nostalgia de um exílio irreversível. Palavras-chave: Nostalgia. Exílio. Império Habsburgo. Joseph Roth. Bruno Schulz. Bruno Schulz and Joseph Roth figure in the history of literature as Representatives of Polish and Austrian literature, respectively, as if they were part of different worlds. However, both share a common memory: the life in the eastern provinces of the Austrian-Hungarian Empire, in the cities of Drohobycz

  12. Friedrich Nietzsche'nin Joseph A.Schumpeter'in İktisat Düşüncesi Üzerindeki Etkisine Dair Bir Not = A Note on the Influence of Friedrich Nietzsche on the Economic Thought of Joseph A. Schumpeter

    Directory of Open Access Journals (Sweden)

    Ertuğrul KIZILKAYA

    2004-06-01

    Full Text Available The more original and provocative these which Joseph A. Schumpeter (1883-1950 developed in his work is that an heroic individual, the creative entrepreneur is the innovator of the dynamic economic system. This is the greatest personality who introduces new abilities to the productive forces of the economy. In this context, Nietzsche's thoughts have many similarities with those of Schumpeter's. On the other hand, there is a Nietzschean creative element in the vision of Schumpeter. As time passed, this element has been transformed into a more coherent analytical proposition to understand the very nature of the economic phenomenon. Despite the untestable character of some Schumpeterian analytical propositions, like the obsolescence of the entrepreneur or the danger of the decline of capitalism, we could have tolerance towards them in a rationally justified manner.

  13. L’influence de l’eugénisme galtonien dans la pensée de Joseph Alois Schumpeter The Influence of Eugenics in Joseph Alois Schumpeter’s theory

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    Fabrice Dannequin

    2012-11-01

    Full Text Available Dans sa théorie du capitalisme, Joseph Alois Schumpeter mobilise l’eugénique, notamment les travaux de Francis Galton. Ce dernier a élaboré une vision hiérarchisée et héréditariste des hommes. Il l’a notamment appliquée à la question de la pauvreté en reprenant les données empiriques de Charles Booth. Schumpeter reprend ces éléments comme socle de l’explication de l’inégalité sociale et dans la construction de sa théorie de l’entrepreneuriat. Les entrepreneurs constituent une élite se démarquant de la masse, en engendrant l’évolution de la société du fait de leurs talents innés. Le capitalisme ne peut déboucher sur la disparition totale de la pauvreté. En effet, les individus biologiquement moins « dotés » sont condamnés à rester au bas de l’échelle sociale.In his theory about capitalism, Joseph Alois Schumpeter uses eugenics, and especially Francis Galton’s work. The former has conceived a hierarchized vision of society, and a hereditary vision of the transmission of talents. He notably applied it to the question of poverty by using Charles Booth’s empirical data. Schumpeter uses these elements both as an explanation of social inequality and as a basis of his theory of entrepreneurship. To him, the entrepreneurs are an elite standing out against the masses since they have the innate talents to generate evolution. Capitalism cannot totally eradicate poverty. Indeed, the least biologically gifted are bound to remain at the bottom of the social ladder.

  14. Baron von Zach's business relations with the Munich entrepreneur Joseph von Utzschneider (German Title: Geschäftsbeziehungen des Barons von Zach zu dem Münchner Unternehmer Joseph von Utzschneider)

    Science.gov (United States)

    Schneider, Ivo

    The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.

  15. Review: Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa (2013

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    Reinhart Kößler

    2015-01-01

    Full Text Available Review of the monograph:Joseph Patrick Ganahl, Corruption, Good Governance, and the African State: A Critical Analysis of the Political-Economic Foundations of Corruption in Sub-Saharan Africa, Potsdam: Potsdam University Press, 2013, ISBN 9783869562483, 300 pp.

  16. A delicate balance global perspectives on innovation and tradition in the history of mathematics a festschrift in honor of Joseph W. Dauben

    CERN Document Server

    Horng, Wann-Sheng

    2015-01-01

    Joseph W. Dauben, a leading authority on the history of mathematics in Europe, China, and North America, has played a pivotal role in promoting international scholarship over the last forty years. This Festschrift volume, showcasing recent historical research by leading experts on three continents, offers a global perspective on important themes in this field.

  17. Close but No Cigar (Yet): A Commentary on "Has Consultation Achieved Its Primary Prevention Potential?," an Article by Joseph E. Zins

    Science.gov (United States)

    Love, Kelly Brey

    2007-01-01

    More than a decade ago, Joseph Zins (1995) hypothesized that consultation had the power to prevent children from developing academic, social, emotional, and related problems. To date, empirical research has yet to fully validate its value. This commentary discusses the potential benefit of consultation as a preventive measure, identifies ways to…

  18. 33 CFR 334.670 - Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Mexico south and west of Apalachicola, San Blas, and St. Joseph bays; air-to-air firing practice range, Tyndall Air Force Base, Fla. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.670 Gulf of Mexico south and west of...

  19. Joseph Roth in den Niederlanden und Flandern: Vermittlung, Vernetzung und Orchestierung eines vielseitigen Autors im niederländischsprachigen Kontext 1924-1940

    NARCIS (Netherlands)

    Snick, E.S.

    2011-01-01

    This dissertation investigates the contemporary mediators and networks that played an important role in the canonization of Joseph Roth’s (original and translated) work in Flanders and the Netherlands. These mediators and networks made a substantial contributionto Roth’s intellectual and literary

  20. Romantic Joseph Lenné Landscape Park in Zatonie Near Zielona Góra as a Relic of Garden Art - Modern-Day Transformations and Threats

    Directory of Open Access Journals (Sweden)

    Kochańska Agnieszka

    2016-09-01

    Full Text Available The romantic landscape park was established in 1824 by order of one of the best-known aristocrats at the time, Princess Dorothea Talleyrand Perigold, Dutchess of Dino. The park is an example of amenity horticulture of artistic value that has survived to this day. The creator of the park was the talented landscape architect Peter Joseph Lenné.

  1. A comparative study of blood flow in the cerebellum and brainstem between Machado-Joseph disease and olivopontocerebellar atrophy

    International Nuclear Information System (INIS)

    Fukumitsu, Nobuyoshi; Suzuki, Masahiko; Ito Yasuhiko; Iguchi, Yasuyuki; Mori, Yutaka

    2002-01-01

    In recent years, the neurogenic and pathological differences between Machado-Joseph disease (MJD) and sporadic olivopontocerebellar atrophy (OPCA) have been clarified. We performed N-isopropyl-p-[I-123] iodoamphetamine (IMP) SPECT on 9 patients with MJD and 12 patients with OPCA. The blood flow of the cerebellum in the MJD group was significantly decreased than that of the control group (p<0.0001). That of OPCA group was significantly decreased than those of the control and MJD groups (p<0.0001, respectively). The blood flow of the brainstem in the MJD group was significantly decreased than that of the control group (p<0.001). That of OPCA group was significantly decreased than those of the control and MJD groups (p<0.0001, respectively). The blood flow of cerebellum and brainstem in the OPCA group were much decreased than those of MJD group. IMP distribution pattern in MJD patients obviously differed from that of OPCA patients. (author)

  2. The good listeners: Joseph Mitchell (U.S., José Hamilton Ribeiro (Brazil and Literary Journalism

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    Monica Martinez

    2011-02-01

    Full Text Available The article discusses the experience of Joseph Mitchell, an American literary journalist who humanized the art of profiles, writing in a personal and emotional style for The New Yorker magazine from 1938 until 1996, and José Hamilton Ribeiro, a Brazilian journalist who used to work for Realidade magazine from 1966 through 1975 and now is a Globo TV special reporter. It also suggests the usability in Journalism of a more profound interview approach as a method to better analyze and comprehend complex realities. The present study aims at a reflection on the role of journalists as readers, writers and producers of meaning in the contemporary world, as well as on the effect of this profound interaction between environment and interviewers on the journalist’s personal and professional life.

  3. The good listeners: Joseph Mitchell (U.S., José Hamilton Ribeiro (Brazil and Literary Journalism

    Directory of Open Access Journals (Sweden)

    Monica Martinez

    2008-06-01

    Full Text Available The article discusses the experience of Joseph Mitchell, an American literary journalist who humanized the art of profiles, writing in a personal and emotional style for The New Yorker magazine from 1938 until 1996, and José Hamilton Ribeiro, a Brazilian journalist who used to work for Realidade magazine from 1966 through 1975 and now is a Globo TV special reporter. It also suggests the usability in Journalism of a more profound interview approach as a method to better analyze and comprehend complex realities. The present study aims at a reflection on the role of journalists as readers, writers and producers of meaning in the contemporary world, as well as on the effect of this profound interaction between environment and interviewers on the journalist’s personal and professional life.

  4. SERMONS PARODIQUES ET PRÊCHEURS COMIQUES DANS LE COMPÈRE MATHIEU DE HENRI-JOSEPH DULAURENS (1766)

    OpenAIRE

    DIDIER GAMBERT

    2011-01-01

    RésuméL’article a pour objet de montrer en quoi Le Compère Mathieu de Henri-Joseph Dulaurens (1766) situe son discours en marge des Lumières, dont il reprend les présupposés tout en se plaçant dans une ambiguïté problématique, et ce à travers l’étude de l’éloquence de la chaire qui sous-tend les prises de parole de la plupart des personnages. Ce phénomène peut sembler logique quand on a affaire à certains représentants de la pensée des Jésuites, notamment Diego, mais on s’aperçoit que le disc...

  5. Handwerklicher Hintergrund und Perspektiven akademischer Studien. Zum Frühwerk Joseph Führichs in Böhmen

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    Machalíková, Pavla

    2013-11-01

    Full Text Available The study of the early works by Joseph Führich helps to elucidate his role in the formation of the national schools of painting as understood by the early 19th century. It also reveals the links between the academic schooling and paintings of the artist (regarded as one of the leading representatives of Romanticism in the early 1820s in Prague and his commissioned works of the period intended for more traditional clients and public – altar paintings for Northern Bohemian churches. An analysis of his most important paintings from around the mid-1820s indicates, that he managed to integrate various elements into highly specific personal style: craftsmanship acquired in his father's workshop, elements inspired by old art, academic schooling, and inspiration provided by contemporary Romantic art and iconography.

  6. A question of merit: John Hutton Balfour, Joseph Hooker and the 'concussion' over the Edinburgh chair of botany.

    Science.gov (United States)

    Bellon, Richard

    2005-03-01

    In 1845, Robert Graham's death created a vacancy for the traditionally dual appointment to the University of Edinburgh's chair of botany and the Regius Keepership of the Edinburgh Royal Botanic Garden. John Hutton Balfour and Joseph Hooker emerged as the leading candidates. The contest quickly became embroiled in long running controversies over the nature and control of Scottish university education at a time of particular social and political tension after a recent schism in Church of Scotland. The politics of the appointment were complicated by the fact that the Edinburgh Town Council (which preferred Balfour) chose the chair while the keepership was under the patronage of the Westminster government (which preferred Hooker). Balfour eventually emerged triumphant after a bitter campaign marked on all sides by intense politicking. The struggle to replace Graham provides a case study in how Victorian men of science adapted their aspirations to the practical realities of life in industrial, reforming, imperial, multinational Britain.

  7. A "next generation" ethics committee. St. Joseph Health system has integrated performance-improvement features into its ethics work.

    Science.gov (United States)

    Murphy, Kevin

    2006-01-01

    Understanding the limitations that accompany the traditional model of ethics committees, St. Joseph Health System (SJHS), Orange, CA, has been working to integrate ethics expertise and quality-improvement methodology into its "Next Generation Model" (NG Model) for such committees. However, moving from a traditional structure to the NG Model (introduced to SJHS facilities in 1999) brought some challenges, not the least of which was a deep-rooted culture of resistance to change. Following a 2004 audit of how the NG model was working, some common challenges were identified. To deal with those challenges, SJHS developed some tools and techniques that have helped ease the ongoing transition. These tools have helped the system's ethics committees address such issues as collaboration for the sake of organizational integration, setting goals, and measuring performance of various ethics roles.

  8. Beyond antisepsis: Examining the relevance of the works of Joseph Baron Lister to the contemporary surgeon-scientist

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    Graeme E Glass

    2014-01-01

    Full Text Available As the father of antispesis, the legacy of Joseph Baron Lister is assured and his influence on the development of contemporary surgical practice is recognised in the context of his achievement of predictable, infection-free surgery. However, looking beyond Lister′s finest achievement and examining this work in the context of his whole career as a surgeon-scientist reveals important lessons pertinent to aspiring peers in how, by replacing surgical dogma with observation, deductive reasoning and scientific verification, by pursuing good ideas in the face of resistance and by making research directly relevant and patient-focused, lasting changes can be accomplished. This short paper aims to put Lister′s developments in antisepsis in the context of his whole career, to evaluate his legacy and to commend his approach to contemporary surgeon-scientists.

  9. Beyond antisepsis: Examining the relevance of the works of Joseph Baron Lister to the contemporary surgeon-scientist.

    Science.gov (United States)

    Glass, Graeme E

    2014-01-01

    As the father of antispesis, the legacy of Joseph Baron Lister is assured and his influence on the development of contemporary surgical practice is recognised in the context of his achievement of predictable, infection-free surgery. However, looking beyond Lister's finest achievement and examining this work in the context of his whole career as a surgeon-scientist reveals important lessons pertinent to aspiring peers in how, by replacing surgical dogma with observation, deductive reasoning and scientific verification, by pursuing good ideas in the face of resistance and by making research directly relevant and patient-focused, lasting changes can be accomplished. This short paper aims to put Lister's developments in antisepsis in the context of his whole career, to evaluate his legacy and to commend his approach to contemporary surgeon-scientists.

  10. José Ignacio Moreno. Un teólogo peruano. Entre Montesquieu y Joseph de Maistre

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    Victor Samuel Rivera

    2013-01-01

    Full Text Available José Ignacio Moreno es uno de los fundadores de la independencia del Perú. En calidad de tal acompañó el proyecto del General rioplatense José de San Martín de transformar en 1822 la monarquía peruana en un reino independiente. Pero, a diferencia de la multitud de sus contemporáneos, la historiografía apenas lo presenta como un circunstante en la epopeya de la emancipación, de quien no se conserva ni un retrato. El motivo es la extraña adherencia de este personaje a las ideas del ultramontanismo y su temprana cercanía con la obra del contrarrevolucionario francés Joseph de Maistre. Un discurso monárquico extremista en 1822 lo colocaría como el fundador involuntario del Perú como República.

  11. Comparative Aesthetics of the Manly Face in the Parties of the Prophet Joseph and Zuleika from Safavid Era to the Contemporary Era

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    Maryam Shahbazi

    2017-02-01

    Full Text Available One of the noteworthy stories for the Iranian writers and painters is the story of Joseph and Zuleika. This story has elegantly been described many times in the poetry of Iranian famous poets and many painters have sought to illustrate this story. One of the themes of this story which has been considered in the present research is the party of Joseph and Zuleika in confronting with Egyptian women. Because the subject matter of this party has been Joseph’s beauty and it has been confirmed by a large number of people. Therefore, the painters have tried to picture the most beautiful human being by using all visual techniques. This research studies the aesthetics of the Joseph’s figure from Safavid School to the art of the contemporary era. With this assumption that in the Iranian painting, there has been a certain principle for painting the body and face of the most beautiful people; the present paper with the aim of finding the principles of men’s body and facial aesthetic has done the comparative study by concentration on the painting and designing of the body and face of Joseph in the figures. Some questions have been presented in this regard including whether it is possible to find an aesthetic approach common to all Iranian painting schools to show the most beautiful manly face and body? Whether exemplary beauty of Joseph is expressible by an indicator? What relation has the exemplary of Joseph had with the schools of Safavid art and the following schools? The method of this research is comparative and content analysis. The paper refers to the written and illustrated sources. The statistical society, including six ceremonies of painting and drawing, has been analyzed from Safavid school till the contemporary art; also, painter artists of this circle have been introduced. Matching the theoretical findings with the men’s most beautiful appearance manifested in the statue of majesty Joseph causes the acquisition of the embodied beauty

  12. The role of the patient's remembered history and unconscious past in the evolution of Betty Joseph's 'Here and now' clinical technique (1959-1989).

    Science.gov (United States)

    Aguayo, Joseph

    2011-10-01

    The author historicizes one aspect of Betty Joseph's ongoing technical contributions in terms of its originating London kleinian context. Early on she drew upon both the patient's remembered history and unconscious past, linking these experiences in past-to-present transference interpretations in order to effect psychic change. In evolving the technique of 'here and now' analysis, Joseph came to emphasize a communicative definition of projective and introjective identification as well as the significance of enactments while marginalizing the use of part-object anatomical interpretative language. She gradually set aside directly linking the patient's past with the present, compelled now by making direct contact with her patients. She now tracked how difficult patients acted in and responded to interpretations from moment to moment. The author maintains that the explicit and implicit conceptual work of Wilfred Bion as well as Joseph's continuous group workshop for analysts led to an increased understanding of the patient's projective impact on the analyst's countertransference responses, and thereby increased the analyst's capacity with 'difficult to treat' narcissistic spectrum patients described by her colleague, Herbert Rosenfeld. In recent work, while Joseph continues to elucidate what patients recall about their early past, she formats her understanding in terms of a direct analysis of the structure of the patient's projected internal object relations in the transference. The analyst works with the patient's communications and enactments, with a greater emphasis on a more 'inside-to-outside' understanding of transference in contrast to the earlier 'past-to-present' work associated with both Freud and Klein. This investigation concludes with one example of Betty Joseph's significant impact on contemporary kleinian technique by taking up some of Michael Feldman's work. Now the analyst listens to the 'past presented,' the patient's projected internal world, as well

  13. Imaginário religioso: o simbolismo do herói à luz de Joseph Campbell e Carl Gustav Jung. 2011.

    Directory of Open Access Journals (Sweden)

    Solange Missagia Matos

    2013-03-01

    Full Text Available DISSERTAÇÃO DE MESTRADOMATTOS, Solange Missagia. Imaginário religioso: o simbolismo do herói à luz de Joseph Campbell e Carl Gustav Jung. 2011. 115 folhas. Dissertação (Mestrado – Pontifícia Universidade Católica de Minas Gerais, Programa de Pós-graduação em Ciências da Religião, Belo Horizonte.

  14. Machado-Joseph Disease in the context of the person/family that experiences it: daily changes and future expectations Doença de Machado-Joseph no contexto da pessoa/família que a vivencia: alterações cotidianas e expectativas futuras

    Directory of Open Access Journals (Sweden)

    Micheli Vieira Della Giustina

    2017-10-01

    Full Text Available Objetivo: Conhecer as principais alterações cotidianas e as expectativas futuras vivenciadas pela pessoa/família com a Doença de Machado-Joseph.  Métodos: Pesquisa exploratória, descritiva de abordagem qualitativa, realizada com sete familiares de uma pessoa com a doença de Machado-Joseph, em uma cidade do Rio Grande do Sul. Os dados coletados durante uma visita domiciliar realizada no mês de abril de 2016, por meio de entrevista semiestruturada e observação participante, foram submetidos à análise de conteúdo. Resultados: Emergiram cinco categorias: (Desconhecimento da doença antes do diagnóstico; Conhecimento da doença após o diagnóstico; Dificuldades do diagnóstico; Alterações vivenciadas após o diagnóstico; Expectativas para o futuro com a doença de Machado-Joseph. Conclusão: Torna-se necessário, mais investimento por parte dos profissionais da saúde, especialmente dos enfermeiros, na realização de estudos voltados a buscar auxiliar as pessoas/familiares que convivem com a Doença de Machado-Joseph.

  15. 'Items for criticism (not in sequence)': Joseph DeLee, Pare Lorentz and The Fight for Life (1940).

    Science.gov (United States)

    Gainty, Caitjan

    2017-09-01

    In the late 1920s, the American obstetrician Joseph DeLee brought the motion-picture camera into the birth room. Following that era's trend of adapting industrial efficiency practices for medical environments, DeLee's films give spectacular and unexpected expression to the engineering concept of 'streamlining'. Accomplishing what more tangible obstetric streamlining practices had failed to, DeLee's cameras, and his post-production manipulation, shifted birth from messy and dangerous to rationalized, efficient, death-defying. This was film as an active and effective medical tool. Years later, the documentarian Pare Lorentz produced and wrote his own birth film, The Fight for Life (1940). The documentary subject of the film was DeLee himself, and the film was set in his hospitals, on the same maternity 'sets' that had once showcased film's remarkable streamlining capacity to give and keep life. Yet relatively little of DeLee was retained in the film's content, resulting in a showdown that, by way of contrast, further articulated DeLee's understanding of film's medical powers and, in so doing, hinted at a more dynamic moment in the history of medicine while speaking also to the process by which that understanding ceased to be historically legible.

  16. Jules and Augusta Dejerine, Pierre Marie, Joseph Babiński, Georges Guillain and their students during World War I.

    Science.gov (United States)

    Walusinski, O

    2017-03-01

    World War I (1914-1918), however tragic, was nonetheless an "edifying school of nervous system experimental pathology" not only because of the various types of injuries, but also because their numbers were greater than any physician could have foreseen. The peripheral nervous system, the spine and the brain were all to benefit from the subsequent advances in clinical and anatomo-functional knowledge. Neurosurgeons took on nerve sutures, spinal injury exploration, and the localization and extraction of intracranial foreign bodies. Little by little, physical medicine and rehabilitation were established. A few of the most famous Parisian neurologists at the time-Jules and Augusta Dejerine, Pierre Marie, Joseph Babiński and Georges Guillain, who directed the military neurology centers-took up the physically and emotionally exhausting challenge of treating thousands of wounded soldiers. They not only cared for them, but also studied them scientifically, with the help of a small but devoted band of colleagues. The examples presented here reveal their courage and their efforts to make discoveries for which we remain grateful today. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  17. Mountford Joseph Bramley: A pioneering thyroidologist and the first principal of Asia′s oldest medical college

    Directory of Open Access Journals (Sweden)

    Subhankar Chatterjee

    2015-01-01

    Full Text Available Mountford Joseph Bramley was one of the educationists whose sincere efforts are undeniable in the making of modern India. After achieving the Member of the Royal College of Surgeons diploma, he joined the Malta Garrison as a Hospital Assistant and was soon promoted to the rank of Assistant Surgeon of the Rifle Brigade. Following his arrival in India in 1826, he held several important medical posts in the British service. He was one of the early researchers to investigate the role of iodine in the causation of goitre. He was appointed as the first Principal of the Medical College of Bengal, the oldest medical college in Asia, in 1835. Bramley was an educationist from the very core of his heart, and he always wished for the betterment of his students. He died early at the age of 34 years. His legacy as a pioneer in the fields of medical education and endocrinology, specifically thyroidology, has largely been shrouded in a miasma of time.

  18. Adapting to the emergence of the automobile: a case study of Manchester coachbuilder Joseph Cockshoot and Co. 1896–1939

    Directory of Open Access Journals (Sweden)

    Joshua Butt

    2017-11-01

    Full Text Available Today motor vehicles are ubiquitous. Yet at the end of the nineteenth century motoring was a new pastime, and there were only a few hundred motorised vehicles on the road. Many believed motoring to be a fad and motorists faced opposition on many fronts, from local corporations, the police and rural residents. Coachbuilders also had an uneasy relationship with this new technology. Automobile manufacturers and customers required coachbuilders’ skills to build motorcar bodies. Yet the growth of the automobile began to affect the use of horse-drawn transport during the first decade of the twentieth century. This paper will analyse the relationship between the horse-drawn and the motorised vehicle in the UK during this transitional period before exploring the records of Manchester coachbuilder Joseph Cockshoot and Co. that survive at the Museum of Science and Industry Archive. This collection offers a rare insight into the dilemmas faced by coachbuilders in this era of transition. This paper argues that the emergence of the automobile was not a simple matter of technological progress, but involved complex relationships between manufacturers, coachbuilders and customers.

  19. Joseph A. Burton Forum Award Talk: Remembering our Humanity: the deep impact of the Russell-Einstein Manifesto

    Science.gov (United States)

    Lewis, Patricia M.

    2009-05-01

    ``There lies before us, if we choose, continual progress in happiness, knowledge, and wisdom. Shall we, instead, choose death, because we cannot forget our quarrels? We appeal as human beings to human beings: Remember your humanity, and forget the rest.'' Days before his death, Albert Einstein joined Bertrand Russell and other notable scientists and philosophers in issuing a statement calling for the abolition of war and for governments to ``find peaceful means for the settlement of all matters of dispute between them." As a first step, they called for the renunciation of nuclear weapons. The initiative led to the establishment of the Pugwash Conferences on Science and World Affairs, which bring together influential scholars and public figures concerned with reducing the danger of armed conflict and seeking cooperative solutions for global problems. The Russell-Einstein Manifesto has had a major impact on the way in which people discuss the issues of peace and war. The paper traces the growing awareness of the meaning of war, ways in which violent conflict can be prevented, particularly in the nuclear age, and the humanitarian imperative for so doing. From the Russell-Einstein Manifesto, London, 9 July 1955, signed also by Max Born, Percy W. Bridgman, Leopold Infeld, Frederic Joliot-Curie, Herman J. Muller, Linus Pauling, Cecil F. Powell, Joseph Rotblat and Hideki Yukawa

  20. Joseph S. Weiner and the foundation of post-WW II human biology in the United Kingdom.

    Science.gov (United States)

    Little, Michael A; Collins, Kenneth J

    2012-01-01

    Both the United States and the United Kingdom experienced a transformation in the science of physical anthropology from the period before World War II until the post-war period. In the United States, Sherwood L. Washburn is credited with being a leading figure in this transformation. In the United Kingdom, two individuals were instrumental in bringing about a similar change in the profession. These were Joseph S. Weiner at the University of Oxford and Nigel Barnicot at the University of London, with Weiner playing the principal role as leader in what Washburn called the "New Physical Anthropology," that is, the application of evolutionary theory, the de-emphasis on race classification, and the application of the scientific method and experimental approaches to problem solving. Weiner's contributions to physical anthropology were broad-based--climatic and work physiology, paleoanthropology, and human variation--in what became known as human biology in the U.K. and human adaptability internationally. This biographical essay provides evidence for the significant influence of J.S. Weiner on the post-war development of human biology (biological or physical anthropology) inthe U.K. Copyright © 2012 Wiley Periodicals, Inc.

  1. Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease

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    C.M. Lopes-Ramos

    Full Text Available Machado-Joseph disease (MJD or spinocerebellar ataxia type 3 (SCA3 is an autosomal dominant neurodegenerative disorder caused by expansion of the polyglutamine domain of the ataxin-3 (ATX3 protein. MJD/SCA3 is the most frequent autosomal dominant ataxia in many countries. The mechanism underlying MJD/SCA3 is thought to be mainly related to protein misfolding and aggregation leading to neuronal dysfunction followed by cell death. Currently, there are no effective treatments for patients with MJD/SCA3. Here, we report on the potential use of lithium carbonate and coenzyme Q10 to reduce cell death caused by the expanded ATX3 in cell culture. Cell viability and apoptosis were evaluated by MTT assay and by flow cytometry after staining with annexin V-FITC/propidium iodide. Treatment with lithium carbonate and coenzyme Q10 led to a significant increase in viability of cells expressing expanded ATX3 (Q84. In addition, we found that the increase in cell viability resulted from a significant reduction in the proportion of apoptotic cells. Furthermore, there was a significant change in the expanded ATX3 monomer/aggregate ratio after lithium carbonate and coenzyme Q10 treatment, with an increase in the monomer fraction and decrease in aggregates. The safety and tolerance of both drugs are well established; thus, our results indicate that lithium carbonate and coenzyme Q10 are good candidates for further in vivo therapeutic trials.

  2. Birth of scientific surgery. John Hunter versus Joseph Lister as the father or founder of scientific surgery.

    Science.gov (United States)

    Toledo-Pereyra, Luis H

    2010-02-01

    John Hunter (1728-1793) has frequently been considered the "Father or Founder of Scientific Surgery". His inscription at Westminster Abbey presents him as "a gifted interpreter of the Divine Power and wisdom at work in the laws of organic life and the Founder of Scientific Surgery." I take issue with Hunter being considered the father or founder of scientific surgery and propose Joseph Lister (1827-1912) as the one who should receive this consideration. Hunter was a skilled surgeon, an inquisitive innovator, keen observer, great naturalist, and astute thinker, who made no surgical discoveries of any transcendence to the discipline. His scientific observations were not in the field of surgery. Therefore, he should not be considered the "Father or Founder of Scientific Surgery." On the contrary, Lister became a revolutionary scientific innovator by explaining the pervasive role of microorganisms in surgical wounds. His work directly affected surgery and its role in medicine. Lister, therefore, should be considered the "Father or Founder of Scientific Surgery."

  3. Moral absolutism and the double-effect exception: reflections on Joseph Boyle's Who is entitled to double effect?

    Science.gov (United States)

    Donagan, A

    1991-10-01

    Joseph Boyle raises important questions about the place of the double-effect exception in absolutist moral theories. His own absolutist theory (held by many, but not all, Catholic moralists), which derives from the principles that fundamental human goods may not be intentionally violated, cannot dispense with such exceptions, although he rightly rejects some widely held views about what they are. By contrast, Kantian absolutist theory, which derives from the principle that lawful freedom must not be violated, has a corollary--that it is a duty, where possible, to coerce those who try to violate lawful freedom--which makes superfluous many of the double-effect exceptions Boyle allows. Other implications of the two theories are contrasted. Inter alia, it is argued that, in Boyle's theory, that a violation of a fundamental human good can be viewed as a cost proportionate to a benefit obtained, cannot yield a double-effect exception to the prohibition of intentionally violating that good, because paying a cost cannot be unintentional.

  4. Neurophysiological studies and non-motor symptoms prior to ataxia in a patient with machado-joseph disease: trying to understand the natural history of brain degeneration.

    Science.gov (United States)

    Pedroso, José Luiz; Bor-Seng-Shu, Edson; Braga-Neto, Pedro; Ribeiro, Rodrigo Souza; Bezerra, Márcio Luiz Escorcio; do Prado, Lucila B F; Batista, Ilza Rosa; Alessi, Helena; Teixeira, Manoel Jacobsen; Manzano, Gilberto Mastrocola; do Prado, Gilmar Fernandes; Barsottini, Orlando Graziani Povoas

    2014-08-01

    Spinocerebellar ataxia type 3 or Machado-Joseph disease is the most common spinocerebellar ataxia. In this neurological disease, anatomical, physiological, clinical, and functional neuroimaging demonstrate a degenerative process besides the cerebellum. We performed neurophysiological and neuroimaging studies-polysomnography, transcranial sonography, vestibular-evoked myogenic potential, single-photon emission computed tomography (SPECT) with (99m)Tc-TRODAT-1, and a formal neuropsychological evaluation in a patient with sleep complaints and positive testing for Machado-Joseph disease, without cerebellar atrophy, ataxia, or cognitive complaints. Polysomnography disclosed paradoxical high amplitude of submental muscle, characterizing REM sleep without atonia phenomenon. Transcranial sonography showed hyperechogenicity of the substantia nigra. There was an absence of vestibular-evoked myogenic potentials on both sides in the patient under study, in opposite to 20 healthy subjects. Brain imaging SPECT with (99m)Tc-TRODAT-1 demonstrated a significant lower DAT density than the average observed in six healthy controls. Electroneuromyography was normal. Neuropsychological evaluation demonstrated visuospatial and memory deficits. Impairment of midbrain cholinergic and pontine noradrenergic systems, dysfunction of the pre-synaptic nigrostriatal system, changes in echogenicity of the substantia nigra, and damage to vestibulo-cervical pathways are supposed to occur previous to cerebellar involvement in Machado-Joseph disease.

  5. Rationing medical education | Walsh | African Health Sciences

    African Journals Online (AJOL)

    Even though some stakeholders in medical education might be taken aback at the prospect of rationing, the truth is that rationing has always occurred in one form or another in medical education and in healthcare more broadly. Different types of rationing exist in healthcare professional education. For example rationing may ...

  6. Risk assessment for the reintroduction of anadromous salmonids upstream of Chief Joseph and Grand Coulee Dams, Northeastern Washington

    Science.gov (United States)

    Hardiman, Jill M.; Breyta, Rachel B.; Haskell, Craig A.; Ostberg, Carl O.; Hatten, James R.; Connolly, Patrick J.

    2017-09-12

    The Upper Columbia United Tribes (UCUT; Spokane, Colville, Kootenai, Coeur d’Alene, and Kalispel Tribes) and Washington Department of Fish and Wildlife want to reintroduce anadromous salmonids to their historical range to restore ecosystem function and lost cultural and spiritual relationships in the upper Columbia River, northeastern Washington. The UCUT contracted with the U.S. Geological Survey to assess risks to resident taxa (existing fish populations in the reintroduction area upstream of Chief Joseph and Grand Coulee Dams) and reintroduced salmon associated with reintroduction. We developed a risk assessment framework for reintroduction of anadromous salmonids upstream of Chief Joseph and Grand Coulee Dams. To accomplish this goal, we applied strategies identified in previous risk assessment frameworks for reintroduction. The risk assessment is an initial step towards an anadromous reintroduction strategy. An initial list of potential donor sources for reintroduction species was developed from previous published sources for Chinook Salmon (Oncorhynchus tshawytscha) donors in the Transboundary Reach of the Columbia River, British Columbia; an ecological risk assessment of upper Columbia River hatchery programs on non-target taxa of concern; and a review of existing hatchery programsDuring two workshops, we further identified and ranked potential donor sources of anadromous Redband Trout (steelhead; O. mykiss), Chinook Salmon, Sockeye Salmon (O. nerka), and Coho Salmon (O. kisutch). We also identified resident fish populations of interest and their primary habitat, location, status, and pathogen concerns to determine the potential risks of reintroduction. Species were deemed of interest based on resource management and potential interactions (that is, genetics, competition, and predation) with introduced species. We developed tables of potential donors by species and characterized potential sources (hatchery and natural origins), populations (individual runs

  7. Normal ATXN3 allele but not CHIP polymorphisms modulates age at onset in Machado-Joseph Disease

    Directory of Open Access Journals (Sweden)

    Marcondes C. França Jr

    2012-11-01

    Full Text Available Background: Age at onset (AO in Machado-Joseph disease (MJD is closely associated with the length of the CAG repeat at the mutant ATXN3 allele, but there are other intervening factors. Experimental evidence indicates that the normal ATXN3 allele and the C-terminal heat shock protein 70 (Hsp70-interacting protein (CHIP may be genetic modifiers of AO in MJD. Methods: To investigate this hypothesis, we determined the length of normal and expanded CAG repeats at the ATXN3 gene in 210 unrelated patients with MJD. In addition, we genotyped five single nucleotide polymorphisms (SNPs within the CHIP gene. We first compared the frequencies of the different genotypes in two subgroups of patients who were highly discordant for AO after correction for the length of the expanded CAG allele. The possible modifier effect of each gene was then evaluated in a stepwise multiple linear regression model. Results: AO was associated with the length of the expanded CAG allele (r2 = 0.596, p<0.001. Frequencies of the normal CAG repeats at the ATXN3 gene and of CHIP polymorphisms did not differ significantly between groups with highly discordant ages at onset. However, addition of the normal allele improved the model fit for prediction of AO (r2 = 0.604, p=0.014. Indeed, we found that the normal CAG allele at ATXN3 had a positive independent effect on AO. Conclusion: The normal CAG repeat at the ATXN3 gene has a small but significant influence on AO of MJD.

  8. Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.

    Science.gov (United States)

    Carmona, Vitor; Cunha-Santos, Janete; Onofre, Isabel; Simões, Ana Teresa; Vijayakumar, Udaya; Davidson, Beverly L; Pereira de Almeida, Luís

    2017-04-05

    Machado-Joseph disease (MJD) is a genetic neurodegenerative disease caused by an expanded polyglutamine tract within the protein ataxin-3 (ATXN3). Despite current efforts, MJD's mechanism of pathogenesis remains unclear and no disease-modifying treatment is available. Therefore, in this study, we investigated (1) the role of the 3' UTR of ATXN3, a putative microRNA (miRNA) target, (2) whether miRNA biogenesis and machinery are dysfunctional in MJD, and (3) which specific miRNAs target ATXN3-3' UTR and whether they can alleviate MJD neuropathology in vivo. Our results demonstrate that endogenous miRNAs, by targeting sequences in the 3' UTR, robustly reduce ATXN3 expression and aggregation in vitro and neurodegeneration and neuroinflammation in vivo. Importantly, we found an abnormal MJD-associated downregulation of genes involved in miRNA biogenesis and silencing activity. Finally, we identified three miRNAs-mir-9, mir-181a, and mir-494-that interact with the ATXN3-3' UTR and whose expression is dysregulated in human MJD neurons and in other MJD cell and animal models. Furthermore, overexpression of these miRNAs in mice resulted in reduction of mutATXN3 levels, aggregate counts, and neuronal dysfunction. Altogether, these findings indicate that endogenous miRNAs and the 3' UTR of ATXN3 play a crucial role in MJD pathogenesis and provide a promising opportunity for MJD treatment. Copyright © 2017 The American Society of Gene and Cell Therapy. All rights reserved.

  9. Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype.

    Science.gov (United States)

    Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; Lima, Maria C; Manjunath, N; Pereira de Almeida, Luís

    2016-03-01

    Others and we showed that RNA interference holds great promise for the treatment of dominantly inherited neurodegenerative disorders such as Machado-Joseph disease (MJD), for which there is no available treatment. However, successful experiments involved intracranial administration of viral vectors and there is a need for a safer and less invasive procedure. In this work, we successfully generated stable nucleic acid lipid particles (SNALPs), incorporating a short peptide derived from rabies virus glycoprotein (RVG-9r) and encapsulating small interfering RNAs (siRNAs), which can target mutant ataxin-3. The developed formulation exhibited important features that make it adequate for systemic administration: high encapsulation efficiency of siRNAs, ability to protect the encapsulated siRNAs, appropriate and homogeneous particle size distribution. Following optimization of the formulation and in vitro validation of its efficacy to silence the MJD-causing protein - mutant ataxin-3 - in neuronal cells, in vivo experiments showed that intravenous administration of RVG-9r-targeted SNALPs efficiently silenced mutant ataxin-3 reducing neuropathology and motor behavior deficits in two mouse models of MJD. To our knowledge, this is the first report showing beneficial impact of a non-viral gene silencing strategy in MJD and the first time that a non-invasive systemic administration proved to be beneficial on a polyglutamine disorder. Our study opens new avenues towards MJD therapy that can also be applied to other neurodegenerative diseases linked to the production of pathogenic proteins. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Spinocerebellar ataxia type 3/Machado-Joseph disease: segregation patterns and factors influencing instability of expanded CAG transmissions.

    Science.gov (United States)

    Souza, G N; Kersting, N; Krum-Santos, A C; Santos, A S P; Furtado, G V; Pacheco, D; Gonçalves, T A; Saute, J A; Schuler-Faccini, L; Mattos, E P; Saraiva-Pereira, M L; Jardim, L B

    2016-08-01

    Controversies about Mendelian segregation and CAG expansion (CAGexp) instabilities during meiosis in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) need clarification. Additional evidence about these issues was obtained from the cohort of all SCA3/MJD individuals living in South Brazil. A survey was carried out to update information registered since 2001. Deaths were checked with the Public Information System, and data was made anonymous. Anticipation and delta-CAGexp from parent-offspring pairs, and delta-CAGexp between siblings were obtained. One hundred and fifty-nine families (94% of the entire registry) were retrieved, comprising 3725 living individuals as of 2015, 625 of these being symptomatic. Minimal prevalence was 6:100,000. Carriers of a CAGexp represented 65.6% of sibs in the genotyped offspring (p < 0.001). Median instability was larger among paternal than maternal transmissions, and instabilities correlated with anticipation (r = 0.38; p = 0.001). Age of the parent correlated to delta-CAGexp among 115 direct parent-offspring CAGexp transmissions (ρ = 0.23, p = 0.014). In 98 additional kindreds, the delta-CAGexp between 269 siblings correlated with their delta-of-age (ρ = 0.27, p < 0.0001). SCA3/MJD was associated with a segregation distortion favoring the expanded allele in our cohort. Instability of expansion during meiosis was weakly influenced by the age of the transmitting parent at the time of conception. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Psychosis in Machado-Joseph Disease: Clinical Correlates, Pathophysiological Discussion, and Functional Brain Imaging. Expanding the Cerebellar Cognitive Affective Syndrome.

    Science.gov (United States)

    Braga-Neto, Pedro; Pedroso, José Luiz; Gadelha, Ary; Laureano, Maura Regina; de Souza Noto, Cristiano; Garrido, Griselda Jara; Barsottini, Orlando Graziani Povoas

    2016-08-01

    Machado-Joseph disease (MJD) is the most common spinocerebellar ataxia worldwide with a broad range of clinical manifestations, but psychotic symptoms were not previously characterized. We investigated the psychiatric manifestations of a large cohort of Brazilian patients with MJD in an attempt to characterize the presence of psychotic symptoms. We evaluated 112 patients with clinical and molecular diagnosis of MJD from February 2008 to November 2013. Patients with psychotic symptoms were referred to psychiatric evaluation and brain perfusion single-photon emission computed tomography (SPECT) analysis. A specific scale-Positive and Negative Syndrome Scale (PANSS)-was used to characterize psychotic symptoms in MJD patients. We also performed an autopsy from one of the patients with MJD and psychotic symptoms. Five patients presented psychotic symptoms. Patients with psychotic symptoms were older and had a late onset of the disease (p < 0.05). SPECT results showed that MJD patients had significant regional cerebral blood flow (rCBF) decrease in the cerebellum bilaterally and vermis compared with healthy subjects. No significant rCBF differences were found in patients without psychotic symptoms compared to patients with psychotic symptoms. The pathological description of a patient with MJD and psychotic symptoms revealed severe loss of neuron bodies in the dentate nucleus and substantia nigra. MJD patients with a late onset of the disease and older ones are at risk to develop psychotic symptoms during the disease progression. These clinical findings may be markers for an underlying cortical-cerebellar disconnection or degeneration of specific cortical and subcortical regions that may characterize the cerebellar cognitive affective syndrome.

  12. Double-blind crossover trial of trimethoprim-sulfamethoxazole in spinocerebellar ataxia type 3/Machado-Joseph disease.

    Science.gov (United States)

    Schulte, T; Mattern, R; Berger, K; Szymanski, S; Klotz, P; Kraus, P H; Przuntek, H; Schöls, L

    2001-09-01

    To evaluate the efficiency of a combination of trimethoprim and sulfamethoxazole in patients with spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). Placebo-controlled, double-blind crossover trial in 22 patients with genetically confirmed SCA3/MJD. Study phases of 6 months were separated by a washout period of 4 weeks. Dosages were a combination of trimethoprim, 160 mg, and sulfamethoxazole, 800 mg, twice daily for 2 weeks, followed by a combination of trimethoprim, 80 mg, and sulfamethoxazole, 400 mg, twice daily for 5.5 months. Outpatient department of the Neurological Clinic, Ruhr-University, Bochum, Germany. Ataxia ranking scale, self-assessment score, static posturography, and results of motor performance testing. Effects on the visual system were studied using the achromatic Vision Contrast Test System and the Farnsworth-Munsell 100-hue test for color discrimination. Physical and mental health were documented using the Medical Outcomes Study 36-Item Short-Form Health Survey. Subgroup analyses assessed the influence of age, sex, age at onset, duration of the disease, phenotype, and CAG repeat length on test performance. Twenty of 22 patients completed the study. Dropouts were due to a rash (placebo phase) and an attempted suicide in a family conflict. Trimethoprim-sulfamethoxazole therapy had no significant effect in SCA3/MJD patients in the short-term analysis (2 weeks) or in the long-term interval (6 months). In contrast to previous reports that studied smaller groups of patients, treatment with trimethoprim-sulfamethoxazole did not improve the diverse and complex movement disorders caused by SCA3/MJD. Trimethoprim-sulfamethoxazole had no effect on the visual system and cannot be recommended as a continuous treatment for SCA3/MJD patients.

  13. Catholic Enlightenment for children. Teaching religion to children in the Habsburg Empire from Joseph II to the Restoration

    Directory of Open Access Journals (Sweden)

    Simonetta Polenghi

    2016-05-01

    Full Text Available During Joseph II’s reign a deep cultural shift took place within the intellectual and religious establishment, with the acceptance of philosophical and pedagogical ideas that bore a distinctive Enlightenment and Protestant stamp. This cultural shift was applied to the teaching of religion by some relevant figures of the episcopal and pedagogical elites (J. A. Gall, F.M. Vierthaler, F. de Paula Gaheis, J. M. Leonhard. New handbooks and textbooks of the catechism were written which introduced new dialogic methods, more narrative, and borrowed Rochow’s typology of moral short stories. The content of Bishop Gall’s books was heavily rationalistic, whereas subsequent texts tried to balance reason and faith. Vierthaler, Gaheis, and Leonhard used a language that was more suitable for children and closer to the New Testament, with the use of parables and short stories. The so-called Socratic method was used in different ways by these authors.In the age of the Restoration, in spite of the process of school confessionalization, the heritage of the spirit of Enlightenment was still present, since by law the pedagogy taught in the Empire’s academic chairs and teacher training courses was the one defined by Milde, which bore a Kantian imprint, and stressed the importance of developing inner moral law in pupils. Leonhard was a follower of Milde, and his catechism, eventually approved for elementary schools for decades, bore this stamp.So at the end of the eighteenth and the beginning of the nineteenth centuries a new way of teaching religion was introduced, debated and contested in Habsburg Catholic territories. Rousseau’s and Salzmann’s theories were discussed; rationalism and faith, natural religion and revelation were confronted. In the end more attention was devoted to child psychology and language. The cultural fracture caused by Josephinism became less severe: orthodoxy was restored, but new pedagogical ideas actually entered the teaching of

  14. “When Joseph awoke, he did as the angel of the Lord had commanded him” (Mt 1 : 24. Discreet, Effective Service

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    Tomasz Maria Dąbek

    2013-03-01

    Full Text Available Saint Joseph was a righteous man. He respected the Law of Israel. The decision to divorce Mary after she was found with child was not an easy one, although he knew he was not the child’s father. Instructed by the angel of the Lord, he took her to his home, gave a name to her child as his legal guardian (Mt 1 : 18–25, took care of his wife and her child, organised their trip to Egypt (Mt 2 : 13–15, then their return to Palestine and life in Nazareth (Mt 2 : 19–23; cf. Lk 2 : 39–52. His active obedience to God is the fulfilment of all the things Saint James will later describe as faith shown by the works of the faithful (Jas 2 : 14–17. 20–26. Joseph is put among those who bear witness to the faith of the Old Testament. The Gospels give no account of his exact words, although he fulfilled everything that he had been commanded. Saint Joseph can be a patron of everyone who tries to fulfil God’s will in a discreet and effective manner, with perseverance produced by faith (cf. Jas 1 : 3f.. With his works and life he shows how to bridle your tongue (cf. Jas 1 : 26f.; 3 : 1–13 and take care of the ones that need it the most (cf. Jas 1 : 27; 3 : 13, discreetly fulfilling your duties.

  15. The cosmic child: The artwork of Joseph Cornell and a type of unusual sensibility, or thinking inside the box: the mind that channels infinity.

    Science.gov (United States)

    Scheftel, Susan

    2009-01-01

    This paper explores the unique mind of the twentieth- century American artist Joseph Cornell, known for his boxes and collages made with "found" materials. The author interpolates reflections upon Cornell with vignettes from the treatment of a young child, speculating that certain individuals may possess a constellation of vulnerabilities/sensitivities that constitute what is referred to as a "cosmic" sensibility. It is suggested that such an orientation can lead variously to anxieties and separation problems, as well as (or in addition to) intellectual and/or artistic giftedness. The outcome of such dynamics would depend on a complex interplay of temperament, circumstance, and relational attunement.

  16. Review on “Reich of the black sun. Nazi secret weapons & the cold war allied legend” by Joseph P. Farrell

    Directory of Open Access Journals (Sweden)

    Malugin Sergey Borisovich

    2013-11-01

    Full Text Available Joseph Farrell thinks that during World War II Nazi Germany has created and successfully tested, and could have even used the plutonium bomb in a combat situation. Also it is likely that German scientists managed to make a significant step towards the creation – if not the testing – of a bomb constructed by a method of accelerated division, a bomb that has a small critical mass and a great devastating effect. This statement, however radical it may seem, in author’s opinion, can resolve many inconsistencies and contradictions in political and strategic history of the war.

  17. Machado-Joseph Disease

    Science.gov (United States)

    ... and is characterized as much by peripheral neuromuscular involvement (muscle twitching, weakness, atrophy, and abnormal sensations such ... to undergo this test out of concern for job discrimination and difficulty in obtaining or maintaining insurance, ...

  18. Machado-Joseph Disease

    Science.gov (United States)

    ... trouble swallowing can be treated with medication and speech therapy. Physiotherapy can help patients ... ataxia (ataxia is a medical term meaning lack of muscle control). The disease is characterized ...

  19. Joseph Slaughter, Lettura umanitaria

    Directory of Open Access Journals (Sweden)

    Sostene Zangari

    2011-07-01

    Full Text Available Nell’ambito della discussione sulle potenzialità della lettura e dello studio letterario come strumento di alfabetizzazione nei diritti umani, il saggio intende proporre un’alternativa alle strategie di lettura proposte da Richard Rorty e Martha Nussbaum, le quali pongono l’accento sull’identificazione tra lettore e vittime. Prendendo a oggetto di analisi Un ricordo di Solferino, opera di Henry J. Dunant, il saggio esplora la possibilità di identificazione tra lettore e il volontario impegnato nella cura dei feriti e dei bisognosi, sostituendo all’empatia metaforica proposta da Rorty e Nussbaum un rapporto metonimico di contiguità. La sostituzione consente di superare la divisione lettore/vittima, che ripropone una relazione asimmetrica di potere tra l’Occidente e il resto del mondo, e avviare un discorso diretto a tutta l’umanità senza distinzione.

  20. Remarks of Joseph Marrone

    International Nuclear Information System (INIS)

    Marrone, J.

    1985-01-01

    The author's remarks are directed primarily at proposals that have been made that would substantially tort law with respect to radiation claims in order to ease the ability of claimants to recovery damages from defendants. The change would be based upon what had been assumed to be a ''scientific'' means of measuring the ''probability'' that exposure to ionizing radiation was the case of a cancer in a particular claimant. The remarks are divided into three parts: a summary description of the nuclear insurance pools, including the tort radiation claims filed against the pools; and a brief description of claims against the Federal Government and its contractors; an examination of the elementary principles of tort law, and an outline of the threat that has developed that would transform it into a hybrid social benefits program; and comment on the danger to the integrity of science when it is injected into the legislative process

  1. DELOS Joseph-Thomas

    OpenAIRE

    Monnet, Marie

    2016-01-01

    Né le 7 août 1891 à Ham-en-Artois (Pas-de-Calais), mort le 10 janvier 1974 à Paris (Seine).Professeur de droit et de sociologie à l’Université catholique de Lille (1924-1940), à la faculté de sciences sociales de l’Université Laval (Québec) et à la New School for Social Research de New York (États-Unis) (1941-1945) ; présent à Alger, lors de la constitution du gouvernement provisoire de la République française (1er avril-29 septembre 1944) ; docteur honoris causa de l’Université Laval (1953),...

  2. A giant urinary bladder stone in the mummy of Lebanese Maronite Patriarch Joseph Tyan (1760–1820) and its environmental and nutritional implications

    International Nuclear Information System (INIS)

    Capasso, L.; Licata, M.; Pinto, A.; Fernianos, F.; Azizi, T.; Manzoli, L.; Centrella, D.; D'anastasio, R.

    2017-01-01

    Introduction: Historical sources and anthropological investigations, with the indispensable support of radiology, bring to light pathological evidence of the past. Case presentation: The purpose of this article is to present the radiological investigation conducted on the mummy of the Maronite Joseph Tyan (1760–1820), a famous patriarch who guided the Lebanese Maronite community during a critical period of its history. The natural mummy of the Patriarch was temporarily removed from its burial site to certify the degree of preservation. Conventional radiography was necessary to determine the state of the internal organs and any physical abnormalities, and to clarify the degree of conservation of the mummy. Discussion: Radiological analysis uncovered an exceptional case of a large urinary bladder stone. This pathological evidence confirms historical documentary sources that in the last years of his life the Patriarch suffered from abdominal pain and urinary problems. We can suppose that the environment and diet of the Maronite community, limited by restricted agricultural resources, was the possible cause of the urinary bladder stone, as today the epidemiology of these diseases demonstrates links with mainly cereal diets in rural areas. - Highlights: • Paleoradiological analysis: a radiological approach to study mummies. • The anthropological and radiological analysis of the Mummy of Patriarch Joseph Tyan • Urinary bladder stone: radiological investigations. • Paleopathological literature of urinary bladder stone.

  3. Dimensões comunicacionais no conceito de escultura social de Joseph Beuys como possibilidade de tradução criativa.

    Directory of Open Access Journals (Sweden)

    Magda Salete Vicini

    Full Text Available O presente artigo é resultado de pesquisa de doutorado em Comunicação e Semiótica, realizada na PUC-SP, sobre o conceito de Escultura Social na obra de Joseph Beuys, com recorte em pesquisadores como Matthias Bunge e Caroline Tisdall, bem como a influência dos filósofos românticos Schiller, Goethe, Hegel e de Novalis na construção deste conceito na obra de Rudolf Steiner. O contexto da arte é abordado através de críticos de arte que analisam o trabalho artístico de Beuys, cujas características comunicacionais são apresentadas em relação a Humberto Maturana e Francisco Varella e à crítica da comunicação. Finalmente, o artigo aborda a possibilidade de tradução criativa (Walter Benjamin, Georg Steiner e Haroldo de Campos deste conceito de Joseph Beuys.

  4. ‘A man of great feeling and sensibility’: The Memoirs of Joseph Grimaldi and the Tears of a Clown

    Directory of Open Access Journals (Sweden)

    Jonathan Buckmaster

    2011-09-01

    Full Text Available In the ‘Concluding Chapter’ of his 'Memoirs of Joseph Grimaldi' (1838, Charles Dickens describes Grimaldi as ‘a man of great feeling and sensibility’, despite the fact that he thinks ‘many readers will ridicule the idea’ of a clown being capable of such emotional depth. But here Dickens is not merely a traditional biographer, summarizing the evidence and using it as the basis for an evaluation of his subject’s life. In fact, this is the carefully crafted conclusion of a narrative deliberately constructed to tell the life story of ‘a man of the kindest heart’.   The level of Dickens’s creative input in the 'Memoirs' has always been a matter for debate, but in a letter to Grimaldi’s doctor, Dickens explains how he directly shaped the way that Grimaldi’s emotional side was presented. Despite claiming his role as a mere editor, Dickens admits that ‘I was very much struck by the many traits of kindheartedness scattered through the book, and have given it that colouring throughout’, clearly signalling his focus on the sentimental side of Grimaldi’s character.   In the first section of this article, I demonstrate how Dickens provides that colouring through his shaping of the biographical material, and reconstructs Grimaldi as a real-life counterpart to Dickens’s extremely popular character of time, Mr Pickwick. Through his choice of incidents from Grimaldi’s life, and the way in which he presents the choices and actions Grimaldi takes, Dickens attempts to offer Grimaldi as an admirable model of feeling towards his fellow man.   However, in the second section of this article, I show how this biographical imperative to show Grimaldi as a man of feeling is counterposed by a contesting narrative. This second narrative is the work of the more creative writer within Dickens, and like his earlier essay ‘The Pantomime of Life’ (March 1837 it posits identity as being based on external performance and affect rather than

  5. Qualidade de vida em pacientes com doença de Machado-Joseph sob acompanhamento fonoaudiológico para disfagia

    Directory of Open Access Journals (Sweden)

    Bibiana Fuzer da Silva

    Full Text Available RESUMO A doença de Machado-Joseph é uma doença degenerativa e atualmente considerada a ataxia espinocerebelar mais frequente. O processo degenerativo da doença afeta diferentes regiões e funções do sistema nervoso central e/ou periférico. A disfagia é um dos sintomas presentes na doença de Machado-Joseph, sendo responsável pelas complicações clínicas e pela pneumonia aspirativa, sua principal causa de morte. O objetivo deste trabalho é verificar o impacto da terapia fonoaudiológica na qualidade de vida em pacientes com doença de Machado-Joseph. Participaram da pesquisa quatro pacientes diagnosticados com a doença, três do sexo feminino e um do sexo masculino, com média de idade de 46,5 anos (±18 e queixa de disfagia. Na primeira sessão, todos os pacientes responderam ao questionário de Avaliação da Qualidade de Vida em Disfagia, SWAL-QOL, foram avaliados quanto aos aspectos estruturais e funcionais da deglutição e classificados de acordo com a Escala Funcional de Ingestão por Via Oral (FOIS. Após seis sessões de tratamento fonoaudiológico, realizaram nova avaliação clínica da deglutição, novamente classificados de acordo com a escala FOIS e responderam o SWAL-QOL. Conclusões: Após a intervenção fonoaudiológica, todos os pacientes apresentaram melhor conceito nos domínios medo de alimentar-se, alimentação como um fardo e fadiga, podendo-se inferir que houve uma melhora na satisfação com o processo alimentar e, consequentemente, qualidade de vida dos sujeitos acompanhados.

  6. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2004-2005 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R.; McKinstry, C.; Cook, C. [Pacific Northwest National Laboratory

    2005-02-01

    This report documents a four-year study(a) to assess the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee (Oncorhynchus nerka kennerlyi) and rainbow trout (O. mykiss) at the entrance to the forebay of the third powerplant at Grand Coulee Dam. The work was conducted for the Bonneville Power Administration, U.S. Department of Energy, by Pacific Northwest National Laboratory (PNNL) in conjunction with the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes). In this report, emphasis is placed on the methodology and results associated with the fourth project year and compared with findings from the previous years to provide an overall project summary. Since 1995, the Colville Confederated Tribes have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power and Conservation Council Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph dams on the Columbia River (Figure S.1). A 42-month investigation from 1996 to 1999 determined that from 211,685 to 576,676 fish, including kokanee and rainbow trout, were entrained annually at Grand Coulee Dam. Analysis of the data found that 85% of the total entrainment occurred at the dam's third powerplant. Because these entrainment rates represent a significant loss to the tribal fisheries upstream of the dam, they have been judged unacceptable to fishery managers responsible for perpetuating the fishery in Lake Roosevelt. In an effort to reduce fish entrainment rates, the scope of work for the Chief Joseph Kokanee Enhancement Project was modified in 2001 to include a multiyear study of the efficacy of using strobe lights to deter fish from entering the third powerplant forebay. Pacific Northwest National Laboratory initiated the four-year study in collaboration with Colville

  7. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2002-2003 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R.; McKinstry, C.; Simmons, C. (Pacific Northwest National Laboratory)

    2003-01-01

    Since 1995, the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes) have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation concluded that entrainment at Grand Coulee Dam ranged from 211,685 to 576,676 fish annually. Further analysis revealed that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the second year of the study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory. The 2002 study period extended from May 18 through July 30. The objective of the study was to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout. The prototype system consisted of six strobe lights affixed to an aluminum frame suspended vertically underwater from a barge secured in the center of the entrance to the third powerplant forebay. The lights, controlled by a computer, were aimed to illuminate a specific region directly upstream of the barge. Three light level treatments were used: 6 of 6 lights on, 3 of 6 lights on, and all lights off. These three treatment conditions were applied for an entire 24-hr day and were randomly assigned within a 3-day block throughout the study period. A seven

  8. Joseph Priestley Across Theology, Education, and Chemistry: An Interdisciplinary Case Study in Epistemology with a Focus on the Science Education Context

    Science.gov (United States)

    de Berg, Kevin C.

    2011-07-01

    This paper discusses the findings of a search for the intellectual tools used by Joseph Priestley (1733-1804) in his chemistry, education, and theology documents. Priestley's enquiring democratic view of knowledge was applicable in all three areas and constitutes a significant part of his lifework. Current epistemological issues in science education are examined from the point of view of the nature of theory and experiment as observed in Priestley's writings and as espoused in modern philosophy of science. Science and religious faith issues in the context of science education are examined from the point of view of one's understanding of sacred texts, and the suggestion is made that a Priestleyan model of "the liberty to think for oneself" and "to hold knowledge with humility and virtue" could prove helpful in dealing with the known divergent opinions in relation to science, education, and religion.

  9. Romantic Joseph Lenné Landscape Park in Zatonie Near Zielona Góra as a Relic of Garden Art - Modern-Day Transformations and Threats

    Science.gov (United States)

    Kochańska, Agnieszka

    2016-09-01

    The romantic landscape park was established in 1824 by order of one of the best-known aristocrats at the time, Princess Dorothea Talleyrand Perigold, Dutchess of Dino. The park is an example of amenity horticulture of artistic value that has survived to this day. The creator of the park was the talented landscape architect Peter Joseph Lenné. In its current state, the park differs significantly from the image on lithographs of the past. Upon carrying out field investigations and comparative studies, it was established that the maintained stand of tress holds high compositional value. The conclusions of the article define the current threats to the longevity of the park as well as highlighting the plan of revalorization works.

  10. A STUDY ON JOSEPH CONRAD’S HEART OF DARKNESS, LORD JIM AND NOSTROMO İN A NEW HISTORICIST PERSPECTIVE

    OpenAIRE

    ZENGİN, Mevlüde

    2008-01-01

    ÖZET Bu doktora tezinin amacı Joseph Conrad’ın Heart of Darkness (Karanlığın Yüreği) (1898), Lord Jim (1901) ve Nostromo (1904) adlı romanlarını Yeni Tarihselcilik (New Historicism) bağlamında incelemektir. Bu çalışma, adı geçen romanlarla tarihsel bağlam arasındaki ilişkiyi incelemek üzere romanların öncelikle Conrad’ın yaşamı ile daha sonra ise romanların emperyalizm döneminin söylemleri içindeki yerini belirlemek üzere, yazıldığı tarihsel dönem ve aynı dönemde yazılan yazınsal olmayan meti...

  11. História da química e da geologia: Joseph Black e James Hutton como referências para educação em ciências History of chemistry and geology: Joseph Black and James Hutton as references for science education

    Directory of Open Access Journals (Sweden)

    Natalina Aparecida L. Sicca

    2002-07-01

    Full Text Available The second half of eighteenth century is marked by the advancement of chemistry and geology. The first science acquired the law of conservation of mass and this science represented a important support to geology and mineralogy. We say that both became modern science that time. Our aim is to show up some interrelations between history of chemistry and history of geology by means of the study of Joseph Black's and James Hutton's works. We defend that it is positive to science education to understand and approach the relations among different and disciplinary areas of science.

  12. THE CONSTITUTIONAL ISSUE OF CROWNING IN CROATIANHUNGARIAN LAW (THE 150TH ANNIVERSARY OF THE EMPEROR FRANZ JOSEPH I CORONATION FOR THE KING OF HUNGARY AND CROATIA

    Directory of Open Access Journals (Sweden)

    László Heka

    2017-12-01

    Full Text Available This year marks the 150th anniversary of the Coronation of Franz Joseph l as the King of Hungary and Croatia which was marked by the Hungarian side as the condition of reconciliation with Vienna and the conclusion of the Austro-Hungarian settlement. This compromise between Austria and Hungary has served as a template for a yearlong Croatian-Hungarian settlement in many segments. With these two settlements, the Hungarians settled their relations with the court and with the Triune Kingdom of Croatia, Slavonia and Dalmatia, with whom Hungary had been in the state community since 1102. This event marked the end of a long-standing conflict with Austria, and the Croatian issue was removed from the agenda in Budapest and Vienna. In the course of eight centuries of the common statehood, the Coronation was one of the pivotal constitutional questions. The act of the Coronation, which gave the King legitimacy, consisted of the church ritual (anointing and the secular part manifested in taking the oath, and it had a public character and meaning. The latter was reflected in the fact that the crown oath and crown vow (the diplomas of inauguration were considered the contract between the people and the King, and therefore the Crown Defender had a constitutional character. The King got his legitimacy only if he was crowned with the crown of St. Stephen (the Holy Crown, so Franz Joseph l became the Hungarian and Croatian King only after the crowning in Buda. Since the palatine function was incomplete at the time, Hungary had to be represented by Count Gyula Andrassy, who was then the president of the government. After the King’s death in 1916, during the last royal Coronation, a political-legal debate was raised about whether Hungary should be represented by the Prime Minister or other person on behalf of the people.

  13. Chief Joseph Kokanee Enhancement Project : Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at Grond Coulee Dam Third Powerplant Forebay.

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, M.A.; McKinstry, C.A.; Simmons, C.S.

    2002-01-01

    Since 1995, the Colville Confederated Tribes have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council's (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation concluded that entrainment at Grand Coulee Dam ranged from 211,685 to 576,676 fish annually. Further analysis revealed that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC's Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the first year of the study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory (PNNL). The objective of the study was to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout. Analysis of the effect of strobe lights on the distribution (numbers) and behavior of kokanee and rainbow trout was based on 51, 683 fish targets detected during the study period (June 30 through August 1, 2001). Study findings include the following: (1) Analysis of the count data indicated that significantly more fish were present when the lights were on compared to off. This was true for both the 24-hr tests as well as the 1-hr tests. Powerplant discharge, distance from lights, and date were significant factors in the analysis. (2) Behavioral results indicated that fish within 14 m of the lights were trying to avoid the lights by swimming across the lighted

  14. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at the Grand Coulee Dam Third Powerplant Forebay, 2003-2004 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, M.; McKinstry, C.; Cook, C.

    2004-01-01

    Since 1995, the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes) have managed the Chief Joseph Kokanee Enhancement Project as part of the Northwest Power Planning Council (NWPPC) Fish and Wildlife Program. Project objectives have focused on understanding natural production of kokanee (a land-locked sockeye salmon) and other fish stocks in the area above Grand Coulee and Chief Joseph Dams on the Columbia River. A 42-month investigation from 1996 to 1999 determined that from 211,685 to 576,676 fish were entrained annually at Grand Coulee Dam. Analysis of the entrainment data found that 85% of the total entrainment occurred at the dam's third powerplant. These numbers represent a significant loss to the tribal fisheries upstream of the dam. In response to a suggestion by the NWPPC Independent Scientific Review Panel, the scope of work for the Chief Joseph Kokanee Enhancement Project was expanded to include a multiyear pilot test of a strobe light system to help mitigate fish entrainment. This report details the work conducted during the third year of the strobe light study by researchers of the Colville Confederated Tribes in collaboration with the Pacific Northwest National Laboratory. The objective of the study is to determine the efficacy of a prototype strobe light system to elicit a negative phototactic response in kokanee and rainbow trout under field conditions. The prototype system consists of six strobe lights affixed to an aluminum frame suspended 15 m vertically underwater from a barge secured in the center of the entrance to the third powerplant forebay. The lights, controlled by a computer, illuminate a region directly upstream of the barge. The 2003 study period extended from June 16 through August 1. Three light treatments were used: all six lights on for 24 hours, all lights off for 24 hours, and three of six lights cycled on and off every hour for 24 hours. These three treatment conditions were assigned randomly

  15. Monsters and the case of L. Joseph: André Feil's thesis on the origin of the Klippel-Feil syndrome and a social transformation of medicine.

    Science.gov (United States)

    Belykh, Evgenii; Malik, Kashif; Simoneau, Isabelle; Yagmurlu, Kaan; Lei, Ting; Cavalcanti, Daniel D; Byvaltsev, Vadim A; Theodore, Nicholas; Preul, Mark C

    2016-07-01

    André Feil (1884-1955) was a French physician best recognized for his description, coauthored with Maurice Klippel, of patients with congenital fusion of cervical vertebrae, a condition currently known as Klippel-Feil syndrome. However, little is known about his background aside from the fact that he was a student of Klippel and a physician who took a keen interest in describing congenital anomalies. Despite the relative lack of information on Feil, his contributions to the fields of spinal disease and teratology extended far beyond science to play an integral role in changing the misguided perception shrouding patients with disfigurements, defects, deformities, and so-called monstrous births. In particular, Feil's 1919 medical school thesis on cervical abnormalities was a critical publication in defying long-held theory and opinion that human "monstrosities," anomalies, developmental abnormalities, and altered congenital physicality were a consequence of sinful behavior or a reversion to a primitive state. Indeed, his thesis on a spinal deformity centering on his patient, L. Joseph, was at the vanguard for a new view of a patient as nothing less than fully human, no matter his or her physicality or appearance.

  16. The role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease is doubtful.

    Directory of Open Access Journals (Sweden)

    Qi Zhou

    Full Text Available Machado-Joseph disease (MJD is an inherited neurodegenerative disease caused by an expanded CAG repeat in the ATXN3 gene. Although the principal genetic determinant of the age at onset (AAO is the length of the expanded CAG repeat, the additional genetic contribution of MJD toward the AAO has mostly not yet been clarified. It was recently suggested in two independent studies that apolipoprotein E (APOE might be associated with AAO variability in MJD patients. To identify the potential modifier effect of APOE polymorphisms on the AAO of MJD patients, 403 patients with MJD (confirmed by molecular tests from eastern and southeastern China were enrolled in the present study. CAG repeats in the ATXN3 and APOE polymorphisms were genotyped. Data were analyzed using a statistical package. No contribution of APOE polymorphisms to the variance in disease onset was observed using ANCOVA (F = 0.183, P = 0.947. However, significant effects on the AAO of MJD were found for the normal ATXN3 allele and for the interaction of mutant and normal ATXN3 alleles in a multiple linear regression model (P = 0.043 and P = 0.035, respectively. Our study does not support a role for APOE as a genetic modifier of the AAO of MJD. Additionally, our study presents evidence that the normal ATXN3 allele and its interaction with mutant alleles contribute toward AAO variance in MJD patients.

  17. The SCA1 (Spinocerebellar ataxia type 1 and MJD (Machado-Joseph disease CAG repeats in normal individuals: segregation analysis and allele frequencies

    Directory of Open Access Journals (Sweden)

    Wiezel Cláudia Emília Vieira

    2003-01-01

    Full Text Available Spinocerebellar ataxia type 1 (SCA1 and Machado-Joseph disease (MJD/SCA3 are autosomal dominant neurodegenerative diseases caused by expansions of a CAG trinucleotide repeat in the SCA1 and MJD genes. These expanded sequences are unstable upon transmission, leading to an intergeneration increase in the number of repeats (dynamic mutation. The transmission of the CAG repeat was studied in normal mother-father-child trios, referred for paternity testing (SCA1, n = 367; MJD, n = 879. No segregation distortion was detected. The CAG allele frequencies were determined in 330 unrelated individuals (fathers from couples tested for paternity. The allele frequency distributions did not differ from those previously reported for European populations. The estimated values for the statistic parameters indicating diversity at the SCA1 locus did not differ much from those reported previously for other STRs in the Brazilian population, while those for the MJD locus were close to or higher than the maximum values of previous reports. This shows that SCA1 and MJD are highly informative loci for applications in genetic and population studies and for forensic analysis.

  18. When the second man takes the lead: reflections on Joseph Barnabas and Paul of Tarsus and their relationship in the New Testament

    Directory of Open Access Journals (Sweden)

    C.W. Stenschke

    2010-07-01

    Full Text Available Upon scrutiny Joseph Barnabas, mentioned in the New Testament mainly in the Book of Acts but also elsewhere, emerges as one of the great leaders and mentors in early Christianity. This article offers a biographical sketch of Barnabas with a particular focus on his relationship with Paul. While Barnabas appears to have been the mentor of Paul at an early stage and the leader at the beginning of the first missionary journey, he later on made room for Paul to take the lead while he (Barnabas continued to support Paul faithfully. It seems that much of what Paul later practised in his own mission work and the way he sought for and trained co-workers had its origin in his mentorship by Barnabas. This relationship of Barnabas and Paul provides a case study of how leaders can develop and how relationships may change. The biblical portrait of this relationship addresses several crucial issues in leadership and poses several challenges to those concerned with Christian leadership.

  19. Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease.

    Science.gov (United States)

    Duarte-Silva, S; Silva-Fernandes, A; Neves-Carvalho, A; Soares-Cunha, C; Teixeira-Castro, A; Maciel, P

    2016-01-28

    A major pathological hallmark in several neurodegenerative disorders, like polyglutamine disorders (polyQ), including Machado-Joseph disease (MJD), is the formation of protein aggregates. MJD is caused by a CAG repeat expansion in the ATXN3 gene, resulting in an abnormal protein, which is prone to misfolding and forms cytoplasmic and nuclear aggregates within neurons, ultimately inducing neurodegeneration. Treatment of proteinopathies with drugs that up-regulate autophagy has shown promising results in models of polyQ diseases. Temsirolimus (CCI-779) inhibits the mammalian target of rapamycin (m-TOR), while lithium chloride (LiCl) acts by inhibiting inositol monophosphatase, both being able to induce autophagy. We have previously shown that chronic treatment with LiCl (10.4 mg/kg) had limited effects in a transgenic MJD mouse model. Also, others have shown that CCI-779 had mild positive effects in a different mouse model of the disease. It has been suggested that the combination of mTOR-dependent and -independent autophagy inducers could be a more effective therapeutic approach. To further explore this avenue toward therapy, we treated CMVMJD135 transgenic mice with a conjugation of CCI-779 and LiCl, both at concentrations known to induce autophagy and not to be toxic. Surprisingly, this combined treatment proved to be deleterious to both wild-type (wt) and transgenic animals, failing to rescue their neurological symptoms and actually exerting neurotoxic effects. These results highlight the possible dangers of manipulating autophagy in the nervous system and suggest that a better understanding of the potential disruption in the autophagy pathway in MJD is required before successful long-term autophagy modulating therapies can be developed. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

  20. Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.

    Science.gov (United States)

    Li, Xiaoling; Liu, Hongmei; Fischhaber, Paula L; Tang, Tie-Shan

    2015-09-01

    Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3, SCA3), an autosomal dominant neurological disorder, is caused by an abnormal expanded polyglutamine (polyQ) repeat in the ataxin-3 protein. The length of the expanded polyQ stretch correlates positively with the severity of the disease and inversely with the age at onset. To date, we cannot fully explain the mechanism underlying neurobiological abnormalities of this disease. Yet, accumulating reports have demonstrated the functions of ataxin-3 protein in the chaperone system, ubiquitin-proteasome system, and aggregation-autophagy, all of which suggest a role of ataxin-3 in the clearance of misfolded proteins. Notably, the SCA3 pathogenic form of ataxin-3 (ataxin-3(exp)) impairs the misfolded protein clearance via mechanisms that are either dependent or independent of its deubiquitinase (DUB) activity, resulting in the accumulation of misfolded proteins and the progressive loss of neurons in SCA3. Some drugs, which have been used as activators/inducers in the chaperone system, ubiquitin-proteasome system, and aggregation-autophagy, have been demonstrated to be efficacious in the relief of neurodegeneration diseases like Huntington's disease (HD), Parkinson's (PD), Alzheimer's (AD) as well as SCA3 in animal models and clinical trials, putting misfolded protein clearance on the list of potential therapeutic targets. Here, we undertake a comprehensive review of the progress in understanding the physiological functions of ataxin-3 in misfolded protein clearance and how the polyQ expansion impairs misfolded protein clearance. We then detail the preclinical studies targeting the elimination of misfolded proteins for SCA3 treatment. We close with future considerations for translating these pre-clinical results into therapies for SCA3 patients. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. [Is oral rehydration with nasogastric tube more efficient than rehydration with spoon? Preliminary study in children with non-severe dehydration in Joseph-Raseta-Befelatanana Hospital, Madagascar].

    Science.gov (United States)

    Ravelomanana, T; Rabeatoandro, S; Randrianaivo, N; Ratsimbazafy, A; Raobijaona, H; Barennes, H

    2010-05-01

    Since its recommendation by WHO, Oral Rehydration Solutions (ORS) contributed in reducing the rate of mortality due to acute gastroenteritis. In Madagascar, the rate of lethality imputed to gastroenteritis is about 3%. Rehydration can be performed either by using spoons which reliability is unsure because of parents' potential inobservance and child's refusal, or by nasogastric tube. The nasogastric tube may resolve these obstacles at the hospital. We realized a preliminary study to evaluate the efficacy and the safety of nasogastric tube and spoon administration of the ORS in rehydration of child with moderate post-gastroenteritis dehydration. This is an open comparative study realized in the Pediatric Unit at the Joseph-Raseta-Befelatanana Hospital from the 21 January to 21 May 2008. Main outcomes was the proportion of rehydrated children at 4 hours, other were: failure at 8 hours, duration and volume of SRO, side effects. Fifty-three children from 4-month to 4-year old among 1306 patients were recruited and forty-seven patients were included. Nine patients failed (4 children received ORS by spoon and 5 children by nasogastric tube). The use of spoon was more effective: 62.5% of the patients were rehydrated at the fourth hour versus 39.3% in nasogastric tube group (P = 0.04). Making debit constant presents difficulties in rehydration with nasogastric tube (44.4 %). Tolerance of nasogastric tube is generally good but 16.7% children get out their tube during this study. No ORS' inhalation was observed with both routes. No false passage or tube or ORS rejection was recorded in both techniques. This study shows that using spoon to rehydrate is more effective for the rehydration of moderate dehydration. The use of nasogastric tube needs more surveillance.

  2. Ethno-religious Identities and Cosmopolitan Echoes in John Updike’s ‘Terrorist’ (2006 and Joseph O’Neill’s ‘Netherland’ (2008

    Directory of Open Access Journals (Sweden)

    Pamela Mansutti

    2011-09-01

    Full Text Available Far from offering a cohesive representation of ethnic and racialized individuals after the terrorist attacks of 9/11, US recent fiction on this particular subject navigates otherness in many contradictory ways, ranging from the resistance to represent, or even think, alterity in literary forms to the desire of exploring, if not mastering it through characterization. The novels here examined, John Updike’s Terrorist (2006 and Joseph O’Neill’s Netherland (2008, deal with the long-term aftermath of 9/11 rather than shaping its symptomatic repercussions in the days following the attacks. Yet, Updike and O’Neill pick up on the dualisms that run across early post-9/11 America and represent, though in ways that are at largely at odds, the impossibility for (either naturalized or immigrant ethnic subjects to suture their own identity to the fabric of American society. Theirs are stories of naiveté and exclusion that convey a rather pessimistic vision of multiculturalism in the twenty-first-century US society. In both Updike and O’Neill’s novels, 9/11 has augmented social tensions and racial hatred: on the one hand, mainstream white America appears self-absorbed and depressed, unable to open up fully to the unfit or the different; on the other hand, racialized individuals are depicted in an ambivalent light and are in the end doomed because of their blind and staunch faith, regardless whether it is pinned on Islam or the American dream. This would leave us with a rather bleak picture if it were not for the fact that the “white gazes” that shape the novels cast a benign, sympathetic light on the ethnic characters by turning them into victims of their own intransigence and of even larger systemic forces beyond their control.

  3. ASPO Joseph W. Cullen Memorial Award Lecture. Bridging the clinical and public health perspectives in tobacco treatment research: scenes from a tobacco treatment research career.

    Science.gov (United States)

    Curry, S J

    2001-04-01

    This paper, delivered as the 2000 Joseph W. Cullen Memorial Award Lecture, reviews smoking cessation treatment research conducted over the past 15 years at the Center for Health Studies, Group Health COOPERATIVE: The research program includes assessment, treatment, and health services research that addressed four main questions: (a) What motivates people to quit smoking? (b) Are self-help interventions effective? (c) Can health care benefits impact the utilization of smoking cessation services? and (d) Does smoking cessation impact health care utilization and costs? In the area of motivation for smoking cessation, an intrinsic-extrinsic model of type of motivation for smoking cessation was used to develop and validate a reasons for quitting scale. Results from administration of the scale across different samples of smokers show that higher levels of intrinsic relative to extrinsic motivation predicts successful cessation. A series of five randomized trials of self-help interventions indicate that self-help interventions accompanied by motivational feedback and/or outreach telephone counseling can be effective. However, the same interventions did not improve long-term abstinence rates in non-volunteer samples of smokers. With regard to health care benefits, we find that full coverage of smoking cessation services improves the reach of proven interventions into the general population of smokers with no significant reductions in effectiveness. Furthermore, studies of smoking cessation and health care utilization find that, although quitters have higher initial costs, their costs go down at the same time that those of continuing smokers' begin to accelerate. Cessation appears to reverse a trajectory of higher health care costs.

  4. Analysis of regional cerebral blood flow and distribution volume in Machado-Joseph disease by iodine-123I IMP single photon emission computed tomography

    International Nuclear Information System (INIS)

    Hayashi, Tsunemi; Nakajima, Takashi; Fukuhara, Nobuyoshi

    2001-01-01

    Machado-Joseph disease (MJD) is an autosomal dominant spinocerebellar ataxia. Its clinical features vary greatly in different generations of the same family. Regional cerebral blood flow (rCBF) and distribution volume (V d ) in the pons, cerebellum, and cerebral cortex were measured in 12 patients with MJD by autoradiography (ARG) and the table look-up (TLU) method of iodine-123 IMP ( 123 I-IMP) single photon emission computed tomography (SPECT). Representative cases were as follows: A 46-year-old woman first experienced gait ataxia at age 38. Computed tomography (CT) and magnetic resonance imaging (MRI) showed no atrophy in the pons or cerebellum, but rCBF measured by the 123 I-IMP SPECT ARG method detected hypoperfusion in the pons, and cerebellar vermis and hemisphere. A 76-year-old woman first experienced gait ataxia at age 69. CT and MRI findings showed severe atrophy in the pons, and cerebellar vermis and hemisphere. Moreover, rCBF was decreased in the pons, whereas it was not decreased in the cerebellar vermis and hemisphere. In the pons of patients with MJD, rCBF was markedly decreased regardless of disease severity. Because this SPECT finding for the pons looked like a 'dot', we have called it the 'pontine dot sign'. In the MJD group, rCBF was significantly decreased in the pons (Student's t test, p d was also significantly decreased in the pons (p d for the pons and age at onset (r=0.59, p d in the cerebellar hemispheres and International Cooperative Ataxia Rating Scale (r=0.644, p d obtained by 123 I-IMP SPECT for patients with MJD identified by gene analysis. Our study shows that SPECT measurement of rCBF and V d is useful for understanding the pathophysiology of MJD. (author)

  5. A família Drew de Walworth: um século após a avaliação inicial finalmente o diagnóstico doença de Machado-Joseph The Drew family of Walworth: one century from the first evaluation until the final diagnosis, Machado-Joseph disease

    Directory of Open Access Journals (Sweden)

    Hélio A. Ghizoni Teive

    2004-03-01

    Full Text Available As enfermidades heredo-degenerativas, entre elas as ataxias cerebelares autossômicas dominantes, agora conhecidas como ataxias espinocerebelares (AEC, correspondem a extenso grupo de s com grande heterogeneidade genética. Algumas formas de AEC, em especial a de Machado-Joseph (DMJ, caracteriza-se por acentuada variabilidade de expressão fenotípica intra e inter-familial. Em 1895, na Grã-Bretanha, foi descrita uma família com uma forma autossômica dominante de AEC que viria a ser conhecida como a família Drew de Walworth. Desde sua descrição inicial até 1995, quando do diagnóstico genético final de DMJ, vários membros e gerações desta família foram examinados e seus achados descritos na literatura por famosos neurologistas como Gowers, Stewart, Collier, Kinnier-Wilson, Turner, Worster-Drought, Ferguson, Critchley e Anita Harding. Neste artigo, os autores descrevem a trajetória histórica tortuosa e as discussões sobre os diagnósticos nosológicos propostos no decorrer de um século, com o propósito de mostrar a impressionante e atraente complexidade que envolve este grupo de s neurodegenerativas.Autosomal dominant spinocerebellar ataxia (SCA is an heterogeneous group of neurodegenerative diseases involving cerebellum and its connections. Several forms have already been described, and it seems the most common form of SCA observed among the many series of families described worldwide is SCA3 (Machado-Joseph disease. SCA3 is characterized by a marked phenotypic expression with a wide spectrum of clinical findings including cerebellar ataxia, pyramidal and extrapyramidal (e.g. dystonia, parkinsonism, lower motor neuron syndrome and peripheral neuropathy. The Drew family of Walworth, England, has several affected members seen and described by famous neurologists including Gowers, Stewart, Collier, Kinnier-Wilson, Turner, Worster-Drought, Ferguson, Critchley, and Anita Harding from 1895 to our days. In fact, the final genetic

  6. Joseph Louis Lagrange (1736 - 1813)

    Indian Academy of Sciences (India)

    Lagrange's family had French connections on his father's side and Lagrange always leaned towards his French ancestry. As a youth, he signed as Lodovico LaGrange or. Luigi Lagrange, using the French form of his family name. Although Lagrange's father was in the service of the King of Sardinia, the family was not ...

  7. Nastalo vremja deistvovat / Joseph Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph

    2007-01-01

    Globaalsoojenemisega kaasnevatest ohtudest. Maailma võitlusest sooja kliima tekitatud kahjudega, Ameerika Ühendriikide mahajäämusest. Artikli autor on Ameerika majandusteadlane, Nobeli majanduspreemia laureaat

  8. Joseph Louis Lagrange (1736 - 1813)

    Indian Academy of Sciences (India)

    He was the eldest of eleven children of his parents, but only two of them lived to adulthood. Lagrange's family had French connections on his father's side and Lagrange always leaned towards his French ancestry. As a youth, he signed as Lodovico LaGrange or. Luigi Lagrange, using the French form of his family name.

  9. Mobile Learning in Medical Education: Review | Walsh | Ethiopian ...

    African Journals Online (AJOL)

    Mobile Learning in Medical Education: Review. ... Ethiopian Journal of Health Sciences ... These include high access, low cost, more situated and contextual learning, convenience for the learner, continuous communication and interaction between learner and tutor and between learner and other learners, and the ability to ...

  10. On Evidence and Argument in Phenomenological Research | Walsh ...

    African Journals Online (AJOL)

    Set against a background of calls for evidence-based practice, this paper explores the role of evidence and argument in phenomenological research. Drawing on Smith's (1998) analysis of original argument, the author considers how evidence can be discerned, understood, and communicated, and the resulting kinds and ...

  11. DETAILED FLOOD ZONE REDELINEATION, WALSH COUNTY, NORTH DAKOTA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  12. Mobile Learning in Medical Education: Review | Walsh | Ethiopian ...

    African Journals Online (AJOL)

    Ethiopian Journal of Health Sciences. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 25, No 4 (2015) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Download this PDF file. The PDF file you selected ...

  13. Study Skills for Online Learning | Walsh | Sudan Journal of Medical ...

    African Journals Online (AJOL)

    AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers · about Open Access · Journal Quality.

  14. La razón de ser de la presencia de Joseph Conrad en El sueño del celta de Mario Vargas Llosa e Historia secreta de Costaguana de Juan Gabriel Vásquez

    Directory of Open Access Journals (Sweden)

    Caroline Houde

    2015-07-01

    Full Text Available Este artículo pretende ofrecer un estudio de la influencia actual de la obra de Joseph Conrad en la literatura hispanoamericana a través del análisis de dos novelas: Historia secreta de Costaguana (2007, de Juan Gabriel Vásquez, y El sueño del celta (2010, de Mario Vargas Llosa. En primera instancia, se presenta una visión panorámica del influjo conradiano en la América del siglo XX, tanto por lo que atañe al desarrollo de la crítica poscolonial, como por lo que se relaciona con la representación conradiana del topos de la selva en la narrativa hispanoamericana. Luego, se plantea cómo las dos novelas rememoran ciertos hipotextos conradianos e interrogan el aporte de Conrad a la literatura y al Poscolonialismo.

  15. Fédéralisme, identités nationales et critique des frontières naturelles : Pierre-Joseph Proudhon (1809-1865) géographe des « États-Unis d'Europe »

    OpenAIRE

    Ferretti, Federico; Castleton, Edward

    2016-01-01

    Cet article aborde la question de la « géographicité » de l’œuvre du philosophe et militant Pierre-Joseph Proudhon, dans le cadre des études sur les relations entre géographie et anarchisme, théorie politique dont Proudhon est considéré comme l’un des fondateurs. À partir de ses textes édits et inédits, nous interrogeons le rapport de Proudhon à la géographie, notamment dans la construction de ses approches du fédéralisme et du problème des nationalités. Au sein de l’immense corpus proudhonie...

  16. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at Grand Coulee Dam Third Powerplant Forebay, 2005-2006 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, M.; Johnson, Robert; McKinstry, C. [Pacific Northwest National Laboratory

    2006-03-01

    The construction of Grand Coulee and Chief Joseph dams on the Columbia River resulted in the complete extirpation of the anadromous fishery upstream of these structures. Today, this area is totally dependent upon resident fish resources to support local fisheries. The resident fishing is enhanced by an extensive stocking program for target species in the existing fishery, including kokanee (Oncorhynchus nerka kennerlyi) and rainbow trout (O. mykiss). The kokanee fishery in Lake Roosevelt has not been meeting the return goals set by fisheries managers despite the stocking program. Investigations of physical and biological factors that could affect the kokanee population found predation and entrainment had a significant impact on the fish population. In 1999 and 2000, walleye (Sander vitreum) consumed between 15% and 9%, respectively, of the hatchery kokanee within 41 days of their release, while results from a study in the late 1990s estimated that entrainment at Grand Coulee Dam could account for up to 30% of the total mortality of the stocked fish. To address the entrainment loss, the Bonneville Power Administration commissioned a study to determine if fish would avoid areas illuminated by strobe lights in the forebay of the third powerplant. This work was conducted by Pacific Northwest National Laboratory (PNNL) in conjunction with the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes). From 2002 through 2004, six strobe lights were suspended in the center of the opening to the third powerplant forebay during summer months. Results from those studies indicated that fish appeared to be attracted to the illuminated area but only at night and when flow conditions within the third powerplant forebay were minimal. However, small but consistent results from these studies indicated that under high flow conditions, fish might be avoiding the lights. The 2005 study was designed to examine whether, under high flow conditions near the penstock

  17. Browse Author Index

    African Journals Online (AJOL)

    Items 1 - 50 of 61 ... Walker, L · Walker, Liz · Walraven, Gijs · Walsh, Corinna · Walwyn, David · Wamalwa, David · Wambua, MaryAnne · Wamoyi, Joyce · Wang'ombe, Joseph K · Wanyenze, Rhoda K · Wanzala, Peter N · Washington, Laura · Wathuta, Jane · Watkins, Susan Cotts · Wato, Samuel · Watson, Mada · Watson, Sharon

  18. Using 3D Acoustic Telemetry to Assess the Response of Resident Salmonids to Strobe Lights in Lake Roosevelt, Washington; Chief Joseph Kokanee Enhancement Feasibility Study, Annual Report 2001-2002.

    Energy Technology Data Exchange (ETDEWEB)

    Perry, Russlee; Farley, M.; Hansen, Gabriel

    2003-01-01

    In 1995, the Chief Joseph Kokanee Enhancement Project was established to mitigate the loss of anadromous fish due to the construction of Chief Joseph and Grand Coulee dams. The objectives of the Chief Joseph Enhancement Project are to determine the status of resident kokanee (Oncorhynchus nerka) populations above Chief Joseph and Grand Coulee dams and to enhance kokanee and rainbow trout (Oncorhynchus mykiss) populations. Studies conducted at Grand Coulee Dam documented substantial entrainment of kokanee through turbines at the third powerhouse. In response to finding high entrainment at Grand Coulee Dam, the Independent Scientific Review Panel (ISRP) recommended investigating the use of strobe lights to repel fish from the forebay of the third powerhouse. Therefore, our study focused on the third powerhouse and how strobe lights affected fish behavior in this area. The primary objective of our study was to assess the behavioral response of kokanee and rainbow trout to strobe lights using 3D acoustic telemetry, which yields explicit spatial locations of fish in three dimensions. Our secondary objectives were to (1) use a 3D acoustic system to mobile track tagged fish in the forebay and upriver of Grand Coulee Dam and (2) determine the feasibility of detecting fish using a hydrophone mounted in the tailrace of the third powerhouse. Within the fixed hydrophone array located in the third powerhouse cul-de-sac, we detected 50 kokanee and 30 rainbow trout, accounting for 47% and 45% respectively, of the fish released. Kokanee had a median residence time of 0.20 h and rainbow trout had a median residence time of 1.07 h. We detected more kokanee in the array at night compared to the day, and we detected more rainbow trout during the day compared to the night. In general, kokanee and rainbow trout approached along the eastern shore and the relative frequency of kokanee and rainbow trout detections was highest along the eastern shoreline of the 3D array. However, because we

  19. [Paskal Joseph Ritter von Ferro, the Reformer of the Austrian Public Health. On the occasion of the 200th anniversary of his death in consequence of the battle of Wagram against Napoleon].

    Science.gov (United States)

    Flamm, Heinz

    2009-01-01

    Paskal Joseph Ferro, born on June 5th, 1753 in Bonn, Germany, in the course of his military service as a surgeon graduated medicine in 1777 in Strasbourg and Vienna. Here initially he worked as a private physician in a hospital. In 1785 he became an assistant to the leading municipal physician, in 1793 he was appointed director of the district hospitals and in 1793 medical official in charge of Lower Austria. In 1795 Ferro was the first on the now created position of "Protomedicus" (director of the health administration) of an Austrian country. His most important acts were the creation of the first medical cold water bath in Austria, the foundation of institutions for the salvation of casualties, the introduction of rooms to lay out the dead in the communities, the organization of dispersed health regulations and their publications for common knowledge and especially the introduction of the smallpox vaccination in 1799 first time outside the UK. After the battle of Wagram (north to Vienna) in the Napoleonic war (July 6th, 1809) he had to care for the wounded and 56,000 dead soldiers on the battle field. In this action he contracted typhoid fever and consequently died on August 21st, 1809.

  20. OMICS and 21st century brain surgery from education to practice: James Rutka of the University of Toronto interviewed by Joseph B. Martin (Boston) and Türker Kılıç (İstanbul).

    Science.gov (United States)

    Rutka, James; Martin, Joseph; Kılıç, Türker

    2014-12-01

    The Science-in-Backstage interviews aim to share experiences by global medical and life sciences thought leaders on emergent technologies and novel scientific, medical, and educational practices, situating them in both a historical and contemporary science context so as to "look into the biotechnology and innovation futures" reflexively and intelligently. OMICS systems diagnostics and personalized medicine are greatly impacting brain surgery, not to forget the training of the next generation of neurosurgeons. What do the futures hold for the practice of, and education in 21(st) century brain surgery in the age of OMICS systems science, personalized medicine, and the use of simulation in surgeon training? James Rutka is a clinician scientist and a world leader in diagnosis and treatment of brain tumors. He is Professor and Chair of the Department of Surgery at the Faculty of Medicine, University of Toronto, a President Emeritus of the American Association of Neurological Surgeons, and Editor-in-Chief of the Journal of Neurosurgery. Professor Rutka was interviewed for the global medical, biotechnology, and life sciences readership of the OMICS: A Journal of Integrative Biology to speak on these pressing questions in his personal capacity as an independent senior scholar. The issues debated in the present interview are of broad relevance for 21(st) century surgery and postgenomics medicine. The interviewers were Professor Joseph B. Martin, Harvard Medical School Dean Emeritus in Boston and Joint Dean of Medicine at Bahçeşehir University in İstanbul, and the author of "Alfalfa to Ivy: Memoir of a Harvard Medical School Dean," and Professor Türker Kılıç, Dean of Medicine at Bahçeşehir University in İstanbul, and an elected member of the Turkish Academy of Sciences.

  1. 1355-IJBCS-Article-Joseph B Sawadogo

    African Journals Online (AJOL)

    Administrateur

    au recyclage de la matière organique végétale et à l'humification de l'écosystème terrestre. (Lefebvre, 2008). Compte tenu de leur forte densité, surtout en régions ..... la termitière et l'atmosphère selon le cycle journalier. A cela s'ajoute l'activité des termites pour modifier la structure de leur termitière selon le cycle diurne ou ...

  2. 97 JOSEPH RATZINGER'S THEOLOGICAL HERMENEUTICS FOR ...

    African Journals Online (AJOL)

    HP

    1988-01-27

    Jan 27, 1988 ... Ratzinger‟s views on its inadequacy for sustenance of the Christian faith.21It is important to note that the .... definition, Daniel Treier defines it as “effort to understand the nature of human understanding.”48 Its form ..... 63 I have only made a selection of three of those principles in this paper, details of the ...

  3. 780-IJBCS-Article-Ugye Joseph

    African Journals Online (AJOL)

    DR GATSING

    The dried isolated plasma albumin was further characterized for purity using protein analysis, optical rotation , ... rotation at[α]598. 32 at pH 7.2 of 80 and gradually dissolved in acidified water and ethanol. The plasma albumin was also found to be slightly turbid when dissolved in .... Management and Staff of Federal Medical.

  4. St. Joseph's Community Hospital, Millstreet, Cork.

    LENUS (Irish Health Repository)

    Barker, Maja

    2007-01-01

    BACKGROUND: Self-perceptions of aging have been implicated as independent predictors of functional disability and mortality in older adults. In spite of this, research on self-perceptions of aging is limited. One reason for this is the absence of adequate measures. Specifically, there is a need to develop a measure that is theoretically-derived, has good psychometric properties, and is multidimensional in nature. The present research seeks to address this need by adopting the Self-Regulation Model as a framework and using it to develop a comprehensive, multi-dimensional instrument for assessing self-perceptions of aging. This study describes the validation of this newly-developed instrument, the Aging Perceptions Questionnaire (APQ). METHODS: Participants were 2,033 randomly selected community-dwelling older (+65 yrs) Irish adults who completed the APQ alongside measures of physical and psychological health. The APQ assesses self-perceptions of aging along eight distinct domains or subscales; seven of these examine views about own aging, these are: timeline chronic, timeline cyclical, consequences positive, consequences negative, control positive, control negative, and emotional representations; the eighth domain is the identity domain and this examines the experience of health-related changes. RESULTS: Mokken scale analysis showed that the majority of items within the views about aging subscales were strongly scalable. Confirmatory factor analysis also indicated that the model provided a good fit for the data. Overall, subscales had good internal reliabilities. Hierarchical linear regression was conducted to investigate the independent contribution of APQ subscales to physical and psychological health and in doing so determine the construct validity of the APQ. Results showed that self-perceptions of aging were independently related to physical and psychological health. Mediation testing also supported a role for self-perceptions of aging as partial mediators in the relationship between indices of physical functioning and physical and psychological health outcomes. CONCLUSION: Findings support the complex and multifaceted nature of the aging experience. The good internal reliability and construct validity of the subscales suggests that the APQ is a promising instrument that can enable a theoretically informed, multidimensional assessment of self-perceptions of aging. The potential role of self-perceptions of aging in facilitating physical and psychological health in later life is also highlighted.

  5. Paediatric Malignancies | Joseph | African Journal of Paediatric ...

    African Journals Online (AJOL)

    malignancies. Other common malignancies included sarcomas 10(14.71%), neurofibromatosis 9(13.24%), nephroblastoma 8(11.77%), acute lymphoblastic leukaemia 5(7.35%) and retinoblastoma 4(5.88%). The less common paediatric malignancies were melanoma, invasive lobular breast carcinoma and squamous cell ...

  6. 1618-IJBCS-Article-Djeugap Fovo Joseph

    African Journals Online (AJOL)

    hp

    génotypes par hybridation naturelle dans les zones sympatriques. Ceci peut être possible grâce à une étude ... afin de mesurer le taux d'allogamie et d'hybridation naturelle, la diversité génétique au sein de l'espèce et .... ou interspécifique de la résistance à ces pathologies et de vérifier enfin si cette dernière est d'origine ...

  7. 931-IJBCS-Article-Dossou Joseph

    African Journals Online (AJOL)

    DR GATSING

    Les teneurs en matière sèche et en protéines brutes sont respectivement de 39% et 5,2%, tandis que celles des cendres brutes et des sucres totaux sont estimées à 1,1% et à 3,1%. L'étude a également révélé que la fermentation est assurée par les levures et les bactéries lactiques. Par rapport à sa qualité sanitaire,.

  8. 1507-IJBCS-Article-Joseph Fianko

    African Journals Online (AJOL)

    hp

    4School of Nuclear and Allied Sciences, University of Ghana, Legon, Accra. * Corresponding author, E-mail: jrfianko@yahoo.com ... improper disposal and management of waste (WRC,. 2007). The use of pesticides to control pests ... disposal facilities have caused contamination of soil and water bodies resulting in a rapid.

  9. St. Joseph's Hospital Ardee, Ardee, Louth.

    LENUS (Irish Health Repository)

    Douillard, Francois P

    2010-04-08

    Abstract Background Helicobacter pylori is the causative agent for gastritis, and peptic and duodenal ulcers. The bacterium displays 5-6 polar sheathed flagella that are essential for colonisation and persistence in the gastric mucosa. The biochemistry and genetics of flagellar biogenesis in H. pylori has not been fully elucidated. Bioinformatics analysis suggested that the gene HP0256, annotated as hypothetical, was a FliJ homologue. In Salmonella, FliJ is a chaperone escort protein for FlgN and FliT, two proteins that themselves display chaperone activity for components of the hook, the rod and the filament. Results Ablation of the HP0256 gene in H. pylori significantly reduced motility. However, flagellin and hook protein synthesis was not affected in the HP0256 mutant. Transmission electron transmission microscopy revealed that the HP0256 mutant cells displayed a normal flagellum configuration, suggesting that HP0256 was not essential for assembly and polar localisation of the flagella in the cell. Interestingly, whole genome microarrays of an HP0256 mutant revealed transcriptional changes in a number of genes associated with the flagellar regulon and the cell envelope, such as outer membrane proteins and adhesins. Consistent with the array data, lack of the HP0256 gene significantly reduced adhesion and the inflammatory response in host cells. Conclusions We conclude that HP0256 is not a functional counterpart of FliJ in H. pylori. However, it is required for full motility and it is involved, possibly indirectly, in expression of outer membrane proteins and adhesins involved in pathogenesis and adhesion.

  10. 1197-IJBCS-Article-Joseph Edoga

    African Journals Online (AJOL)

    hp

    Josephat Edoga ONU 1*, Bankole Olusiji OKE 2, Peter Chuka OZEGBE 2 and. Johnson Oluwayemisi OYEWALE 3. 1Department of Veterinary Anatomy, Usmanu Danfodiyo University, Sokoto, Nigeria. 2Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria. 3 Department of ...

  11. St Joseph's Community Hospital, Stranorlar, Donegal.

    LENUS (Irish Health Repository)

    Fan, Ben

    2012-06-21

    AbstractBackgroundPlant root exudates have been shown to play an important role in mediating interactions between plant growth-promoting rhizobacteria (PGPR) and their host plants. Most investigations were performed on Gram-negative rhizobacteria, while much less is known about Gram-positive rhizobacteria. To elucidate early responses of PGPR to root exudates, we investigated changes in the transcriptome of a Gram-positive PGPR to plant root exudates.ResultsBacillus amyloliquefaciens FZB42 is a well-studied Gram-positive PGPR. To obtain a comprehensive overview of FZB42 gene expression in response to maize root exudates, microarray experiments were performed. A total of 302 genes representing 8.2% of the FZB42 transcriptome showed significantly altered expression levels in the presence of root exudates. The majority of the genes (261) was up-regulated after incubation of FZB42 with root exudates, whereas only 41 genes were down-regulated. Several groups of the genes which were strongly induced by the root exudates are involved in metabolic pathways relating to nutrient utilization, bacterial chemotaxis and motility, and non-ribosomal synthesis of antimicrobial peptides and polyketides.ConclusionsHere we present a transcriptome analysis of the root-colonizing bacterium Bacillus amyloliquefaciens FZB42 in response to maize root exudates. The 302 genes identified as being differentially transcribed are proposed to be involved in interactions of Gram-positive bacteria with plants.

  12. Joseph Ratzinger's theological hermeneutics for Christians' faith ...

    African Journals Online (AJOL)

    While the central effort of the paper is to evaluate the adequacy or otherwise of Ratzinger‟s model for Christians‟ faith enhancement, the guiding question shall be what possibility such method has in ameliorating the “danger of clutching the air” and in establishing an “intimate friendship with Jesus” through the gospels.

  13. St Joseph's Community Hospital, Stranorlar, Donegal.

    LENUS (Irish Health Repository)

    Harrison, Peter

    2017-06-01

    The experimental gingivitis study of Löe et al.1 demonstrated a cause and effect relationship between plaque accumulation and gingival inflammation, and helped to establish plaque\\/biofilm as the primary risk factor for gingivitis. When healthy individuals withdrew oral hygiene efforts, gingival inflammation ensued within 21 days in all subjects. Once effective plaque removal was recommenced, clinical gingival health was quickly re-established – indicating that plaque-associated inflammation is modifiable by plaque control. As current consensus confirms that gingivitis and periodontitis may be viewed as a continuum of disease,2 the rationale for achieving effective plaque control is clear.

  14. 1116-IJBCS-Article-Joseph Djeugap Fovo

    African Journals Online (AJOL)

    hp

    ulaval.ca; Fax : (237) 33 45. 15 66, BP 222 ..... Berger RD. 1980. Measuring disease intensity. In. Proc. EC. Stakman. Commemorative Symposium on Crop. Loss Assessments, St. Paul (ed). University of Minesota Misc : Minesota. Campbell CL ...

  15. 2036-IJBCS-Article-Joseph Djeugap Fovo

    African Journals Online (AJOL)

    hp

    Amorim L, Berger RD, Hau B. 1997. Angular leaf spot of beans: relationships between disease, healthy leaf area and yield. Phytopathology, 87: 506-515. Buruchara R, Mukankusi C, Kwasi A. 2010. Bean disease and pest identification and management. Handbooks for small-scale seed producers N° 04: Kampala, Uganda;.

  16. 935-IJBCS-Article-Joseph Magadula

    African Journals Online (AJOL)

    DR GATSING

    In vitro antimicrobial activities against cariogenic streptococci and their antioxidant capacities: A comparative study of green tea versus different herbs. Food Chem., 110: 859-864. Wang SY, Lin HS. 2000. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental ...

  17. Proval planirovanija infljatsii / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2008-01-01

    Tuntumad maailma pankurid moodustavad üksmeelse klubi, mis juhindub kindlatest joontest. 80. aastate alguses sattusid nad Milton Friedmani monetarismiteooria mõju alla. Uueks vooluks on kujunenud inflatsiooni planeerimine, mis tähendab, et iga kord, kui hinnatõus ületab teatud taseme, tuleb tõsta intressimäärasid

  18. Bushi eelarve must auk / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2003-01-01

    George Bushi administratsiooni poolt läbi viidud maksukärped on tekitanud USA eelarvesse 450 miljardi dollari suuruse puudujäägi, samuti kasvab USA kaubavahetusbilansi defitsiit, mis võib olla maailmamajanduse ebastabiilsuse peamiseks põhjuseks.

  19. 1197-IJBCS-Article-Joseph Edoga

    African Journals Online (AJOL)

    hp

    Morphometric studies of thyroid gland of Wistar rats exposed to alcohol during pregnancy and/or lactation. Josephat Edoga ONU 1*, Bankole Olusiji OKE 2, Peter Chuka OZEGBE 2 and. Johnson Oluwayemisi OYEWALE 3. 1Department of Veterinary Anatomy, Usmanu Danfodiyo University, Sokoto, Nigeria. 2Department of ...

  20. 1298-IJBCS-Article-Joseph Djedjoho

    African Journals Online (AJOL)

    KODJIO NORBERT

    AMB),. Bacillus spp. and. Staphylococcus spp. changes during the fermentation process with or without additives. Aerobic mesophilic bacteria count significantly increased as .... dormant endospore into a Bacillus vegetative cell usually involves ...

  1. 1398-IJBCS-Article-Joseph Kouassi+

    African Journals Online (AJOL)

    hp

    3Université d'Abobo-Adjamé, Laboratoire de Chimie Bio-Organique et de Substances Naturelles,. 02 BP 801 Abidjan 02, Côte d'Ivoire. 4INRA Science du Sol, BP 20619, 45166 Olivet cedex, ...... Mobilité relative des métaux lourds issus de la décharge d'Akouédo et risque de contamination de la nappe du Continental.

  2. 1082-IJBCS-Article-Joseph Dioha

    African Journals Online (AJOL)

    DR GATSING

    The Journal of the American. Medical Association, 281(15): 1640. Izuagie AA, Izuagie FO. 2007. Iodometric determination of ascorbic acid (vitamin. C) in citrus fruits. Research Journal of. Agricultural and Biological Sciences,. 3(5): 367 – 369. Klein BP, Perry AK. 1982. Ascorbic-acid and vitamin-activity in selected vegetables.

  3. Inflammation, suppuration, putrefaction, fermentation: Joseph Lister's microbiology

    Science.gov (United States)

    Richardson, Ruth

    2013-01-01

    This paper focuses on Lister's inaugural lecture at King's College, London, in October 1877. As the new Professor of Clinical Surgery, Lister had much to report, including impressively high survival rates from complex operations previously regarded as foolhardy. Instead, he chose to address the processes of fermentation in wine, blood and milk. His reasons are not obvious to a modern audience, just as they probably were not to those who heard him in the Great Hall at King's. Having brought microbiological apparatus from his laboratory to the lecture theatre and presented proof of bacterial variety and specificity, Lister publicly demonstrated the creation of the first pure bacterial culture in the history of microbiology. It was an ingenious and well-thought-out strategy designed to generate a frame of mind among his new colleagues and future students, receptive to the causative role of bacteria in septic diseases. His timing was impeccable.

  4. Alexander Ogston, micrococci, and Joseph Lister.

    Science.gov (United States)

    Lyell, A

    1989-02-01

    This paper recalls the notable achievement, in 1880, of Alexander Ogston, a surgeon who, seeking the cause of suppuration, showed that acute abscesses result from micrococci. There were two kinds. One, arranged in chains, had been called streptococci already; the other, in clumps, he named staphylococci. He injected micrococci into animals. If blood poisoning occurred in them, it followed localized tissue infection. This information, applied to surgical events, suggested that the "hospital diseases" were a sequel to wound suppuration and explained why antiseptic surgery controlled both conditions. Ogston's observations are now common knowledge, but Lister rejected them. It is suggested he did so because he relied on intuition rather than experiment. The scene is set for Lister and Ogston's discoveries by a review of the historical background. Patients subjected to surgery faced a terrible ordeal and a very real chance of death from the mysterious hospital diseases. Surgeons viewed the mortality with bland detachment, blaming fate. But Simpson and Semmelweis were deeply concerned. However, puerperal fever was regarded as entirely distinct from the hospital diseases, and neither condition connected in any way with suppuration in wounds. Simpson, Semmelweis, Lister, and Ogston all found their ideas scorned by members of the profession, which may have feared being held responsible for deaths. Ogston's achievement lives on, but he has been forgotten. We should remember him.

  5. Paediatric Malignancies | Joseph | African Journal of Paediatric ...

    African Journals Online (AJOL)

    Other common malignancies included sarcomas 10(14.71%), neurofibromatosis 9(13.24%), nephroblastoma 8(11.77%), acute lymphoblastic leukaemia 5(7.35%) and retinoblastoma 4(5.88%). The less common paediatric malignancies were melanoma, invasive lobular breast carcinoma and squamous cell carcinoma of ...

  6. 649-IJBCS-Article-Kutshik Joseph R

    African Journals Online (AJOL)

    DR GATSING

    , 1982). Some of the mutagenic tools are Site-directed mutagenesis, direct selection, environmental stress, transposons, physical tools such as. Ultraviolet light and chemical agents. (Williams and Michael, 2000). Mutation provides the basis of ...

  7. St. Joseph's Hospital, Lifford Road, Ennis, Clare.

    LENUS (Irish Health Repository)

    Hogan, A E

    2011-11-01

    The innate immune cells, invariant natural killer T cells (iNKT cells), are implicated in the pathogenesis of psoriasis, an inflammatory condition associated with obesity and other metabolic diseases, such as diabetes and dyslipidaemia. We observed an improvement in psoriasis severity in a patient within days of starting treatment with an incretin-mimetic, glucagon-like peptide-1 (GLP-1) receptor agonist. This was independent of change in glycaemic control. We proposed that this unexpected clinical outcome resulted from a direct effect of GLP-1 on iNKT cells.

  8. 649-IJBCS-Article-Kutshik Joseph R

    African Journals Online (AJOL)

    DR GATSING

    The beauty of modern biotechnology lies in its specificity: one can target the production of an ... characteristics using standard methods (refs) stock cultures were maintained at 4 ˚C on. MRS medium for further use. ... simple standard deviation, percentage,. ANOVA and correlation at 95% level of significance. RESULTS.

  9. Single sperm analysis of the CAG repeats in the gene for Machado-Joseph disease (MJD1): evidence for non-Mendelian transmission of the MJD1 gene and for the effect of the intragenic CGG/GGG polymorphism on the intergenerational instability.

    Science.gov (United States)

    Takiyama, Y; Sakoe, K; Soutome, M; Namekawa, M; Ogawa, T; Nakano, I; Igarashi, S; Oyake, M; Tanaka, H; Tsuji, S; Nishizawa, M

    1997-07-01

    To investigate the mechanism of the meiotic instability of expanded CAG repeats in the gene for Machado-Joseph disease (MJD1), we analyzed the CAG repeat sizes of 1036 single sperm from six individuals with Machado-Joseph disease (MJD). The segregation ratio between single sperm with an expanded allele and those with a normal allele is significantly different (P GGG] genotype, significantly greater instability of the CAG repeat was observed compared with single sperm from individuals with the [expanded (CAG)n-CGG]/[normal (CAG)n-CGG] genotype (F-test, P GGG polymorphism on the intergenerational instability of the CAG repeats in the MJD1 gene, which have been observed in clinical and genetic studies. Our results indicate similarities and dissimilarities between MJD and Huntington's disease or myotonic dystrophy in terms of the inter-allelic interaction, segregation distortions and size distribution of trinucleotide repeats in mutant alleles. Further study is required to determine whether there is a common mechanism underlying the instability of the triplet repeats in 'triplet repeat diseases'.

  10. Nódulo umbilical metastático (nódulo da Irmã Maria José: um sinal de alerta para tumoração maligna intra-abdominal - relato de caso Sister Mary Joseph's nodule: a warning sign for intra-abdominal malignant tumors. A case report

    Directory of Open Access Journals (Sweden)

    Homero Soares Fogaça

    2003-07-01

    Full Text Available O nódulo da "Irmã Maria José" é tumor metastático que acomete a cicatriz umbilical e pode ser a primeira evidência de neoplasia intra-abdominal disseminada. Os autores relatam o caso de uma paciente com o nódulo da "Irmã Maria José" no qual o diagnóstico do tumor primário só foi possível por meio dos testes imuno-histoquímicos da lesão biopsiada da pele.The umbilical metastatic tumoral nodule, Sister Mary Joseph's nodule, is a rare clinical sign indicative of disseminated intra-abdominal tumor, and may be the first evidence of malignancy. The authors report a case of a patient with umbilical metastatic nodule in whom the diagnosis of the primary tumor was possible by immunohistochemistry of the lesion biopsy.

  11. 29 CFR 4.117 - Work subject to requirements of Walsh-Healey Act.

    Science.gov (United States)

    2010-07-01

    ... automobile, truck, or other vehicle, construction equipment, tractor, crane, aerospace, air conditioning and..., calculators, and other electronic equipment; (iv) Inspecting, testing, calibration, painting, packaging...

  12. Red River of the North Walsh and Pembina Countries, North Dakota Farmstead Ring Levees.

    Science.gov (United States)

    1983-12-01

    resource needs in the metro - politan area. Farmstead ring N/A Assesses the potential Ongoing. levee analysis for Federal involve- ment in developing...sites. C-2-4 AW31ID11 C 7TCICAL XFOUKATIOU CTIOE 3 gEooEics SCT =u 3 TABM OF CWKT Item Paso INTRODUCTION C-3-1 ECONOMIC CHARACTERISTICS C-3-2 Population

  13. Rodolfo Walsh's anti-mythical writings. A history about identity tearing. Argentina 1955-1977

    Directory of Open Access Journals (Sweden)

    Nathaly Rodríguez Sánchez

    2015-01-01

    Full Text Available The article uses Rodolfo Walsh’s literary and journalistic work as a source to write a history about the rupture of nationalist feeling in Argentina between 1955 and 1977. It reviews the author’s literary production like one that is linked with three issues of Argentina’s history. First with the transformation of social context in that period because of ideological confrontation, second with the political fragmentation of the social bases, and last, with the establishment and radicalization of government repression. It proposes the category of tearing-of-identity like a useful tool to make a history about the feeling of subjective identity’s tearing with regarding the national identity. A situation that happens before open war declaration, and brings into play Nation-State stability.

  14. Veterinary education for global animal and public health, D.A. Walsh : book review

    Directory of Open Access Journals (Sweden)

    C.M.E. McCrindle

    2010-05-01

    Full Text Available This 28th annual volume published by the World Organisation for Animal Health (OIE, addresses the need for a global shift in the way veterinary students are taught veterinary public health (VPH. As well as taking the lead in prevention and control of animal diseases, the OIE develops health and welfare standards to promote food security and equitable international trade in animals and animal products.

  15. “El libro que contiene onze partidos del M. Dn Joseph de Torres”. ¿Torres y Martínez Bravo, o Torres y Vergara? Aproximaciones a una interpretación filológica del manuscrito de la colección Sánchez Garza

    Directory of Open Access Journals (Sweden)

    Delgado Parra, Gustavo

    2008-12-01

    Full Text Available The Torres Book from the Sanchez Garza collection is one of the most polemic issues in the study of Hispanic music. This controversy has been the result of two main factors. On the one hand, the authorship problems and on the other, the apparent disorder of the musical content in this manuscript due to the ineffi cient work done by the copiers who gave it form. The latter has lead to conclude, as a generalized opinion, that it is a highly corrupted copy of the organ works that could have been composed by the famous Spanish composer, organist, musical theorist and printer, Joseph de Torres y Martinez Bravo (*1670c; †1738; in which case the copier would be the one to blame for the demerit of such a renowned musician of the Royal Chapel of Madrid. If to this we add the transcription offered by the CENIDIM in 1993 which multiplies the confusion, we are facing pieces of music full of questions and a musical text which is neither effective nor convincing.El Libro de Torres de la colección Sánchez Garza, es uno de los documentos más polémicos de los últimos tiempos en la musicología hispánica. Esta polémica ha sido el resultado de dos factores fundamentales: por un lado el problema de la autoría, y por el otro, el aparente desorden del contenido musical del manuscrito, debido supuestamente, al trabajo inefi ciente de los copistas que le dieron forma. Esto último ha llevado a concluir, como opinión generalizada, que se trata de una copia corrompida de las obras para órgano que habrían sido compuestas por el prestigiado compositor, organista, teórico musical e impresor español, Joseph de Torres y Martínez Bravo (*1670c; †1738, en cuyo caso el copista del manuscrito sería el responsable de dicho desorden; lo que ha llevado a suponer, a otros investigadores, que incluso las obras en cuestión no sean de su autoría. A esto debemos agregar la confusa y a veces errónea transcripción ofrecida por el CENIDIM en 1993, en cuyo caso las

  16. ”Art and psychoanalysis – 15 June 1988. Speakers: Professor Joseph Sandler and Professor Sir Ernst Gombrich”, part of the series “Dialogues on Contemporary Issues” hosted by the British Psycho-Analytical Society in the summer term of 1988

    Directory of Open Access Journals (Sweden)

    Rachel Dedman (ed.

    2012-12-01

    Full Text Available The previously unpublished conversation between Ernst Gombrich and Joseph Sandler in 1988 constitutes an exciting meeting of minds in the field of art history and psychoanalysis, respectively. The two discuss ‘the artist’ as a term; the impulse inherent in the creation of art; taste; and the affective power of art, particularly in the light of the work of Freud and their shared friend, Ernst Kris. Gombrich seems both comfortable with the psychoanalytic theory they discuss, and also keen to steer the discussion in certain directions – quoting from Cicero, Van Gogh and I.E. Richards. At the point at which questions are opened up to the audience, the most interesting thing of note is the revelation that Gombrich was a member of ‘The Image Group’, which research has revealed was more accurately known as ‘The Imago Group,’ a society of psychoanalysts and dedicated analysands, of which Gombrich’s membership is unusual. As Gombrich is often considered reticent about psychoanalysis, this dialogue constitutes evidence that late in life he continued to engage in discussion about its application and interpretation in an artistic context.

  17. State, Governance and Insecurity in Africa | Joseph | Democracy ...

    African Journals Online (AJOL)

    Democracy & Development: Journal of West African Affairs. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 3, No 2 (2003) >. Log in or Register to get access to full text downloads.

  18. St. Joseph's Centre, Crinken Lane, Shankill, Co. Dublin.

    LENUS (Irish Health Repository)

    Sermeus, Walter

    2011-04-18

    Abstract Background Current human resources planning models in nursing are unreliable and ineffective as they consider volumes, but ignore effects on quality in patient care. The project RN4CAST aims innovative forecasting methods by addressing not only volumes, but quality of nursing staff as well as quality of patient care. Methods\\/Design A multi-country, multilevel cross-sectional design is used to obtain important unmeasured factors in forecasting models including how features of hospital work environments impact on nurse recruitment, retention and patient outcomes. In each of the 12 participating European countries, at least 30 general acute hospitals were sampled. Data are gathered via four data sources (nurse, patient and organizational surveys and via routinely collected hospital discharge data). All staff nurses of a random selection of medical and surgical units (at least 2 per hospital) were surveyed. The nurse survey has the purpose to measure the experiences of nurses on their job (e.g. job satisfaction, burnout) as well as to allow the creation of aggregated hospital level measures of staffing and working conditions. The patient survey is organized in a sub-sample of countries and hospitals using a one-day census approach to measure the patient experiences with medical and nursing care. In addition to conducting a patient survey, hospital discharge abstract datasets will be used to calculate additional patient outcomes like in-hospital mortality and failure-to-rescue. Via the organizational survey, information about the organizational profile (e.g. bed size, types of technology available, teaching status) is collected to control the analyses for institutional differences. This information will be linked via common identifiers and the relationships between different aspects of the nursing work environment and patient and nurse outcomes will be studied by using multilevel regression type analyses. These results will be used to simulate the impact of changing different aspects of the nursing work environment on quality of care and satisfaction of the nursing workforce. Discussion RN4CAST is one of the largest nurse workforce studies ever conducted in Europe, will add to accuracy of forecasting models and generate new approaches to more effective management of nursing resources in Europe.

  19. Joseph Kamaru's Music:Cutting with "Words, Not Swords" | wa ...

    African Journals Online (AJOL)

    The argument is that music is not always a site of subversion, but that the moment of production of a certain piece plays a crucial role. Kamaru's character vacillates between two extremes – as a praise singer and as a critic to the same regime in a period of six years. However, I argue that everyday living is always about ...

  20. Machado-Joseph disease presenting as severe asymmetric proximal neuropathy

    NARCIS (Netherlands)

    van Schaik, I. N.; Jöbsis, G. J.; Vermeulen, M.; Keizers, H.; Bolhuis, P. A.; de Visser, M.

    1997-01-01

    Despite much effort, a 74 year old man with progressive proximal weakness and sensory disturbances due to axonal neuropathy remained a diagnostic problem. Investigation of his family disclosed an additional patient with a cerebellar syndrome and a family member with mainly pyramidal features.

  1. Joseph L Doob and Development of Probability Theory

    Indian Academy of Sciences (India)

    IAS Admin

    He started his PhD work in the same department right away in 1930. One W Seidel was a young faculty member at Harvard. Doob and Seidel worked on the behavior of analytic function near the boundary points of the unit disc D = {z C:|z|: 1}. He pursued it further and got some interesting results. He wrote these up as ...

  2. St. Joseph's Unit, Bantry General Hospital, Bantry, Cork.

    LENUS (Irish Health Repository)

    2011-08-30

    Abstract Lactobacillus plantarum LMG P-26358 isolated from a soft French artisanal cheese produces a potent class IIa bacteriocin with 100% homology to plantaricin 423 and bacteriocidal activity against Listeria innocua and Listeria monocytogenes. The bacteriocin was found to be highly stable at temperatures as high as 100°C and pH ranges from 1-10. While this relatively narrow spectrum bacteriocin also exhibited antimicrobial activity against species of enterococci, it did not inhibit dairy starters including lactococci and lactobacilli when tested by well diffusion assay (WDA). In order to test the suitability of Lb. plantarum LMG P-26358 as an anti-listerial adjunct with nisin-producing lactococci, laboratory-scale cheeses were manufactured. Results indicated that combining Lb. plantarum LMG P-26358 (at 108 colony forming units (cfu)\\/ml) with a nisin producer is an effective strategy to eliminate the biological indicator strain, L. innocua. Moreover, industrial-scale cheeses also demonstrated that Lb. plantarum LMG P-26358 was much more effective than the nisin producer alone for protection against the indicator. MALDI-TOF mass spectrometry confirmed the presence of plantaricin 423 and nisin in the appropriate cheeses over an 18 week ripening period. A spray-dried fermentate of Lb. plantarum LMG P-26358 also demonstrated potent anti-listerial activity in vitro using L. innocua. Overall, the results suggest that Lb. plantarum LMG P-26358 is a suitable adjunct for use with nisin-producing cultures to improve the safety and quality of dairy products.

  3. De dialectisch-materialistische filosofie van Joseph Dietzgen

    OpenAIRE

    Schaaf, Jasper Willem

    1993-01-01

    Dietzgen's philosophy is monistic in nature. This study is focused on the question in what way Dietzgen treats the relation between unity and diversity as an epistemological and ontological issue. How does Dietzgen formulate the unity of all that exists, and what is the place and the role of the process of gaining knowledge in this formulation? These questions serve as stepping stones to the central question: What is the position of Dieagen's thinking with regard to the philosophy of Feuerbac...

  4. "Transracial Adoption and Foster Care," by Joseph Crumble. Book Review.

    Science.gov (United States)

    Kennedy-Williams, Delores

    2001-01-01

    Notes that Crumble's book assists professionals in preparing families who adopt transracially and highlights the importance of understanding one's racial and cultural identity. Describes three areas of focus: complex issues involved in raising cultural issues, providing services to families, and staff attitudes and views. Highly recommends the…

  5. Rost obespetshat levõje / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2008-01-01

    Nii parem- kui ka vasakpoolsed poliitikud on huvitatud majanduskasvust, kuid strateegiates on tuntavad erinevused. Majanduskasv peab olema stabiilne, kuid kasv keskkonna, tarbimisbuumi, laenude või haruldaste maavarade kasutuselevõtu arvelt seda ei taga

  6. Research Design for the Chief Joseph Dam Cultural Resources Project.

    Science.gov (United States)

    1984-01-01

    questions regarding ethnographic reconstruction of Plateau culture: (1) what was the nature of * the early acculturation process on various Plateau groups...will be Incorporated into the summary report (Jaehnig and Campbell 1984d). In general, the project area region produces a varied supply of roots, berries ...collecting edible plants and other materials. The bases of rockfalls and talus slopes support a variety of shrubs valued for their berries . Serviceberries

  7. Öelge Bushile lihtsalt ei / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2003-01-01

    Autor leiab, et poliitiliselt turvalisema ja majanduslikult stabiilsema maailma eelduseks on poliitilise globaliseerumise järele jõudmine majanduslikule. Demokraatia ja sotsiaalse õigluse põhimõtteid tuleks laiendada üle riigipiiride.

  8. Vaja on uusi makse Venemaa oligarhidele / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2004-01-01

    Autor analüüsib president Jeltsini võimuloleku ajal tehtud vigu, mis soodustasid oligarhia tekkimist ning leiab, et erinevate maksude kehtestamine leevendaks oligarhide suurest osatähtsusest tulenevat ohtu riigi demokraatiale

  9. St. Joseph's Nursing Home, Lurgan Glebe, Virginia, Cavan.

    LENUS (Irish Health Repository)

    Ripke, Stephan

    2011-10-01

    We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10(-11)) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)).

  10. Looking for a more useful Atherogenic Index for Nigerians | Josephs ...

    African Journals Online (AJOL)

    ... and none of them had abnormal lipid ratio. Sixty percent of hypertensives had positive AIP. Normotensives had only negative AIP values. The AIP therefore holds promise as a better index of atherogenicity than the cholesterol ratios or absolute lipid status. Keywords: Atherogenic index; esterification rate; Nigerian African ...

  11. 1428-IJBCS-Articles-Joseph D.H.

    African Journals Online (AJOL)

    hp

    10. This situation could be explained by the transfer of nutrients from leaves to the reproductive organs during flowering and fruiting (Hewitt and Marruh, 1986). In the case of S. radiatum and J. tenella, flowering beginning was observed at 7 WAT and 14. WAT respectively while it was observed at 8. WAT for C. sesamoïdes.

  12. Summary of Results, Chief Joseph Dam Cultural Resources Project, Washington.

    Science.gov (United States)

    1985-01-01

    Stenholm counted over 400 false onion (r!diasa dugJJl , 40 wild carrot (Lo malum macrocarpum), and 240 chocolate tips (Lomatlun dissectum) In a community...ree;n Sk it dr*sting srip bark ’II. trc.114 rloe is ane , *Soak Skin (l). Str -a or M-Ma,. 7 sonet of fotify Rocks to hold ski. flat (I). eke la. -idays...cattle have found space to graze the slopes. In sandy areas a fragile community exists on south-facing slopes composed ot spring sunflower, chocolate

  13. The alleged poisoning of Joseph Stalin: proof beyond reasonable doubt?

    Science.gov (United States)

    Quigley, James; Keating, Áine

    2013-12-01

    The name "Ioseb Besarionis dze Dzhugashvili" is as unassuming as it is unknown. It is the birth name of the brutal dictator who changed the face of Europe and whose actions still influence our lives today. Stalin, the man responsible for the slaughter of over twenty million of his own Soviet citizens and yet, the man who transformed the USSR from the feudalistic society of the Tsar's to a twentieth century military powerhouse that was instrumental in the defeat of Nazi Germany. Known as "Koba" to his friends, he cultivated a cult of personality where he was, and to a certain extent still is, admired in Russia and the former Soviet states. This paper will look at the following questions: why when he fell gravely ill did his comrades wait so long before seeking medical assistance? why were there omissions in the final post mortem report?, and why did one his closest lieutenants boast so openly about having murdered him.

  14. A King over Egypt, Which Knew Not Joseph.

    Science.gov (United States)

    Coffman, William E.

    1993-01-01

    Although it is true that today's education needs improvement, schools today are not all bad. The opinions of the following five experts, whose views are worth hearing are introduced: (1) Thomas Hopkins; (2) Ralph Tyler; (3) E. F. Lindquist; (4) Walter Cook; and (5) Harold Benjamin. (SLD)

  15. Joseph L Doob and Development of Probability Theory

    Indian Academy of Sciences (India)

    IAS Admin

    Doob says, “I knew nothing about college education or colleges when I finished my high school education in 1926”. On the advice of his high school principal, Doob applied to Harvard. He says in the interview with Snell [1] that he ... after World War II (roughly from 1945–1970). Honours and Recognition. Here are some of ...

  16. Chief Joseph Dam, Columbia River, Washington, Community Impact Reports,

    Science.gov (United States)

    1980-05-01

    4-13 -,v for accidents involving propurty damage, personal injury and death will be increased during the construction period. Traffic law enforcement...I or more dIays; n t he Cerl o%’,7ent. The i mpac7*, on lCa LMMI n~rP’en quiant if ied from ava-J1able d’ata. linempl o)\\rnt qathenrod byv the state

  17. Empowering the Nigerian Child through Drama *Joseph Agofure ...

    African Journals Online (AJOL)

    University Oye Ekiti in the 2014/2015 academic session; which this researcher was the course coordinator. ... photographs, video recording of drama activities, performance interrogation and interviews,” (202). ... If learning styles are matched with appropriate teaching approaches, then student motivation, performance and.

  18. Influencia de Mircea Eliade en Joseph Mitsuo Kitagawa

    OpenAIRE

    Ordóñez Arnau, Juan Enrique

    2007-01-01

    Se defiende la tesis de que Kitagawa es un autor plenamente eliadiano, uno de los primeros eliadianos. ¿En qué consiste, pues, la grandeza de Kitagawa, si en nada sustancial difiere de las posiciones de Eliade? Primero, en ser uno de los grandes difusores y defensores de la historia de las religiones, la Religionswissenschaft, tal y como la comprenden Wach y Eliade, como una disciplina independiente y articulada, con una metodología y un área de trabajo definidos. Y segundo, porque habiéndose...

  19. Joseph Schumpeter and his legacy in innovation studies

    NARCIS (Netherlands)

    Hospers, Gerrit J.

    2005-01-01

    Inspired by the recent rediscovery of work of Schumpeter in science and policymaking the author reviews and appraises Schumpeterian theory and that of his followers in innovation studies. Although Schumpeter’s vision suffers from some defects, I argue that there is more to learn from this author

  20. Comment on 'the case of Melanie' by Joseph Cambray.

    Science.gov (United States)

    Gastelumendi, Eduardo

    2011-06-01

    The discussion comments firstly on the role of synchronicity which seems so natural and significant for Jungians but which Freudians would think no more than interesting coincidences. This gives an idea of how different the two schools' approach to the psyche can be. Some theoretical elaboration is made regarding archetypes and primal phantasies: primal phantasies are much related to sexuality, but sexuality understood as intimately linked to the great mysteries of life. The discussion of the clinical work shows more similarities than differences. This suggests that for both perspectives the clinical is sovereign. As we know, respect and care for the patient's evolution, true concern for the patient and skilful use of technique remain the most important indicators of successful therapeutic work in the different psychotherapeutic approaches. © 2011, The Society of Analytical Psychology.

  1. Les limites du capitalisme selon Joseph Schumpeter et Karl Marx The limits of capitalism by Joseph Schumpeter and Karl Marx

    Directory of Open Access Journals (Sweden)

    Omer Moussaly

    2012-11-01

    Full Text Available À jongler avec les mérites et les ratés de la théorie de Marx et de ses adeptes, Schumpeter semble vouloir s’imposer en tant qu’arbitre unique et impartial du marxisme. Bien qu’il reconnaisse plusieurs mérites à la conception économique de Marx, Schumpeter soulève de multiples limites à l’analyse des marxistes orthodoxes qui ne font que corroborer sa prise de position critique du marxisme. Une lecture des critiques et des réponses que Schumpeter a adressées au marxisme permet de révéler les points communs et les divergences entre les deux auteurs. Chez Schumpeter comme chez Marx, le capitalisme est un mode passager de la production sociale. Schumpeter se fixe comme objectif de combler la lacune des marxistes qui n’ont pas su identifier les vraies raisons du dépérissement du capitalisme. Il lui fallait relever le défi de critiquer certains adeptes de Marx sans pour autant s’en prendre trop au fondateur du marxisme auquel il vouait une admiration sincère.Juggling with the merits and flaws of Marx and his followers, Schumpeter seems to be acting as an impartial judge, especially since he eliminates the extreme arguments of both the Marxists and their opponents. His technique seeks to make his position unassailable from either side of the debate. Although he recognizes several merits to the economic conceptions of Marx, Schumpeter points out several limits of orthodox Marxists which only confirm his critical position towards Marxism. A careful reading of Schumpeter’s commentary on Marxism reveals many points in common between himself and Marx. For Schumpeter as for Marx, capitalism is a transitory and historically limited social mode of production. Unlike most Marxists, who merely repeated ideological slogans from the works of Marx, Schumpeter believed he had discovered the true reasons behind capitalism’s demise. With his critique of Marxism, Schumpeter did not wish to diminish the merit of its founder, but rather to save what he thought was valuable in the doctrine of Marx.

  2. Archeological and Historic Cultural Resources Inventory for a Proposed Flood Control Project at Grafton, Walsh County, North Dakota.

    Science.gov (United States)

    1983-10-01

    2- I e , • el I.CONTOUR INTERVAL r Ep I - 0/ CH~k4N~ STRU:CT~URE.. - I. -& -W,/ 0-- and , F C " 2 I- of base map: U.S.G.S. Grafton, North Dakota...rubble of cobble-size concrete chinks to a depth of about 25.0 cm (9.8 in.). These concreto chunk- we’e mixed with an organic eolian silt. The very...Arvilla Complex. Minnesota Prehistoric Archaeology Series, 9. Joyes, Dennis. 1970. The Culture Sequence at the Avery Site at Rock Lake. In: Hlady, W. ( eL

  3. Archeological and Historic Cultural Resources Inventory for a Proposed Flood Control Project at Grafton, Walsh County, North Dakota.

    Science.gov (United States)

    1983-10-01

    10,000 B.C. to 6000 B.C.) subsistence was based primarily on exploitation of herds of big game animals, popularly referred to as megafauna . Much of this... megafauna consisted of presently extinct forms of bisoa, as well as mammoths and animals which now are extinct in North America (e.g., various... megafauna was a communal effort, involving large numbers of people. Most Paleo-Indian sites recorded to date have been large kill sites; however, a few

  4. Archaeological and Historical Resources Investigations for the Red River of the North Ring Levee Project, Pembina and Walsh Counties, North Dakota, (Phase 1),

    Science.gov (United States)

    1984-04-01

    tridentata Three- toothed cinquef oil Rubus pubescens Creeping Blackberry Prunus pensylvaInica Bird cherryI Anorpha navna Fragrant false indigo Rhannus...consist of fabric-impressed, bossed, or punctated conoidal -shaped pottery vessels. Campsites appear to be small, temporary camps of nomadichunters and

  5. Le nodule de Soeur Marie Joseph, une rare métastase contributive ...

    African Journals Online (AJOL)

    Nous rapportons l'observation d'une patiente de 80 ans admise pour une masse abdominopelvienne compliquée d'une ascite de grande abondance d'origine ... Nous attirons l'attention des cliniciens: oncologue et chirurgiens à cette entité clinique, qui est rare certes, mais très contributive au diagnostic étiologique et par ...

  6. Evaluation of Wildlife Mitigation Sites at the Chief Joseph Dam Project (1993/1994 Season)

    Science.gov (United States)

    1994-07-22

    golden currant GROSSULARIACEAE Iff Sites RICE Ribes cereum squaw currant GROSSULARIACEAE BS, BB ROPS Robinia pseudbacacia black locust LEGUMINOSAE ...sifkt lupine LEGUMINOSAE Irr.L SiB S, BE MAEX .Madla exlgua little tarweed EOPSA S, BE MESA Yedlcaso soelva aW& EGMliSA Irr. Site MEAL Mfelilowu alba

  7. Joseph et al., Afr J Tradit Complement Altern Med. (2013) 10(5):299 ...

    African Journals Online (AJOL)

    AJTCAM

    constituent in tobacco smoke, cured and fried meals, cheddar cheese, agricultural chemicals, cosmetics, pharmaceutical products, etc. Materials and Methods. Preparation of Semecarpus anacardium nut milk extract. Nut milk extract was made as per standard technique described in system of Ayurvedic medicine by boiling ...

  8. A designated centre for people with disabilities operated by St Joseph's Foundation, Limerick

    LENUS (Irish Health Repository)

    2012-02-01

    BACKGROUND: We assess our long-term experience with regards the safety and efficacy of Mycophenolate Mofetil (MMF) in our low risk renal transplant population and compared it retrospectively to Azathioprine (AZA) immunosuppressive regimen. Patients and methods. Between January 1999 and December 2005, 240 renal transplants received MMF as part of their immunosuppressive protocol (MMF group). AZA group of 135 renal transplants was included for comparative analysis (AZA group). Patients received Cyclosporine was excluded from this study. RESULTS: The incidence of biopsy proven 3-month acute rejections was 30 (12.5%) in MMF group and 22 (16%) in AZA group respectively (P = 0.307). Patient survival rates at 1 and 5 years for the MMF group were 97 and 94%, respectively, compared to 100% and 91% at 1 and 5 years respectively for the AZA group (P = 0.61). Graft survival rates at 1 and 5 years for the MMF group were 95 and 83%, respectively, compared to 97 and 84% at 1 and 5 years, respectively for the AZA group (P = 0.62). CONCLUSION: There was no difference in acute rejection episodes between MMF and AZA based immunotherapy. Additionally, we observed no significant difference concerning graft survival in the MMF group when compared to AZA group.

  9. Ontología e historia en el pensamiento de Joseph Ratzinger

    Directory of Open Access Journals (Sweden)

    Rodrigo Polanco F

    2011-01-01

    Full Text Available El texto estudia la relación entre historia y ontología, a partir del pensamiento eclesiológico de J. Ratzinger. El acontecimiento pascual-pneumatológico ha hecho presente lo escatológico en la historia, es una escatología, en un cierto sentido, ya realizada y, por lo tanto, históricamente verificable. Escatología significa, en este caso, «Dios con nosotros», esto es, «recapitulación de todas las cosas en Cristo» (Ef 1, 10, koinonía sacramental en la Iglesia. La centralidad pneumatológica y escatológica de Cristo se perpetúa eclesialmente al concebir a la Iglesia como sacramento de unidad. Es Cristo perpetuado sacramentalmente en la Iglesia. Ella es pueblo y casa de Dios, lugar en donde los hombres participan del servicio de Cristo a la humanidad, porque allí -de manera cultual y existencial, en la liturgia y en la caritas- aprenden a ser una ofrenda permanente conforme al Logos, al ser «uno en Cristo Jesús» (Gál 3, 28.The text explores the relationship between history and ontology based on the ecclesiological thought of J. Ratzinger. The pneumatological Easter event has made eschatology present in history; this is an eschatology that in a certain sense is already realized, and therefore, historically verifiable. Eschatology means, in this case, "God with us," that is, "recapitulation of all things in Christ" (Eph 1.10, sacramental koinonia in the Church. The pneumatological centrality and eschatology of Christ is perpetuated ecclesiastically by conceiving the Church as the sacrament of unity. Christ is sacramentally perpetuated in the Church. The Church is the people and house of God, the place where men participate in Christ's service to humanity, because there, in a cultual and existential way, in the liturgy and in the caritas, they learn to be a permanent offering in accordance with Logos, to be "one in Jesus Christ" (Gal 3.28.

  10. The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.

    Science.gov (United States)

    Kuhlbrodt, Kirsten; Janiesch, Philipp Christoph; Kevei, Éva; Segref, Alexandra; Barikbin, Roja; Hoppe, Thorsten

    2011-03-01

    Protein ubiquitylation is a key post-translational control mechanism contributing to different physiological processes, such as signal transduction and ageing. The size and linkage of a ubiquitin chain, which determines whether a substrate is efficiently targeted for proteasomal degradation, is determined by the interplay between ubiquitylation and deubiquitylation. A conserved factor that orchestrates distinct substrate-processing co-regulators in diverse species is the ubiquitin-selective chaperone CDC-48 (also known as p97). Several deubiquitylation enzymes (DUBs) have been shown to interact with CDC-48/p97, but the mechanistic and physiological relevance of these interactions remained elusive. Here we report a synergistic cooperation between CDC-48 and ATX-3 (the Caenorhabditis elegans orthologue of ataxin-3) in ubiquitin-mediated proteolysis and ageing regulation. Surprisingly, worms deficient for both cdc-48.1 and atx-3 demonstrated extended lifespan by up to 50%, mediated through the insulin-insulin-like growth factor 1 (IGF-1) signalling pathway. As lifespan extension specifically depends on the deubiquitylation activity of ATX-3, our findings identify a mechanistic link between protein degradation and longevity through editing of the ubiquitylation status of substrates involved in insulin-IGF-1 signalling. © 2011 Macmillan Publishers Limited. All rights reserved

  11. El largo camino interior de Joseph Ratzinger (Notas sobre el libro "Jesús de Nazaret")

    OpenAIRE

    Mateo-Seco, L. F. (Lucas Francisco)

    2013-01-01

    J. Ratzinger ha ofrecido con su Jesús de Nazaret un importante legado teológico, madurado con los años, fruto de su estudio y de su vida interior. En él se conjugan de modo coherente meditación teológica e investigación exegética. Este artículo pone de relieve algunos de los aspectos más relevantes de la aportación de Ratzinger al estudio sobre Jesucristo. El A. destaca la perspectiva en la que se sitúa esta obra, en continuidad con las Vidas de Jesús de mediados del siglo XX, y caracterizada...

  12. Anatomy of an Article: A Film by Sylwester Zabielski and a Case Study by Joseph Janangelo

    Science.gov (United States)

    Zabielski, Sylwester; Janagelo, Joseph; Pearson, Jonathan; Hanlon-Baker, Patti; Greer, Jane

    2011-01-01

    This webtext examines the ways that Jonathan Pearson, a recent graduate of The University of Missouri-Kansas City, revised one of his essays to turn it from a seminar paper into a published scholarly article. The project covers a time period from 2004 to 2010 and documents the article's most important streams of input. Those streams include the…

  13. St Joseph's Hospital, Bon Secours Care Village, Mount Desert, Lee Road, Cork.

    LENUS (Irish Health Repository)

    Farrell, Eric

    2011-01-31

    Abstract Background Bone grafts are required to repair large bone defects after tumour resection or large trauma. The availability of patients\\' own bone tissue that can be used for these procedures is limited. Thus far bone tissue engineering has not lead to an implant which could be used as alternative in bone replacement surgery. This is mainly due to problems of vascularisation of the implanted tissues leading to core necrosis and implant failure. Recently it was discovered that embryonic stem cells can form bone via the endochondral pathway, thereby turning in-vitro created cartilage into bone in-vivo. In this study we investigated the potential of human adult mesenchymal stem cells to form bone via the endochondral pathway. Methods MSCs were cultured for 28 days in chondrogenic, osteogenic or control medium prior to implantation. To further optimise this process we induced mineralisation in the chondrogenic constructs before implantation by changing to osteogenic medium during the last 7 days of culture. Results After 8 weeks of subcutaneous implantation in mice, bone and bone marrow formation was observed in 8 of 9 constructs cultured in chondrogenic medium. No bone was observed in any samples cultured in osteogenic medium. Switch to osteogenic medium for 7 days prevented formation of bone in-vivo. Addition of β-glycerophosphate to chondrogenic medium during the last 7 days in culture induced mineralisation of the matrix and still enabled formation of bone and marrow in both human and rat MSC cultures. To determine whether bone was formed by the host or by the implanted tissue we used an immunocompetent transgenic rat model. Thereby we found that osteoblasts in the bone were almost entirely of host origin but the osteocytes are of both host and donor origin. Conclusions The preliminary data presented in this manuscript demonstrates that chondrogenic priming of MSCs leads to bone formation in vivo using both human and rat cells. Furthermore, addition of β-glycerophosphate to the chondrogenic medium did not hamper this process. Using transgenic animals we also demonstrated that both host and donor cells played a role in bone formation. In conclusion these data indicate that in-vitro chondrogenic differentiation of human MSCs could lead to an alternative and superior approach for bone tissue engineering.

  14. Three Experts on Quality Management: Philip B. Crosby, W. Edwards Deming, Joseph M. Juran

    Science.gov (United States)

    1992-07-01

    Department of the Navy Office of the Under Secretary of the Navy Total Quality Leadership Omce THREE EXPERTS ON QUALITY MANAGEMENT : PHILIP B. CROSBY W...research, as the "price of nonconformance." To aid managers in statistical theory , statistical thinking, and the application tracking the cost of doing...Quality Management emphasizes that the process must become a way of life in Theory of Systems. "A system is a series of the organization. Continuance is

  15. Euroopa hing / Joseph Ratzinger ; tõlk. Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Ratzinger, Joseph

    2005-01-01

    Paavst Benedictus XVI sõnul võib moraalsete väärtuste purunemine viia Euroopa identiteedi enesehävitamiseni. Inimväärikusest ja inimõigustest peab kujunema tingimusteta väärtus, ka on Euroopa identiteedi jaoks keskne tähtsus abielul ja perekonnal. Sõnavabadusel peab olema piir: teise inimese au ega väärikust ei tohi haavata

  16. Emi la Fafa / Mon Père et moi. Récit autobiographique de Joseph ...

    African Journals Online (AJOL)

    L'homme semble transférer tout son amour à sur son fils et aussi sur sa concubine préférée seulement parce qu'elle se consacre à l'enfant. Il travaille avec une application soutenue à l'éducation et au bien-être de son fils. Le fils finit par réaliser la sincérité et l'ardeur de l'amour de son père et lui rend de tout coeur son ...

  17. A designated centre for people with disabilities operated by St Joseph's Foundation, Limerick

    LENUS (Irish Health Repository)

    Billington, Jennifer

    2012-08-07

    AbstractBackgroundThe STRATIFY score is a clinical prediction rule (CPR) derived to assist clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-analysis is to determine the overall diagnostic accuracy of the STRATIFY rule across a variety of clinical settings.MethodsA literature search was performed to identify all studies that validated the STRATIFY rule. The methodological quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A STRATIFY score of ≥2 points was used to identify individuals at higher risk of falling. All included studies were combined using a bivariate random effects model to generate pooled sensitivity and specificity of STRATIFY at ≥2 points. Heterogeneity was assessed using the variance of logit transformed sensitivity and specificity.ResultsSeventeen studies were included in our meta-analysis, incorporating 11,378 patients. At a score ≥2 points, the STRATIFY rule is more useful at ruling out falls in those classified as low risk, with a greater pooled sensitivity estimate (0.67, 95% CI 0.52–0.80) than specificity (0.57, 95% CI 0.45 – 0.69). The sensitivity analysis which examined the performance of the rule in different settings and subgroups also showed broadly comparable results, indicating that the STRATIFY rule performs in a similar manner across a variety of different ‘at risk’ patient groups in different clinical settings.ConclusionThis systematic review shows that the diagnostic accuracy of the STRATIFY rule is limited and should not be used in isolation for identifying individuals at high risk of falls in clinical practice.

  18. St Joseph's Unit, Bantry General Hospital, Bantry General Hospital, Bantry, Cork.

    LENUS (Irish Health Repository)

    Trompet, Stella

    2011-10-06

    Abstract Background The PHArmacogenetic study of Statins in the Elderly at risk (PHASE) is a genome wide association study in the PROspective Study of Pravastatin in the Elderly at risk for vascular disease (PROSPER) that investigates the genetic variation responsible for the individual variation in drug response to pravastatin. Statins lower LDL-cholesterol in general by 30%, however not in all subjects. Moreover, clinical response is highly variable and adverse effects occur in a minority of patients. In this report we first describe the rationale of the PROSPER\\/PHASE project and second show that the PROSPER\\/PHASE study can be used to study pharmacogenetics in the elderly. Methods The genome wide association study (GWAS) was conducted using the Illumina 660K-Quad beadchips following manufacturer\\'s instructions. After a stringent quality control 557,192 SNPs in 5,244 subjects were available for analysis. To maximize the availability of genetic data and coverage of the genome, imputation up to 2.5 million autosomal CEPH HapMap SNPs was performed with MACH imputation software. The GWAS for LDL-cholesterol is assessed with an additive linear regression model in PROBABEL software, adjusted for age, sex, and country of origin to account for population stratification. Results Forty-two SNPs reached the GWAS significant threshold of p = 5.0e-08 in 5 genomic loci (APOE\\/APOC1; LDLR; FADS2\\/FEN1; HMGCR; PSRC1\\/CELSR5). The top SNP (rs445925, chromosome 19) with a p-value of p = 2.8e-30 is located within the APOC1 gene and near the APOE gene. The second top SNP (rs6511720, chromosome 19) with a p-value of p = 5.22e-15 is located within the LDLR gene. All 5 genomic loci were previously associated with LDL-cholesterol levels, no novel loci were identified. Replication in WOSCOPS and CARE confirmed our results. Conclusion With the GWAS in the PROSPER\\/PHASE study we confirm the previously found genetic associations with LDL-cholesterol levels. With this proof-of-principle study we show that the PROSPER\\/PHASE study can be used to investigate genetic associations in a similar way to population based studies. The next step of the PROSPER\\/PHASE study is to identify the genetic variation responsible for the variation in LDL-cholesterol lowering in response to statin treatment in collaboration with other large trials.

  19. Joseph A. Schumpeter's Theory of Social and Economic Evolution : a Reconstruction and Critique

    OpenAIRE

    Kovacs, György

    2008-01-01

    The book presents a reconstruction, interpretation and critical evaluation of the Schumpeterian theoretical approach to socio-economic change. The analysis focuses on the problem of social evolution, on the interpretation of the innovation process and business cycles and, finally, on Schumpeter s optimistic neglect of ecological-environmental conditions as possible factors influencing social-economic change. The author investigates how the Schumpeterian approach describes the process of socia...

  20. Archaeological Investigations at Site 45-OK-11, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    ethnographically known people, there was no taboo against eating porcupines (Ray 1932:90). Embroidery of porcupine quIll Is was used to decorate...University of Chicago Press, Chicago. ~ Wiimsen, E.N. 1968 Funct IonalI analIys is of flIaked stone art If acts. Amer Ican Ant Iqu Ity 33:156-161

  1. Joseph Constantine Carpue and the Bicentennial of the Birth of Modern Plastic Surgery.

    Science.gov (United States)

    Freshwater, M Felix

    2015-08-01

    September 2014 marked the bicentennial of the birth of modern plastic surgery. It was then that Carpue began a prospective observational study of nasal reconstruction that culminated in his 1816 monograph, which caused an explosion of interest in reconstructive surgery throughout Europe. In conducting his study, Carpue demonstrated ethical standards and the power of planning a procedure. His methods to document his results accurately would remain unsurpassed until photography was adopted at the end of the 19th century. Carpue took an apocryphal story of surgery performed in India more than twenty years earlier and transformed it into the beginning of modern plastic surgery. He succeeded in a number of unrecognized tasks that are themselves landmarks not only in plastic surgical history, but surgical history: devising the first prospective observational study, using exclusion criteria, maintaining appropriate patient confidentiality, setting a standard for preoperative disclosure and ethical approval over a century before these measures were codified, having independent documentation of his preoperative and postoperative findings, devising a method to objectively monitor and document the forehead flap, and describing the potential value of tissue expansion. He shared his experience by publishing his results and by lecturing in Europe. His contemporaries recognized him for his contributions and he was honored by election to the Royal Society. Carpue launched the modern era of plastic surgery in an ethical, logical, and objective manner. While plastic surgery has changed in the last two centuries, the principles that Carpue followed remain valid. © 2015 The American Society for Aesthetic Plastic Surgery, Inc.

  2. Archaeological Investigations at Sites 45-DO-242 and 45-DO-243, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    form of short-term camps. r . . . • . . . . • • . . . " " ’"" -- -- =’ ’= . .. .. .. -- - .: ,’ " ’’ " ’", "F,.,’," " ", ,:,,." " ".. ,. 188 ONOLOGY

  3. La razón en el cristianismo. Una reivindicación de Joseph Ratzinger

    OpenAIRE

    Blanco-Sarto, P. (Pablo)

    2005-01-01

    La raz6n supone un rasgo diferencial del cristianismo con respecto a otras religiones. La postura del cristianismo, segiin repite Ratzinger una y otra vez, es positiva y complementaria: la fe admite la critica de la raz6n, a la vez que el conocimiento humano se amplia y enriquece con la revelacion. El cristianismo admiti6 la filosofia, antes que las religiones: es lo que €\\ ha llamado «la victoria de la inteligencia» en el mundo de las religiones, y se ha d...

  4. Joseph A. Burton Forum Award Lecture: Managing Nuclear and Biological Risks: Building Resilience through International Cooperation

    Science.gov (United States)

    Pregenzer, Arian

    2012-03-01

    International technical cooperation has long been an important nonproliferation strategy, especially since the 1990s when cooperative threat reduction (CTR) to prevent theft or illicit transfer of nuclear weapons, material and expertise in the former Soviet Union became a keystone of U.S. policy. The CTR approach expanded to include engagement with scientists and engineers with expertise relevant to biological and chemical weapons, and continued in the 2000s with efforts in Iraq and Libya, and cooperation with a wide range of countries on export control and nuclear and biological security. In general, the goal of such efforts has been to prevent proliferation or WMD terrorism. In most cases, the United States (or the West) defines the threat, and then funds partner countries to implement solutions. This presentation will argue that the future requires a new approach. Nuclear capabilities are more widely available than ever before, repercussions of the A.Q. Khan network continue to unfurl, and countries such as the DPRK engage in illicit cooperation. In addition, there has been a global boom in biotechnology with many nations, particularly across South and East Asia, investing in the biotech industry as a source of fuels, food, and materials for their rapidly expanding populations. Compared to the 1990s, today's threat is more diffuse, and the line between legitimate and illegitimate technical capability is no longer so clear. In addition, the West has many fewer resources to invest due to the global economic downturn. In this environment, full commitment of all countries that benefit from nuclear and biological advances will be required to assure the safety and security of all. Technical cooperation can continue to play an important role, but with some significant changes: First, challenges should be defined from a local perspective to ensure full commitment and participation. Second, the goal of cooperation should shift from preventing specific threats to building general capabilities to respond to a broad range of challenges as they arise. Finally, the funding model for technical cooperation should move from contractual arrangements to mutual investment and partnership, with regional approaches encouraged to add credibility, increase available resources, and help to ensure broad support.

  5. Fatigue and Its Associated Factors in Spinocerebellar Ataxia Type 3/Machado-Joseph Disease.

    Science.gov (United States)

    Martinez, Alberto R M; Nunes, Marcelo B; Faber, Ingrid; D'Abreu, Anelyssa; Lopes-Cendes, Íscia; França, Marcondes C

    2017-02-01

    Fatigue has been described in several neurodegenerative diseases, reducing quality of life. A systematic evaluation of this clinical feature is lacking in SCA3/MJD. The aim of this study was to evaluate the frequency and the factors associated with fatigue in SCA3/MJD. Patients with SCA3/MJD and matched healthy controls answered the Modified Fatigue Impact Scale (MFIS), Beck Inventory Depression (BDI) and Epworth Sleepiness Scale (ESS). Scale for the assessment and rating of ataxia (SARA) was used to determine ataxia severity. We used Mann-Whitney and Fisher exact tests to compare mean scores and proportions between groups. Linear regression analyses were employed to investigate factors associated with fatigue in SCA3/MJD. Seventy-four patients were included with a mean age and disease duration of 47.2 ± 12.8 and 9.5 ± 6.37 years, respectively. There were 38 men and 36 women. Mean (CAG)n was 72.2 ± 3.8. Mean MFIS score was higher in patients with SCA3/MJD (41.4 ± 16.2 vs 18.4 ± 12.9, p < 0.001). According to BDI scores, relevant depressive symptoms were found in 69.4 % of patients but only in 10.4 % of controls (p < 0.001). The proportion of patients with ESS scores indicating excessive daytime somnolence was also higher than controls (37.5 vs 22.3 %, p = 0.05). In the multiple regression analysis, both BDI and ESS scores were associated with fatigue (r = 0.67, p < 0.001 and p = 0.01). Fatigue is frequent and strongly associated with depression and excessive daytime somnolence in SCA3/MJD.

  6. How successful was Joseph Stalin in establishing Soviet Union as a superpower?

    Directory of Open Access Journals (Sweden)

    Jakub Majkowski

    2017-07-01

    Full Text Available This essay will firstly address the extent of Stalin’s achievements in leading the course for domestic policy of the Soviet Union and its contribution towards maintaining the country’s supremacy in the world, for example the rapid post-war recovery of industry and agriculture, and secondly, the foreign policy including ambiguous relations with Communist governments of countries forming the Eastern Bloc, upkeeping frail alliances and growing antagonism towards western powers, especially the United States of America. The actions and influence of Stalin’s closest associates in the Communist Party and the effect of Soviet propaganda on the society are also reviewed. This investigation will cover the period from 1945 to 1953. Additionally, other factors such as the impact of post-war worldwide economic situation and attitude of the society of Soviet Union will be discussed.

  7. Archaeological Investigations at Nonhabitation and Burial Sites, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    from their limited pollen dispersal capabilities or their rather Infrequent appearance In the local vegetation. Except for Juglans . Plantago. and...associated with disturbed sites. Its occurence in one of the topsoil samples is not remarkable. The presence of either Juglans or Hippocastanea Is rather

  8. WHO ekspert : Eesti meditsiin vajab rahu / Joseph Kutzin ; interv. Sigrid Laev

    Index Scriptorium Estoniae

    Kutzin, Joseph

    2004-01-01

    WHO Euroopa tervisesüsteemide finantsnõustaja annab hinnangu Eesti meditsiinisüsteemi arengule ning leiab, et SKT-st tervishoiule eraldatud 5% ei ole meie sissetulekuga riigi puhul erandlik. Suureks probleemiks peab ta aidsi levikut. Lisa: Ressursid ammendumas

  9. Joseph M. Nyasani It is not only astronomers who have been ...

    African Journals Online (AJOL)

    about what lies beyond the planetary system and the extent of that reality in terms of the space it occupies. Philosophers have equally been baffled by this same question even though it may not be fair to draw a sharp distinction between philosophy and astronomy in certain material respects of inquiry. For, many classical or ...

  10. Rockets and feathers meet Joseph: Reinvestigating the oil-gasoline asymmetry on the international markets

    Czech Academy of Sciences Publication Activity Database

    Krištoufek, Ladislav; Luňáčková, P.

    2015-01-01

    Roč. 49, č. 1 (2015), s. 1-8 ISSN 0140-9883 R&D Projects: GA ČR(CZ) GP14-11402P Grant - others:GA ČR(CZ) GAP402/11/0948 Program:GA Institutional support: RVO:67985556 Keywords : Rockets and feathers * Asymmetry * Gasoline * Crude oil * Cointegration Subject RIV: AH - Economics Impact factor: 2.862, year: 2015 http://library.utia.cas.cz/separaty/2015/E/kristoufek-0452312.pdf

  11. The Interaction of Physics, Mechanics and Mathematics in Joseph Liouville's Research

    DEFF Research Database (Denmark)

    Lützen, Jesper

    2013-01-01

    Som for mange af hans samtidige var fysik og mekanik en stor inspirationskilde for Liouville's matematiske forskning. Laplaces tilgang til fysik var oprindelsen til Liouvilles teori om differentiation af vilkårlig orden, Kelvins elektrostatiske forskning var oprindelsen til Liouvilles sætning om ...

  12. [Gastric Cancer Diagnosed with Metastasis of the Navel(Sister Mary Joseph's Nodule) - A Case Report].

    Science.gov (United States)

    Katayama, Tomohiro; Ishii, Takaaki; Tono, Takeshi; Okubo, Yusuke; Shinozaki, Koji; Kawasaki, Yasuhito; Senba, Shuho; Yasuda, Seiji; Otsuru, Minoru

    2016-11-01

    A woman in her 60s was admitted to our hospital with pain and induration of the navel. She was diagnosed with gastric cancer with metastasis to the navel and underwent total gastrectomy and navel extraction. Because disseminated nodules were detected in the Douglas pouch and sigmoid colon, sigmoidectomy was performed to prevent bowel obstruction. The navel tumor was histologically diagnosed as a metastasis of the gastric cancer. One month after surgery, a chest skin tumor, which was also a skin metastasis of the gastric cancer[T4aN3M1(SKI, OTH)H0P1, fStage IV ], was detected, and tumor enucleation was performed. Enucleation was followed by 47 courses of systemic chemotherapy consisting of capecitabine, cisplatin, and trastuzumab. No recurrence or metastasis has been observed via FDG-PET/CT as of 5 years after surgery. Gastric cancer with peritoneal dissemination in addition to navel metastasis has been reported to have an extremely poor prognosis. However, long-term, recurrence-free survival was obtained in this case owing to aggressive surgical resection, followed by persistent systemic chemotherapy.

  13. Dialectical materialism and the construction of a new quantum theory: David Joseph Bohm, 1917-1992

    Energy Technology Data Exchange (ETDEWEB)

    Forstner, C.

    2005-07-01

    This paper touches on some general questions of theory construction in physics, by presenting a biographical case study of David Bohm through the perspective of Fleckian thought-collectives and their thought-style. In the 1920s a small elite of physicists established the Copenhagen Interpretation of quantum mechanics as a new thought-style in the thought-collective of the physicists. In the following decade the Copenhagen Interpretation was transferred from Europe to the USA, from one thought-collective into another, and was integrated into a specific American thought-style. David Bohm was initiated in this mode of thought during his undergraduate studies at the Pennsylvania State College and his graduate studies at Caltech and the University of California at Berkeley. (orig.)

  14. 76 FR 71374 - Joseph Giacchino, M.D.; Decision and Order

    Science.gov (United States)

    2011-11-17

    ....; Decision and Order On July 9, 2010, Administrative Law Judge (ALJ) Timothy D. Wing, issued the attached... its entirety including the ALJ's recommended decision, I have decided to adopt the ALJ's rulings... Administrative Law Judge Timothy D. Wing, Administrative Law Judge. This proceeding is an adjudication governed...

  15. 78 FR 50098 - Notice of Inventory Completion: St. Joseph County Sheriff's Department, Centreville, MI

    Science.gov (United States)

    2013-08-16

    ... detailed assessment of the human remains was made by the Michigan State University Forensic Anthropology... were transferred to the Michigan State University Forensic Anthropology Department where they were... American based on evaluation by the Michigan State University Forensic Anthropology Department. Pursuant to...

  16. Sister Mary Joseph nodule as the presenting sign of disseminated prostate carcinoma

    Directory of Open Access Journals (Sweden)

    Deb Prabal

    2009-01-01

    Full Text Available Sister Mary Joseph′s nodule is referred to as metastasis of visceral malignancy to the umbilicus. Most common primaries are in the gastrointestinal or genital tract, while other locations are rare. We recently encountered a 76-year-old male who was referred to the surgery clinic with an erythematous nodule in the umbilicus measuring 6 cm in diameter with complaints of painless profuse hematuria. History revealed severe obstructive voiding symptoms of 2-year duration, along with significant loss of weight and difficulty in walking. A detailed examination showed hard nodular hepatomegaly, along with grade IV prostatomegaly. Serum prostate-specific antigen was 3069 ng/ml. A pelvic radiograph displayed multiple osteolytic lesions, while ultrasonography showed multiple iso- and hypoechoic lesions in both lobes of the liver, suggestive of metastasis. Histopathology of a Tru-cut biopsy of the prostate confirmed an adenocarcinoma (Gleason score 9 with umbilical metastasis. The patient was on regular follow-up and died 3 months later.

  17. Profiles in medical courage: Joseph Goldberger, the sharecropper’s plague, science and prejudice

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2012-06-01

    Full Text Available No abstract available. Article truncated at 150 words. “You must accept the truth from whatever source it comes”. -MaimonidesThe Sharecropper’s PlagueIn the early half of the twentieth century a mysterious disease, “the sharecropper’s plague”, reached epidemic proportions in the Southern US (1. Each state decided whether it would recognize and publicly admit the existence of what was then considered an embarrassment. The total number of new annual cases was estimated as about 75,000 in 1915 and about 100,000 throughout the 1920s (2. The disease had a 40% mortality rate, and many survivors with dementia were confined to mental institutions (3. Patients initially presented with symmetrically reddened skin, similar to that produced by a sunburn or poison oak. Later, the dermatitis turned rough and scaly in one or more locations, such as the hands, the tops of the feet, or the ankles, or in a butterfly-shaped distribution across the nose. Disturbances of the digestive tract and the …

  18. Maksame arengumaadele metsade hoidmise eest hüvitist / Joseph E. Stiglitz

    Index Scriptorium Estoniae

    Stiglitz, Joseph E.

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti 15. juuni lk. 10. Autor usub, et G-8 riigid peaksid heaks kiitma idee, et hüvitades arengumaadele nende pakutavad keskkonnateenused, suurendavad jõukad riigid vaestele antavat abi, samuti soodustavad õiget turumajanduslikku mõtlemist. Vihmametsade kaitsmise vajadusest

  19. Archaeological Investigations at Site 45-DO-326, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    Quartz Bone/antLer ATTRIBUITE Us: TMI0WIeSS 2 DentaL iuw Och re PRakeam thickness is taken at the Indeterminate thickest point on the object, excluding the...where this material type constitutes 58.6% of the total. Bone and antler artifacts are rare, and only one dental lum shell was recovered from Zone 1...flake size by materiall by zone, 45-DO-326. Size (in) by Zone materist Totat 1 2 3 4 Jasper M1/4 904 1,070 1,296 6S4 3,914 0/4 1 3 1 7 12 ChaLcedony

  20. New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado-Joseph disease)

    NARCIS (Netherlands)

    Rueb, Udo; Brunt, Ewout R.; Deller, Thomas

    Purpose of review This review summarizes recent neuropathological findings in spinocerebellar ataxia type 3 and discusses their relevance for clinical neurology. Recent findings The extent of the spinocerebellar ataxia type 3 related central nervous neurodegenerative changes has been recently

  1. 1996 Joseph E. Whitley, MD, Award. Evaluation of an introductory course in chest radiology.

    Science.gov (United States)

    Collins, J

    1996-12-01

    The author developed and evaluated the effectiveness of an educational program for teaching the fundamentals of chest radiology to radiology residents. Nineteen radiology residents completed a course that consisted of 17 1-hour chest radiology conferences. All seven 1st-year radiology residents were required to attend every conference; more senior-level residents were encouraged to attend, but their attendance was not mandatory. All conferences were given by the same instructor with the use of a didactic slide and radiograph presentation, videotape, heart-lung model, and a 120-page syllabus. Residents were encouraged to participate in a daily quiz. Resident learning was measured by means of a pre- and postcourse examination. Conference attendance rate was 93% for 1st-year residents and 75% for more senior residents. Nineteen residents took both the pre- and postcourse examination; mean scores increased from 65.6% to 86.2% (P effective means of learning the basics of chest radiology. The residents were in support of making this course a required part of the residency curriculum.

  2. The relationship between Marcel Proust and Joseph Babinski: the encounter of two geniuses

    Directory of Open Access Journals (Sweden)

    José Luiz Pedroso

    2014-06-01

    Full Text Available Marcel Proust was one of the greatest French writers of all times. Since early in his life, Proust was interested in arts and particularly literature. He also demonstrated a great knowledge of medicine, particularly neurology. His father was a doctor, and contributed to neurology through studies on aphasia, stroke, hysteria, and neurasthenia. During his childhood, Proust had the first asthma attack, initially considered a manifestation of neurasthenia. Regarding his illness, Proust was in touch with several renowned neurologists, such as Brissaud, Babinski and Sollier, and other disciples of Charcot. Proust spent the last three years of his life mostly confined to his bedroom since his health had badly deteriorated. In one moment, Babinski was called, examined Proust and after leaving his bedroom, announced to his brother that Proust was practically dead. Few hours later, Proust developed vomica and died.

  3. Degeneration of the external cuneate nucleus in spinocerebellar ataxia type 3 (Machado-Joseph disease)

    NARCIS (Netherlands)

    Rub, U; de Vos, RAI; Brunt, ER; Schultz, C; Paulson, H; Del Tredici, K; Braak, H

    2002-01-01

    Owing to its anatomical connections, the external cuneate nucleus (ECU) plays a crucial role in processing proprioceptive input from the upper trunk and upper limbs. Here, we studied this dorsal column nucleus post-mortem in five individuals with clinically diagnosed and genetically confirmed

  4. Kafka's trial dilemma: proposal of a practical solution to Joseph K.'s unknown accusation.

    Science.gov (United States)

    de Oliveira, Irismar Reis

    2011-07-01

    Numerous interpretations have been proposed to Kafka's writings, due to their hermetic nature. Psychological interpretations have been the object of numerous psychoanalytical studies, but not of cognitive-behavioral therapy (CBT) studies; nor have there been attempts to propose a solution to Kafka's inner conflicts supposedly pictured by his characters. In this paper, I assume that Kafka intended to propose a universal principle of self-accusation by human beings. I also assume that self-accusations occur as schemas and core beliefs about the self described by cognitive therapists, and that being aware of such cognitions might permit the patient to organize his or her own defense. Thus, it is possible to set an enquiry to identify the self-accusations and mobilize the characters in the inner tribunal to help the patient judge himself with a more realistic and informed basis. Empirical data supporting this hypothesis as well as the approach I proposed to deal with it are presented in this paper. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. Joseph et al., Afr J Tradit Complement Altern Med. (2013) 10(5):299 ...

    African Journals Online (AJOL)

    AJTCAM

    Blood samples were collected and allowed to clot at room temperature. The blood samples were centrifuged .... hepatocellular carcinoma induction. It could be reversed significantly (p < 0.05) by this Ayurvedic preparation and was .... Izzo, A. A. and Capasso, F. (1999). Flavonoids: old and new aspects of a class of natural.

  6. 78 FR 66801 - Norfolk Southern Railway Company-Abandonment Exemption-in St. Joseph County, Ind.

    Science.gov (United States)

    2013-11-06

    ... use/rail banking requests under 49 CFR 1152.29 must be filed by November 18, 2013.\\3\\ Petitions to... rights-of-way for the Line, which could affect future public use should NSR consummate the proposed.... Environmental, historic preservation, public use, or trail use/rail banking conditions will be imposed, where...

  7. A Linguistic Study of Joseph Edoki's The African Dream *Grace I ...

    African Journals Online (AJOL)

    unlike the Asian Tigers such as Malaysia, Indonesia, Indian and ... stop shifting the blame of underdevelopment to “slavery, .... The fundamental question which is rhetorical is “what is our problem”? Edoki does not leave the reader to go on endless search for what the problem could be but notes through insight that the.

  8. Umbilical metastasis (Sister Mary Joseph's nodule diagnosed by fine-needle aspiration

    Directory of Open Access Journals (Sweden)

    Tatomirović Željka

    2004-01-01

    Full Text Available Sister Mary Joseph’s nodule is the eponym for metastatic involvement of the umbilicus. This less common entity is the sign of disseminated malignant disease, mainly of digestive and gynecologic origin, and is associated with a poor prognosis. A case of Sister Mary Joseph’s nodule in a 76-year-old woman in whom the umbilical metastasis was the first sign of malignant disease in presented. The diagnosis of metastatic adenocarcinoma was established by fine needle aspiration cytology of the umbilical nodule. Radiological and ultrasonographic investigation disclosed carcinoma of the gallbladder with pancreas, stomach, and colon invasion as well as peritoneal dissemination. The diagnosis was confirmed by exploratory laparatomy and histological examination of the excised umbilical nodule.

  9. Archaeological Investigations at Site 45-DO-214, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    A Feathered chipping, smoothing; bifecisL end point ProjectiLe Hide, Bone N/A Tip burination, striations, Impact BoiL, Stone hinge fracture ’ Adapted...wood cell walls. Three other fragments found in the same wrapping show marks of artiflcal cutting or trimming, as well as compression fractures across...fragments, 1 radius fragment, 2 ulnas, 1 ulna fragment, Incisor, 1 first phalanx, 1 calcaneus , I mandible fragment. Zone 4: 18 mandible fragments, I

  10. Dysautonomia is frequent in Machado-Joseph disease: clinical and neurophysiological evaluation.

    Science.gov (United States)

    Takazaki, Karen A G; D'Abreu, Anelyssa; Nucci, Anamarli; Lopes-Cendes, Iscia; França, Marcondes C

    2013-08-01

    Autonomic dysfunction has been already described in patients with SCA3/MJD, but several important questions remain unanswered. The objectives of this study are to determine the frequency and the intensity of autonomic manifestations in SCA3/MJD, as well as to identify possible correlations between autonomic manifestations and genetic and clinical parameters. We have performed clinical and electrophysiological evaluations of 40 patients with SCA3/MJD and 38 healthy controls. We used the Scale for the Assessment and Rating of Ataxia (SARA) and the scales for Outcomes in Parkinson's Disease: Autonomic Questionnaire to quantify the severity of ataxia and autonomic complaints, respectively. We also studied heart rate variability at rest, during orthostatic challenge (30:15 ratio), Valsalva maneuver (Valsalva index), and deep breathing (E/I ratio). We evaluated spectral analyses of RR intervals at rest and the sympathetic skin response. Mean RR intervals at rest and the 30:15 ratio were different between patients and controls (811.8 versus 933.4 ms; p = 0.001 and 1.10 versus 1.15; p = 0.038, respectively). The Valsalva index and the E/I ratio were similar between the groups (p = 0.373 and p = 0.08). Spectral analysis presented distinct results in patients and controls, related to low- and high-frequency power (p < 0.001 and <0.001, respectively). We found cardiovascular and sympathetic sweat disautonomia in 30 % and 45 % of the patients with SCA3/MJD. Autonomic manifestations were related neither to genetic (CAG repeat length) nor clinical parameters (age, disease duration, SARA scores). Autonomic dysfunction is frequent and sometimes disabling in SCA3/MJD. We found evidence of both cardiovascular and sudomotor dysfunction in the disease.

  11. A designated centre for people with disabilities operated by St Joseph's Foundation, Limerick

    LENUS (Irish Health Repository)

    Shi, Weifeng

    2010-12-01

    More and more nucleotide sequences of type A influenza virus are available in public databases. Although these sequences have been the focus of many molecular epidemiological and phylogenetic analyses, most studies only deal with a few representative sequences. In this paper, we present a complete analysis of all Haemagglutinin (HA) and Neuraminidase (NA) gene sequences available to allow large scale analyses of the evolution and epidemiology of type A influenza.

  12. Archaeological Investigations at Sites 45-OK-287 and 45-OK-288, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    sediments, and perhaps one tlood deposit, with an alluvial fan building In the draw. These upper deposits were def Ined as a separate zone, Zone 1, at 45...there Is no - build -up ot charcoal or other Indications of prolonged fIring. The floor Itself yielded two radiocarbon dates of 1046±69 B.P. (TX-4030...of the state of Washington. In Contributions to the U.S. National Herbarium (Vol. II). U.S. Government Printing Office, *. -. Washington, D.C. .1

  13. 3 BB Joseph Yoruba Concept of Evil pp55-73

    African Journals Online (AJOL)

    REGINALDS

    philosophical (often metaphysical) relevance to the concrete existence of individual persons. ... Moral evil, on the other hand, covers all undesirable things for which human beings are responsible, including strife, theft, promise breaking, lying, murder, conspiracy and other such human- .... assumption of presidential duties.

  14. The Ethics of Joseph Fletcher And His Views Of Genetic control

    OpenAIRE

    Fru, Fidelis Chungong

    2004-01-01

    As we approach the 21st Century, our society is increasingly being faced with technological advances. One of such areas of advancement is the reasearch involving human genes. The human genome-mapping project(HGMP) started on the first of october 1990 with a group of over 350 labs. but by late 90's, many important advances had been discovered concerning how to improve the human specie. With these advances came ethical questions and concerns.Both moral and legal questions have been raised as to...

  15. A designated centre for people with disabilities operated by St Joseph's Foundation, Cork

    LENUS (Irish Health Repository)

    McNabola, Aonghus

    2009-02-01

    According to World Health Organisation figures, 30% of all cancer deaths, 20% of all coronary heart diseases and strokes and 80% of all chronic obstructive pulmonary disease are caused by cigarette smoking. Environmental Tobacco Smoke (ETS) exposure has also been shown to be associated with disease and premature death in non-smokers. In response to this environmental health issue, several countries have brought about a smoking ban policy in public places and in the workplace. Countries such as the U.S., France, Italy, Ireland, Malta, the Netherlands, Sweden, Scotland, Spain, and England have all introduced policies aimed at reducing the population exposure to ETS. Several investigations have monitored the effectiveness of these smoking ban policies in terms of ETS concentrations, human health and smoking prevalence, while others have also investigated a number of alternatives to smoking ban policy measures. This paper reviews the state of the art in research, carried out in the field of ETS, smoking bans and Tobacco Control to date and highlights the need for future research in the area.

  16. Archaeological Investigations at Sites 45-OK-250 and 45-OK-4, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    Officer and the Advisory Council on Historic Preservation, esta 1lished an interim Memorandum of Agreement under which full-scale excavations at those six...fragments. Zone 13: 5 mandibles, 6 mandible fragments, 1 scapula fragment, 1 humerus, 1 uina fragment, 1 tibia. Zone 14: 2 skull, 2 mandibles, 4

  17. nkereuwem W. ebiti,1 Joseph o. ike,2 taiwo l. Sheikh,1 Dupe M ...

    African Journals Online (AJOL)

    The objective of the study was to identify the prevalence of psychoactive substance use among incarcerated delinquents in Nigeria and its determinants. The total inmate population of 401 individuals were interviewed over a period of four weeks using an interviewer administered questionnaire that assessed for socio ...

  18. A designated centre for people with disabilities operated by St Joseph's Foundation, Cork

    LENUS (Irish Health Repository)

    Pinhasi, Ron

    2010-01-01

    In 2008, a well preserved and complete shoe was recovered at the base of a Chalcolithic pit in the cave of Areni-1, Armenia. Here, we discuss the chronology of this find, its archaeological context and its relevance to the study of the evolution of footwear. Two leather samples and one grass sample from the shoe were dated at the Oxford Radiocarbon Accelerator Unit (ORAU). A third leather sample was dated at the University of California-Irvine Accelerator Mass Spectrometry Facility (UCIAMS). The R_Combine function for the three leather samples provides a date range of 3627-3377 Cal BC (95.4% confidence interval) and the calibrated range for the straw is contemporaneous (3627-3377 Cal BC). The shoe was stuffed with loose, unfastened grass (Poaceae) without clear orientation which was more than likely used to maintain the shape of the shoe and\\/or prepare it for storage. The shoe is 24.5 cm long (European size 37), 7.6 to 10 cm wide, and was made from a single piece of leather that wrapped around the foot. It was worn and shaped to the wearer\\'s right foot, particularly around the heel and hallux where the highest pressure is exerted in normal gait. The Chalcolithic shoe provides solid evidence for the use of footwear among Old World populations at least since the Chalcolithic. Other 4th millennium discoveries of shoes (Italian and Swiss Alps), and sandals (Southern Israel) indicate that more than one type of footwear existed during the 4th millennium BC, and that we should expect to discover more regional variations in the manufacturing and style of shoes where preservation conditions permit.

  19. God's Holy Spirit: A back-story from the Joseph narrative (Genesis ...

    African Journals Online (AJOL)

    With the help of the philosopher/theorist Mikhail Bakhtin, the narrated experience of the character in seven scenes is examined for evidence of Judah's journey of transformation – presumably guided by God's widening and inspiring Spirit, with special attention given to the scene (Genesis 44) where Judah must persuade his ...

  20. Lapiku maailma haprus / Joseph S. Nye ; tõlk. Liis Auväärt

    Index Scriptorium Estoniae

    Nye, Joseph S.

    2006-01-01

    Ilmunud ka: Molodjozh Estonii 28. aug. lk. 6-7. Käsitledes globaliseerumist ja Thomas Friedmani lapiku maa metafoori, ütleb autor, et ka 1914. oli maailmamajandus äärmiselt integreeritud, kuid vastastikune majanduslik sõltuvus vähenes järgmise 30 aasta jooksul, muutudes ühtseks alles 70-ndatel. Mõnede arvates mängib Hiina tänapäeval sama rolli, mida mängis Saksamaa XX sajandil. Oht lapikule maale tuleb mitteriiklikelt jõududelt

  1. Amerikanskaja vneshnjaja politika posle Iraka / Joseph S. Nye ; tõlk. Nikolai Zhdanovitsh

    Index Scriptorium Estoniae

    Nye, Joseph S.

    2007-01-01

    Kitsaskohtadest USA sise- ja välispoliitikas, millele on tähelepanu juhtinud Iraagi sõda, 2008. aasta presidendivalimistest, kodanikuühiskonna ja demokraatia edasisest arengust Ameerika Ühendriikides

  2. Poiti dalshe Ramsfelda / Joseph S. Nye ; tõlk. Nikolai Zhdanovitsh

    Index Scriptorium Estoniae

    Nye, Joseph S.

    2006-01-01

    USA kongressi vahevalimistel saadud kaotus ning Iraagi sõja kriitika viis kaitseminister Donald Rumsfeldi tagasiastumiseni. USA võitlus terrorismiga ja sündmused Iraagis osutavad, et pealesunnitud demokraatial on piirid. Sise- ja välispoliitilised probleemid ning parteide koostöö

  3. Väikesed suured mehed / Joseph Nye ; tõlk. Priit Simson

    Index Scriptorium Estoniae

    Nye, Joseph

    2008-01-01

    Autor väljendab mõtet, et ühiskonnad, mis tuginevad nn, kangelasjuhtidele, arendavad kodanikuühiskonda ja sotsiaalset kapitali liiga aeglaselt, et olla võimelised juhtima tänapäeva võrgustunud maailma ning ei tule toime infoühiskonna väljakutsetega

  4. Usmirenije Severnoi Korei / Joseph S. Nye ; tõlk. Nikolai Zhdanovitsh

    Index Scriptorium Estoniae

    Nye, Joseph S.

    2006-01-01

    USA president George Bush lootis, et tal õnnestub Põhja-Korea tuumaprobleemi lahendada režiimi vahetamisega. Arvestati, et isolatsioon ja sanktsioonid viivad Kim Jong Il'i diktatuuri kukutamiseni. Kuna režiim osutus vastupidavaks, nõustuti kuuepoolsete läbirääkimistega Hiina, Venemaa, Jaapani ja mõlema Koreaga

  5. Fashion clothing involvement, opinion leadership and opinion seeking amongst black generation Y students / Pulaki Joseph Tshabalala

    OpenAIRE

    Tshabalala, Pulaki Joseph

    2014-01-01

    Opinion leadership and opinion seeking are central constructs in academic studies of new product innovations. Fashion opinion leaders as those individuals who accelerate the fashion maturity process by legitimising a fashionable trend and influence other consumers to adopt the new innovative style as a replacement for the current accepted one. Consumers who accept information and adopt new style innovations are called opinion seekers and are important to the diffusion of new fashions because ...

  6. A designated centre for people with disabilities operated by St Joseph's Foundation, Cork

    LENUS (Irish Health Repository)

    Ryan, C Anthony

    2010-03-17

    Abstract Background A number of recent developments in medical and nursing education have highlighted the importance of communication and consultation skills (CCS). Although such skills are taught in all medical and nursing undergraduate curriculums, there is no comprehensive screening or assessment programme of CCS using professionally trained Standardized Patients Educators (SPE\\'s) in Ireland. This study was designed to test the content, process and acceptability of a screening programme in CCS with Irish medical and nursing students using trained SPE\\'s and a previously validated global rating scale for CCS. Methods Eight tutors from the Schools of Nursing and Medicine at University College Cork were trained in the use of a validated communication skills and attitudes holistic assessment tool. A total of forty six medical students (Year 2 of 5) and sixty four nursing students (Year 2\\/3 of 4) were selected to under go individual CCS assessment by the tutors via an SPE led scenario. Immediate formative feedback was provided by the SPE\\'s for the students. Students who did not pass the assessment were referred for remediation CCS learning. Results Almost three quarters of medical students (33\\/46; 72%) and 81% of nursing students (56\\/64) passed the CCS assessment in both communication and attitudes categories. All nursing students had English as their first language. Nine of thirteen medical students referred for enhanced learning in CCS did not have English as their first language. Conclusions A significant proportion of both medical and nursing students required referral for enhanced training in CCS. Medical students requiring enhanced training were more likely not to have English as a first language.

  7. Archaeological Investigations at 30 Historic Sites, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    124 Figure 7-5. Excavation units at Condon Ferry trading post (45-DO-202H) ....... ....................... ... 125 Figure 7-6. Yellow brown alcoholic...lid and blue and yellow letters, Including "...UNION LEAGUE," surrounded by a green and yellow design. CM., ~PR T~ cm.’: Figure 5-3. Lid from resealable...from a catalog and some of wallpaper , were found. The 12 wallpaper pieces, all of the same crosshatched brown design, were found in Unit 16NOE along

  8. 77 FR 14441 - Facility Operating License Amendment From Southern Nuclear Operating, Inc., Joseph M. Farley...

    Science.gov (United States)

    2012-03-09

    ... the non- seismically qualified piping of the Spent Fuel Pool (SFP) purification system may be... evaluated? Response: No. The use of the [Boric Acid Recovery System] BARS system and the SFP Purification... reactor coolant system or main steam system piping. Therefore, the connection of the SFP Purification Loop...

  9. Politics of Deceit and Reality in Africa: A Study of Joseph Edoki's ...

    African Journals Online (AJOL)

    Politics and political activities have been very important issues that most critics and literary writers have devoted their attention in Africa. Political matter is a very prominent topic of contemporary scholarship. This is due to the fact that African literary works, being reflections of the debased and unholy political activities of the ...

  10. ЛІКАР-ХІРУРГ-ПЕДАГОГ-КОМПОЗИТОР ЗНАНИЙ В УСЬОМУ СВІТІ ЙОСИП МОЙСЕЙОВИЧ ЕЛЬГІСЕР / Doctor-Surgeon-Teacher-Composer, Worldwide Known – Joseph Moyseyovych Elhiser

    Directory of Open Access Journals (Sweden)

    Чебан Василь

    2014-12-01

    Full Text Available Cheban Vasyl. Doctor-Surgeon -Teacher - Composer, Worldwide Known - Joseph Moyseyovych Elhiser. The article presents some material on graduate Chernovtsy State Medical Institute (now BSMU surgeon - a talented musician, composer, teacher, winner of piano competition, having won the UNESCO honored art and analyzes individual pages of his work and life. Key words: surgeon, composer, teacher, musician, winner of the competition. Cheban Vasyl. MÉDECIN – CHIRURGIEN-PROFESSEUR-COMPOSITEUR CONNU DANS LE MONDE ENTIER JOSEPH MOYSEYOVYCH CELHISER L'article présente une documentation sur les études supérieures du diplomé de l’ Institut d'Etat de médicine de Tchernivtsi (maintenant l’Université d'Etat de médicine de Tchernivtsi chirurgien – un musicien talentueux, compositeur, professeur, lauréat du concours de piano, vainqueur de la médaille d'or de l'UNESCO, honoré travailleur des Arts et les pages individuelles. On a analysé son travail et sa vie créative. Mots clés: chirurgien, compositeur, professeur, musicien, lauréat du concours. Чебан Василий. ВРАЧ - ХИРУРГ- ПЕДАГОГ-КОМПОЗИТОР ИЗВЕСТЕН ВО ВСЕМ МИРЕ ИОСИФ МОИСЕЕВИЧ ЭЛЬГИСЕР. В статье приведены отдельные материалы о выпускнике Черновицкого государственного медицинского института (ныне БГМУ враче-хирурге – талантливом музыканте, композиторе, педагоге, лауреате конкурса пианистов, обладателе золотой медали ЮНЕСКО, заслуженном деятеле искусств и проанализировано отдельные страницы его творчества и жизни. Ключевые слова: врач-хирург, композитор, педагог, музыкант,

  11. South African Journal of Obstetrics and Gynaecology - Vol 12, No 1 ...

    African Journals Online (AJOL)

    Seroprevalence of rubella antibodies among antenatal patients in the Western Cape · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Craig Corcoran, Diana R Hardie, 26-28 ...

  12. L’entrepreneur, éléments d’une analyse parallèle Léon Walras / joseph alois Schumpeter (The entrepreneur, elements for a paralell analysis Leon Walras / joseph alois Schumpeter)

    OpenAIRE

    Sophie BOUTILLIER

    2010-01-01

    L. Walras, comme J. A. Schumpeter, avaient la même ambition : révolutionner la théorie économique. Ils atteignent cet objectif par des voies différentes (le premier par les mathématiques, le second par l’analyse sociohistorique). Ils formulent ainsi deux théories différentes de l’entrepreneur, agent économique central du capitalisme. Le modèle de Walras est statique. L’entrepreneur est rationnel par son comportement maximisateur. Le modèle de Schumpeter est dynamique. L’entrepreneur est le mo...

  13. The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53

    Science.gov (United States)

    Liu, Hongmei; Li, Xiaoling; Ning, Guozhu; Zhu, Shu; Ma, Xiaolu; Liu, Xiuli; Liu, Chunying; Huang, Min; Schmitt, Ina; Wüllner, Ullrich; Niu, Yamei; Guo, Caixia; Wang, Qiang; Tang, Tie-Shan

    2016-01-01

    As a deubiquitinating enzyme (DUB), the physiological substrates of ataxin-3 (ATX-3) remain elusive, which limits our understanding of its normal cellular function and that of pathogenic mechanism of spinocerebellar ataxia type 3 (SCA3). Here, we identify p53 to be a novel substrate of ATX-3. ATX-3 binds to native and polyubiquitinated p53 and deubiquitinates and stabilizes p53 by repressing its degradation through the ubiquitin (Ub)-proteasome pathway. ATX-3 deletion destabilizes p53, resulting in deficiency of p53 activity and functions, whereas ectopic expression of ATX-3 induces selective transcription/expression of p53 target genes and promotes p53-dependent apoptosis in both mammalian cells and the central nervous system of zebrafish. Furthermore, the polyglutamine (polyQ)-expanded ATX-3 retains enhanced interaction and deubiquitination catalytic activity to p53 and causes more severe p53-dependent neurodegeneration in zebrafish brains and in the substantia nigra pars compacta (SNpc) or striatum of a transgenic SCA3 mouse model. Our findings identify a novel molecular link between ATX-3 and p53-mediated cell death and provide an explanation for the direct involvement of p53 in SCA3 disease pathogenesis. PMID:27851749

  14. Archaeological Investigations at Sites 45-OK-2 and 45-OK-2A, Chief Joseph Dam Project, Washington.

    Science.gov (United States)

    1984-01-01

    and shaped tools. The sheer diversity of the assemblages suggests that bone tool manufacturing was accomplished at the site. Two kinds of systematic...flotation sample from charcoal flecked soil around and under a wood concentration on the floor of Feature 49, contained a charred larch piano -convex point

  15. Arsenic and Old Mustard: Chemical Problems of Old Arsenical and 'Mustard' Munitions (Joseph F. Bunnett and Marian Mikotajczyk, Eds.)

    Science.gov (United States)

    Garrett, Benjamin

    1999-10-01

    What do Knute Rockne, Notre Dame's famed football coach, and Lewisite, a chemical warfare agent dubbed "the dew of death", have in common? Both owe their discovery to Father Julius Arthur Nieuwland.1 Rockne's legacy lives on in the Fighting Irish and their tradition of excellence on the gridiron. Lewisite, together with other arsenical- and mustard-type chemical warfare agents, provide a legacy that lives on, too, but with less cheerful consequences. The book Arsenic and Old Mustard: Chemical Problems of Old Arsenical and 'Mustard' Munitions makes clear the challenges faced in dealing with those consequences. This book documents the proceedings of a workshop devoted to arsenical- and mustard-type chemical warfare agents and their associated munitions. The workshop, held in Poland in 1996, included nine lectures, eight posters, and three discussion groups; and the contents of all these are presented. Major support for the workshop came from the Scientific Affairs Division of NATO as part of on ongoing series of meetings, cooperative research projects, and related efforts dealing with problems leftover from the Cold War and, in the case of the arsenicals and mustards, from conflicts dating to World War I. These problems can be seen in contemporary accounts, including a January 1999 news report that the U.S. Department of Defense intends to survey Washington, DC, areas near both American University and the Catholic University of America (CUA), site of the original synthesis of Lewisite, for chemical warfare agents and other materials disposed at the end of World War I.2 The first nine chapters of the book present the workshop's lectures. Of these, readers interested in chemical weapon destruction might find especially useful the first chapter, in which Ron Mansley of the Organisation for the Prohibition of Chemical Weapons presents a scholarly overview covering historical aspects of the arsenicals and mustards; their production and use; prospective destruction technologies; and international obligations attendant to the Chemical Weapons Convention, which entered into force in 1997. Hermann Martens's presentation of German arsenical and mustard munitions and of technical approaches to their destruction is similarly detailed, thorough, and engaging. W. R. Cullen's chapter "Arsenic in the Environment" and Shigeru Maeda's chapter "Biotransformation of Arsenic in Freshwater Organisms" help place the problems associated with the arsenicals in their environmental context and, hence, should appeal to a large audiencenot merely those specialists dealing with chemical weapon destruction. The reports of the three discussion groupsYperite,3 Arsenicals, and Recovered Munitionsprovide useful summaries of current knowledge and needs for additional research. The Arsenicals report observes that "destruction of arsenical agents appears to have received little attention." This situation may change if searches in Washington, DC, should uncover caches of old arsenicals at CUA and, especially, when the governments of the People's Republic of China and Japan agree on funding for destruction of the chemical munitions Japan caused to be abandoned on what is now the territory of the PRC. A conservative estimate is that there are 2,000,000 of these abandoned munitions, most of them being arsenicals and mustards.4 Notes and References 1. Nieuwland (1878-1936) hired Rockne in 1914 as a chemistry instructor. According to Father Nieuwland, Rockne owed much of his prowess as one of the greatest coaches of all time to his training in chemistry, which taught him the method of reasoning (Ind. Eng. Chem. New Ed., April 20, 1931). W. Lee Lewis, Lewisite's eponym, credits Nieuwland's unpublished dissertation as the source for his 1918 synthesis (Lewis, W. L.; Perkins, G. A. The beta-Chlorovinyl Chloroarsines; Ind. Eng. Chem. 1923, 15, 290-295). Lewisite itself is actually the group of mono-, di-, and tri-substituted 2-chloroethenyl derivatives of arsenic(III) chloride. 2. Vogel, S. Search to Resume near AU for WWI Chemicals; Washington Post, January 24, 1999, page C01. 3. Yperite is a trivial name for sulfur mustard or bis(2-chloroethyl) sulfide. The name honors Ypres, Belgium, where the Germans first used sulfur mustard as a chemical weapon on July 12, 1917. 4. Zhao, L. Two Scenes of Poisonous Shells Left Over by Japan in Dunhua, Jilin Province; presented at the Fifth International Symposium on Sino-Japan relations over the past 100 years, Changchun, PRC, September 23-29, 1998.

  16. Andmete kogumise ja süstematiseerimise kontekstuaalsed strateegiad / Joseph Hanson Kwabena Nketia ; tõlk. Anne Lange

    Index Scriptorium Estoniae

    Kwabena Nketia, Joseph Hanson

    2005-01-01

    Aafrika muusikateadlase, etnomusikoloogi käsitlus kontekstist. Lühendatud tõlge artiklist "Contextual Strategies of Inquiry and Systematization" (Ethnomusicology, Journal of the Society for Ethnomusicology). Järgneb nr. 6, lk. 66-75

  17. Providing Worker Education and Building the Labor Movement: The Joseph S. Murphy Institute of City University of New York

    Science.gov (United States)

    D'Amico, Deborah

    2011-01-01

    To provide equitable access to formal, nonformal and workplace learning, experts urge community, business, education and government partnerships. While membership in unions continues to decline and "opportunities for entry-level workers to become skilled workers is lessening," the partnership described in this article shows that it is…

  18. Küpsemas on uus kunstiskandaal : vene kuraator Joseph Backstein on kuulsustest kokku pannud omaette biennaali / Ants Juske

    Index Scriptorium Estoniae

    Juske, Ants, 1956-2016

    1998-01-01

    Tallinnas Eesti Kunstimuuseumis avati külalisnäitus 'Medialisatsioon', kus on eksponeeritud Oleg Kuliku, Moskva rühmituse AES, Andres Serrano New Yorgist, Zhou Tiehai Shanghaist jt., kokku üle 20 kunstniku meedialooming. Ando Keskküla kommentaar

  19. Joseph Carpentier: pionero de la fotografía estereoscópica sobre España

    OpenAIRE

    Sánchez Gómez, Carlos; Fernández-Rivero, Juan-Antonio

    2011-01-01

    During the 1850s and 1860s begins in London and Paris a major photographic industry around the newly invented stereoscopic view. Photographers and editors travel across countries to collect the cities and most important monuments with their cameras. To Spain, as all countries, arrived many photographers travelers, but a small number of them, French, would make a complete urban and monumental catalogue of the Spain of the time so far had not been properly valued. This chapter describes the col...

  20. El doble subjetivo y el enigma de la locura criminal en / Babel-ville / de Joseph Bialot

    Directory of Open Access Journals (Sweden)

    Ramón García Pradas

    2011-12-01

    Full Text Available Through this article we would like to explore not only the image of the double but also its functions in Bialot’s novel Babel-ville. To do so, we would like to take into account those theoretical studies that Jung, Rank or Jourde and Tortonese (among others have carried out on this subject from a literary and s psychological point of view. We will analyse the main character’s criminal madness as a procedure to generate a double which does not match up with the figure of a human being, as if our main character’s pulsions (his unconscious part were not human at all. So our main purpose in this article will focus on the study of Bernard, the main male character of Bialot’s novel, Babel-ville, which should be considered as a good sample of what literary criticism is inclined to call black novel. That’s why we will try to see how Babel-ville sticks to the main characteristics of these literary manifestations, which, by the way, seem to appear really suitable when an author tries to look into the enigmatic mystery of the double-being in literature.

  1. The Scandinavian Mission of the Sisters of Saint Joseph : A female Counter-Culture in Nordic Society

    OpenAIRE

    Werner, Yvonne Maria

    2014-01-01

    It is well known that Catholic nuns and sisters played an important role in modern society, and that they in many ways paved the way for the entrance of women into professional life within the social sector. Modern research has also pointed out their social achievements as missionaries in the third word. But it is less known that female Catholic congregations also led school, hospitals and other social institutions in Protestant countries in northern Europe. These religious institutes accompa...

  2. Jean Joseph Emile Létiévant: a review of his contributions to surgery and rehabilitation.

    Science.gov (United States)

    Spicher, C; Kohut, G

    2001-04-01

    The life, education, and contributions of E. Létiévant are reviewed. He first observed esthesiography, protopathic sensibility, and the "tingling sign" in peripheral-nerve lesions toward the end of the 19th century. His thoughts and language still remain familiar to us, and his work conveys a poignant freshness.

  3. MOOCs and Joseph Lancaster: Lessons from a Two-Hundred Year Precedent in Mass Learning on a Global Scale

    Science.gov (United States)

    Stevenson, William R., III

    2015-01-01

    Over the past three years, Massive Open Online Courses, or MOOCs, have spanned the globe, educating millions with the potential to reach millions more. Taught by leading academics from top institutions, the courses are as complete as those offered in traditional settings; yet, in being web-based and tuition free, they disregard long-standing…

  4. European Court of Human Rights : case of S. v Estonia, 4 October 2001, no. 17779/08 / Joseph Dute

    Index Scriptorium Estoniae

    Dute, Joseph

    2012-01-01

    Euroopa Inimõiguste Kohtu lahendist 17779/08, milles leiti, et Eesti on isiku kinnisesse asutusse paigutamise menetluses rikkunud Euroopa inimõiguste ja põhivabaduste kaitse konventsiooni artikli 5 lõiget 1

  5. Joseph Barboza de Saa: autor de um manuscrito do seculo XVIII sobre os produtos naturais do Brasil.

    OpenAIRE

    Teixeira, Dante Martins; Papavero, Nelson

    2001-01-01

    Um manuscrito com'63 fólíos (126 páginas), sem indicação de autor, foi achado pelos autores deste artigo na Fundação Biblioteca Nacional, Rio de Janeiro, e por eles publicado em 1999. O manuscrito é dividido em 10 capítulos (não numerados), descrevendo flores, fru­tas, substâncias aromáticas, minerais e metais, pedras preciosas, ani­mais quadrúpedes, répteis e anfíbios, insetos, aves, peixes, e árvores das Capitanias do Rio de Janeiro, São Paulo, Goiás e Mato Grosso, ...

  6. 75 FR 76052 - Southern Nuclear Operating Company, Inc. Joseph M. Farley Nuclear Plant, Units 1 and 2; Exemption

    Science.gov (United States)

    2010-12-07

    ..., Units 1 and 2 (FNP). The licenses provide, among other things, that the facility is subject to all rules... the Commission as discussed in the June 4, 2009, letter. FNP Schedule Exemption Request The licensee... the FNP, as issued on March 27, 2009. 4.0 Conclusion for Part 73 Schedule Exemption Request The NRC...

  7. THE FIRST BOOK PRESENTING ROMANIAN SOCIOLOGY IN THE AMERICAN SCHOLARLY LITERATURE – ROBERT JOSEPH KERNER’S BOOK OF 1930

    Directory of Open Access Journals (Sweden)

    MIHAIL M. CERNEA

    2016-11-01

    Full Text Available This study examines one highly significant event in the history of Romania’s sociology that until now has been largely unknown publicly for an astonishing long period: almost nine decades. The “hero” at the center of that event is the important academic book published in the USA in April 1930 by the American historian Robert J. Kerner, about the Social Sciences in the Balkans and in Turkey, based on Kerner’s visits to Romania, Yugoslavia, Bulgaria, Greece, and Turkey. The book contains a detailed, documented first hand, highly informative and robustly analytical chapter on the ‘state of the art’ in Romania’s sociology in 1928–1929. Cernea describes the serendipitous circumstances in which he discovered the book in 1979, – and realized that Kerner’s book contained the first and earliest presentation of Romania’s sociology in the USA. This discovery corrects the widespread but erroneous attribution of priority in this respect to Philip E. Mosley’s 1935 visit as a young American student to Romania. The study presents Kerner’s professional personality as an internationally recognized scholar, and informs that, at Nicolae Iorga’s recommendation, Kerner was elected in 1938 as corresponding Member of the Academia Română (Romanian Academy. Cernea synthesizes Kerner’s importance for the history of Romania’s sociology in three essential features: a his book is the first comprehensive presentation abroad of Romania’s sociology between WW I and WW II; b the outstanding analytical assessment of its achievements; and c Kerner’s comparative evaluation and ranking of sociology in România, leading to Kerner’s overall conclusion that “in România sociology is better developed than anywhere else in the Balkans”

  8. Bilan de fonctionnement des bassins versants expérimentaux : Les Gohards, Rezé, St-Joseph

    OpenAIRE

    FASQUEL, Marc; FLAHAUT, Bernard; MOSINI, ML; LABORATOIRE CENTRAL DES PONTS ET CHAUSSEES - LCPC

    2002-01-01

    La compréhension et la modélisation du comportement hydrologique du milieu urbain s'appuie sur l'analyse de données hydrologiques robustes. Ce document analyse le fonctionnement de trois bassins versants urbains expérimentaux. Les bassins versants de l'agglomération nantaise et les capteurs installés (pluviomètre et mesure de débit à l'exutoire par un capteur Doppler) sont présentés, et les principales données hydrologiques sont comparées et analysées. Une synthèse des périodes de dysfonction...

  9. 77 FR 49835 - Order Prohibiting Involvement in NRC-Licensed Activities; In the Matter of Mr. Joseph Quintanilla

    Science.gov (United States)

    2012-08-17

    ... operations without wearing his film badge, but he claimed that he was wearing his pocket ion chamber and.... Quintanilla indicated that he was aware the camera was outside of the dark room and did not contest that...

  10. Aerial energetic residue data from JBER C4 testing

    Data.gov (United States)

    U.S. Environmental Protection Agency — Aerially-collected energetic residues from surface detonation of C4. This dataset is associated with the following publication: Walsh, M., B. Gullett, M. Walsh, M....

  11. 48 CFR 1322.604-2 - Regulatory exemptions.

    Science.gov (United States)

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Walsh-Healey Public Contracts Act... a contract or class of contracts from Walsh-Healey Act stipulations is set forth in CAM 1301.70. ...

  12. 77 FR 14361 - Pesticide Products; Receipt of Applications To Register New Uses

    Science.gov (United States)

    2012-03-09

    ... Avenue NW., Washington, DC 20460- 0001, or Biopesticides and Pollution Prevention Division (7511P... commodities. Contact: Colin G. Walsh, Biopesticides and Pollution Prevention Division, (703) 308-0298, walsh... sprouting root, tuber, and bulb crops. Contact: Colin G. Walsh, Biopesticides and Pollution Prevention...

  13. Caída libre. El libre mercado y el hundimiento de la economía global mundial : Joseph Stiglitz, Ed. Taurus, 2010

    OpenAIRE

    Morgante, Martín Adolfo

    2010-01-01

    En este libro se ocupa de la actual –crisis financiera internacional y sus repercusiones en la economía mundial. En realidad la crisis comenzó en el primer mundo-EE.UU, con la crisis de las hipotecas –suprime- o tóxicas que hicieron colapsar a los grandes bancos de inversión y comerciales, como así también a instituciones poderosas y con un gran prestigio como Fanny Mae y Freddie Mac.Esta crisis se originó por la excesiva desregulación financiera durante la década de los noventa- atribuida a ...

  14. A teoria analítica do calor de Joseph Fourier: uma análise das bases conceituais e epistemológicas

    OpenAIRE

    Pifer,Anderson; Aurani,Katya Margareth

    2015-01-01

    Em um ambiente marcado pelo paradigma newtoniano, Fourier estabeleceu sua teoria da propagação do calor em corpos sólidos mantendo a mesma tradição da mecânica racional, a qual reduzia os fenômenos naturais à análise matemática. Contudo, ele rompeu com a abordagem tradicional ao ignorar as hipóteses sobre a natureza do calor e criar um modelo físico no qual as leis da mecânica não se aplicam aos fenômenos do calor. Os ...

  15. Population Dynamics and Conservation Implications of Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter., a Steno Endemic Species of Western Ghats, India.

    Science.gov (United States)

    Mishra, Priyanka; Kumar, L Dinesh; Kumar, Amit; Gokul, Sivaraman; Ravikumar, Kaliamoorthy; Shukla, Ashutosh K; Sundaresan, Velusamy

    2015-07-01

    Decalepis arayalpathra, a critically endangered plant species, has a restricted and fragmented population in Southern Western Ghats, India. This study is a first attempt to evaluate genetic diversity and population structure in the nine wild populations of D. arayalpathra based on molecular pattern realized through the marker assays. Principal coordinate analysis (PCoA) and Nei's unweighted pair-group method with arithmetic average (UPGMA)-based hierarchical clustering of both the marker assays suggest strong genetic clustering between the individuals corresponding to their geographical ranges. Mantel test also corroborates a close genetic proximity between genetic and geographic data (r = 0.389). Population genetic analysis revealed low levels of gene flow [inter-simple sequence repeat (ISSR) = 0.289 and random amplified polymorphic DNA (RAPD) = 0.847] between the populations, in line with high genetic differentiation (Gst = 0.531 with ISSR and 0.440 with RAPD), which was also supported by analysis of molecular variance (AMOVA), that 54 % (ISSR) and 64 % (RAPD) total variation resided within populations. Bayesian model-based STRUCTURE analysis detected three genetic clusters showing the high degree of admixture within population. Based on the findings, such as inbreeding depression and the loss of genetic diversity, suggestions for conservation strategies are provided to preserve the genetic resources of this endangered species.

  16. Joseph F. Keithley Award For Advances in Measurement Science Lecture: Thermophotonic and Photoacoustic Radar Imaging Methods for Biomedical and Dental Imaging

    Science.gov (United States)

    Mandelis, Andreas

    2012-02-01

    In the first part of this presentation I will introduce thermophotonic radar imaging principles and techniques using chirped or binary-phase-coded modulation, methods which can break through the maximum detection depth/depth resolution limitations of conventional photothermal waves. Using matched-filter principles, a methodology enabling parabolic diffusion-wave energy fields to exhibit energy localization akin to propagating hyperbolic wave-fields has been developed. It allows for deconvolution of individual responses of superposed axially discrete sources, opening a new field: depth-resolved thermal coherence tomography. Several examples from dental enamel caries diagnostic imaging to metal subsurface defect thermographic imaging will be discussed. The second part will introduce the field of photoacoustic radar (or sonar) biomedical imaging. I will report the development of a novel biomedical imaging system that utilizes a continuous-wave laser source with a custom intensity modulation pattern, ultrasonic phased array for signal detection and processing coupled with a beamforming algorithm for reconstruction of photoacoustic correlation images. Utilization of specific chirped modulation waveforms (``waveform engineering'') achieves dramatic signal-to-noise-ratio increase and improved axial resolution over pulsed laser photoacoustics. The talk will conclude with aspects of instrumental sensitivity of the PA Radar to optical contrast using cancerous breast tissue-mimicking phantoms, super paramagnetic iron oxide nanoparticles as contrast enhancement agents and in-vivo tissue samples.

  17. Franklin Roosevelt, Pius XII, Joseph Stalin and the Problem of the USSR’s Image and Reputation During the Second World War

    Directory of Open Access Journals (Sweden)

    Filippov Boris

    2016-08-01

    Full Text Available The aggression of Hitler’s Germany against the USSR made our country an ally of the United States and Great Britain. But the decision to help USSR with weapons and hardware (the lend-lease act faced opposition not only from the American isolationists but also from religious groups. Both Catholics and Protestants were against the very idea of helping the country in which churches were destroyed and the faithful were persecuted. They have considered such an idea to be immoral. To overcome the opposition in Congress, president F. D. Roosevelt and the US diplomats tried to convince Stalin to reject his policies of religious oppression. Roosevelt also asked pope Plus XII for help. At the same time German and Italian ambassadors were trying to convince the Pope to support their “crusade against the godless Bolshevik Russia”. The question of USSR’s image was an important issue throughout the course of war. The article tells the history of the most signifi cant efforts undertaken by the Western allies and Stalin to improve the international reputation of the USSR. First of all, it tells the story of the mysterious letter from Stalin to Plus XII (1942 and about even more mysterious visit of the American priest Stanislav Orlemansky to Moscow and his meeting with Stalin in 1944.

  18. Joseph E. Suzanne, Fertile Bonds. Bedouin class, kinship and gender in the Bekaa Valley, University Press of Florida, 2013, 233 p.

    Directory of Open Access Journals (Sweden)

    Mauro Van Aken

    2014-09-01

    Full Text Available The importance of kinship ties and their idiom in marginalized communities in the Middle East and elsewhere is a focal theme in anthropological literature. Reinventing bonds and their symbolical and material meaning in everyday life has been historically one of the main neglected issues in understanding poverty, local coping strategies, class formation and policy making. This is even more true of pastoral communities, which tend to be relegated in social studies to the “traditional” conservat...

  19. Investigation of the radiological safety concerns and medical history of the late Joseph T. Harding, former employee of the Paducah Gaseous Diffusion Plant

    Energy Technology Data Exchange (ETDEWEB)

    Vallario, E.J.; Wolfe, H.R.

    1981-03-01

    An ex-employee's claims that inadequate enforcement of radiation safety regulations allowed excess radiation exposure thereby causing his deteriorating health was not substantiated by a thorough investigation.

  20. Conserved domains and lack of evidence for polyglutamine length polymorphism in the chicken homolog of the Machado-Joseph disease gene product ataxin-3 1

    Czech Academy of Sciences Publication Activity Database

    Linhartová, Irena; Repitz, M.; Dráber, Pavel; Němec, M.; Wiche, G.; Propst, F.

    1999-01-01

    Roč. 1444, č. 2 (1999), s. 299-305 ISSN 0006-3002 R&D Projects: GA AV ČR IAA5052701; GA AV ČR IPP2020702 Institutional research plan: CEZ:AV0Z5052915 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.590, year: 1999