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Sample records for confirmed tumefactive multiple

  1. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis

    Science.gov (United States)

    Gavrilova, R. H.; Metz, I.; Parisi, J. E.; Scheithauer, B. W.; Weigand, S.; Thomsen, K.; Mandrekar, J.; Altintas, A.; Erickson, B. J.; König, F.; Giannini, C.; Lassmann, H.; Linbo, L.; Pittock, S. J.; Brück, W.

    2008-01-01

    Atypical imaging features of multiple sclerosis lesions include size >2 cm, mass effect, oedema and/or ring enhancement. This constellation is often referred to as ‘tumefactive multiple sclerosis’. Previous series emphasize their unifocal and clinically isolated nature, however, evolution of these lesions is not well defined. Biopsy may be required for diagnosis. We describe clinical and radiographic features in 168 patients with biopsy confirmed CNS inflammatory demyelinating disease (IDD). Lesions were analysed on pre- and post-biopsy magnetic resonance imaging (MRI) for location, size, mass effect/oedema, enhancement, multifocality and fulfilment of Barkhof criteria. Clinical data were correlated to MRI. Female to male ratio was 1.2 : 1, median age at onset, 37 years, duration between symptom onset and biopsy, 7.1 weeks and total disease duration, 3.9 years. Clinical course prior to biopsy was a first neurological event in 61%, relapsing–remitting in 29% and progressive in 4%. Presentations were typically polysymptomatic, with motor, cognitive and sensory symptoms predominating. Aphasia, agnosia, seizures and visual field defects were observed. At follow-up, 70% developed definite multiple sclerosis, and 14% had an isolated demyelinating syndrome. Median time to second attack was 4.8 years, and median EDSS at follow-up was 3.0. Multiple lesions were present in 70% on pre-biopsy MRI, and in 83% by last MRI, with Barkhof criteria fulfilled in 46% prior to biopsy and 55% by follow-up. Only 17% of cases remained unifocal. Median largest lesion size on T2-weighted images was 4 cm (range 0.5–12), with a discernible size of 2.1 cm (range 0.5–7.5). Biopsied lesions demonstrated mass effect in 45% and oedema in 77%. A strong association was found between lesion size, and presence of mass effect and/or oedema (P 5 cm was associated with a slightly higher EDSS at last follow-up, long-term prognosis in patients with disease duration >10 years was better (EDSS 1

  2. A tumefactive multiple sclerosis lesion in the brain: An uncommon site with atypical magnetic resonance image findings

    International Nuclear Information System (INIS)

    Jeong, Min Sun; Kim, Hyun Sook; Kim, Jae Hoon; Kim, Eun Kyung; Choi, Yun Sun

    2013-01-01

    Tumefactive multiple sclerosis (MS) is a rare type of demyelinating disease. Typical magnetic resonance (MR) image findings show incomplete ring enhancement with a mild mass effect. This lesion is otherwise indistinguishable from other mass-like lesions in the brain. Knowledge of the MR imaging findings for tumefactive MS is thus helpful for correct diagnosis and appropriate therapy. In this report we describe the MR image findings for pathology-confirmed tumefactive MS in an uncommon location, alongside a discussion of its aggressive features.

  3. A tumefactive multiple sclerosis lesion in the brain: An uncommon site with atypical magnetic resonance image findings

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Min Sun; Kim, Hyun Sook; Kim, Jae Hoon; Kim, Eun Kyung; Choi, Yun Sun [Eulji Hospital, Eulji University, Seoul (Korea, Republic of)

    2013-11-15

    Tumefactive multiple sclerosis (MS) is a rare type of demyelinating disease. Typical magnetic resonance (MR) image findings show incomplete ring enhancement with a mild mass effect. This lesion is otherwise indistinguishable from other mass-like lesions in the brain. Knowledge of the MR imaging findings for tumefactive MS is thus helpful for correct diagnosis and appropriate therapy. In this report we describe the MR image findings for pathology-confirmed tumefactive MS in an uncommon location, alongside a discussion of its aggressive features.

  4. Tumefactive demyelinating lesions

    International Nuclear Information System (INIS)

    Dagher, A.P.; Smirniotopoulos, J.; Armed Forces Inst. of Pathology, Washington, DC

    1996-01-01

    We studied 21 cases of pathologically confirmed tumefactive demyelinating lesions and reviewed the spectrum of tumefactive demyelinating lesions in the literature. Radiological features and clinical data were reviewed to characterize the lesions as consistent with a known demyelinating disease, most notably multiple sclerosis. Atypical clinical or radiological features (other than tumefaction) were noted. Most lesions were part of a clinical and/or radiological picture consistent with multiple sclerosis. No case strongly suggestive of variants or related diseases, such as Schilder's disease or Balo's concentric sclerosis, were found. There was one case suggestive of acute disseminated encephalomyelitis. Features which help distinguish the lesions from tumour are discussed. (orig.)

  5. Tumefactive demyelinating lesions

    Energy Technology Data Exchange (ETDEWEB)

    Dagher, A.P. [Thomas Jefferson Univ. Hospital, Philadelphia, PA (United States). Div. of Neuroradiology; Smirniotopoulos, J. [Thomas Jefferson Univ. Hospital, Philadelphia, PA (United States). Div. of Neuroradiology]|[Armed Forces Inst. of Pathology, Washington, DC (United States). Dept. of Radiological Pathology

    1996-08-01

    We studied 21 cases of pathologically confirmed tumefactive demyelinating lesions and reviewed the spectrum of tumefactive demyelinating lesions in the literature. Radiological features and clinical data were reviewed to characterize the lesions as consistent with a known demyelinating disease, most notably multiple sclerosis. Atypical clinical or radiological features (other than tumefaction) were noted. Most lesions were part of a clinical and/or radiological picture consistent with multiple sclerosis. No case strongly suggestive of variants or related diseases, such as Schilder`s disease or Balo`s concentric sclerosis, were found. There was one case suggestive of acute disseminated encephalomyelitis. Features which help distinguish the lesions from tumour are discussed. (orig.)

  6. Primary CNS Lymphoma vs. Tumefactive Multiple Sclerosis: A Diagnostic Challenge.

    Science.gov (United States)

    Naeem, Sameen Bin; Niazi, Farheen; Baig, Atif; Sadiq, Hina; Sattar, Mubbasher

    2018-01-01

    Primary CNS (central nervous system) lymphoma is a rare condition with the incidence of less than 1% of all non-Hodgkin lymphomas (NHLs) and approximately 2% of all primary brain tumours. Diagnosis can be challenging and necessitates brain biopsy for definitive diagnosis. A 41-year male presented with history of impaired cognition, facial asymmetry, visual impairment and left sided body weakness. MRI brain demonstrated multiple enhancing lesions with one larger lesion in right basal ganglia with surrounding oedema and mass effect. These findings suggested the differential diagnoses of tumefactive multiple sclerosis (MS), primary CNS lymphoma (PCNSL) and tuberculosis. The patient had normal CT chest, abdomen and pelvis, normal CSF examination and cytology, negative CSF oligoclonal bands (OCBs) and negative HIV screening. It was impossible to differentiate between tumefactive MS and PCNSL without undertaking brain biopsy. Diffuse large B cell lymphoma (DLBCL) was the final diagnosis. Diagnosing PCNSL can be challenging and brain biopsy should not be delayed for definitive diagnosis and targeted treatment.

  7. Tumefactive multiple sclerosis requiring emergency craniotomy: case report and literature review.

    Science.gov (United States)

    Munarriz, Pablo M; Castaño-Leon, Ana M; Martinez-Perez, Rafael; Hernandez-Lain, Aurelio; Ramos, Ana; Lagares, Alfonso

    2013-01-01

    Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by focal neurological dysfunction with a relapsing and remitting course. Tumor-like presentation of MS (or "tumefactive"/"pseudotumoral" presentation) has been described before with a certain frequency; it consists of a large single plaque (>2cm) with presence of edema and mass effect and it is hard to distinguish from a brain tumor. However, we present a very rare case of a 53-year-old woman with a right temporal mass that turned out to be a MS plaque, who deteriorated within hours (brain herniation with loss of consciousness and unilateral mydriasis) and required an emergency craniotomy. We also present a review of the literature. It appears that only 4 cases of emergency craniotomy/craniectomy required in a patient with a tumor-like MS plaque have been reported before. Copyright © 2012 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  8. Tumefactive intracranial presentation of precursor B-cell acute lymphoblastic leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Forester, Craig M. [University of Utah, Salt Lake City, UT (United States); Braunreiter, Chi L. [University of Utah, Division of Pediatric Hematology Oncology, Primary Children' s Medical Center, Salt Lake City, UT (United States); Helen DeVos Children' s Hospital, Department of Pediatric Hematology Oncology, Grand Rapids, MI (United States); Yaish, Hasan; Afify, Zeinab [University of Utah, Division of Pediatric Hematology Oncology, Primary Children' s Medical Center, Salt Lake City, UT (United States); Hedlund, Gary L. [Primary Children' s Medical Center, Department of Pediatric Radiology, Salt Lake City, UT (United States)

    2009-11-15

    In children, leukemia is the most common malignancy, and approximately 75% of leukemias are acute lymphoblastic leukemia (ALL). Central nervous system leukemia is found at diagnosis in fewer than 5% of children with ALL. Leukemic intracranial masses have been described with acute myeloid leukemia, but ALL presenting as a mass lesion is rare. We describe a unique case of an intracranial confirmed precursor B cell (pre-B) ALL mass in a 13-year-old girl that was diagnosed by brain CT, MRI and cerebral angiography, and confirmed by biopsy. This report details pertinent history and distinguishing imaging features of an intracranial ALL tumefaction. (orig.)

  9. Tumefactive intracranial presentation of precursor B-cell acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    Forester, Craig M.; Braunreiter, Chi L.; Yaish, Hasan; Afify, Zeinab; Hedlund, Gary L.

    2009-01-01

    In children, leukemia is the most common malignancy, and approximately 75% of leukemias are acute lymphoblastic leukemia (ALL). Central nervous system leukemia is found at diagnosis in fewer than 5% of children with ALL. Leukemic intracranial masses have been described with acute myeloid leukemia, but ALL presenting as a mass lesion is rare. We describe a unique case of an intracranial confirmed precursor B cell (pre-B) ALL mass in a 13-year-old girl that was diagnosed by brain CT, MRI and cerebral angiography, and confirmed by biopsy. This report details pertinent history and distinguishing imaging features of an intracranial ALL tumefaction. (orig.)

  10. Conventional MRI and magnetisation transfer imaging of tumour-like multiple sclerosis in a child

    International Nuclear Information System (INIS)

    Metafratzi, Z.; Argyropoulou, M.I.; Efremidis, S.C.; Tzoufi, M.; Papadopoulou, Z.

    2002-01-01

    Tumefactive multiple sclerosis is a rare entity in children. Differential diagnosis includes other mass lesions such as neoplasm and abscess. A case of tumefactive multiple sclerosis in a child is presented. The open-ring pattern of enhancement on conventional MRI and magnetisation transfer imaging was important for the initial diagnosis and the evaluation of the course of the disease. (orig.)

  11. Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy

    NARCIS (Netherlands)

    Massey, L.A.; Micallef, C.; Paviour, D.C.; O'Sullivan, S.S.; Ling, H.; Williams, D.R.; Kallis, C.; Holton, J.L.; Revesz, T.; Burn, D.J.; Yousry, T.; Lees, A.J.; Fox, N.C.; Jäger, H.R.

    2012-01-01

    Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), but its ability to predict the histopathological diagnosis has not been systematically studied. cMRI from 48 neuropathologically confirmed

  12. Tumefactive lipedema with pseudoxanthoma elasticum-like microscopic changes.

    Science.gov (United States)

    Taylor, Nancy E; Foster, William C; Wick, Mark R; Patterson, James W

    2004-02-01

    Lipedema is a condition characterized by diffuse, bilaterally symmetrical, painful swelling of the legs and buttocks. Microscopically, there are dermal and septal edema, adipocyte degeneration, and numerous mast cells, features held in common with lipedematous alopecia. We present the case of a 60-year-old woman with a long history of bilateral leg masses with microscopic features of lipedema. In addition, elastic-fiber changes typical of pseudoxanthoma elasticum (PXE) were discovered within the subcutaneous septa in three separate specimens obtained from an affected extremity. The patient did not have other clinical findings of PXE, although there was a history of both hypertension and congestive heart failure. This tumefactive presentation of lipedema has not been previously described. Regarding the elastic-tissue abnormalities, the patient could have either a subclinical form of PXE, perhaps predisposing to lipedema, or secondary elastic-tissue changes resulting from the massive edema. If the latter is the case, then this could represent an unusual manifestation of localized acquired cutaneous PXE (calcific elastosis).

  13. Tumefactive appearance of peripheral nerve involvement in hematologic malignancies: a new imaging association

    Energy Technology Data Exchange (ETDEWEB)

    Capek, Stepan [Mayo Clinic, Department of Neurosurgery, Rochester, Minnesota (United States); St. Anne' s University Hospital Brno, International Clinical Research Center, Brno (Czech Republic); Hebert-Blouin, Marie-Noelle [McGill University, Department of Neurologic Surgery, Montreal, Quebec (Canada); Puffer, Ross C.; Spinner, Robert J. [Mayo Clinic, Department of Neurosurgery, Rochester, Minnesota (United States); Martinoli, Carlo [Universita degli Studi di Genova, Department of Radiology, Genova (Italy); Frick, Matthew A.; Amrami, Kimberly K. [Mayo Clinic, Department of Radiology, Rochester, MN (United States)

    2015-04-29

    In neurolymphomatosis (NL), the affected nerves are typically described to be enlarged and hyperintense on T2W MR sequences and to avidly enhance on gadolinium-enhanced T1WI. This pattern is highly non-specific. We recently became aware of a ''tumefactive pattern'' of NL, neuroleukemiosis (NLK) and neuroplasmacytoma (NPLC), which we believe is exclusive to hematologic diseases affecting peripheral nerves. We defined a ''tumefactive'' appearance as complex, fusiform, hyperintense on T2WI, circumferential tumor masses encasing the involved peripheral nerves. The nerves appear to be infiltrated by the tumor. Both structures show varying levels of homogenous enhancement. We reviewed our series of 52 cases of NL in search of this pattern; two extra outside cases of NL, three cases of NLK, and one case of NPLC were added to the series. We identified 20 tumefactive lesions in 18 patients (14 NL, three NLK, one NPLC). The brachial plexus (n = 7) was most commonly affected, followed by the sciatic nerve (n = 6) and lumbosacral plexus (n = 3). Four patients had involvement of other nerves. All were proven by biopsy: the diagnosis was high-grade lymphoma (n = 12), low-grade lymphoma (n = 3), acute leukemia (n = 2), and plasmacytoma (n = 1). We present a new imaging pattern of ''tumefactive'' neurolymphomatosis, neuroleukemiosis, or neuroplasmacytoma in a series of 18 cases. We believe this pattern is associated with hematologic diseases directly involving the peripheral nerves. Knowledge of this association can provide a clue to clinicians in establishing the correct diagnosis. Bearing in mind that tumefactive NL, NLK, and NPLC is a newly introduced imaging pattern, we still recommend to biopsy patients with suspicion of a malignancy. (orig.)

  14. Relapsing and Progressive Tumefactive Demyelinating Form of Central Nervous System Involvement in a Patient with Progressive Systemic Sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ho Kyun [Dept. of Radiology, Catholic University of Daegu School of Medicine, Daegu (Korea, Republic of); Lee, Hui Joong [Dept. of Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2013-03-15

    White matter hyper intensities (WMHI) on MRI are not rare in patients with progressive systemic sclerosis (PSS). In this presentation, WMHI were developed in both middle cerebellar peduncles and temporal white matter in a patient with PSS, and regressed after medication of high dose steroid. However, new lesions were developed in the subcortices of both precentral gyri, and progressed rapidly to tumefactive hyperintensity on MRI. We report an unusual relapsing and progressive tumefactive demyelinating form of central nervous system involvement in PSS.

  15. Relapsing and Progressive Tumefactive Demyelinating Form of Central Nervous System Involvement in a Patient with Progressive Systemic Sclerosis

    International Nuclear Information System (INIS)

    Kim, Ho Kyun; Lee, Hui Joong

    2013-01-01

    White matter hyper intensities (WMHI) on MRI are not rare in patients with progressive systemic sclerosis (PSS). In this presentation, WMHI were developed in both middle cerebellar peduncles and temporal white matter in a patient with PSS, and regressed after medication of high dose steroid. However, new lesions were developed in the subcortices of both precentral gyri, and progressed rapidly to tumefactive hyperintensity on MRI. We report an unusual relapsing and progressive tumefactive demyelinating form of central nervous system involvement in PSS.

  16. Multiple Novel Prostate Cancer Predisposition Loci Confirmed by an International Study: The PRACTICAL Consortium

    Science.gov (United States)

    Kote-Jarai, Zsofia; Easton, Douglas F.; Stanford, Janet L.; Ostrander, Elaine A.; Schleutker, Johanna; Ingles, Sue A.; Schaid, Daniel; Thibodeau, Stephen; Dörk, Thilo; Neal, David; Cox, Angela; Maier, Christiane; Vogel, Walter; Guy, Michelle; Muir, Kenneth; Lophatananon, Artitaya; Kedda, Mary-Anne; Spurdle, Amanda; Steginga, Suzanne; John, Esther M.; Giles, Graham; Hopper, John; Chappuis, Pierre O.; Hutter, Pierre; Foulkes, William D.; Hamel, Nancy; Salinas, Claudia A.; Koopmeiners, Joseph S.; Karyadi, Danielle M.; Johanneson, Bo; Wahlfors, Tiina; Tammela, Teuvo L.; Stern, Mariana C.; Corral, Roman; McDonnell, Shannon K.; Schürmann, Peter; Meyer, Andreas; Kuefer, Rainer; Leongamornlert, Daniel A.; Tymrakiewicz, Malgorzata; Liu, Jo-fen; O'Mara, Tracy; Gardiner, R.A. (Frank); Aitken, Joanne; Joshi, Amit D.; Severi, Gianluca; English, Dallas R.; Southey, Melissa; Edwards, Stephen M.; Amin Al Olama, Ali; Eeles, Rosalind A.

    2009-01-01

    A recent genome-wide association study found that genetic variants on chromosomes 3, 6, 7, 10, 11, 19 and X were associated with prostate cancer risk. We evaluated the most significant single-nucleotide polymorphisms (SNP) in these loci using a worldwide consortium of 13 groups (PRACTICAL). Blood DNA from 7,370 prostate cancer cases and 5,742 male controls was analyzed by genotyping assays. Odds ratios (OR) associated with each genotype were estimated using unconditional logistic regression. Six of the seven SNPs showed clear evidence of association with prostate cancer (P = 0.0007-P = 10−17). For each of these six SNPs, the estimated per-allele OR was similar to those previously reported and ranged from 1.12 to 1.29. One SNP on 3p12 (rs2660753) showed a weaker association than previously reported [per-allele OR, 1.08 (95% confidence interval, 1.00-1.16; P = 0.06) versus 1.18 (95% confidence interval, 1.06-1.31)]. The combined risks associated with each pair of SNPs were consistent with a multiplicative risk model. Under this model, and in combination with previously reported SNPs on 8q and 17q, these loci explain 16% of the familial risk of the disease, and men in the top 10% of the risk distribution have a 2.1-fold increased risk relative to general population rates. This study provides strong confirmation of these susceptibility loci in multiple populations and shows that they make an important contribution to prostate cancer risk prediction. PMID:18708398

  17. Transit Timing Observations from Kepler: IV. Confirmation of 4 Multiple Planet Systems by Simple Physical Models

    Energy Technology Data Exchange (ETDEWEB)

    Fabrycky, Daniel C.; /UC, Santa Cruz; Ford, Eric B.; /Florida U.; Steffen, Jason H.; /Fermilab; Rowe, Jason F.; /SETI Inst., Mtn. View /NASA, Ames; Carter, Joshua A.; /Harvard-Smithsonian Ctr. Astrophys.; Moorhead, Althea V.; /Florida U.; Batalha, Natalie M.; /San Jose State U.; Borucki, William J.; /NASA, Ames; Bryson, Steve; /NASA, Ames; Buchhave, Lars A.; /Bohr Inst. /Copenhagen U.; Christiansen, Jessie L.; /SETI Inst., Mtn. View /NASA, Ames /Caltech

    2012-01-01

    Eighty planetary systems of two or more planets are known to orbit stars other than the Sun. For most, the data can be sufficiently explained by non-interacting Keplerian orbits, so the dynamical interactions of these systems have not been observed. Here we present 4 sets of lightcurves from the Kepler spacecraft, which each show multiple planets transiting the same star. Departure of the timing of these transits from strict periodicity indicates the planets are perturbing each other: the observed timing variations match the forcing frequency of the other planet. This confirms that these objects are in the same system. Next we limit their masses to the planetary regime by requiring the system remain stable for astronomical timescales. Finally, we report dynamical fits to the transit times, yielding possible values for the planets masses and eccentricities. As the timespan of timing data increases, dynamical fits may allow detailed constraints on the systems architectures, even in cases for which high-precision Doppler follow-up is impractical.

  18. A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis

    DEFF Research Database (Denmark)

    Mero, Inger-Lise; Lorentzen, Aslaug R; Ban, Maria

    2010-01-01

    A rare functional variant within the TYK2 gene (rs34536443) has been reported as protective in multiple sclerosis (MS) in recent studies. However, because of the low frequency of the minor allele (minor allele frequency=0.04), genome-wide significant association has been hard to establish. We gen...

  19. Tumefactive immunoglobulin G4-related disease involving the dura mater: A case report and literature review

    International Nuclear Information System (INIS)

    Lee, Jeong Hoon; Lee, Ji Hoon; Ko, Yong; Paik, Seoung Sam; Lee, Young Jun; Park, Dong Woo

    2015-01-01

    Immunoglobulin G4 (IgG4)-related disease is a well-known disorder characterized by an inflammatory reaction with an increase in the number of IgG4-positive plasma cells associated with sclerosis. IgG4-related disease often affects the dura mater with a pattern of diffuse thickening when the central nervous system is involved. However, some nodular dural thickening requires discrimination from tumors because of obviously different treatment options. We report of a case of IgG4-related disease with tumefactive dural involvement

  20. Tumefactive immunoglobulin G4-related disease involving the dura mater: A case report and literature review

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Hoon; Lee, Ji Hoon; Ko, Yong; Paik, Seoung Sam; Lee, Young Jun [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of); Park, Dong Woo [Dept. of Radiology, Hanyang University Hospital, Seoul (Korea, Republic of)

    2015-08-15

    Immunoglobulin G4 (IgG4)-related disease is a well-known disorder characterized by an inflammatory reaction with an increase in the number of IgG4-positive plasma cells associated with sclerosis. IgG4-related disease often affects the dura mater with a pattern of diffuse thickening when the central nervous system is involved. However, some nodular dural thickening requires discrimination from tumors because of obviously different treatment options. We report of a case of IgG4-related disease with tumefactive dural involvement.

  1. Associations between multiple indoor environmental factors and clinically confirmed allergic disease in early childhood

    DEFF Research Database (Denmark)

    Callesen, Mette Buhl; Bekö, Gabriel; Weschler, Charles J.

    2012-01-01

    Background: Previous studies, mainly questionnaires have reported associations between some indoor environmental factors and allergic diseases. Our aim was to investigate the possible association between objectively assessed indoor environmental factors and clinically confirmed asthma......, rhinoconjunctivitis and atopic dermatitis. Method: A crosssectional case-cohort study (n = 500) based on 2835 children, aged 3–5 years, responding to a questionnaire, consisted of 300 subjects randomly selected and 200 cases with at least two parentally reported doctor diagnosed allergic diseases (asthma, allergic.......05) in sensitized children with asthma. Concentrations of nicotine and house dust mite allergens were higher (P environmental factors...

  2. A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis.

    Science.gov (United States)

    Mero, Inger-Lise; Lorentzen, Aslaug R; Ban, Maria; Smestad, Cathrine; Celius, Elisabeth G; Aarseth, Jan H; Myhr, Kjell-Morten; Link, Jenny; Hillert, Jan; Olsson, Tomas; Kockum, Ingrid; Masterman, Thomas; Oturai, Annette Bang; Søndergaard, Helle Bach; Sellebjerg, Finn; Saarela, Janna; Kemppinen, Anu; Elovaara, Irina; Spurkland, Anne; Dudbridge, Frank; Lie, Benedicte A; Harbo, Hanne F

    2010-04-01

    A rare functional variant within the TYK2 gene (rs34536443) has been reported as protective in multiple sclerosis (MS) in recent studies. However, because of the low frequency of the minor allele (minor allele frequency=0.04), genome-wide significant association has been hard to establish. We genotyped 5429 Nordic MS cases and 6167 healthy controls for this TYK2 non-synonymous single-nucleotide polymorphism (ns-SNP), and combined the Nordic genotype data with raw genotypes from previous studies. The combined Nordic analysis showed significant association with MS (P=5 x 10(-4), odds ratio (OR) 0.78), and by mega-analysis of 10 642 MS patients, 10 620 controls and 2110 MS trios, the association at genome-wide significance level (P=5.08 x 10(-9), OR 0.77) was shown.

  3. Multiple sclerosis, from referral to confirmed diagnosis: an audit of clinical practice.

    LENUS (Irish Health Repository)

    Kelly, S B

    2012-02-01

    BACKGROUND: The National Institute for Health and Clinical Excellence (NICE) guidelines recommend a timeline of 6 weeks from referral to neurology consultation and then 6 weeks to a diagnosis of multiple sclerosis (MS). OBJECTIVES: We audited the clinical management of all new outpatient referrals diagnosed with MS between January 2007 and May 2010. METHODS: We analysed the timelines from referral to first clinic visit, to MRI studies and lumbar puncture (LP) (if performed) and the overall interval from first visit to the time the diagnosis was given to the patient. RESULTS: Of the 119 diagnoses of MS\\/Clinically Isolated Syndrome (CIS), 93 (78%) were seen within 6 weeks of referral. MRI was performed before first visit in 61% and within 6 weeks in a further 27%. A lumbar puncture (LP) was performed in 83% of all patients and was done within 6 weeks in 78%. In total, 63 (53%) patients received their final diagnosis within 6 weeks of their first clinic visit, with 57 (48%) patients having their diagnosis delayed. The main rate-limiting steps were the availability of imaging and LP, and administrative issues. CONCLUSIONS: We conclude that, even with careful scheduling, it is difficult for a specialist service to obtain MRI scans and LP results so as to fulfil NICE guidelines within the optimal six-week period. An improved service would require MRI scans to be arranged before the first clinic visit in all patients with suspected MS.

  4. Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1.

    Directory of Open Access Journals (Sweden)

    Fuencisla Matesanz

    Full Text Available Multiple Sclerosis (MS is the most common progressive and disabling neurological condition affecting young adults in the world today. From a genetic point of view, MS is a complex disorder resulting from the combination of genetic and non-genetic factors. We aimed to identify previously unidentified loci conducting a new GWAS of Multiple Sclerosis (MS in a sample of 296 MS cases and 801 controls from the Spanish population. Meta-analysis of our data in combination with previous GWAS was done. A total of 17 GWAS-significant SNPs, corresponding to three different loci were identified:HLA, IL2RA, and 5p13.1. All three have been previously reported as GWAS-significant. We confirmed our observation in 5p13.1 for rs9292777 using two additional independent Spanish samples to make a total of 4912 MS cases and 7498 controls (ORpooled = 0.84; 95%CI: 0.80-0.89; p = 1.36 × 10-9. This SNP differs from the one reported within this locus in a recent GWAS. Although it is unclear whether both signals are tapping the same genetic association, it seems clear that this locus plays an important role in the pathogenesis of MS.

  5. Genome-Wide Association Study of Multiple Sclerosis Confirms a Novel Locus at 5p13.1

    Science.gov (United States)

    Sanna, Serena; Gayán, Javier; Urcelay, Elena; Zara, Ilenia; Pitzalis, Maristella; Cavanillas, María L.; Arroyo, Rafael; Zoledziewska, Magdalena; Marrosu, Marisa; Fernández, Oscar; Leyva, Laura; Alcina, Antonio; Fedetz, Maria; Moreno-Rey, Concha; Velasco, Juan; Real, Luis M.; Ruiz-Peña, Juan Luis; Cucca, Francesco

    2012-01-01

    Multiple Sclerosis (MS) is the most common progressive and disabling neurological condition affecting young adults in the world today. From a genetic point of view, MS is a complex disorder resulting from the combination of genetic and non-genetic factors. We aimed to identify previously unidentified loci conducting a new GWAS of Multiple Sclerosis (MS) in a sample of 296 MS cases and 801 controls from the Spanish population. Meta-analysis of our data in combination with previous GWAS was done. A total of 17 GWAS-significant SNPs, corresponding to three different loci were identified:HLA, IL2RA, and 5p13.1. All three have been previously reported as GWAS-significant. We confirmed our observation in 5p13.1 for rs9292777 using two additional independent Spanish samples to make a total of 4912 MS cases and 7498 controls (ORpooled = 0.84; 95%CI: 0.80–0.89; p = 1.36×10-9). This SNP differs from the one reported within this locus in a recent GWAS. Although it is unclear whether both signals are tapping the same genetic association, it seems clear that this locus plays an important role in the pathogenesis of MS. PMID:22570697

  6. Combining Diffusion Tensor Metrics and DSC Perfusion Imaging: Can It Improve the Diagnostic Accuracy in Differentiating Tumefactive Demyelination from High-Grade Glioma?

    Science.gov (United States)

    Hiremath, S B; Muraleedharan, A; Kumar, S; Nagesh, C; Kesavadas, C; Abraham, M; Kapilamoorthy, T R; Thomas, B

    2017-04-01

    Tumefactive demyelinating lesions with atypical features can mimic high-grade gliomas on conventional imaging sequences. The aim of this study was to assess the role of conventional imaging, DTI metrics ( p:q tensor decomposition), and DSC perfusion in differentiating tumefactive demyelinating lesions and high-grade gliomas. Fourteen patients with tumefactive demyelinating lesions and 21 patients with high-grade gliomas underwent brain MR imaging with conventional, DTI, and DSC perfusion imaging. Imaging sequences were assessed for differentiation of the lesions. DTI metrics in the enhancing areas and perilesional hyperintensity were obtained by ROI analysis, and the relative CBV values in enhancing areas were calculated on DSC perfusion imaging. Conventional imaging sequences had a sensitivity of 80.9% and specificity of 57.1% in differentiating high-grade gliomas ( P = .049) from tumefactive demyelinating lesions. DTI metrics ( p : q tensor decomposition) and DSC perfusion demonstrated a statistically significant difference in the mean values of ADC, the isotropic component of the diffusion tensor, the anisotropic component of the diffusion tensor, the total magnitude of the diffusion tensor, and rCBV among enhancing portions in tumefactive demyelinating lesions and high-grade gliomas ( P ≤ .02), with the highest specificity for ADC, the anisotropic component of the diffusion tensor, and relative CBV (92.9%). Mean fractional anisotropy values showed no significant statistical difference between tumefactive demyelinating lesions and high-grade gliomas. The combination of DTI and DSC parameters improved the diagnostic accuracy (area under the curve = 0.901). Addition of a heterogeneous enhancement pattern to DTI and DSC parameters improved it further (area under the curve = 0.966). The sensitivity increased from 71.4% to 85.7% after the addition of the enhancement pattern. DTI and DSC perfusion add profoundly to conventional imaging in differentiating tumefactive

  7. Progressive tumefactive fibroinflammatory lesion of the infratemporal fossa treated by radiation therapy

    Directory of Open Access Journals (Sweden)

    Brian O’Sullivan

    2012-01-01

    Full Text Available Tumefactive fibroinflammatory lesion (TFIL is a rare benign tumor in the head and neck region. We present a case of a 40-year-old female with a benign but progressive lesion of the infratemporal fossa, which was diagnosed as TFIL. Patient responded briefly to a course of steroid treatment but eventually showed progression and was unresponsive to further steroids. She was then treated with external beam radiation to a dose of 60 Gy in 30 fractions. After radiation a slow, gradual decrease in tumor size was noted over the course of years and she is free of disease after more than 11 years of follow-up. The major longterm side effect this patient developed was an expected unilateral radiation-induced retinopathy, due to the close proximity of the lesion to the orbit. The dilemma of treatment of benign disease with radiation with potential long-term complications is discussed and a review of the literature on TFIL is presented.

  8. Dynamometer-based measure of spasticity confirms limited association between plantarflexor spasticity and walking function in persons with multiple sclerosis

    Science.gov (United States)

    Kremer, Theodore R.; Van Dillen, Linda R.; Wagner, Joanne M.

    2017-01-01

    The literature shows inconsistent evidence regarding the association between clinically assessed plantarflexor (PF) spasticity and walking function in ambulatory persons with multiple sclerosis (pwMS). The use of a dynamometer-based spasticity measure (DSM) may help to clarify this association. Our cohort included 42 pwMS (27 female, 15 male; age: 42.9 +/− 10.2 yr) with mild clinical disability (Expanded Disability Status Scale score: 3.6 +/− 1.6). PF spasticity was assessed using a clinical measure, the modified Ashworth Scale (MAS), and an instrumented measure, the DSM. Walking function was assessed by the timed 25-foot walk test (T25FWT), the 6-minute walk test (6MWT), and the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Spearman rho correlations were used to evaluate relationships between spasticity measures, measures of walking speed and endurance, and self-perceived limitations in walking. The correlation was small between PF spasticity and the T25FWT (PF maximum [Max] MAS rho = 0.27, PF Max DSM rho = 0.26), the 6MWT (PF Max MAS rho = −0.20, PF Max DSM rho = −0.21), and the MSWS-12 (PF Max MAS rho = 0.11, PF Max DSM rho = 0.26). Our results are similar to reports in other neurologic clinical populations, wherein spasticity has a limited association with walking dysfunction. PMID:25356797

  9. Dynamometer-based measure of spasticity confirms limited association between plantarflexor spasticity and walking function in persons with multiple sclerosis.

    Science.gov (United States)

    Kremer, Theodore R; Van Dillen, Linda R; Wagner, Joanne M

    2014-01-01

    The literature shows inconsistent evidence regarding the association between clinically assessed plantar-flexor (PF) spasticity and walking function in ambulatory persons with multiple sclerosis (pwMS). The use of a dynamometer-based spasticity measure (DSM) may help to clarify this association. Our cohort included 42 pwMS (27 female, 15 male; age: 42.9 +/- 10.1 yr) with mild clinical disability (Expanded Disability Status Scale score: 3.6 +/- 1.6). PF spasticity was assessed using a clinical measure, the modified Ashworth Scale (MAS), and an instrumented measure, the DSM. Walking function was assessed by the timed 25-foot walk test (T25FWT), the 6-minute walk test (6MWT), and the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Spearman rho correlations were used to evaluate relationships between spasticity measures, measures of walking speed and endurance, and self-perceived limitations in walking. The correlation was small between PF spasticity and the T25FWT (PF maximum [Max] MAS rho = 0.27, PF Max DSM rho = 0.26), the 6MWT (PF Max MAS rho = -0.20, PF Max DSM rho = -0.21), and the MSWS-12 (PF Max MAS rho = 0.11, PF Max DSM rho = 0.26). Our results are similar to reports in other neurologic clinical populations, wherein spasticity has a limited association with walking dysfunction.

  10. Transit Timing Observations from Kepler: III. Confirmation of 4 Multiple Planet Systems by a Fourier-Domain Study of Anti-correlated Transit Timing Variations

    Energy Technology Data Exchange (ETDEWEB)

    Steffen, Jason H.; /Fermilab; Fabrycky, Daniel C.; /Lick Observ.; Ford, Eric B.; /Florida U.; Carter, Joshua A.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Holman, Matthew J.; /Harvard-Smithsonian Ctr. Astrophys.; Lissauer, Jack J.; /NASA, Ames; Rowe, Jason F.; /SETI Inst., Mtn. View /NASA, Ames; Ragozzine, Darin; /Harvard-Smithsonian Ctr. Astrophys.; Welsh, William F.; /Caltech; Borucki, William J.; /NASA, Ames /UC, Santa Barbara

    2012-01-01

    We present a method to confirm the planetary nature of objects in systems with multiple transiting exoplanet candidates. This method involves a Fourier-domain analysis of the deviations in the transit times from a constant period that result from dynamical interactions within the system. The combination of observed anticorrelations in the transit times and mass constraints from dynamical stability allow us to claim the discovery of four planetary systems, Kepler-25, Kepler-26, Kepler-27 and Kepler-28, containing eight planets and one additional planet candidate.

  11. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the CONFIRM study.

    LENUS (Irish Health Repository)

    Hutchinson, Michael

    2013-09-01

    In the phase 3, randomized, placebo-controlled and active reference (glatiramer acetate) comparator CONFIRM study in patients with relapsing-remitting multiple sclerosis, oral BG-12 (dimethyl fumarate) reduced the annualized relapse rate (ARR; primary endpoint), as well as the proportion of patients relapsed, magnetic resonance imaging lesion activity, and confirmed disability progression, compared with placebo. We investigated the clinical efficacy of BG-12 240 mg twice daily (BID) and three times daily (TID) in patient subgroups stratified according to baseline demographic and disease characteristics including gender, age, relapse history, McDonald criteria, treatment history, Expanded Disability Status Scale score, T2 lesion volume, and gadolinium-enhancing lesions. BG-12 treatment demonstrated generally consistent benefits on relapse-related outcomes across patient subgroups, reflecting the positive findings in the overall CONFIRM study population. Treatment with BG-12 BID and TID reduced the ARR and the proportion of patients relapsed at 2 years compared with placebo in all subgroups analyzed. Reductions in ARR with BG-12 BID versus placebo ranged from 34% [rate ratio 0.664 (95% confidence interval 0.422-1.043)] to 53% [0.466 (0.313-0.694)] and from 13% [0.870 (0.551-1.373)] to 67% [0.334 (0.226-0.493)] with BG-12 TID versus placebo. Treatment with glatiramer acetate reduced the ARR and the proportion of patients relapsed at 2 years compared with placebo in most patient subgroups. The results of these analyses indicate that treatment with BG-12 is effective on relapses across a broad range of patients with relapsing-remitting multiple sclerosis with varied demographic and disease characteristics.

  12. Multiple resistance to glyphosate, paraquat and ACCase-inhibiting herbicides in Italian ryegrass populations from California: confirmation and mechanisms of resistance.

    Science.gov (United States)

    Tehranchian, Parsa; Nandula, Vijay; Jugulam, Mithila; Putta, Karthik; Jasieniuk, Marie

    2018-04-01

    Glyphosate, paraquat and acetyl CoA carboxylase (ACCase)-inhibiting herbicides are widely used in California annual and perennial cropping systems. Recently, glyphosate, paraquat, and ACCase- and acetolactate synthase (ALS)-inhibitor resistance was confirmed in several Italian ryegrass populations from the Central Valley of California. This research characterized the possible mechanisms of resistance. Multiple-resistant populations (MR1, MR2) are resistant to several herbicides from at least three modes of action. Dose-response experiments revealed that the MR1 population was 45.9-, 122.7- and 20.5-fold, and the MR2 population was 24.8-, 93.9- and 4.0-fold less susceptible to glyphosate, sethoxydim and paraquat, respectively, than the susceptible (Sus) population. Accumulation of shikimate in Sus plants was significantly greater than in MR plants 32 h after light pretreatments. Glyphosate resistance in MR plants was at least partially due to Pro106-to-Ala and Pro106-to-Thr substitutions at site 106 of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). EPSPS gene copy number and expression level were similar in plants from the Sus and MR populations. An Ile1781-to-Leu substitution in ACCase gene of MR plants conferred a high level of resistance to sethoxydim and cross-resistance to other ACCase-inhibitors. Radiolabeled herbicide studies and phosphorimaging indicated that MR plants had restricted translocation of 14 C-paraquat to untreated leaves compared to Sus plants. This study shows that multiple herbicide resistance in Italian ryegrass populations in California, USA, is due to both target-site and non-target-site resistance mechanisms. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  13. Tumefactive foreign body giant cell reaction following high-pressure paint injection injury: A case report and review of literature.

    Science.gov (United States)

    Mauzo, Shakuntala H; Swaby, Michael G; Covinsky, Michael H

    2017-05-01

    High-pressure paint injection injury is an uncommon but well-described injury. The histologic features of long-term paint injection injury with retained material are less recognized. A 46-year-old male presented clinically as "recurrent giant cell tumor of tendon sheath." The right index finger demonstrated fusiform enlargement by a pigmented mass with diffuse infiltration into the soft tissue of the hand. Histologically the tumor showed multiple giant cells in a fibrotic stroma extending into the dermis. There were multiple types of foreign material including diffuse brown black pigment, weakly optically polarizing foreign material and white inclusions with a "train track" appearance. The cells were positive for CD68 and negative for S100 antigen. Further investigation revealed that the patient had a history of high-pressure paint injection injury to his digit 6 years prior. Foreign material injected under high pressure into tissues may result in a pseudo-neoplastic foreign body granulomatous reaction that can mimic giant cell tumor of tendon sheath. Our case demonstrates that this reaction can be florid and can have slow growth over years. A high index of suspicion, a good clinical history and careful examination can distinguish these 2 entities. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. CERN confirms LHC schedule

    CERN Multimedia

    2003-01-01

    The CERN Council held its 125th session on 20 June. Highlights of the meeting included confirmation that the LHC is on schedule for a 2007 start-up, and the announcement of a new organizational structure in 2004.

  15. Performance Confirmation Plan

    International Nuclear Information System (INIS)

    Lindner, E.N.

    2000-01-01

    As described, the purpose of the Performance Confirmation Plan is to specify monitoring, testing, and analysis activities for evaluating the accuracy and adequacy of the information used to determine that performance objectives for postclosure will be met. This plan defines a number of specific performance confirmation activities and associated test concepts in support of the MGR that will be implemented to fulfill this purpose. In doing so, the plan defines an approach to identify key factors and processes, predict performance, establish tolerances and test criteria, collect data (through monitoring, testing, and experiments), analyze these data, and recommend appropriate action. The process of defining which factors to address under performance confirmation incorporates input from several areas. In all cases, key performance confirmation factors are those factors which are: (1) important to safety, (2) measurable and predictable, and (3) relevant to the program (i.e., a factor that is affected by construction, emplacement, or is a time-dependent variable). For the present version of the plan, performance confirmation factors important to safety are identified using the principal factors from the RSS (CRWMS M and O 2000a) (which is derived from TSPA analyses) together with other available performance assessment analyses. With this basis, key performance confirmation factors have been identified, and test concepts and test descriptions have been developed in the plan. Other activities are also incorporated into the performance confirmation program outside of these key factors. Additional activities and tests have been incorporated when they are prescribed by requirements and regulations or are necessary to address data needs and model validation requirements relevant to postclosure safety. These other activities have been included with identified factors to construct the overall performance confirmation program

  16. Performance Confirmation Plan

    International Nuclear Information System (INIS)

    Lindner, E.N.

    2000-01-01

    As described, the purpose of the Performance Confirmation Plan is to specify monitoring, testing, and analysis activities for evaluating the accuracy and adequacy of the information used to determine that performance objectives for postclosure will be met. This plan defines a number of specific performance confirmation activities and associated test concepts in support of the MGR that will be implemented to fulfill this purpose. In doing so, the plan defines an approach to identify key factors and processes, predict performance, establish tolerances and test criteria, collect data (through monitoring, testing, and experiments), analyze these data, and recommend appropriate action. The process of defining which factors to address under performance confirmation incorporates input from several areas. In all cases, key performance confirmation factors are those factors which are: (1) important to safety, (2) measurable and predictable, and (3) relevant to the program (i.e., a factor that i s affected by construction, emplacement, or is a time-dependent variable). For the present version of the plan, performance confirmation factors important to safety are identified using the principal factors from the RSS (CRWMS M and O 2000a) (which is derived from TSPA analyses) together with other available performance assessment analyses. With this basis, key performance confirmation factors have been identified, and test concepts and test descriptions have been developed in the plan. Other activities are also incorporated into the performance confirmation program outside of these key factors. Additional activities and tests have been incorporated when they are prescribed by requirements and regulations or are necessary to address data needs and model validation requirements relevant to postclosure safety. These other activities have been included with identified factors to construct the overall performance confirmation program

  17. Repository performance confirmation

    International Nuclear Information System (INIS)

    Hansen, Francis D.

    2011-01-01

    Repository performance confirmation links the technical bases of repository science and societal acceptance. This paper explores the myriad aspects of what has been labeled performance confirmation in U.S. programs, which involves monitoring as a collection of distinct activities combining technical and social significance in radioactive waste management. This paper is divided into four parts: (1) A distinction is drawn between performance confirmation monitoring and other testing and monitoring objectives; (2) A case study illustrates confirmation activities integrated within a long-term testing and monitoring strategy for Yucca Mountain; (3) A case study reviews compliance monitoring developed and implemented for the Waste Isolation Pilot Plant; and (4) An approach for developing, evaluating and implementing the next generation of performance confirmation monitoring is presented. International interest in repository monitoring is exhibited by the European Commission Seventh Framework Programme 'Monitoring Developments for Safe Repository Operation and Staged Closure' (MoDeRn) Project. The MoDeRn partners are considering the role of monitoring in a phased approach to the geological disposal of radioactive waste. As repository plans advance in different countries, the need to consider monitoring strategies within a controlled framework has become more apparent. The MoDeRn project pulls together technical and societal experts to assimilate a common understanding of a process that could be followed to develop a monitoring program. A fundamental consideration is the differentiation of confirmation monitoring from the many other testing and monitoring activities. Recently, the license application for Yucca Mountain provided a case study including a technical process for meeting regulatory requirements to confirm repository performance as well as considerations related to the preservation of retrievability. The performance confirmation plan developed as part of the

  18. Multiplicity

    Science.gov (United States)

    1991-04-01

    Virginia, 388 U.S. 1 (1967)(criminal statute prohibiting interracial marriages held unconstitutional violation of the Equal Protection and Due Process...such sentences does not violate the Constitution."°2 7 In effect , the double jeopardy protection from multiple punishments is coextensive with...unaware of what it accomplished . . . . In effect , the Blockburger test establishes a presumption of legislative intent: if each of two statutes

  19. Características histológicas de la tumefacción frontal de Melanophryniscus (Amphibia: Anura: Bufonidae Histological features of the frontal tumefaction in Melanophryniscus (Amphibia: Anura: Bufonidae

    Directory of Open Access Journals (Sweden)

    DANIEL E. NAYA

    2004-12-01

    Full Text Available Se analizó la histología tegumentaria de la región cefálica en seis especies del género Melanophryniscus, pertenecientes a los grupos stelzneri (4 y tumifrons (2, con el objetivo de esclarecer la estructura de la tumefacción frontal y su posible función. Las características generales de la histología del grupo stelzneri, coincidieron con las descripciones tegumentarias existentes para el género. Sin embargo, la región cefálica frontal en las dos especies del grupo tumifrons muestran cambios histológicos correlacionados a la tumefacción frontal. Esta estructura presenta una organización similar a otras macroglándulas presentes en la dermis de anuros (e.g., parotoides, paracnémicas, y por tanto se propone el nombre de macroglándula frontal para la misma. Los resultados obtenidos sugieren un rol defensivo para esta macroglándulaWe analyzed the histology of skin from the head region of six species of Melanophryniscus, belonging to the stelzneri (4 and tumifrons (2 groups, to understand the frontal tumefaction structure and function. The histological features of the skin in the stelzneri group are in agreement with the current description for the genus Melanophryniscus. However, the features of the skin on the anterior head region of M. tumifrons shows several changes associated with the frontal tumefaction. This structure consists of a macrogland of similar organization to that of other dermic glands (e.g., parotoid, paracnemid of amphibians. We propose the name frontal macrogland for this structure. Our results suggest a possible defense role for this macrogland

  20. Newsletter Subscribe Confirmation | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Thank you. Please check your email to confirm your subscription to the IDRC Bulletin. Please note: the link in your confirmation email is valid for 3 days, so please reply promptly. What we do · Funding · Resources · About IDRC. Knowledge. Innovation. Solutions. Careers · Contact Us · Site map. Sign up now for IDRC news ...

  1. Continuous Silicate Utilization Over Multiple 14L:10D Day:Night Cycles Confirms Night Metabolism in Lake Michigan Diatom Enrichments Using Either Nitrate or Ammonium as a Nitrogen Source

    Science.gov (United States)

    Soderling, M.; Aguilar, C.; Cuhel, R. L.

    2016-02-01

    Diatoms are single-celled organelle containing eukaryotes living in "glass houses". As diatoms only take up silica when they replicate, measuring the amounts of dissolved and particulate silicate were an important aspect of this study. Silica was used as a proxy of the diatom reproduction. Depending on growth conditions, some algal species divide throughout the day and night; this suggests that protein synthesis can be an important component of algal night metabolism and hence nitrogen utilization. The goal of this experiment was to measure the amount of night protein synthesis occurring in a culture of diatoms from Lake Michigan. Diatoms were enriched with light for energy and excess nutrients—including phosphate, silicate, nitrate and limited ammonium for some—along with use of physical separation methods. Growing conditions were prepared in a way which anticipated the diatoms would synchronize to a 14:10 day/night cycle and store energy, during their day phase, to use for night protein synthesis and replication. Their growth was monitored by taking samples before and after the transitions of light to dark along with midday and midnight samples. Assays of dissolved and particulate silicate were used to measure utilization, which confirmed their nighttime growth. As hypothesized, the diatoms had significant growth during their night phase. There were decreases in the nighttime dissolved silicate and increases in the nighttime particulate silicate. When available, the diatoms preferred to use ammonium instead of nitrate. Cell division during the night phase indicated sufficient daytime energy storage to fuel night protein synthesis and cell replication. Uptake of nutrients occurred at night almost as if the "sun" did not set. There was continuous growth of this photosynthetic community.

  2. Quantitative morphological descriptors confirm traditionally ...

    African Journals Online (AJOL)

    SARAH

    2015-09-30

    Sep 30, 2015 ... J. Appl. Biosci. 2015 Quantitative morphological descriptors confirm traditionally classified morphotypes of Pentadesma butyracea Sabine (clusiaceae). 8736. Quantitative morphological descriptors ...... Hijmans RJ, Cameron SE, Parra JL, Jones PG, Jarvis. A, 2004. The WorldClim interpolated global.

  3. Gender Confirmation Surgery: Guiding Principles.

    Science.gov (United States)

    Schechter, Loren S; D'Arpa, Salvatore; Cohen, Mimis N; Kocjancic, Ervin; Claes, Karel E Y; Monstrey, Stan

    2017-06-01

    At this time, no formal training or educational programs exist for surgeons or surgery residents interested in performing gender confirmation surgeries. To propose guiding principles designed to aid with the development of formal surgical training programs focused on gender confirmation surgery. We use expert opinion to provide a "first of its kind" framework for training surgeons to care for transgender and gender nonconforming individuals. We describe a multidisciplinary treatment model that describes an educational philosophy and the institution of quality parameters. This article represents the first step in the development of a structured educational program for surgical training in gender confirmation procedures. The World Professional Association for Transgender Health Board of Directors unanimously approved this article as the framework for surgical training. This article builds a framework for surgical training. It is designed to provide concepts that will likely be modified over time and based on additional data and evidence gathered through outcome measurements. We present an initial step in the formation of educational and technical guidelines for training surgeons in gender confirmation procedures. Schechter LS, D'Arpa S, Cohen MN, et al. Gender Confirmation Surgery: Guiding Principles. J Sex Med 2017;14:852-856. Copyright © 2017 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

  4. Constructing, Confirming, and Contesting Icons

    DEFF Research Database (Denmark)

    Mortensen, Mette

    2017-01-01

    to their reception as they help shape and delimit the publics and discourses surrounding visual icons. This article draws on existing research on visual icons and appropriations to develop a theoretical framework for how appropriations construct, confirm and contest icons and how personification constitutes the main......This article argues that appropriations are central to both the production and reception of visual icons. Appropriations are instrumental in iconization processes as they confirm and consolidate the iconic status by recycling the image in question. At the same time, appropriations are vital...... of these appropriations, two overall modes are singled out: the appropriations either decontextualize or recontextualize the figure of Kurdi. The two next analytical cases test the limits of decontextualization and recontextualization: Chinese artist Ai Weiwei decontextualizes the Kurdi imagery in a controversial...

  5. Performance Confirmation Data Aquisition System

    Energy Technology Data Exchange (ETDEWEB)

    D.W. Markman

    2000-10-27

    The purpose of this analysis is to identify and analyze concepts for the acquisition of data in support of the Performance Confirmation (PC) program at the potential subsurface nuclear waste repository at Yucca Mountain. The scope and primary objectives of this analysis are to: (1) Review the criteria for design as presented in the Performance Confirmation Data Acquisition/Monitoring System Description Document, by way of the Input Transmittal, Performance Confirmation Input Criteria (CRWMS M&O 1999c). (2) Identify and describe existing and potential new trends in data acquisition system software and hardware that would support the PC plan. The data acquisition software and hardware will support the field instruments and equipment that will be installed for the observation and perimeter drift borehole monitoring, and in-situ monitoring within the emplacement drifts. The exhaust air monitoring requirements will be supported by a data communication network interface with the ventilation monitoring system database. (3) Identify the concepts and features that a data acquisition system should have in order to support the PC process and its activities. (4) Based on PC monitoring needs and available technologies, further develop concepts of a potential data acquisition system network in support of the PC program and the Site Recommendation and License Application.

  6. Opinion dynamics with confirmation bias.

    Directory of Open Access Journals (Sweden)

    Armen E Allahverdyan

    Full Text Available Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices. Prior theoretical research of this phenomenon has mainly focused on its economic implications possibly missing its potential connections with broader notions of cognitive science.We formulate a (non-Bayesian model for revising subjective probabilistic opinion of a confirmationally-biased agent in the light of a persuasive opinion. The revision rule ensures that the agent does not react to persuasion that is either far from his current opinion or coincides with it. We demonstrate that the model accounts for the basic phenomenology of the social judgment theory, and allows to study various phenomena such as cognitive dissonance and boomerang effect. The model also displays the order of presentation effect-when consecutively exposed to two opinions, the preference is given to the last opinion (recency or the first opinion (primacy -and relates recency to confirmation bias. Finally, we study the model in the case of repeated persuasion and analyze its convergence properties.The standard Bayesian approach to probabilistic opinion revision is inadequate for describing the observed phenomenology of persuasion process. The simple non-Bayesian model proposed here does agree with this phenomenology and is capable of reproducing a spectrum of effects observed in psychology: primacy-recency phenomenon, boomerang effect and cognitive dissonance. We point out several limitations of the model that should motivate its future development.

  7. Opinion dynamics with confirmation bias.

    Science.gov (United States)

    Allahverdyan, Armen E; Galstyan, Aram

    2014-01-01

    Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices. Prior theoretical research of this phenomenon has mainly focused on its economic implications possibly missing its potential connections with broader notions of cognitive science. We formulate a (non-Bayesian) model for revising subjective probabilistic opinion of a confirmationally-biased agent in the light of a persuasive opinion. The revision rule ensures that the agent does not react to persuasion that is either far from his current opinion or coincides with it. We demonstrate that the model accounts for the basic phenomenology of the social judgment theory, and allows to study various phenomena such as cognitive dissonance and boomerang effect. The model also displays the order of presentation effect-when consecutively exposed to two opinions, the preference is given to the last opinion (recency) or the first opinion (primacy) -and relates recency to confirmation bias. Finally, we study the model in the case of repeated persuasion and analyze its convergence properties. The standard Bayesian approach to probabilistic opinion revision is inadequate for describing the observed phenomenology of persuasion process. The simple non-Bayesian model proposed here does agree with this phenomenology and is capable of reproducing a spectrum of effects observed in psychology: primacy-recency phenomenon, boomerang effect and cognitive dissonance. We point out several limitations of the model that should motivate its future development.

  8. Performance Confirmation Data Acquisition System

    International Nuclear Information System (INIS)

    D.W. Markman

    2000-01-01

    The purpose of this analysis is to identify and analyze concepts for the acquisition of data in support of the Performance Confirmation (PC) program at the potential subsurface nuclear waste repository at Yucca Mountain. The scope and primary objectives of this analysis are to: (1) Review the criteria for design as presented in the Performance Confirmation Data Acquisition/Monitoring System Description Document, by way of the Input Transmittal, Performance Confirmation Input Criteria (CRWMS M and O 1999c). (2) Identify and describe existing and potential new trends in data acquisition system software and hardware that would support the PC plan. The data acquisition software and hardware will support the field instruments and equipment that will be installed for the observation and perimeter drift borehole monitoring, and in-situ monitoring within the emplacement drifts. The exhaust air monitoring requirements will be supported by a data communication network interface with the ventilation monitoring system database. (3) Identify the concepts and features that a data acquisition system should have in order to support the PC process and its activities. (4) Based on PC monitoring needs and available technologies, further develop concepts of a potential data acquisition system network in support of the PC program and the Site Recommendation and License Application

  9. Bacteriologically confirmed tuberculosis in children

    International Nuclear Information System (INIS)

    Ozere, I.; Sele, A.; Ozolina, A.

    2005-01-01

    Tuberculosis in children and adults is a growing problem with important public health implications. In Latvia the incidence of tuberculosis (TB) in children up to age 14 has increased from 7,1 per 100000 in 1992 to 28,8 per 100000 in 2003. The diagnosis of TB is confirmed by isolation and identification of M. tuberculosis (MT) from clinical specimen. Confirmation of the disease, however, is difficult in children due to poor bacilli excretion and even under the best circumstances only about 30-40% of pediatric TB cases are proved bacteriologically. Of the 370 pediatric TB cases diagnosed between January 1, 2001 and December 1, 2003 in Latvia, 53 (14,3%) were confirmed bacteriologically. The clinical, radiological, immunological and anamnestic features of confirmed TB can serve as cornerstones for diagnosing of TB, when culture is not available. Objective To evaluate the sensitivity of diagnostic criteria of TB, clinical and radiological manifestation of TB and drug susceptibility of MT isolated also. Methods All consecutive children (53 in total) up to age 14 diagnosed with bacteriologically confirmed TB during 01.01.2001. -01.12.2003. were prospectively evaluated for reasons mentioned above. Results Of the 53 children identified all but one had respiratory tract TB. 17(32,1 %) children were under 4 years of age, 9 (17%) children were 5-9 years old, but 27 (50,9%) patients were 10-14 years old. During evaluation data on TB source case were found in addition in 13 children and total TB contact history was positive in 37 (69,8%) patients. All clinical and radiographical forms of respiratory tract TB were diagnosed. The most common encountered forms were intrathoracic adenopathy in 10 (18,9%) cases and TB pneumonia in 6 (11,3%) cases in children aged 10-14 years. lnthrathoracic adenopathy associated with segmental parenchymal lesion was the most common form in children under 4 years of age -7 (13,2%) cases respectively. Conclusions 1. The clinical and radiological

  10. Model confirmation in climate economics.

    Science.gov (United States)

    Millner, Antony; McDermott, Thomas K J

    2016-08-02

    Benefit-cost integrated assessment models (BC-IAMs) inform climate policy debates by quantifying the trade-offs between alternative greenhouse gas abatement options. They achieve this by coupling simplified models of the climate system to models of the global economy and the costs and benefits of climate policy. Although these models have provided valuable qualitative insights into the sensitivity of policy trade-offs to different ethical and empirical assumptions, they are increasingly being used to inform the selection of policies in the real world. To the extent that BC-IAMs are used as inputs to policy selection, our confidence in their quantitative outputs must depend on the empirical validity of their modeling assumptions. We have a degree of confidence in climate models both because they have been tested on historical data in hindcasting experiments and because the physical principles they are based on have been empirically confirmed in closely related applications. By contrast, the economic components of BC-IAMs often rely on untestable scenarios, or on structural models that are comparatively untested on relevant time scales. Where possible, an approach to model confirmation similar to that used in climate science could help to build confidence in the economic components of BC-IAMs, or focus attention on which components might need refinement for policy applications. We illustrate the potential benefits of model confirmation exercises by performing a long-run hindcasting experiment with one of the leading BC-IAMs. We show that its model of long-run economic growth-one of its most important economic components-had questionable predictive power over the 20th century.

  11. Opinion Dynamics with Confirmation Bias

    Science.gov (United States)

    Allahverdyan, Armen E.; Galstyan, Aram

    2014-01-01

    Background Confirmation bias is the tendency to acquire or evaluate new information in a way that is consistent with one's preexisting beliefs. It is omnipresent in psychology, economics, and even scientific practices. Prior theoretical research of this phenomenon has mainly focused on its economic implications possibly missing its potential connections with broader notions of cognitive science. Methodology/Principal Findings We formulate a (non-Bayesian) model for revising subjective probabilistic opinion of a confirmationally-biased agent in the light of a persuasive opinion. The revision rule ensures that the agent does not react to persuasion that is either far from his current opinion or coincides with it. We demonstrate that the model accounts for the basic phenomenology of the social judgment theory, and allows to study various phenomena such as cognitive dissonance and boomerang effect. The model also displays the order of presentation effect–when consecutively exposed to two opinions, the preference is given to the last opinion (recency) or the first opinion (primacy) –and relates recency to confirmation bias. Finally, we study the model in the case of repeated persuasion and analyze its convergence properties. Conclusions The standard Bayesian approach to probabilistic opinion revision is inadequate for describing the observed phenomenology of persuasion process. The simple non-Bayesian model proposed here does agree with this phenomenology and is capable of reproducing a spectrum of effects observed in psychology: primacy-recency phenomenon, boomerang effect and cognitive dissonance. We point out several limitations of the model that should motivate its future development. PMID:25007078

  12. Confirmation of shutdown cooling effects

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Kotaro, E-mail: ksato@nelted.co.jp; Tabuchi, Masato; Sugimura, Naoki; Tatsumi, Masahiro [Nuclear Engineering, Limited, 1-3-7 Tosabori Nishi-ku, Osaka-shi, Osaka 550-0001 (Japan)

    2015-12-31

    After the Fukushima accidents, all nuclear power plants in Japan have gradually stopped their operations and have long periods of shutdown. During those periods, reactivity of fuels continues to change significantly especially for high-burnup UO{sub 2} fuels and MOX fuels due to radioactive decays. It is necessary to consider these isotopic changes precisely, to predict neutronics characteristics accurately. In this paper, shutdown cooling (SDC) effects of UO{sub 2} and MOX fuels that have unusual operation histories are confirmed by the advanced lattice code, AEGIS. The calculation results show that the effects need to be considered even after nuclear power plants come back to normal operation.

  13. Confirmation of shutdown cooling effects

    Science.gov (United States)

    Sato, Kotaro; Tabuchi, Masato; Sugimura, Naoki; Tatsumi, Masahiro

    2015-12-01

    After the Fukushima accidents, all nuclear power plants in Japan have gradually stopped their operations and have long periods of shutdown. During those periods, reactivity of fuels continues to change significantly especially for high-burnup UO2 fuels and MOX fuels due to radioactive decays. It is necessary to consider these isotopic changes precisely, to predict neutronics characteristics accurately. In this paper, shutdown cooling (SDC) effects of UO2 and MOX fuels that have unusual operation histories are confirmed by the advanced lattice code, AEGIS. The calculation results show that the effects need to be considered even after nuclear power plants come back to normal operation.

  14. Performance confirmation data acquisition system

    International Nuclear Information System (INIS)

    McAffee, D.A.; Raczka, N.T.

    1997-01-01

    As part of the Viability Assessment (VA) work, this QAP-3-9 document presents and evaluates a comprehensive set of viable concepts for collecting Performance Confirmation (PC) related data. The concepts include: monitoring subsurface repository air temperatures, humidity levels and gaseous emissions via the subsurface ventilation systems, and monitoring the repository geo-technical parameters and rock mass from bore-holes located along the perimeter main drifts and throughout a series of human-rated Observation Drifts to be located in a plane 25 meters above the plane of the emplacement drifts. A key element of this document is the development and analysis of a purposed multi-purpose Remote Inspection Gantry that would provide direct, real-time visual, thermal, and radiological monitoring of conditions inside operational emplacement drifts and close-up observations of in-situ Waste Packages. Preliminary finite-element analyses are presented that indicate the technological feasibility of operating an inspection gantry inside the operational emplacement drifts for short inspection missions lasting 2--3 hours. Overall reliability, availability, and maintainability of the PC data collection concepts are discussed. Preliminary concepts for PC data collection network are also provided

  15. Performance confirmation data acquisition system

    Energy Technology Data Exchange (ETDEWEB)

    McAffee, D.A.; Raczka, N.T. [Yucca Mountain Project, Las Vegas, NV (United States)

    1997-12-31

    As part of the Viability Assessment (VA) work, this QAP-3-9 document presents and evaluates a comprehensive set of viable concepts for collecting Performance Confirmation (PC) related data. The concepts include: monitoring subsurface repository air temperatures, humidity levels and gaseous emissions via the subsurface ventilation systems, and monitoring the repository geo-technical parameters and rock mass from bore-holes located along the perimeter main drifts and throughout a series of human-rated Observation Drifts to be located in a plane 25 meters above the plane of the emplacement drifts. A key element of this document is the development and analysis of a purposed multi-purpose Remote Inspection Gantry that would provide direct, real-time visual, thermal, and radiological monitoring of conditions inside operational emplacement drifts and close-up observations of in-situ Waste Packages. Preliminary finite-element analyses are presented that indicate the technological feasibility of operating an inspection gantry inside the operational emplacement drifts for short inspection missions lasting 2--3 hours. Overall reliability, availability, and maintainability of the PC data collection concepts are discussed. Preliminary concepts for PC data collection network are also provided.

  16. Pattern Recognition of the Multiple Sclerosis Syndrome

    Directory of Open Access Journals (Sweden)

    Rana K. Zabad

    2017-10-01

    Full Text Available During recent decades, the autoimmune disease neuromyelitis optica spectrum disorder (NMOSD, once broadly classified under the umbrella of multiple sclerosis (MS, has been extended to include autoimmune inflammatory conditions of the central nervous system (CNS, which are now diagnosable with serum serological tests. These antibody-mediated inflammatory diseases of the CNS share a clinical presentation to MS. A number of practical learning points emerge in this review, which is geared toward the pattern recognition of optic neuritis, transverse myelitis, brainstem/cerebellar and hemispheric tumefactive demyelinating lesion (TDL-associated MS, aquaporin-4-antibody and myelin oligodendrocyte glycoprotein (MOG-antibody NMOSD, overlap syndrome, and some yet-to-be-defined/classified demyelinating disease, all unspecifically labeled under MS syndrome. The goal of this review is to increase clinicians’ awareness of the clinical nuances of the autoimmune conditions for MS and NMSOD, and to highlight highly suggestive patterns of clinical, paraclinical or imaging presentations in order to improve differentiation. With overlay in clinical manifestations between MS and NMOSD, magnetic resonance imaging (MRI of the brain, orbits and spinal cord, serology, and most importantly, high index of suspicion based on pattern recognition, will help lead to the final diagnosis.

  17. Calibration and Confirmation in Geophysical Models

    Science.gov (United States)

    Werndl, Charlotte

    2016-04-01

    For policy decisions the best geophysical models are needed. To evaluate geophysical models, it is essential that the best available methods for confirmation are used. A hotly debated issue on confirmation in climate science (as well as in philosophy) is the requirement of use-novelty (i.e. that data can only confirm models if they have not already been used before. This talk investigates the issue of use-novelty and double-counting for geophysical models. We will see that the conclusions depend on the framework of confirmation and that it is not clear that use-novelty is a valid requirement and that double-counting is illegitimate.

  18. Funding Alert Subscribe Confirmation | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Thank you. Please check your email ( ) to confirm your subscription to the IDRC Funding Alerts. Please note: the link in your confirmation email is valid for 3 days, so please reply promptly. We fund researchers driving global change. Careers · Contact Us · Subscribe · Unsubscribe · Site map. Follow us; Facebook · Twitter ...

  19. Experience with confirmation measurement at Los Alamos

    International Nuclear Information System (INIS)

    Marshall, R.S.; Wagner, R.P.; Hsue, F.

    1985-01-01

    Confirmation measurements are used at Los Alamos in support of incoming and outgoing shipment accountibility and for support of both at 235 U and Pu inventories. Statistical data are presented to show the consistency of measurements on items of identical composition and on items measured at two facilitis using similar instruments. A description of confirmation measurement techniques used in support of 235 U and Pu inventories and a discussion on the ability of the measurements to identify items with misstated SNM are given

  20. Experience with confirmation measurement at Los Alamos

    International Nuclear Information System (INIS)

    Marshall, R.S.; Wagner, R.P.

    1985-01-01

    Confirmation measurements are used at Los Alamos in support of incoming and outgoing shipment accountability and for support of both 235 U and Pu inventories. Statistical data are presented to show the consistency of measurements on items of identical composition and on items measured at two facilities using similar instruments. A description of confirmation measurement techniques used in support of 235 U and Pu inventories and a discussion on the ability of the measurements to identify items with misstated SNM are given

  1. Nonintrusive irradiated fuel inventory confirmation technique

    Energy Technology Data Exchange (ETDEWEB)

    Dowdy, E.J.; Nicholson, N.; Caldwell, J.T.

    1980-01-01

    Successful tests showing correlation between the intensity of the Cerenkov glow surrounding irradiated fuel assemblies in water-filled spent fuel storage ponds and the exposure and cooling times of assemblies have been concluded. Fieldable instruments used in subsequent tests confirmed that such measurements can be made easily and rapidly, without fuel assembly movement or the introduction of apparatus into the storage ponds.

  2. Ultrasonography for confirmation of gastric tube placement.

    Science.gov (United States)

    Tsujimoto, Hiraku; Tsujimoto, Yasushi; Nakata, Yukihiko; Akazawa, Mai; Kataoka, Yuki

    2017-04-17

    Gastric tubes are commonly used for the administration of drugs and tube feeding for people who are unable to swallow. Feeding via a tube misplaced in the trachea can result in severe pneumonia. Therefore, the confirmation of tube placement in the stomach after tube insertion is important. Recent studies have reported that ultrasonography provides good diagnostic accuracy estimates in the confirmation of appropriate tube placement. Hence, ultrasound could provide a promising alternative to X-rays in the confirmation of tube placement, especially in settings where X-ray facilities are unavailable or difficult to access. To assess the diagnostic accuracy of ultrasound for gastric tube placement confirmation. We searched the Cochrane Library (2016, Issue 3), MEDLINE (to March 2016), Embase (to March 2016), National Institute for Health Research (NIHR) PROSPERO Register (to May 2016), Aggressive Research Intelligence Facility Databases (to May 2016), ClinicalTrials.gov (to May 2016), ISRCTN registry (May 2016), World Health Organization International Clinical Trials Registry Platform (to May 2016) and reference lists of articles, and contacted study authors. We included studies that evaluated the diagnostic accuracy of naso- and orogastric tube placement confirmed by ultrasound visualization using X-ray visualization as the reference standard. We included cross-sectional studies, and case-control studies. We excluded case series or case reports. Studies were excluded if X-ray visualization was not the reference standard or if the tube being placed was a gastrostomy or enteric tube. Two review authors independently assessed the risk of bias and extracted data from each of the included studies. We contacted authors of the included studies to obtain missing data. We identified 10 studies (545 participants and 560 tube insertions) which met our inclusion criteria.No study was assigned low risk of bias or low concern in every QUADAS-2 domain. We judged only three (30

  3. PERFORMANCE CONFIRMATION IN-SITU INSTRUMENTATION

    International Nuclear Information System (INIS)

    N.T. Raczka

    2000-01-01

    The purpose of this document is to identify and analyze the types of in-situ instruments and methods that could be used in support of the data acquisition portion of the Performance Confirmation (PC) program at the potential nuclear waste repository at Yucca Mountain. The PC program will require geomechanical , geophysical, thermal, and hydrologic instrumentation of several kinds. This analysis is being prepared to document the technical issues associated with each type of measurement during the PC period. This analysis utilizes the ''Performance Confirmation Input Criteria'' (CRWMS M andO 1999a) as its starting point. The scope of this analysis is primarily on the period after the start of waste package emplacement and before permanent closure of the repository, a period lasting between 15 and 300 years after last package emplacement (Stroupe 2000, Attachment 1, p. 1). The primary objectives of this analysis are to: (1) Review the design criteria as presented in the ''Performance Confirmation Input Criteria'' (CRWMS M andO 1999a). The scope of this analysis will be limited to the instrumentation related to parameters that require continuous monitoring of the conditions underground. (2) Preliminary identification and listing of the data requirements and parameters as related to the current repository layout in support of PC monitoring. (3) Preliminary identification of methods and instrumentation for the acquisition of the required data. Although the ''Performance Confirmation Input Criteria'' (CRWMS M andO 1999a) defines a broad range of data that must be obtained from a variety of methods, the focus of this analysis is on instrumentation related to the performance of the rock mass and the formation of water in the repository environment, that is obtainable from in-situ observation, testing, and monitoring

  4. Heat Flux Inhibition by Whistlers: Experimental Confirmation

    International Nuclear Information System (INIS)

    Eichler, D.

    2002-01-01

    Heat flux in weakly magnetized collisionless plasma is, according to theoretical predictions, limited by whistler turbulence that is generated by heat flux instabilities near threshold. Observations of solar wind electrons by Gary and coworkers appear to confirm the limit on heat flux as being roughly the product of the magnetic energy density and the electron thermal velocity, in agreement with prediction (Pistinner and Eichler 1998)

  5. Troubleshooting Requests e-mail Confirmation

    CERN Document Server

    TS Department

    2004-01-01

    In an ongoing effort to improve quality of the repair requests, a new e-mail confirmation automatic system will be implemented starting from the 21st October. All repair requests transmitted to the TCR (72201) or the FM Helpdesk (77777) will be confirmed in an e-mail to the requestor, provided that the latter has a valid e-mail address in the HR database. The e-mail will contain a reference number, a brief description of the problem, the location and a contact where more information can be obtained. A second e-mail will be sent when the processing of the repair request is finished. We hope that this initiative will improve the transparency and quality of our service. Helpdesk Troubleshooting Requests (reminder) We remind you that all the repair requests and other communication concerning the CERN machine buildings have to be transmitted to the TCR via 72201, whereas the ones concerning tertiary buildings are handled directly by the FM helpdesk under the phone number 77777, i.e. problems on systems and equ...

  6. [Cutaneous gnathostomiasis, first confirmed case in Colombia].

    Science.gov (United States)

    Jurado, Leonardo F; Palacios, Diana M; López, Rocío; Baldión, Margarita; Matijasevic, Eugenio

    2015-01-01

    Gnathostomiasis is a parasitic zoonosis caused by some species of helminthes belonging to the genus Gnathostoma . It has a wide clinical presentation and its diagnosis is a challenge. Tropical and subtropical countries are endemic, and its transmission is associated with eating raw or undercooked meat from fresh water animals. Increasing global tourism and consuming exotic foods have produced a noticeable rise in cases of the disease in the last decades. However, in our country, there has not been any confirmed case of gnathostomiasis previously reported. We present the case of a 63-year-old Colombian man with an international travel history, who presented with gastrointestinal symptoms. During the hospital stay, he developed a cutaneous lesion on the upper right abdominal quadrant, where later, a larva was found. A morphological study allowed us to identify it as Gnathostoma spinigerum . As such, this is the first report of an imported case of gnathostomiasis confirmed in Colombia. This article describes the principles, etiology, pathogenic cycle and treatment of this disease with special considerations to our patient´s particular features.

  7. Confirming a case of ball lightening production

    Energy Technology Data Exchange (ETDEWEB)

    Balyberdin, V.V.

    1975-01-01

    Model confirmation of ball lightening production was carried out on a three-cascade unit having a working voltage of 150 kV in an air atmosphere at a pressure of 730 to 750 mg Hg std. with C-shaped bending of the lightening drawoff. The electrical discharge parameters were held constant as follows: maximum current amplitude of 7 kA, oscillatory period of the quenched discharge of 6.5 x 10/sup -6/ sec, and energy used up in the unit approximately 2.2 k joules. Moving pictures are presented of the generation of one long luminous bundle displaced from a solid with a velocity up to 240 m/sec, whose luminosity was observed over a period of approximately 3 x 10/sup -3/ sec. Analysis of the experimental results showed that the appearance of plasma bundles is associated with the development of turbulent flows of a low-temperature plasma near the tip of a solid. (SJR)

  8. Confirmation of Kepler Planet Candidates around Giants

    Science.gov (United States)

    Sato, Bun-ei

    2014-01-01

    Detecting planetary transits is extremely valuable not only because it makes an independent confirmation of a planet from Doppler method but also because the photometric transits yield unambiguous information on planet masses and radii, and thus mean density and interior structure, and obliquity of planetary orbits. Planets around giants and subgiants have been intensively surveyed over the decade by precise radial velocity (RV) measurements, mainly from the viewpoint of planet searches around intermediate-mass (1.5-5M⊙) stars. The planets show remarkable properties in their masses and orbital parameters. Unfortunately, however, it is quite difficult to detect transiting ones around such evolved stars because of the large sizes of the host stars. Therefore, our understanding of properties of planets around intermediate-mass stars are still far behind from those around solar-like stars. In S13B, we made the first RV follow-up observations with HDS for the transiting planet candidates around giants found by Kepler space telescope, and identified promising candidates of true transiting planets. Here we propose to take additional RV data for them with HDS in order to make sure that the RV periodicity is the same as the transit one.

  9. Web-Based Honorarium Confirmation System Prototype

    Science.gov (United States)

    Wisswani, N. W.; Catur Bawa, I. G. N. B.

    2018-01-01

    Improving services in academic environment can be applied by regulating salary payment process for all employees. As a form of control to maintain financial transparency, employees should have information concerning salary payment process. Currently, notification process of committee honorarium will be accepted by the employees in a manual manner. The salary will be received by the employee bank account and to know its details, they should go to the accounting unit to find out further information. Though there are some employees entering the accounting unit, they still find difficulty to obtain information about detailed honor information that they received in their accounts. This can be caused by many data collected and to be managed. Based on this issue, this research will design a prototype of web-based system for accounting unit system in order to provide detailed financial transaction confirmation to employee bank accounts that have been informed through mobile banking system. This prototype will be developed with Waterfall method through testing on final users after it is developed through PHP program with MySQL as DBMS

  10. Confirmation of ETI: initial organizational response

    Science.gov (United States)

    Harrison, Albert A.

    2003-08-01

    Perhaps the most crucial responses to the confirmation of extraterrestrial intelligence will come from organizations, rather than from individual people. Among the key organizations that will help shape humanity's response are political institutions such as the US Congress, administrative bodies such as the US Department of State, security agencies, the military, professional societies, and the media. Although popular culture and individual beliefs will affect organizational performance, organizational reactions will depend also on organizational cultures and traditions, administrative structures, communication patterns, decision-making processes, and the actions of other organizations. Prompt and effective responses may be blocked by sociopolitical constraints, jurisdictional disputes, cumbersome structures and procedures, stresses that frequently slow and distort information processing, and potentially counterproductive efforts to maintain positive organizational images. Efforts undertaken by governmental agencies will be hampered by public perceptions of low credibility. Foresight and advance preparation are among the steps that organizations may take to prepare for contact, but conservative values, skepticism towards SETI, and competing organizational priorities make serious preparation unlikely.

  11. Open-Ring Enhancement in Pseudotumoral Multiple Sclerosis: Important Radiological Aspect

    Directory of Open Access Journals (Sweden)

    Frederico Carvalho de Medeiros

    2014-01-01

    Full Text Available Introduction. Observation of open-ring enhancement in magnetic resonance imaging (MRI is considered a specificity marker for diagnosing pseudotumoral multiple sclerosis (MS. This finding is of great value in the differential diagnosis of tumefactive lesions. Case Report. We describe a 55-year-old white woman, with previous history of ovarian cancer and recent history of fatigue and bilateral retroorbital pain. Important bilateral visual impairment evolved over one month. Physical examination detected the presence of right homonymous hemianopia. Cranial MRI showed an expanding lesion with open-ring enhancement. Given the range of diagnostic possibilities, a stereotactic biopsy was performed, and histopathological examination was consistent with an active demyelinating disease. The patient was treated with 1 g of methylprednisolone and symptoms improved following a significant reduction in the lesion. Conclusions. We highlight the MRI results suggestive of pseudotumoral MS, especially open-ring enhancement, which is an important radiologic aspect to diagnosis and can assist in avoiding unnecessary biopsies.

  12. Multiple Pregnancy

    Science.gov (United States)

    ... Education & Events Advocacy For Patients About ACOG Multiple Pregnancy Home For Patients Search FAQs Multiple Pregnancy Page ... Multiple Pregnancy FAQ188, July 2015 PDF Format Multiple Pregnancy Pregnancy How does multiple pregnancy occur? What are ...

  13. Manned in Situ Confirmation of Lunar Ice

    Science.gov (United States)

    Gerené, S. P. B.; Hummeling, R. W. J.; Ockels, W. J.

    A study is performed to investigate the feasibility of a manned expedition to the Moon using the European Ariane-5 launcher. The primary objective of this lunar mission is to confirm the presence of water at the South-Pole craters. It is believed that these permanently shadowed craters contain water in the form of ice. Secondary objective is to perform lunar surface science and making a first step towards a lunar outpost. Early results show that a minimum of two Ariane-5 launches is required. In this `two Ariane' scenario the first launch will bring a Lunar Landing Vehicle (LLV) into low lunar orbit. The second will launch two astronauts in a Crew Transfer Vehicle into a rendez- vous trajectory with the LLV. Arrived at the Moon, the astronauts will enter the LLV, undock from the CTV and land at the designated site located near the rim of the South-Pole Shackleton crater. The transfer strategy for both spacecraft will be the so-called direct transfer, taking about four days. At arrival the LLV will start mapping the landing site at a ground resolution of one meter. As a consequence of the polar orbit, the CTV has to arrive fourteen days later and surface operations can take about twelve days, accumulating in a total mission-duration of 36 days. 32 days for the CTV and 22 days for the LLV. In case a `two Ariane' flight does not posses sufficient capabilities also a `three Ariane' scenario is developed, in which the LLV is split-up into two stages and launched separately. These two will dock at the Moon forming a descent stage and an ascent stage. The third launch will be a CTV. During surface operations, astronauts will set up a solar power unit, install the sample retrieval system and carry out surface science. Samples of the crater floor will be retrieved by means of a probe or robot guided along a cable suspended over the crater rim. Also, this paper shows the way in which European astronauts can be brought to the Moon for other future missions, like the

  14. Multiple sclerosis; Multiple Sklerose

    Energy Technology Data Exchange (ETDEWEB)

    Grunwald, I.Q.; Kuehn, A.L.; Backens, M.; Papanagiotou, P. [Universitaet des Saarlandes, Abteilung fuer Diagnostische und Interventionelle Neuroradiologie, Radiologische Klinik, Homburg/Saar (Germany); Shariat, K. [Universitaet des Saarlandes, Klinik fuer Neurochirurgie, Homburg/Saar (Germany); Kostopoulos, P. [Universitaet des Saarlandes, Klinik fuer Neurologie, Homburg/Saar (Germany)

    2008-06-15

    Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI. (orig.) [German] Die Multiple Sklerose (MS) ist die haeufigste chronisch-entzuendliche Erkrankung des Myelins mit eingesprengten Laesionen im Bereich der weissen Substanz des zentralen Nervensystems. Die Magnetresonanztomographie (MRT) hat bei der Diagnosestellung und Verlaufskontrolle eine Schluesselrolle. Dieser Artikel befasst sich mit Hauptcharakteristika der MR-Bildbebung. (orig.)

  15. Confirmation of antiphospholipid antibody positivity: a year’s results in a cohort of 113 patients

    Directory of Open Access Journals (Sweden)

    A. Ruffatti

    2011-06-01

    Full Text Available Objective: To evaluate the confirmation rate of antiphospholipid antibodies (aPL, to analyze their behaviour at confirmation time, and to study the clinical value of their confirmation. Methods: Blood samples from 380 subjects, enrolled in this study from June 1, 2007 to May 31, 2008, were tested for anti-cardiolipin (aCL and anti-beta2glycoprotein (aβ2GPI antibodies using an ELISA method and for Lupus anticoagulant (LA using a series of clotting tests. The samples of the 113 subjects resulting positive at the first testing time were assayed again to confirm antiphospholipid positivity. Results: aPL positivity was confirmed in 67 out of the 113 subjects (59.3%. Medium-high antibody levels of all, except IgM aCL, aPL/ELISA had a significantly higher confirmation rate with respect to that in subjects with low levels. The confirmation rate in the category I antibody patients (multiple positivity was higher than that in the category II antibody subjects (single positivity. LA positivity was confirmed only when it was associated to other aPL. The cut-off of 40 GPL produced a confirmation rate equal to that resulting from a 99th percentile cut-off. Confirmation of aPL positivity made it possible for us to confirm the diagnosis of antiphospholipid syndrome (APS in 8 out of the 113 subjects originally resulting positive (7,1%. APS clinical features were vascular thrombosis in 4 of these and pregnancy morbidity in the other 4. Conclusions: Our data emphasize aPL positivity confirmation selectivity, and medium-high antibody levels and category I antibodies (multiple positivity had the best confirmation rates.

  16. The French methodology for EBS confirmation and demonstration

    International Nuclear Information System (INIS)

    Plas, F.; Voinis, S.; Mayer, S.

    2007-01-01

    The December 30, 1991 French Waste Act entrusted ANDRA, the French national agency for radioactive waste management, with the task of assessing the feasibility of deep geological disposal of high- and medium-level long-lived waste (HLW and ILW, respectively C-waste and B-waste types in French) plus spent fuel (CU in French). In that context, the 'Dossier 2005 Argile' submitted by ANDRA presents the feasibility assessment - with regard to the technical capacity to accommodate all wastes, to reversibility, and to safety - of a radioactive waste disposal in a clay formation studied at the Meuse/Haute-Marne URL. This report was built upon an iterative approach between site characterisation, design, modelling, phenomenological analysis and safety analysis, in which two principles always guided the elaboration of the safety case: the principle of robustness - repository components must maintain their functionality given reasonable solicitations, taking into account uncertainties on the nature and level of these solicitations; and the principle of demonstrability - safety must be verified without requiring complex demonstrations, and based on multiple lines of evidence/argument (numerical simulation, qualitative arguments such as use of natural analogues, experiments and technological demonstrators). In that respect, the EBS definition, demonstration and confirmation of design is a part of the overall safety case. The 'Dossier 2005 Argile' was submitted to three independent peer reviews. The aim. of this article is to present the methodology that ANDRA implemented in the context of 'Dossier 2005 Argile' for defining, demonstrating and confirming the EBS design as well as the future programme with respect with the new Act of 28 June 2006. (author)

  17. Neuroimaging findings in children with retinopathy-confirmed cerebral malaria

    Energy Technology Data Exchange (ETDEWEB)

    Potchen, Michael J. [Michigan State University, Department of Radiology, 184 Radiology Building, East Lansing, MI 48824-1303 (United States)], E-mail: mjp@rad.msu.edu; Birbeck, Gretchen L. [Michigan State University, International Neurologic and Psychiatric Epidemiology Program, 324 West Fee Hall, East Lansing, MI 48824 (United States)], E-mail: Gretchen.Birbeck@ht.msu.edu; DeMarco, J. Kevin [Michigan State University, Department of Radiology, 184 Radiology Building, East Lansing, MI 48824-1303 (United States)], E-mail: jkd@rad.msu.edu; Kampondeni, Sam D. [University of Malawi, Department of Radiology, Queen Elizabeth Central Hospital, Blantyre (Malawi)], E-mail: kamponde@msu.edu; Beare, Nicholas [St. Paul' s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP (United Kingdom)], E-mail: nbeare@btinternet.com; Molyneux, Malcolm E. [Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine (Malawi); School of Tropical Medicine, University of Liverpool, Liverpool (United Kingdom)], E-mail: mmolyneux999@google.com; Taylor, Terrie E. [Michigan State University, College of Osteopathic Medicine, B309-B West Fee Hall, East Lansing, MI 48824 (United States); University of Malawi, College of Medicine, Blantyre Malaria Project, Blantyre (Malawi)], E-mail: taylort@msu.edu

    2010-04-15

    Purpose: To describe brain CT findings in retinopathy-confirmed, paediatric cerebral malaria. Materials and methods: In this outcomes study of paediatric cerebral malaria, a subset of children with protracted coma during initial presentation was scanned acutely. Survivors experiencing adverse neurological outcomes also underwent a head CT. All children had ophthalmological examination to confirm the presence of the retinopathy specific for cerebral malaria. Independent interpretation of CT images was provided by two neuroradiologists. Results: Acute brain CT findings in three children included diffuse oedema with obstructive hydrocephalus (2), acute cerebral infarctions in multiple large vessel distributions with secondary oedema and herniation (1), and oedema of thalamic grey matter (1). One child who was reportedly normal prior to admission had parenchymal atrophy suggestive of pre-existing CNS injury. Among 56 survivors (9-84 months old), 15 had adverse neurologic outcomes-11/15 had a follow-up head CT, 3/15 died and 1/15 refused CT. Follow-up head CTs obtained 7-18 months after the acute infection revealed focal and multifocal lobar atrophy correlating to regions affected by focal seizures during the acute infection (5/11). Other findings were communicating hydrocephalus (2/11), vermian atrophy (1/11) and normal studies (3/11). Conclusions: The identification of pre-existing imaging abnormalities in acute cerebral malaria suggests that population-based studies are required to establish the rate and nature of incidental imaging abnormalities in Malawi. Children with focal seizures during acute cerebral malaria developed focal cortical atrophy in these regions at follow-up. Longitudinal studies are needed to further elucidate mechanisms of CNS injury and death in this common fatal disease.

  18. Parenting Multiples

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Parenting Multiples KidsHealth / For Parents / Parenting Multiples What's in ... your ability to take care of your babies. Parenting Issues With Multiples It may be difficult to ...

  19. Development of the Performance Confirmation Program at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    G.D. LeCain; D. Barr; D. Weaver; R. Snell; S.W. Goodin; F.D. Hansen

    2006-01-01

    The Yucca Mountain Performance Confirmation program consists of tests, monitoring activities, experiments, and analyses to evaluate the adequacy of assumptions, data, and analyses that form the basis of the conceptual and numerical models of flow and transport associated with a proposed radioactive waste repository at Yucca Mountain, Nevada. The Performance Confirmation program uses an eight-stage risk-informed, performance-based approach. Selection of the Performance Confirmation activities (a parameter and a test method) for inclusion in the Performance Confirmation program was done using a risk-informed performance-based decision analysis. The result of this analysis and review was a Performance Confirmation base portfolio that consists of 20 activities. The 20 Performance Confirmation activities include geologic, hydrologic, and construction/engineering testing. Several of the activities were initiated during site characterization and are ongoing. Others activities will commence during construction and/or post emplacement and will continue until repository closure

  20. Multiple Sclerosis

    Science.gov (United States)

    Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the ... attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins ...

  1. Multiple Endpoints

    OpenAIRE

    Parys, Dariusz

    2007-01-01

    In ANOVA we are mainly based on inter-treatment comparisons. Another common problems arising in biometric studies (especially in biomedical studies) is that of comparing two groups of patients (treatment and a control group) based on multiple response (called multiple endpoints). In this paper we present the continuos and discrete approaches to multiple endpoints. In the case of continuous multiple endpoints we have common assumption in that the covariance matrices in group ...

  2. Artefactual multiplicity

    DEFF Research Database (Denmark)

    Bjørn, Pernille; Hertzum, Morten

    2011-01-01

    Whiteboards are highly important to the work in emergency departments (EDs). As a collaborative technology ED whiteboards are usually placed in the dynamic centre of the ED, and all ED staff will approach the whiteboard regularly to organize their individual yet interdependent work. Currently, di...... this characteristic of heterogeneous artefacts; namely artefactual multiplicity. Artefactual multiplicity identifies not only the multiple functions of heterogeneous artefacts but also the intricate relations between these multiple functionalities....

  3. Finger Multiplication

    Science.gov (United States)

    Simanihuruk, Mudin

    2011-01-01

    Multiplication facts are difficult to teach. Therefore many researchers have put a great deal of effort into finding multiplication strategies. Sherin and Fuson (2005) provided a good survey paper on the multiplication strategies research area. Kolpas (2002), Rendtorff (1908), Dabell (2001), Musser (1966) and Markarian (2009) proposed the finger…

  4. Empirical analyses of the factors affecting confirmation bias and the effects of confirmation bias on software developer/tester performance

    OpenAIRE

    Calikli, Gul; Bener, Ayse

    2010-01-01

    Background: During all levels of software testing, the goal should be to fail the code. However, software developers and testers are more likely to choose positive tests rather than negative ones due to the phenomenon called confirmation bias. Confirmation bias is defined as the tendency of people to verify their hypotheses rather than refuting them. In the literature, there are theories about the possible effects of confirmation bias on software development and testing. Due to the tendency t...

  5. Poliomyelitis in Osun State, Nigeria: Two Confirmed Cases After 6 ...

    African Journals Online (AJOL)

    The Clinico-epidemological characteristics of two confirmed cases of poliomyelitis detected by Acute Flaccid Paralysis (AFP) surveillance in Osun State of Nigeria after almost 6 years of the last confirmed case in the State was reported to provide information for formulating possible aetiological hypothesis and to adequately ...

  6. The role of laboratory confirmations and molecular epidemiology in ...

    African Journals Online (AJOL)

    This review reports on the role of laboratory confirmation and molecular epidemiology in global eradication of measles. The role of laboratory confirmation and molecular epidemiology in defining the origins of measles outbreaks cannot be overemphasized. New serological tests based on recombinant proteins detect only a ...

  7. Multiplicity Counting

    Energy Technology Data Exchange (ETDEWEB)

    Geist, William H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-01

    This set of slides begins by giving background and a review of neutron counting; three attributes of a verification item are discussed: 240Pueff mass; α, the ratio of (α,n) neutrons to spontaneous fission neutrons; and leakage multiplication. It then takes up neutron detector systems – theory & concepts (coincidence counting, moderation, die-away time); detector systems – some important details (deadtime, corrections); introduction to multiplicity counting; multiplicity electronics and example distributions; singles, doubles, and triples from measured multiplicity distributions; and the point model: multiplicity mathematics.

  8. An alternative method to achieve metrological confirmation in measurement process

    Science.gov (United States)

    Villeta, M.; Rubio, E. M.; Sanz, A.; Sevilla, L.

    2012-04-01

    Metrological confirmation process must be designed and implemented to ensure that metrological characteristics of the measurement system meet metrological requirements of the measurement process. The aim of this paper is to present an alternative method to the traditional metrological requirements about the relationship between tolerance and measurement uncertainty, to develop such confirmation processes. The proposed way to metrological confirmation considers a given inspection task of the measurement process into the manufacturing system, and it is based on the Index of Contamination of the Capability, ICC. Metrological confirmation process is then developed taking into account the producer risks and economic considerations on this index. As a consequence, depending on the capability of the manufacturing process, the measurement system will be or will not be in adequate state of metrological confirmation for the measurement process.

  9. MULTIPLE OBJECTS

    Directory of Open Access Journals (Sweden)

    A. A. Bosov

    2015-04-01

    Full Text Available Purpose. The development of complicated techniques of production and management processes, information systems, computer science, applied objects of systems theory and others requires improvement of mathematical methods, new approaches for researches of application systems. And the variety and diversity of subject systems makes necessary the development of a model that generalizes the classical sets and their development – sets of sets. Multiple objects unlike sets are constructed by multiple structures and represented by the structure and content. The aim of the work is the analysis of multiple structures, generating multiple objects, the further development of operations on these objects in application systems. Methodology. To achieve the objectives of the researches, the structure of multiple objects represents as constructive trio, consisting of media, signatures and axiomatic. Multiple object is determined by the structure and content, as well as represented by hybrid superposition, composed of sets, multi-sets, ordered sets (lists and heterogeneous sets (sequences, corteges. Findings. In this paper we study the properties and characteristics of the components of hybrid multiple objects of complex systems, proposed assessments of their complexity, shown the rules of internal and external operations on objects of implementation. We introduce the relation of arbitrary order over multiple objects, we define the description of functions and display on objects of multiple structures. Originality.In this paper we consider the development of multiple structures, generating multiple objects.Practical value. The transition from the abstract to the subject of multiple structures requires the transformation of the system and multiple objects. Transformation involves three successive stages: specification (binding to the domain, interpretation (multiple sites and particularization (goals. The proposed describe systems approach based on hybrid sets

  10. First confirmed record of Elodea canadensis Michx. (Hydrocharitaceae in Greece

    Directory of Open Access Journals (Sweden)

    Poulis Georgios

    2017-12-01

    Full Text Available The paper confirms the presence of Elodea canadensis Michx. in Greece and outlines the history of contradictory relevant reports. This is also the first report of the species′ presence in the transboundary lake Great Prespa.

  11. NIH study confirms risk factors for male breast cancer

    Science.gov (United States)

    Pooled data from studies of about 2,400 men with breast cancer and 52,000 men without breast cancer confirmed that risk factors for male breast cancer include obesity, a rare genetic condition called Klinefelter syndrome, and gynecomastia.

  12. Consumer satisfaction and confirmation of habits of comprehension

    DEFF Research Database (Denmark)

    Sørensen, Bent; Andersen, Christian; Andersen, Morten Purup

    2014-01-01

    The purpose of this article is twofold: First, within a Peircean framework it shall be demonstrated how there is a relation between the compositional structure of certain types of print advertisements and their bringing about inductive comprehension, and how the consumer can be understood...... as a bundle of habits. It is the assumption that advertising that supports an inductive effect particularly appeals to the cognitive tendency of habit formation in the consumer. Second, it is asked whether advertisements that predominantly invite inductive processes of comprehension also influence...... the formation of consumer satisfaction; the perspective is that of the confirmation paradigm within advertisement research. Inductive advertisements support cognitive habit formation through confirmation, and the confirmation paradigm explains exactly consumer satisfaction with reference to confirmation. Hence...

  13. CERN confirms goal of 2007 start-up for LHC

    CERN Multimedia

    2005-01-01

    Speaking at the 131st session of CERN Council on 17 December 2004, the Director-General, Robert Aymar, confirmed that the top priority is to maintain the goal of starting up the Large Hadron Collider (LHC) in 2007.

  14. Scientists confirm delay in testing new CERN particle accelerator

    CERN Multimedia

    2007-01-01

    "Scientists seeking to uncover the secrets of the universe will have to wait a little longer after the CERN laboratory inswitzerland on Monday confirmed a delay in tests of a massive new particle accelerator." (1 page)

  15. Installation Restoration Program. Confirmation/Quantification Stage 1. Phase 2

    Science.gov (United States)

    1985-03-07

    follows: Phase I - Problem Identification/Records Search Phase II - Problem Confirmation/QuantificationI Phase III - Technology Base Development Phase IV...Identification/Records Search 3 Phase II-- Problem Confirmation/Quantification Phase III -- Technology Base Development 3 Phase IV -- Operations...United States Air Force Occupational and Environmental Helth Laboratory 3 VADOSE ZONE: That area below the ground surface and above the water table WATER

  16. Association between stillbirth and risk factors known at pregnancy confirmation.

    Science.gov (United States)

    2011-12-14

    to pregnancy (<10 cigarettes/d, 10.0% stillbirths, 6.5% live births) (vs none; AOR, 1.55 [95% CI, 1.02-2.35]); obesity/overweight (15.5% stillbirths, 12.4% live births) (vs normal weight; AOR, 1.72 [95% CI, 1.22-2.43]); not living with a partner (25.4% stillbirths, 15.3% live births) (vs married; AOR, 1.62 [95% CI, 1.15-2.27]); and plurality (6.4% stillbirths, 1.9% live births) (vs singleton; AOR, 4.59 [95% CI, 2.63-8.00]). The generalized R(2) was 0.19, explaining little of the variance. Multiple risk factors that would have been known at the time of pregnancy confirmation were associated with stillbirth but accounted for only a small amount of the variance in this outcome.

  17. Multiple sclerosis

    International Nuclear Information System (INIS)

    Grunwald, I.Q.; Kuehn, A.L.; Backens, M.; Papanagiotou, P.; Shariat, K.; Kostopoulos, P.

    2008-01-01

    Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI. (orig.) [de

  18. Preliminary Analysis of Remote Monitoring & Robotic Concepts for Performance Confirmation

    Energy Technology Data Exchange (ETDEWEB)

    D.A. McAffee

    1997-02-18

    As defined in 10 CFR Part 60.2, Performance Confirmation is the ''program of tests, experiments and analyses which is conducted to evaluate the accuracy and adequacy of the information used to determine with reasonable assurance that the performance objectives for the period after permanent closure will be met''. The overall Performance Confirmation program begins during site characterization and continues up to repository closure. The main purpose of this document is to develop, explore and analyze initial concepts for using remotely operated and robotic systems in gathering repository performance information during Performance Confirmation. This analysis focuses primarily on possible Performance Confirmation related applications within the emplacement drifts after waste packages have been emplaced (post-emplacement) and before permanent closure of the repository (preclosure). This will be a period of time lasting approximately 100 years and basically coincides with the Caretaker phase of the project. This analysis also examines, to a lesser extent, some applications related to Caretaker operations. A previous report examined remote handling and robotic technologies that could be employed during the waste package emplacement phase of the project (Reference 5.1). This analysis is being prepared to provide an early investigation of possible design concepts and technical challenges associated with developing remote systems for monitoring and inspecting activities during Performance Confirmation. The writing of this analysis preceded formal development of Performance Confirmation functional requirements and program plans and therefore examines, in part, the fundamental Performance Confirmation monitoring needs and operating conditions. The scope and primary objectives of this analysis are to: (1) Describe the operating environment and conditions expected in the emplacement drifts during the preclosure period. (Presented in Section 7.2). (2

  19. Eric Besson: the financial advantage of nuclear energy is confirmed

    International Nuclear Information System (INIS)

    Anon.

    2012-01-01

    The French minister of energy, E. Besson said that the study of the Court of Auditors on the real costs of nuclear energy confirmed the competitiveness of nuclear power. The Court of Auditors confirmed also that public expenditures in favor of nuclear energy are balanced by the gain through the tax on nuclear facilities. The Court of Auditors confirms also that dismantlement charges and charges for the management of radioactive wastes are included in the present costs of nuclear energy at an adequate level with today's knowledge. The total cost of nuclear energy is very competitive, it ranges form 32.5 euros/MWh to 49.5 euros/MWh according to the cost accounting method used. One of major parameters for cost elaboration is the knowledge of the lengths of the operating life of the power plant. The longer the extension is, the lower is the investment cost. (A.C.)

  20. Racial athletic stereotype confirmation in college football recruiting.

    Science.gov (United States)

    Thomas, Grant; Good, Jessica J; Gross, Alexi R

    2015-01-01

    The present study tested real-world racial stereotype use in the context of college athletic recruiting. Stereotype confirmation suggests that observers use stereotypes as hypotheses and interpret relevant evidence in a biased way that confirms their stereotypes. Shifting standards suggest that the evaluative standard to which we hold a target changes as a function of their group membership. We examined whether stereotype confirmation and shifting standards effects would be seen in college football coaches during recruiting. College football coaches evaluated a Black or White player on several attributes and made both zero- and non-zero-sum allocations. Results suggested that coaches used the evidence presented to develop biased subjective evaluations of the players based on race while still maintaining equivalent objective evaluations. Coaches also allocated greater overall resources to the Black recruit than the White recruit.

  1. Multiple myeloma.

    LENUS (Irish Health Repository)

    Collins, Conor D

    2012-02-01

    Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. This article summarises the current status and highlights how an understanding of both is necessary for optimum management.

  2. Multiple Sclerosis

    Science.gov (United States)

    ... read or download the National Academies/Institute of Medicine report, go to: " Multiple Sclerosis: Current Status and Strategies for the Future ." Information from the National Library of Medicine’s MedlinePlus ...

  3. Short communications: The first confirmed breeding record and new ...

    African Journals Online (AJOL)

    Short communications: The first confirmed breeding record and new distribution data for Böhm's Flycatcher Myopornis boehmi in Tanzania. N E Baker, G A Mbilinyi. Abstract. No abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals ...

  4. 18 CFR 300.10 - Application for confirmation and approval.

    Science.gov (United States)

    2010-04-01

    ... REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS FOR FEDERAL POWER MARKETING ADMINISTRATIONS CONFIRMATION AND APPROVAL OF THE RATES OF FEDERAL POWER MARKETING ADMINISTRATIONS Filing Requirements § 300.10... with applicable laws and that it is the lowest possible rate consistent with sound business principles...

  5. Detection and confirmation of toxigenic Vibrio cholerae O1 in ...

    African Journals Online (AJOL)

    2013-08-20

    Aug 20, 2013 ... PCR template. Therefore, the multiplex PCR assay described herein is a quick, sensitive and effective method for monitoring of V. cholerae in the environment as well as for confirmation of its toxigenicity and epidemic potential. CONCLUSION. Toxigenic Vibrio cholerae O1 is the major causative agent of.

  6. Narrative Skills Following Early Confirmation of Permanent Childhood Hearing Impairment

    Science.gov (United States)

    Worsfold, Sarah; Mahon, Merle; Yuen, Ho Ming; Kennedy, Colin

    2010-01-01

    Aim: The aim of this study was to compare spoken language production in children with permanent childhood hearing impairment (PCHI) whose PCHI was confirmed either early or late. Method: Audio-taped spoken narrative was assessed for syntax, phonology, morphology, and narrative in transcripts from a population-based sample of 89 children (49 males,…

  7. Confirmation of the absolute configuration of (−)-aurantioclavine

    KAUST Repository

    Behenna, Douglas C.

    2011-04-01

    We confirm our previous assignment of the absolute configuration of (-)-aurantioclavine as 7R by crystallographically characterizing an advanced 3-bromoindole intermediate reported in our previous synthesis. This analysis also provides additional support for our model of enantioinduction in the palladium(II)-catalyzed oxidative kinetic resolution of secondary alcohols. © 2010 Elsevier Ltd. All rights reserved.

  8. The Nigerian employee and the quest for confirmation: examining ...

    African Journals Online (AJOL)

    Nigeria today, in both private and public establishments, probation is a common employment practice used to ascertain the competence and suitability of employees for confirmation of employment. Hence, this paper through desk base research methodology examines the concept of probationary employment in the light of ...

  9. Confirmation of quantitative trait loci affecting fatness in chickens

    NARCIS (Netherlands)

    Jennen, D.G.J.; Vereijken, A.L.J.; Bovenhuis, H.; Crooijmans, R.P.M.A.; Poel, van der J.J.; Groenen, M.A.M.

    2005-01-01

    In this report we describe the analysis of an advanced intercross line (AIL) to confirm the quantitative trait locus (QTL) regions found for fatness traits in a previous study. QTL analysis was performed on chromosomes 1, 3, 4, 15, 18, and 27. The AIL was created by random intercrossing in each

  10. Laboratory-confirmed Congenital Rubella Syndrome at the ...

    African Journals Online (AJOL)

    Esem

    ORIGINAL ARTICLE. Laboratory-confirmed Congenital Rubella Syndrome at the University Teaching Hospital in Lusaka,. Zambia-Case Reports. 1,2. 3. 3. 4 ... microcephaly. Rubella Immunoglobulin M (IgM) results were positive. The third case, a girl, was seen at twelve weeks and brought in for slow growth rate. On.

  11. Evaluation of histologically confirmed carcinoma of the cervix in ...

    African Journals Online (AJOL)

    Data collected was analysed with SPSS version 20.0 software and presented in tables and charts. Results: Sixty two patients with histological confirmation of ... The commonest histological type of cervical cancer was squamous cell carcinoma accounting for 88.9%. Twenty (44.4%) patients were referred for radiotherapy and ...

  12. Does suggestive information cause a confirmation bias in bullet comparisons?

    NARCIS (Netherlands)

    Kerstholt, J.H.; Eikelboom, A.; Dijkman, T.; Stoel, R.; Hermsen, R.; Leuven, B. van

    2010-01-01

    Several researchers have argued that the confirmation bias, the tendency to selectively gather and process information such that it fits existing beliefs, is a main threat to objective forensic examinations. The goal of the present study was to empirically investigate whether examiners making bullet

  13. Factors associated with child sexual abuse confirmation at forensic examinations

    Directory of Open Access Journals (Sweden)

    Welington dos Santos Silva

    Full Text Available Abstract The aim of this study is identify potential factors associated with child sexual abuse confirmation at forensic examinations. The forensic files of children under 12 years of age reporting sexual abuse at the Nina Rodrigues Institute of Forensic Medicine in Salvador, Bahia, Brazil between January 2008 and December 2009 were reviewed. A multivariate analysis was conducted to identify factors associated with finding evidence of sexual abuse in forensic examinations. The proportion of cases confirmed by the forensic physician based on material evidence was 10.4%. Adjusted analysis showed that the variables place of birth, type of abuse reported, family relationship between the child and the perpetrator, and the interval between the reported abuse and the forensic examination were not independently associated with finding forensic evidence of sexual abuse. A report of penetration was associated with a five-fold greater likelihood of confirmation, while the victim being 10-11 years of age was associated with a two-fold of abuse confirmation than younger children. These findings should be taken into consideration when drawing up guidelines for the multidisciplinary evaluation of children suspected of being victims of sexual abuse and in deciding whether to refer the child for forensic examination.

  14. Pathologically confirmed breast cancer in Malawi: a descriptive study

    African Journals Online (AJOL)

    2015-03-12

    Mar 12, 2015 ... Fibroadenoma made up 87% of the benign breast diagnoses. Women without cancer were younger than those with cancer (median age 24 vs 46 years, p < 0.001).Characteristics of the 85 confirmed breast cancer cases are displayed in Table 2. Fifty-five percent of cases occurred in women < 50 years old.

  15. Confirmation of antibodies against L-tryptophan-like epitope in ...

    African Journals Online (AJOL)

    Confirmation of antibodies against L-tryptophan-like epitope in human African trypanosomosis serological diagnostic. ... number of patients in Congo. A diagnostic test based on this synthetic epitope, especially in combination with other tests, might improve the HAT diagnostic test in field conditions. Key words: Tryptophan ...

  16. Laboratory confirmation of rubella infection in suspected measles cases.

    Science.gov (United States)

    Vaidya, Sunil R; Raut, Chandrashekhar G; Jadhav, Santoshkumar M

    2016-10-01

    As a part of measles outbreak based surveillance undertaken by the World Health Organization India, suspected measles cases were referred for the laboratory diagnosis at National Institute of Virology (NIV) Pune and NIV Unit Bengaluru. Altogether, 4,592 serum samples were referred during 2010-2015 from the States of Karnataka (n = 1,173), Kerala (n = 559), and Maharashtra (n = 2,860). Initially, serum samples were tested in measles IgM antibody EIA and samples with measles negative and equivocal results (n = 1,954) were subjected to rubella IgM antibody detection. Overall, 62.9% (2,889/4,592) samples were laboratory confirmed measles, 27.7% (542/1,954) were laboratory confirmed rubella and remaining 25.2% (1,161/4,592) were negative for measles and rubella. The measles vaccination status was available for 1,206 cases. Among the vaccinated individuals, 50.7% (612/1,206) were laboratory confirmed measles. The contribution of laboratory confirmed measles was 493 (40.8%) from Maharashtra, 90 (7.5%) from Karnataka, and 29 (2.4%) from Kerala. Since, 1/3rd of suspected measles cases were laboratory confirmed rubella, an urgent attention needed to build rubella surveillance in India. Additional efforts are required to rule out other exanthematous disease including Dengue and Chikungunya in measles and rubella negatives. J. Med. Virol. 88:1685-1689, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  17. Case report 383: Multiple myeloma

    International Nuclear Information System (INIS)

    Kouwenberg, J.J.; Simons, A.J.

    1986-01-01

    A unique and obviously extremely rare example of multiple myeloma has been presented, affecting the peripheral appendicular skeleton and not the hematopoietic system of the axial skeleton, radiologically and probably pathologically. Only one other similar case has been described. The radiological features were confirmed by the pathological studies: a biopsy specimen obtained from a large osteolytic lesion in a patella showed the typical stigma of multiple myeloma; a biopsy from the iliac creast showed no abnormality. (orig./SHA)

  18. Case report 383: Multiple myeloma

    Energy Technology Data Exchange (ETDEWEB)

    Kouwenberg, J.J.; Simons, A.J.

    1986-08-01

    A unique and obviously extremely rare example of multiple myeloma has been presented, affecting the peripheral appendicular skeleton and not the hematopoietic system of the axial skeleton, radiologically and probably pathologically. Only one other similar case has been described. The radiological features were confirmed by the pathological studies: a biopsy specimen obtained from a large osteolytic lesion in a patella showed the typical stigma of multiple myeloma; a biopsy from the iliac creast showed no abnormality. (orig./SHA).

  19. Histopathology confirms white-nose syndrome in bats in Europe

    Science.gov (United States)

    Pikula, J.; Bandouchova, H.; Novotny, L.; Meteyer, C.U.; Zukal, J.; Irwin, N.R.; Zima, J.; Martinkova, N.

    2012-01-01

    White-nose syndrome, associated with the fungal skin infection geomycosis, caused regional population collapse in bats in North America. Our results, based on histopathology, show the presence of white-nose syndrome in Europe. Dermatohistopathology on two bats (Myotis myotis) found dead in March 2010 with geomycosis in the Czech Republic had characteristics resembling Geomyces destructans infection in bats confirmed with white-nose syndrome in US hibernacula. In addition, a live M. myotis, biopsied for histopathology during hibernation in April 2011, had typical fungal infection with cupping erosion and invasion of muzzle skin diagnostic for white-nose syndrome and conidiospores identical to G. destructans that were genetically confirmed as G. destructans. ?? Wildlife Disease Association 2012.

  20. Caldwell Ranch Exploration and Confirmation Project, Northwest Geysers, CA

    Energy Technology Data Exchange (ETDEWEB)

    Walters, Mark A.

    2013-04-25

    The purpose of the Caldwell Ranch Exploration and Confirmation Project was to drill, test, and confirm the present economic viability of the undeveloped geothermal reservoir in the 870 acre Caldwell Ranch area of the Northwest Geysers that included the CCPA No.1 steam field. All of the drilling, logging, and sampling challenges were met. Three abandoned wells, Prati 5, Prati 14 and Prati 38 were re-opened and recompleted to nominal depths of 10,000 feet in 2010. Two of the wells required sidetracking. The flow tests indicated Prati 5 Sidetrack 1 (P-5 St1), Prati 14 (P-14) and Prati 38 Sidetrack 2 (P-38 St2) were collectively capable of initially producing an equivalent of 12 megawatts (MWe) of steam using a conversion rate of 19,000 pounds of steam/hour

  1. Molecular confirmation of Lassa fever imported into Ghana

    Directory of Open Access Journals (Sweden)

    Joseph H.K. Bonney

    2016-04-01

    Objective: We report the results of these investigations to highlight the importance of molecular diagnostic applications and the need for heightened awareness about Lassa fever in West Africa. Methods: We used molecular assays on sera from the two patients to identify the causativeorganism. Upon detection of positive signals for Lassa virus ribonucleic material by two differentpolymerase chain reaction assays, sequencing and phylogenetic analyses were performed. Results: The presence of Lassa virus in the soldiers’ blood samples was shown by L-gene segment homology to be the Macenta and las803792 strains previously isolated in Liberia, with close relationships then confirmed by phylogenetic tree construction. The five asymptomatic close contacts were negative for Lassa virus. Conclusions: The Lassa virus strains identified in the two Ghanaian soldiers had molecular epidemiological links to strains from Liberia. Lassa virus was probably responsible for the outbreak of viral haemorrhagic fever in the military camp. These data confirm Lassa fever endemicity in West Africa.

  2. Confirming the Lanchestrian linear-logarithmic model of attrition

    Energy Technology Data Exchange (ETDEWEB)

    Hartley, D.S. III.

    1990-12-01

    This paper is the fourth in a series of reports on the breakthrough research in historical validation of attrition in conflict. Significant defense policy decisions, including weapons acquisition and arms reduction, are based in part on models of conflict. Most of these models are driven by their attrition algorithms, usually forms of the Lanchester square and linear laws. None of these algorithms have been validated. The results of this paper confirm the results of earlier papers, using a large database of historical results. The homogeneous linear-logarithmic Lanchestrian attrition model is validated to the extent possible with current initial and final force size data and is consistent with the Iwo Jima data. A particular differential linear-logarithmic model is described that fits the data very well. A version of Helmbold's victory predicting parameter is also confirmed, with an associated probability function. 37 refs., 73 figs., 68 tabs.

  3. Theory of chaotic orbital variations confirmed by Cretaceous geological evidence

    Science.gov (United States)

    Ma, Chao; Meyers, Stephen R.; Sageman, Bradley B.

    2017-02-01

    Variations in the Earth’s orbit and spin vector are a primary control on insolation and climate; their recognition in the geological record has revolutionized our understanding of palaeoclimate dynamics, and has catalysed improvements in the accuracy and precision of the geological timescale. Yet the secular evolution of the planetary orbits beyond 50 million years ago remains highly uncertain, and the chaotic dynamical nature of the Solar System predicted by theoretical models has yet to be rigorously confirmed by well constrained (radioisotopically calibrated and anchored) geological data. Here we present geological evidence for a chaotic resonance transition associated with interactions between the orbits of Mars and the Earth, using an integrated radioisotopic and astronomical timescale from the Cretaceous Western Interior Basin of what is now North America. This analysis confirms the predicted chaotic dynamical behaviour of the Solar System, and provides a constraint for refining numerical solutions for insolation, which will enable a more precise and accurate geological timescale to be produced.

  4. Nasogastric tubes. 1: Insertion technique and confirming the correct position.

    Science.gov (United States)

    Durai, Rajaraman; Venkatraman, Ramya; Ng, Philip C H

    This is the first in a two-part unit on nasogastric tube management. It discusses the indications, patient preparation, insertion technique and various methods of confirming the tube's position. According to the National Patient Safety Agency, 11 deaths and one case of serious harm occurred due to misplaced nasogastric feeding tubes over a two-year period. It is therefore vital for staff inserting these tubes to know both the correct insertion methods and the procedure for verifying their correct intragastric positioning.

  5. Assessment of Response Surface Models using Independent Confirmation Point Analysis

    Science.gov (United States)

    DeLoach, Richard

    2010-01-01

    This paper highlights various advantages that confirmation-point residuals have over conventional model design-point residuals in assessing the adequacy of a response surface model fitted by regression techniques to a sample of experimental data. Particular advantages are highlighted for the case of design matrices that may be ill-conditioned for a given sample of data. The impact of both aleatory and epistemological uncertainty in response model adequacy assessments is considered.

  6. The IN SITU PRACLAY demonstration and confirmation experiments

    International Nuclear Information System (INIS)

    Bernier, F.; Li, X.L.; Verstricht, J.; Bastiaens, W.

    2008-01-01

    The PRACLAY Demonstration and Confirmation Experiments consist in the experimental work and the supporting studies related to the characterisation, the verification, the confirmation and the demonstration of relevant elements of the disposal system for vitrified heat emitting waste in Boom Clay. The programme includes surface and in situ large scale experiments. At this time the PRACLAY Demonstration and Confirmation Experiments are divided in two main parts: PRACLAY IN SITU and PRACLAY SURFACE. This paper describes the achievements and the future works of the IN SITU part of the programme. The achievements are the demonstration of the construction of shafts and galleries at industrial scale and the characterisation of the hydro-mechanical response of the host rock. Many geotechnical measurements have been performed around excavations. Comparison between in-situ measurements and modelling results allowed a continuous improvement of our knowledge on the Boom Clay behaviour. The future works will consist mainly in the realisation of the 'PRACLAY Heater Experiment' a large scale heater test. For this purpose, a blind gallery about 45 m long will be excavated using a tunneling machine. The diameter will be 2.5 m. The design study of the experiment pointed out the importance of the hydromechanical conditions prevailing during the thermal phase. (authors)

  7. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, Egon; Stenager, E N; Knudsen, Lone

    1994-01-01

    In a cross-sectional study of 117 randomly selected patients (52 men, 65 women) with definite multiple sclerosis, it was found that 76 percent were married or cohabitant, 8 percent divorced. Social contacts remained unchanged for 70 percent, but outgoing social contacts were reduced for 45 percent......, need for structural changes in home and need for pension became greater with increasing physical handicap. No significant differences between gender were found. It is concluded that patients and relatives are under increased social strain, when multiple sclerosis progresses to a moderate handicap...

  8. Pu(VI) nitrate crystallization behavior confirmation experiment

    International Nuclear Information System (INIS)

    Yano, Hajime; Nishimura, Kenji; Chikazawa, Takahiro; Teramae, Naoki

    2001-03-01

    Crystallization procedure is considered to have an advantage in recovering rather pure uranium from contaminated uranium solution and to be applicable for a new reprocessing process. It is considered necessary to collect data for Pu crystallization for design of the process with crystallization procedure. Last year the test for Pu(IV) nitrate crystallization was performed and it was confirmed that Pu crystallization is not observed under supposed crystallization condition if Pu valence is adjusted to 4. In this study, two type beaker tests were performed, 1. Pu(VI) nitrate crystallization test to confirm a behavior of Pu(VI) nitrate under crystallization condition. 2. U-Pu(VI) nitrate crystallization test to confirm a U-Pu(VI) co-crystallization phenomena. These tests were performed in AEA Technology Harwell Laboratory and the results were examined by Mitsubishi Materials Corporation. Test results were as follows. (1) Pu(VI) crystallization test. 1. Pu(VI) nitrate solution of 200,100 and 50 gPu/L with HNO 3 6M were cooled down up to -60degC to confirm Pu(VI) nitrate crystallization or freezing of the solution. 2. Crystal of H 2 O and HNO 3 · 3 H 2 O were observed but Pu(VI) nitrate crystallization was not observed. 3. We can estimate that Pu(VI) nitrate crystallization will not occurred in the reprocessing process with crystallization procedure. (2) U-Pu(VI) nitrate crystallization test. 1. U-Pu(VI) mixed nitrate solution is cooled to 10degC and 0degC. 2. U-Pu(VI) co-crystallization was confirmed by orange colored crystal in both cooling temperatures. 3. It is considered that Pu(VI) nitrate crystal is co-crystallized with uranyl nitrate crystal by the following reasons. chemical formula of both crystal are similar. crystal form is same and lattice parameters are very near. 4. U+Pu(VI) crystallization data is very near with uranyl nitrate crystallization data if Pu(VI) nitrate is considered to be crystallized in a same manner as uranyl nitrate. (author)

  9. Confirmation of right whales near a nineteenth-century whaling ground east of southern Greenland.

    Science.gov (United States)

    Mellinger, David K; Nieukirk, Sharon L; Klinck, Karolin; Klinck, Holger; Dziak, Robert P; Clapham, Phillip J; Brandsdóttir, Bryndís

    2011-06-23

    North Atlantic right whales (Eubalaena glacialis) were found in an important nineteenth century whaling area east of southern Greenland, from which they were once thought to have been extirpated. In 2007-2008, a 1-year passive acoustic survey was conducted at five sites in and near the 'Cape Farewell Ground', the former whaling ground. Over 2000 right whale calls were recorded at these sites, primarily during July-November. Most calls were northwest of the historic ground, suggesting a broader range in this region than previously known. Geographical and temporal separation of calls confirms use of this area by multiple animals.

  10. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E; Knudsen, L; Jensen, K

    1991-01-01

    In a cross-sectional investigation of 116 patients with multiple sclerosis, the social and sparetime activities of the patient were assessed by both patient and his/her family. The assessments were correlated to physical disability which showed that particularly those who were moderately disabled...

  11. Multiple Myeloma

    African Journals Online (AJOL)

    The results of the use of melphalan in 52 patients with multiple myeloma have been analysed. The median survival of the whole group of patients was 30 months, and of those w:th renal insufficiency only 12,5 months. Bence-lones proteinuria was also a poor prognostic finding,. but only because of its association with renal ...

  12. Multiple Sclerosis.

    Science.gov (United States)

    Plummer, Nancy; Michael, Nancy, Ed.

    This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

  13. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E; Jensen, K

    1988-01-01

    Forty-two (12%) of a total of 366 patients with multiple sclerosis (MS) had psychiatric admissions. Of these, 34 (81%) had their first psychiatric admission in conjunction with or after the onset of MS. Classification by psychiatric diagnosis showed that there was a significant positive correlati...

  14. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E; Jensen, K

    1990-01-01

    An investigation on the correlation between ability to read TV subtitles and the duration of visual evoked potential (VEP) latency in 14 patients with definite multiple sclerosis (MS), indicated that VEP latency in patients unable to read the TV subtitles was significantly delayed in comparison...

  15. Confirmation test of powder mixing process in J-MOX

    International Nuclear Information System (INIS)

    Ota, Hiroshi; Osaka, Shuichi; Kurita, Ichiro

    2009-01-01

    Japan Nuclear Fuel Ltd. (hereafter, JNFL) MOX Fuel Fabrication Plant (hereafter, J-MOX) is what fabricates MOX fuel for domestic light water power plants. Development of design concept of J-MOX was started mid 90's and the frame of J-MOX process was clarified around 2000 including adoption of MIMAS process as apart of J-MOX powder process. JNFL requires to take an answer to any technical question that has not been clarified ever before by world's MOX and/or Uranium fabricators before it commissions equipment procurement. J-MOX is to be constructed adjacent to the Rokkasho Reprocessing Plant (RRP) and to utilize MH-MOX powder recovered at RRP. The combination of the MIMAS process and the MH-MOX powder is what has never tried in the world. Therefore JNFL started a series of confirmation tests of which the most important is the powder test to confirm the applicability of MH-MOX powder to the MIMAS process. The MH-MOX powder, consisting of 50% plutonium oxide and 50% uranium oxide, originates JAEA development utilizing microwave heating (MH) technology. The powder test started with laboratory scale small equipment utilizing both uranium and the MOX powder in 2000, left a solution to tough problem such as powder adhesion onto equipment, and then was followed by a large scale equipment test again with uranium and the MOX powder. For the MOX test, actual size equipment within glovebox was manufactured and installed in JAEA plutonium fuel center in 2005, and based on results taken so far an understanding that the MIMAS equipment, with the MH-MOX powder, can present almost same quality MOX pellet as what is introduced as fabricated in Europe was developed. The test was finished at the end of Japanese fiscal year (JFY) 2007, and it was confirmed that the MOX pellets fabricated in this test were almost satisfied with the targeted specifications set for domestic LWR MOX fuels. (author)

  16. Objective confirmation of asthma diagnosis improves medication adherence

    DEFF Research Database (Denmark)

    Backer, V; Stensen, L; Sverrild, A

    2017-01-01

    OBJECTIVE: The impact of diagnostic work-up in asthma management on medication redemption and probably also drug adherence is largely unknown, but we hypothesized that a confirmed diagnosis of asthma in a hospital-based out-patient clinic increases the willingness to subsequent medication...... redemption in a real life setting. METHODS: In a retrospective register-based study, 300 medical records of patients referred with possible asthma during one year were examined, of whom 171 had asthma (57%). One-year data on dispensed medicine was collected using the Danish Registry of Medicinal Product...

  17. Analytical approach for confirming the achievement of LMFBR reliability goals

    International Nuclear Information System (INIS)

    Ingram, G.E.; Elerath, J.G.; Wood, A.P.

    1981-01-01

    The approach, recommended by GE-ARSD, for confirming the achievement of LMFBR reliability goals relies upon a comprehensive understanding of the physical and operational characteristics of the system and the environments to which the system will be subjected during its operational life. This kind of understanding is required for an approach based on system hardware testing or analyses, as recommended in this report. However, for a system as complex and expensive as the LMFBR, an approach which relies primarily on system hardware testing would be prohibitive both in cost and time to obtain the required system reliability test information. By using an analytical approach, results of tests (reliability and functional) at a low level within the specific system of interest, as well as results from other similar systems can be used to form the data base for confirming the achievement of the system reliability goals. This data, along with information relating to the design characteristics and operating environments of the specific system, will be used in the assessment of the system's reliability

  18. Structural confirmation of oligosaccharides newly isolated from sugar beet molasses

    Directory of Open Access Journals (Sweden)

    Abe Tatsuya

    2012-08-01

    Full Text Available Abstract Background Sugar beet molasses is a viscous by-product of the processing of sugar beets into sugar. The molasses is known to contain sucrose and raffinose, a typical trisaccharide, with a well-established structure. Although sugar beet molasses contains various other oligosaccharides as well, the structures of those oligosaccharides have not been examined in detail. The purpose of this study was isolation and structural confirmation of these other oligosaccharides found in sugar beet molasses. Results Four oligosaccharides were newly isolated from sugar beet molasses using high-performance liquid chromatography (HPLC and carbon-Celite column chromatography. Structural confirmation of the saccharides was provided by methylation analysis, matrix-assisted laser desorption/ionaization time of flight mass spectrometry (MALDI-TOF-MS, and nuclear magnetic resonance (NMR measurements. Conclusion The following oligosaccharides were identified in sugar beet molasses: β-D-galactopyranosyl-(1- > 6-β-D-fructofuranosyl-(2 1-α-D-glucopyranoside (named β-planteose, α-D-galactopyranosyl-(1- > 1-β-D-fructofuranosyl-(2 1-α-D-glucopyranoside (named1-planteose, α-D-glucopyranosyl-(1- > 6-α-D-glucopyranosyl-(1 2-β-D-fructofuranoside (theanderose, and β-D-glucopyranosyl-(1- > 3-α-D-glucopyranosyl-(1 2-β-D-fructofuranoside (laminaribiofructose. 1-planteose and laminaribiofructose were isolated from natural sources for the first time.

  19. Molecular confirmation of Lassa fever imported into Ghana.

    Science.gov (United States)

    Bonney, Joseph H K; Nyarko, Edward O; Ohene, Sally-Ann; Amankwa, Joseph; Ametepi, Ralph K; Nimo-Paintsil, Shirley C; Sarkodie, Badu; Agbenohevi, Prince; Adjabeng, Michael; Kyei, Nicholas N A; Bel-Nono, Samuel; Ampofo, William K

    2016-01-01

    Recent reports have shown an expansion of Lassa virus from the area where it was first isolated in Nigeria to other areas of West Africa. Two Ghanaian soldiers on a United Nations peacekeeping mission in Liberia were taken ill with viral haemorrhagic fever syndrome following the death of a sick colleague and were referred to a military hospital in Accra, Ghana, in May 2013. Blood samples from the soldiers and five asymptomatic close contacts were subjected to laboratory investigations. We report the results of these investigations to highlight the importance of molecular diagnostic applications and the need for heightened awareness about Lassa fever in West Africa. We used molecular assays on sera from the two patients to identify the causative organism. Upon detection of positive signals for Lassa virus ribonucleic material by two different polymerase chain reaction assays, sequencing and phylogenetic analyses were performed. The presence of Lassa virus in the soldiers' blood samples was shown by L-gene segment homology to be the Macenta and las803792 strains previously isolated in Liberia, with close relationships then confirmed by phylogenetic tree construction. The five asymptomatic close contacts were negative for Lassa virus. The Lassa virus strains identified in the two Ghanaian soldiers had molecular epidemiological links to strains from Liberia. Lassa virus was probably responsible for the outbreak of viral haemorrhagic fever in the military camp. These data confirm Lassa fever endemicity in West Africa.

  20. Meeting Weight Management Goals: The Role of Partner Confirmation.

    Science.gov (United States)

    Dailey, René M; Crook, Brittani; Glowacki, Elizabeth; Prenger, Erica; Winslow, Addie Anderson

    2016-12-01

    Social support research suggests romantic partners could play a vital role in the success of individuals' weight management (WM) efforts, but contradictory findings from previous research have impeded our understanding of how romantic partners influence weight management goal attainment. Employing a confirmation perspective, overweight participants (body mass index [BMI] greater than 25) who were actively trying to manage their weight (N = 53) were asked to respond to daily questionnaires for a period of 2 weeks regarding their interactions with their romantic partner. Diet, exercise, and general weight management goal accomplishment were assessed. HLM was employed to assess the independent and interactive effects of partner acceptance and challenge on each of these goals. Findings suggest that perceiving high levels of both acceptance and challenge from partners was associated with more general WM and diet goal accomplishment. However, greater attainment of exercise goals was associated with only challenge. Fluctuations in partner acceptance and challenge were also examined to determine whether consistency in confirmation behaviors was associated with WM goals. Hierarchical regressions revealed that fluctuations in acceptance, but not challenge, were linked with goal attainment. Specifically, fluctuations in acceptance were helpful for those whose partners were perceived to exhibit lower levels of acceptance, but fluctuations were detrimental for those whose partners exhibited greater acceptance. Implications for communication among couples in which one partner is attempting to lose weight are discussed.

  1. Catapult current sheet relaxation model confirmed by THEMIS observations

    Science.gov (United States)

    Machida, S.; Miyashita, Y.; Ieda, A.; Nose, M.; Angelopoulos, V.; McFadden, J. P.

    2014-12-01

    In this study, we show the result of superposed epoch analysis on the THEMIS probe data during the period from November, 2007 to April, 2009 by setting the origin of time axis to the substorm onset determined by Nishimura with THEMIS all sky imager (THEMS/ASI) data (http://www.atmos.ucla.edu/~toshi/files/paper/Toshi_THEMIS_GBO_list_distribution.xls). We confirmed the presence of earthward flows which can be associated with north-south auroral streamers during the substorm growth phase. At around X = -12 Earth radii (Re), the northward magnetic field and its elevation angle decreased markedly approximately 4 min before substorm onset. A northward magnetic-field increase associated with pre-onset earthward flows was found at around X = -17Re. This variation indicates the occurrence of the local depolarization. Interestingly, in the region earthwards of X = -18Re, earthward flows in the central plasma sheet (CPS) reduced significantly about 3min before substorm onset. However, the earthward flows enhanced again at t = -60 sec in the region around X = -14 Re, and they moved toward the Earth. At t = 0, the dipolarization of the magnetic field started at X ~ -10 Re, and simultaneously the magnetic reconnection started at X ~ -20 Re. Synthesizing these results, we can confirm the validity of our catapult current sheet relaxation model.

  2. Use of urinary pregnanediol 3-glucuronide to confirm ovulation.

    Science.gov (United States)

    Ecochard, R; Leiva, R; Bouchard, T; Boehringer, H; Direito, A; Mariani, A; Fehring, R

    2013-10-01

    Urinary hormonal markers may assist in increasing the efficacy of Fertility Awareness Based Methods (FABM). This study uses urinary pregnanediol-3a-glucuronide (PDG) testing to more accurately identify the infertile phase of the menstrual cycle in the setting of FABM. Secondary analysis of an observational and simulation study, multicentre, European study. The study includes 107 women and tracks daily first morning urine (FMU), observed the changes in cervical mucus discharge, and ultrasonography to identify the day of ovulation over 326 menstrual cycles. The following three scenarios were tested: (A) use of the daily pregnandiol-3a-glucuronide (PDG) test alone; (B) use of the PDG test after the first positive urine luteinizing hormone (LH) kit result; (C) use of the PDG test after the disappearance of fertile type mucus. Two models were used: (1) one day of PDG positivity; or (2) waiting for three days of PDG positivity before declaring infertility. After the first positivity of a LH test or the end of fertile mucus, three consecutive days of PDG testing over a threshold of 5μg/mL resulted in a 100% specificity for ovulation confirmation. They were respectively associated an identification of an average of 6.1 and 7.6 recognized infertile days. The results demonstrate a clinical scenario with 100% specificity for ovulation confirmation and provide the theoretical background for a future development of a competitive lateral flow assay for the detection of PDG in the urine. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Confirmation of quantitative trait loci affecting fatness in chickens

    Directory of Open Access Journals (Sweden)

    Poel Jan

    2005-03-01

    Full Text Available Abstract In this report we describe the analysis of an advanced intercross line (AIL to confirm the quantitative trait locus (QTL regions found for fatness traits in a previous study. QTL analysis was performed on chromosomes 1, 3, 4, 15, 18, and 27. The AIL was created by random intercrossing in each generation from generation 2 (G2 onwards until generation 9 (G9 was reached. QTL for abdominal fat weight (AFW and/or percentage abdominal fat (AF% on chromosomes 1, 3 and 27 were confirmed in the G9 population. In addition, evidence for QTL for body weight at the age of 5 (BW5 and 7 (BW7 weeks and for the percentage of intramuscular fat (IF% were found on chromosomes 1, 3, 15, and 27. Significant evidence for QTL was detected on chromosome 1 for BW5 and BW7. Suggestive evidence was found on chromosome 1 for AFW, AF% and IF%, on chromosome 15 for BW5, and on chromosome 27 for AF% and IF%. Furthermore, evidence on the chromosome-wise level was found on chromosome 3 for AFW, AF%, and BW7 and on chromosome 27 for BW5. For chromosomes 4 and 18, test statistics did not exceed the significance threshold.

  4. Multiple Parenting

    OpenAIRE

    Dias, Paulo Cezar; Gramstrup, Erik Frederico

    2016-01-01

    With the modification of the family concept in human history, now considered the site of important value, aimed at personal fulfillment of its members, in line with the Federal Constitution of 1988 was enshrined in the principles of human dignity, affection, equal affiliations and plurality of family entities, recognizing the socio-affective parenting, founded in the state of emotional child, and biological, originally from consanguinity ties, arises multiple parenting in response to the full...

  5. Multiple sclerosis.

    Science.gov (United States)

    Thompson, Alan J; Baranzini, Sergio E; Geurts, Jeroen; Hemmer, Bernhard; Ciccarelli, Olga

    2018-03-22

    Multiple sclerosis continues to be a challenging and disabling condition but there is now greater understanding of the underlying genetic and environmental factors that drive the condition, including low vitamin D levels, cigarette smoking, and obesity. Early and accurate diagnosis is crucial and is supported by diagnostic criteria, incorporating imaging and spinal fluid abnormalities for those presenting with a clinically isolated syndrome. Importantly, there is an extensive therapeutic armamentarium, both oral and by infusion, for those with the relapsing remitting form of the disease. Careful consideration is required when choosing the correct treatment, balancing the side-effect profile with efficacy and escalating as clinically appropriate. This move towards more personalised medicine is supported by a clinical guideline published in 2018. Finally, a comprehensive management programme is strongly recommended for all patients with multiple sclerosis, enhancing health-related quality of life through advocating wellness, addressing aggravating factors, and managing comorbidities. The greatest remaining challenge for multiple sclerosis is the development of treatments incorporating neuroprotection and remyelination to treat and ultimately prevent the disabling, progressive forms of the condition. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Multiple sclerosis

    International Nuclear Information System (INIS)

    Sadashima, Hiromichi; Kusaka, Hirofumi; Imai, Terukuni; Takahashi, Ryosuke; Matsumoto, Sadayuki; Yamamoto, Toru; Yamasaki, Masahiro; Maya, Kiyomi

    1986-01-01

    Eleven patients with a definite diagnosis of multiple sclerosis were examined in terms of correlations between the clinical features and the results of cranial computed tomography (CT), and magnetic resonance imaging (MRI). Results: In 5 of the 11 patients, both CT and MRI demonstrated lesions consistent with a finding of multiple sclerosis. In 3 patients, only MRI demonstrated lesions. In the remaining 3 patients, neither CT nor MRI revealed any lesion in the brain. All 5 patients who showed abnormal findings on both CT and MRI had clinical signs either of cerebral or brainstem - cerebellar lesions. On the other hand, two of the 3 patients with normal CT and MRI findings had optic-nerve and spinal-cord signs. Therefore, our results suggested relatively good correlations between the clinical features, CT, and MRI. MRI revealed cerebral lesions in two of the four patients with clinical signs of only optic-nerve and spinal-cord lesions. MRI demonstrated sclerotic lesions in 3 of the 6 patients whose plaques were not detected by CT. In conclusion, MRI proved to be more helpful in the demonstration of lesions attributable to chronic multiple sclerosis. (author)

  7. Confirmation test on confinement performance of improved glove box

    International Nuclear Information System (INIS)

    Miura, S.; Kanazawa, J.; Nakajima, M.; Sakuno, K.; Miyata, H.

    1995-01-01

    Glove boxes are used at nuclear facilities to confine radioactive materials by ensuring a high level of airtightness and negative internal pressure. The allowable rate of air leakage is 0.1% vol/hr or less at the pre-service inspection. The negative pressure value is normally maintained at about -30 mm H 2 O. Structural strength and confinement reliability of glove boxes during earthquake are major concerns, and most important glove boxes are designed to withstand seismic class A events is Japan. This paper describes vibration tests done to confirm that improve large-sized glove boxes maintain their confinement performance and structural strength even during earthquake and that the design analysis methods used are appropriate. (author). 1 ref., 6 figs., 3 tabs

  8. Experimenter Confirmation Bias and the Correction of Science Misconceptions

    Science.gov (United States)

    Allen, Michael; Coole, Hilary

    2012-06-01

    This paper describes a randomised educational experiment ( n = 47) that examined two different teaching methods and compared their effectiveness at correcting one science misconception using a sample of trainee primary school teachers. The treatment was designed to promote engagement with the scientific concept by eliciting emotional responses from learners that were triggered by their own confirmation biases. The treatment group showed superior learning gains to control at post-test immediately after the lesson, although benefits had dissipated after 6 weeks. Findings are discussed with reference to the conceptual change paradigm and to the importance of feeling emotion during a learning experience, having implications for the teaching of pedagogies to adults that have been previously shown to be successful with children.

  9. BUSTED BUTTE TEST FACILITY GROUND SUPPORT CONFIRMATION ANALYSIS

    International Nuclear Information System (INIS)

    Bonabian, S.

    1998-01-01

    The main purpose and objective of this analysis is to confirm the validity of the ground support design for Busted Butte Test Facility (BBTF). The highwall stability and adequacy of highwall and tunnel ground support is addressed in this analysis. The design of the BBTF including the ground support system was performed in a separate document (Reference 5.3). Both in situ and seismic loads are considered in the evaluation of the highwall and the tunnel ground support system. In this analysis only the ground support designed in Reference 5.3 is addressed. The additional ground support installed (still work in progress) by the constructor is not addressed in this analysis. This additional ground support was evaluated by the A/E during a site visit and its findings and recommendations are addressed in this analysis

  10. Ultrasonographic Confirmation of Endotracheal Tube Position in Neonates.

    Science.gov (United States)

    Najib, Khadijehsadat; Pishva, Narjes; Amoozegar, Hamid; Pishdad, Parisa; Fallahzadeh, Ebrahim

    2016-10-08

    To compare endotracheal tube tip-to-carina distance obtained by ultrasonography vs. that obtained by chest X-ray in neonates. After endotracheal intubation of 40 neonates, chest X-ray and, within one hour, ultrasonography was obtained for each patient for measurement of endotracheal tube tip-to-carina distance. Means of endotracheal tube tip-to-carina distances were not significantly different by both modalities (mean difference 0.157 cm, P= 0.06). In addition, an intraclass correlation was observed between them (r2= 0.61, 95% CI= 0.26, 0.79). Ultrasonography and chest X-ray are equally accurate for determination of endotracheal tube tip-to-carina in infants. As ultrasonography is more easily available and is safer than X-ray, it may be a better modality for confirming proper placement of endotracheal tube in neonates.

  11. Improved statistical confirmation of margins for setpoints and transients

    International Nuclear Information System (INIS)

    Nutt, W.T.

    2001-01-01

    Framatome ANP Richland, Inc. has developed an integrated, automated, statistical methodology for Pressurized Water Reactors (PWRs). Margins for transients and calculated trips are confirmed using several new applications of probability theory. The methods used for combining statistics reduces the conservatisms inherent in conventional methods and avoids the numerical limitations and time constraints imposed by Monte Carlo techniques. The new methodology represents the state of the art in the treatment of uncertainties for reactor protection systems. It all but eliminates concerns with the calculated trips for PWRs and by improving the margin for all transients will allow for far more aggressive peaking limits and fuel management schemes. The automated nature of the bulk of this process saves Framatome ANP time and effort, minimizes the potential for errors and makes the analysis for all cycles and plants consistent. The enhanced margins remove analytical limitations from the customer and allow for more economical operation of the plant. (authors)

  12. Model-independent confirmation of the $Z(4430)^-$ state

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Balagura, Vladislav; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Bauer, Thomas; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; van den Brand, Johannes; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Brown, Henry; Bursche, Albert; Busetto, Giovanni; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carranza-Mejia, Hector; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Giani', Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, Vladimir; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gordon, Hamish; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; Hartmann, Thomas; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jezabek, Marek; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kaballo, Michael; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanciotti, Elisa; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Liu, Guoming; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lu, Haiting; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Manca, Giulia; Mancinelli, Giampiero; Manzali, Matteo; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Moggi, Niccolò; Molina Rodriguez, Josue; Monteil, Stephane; Moran, Dermot; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Muresan, Raluca; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pazos Alvarez, Antonio; Pearce, Alex; Pellegrino, Antonio; Pepe Altarelli, Monica; Perazzini, Stefano; Perez Trigo, Eliseo; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Powell, Andrew; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Alexander; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Roa Romero, Diego; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruffini, Fabrizio; Ruiz, Hugo; Ruiz Valls, Pablo; Sabatino, Giovanni; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sapunov, Matvey; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Savrie, Mauro; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Seco, Marcos; Semennikov, Alexander; Senderowska, Katarzyna; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spinella, Franco; Spradlin, Patrick; Stagni, Federico; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szilard, Daniela; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; Voss, Helge; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiedner, Dirk; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wu, Suzhi; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Feng; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2015-01-01

    The decay $B^0\\to \\psi(2S) K^+\\pi^-$ is analyzed using $\\rm 3~fb^{-1}$ of $pp$ collision data collected with the LHCb detector. A model-independent description of the $\\psi(2S) \\pi$ mass spectrum is obtained, using as input the $K\\pi$ mass spectrum and angular distribution derived directly from data, without requiring a theoretical description of resonance shapes or their interference. The hypothesis that the $\\psi(2S)\\pi$ mass spectrum can be described in terms of $K\\pi$ reflections alone is rejected with more than 8$\\sigma$ significance. This provides confirmation, in a model-independent way, of the need for an additional resonant component in the mass region of the $Z(4430)^-$ exotic state.

  13. Clinical epidemiological and echographic characterization of patients with confirmed dengue

    International Nuclear Information System (INIS)

    Martinez Lopez, Jose Angel

    2010-01-01

    A descriptive and cross-sectional study of 902 patients with confirmed diagnosis of dengue and admitted at the 'Dr. Juan Bruno Zayas Alfonso' General Hospital was carried out in Santiago de Cuba, from April to October, 2006, in order to characterize them from the clinical, epidemiological and echographic point of view. Women belonging to the 36-45 year-old group were the most affected and the abdominal pain constituted the main clinical symptom of alarm in all those affected. The echographic findings took place between the fourth and sixth days of clinical course, mainly in men, and the onset of the perivesicular edema was very early in this stage, with primacy in women. The patients with cholecystectomy presented fluid infiltration in the vesicular channel, while the loops of bowel were observed loosened and their walls were edematous

  14. The Influence of Confirmation Bias on Memory and Source Monitoring.

    Science.gov (United States)

    Frost, Peter; Casey, Bridgette; Griffin, Kaydee; Raymundo, Luis; Farrell, Christopher; Carrigan, Ryan

    2015-01-01

    Two experiments were conducted to examine whether recognition memory for information and/or its source are influenced by confirmation bias. During Phase 1, subjects were shown a summary about the issue of gun control and asked to indicate a position on the issue. During Phase 2, 12 abstracts (Experiment 1) or social media posts (Experiment 2) were shown, one at a time. Posts in Experiment 2 were associated with either friends or strangers. Participants indicated whether they wanted to read a more extensive version of each abstract (Experiment 1) or post (Experiment 2). Phase 3 was the memory phase. Thirty-two abstract titles (Experiment 1) or posts (Experiment 2) were shown one at a time. Participants indicated yes or no, and whether they recognized the titles/posts from the last phase. Recognition memory for information that supported the participants' viewpoint was higher than that for opposing information.

  15. The first confirmed case of Diphyllobothrium latum in Brazil

    Directory of Open Access Journals (Sweden)

    FLN Santos

    2005-10-01

    Full Text Available Diphyllobothriasis is an infection of the small intestine by the broad tapeworm Diphyllobothrium sp. The associated symptomatology is nonspecific, but megaloblastic anemia is a well-described complication. Although the infection is common in temperate regions, descriptions in South America have so far been limited to Chile, Peru, and a few cases in Argentina. This paper presents the first confirmed Brazilian case of diphyllobothriasis. A 29-years-old woman living in Salvador (state of Bahia apparently acquired the infection from eating sushi. The diagnosis was based on fecal examination that revealed a large quantity of operculated eggs. A single dose of praziquantel (600 mg was sufficient to cure the infection.

  16. Takotsubo cardiomyopathy in myasthaenia gravis crisis confirmed by cardiac MRI.

    Science.gov (United States)

    Harries, I B; Levoir, H; Bucciarelli-Ducci, C; Ramcharitar, S

    2015-09-28

    Myasthaenia gravis crisis and Takotsubo cardiomyopathy are rare conditions that can be precipitated by emotional or physical stress. Myasthaenia gravis has a variety of cardiac manifestations but Takotsubo cardiomyopathy, particularly in male patients, has rarely been reported. We describe a unique case of a 70-year-old man who developed Takotsubo cardiomyopathy during his first presentation with a myasthaenia gravis crisis. He had not received plasmapharesis or immunoglobulin therapy. Striking ECG traces and cardiac MRI helped to confirm the diagnosis. Cardiac manifestations of myasthaenia gravis and myasthaenia gravis itself have overlapping symptoms; the importance of cardiac monitoring and clinical vigilance in such cases is discussed. The utility of cardiac MRI in assessing cardiac manifestations of myasthaenia gravis is also highlighted. 2015 BMJ Publishing Group Ltd.

  17. Federal Court of Administration confirms preclusion of objections

    International Nuclear Information System (INIS)

    1982-01-01

    1. The preclusion established as a rule of law in sub-section 1 of sect. 3 of the Ordinance concerning the Procedure for Licensing Nuclear Installations is not only applicable to administrative proceedings, but also to administrative court proceedings. 2. In an advanced process situation, the preclusion rule of sub-section 1 of sect. 3 of the Ordinance concerning the Procedure for Licensing Nuclear Installations is applicable, this does not constitute a violation of the principle of having 'fair' proceedings. 3. Objections as defined by the above-mentioned regulation have to be presented with reference to the project and within the period allowed, during the licensing procedure concerning the project. The Federal Court of Administration has confirmed the preclusion of objections. The court dismissed the complainant's appeal against the non-admission of appeal ruled in the decision of the Administrative Court of Baden-Wuerttemberg of Nov. 7, 1980. (orig./HP) [de

  18. The classical nova hibernation scenario: a definitive confirmation

    Science.gov (United States)

    Gaensicke, Boris

    2017-08-01

    The detached white dwarf plus M-dwarf binary LL Eri exhibits truly unique behaviour within this class of compact binaries. As part of a COS snapshot survey, we detected large-amplitude variability in the ultraviolet flux of the white dwarf, confirmed by extensive ground-based blue-band photometry. The three independent frequencies detected in the light curves clearly identify this variability as non-radial pulsations of the white dwarf. However, with a hydrogen atmosphere and Teff=17200K, this white dwarf is nearly 5000K hotter than the canonical instability strip.The COS spectrum, albeit noisy, reveals that the metal lines typically detected in this class of stars, arising from material captured from the M-dwarf wind, are very broad. If interpreted as rotationally broadened, they imply a spin of only a few minutes. Such a short period could be explained by a past phase of intense accretion of mass and angular momentum. It has been postulated for over thirty years that classical nova eruptions on the white dwarf could cause such switching from a semi-detached to a detached binary configuration, during which the system hibernates - yet, to date no hibernating nova has been identified. However, the broad lines could also be due to pulsation-driven surface velocity fields, in which case the nature and past evolution of LL Eri would not be easily linked to any exisiting scenario for compact binary evolution. We propose to obtain a deeper COS observations to unambiguosly determine whether the cause of the observed line broadening is due to rapid rotation, which would unequivocally confirm the hibernation scenario.

  19. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, Egon; Stenager, E N; Knudsen, Lone

    1994-01-01

    In a cross-sectional study of 117 randomly selected patients (52 men, 65 women) with definite multiple sclerosis, it was found that 76 percent were married or cohabitant, 8 percent divorced. Social contacts remained unchanged for 70 percent, but outgoing social contacts were reduced for 45 percent....... Ninety-five percent lived in own house or flat and 70 percent received disablement pension. More than half of the patients (56.4 percent) were dependent on help from close relatives, most frequently spouse. The need for help, the risk of divorce, loss of contact with relatives, difficulty in going out...

  20. [Multiple myeloma].

    Science.gov (United States)

    Abe, Masahiro; Miki, Hirokazu; Nakamura, Shingen

    2016-03-01

    Owing to the positive clinical benefits obtained with new agents, complete remission (CR) can be used as a surrogate for overall survival, and should be achieved. Although multiple myeloma is a heterogeneous disease in terms of myeloma cell- and patient-related risk factors, patients should receive the most effective combination therapy based on proteasome inhibitors and/or immunomodulatory drugs (IMiDs) as backbone medication irrespective of the risks encountered in the setting of induction therapy ("one-size-fits-all" therapy), followed by consolidation/maintenance therapy to achieve CR with the ultimate goal of extended survival. Myeloma-defining biomarkers have been established to identify high-risk smoldering myeloma requiring treatment. The development of salvage treatments yielding better outcomes for relapsed/refractory myeloma is urgently needed. Upcoming novel molecular targeting agents with different modes of action and immunotherapeutic agents will be integrated into myeloma treatment regimens with a great therapeutic impact, and further evolution of the treatment paradigm for multiple myeloma is eagerly anticipated.

  1. Multiple inflation

    International Nuclear Information System (INIS)

    Murphy, P.J.

    1987-01-01

    The Theory of Inflation, namely, that at some point the entropy content of the universe was greatly increased, has much promise. It may solve the puzzles of homogeneity and the creation of structure. However, no particle physics model has yet been found that can successfully drive inflation. The difficulty in satisfying the constraint that the isotropy of the microwave background places on the effective potential of prospective models is immense. In this work we have codified the requirements of such models in a most general form. We have carefully calculated the amounts of inflation the various problems of the Standard Model need for their solution. We have derived a completely model independent upper bond on the inflationary Hubble parameter. We have developed a general notation with which to probe the possibilities of Multiple Inflation. We have shown that only in very unlikely circumstances will any evidence of an earlier inflation, survive the de Sitter period of its successor. In particular, it is demonstrated that it is most unlikely that two bouts of inflation will yield high amplitudes of density perturbations on small scales and low amplitudes on large. We conclude that, while multiple inflation will be of great theoretical interest, it is unlikely to have any observational impact

  2. From Lucy to Kadanuumuu: balanced analyses of Australopithecus afarensis assemblages confirm only moderate skeletal dimorphism

    Directory of Open Access Journals (Sweden)

    Philip L. Reno

    2015-04-01

    Full Text Available Sexual dimorphism in body size is often used as a correlate of social and reproductive behavior in Australopithecus afarensis. In addition to a number of isolated specimens, the sample for this species includes two small associated skeletons (A.L. 288-1 or “Lucy” and A.L. 128/129 and a geologically contemporaneous death assemblage of several larger individuals (A.L. 333. These have driven both perceptions and quantitative analyses concluding that Au. afarensis was markedly dimorphic. The Template Method enables simultaneous evaluation of multiple skeletal sites, thereby greatly expanding sample size, and reveals that A. afarensis dimorphism was similar to that of modern humans. A new very large partial skeleton (KSD-VP-1/1 or “Kadanuumuu” can now also be used, like Lucy, as a template specimen. In addition, the recently developed Geometric Mean Method has been used to argue that Au. afarensis was equally or even more dimorphic than gorillas. However, in its previous application Lucy and A.L. 128/129 accounted for 10 of 11 estimates of female size. Here we directly compare the two methods and demonstrate that including multiple measurements from the same partial skeleton that falls at the margin of the species size range dramatically inflates dimorphism estimates. Prevention of the dominance of a single specimen’s contribution to calculations of multiple dimorphism estimates confirms that Au. afarensis was only moderately dimorphic.

  3. Managing a duopolistic water market with confirmed proposals. An experiment

    Directory of Open Access Journals (Sweden)

    García-Gallego, Aurora

    2012-03-01

    Full Text Available We report results from experimental water markets in which owners of two different sources of water supply water to households and farmers. The final water quality consumed by each type of consumer is determined through mixing of qualities from two different resources. We compare the standard duopolistic market structure with an alternative market clearing mechanism inspired by games with confirmed strategies (which have been shown to yield collusive outcomes. As in the static case, complex dynamic markets operating under a confirmed proposals protocol yield less efficient outcomes because coordination among independent suppliers has the usual effects of restricting output and increasing prices to the users. Our results suggest that, when market mechanisms are used to allocate water to its users, the rule of thumb used by competition authorities can also serve as a guide towards water market regulation.

    Se presentan resultados de un experimento con mercados acuíferos en el que los propietarios de agua de distinta calidad la ofrecen a hogares y agricultores. La calidad finalmente consumida por cada tipo de consumidor se determina a partir de una mezcla de las dos calidades. Se compara el duopolio estándar con una forma alternativa de cerrar el mercado que está inspirada en los juegos con propuestas confirmadas, que consiguen resultados relativamente más colusivos. Como en el caso estático, los mercados dinámicos y complejos que operan bajo un protocolo de propuestas confirmadas son menos eficientes porque la coordinación entre oferentes independientes tiene los efectos de restringir el output y de provocar un crecimiento de los precios. Nuestros resultados sugieren que cuando los mecanismos de mercado se utilizan para distribuir el agua a sus usuarios, la regla utilizada por parte de las autoridades de la competencia puede servir también como guía para la regulación de los mercados acuíferos.

  4. Computer assisted radionuclide angiography to confirm reversible ischemic cerebral dysfunction

    International Nuclear Information System (INIS)

    Buell, U.; Lanksch, W.; Tosch, U.; Kleinhans, E.; Steinhoff, H.

    1982-01-01

    Computer assisted radionuclide angiography (CARNA) was employed in patients with transient ischemic attack (TIA) or prolonged reversible ischemic neurologic deficit (PRIND) to establish the sensitivity of CARNA in detecting and quantifying changes of cerebral perfusion in such selected patients. Moreover, results of CARNA were compared with findings of cranial radiographic angiography (RGA) to obtain data on combined sensitivities of these methods. CARNA may be the preferred noninvasive procedure employed because it detects and quantifies the vascular supply disorder in patients with TIA and PRIND. If no computer assistance is used to evaluate cranial radionuclide angiography, results are considerable less accurate. Specifity of CARNA is 84.6%. If CARNA is negative (25.2% in TIA; 12.7% in PRIND), a further method must be employed to confirm the cranial vascular origin of the attack. This may be RGA in TIA and transmission computed axial tomography (T-CAT) T-CAT in PRIND. This diagnos - tic sequence lead to 92.4% true positive in TIA and to 93.2% true positives in PRIND

  5. Imaging modalities used to confirm diaphragmatic hernia in small animals

    International Nuclear Information System (INIS)

    Williams, J.; Leveille, R.; Myer, C.W.

    1998-01-01

    When a patient is presented for treatment following a traumatic accident such as being hit by a car, thoracic radiographs are usually an integral part of the overall diagnostic evaluation. Diagnosis at diaphragmatic hernia (DH) is often challenging in small animals. The thorax may contain substantial fluid, thereby masking the presence of cranially displaced abdominal soft tissues (e.g., liver or spleen). The most common cause of decreased radiographic visualization of the diaphragm on survey radiographs is pleural fluid; however, the second most common cause is DH. Obviously, if a gas-filledviscus is identified within the thoracic cavity on survey radiographs, the diagnosis of DH is straightforward and relatively routine. If, however, there is substantial pleural effusion and the herniated structure is a soft tissue parenchymal organ (e.g., liver or spleen), the diagnosis is less clearly defined on survey radiographs. This review discusses the various imaging modalities (survey, positional, and contrast-enhanced radiographs and ultrasonography) that can be used in the diagnosis or confirmation of DH

  6. Gluten Psychosis: Confirmation of a New Clinical Entity

    Directory of Open Access Journals (Sweden)

    Elena Lionetti

    2015-07-01

    Full Text Available Non-celiac gluten sensitivity (NCGS is a syndrome diagnosed in patients with symptoms that respond to removal of gluten from the diet, after celiac disease and wheat allergy have been excluded. NCGS has been related to neuro-psychiatric disorders, such as autism, schizophrenia and depression. A singular report of NCGS presenting with hallucinations has been described in an adult patient. We report a pediatric case of a psychotic disorder clearly related to NCGS and investigate the causes by a review of literature. The pathogenesis of neuro-psychiatric manifestations of NCGS is unclear. It has been hypothesized that: (a a “leaky gut” allows some gluten peptides to cross the intestinal membrane and the blood brain barrier, affecting the endogenous opiate system and neurotransmission; or (b gluten peptides may set up an innate immune response in the brain similar to that described in the gut mucosa, causing exposure from neuronal cells of a transglutaminase primarily expressed in the brain. The present case-report confirms that psychosis may be a manifestation of NCGS, and may also involve children; the diagnosis is difficult with many cases remaining undiagnosed. Well-designed prospective studies are needed to establish the real role of gluten as a triggering factor in neuro-psychiatric disorders.

  7. Synthesis gas demonstration plant program, Phase I. Site confirmation report

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-01

    With few reservations, the Baskett, Kentucky site exhibits the necessary characteristics to suggest compatibility with the proposed Synthesis Gas Demonstration Plant Project. An evaluation of a broad range of technical disciplinary criteria in consideration of presently available information indicated generally favorable conditions or, at least, conditions which could be feasibly accommodated in project design. The proximity of the Baskett site to market areas and sources of raw materials as well as a variety of transportation facilities suggests an overall favorable impact on Project economic feasibility. Two aspects of environmental engineering, however, have been identified as areas where the completion or continuation of current studies are required before removing all conditions on site suitability. The first aspect involves the current contradictory status of existing land use and planning ordinances in the site area. Additional investigation of the legality of, and local attitudes toward, these present plans is warranted. Secondly, terrestrial and aquatic surveys of plant and animal life species in the site area must be completed on a seasonal basis to confirm the preliminary conclusion that no exclusionary conditions exist.

  8. Confirming the Value of Swimming-Performance Models for Adolescents.

    Science.gov (United States)

    Dormehl, Shilo J; Robertson, Samuel J; Barker, Alan R; Williams, Craig A

    2017-10-01

    To evaluate the efficacy of existing performance models to assess the progression of male and female adolescent swimmers through a quantitative and qualitative mixed-methods approach. Fourteen published models were tested using retrospective data from an independent sample of Dutch junior national-level swimmers from when they were 12-18 y of age (n = 13). The degree of association by Pearson correlations was compared between the calculated differences from the models and quadratic functions derived from the Dutch junior national qualifying times. Swimmers were grouped based on their differences from the models and compared with their swimming histories that were extracted from questionnaires and follow-up interviews. Correlations of the deviations from both the models and quadratic functions derived from the Dutch qualifying times were all significant except for the 100-m breaststroke and butterfly and the 200-m freestyle for females (P backstroke for males and 200-m freestyle for males and females were almost directly proportional. In general, deviations from the models were accounted for by the swimmers' training histories. Higher levels of retrospective motivation appeared to be synonymous with higher-level career performance. This mixed-methods approach helped confirm the validity of the models that were found to be applicable to adolescent swimmers at all levels, allowing coaches to track performance and set goals. The value of the models in being able to account for the expected performance gains during adolescence enables quantification of peripheral factors that could affect performance.

  9. Confirmation of a blocked amino terminus of sulfhydryl oxidase

    International Nuclear Information System (INIS)

    Janolino, V.G.; Morrison-Rowe, S.J.; Swaisgood, H.E.

    1990-01-01

    The isolation of sulfhydryl oxidase from bovine milk in a suitably pure form for sequencing was carried out by transient covalent affinity chromatography of diafiltered whey using cysteinylsuccinamidopropyl-glass as matrix. The glutathione-eluted proteins were separated by SDS-PAGE. By radiolabeling the affinity chromatography-purified enzyme with [ 14 C]iodoacetate before subjecting to SDS-PAGE, the sulfhydryl oxidase band was identified, because sulfhydryl oxidase is known to be inactivated by alkylation of one sulfhydryl group per mole. The results confirmed that sulfhydryl oxidase corresponds to the 85 (± 5)-kDa band observed on SDS-PAGE. The protein band corresponding to radiolabeled sulfhydryl oxidase was recovered from SDS-PAGE gels by electrophoretic elution and by electroblotting on polyvinylidene difluoride membrane and subjected to gas phase sequencing. Precautions were taken during electrophoretic elution to prevent reactions that result in N-terminal blocking. Both methods of protein recovery yielded negative results when subjected to sequence analysis indicating that the N-terminus of sulfhydryl oxidase is blocked

  10. Confirmation of theoretical colour predictions for layering dental composite materials.

    Science.gov (United States)

    Mikhail, Sarah S; Johnston, William M

    2014-04-01

    The aim of this study is to confirm the theoretical colour predictions for single and double layers of dental composite materials on an opaque backing. Single and double layers of composite resins were fabricated, placed in optical contact with a grey backing and measured for spectral radiance. The spectral reflectance and colour were directly determined. Absorption and scattering coefficients as previously reported, the measured thickness of the single layers and the effective reflectance of the grey backing were utilized to theoretically predict the reflectance of the single layer using corrected Kubelka-Munk reflectance theory. For double layers the predicted effective reflectance of the single layer was used as the reflectance of the backing of the second layer and the thickness of the second layer was used to predict the reflectance of the double layer. Colour differences, using both the CIELAB and CIEDE2000 formulae, measured the discrepancy between each directly determined colour and its corresponding theoretical colour. The colour difference discrepancies generally ranged around the perceptibility threshold but were consistently below the respective acceptability threshold. This theory can predict the colour of layers of composite resin within acceptability limits and generally also within perceptibility limits. This theory could therefore be incorporated into computer-based optical measuring instruments that can automate the shade selections for layers of a more opaque first layer under a more translucent second layer for those clinical situations where an underlying background colour and a desirable final colour can be measured. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Pathological Confirmation of Optic Neuropathy in Familial Dysautonomia

    Science.gov (United States)

    Palma, Jose-Alberto; Hedges, Thomas R.; Laver, Nora V.; Farhat, Nada; Norcliffe-Kaufmann, Lucy; Kaufmann, Horacio

    2017-01-01

    Abstract Clinical data suggest that optic neuropathy and retinal ganglion cell loss are the main cause of visual decline in patients with familial dysautonomia, but this has not previously been confirmed by pathological analyses. We studied retinas and optic nerves in 6 eyes from 3 affected patients obtained at autopsy. Analyses included routine neurohistology and immunohistochemistry for neurofilaments, cytochrome c oxidase (COX), and melanopsin-containing ganglion cells. We observed profound axon loss in the temporal portions of optic nerves with relative preservation in the nasal portions; this correlated with clinical and optical coherence tomography findings in 1 patient. Retinal ganglion cell layers were markedly reduced in the central retina, whereas melanopsin-containing ganglion cells were relatively spared. COX staining was reduced in the temporal portions of the optic nerve indicating reduced mitochondrial density. Axonal swelling with degenerating lysosomes and mitochondria were observed by electron microscopy. These findings support the concept that there is a specific optic neuropathy and retinopathy in patients with familial dysautonomia similar to that seen in other optic neuropathies with mitochondrial dysfunction. This raises the possibility that defective expression of the IkB kinase complex-associated protein (IKAP) resulting from mutations in IKBKAP affects mitochondrial function in the metabolism-dependent retinal parvocellular ganglion cells in this condition. PMID:28395083

  12. Anaplasma phagocytophilum in Danish sheep: confirmation by DNA sequencing

    Directory of Open Access Journals (Sweden)

    Thamsborg Stig M

    2009-12-01

    Full Text Available Abstract Background The presence of Anaplasma phagocytophilum, an Ixodes ricinus transmitted bacterium, was investigated in two flocks of Danish grazing lambs. Direct PCR detection was performed on DNA extracted from blood and serum with subsequent confirmation by DNA sequencing. Methods 31 samples obtained from clinically normal lambs in 2000 from Fussingø, Jutland and 12 samples from ten lambs and two ewes from a clinical outbreak at Feddet, Zealand in 2006 were included in the study. Some of the animals from Feddet had shown clinical signs of polyarthritis and general unthriftiness prior to sampling. DNA extraction was optimized from blood and serum and detection achieved by a 16S rRNA targeted PCR with verification of the product by DNA sequencing. Results Five DNA extracts were found positive by PCR, including two samples from 2000 and three from 2006. For both series of samples the product was verified as A. phagocytophilum by DNA sequencing. Conclusions A. phagocytophilum was detected by molecular methods for the first time in Danish grazing lambs during the two seasons investigated (2000 and 2006.

  13. Confirmation of translocated gastrointestinal bacteria in a neonatal model.

    Science.gov (United States)

    Moy, J; Lee, D J; Harmon, C M; Drongowski, R A; Coran, A G

    1999-11-01

    The hypothesis that enteric bacteria translocate from the gastrointestinal (GI) tract to extraintestinal sites has been extensively studied. However, definitive evidence that spontaneous bacterial translocation and dissemination from the GI tract to extraintestinal sites occur in a neonatal model has been lacking. The aim of this study was to confirm this phenomenon by tracking enterally administered, plasmid-labeled bacteria to extraintestinal sites. Escherichia coli 07:K1 (E. coli K1) with and without a nontransferable, ampicillin resistance plasmid (pGEM-7) were used in this study. Newborn New Zealand white rabbit pups were separated into three treatment groups: transformed E. coli K1 (E. coli K1 + pGEM-7, n = 20), nontransformed E. coli K1 (n = 12), and control pups (no bacteria, n = 7). Pups were enterally fed 10% Formulac solution supplemented with a suspension of bacteria respective to their group. After the pups fed twice daily for 2 days, representative tissue specimens from the small bowel (SB), mesenteric lymph nodes (MLNs), spleen (SPL), and liver (LIV) were aseptically harvested and tested for culture growth in ampicillin-supplemented medium. Positive growths of plasmid-induced ampicillin-resistant bacteria were detected in tissue specimens harvested from rabbits fed transformed E. coli K1, but were not detected in the other groups. This experiment demonstrated conclusively that transformed E. coli K1 fed to healthy rabbit pups spontaneously translocated from the intestinal lumen and subsequently disseminated to the mesenteric lymph nodes, spleen, and liver. Copyright 1999 Academic Press.

  14. Transit Timing Observations from Kepler: II. Confirmation of Two Multiplanet Systems via a Non-parametric Correlation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ford, Eric B.; /Florida U.; Fabrycky, Daniel C.; /Lick Observ.; Steffen, Jason H.; /Fermilab; Carter, Joshua A.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Holman, Matthew J.; /Harvard-Smithsonian Ctr. Astrophys.; Lissauer, Jack J.; /NASA, Ames; Moorhead, Althea V.; /Florida U.; Morehead, Robert C.; /Florida U.; Ragozzine, Darin; /Harvard-Smithsonian Ctr. Astrophys.; Rowe, Jason F.; /NASA, Ames /SETI Inst., Mtn. View /San Diego State U., Astron. Dept.

    2012-01-01

    We present a new method for confirming transiting planets based on the combination of transit timing variations (TTVs) and dynamical stability. Correlated TTVs provide evidence that the pair of bodies are in the same physical system. Orbital stability provides upper limits for the masses of the transiting companions that are in the planetary regime. This paper describes a non-parametric technique for quantifying the statistical significance of TTVs based on the correlation of two TTV data sets. We apply this method to an analysis of the transit timing variations of two stars with multiple transiting planet candidates identified by Kepler. We confirm four transiting planets in two multiple planet systems based on their TTVs and the constraints imposed by dynamical stability. An additional three candidates in these same systems are not confirmed as planets, but are likely to be validated as real planets once further observations and analyses are possible. If all were confirmed, these systems would be near 4:6:9 and 2:4:6:9 period commensurabilities. Our results demonstrate that TTVs provide a powerful tool for confirming transiting planets, including low-mass planets and planets around faint stars for which Doppler follow-up is not practical with existing facilities. Continued Kepler observations will dramatically improve the constraints on the planet masses and orbits and provide sensitivity for detecting additional non-transiting planets. If Kepler observations were extended to eight years, then a similar analysis could likely confirm systems with multiple closely spaced, small transiting planets in or near the habitable zone of solar-type stars.

  15. TRANSIT TIMING OBSERVATIONS FROM KEPLER. II. CONFIRMATION OF TWO MULTIPLANET SYSTEMS VIA A NON-PARAMETRIC CORRELATION ANALYSIS

    International Nuclear Information System (INIS)

    Ford, Eric B.; Moorhead, Althea V.; Morehead, Robert C.; Fabrycky, Daniel C.; Steffen, Jason H.; Carter, Joshua A.; Fressin, Francois; Holman, Matthew J.; Ragozzine, Darin; Charbonneau, David; Lissauer, Jack J.; Rowe, Jason F.; Borucki, William J.; Bryson, Stephen T.; Burke, Christopher J.; Caldwell, Douglas A.; Welsh, William F.; Allen, Christopher; Batalha, Natalie M.; Buchhave, Lars A.

    2012-01-01

    We present a new method for confirming transiting planets based on the combination of transit timing variations (TTVs) and dynamical stability. Correlated TTVs provide evidence that the pair of bodies is in the same physical system. Orbital stability provides upper limits for the masses of the transiting companions that are in the planetary regime. This paper describes a non-parametric technique for quantifying the statistical significance of TTVs based on the correlation of two TTV data sets. We apply this method to an analysis of the TTVs of two stars with multiple transiting planet candidates identified by Kepler. We confirm four transiting planets in two multiple-planet systems based on their TTVs and the constraints imposed by dynamical stability. An additional three candidates in these same systems are not confirmed as planets, but are likely to be validated as real planets once further observations and analyses are possible. If all were confirmed, these systems would be near 4:6:9 and 2:4:6:9 period commensurabilities. Our results demonstrate that TTVs provide a powerful tool for confirming transiting planets, including low-mass planets and planets around faint stars for which Doppler follow-up is not practical with existing facilities. Continued Kepler observations will dramatically improve the constraints on the planet masses and orbits and provide sensitivity for detecting additional non-transiting planets. If Kepler observations were extended to eight years, then a similar analysis could likely confirm systems with multiple closely spaced, small transiting planets in or near the habitable zone of solar-type stars.

  16. Microgenetic patterns of children’s multiplication learning: Confirming the overlapping waves model by latent growth modeling

    NARCIS (Netherlands)

    van der Ven, S.H.G.; Boom, J.; Kroesbergen, E.H.; Leseman, P.P.M.

    2012-01-01

    Variability in strategy selection is an important characteristic of learning new skills such as mathematical skills. Strategies gradually come and go during this development. In 1996, Siegler described this phenomenon as "overlapping waves." In the current microgenetic study, we attempted to model

  17. Multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E; Knudsen, L; Jensen, K

    1994-01-01

    a significant correlation between results of an attention and perceptual motor speed test i.e. Symbol Digit Modalities test and the ability to read TV-subtitles, but no correlation was found with another attention and perceptual motor speed test, or verbal or visual memory. No correlation between the use......In a cross-sectional study of 94 patients (42 males, 52 females) with definite multiple sclerosis (MS) in the age range 25-55 years, the correlation of neuropsychological tests with the ability to read TV-subtitles and with the use of sedatives is examined. A logistic regression analysis reveals...... of sedatives and results on neuropsychological tests was found. Anxiety was not correlated with the ability to read TV-subtitles. It is concluded that visual deficits but not the use of sedatives may be a confounding factor in neuropsychological testing in MS....

  18. [Multiple apheresis].

    Science.gov (United States)

    Coffe, C

    2007-05-01

    Multiple apheresis makes it possible to obtain at least two labile blood components from a single donor using a cell separator. It can be either multicomponent apheresis leading to the preparation of at least two different blood component types or red blood cell apheresis providing two identical red blood cell concentrates. These techniques available in addition to whole blood donation, are modifying collection strategies in many Etablissements Français du Sang and will contribute to improve stock logistics in the future. In areas with insufficient stock, these procedures will help achieve blood component self-sufficiency. The author first describes the principle underlying different--current or future--techniques as well as their advantages and drawbacks. He finally addresses the potential impact of these processes on the evolution of blood collection and the advantages to be gained.

  19. CONFIRMATION OF THE PLANET AROUND HD 95086 BY DIRECT IMAGING

    Energy Technology Data Exchange (ETDEWEB)

    Rameau, J.; Chauvin, G.; Lagrange, A.-M. [UJF-Grenoble 1/CNRS-INSU, Institut de Planétologie et d' Astrophysique de Grenoble (IPAG) UMR 5274, Grenoble F-38041 (France); Meshkat, T.; Kenworthy, M. [Leiden Observatory, Leiden University, P.O. Box 9513, 2300 RA Leiden (Netherlands); Boccaletti, A. [LESIA, Observatoire de Paris, CNRS, University Pierre et Marie Curie Paris 6 and University Denis Diderot Paris 7, 5 place Jules Janssen, F-92195 Meudon (France); Quanz, S. P. [Institute for Astronomy, ETH Zurich, Wolfgang-Pauli-Strasse 27, 8093 Zurich (Switzerland); Currie, T. [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George St., Toronto, Ontario M5S 1A1 (Canada); Mawet, D.; Girard, J. H. [European Southern Observatory, Casilla 19001, Santiago 19 (Chile); Bonnefoy, M., E-mail: julien.rameau@obs.ujf-grenoble.fr [Max Planck Institute für Astronomy, Königsthul 17, D-69117 Heidelberg (Germany)

    2013-12-20

    VLT/NaCo angular differential imaging at L' (3.8 μm) revealed a probable giant planet comoving with the young and early-type HD 95086, also known to harbor an extended debris disk. The discovery was based on the proper motion analysis of two datasets spanning 15 months. However, the second dataset suffered from bad atmospheric conditions, which limited the significance of the re-detection at the 3σ level. In this Letter, we report new VLT/NaCo observations of HD 95086 obtained on 2013 June 26 and 27 at L' to recover the planet candidate. We unambiguously re-detect the companion HD 95086 b with multiple independent pipelines at a signal-to-noise ratio greater than or equal to 5. Combined with previously reported measurements, our astrometry decisively shows that the planet is comoving with HD 95086 and inconsistent with a background object. With a revised mass of 5 ± 2 Jupiter masses, estimated from its L' photometry and ''hot-start'' models at 17 ± 4 Myr, HD 95086 b becomes a new benchmark for further physical and orbital characterization of young giant planets.

  20. Confirming the least massive members of the Pleiades star cluster

    Science.gov (United States)

    Zapatero Osorio, M. R.; Béjar, V. J. S.; Lodieu, N.; Manjavacas, E.

    2018-03-01

    We present optical photometry (i and Z band) and low-resolution spectroscopy (640-1015 nm) of very faint candidate members (J = 20.2-21.2 mag) of the Pleiades star cluster (120 Myr). The main goal is to address their cluster membership via photometric, astrometric, and spectroscopic studies, and to determine the properties of the least massive population of the cluster through the comparison of the data with younger and older spectral counterparts and state-of-the art model atmospheres. We confirm three bona fide Pleiades members that have extremely red optical and infrared colours, effective temperatures of ≈1150 and ≈1350 K, and masses in the interval 11-20 MJup, and one additional likely member that shares the same motion as the cluster but does not appear to be as red as the other members with similar brightness. This latter object requires further near-infrared spectroscopy to fully address its membership in the Pleiades. The optical spectra of two bona fide members were classified as L6-L7 and show features of K I, a tentative detection of Cs I, hydrides, and water vapour with an intensity similar to high-gravity dwarfs of related classification despite their young age. The properties of the Pleiades L6-L7 members clearly indicate that very red colours of L dwarfs are not a direct evidence of ages younger than ≈100 Myr. We also report on the determination of the bolometric corrections for the coolest Pleiades members. These data can be used to interpret the observations of the atmospheres of exoplanets orbiting stars.

  1. Histologically confirmed intracranial tumors managed at Enugu, Nigeria

    Directory of Open Access Journals (Sweden)

    Chika Anele Ndubuisi

    2017-01-01

    Full Text Available Background: There is controversy about the global distribution of intracranial tumors (ICTs. The previous reports from Africa suggested low frequency and different pattern of distribution of brain tumors from what obtains in other continents. The limitations at that time, including paucity of diagnostic facilities and personnel, have improved. Objective: The objective of this study is to analyze the current trend and distribution of histology confirmed brain tumors managed in Enugu, in a decade. Methods: A retrospective analysis of ICTs managed between 2006 and 2015 at Memfys Hospital, Enugu. Only cases with conclusive histology report were analyzed. The World Health Organization ICT classification was used. Results: This study reviewed 252 patients out of 612 neuroimaging diagnosed brain tumors. Mean age was 42.8 years and male-to-female ratio was 1.2:1.0. Annual frequency increased from 11 in 2006 to 55 in 2015. Metastatic brain tumors accounted for 5.6%, and infratentorial tumors represented 16.3%. Frequency of the common primary tumors were meningioma (32.9%, glioma (23.8%, pituitary adenomas (13.5%, and craniopharyngioma (7.5% (P = 0.001. Vestibular schwannoma accounted for 1.2%. Meningioma did not have gender difference (P = 0.714. Medulloblastoma, glioma, and craniopharyngioma were the most common pediatric tumors. About 8.7% presented unconscious (P < 0.001. There was no significant difference between radiology and histology diagnosis (P = 0.932. Conclusion: Meningioma is the most frequent tumor with increasing male incidence, but the frequency of glioma is increasing. Metastasis, acoustic schwannoma, lymphoma, and germ cell tumors seem to be uncommon. Late presentation is the rule.

  2. Physics of mind: Experimental confirmations of theoretical predictions.

    Science.gov (United States)

    Schoeller, Félix; Perlovsky, Leonid; Arseniev, Dmitry

    2018-02-02

    What is common among Newtonian mechanics, statistical physics, thermodynamics, quantum physics, the theory of relativity, astrophysics and the theory of superstrings? All these areas of physics have in common a methodology, which is discussed in the first few lines of the review. Is a physics of the mind possible? Is it possible to describe how a mind adapts in real time to changes in the physical world through a theory based on a few basic laws? From perception and elementary cognition to emotions and abstract ideas allowing high-level cognition and executive functioning, at nearly all levels of study, the mind shows variability and uncertainties. Is it possible to turn psychology and neuroscience into so-called "hard" sciences? This review discusses several established first principles for the description of mind and their mathematical formulations. A mathematical model of mind is derived from these principles. This model includes mechanisms of instincts, emotions, behavior, cognition, concepts, language, intuitions, and imagination. We clarify fundamental notions such as the opposition between the conscious and the unconscious, the knowledge instinct and aesthetic emotions, as well as humans' universal abilities for symbols and meaning. In particular, the review discusses in length evolutionary and cognitive functions of aesthetic emotions and musical emotions. Several theoretical predictions are derived from the model, some of which have been experimentally confirmed. These empirical results are summarized and we introduce new theoretical developments. Several unsolved theoretical problems are proposed, as well as new experimental challenges for future research. Copyright © 2017. Published by Elsevier B.V.

  3. FINDING FOSSIL GROUPS: OPTICAL IDENTIFICATION AND X-RAY CONFIRMATION

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Eric D. [Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (United States); Rykoff, Eli S. [E.O. Lawrence Berkeley National Lab, 1 Cyclotron Rd., Berkeley, CA 94720 (United States); Dupke, Renato A. [Department of Astronomy, University of Michigan, 500 Church St., Ann Arbor, MI 48109 (United States); Mendes de Oliveira, Claudia; Proctor, Robert N. [Departamento de Astronomia, Instituto de Astronomia, Geofisica e Ciencias Atmosfericas da Universidade de Sao Paulo, Rua do Matao 1226, Cidade Universitaria, 05508-090 Sao Paulo (Brazil); Lopes de Oliveira, Raimundo [Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Caixa Postal 369, 13560-970 Sao Carlos, SP (Brazil); Garmire, Gordon P. [Department of Astronomy and Astrophysics, Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Koester, Benjamin P. [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States); McKay, Timothy A., E-mail: milleric@mit.edu [Department of Physics, University of Michigan, 450 Church St., Ann Arbor, MI 48109 (United States)

    2012-03-10

    We report the discovery of 12 new fossil groups (FGs) of galaxies, systems dominated by a single giant elliptical galaxy and cluster-scale gravitational potential, but lacking the population of bright galaxies typically seen in galaxy clusters. These FGs, selected from the maxBCG optical cluster catalog, were detected in snapshot observations with the Chandra X-ray Observatory. We detail the highly successful selection method, with an 80% success rate in identifying 12 FGs from our target sample of 15 candidates. For 11 of the systems, we determine the X-ray luminosity, temperature, and hydrostatic mass, which do not deviate significantly from expectations for normal systems, spanning a range typical of rich groups and poor clusters of galaxies. A small number of detected FGs are morphologically irregular, possibly due to past mergers, interaction of the intra-group medium with a central active galactic nucleus (AGN), or superposition of multiple massive halos. Two-thirds of the X-ray-detected FGs exhibit X-ray emission associated with the central brightest cluster galaxy (BCG), although we are unable to distinguish between AGN and extended thermal galaxy emission using the current data. This sample representing a large increase in the number of known FGs, will be invaluable for future planned observations to determine FG temperature, gas density, metal abundance, and mass distributions, and to compare to normal (non-fossil) systems. Finally, the presence of a population of galaxy-poor systems may bias mass function determinations that measure richness from galaxy counts. When used to constrain power spectrum normalization and {Omega}{sub m}, these biased mass functions may in turn bias these results.

  4. Syndromic diagnosis and management of confirmed mushroom poisonings.

    Science.gov (United States)

    Diaz, James H

    2005-02-01

    To assess the evolving global epidemiology of mushroom poisoning and to identify new and emerging mushroom poisonings and their treatments, a descriptive analysis and review of the world's salient scientific literature on mushroom poisoning was conducted. Data sources from observation studies conducted over the period 1959-2002, and describing 28,018 mushroom poisonings since 1951, were collected from case reports, case series, regional descriptive studies, meta-analyses, and laboratory studies of mushroom poisonings and the toxicokinetics of mycotoxins. Studies included in the review were selected by a MEDLINE search, 1966-2004, an Ovid OLDMEDLINE search, 1951-1965, and a medical library search for sources published before 1951. To better guide clinicians in establishing diagnoses and implementing therapies, despite confusing ingestion histories, data were extracted to permit an expanded syndromic classification of mushroom poisoning based on presentation timing and target organ systemic toxicity. The final 14 major syndromes of mushroom poisoning were stratified first by presentation timing and then by target organ systemic toxicity and included early (syndromes (> or =1 day). There were eight early syndromes (four neurotoxic, two gastrointestinal, two allergic); three late syndromes (hepatotoxic, accelerated nephrotoxic, erythromelalgia); and three delayed syndromes (delayed nephrotoxic, delayed neurotoxic, rhabdomyolysis). Four new mushroom poisoning syndromes were classified including accelerated nephrotoxicity (Amanita proxima, Amanita smithiana), rhabdomyolysis (Tricholoma equestre, Russula subnigricans), erythromelalgia (Clitocybe amoenolens, Clitocybe acromelalgia), and delayed neurotoxicity (Hapalopilus rutilans). In addition, data sources were stratified by three chronological time periods with >1,000 confirmed mushroom ingestions reported and tested for any statistically significant secular trends in case fatalities from mushroom ingestions over the

  5. Nasoduodenal tube placement: Are two views necessary to confirm position?

    International Nuclear Information System (INIS)

    Ngo, Anh-Vu; Done, Stephen; Otto, Randolph; Friedman, Seth; Stanescu, A.L.

    2017-01-01

    Nasoduodenal tube (NDT) placement is typically performed at the bedside and two-view abdominal radiographs are usually used to confirm tube position. Anecdotally, in most instances the lateral view is unnecessary and utilizes more than twice the radiation than an anteroposterior (AP) view alone. We hypothesize that NDT location can be determined using only the AP view, with the NDT position determined on two views utilized as the gold standard. A search was performed for all two- or three-view abdominal radiographs from September 2012 to September 2013 with the phrase ''ND tube'' in the reason field of the requisition. These studies were independently reviewed by two radiologists and scored for anatomical tube position in three different scenarios: AP view alone, the lateral view alone, and both views together, with the latter serving as the gold standard. The anatomical scores were subsequently grouped to reflect clinically significant scenarios. Comparative analysis was performed with the original and clinically grouped scores. A total of 102 patients and 306 separate two-view exams were evaluated. Of the 102 patients, 55 had at least two separate exams. Across raters, concordances of AP and lateral scores relative to the gold standard assessment were 88% and 73% for anatomical scores, and 91.5% and 86.4% for clinically grouped data. Trend differences for fewer errors were found with the AP compared to the lateral view. There were statistically significant group differences with a greater number of false-negative errors in the lateral data set. No clear differences were found when comparing AP and lateral ratings for false-positive errors. Upon review of the common errors, we determined a few imaging findings on AP radiographs that can help assess the need for an additional lateral view. A single AP view is sufficient to determine the NDT position in most cases. Two views should be reserved for cases where the NDT position cannot be

  6. Regulation of pharmacokinetics and targeting-confirmative personalized medicine

    International Nuclear Information System (INIS)

    Kawai, Keiichi

    2011-01-01

    Describedare the current developmental state of radiopharmaceuticals (RPs), trials to control the biobehavior (pharmacokinetics, PK) of RP based on molecular targeting strategy, and application of imaging to personalized medicare. RPs are currently used for imaging diagnosis mainly by positron emission tomography (PET) and single photon emission computed tomography (SPECT), and for treatment of various diseases. Molecular imaging, visualization of PK of RP molecule, is expected to greatly contribute to medicare hereafter. For instance, 123 I-IAMT (3-iodo-alpha-methyl-tyrosine), made resistant to metabolic degradation, has been found to be a selective probe of cerebral transporter (Tp) function of amino acids (AA). Dopamine analogues are under development aiming to diagnosis of dopaminergic function before, during and post therapy of Parkinsonism by such molecular imaging. The diagnostic problem of the distribution of 18 F-fluorodeoxyglucose (FDG) in PET to other normal organs than tumor may be solved by recent active studies of RP post-FDG for AA analogues as an AA Tp probe like 18 F-FAMT (3-fluoro-AMT). RP imaging where its PK in an individual patient can be quantitated, is also applicable to decide the personalized effective, safe dose. Control of RP PK by Tp inhibitor and by serum protein binding replacing agent has been shown possible for 125 I-IAMT in the mouse tumor and for 123 I-IMP (N-isopropyl-p-iodo-amphetamine) in the monkey brain, respectively. Internal RP therapy is effective for cancers without specifying their lesion site. 131 I-iodide is prescribed for thyroid diseases and the diagnostic 123 I-iodide is used for decision of the most appropriate dose in the same patient. Treatment/monitoring use of recent 90 Y-/ 111 In-CD20 antibody anti-cancer assures the safety of patients. Next generation personalized medicare, the targeting confirmative therapy, will be in practice to avoid adverse effect and promote efficacy with therapeutic strategy decided by

  7. Nasoduodenal tube placement: Are two views necessary to confirm position?

    Energy Technology Data Exchange (ETDEWEB)

    Ngo, Anh-Vu; Done, Stephen; Otto, Randolph; Friedman, Seth; Stanescu, A.L. [Seattle Children' s Hospital, Department of Radiology, Seattle, WA (United States)

    2017-09-15

    Nasoduodenal tube (NDT) placement is typically performed at the bedside and two-view abdominal radiographs are usually used to confirm tube position. Anecdotally, in most instances the lateral view is unnecessary and utilizes more than twice the radiation than an anteroposterior (AP) view alone. We hypothesize that NDT location can be determined using only the AP view, with the NDT position determined on two views utilized as the gold standard. A search was performed for all two- or three-view abdominal radiographs from September 2012 to September 2013 with the phrase ''ND tube'' in the reason field of the requisition. These studies were independently reviewed by two radiologists and scored for anatomical tube position in three different scenarios: AP view alone, the lateral view alone, and both views together, with the latter serving as the gold standard. The anatomical scores were subsequently grouped to reflect clinically significant scenarios. Comparative analysis was performed with the original and clinically grouped scores. A total of 102 patients and 306 separate two-view exams were evaluated. Of the 102 patients, 55 had at least two separate exams. Across raters, concordances of AP and lateral scores relative to the gold standard assessment were 88% and 73% for anatomical scores, and 91.5% and 86.4% for clinically grouped data. Trend differences for fewer errors were found with the AP compared to the lateral view. There were statistically significant group differences with a greater number of false-negative errors in the lateral data set. No clear differences were found when comparing AP and lateral ratings for false-positive errors. Upon review of the common errors, we determined a few imaging findings on AP radiographs that can help assess the need for an additional lateral view. A single AP view is sufficient to determine the NDT position in most cases. Two views should be reserved for cases where the NDT position cannot be

  8. Physiotherapy in multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Anna Łuszczyńska

    2015-10-01

    Full Text Available Introduction: Multiple sclerosis (MS is a chronic, progressive, demyelinating disease of the central nervous system. 2.5 million people are affected by MS worldwide; in Poland, the number of patients is approximately 40,000. Patients with multiple sclerosis suffer from a number of symptoms associated with this disease. Aim of the research: To assess the effectiveness of physiotherapy in MS. Material and methods : The study enrolled 25 MS patients aged 27–72 years (including 16 females and 9 males, undergoing 6-week rehabilitation. They were examined twice: before and after rehabilitation. The study used two questionnaires created by the author. Evaluation of the clinical status and disease severity was based on the Kurtzke Expanded Disability Status Scales (EDSS, the Lawton Instrumental Activities of Daily Living (IADL Scale, and the Multiple Sclerosis Impact Scale (MSIS-29. The results were analysed with Student’s t-test and the chi-square (χ 2 test. Results : Statistical analysis showed significant (the level of significance was 0.05 progress in the functional status of the patients after physiotherapy, as evidenced by improved results with respect to the motor efficiency in the Kurtzke Expanded Disability Status Scale (EDSS, the functional assessment in the Lawton Instrumental Activities of Daily Living (IADL Scale, and the influence of MS on patients’ daily life in the Multiple Sclerosis Impact Scale (MSIS-29 seen in the majority of the patients, which confirms a positive impact of the therapy. Conclusions: In the study group, comprehensive rehabilitation had a beneficial influence on the improvement of functional status and the level of motor ability. Physiotherapy turned out to be an extremely effective form of symptomatic treatment of MS patients.

  9. Molecular typing of Leptospira spp. strains isolated from field mice confirms a link to human leptospirosis.

    Science.gov (United States)

    Li, S J; Wang, D M; Zhang, C C; Li, X W; Yang, H M; Tian, K C; Wei, X Y; Liu, Y; Tang, G P; Jiang, X G; Yan, J

    2013-11-01

    In recent years, human leptospirosis has been reported in Jinping and Liping counties, Guizhou province, but the leptospires have never been isolated. To track the source of infection and understand the aetiological characteristics, we performed surveillance for field mice carriage of leptospirosis in 2011. Four strains of leptospire were isolated from Apodemus agrarius. PCR confirmed the four isolates as pathogenic. Multiple-locus variable-number tandem repeat analysis (MLVA) showed that the four strains were closely related to serovar Lai strain 56601 belonging to serogroup Icterohaemorrhagiae, which is consistent with the antibody detection results from local patients. Furthermore, the diversity of leptospiral isolates from different hosts and regions was demonstrated with MLVA. Our results suggest that A. agrarius may be the main carrier of Leptospira in Jinping and Liping counties, and the serogroup Icterohaemorrhagiae serovar may be the epidemic serogroup of Leptospira. This will contribute to the control and prevention of leptospirosis in these localities.

  10. Molecular confirmation of hybridization between Dascyllus reticulatus × Dascyllus aruanus from the Great Barrier Reef

    KAUST Repository

    He, Song

    2017-11-17

    To date, more than 81 species of tropical coral reef fish have been reported to hybridize in nature, spanning multiple families, including the Chaetodontidae, Pomacanthidae, and Labridae. Hybridization, however, is seemingly rare among benthic nesting species that engage in pair spawning, such as the Pomacentridae. Here, we present evidence for the first molecularly confirmed record of hybridization within the genus Dascyllus; D. aruanus and D. reticulatus. Interestingly, although many hybridization events are attributed to peripheral range effects or areas of limited overlap among otherwise allopatric species, this hybrid individual was collected from the northern Great Barrier Reef, centrally located within the distribution ranges of both species. The hybrid exhibited coloration and meristic counts intermediate between D. aruanus and D. reticulatus. Diagnostic genetic markers and subsequent microsatellites analysis confirmed that this individual was a hybrid offspring of D. aruanus and D. reticulatus, with the latter providing the maternal contribution. The occurrence of the D. aruanus × D. reticulatus hybrid on the Great Barrier Reef represents an exception to the otherwise species-specific haplotypes. The nuclear diagnostic marker which was identified during this study could serve as a hybrid indicator and benefit future hybrid investigations for hybridization between these two species.

  11. Risk Factors for Fatal Hyperglycaemia Confirmed by Forensic Postmortem Examination - A Nationwide Cohort in Sweden.

    Directory of Open Access Journals (Sweden)

    Lotta Walz

    Full Text Available The aim of this study was to identify risk factors associated with confirmed fatal hyperglycaemia, which could predispose potentially preventable deaths in individuals on glucose lowering drugs.A retrospective register-based case-control study conducted on a nationwide cohort with individuals who died due to hyperglycaemia as determined by forensic postmortem examination, in Sweden August 2006 to December 2012. Vitreous glucose was used to diagnose hyperglycaemia postmortem. The forensic findings stored in the National Forensic Medicine Database were linked to nationwide registers. Cases that died due to confirmed hyperglycemia with dispensed glucose lowering drugs were identified and living controls with dispensed glucose lowering drugs were randomly selected in the Swedish prescribed drug register and matched on age and sex. Information on comorbidities, dispensed pharmaceuticals, clinical data and socioeconomic factors were obtained for cases and controls. Adjusted multiple logistic regression models were used to identify risk factors associated with fatal hyperglycaemia.During the study period 322 individuals, mostly males (79% with the mean age of 53.9 years (SD.± 14 died due to confirmed hyperglycaemia. Risk factors for fatal hyperglycaemia included; insulin treatment (OR = 4.40; 95%CI,1.96, 9.85, poor glycaemic control (OR = 2.00 95%CI,1.23, 3.27, inadequate refill-adherence before death (OR = 3.87; 95%CI,1.99, 7.53, microvascular disease (OR = 3.26; 95% CI, 1.84, 5.79, psychiatric illness (OR = 2.30; 95% CI,1.32, 4.01, substance abuse (OR = 8.85; 95%CI,2.34, 35.0 and/or living alone (OR = 2.25; 95%CI,1.21, 4.18.Our results demonstrate the importance of clinical attention to poor glycaemic control in subjects with psychosocial problems since it may indicate serious non-adherence, which consequently could lead to fatal hyperglycaemia.

  12. Feature Detection, Characterization and Confirmation Methodology: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Karasaki, Kenzi; Apps, John; Doughty, Christine; Gwatney, Hope; Onishi, Celia Tiemi; Trautz, Robert; Tsang, Chin-Fu

    2007-03-01

    This is the final report of the NUMO-LBNL collaborative project: Feature Detection, Characterization and Confirmation Methodology under NUMO-DOE/LBNL collaboration agreement, the task description of which can be found in the Appendix. We examine site characterization projects from several sites in the world. The list includes Yucca Mountain in the USA, Tono and Horonobe in Japan, AECL in Canada, sites in Sweden, and Olkiluoto in Finland. We identify important geologic features and parameters common to most (or all) sites to provide useful information for future repository siting activity. At first glance, one could question whether there was any commonality among the sites, which are in different rock types at different locations. For example, the planned Yucca Mountain site is a dry repository in unsaturated tuff, whereas the Swedish sites are situated in saturated granite. However, the study concludes that indeed there are a number of important common features and parameters among all the sites--namely, (1) fault properties, (2) fracture-matrix interaction (3) groundwater flux, (4) boundary conditions, and (5) the permeability and porosity of the materials. We list the lessons learned from the Yucca Mountain Project and other site characterization programs. Most programs have by and large been quite successful. Nonetheless, there are definitely 'should-haves' and 'could-haves', or lessons to be learned, in all these programs. Although each site characterization program has some unique aspects, we believe that these crosscutting lessons can be very useful for future site investigations to be conducted in Japan. One of the most common lessons learned is that a repository program should allow for flexibility, in both schedule and approach. We examine field investigation technologies used to collect site characterization data in the field. An extensive list of existing field technologies is presented, with some discussion on usage and limitations

  13. Cosmic Forensics Confirms Gamma-Ray Burst And Supernova Connection

    Science.gov (United States)

    2003-03-01

    Scientists announced today that they have used NASA's Chandra X-ray Observatory to confirm that a gamma-ray burst was connected to the death of a massive star. This result is an important step in understanding the origin of gamma-ray bursts, the most violent events in the present-day universe. "If a gamma-ray burst were a crime, then we now have strong circumstantial evidence that a supernova explosion was at the scene," said Nathaniel Butler of Massachusetts Institute of Technology in Cambridge, lead author of a paper presented today at the meeting of the High Energy Division of the American Astronomical Society. Chandra was able to obtain an unusually long observation (approximately 21 hours) of the afterglow of GRB 020813 (so named because the High-Energy Transient Explorer, HETE, discovered it on August 13, 2002.) A grating spectrometer aboard Chandra revealed an overabundance of elements characteristically dispersed in a supernova explosion. Narrow lines, or bumps, due to silicon and sulfur ions (atoms stripped of most of their electrons) were clearly identified in the X-ray spectrum of GRB 020813. "Our observation of GRB 020813 supports two of the most important features of the popular supra-nova model for gamma-ray bursts," said Butler. "An extremely massive star likely exploded less than two months prior to the gamma-ray burst, and the radiation from the gamma-ray burst was beamed into a narrow cone." An analysis of the data showed that the ions were moving away from the site of the gamma-ray burst at a tenth the speed of light, probably as part of a shell of matter ejected in the supernova explosion. The line features were observed to be sharply peaked, indicating that they were coming from a narrow region of the expanding shell. This implies that only a small fraction of the shell was illuminated by the gamma-ray burst, as would be expected if the burst was beamed into a narrow cone. The observed duration of the afterglow suggests a delay of about 60 days

  14. Experimental verification of carrier multiplication in graphene.

    Science.gov (United States)

    Plötzing, T; Winzer, T; Malic, E; Neumaier, D; Knorr, A; Kurz, H

    2014-09-10

    We report on the first direct experimental observation of carrier multiplication in graphene reaching a multiplication factor of up to 2 and persisting on a picoseconds time scale. Exploiting multicolor pump-probe measurement techniques, the excited nonequilibrium carrier distribution is retrieved on an ultrafast time scale. This provides access to the temporal evolution of the optically excited carrier density and thus allows quantitative conclusions on possible carrier multiplication. Microscopic time- and momentum-resolved calculations on the ultrafast relaxation dynamics of optically excited carriers confirm the observation of carrier multiplication under corresponding experimental conditions, suggesting graphene as a promising material for novel high-efficiency photodetection devices.

  15. Physical Confirmation and Comparative Genomics of the Rat Mammary carcinoma susceptibility 3 Quantitative Trait Locus

    Directory of Open Access Journals (Sweden)

    Saasha Le

    2017-06-01

    Full Text Available Human breast and rat mammary cancer susceptibility are complex phenotypes where complete sets of risk associated loci remain to be identified for both species. We tested multiple congenic rat strains to physically confirm and positionally map rat Mammary carcinoma susceptibility 3 (Mcs3—a mammary cancer resistance allele previously predicted at Rattus norvegicus chromosome 1 (RNO1. The mammary cancer susceptible Wistar Furth (WF strain was the recipient, and the mammary cancer resistant Copenhagen (Cop strain was the RNO1-segment donor for congenics. Inbred WF females averaged 6.3 carcinogen-induced mammary carcinomas per rat. Two WF.Cop congenic strains averaged 2.8 and 3.4 mammary carcinomas per rat, which confirmed Mcs3 as an independently acting allele. Two other WF.Cop congenic strains averaged 6.6 and 8.1 mammary carcinomas per rat, and, thus, did not contain Mcs3. Rat Mcs3 was delimited to 27.8 Mb of RNO1 from rs8149408 to rs105131702 (RNO1:143700228-171517317 of RGSC 6.0/rn6. Human genetic variants with p values for association to breast cancer risk below 10−7 had not been reported for Mcs3 orthologous loci; however, human variants located in Mcs3-orthologous regions with potential association to risk (10−7 < p < 10−3 were listed in some population-based studies. Further, rat Mcs3 contains sequence orthologous to human 11q13/14—a region frequently amplified in female breast cancer. We conclude that Mcs3 is an independently acting mammary carcinoma resistance allele. Human population-based, genome-targeted association studies interrogating Mcs3 orthologous loci may yield novel breast cancer risk associated variants and genes.

  16. Polarisation confirmed

    CERN Multimedia

    Anaïs Schaeffer

    2014-01-01

    The polarisation of photons emitted in the decay of a bottom quark into a strange quark, as predicted by the Standard Model, has just been observed for the first time by the LHCb collaboration. More detailed research is still required to determine the value of this polarisation with precision.   In this LHCb event, K, π and γ are emitted from a B+ → K+π-π+γ decay. This was investigated by the LHCb collaboration in order to study the photon (γ) polarisation.   If we imagine that photons are like little spinning tops which spin around an axis aligned with their direction of propagation, we can identify two types of photons. Those that are “right-handed” turn in the same direction as a corkscrew, and those that are “left-handed” turn in the opposite direction. If for a large number of decays of a given type we can observe an imbalance between the production of right-han...

  17. 49 CFR 40.231 - What devices are used to conduct alcohol confirmation tests?

    Science.gov (United States)

    2010-10-01

    ... Supplies Used in Alcohol Testing § 40.231 What devices are used to conduct alcohol confirmation tests? (a... section are the only devices you may use to conduct alcohol confirmation tests under this part. Note that... use in confirmation testing in the DOT alcohol testing program. (b) To conduct a confirmation test...

  18. Multiple Input - Multiple Output (MIMO) SAR

    Data.gov (United States)

    National Aeronautics and Space Administration — This effort will research and implement advanced Multiple-Input Multiple-Output (MIMO) Synthetic Aperture Radar (SAR) techniques which have the potential to improve...

  19. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether.

    Science.gov (United States)

    Naon, Deborah; Zaninello, Marta; Giacomello, Marta; Varanita, Tatiana; Grespi, Francesca; Lakshminaranayan, Sowmya; Serafini, Annalisa; Semenzato, Martina; Herkenne, Stephanie; Hernández-Alvarez, Maria Isabel; Zorzano, Antonio; De Stefani, Diego; Dorn, Gerald W; Scorrano, Luca

    2016-10-04

    The discovery of the multiple roles of mitochondria-endoplasmic reticulum (ER) juxtaposition in cell biology often relied upon the exploitation of Mitofusin (Mfn) 2 as an ER-mitochondria tether. However, this established Mfn2 function was recently questioned, calling for a critical re-evaluation of Mfn2's role in ER-mitochondria cross-talk. Electron microscopy and fluorescence-based probes of organelle proximity confirmed that ER-mitochondria juxtaposition was reduced by constitutive or acute Mfn2 deletion. Functionally, mitochondrial uptake of Ca 2+ released from the ER was reduced following acute Mfn2 ablation, as well as in Mfn2 -/- cells overexpressing the mitochondrial calcium uniporter. Mitochondrial Ca 2+ uptake rate and extent were normal in isolated Mfn2 -/- liver mitochondria, consistent with the finding that acute or chronic Mfn2 ablation or overexpression did not alter mitochondrial calcium uniporter complex component levels. Hence, Mfn2 stands as a bona fide ER-mitochondria tether whose ablation decreases interorganellar juxtaposition and communication.

  20. Study of 185 diabetic patients with cerebrovascular accident as confirmed on CT

    International Nuclear Information System (INIS)

    Ito, Yasuo; Yanaga, Tatsurou; Nunoi, Kiyohide.

    1988-01-01

    In 185 diabetic patients with cerebrovascular accident (CVA) from 15 institutions, responsible lesions were confirmed on CT. The ratio of men to women was 2:1. Multiple cerebral infarction was seen in 22%. According to the type and lesions of CVA, CVA was classified as cerebral infarction confined to the perforating branch (Group 1), that confined to the cortical branch (Group II), and cerebral hemorrhage (Group III). The common background factors for initial CVA were a history of hypertension, abnormal ECG findings, abnormality in the fundus of the eyes, and 121-199 mmHg/dl of fasting blood sugar in all groups. Groups I and II were characterized by comprising many patients with diabetic retinopathy, proteinuria, and hyperlipemia. In Group I, the patients tended to be young and managed unfavorably, and to have hypertriglyceremia, while patients in Group II were old and managed favorably and had frequently atrial fibrillation. Many patients in Group III had a history of diabetes mellitus over less than 5 years and were not managed for diabetes mellitus and hypertension. Prognosis was the most favorable in Group I. There was no background factor for prognosis in Group III. (Namekawa, K)

  1. Confirmation of the presence of Janicea antiguensis (Chace, 1972 (Decapoda: Barbouriidae in northeastern and eastern Brazil

    Directory of Open Access Journals (Sweden)

    Bruno W. Giraldes

    Full Text Available The barbouriid shrimp Janicea antiguesis (Chace, 1972 is reported from Porto de Galinhas and Tamandaré in Pernambuco and Guarapari in Espírito Santo, Brazil. These records confirm the presence of J. antiguensis in northeastern and eastern Brazil, considerably extending its Brazilian range from Fernando de Noronha to southern Espírito Santo and also representing the first record of this species from mainland coastal reefs. In Brazil, J. antiguensis occurs in or near marine reef caves, typically at depths between 5 and 15 m, and can be most easily observed while scuba diving at night. Colour photographs of J. antiguensis from various Atlantic localities are provided and its colour pattern is compared to that of the closely related Indo-West Pacific barbouriid shrimp, Parhippolyte misticia (Clark, 1989. Some in situ observations are provided for the Porto de Galinhas population of J. antiguensis. Multiple observations of pairs with both individuals brooding embryos at different developmental stages suggest protandric simultaneous hermaphroditism in J. antiguensis.

  2. Comparison of umbilical cord tissue and meconium for the confirmation of in utero drug exposure.

    Science.gov (United States)

    Colby, Jennifer M

    2017-09-01

    Drug screening in neonates is traditionally performed using meconium, but cord tissue has been proposed as an alternative specimen. This study compares the detection of drugs in a large number of paired meconium and umbilical cord tissue samples from subjects at risk of in utero drug exposure. Physician-ordered toxicology results and clinical information were collected in a retrospective review of subject medical records. All toxicology testing was performed by a national reference laboratory using a combination of immunoassays and chromatography-mass spectrometry. The comparison was limited to drugs present in both cord and meconium panels. Overall agreement between cord and meconium ranged from 76% (cannabinoids) to 100% (barbiturates), but Cohen's kappa was umbilical cord tissue and meconium. For the drugs studied here, meconium provides greater sensitivity, and is likely to remain the specimen of choice when sensitivity is of greatest importance. These results can help clinicians, laboratorians, and epidemiologists to (1) select the most appropriate test to confirm a suspected drug exposure and (2) interpret discordant results when testing is performed in multiple matrices. Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  3. Confirmation of MRS/MPC transfer facility sizing using simulation modeling

    International Nuclear Information System (INIS)

    Houston, E.S.; Hadley, J.D.

    1994-01-01

    The Nuclear Waste Policy Act (NWPA) of 1982, as amended, requires the Department of Energy to begin receiving spent nuclear fuel (SNF) from utilities in January 1998. A repository will not be completed in time for the scheduled receipt of SNF. A Monitored Retrievable Storage (MRS) Facility is therefore a feasible solution to bridge the gap between the 1998 date for fuel acceptance and the startup of the repository. SNF will be stored temporarily at the MRS and later retrieved from storage and shipped to the repository. To simplify fuel handling and to standardize components, the multi-purpose canister (MPC) concept was investigated. The MPC would be a sealed, metallic canister containing multiple SNF assemblies in a dry inert environment. MPCs would be placed into different overpacks for transportation, storage, and disposal at the repository. The MRS transfer facility MPC and SNF throughput requirements, assumptions, and operating concepts were used to initially determine the size of the facility and the major equipment contained within the facility. This initial estimate was based on simplified calculation techniques. The adequacy of the design configurations were then confirmed using SLAM simulation modeling software. Modeling incorporates uncertainties in task durations, the effects of equipment reliability, availability of personnel and equipment, and system breakdowns. This paper describes how the model was developed and how it is used to verify the transfer facility size. It also illustrates how problems with the facility design, operational concepts, and staffing are identified with the results of the model

  4. 10 CFR 60.141 - Confirmation of geotechnical and design parameters.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Confirmation of geotechnical and design parameters. 60.141... IN GEOLOGIC REPOSITORIES Performance Confirmation Program § 60.141 Confirmation of geotechnical and..., measurement, testing, and geologic mapping shall be conducted to ensure that geotechnical and design...

  5. 10 CFR 63.132 - Confirmation of geotechnical and design parameters.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Confirmation of geotechnical and design parameters. 63.132... Confirmation of geotechnical and design parameters. (a) During repository construction and operation, a... that geotechnical and design parameters are confirmed and to ensure that appropriate action is taken to...

  6. 49 CFR 40.251 - What are the first steps in an alcohol confirmation test?

    Science.gov (United States)

    2010-10-01

    ... FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Alcohol Confirmation Tests § 40.251 What are the first steps in an alcohol confirmation test? As the BAT for an alcohol confirmation test... 49 Transportation 1 2010-10-01 2010-10-01 false What are the first steps in an alcohol...

  7. 49 CFR 40.255 - What happens next after the alcohol confirmation test result?

    Science.gov (United States)

    2010-10-01

    ... FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Alcohol Confirmation Tests § 40.255 What happens next after the alcohol confirmation test result? (a) After the EBT has printed the result of an alcohol confirmation test, you must, as the BAT, take the following additional steps: (1) Sign...

  8. 10 CFR 26.103 - Determining a confirmed positive test result for alcohol.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Determining a confirmed positive test result for alcohol... Specimens for Testing § 26.103 Determining a confirmed positive test result for alcohol. (a) A confirmed positive test result for alcohol must be declared under any of the following conditions: (1) When the...

  9. 78 FR 10642 - Removal of Confirm Service From the Market-Dominant Product List

    Science.gov (United States)

    2013-02-14

    ... Confirm Service From the Market-Dominant Product List AGENCY: Postal Service TM . ACTION: Notice. SUMMARY... Commission to remove Confirm service from the Mail Classification Schedule's Market-Dominant product list... Regulatory Commission a request to remove Confirm service from the Mail Classification Schedule's Market...

  10. Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis

    Directory of Open Access Journals (Sweden)

    Watts Richard A

    2009-12-01

    Full Text Available Abstract Background The genetic contribution to the aetiology of anti-neutrophil cytoplasmic antibody (ANCA-associated vasculitis (AAV is not well defined. Across different autoimmune diseases some genes with immunomodulatory roles, such as PTPN22, are frequently associated with multiple diseases, whereas specific HLA associations, such as HLA-B27, tend to be disease restricted. We studied ten candidate loci on the basis of their immunoregulatory role and prior associations with type 1 diabetes (T1D. These included PTPN22, CTLA4 and CD226, which have previously been associated with AAV. Methods We genotyped the following 11 SNPs, from 10 loci, in 641 AAV patients using TaqMan genotyping: rs2476601 in PTPN22, rs1990760 in IFIH1, rs3087243 in CTLA4, rs2069763 in IL2, rs10877012 in CYP27B1, rs2292239 in ERBB3, rs3184504 in SH2B3, rs12708716 in CLEC16A, rs1893217 and rs478582 in PTPN2 and rs763361 in CD226. Where possible, we performed a meta-analysis with previous analyses. Results Both CTLA4 rs3087243 and PTPN22 rs2476601 showed association with AAV, P = 6.4 × 10-3 and P = 1.4 × 10-4 respectively. The minor allele (A of CTLA4 rs3087243 is protective (odds ratio = 0.84, whereas the minor allele (A of PTPN22 rs2476601 confers susceptibility (odds ratio = 1.40. These results confirmed previously described associations with AAV. After meta-analysis, the PTPN22 rs2476601 association was further strengthened (combined P = 4.2 × 10-7, odds ratio of 1.48 for the A allele. The other 9 SNPs, including rs763361 in CD226, showed no association with AAV. Conclusion Our study of T1D associated SNPs in AAV has confirmed CTLA4 and PTPN22 as susceptibility loci in AAV. These genes encode two key regulators of the immune response and are associated with many autoimmune diseases, including T1D, autoimmune thyroid disease, celiac disease, rheumatoid arthritis, and now AAV.

  11. Difference between early clinical features of swine origin A H1N1 influenza confirmed and not confirmed infection in Mexico.

    Science.gov (United States)

    Rodríguez-Valero, Monica; Prado Calleros, Hector Manuel; Bravo Escobar, Gerardo Arturo; Valdez Vázquez, Rafael Ricardo; Figueroa Moreno, Rafael; Martínez Montes, Guillermo; Kawa Karasik, Simón

    2012-04-13

    The Swine Origin A H1N1 Influenza Virus (SOIV) pandemic emerged in April 2009 affecting people and health-care systems worldwide. This study examined the differences among the early clinical features presented in confirmed SOIV cases, those who tested negative for SOIV infection, fatalities, and hospitalized cases. We reviewed 1,024 initial medical records of patients presenting with acute respiratory symptoms who attended the respiratory emergency room of a general hospital in Mexico and had a confirmatory test for influenza AH1N1 by RT-PCR from April to December 2009. Out of 1,024 cases, 457 (44%) were men with a mean age of 31±17 years; however, of these, SOIV confirmed cases were younger (26±8, p=0.000). SOIV infection was confirmed in 36% of the patients. Most (%?) cases presented mild infection, 20% of the patients required hospitalization, and 0.09% patients died. Asthma was more frequent in confirmed cases (p=0.028). Presence of COPD, systemic arterial hypertension, and diabetes mellitus was significant in confirmed hospitalized cases. Pulmonary rales, wheezing, and sudden symptom onset were more frequent and statistically significant in confirmed patients. Influenza-like illness was more frequent in confirmed cases (p=0.049).  This study presents one of the largest series of the new SOIV infection confirmed by RT-PCR reported. This infection is frequently mild and affects mainly young adults. Sudden symptoms onset, pulmonary rales, and wheezing are early features of this infection. Asthma, COPD, systemic arterial hypertension, and diabetes mellitus should be identified to identify potentially severe and fatal cases. ILI helps distinguish SOIV infection.

  12. In Australia: Multiple Intelligences in Multiple Settings.

    Science.gov (United States)

    Vialle, Wilma

    1997-01-01

    In Australia, Gardner's multiple-intelligences theory has strongly influenced primary, preschool, and special education. A survey of 30 schools revealed that teachers use two basic approaches: teaching to, and teaching through, multiple intelligences. The first approach might develop children's music skills via playing an instrument. The second…

  13. Elementary school-based influenza vaccination: evaluating impact on respiratory illness absenteeism and laboratory-confirmed influenza.

    Science.gov (United States)

    Kjos, Sonia A; Irving, Stephanie A; Meece, Jennifer K; Belongia, Edward A

    2013-01-01

    Studies of influenza vaccine effectiveness in schools have assessed all-cause absenteeism rather than laboratory-confirmed influenza. We conducted an observational pilot study to identify absences due to respiratory illness and laboratory-confirmed influenza in schools with and without school-based vaccination. A local public health agency initiated school-based influenza vaccination in two Wisconsin elementary schools during October 2010 (exposed schools); two nearby schools served as a comparison group (non-exposed schools). Absences due to fever or cough illness were monitored for 12 weeks. During the 4 weeks of peak influenza activity, parents of absent children with fever/cough illness were contacted and offered influenza testing. Parental consent for sharing absenteeism data was obtained for 937 (57%) of 1,640 students. Fifty-two percent and 28%, respectively, of all students in exposed and non-exposed schools were vaccinated. Absences due to fever or cough illness were significantly lower in the exposed schools during seven of 12 surveillance weeks. Twenty-seven percent of students at exposed schools and 39% at unexposed schools had one or more days of absence due to fever/cough illness (pschools. Detection of laboratory-confirmed influenza in schools was challenging due to multiple consent requirements, difficulty obtaining samples from absent children, and a mild influenza season. School-based influenza vaccination was associated with reduced absenteeism due to fever or cough illness, but not absenteeism for other reasons. Although nonspecific, absence due to fever or cough illness may be a useful surrogate endpoint in school-based studies if identification of laboratory confirmed influenza is not feasible.

  14. Domestic Violence - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Domestic Violence URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Domestic Violence - Multiple Languages To use the sharing features on ...

  15. ALICE Forward Multiplicity Detector

    CERN Multimedia

    Christensen, C

    2013-01-01

    The Forward Multiplicity Detector (FMD) extends the coverage for multiplicity of charge particles into the forward regions - giving ALICE the widest coverage of the 4 LHC experiments for these measurements.

  16. Health Literacy - Multiple Languages

    Science.gov (United States)

    ... Here: Home → Multiple Languages → All Health Topics → Health Literacy URL of this page: https://medlineplus.gov/languages/ ... W XYZ List of All Topics All Health Literacy - Multiple Languages To use the sharing features on ...

  17. Postpartum Depression - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Postpartum Depression URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Postpartum Depression - Multiple Languages To use the sharing features on ...

  18. Dual Diagnosis - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Dual Diagnosis URL of this page: https://medlineplus.gov/ ... V W XYZ List of All Topics All Dual Diagnosis - Multiple Languages To use the sharing features ...

  19. Zika Virus - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Zika Virus URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Zika Virus - Multiple Languages To use the sharing features on ...

  20. Cesarean Section - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Cesarean Section URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Cesarean Section - Multiple Languages To use the sharing features on ...

  1. Child Abuse - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Child Abuse URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Child Abuse - Multiple Languages To use the sharing features on ...

  2. Salmonella Infections - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Salmonella Infections URL of this page: https://medlineplus.gov/ ... V W XYZ List of All Topics All Salmonella Infections - Multiple Languages To use the sharing features ...

  3. Panic Disorder - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Panic Disorder URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Panic Disorder - Multiple Languages To use the sharing features on ...

  4. Rotavirus Infections - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Rotavirus Infections URL of this page: https://medlineplus.gov/ ... V W XYZ List of All Topics All Rotavirus Infections - Multiple Languages To use the sharing features ...

  5. Herbal Medicine - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Herbal Medicine URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Herbal Medicine - Multiple Languages To use the sharing features on ...

  6. Cosmetic Dentistry - Multiple Languages

    Science.gov (United States)

    ... Here: Home → Multiple Languages → All Health Topics → Cosmetic Dentistry URL of this page: https://medlineplus.gov/languages/ ... W XYZ List of All Topics All Cosmetic Dentistry - Multiple Languages To use the sharing features on ...

  7. Oral Cancer - Multiple Languages

    Science.gov (United States)

    ... Are Here: Home → Multiple Languages → All Health Topics → Oral Cancer URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Oral Cancer - Multiple Languages To use the sharing features on ...

  8. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, Mohammad Akbar Hosain

    2014-12-04

    Various examples are provided for generalized internal multiple imaging (GIMI). In one example, among others, a method includes generating a higher order internal multiple image using a background Green\\'s function and rendering the higher order internal multiple image for presentation. In another example, a system includes a computing device and a generalized internal multiple imaging (GIMI) application executable in the computing device. The GIMI application includes logic that generates a higher order internal multiple image using a background Green\\'s function and logic that renders the higher order internal multiple image for display on a display device. In another example, a non-transitory computer readable medium has a program executable by processing circuitry that generates a higher order internal multiple image using a background Green\\'s function and renders the higher order internal multiple image for display on a display device.

  9. Multiple sclerosis - discharge

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000129.htm Multiple sclerosis - discharge To use the sharing features on this ... Your doctor has told you that you have multiple sclerosis (MS). This disease affects the brain and spinal ...

  10. Multiple Endocrine Neoplasia Syndromes

    Science.gov (United States)

    ... switch to the Professional version Home Hormonal and Metabolic Disorders Multiple Endocrine Neoplasia Syndromes Multiple Endocrine Neoplasia Syndromes Types Type 1 disease Type 2A disease Type 2B disease Diagnosis Treatment Resources In This Article Drugs Mentioned In This ...

  11. Multiple System Atrophy (MSA)

    Science.gov (United States)

    Multiple system atrophy (MSA) Overview Multiple system atrophy (MSA) is a rare, degenerative neurological disorder affecting your body's involuntary (autonomic) functions, including blood pressure, breathing, bladder function and muscle ...

  12. Neutron Multiplicity Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Frame, Katherine Chiyoko [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-06-28

    Neutron multiplicity measurements are widely used for nondestructive assay (NDA) of special nuclear material (SNM). When combined with isotopic composition information, neutron multiplicity analysis can be used to estimate the spontaneous fission rate and leakage multiplication of SNM. When combined with isotopic information, the total mass of fissile material can also be determined. This presentation provides an overview of this technique.

  13. Multiple meningiomas CASE SERIES

    African Journals Online (AJOL)

    SA JOURNAL OF RADIOLOGY • June 2006. Abstract. Multiple meningioma is a condition in which ... Post-contrast image showing contrast enhanced right temporal and frontal parasagittal meningiomas. CASE SERIES ... in the formation of multiple, clonally related tumours.2,3,4,8. Gruber et al.6 described a case of multiple ...

  14. On transition in plasma turbulence with multiple scale lengths

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, K.; Spineanu, F.; Vlad, M.O. [National Inst. for Fusion Science, Toki, Gifu (Japan); Itoh, S.-I.; Kawasaki, M. [Kyushu Univ., Research Institute for Applied Mechanics, Kasuga, Fukuoka (Japan)

    2003-05-01

    A statistical theory of plasma turbulence which is composed of multiple-scale fluctuations is examined. Influences of statistical noise and variance of rapidly-changing variable in an adiabatic approximation are investigated. It is confirmed that the contributions of noise and variance remain higher order corrections. Transition rate of the turbulence with multiple scale lengths is obtained under the refined adiabatic approximation. (author)

  15. Multiple cranial neuropathy: a common diagnostic problem.

    Science.gov (United States)

    Garg, R K; Karak, B

    1999-10-01

    Syndrome of multiple cranial palsies is a common clinical problem routinely encountered in neurological practice. Anatomical patterns of cranial nerves involvement help in localizing the lesion. Various infections, malignant neoplasms and autoimmune vasculitis are common disorders leading to various syndromes of multiple cranial nerve palsies. A large number of diffuse neurological disorders (e.g. Gullian-Barre syndrome, myopathies) may also present with syndrome of multiple cranial nerve palsies. Despite extensive biochemical and radiological work-up the accurate diagnosis may not be established. Few such patients represent "idiopathic" variety of multiple cranial nerve involvement and show good response to corticosteroids. Widespread and sequential involvements of cranial nerves frequently suggest possibility of malignant infiltration of meninges, however, confirmation of diagnosis may not be possible before autopsy.

  16. Determination of clinical and demographic predictors of laboratory-confirmed influenza with subtype analysis

    Directory of Open Access Journals (Sweden)

    Woolpert Tabitha

    2012-06-01

    Full Text Available Abstract Background Rapid influenza diagnosis is important for early identification of outbreaks, effective management of high-risk contacts, appropriate antiviral use, decreased inappropriate antibiotic use and avoidance of unnecessary laboratory testing. Given the inconsistent performance of many rapid influenza tests, clinical diagnosis remains integral for optimizing influenza management. However, reliable clinical diagnostic methods are not well-established. This study assesses predictors of influenza, and its various subtypes, in a broad population at the point of care, across age groups, then evaluates the performance of clinical case definitions composed of identified predictors. Methods Respiratory specimens and demographic and clinical data were obtained from 3- to 80-year-old US military family members presenting for care with influenza-like illness (ILI from November 2007 to April 2008. Molecular and virus isolation techniques were used to detect and subtype influenza viruses. Associations between influenza diagnosis and demographic/clinical parameters were assessed by logistic regression, including influenza type and subtype analyses. The predictive values of multiple combinations of identified clinical predictors (case definitions, and the Centers for Disease Control and Prevention (CDC ILI case definition, were estimated. Results Of 789 subjects, 220 (28% had laboratory-confirmed influenza (51 A(H1, 46 A(H3, 19 A(unsubtypeable, 67 B, 1 AB coinfection, with the proportion of influenza A to B cases highest among 6- to 17-year-olds (p = 0.019. Independent predictors of influenza included fever, cough, acute onset, body aches, and vaccination status among 6- to 49-year-olds, only vaccination among 3- to 5-year-olds, and only fever among 50- to 80-year-olds. Among 6- to 49-year-olds, some clinical case definitions were highly sensitive (100.0% or specific (98.6%, but none had both parameters over 60%, though many performed better

  17. A novel CYBB mutation with the first genetically confirmed case of ...

    African Journals Online (AJOL)

    A case of a child with chronic granulomatous disease (CGD) presenting with recurrent mycobacterial infections and invasive Aspergillus fumigatus disease is described. Genetic analysis confirmed X-linked CGD with a novel mutation in exon 10 of the CYBB gene – the first South African report of genetically confirmed CGD.

  18. 30 CFR 203.90 - What is in a fabricator's confirmation report?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is in a fabricator's confirmation report... Reports § 203.90 What is in a fabricator's confirmation report? This report shows you have committed in a... equivalent for unconventionally acquired systems): (a) A copy of the contract(s) under which the fabrication...

  19. 49 CFR 40.253 - What are the procedures for conducting an alcohol confirmation test?

    Science.gov (United States)

    2010-10-01

    ... FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Alcohol Confirmation Tests § 40.253 What are the procedures for conducting an alcohol confirmation test? As the BAT conducting an alcohol... 49 Transportation 1 2010-10-01 2010-10-01 false What are the procedures for conducting an alcohol...

  20. 16 CFR 1633.5 - Prototype pooling and confirmation testing requirements.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Prototype pooling and confirmation testing... Prototype pooling and confirmation testing requirements. (a) Prototype pooling. One or more manufacturers may rely on a qualified prototype produced by another manufacturer or prototype developer provided...

  1. Soundness confirmation through cold test of the system equipment of HTTR

    International Nuclear Information System (INIS)

    Ono, Masato; Shinohara, Masanori; Iigaki, Kazuhiko; Tochio, Daisuke; Nakagawa, Shigeaki; Shimazaki, Yosuke

    2014-01-01

    HTTR was established at the Oarai Research and Development Center of Japan Atomic Energy Agency, for the purpose of the establishment and upgrading of high-temperature gas-cooled reactor technology infrastructure. Currently, it performs a safety demonstration test in order to demonstrate the safety inherent in high-temperature gas-cooled reactor. After the Great East Japan Earthquake, it conducted confirmation test for the purpose of soundness survey of facilities and equipment, and it confirmed that the soundness of the equipment was maintained. After two years from the confirmation test, it has not been confirmed whether the function of dynamic equipment and the soundness such as the airtightness of pipes and containers are maintained after receiving the influence of damage or deterioration caused by aftershocks generated during two years or aging. To confirm the soundness of these facilities, operation under cold state was conducted, and the obtained plant data was compared with confirmation test data to evaluate the presence of abnormality. In addition, in order to confirm through cold test the damage due to aftershocks and degradation due to aging, the plant data to compare was supposed to be the confirmation test data, and the evaluation on abnormality of the plant data of machine starting time and normal operation data was performed. (A.O.)

  2. 77 FR 18305 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

    Science.gov (United States)

    2012-03-27

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation Statistics (BTS), DOT. ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act of... BTS collecting reports on the number of passengers holding confirmed reservations that voluntarily or...

  3. 77 FR 55903 - Confirmation, Portfolio Reconciliation, Portfolio Compression, and Swap Trading Relationship...

    Science.gov (United States)

    2012-09-11

    ... Vol. 77 Tuesday, No. 176 September 11, 2012 Part II Commodity Futures Trading Commission 17 CFR Part 23 Confirmation, Portfolio Reconciliation, Portfolio Compression, and Swap Trading Relationship... FUTURES TRADING COMMISSION 17 CFR Part 23 RIN 3038-AC96 Confirmation, Portfolio Reconciliation, Portfolio...

  4. Laquinimod for multiple sclerosis.

    Science.gov (United States)

    He, Dian; Han, Kai; Gao, Xiangdong; Dong, Shuai; Chu, Lan; Feng, ZhanHui; Wu, Shan

    2013-08-06

    Multiple sclerosis (MS) is a chronic immune-mediated, inflammatory, demyelinating, neurodegenerative disorder of the central nervous system, and it causes major socioeconomic burden for the individual patient and for society. An inflammatory pathology occurs during the early relapsing stage of MS and a neurodegenerative pathology dominates the later progressive stage of the disease. Not all MS patients respond adequately to currently available disease-modifying drugs (DMDs). Alternative MS treatments with new modes of action are required to expand the current options for disease-modifying therapies (DMTs) and to aim for freedom from relapses, inflammatory lesions, disability progression and neurodegeneration. Laquinimod has dual properties of immunomodulation and neuroprotection and is a potentially promising new oral DMD in the treatment of relapsing MS. To assess the effectiveness and safety profile of laquinimod as monotherapy or combination therapy versus placebo or approved DMDs (interferon-β, glatiramer acetate, natalizumab, mitoxantrone, fingolimod, teriflunomide, dimethyl fumarate) for modifying the disease course in patients with MS. The Review Group Trials Search Co-ordinator searched the Cochrane Multiple Sclerosis and Rare Diseases of the Central Nervous System Group Specialised Register which, among other sources, contains trials from CENTRAL (The Cochrane Library 2013, Issue 2), MEDLINE, EMBASE, CINAHL, LILACS, PEDro and Clinical trials registries (29 April 2013). We checked references in identified trials and manually searched the reports (2004 to March 2013) from neurological associations and MS societies. We also communicated with researchers participating in trials on laquinimod and contacted Teva Pharmaceutical Industries. All randomised, double-blind, controlled, parallel group clinical trials (RCTs) with a length of follow-up of at least one year evaluating laquinimod, as monotherapy or combination therapy, versus placebo or approved DMDs for

  5. Mortality associated with laparotomy-confirmed neonatal spontaneous intestinal perforation: a prospective 5-year multicenter analysis.

    Science.gov (United States)

    Fisher, Jeremy G; Jones, Brian A; Gutierrez, Ivan M; Hull, Melissa A; Kang, Kuang Horng; Kenny, Michael; Zurakowski, David; Modi, Biren P; Horbar, Jeffrey D; Jaksic, Tom

    2014-08-01

    Spontaneous intestinal perforation (SIP) has been recognized as a distinct disease entity. This study sought to quantify mortality associated with laparotomy-confirmed SIP and to compare it to mortality of laparotomy-confirmed necrotizing enterocolitis (NEC). Data were prospectively collected on 177,618 very-low-birth-weight (VLBW, 401-1500g) neonates born between January 2006 and December 2010 admitted to US hospitals participating in the Vermont Oxford Network (VON). SIP was defined at laparotomy as a focal perforation of the intestine without features suggestive of NEC or other intestinal abnormalities. The primary outcome was in-hospital mortality. At laparotomy, 2036 (1.1%) neonates were diagnosed with SIP and 4076 (2.3%) with NEC. Neonates with laparotomy-confirmed SIP had higher mortality (19%) than infants without NEC or SIP (5%, P=0.003). However, laparotomy-confirmed SIP patients had significantly lower mortality than those with confirmed NEC (38%, P<0.0001). Mortality in both NEC and SIP groups decreased with increasing birth weight and mortality was significantly higher for NEC than SIP in each birth weight category. Indomethacin and steroid exposure were more frequent in the SIP cohort than the other two groups (P<0.001). In VLBW infants, the presence of laparotomy-confirmed SIP increases mortality significantly. However, laparotomy-confirmed NEC mortality was double that of SIP. This relationship is evident regardless of birth weight. The variant mortality of laparotomy-confirmed SIP versus laparotomy-confirmed NEC highlights the importance of differentiating between these two diseases both for clinical and research purposes. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer.

    Directory of Open Access Journals (Sweden)

    Ursula M Schick

    Full Text Available Chromosomal abnormalities provide clinical utility in the diagnosis and treatment of hematologic malignancies, and may be predictive of malignant transformation in individuals without apparent clinical presentation of a hematologic cancer. In an effort to confirm previous reports of an association between clonal mosaicism and incident hematologic cancer, we applied the anomDetectBAF algorithm to call chromosomal anomalies in genotype data from previously conducted Genome Wide Association Studies (GWAS. The genotypes were initially collected from DNA derived from peripheral blood of 12,176 participants in the Group Health electronic Medical Records and Genomics study (eMERGE and the Women's Health Initiative (WHI. We detected clonal mosaicism in 169 individuals (1.4% and large clonal mosaic events (>2 mb in 117 (1.0% individuals. Though only 9.5% of clonal mosaic carriers had an incident diagnosis of hematologic cancer (multiple myeloma, myelodysplastic syndrome, lymphoma, or leukemia, the carriers had a 5.5-fold increased risk (95% CI: 3.3-9.3; p-value = 7.5×10(-11 of developing these cancers subsequently. Carriers of large mosaic anomalies showed particularly pronounced risk of subsequent leukemia (HR = 19.2, 95% CI: 8.9-41.6; p-value = 7.3×10(-14. Thus we independently confirm the association between detectable clonal mosaicism and hematologic cancer found previously in two recent publications.

  7. Registration of H2O and SiO masers in the Calabash Nebula to confirm the planetary nebula paradigm

    Science.gov (United States)

    Dodson, R.; Rioja, M.; Bujarrabal, V.; Kim, J.; Cho, S. H.; Choi, Y. K.; Youngjoo, Y.

    2018-05-01

    We report on the astrometric registration of very long baseline interferometry images of the SiO and H2O masers in OH 231.8+4.2, the iconic proto-planetary nebula also known as the Calabash nebula, using the Korean VLBI Network and source frequency phase referencing. This, for the first time, robustly confirms the alignment of the SiO masers, close to the asymptotic giant branch star, driving the bilobe structure with the water masers in the outflow. We are able to trace the bulk motions for the H2O masers over the last few decades to be 19 km s-1 and deduce that the age of this expansion stage is 38 ± 2 yr. The combination of this result with the distance allows a full 3D reconstruction and confirms that the H2O masers lie on and expand along the known large-scale symmetry axis and that the outflow is only a few decades old, so mass loss is almost certainly ongoing. Therefore, we conclude that the SiO emission marks the stellar core of the nebular, the H2O emission traces the expansion, and there must be multiple epochs of ejection to drive the macro-scale structure.

  8. Registration of H2O and SiO masers in the Calabash Nebula, to confirm the Planetary Nebula paradigm

    Science.gov (United States)

    Dodson, R.; Rioja, M.; Bujarrabal, V.; Kim, J.; Cho, SH; Choi, YK; Youngjoo, Y.

    2018-01-01

    We report on the astrometric registration of VLBI images of the SiO and H2O masers in OH 231.8+4.2, the iconic Proto-Planetary Nebula also known as the Calabash nebula, using the KVN and Source/Frequency Phase Referencing. This, for the first time, robustly confirms the alignment of the SiO masers, close to the AGB star, driving the bi-lobe structure with the water masers in the out-flow. We are able to trace the bulk motions for the H2O masers over the last few decades to be 19 km s-1 and deduce that the age of this expansion stage is 38±2 years. The combination of this result with the distance allows a full 3D reconstruction, and confirms that the H2O masers lie on and expand along the known large-scale symmetry axis and that the outflow is only a few decades old, so mass loss is almost certainly on-going. Therefore we conclude that the SiO emission marks the stellar core of the nebular, the H2O emission traces the expansion, and that there must be multiple epochs of ejection to drive the macro-scale structure.

  9. An experimental genetic system using Berberis vulgaris confirms sexual recombination in Puccinia striiformis

    DEFF Research Database (Denmark)

    Rodriguez Algaba, Julian; Walter, Stephanie; Sørensen, Chris Khadgi

    , the use of B. vulgaris plants originating from nature reserves in Sweden and Denmark proved to be successful for infection and selfing a European Pst isolate in the Danish laboratory in 2013. The progeny isolates in the S1 generation were genotyped with microsatellite markers to confirm parental origin...... and to study genotypic diversity. The markers confirmed the parental origin and markers that were heterozygous in the parent generally segregated in the S1 progenies. A largest number of multilocus genotypes observed among the progeny isolates confirmed successful sexual recombination. Segregation...

  10. Prediction of invasive breast cancer using shear-wave elastography in patients with biopsy-confirmed ductal carcinoma in situ.

    Science.gov (United States)

    Bae, Jae Seok; Chang, Jung Min; Lee, Su Hyun; Shin, Sung Ui; Moon, Woo Kyung

    2017-01-01

    To investigate whether mass stiffness measured by shear-wave elastography (SWE) can predict the histological upgrade of ductal carcinoma in situ (DCIS) confirmed through ultrasound (US)-guided core needle biopsy (CNB). The institutional review board approved this study and informed consent was waived. A database search revealed 120 biopsy-confirmed DCIS in patients who underwent B-mode US and SWE prior to surgery. Clinicopathologic results, B-mode findings, size on US, and mean and maximum elasticity values on SWE were recorded. Associations between upgrade to invasive cancer and B-mode US findings, SWE information, and clinical variables were assessed using univariate, multivariate logistic regression, and multiple linear regression analysis. The overall upgrade rate was 41.7 % (50/120). Mean stiffness value (P = .014) and mass size (P = .001) were significantly correlated with histological upgrade. The optimal cut-off value of mean stiffness value, yielding the maximal sum of sensitivity and specificity, was 70.7 kPa showing sensitivity of 72 % and specificity of 65.7 % for detecting invasiveness. Qualitative elasticity colour scores were significantly correlated with the histological upgrade, mammographic density, and B-mode category (P < .04). Mean stiffness values evaluated through SWE can be utilized as a preoperative predictor of histological upgrade to invasive cancer in DCIS confirmed at US-guided needle biopsy. • Higher stiffness values were noted in invasive cancer than DCIS. • Qualitative SWE colour scores significantly correlated with the histological upgrade. • Qualitative SWE colour scores had excellent interobserver agreement.

  11. Multiple dimensions of performance

    NARCIS (Netherlands)

    Torenvlied, René

    2013-01-01

    This presentation considers the multiple dimensions of performance in performance studies, and potentially contradicting effects of different management strategies on separate indicators of performance

  12. Achondroplasia and multiple-suture craniosynostosis.

    Science.gov (United States)

    Albino, Frank P; Wood, Benjamin C; Oluigbo, Chima O; Lee, Angela C; Oh, Albert K; Rogers, Gary F

    2015-01-01

    Genetic mutations in the fibroblast growth factor receptor 3 gene may lead to achondroplasia or syndromic forms of craniosynostosis. Despite sharing a common genetic basis, craniosynostosis has rarely been described in cases of confirmed achondroplasia. We report an infant with achondroplasia who developed progressive multiple-suture craniosynostosis to discuss the genetic link between these clinical entities and to describe the technical challenges associated with the operative management.

  13. 78 FR 21045 - Confirmation, Portfolio Reconciliation, Portfolio Compression, and Swap Trading Relationship...

    Science.gov (United States)

    2013-04-09

    ... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 23 RIN 3038-AC96 Confirmation, Portfolio Reconciliation, Portfolio Compression, and Swap Trading Relationship Documentation Requirements for Swap Dealers..., portfolio compression, and swap trading relationship documentation for Swap Dealers and Major Swap...

  14. Infection by Streptococcus pneumoniae in children with or without radiologically confirmed pneumonia

    Directory of Open Access Journals (Sweden)

    Dafne C. Andrade

    2018-01-01

    Conclusions: Among children with clinical diagnosis of community‐acquired pneumonia submitted to chest radiograph, those with radiologically confirmed pneumonia present a higher rate of infection by S. pneumoniae when compared with those with a normal chest radiograph.

  15. Design of a multiplex PCR assay for the simultaneous detection and confirmation of Neisseria gonorrhoeae.

    LENUS (Irish Health Repository)

    O'Callaghan, Isabelle

    2010-05-01

    To improve the detection of Neisseria gonorrhoeae by designing a multiplex PCR assay using two N gonorrhoeae-specific genes as targets, thereby providing detection and confirmation of a positive result simultaneously.

  16. Miscarriage after sonographic confirmation of an ongoing pregnancy in women with moderate and severe obesity.

    LENUS (Irish Health Repository)

    O'Dwyer, Vicky

    2012-01-01

    To compare the incidence of spontaneous miscarriage in women with moderate to severe obesity to that in women with a normal BMI after sonographic confirmation of the foetal heart rate in the first trimester.

  17. [Confirming Indicators of Qualitative Results by Chromatography-mass Spectrometry in Biological Samples].

    Science.gov (United States)

    Liu, S D; Zhang, D M; Zhang, W; Zhang, W F

    2017-04-01

    Because of the exist of complex matrix, the confirming indicators of qualitative results for toxic substances in biological samples by chromatography-mass spectrometry are different from that in non-biological samples. Even in biological samples, the confirming indicators are different in various application areas. This paper reviews the similarities and differences of confirming indicators for the analyte in biological samples by chromatography-mass spectrometry in the field of forensic toxicological analysis and other application areas. These confirming indicators include retention time (RT), relative retention time (RRT), signal to noise (S/N), characteristic ions, relative abundance of characteristic ions, parent ion-daughter ion pair and abundance ratio of ion pair, etc. Copyright© by the Editorial Department of Journal of Forensic Medicine.

  18. CONFIRMATION OF THE PRESENCE OF RIPARIA RIPARIA IN ITE WETLANDS, SOUTHWEST OF PERU

    OpenAIRE

    Vizcarra, Jhonson

    2011-01-01

    The presence of Riparia riparia (Linnaeus, 1758) in Ite Wetlands is confirmed. Two individuals were observed in January 2011. This record occurs 13 years after the first mention of its presence in these wetlands.

  19. Confirmation of vinyl chloride in foods by conversion to 1-chloro-1,2-dibromoethane.

    Science.gov (United States)

    Williams, D T

    1976-01-01

    A semiquantitative method has been developed for the confirmation of vinyl chloride (VC) in foodstuffs. The VC was brominated to give 1-chloro-1,2-dibromoethane which was analyzed by gas-liquid chromatography, using an electron capture detector. The yield of 1-chloro-1,2-dibromoethane varied between 40 and 55%, which permitted a lower limit of confirmation of VC of 15 ppb for vinegar and sherry and 50 ppb for peanut oil.

  20. The 'Eco Swiss’ Doctrine Con-firmed in Principle in Danish Law

    DEFF Research Database (Denmark)

    Bergqvist, Christian; Christensen, Laurits Peder Schmidt

    2016-01-01

    In a January 2016 ruling the Danish Supreme Court rejected the argument that a 2011 arbitration award infringed competition law and therefore should be set aside but confirmed in principle the ability to require this.......In a January 2016 ruling the Danish Supreme Court rejected the argument that a 2011 arbitration award infringed competition law and therefore should be set aside but confirmed in principle the ability to require this....

  1. Updating OSHA standards based on national consensus standards. final rule; confirmation of effective date.

    Science.gov (United States)

    2008-03-14

    OSHA is confirming the effective date of its direct final rule that revises a number of standards for general industry that refer to national consensus standards. The direct final rule states that it would become effective on March 13, 2008 unless OSHA receives significant adverse comment on these revisions by January 14, 2008. OSHA received no adverse comments by that date and, therefore, is confirming that the rule will become effective on March 13, 2008.

  2. Trust and confirmation in a gynecologic examination situation: a critical incident technique analysis.

    Science.gov (United States)

    Wendt, Eva; Fridlund, Bengt; Lidell, Evy

    2004-12-01

    Gynecologic examination is a common measure in reproductive health care. Many women experience the examination as a more or less negative event, with shortcomings in the examiner's behavior. The aim of the study was to describe, in terms of critical incidences, women's experiences concerning the personnel's behavior in the situation of gynecologic examination. The informants were strategically chosen and consisted of 30 Swedish women between the ages of 18-82 years old. The data collection method was qualitative research interviews analyzed by critical incident technique. The result consisted of 30 subcategories, five categories, and two main areas - trust and confirmation. The personnel enabled trust when they promoted participation, created confidence, and were supportive. The opposite behavior contributed to the lack of trust. Confirmation described behavior that confirmed, respectively, did not confirm the women. This was shown through the presence or lack of respect and engagement. The personnel's positive behavior enabled trust and confirmed the women as individuals, while negative behavior was decisive in an unfavorable way. A complexity of patterns of knowing in nursing was identified. Participation through information that contributed to trust was important and amounted to one fourth of the incidents in the material. Respect and engagement, which confirmed the women, facilitated a positive caring relationship. The examination situation can be improved through reflection of the personnel's own behavior and further research about women's own experiences.

  3. Are supine chest and abdominal radiographs the best way to confirm PICC placement in neonates?

    Science.gov (United States)

    Sneath, Nicole

    2010-01-01

    Peripherally inserted central catheters (PICCs) are commonly used in NICUs. Although they have many benefits, they also have many potential complications. Confirming catheter tip position is essential to decreasing complications, but the best method to achieve confirmation is unclear. Literature review for studies that address line position confirmation to assist health care providers in evaluating the available research and to identify gaps in the literature. A literature search of four major databases followed by an ancestry approach was performed. Articles reviewed specifically discuss PICC lines and PICC line placement confirmation. Data on confirming PICC placement were lacking. Fluoroscopic placement is ideal, but cannot be done at the bedside and is costly. Supine chest radiograph is the most widely used method and is convenient, but when line tip position is unclear, contrast or ultrasound confirmation can be used. When PICC lines are placed in the saphenous vein, infants may benefit from supine and lateral abdominal radiographs to ensure placement in the inferior vena cava. More studies are needed to generalize findings. PICC line tips should be located in the superior vena cava or inferior vena cava close to the junction with the right atrium (0.5-1 cm outside of the cardiac chambers in premature infants and 1-2 cm outside of the cardiac chambers in larger infants). Arm position is very important when performing radiographs for placement because movement of the arm can cause migration of the catheter. There is also significant inter-observer variability when identifying line tip position.

  4. Teriflunomide for multiple sclerosis.

    Science.gov (United States)

    He, Dian; Zhang, Chao; Zhao, Xia; Zhang, Yifan; Dai, Qingqing; Li, Yuan; Chu, Lan

    2016-03-22

    This is an update of the Cochrane review "Teriflunomide for multiple sclerosis" (first published in The Cochrane Library 2012, Issue 12).Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system. It is clinically characterized by recurrent relapses or progression, or both, often leading to severe neurological disability and a serious decline in quality of life. Disease-modifying therapies (DMTs) for MS aim to prevent occurrence of relapses and disability progression. Teriflunomide is a pyrimidine synthesis inhibitor approved by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) as a DMT for adults with relapsing-remitting MS (RRMS). To assess the absolute and comparative effectiveness and safety of teriflunomide as monotherapy or combination therapy versus placebo or other disease-modifying drugs (DMDs) (interferon beta (IFNβ), glatiramer acetate, natalizumab, mitoxantrone, fingolimod, dimethyl fumarate, alemtuzumab) for modifying the disease course in people with MS. We searched the Cochrane Multiple Sclerosis and Rare Diseases of the CNS Group Specialised Trials Register (30 September 2015). We checked reference lists of published reviews and retrieved articles and searched reports (2004 to September 2015) from the MS societies in Europe and America. We also communicated with investigators participating in trials of teriflunomide and the pharmaceutical company, Sanofi-Aventis. We included randomized, controlled, parallel-group clinical trials with a length of follow-up of one year or greater evaluating teriflunomide, as monotherapy or combination therapy, versus placebo or other approved DMDs for people with MS without restrictions regarding dose, administration frequency and duration of treatment. We used the standard methodological procedures of Cochrane. Two review authors independently assessed trial quality and extracted data. Disagreements were discussed and resolved by consensus among

  5. Constraining Multiple Grammars

    Science.gov (United States)

    Hopp, Holger

    2014-01-01

    This article offers the author's commentary on the Multiple Grammars (MG) language acquisition theory proposed by Luiz Amaral and Tom Roeper in the present issue. Multiple Grammars advances the claim that optionality is a constitutive characteristic of any one grammar, with interlanguage grammars being perhaps the clearest examples of a…

  6. [Kahler's disease. Multiple myeloma

    NARCIS (Netherlands)

    Dieleman, F.J.; Dekker, A.W.

    2007-01-01

    Kahler's disease, multiple myeloma, is a malignant condition of unbridled multiplication of plasma cells in bone marrow. Clinical features are anaemia, pain in the affected bones, spontaneous bone fractures and increased infection susceptibility. In the final stage of the disease severe renal

  7. Assessing Children's Multiplicative Thinking

    Science.gov (United States)

    Hurst, Chris; Hurrell, Derek

    2016-01-01

    Multiplicative thinking is a "big idea" of mathematics that underpins much of the mathematics learned beyond the early primary school years. This paper reports on a current study that utilises an interview tool and a written quiz to gather data about children's multiplicative thinking. The development of the tools and some of the…

  8. Multiple Frequency Parametric Sonar

    Science.gov (United States)

    2015-09-28

    300003 1 MULTIPLE FREQUENCY PARAMETRIC SONAR STATEMENT OF GOVERNMENT INTEREST [0001] The invention described herein may be manufactured and...a method for increasing the bandwidth of a parametric sonar system by using multiple primary frequencies rather than only two primary frequencies...2) Description of Prior Art [0004] Parametric sonar generates narrow beams at low frequencies by projecting sound at two distinct primary

  9. Brain Tumors - Multiple Languages

    Science.gov (United States)

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Brain Tumors URL of this page: https://medlineplus.gov/ ... V W XYZ List of All Topics All Brain Tumors - Multiple Languages To use the sharing features on this page, ...

  10. Brain Diseases - Multiple Languages

    Science.gov (United States)

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Brain Diseases URL of this page: https://medlineplus.gov/ ... V W XYZ List of All Topics All Brain Diseases - Multiple Languages To use the sharing features on this page, ...

  11. Suicide and multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E N; Stenager, Egon; Koch-Henriksen, Nils

    1992-01-01

    In a nationwide investigation the risk of death by suicide for patients with multiple sclerosis (MS) was assessed using records kept at the Danish Multiple Sclerosis Registry (DMSR) and the Danish National Register of Cause of Death. The investigation covers all MS patients registered with DSMR...

  12. Applying Multiple Intelligences

    Science.gov (United States)

    Christodoulou, Joanna A.

    2009-01-01

    The ideas of multiple intelligences introduced by Howard Gardner of Harvard University more than 25 years ago have taken form in many ways, both in schools and in other sometimes-surprising settings. The silver anniversary of Gardner's learning theory provides an opportunity to reflect on the ways multiple intelligences theory has taken form and…

  13. ALICE Photon Multiplicity Detector

    CERN Multimedia

    Nayak, T

    2013-01-01

    Photon Multiplicity Detector (PMD) measures the multiplicity and spatial distribution of photons in the forward region of ALICE on a event-by-event basis. PMD is a pre-shower detector having fine granularity and full azimuthal coverage in the pseudo-rapidity region 2.3 < η < 3.9.

  14. Onychomycosis: a critical study of techniques and criteria for confirming the etiologic significance of nondermatophytes.

    Science.gov (United States)

    Summerbell, Richard C; Cooper, Elizabeth; Bunn, Ursula; Jamieson, Frances; Gupta, Aditya K

    2005-02-01

    Nondermatophytic filamentous fungi (NDF) other than Scytalidium species are variously said to cause between 0 and 50% of all toenail onychomycoses, though most estimates are in the 2-5% range. Due to the difficulty of obtaining 'gold standard' control data for comparison, the accuracy of many laboratory evaluation processes used to deal with potential NDF onychomycoses has never been rigorously measured, thus allowing use of differing interpretations of the significance of cultures. To allow valid comparison of these procedures and interpretations, a large series of patients who declined treatment were sampled on multiple occasions from all apparently onychomycotic toenails until adequate certainty had been attained that all etiologic agents had been isolated and, where necessary, confirmed as etiologic via consistent repeated isolation. This information was used to evaluate results that had been obtained in the initial direct microscopy and culture studies for the same patient population, as such results are strongly relied on in routine diagnosis. Direct microscopy (KOH) was found to be 73.8% sensitive for dermatophytes and 67.2% sensitive for proven etiologic NDF (difference not significant). Culture of the initial specimen coincidentally had a sensitivity of 74.6% for both fungal groups. KOH and culture in tandem were 83.9% sensitive for indicating fungal etiology based on the first specimen. Different evaluative frameworks currently used to interpret NDF isolations were contrasted. The 'classic' evaluation procedure, in which all NDF considered etiologic must be isolated from at least two successive nail specimens, at least one of which must be microscopic positive for compatible fungal filaments, had a sensitivity of 59.5% but a specificity of 100% for true NDF infections and mixed NDF/dermatophyte infections. The most widely used 'simple association' evaluation criterion, in which NDF outgrowth is considered etiologic whenever direct microscopy is positive

  15. Preliminary Analysis of Remote Monitoring and Robotic Concepts for Performance Confirmation

    International Nuclear Information System (INIS)

    McAffee, D.A.

    1997-01-01

    As defined in 10 CFR Part 60.2, Performance Confirmation is the ''program of tests, experiments and analyses which is conducted to evaluate the accuracy and adequacy of the information used to determine with reasonable assurance that the performance objectives for the period after permanent closure will be met''. The overall Performance Confirmation program begins during site characterization and continues up to repository closure. The main purpose of this document is to develop, explore and analyze initial concepts for using remotely operated and robotic systems in gathering repository performance information during Performance Confirmation. This analysis focuses primarily on possible Performance Confirmation related applications within the emplacement drifts after waste packages have been emplaced (post-emplacement) and before permanent closure of the repository (preclosure). This will be a period of time lasting approximately 100 years and basically coincides with the Caretaker phase of the project. This analysis also examines, to a lesser extent, some applications related to Caretaker operations. A previous report examined remote handling and robotic technologies that could be employed during the waste package emplacement phase of the project (Reference 5.1). This analysis is being prepared to provide an early investigation of possible design concepts and technical challenges associated with developing remote systems for monitoring and inspecting activities during Performance Confirmation. The writing of this analysis preceded formal development of Performance Confirmation functional requirements and program plans and therefore examines, in part, the fundamental Performance Confirmation monitoring needs and operating conditions. The scope and primary objectives of this analysis are to: (1) Describe the operating environment and conditions expected in the emplacement drifts during the preclosure period. (Presented in Section 7.2). (2) Identify and discuss the

  16. Elementary school-based influenza vaccination: evaluating impact on respiratory illness absenteeism and laboratory-confirmed influenza.

    Directory of Open Access Journals (Sweden)

    Sonia A Kjos

    Full Text Available BACKGROUND: Studies of influenza vaccine effectiveness in schools have assessed all-cause absenteeism rather than laboratory-confirmed influenza. We conducted an observational pilot study to identify absences due to respiratory illness and laboratory-confirmed influenza in schools with and without school-based vaccination. METHODS: A local public health agency initiated school-based influenza vaccination in two Wisconsin elementary schools during October 2010 (exposed schools; two nearby schools served as a comparison group (non-exposed schools. Absences due to fever or cough illness were monitored for 12 weeks. During the 4 weeks of peak influenza activity, parents of absent children with fever/cough illness were contacted and offered influenza testing. RESULTS: Parental consent for sharing absenteeism data was obtained for 937 (57% of 1,640 students. Fifty-two percent and 28%, respectively, of all students in exposed and non-exposed schools were vaccinated. Absences due to fever or cough illness were significantly lower in the exposed schools during seven of 12 surveillance weeks. Twenty-seven percent of students at exposed schools and 39% at unexposed schools had one or more days of absence due to fever/cough illness (p<0.0001. There was no significant difference in the proportion of students absent for other reasons (p = 0.23. During the 4 week period of influenza testing, respiratory samples were obtained for 68 (42% of 163 episodes of absence due to fever or cough illness. Influenza was detected in 6 students; 3 attended exposed schools. CONCLUSIONS: Detection of laboratory-confirmed influenza in schools was challenging due to multiple consent requirements, difficulty obtaining samples from absent children, and a mild influenza season. School-based influenza vaccination was associated with reduced absenteeism due to fever or cough illness, but not absenteeism for other reasons. Although nonspecific, absence due to fever or cough

  17. Smoldering multiple myeloma risk factors for progression

    DEFF Research Database (Denmark)

    Sørrig, Rasmus; Klausen, Tobias W; Salomo, Morten

    2016-01-01

    Several risk scores for disease progression in Smoldering Multiple Myeloma (SMM) patients have been proposed, however, all have been developed using single center registries. To examine risk factors for time to progression (TTP) to Multiple Myeloma (MM) for SMM we analyzed a nationwide population......-based cohort of 321 newly diagnosed SMM patients registered within the Danish Multiple Myeloma Registry between 2005 and 2014. Significant univariable risk factors for TTP were selected for multivariable Cox regression analyses. We found that both an M-protein ≥ 30g/l and immunoparesis significantly influenced......-high risk of transformation to MM. Using only immunoparesis and M-protein ≥ 30g/l, we created a scoring system to identify low, intermediate and high risk SMM. This first population-based study of SMM patients confirms that an M-protein ≥ 30g/l and immunoparesis remain important risk factors for progression...

  18. A multiplicity logic unit

    International Nuclear Information System (INIS)

    Bialkowski, J.; Moszynski, M.; Zagorski, A.

    1981-01-01

    The logic diagram principle of operation and some details of the design of the multiplicity logic unit are presented. This unit was specially designed to fulfil the requirements of a multidetector arrangement for gamma-ray multiplicity measurements. The unit is equipped with 16 inputs controlled by a common coincidence gate. It delivers a linear output pulse with the height proportional to the multiplicity of coincidences and logic pulses corresponding to 0, 1, ... up to >= 5-fold coincidences. These last outputs are used to steer the routing unit working with the multichannel analyser. (orig.)

  19. Hadron multiplicities at COMPASS

    CERN Document Server

    Du Fresne Von Hohenesche, Nicolas

    2014-01-01

    Quark fragmentation functions (FF) D h q ( z ; Q 2 ) describe final-state hadronisation of quarks q into hadrons h . The FFs can be extracted from hadron multiplicities produced in semi-inclusive deep inelastic scattering. The COMPASS collaboration has recently measured charged hadron multiplicities for identified pions and kaons using a 160 GeV/c muon beam impinging on an isoscalar LiD target. The data cover a large kinematical range and provide an important input for global QCD analyses of world data at NLO, aiming at the determination of FFs. The latest results from COMPASS on pion multiplicities and pion fragmentation functions will be discussed.

  20. Exploring Selective Exposure and Confirmation Bias as Processes Underlying Employee Work Happiness: An Intervention Study.

    Science.gov (United States)

    Williams, Paige; Kern, Margaret L; Waters, Lea

    2016-01-01

    Employee psychological capital (PsyCap), perceptions of organizational virtue (OV), and work happiness have been shown to be associated within and over time. This study examines selective exposure and confirmation bias as potential processes underlying PsyCap, OV, and work happiness associations. As part of a quasi-experimental study design, school staff (N = 69) completed surveys at three time points. After the first assessment, some staff (n = 51) completed a positive psychology training intervention. Results of descriptive statistics, correlation, and regression analyses on the intervention group provide some support for selective exposure and confirmation bias as explanatory mechanisms. In focusing on the processes through which employee attitudes may influence work happiness this study advances theoretical understanding, specifically of selective exposure and confirmation bias in a field study context.

  1. The consistency principle in interpersonal communication: consequences of preference confirmation and disconfirmation in collective decision making.

    Science.gov (United States)

    Mojzisch, Andreas; Kerschreiter, Rudolf; Faulmüller, Nadira; Vogelgesang, Frank; Schulz-Hardt, Stefan

    2014-06-01

    Interpersonal cognitive consistency is a driving force in group behavior. In this article, we propose a new model of interpersonal cognitive consistency in collective decision making. Building on ideas from the mutual enhancement model (Wittenbaum, Hubbell, & Zuckerman, 1999), we argue that group members evaluate one another more positively when they mention information confirming each other's preferences instead of information disconfirming these preferences. Furthermore, we argue that this effect is mediated by perceived information quality: Group members evaluate one another more positively when they mention information confirming each other's preferences because they perceive this information to be more important and accurate than information disconfirming each other's preferences. Finally, we hypothesize that group members who communicate information confirming each other's preferences receive positive feedback for doing so, which, in turn, leads group members to mention even more of this information. The results of 3 studies with pseudo and face-to-face interacting dyads provide converging support for our model.

  2. Improving the patient experience with real-time PICC placement confirmation.

    Science.gov (United States)

    Bidgood, Claire

    Peripherally inserted central catheters (PICCs) are now widely used in health care. The use of ultrasound and the micro introducer set have led to an increase in successful insertion rates. However, malposition can still be a problem. This can lead to delays in treatment, increase in procedure time and repeated chest X-rays as well as placement failure. Evolving technologies mean that these challenges can now be overcome. This article describes how a tracking and tip confirmation system (Sherlock 3CG Tip Confirmation System, CR Bard) was used to improve the patient experience during PICC placements by preventing malposition and delays in the start of treatment. Of 88 PICCs placed with the system, all were in an acceptable position when confirmed by chest X-ray and therefore none required any further adjustments post insertion.

  3. Accuracy of Intravenous Electrocardiography Confirmation of Peripherally Inserted Central Catheter for Parenteral Nutrition.

    Science.gov (United States)

    Mundi, Manpreet S; Edakkanambeth Varayil, Jithinraj; McMahon, Megan T; Okano, Akiko; Vallumsetla, Nishanth; Bonnes, Sara L; Andrews, James C; Hurt, Ryan T

    2016-04-01

    Parenteral nutrition (PN) is a life-saving therapy for patients with intestinal failure. Safe delivery of hyperosmotic solution requires a central venous catheter (CVC) with tip in the lower superior vena cava (SVC) or at the SVC-right atrium (RA) junction. To reduce cost and delay in use of CVC, new techniques such as intravascular electrocardiogram (ECG) are being used for tip confirmation in place of chest x-ray (CXR). The present study assessed for accuracy of ECG confirmation in home PN (HPN). Records for all patients consulted for HPN from December 17, 2014, to June 16, 2015, were reviewed for patient demographics, diagnosis leading to HPN initiation, and ECG and CXR confirmation. CXRs were subsequently reviewed by a radiologist to reassess location of the CVC tip and identify those that should be adjusted. Seventy-three patients were eligible, and after assessment for research authorization and postplacement CXR, 17 patients (30% male) with an age of 54 ± 14 years were reviewed. In all patients, postplacement intravascular ECG reading stated tip in the SVC. However, based on CXR, the location of the catheter tip was satisfactory (low SVC or SVC-RA junction) in 10 of 17 patients (59%). Due to the high osmolality of PN, CVC tip location is of paramount importance. After radiology review of CXR, we noted that 7 of 17 (41%) peripherally inserted central catheter lines were in an unsatisfactory position despite ECG confirmation. With current data available, intravenous ECG confirmation should not be used as the sole source of tip confirmation in patients receiving HPN. © 2016 American Society for Parenteral and Enteral Nutrition.

  4. Predictors of HIV/AIDS confirmation and differences by guardian status in HIV+ adolescents in Jamaica.

    Science.gov (United States)

    Pilgrim, N; Kershaw, T; Pierre, R B; Moore, J; Palmer, P; Davis, D; Christie, C D C

    2008-06-01

    Approximately 25% of the cumulative AIDS cases in Jamaica involve adolescents and young adults. However the lives of adolescents living with HIV within Jamaica and the Caribbean have been understudied. (1) To describe the sociodemographic characteristics of HIV+ Jamaican adolescents who have ever been a part of the Kingston Paediatric/Perinatal HIV Programme (KPAIDS) from September 1, 2002 to August 31, 2006 (2). To identify predictors of HIV/AIDS confirmation as well as factors associated or uniquely present in these adolescents by their guardian status. Seventy-two HIV+ adolescents, ages 10-19 years, were included. Factors studied included demographics as well as time to and time between HIV and AIDS confirmation. Data were analyzed by bivariate and multivariate statistics. The mean age of the adolescents was 12.6 +/- 2.8 years with slightly more males (52.8%) in the programme. There were equal proportions of adolescents living with HIV as with AIDS (43.1%). There were equal proportions who were lost to follow-up or deceased (8.3%). Twenty-two of them lived with parents, 25 with guardians and 18 in residential institutions. The primary mode of transmission was perinatal infection (68.1%), followed by sexual (20.8%), blood transfusion (2.9%) and unknown (8.3%). The mean time from HIV exposure to HIV confirmation and AIDS confirmation in mother-to-child transmission (MTCT) cases were 8.0 +/- 2.9 years and 9.6 +/- 3.3 years, respectively. In the multivariate analysis model, age and gender were significant in predicting time from HIV exposure to HIV confirmation. The majority of HIV-positive adolescents reside with parents and guardians and this might indicate support in spite of stigma and discrimination. However; the mean time to HIV confirmation in MTCT cases is quite long and must be reduced.

  5. How value-glamour investors use financial information: UK evidence of investor's confirmation bias

    OpenAIRE

    Doung, C.; Pescetto, G.; Santamaria, D.

    2014-01-01

    The paper investigates investor’s behaviour in the context of value–glamour investing and fundamental analysis, and provides a direct test of the confirmation bias by bringing together the evidence from several strands of literature into a well-defined framework of investor behaviour. The empirical evidence presented is in line with a model of\\ud investor’s asymmetric reaction to good and bad news due to confirmation bias. Pessimistic value investors typically under-react to good financial in...

  6. Confirmation of eradication of Helicobacter pylori infection by 14C-urea breath test

    International Nuclear Information System (INIS)

    Pathak, C.M.; Bhasin, D.K.; Sharma, B.C.; Roy, P.; Vaiphei, K.

    1998-01-01

    Helicobacter pylori (H. pylori) is a potent urease producer, a characteristic that has been exploited in the development of the 14 C-urea breath test (UBT). 14 C-UBT is being used as a highly reliable test for the diagnosis of H. pylori infection. There is paucity of reports on the utility of this test to confirm the H. pylori eradication after its treatment. The study was conducted to determine the utility of 14 C-UBT in confirming the eradication of H. pylori

  7. Direct Imaging Confirmation and Characterization of a Dust-Enshrouded Candidate Exoplanet Orbiting Fomalhaut

    OpenAIRE

    Currie, Thayne; Debes, John; Rodigas, Timothy J.; Burrows, Adam; Itoh, Yoichi; Fukagawa, Misato; Kenyon, Scott; Kuchner, Marc; Matsumura, Soko

    2012-01-01

    We present Subaru/IRCS J band data for Fomalhaut and a (re)reduction of archival 2004--2006 HST/ACS data first presented by Kalas et al. (2008). We confirm the existence of a candidate exoplanet, Fomalhaut b, in both the 2004 and 2006 F606W data sets at a high signal-to-noise. Additionally, we confirm the detection at F814W and present a new detection in F435W. Fomalhaut b's space motion may be consistent with it being in an apsidally-aligned, non debris ring-crossing orbit, although new astr...

  8. The Multiplicative Situation

    Science.gov (United States)

    Hurst, Chris

    2015-01-01

    The relationships between three critical elements, and the associated mathematical language, to assist students to make the critical transition from additive to multiplicative thinking are examined in this article by Chris Hurst.

  9. Connecting the Production Multiple

    DEFF Research Database (Denmark)

    Lichen, Alex Yu; Mouritsen, Jan

    was implementing sales and operations planning (S&OP) process to foster integration on its demand chain. Although actors wanted to see what it is to produce, that is to say, the object Production, as a singular object that could be diffused across time and space, Production became more multiple because the S......&OP process itself is a fluid object, but there is still possibility to organise the messy Production. There are connections between the Production multiple and the managerial technology fluid. The fluid enacted the multiplicity of Production thus making it more difficult to be organised because there were...... not judge success or failure of accounting on whether accounting does solve the problem in singular but whether accounting is fluid enough to connect separate multiples....

  10. Multiple Stages 2

    DEFF Research Database (Denmark)

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  11. Taking multiple medicines safely

    Science.gov (United States)

    ... medlineplus.gov/ency/patientinstructions/000883.htm Taking multiple medicines safely To use the sharing features on this ... directed. Why You May Need More Than One Medicine You may take more than one medicine to ...

  12. Very high multiplicity physics

    CERN Document Server

    Mandjavidze, I D

    2001-01-01

    The status of the programme of studying processes with high multiplicity, when inelasticity is close to unity, is considered. The definition of the processes under study is given, and the motivation of investigations and the experimentally observed predictions are discussed

  13. Rehabilitation and multiple sclerosis

    DEFF Research Database (Denmark)

    Dalgas, Ulrik

    2011-01-01

    of their lives, emphasising the importance of rehabilitation in order to maintain quality of life. An important aspect of multiple sclerosis rehabilitation is the preservation of physical functioning. Hot topics in the rehabilitation of physical function include (1) exercise therapy, (2) robot-assisted training......, a paradigm shift is taking place and it is now increasingly acknowledged that exercise therapy is both safe and beneficial. Robot-assisted training is also attracting attention in multiple sclerosis rehabilitation. Several sophisticated commercial robots exist, but so far the number of scientific studies......In a chronic and disabling disease like multiple sclerosis, rehabilitation becomes of major importance in the preservation of physical, psychological and social functioning. Approximately 80% of patients have multiple sclerosis for more than 35 years and most will develop disability at some point...

  14. Multiple indicators, multiple causes measurement error models.

    Science.gov (United States)

    Tekwe, Carmen D; Carter, Randy L; Cullings, Harry M; Carroll, Raymond J

    2014-11-10

    Multiple indicators, multiple causes (MIMIC) models are often employed by researchers studying the effects of an unobservable latent variable on a set of outcomes, when causes of the latent variable are observed. There are times, however, when the causes of the latent variable are not observed because measurements of the causal variable are contaminated by measurement error. The objectives of this paper are as follows: (i) to develop a novel model by extending the classical linear MIMIC model to allow both Berkson and classical measurement errors, defining the MIMIC measurement error (MIMIC ME) model; (ii) to develop likelihood-based estimation methods for the MIMIC ME model; and (iii) to apply the newly defined MIMIC ME model to atomic bomb survivor data to study the impact of dyslipidemia and radiation dose on the physical manifestations of dyslipidemia. As a by-product of our work, we also obtain a data-driven estimate of the variance of the classical measurement error associated with an estimate of the amount of radiation dose received by atomic bomb survivors at the time of their exposure. Copyright © 2014 John Wiley & Sons, Ltd.

  15. Smoldering Multiple Myeloma

    OpenAIRE

    Gao, Minjie; Yang, Guang; Kong, Yuanyuan; Wu, Xiaosong; Shi, Jumei

    2015-01-01

    Smoldering multiple myeloma (SMM) is an asymptomatic precursor stage of multiple myeloma (MM) characterized by clonal bone marrow plasma cells (BMPC) ≥ 10% and/or M protein level ≥ 30 g/L in the absence of end organ damage. It represents an intermediate stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic MM. The risk of progression to symptomatic MM is not uniform, and several parameters have been reported to predict the risk of progression. These include t...

  16. Smoldering multiple myeloma

    OpenAIRE

    Rajkumar, S. Vincent; Landgren, Ola; Mateos, María-Victoria

    2015-01-01

    Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder. SMM is distinguished from monoclonal gammopathy of undetermined significance by a much higher risk of progression to multiple myeloma (MM). There have been major advances in the diagnosis, prognosis, and management of SMM in the last few years. These include a revised disease definition, identification of several new prognostic factors, a classification based on underlying cytogenetic changes, and...

  17. Generalized internal multiple imaging

    KAUST Repository

    Zuberi, M. A. H.

    2014-08-05

    Internal multiples deteriorate the image when the imaging procedure assumes only single scattering, especially if the velocity model does not have sharp contrasts to reproduce such scattering in the Green’s function through forward modeling. If properly imaged, internal multiples (internally scattered energy) can enhance the seismic image. Conventionally, to image internal multiples, accurate, sharp contrasts in the velocity model are required to construct a Green’s function with all the scattered energy. As an alternative, we have developed a generalized internal multiple imaging procedure that images any order internal scattering using the background Green’s function (from the surface to each image point), constructed from a smooth velocity model, usually used for conventional imaging. For the first-order internal multiples, the approach consisted of three steps, in which we first back propagated the recorded surface seismic data using the background Green’s function, then crosscorrelated the back-propagated data with the recorded data, and finally crosscorrelated the result with the original background Green’s function. This procedure images the contribution of the recorded first-order internal multiples, and it is almost free of the single-scattering recorded energy. The cost includes one additional crosscorrelation over the conventional single-scattering imaging application. We generalized this method to image internal multiples of any order separately. The resulting images can be added to the conventional single-scattering image, obtained, e.g., from Kirchhoff or reverse-time migration, to enhance the image. Application to synthetic data with reflectors illuminated by multiple scattering (double scattering) demonstrated the effectiveness of the approach.

  18. Neutron source multiplication method

    International Nuclear Information System (INIS)

    Clayton, E.D.

    1985-01-01

    Extensive use has been made of neutron source multiplication in thousands of measurements of critical masses and configurations and in subcritical neutron-multiplication measurements in situ that provide data for criticality prevention and control in nuclear materials operations. There is continuing interest in developing reliable methods for monitoring the reactivity, or k/sub eff/, of plant operations, but the required measurements are difficult to carry out and interpret on the far subcritical configurations usually encountered. The relationship between neutron multiplication and reactivity is briefly discussed and data presented to illustrate problems associated with the absolute measurement of neutron multiplication and reactivity in subcritical systems. A number of curves of inverse multiplication have been selected from a variety of experiments showing variations observed in multiplication during the course of critical and subcritical experiments where different methods of reactivity addition were used, with different neutron source detector position locations. Concern is raised regarding the meaning and interpretation of k/sub eff/ as might be measured in a far subcritical system because of the modal effects and spectrum differences that exist between the subcritical and critical systems. Because of this, the calculation of k/sub eff/ identical with unity for the critical assembly, although necessary, may not be sufficient to assure safety margins in calculations pertaining to far subcritical systems. Further study is needed on the interpretation and meaning of k/sub eff/ in the far subcritical system

  19. Making Students Feel Better: Examining the Relationships between Teacher Confirmation and College Students' Emotional Outcomes

    Science.gov (United States)

    Goldman, Zachary W.; Goodboy, Alan K.

    2014-01-01

    Guided by broaden-and-build theory and emotional response theory, we examined college students' emotional outcomes in the classroom (i.e., emotional interest, emotional support, emotion work, emotional valence) as a function of teacher confirmation (i.e., responding to questions, demonstrating interest, teaching style). Participants were 159…

  20. Confirmation of sunflower F1 hybrids using SDS-PAGE analysis

    African Journals Online (AJOL)

    USER

    2010-06-14

    Jun 14, 2010 ... Among bio-chemical techniques, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-. PAGE) is most widely used due to its validity and simplicity for describing genetic structures of group of plants. In the present study, SDS-PAGE was used to confirm sunflower hybrids. Four male sterile.

  1. Conclusiveness of fine needle aspiration in 2419 histologically confirmed benign and malignant breast lesions

    NARCIS (Netherlands)

    Kooistra, B.; Wauters, C.; Wobbes, T.; Strobbe, L.

    2011-01-01

    We aimed to retrospectively assess (1) the conclusiveness of breast fine needle aspiration (FNA) in a histologically confirmed population and (2) the clinical and radiologic determinants of a conclusive diagnosis. Aspirates were diagnosed as inadequate, benign, atypical, suspicious or malignant. We

  2. Counselor Confirmation of Middle School Student Self-Reports of Bullying Victimization

    Science.gov (United States)

    Cornell, Dewey; Mehta, Sharmila B.

    2011-01-01

    School counselors frequently use self-report surveys to assess bullying despite little research on their accuracy. In this study, counselor follow-up interviews found that only 24 (56%) of 43 middle school students who self-identified as victims of bullying could be confirmed as actual victims. Other students described peer conflicts that did not…

  3. Stereotype confirmation concerns predict dropout from cognitive behavioral therapy for social anxiety disorder.

    Science.gov (United States)

    Johnson, Suzanne; Price, Matthew; Mehta, Natasha; Anderson, Page L

    2014-08-19

    There are high attrition rates observed in efficacy studies for social anxiety disorder, and research has not identified consistent nor theoretically meaningful predictors of dropout. Pre-treatment symptom severity and demographic factors, such as age and gender, are sometimes predictive of dropout. The current study examines a theoretically meaningful predictor of attrition based on experiences associated with social group membership rather than differences between social group categories--fear of confirming stereotypes. This is a secondary data analysis of a randomized controlled trial comparing two cognitive behavioral treatments for social anxiety disorder: virtual reality exposure therapy and exposure group therapy. Participants (N = 74) with a primary diagnosis of social anxiety disorder who were eligible to participate in the parent study and who self-identified as either "African American" (n = 31) or "Caucasian" (n = 43) completed standardized self-report measures of stereotype confirmation concerns (SCC) and social anxiety symptoms as part of a pre-treatment assessment battery. Hierarchical logistic regression showed that greater stereotype confirmation concerns were associated with higher dropout from therapy--race, age, gender, and pre-treatment symptom severity were not. Group treatment also was associated with higher dropout. These findings urge further research on theoretically meaningful predictors of attrition and highlight the importance of addressing cultural variables, such as the experience of stereotype confirmation concerns, during treatment of social anxiety to minimize dropout from therapy.

  4. Atypical myopathy in Denmark confirmed with the aTRAQ assay

    DEFF Research Database (Denmark)

    Høffer, Sofie Esbjørn; Votion, Dominique-Marie; Anderberg, Marie

    2016-01-01

    Atypical myopathy is a severe form of rhabdomyolysis that occurs in grazing horses. Over the past decades, the disease has been emerging in Europe. The disease is widespread in Europe and has been suspected in Denmark since 2000, yet no cases have been confirmed. The objective of this study was t...

  5. Aberrant right subclavian artery aneurysm confirmed by computerized tomography. Aneurisma de arteria subclavia derecha aberrante

    Energy Technology Data Exchange (ETDEWEB)

    Arteche, M.D.; Tejera, E.; Vega-Hazas, G.

    1991-01-01

    We present a case of aberrant right subclavian artery aneurysm in an asymptomatic woman. This disorder was found by chance in a thorax radiography due to an upper right mediastinal mass. CT confirmed the vascular anomaly as well as the aneurysm occurrence. (Author)

  6. Iodamoeba butschlii in an anal pap test confirmed by iodine stain.

    Science.gov (United States)

    Schuetz, Audrey N; Pritt, Bobbi S; Schreiner, Andrew M

    2014-09-01

    We report the finding of Iodamoeba butschlii amebic cysts on a liquid-based anal Pap smear from an HIV-positive male. Iodine staining of the smear confirmed the diagnosis. It is important to distinguish I. butschlii from pathogenic ameobae and other organisms seen on anal Pap smears. Copyright © 2013 Wiley Periodicals, Inc.

  7. Video Game Effects--Confirmed, Suspected, and Speculative: A Review of the Evidence

    Science.gov (United States)

    Barlett, Christopher P.; Anderson, Craig A.; Swing, Edward L.

    2009-01-01

    This literature review focuses on the confirmed, suspected, and speculative effects of violent and non-violent video game exposure on negative and positive outcomes. Negative outcomes include aggressive feelings, aggressive thoughts, aggressive behavior, physiological arousal, and desensitization, whereas positive outcomes include various types of…

  8. 78 FR 68713 - Listing of Color Additives Exempt From Certification; Spirulina Extract; Confirmation of...

    Science.gov (United States)

    2013-11-15

    .... FDA-2011-C-0878] Listing of Color Additives Exempt From Certification; Spirulina Extract; Confirmation... rule amended the color additive regulations to provide for the safe use of spirulina extract made from the dried biomass of the cyanobacteria Arthrospira platensis (A. platensis), as a color additive in...

  9. 76 FR 59503 - Listing of Color Additives Exempt From Certification; Reactive Blue 69; Confirmation of Effective...

    Science.gov (United States)

    2011-09-27

    .... FDA-2009-C-0543] Listing of Color Additives Exempt From Certification; Reactive Blue 69; Confirmation... rule amended the color additive regulations to provide for the safe use of disodium 1-amino-4-[[4-[(2... Reg. No. 70209-99- 3), also known as Reactive Blue 69, as a color additive in contact lenses. DATES...

  10. An improved 10-SSR pyrus fingerprinting DNA test to confirm parentage [abstract

    Science.gov (United States)

    Pedigree confirmation is a critical part of breeding, managing genetic resources, and developing genetic mapping populations for out-crossing plants, such as the genus Pyrus. Individuals which are not progeny of a biparental cross can cause mapping errors or result in the costly genotyping of indivi...

  11. 76 FR 12563 - Amendments to General Regulations of the Food and Drug Administration; Confirmation of Effective...

    Science.gov (United States)

    2011-03-08

    ... certain general regulations of FDA to include tobacco products, where appropriate, in light of FDA's... revising the Agency's regulations to require tobacco products to be subject to the same general... General Regulations of the Food and Drug Administration; Confirmation of Effective Date AGENCY: Food and...

  12. Repeated seasonal influenza vaccination among elderly in Europe: Effects on laboratory confirmed hospitalised influenza.

    NARCIS (Netherlands)

    Rondy, Marc; Launay, Odile; Castilla, Jesus; Costanzo, Simona; Puig-Barberà, Joan; Gefenaite, Giedre; Larrauri, Amparo; Rizzo, Caterina; Pitigoi, Daniela; Syrjänen, Ritva K; Machado, Ausenda; Kurečić Filipović, Sanja; Krisztina Horváth, Judit; Paradowska-Stankiewicz, Iwona; Marbus, Sierk; Moren, Alain

    2017-01-01

    In Europe, annual influenza vaccination is recommended to elderly. From 2011 to 2014 and in 2015-16, we conducted a multicentre test negative case control study in hospitals of 11 European countries to measure influenza vaccine effectiveness (IVE) against laboratory confirmed hospitalised influenza

  13. Verifying Parentage and Confirming Identity in Blackberry with a Fingerprinting Set

    Science.gov (United States)

    Parentage and identity confirmation is an important aspect of clonally propagated crops outcrossing. Potential errors resulting misidentification include off-type pollination events, labeling errors, or sports of clones. DNA fingerprinting sets are an excellent solution to quickly identify off-type ...

  14. Confirmation of molecular formulas of metallic complexes through X-ray fluorescence quantitative analysis

    International Nuclear Information System (INIS)

    Filgueiras, C.A.L.; Marques, E.V.; Machado, R.M.

    1984-01-01

    X-ray fluorescence spectrophotometry was employed to determined the metal content in a series of five transition element complexes (Mn, Ti, Zn, V). The results confirmed the molecular formulas of these complexes, already proposed on the basis of elemental microanalysis, solution condutimetry and other analytical methods. (C.L.B.) [pt

  15. Confirmation biases in selective exposure to political online information : Source bias vs. content bias

    NARCIS (Netherlands)

    Westerwick, Axel; Johnson, Benjamin K.; Knobloch-Westerwick, Silvia

    2017-01-01

    The present work examines the role of source vs. content cues for the confirmation bias, in which recipients spend more time with content aligning with preexisting attitudes. In addition to testing how both source and content cues facilitate this biased pattern of selective exposure, the study

  16. Laboratory dose confirmation of copper sulfate for treating fungus on channel catfish eggs

    Science.gov (United States)

    Two dose confirmation studies are required by the U.S. Food and Drug Administration to verify the effectiveness of a potential candidate to gain approval as a new animal drug; the studies provide independent substantiation of the results. This laboratory study was designed to compare an untreated c...

  17. The price of information: Increased inspection costs reduce the confirmation bias in visual search.

    Science.gov (United States)

    Rajsic, Jason; Wilson, Daryl E; Pratt, Jay

    2018-04-01

    In visual search, there is a confirmation bias such that attention is biased towards stimuli that match a target template, which has been attributed to covert costs of updating the templates that guide search [Rajsic, Wilson, & Pratt, 2015. Confirmation bias in visual search. Journal of Experimental Psychology: Human Perception and Performance. Advance online publication. doi:10.1037/xhp0000090]. In order to provide direct evidence for this speculation, the present study increased the cost of inspections in search by using gaze- and mouse-contingent searches, which restrict the manner in which information in search displays can be accrued, and incur additional motor costs (in the case of mouse-contingent searches). In a fourth experiment, we rhythmically mask elements in the search display to induce temporal inspection costs. Our results indicated that confirmation bias is indeed attenuated when inspection costs are increased. We conclude that confirmation bias results from the low-cost strategy of matching information to a single, concrete visual template, and that more sophisticated guidance strategies will be used when sufficiently beneficial. This demonstrates that search guidance itself comes at a cost, and that the form of guidance adopted in a given search depends on a comparison between guidance costs and the expected benefits of their implementation.

  18. Swift/BAT confirms the giant outburst of H 1417-624

    Science.gov (United States)

    Krimm, H. A.; Barthelmy, S. D.; Cummings, J. R.; Lien, A. Y.; Markwardt, C. B.; Palmer, D. M.; Sakamoto, T.; Stamatikos, M.; Ukwatta, T. N.

    2018-04-01

    The Swift/BAT transient monitor confirms the current outburst from the Be/X-ray binary pulsar, H 1417-624 ( = 2S 1417-624) (Nakajima et al., ATel #11479). In the BAT 15-50 keV energy band, the outburst began approximately on 20 March 2018 (MJD 57467) and the count rate has been steadily rising since that time.

  19. 78 FR 76721 - Removal of Transferred OTS Regulations Regarding Recordkeeping and Confirmation Requirements for...

    Science.gov (United States)

    2013-12-19

    ... connection with the implementation of applicable provisions of Title III of the Dodd-Frank Wall Street Reform...\\ Dodd-Frank Wall Street Reform and Consumer Protection Act, Public Law 111-203, 124 Stat. 1376 (2010... Confirmation Requirements for Securities Transactions.'' The rescinded regulation was one of several rules...

  20. A simple technique for on-table confirmation of locking screw ...

    African Journals Online (AJOL)

    Background: Locked intramedullary nailing is the standard of care for femoral and tibial shaft fractures. Correct placement of locking screws is often an ordeal followed at times by a tormenting wait for check radiographs to confirm whether or not the locking screws were correctly placed. Objective: We present a simple, ...

  1. a simple technique for on-table confirmation of locking screw ...

    African Journals Online (AJOL)

    2012-09-06

    Sep 6, 2012 ... Background: Locked intramedullary nailing is the standard of care for femoral and tibial shaft fractures. Correct placement of locking screws is often an ordeal followed at times by a tormenting wait for check radiographs to confirm whether or not the locking screws were correctly placed. Objective:We ...

  2. 77 FR 33808 - Agency Information Collection; Activity Under OMB Review: Report of Passengers Denied Confirmed...

    Science.gov (United States)

    2012-06-07

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation Statistics (BTS), DOT. ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act of..., Office of Airline Information, RTS-42, Room E34-410, RITA, BTS, 1200 New Jersey Avenue SE., Washington...

  3. 78 FR 60997 - Agency Information Collection: Activity Under OMB Review: Report of Passengers Denied Confirmed...

    Science.gov (United States)

    2013-10-02

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation Statistics (BTS), DOT. ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act of...: Cecelia Robinson, Office of Airline Information, RTS-42, Room E34-410, RITA, BTS, 1200 New Jersey Avenue...

  4. 75 FR 21717 - Agency Information Collection; Activity Under OMB Review; Report of Passengers Denied Confirmed...

    Science.gov (United States)

    2010-04-26

    ... Confirmed Space--BTS Form 251 AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation Statistics (BTS), DOT. ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction Act of... and other governmental parties to comment on the continuing need for and usefulness of BTS collecting...

  5. Confirmation of cross-fertilization using molecular markers in ornamental passion flower hybrids.

    Science.gov (United States)

    Conceição, L D H C S; Belo, G O; Souza, M M; Santos, S F; Cerqueira-Silva, C B M; Corrêa, R X

    2011-01-11

    Several interspecific Passiflora hybrids are produced in the northern hemisphere for the ornamental plant market. In Brazil, production of passion flower hybrids is limited to the introgression of genes into the main cultivated species, yellow passion fruit, to be used as rootstocks. Confirmation of hybridization in the initial developmental stage is important for breeding perennial and sub-perennial plants, such as passion flowers, reducing time and costs in plant stock maintenance. In order to obtain F₁ hybrids with ornamental potential, four species of Passiflora (P. alata, P. gardneri, P. gibertii, and P. watsoniana) from the Active Germplasm Bank at UESC were hybridized. Flower buds, in pre-anthesis, of the genitors were previously protected, and the female buds were emasculated. To confirm hybridization, the genomic DNA of the genitor species and the supposed hybrids was extracted and RAPD primers were used to obtain molecular markers and select passion flower interspecific hybrids. Eight primers were used to confirm hybrids derived from P. gardneri with P. alata, P. watsoniana with P. alata, P. watsoniana with P. gardneri, and P. gardneri with P. gibertii; 75, 50, 45, and 46% of the informative bands, respectively, confirmed the hybrid nature of these plants. The RAPD technique was effective in the early identification of hybrids; this will be useful for development of hybrid Passiflora progeny.

  6. 42 CFR 422.2272 - Licensing of marketing representatives and confirmation of marketing resources.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Licensing of marketing representatives and confirmation of marketing resources. 422.2272 Section 422.2272 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements ...

  7. 42 CFR 423.2272 - Licensing of marketing representatives and confirmation of marketing resources.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Licensing of marketing representatives and confirmation of marketing resources. 423.2272 Section 423.2272 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Part D Marketing...

  8. Confirmational Response Bias and the Quality of the Editorial Processes among American Social Work Journals

    Science.gov (United States)

    Epstein, William M.

    2004-01-01

    Objective: To experimentally test for confirmational response bias among social work journals and to assess the time-liness and quality of the referee review process. Method: A positive and a negative version of two stimulus articles were sent to two randomized groups of 31 social work journals; journals were stratified by prestige; the timeliness…

  9. Creep measurements confirm steady flow after stress maximum in extension of branched polymer melts

    DEFF Research Database (Denmark)

    Javier Alvarez, Nicolas; Román Marín, José Manuel; Huang, Qian

    2013-01-01

    the possibility of the overshoot being an experimental artifact by confirming the existence of steady flow after a maximum in the ratio of stress to strain rate versus strain under both constant stress and constant strain-rate kinematics. This observation indicates the omission of important physics from current...

  10. DIRECT IMAGING CONFIRMATION AND CHARACTERIZATION OF A DUST-ENSHROUDED CANDIDATE EXOPLANET ORBITING FOMALHAUT

    Energy Technology Data Exchange (ETDEWEB)

    Currie, Thayne [Department of Astronomy and Astrophysics, University of Toronto, Toronto, ON (Canada); Debes, John [Space Telescope Science Institute, Baltimore, MD (United States); Rodigas, Timothy J. [Steward Observatory, University of Arizona, Tucson, AZ (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, Princeton, NJ (United States); Itoh, Yoichi [Nishi-Harima Observatory, University of Hyogo, Kobe (Japan); Fukagawa, Misato [Department of Earth and Space Sciences, Osaka University, Osaka (Japan); Kenyon, Scott J. [Smithsonian Astrophysical Observatory, Cambridge, MA (United States); Kuchner, Marc [Stellar and Exoplanets Laboratory, NASA-Goddard Space Flight Center, Greenbelt, MD (United States); Matsumura, Soko, E-mail: currie@astro.utoronto.ca [Department of Astronomy, University of Maryland-College Park, College Park, MD (United States)

    2012-12-01

    We present Subaru/IRCS J-band data for Fomalhaut and a (re)reduction of archival 2004-2006 HST/ACS data first presented by Kalas et al. We confirm the existence of a candidate exoplanet, Fomalhaut b, in both the 2004 and 2006 F606W data sets at a high signal-to-noise ratio. Additionally, we confirm the detection at F814W and present a new detection in F435W. Fomalhaut b's space motion may be consistent with it being in an apsidally aligned, non-debris ring-crossing orbit, although new astrometry is required for firmer conclusions. We cannot confirm that Fomalhaut b exhibits 0.7-0.8 mag variability cited as evidence for planet accretion or a semi-transient dust cloud. The new, combined optical spectral energy distribution and IR upper limits confirm that emission identifying Fomalhaut b originates from starlight scattered by small dust, but this dust is most likely associated with a massive body. The Subaru and IRAC/4.5 {mu}m upper limits imply M < 2 M{sub J} , still consistent with the range of Fomalhaut b masses needed to sculpt the disk. Fomalhaut b is very plausibly 'a planet identified from direct imaging' even if current images of it do not, strictly speaking, show thermal emission from a directly imaged planet.

  11. DIRECT IMAGING CONFIRMATION AND CHARACTERIZATION OF A DUST-ENSHROUDED CANDIDATE EXOPLANET ORBITING FOMALHAUT

    International Nuclear Information System (INIS)

    Currie, Thayne; Debes, John; Rodigas, Timothy J.; Burrows, Adam; Itoh, Yoichi; Fukagawa, Misato; Kenyon, Scott J.; Kuchner, Marc; Matsumura, Soko

    2012-01-01

    We present Subaru/IRCS J-band data for Fomalhaut and a (re)reduction of archival 2004-2006 HST/ACS data first presented by Kalas et al. We confirm the existence of a candidate exoplanet, Fomalhaut b, in both the 2004 and 2006 F606W data sets at a high signal-to-noise ratio. Additionally, we confirm the detection at F814W and present a new detection in F435W. Fomalhaut b's space motion may be consistent with it being in an apsidally aligned, non-debris ring-crossing orbit, although new astrometry is required for firmer conclusions. We cannot confirm that Fomalhaut b exhibits 0.7-0.8 mag variability cited as evidence for planet accretion or a semi-transient dust cloud. The new, combined optical spectral energy distribution and IR upper limits confirm that emission identifying Fomalhaut b originates from starlight scattered by small dust, but this dust is most likely associated with a massive body. The Subaru and IRAC/4.5 μm upper limits imply M J , still consistent with the range of Fomalhaut b masses needed to sculpt the disk. Fomalhaut b is very plausibly 'a planet identified from direct imaging' even if current images of it do not, strictly speaking, show thermal emission from a directly imaged planet.

  12. 78 FR 66841 - Turtles Intrastate and Interstate Requirements; Confirmation of Effective Date

    Science.gov (United States)

    2013-11-07

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 1240 [Docket No. FDA-2013-N-0639] Turtles Intrastate and Interstate Requirements; Confirmation of Effective Date AGENCY... turtle eggs and live turtles with a carapace length of less than 4 inches to remove procedures for...

  13. 75 FR 34360 - Listing of Color Additives Exempt From Certification; Bismuth Citrate; Confirmation of Effective...

    Science.gov (United States)

    2010-06-17

    .... FDA-2008-C-0098] Listing of Color Additives Exempt From Certification; Bismuth Citrate; Confirmation... final rule amended the color additive regulations by increasing the permitted use level of bismuth... permitted use level of bismuth citrate as a color additive in cosmetics intended for coloring hair on the...

  14. Incidental Risk of Type 2 Diabetes Mellitus among Patients with Confirmed and Unconfirmed Prediabetes.

    Directory of Open Access Journals (Sweden)

    Kimberly D Brunisholz

    Full Text Available To determine the risk of type 2 diabetes (T2DM diagnosis among patients with confirmed and unconfirmed prediabetes (preDM relative to an at-risk group receiving care from primary care physicians over a 5-year period.Utilizing data from the Intermountain Healthcare (IH Enterprise Data Warehouse (EDW from 2006-2013, we performed a prospective analysis using discrete survival analysis to estimate the time to diagnosis of T2DM among groups.Adult patients who had at least one outpatient visit with a primary care physician during 2006-2008 at an IH clinic and subsequent visits through 2013. Patients were included for the study if they were (a at-risk for diabetes (BMI ≥ 25 kg/m2 and one additional risk factor: high risk ethnicity, first degree relative with diabetes, elevated triglycerides or blood pressure, low HDL, diagnosis of gestational diabetes or polycystic ovarian syndrome, or birth of a baby weighing >9 lbs; or (b confirmed preDM (HbA1c ≥ 5.7-6.49% or fasting blood glucose 100-125 mg/dL; or (c unconfirmed preDM (documented fasting lipid panel and glucose 100-125 mg/dL on the same day.Of the 33,838 patients who were eligible for study, 57.0% were considered at-risk, 38.4% had unconfirmed preDM, and 4.6% had confirmed preDM. Those with unconfirmed and confirmed preDM tended to be Caucasian and a greater proportion were obese compared to those at-risk for disease. Patients with unconfirmed and confirmed preDM tended to have more prevalent high blood pressure and depression as compared to the at-risk group. Based on the discrete survival analyses, patients with unconfirmed preDM and confirmed preDM were more likely to develop T2DM when compared to at-risk patients.Unconfirmed and confirmed preDM are strongly associated with the development of T2DM as compared to patients with only risk factors for disease.

  15. MULTIPLE SPINAL CANAL MENINGIOMAS

    Directory of Open Access Journals (Sweden)

    Nandigama Pratap Kumar

    2016-10-01

    Full Text Available BACKGROUND Meningiomas of the spinal canal are common tumours with the incidence of 25 percent of all spinal cord tumours. But multiple spinal canal meningiomas are rare in compare to solitary lesions and account for 2 to 3.5% of all spinal meningiomas. Most of the reported cases are both intra cranial and spinal. Exclusive involvement of the spinal canal by multiple meningiomas are very rare. We could find only sixteen cases in the literature to the best of our knowledge. Exclusive multiple spinal canal meningiomas occurring in the first two decades of life are seldom reported in the literature. We are presenting a case of multiple spinal canal meningiomas in a young patient of 17 years, who was earlier operated for single lesion. We analysed the literature, with illustration of our case. MATERIALS AND METHODS In September 2016, we performed a literature search for multiple spinal canal meningiomas involving exclusively the spinal canal with no limitation for language and publication date. The search was conducted through http://pubmed.com, a wellknown worldwide internet medical address. To the best of our knowledge, we could find only sixteen cases of multiple meningiomas exclusively confined to the spinal canal. Exclusive multiple spinal canal meningiomas occurring in the first two decades of life are seldom reported in the literature. We are presenting a case of multiple spinal canal meningiomas in a young patient of 17 years, who was earlier operated for solitary intradural extra medullary spinal canal meningioma at D4-D6 level, again presented with spastic quadriparesis of two years duration and MRI whole spine demonstrated multiple intradural extra medullary lesions, which were excised completely and the histopathological diagnosis was transitional meningioma. RESULTS Patient recovered from his weakness and sensory symptoms gradually and bladder and bowel symptoms improved gradually over a period of two to three weeks. CONCLUSION Multiple

  16. Lung ultrasound as a diagnostic tool for radiographically-confirmed pneumonia in low resource settings.

    Science.gov (United States)

    Ellington, Laura E; Gilman, Robert H; Chavez, Miguel A; Pervaiz, Farhan; Marin-Concha, Julio; Compen-Chang, Patricia; Riedel, Stefan; Rodriguez, Shalim J; Gaydos, Charlotte; Hardick, Justin; Tielsch, James M; Steinhoff, Mark; Benson, Jane; May, Evelyn A; Figueroa-Quintanilla, Dante; Checkley, William

    2017-07-01

    Pneumonia is a leading cause of morbidity and mortality in children worldwide; however, its diagnosis can be challenging, especially in settings where skilled clinicians or standard imaging are unavailable. We sought to determine the diagnostic accuracy of lung ultrasound when compared to radiographically-confirmed clinical pediatric pneumonia. Between January 2012 and September 2013, we consecutively enrolled children aged 2-59 months with primary respiratory complaints at the outpatient clinics, emergency department, and inpatient wards of the Instituto Nacional de Salud del Niño in Lima, Peru. All participants underwent clinical evaluation by a pediatrician and lung ultrasonography by one of three general practitioners. We also consecutively enrolled children without respiratory symptoms. Children with respiratory symptoms had a chest radiograph. We obtained ancillary laboratory testing in a subset. Final clinical diagnoses included 453 children with pneumonia, 133 with asthma, 103 with bronchiolitis, and 143 with upper respiratory infections. In total, CXR confirmed the diagnosis in 191 (42%) of 453 children with clinical pneumonia. A consolidation on lung ultrasound, which is our primary endpoint for pneumonia, had a sensitivity of 88.5%, specificity of 100%, and an area under-the-curve of 0.94 (95% CI 0.92-0.97) when compared to radiographically-confirmed clinical pneumonia. When any abnormality on lung ultrasound was compared to radiographically-confirmed clinical pneumonia the sensitivity increased to 92.2% and the specificity decreased to 95.2%, with an area under-the-curve of 0.94 (95% CI 0.91-0.96). Lung ultrasound had high diagnostic accuracy for the diagnosis of radiographically-confirmed pneumonia. Added benefits of lung ultrasound include rapid testing and high inter-rater agreement. Lung ultrasound may serve as an alternative tool for the diagnosis of pediatric pneumonia. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights

  17. Core top confirmation of the carbonate ion effect in multiple species of planktic foraminifera and a reassessment of the upper water column equatorial Pacific δ13CFORAM records.

    Science.gov (United States)

    Fehrenbacher, J. S.; Spero, H. J.

    2017-12-01

    Planktic foraminifera carbon (δ13CFORAM) and oxygen (δ18OFORAM) isotope records play a vital role in paleoceanographic reconstructions. The δ18OFORAM values are typically minimally offset from equilibrium δ18O-calcite and are widely applied in oceanographic reconstructions of upper water column hydrography. In contrast, δ13CFORAM are underutilized in paleoceanographic reconstructions. δ13CFORAM are more difficult to interpret due to species-specific δ13CFORAM offsets from the δ13C of the dissolved inorganic carbon of seawater (δ13CDIC). In this study, we analyzed the δ18OFORAM and δ13CFORAM of individual foraminifera shells from a suite of planktic foraminifer species obtained from core top (Holocene) intervals from Eastern Equatorial Pacific (TR163-19), Western Caribbean (ODP 999A), and Equatorial Indian Ocean (ODP 714A) cores. We also include published records from the Western Equatorial Pacific (MW91-9 15GGC). We find the δ13CFORAM offsets from the local water column δ13CDIC are large, variable, region specific, and are correlated to the ambient carbonate ion concentration ([CO32-]) of seawater. We show that the regional offsets from δ13CDIC are due to the carbonate ion effect (CIE) on δ13CFORAM (Spero et al., 1997; Bijma et al., 1999) and variations in water column [CO32-]. More importantly, our results demonstrate that regional and/or culture based δ13CFORAM offsets from δ13CDIC are not applicable globally. Rather, owing to regional differences in water column [CO32-] and species-specific relationships between [CO32-] and δ13CFORAM, δ13CFORAM must be corrected for the regional CIE in order to infer vertical δ13CDIC gradients or to compare δ13CFORAM records from one region to another. Laboratory culture suggests the carbonate ion effect on δ18OFORAM is 1/3 that of δ13CFORAM (Spero et al., 1997). Thus, in order to obtain correct δ18OFORAM temperatures or δ18OSW (when used in conjunction with Mg/Ca) the δ18OFORAM offsets from δ18OCALCITE-EQ must also be corrected for offsets due to the carbonate ion effect. Finally, we use the regional d13CFORAM offsets from d13CDIC to correct for the CIE and reassess the δ13CFORAM and δ18OFORAM gradients from previously published down core records in the EEP (TR163-19; Spero et al., 2003).

  18. The many faces of solitary and multiple erythema migrans.

    Science.gov (United States)

    Eriksson, Pernilla; Schröder, Marika T; Niiranen, Kirsi; Nevanlinna, Antti; Panelius, Jaana; Ranki, Annamari

    2013-11-01

    Case definitions for European Lyme disease have been published. However, multiple erythema migrans may pose a diagnostic challenge. Therefore, we retrospectively reviewed the clinical and serological findings and response to therapy in a cohort of consecutive 54 patients with PCR-confirmed erythema migrans, referred to a university dermatology clinic. The proportion of patients with multiple erythema migrans lesions (usually 2 or 3) was almost equal (46%) to the proportion of patients with single erythema migrans lesions (54%). All patients, except for 2 multiple erythema migrans patients with a concomitant autoimmune disease, completely responded to treatment. In conclusion, multiple erythema migrans may be more common than anticipated, and since only 50% of the patients were seropositive when seeking medi-cal help, PCR testing of skin lesions is helpful to confirm the diagnosis in clinically atypical cases.

  19. Lay Evaluation of Financial Experts: The Action Advice Effect and Confirmation Bias.

    Science.gov (United States)

    Zaleskiewicz, Tomasz; Gasiorowska, Agata; Stasiuk, Katarzyna; Maksymiuk, Renata; Bar-Tal, Yoram

    2016-01-01

    The goal of this experimental project was to investigate lay peoples' perceptions of epistemic authority (EA) in the field of finance. EA is defined as the extent to which a source of information is treated as evidence for judgments independently of its objective expertise and based on subjective beliefs. Previous research suggested that EA evaluations are biased and that lay people tend to ascribe higher EA to experts who advise action (in the case of medical experts) or confirm clients' expectations (in the case of politicians). However, there has been no research into biases in lay evaluations of financial experts and this project is aimed to fill this gap. Experiment 1 showed that lay people tended to ascribe greater authority to financial consultants who gave more active advice to clients considering taking out a mortgage. Experiment 2 confirmed the action advice effect found in Experiment 1. However, the outcomes of Experiments 2 and - particularly - 3 suggested that this bias might also be due to clients' desire to confirm their own opinions. Experiment 2 showed that the action advice effect was moderated by clients' own opinions on taking loans. Lay people ascribed the greatest EA to the advisor in the scenario in which he advised taking action and where this coincided with the client's positive opinion on the advisability of taking out a loan. In Experiment 3 only participants with a positive opinion on the financial product ascribed greater authority to experts who recommended it; participants whose opinion was negative tended to rate consultants who advised rejecting the product more highly. To conclude, these three experiments revealed that lay people ascribe higher EA to financial consultants who advise action rather than maintenance of the status quo , but this effect is limited by confirmation bias: when the client's a priori opinion is salient, greater authority is ascribed to experts whose advice confirms it. In this sense, results presented in the

  20. Lay Evaluation of Financial Experts: The Action Advice Effect and Confirmation Bias

    Directory of Open Access Journals (Sweden)

    Tomasz Zaleskiewicz

    2016-09-01

    Full Text Available The goal of this experimental project was to investigate lay peoples’ perceptions of epistemic authority (EA in the field of finance. EA is defined as the extent to which a source of information is treated as evidence for judgments independently of its objective expertise and based on subjective beliefs. Previous research suggested that EA evaluations are biased and that lay people tend to ascribe higher EA to experts who advise action (in the case of medical experts or confirm clients’ expectations (in the case of politicians. However, there has been no research into biases in lay evaluations of financial experts and this project is aimed to fill this gap. Experiment 1 showed that lay people tended to ascribe greater authority to financial consultants who gave more active advice to clients considering taking out a mortgage. Experiment 2 confirmed the action advice effect found in Experiment 1. However, the outcomes of Experiments 2 and – particularly – 3 suggested that this bias might also be due to clients’ desire to confirm their own opinions. Experiment 2 showed that the action advice effect was moderated by clients’ own opinions on taking loans. Lay people ascribed the greatest EA to the advisor in the scenario in which he advised taking action and where this coincided with the client’s positive opinion on the advisability of taking out a loan. In Experiment 3 only participants with a positive opinion on the financial product ascribed greater authority to experts who recommended it; participants whose opinion was negative tended to rate consultants who advised rejecting the product more highly. To conclude, these three experiments revealed that lay people ascribe higher EA to financial consultants who advise action rather than maintenance of the status quo, but this effect is limited by confirmation bias: when the client’s a priori opinion is salient, greater authority is ascribed to experts whose advice confirms it. In this

  1. Limb apraxia in multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Rapaić Dragan

    2014-01-01

    Full Text Available Background/Aim. There are almost no studies on apraxia in people with multiple sclerosis. Although the white matter is damaged in MS, it is not the only location in which the pathological changes are present. Demyelinated lesions in the cortex have recently been recognized as important components of multiple sclerosis pathology. The aim of this study was to determine whether apraxia is present among people with MS, and the importance of demographic characteristics and impairment of functional systems at conceptualization and execution of movements. Methods. The experimental group consisted of 30 patients, mean age 51.34 ± 7.70 years. The patients in the experimental group were diagnosed with MS according to the McDonald criteria. The control group consisted of 30 healthy subjects, mean age 50.30 ± 10.47 years. For research purposes, we used the following instruments: Questionnaire for Collecting Demographic Data, Kurtzke Functional Systems Scores, Waterloo-Sunnybrook Apraxia Battery (WatAB. Execution of motion tasks that are a part of the Watwere incorporated in the System for the Observation and Analysis of Motor Behavior. Results. Our study showed that limb apraxia was common in people with MS. Apraxia was present during pantomime in 26.70% of the patients, and during the imitation of movements in 44.80% of the patients. Gender, age, education level, duration of disease and a form of MS did not determine the quality of conceptualization and execution of movements. The time elapsed from the last exacerbation was a determinant of quality of executed movements. Impairments of functional systems predicted impairments of movement execution. The expanded disability scale score correlated with the severity of apraxia. Conclusion. Our study confirm the presence of apraxia in MS. It is necessary to carry out further studies using functional magnetic resonance imaging, as well as the conduct longitudinal studies to determine the precise structure of

  2. Urinary tract infections in multiple sclerosis.

    Science.gov (United States)

    Phé, Véronique; Pakzad, Mahreen; Curtis, Carmel; Porter, Bernadette; Haslam, Collette; Chataway, Jeremy; Panicker, Jalesh N

    2016-06-01

    Urinary tract infections (UTIs) are commonly reported by people with multiple sclerosis (PwMS) and significantly impact quality of life. To provide an overview of the problem of UTIs in PwMS and offer a practical approach for the diagnosis and management. A review of the literature through a Pubmed search up to October 2015 was performed using the following keywords: multiple sclerosis, neurogenic bladder, urinary tract infections, relapse, dipsticks, culture, recurrent and prevention. Noteworthy topics include the definition of a confirmed symptomatic UTI as a positive urine culture defined by >10(5) colony-forming units (CFU)/mL or >10(4) CFU/mL if a urethral catheter urine sample is taken, or any count of bacteria in a suprapubic bladder puncture specimen, both in addition to symptoms including fever, pain, changes in lower urinary tract symptoms or neurological status. Urinalysis is useful to exclude a UTI; however, on its own is insufficient to confirm a UTI, for which urine culture is required. Experts advise asymptomatic UTIs should not be treated except in the context of an acute relapse. From international guidelines, there is no validated strategy to prevent recurrent UTIs in PwMS. This review provides an overview of the diagnosis, treatment and prevention of UTIs in the setting of multiple sclerosis (MS). © The Author(s), 2016.

  3. Fatigue in Multiple Sclerosis: (An update

    Directory of Open Access Journals (Sweden)

    Hossein Zarei

    2007-10-01

    Full Text Available BACKGROUND:To study the dimensions of fatigue in multiple sclerosis, its pathophysiology, the efficacy, tolerability and safety of drug and non-drug treatments and measurement of fatigue. METHODS: Relevant articles from PubMed and Google scholar search engines from January 1987 until September 2006 were studied to compose a short clinical update (not a systematic review and make the required clinical information available for the clinicians. RESULTS: There is evidence that fatigue is very common in all types and stages of multiple sclerosis, but its pathophysiology is not well explained. Consequently, few drug options have been offered for its treatment. Amantadine is the bestknown drug, though its efficacy and duration of action are limited. Pemoline and modafinil are alternatives and have
    some effects on fatigue. DAP (diaminopyridine, ASA (acetylsalicylic acid, methylphenidate and fluoxetine are other possible options but await further confirmation. Neurorehabilitation, regular exercise and cooling are confirmed to be of value in MS treatment. Measurement of fatigue is a complicated issue. At present fatigue does not have a laboratory marker. CONCLUSIONS: The results of this short clinical update provide guidelines for diagnosing MS-related fatigue and differentiating
    it from other similar physical and psychological conditions. It also examines prescription drug options and other therapies for MS patients with fatigue.
    KEYWORDS: Multiple sclerosis, fatigue, pathophysiology, treatment, measurement.

  4. The Future Multiple

    DEFF Research Database (Denmark)

    Spaniol, Matthew Jon; Rowland, Nicholas James

    2015-01-01

    Purpose – This paper asks “Why is the future in futures studies plural?” The attitude toward inquiry, based on post-actor-network theory (ANT) literature, positions philosophical questions about the ontological character of the future within the context of “planning” for it (i.e. in practice......). Multiplicity, as a post-ANT sensibility, helps one make sense of the empirical materials. This paper examines the possibility that rather than being alternatives to one another, plural futures and the singular future might co-exist in practice, and, thus, constitute a multiplicity. Design......, if “the future” were so preposterous an idea, then “futures” would cease to be a critical alternative to it. Futures needs the future; they are relationally bound together in a multiplicity. This paper considers what such a logical reality implies for a field that distances itself from the future and self...

  5. Identificatoin and confirmation of resistance against soybean aphid (Aphis glycines) in eight wild soybean lines

    Science.gov (United States)

    The development and use of aphid-resistant soybean (Glycine max) cultivars has been complicated by the presence of multiple virulent biotypes of the soybean aphid (SA, Aphis glycines Matsumura). Ultimately, a variety of unique resistance sources may be needed to develop cultivars with a broad spectr...

  6. [Analysis of 9 cases of nodular type of pulmonary cryptococcosis with coexisting lung cancer confirmed by pathological examinations].

    Science.gov (United States)

    Li, H Y; Lan, C Q; Weng, H; Chen, S X; Lin, Q H; Huang, J B

    2017-11-12

    Objective: To describe the characteristics of the nodular type of pulmonary cryptococcosis (PC) with coexisting lung cancer. Methods: A total of 9 cases of PC with coexisting lung cancer, admitted to Fuzhou Pulmonary Hospital of Fujian from 1st January 2009 to 31th December 2016, and confirmed by pathological examinations, were studied and the related literature were reviewed. Results: The patients consisted of 1 male and 8 females, with a mean age of (53±10) years (range, 38 to 68 years). Four patients (44.4%) had underlying diseases, 3 with diabetes mellitus and 1 with gastric cancer surgery. The main clinical manifestations of most cases were cough and phlegm. The lesions of PC on chest CT were mostly solitary or multiple nodules with a diameter death due to lung cancer metastasis and 1 case with lung cancer recurrence. Conclusions: Coexistence of PC and lung cancer is rare and the clinical symptoms are not specific. When PC coexists with carcinoma and manifests as pulmonary nodule, it mimics malignant lesions and is extremely easy to be misdiagnosed. Therefore PC must be considered in the differential diagnosis of pulmonary nodules.

  7. A CATALOG OF GALEX ULTRAVIOLET EMISSION FROM SPECTROSCOPICALLY CONFIRMED M DWARFS

    International Nuclear Information System (INIS)

    Jones, David O.; West, Andrew A.

    2016-01-01

    We present a catalog of Galaxy Evolution Explorer Near-UV (NUV) and Far-UV (FUV) photometry for the Palomar/MSU and SDSS DR7 spectroscopic M dwarf catalogs. The catalog contains NUV measurements matched to 577 spectroscopically confirmed M dwarfs and FUV measurements matched to 150 spectroscopically confirmed M dwarfs. Using these data, we find that NUV and FUV luminosities strongly correlate with Hα emission, a typical indicator of magnetic activity in M dwarfs. We also examine the fraction of M dwarfs with varying degrees of strong line emission at NUV wavelengths. Our results indicate that the frequency of M dwarf NUV emission peaks at intermediate spectral types, with at least ∼30% of young M4–M5 dwarfs having some level of activity. For mid-type M dwarfs, we show that NUV emission decreases with distance from the Galactic plane, a proxy for stellar age. Our complete matched source catalog is available online

  8. Primary ovary choriocarcinoma: individual DNA polymorphic analysis as a strategy to confirm diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Fernando Nalesso

    2013-04-01

    Full Text Available Primary choriocarcinoma of the ovary is rare. Furthermore, this tumor can arise from gestational tissue or pure germ cells of the ovary, with the latter resulting in non-gestational choriocarcinoma. While the clinical characteristics and histology of both tumor types are identical, differentiation of these tumors is necessary for effective treatment. One strategy for the differentiation of these tumors types is to assay for the presence of paternal DNA. Accordingly, in the present case, a patient with primary choriocarcinoma of the ovary with a non-gestational origin was confirmed by DNA analysis. The patient subsequently exhibited an excellent response to chemotherapy, and following surgery, achieved complete remission. A pathological analysis of surgical specimens further confirmed the absence of tumor.

  9. Manual on quality assurance for the survey, evaluation and confirmation of nuclear power plant sites

    International Nuclear Information System (INIS)

    1987-04-01

    The present Manual on Quality Assurance for the Survey, Evaluation and Confirmation of Nuclear Power Plant Sites contains supporting material and illustrates examples for implementing the requirements contained in the Code of Practice on Quality Assurance for Safety in Nuclear Power Plants to the activities of survey, evaluation and confirmation of nuclear power plant sites. At the same time the Code of Practice for Safety in Nuclear Power Plant Siting, and Safety Guides in the siting series contain requirements and recommendations to implement a quality assurance programme in selected activities of the siting process. This manual is intended to provide guidance and illustrate examples on this implementation. During preparation and reviews of this Manual it was found out that the methodology of implementation of the quality assurance programme in siting activities is still under development. For these reasons it was considered appropriate to publish this Manual as a temporary publication for trial use

  10. Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy.

    Science.gov (United States)

    O'Sullivan, Sean S; Djamshidian, Atbin; Ahmed, Zeshan; Evans, Andrew H; Lawrence, Andrew D; Holton, Janice L; Revesz, Tamas; Lees, Andrew J

    2010-04-15

    There is growing awareness of impulsive-compulsive spectrum behaviors (ICBs) in patients with Parkinson's disease (PD) treated with dopamine replacement therapy (DRT). These include pathological gambling, hypersexuality, compulsive shopping, binge eating, punding and compulsive use of DRT, or dopamine dysregulation syndrome. In PD, difficulties exist in separating the effects of DRT from the underlying disease process and aberrant dopaminergic systems in determining the aetiology of ICBs. Recent reports of ICBs associated with dopamine agonist use for conditions other than PD may suggest a significant etiological role for these medications, but currently published cases thus far lack pathological confirmation of diagnoses. We present three cases of pathologically confirmed progressive supranuclear palsy who developed ICBs in association with dopamine agonist use. Pathological comparisons between these three cases and other case series of progressive supranuclear palsy are made. (c) 2010 Movement Disorder Society.

  11. New instrument for the confirmation of declared power histories of central station nuclear power plants

    International Nuclear Information System (INIS)

    Dowdy, E.J.; Robba, A.A.; Hastings, R.D.; France, S.W.

    1979-01-01

    An operationally simple, portable, microprocessor-based, unattended reactor power monitor was developed for International Atomic Energy Agency inspector use in confirming operator records of the power history of nuclear power plants. The monitor is based on the principle that the leakage neutron flux outside the biological shield is proportional to the thermal power level. The leakage flux is detected and compared with the leakage flux from the same reactor for a confirmed calibration period. Several output options are available, and a record of more than three months of hourly measurements of the themal power of the plant can be obtained. The monitor has battery backup power for interruptions of host power of duration up to 18 hours

  12. The first case of laboratory-confirmed dengue virus infection in Mimika, Papua province, Indonesia

    Directory of Open Access Journals (Sweden)

    Agustiningsih Agustiningsih

    2016-07-01

    Full Text Available Abstrak Latar belakang: Dengue merupakan penyakit bersumber vektor yang berkontribusi cukup besar dalam menyebabkan masalah kesehatan baik di negara tropis maupun subtropis. Hingga saat ini virus dengue telah menyebar ke seluruh provinsi di Indonesia sejak pertama kali ditemukan di Surabaya pada tahun 1968. Kabupaten Mimika di propinsi Papua, Indonesia, merupakan daerah non-endemis dengue dan tidak pernah melaporkan munculnya kasus dengue. Walau begitu, pada tahun 2012 ditemukan 13 kasus tersangka dengue yang dirawat di Rumah Sakit Umum di Mimika. Studi ini bertujuan memberi gambaran karakteristik genetik virus dengue dari kasus terkonfirmasi (laboratory-confirmed pertama di kabupaten Mimika, propinsi Papua, Indonesia. Metode: Isolasi virus pada sel nyamuk C6/36, RT-PCR dan penentuan serotipe dilakukan untuk mengkonfirmasi adanya virus dengue (DENV di dalam serum pasien tersangka dengue dari kabupaten Mimika, propinsi Papua, Indonesia. Sekuensing dan analisis pohon filogenetik terhadap complete-coding sequence (CDS gen E dilakukan terhadap sampel yang telah positif DENV untuk penentuan genotipe virus. Hasil: Sebanyak 4 kasus tersangka dengue terkonfirmasi positif DENV berdasarkan pemeriksaan RT-PCR, sedangkan 2 sampel berhasil dilakukan kultur pada sel C6/36. Hasil penentuan serotipe menunjukkan bahwa virus DENV dari kabupaten Mimika, propinsi Papua, Indonesia, termasuk ke dalam serotipe DENV 3.  Analisis CDS gen E menunjukkan DENV 3 termasuk ke dalam genotipe I. Kesimpulan: Studi ini melaporkan kasus pertama dengue yang terkonfirmasi secara laboratorium dari kabupaten Mimika, propinsi Papua, Indonesia, yang merupakan daerah non-endemis dengue. Kata Kunci: dengue, penentuan serotipe, penentuan genotipe, kabupaten Mimika Abstract Background: Dengue is the most important vector-borne disease that poses serious health problem both in tropical and subtropical countries. Since the first outbreak in Surabaya in 1968, dengue infection has spread in

  13. Experimental confirmation of the atomic force microscope cantilever stiffness tilt correction

    Science.gov (United States)

    Gates, Richard S.

    2017-12-01

    The tilt angle (angle of repose) of an AFM cantilever relative to the surface it is interrogating affects the effective stiffness of the cantilever as it analyzes the surface. For typical AFMs and cantilevers that incline from 10° to 15° tilt, this is thought to be a 3%-7% stiffness increase correction. While the theoretical geometric analysis of this effect may have reached a consensus that it varies with cos-2 θ, there is very little experimental evidence to confirm this using AFM cantilevers. Recently, the laser Doppler vibrometry thermal calibration method utilized at NIST has demonstrated sufficient stiffness calibration accuracy, and precision to allow a definitive experimental confirmation of the particular trigonometric form of this tilt effect using a commercial microfabricated AFM cantilever specially modified to allow strongly tilted (up to 15°) effective cantilever stiffness measurements.

  14. Freeman–Sheldon Syndrome: First Molecularly Confirmed Case from Sub-Saharan Africa

    Directory of Open Access Journals (Sweden)

    A. M. Ali

    2017-01-01

    Full Text Available We report a case of a male baby who has characteristic signs of Freeman–Sheldon syndrome, a rare but recognizable, severe autosomal dominant form of distal arthrogryposis. Diagnosis was based on the distinctive clinical characteristics of the syndrome and confirmed by genetic analysis that showed a de novo missense mutation c.2015G>A (p.Arg672His of the MYH3 gene. We highlight the different features present in our patient and describe the etiology of the Freeman–Sheldon phenotype and how its clinical complications can be dealt with. To the best of our knowledge, this is the first molecularly confirmed case of Freeman–Sheldon syndrome in sub-Saharan Africa.

  15. Radioimmunoassay screening and GC/MS confirmation of whole blood samples for drugs of abuse

    Energy Technology Data Exchange (ETDEWEB)

    Spiehler, V.R.; Sedgwick, P.

    From 1981 to 1984, an average of 300 radioimmunoassay screens on whole blood were performed each week in the authors laboratory. Most samples were screened for opiates phencyclidine and its analogs, barbiturates, and cocaine or its metabolite benzoylecgonine. A commercially available radioimmunoassay was used with modifications to facilitate screening of whole blood. Increasing sample size increased the sensitivity of the assay. Changing reagent concentration (1:1 dilution), incubation time, sample matrix (water, urine, or blood), or fraction counted (precipitate or supernatant) did not affect the utility of the standard curve or the sensitivity of the assay. All positive results for phencyclidine, opiates, cocaine, and related compounds were confirmed by GC/MA. Barbiturate positives were confirmed by UV spectrophotometry.

  16. Sentencing Multiple Crimes

    DEFF Research Database (Denmark)

    Roberts, Julian V.

    Most people assume that criminal offenders have only been convicted of a single crime. However, in reality almost half of offenders stand to be sentenced for more than one crime.The high proportion of multiple crime offenders poses a number of practical and theoretical challenges for the criminal......, and psychology offer their perspectives to the volume. A comprehensive examination of the dynamics involved with sentencing multiple offenders has the potential to be a powerful tool for legal scholars and professionals, particularly given the practical importance of the topic and the relative dearth of research...

  17. High-multiplicity processes

    International Nuclear Information System (INIS)

    Shelkov, G.; Sisakyan, A.; Mandzhavidze, I.

    1999-01-01

    We wish to demonstrate that investigation of asymptotically high multiplicity (AHM) hadron reactions may solve, or at least clear up, a number of problems unsolvable by other ways. We would lean upon the idea: (i) the reactions final state entropy is proportional to multiplicity and, by this reason, just in the AHM domain one may expect the equilibrium final state and (ii) the AHM final state is cold because of the energy-momentum conservation laws. This means that the collective phenomena may become important in the AHM domain. The possibility of hard processes dominance is considered also

  18. Multiple Sclerosis in Children

    OpenAIRE

    INALOO, Soroor; HAGHBIN, Saideh

    2013-01-01

    How to Cite This Article: Inaloo S, Haghbin S. Multiple Sclerosis in Children. Iran J Child Neurol. 2013 Spring;7(2):1-10. Multiple sclerosis (MS) is the most important immune-mediated demyelinated disease of human which is typically the disease of young adults. A total of 4% to 5% of MS population are pediatric. Pediatric MS is defined as the appearance of MS before the age of sixteen. About 80% of the pediatric cases and nearly all adolescent onset patients present with attacks typical to a...

  19. Safe Dynamic Multiple Inheritance

    DEFF Research Database (Denmark)

    Ernst, Erik

    2002-01-01

    Multiple inheritance and similar mechanisms are usually only supported at compile time in statically typed languages. Nevertheless, dynamic multiple inheritance would be very useful in the development of complex systems, because it allows the creation of many related classes without an explosion ...... of operands the '&' operator fails; as a result, dynamic creation of new classes and methods was considered a dangerous operation in all cases. This paper presents a large and useful category of combinations, and proves that combinations in this category will always succeed....

  20. Host country employees’ ethnic identity confirmation: evidence from interactions with ethnically similar expatriates

    OpenAIRE

    Fan, Shea; Harzing, Anne-Wil

    2017-01-01

    Employing expatriates who share an ethnicity with host country employees (HCEs) is a widespread expatriate selection strategy. However, little research has compared how expatriates and HCEs perceive this shared ethnicity. Drawing upon an identity perspective, we propose HCEs’ ethnic identity confirmation, the level of agreement between how an HCE views the importance of his/her own ethnic identity and how expatriates view the importance of the HCE’s ethnic identity, affects HCEs’ attitudes to...

  1. Evaluation of three immunofluorescence assays for culture confirmation and typing of herpes simplex virus.

    OpenAIRE

    Lipson, S M; Schutzbank, T E; Szabo, K

    1987-01-01

    Three pairs of monoclonal antibodies, supplied in kits by Electro-Nucleonics, Inc. (ENI), The Syva Co., and Kallestad Laboratories, Inc. (KL), were evaluated for the laboratory confirmation and typing of herpes simplex virus (HSV). Of 108 coded HSV slide preparation, run in parallel with each monoclonal-antibody set, 103 were equivalent by the immunofluorescence assays. Among the five discordant isolates, three (2.8%) did not type with the KL monoclonal antibodies and two (1.9%) false-positiv...

  2. The PR Elections and Multipartyism in Romania. A Confirmation of M. Duverger’s Theory

    Directory of Open Access Journals (Sweden)

    Alexandru Radu

    2013-02-01

    Full Text Available This article aims to investigate the relationship between the type of the practiced electoral system and the format of the party system, using the theories voiced by M. Duverger, in order do negate the exceptional character of the postocommunist period in Romania. The analysis leads to the conclusion that, given this perspective, Romania is actually an exemplary case in confirming Duverger’s thesis on the relationship between the proportional electoral system and the multipartyism.

  3. Sonographic Identification of Tube Thoracostomy Study (SITTS: Confirmation of Intrathoracic Placement

    Directory of Open Access Journals (Sweden)

    Jamie A. Jenkins

    2012-09-01

    Full Text Available Introduction: Thoracostomy tubes (TT are commonly placed in the management of surgical, emergency, and trauma patients and chest radiographs (CXR and computed tomography (CT are performed to confirm placement. Ultrasound (US has not previously been used as a means to confirm intrathoracic placement of chest tubes. This study involves a novel application of US to demonstrate chest tubes passing through the pleural line, thus confirming intrathoracic placement.Methods: This was an observational proof-of-concept study using a convenience sample of patients with TTs at a tertiary-care university hospital. Bedside US was performed by the primary investigatorusing first the low-frequency (5–1 MHz followed by the high-frequency (10–5 MHz transducers, in both 2-dimensional gray-scale and M-modes in a uniform manner. The TTs were identified in transverse and longitudinal views by starting at the skin entry point and scanning to where the TT passed the pleural line, entering the intrathoracic region. All US images were reviewed by US fellowship-trained emergency physicians. CXRs and CTs were used as the standard for confirmation ofTT placement.Results: Seventeen patients with a total of 21 TTs were enrolled. TTs were visualized entering the intrathoracic space in 100% of cases. They were subjectively best visualized with the high-frequency (10–5 MHz linear transducer. Sixteen TTs were evaluated using M-mode. TTs produced a distinct pattern on M-mode.Conclusion: Bedside US can visualize the TT and its entrance into the thoracic cavity and it can distinguish it from the pleural line by a characteristic M-mode pattern. This is best visualized with the high-frequency (10–5 MHz linear transducer. [West J Emerg Med. 2012;13(4:305–311.

  4. Phylogeographic link between Sicilian and Corso-Sardinian Testudo h. hermanni confirmed

    Directory of Open Access Journals (Sweden)

    Gabriele Giacalone

    2009-12-01

    Full Text Available Our study confirms that Sicilian and Corso-Sardinian Testudo h. hermanni share a certain mtDNA haplotype, while tortoises from peninsular Italy harbour slightly different haplotypes. When the fossil record is considered, this striking pattern agrees well with the idea of local extinction in Corsica and Sardinia and later replacement by tortoises originating elsewhere, either by natural oversea dispersal or translocation by man.

  5. Federal Administrative Court confirms interim action for the Kruemmel power plant site

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    The interim action concerning the reactor site was confirmed in 1972, the action of voidance because of the possible injuriousness to health was rejected in the first instance. In the appeal OVG Lueneburg had sharpened three clauses concerning the contents of the restrictions and injunctions included in the interim action to the disadvantage of the operator. Responding to a new appeal the BVerwG has eliminated these restrictions and dismissed the following appeals of the plaintiffs. (HP) [de

  6. Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

    OpenAIRE

    Fivelman, Quinton L; Butcher, Geoffrey A; Adagu, Ipemida S; Warhurst, David C; Pasvol, Geoffrey

    2002-01-01

    Abstract We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone®. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was...

  7. THE SWIFT AGN AND CLUSTER SURVEY. II. CLUSTER CONFIRMATION WITH SDSS DATA

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, Rhiannon D.; Dai, Xinyu [Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, Norman, OK 73019 (United States); Kochanek, Christopher S. [Department of Astronomy, Ohio State University, Columbus, OH 43210 (United States); Bregman, Joel N., E-mail: Rhiannon.D.Griffin-1@ou.edu, E-mail: xdai@ou.edu, E-mail: ckochanek@astronomy.ohio-state.edu, E-mail: jbregman@umich.edu [Department of Astronomy, University of Michigan, Ann Arbor, MI 48109 (United States)

    2016-01-15

    We study 203 (of 442) Swift AGN and Cluster Survey extended X-ray sources located in the SDSS DR8 footprint to search for galaxy over-densities in three-dimensional space using SDSS galaxy photometric redshifts and positions near the Swift cluster candidates. We find 104 Swift clusters with a >3σ galaxy over-density. The remaining targets are potentially located at higher redshifts and require deeper optical follow-up observations for confirmation as galaxy clusters. We present a series of cluster properties including the redshift, brightest cluster galaxy (BCG) magnitude, BCG-to-X-ray center offset, optical richness, and X-ray luminosity. We also detect red sequences in ∼85% of the 104 confirmed clusters. The X-ray luminosity and optical richness for the SDSS confirmed Swift clusters are correlated and follow previously established relations. The distribution of the separations between the X-ray centroids and the most likely BCG is also consistent with expectation. We compare the observed redshift distribution of the sample with a theoretical model, and find that our sample is complete for z ≲ 0.3 and is still 80% complete up to z ≃ 0.4, consistent with the SDSS survey depth. These analysis results suggest that our Swift cluster selection algorithm has yielded a statistically well-defined cluster sample for further study of cluster evolution and cosmology. We also match our SDSS confirmed Swift clusters to existing cluster catalogs, and find 42, 23, and 1 matches in optical, X-ray, and Sunyaev–Zel’dovich catalogs, respectively, and so the majority of these clusters are new detections.

  8. Delay between pregnancy confirmation and sickle cell and thalassaemia screening: a population-based cohort study

    Science.gov (United States)

    Dormandy, Elizabeth; Gulliford, Martin C; Reid, Erin P; Brown, Katrina; Marteau, Theresa M

    2008-01-01

    Background Antenatal sickle cell and thalassaemia screening sometimes occurs too late to allow couples a choice regarding termination of affected fetuses. The target gestational age for offering the test in the UK is 10 weeks. Aim To describe the proportion of women screened before 70 days' (10 weeks') gestation and the delay between pregnancy confirmation in primary care and antenatal sickle cell and thalassaemia screening. Design of study Cohort study of reported pregnancies. Setting Twenty-five general practices in two UK inner-city primary care trusts offering universal screening. Method Anonymised data on all pregnancies reported to participating general practices was collected for a minimum of 6 months. Results There were 1441 eligible women intending to proceed with their pregnancies, whose carrier status was not known. The median (interquartile range [IQR]) gestational age at pregnancy confirmation was 7.6 weeks (6.0–10.7 weeks) and 74% presented before 10 weeks. The median gestational age at screening was 15.3 weeks (IQR = 12.6–18.0 weeks), with only 4.4% being screened before 10 weeks. The median delay between pregnancy confirmation and screening was 6.9 weeks (4.7–9.3 weeks) After allowing for practice level variation, there was no association between delay times and maternal age, parity, and ethnic group. Conclusion About 74% of women consulted for pregnancy before 10 weeks' gestation but fewer than 5% of women were screened before the target time of 10 weeks. Reducing the considerable delay between pregnancy confirmation in primary care and antenatal sickle cell and thalassaemia screening requires methods of organising and delivering antenatal care that facilitate earlier screening to be developed and evaluated. PMID:18318968

  9. Maxillary first molars with six canals confirmed with the aid of cone-beam computed tomography

    Directory of Open Access Journals (Sweden)

    Tahra Mohammad Al-Habboubi

    2016-01-01

    Full Text Available The maxillary first molar exhibits unpredictable root canal morphology. Different number of root canals has been reported with the aids of new tools. It is very important to clinically detect all canals for better outcome results. The purpose of the present case is to present a case of the maxillary first molar in a Saudi male patient with an anatomical variation of having six root canals that were confirmed with cone-beam computed tomography.

  10. Confirmation of root-knot nematode resistant gene Rmi1 using SSR markers

    Directory of Open Access Journals (Sweden)

    Musarrat Ramzan

    2017-02-01

    Full Text Available Background: The Root Knot Nematode (RKN is a serious economic threat to various cultivated crops worldwide. It is a devastating pest of soybean and responsible to cause severe yield loss in Pakistan. The cultivation of resistant soybean varieties against this pest is the sustainable strategy to manage the heavy loss and increase yield. There is an utmost need to identify RKN resistant varieties of soybean against cultivated in Pakistan. The presented study is an attempt to identify and confirm the presence of resistant gene Rmi1 in soybean. Method: Molecular studies have been done using Simple Sequence Repeat (SSR marker system to identify resistant soybean varieties against Root Knot Nematode (RKN using fifteen (15 indigenous cultivars and four (4 US cultivars. DNA was isolated, purified, quantified and then used to employ various SSR markers. The amplified product is observed using gel documentation system after electrophoresis. Results: Diagnostic SSR markers Satt-358 and Satt-492 have shown the presence of Rmi1 gene in all resistance carrying genotypes. Satt-358 amplified the fragment of 200 bp and Satt-492 generated 232 bp bands in all resistant genotypes. This study confirmed the Rmi gene locus (G248A-1 in all internationally confirmed resistant including six (6 native varieties. Conclusion: These investigations have identified six (6 resistant cultivars revealing the effective and informative sources that can be utilized in breeding programs for the selection of RKN resistance soybean genotypes in Pakistan.

  11. A SUCCESSFUL BROADBAND SURVEY FOR GIANT Ly{alpha} NEBULAE. II. SPECTROSCOPIC CONFIRMATION

    Energy Technology Data Exchange (ETDEWEB)

    Prescott, Moire K. M. [Department of Physics, University of California, Broida Hall, Mail Code 9530, Santa Barbara, CA 93106 (United States); Dey, Arjun; Jannuzi, Buell T., E-mail: mkpresco@physics.ucsb.edu [National Optical Astronomy Observatory, 950 North Cherry Avenue, Tucson, AZ 85719 (United States)

    2013-01-01

    Using a systematic broadband search technique, we have carried out a survey for large Ly{alpha} nebulae (or Ly{alpha} {sup b}lobs{sup )} at 2 {approx}< z {approx}< 3 within 8.5 deg{sup 2} of the NOAO Deep Wide-Field Survey Booetes field, corresponding to a total survey comoving volume of Almost-Equal-To 10{sup 8} h {sup -3} {sub 70} Mpc{sup 3}. Here, we present our spectroscopic observations of candidate giant Ly{alpha} nebulae. Of 26 candidates targeted, 5 were confirmed to have Ly{alpha} emission at 1.7 {approx}< z {approx}< 2.7, 4 of which were new discoveries. The confirmed Ly{alpha} nebulae span a range of Ly{alpha} equivalent widths, colors, sizes, and line ratios, and most show spatially extended continuum emission. The remaining candidates did not reveal any strong emission lines, but instead exhibit featureless, diffuse, blue continuum spectra. Their nature remains mysterious, but we speculate that some of these might be Ly{alpha} nebulae lying within the redshift desert (i.e., 1.2 {approx}< z {approx}< 1.6). Our spectroscopic follow-up confirms the power of using deep broadband imaging to search for the bright end of the Ly{alpha} nebula population across enormous comoving volumes.

  12. Is magnification necessary to confirm visual inspection of cervical abnormalities? A randomized trial in Peru

    Directory of Open Access Journals (Sweden)

    Jennifer L. Winkler

    2008-01-01

    Full Text Available OBJECTIVES: Cervical cancer is the leading cause of cancer death among women in developing countries. This study was designed to evaluate whether visual inspection with acetic acid and magnification (VIAM improved confirmation of cervical lesions as compared to confirmation with visual inspection with acetic acid (VIA without magnification when used by physicians. METHODS: From April-December 2004, women in San Martin, Peru, who were referred as VIA-positive by an "obstetriz" (a professional midwife with 6 years of university training were randomized into two groups for confirmatory screening by a physician using either VIA or VIAM with an AviScope,TM a hand-held 4x magnification scope with a green light source. The reference standard for the presence or absence of cervical neoplasia was colposcopy and directed biopsy, as required. RESULTS: A total of 358 women participated in the study; 161 had a confirmatory examination with VIAM and 159 with VIA. Sensitivity for low- or high-grade lesions was 68% with VIA and 77% with VIAM, and specificity was 62% with VIA and 63% with VIAM; however, these differences were not statistically significant. CONCLUSIONS: For settings where physician confirmation of cervical abnormalities identified through visual inspection is required and available, this study demonstrates that VIAM had no significant advantage over VIA.

  13. Is magnification necessary to confirm visual inspection of cervical abnormalities? A randomized trial in Peru.

    Science.gov (United States)

    Winkler, Jennifer L; Lewis, Kristen; Del Aguila, Roberto; Gonzales, Miguel; Delgado, José Manuel; Tsu, Vivien D; Sellors, John W

    2008-01-01

    Cervical cancer is the leading cause of cancer death among women in developing countries. This study was designed to evaluate whether visual inspection with acetic acid and magnification (VIAM) improved confirmation of cervical lesions as compared to confirmation with visual inspection with acetic acid (VIA) without magnification when used by physicians. From April-December 2004, women in San Martin, Peru, who were referred as VIA-positive by an "obstetriz" (a professional midwife with 6 years of university training) were randomized into two groups for confirmatory screening by a physician using either VIA or VIAM with an AviScope, a hand-held 4x magnification scope with a green light source. The reference standard for the presence or absence of cervical neoplasia was colposcopy and directed biopsy, as required. A total of 358 women participated in the study; 161 had a confirmatory examination with VIAM and 159 with VIA. Sensitivity for low- or high-grade lesions was 68% with VIA and 77% with VIAM, and specificity was 62% with VIA and 63% with VIAM; however, these differences were not statistically significant. For settings where physician confirmation of cervical abnormalities identified through visual inspection is required and available, this study demonstrates that VIAM had no significant advantage over VIA.

  14. Implementation of the Fissile Mass Flow Monitor Source Verification and Confirmation

    International Nuclear Information System (INIS)

    Uckan, Taner; March-Leuba, Jose A.; Powell, Danny H.; Nelson, Dennis; Radev, Radoslav

    2007-01-01

    This report presents the verification procedure for neutron sources installed in U.S. Department of Energy equipment used to measure fissile material flow. The Fissile Mass Flow Monitor (FMFM) equipment determines the 235 U fissile mass flow of UF 6 gas streams by using 252 Cf neutron sources for fission activation of the UF 6 gas and by measuring the fission products in the flow. The 252 Cf sources in each FMFM are typically replaced every 2 to 3 years due to their relatively short half-life (∼ 2.65 years). During installation of the new FMFM sources, the source identity and neutronic characteristics provided by the manufacturer are verified with the following equipment: (1) a remote-control video television (RCTV) camera monitoring system is used to confirm the source identity, and (2) a neutron detection system (NDS) is used for source-strength confirmation. Use of the RCTV and NDS permits remote monitoring of the source replacement process and eliminates unnecessary radiation exposure. The RCTV, NDS, and the confirmation process are described in detail in this report.

  15. Development of design window evaluation and display system. 1. System development and performance confirmation

    International Nuclear Information System (INIS)

    Muramatsu, Toshiharu; Yamaguchi, Akira

    2003-07-01

    Purpose: The work was performed to develop a design window evaluation and display system for the purpose of obtaining the effects of various design parameters on the typical thermal hydraulic issues resulting from a use of various kind of working fluid etc. easily. Method: The function of the system were 'confirmation of design margin' of the present design, 'confirmation of the affected design zone' when a designer changed some design parameter, and search for an design improvement' for design optimization. The system was developed using existing soft wares on PC and the database relating analytical results of typical thermal hydraulic issues provided by separate work. Results: (1) System design: In order to develop a design window evaluation and display system, 'numerical analysis unit', 'statistical analysis unit', 'MMI unit', 'optimization unit' were designed based on the result of selected optimization procedure and display visualization. Further, total system design was performed combining these units. Typical thermal hydraulic issues to be considered are upper plenum thermal hydraulics, thermal stratification, free surface sloshing, flow-induced vibration of a heat exchanger and thermal striping in the T-junction piping systems. (2) Development of prototype system and a functional check: A prototype system of a design window evaluation and display system was developed and the functions were confirmed as was planned. (author)

  16. Lessons learned from the CEOG generic accident management guidelines confirmation (validation) exercise

    International Nuclear Information System (INIS)

    Khalil, Y.F.; Schneider, R.E.; Greene, M.A.

    1996-01-01

    In July 1995, the CE Owner's Group completed and issued Revision 0 of the Generic Accident Management Guidelines (AMG's) to the owners group task participants. This guidance provides a structured mechanism for the plant staff at CE utilities to respond to accidents that beyond the plant design basis and, possibly, the Emergency Operating Procedures. Prior to final issue of the generic AMGs, the CEOG conducted an AMG Confirmation Exercise to establish the ability of the AMGs to fulfill this important role. The specific objectives of the AMG Confirmation Exercise were to (1) clarify the interactions and transitions between the AMG/Technical Support Center (TSC) and the EOPS/Operations Personnel (2) validate the adequacy of the AMG data collection and plant condition diagnostic evaluation process and (3) assess the feasibility of the mechanical material and recommendations contained in the AMG's. The purpose of paper is to provide a detailed description of the AMG Confirmation Exercise as well as important lessons learned during the planning and implementation of the exercise. In addition, a discussion will be presented pertaining to the relationship between the AMG's (incumbent to the Technical Support Center) and the plants Emergency Operating Procedures (incumbent to the Control Room Operations Staff)

  17. Intensive care nursing students' perceptions of simulation for learning confirming communication skills: A descriptive qualitative study.

    Science.gov (United States)

    Karlsen, Marte-Marie Wallander; Gabrielsen, Anita Kristin; Falch, Anne Lise; Stubberud, Dag-Gunnar

    2017-10-01

    The aim of this study was to explore intensive care nursing students experiences with confirming communication skills training in a simulation-based environment. The study has a qualitative, exploratory and descriptive design. The participants were students in a post-graduate program in intensive care nursing, that had attended a one day confirming communication course. Three focus group interviews lasting between 60 and 80min were conducted with 14 participants. The interviews were transcribed verbatim. Thematic analysis was performed, using Braun & Clark's seven steps. The analysis resulted in three main themes: "awareness", "ice-breaker" and "challenging learning environment". The participants felt that it was a challenge to see themselves on the video-recordings afterwards, however receiving feedback resulted in better self-confidence in mastering complex communication. The main finding of the study is that the students reported improved communication skills after the confirming communication course. However; it is uncertain how these skills can be transferred to clinical practice improving patient outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. On confirmation of abandonment of imported waste (glass solidified bodies) outside business places

    International Nuclear Information System (INIS)

    1996-01-01

    Electric power companies entrust the reprocessing of spent fuel generated from nuclear power stations to COGEMA in France, and in April, 1995, 28 high level radioactive wastes (glass solidified bodies) generated by the reprocessing were returned. When these glass solidified wastes are abandoned in the waste management facility of Japan Nuclear Fuel Service Co., it was decided to receive the confirmation of the prime minister on the measures based on the relevant law. Four electric power companies submitted the application and the explanation paper. As to the contents of the glass solidified wastes, the technical inspection was carried out by Bureau Veritas. Considering that this import of glass solidified wastes is the first in Japan, Science and Technology Agency carried out the measurement of all 28 wastes. The results are reported. It was confirmed that the measures for the abandonment taken by four electric power companies conform to the stipulation. The contents of the confirmation are reported in the order of the stipulation. These wastes were solidified with borosilicate glass in 5 mm thick stainless steel vessels, and the welding was done properly. (K.I.)

  19. [Multiple congenital tarsal synostoses].

    Science.gov (United States)

    Saadaoui, H

    1996-11-01

    Tarsal coalition is an abnormal fusion of two or more tarsal centers. Talo-calcaneal and calcaneo-navicular coalition are the most frequent types. If multiple tarsal coalition is suspected, computed tomography with sagittal reconstruction is the best method for diagnosis.

  20. Multiple sex partner

    African Journals Online (AJOL)

    User

    performance, knowledge, and attitude toward sex were risk factors for students having sex. However, risk factors for multiple sex partners included working in a places of .... education. Premarital sex and commercial sex were considered unacceptable by 89 vs. 94% of females and 79% vs 88% of male students respectively.

  1. Reduced multiplication modules

    Indian Academy of Sciences (India)

    if M is a von Neumann regular module (VNM); i.e., every principal submodule of M is a summand submodule. Also if M is an injective R-module, then M is a VNM. Keywords. Multiplication module; reduced module; minimal prime submodule;. Zariski topology; extremally disconnected. 1. Introduction. In this paper all rings are ...

  2. Multiple Access Communications

    DEFF Research Database (Denmark)

    This book constitutes the proceedings of the 9th International Workshop on Multiple Access Communications, MACOM 2016, held in Aalborg, Denmark, in November 2016. The 10 full papers presented in this volume were carefully reviewed and selected from 12 submissions. They were organized in topical...... sections named: physical layer aspects; MAC layer aspects; and information theory....

  3. Multiple Primary Tumors

    African Journals Online (AJOL)

    2017-12-05

    Dec 5, 2017 ... Multiple primary tumors occur in clinical practice causing diagnostic dilemma. It ... KEYWORDS: Carcinoid, colorectal cancer, metachronous, synchronous .... layer of the colon. The tumor cells are strongly positive to chromagranin and AE1/AE3. Features are those of carcinoid tumor of the colon. She was ...

  4. Zinc in multiple sclerosis

    DEFF Research Database (Denmark)

    Bredholt, Mikkel; Fredriksen, Jette Lautrup

    2016-01-01

    In the last 35 years, zinc (Zn) has been examined for its potential role in the disease multiple sclerosis (MS). This review gives an overview of the possible role of Zn in the pathogenesis of MS as well as a meta-analysis of studies having measured Zn in serum or plasma in patients with MS...

  5. Multiple Chemical Sensitivity

    DEFF Research Database (Denmark)

    Junge, Anne Gram

    Et voksende antal mennesker i Danmark oplever at være overfølsomme over for dufte og kemikalier. Imidlertid er den tilskrevne diagnose Multiple Chemical Sensitivity (MCS) ikke medicinsk anerkendt i Danmark pga. mangel på organiske og patofysiologisk basis for symptomerne. Dette speciale bygger på...

  6. Multiple chemical sensitivity

    DEFF Research Database (Denmark)

    Tran, Marie Thi Dao; Arendt-Nielsen, Lars; Kupers, Ron

    2013-01-01

    BACKGROUND: Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by recurrent, non-specific symptoms in response to chemically unrelated exposures in non-toxic concentrations. Although the pathophysiology of MCS remains unknown, central sensitization may be an important factor...

  7. Radiation Therapy - Multiple Languages

    Science.gov (United States)

    ... W XYZ List of All Topics All Radiation Therapy - Multiple Languages To use the sharing features on this page, ... Information Translations Vietnamese (Tiếng Việt) Expand Section Radiation Therapy - Tiếng Việt (Vietnamese) ... Health Information Translations Characters not displaying correctly on this page? See language display issues . Return to the MedlinePlus Health Information ...

  8. [Smoldering multiple myeloma].

    Science.gov (United States)

    Fouquet, G; Guidez, S; Herbaux, C; Demarquette, H; Leleu, X

    2014-04-01

    Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell neoplasia, characterized by monoclonal plasma cell proliferation in the absence of end-organ damage, but with a high risk of progression to multiple myeloma. It has therefore to be distinguished from monoclonal gammapathy of undetermined significance (MGUS), which has a much lower risk of progression, but also from multiple myeloma, which remains an incurable disease and requires a specific treatment. The critical question in the management of SMM is whether an early therapeutic strategy could help delaying the progression to multiple myeloma, in order to lower the risk of serious complications related to this progression, or even to cure the disease. This early treatment could not be proposed to all SMM patients, who are indeed asymptomatic, and in whom the risk of toxicity could make it difficult to justify the potential benefit obtained. The challenge is to target early at diagnosis SMM patients with a high risk of progression, using available routine tests sufficiently reliable to warrant the therapeutic sanction which relies on it. Today however, apart from randomized studies, recommendations are to maintain therapeutic abstention in SMM patients. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  9. Assessing Multiple Intelligences.

    Science.gov (United States)

    Martin, William C.

    This paper explains Howard Gardner's Theory of Multiple Intelligences (MI) and discusses questions raised about MI theory in regard to validity, assessment, and implications for instructional activities. MI theory asserts that human cognitive competence is best described in terms of a set of abilities, talents, and mental skills that each child…

  10. Body Weight - Multiple Languages

    Science.gov (United States)

    ... V W XYZ List of All Topics All Body Weight - Multiple Languages To use the sharing features on this page, ... PDF Health Information Translations Spanish (español) Expand Section Body Weight: MedlinePlus Health Topic - English ... Health Information Translations Characters not displaying correctly on this page? See language display issues . Return to the MedlinePlus Health Information ...

  11. [Delivery in multiple pregnancies].

    Science.gov (United States)

    Colla, F; D'Addato, F; Grio, R

    2001-04-01

    A knowledge of clinical physiognomy in pathologies related to multiple births is indispensable for improving maternal and feto-neonatal prognosis. This study is a contribution to the solution of this problem. A meta-analysis of data for multiple births at Department B of the Gynecology and Obstetrics Clinic at the University of Turi during the decade 1989-1998 was carried out, focusing on the arrangement and presentation of fetuses, the various types of birth, the gestational age at which birth occurred, the weight of neonates, neonatal mortality and maternal morbidity. Out of 11,523 births, there were a total of 194 (1.68%) multiple births, including 190 sets of twins and 4 triplets. 154 (79.38%) premature births were reported; 20 occurred 1500 g). The perinatal mortality rate was 3.82%. Maternal complications mainly occurred during the placental state, in the immediate postpartum and in puerperio. The authors feel that a more careful medical and social assistance, preventive hospitalisation, early recognition of the risk, constant monitoring for the optimal timing of birth, and lastly, qualified medical assistance during labour (expert gynecologist, trained obstetric staff) with other medical personnel (anesthetist, neonatal specialist) represent winning strategies to solve the problems arising during multiple pregnancies.

  12. Multiple Interactions in Herwig++

    CERN Document Server

    Bahr, Manuel; Seymour, Michael H.

    2008-01-01

    In this contribution we describe a new model of multiple partonic interactions that has been implemented in Herwig++. Tuning its two free parameters we find a good description of CDF underlying event data. We show extrapolations to the LHC and discuss intrinsic PDF uncertainties.

  13. Unfolding Fraction Multiplication

    Science.gov (United States)

    Wyberg, Terry; Whitney, Stephanie R.; Cramer, Kathleen A.; Monson, Debra S.; Leavitt, Seth

    2011-01-01

    Students often have difficulty understanding fractions, in general, and understanding how to multiply fractions, in particular. To move past this potential problem area, students need to develop a deeper understanding of multiplication and connect the ideas to fractions. In this article, the authors share their insights into teaching fraction…

  14. Multiple snapshot compressive beamforming

    DEFF Research Database (Denmark)

    Gerstoft, Peter; Xenaki, Angeliki; Mecklenbrauker, Christoph F.

    2015-01-01

    For sound fields observed on an array, compressive sensing (CS) reconstructs the multiple source signals at unknown directions-of-arrival (DOAs) using a sparsity constraint. The DOA estimation is posed as an underdetermined problem expressing the field at each sensor as a phase-lagged superposition...

  15. Multiple preequilibrium decay processes

    International Nuclear Information System (INIS)

    Blann, M.

    1987-11-01

    Several treatments of multiple preequilibrium decay are reviewed with emphasis on the exciton and hybrid models. We show the expected behavior of this decay mode as a function of incident nucleon energy. The algorithms used in the hybrid model treatment are reviewed, and comparisons are made between predictions of the hybrid model and a broad range of experimental results. 24 refs., 20 figs

  16. Information distance in multiples

    NARCIS (Netherlands)

    P.M.B. Vitányi (Paul)

    2009-01-01

    htmlabstractInformation distance is a parameter-free similarity measure based on compression, used in pattern recognition, data mining, phylogeny, clustering, and classification. The notion of information distance is extended from pairs to multiples (finite lists). We study maximal overlap,

  17. Multiple plots in R

    DEFF Research Database (Denmark)

    Edwards, Stefan McKinnon

    2012-01-01

    In this chapter I will investigate how to combine multiple plots into a single. The scenario is a dataset of a series of measurements, on three samples in three situations. There are many ways we can display this, e.g. 3d graphs or faceting. 3d graphs are not good for displaying static data so we...

  18. The Border Multiple

    DEFF Research Database (Denmark)

    of European borders by looking at border practices in the light of the mobility turn, and thus as dynamic, multiple, diverse and best expressed in everyday experiences of people living at and with borders, rather than focusing on static territorial divisions between states and regions at geopolitical level...

  19. Multiple Primary Cancer Monograph

    Science.gov (United States)

    To identify groups of cancer survivors that are at increased risk for multiple primary cancers, investigators led an effort to provide the first comprehensive population-based analysis of the risk of subsequent cancer in the U.S., resulting in a monograph.

  20. Multiple Primary Tumors

    African Journals Online (AJOL)

    2018-02-07

    Feb 7, 2018 ... Multiple primary tumors occur in clinical practice causing diagnostic dilemma. It ... KEYWORDS: Carcinoid, colorectal cancer, metachronous, synchronous .... layer of the colon. The tumor cells are strongly positive to chromagranin and AE1/AE3. Features are those of carcinoid tumor of the colon. She was ...

  1. Multiplication on Rn -A ...

    Indian Academy of Sciences (India)

    topological group except the associative law. So, (S7,.) is a ... the identity mapping. Clearly, each topological groupoid is an H-space. In par- ticular, (So, .), (S1, .), (S3,.) and (S7,.) are H-spaces. The following theorem is about the converse (see H usemoller, pp.202 in ... ]Rn \\ {O} be a multiplication with identity e. Define j1 :.

  2. Multiple unilateral renal cysts in two children

    International Nuclear Information System (INIS)

    Dugougeat, F.; Navarro, O.; Daneman, A.; Soares Souza, A.; Geary, D.

    2000-01-01

    We report two children who presented with multiple renal cysts involving only one kidney and in whom there was no family history of renal disease and who did not have syndromes known to be associated with renal cystic disease. This unilateral involvement may represent a distinct entity, which has only been previously described in three cases; however, long-term follow-up will be needed to confirm this hypothesis. We illustrate the sonographic and computed tomographic findings, and the differential diagnosis is discussed. (orig.)

  3. Computational simulations of frictional losses in pipe networks confirmed in experimental apparatusses designed by honors students

    Science.gov (United States)

    Pohlman, Nicholas A.; Hynes, Eric; Kutz, April

    2015-11-01

    Lectures in introductory fluid mechanics at NIU are a combination of students with standard enrollment and students seeking honors credit for an enriching experience. Most honors students dread the additional homework problems or an extra paper assigned by the instructor. During the past three years, honors students of my class have instead collaborated to design wet-lab experiments for their peers to predict variable volume flow rates of open reservoirs driven by gravity. Rather than learn extra, the honors students learn the Bernoulli head-loss equation earlier to design appropriate systems for an experimental wet lab. Prior designs incorporated minor loss features such as sudden contraction or multiple unions and valves. The honors students from Spring 2015 expanded the repertoire of available options by developing large scale set-ups with multiple pipe networks that could be combined together to test the flexibility of the student team's computational programs. The engagement of bridging the theory with practice was appreciated by all of the students such that multiple teams were able to predict performance within 4% accuracy. The challenges, schedules, and cost estimates of incorporating the experimental lab into an introductory fluid mechanics course will be reported.

  4. A Case of Multiple Spontaneous Keloid Scars

    Directory of Open Access Journals (Sweden)

    Abdulhadi Jfri

    2015-07-01

    Full Text Available Keloid scars result from an abnormal healing response to cutaneous injury or inflammation that extends beyond the borders of the original wound. Spontaneous keloid scars forming in the absence of any previous trauma or surgical procedure are rare. Certain syndromes have been associated with this phenomenon, and few reports have discussed the evidence of single spontaneous keloid scar, which raises the question whether they are really spontaneous. Here, we present a 27-year-old mentally retarded single female with orbital hypertelorism, broad nasal bridge, repaired cleft lip and high-arched palate who presented with progressive multiple spontaneous keloid scars in different parts of her body which were confirmed histologically by the presence of typical keloidal collagen. This report supports the fact that keloid scars can appear spontaneously and are possibly linked to a genetic factor. Furthermore, it describes a new presentation of spontaneous keloid scars in the form of multiple large lesions in different sites of the body.

  5. Multiple hepatic hemangiomas in a Nigerian man

    Directory of Open Access Journals (Sweden)

    Abiodun Christopher Jemilohun

    2017-12-01

    Full Text Available Hepatic hemangiomas are benign tumors of the liver which are often found incidentally. We present a 34-years-old man with a two-month history of upper abdominal pain and incidental finding of multiple hepatic masses. The patient sought medical attention at several healthcare facilities where he posed a diagnostic dilemma before he was referred to us. Computed tomographic scan revealed four hypodense hepatic nodules of varying sizes. The nodules demonstrated peripheral enhancement with progressive centripetal filling till they were totally filled during the delayed phase. Abdominal ultrasonography confirmed the four hepatic lesions. The largest lesion was in the left lobe measuring 73×72 mm while the smallest was in the right lobe (24×20 mm. All the masses demonstrated increased vascularity on color Doppler imaging. The paucity of reported cases of hepatic hemangioma in Nigeria, the multiplicity of the tumor and the giant size of one of them make this case remarkable and reportable.

  6. Multiple-target tracking with radar applications

    Science.gov (United States)

    Blackman, S. S.

    The theory and evaluation methods for the design of multiple target tracking (MTT) systems are examined. The Kalman and fixed-gain filtering, techniques for adaptive filtering, and the selection of tracking coordinate systems for filtering and prediction are described. Gating and data association techniques, measurement formation and processing for MTT, and methods for track confirmation and deletion are discussed. MTT system evaluation procedures including covariance analysis, Markov chain techniques, and Monte Carlo simulation are investigated. The derivation of a maximum likelihood expression for MTT data association, and the Bayesian methods of multiple hypothesis tracking and all-neighbors data association approach are analyzed. Group tracking techniques applicable for closely spaced targets such as large aircraft formations, the use of the agile beam capabilities of the radar electronically scanned antenna for MTT systems, an algorithm for the assignment problem of MTT data association, processing in a many-target-return environment, and MTT and artificial intelligence system architecture are studied.

  7. Note: sensitivity multiplication module for quartz crystal microbalance applications.

    Science.gov (United States)

    Burda, Ioan; Silaghi, Andreea; Tunyagi, Arthur; Simon, Simion; Popescu, Octavian

    2014-02-01

    In this Note, a novel sensitivity multiplication module was added to classical quartz crystal microbalance (QCM). The purpose is to increase QCM frequency shift without changing nominal frequency of the quartz crystal resonator or nominal frequency value delivered to the frequency counter. Allan deviance measurement confirms that the multiplication of the frequency shift is limited by the quartz crystal loads with direct effect in quartz crystal quality factor and oscillator stability. An experimental implementation of this new sensitivity multiplication module that can increase up to six times the frequency shift of the QCM was experimentally investigated using different load conditions.

  8. Smoking Status Confirmation by Proxy: Validation in a Smoking Cessation Trial

    Science.gov (United States)

    Reid, Zachary Z.; Kelley, Jennifer H. K.; Reyen, Michele; Korotkin, Molly; Japuntich, Sandra J.; Viana, Joseph C.; Levy, Douglas E.; Rigotti, Nancy A.

    2016-01-01

    Introduction: Biochemical confirmation (BC) of self-report is the gold standard of evidence for abstinence in smoking cessation research, but difficulty in obtaining samples may bias estimates of quit rates. Proxy confirmation (PC) has not been validated in cessation trials. We assessed the feasibility and validity of PC in a cessation trial for hospitalized smokers. Methods: We enrolled 402 daily cigarette smokers during a hospital admission. At enrollment, participants provided demographics, smoking history, and named proxies to confirm their smoking status at follow-up. Participants provided self-reported (SR) 7-day tobacco abstinence by telephone at 6 months post-discharge. SR quitters were asked to mail a saliva sample for BC. Incentives were offered for survey completion ($20) and returned samples ($50). We called proxies for all those with SR to obtain PC. Quit rates were calculated with missing data indicating smoking. We assessed associations of nonresponse with baseline characteristics using chi-squared tests and logistic regression. We calculated the sensitivity and specificity of PC in detecting smokers as determined by BC. Results: All patients named at least one proxy. Response rates were 82% for SR, 84% for PC, and 69% for BC. Observed participant characteristics were unrelated to provision of sample for BC. Estimated quit rates were 35% for SR, 27% for SR + PC, 21% for SR + BC and 27% for SR + BC or PC. Sensitivity of PC was not higher than SR (73% vs. 77%); specificity was lower (84% vs. 100%). Conclusion: PC was feasible but not superior to self-report in a cessation trial. PMID:25847290

  9. Integrity confirmation tests and post-irradiation test plan of the HTTR first-loading fuel

    International Nuclear Information System (INIS)

    Sawa, Kazuhiro; Sumita, Junya; Ueta, Shouhei; Suzuki, Shuichi; Tobita, Tsutomu; Saito, Takashi; Minato, Kazuo; Koya, Toshio; Sekino, Hajime

    2001-01-01

    Since the first-loading fuel of the High Temperature Engineering Test Reactor (HTTR) is the first mass-production High Temperature Gas-cooled Reactor (HTGR) fuel in Japan, their quality should be carefully inspected. For the quality control related to the fabrication process, Japan Atomic Energy Research Institute (JAERI) carried out the tests to certify the fuel integrity during operation. The tests comprise (1) as-fabricated SiC failure fraction measurement, (2) high-temperature heatup test of irradiated fuel and (3) accelerated irradiation test. For (1), the SiC failure fraction was measured independently in JAERI in addition to the measurement in the fabrication process. The measure failure fractions agreed within 95% confidence limit. In order to confirm the integrity of the SiC layer with respect to the 1,600degC criterion, the high-temperature heatup test of irradiated fuel compact was carried out. The results showed that no failed particle was present in the fuel compact after hating. The diffusion coefficient of metallic fission products in SiC layer was also examined in a series of post-irradiation heating tests. The measure diffusion coefficient of 137 Cs showed a good holding ability as those obtained for research and development fuel specimen. The measured fission gas release rate in accelerated irradiation test showed no additional failure up to 60 GWd/t which was about two times higher than 3 GWd/t of the maximum burnup in the HTTR core. Through the tests, integrity of as-fabricated first-loading fuel of the HTTR was finally confirmed. The future post-irradiation test plan, which will be carried out to confirm the fuel irradiation performance and to obtain the data on its irradiation characteristics in the core, is also described. (author)

  10. Mediastinal Synovial Sarcoma: Clinicopathologic Analysis of 21 Cases With Molecular Confirmation.

    Science.gov (United States)

    B S P Terra, Simone; Aesif, Scott W; Maleszewski, Joseph J; Folpe, Andrew L; Boland, Jennifer M

    2018-03-14

    Synovial sarcoma (SS), a translocation-associated sarcoma characterized by SS18-SSX1/2 fusion, presents most often in the extremities of young adults. While SS regularly occurs in the pleuropulmonary parenchyma, the mediastinum is an exceedingly rare primary site; the literature on this subject is predominantly composed of case reports and small series, mostly without molecular confirmation. Cases of mediastinal SS were selected from our institutional and consultation archives. Diagnoses were confirmed by either SS18 fluorescence in situ hybridization (n=6) or reverse transcription polymerase chain reaction for SS18-SSX1/2 (n=15). Mediastinal SSs occurred in 21 patients (15 men; mean age, 38 y; range, 21 to 75). Only 1 patient was older than 50 years. Average tumor size was 13.5 cm (range: 6.4 to 23 cm). One tumor was biphasic and the rest were monophasic, 11 of which were poorly differentiated (52%). Of 10 cases with known fusion transcripts, 6 had SS18-SSX2 and 4 had SS18-SSX1. Follow-up was known for 16 patients (mean: 18.9 mo; range: 5 to 45): 14 had local disease progression or recurrence, and 6 had metastasis. Death from disease occurred in 11 of 16 patients (69%) at 5 to 32 months, and 5 (36%) were alive with disease at last follow-up (6 to 45 mo). Mediastinal SS is a rare and aggressive malignancy most common in patients younger than 50 years. Most are monophasic and reach large size before detection. Poorly differentiated morphology is common. SS should be included in the differential diagnosis of spindle cell, biphasic and poorly differentiated mediastinal tumors. Because of the rarity of SS at this site, molecular testing is recommended to confirm the diagnosis.

  11. El Contrato de Confirming en el tráfico mercantil de 2014

    OpenAIRE

    Caballenas-Becerra, Fernando Ignacio

    2014-01-01

    El contrato de confirming es una modalidad contractual bancaria que proviene del mundo anglosajón que se empezó a utilizar en España por el Banco Santander en el año 1993 y con una importancia creciente. Este contrato no cuenta con normativa específica en nuestro ordenamiento jurídico por lo que me propongo conceptualizarlo por medio del análisis jurídico de los contratos que en 2014 están utilizando las principales entidades de crédito (Banco Santander, BBVA y Bankia). S...

  12. Attempt to confirm superheavy element production in the 48Ca +238U reaction

    Energy Technology Data Exchange (ETDEWEB)

    Gregorich, K.E.; Loveland, W.; Peterson, D.; Zielinski, P.M.; Nelson, S.L.; Chung, Y.H.; Dullmann, Ch.E.; Folden III, C.M.; Aleklett,K.; Eichler, R.; Hoffman D.C.; Omtvedt, J.P.; Pang, G.K.; Schwantes,J.M.; Soverna, S.; Sprunger, P.; Sudowe, R.; Wilson, R.E.; Nitsche, H.

    2005-03-24

    An attempt to confirm production of superheavy elements in the reaction of 48Ca beams with actinide targets has been performed using the 238U(48Ca,3n)283112 reaction. Two 48Ca projectile energies were used, that spanned the energy range where the largest cross sections have been reported for this reaction. No spontaneous fission events were observed. No alpha decay chains consistent with either reported or theoretically predicted element 112 decay properties were observed. The cross section limits reached are significantly smaller than the recently reported cross sections.

  13. Confirmation of a high magnetic field in GRO J1008-57

    DEFF Research Database (Denmark)

    Bellm, Eric C.; Fuerst, Felix; Pottschmidt, Katja

    2014-01-01

    GRO J1008-57 is a high-mass X-ray binary for which several claims of a cyclotron resonance scattering feature near 80 keV have been reported. We use NuSTAR, Suzaku, and Swift data from its giant outburst of 2012 November to confirm the existence of the 80 keV feature and perform the most sensitiv...... a fundamental at lower energies with optical depth larger than 5% of the 78 keV line. These results indicate that GRO J1008-57 has a magnetic field of 6.7 x 10(12)(1 + z) G, the highest among known accreting pulsars....

  14. The Consumer Motivation Scale: A detailed review of item generation, exploration, confirmation, and validation procedures

    Directory of Open Access Journals (Sweden)

    I. Barbopoulos

    2017-08-01

    Full Text Available This data article offers a detailed description of analyses pertaining to the development of the Consumer Motivation Scale (CMS, from item generation and the extraction of factors, to confirmation of the factor structure and validation of the emergent dimensions. The established goal structure – consisting of the sub-goals Value for Money, Quality, Safety, Stimulation, Comfort, Ethics, and Social Acceptance – is shown to be related to a variety of consumption behaviors in different contexts and for different products, and should thereby prove useful in standard marketing research, as well as in the development of tailored marketing strategies, and the segmentation of consumer groups, settings, brands, and products.

  15. Integrating technology readiness into the expectation-confirmation model: an empirical study of mobile services.

    Science.gov (United States)

    Chen, Shih-Chih; Liu, Ming-Ling; Lin, Chieh-Peng

    2013-08-01

    The aim of this study was to integrate technology readiness into the expectation-confirmation model (ECM) for explaining individuals' continuance of mobile data service usage. After reviewing the ECM and technology readiness, an integrated model was demonstrated via empirical data. Compared with the original ECM, the findings of this study show that the integrated model may offer an ameliorated way to clarify what factors and how they influence the continuous intention toward mobile services. Finally, the major findings are summarized, and future research directions are suggested.

  16. The Cretaceous Fossil Burmaculex antiquus Confirmed as the Earliest Known Lineage of Mosquitoes (Diptera: Culicidae).

    Science.gov (United States)

    Borkent, Art; Grimaldi, David A

    2016-02-15

    A second female of mid-Cretaceous Burmaculex antiquus Borkent & Grimaldi, preserved in 99 myo Burmese amber, and the oldest known member of the Culicidae, is described in detail. Although generally opaque and distorted, some character states are added or refined. The discovery of well-developed scales on the legs shows that this feature must now be considered a synapomorphy of both the fossil and all extant members of the family. Previously described synapomorphies and further interpretation here confirm the phylogenetic position of this fossil as the sister group to extant and all known fossil Culicidae. It is placed in the new subfamily Burmaculicinae.

  17. Genomic analyses confirm close relatedness between Rhodococcus defluvii and Rhodococcus equi (Rhodococcus hoagii).

    Science.gov (United States)

    Sangal, Vartul; Jones, Amanda L; Goodfellow, Michael; Hoskisson, Paul A; Kämpfer, Peter; Sutcliffe, Iain C

    2015-01-01

    Rhodococcus defluvii strain Ca11(T) was isolated from a bioreactor involved in extensive phosphorus removal. We have sequenced the whole genome of this strain, and our comparative genomic and phylogenetic analyses confirm its close relatedness with Rhodococcus equi (Rhodococcus hoagii) strains, which share >80 % of the gene content. The R. equi virulence plasmid is absent though most of the chromosomal R. equi virulence-associated genes are present in R. defluvii Ca11(T). These data suggest that although R. defluvii is an environmental organism, it has the potential to colonize animal hosts.

  18. Confirmation of an ARID2 defect in SWI/SNF-related intellectual disability.

    Science.gov (United States)

    Van Paemel, Ruben; De Bruyne, Pauline; van der Straaten, Saskia; D'hondt, Marleen; Fränkel, Urlien; Dheedene, Annelies; Menten, Björn; Callewaert, Bert

    2017-11-01

    We present a 4-year-old girl with delayed neuromotor development, short stature of prenatal onset, and specific behavioral and craniofacial features harboring an intragenic deletion in the ARID2 gene. The phenotype confirmed the major features of the recently described ARID2-related intellectual disability syndrome. However, our patient showed overlapping features with Nicolaides-Baraitser syndrome and Coffin-Siris syndrome, providing further arguments to reclassify these disorders as "SWI/SNF-related intellectual disability syndromes." © 2017 Wiley Periodicals, Inc.

  19. Minimum detection efficiency for the loophole-free confirmation of quantum contextuality

    International Nuclear Information System (INIS)

    Xiang Yang; Hong Fang-Yu

    2013-01-01

    Klyachko—Can—Binicioğlu—Shumovsky (KCBS) inequality is a Bell-like inequality, the violation of which can be used to confirm the existence of quantum contextuality. However, the imperfection of detection efficiency may cause the so-called loophole in actual KCBS's experiments. We derive an alternative KCBS inequality to deal with the loophole in actual KCBS's experiments. We prove that if the experimental data violate this KCBS inequality, the loophole-free violation of the original KCBS inequality will occur. We show that the minimum detection efficiency needed for a loophole-free violation of the KCBS inequality is about 0.9738

  20. Herpes simplex encephalitis: MRI findings in two cases confirmed by polymerase chain reaction assay

    International Nuclear Information System (INIS)

    Lee, J.W.; Kim, I.O.; Kim, W.S.; Yeon, K.M.; Lee, H.-J.; Hwang, Y.S.

    2001-01-01

    Herpes simplex virus (HSV) type I causes a fulminant necrotising meningoencephalitis distinguished from other encephalitides by its focal and often haemorrhagic nature. Specific antiviral therapy with acyclovir can significantly improve the prognosis. We present MRI findings of two cases of herpes simplex encephalitis (HSE) confirmed by PCR analysis, focusing on the serial changes after acyclovir therapy: gyral swelling, high signal intensity on T2-weighted images in the subfrontal region, temporal lobe and insula in the initial stage, then regional extension with enhancement and haemorrhage despite appropriate acyclovir therapy, and finally encephalomalacia and brain atrophy. (orig.)

  1. Confirmed results of the 248Cm(48Ca,4n)292116 experiment

    International Nuclear Information System (INIS)

    Patin, J B; Moody, K J; Stoyer, M A; Wild, J F; Shaughnessy, D A; Stoyer, N J

    2003-01-01

    The results of a detailed analysis performed on the data obtained in the 248 Cm( 48 Ca,4n) 292 116 reaction is presented. This analysis is independent of the original data analysis performed in Dubna in which three separate decay chains were found. Each decay chain began with an evaporation residue followed by three α decays and ended in a spontaneous fission event, all correlated in time and position. The analysis presented confirms that the three events are present in the data. A summary of the three events will be given as well as a description of the analysis performed

  2. Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria.

    Science.gov (United States)

    Fivelman, Quinton L; Butcher, Geoffrey A; Adagu, Ipemida S; Warhurst, David C; Pasvol, Geoffrey

    2002-02-08

    We report the first in vitro and genetic confirmation of Malarone (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.

  3. Plant data evaluation of performance confirmation test in HTTR after Tohoku-Pacific Ocean Earthquake

    International Nuclear Information System (INIS)

    Ono, Masato; Tochio, Daisuke; Shinohara, Masanori; Shimazaki, Yosuke; Yanagi, Shunki; Iigaki, Kazuhiko

    2012-01-01

    Tohoku-Pacific Ocean Earthquake occurred on March 11th 2011 and the earthquake intensity of an upper 5 on the Japanese scale was observed in Oarai town. HTTR conducted the confirmation test on cold state in order to ensure the facilities/instruments of reactor building operate normally. In this test, the plant data in the facilities/instruments start-up phase and continue steady operation phase were measured and compared with the previous operation data, and the soundness of facilities/instruments is evaluated. As a result, in after the earthquake, the facilities/instruments operate normally and the reactor cooling function of the HTTR were ensured. (author)

  4. Verification of the model of predisposition in triathlon – structural model of confirmative factor analysis

    Directory of Open Access Journals (Sweden)

    Lenka Kovářová

    2012-09-01

    Full Text Available BACKGROUND: The triathlon is a combination of three different types of sport – swimming, cycling, and running. Each of these requires different top level predispositions and complex approach to talent selection is a rather difficult process. Attempts to identify assumptions in the triathlon have so far been specific and focused only on some groups of predispositions (physiology, motor tests, and psychology. The latest studies missed the structural approach and were based on determinants of sport performance, theory of sports training and expert assessment. OBJECTIVE: The aim of our study was to verify the model of predisposition in the short triathlon for talent assessment of young male athletes age 17–20 years. METHODS: The research sample consisted of 55 top level triathletes – men, who were included in the Government supported sports talent programme in the Czech Republic at the age of 17–20 years. We used a confirmative factor analysis (FA and Path diagram to verify the model, which allow us to explain mutual relationships among observed variables. For statistical data processing we used a structure equating modeling (SEM by software Lisrel L88. RESULTS: The study confirms best structural model for talent selection in triathlon at the age of 17–20 years old men, which composed seventeen indicators (tests and explained 91% of all cross-correlations (Goodness of Fit Index /GFI/ 0.91, Root Mean Square Residual /RMSR/ 0.13. Tests for predispositions in triathlons were grouped into five items, three motor predispositions (swimming, cycling and running skills, aerobic and psychological predispositions. Aerobic predispositions showed the highest importance to the assumptions to the general factor (1.00; 0. Running predispositions were measured as a very significant factor (–0.85; 0.28 which confirms importance of this critical stage of the race. Lower factor weight showed clusters of swimming (–0.61; 0.63 and cycling (0.53; 0

  5. Extrahepatic biliary atresia with choledochal cyst: Prenatal MRI predicted and post natally confirmed: A case report

    Directory of Open Access Journals (Sweden)

    Madhavi Nori

    2013-01-01

    Full Text Available Extrahepatic biliary atresia (EHBA is an uncommon cause of neonatal jaundice. Antenatal Magnetic Resonance Imaging (MRI diagnosis of EHBA has not been published to the best of our knowledge till date. EHBA with cystic component is likely to be mistaken for choledochal cyst. A case that was antenatally predicted and postnatally confirmed by surgery and histopathology is being reported. All imaging signs are analyzed herewith. Imaging helps in the prediction of EHBA and also helps in early postnatal surgical referral which in turn improves the results of Kasai′s portoenterostomy.

  6. Professional carers' struggle to be confirmed. Narratives within the care of the elderly and disabled.

    Science.gov (United States)

    Forsgärde, Marianne; Westman, Berith; Jansson, Lilian

    2002-03-01

    Twenty-seven members of staff working in special types of housing in Sweden narrated 95 narratives about their experience of being in problematic situations during the working day. The narratives were interpreted using a phenomenological-hermeneutic approach inspired by the philosophy of Ricoeur. The narratives mainly concerned interactions with colleagues and very few narratives concerned interactions with residents and relatives. On the relationship level of communication there is evidence that many interactions among the staff, residents and relatives were of a receptive and disconfirming nature. The results indicate that the staff feel lonely, and struggled to maintain self-esteem and to be confirmed.

  7. Tuberculous myocarditis is not always fatal: Report of three confirmed cases with uneventful outcome

    Directory of Open Access Journals (Sweden)

    Fares Al-Jahdali

    2017-01-01

    Full Text Available Tuberculosis (TB is a leading cause of death worldwide. It can affect any organ. However, cardiac involvement is extremely rare. Anti-TB therapy has been proved to be effective and curative in majority of TB cases except TB myocarditis, where it is found to be fatal. We describe three cases with confirmed TB with impaired left ventricular systolic function and low ejection fraction. All three cases improved clinically and left ventricular function returned to normal within a few weeks after the commencement of TB therapy.

  8. Multiple myeloma: 2 case reports | Olayemi | Nigerian Journal of ...

    African Journals Online (AJOL)

    This is a report of multiple myeloma in first cousins from the Niger delta region of Nigeria.The first patient was a 60-year-old Negroid male with a 3-month history of productive cough, chest pain, fever and 1 month history of weight loss. The diagnosis was confirmed by greater than 50% neoplastic plasma cells in the bone ...

  9. Interferential therapy for detrusor hyperreflexia in multiple sclerosis.

    Science.gov (United States)

    Van Poppel, H; Ketelaer, P; Van DeWeerd, A

    1985-06-01

    Twenty patients with detrusor hyperreflexia in multiple sclerosis were treated for frequency, urgency and incontinence, or catheter bypassing by interferential currents applied on the lumbosacral spinal marrow. Although the mechanism of action is not totally understood, subjective and objective improvements were registered in most patients. Further investigations are needed to confirm these results and to explain the favorable effect of interferential therapy.

  10. Isothermal amplification of environmental DNA (eDNA for direct field-based monitoring and laboratory confirmation of Dreissena sp.

    Directory of Open Access Journals (Sweden)

    Maggie R Williams

    Full Text Available Loop-mediated isothermal amplification (LAMP of aquatic invasive species environmental DNA (AIS eDNA was used for rapid, sensitive, and specific detection of Dreissena sp. relevant to the Great Lakes (USA basin. The method was validated for two uses including i direct amplification of eDNA using a hand filtration system and ii confirmation of the results after DNA extraction using a conventional thermal cycler run at isothermal temperatures. Direct amplification eliminated the need for DNA extraction and purification and allowed detection of target invasive species in grab or concentrated surface water samples, containing both free DNA as well as larger cells and particulates, such as veligers, eggs, or seeds. The direct amplification method validation was conducted using Dreissena polymorpha and Dreissena bugensis and uses up to 1 L grab water samples for high target abundance (e.g., greater than 10 veligers (larval mussels per L for Dreissena sp. or 20 L samples concentrated through 35 μm nylon screens for low target abundance, at less than 10 veligers per liter water. Surface water concentrate samples were collected over a period of three years, mostly from inland lakes in Michigan with the help of a network of volunteers. Field samples collected from 318 surface water locations included i filtered concentrate for direct amplification validation and ii 1 L grab water sample for eDNA extraction and confirmation. Though the extraction-based protocol was more sensitive (resulting in more positive detections than direct amplification, direct amplification could be used for rapid screening, allowing for quicker action times. For samples collected between May and August, results of eDNA direct amplification were consistent with known presence/absence of selected invasive species. A cross-platform smartphone application was also developed to disseminate the analyzed results to volunteers. Field tests of the direct amplification protocol using a

  11. MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases.

    Science.gov (United States)

    Harper, Lorna; Fumagalli, Giorgio G; Barkhof, Frederik; Scheltens, Philip; O'Brien, John T; Bouwman, Femke; Burton, Emma J; Rohrer, Jonathan D; Fox, Nick C; Ridgway, Gerard R; Schott, Jonathan M

    2016-04-01

    Accurately distinguishing between different degenerative dementias during life is challenging but increasingly important with the prospect of disease-modifying therapies. Molecular biomarkers of dementia pathology are becoming available, but are not widely used in clinical practice. Conversely, structural neuroimaging is recommended in the evaluation of cognitive impairment. Visual assessment remains the primary method of scan interpretation, but in the absence of a structured approach, diagnostically relevant information may be under-utilized. This definitive, multi-centre study uses post-mortem confirmed cases as the gold standard to: (i) assess the reliability of six visual rating scales; (ii) determine their associated pattern of atrophy; (iii) compare their diagnostic value with expert scan assessment; and (iv) assess the accuracy of a machine learning approach based on multiple rating scales to predict underlying pathology. The study includes T1-weighted images acquired in three European centres from 184 individuals with histopathologically confirmed dementia (101 patients with Alzheimer's disease, 28 patients with dementia with Lewy bodies, 55 patients with frontotemporal lobar degeneration), and scans from 73 healthy controls. Six visual rating scales (medial temporal, posterior, anterior temporal, orbito-frontal, anterior cingulate and fronto-insula) were applied to 257 scans (two raters), and to a subset of 80 scans (three raters). Six experts also provided a diagnosis based on unstructured assessment of the 80-scan subset. The reliability and time taken to apply each scale was evaluated. Voxel-based morphometry was used to explore the relationship between each rating scale and the pattern of grey matter volume loss. Additionally, the performance of each scale to predict dementia pathology both individually and in combination was evaluated using a support vector classifier, which was compared with expert scan assessment to estimate clinical value

  12. Chronic progressive multiple sclerosis

    International Nuclear Information System (INIS)

    Buffoli, A.; Micheletti, E.; Capra, R.; Mattioli, F.; Marciano', N.

    1991-01-01

    A long-lasting immunological suppression action seems to be produced by total lymphoid irradiation; some authors emphasize the favorable effect of this treatment on chronic progressive multiple sclerosis. In order to evaluate the actual role of TLI, 6 patients affected with chronic progressive multiple sclerosis were submitted to TLI with shaped and personalized fields at the Istituto del Radio, University of Brescia, Italy. The total dose delivered was 19.8 Gy in 4 weeks, 1.8 Gy/day, 5d/w; a week elapsed between the first and the second irradiation course. Disability according to Kurtzke scale was evaluated, together with blood lymphocyte count and irradiation side-effects, over a mean follow-up period of 20.8 months (range: 13-24). Our findings indicate that: a) disease progression was not markedly reduced by TLI; b) steroid hormones responsivity was restored after irradiation, and c) side-effects were mild and tolerable

  13. Portable multiplicity counter

    Science.gov (United States)

    Newell, Matthew R [Los Alamos, NM; Jones, David Carl [Los Alamos, NM

    2009-09-01

    A portable multiplicity counter has signal input circuitry, processing circuitry and a user/computer interface disposed in a housing. The processing circuitry, which can comprise a microcontroller integrated circuit operably coupled to shift register circuitry implemented in a field programmable gate array, is configured to be operable via the user/computer interface to count input signal pluses receivable at said signal input circuitry and record time correlations thereof in a total counting mode, coincidence counting mode and/or a multiplicity counting mode. The user/computer interface can be for example an LCD display/keypad and/or a USB interface. The counter can include a battery pack for powering the counter and low/high voltage power supplies for biasing external detectors so that the counter can be configured as a hand-held device for counting neutron events.

  14. Suicide and multiple sclerosis

    DEFF Research Database (Denmark)

    Stenager, E N; Stenager, Egon; Koch-Henriksen, Nils

    1992-01-01

    In a nationwide investigation the risk of death by suicide for patients with multiple sclerosis (MS) was assessed using records kept at the Danish Multiple Sclerosis Registry (DMSR) and the Danish National Register of Cause of Death. The investigation covers all MS patients registered with DSMR...... with an onset of the disease within the period 1953-85, or for whom MS was diagnosed in the same period. Fifty three of the 5525 cases in the onset cohort group committed suicide. Using the figures from the population death statistics by adjustment to number of subjects, duration of observation, sex, age......, and calendar year at the start of observation, the expected number of suicides was calculated to be nearly 29. The cumulative lifetime risk of suicide from onset of MS, using an actuarial method of calculation, was 1.95%. The standard mortality ratio (SMR) of suicide in MS was 1.83. It was highest for males...

  15. Curability of Multiple Myeloma

    Directory of Open Access Journals (Sweden)

    Raymond Alexanian

    2012-01-01

    Full Text Available Among 792 patients with multiple myeloma treated from 1987 to 2010 and assessed after 18 months, there were 167 patients with complete remission. For those 60 patients treated between 1987–1998 and with long followup, the latest relapse occurred after 11.8 years, so that 13 patients have remained in sustained complete remission for longer than 12 years (range 12–22 years. These results suggest that 3% of all patients treated during that period may be cured of multiple myeloma. In addition to immunofixation, more sensitive techniques for the detection of residual disease should be applied more consistently in patients with apparent complete remission in order to identify those with potential cure.

  16. Multiple time scale dynamics

    CERN Document Server

    Kuehn, Christian

    2015-01-01

    This book provides an introduction to dynamical systems with multiple time scales. The approach it takes is to provide an overview of key areas, particularly topics that are less available in the introductory form.  The broad range of topics included makes it accessible for students and researchers new to the field to gain a quick and thorough overview. The first of its kind, this book merges a wide variety of different mathematical techniques into a more unified framework. The book is highly illustrated with many examples and exercises and an extensive bibliography. The target audience of this  book are senior undergraduates, graduate students as well as researchers interested in using the multiple time scale dynamics theory in nonlinear science, either from a theoretical or a mathematical modeling perspective. 

  17. Core Multiplication in Childhood

    Science.gov (United States)

    McCrink, Koleen; Spelke, Elizabeth S.

    2011-01-01

    A dedicated, non-symbolic, system yielding imprecise representations of large quantities (Approximate Number System, or ANS) has been shown to support arithmetic calculations of addition and subtraction. In the present study, 5–7-year-old children without formal schooling in multiplication and division were given a task requiring a scalar transformation of large approximate numerosities, presented as arrays of objects. In different conditions, the required calculation was doubling, quadrupling, or increasing by a fractional factor (2.5). In all conditions, participants were able to represent the outcome of the transformation at above-chance levels, even on the earliest training trials. Their performance could not be explained by processes of repeated addition, and it showed the critical ratio signature of the ANS. These findings provide evidence for an untrained, intuitive process of calculating multiplicative numerical relationships, providing a further foundation for formal arithmetic instruction. PMID:20537618

  18. Subcritical multiplication determination studies

    Energy Technology Data Exchange (ETDEWEB)

    Estes, G.P.; Goulding, C.A.

    1995-07-01

    A series of measurements and improvements to computational techniques are in progress at Los Alamos National Laboratory that are aimed at better understanding the determination of the reactivity of subcritical systems from measurements of the apparent multiplication of the system. Such studies are being performed in order to improve the special nuclear material (SNM) assays of unknown systems such as those encountered in SNM safeguards, arms-control verification, imports of foreign-generated SNM, etc. Improved techniques and understanding are needed since measured multiplication is not always an invariant characteristic of a subcritical system, especially if one has a system with no significant intrinsic internal neutron source that is illuminated nonuniformly with an external source (i.e., a non-normal mode system).

  19. Lipedema with multiple lipomas.

    Science.gov (United States)

    Pascucci, Anabella; Lynch, Peter J

    2010-09-15

    Lipedema is an underdiagnosed syndrome of unclear etiology, characterized by symmetric painful enlargement of the buttocks and lower extremities, which spares the feet. This enlargement is caused by the deposition of adipose tissue. It was first described by Allen and Hines in 1940, who observed that it had a female predilection; patients commonly had an associated family history. We describe a patient with classic lipedema and multiple lipomas of her arms and trunk.

  20. Les tables de multiplication

    OpenAIRE

    Ghys, Etienne

    2009-01-01

    International audience; Ah ! les tables de multiplication de notre enfance, quels mauvais souvenirs ! (en ce qui me concerne, c'est la table de 7 qui m'a posé des problèmes). Elles nous narguaient sur le dos des cahiers de brouillon... Y aurait-il encore aujourd'hui des mathématiciens qui tenteraient d'en simplifier l'usage ?

  1. Multiple lymphatic cervical cysts

    International Nuclear Information System (INIS)

    Jordan, J.; Piotrowski, S.; Zalewska-Rzezniczak, I.

    1994-01-01

    Authors described a case of 60 year-old woman with multiple lateral neck cysts. 4 cysts were located in the supraclavicular region of lateral neck triangle. During histopathological studies of postoperative specimens a cystic hygroma diagnosis was established. The fact, that cystic lymphangioma occurred in an adult woman, was interesting. The authors stress the necessity of preoperative evaluation of tumor size in view of the possibility of its penetration into the thorax. The CT examination may be useful in these cases. (author)

  2. Summarizing multiple deprivation indicators

    OpenAIRE

    Cappellari, Lorenzo; Jenkins, Stephen P.

    2006-01-01

    Deprivation scales derived from multiple, typically dichotomous, indicators, are widely used to monitor households’ standards of living, and to complement measures of living standards based on income. We use an item response modelling (IRM) framework to address several issues concerning the derivation of deprivation scales in general and the use of sum-score deprivation indices in particular. Although we favour the IRM approach over the sum-score one in principle, we find in an illustrative...

  3. Cognition in multiple sclerosis

    OpenAIRE

    Sumowski, James F.; Benedict, Ralph; Enzinger, Christian; Filippi, Massimo; Geurts, Jeroen J.; Hamalainen, Paivi; Hulst, Hanneke; Inglese, Matilde; Leavitt, Victoria M.; Rocca, Maria A.; Rosti-Otajarvi, Eija M.; Rao, Stephen

    2018-01-01

    Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporate cognitive assessment into standard clinical care and clinical trials, (2) utilize state-of-the-art neuroimaging to more thoroughly understand neural bases of cognitive deficits, and (3) develop effective, evidence-based, clinically feasible interventions to prevent or treat cognitive dysfunction, whic...

  4. Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.

    Directory of Open Access Journals (Sweden)

    Motoi Suzuki

    Full Text Available The objective of this study was to estimate influenza vaccine effectiveness (VE against medically attended, laboratory-confirmed influenza during the 2011-2012 season in Japan using a test-negative case-control study design. The effect of co-circulating non-influenza respiratory viruses (NIRVs on VE estimates was also explored. Nasopharyngeal swab samples were collected from outpatients with influenza-like illnesses (ILIs in a community hospital in Nagasaki, Japan. Thirteen respiratory viruses (RVs, including influenza A and B, were identified from the samples using a multiplex polymerase chain reaction. The difference in VE point estimates was assessed using three different controls: ILI patients that tested negative for influenza, those that tested negative for all RVs, and those that tested positive for NIRVs. The adjusted VE against medically attended, laboratory-confirmed influenza using all influenza-negative controls was 5.3% (95% confidence interval [CI], -60.5 to 44.1. The adjusted VEs using RV-negative and NIRV-positive controls were -1.5% (95% CI, -74.7 to 41 and 50% (95% CI, -43.2 to 82.5, respectively. Influenza VE was limited in Japan during the 2011-2012 season. Although the evidence is not conclusive, co-circulating NIRVs may affect influenza VE estimates in test-negative case-control studies.

  5. Acute hemorrhagic leukoencephalitis with severe brainstem and spinal cord involvement: MRI features with neuropathological confirmation.

    Science.gov (United States)

    Pinto, Pedro S; Taipa, Ricardo; Moreira, Bruno; Correia, Carlos; Melo-Pires, Manuel

    2011-04-01

    Acute hemorrhagic leukoencephalitis (AHLE) is a rare and fulminant demyelinating disease considered to be the most severe form of acute disseminated encephalomyelitis (ADEM). A 70-year-old man was admitted to our emergency department (ED) after 1 week of unspecific abdominal symptoms and moderate fever in the first 3 days. Within the ED he developed a rapid onset coma and flaccid tetraparesis. Cerebrospinal fluid (CSF) analysis showed mild polymorphonuclear pleocytosis and magnetic resonance imaging (MRI) revealed supratentorial focal white matter lesions and diffuse involvement of the medulla and spinal cord. A presumptive diagnosis of ADEM was made and the patient was treated with corticosteroids followed by intravenous immunoglobulin. His neurological state did not improve and the MRI on day 8 after admission showed an increased number of lesions, mainly in the brainstem, with hemorrhagic foci. The patient died the following day and pathological features confirmed the diagnosis of AHLE. This is a unique presentation of a rare disease with detailed MRI characteristics and pathological confirmation. Although this condition is usually fatal, early recognition and aggressive therapeutic management can facilitate survival. Copyright © 2011 Wiley-Liss, Inc.

  6. Individual serological follow-up of patients with suspected or confirmed abdominal angiostrongyliasis

    Directory of Open Access Journals (Sweden)

    Penélope E Palominos

    2008-02-01

    Full Text Available Abdominal angiostrongyliasis (AA is a zoonotic nematode infection caused by Angiostrongylus costaricensis, with widespread occurrence in the Americas. Although the human infection may be highly prevalent, morbidity is low in Southern Brazil. Confirmed diagnosis is based on finding parasitic structures in pathological examination of biopsies or surgical resections. Serology stands as an important diagnostic tool in the less severe courses of the infection. Our objective is to describe the follow up of humoral reactivity every 2-4 weeks up to one year, in six individuals with confirmed (C and ten suspected (S AA. Antibody (IgG detection was performed by ELISA and resulted in gradually declining curves of reactivity in nine subjects (56% (4C + 5S, that were consistently negative in only three of them (2C + 1S after 221, 121 and 298 days. Three individuals (2C + 1S presented with low persistent reacitivity, other two (1C + 1S were serologically negative from the beginning, but also presenting a declining tendency. The study shows indications that abdominal angiostrongyliasis is usually not a persistent infection: although serological negativation may take many months, IgG reactivity is usually declining along time and serum samples pairing may add valuable information to the diagnostic workout.

  7. Laboratory confirmation of measles in elimination settings: experience from the Republic of the Marshall Islands, 2003.

    Science.gov (United States)

    Hyde, Terri B; Nandy, Robin; Hickman, Carole J; Langidrik, Justina R; Strebel, Peter M; Papania, Mark J; Seward, Jane F; Bellini, William J

    2009-02-01

    To highlight the complications involved in interpreting laboratory tests of measles immunoglobulin M (IgM) for confirmation of infection during a measles outbreak in a highly vaccinated population after conducting a mass immunization campaign as a control measure. This case study was undertaken in the Republic of the Marshall Islands during a measles outbreak in 2003, when response immunization was conducted. A measles case was defined as fever and rash and one or more of cough, coryza or conjunctivitis. Between 13 July and 7 November 2003, serum samples were obtained from suspected measles cases for serologic testing and nasopharyngeal swabs were taken for viral isolation by reverse transcriptase polymerase chain reaction (RT-PCR). Specimens were collected from 201 suspected measles cases (19% of total): of the ones that satisfied the clinical case definition, 45% were IgM positive (IgM+) and, of these, 24% had received measles vaccination within the previous 45 days (up to 45 days after vaccination an IgM+ result could be due to either vaccination or wild-type measles infection). The proportion of IgM+ results varied with clinical presentation, the timing of specimen collection and vaccination status. Positive results on RT-PCR occurred in specimens from eight IgM-negative and four IgM+ individuals who had recently been vaccinated. During measles outbreaks, limiting IgM testing to individuals who meet the clinical case definition and have not been recently vaccinated allows for measles to be confirmed while conserving resources.

  8. Confirmed Ceylon krait (Bungarus ceylonicus) envenoming in Sri Lanka resulting in neuromuscular paralysis: a case report.

    Science.gov (United States)

    Dalugama, Chamara; Gawarammana, Indika Bandara

    2017-11-24

    Ceylon krait (Bungarus ceylonicus) is a venomous elapid snake endemic to Sri Lanka. It inhabits shaded home gardens and forests in the wet zone of Sri Lanka and might creep into houses in the night. Despite frequent encounters with humans, reports of envenoming are very rare. We report a case of a 26-year-old Sri Lankan Sinhalese man with confirmed Ceylon krait envenoming presenting with bilateral partial ptosis, ophthalmoplegia, facial muscle weakness, and dysphagia. Single fiber electromyography and repetitive nerve stimulation confirmed neuromuscular paralysis. He was administered polyvalent anti-venom serum immediately following admission without a prompt clinical response. Complete recovery was observed 3 days following the bite. Because of the rarity of envenoming, precise and detailed information on the clinical manifestations following envenoming is lacking. However, Ceylon krait bite can be potentially fatal; so, treating physicians should be aware of species identification, habitat, and biting habits and clinical presentation of envenoming of Ceylon krait. This case report adds knowledge to the existing limited literature available on Ceylon krait envenoming; a rare but potentially fatal clinical entity.

  9. Transport and Management of Patients With Confirmed or Suspected Ebola Virus Disease.

    Science.gov (United States)

    Isakov, Alexander; Miles, Wade; Gibbs, Shawn; Lowe, John; Jamison, Aaron; Swansiger, Raymond

    2015-09-01

    The foundation of safe care for patients with confirmed or suspected Ebola virus disease is effective infection control practice, which requires implementation of appropriate administrative policies, work practices, and environmental controls, accompanied by focused education, training, and supervision. In 2002, Emory University partnered with the Centers for Disease Control and Prevention to develop a capability for the evaluation and management of individuals with serious communicable disease. In 2005, the University of Nebraska developed a similar isolation capability. In each case, the hospitals partnered with emergency medical services (EMS) professionals to ensure safe out-of-hospital transport and management of their patients. The objectives of these hospital and out-of-hospital collaborations were to close education, training, and practice gaps to best facilitate the care for patients with serious communicable disease while ensuring the safety of the medics and the general public through meticulous implementation of infection control practices as recommended by Centers for Disease Control and Prevention. The description of practices implemented by EMS teams in these communities for the transport of patients with confirmed Ebola virus disease is shared so that others might more readily implement these practices, policies, and procedures as applicable to their mission requirements and system design. Transport of patients with relevant travel history and development of illness (persons under investigation) is also included. Copyright © 2015 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

  10. Performance Confirmation for the Engineered Barrier System. Report of a Workshop

    International Nuclear Information System (INIS)

    Bennett, David G.

    2004-08-01

    As part of preparations for review of future license applications, the Swedish Nuclear Power Inspectorate (SKI) organised a workshop on the engineered barrier system for the KBS-3 concept, focused on Performance Confirmation (PC). The workshop was held during 12 - 14 May, 2004 at Oskarshamn. The main purpose of the workshop was to identify key issues relating to the demonstration of long-term safety using a system of engineered barriers. The workshop began with introductory presentations on Performance Confirmation, on monitoring, and on long-term experiments in underground research laboratories. Working groups were then convened to discuss these topics and identify questions to put to the Swedish Nuclear Fuel and Waste Management Company (SKB) the following day. On the second day, SKB made several presentations, mainly on long-term experiments conducted at the Aespoe underground research laboratory. These presentations were followed by an informal session during which the questions identified by the working groups on the first day were discussed with SKB and its representatives. This report includes the questions identified by the working groups and a summary of the workshop discussions. Extended abstracts for the introductory presentations are included in an appendix. The conclusions and viewpoints presented in this report are those of one or several workshop participants. They do not necessarily coincide with those of SKI

  11. Measurement of bio-impedance with a smart needle to confirm percutaneous kidney access.

    Science.gov (United States)

    Hernandez, D J; Sinkov, V A; Roberts, W W; Allaf, M E; Patriciu, A; Jarrett, T W; Kavoussi, L R; Stoianovici, D

    2001-10-01

    The traditional method of percutaneous renal access requires freehand needle placement guided by C-arm fluoroscopy, ultrasonography, or computerized tomography. This approach provides limited objective means for verifying successful access. We developed an impedance based percutaneous Smart Needle system and successfully used it to confirm collecting system access in ex vivo porcine kidneys. The Smart Needle consists of a modified 18 gauge percutaneous access needle with the inner stylet electrically insulated from the outer sheath. Impedance is measured between the exposed stylet tip and sheath using Model 4275 LCR meter (Hewlett-Packard, Sunnyvale, California). An ex vivo porcine kidney was distended by continuous gravity infusion of 100 cm. water saline from a catheter passed through the parenchyma into the collecting system. The Smart Needle was gradually inserted into the kidney to measure depth precisely using a robotic needle placement system, while impedance was measured continuously. The Smart Needle was inserted 4 times in each of 4 kidneys. When the needle penetrated the distended collecting system in 11 of 16 attempts, a characteristic sharp drop in resistivity was noted from 1.9 to 1.1 ohm m. Entry into the collecting system was confirmed by removing the stylet and observing fluid flow from the sheath. This characteristic impedance change was observed only at successful entry into the collecting system. A characteristic sharp drop in impedance signifies successful entry into the collecting system. The Smart Needle system may prove useful for percutaneous kidney access.

  12. Endometriosis-associated hydrocele of the canal of Nuck with immunohistochemical confirmation: a case report.

    Science.gov (United States)

    Okoshi, Kae; Mizumoto, Masaki; Kinoshita, Koichi

    2017-12-21

    The canal of Nuck is an embryological vestige of the processus vaginalis, and presents a potential site for endometriosis seeding. Hydroceles in this region are a rare cause of inguinal swelling in females. In addition, endometriosis localized to the canal of Nuck is exceedingly rare. A 44-year-old Japanese woman presented with a painful mass overlying her right pubis. She underwent surgery to completely excise the mass. During surgery, division of the external oblique aponeurosis revealed a cyst that occupied the inguinal canal and it adhered to the transverse fascia, inguinal ligament, and pubic bone. The cyst was dissected from the round ligament, and the defect in the internal inguinal ring was repaired and reinforced with mesh. On macroscopic examination, the cyst had a heterogeneous fibrous aspect with dark brown inclusions. Microscopic examination revealed that the cyst was tortuous, lined by mesothelial-like cells, and accompanied by partial subcapsular hemorrhage. Endometrium-like tissue was observed in the cystic wall. Immunohistochemical staining for podoplanin confirmed the mesothelial origin of the cyst-lining cells. The epithelial cells and stromal cells were positive for estrogen receptors. In this case of an endometriosis-associated hydrocele of the canal of Nuck, the mesothelial origin of the cyst-lining cells and endometriosis were confirmed by positive immunohistochemical staining for podoplanin and estrogen receptors, respectively. We determined that hydrocele resection and reinforcement of the anterior inguinal canal wall (if necessary) are appropriate treatments for this condition.

  13. The New Zealand Neuromuscular Disease Registry: rate of diagnoses confirmed by molecular testing.

    Science.gov (United States)

    Rodrigues, Miriam; Kidd, Alexa; Love, Donald R; Roxburgh, Richard

    2015-02-01

    The New Zealand Neuromuscular Disease Registry (NZ NMD Registry) is part of the TREAT NMD Alliance, an international network that provides infrastructure ensuring the most promising new therapies reach neuromuscular patients as quickly as possible. Its main aim is to ensure that the most promising new therapies reach patients as quickly as possible. From the perspective of researchers interested in trialling treatments it is useful to have data on the pool of potential research participants. From a patient's perspective it is important to know what trials they can take part in. Both of these require a confirmed molecular diagnosis in the patient. Some therapeutic strategies not only require knowledge of which gene is affected but are targeted at specific mutations within the gene. In reviewing data held in the NZ NMD Registry it was noted that, of those diagnosed with a genetic condition, only 51% have a confirmed molecular genetic diagnosis. This low rate of genetic diagnosis is a potential barrier to research participation but can be removed with improved genetic technology and with changes in knowledge about and attitudes towards genetic testing. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Recognizing true H5N1 infections in humans during confirmed outbreaks.

    Science.gov (United States)

    Zaman, Mukhtiar; Gasimov, Viktor; Oner, Ahmet Faik; Dogan, Nazim; Adisasmito, Wiku; Coker, Richard; Bamgboye, Ebun L; Chan, Paul K S; Hanshaoworakul, Wanna; Lee, Nelson; Phommasack, Bounlay; Touch, Sok; Tsang, Owen; Swenson, Anna; Toovey, Stephen; Dreyer, Nancy Ann

    2014-02-13

    The goal of this study was to evaluate whether any characteristics that are evident at presentation for urgent medical attention could be used to differentiate cases of H5N1 in the absence of viral testing. Information about exposure to poultry, clinical signs and symptoms, treatments, and outcomes was abstracted from existing data in the global avian influenza registry (www.avianfluregistry.org) using standardized data collection tools for documented and possible cases of H5N1 infection who presented for medical attention between 2005-2011 during known H5N1 outbreaks in Azerbaijan, Indonesia, Pakistan and Turkey. Demography, exposure to poultry, and presenting symptoms were compared, with only the common symptoms of fever and headache presenting significantly more frequently in confirmed H5N1 cases than in possible cases. Reported exposure to  infected humans was also more common in confirmed cases. In contrast, unexplained respiratory illness, sore throat, excess sputum production, and rhinorrhea were more frequent in possible cases. Overall, oseltamivir treatment showed a survival benefit, with the greatest benefit shown in H5N1 cases who were treated within two days of symptom onset (51% reduction in case fatality). Since prompt treatment with antivirals conferred a strong survival benefit for H5N1 cases, presumptive antiviral treatment should be considered for all possible cases presenting during an outbreak of H5N1 as a potentially life-saving measure.

  15. Confirmation of protoplast fusion-derived linkages in Staphylococcus aureus by transformation with protoplast DNA.

    Science.gov (United States)

    Stahl, M L; Pattee, P A

    1983-01-01

    Transformation provided definitive evidence for linkage between tyrB282::Tn551 ermB321 and omega (Chr::Tn551)34, and thus between the separate large linkage groups containing these markers, in Staphylococcus aureus NCTC 8325. Transformation also defined the chromosomal loci for the purC193::Tn551 and omega (Chr::Tn551)42 markers and the linkage of a tetracycline resistance marker (tet-3490) with a fusidic acid resistance marker (fus-149). The use of DNA isolated from protoplasts under conditions that reduced hydrodynamic shear greatly facilitated the demonstration of most of these linkages. These results provide direct evidence confirming several of the linkages predicted by a microcomputer-assisted protoplast fusion analysis in a previous study (M. L. Stahl and P. A. Pattee, J. Bacteriol. 154:395-405, 1983); those markers whose predicted linkages were not confirmed by transformation are probably separated by chromosomal distances that exceed the limits of detection by transformation, even with protoplast DNA. PMID:6572625

  16. Confirming competence of operators - A regulatory approach to fuel cycle facilities

    International Nuclear Information System (INIS)

    Vesely, M.; Sigetich, J.

    2013-01-01

    For the past 40 years the Canadian Nuclear Safety Commission (CNSC), formerly the Atomic Energy Control Board, has certified workers in nuclear facilities. The requirement for certified personnel has ensured that workers assigned to positions that have a direct impact on the safe operation of the facility are fully qualified to perform their duties. This certification regime is defined in the regulatory framework under which the CNSC operates. Traditionally, this certification regime has been applied to Reactor Operators, Shift Supervisors and Health Physicists in Nuclear Power Plants and research reactors as well as to Exposure Device Operators who use nuclear substances for the purposes of industrial radiography. Stemming from progress made in implementing risk-informed regulatory oversight activities as well as a formal suggestion from the International Atomic Energy Agency - International Regulatory Review Service (IRRS) conducted on the CNSC in 2009, a regulatory approach to confirming the competence of Operators at Fuel Cycle Facilities has been initiated by CNSC staff. In the first stage of the implementation of this new regulatory approach, the CNSC had Cameco Corporation implement a formal internal qualification programme for the UF6 Operators at its Port Hope Conversion Facility (PHCF) in Port Hope, Ontario. In the future, following a review of the results of the qualification programme at the PHCF, the CNSC staff will evaluate the need for the application of a similar regulatory approach to confirm the competence of the Operators at other Fuel Cycle Facilities in Canada. (authors)

  17. Confirmation of the structure of lipid A from Enterobacter agglomerans by electrospray ionization tandem mass spectrometry

    Science.gov (United States)

    Boue; Cole

    2000-03-01

    Electrospray ionization (ESI) combined with tandem mass spectrometry (MS/MS) was utilized for the structural confirmation of lipid A derived from Enterobacter agglomerans, a Gram-negative bacterium commonly found in field cotton. Previous ESI-MS studies conducted in our laboratory found that similarities exist between the fatty acid side-chains in the lipid A of E. agglomerans and that of Salmonella minnesota. It was noted that heterogeneity at the fatty acyl chain at position 3' of the diglucosamine backbone of E. agglomerans can take the form of either a myristyloxymyristyl group or, less commonly, a hydroxymyristyloxymyristyl moiety. In this work, tandem mass spectra obtained from heptaacyl and hexaacyl lipid A precursors derived from E. agglomerans and a known standard S. minnesota were compared to assist in structural elucidation. These ESI-MS/MS experiments confirmed the previously reported structure for lipid A derived from E. agglomerans. Moreover, MS/MS data indicated that the additional hydroxyl group of the 3'-position hydroxymyristyloxymyristyl moiety is present as the alpha-isomer.

  18. Bifid mandibular canal: confirmation of limited cone beam CT findings by gross anatomical and histological investigations

    Science.gov (United States)

    Fukami, K; Shiozaki, K; Mishima, A; Kuribayashi, A; Hamada, Y; Kobayashi, K

    2012-01-01

    Objectives The aims of this study were (1) to assess the validity of limited cone beam CT (CBCT) in detecting the distribution of bifid mandibular canals in the retromolar region by comparing its findings with those of panoramic radiography and spiral CT imaging, and (2) to confirm the contents of such canals depicted on limited CBCT images by using gross anatomical and histological methods. Methods Bilateral bifid mandibular canals of a Japanese cadaver were investigated. The canals depicted on panoramic radiography, spiral CT and limited CBCT images were compared. Cross-sectional limited CBCT images of these canals were compared with gross anatomical sections of the mandible and their contents were confirmed histologically. Results The spiral CT and limited CBCT images showed the bilateral bifid mandibular canals in the retromolar region whereas the panoramic radiographs indicated the presence of only the left bifid mandibular canal. The canal distribution was more distinct in the limited CBCT images than in the spiral CT images and the cross-sectional limited CBCT images were consistent with the gross anatomical sections. Histologically, the canals contained several nerve bundles and arteries among which the largest nerve and artery were of a similar size. Conclusion Limited CBCT is valuable for assessing the distribution of bifid mandibular canals. It is clinically significant to accurately localize a bifid mandibular canal of the retromolar region because it contains a nerve bundle and artery. PMID:22116121

  19. An autopsy-confirmed case of progressive supranuclear palsy with predominant postural instability.

    Science.gov (United States)

    Kurz, Carolin; Ebersbach, Georg; Respondek, Gesine; Giese, Armin; Arzberger, Thomas; Höglinger, Günter Ulrich

    2016-11-14

    Postural instability and supranuclear gaze palsy represent the key symptoms of Richardson's syndrome, the most frequent clinical manifestation of progressive supranuclear palsy (PSP). However, a proportion of PSP patients never develops ocular motor symptoms, which prevents clinicians from establishing the diagnosis during lifetime according to current diagnostic criteria. We present one instructive autopsy-confirmed PSP case with prospective video-documented clinical course, showing striking temporal divergence of initially present postural instability and delayed development of ocular motor dysfunction. Brain imaging and autopsy findings were typical of PSP, but the temporal sequence of symptoms was unusual with isolated postural instability predominating the clinical course for many years and slowing of vertical saccades/supranuclear gaze palsy evolving not until the 9 th /11 th year after disease onset. Although other differential diagnoses were unlikely, this patient did not pass the threshold for possible or probable diagnosis of PSP according to current diagnostic criteria until very late in the disease course. This first well documented, autopsy confirmed case of PSP with predominant postural instability further expands the clinical spectrum of PSP and points out the need of new clinical diagnostic criteria with sufficient sensitivity and specificity for an early and reliable diagnosis.

  20. Axillary nerve palsy after retrograde humeral nailing: clinical confirmation of an anatomical fear.

    Science.gov (United States)

    Lögters, Tim Tobias; Wild, Michael; Windolf, Joachim; Linhart, Wolfgang

    2008-12-01

    Locked antegrade or retrograde nailing of humeral shaft and proximal humerus fractures is a well established treatment option. Anatomic-morphological studies revealed a potential high risk of axillary nerve injury within proximal interlocking screw insertion. However, clinical experiences do not seem to confirm this, as there is a lack of interlocking screw insertion associated axillary lesions in literature. We report about a 69-year-old man with a humeral shaft fracture (AO-type 12-A3) stabilized by a retrograde implanted interlocking nail. Proximal interlocking screw insertion was performed in a posterior-to-anterior direction. The fracture healed uneventfully. In a follow-up examination 2 years later, an atrophy and paralysis of the deltoid muscle were visible. Electrophysiological evaluation confirmed an isolated axillary nerve injury. Nevertheless, the patient showed good functional recovery with almost free range of motion. Even for clinical practise proximal interlocking screw insertion is associated with a substantial risk of axillary nerve injury. Particularly for posterior-to-anterior screw insertion anatomic conditions should be considered. In spite of axillary nerve lesion, recovery of almost full shoulder function is possible by compensating the loss of deltoid function by rotator cuff muscles.

  1. Small breed dogs with confirmed stroke: concurrent diseases and sonographic findings

    Directory of Open Access Journals (Sweden)

    C.F. Carvalho

    2012-10-01

    Full Text Available Cerebrovascular accidents (CVA are important causes of neurological clinical signs in dogs. The objective of this work was to describe concurrent diseases and ultrasonographic features in dogs with CVA confirmed through postmortem evaluation. All medical records of transcranial Doppler ultrasonography (TCDUS examinations performed in 512 dogs between 2007 and 2009 were reviewed, searching for history and clinical diagnosis, as well as sonographic and histological results. Forty-two dogs were selected, showing acute onset of clinical signs with no progressive focal cerebral dysfunction and diagnosis of cerebrovascular disease confirmed at necropsy. Concurrent diseases and conditions were: cerebral amyloid microangiopathy (33%, endocrinopathies (31%, coagulopathy (24%, Schnauzer hyperlipemia (7% and unknown (5%. The relation between sonography and histology results indicated 100% sensitivity and 90% specificity for focal lesion detection. A diffuse decrease in echogenicity was related to inflammatory diseases and/or edema with 62% sensitivity. A diffuse increase in echogenicity has 100% sensitivity and was usually related to aging changes. This study showed the occurrence of coexisting diseases with CVA and sonographic features of these conditions in small breed dogs.

  2. An alternative method for screening lactic acid bacteria for the production of exopolysaccharides with rapid confirmation

    Directory of Open Access Journals (Sweden)

    Elinalva Maciel Paulo

    2012-12-01

    Full Text Available The accumulation of exopolysaccharides (EPS produced by microorganisms occurs in the presence of excess substrate and limiting conditions of elements that are essential to growth, such as nitrogen, phosphorus, sulfur, and magnesium. The presence of EPS produced by bacterial cells contributes to slime colonies formation in solid medium and increased viscosity in liquid medium. This paper proposes an alternative method for screening EPS-producing lactic acid bacteria using solid medium-containing discs of filter paper that are saturated with active cultures. The screening was carried out under different culture conditions varying the type of sugar, pH, and temperature. EPS production was visualized by the presence of mucoid colonies on the discs, which was confirmed by the formation of a precipitate when part of this colony was mixed with absolute alcohol. The established conditions for obtaining a high number of isolates producing EPS were 10% sucrose, pH 7.5 and 28 ºC. This method proved to be effective and economical because several strains could be tested on the same plate, with immediate confirmation.

  3. Ubiquitous healthy diatoms in the deep sea confirm deep carbon injection by the biological pump

    KAUST Repository

    Agusti, Susana

    2015-07-09

    The role of the ocean as a sink for CO2 is partially dependent on the downward transport of phytoplankton cells packaged within fast-sinking particles. However, whether such fast-sinking mechanisms deliver fresh organic carbon down to the deep bathypelagic sea and whether this mechanism is prevalent across the ocean requires confirmation. Here we report the ubiquitous presence of healthy photosynthetic cells, dominated by diatoms, down to 4,000 m in the deep dark ocean. Decay experiments with surface phytoplankton suggested that the large proportion (18%) of healthy photosynthetic cells observed, on average, in the dark ocean, requires transport times from a few days to a few weeks, corresponding to sinking rates (124–732 m d−1) comparable to those of fast-sinking aggregates and faecal pellets. These results confirm the expectation that fast-sinking mechanisms inject fresh organic carbon into the deep sea and that this is a prevalent process operating across the global oligotrophic ocean.

  4. Design stage confirmation of lifetime improvement for newly modified products through accelerated life testing

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadian, S. Hossein, E-mail: seyed-h.mohammadian.1@ulaval.c [Centre Interuniversitaire de Recherche sur les Reseaux d' Entreprise, la Logistique et le Transport (CIRRELT), Departement de Genie Mecanique, Pavillon Adrien-Pouliot, Universite Laval, Quebec, G1V 0A6 (Canada) and Centre Interdisciplinaire de Recherche en Readaptation et en Integration Sociale (CIRRIS), Institut de Readaptation en Deficience Physique de Quebec, 525 Boul. Hamel, Quebec, G1M 2S8 (Canada); Ait-Kadi, Daoud, E-mail: Daoud.Aitkadi@gmc.ulaval.c [Centre Interuniversitaire de Recherche sur les Reseaux d' Entreprise, la Logistique et le Transport (CIRRELT), Departement de Genie Mecanique, Pavillon Adrien-Pouliot, Universite Laval, Quebec, G1V 0A6 (Canada); Centre Interdisciplinaire de Recherche en Readaptation et en Integration Sociale (CIRRIS), Institut de Readaptation en Deficience Physique de Quebec, 525 Boul. Hamel, Quebec, G1M 2S8 (Canada)

    2010-08-15

    After a modification to the original version of a product and before mass production, the expected improvement in the product lifetime or reliability needs to be validated. This paper presents three approaches based on accelerated life testing to verify, estimate and confirm the lifetime or reliability of a newly modified product at design stage: ALT comparative approach, reliability estimation approach, and reliability validation test. Test samples of the original and modified versions are expected to fail during the tests in order to obtain their failure time data. In ALT comparative approach, the statistical comparison between failure time data of the original and modified versions is used to verify the required improvement in lifetime. In reliability estimation approach, the relationship made between available lifetime and failure time data of the original version is used to extrapolate lifetime data of the modified version from its failure time data. Since modified versions are usually highly reliable, all test samples might survive the tests (without any failures) that results in the lack of failure time data for statistical analysis. To confirm a level of service reliability with confidence, reliability validation test is presented to make an estimate of the number of samples required to survive the tests. To fulfill the same level of confidence for fewer number of prototypes (as test samples), the test time must be extended. On the other hand, more prototypes are needed to pass a shorter test time if there are any time constraints.

  5. Reappraising hyalinizing clear cell carcinoma: A population-based study with molecular confirmation.

    Science.gov (United States)

    Hernandez-Prera, Juan C; Kwan, Ricky; Tripodi, Joseph; Chiosea, Simion; Cordon-Cardo, Carlos; Najfeld, Vesna; Demicco, Elizabeth G

    2017-03-01

    Hyalinizing clear cell carcinoma (HCCC) is a rare malignancy, characterized by EWSR1-ATF1 gene fusion, whose behavior is poorly understood, as it was for many years considered a diagnosis of exclusion. All available salivary gland carcinomas (n = 594) from our institution were reviewed. Diagnosis of HCCC was confirmed by fluorescence in situ hybridization (FISH) for EWSR1. Literature review was performed. We found 15 patients with HCCCs (10 women, 5 men), 13 with EWSR1 rearrangement. Median age at diagnosis was 57 years (range, 31-87 years). Oral cavity (n = 9) and base of tongue (n = 4) were the most frequent primary sites. Combining our cases with those identified in literature review, the 10-year risk of local recurrence and locoregional nodal metastasis were 49% and 15%, respectively. Molecularly confirmed HCCC accounted for 2.5% of salivary gland malignancies at our institution. HCCCs are indolent tumors with a propensity for locoregional recurrence. © 2016 Wiley Periodicals, Inc. Head Neck 39: 503-511, 2017. © 2016 Wiley Periodicals, Inc.

  6. Two new confirmed massive relic galaxies: red nuggets in the present-day Universe

    Science.gov (United States)

    Ferré-Mateu, Anna; Trujillo, Ignacio; Martín-Navarro, Ignacio; Vazdekis, Alexandre; Mezcua, Mar; Balcells, Marc; Domínguez, Lilian

    2017-05-01

    We confirm two new local massive relic galaxies, I.e. untouched survivors of the early Universe massive population: Mrk 1216 and PGC 032873. Both show early and peaked formation events within very short time-scales (histories remain virtually unchanged out to several effective radii, even when considering the steeper initial-mass-function values inferred out to ˜3 effective radii. Their morphologies, kinematics and density profiles are like those found in the z > 2 massive population, setting them apart from the typical z ˜ 0 massive early-type galaxies. We find that there seems to exist a degree of relic that is related to how far into the path, to become one of these typical z ˜ 0 massive galaxies, the compact relic has moved. This path is partly dictated by the environment the galaxy lives in. For galaxies in rich environments, such as the previously reported relic galaxy NGC 1277, the most extreme properties (e.g. sizes, short formation time-scales, larger supermassive black holes) are expected, while lower density environments will have galaxies with delayed and/or extended star formations, slightly larger sizes and not that extreme black hole masses. The confirmation of three relic galaxies up to a distance of 106 Mpc, implies a lower limit in the number density of these red nuggets in the local Universe of 6 × 10-7 Mpc3, which is within the theoretical expectations.

  7. Effective appropriate use of dental remains and forensic DNA testing for personal identity confirmation.

    Science.gov (United States)

    Ohira, Hiroshi; Yamamuro, Yoshio; Kitagawa, Yuka; Nakagawa, Kimiko; Yamamoto, Isao; Yamada, Yoshihiro

    2009-04-01

    Two severely burned human male bodies, possibly those of a parent and child, were recovered from the scene of a house fire and positive identification of the bodies was accomplished. This report describes the appropriate use of effective identification methods that made this possible. Identification of a body involves comparison of antemortem and postmortem X-ray films or dental records. In cases of poorly preserved dental remains, or in the absence of antemortem dental records, forensic DNA testing can be done. In the present case the male thought to be the son was identified from an antemortem panoramic X-ray film provided by the family dentist, which matched every significant detail in the body. On the other hand, forensic DNA testing of a sample obtained from the father's burned body was done in comparison with a swab obtained from his older brother, as the victim had no dental records for the 5 years before his death. This was able to confirm his identity. Thus positive identification was established through a combination of these methods. Although positive identification from dental records is rapid and certain, it requires antemortem dental records. If these are not available, forensic DNA testing should be attempted. In laboratories of forensic odontology, facilities for identity confirmation from both dental characteristics and forensic DNA testing should be made available.

  8. Survey of herbal cannabis (marijuana) use in rheumatology clinic attenders with a rheumatologist confirmed diagnosis.

    Science.gov (United States)

    Ste-Marie, Peter A; Shir, Yoram; Rampakakis, Emmanouil; Sampalis, John S; Karellis, Angela; Cohen, Martin; Starr, Michael; Ware, Mark A; Fitzcharles, Mary-Ann

    2016-12-01

    Cannabinoids may hold potential for the management of rheumatic pain. Arthritis, often self-reported, is commonly cited as the reason for the use of medicinal herbal cannabis (marijuana). We have examined the prevalence of marijuana use among 1000 consecutive rheumatology patients with a rheumatologist-confirmed diagnosis and compared in an exploratory manner the clinical characteristics of medicinal users and nonusers. Current marijuana use, medicinal or recreational, was reported by 38 patients (3.8%; 95% CI: 2.8-5.2). Ever use of marijuana for medical purposes was reported by 4.3% (95% CI: 3.2-5.7), with 28 (2.8%; 95% CI: 1.9-4.0) reporting current medicinal use. Current medicinal users had a spectrum of rheumatic conditions, with over half diagnosed with osteoarthritis. Medicinal users were younger, more likely unemployed or disabled, and reported poorer global health. Pain report and opioid use was greater for users, but they had similar physician global assessment of disease status compared with nonusers. Medicinal users were more likely previous recreational users, with approximately 40% reporting concurrent recreational use. Therefore, less than 3% of rheumatology patients reported current use of medicinal marijuana. This low rate of use in patients with a rheumatologist-confirmed diagnosis is in stark contrast to the high rates of severe arthritis frequently reported by medicinal marijuana users, especially in Canada. Familiarity with marijuana as a recreational product may explain use for some as disease status was similar for both groups.

  9. Psoriasis or not? Review of 51 clinically confirmed cases reveals an expanded histopathologic spectrum of psoriasis.

    Science.gov (United States)

    Chau, Thinh; Parsi, Kory K; Ogawa, Toru; Kiuru, Maija; Konia, Thomas; Li, Chin-Shang; Fung, Maxwell A

    2017-12-01

    Psoriasis is usually diagnosed clinically, so only non-classic or refractory cases tend to be biopsied. Diagnostic uncertainty persists when dermatopathologists encounter features regarded as non-classic for psoriasis. Define and document classic and non-classic histologic features in skin biopsies from patients with clinically confirmed psoriasis. Minimal clinical diagnostic criteria were informally validated and applied to a consecutive series of biopsies histologically consistent with psoriasis. Clinical confirmation required 2 of the following criteria: (1) classic morphology, (2) classic distribution, (3) nail pitting, and (4) family history, with #1 and/or #2 as 1 criterion in every case RESULTS: Fifty-one biopsies from 46 patients were examined. Classic features of psoriasis included hypogranulosis (96%), club-shaped rete ridges (96%), dermal papilla capillary ectasia (90%), Munro microabscess (78%), suprapapillary plate thinning (63%), spongiform pustules (53%), and regular acanthosis (14%). Non-classic features included irregular acanthosis (84%), junctional vacuolar alteration (76%), spongiosis (76%), dermal neutrophils (69%), necrotic keratinocytes (67%), hypergranulosis (65%), neutrophilic spongiosis (61%), dermal eosinophils (49%), compact orthokeratosis (37%), papillary dermal fibrosis (35%), lichenoid infiltrate (25%), plasma cells (16%), and eosinophilic spongiosis (8%). Psoriasis exhibits a broader histopathologic spectrum. The presence of some non-classic features does not necessarily exclude the possibility of psoriasis. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Implementation of point-of-care testing in a general internal medicine practice: A confirmation study.

    Science.gov (United States)

    Lewandrowski, Elizabeth-Lee; Yeh, Sunu; Baron, Jason; Benjamin Crocker, J; Lewandrowski, Kent

    2017-10-01

    In a previous study we reported on the impact of point-of-care testing (POCT) on practice efficiency in an academic primary care practice that was established to develop new models of care delivery. Here we report a follow-on confirmation study in a more typical primary care practice in the community. In this observational study with a retrospective comparison analysis we measured metrics of practice efficiency on two patient cohorts: those that did not receive POCT and those that did. In the patient cohort that received POCT there was a 99% reduction in letters to patients (ptests per visit (p=0.044) and a 38% reduction in follow-up visits due to abnormal test results (p=0.178). Financial analysis including testing costs, revenues and efficiency gains to the practice demonstrated a net financial benefit of $11.90-14.74 per patient visit. Our data confirm the earlier published findings that POCT can improve metrics of practice efficiency in a primary care practice. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Confirmed identification and toxin profiling of Campylobacter jejuni using a thermostabilized multiplex PCR formulation.

    Science.gov (United States)

    Ramachandran, Nitya; Ramlal, Shylaja; Batra, Harsh Vardhan

    2017-07-01

    Cytolethal distending toxin (CDT) producing Campylobacter jejuni species are one of the leading causes of human gastroenteritis worldwide. The main intent of the study was to develop a multiplex PCR assay for the confirmed identification and toxin profiling of C. jejuni. The genes targeted were rpo B as genus specific, hip O for species; cdt A, cdt B, cdt C encoding respective subunit proteins of CDT with Internal Amplification Control (IAC). To enhance its application as a pre-mixed ready-to-use format, the master mix of developed mPCR was dried by lyophilization and stability was assessed. Thermostabilized reagents showed stability of 1.5 months at room-temperature and upto six months at 4 °C without any loss of functionality. The assay was evaluated on a number of presumptive Campylobacter isolates along with biochemical tests. Results obtained indicated the accurate identification of C. jejuni by developed mPCR format in contrast to misconception associated with biochemical assays. The assay was also tested on spiked samples for its real-time utility. Altogether, the room-temperature storable and ready-to- use mPCR format developed in this study could be preferred for rapid detection and confirmed identification of toxigenic strains of C. jejuni in place of conventional biochemical assays. © 2017 APMIS. Published by John Wiley & Sons Ltd.

  12. A CATALOG OF NEW SPECTROSCOPICALLY CONFIRMED MASSIVE OB STARS IN CARINA

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Michael J.; Hanes, Richard J.; McSwain, M. Virginia [Department of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA 18015 (United States); Povich, Matthew S., E-mail: alexamic@lafayette.edu, E-mail: rjh314@lehigh.edu, E-mail: mcswain@lehigh.edu, E-mail: mspovich@cpp.edu [Department of Physics and Astronomy, California State Polytechnic University, Pomona, CA 91768 (United States)

    2016-12-01

    The Carina star-forming region is one of the largest in the Galaxy, and its massive star population is still being unveiled. The large number of stars combined with high, and highly variable, interstellar extinction makes it inherently difficult to find OB stars in this type of young region. We present the results of a spectroscopic campaign to study the massive star population of the Carina Nebula, with the primary goal to confirm or reject previously identified Carina OB star candidates. A total of 141 known O- and B-type stars and 94 candidates were observed, of which 73 candidates had high enough signal-to-noise ratio to classify. We find 23 new OB stars within the Carina Nebula, a 32% confirmation rate. One of the new OB stars has blended spectra and is suspected to be a double-lined spectroscopic binary (SB2). We also reclassify the spectral types of the known OB stars and discover nine new SB2s among this population. Finally, we discuss the spatial distribution of these new OB stars relative to known structures in the Carina Nebula.

  13. The comparison study between FDG fusion PET and CT in patients with confirmed salivary gland cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bom Sahn; Gang, Won Jun; Oh, So Won; Lee, Jeong Won; Lee, Dong Soo; Chung, June Key; Lee, Myung Chul [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2007-07-01

    It is well known that FDG Fusion PET (PET) has a good diagnostic nature in patient with head and neck cancer. But, there is a few PET study about salivary gland cancer which had a different histopathology. We analyzed the usefulness of PET in patients with biopsy confirmed salivary gland cancer. Eleven patients (M: F=8: 3, age = 61.29.3 yr) with PET and CT exam were enrolled (The interval=4263 day). All of them didn't have previous chemotherapy or radiotherapy. PET and CT were compared with pathologic TNM stage. All of eleven patients had salivary gland biopsy and confirmed as malignancy (parotid gland: submandibular gland =8: 3). Pathologic type was adenocarcinoma (1), poor differentiated carcinoma (1), mucoepidermoid carcinoma (n=2), adenoid cystic carcinoma (2), salivary duct carcinoma (2), carcinoma ex pleomorhic adenoma (3). One patient didn't operation due to metastatic lesions which was detected on PET. From 10 patients, PET had a 100 % of tumor detection rate (maxSUV =4.72.1) and 60 %(6/10) of coincident result with pathologic N stage. CT had 100 % of tumor detection rate and 40% (4/10) and 60 % (6/10) of coincidence results with TN stage. Even though PET didn't have a better coincidence with pathologic N stage than that of CT, it is useful method to discriminate metastatic lesion.

  14. Design stage confirmation of lifetime improvement for newly modified products through accelerated life testing

    International Nuclear Information System (INIS)

    Mohammadian, S. Hossein; Ait-Kadi, Daoud

    2010-01-01

    After a modification to the original version of a product and before mass production, the expected improvement in the product lifetime or reliability needs to be validated. This paper presents three approaches based on accelerated life testing to verify, estimate and confirm the lifetime or reliability of a newly modified product at design stage: ALT comparative approach, reliability estimation approach, and reliability validation test. Test samples of the original and modified versions are expected to fail during the tests in order to obtain their failure time data. In ALT comparative approach, the statistical comparison between failure time data of the original and modified versions is used to verify the required improvement in lifetime. In reliability estimation approach, the relationship made between available lifetime and failure time data of the original version is used to extrapolate lifetime data of the modified version from its failure time data. Since modified versions are usually highly reliable, all test samples might survive the tests (without any failures) that results in the lack of failure time data for statistical analysis. To confirm a level of service reliability with confidence, reliability validation test is presented to make an estimate of the number of samples required to survive the tests. To fulfill the same level of confidence for fewer number of prototypes (as test samples), the test time must be extended. On the other hand, more prototypes are needed to pass a shorter test time if there are any time constraints.

  15. Patients with multiple contact allergies

    DEFF Research Database (Denmark)

    Carlsen, Berit Christina; Andersen, Klaus Ejner; Menné, Torkil

    2008-01-01

    Patients with multiple contact allergies, also referred to as polysensitized, are more frequent than predicted from prevalence of single sensitivities. The understanding of why some people develop multiple contact allergies, and characterization of patients with multiple contact allergies...... of developing multiple contact allergies. Evidence of allergen clusters among polysensitized individuals is also reviewed. The literature supports the idea that patients with multiple contact allergies constitute a special entity within the field of contact allergy. There is no generally accepted definition...... of patients with multiple contact allergies. We suggest that contact allergy to 3 or more allergens are defined as multiple contact allergies....

  16. Multiples waveform inversion

    KAUST Repository

    Zhang, Dongliang

    2013-01-01

    To increase the illumination of the subsurface and to eliminate the dependency of FWI on the source wavelet, we propose multiples waveform inversion (MWI) that transforms each hydrophone into a virtual point source with a time history equal to that of the recorded data. These virtual sources are used to numerically generate downgoing wavefields that are correlated with the backprojected surface-related multiples to give the migration image. Since the recorded data are treated as the virtual sources, knowledge of the source wavelet is not required, and the subsurface illumination is greatly enhanced because the entire free surface acts as an extended source compared to the radiation pattern of a traditional point source. Numerical tests on the Marmousi2 model show that the convergence rate and the spatial resolution of MWI is, respectively, faster and more accurate then FWI. The potential pitfall with this method is that the multiples undergo more than one roundtrip to the surface, which increases attenuation and reduces spatial resolution. This can lead to less resolved tomograms compared to conventional FWI. The possible solution is to combine both FWI and MWI in inverting for the subsurface velocity distribution.

  17. Localized cutaneous mucinosis associated with multiple myeloma: A rare presentation

    Directory of Open Access Journals (Sweden)

    Parvaiz Anwar Rather

    2014-01-01

    Full Text Available Lichen myxoedematosus (LM, a form of primary cutaneous mucinosis, may present either as localized less severe form called papular mucinosis or diffuse more severe form called scleromyxoedema. The diffuse form is almost always associated with monoclonal gammopathy, whereas localized form is not. We report an atypical case of localized form of LM associated with multiple myeloma in a 66-year-old male, who presented with asymptomatic waxy papular eruption on extremities, which on histopathological examination confirmed the diagnosis of cutaneous mucinosis. After initially being put on steroids and hydroxychloroquine with minimal improvement, patient subsequently presented with encephalopathy and on evaluation revealed hypernatremia, hypercalcemia, hypergammaglobulinemia, reversal of albumin-globulin (A/G ratio, azotemia, and lytic lesions in skull X-ray. Bone marrow aspiration and biopsy confirmed multiple myeloma. Patient was successfully treated with standard treatment regimen for multiple myeloma with bortezumib and dexamethasone and his skin lesions subsided completely.

  18. Cardiotoxicity associated with the synthetic cannabinoid, K9, with laboratory confirmation.

    Science.gov (United States)

    Young, Amy C; Schwarz, Evan; Medina, Genevieve; Obafemi, Adebisi; Feng, Sing-Yi; Kane, Colin; Kleinschmidt, Kurt

    2012-09-01

    Synthetic cannabinoids have been popular recreational drugs of abuse for their psychoactive properties. Five of the many synthetic cannabinoids have been recently banned in the United States because of their unknown and potentially harmful adverse effects. Little is known about these substances. They are thought to have natural cannabinoid-like effects but have different chemical structures. Adverse effects related to synthetic cannabinoids are not well known. We provide clinical effects and patient outcome following K9 use. In addition, we briefly review synthetic cannabinoids. We present a 17-year-old adolescent boy with chest pain, tachycardia, and then bradycardia associated with smoking K9. Two synthetic cannabinoids, JWH-018 and JWH-073, were confirmed on laboratory analysis. In addition to the limited current data, we demonstrate harmful adverse effects related to toxicity of 2 synthetic cannabinoids. Further studies are needed. Published by Elsevier Inc.

  19. 18F-FDG-PET Scanning Confirmed Infected Intracardiac Device-Leads with Abiotrophia defectiva

    Directory of Open Access Journals (Sweden)

    Sonja van Roeden

    2016-01-01

    Full Text Available Abiotrophia species are relatively slow growing pathogens, which may be present as commensal flora. However, invasive infections are frequently reported, like endocarditis, septic arthritis, osteomyelitis, and many other types of infection. In this case report we describe a 65-year-old male patient with an intracardiac device- (ICD- lead infection caused by Abiotrophia defectiva. Diagnosis was confirmed by 18F-FDG-PET scanning. This is remarkable, since Abiotrophia defectiva is a slow growing pathogen causing low-grade infections. This case demonstrates that although infection of ICD-leads cannot be excluded in case of 18F-FDG-PET-negative findings, positive findings are highly suggestive for infection.

  20. Surgical protocol for confirmed or suspected cases of Ebola and other highly transmissible diseases.

    Science.gov (United States)

    Badia, Josep M; Rubio-Pérez, Inés; Arias Díaz, Javier; Guirao Garriga, Xavier; Serrablo, Alejandro; Jover Navalón, José M

    2016-01-01

    Outbreaks of viral haemorrhagic fevers such as Ebola can lead to imported cases in Europe and America. The eventuality of surgery in the setting of Ebola Virus Disease (EVD) is low, but the Spanish Association of Surgeons elaborated a surgical protocol for EVD. Elective surgical procedures are not indicated. Emergency cases can be considered in: persons under investigation, possible cases and early confirmed cases. In some conditions usually treated by surgery a medical treatment can be tested. All cases must be treated in high technology hospitals. These hospitals must be equipped with adequate means for healthcare provider's protection. All members of the healthcare team should practice thorough simulation prior to caring for a possible Ebola patient. This protocol is based on international guidelines on use of Personal Protective Equipment, protocols of other scientific societies, and specific recommendations for the operating room environment. Copyright © 2015 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  1. Detection and confirmation of ractopamine and its metabolites in horse urine after Paylean administration.

    Science.gov (United States)

    Lehner, A F; Hughes, C G; Harkins, J D; Nickerson, C; Mollett, B; Dirikolu, L; Bosken, J; Camargo, F; Boyles, J; Troppmann, A; Karpiesiuk, W W; Woods, W E; Tobin, T

    2004-01-01

    We have investigated the detection, confirmation, and metabolism of the beta-adrenergic agonist ractopamine administered as Paylean to the horse. A Testing Components Corporation enzyme-linked imunosorbent assay (ELISA) kit for ractopamine displayed linear response between 1.0 and 100 ng/mL with an I-50 of 10 ng/mL and an effective screening limit of detection of 50 ng/mL. The kit was readily able to detect ractopamine equivalents in unhydrolyzed urine up to 24 h following a 300-mg oral dose. Gas chromatography-mass spectrometry (GC-MS) confirmation comprised glucuronidase treatment, solid-phase extraction, and trimethylsilyl derivatization, with selected-ion monitoring of ractopamine-tris(trimethylsilane) (TMS) m/z 267, 250, 179, and 502 ions. Quantitation was elaborated in comparison to a 445 Mw isoxsuprine-bis(TMS) internal standard monitored simultaneously. The instrumental limit of detection, defined as that number of ng on column for which signal-to-noise ratios for one or more diagnostic ions fell below a value of three, was 0.1 ng, corresponding to roughly 5 ng/mL in matrix. Based on the quantitation ions for ractopamine standards extracted from urine, standard curves showed a linear response for ractopamine concentrations between 10 and 100 ng/mL with a correlation coefficient r > 0.99, whereas standards in the concentration range of 10-1000 ng/mL were fit to a second-order regression curve with r > 0.99. The lower limit of detection for ractopamine in urine, defined as the lowest concentration at which the identity of ractopamine could be confirmed by comparison of diagnostic MS ion ratios, ranged between 25 and 50 ng/mL. Urine concentration of parent ractopamine 24 h post-dose was measured at 360 ng/mL by GC-MS after oral administration of 300 mg. Urinary metabolites were identified by electrospray ionization (+) tandem quadrupole mass spectrometry and were shown to include glucuronide, methyl, and mixed methyl-glucuronide conjugates. We also considered

  2. Confirmation of occurrence of Babesia vogeli in a dog in Windhoek, central Namibia.

    Science.gov (United States)

    Penzhorn, Barend L; Vorster, Ilse; Redecker, Gernot; Oosthuizen, Marinda C

    2016-10-26

    Although there is evidence of high seroprevalence of antibodies to Babesia spp. in dogs in central Namibia, clinical babesiosis is rarely diagnosed. Rhipicephalus sanguineus sensu lato, the vector of Babesia vogeli, is common in Namibia while Haemaphysalis elliptica, the vector of the highly virulent but morphologically indistinguishable Babesia rossi, has rarely been recorded, mainly in northern Namibia. On the basis of vector occurrence, clinical cases of canine babesiosis in Windhoek, central Namibia, have been ascribed to B. vogeli. DNA extracted from a blood smear made from a sick dog was subjected to the reverse line blot hybridisation assay. The polymerase chain reaction amplicons hybridised with the B. vogeli-specific probe, but not with the Babesia canis- and B. rossi-specific probes. Although attempts at cloning and sequencing of the full-length 18S rRNA gene were unsuccessful, we can confirm that B. vogeli occurs in central Namibia.

  3. Confirmation of occurrence of Babesia vogeli in a dog in Windhoek, central Namibia

    Directory of Open Access Journals (Sweden)

    Barend L. Penzhorn

    2016-10-01

    Full Text Available Although there is evidence of high seroprevalence of antibodies to Babesia spp. in dogs in central Namibia, clinical babesiosis is rarely diagnosed. Rhipicephalus sanguineus sensu lato, the vector of Babesia vogeli, is common in Namibia while Haemaphysalis elliptica, the vector of the highly virulent but morphologically indistinguishable Babesia rossi, has rarely been recorded, mainly in northern Namibia. On the basis of vector occurrence, clinical cases of canine babesiosis in Windhoek, central Namibia, have been ascribed to B. vogeli. DNA extracted from a blood smear made from a sick dog was subjected to the reverse line blot hybridisation assay. The polymerase chain reaction amplicons hybridised with the B. vogeli–specific probe, but not with the Babesia canis– and B. rossi–specific probes. Although attempts at cloning and sequencing of the full-length 18S rRNA gene were unsuccessful, we can confirm that B. vogeli occurs in central Namibia.

  4. Measuring Positive and Negative Occupational States (PNOSI: Structural Confirmation of a New Belgian Tool

    Directory of Open Access Journals (Sweden)

    Marie Barbier

    2010-12-01

    Full Text Available This article reports on the validation of the Positive and Negative Occupational States Inventory (PNOSI, a new tool for measuring positive and negative occupational states. Three goals were defined: testing the structural validity of the PNOSI, testing its stability, and testing its convergent and discriminant validity with engagement, burnout, commitment, and workaholism. Data were collected in seven different companies (more than 16,000 participants. The factorial validity of the PNOSI was demonstrated using covariance structure analyses. A two-factor model with a negative occupational state factor and a positive occupational state factor fitted the data better than an alternative one-factor model. The two corresponding scales demonstrated good internal consistency. The results confirmed that positive and negative occupational states are distinct constructs and should be measured with different items. Convergent and discriminant validity with related constructs, namely engagement, burnout, commitment, and workaholism, were also demonstrated. The conclusion is that the PNOSI has good psychometric properties.

  5. Confirmation of Soluble Sulfate at the Phoenix Landing Site: Implications for Martian Geochemistry and Habitability

    Science.gov (United States)

    Kounaves, S. P.; Hecht, M. H.; Kapit, J.; Quinn, R. C.; Catling, D. C.; Clark, B. C.; Ming, D. W.; Gospodinova, K.; Hredzak, P.; McElhoney, K.; hide

    2010-01-01

    Over the past several decades, elemental sulfur in martian soils and rocks has been detected by a number of missions using X-ray spectroscopy [1-3]. Optical spectroscopy has also provided evidence for widespread sulfates on Mars [4,5]. The ubiquitous presence of sulfur in soils has been interpreted as a widely distributed sulfate mineralogy [6]. However, direct confirmation as to the identity and solubility of the sulfur species in martian soil has never been obtained. One goal of the Wet Chemistry Laboratory (WCL) [7] on board the 2007 Phoenix Mars Lander [8] was to determine soluble sulfate in the martian soil. The WCL received three primary samples. Each sample was added to 25 mL of leaching solution and analysed for solvated ionic species, pH, and conductivity [9,10]. The analysis also showed a discrepancy between charge balance, ionic strength, and conductivity, suggesting unidentified anionic species.

  6. Infective endocarditis caused by Neisseria elongata on a native tricuspid valve and confirmed by DNA sequencing.

    Science.gov (United States)

    Yoo, Yeon Pyo; Kang, Ki-Woon; Yoon, Hyeon Soo; Yoo, Seungmin; Lee, Myung-Shin

    2014-04-01

    Neisseria elongata, a common oral bacterium, has been recognized as a cause of infections such as infective endocarditis, septicemia, and osteomyelitis. Neisseria-induced infective endocarditis, although infrequently reported, typically arises after dental procedures. Without antibiotic therapy, its complications can be severe. We report the case of a 27-year-old man who presented with fever, severe dyspnea, and a leg abscess from cellulitis. An echocardiogram showed a vegetation-like echogenic structure on the septal leaflet of the patient's native tricuspid valve, and an insignificant Gerbode defect. Three blood cultures grew gram-negative, antibiotic-susceptible coccobacilli that were confirmed to be N. elongata. Subsequent DNA sequencing conclusively isolated N. elongata subsp nitroreducens as the organism responsible for the infective endocarditis. The patient recovered after 21 days of antibiotic therapy. In addition to the patient's unusual case, we discuss the nature and isolation of N. elongata and its subspecies.

  7. Molecular comparison of topotypic specimens confirms Anopheles (Nyssorhynchus dunhami Causey (Diptera: Culicidae in the Colombian Amazon

    Directory of Open Access Journals (Sweden)

    Freddy Ruiz

    2010-11-01

    Full Text Available The presence of Anopheles (Nyssorhynchus dunhami Causey in Colombia (Department of Amazonas is confirmed for the first time through direct comparison of mtDNA cytochrome c oxidase I (COI barcodes and nuclear rDNA second internal transcribed spacer (ITS2 sequences with topotypic specimens of An. dunhami from Tefé, Brazil. An. dunhami was identified through retrospective correlation of DNA sequences following misidentification as Anopheles nuneztovari s.l. using available morphological keys for Colombian mosquitoes. That An. dunhami occurs in Colombia and also possibly throughout the Amazon Basin, is of importance to vector control programs, as this non-vector species is morphologically similar to known malaria vectors including An. nuneztovari, Anopheles oswaldoi and Anopheles trinkae. Species identification of An. dunhami and differentiation from these closely related species are highly robust using either DNA ITS2 sequences or COI DNA barcode. DNA methods are advocated for future differentiation of these often sympatric taxa in South America.

  8. [Sexual orientation and partner-choice of transsexual women and men before gender-confirming interventions].

    Science.gov (United States)

    Cerwenka, Susanne; Nieder, Timo Ole; Richter-Appelt, Hertha

    2012-06-01

    Diverse partner relationship constellations of gender dysphoric women and men with different sexual orientations are explored in a sample of 93 persons before gender-confirming interventions in persons with female gender identity and male body characteristics (MF) and persons with male gender identity and female body characteristics (FM). While in both gender groups the majority is single, relationship patterns show differences. Apart from working life, FM already live predominantly in the new, male gender role and have partners by whom they are desired as males. In contrast, only a small proportion of MF already conduct their private lives in the new, female gender role, and they often have relationships with partners sexually attracted to males and not to their female gender identity. The findings indicate a need for differing resources for gender dysphoric women and men in the process of a transsexual course of development. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Data on association between QRS duration on prehospital ECG and mortality in patients with confirmed STEMI

    Directory of Open Access Journals (Sweden)

    Rikke Hansen

    2017-12-01

    Full Text Available Data presented in this article relates to the research article entitled “Association between QRS duration on prehospital ECG and mortality in patients with suspected STEMI” (Hansen et al., in press [1].Data on the prognostic effect of automatically recoded QRS duration on prehospital ECG and presence of classic left and right bundle branch block in 1777 consecutive patients with confirmed ST segment elevation AMI is presented. Multivariable analysis, suggested that QRS duration >111 ms, left bundle branch block and right bundle branch block were independent predictors of 30 days all-cause mortality. For interpretation and discussion of these data, refer to the research article referenced above.

  10. Genetic Confirmation of the Role of Sulfopyruvate Decarboxylase in Coenzyme M Biosynthesis in Methanococcus maripaludis

    Directory of Open Access Journals (Sweden)

    Felipe Sarmiento

    2013-01-01

    Full Text Available Coenzyme M is an essential coenzyme for methanogenesis. The proposed biosynthetic pathway consists of five steps, of which the fourth step is catalyzed by sulfopyruvate decarboxylase (ComDE. Disruption of the gene comE by transposon mutagenesis resulted in a partial coenzyme M auxotroph, which grew poorly in the absence of coenzyme M and retained less than 3% of the wild type level of coenzyme M biosynthesis. Upon coenzyme M addition, normal growth of the mutant was restored. Moreover, complementation of the mutation with the wild type comE gene in trans restored full growth in the absence of coenzyme M. These results confirm that ComE plays an important role in coenzyme M biosynthesis. The inability to yield a complete CoM auxotroph suggests that either the transposon insertion failed to completely inactivate the gene or M. maripaludis possesses a promiscuous activity that partially complemented the mutation.

  11. Genetic confirmation of the role of sulfopyruvate decarboxylase in coenzyme M biosynthesis in Methanococcus maripaludis.

    Science.gov (United States)

    Sarmiento, Felipe; Ellison, Courtney K; Whitman, William B

    2013-01-01

    Coenzyme M is an essential coenzyme for methanogenesis. The proposed biosynthetic pathway consists of five steps, of which the fourth step is catalyzed by sulfopyruvate decarboxylase (ComDE). Disruption of the gene comE by transposon mutagenesis resulted in a partial coenzyme M auxotroph, which grew poorly in the absence of coenzyme M and retained less than 3% of the wild type level of coenzyme M biosynthesis. Upon coenzyme M addition, normal growth of the mutant was restored. Moreover, complementation of the mutation with the wild type comE gene in trans restored full growth in the absence of coenzyme M. These results confirm that ComE plays an important role in coenzyme M biosynthesis. The inability to yield a complete CoM auxotroph suggests that either the transposon insertion failed to completely inactivate the gene or M. maripaludis possesses a promiscuous activity that partially complemented the mutation.

  12. Cerebral monoamine oxidase A inhibition in tobacco smokers confirmed with PET and [11C]Befloxatone

    International Nuclear Information System (INIS)

    Leroy, C.; Bragulat, V.; Penttila, J.; Artiges, E.; Martinot, J.L.; Trichard, Ch.; Leroy, C.; Bragulat, V.; Penttila, J.; Artiges, E.; Martinot, J.L.; Trichard, Ch.; Leroy, C.; Bragulat, V.; Penttila, J.; Artiges, E.; Martinot, J.L.; Trichard, Ch.; Berlin, I.; Gregoire, M.C.; Bottlaender, M.; Roumenov, D.; Dolle, F.; Bourgeois, S.; Artiges, E.; Trichard, Ch.

    2009-01-01

    The inhibition of cerebral monoamine oxidases (MAOs) by cigarette smoke components could participate to the tobacco addiction. However, the actual extent of this inhibition in vivo in smokers is still poorly known. We investigated cerebral MAO-A availability in 7 tobacco-dependent subjects and 6 healthy nonsmokers, using positron emission tomography (PET) and the MAO-A selective radioligand [ 11 C]befloxatone. In comparison to nonsmokers, smokers showed a significant overall reduction of [ 11 C]befloxatone binding potential (BP) in cortical areas (average reduction, -60%) and a similar trend in caudate and thalamus (-40%). Our findings confirm a widespread inhibition of cerebral MAO-A in smokers. This mechanism may contribute to tobacco addiction and for a possible mood-modulating effect of tobacco. (authors)

  13. Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

    Directory of Open Access Journals (Sweden)

    Warhurst David C

    2002-02-01

    Full Text Available Abstract We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone®. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01 was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.

  14. Immunodiagnostic confirmation of hydatid disease in patients with a presumptive diagnosis of injection

    Energy Technology Data Exchange (ETDEWEB)

    Varela-Diaz, V.M.; Coltorti, E.A.

    Information obtained from the routine application of hydatid immunodiagnostic techniques in different clinical situations over a seven-year period is presented. The immunoelectrophoresis test was used and was replaced by the arc 5 double diffusion (DD5) test. Examination of sera from 1.888 patients with signs and/or symptoms comparatible with hydatid disease revealed that the presurgical confirmation of Echinococcus granulosus infection is only obtained by detection of anti-antigen 5 antibodies. In all patients whose preoperative serum showed three or more uncharacteristic bands in the absence of anti-antigen 5 antibodies, hydatid cysts were found surgically. DD5 testing of a fluid sample collected by puncture estabilished its hydatid etiology. Post-operative monitoring of hydatidosis patients demonstrated that persistence of DD5-positivity two years after surgery established the presence of ther cysts.

  15. Confirmation of occurrence of Babesia vogeli in a dog in Windhoek, central Namibia

    Directory of Open Access Journals (Sweden)

    Barend L. Penzhorn

    2016-02-01

    Full Text Available Although there is evidence of high seroprevalence of antibodies to Babesia spp. in dogs in central Namibia, clinical babesiosis is rarely diagnosed. Rhipicephalus sanguineus sensu lato, the vector of Babesia vogeli, is common in Namibia while Haemaphysalis elliptica, the vector of the highly virulent but morphologically indistinguishable Babesia rossi, has rarely been recorded, mainly in northern Namibia. On the basis of vector occurrence, clinical cases of canine babesiosis in Windhoek, central Namibia, have been ascribed to B. vogeli. DNA extracted from a blood smear made from a sick dog was subjected to the reverse line blot hybridisation assay. The polymerase chain reaction amplicons hybridised with the B. vogeli–specific probe, but not with the Babesia canis– and B. rossi–specific probes. Although attempts at cloning and sequencing of the full-length 18S rRNA gene were unsuccessful, we can confirm that B. vogeli occurs in central Namibia.

  16. [Chikungunya fever in Mexico: confirmed case and notes on the epidemiologic response].

    Science.gov (United States)

    Rivera-Ávila, Roberto Carlos

    2014-01-01

    Chikungunya fever (CHIK) is a viral disease transmitted to human beings by the same vector as dengue -the Aedes mosquito. Besides fever and severe pain in the joints, it produces other symptoms such as myalgias, headache, nausea, fatigue and exanthema. There is no specific treatment for it; the therapeutic management of patients focuses on symptom relief. Historically, outbreaks of large proportions have been reported; even since 2010 it was considered to be a potential emerging epidemic. In 2013 it was introduced into the islands of the Caribbean, and it has recently been reported in the American continent. This paper describes the first confirmed case of chikungunya in Mexico -in the municipality of Tlajomulco de Zúñiga, Jalisco, in May, 2014-, which was imported from the Caribbean island of Antigua and Barbuda by a 39 year-old woman.

  17. Programmatic challenges in obtaining and confirming the pneumococcal vaccination status of cochlear implant recipients.

    Science.gov (United States)

    Carpenter, Ryan M; Limb, Charles J; Francis, Howard W; Gottschalk, Barbara; Niparko, John K

    2010-10-01

    Bacterial meningitis represents a substantial concern for individuals with cochlear implants (CIs). Chart review and direct patient and family correspondence to ascertain vaccination status. Information dissemination via brochure and electronic media, ongoing reminders of the importance of vaccination when confirmation of vaccination was not received. Marked improvement in vaccination rates ranging from 49% to 99% across different patient populations. Importantly, many patients received their vaccinations only after follow-up reminders. Ensuring optimal vaccination of all CI recipients against high-risk pathogens is a significantly challenging task. Maximizing vaccination rates in CI users will require an ongoing, active effort of information dissemination, documentation of compliance, and well-designed behavioral systems to streamline the pragmatic challenges in vaccination delivery.

  18. 87Sr enrichment of ophiolitic sulphide deposits in Cyprus confirms ore formation by circulating seawater

    International Nuclear Information System (INIS)

    Chapman, H.J.; Spooner, E.T.C.

    1977-01-01

    The hypothesis that seawater was the source of the hydrothermal fluid which formed the Upper Cretaceous ophiolitic cupriferous pyrite ore deposits of the Troodos Massif (Cyprus) has been tested by analysing the strontium isotopic composition of thirteen mineralized samples from four mines. Initial 87 Sr/ 86 Sr ratios range from 0.7052+-0.0001 to 0.7075+-0.00002, the latter value being indistinguishable from that of Upper Cretaceous seawater at 0.7076+-0.0006 (2 sigma). Hence, the mineralized metabasalt samples have been contaminated with 87 Sr, relative to initial magmatic strontium isotope ratios of the Troodos ophiolitic complex (0.70338+-0.00010 to 0.70365+-0.00005). Since seawater was the only source of strontium available during formation of the Troodos Complex which was isotopically relatively enriched in 87 Sr, the data confirm that seawater was the source of the hydrothermal oreforming fluid. (Auth.)

  19. Confirmation that RIPK4 mutations cause not only Bartsocas-Papas syndrome but also CHAND syndrome.

    Science.gov (United States)

    Busa, Tiffany; Jeraiby, Mohammed; Clémenson, Alix; Manouvrier, Sylvie; Granados, Viviana; Philip, Nicole; Touraine, Renaud

    2017-11-01

    CHAND syndrome is an autosomal recessive disorder characterized by curly hair, ankyloblepharon, and nail dysplasia. Only few patients were reported to date. A homozygous RIPK4 mutation was recently identified by homozygosity mapping and whole exome sequencing in three patients from an expanded consanguineous kindred with a clinical diagnosis of CHAND syndrome. RIPK4 was previously known to be implicated in Bartsocas-Papas syndrome, the autosomal recessive form of popliteal pterygium syndrome. We report here two cases of RIPK4 homozygous mutations in a fetus with severe Bartsocas-Papas syndrome and a patient with CHAND syndrome. The patient with CHAND syndrome harbored the same mutation as the one identified in the family previously reported. We thus confirm the implication of RIPK4 gene in CHAND syndrome in addition to Bartsocas-Papas syndrome and discuss genotype/phenotype correlations. © 2017 Wiley Periodicals, Inc.

  20. Stereotype Strength and Attentional Bias: Preference for Confirming versus Disconfirming Information Depends on Processing Capacity

    Science.gov (United States)

    Allen, Thomas J.; Sherman, Jeffrey W.; Conrey, Frederica R.; Stroessner, Steven J.

    2009-01-01

    In two experiments, we investigated the relationships among stereotype strength, processing capacity, and the allocation of attention to stereotype-consistent versus stereotype-inconsistent information describing a target person. The results of both experiments showed that, with full capacity, greater stereotype strength was associated with increased attention toward stereotype-consistent versus stereotype-inconsistent information. However, when capacity was diminished, greater stereotype strength was associated with increased attention toward inconsistent versus consistent information. Thus, strong stereotypes may act as self-confirming filters when processing capacity is plentiful, but as efficient information gathering devices that maximize the acquisition of novel (disconfirming) information when capacity is depleted. Implications for models of stereotyping and stereotype change are discussed. PMID:20161043