Effects of stress on heart rate complexity--a comparison between short-term and chronic stress.

Science.gov (United States)

Schubert, C; Lambertz, M; Nelesen, R A; Bardwell, W; Choi, J-B; Dimsdale, J E

2009-03-01

This study examined chronic and short-term stress effects on heart rate variability (HRV), comparing time, frequency and phase domain (complexity) measures in 50 healthy adults. The hassles frequency subscale of the combined hassles and uplifts scale (CHUS) was used to measure chronic stress. Short-term stressor reactivity was assessed with a speech task. HRV measures were determined via surface electrocardiogram (ECG). Because respiration rate decreased during the speech task (pshort-term stress decreased HR D2 (calculated via the pointwise correlation dimension PD2) (pshort-term stress. Partial correlation adjusting for respiration rate showed that HR D2 was associated with chronic stress (r=-.35, p=.019). Differential effects of chronic and short-term stress were observed on several HRV measures. HR D2 decreased under both stress conditions reflecting lowered functionality of the cardiac pacemaker. The results confirm the importance of complexity metrics in modern stress research on HRV.

An Elongin-Cullin-SOCS Box Complex Regulates Stress-Induced Serotonergic Neuromodulation

Directory of Open Access Journals (Sweden)

Xicotencatl Gracida

2017-12-01

Full Text Available Neuromodulatory cells transduce environmental information into long-lasting behavioral responses. However, the mechanisms governing how neuronal cells influence behavioral plasticity are difficult to characterize. Here, we adapted the translating ribosome affinity purification (TRAP approach in C. elegans to profile ribosome-associated mRNAs from three major tissues and the neuromodulatory dopaminergic and serotonergic cells. We identified elc-2, an Elongin C ortholog, specifically expressed in stress-sensing amphid neuron dual ciliated sensory ending (ADF serotonergic sensory neurons, and we found that it plays a role in mediating a long-lasting change in serotonin-dependent feeding behavior induced by heat stress. We demonstrate that ELC-2 and the von Hippel-Lindau protein VHL-1, components of an Elongin-Cullin-SOCS box (ECS E3 ubiquitin ligase, modulate this behavior after experiencing stress. Also, heat stress induces a transient redistribution of ELC-2, becoming more nuclearly enriched. Together, our results demonstrate dynamic regulation of an E3 ligase and a role for an ECS complex in neuromodulation and control of lasting behavioral states.

Nurse manager cognitive decision-making amidst stress and work complexity.

Science.gov (United States)

Shirey, Maria R; Ebright, Patricia R; McDaniel, Anna M

2013-01-01

  The present study provides insight into nurse manager cognitive decision-making amidst stress and work complexity.   Little is known about nurse manager decision-making amidst stress and work complexity. Because nurse manager decisions have the potential to impact patient care quality and safety, understanding their decision-making processes is useful for designing supportive interventions.   This qualitative descriptive study interviewed 21 nurse managers from three hospitals to answer the research question: What decision-making processes do nurse managers utilize to address stressful situations in their nurse manager role? Face-to-face interviews incorporating components of the Critical Decision Method illuminated expert-novice practice differences. Content analysis identified one major theme and three sub-themes.   The present study produced a cognitive model that guides nurse manager decision-making related to stressful situations. Experience in the role, organizational context and situation factors influenced nurse manager cognitive decision-making processes.   Study findings suggest that chronic exposure to stress and work complexity negatively affects nurse manager health and their decision-making processes potentially threatening individual, patient and organizational outcomes.   Cognitive decision-making varies based on nurse manager experience and these differences have coaching and mentoring implications. This present study contributes a current understanding of nurse manager decision-making amidst stress and work complexity. © 2012 Blackwell Publishing Ltd.

Atypical stress-avulsion fracture of the Lisfranc joint complex.

LENUS (Irish Health Repository)

O'Neill, Barry J

2014-04-01

Antiphospholipid syndrome and systemic erythematosus have been associated with metatarsal stress fractures. Stress fractures of the Lisfranc joint complex are uncommon injuries but have been reported to occur most frequently in ballet dancers. We present a case of an avulsion fracture of the Lisfranc joint complex that occurred spontaneously. We have reviewed the association between systemic conditions and metatarsal fractures and proposed a series of hypothetical pathological events that may have contributed to this unusual injury.

New Modeling of Steady-State Modes of Complex Electrical Grids of Power Systems

Directory of Open Access Journals (Sweden)

Akhmetbayev Arman

2018-01-01

Full Text Available Classical methods for modeling the steady-state modes of complex electrical networks and systems are based on the application of nonlinear node equations. Nonlinear equations are solved by iterative methods, which are connected by known difficulties. To a certain extent, these difficulties can be weakened by applying topological methods. In this paper, we outline the theoretical foundations for the formation of the inverse form of nodal stress equations based on the topology of electrical networks and systems. A new topological method for calculating the distribution coefficients of node currents is proposed based on all possible trees of a directed graph of a complex electrical network. A complex program for calculating current distribution coefficients and forming steady-state parameters in the MATLAB environment has been developed.

The State of Stress Beyond the Borehole

Science.gov (United States)

Johnson, P. A.; Coblentz, D. D.; Maceira, M.; Delorey, A. A.; Guyer, R. A.

2015-12-01

The state of stress controls all in-situ reservoir activities and yet we lack the quantitative means to measure it. This problem is important in light of the fact that the subsurface provides more than 80 percent of the energy used in the United States and serves as a reservoir for geological carbon sequestration, used fuel disposition, and nuclear waste storage. Adaptive control of subsurface fractures and fluid flow is a crosscutting challenge being addressed by the new Department of Energy SubTER Initiative that has the potential to transform subsurface energy production and waste storage strategies. Our methodology to address the above mentioned matter is based on a novel Advance Multi-Physics Tomographic (AMT) approach for determining the state of stress, thereby facilitating our ability to monitor and control subsurface geomechanical processes. We developed the AMT algorithm for deriving state-of-stress from integrated density and seismic velocity models and demonstrate the feasibility by applying the AMT approach to synthetic data sets to assess accuracy and resolution of the method as a function of the quality and type of geophysical data. With this method we can produce regional- to basin-scale maps of the background state of stress and identify regions where stresses are changing. Our approach is based on our major advances in the joint inversion of gravity and seismic data to obtain the elastic properties for the subsurface; and coupling afterwards the output from this joint-inversion with theoretical model such that strain (and subsequently) stress can be computed. Ultimately we will obtain the differential state of stress over time to identify and monitor critically stressed faults and evolving regions within the reservoir, and relate them to anthropogenic activities such as fluid/gas injection.

An updated stress map of the continental United States reveals heterogeneous intraplate stress

Science.gov (United States)

Levandowski, Will; Herrmann, Robert B.; Briggs, Rich; Boyd, Oliver; Gold, Ryan

2018-06-01

Knowledge of the state of stress in Earth's crust is key to understanding the forces and processes responsible for earthquakes. Historically, low rates of natural seismicity in the central and eastern United States have complicated efforts to understand intraplate stress, but recent improvements in seismic networks and the spread of human-induced seismicity have greatly improved data coverage. Here, we compile a nationwide stress map based on formal inversions of focal mechanisms that challenges the idea that deformation in continental interiors is driven primarily by broad, uniform stress fields derived from distant plate boundaries. Despite plate-boundary compression, extension dominates roughly half of the continent, and second-order forces related to lithospheric structure appear to control extension directions. We also show that the states of stress in several active eastern United States seismic zones differ significantly from those of surrounding areas and that these anomalies cannot be explained by transient processes, suggesting that earthquakes are focused by persistent, locally derived sources of stress. Such spatially variable intraplate stress appears to justify the current, spatially variable estimates of seismic hazard. Future work to quantify sources of stress, stressing-rate magnitudes and their relationship with strain and earthquake rates could allow prospective mapping of intraplate hazard.

Stress near geometrically complex strike-slip faults - Application to the San Andreas fault at Cajon Pass, southern California

Science.gov (United States)

Saucier, Francois; Humphreys, Eugene; Weldon, Ray, II

1992-01-01

A model is presented to rationalize the state of stress near a geometrically complex major strike-slip fault. Slip on such a fault creates residual stresses that, with the occurrence of several slip events, can dominate the stress field near the fault. The model is applied to the San Andreas fault near Cajon Pass. The results are consistent with the geological features, seismicity, the existence of left-lateral stress on the Cleghorn fault, and the in situ stress orientation in the scientific well, found to be sinistral when resolved on a plane parallel to the San Andreas fault. It is suggested that the creation of residual stresses caused by slip on a wiggle San Andreas fault is the dominating process there.

Fracture mechanics and residual fatigue life analysis for complex stress fields. Technical report

International Nuclear Information System (INIS)

Besuner, P.M.

1975-07-01

This report reviews the development and application of an influence function method for calculating stress intensity factors and residual fatigue life for two- and three-dimensional structures with complex stress fields and geometries. Through elastic superposition, the method properly accounts for redistribution of stress as the crack grows through the structure. The analytical methods used and the computer programs necessary for computation and application of load independent influence functions are presented. A new exact solution is obtained for the buried elliptical crack, under an arbitrary Mode I stress field, for stress intensity factors at four positions around the crack front. The IF method is then applied to two fracture mechanics problems with complex stress fields and geometries. These problems are of current interest to the electric power generating industry and include (1) the fatigue analysis of a crack in a pipe weld under nominal and residual stresses and (2) fatigue analysis of a reactor pressure vessel nozzle corner crack under a complex bivariate stress field

The Dissociative Subtype of Posttraumatic Stress Disorder: Unique Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes.

Science.gov (United States)

Nicholson, Andrew A; Densmore, Maria; Frewen, Paul A; Théberge, Jean; Neufeld, Richard Wj; McKinnon, Margaret C; Lanius, Ruth A

2015-09-01

Previous studies point towards differential connectivity patterns among basolateral (BLA) and centromedial (CMA) amygdala regions in patients with posttraumatic stress disorder (PTSD) as compared with controls. Here we describe the first study to compare directly connectivity patterns of the BLA and CMA complexes between PTSD patients with and without the dissociative subtype (PTSD+DS and PTSD-DS, respectively). Amygdala connectivity to regulatory prefrontal regions and parietal regions involved in consciousness and proprioception were expected to differ between these two groups based on differential limbic regulation and behavioral symptoms. PTSD patients (n=49) with (n=13) and without (n=36) the dissociative subtype and age-matched healthy controls (n=40) underwent resting-state fMRI. Bilateral BLA and CMA connectivity patterns were compared using a seed-based approach via SPM Anatomy Toolbox. Among patients with PTSD, the PTSD+DS group exhibited greater amygdala functional connectivity to prefrontal regions involved in emotion regulation (bilateral BLA and left CMA to the middle frontal gyrus and bilateral CMA to the medial frontal gyrus) as compared with the PTSD-DS group. In addition, the PTSD+DS group showed greater amygdala connectivity to regions involved in consciousness, awareness, and proprioception-implicated in depersonalization and derealization (left BLA to superior parietal lobe and cerebellar culmen; left CMA to dorsal posterior cingulate and precuneus). Differences in amygdala complex connectivity to specific brain regions parallel the unique symptom profiles of the PTSD subgroups and point towards unique biological markers of the dissociative subtype of PTSD.

Main results of BN-600 reactor stress-strain state investigations

International Nuclear Information System (INIS)

Panov, V.A.

1983-01-01

The development of BN-600 fast reactor plant needed the solution of a series of complex engineering problems including ones for confirming integrity of the most vital structural components. The particular attention was given to the main vessel since reactor availability end safe operation of the plant as a whole depend on vessel strength end integrity. The present report deals with the main results of theoretical and experimental investigations of the stress-strain state of BN-600 reactor vessel carried out during design, start-up and initial bringing the reactor to power

Global warming and stress complexes in forests of western North America

Science.gov (United States)

Donald McKenzie; David L. Peterson; Jeremy J. Littell

2009-01-01

A warmer climate in western North America will likely affect forests directly through soil moisture stress and indirectly through increased extent and severity of disturbances. We propose that stress complexes, combinations of biotic and abiotic stresses, compromise the vigor and ultimate sustainability of forest ecosystems. Across...

Children and adolescents treated for post-traumatic stress disorder at the Free State Psychiatric Complex

Directory of Open Access Journals (Sweden)

F J W Calitz

2014-04-01

Full Text Available Background. Children and adolescents can develop post-traumatic stress disorder (PTSD after exposure to a range of traumatic events, including domestic, political or community violence, violent crime, physical and sexual abuse, hijacking, witnessing a violent crime and motor vehicle accidents. This is particularly critical given the substantial challenge that PTSD poses to the healthy physical, cognitive and emotional development of children and adolescents. Methods. The clinical records of 1 229 children (age 2 - 11 years and adolescents (age 12 - 18 years treated at the Child Mental Health Unit of the Free State Psychiatric Complex (FSPC were screened for the diagnosis of PTSD and analysed for the purpose of this study. Results. Forty-nine (4.0% of the children and adolescents treated at the unit were diagnosed with PTSD, of whom most were female (63.3%. Approximately 22% of the participants had comorbid major depressive disorder. The main traumatic event in both groups was witnessing the death of a close relative (32.7%, followed by sexual assault (25%, rape (25% and physical attack (10.2%. Associated stressors identified included problems at school (55.1%, isolation (39%, fear or anxiety (37%, problematic family relationships (29%, emotional (27% and physical (23% abuse, and lack of social support (23%. Most of the participants (59.2% received psychotherapy. Conclusions. Children and adolescents referred to the FSPC are also exposed to traumatic events which lead to the development of PTSD. The Free State is a sprawling province with remote areas where specialist services and facilities are limited. It is therefore recommended that preventive programmes, training opportunities and consultation services are implemented to identify and treat children and adolescents with PTSD. Schools with limited access to psychological services and large classrooms, impeding the diagnosis and treatment of PTSD specifically, face similar challenges

Biaxial nominal state of stress at the crack front

International Nuclear Information System (INIS)

Dietmann, H.; Kussmaul, K.

1979-01-01

In fracture toughness testing with CT-specimens there is an unaxial nominal stress state caused by the nominal stress psub(y) perpendicular to the crack surface. This paper investigates the question whether the fracture toughness, or generally speaking, the fracture load, is influenced by additional nominal stresses psub(x) and psub(z) in the crack surface, i.e. by a multiaxial stress state. (orig.)

Effect of cyclic block loading on character of deformation and strength of structural materials in plane stressed state

International Nuclear Information System (INIS)

Kul'chitskij, N.M.; Troshchenko, A.V.; Koval'chuk, B.I.; Khamaza, L.A.; Nikolaev, I.A.

1982-01-01

The paper is concerned with choice of conditions for preliminary cyclic block loading, determination of fatigue failure resistance characteristics for various structural materials under regular and selected block loading, investigation of the preliminary cyclic loading effect on regularities of elastoplastic deformation of materials concerned in the biaxial stressed state. Under selected conditions of cyclic block loading the character of damage accumulation is close to the linear law for the materials of high-srength doped steel, and VT6 alloys of concern. These materials in the initial state and after preliminary cyclic loading are anisotropic. Axial direction is characterized by a higher plastic strain resistance for steel and tangential direction - for VT6 alloy. The generalized strain curves for the materials in question are not invariant as to the stressed state type. It is stated that the effect of preliminary unsteady cyclic loading on resistance and general regularities of material deformation in the complex stressed state is insignificant. It is observed that stress-strain properties of the materials tend to vary in the following way: plastic strain resistance of the steel lowers and that of VT6 rises, anisotropy of the materials somehow decreases. The variation in the material anisotropy may be attributed to a decrease in residual stresses resulting from preliminary cyclic loading

Tremor frequency characteristics in Parkinson's disease under resting-state and stress-state conditions.

Science.gov (United States)

Lee, Hong Ji; Lee, Woong Woo; Kim, Sang Kyong; Park, Hyeyoung; Jeon, Hyo Seon; Kim, Han Byul; Jeon, Beom S; Park, Kwang Suk

2016-03-15

Tremor characteristics-amplitude and frequency components-are primary quantitative clinical factors for diagnosis and monitoring of tremors. Few studies have investigated how different patient's conditions affect tremor frequency characteristics in Parkinson's disease (PD). Here, we analyzed tremor characteristics under resting-state and stress-state conditions. Tremor was recorded using an accelerometer on the finger, under resting-state and stress-state (calculation task) conditions, during rest tremor and postural tremor. The changes of peak power, peak frequency, mean frequency, and distribution of power spectral density (PSD) of tremor were evaluated across conditions. Patients whose tremors were considered more than "mild" were selected, for both rest (n=67) and postural (n=25) tremor. Stress resulted in both greater peak powers and higher peak frequencies for rest tremor (pstate condition. The distributions of PSD of tremor were symmetrical, regardless of conditions. Tremor is more evident and typical tremor characteristics, namely a lower frequency as amplitude increases, are different in stressful condition. Patient's conditions directly affect neural oscillations related to tremor frequencies. Therefore, tremor characteristics in PD should be systematically standardized across patient's conditions such as attention and stress levels. Copyright © 2016. Published by Elsevier B.V.

Unique insula subregion resting-state functional connectivity with amygdala complexes in posttraumatic stress disorder and its dissociative subtype.

Science.gov (United States)

Nicholson, Andrew A; Sapru, Iman; Densmore, Maria; Frewen, Paul A; Neufeld, Richard W J; Théberge, Jean; McKinnon, Margaret C; Lanius, Ruth A

2016-04-30

The insula and amygdala are implicated in the pathophysiology of posttraumatic stress disorder (PTSD), where both have been shown to be hyper/hypoactive in non-dissociative (PTSD-DS) and dissociative subtype (PTSD+DS) PTSD patients, respectively, during symptom provocation. However, the functional connectivity between individual insula subregions and the amygdala has not been investigated in persons with PTSD, with or without the dissociative subtype. We examined insula subregion (anterior, mid, and posterior) functional connectivity with the bilateral amygdala using a region-of-interest seed-based approach via PickAtlas and SPM8. Resting-state fMRI was conducted with (n=61) PTSD patients (n=44 PTSD-DS; n=17 PTSD+DS), and (n=40) age-matched healthy controls. When compared to controls, the PTSD-DS group displayed increased insula connectivity (bilateral anterior, bilateral mid, and left posterior) to basolateral amygdala clusters in both hemispheres, and the PTSD+DS group displayed increased insula connectivity (bilateral anterior, left mid, and left posterior) to the left basolateral amygdala complex. Moreover, as compared to PTSD-DS, increased insula subregion connectivity (bilateral anterior, left mid, and right posterior) to the left basolateral amygdala was found in PTSD+DS. Depersonalization/derealization symptoms and PTSD symptom severity correlated with insula subregion connectivity to the basolateral amygdala within PTSD patients. This study is an important first step in elucidating patterns of neural connectivity associated with unique symptoms of arousal/interoception, emotional processing, and awareness of bodily states, in PTSD and its dissociative subtype. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Correlation/Communication complexity of generating bipartite states

OpenAIRE

Jain, Rahul; Shi, Yaoyun; Wei, Zhaohui; Zhang, Shengyu

2012-01-01

We study the correlation complexity (or equivalently, the communication complexity) of generating a bipartite quantum state $\\rho$. When $\\rho$ is a pure state, we completely characterize the complexity for approximately generating $\\rho$ by a corresponding approximate rank, closing a gap left in Ambainis, Schulman, Ta-Shma, Vazirani and Wigderson (SIAM Journal on Computing, 32(6):1570-1585, 2003). When $\\rho$ is a classical distribution $P(x,y)$, we tightly characterize the complexity of gen...

The intersection of stress and reward: BNST modulation of aversive and appetitive states.

Science.gov (United States)

Ch'ng, Sarah; Fu, Jingjing; Brown, Robyn M; McDougall, Stuart J; Lawrence, Andrew J

2018-01-09

The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The diverse roles of the BNST are afforded by its highly modular organisation, neurochemical heterogeneity, and complex intrinsic and extrinsic circuitry. There has been growing interest in the BNST in relation to psychopathologies such as anxiety and addiction. Although research on the human BNST is still in its infancy, there have been extensive preclinical studies examining the molecular signature and hodology of the BNST and their involvement in stress and reward seeking behaviour. This review examines the neurochemical phenotype and connectivity of the BNST, as well as electrophysiological correlates of plasticity in the BNST mediated by stress and/or drugs of abuse. Copyright © 2018 Elsevier Inc. All rights reserved.

[Methods and Applications of Psychological Stress State Assessment].

Science.gov (United States)

Li, Xin; Yang, Yadan; Hou, Yongjie; Chen, Zetao

2015-08-01

In this paper, the response of individual's physiological system under psychological stress state is discussed, and the theoretical support for psychological stress assessment research is provided. The two methods, i.e., the psychological stress assessment of questionnaire and physiological parameter assessment used for current psychological stress assessment are summarized. Then, the future trend of development of psychological stress assessment research is pointed out. We hope that this work could do and provide further support and help to psychological stress assessment studies.

"Complex" Posttraumatic Stress Disorder/Disorders of Extreme Stress (CP/DES) in Sexually Abused Children: An Exloratory Study.

Science.gov (United States)

Hall, Darlene Kordich

1999-01-01

Compares three groups of young sexually abused children on seven "Complex" Posttraumatic Stress Disorder/Disorders of Extreme Stress (CP/DES) indices. As cumulative number of types of trauma increased, the number of CP/DES symptoms rose. Results suggest that CP/DES also characterizes sexually abused children, especially those who have…

Constitutive relations describing creep deformation for multi-axial time-dependent stress states

Science.gov (United States)

McCartney, L. N.

1981-02-01

A THEORY of primary and secondary creep deformation in metals is presented, which is based upon the concept of tensor internal state variables and the principles of continuum mechanics and thermodynamics. The theory is able to account for both multi-axial and time-dependent stress and strain states. The wellknown concepts of elastic, anelastic and plastic strains follow naturally from the theory. Homogeneous stress states are considered in detail and a simplified theory is derived by linearizing with respect to the internal state variables. It is demonstrated that the model can be developed in such a way that multi-axial constant-stress creep data can be presented as a single relationship between an equivalent stress and an equivalent strain. It is shown how the theory may be used to describe the multi-axial deformation of metals which are subjected to constant stress states. The multi-axial strain response to a general cyclic stress state is calculated. For uni-axial stress states, square-wave loading and a thermal fatigue stress cycle are analysed.

The influence of the stress state on Ksub(Ic)

International Nuclear Information System (INIS)

Aurich, D.; Helms, R.; Schmidt, P.; Veith, H.; Ziebs, J.

1977-01-01

To get a first impression of the influence of stress states of higher multi-axiality than plane strain on Ksub(c) a specimen has been created, in which a bi-axial nominal stress state arises by uniaxial tension. This is attained by tension superimposed by transverse bending stress. The stress distribution without crack was analysed by photoelasticity as well as by finite element method. The results were identical. The stress distribution in the fracture (crack) plane was somewhat inhomogeneous, of course. But the ratio of the stress parallel to the tension axis to that perpendicular to it was max. 1:0.3 with a mean value 1:0.15. Specimens of this type were machined from a rolled sheet of the steel 22 NiMoCr 37, with specimen thickness of about 50 mm. For comparison single-edge notched specimens of the same cross section were prepared from the same material. Fatigue cracks were made following ASTM Recommendations. The fracture mechanics tests were carried out at a temperature of -100 0 C. Although valid Ksub(Ic)-values following the rigorous intention of the linear elastic fracture mechanics (ASTM Recommendations) were not obtained, the differences between the results of the two types of specimens and stress states were significant. The Ksub(Q)-values of the bi-axial stressed specimen were about 25% lower than that of the single-edge notched specimen. The deviation of the load-displacement trace from the linear elastic behavior was greater for the single-edge notched specimens than for the bi-axial stressed specimens. The consequences of these results for the assessment of flaws in pressure vessels are evident considering that bi-axial nominal stress states occur in pressure vessels

A profile of perceived stress factors among nursing staff working with intellectually disabled in-patients at the Free State Psychiatric Complex, South Africa

Directory of Open Access Journals (Sweden)

Maria Conradie

2017-03-01

Full Text Available Introduction: Nursing staff working with intellectually disabled in-patients experience unique stress factors that can influence their personal well-being and work performance. Objectives: To compile a profile of stress factors experienced by nursing staff working with intellectually disabled in-patients at the Free State Psychiatric Complex (FSPC. Methods: This descriptive study included 89 nursing staff members from this environment. A questionnaire was used to collect socio-demographic information and determine personal and occupational stressors. The data were summarised by frequencies and percentages (categorical variables and means or percentiles (numerical variables. Results: Most participants were aged between 46 and 55 (41.2%, female (93.2% and black (93.2%, and 76.7% had children or dependant minors. The main stressors among participants were pressure providing financially for their children and dependant minors (71.2%, caring for them (39.4% and fearing them moving away (25.8%. Occupational stressors included high workload (66.3%, lack of decision-making by superiors (58.1%, underpayment (53.5%, endangerment of physical health (52.3% and safety (50.0%, working hours (51.2%, pressure of expectations from superiors (48.8%, uncertainty of employment (48.8%, work responsibilities (47.7% and perceiving that skills and training were not appreciated. They experienced stress regarding health issues such as hyper- and hypotension (35.3%. Because of stress 34.5% of participants took leave, 34.5% developed depression and 14.3% had panic attacks. Conclusion: Most of the respondents experienced personal and occupational stress that influenced their health, which poses serious challenges for the management of the FSPC. Security should be upgraded, medical and psychological support for the staff and care facilities for their dependants should be provided, and financial problems experienced by these staff members should be addressed. The workload of

Recent state of stress change in the Walker Lane zone, western Basin and Range province, United States

Science.gov (United States)

Bellier, Olivier; Zoback, Mary Lou

1995-06-01

The NW to north-trending Walker Lane zone (WLZ) is located along the western boundary of the northern Basin and Range province with the Sierra Nevada. This zone is distinguished from the surrounding Basin and Range province on the basis of irregular topography and evidence for both normal and strike-slip Holocene faulting. Inversion of slip vectors from active faults, historic fault offsets, and earthquake focal mechanisms indicate two distinct Quaternary stress regimes within the WLZ, both of which are characterized by a consistent WNW σ3 axis; these are a normal faulting regime with a mean σ3 axis of N85°±9°W and a mean stress ratio (R value) (R=(σ2-σ1)/(σ3-σ1)) of 0.63-0.74 and a younger strike-slip faulting regime with a similar mean σ3 axis (N65° - 70°W) and R values ranging between ˜ 0.1 and 0.2. This younger regime is compatible with historic fault offsets and earthquake focal mechanisms. Both the extensional and strike-slip stress regimes reactivated inherited Mesozoic and Cenozoic structures and also produced new faults. The present-day strike-slip stress regime has produced strike-slip, normal oblique-slip, and normal dip-slip historic faulting. Previous workers have explained the complex interaction of active strike-slip, oblique, and normal faulting in the WLZ as a simple consequence of a single stress state with a consistent WNW σ3 axis and transitional between strike-slip and normal faulting (maximum horizontal stress approximately equal to vertical stress, or R ≈ 0 in both regimes) with minor local fluctuations. The slip data reported here support previous results from Owens Valley that suggest deformation within temporally distinct normal and strike-slip faulting stress regimes with a roughly constant WNW trending σ3 axis (Zoback, 1989). A recent change from a normal faulting to a strike-slip faulting stress regime is indicated by the crosscutting striae on faults in basalts the dominantly strike-slip earthquake focal mechanisms and

Assessment of brain activities during an emotional stress state using fMRI

International Nuclear Information System (INIS)

Hayashi, Takuto; Mizuno-Matsumoto, Yuko; Kawasaki, Aika; Kato, Makoto; Murata, Tsutomu

2011-01-01

We investigated cerebrum activation using functional magnetic resonance imaging during a mental stress state. Thirty-four healthy adults participated. Before the experiment, we assessed their stress states using the Stress Self-rating Scale and divided the participants into Stress and Non-stress groups. The experiment consisted of 6 trials. Each trial consisted of a 20-s block of emotional audio-visual stimuli (4-s stimulation x 5 slides) and a fixation point. These processes were performed 3 times continuously (Relaxed, Pleasant, Unpleasant stimuli) in a random order. These results showed that the Non-stress group indicated activation of the amygdala and hippocampus in the Pleasant and Unpleasant stimuli while the Stress group indicated activation of the hippocampus in Pleasant stimuli, and the amygdala and hippocampus in Unpleasant stimuli. These findings suggested that the mental stress state engages the reduction of emotional processing. Also, the responsiveness of the memory system remained during and after the emotional stress state. (author)

Stress responses during aerobic exercise in relation to motivational dominance and state.

Science.gov (United States)

Thatcher, Joanne; Kuroda, Yusuke; Legrand, Fabien D; Thatcher, Rhys

2011-02-01

We examined the hypothesis that congruence between motivational dominance and state results in optimal psychological responses and performance during exercise. Twenty participants (10 telic dominant and 10 paratelic dominant) rated their stress at 5 min intervals as they cycled on an ergometer at gas exchange threshold for 30 min in both telic and paratelic state manipulated conditions. Participants then performed a test to exhaustion at a resistance equivalent to 110% of VO(2max). The hypothesized interaction between condition and dominance was significant for internal tension stress, as paratelic dominants were more stressed than telic dominants when exercising in the telic state and telic dominants were more stressed than paratelic dominants when exercising in the paratelic state. Similarly, the condition × dominance interaction for internal stress discrepancy was significant, as paratelic dominants reported greater internal stress discrepancy exercising in the telic compared with the paratelic state. Findings are discussed in relation to the application of reversal theory for understanding stress responses during aerobic exercise.

Daily Stress, Coping, and Negative and Positive Affect in Depression: Complex Trigger and Maintenance Patterns.

Science.gov (United States)

Dunkley, David M; Lewkowski, Maxim; Lee, Ihno A; Preacher, Kristopher J; Zuroff, David C; Berg, Jody-Lynn; Foley, J Elizabeth; Myhr, Gail; Westreich, Ruta

2017-05-01

Major depressive disorder is characterized by emotional dysfunction, but mood states in daily life are not well understood. This study examined complex explanatory models of daily stress and coping mechanisms that trigger and maintain daily negative affect and (lower) positive affect in depression. Sixty-three depressed patients completed perfectionism measures, and then completed daily questionnaires of stress appraisals, coping, and affect for 7 consecutive days. Multilevel structural equation modeling (MSEM) demonstrated that, across many stressors, when the typical individual with depression perceives more criticism than usual, he/she uses more avoidant coping and experiences higher event stress than usual, and this is connected to daily increases in negative affect as well as decreases in positive affect. In parallel, results showed that perceived control, less avoidant coping, and problem-focused coping commonly operate together when daily positive affect increases. MSEM also showed that avoidant coping tendencies and ongoing stress, in combination, explain why people with depression and higher self-critical perfectionism maintain daily negative affect and lower positive affect. These findings advance a richer and more detailed understanding of specific stress and coping patterns to target in order to more effectively accomplish the two predominant therapy goals of decreasing patients' distress and strengthening resilience. Copyright © 2016. Published by Elsevier Ltd.

Effects of Consolidation Stress State on Normally Consolidated Clay

DEFF Research Database (Denmark)

Lade, Poul V.

2000-01-01

The effect of consolidation stress state on the stress-strain and strength characteristics has been studied from experiments on undisturbed block samples of a natural, normally consolidated clay known as San Francisco Bay Mud. The results of experiments on K0-consolidated, hollow cylinder specimens...... and on isotropically consolidated, cubical specimens, both tested in triaxial compression and extension, clearly showed the influence of the undisturbed fabric as well as the effect of the initial consolidation stress states. While the K0-consolidated specimens appeared to retain their original fabric and exhibit...

PRESENTDAY STRESS STATE OF THE SHANXI TECTONIC BELT

Directory of Open Access Journals (Sweden)

Wang Kaiying

2012-01-01

Full Text Available The Shanxi tectonic belt is a historically earthquakeabundant area. For the majority of strong earthquakes in this area, the distribution of earthquake foci was controlled by the N–S oriented local structures on the tectonic belt. Studies of the present stress state of the Shanxi tectonic belt can contribute to the understanding of the relationship between strong earthquakes’ occurrence and their structural distribution and also facilitate assessments of regional seismic danger and determination of the regions wherein strong earthquakes may occur in future. Using the Cataclastic Analysis Method (CAM, we performed stress inversion based on the focal mechanism data of earthquakes which took place in the Shanxi tectonic belt from 1967 to 2010. Our results show that orientations of the maximum principal compressive stress axis of the Shanxi tectonic belt might have been variable before and after the 2001 Kunlun MS=8.1 strong earthquake, with two different superior trends of the NW–SE and NE–SW orientation in different periods. When the maximum principal compressive stress axis is oriented in the NE–SW direction, the pattern of the space distribution of the seismic events in the Shanxi tectonic belt shows a trend of their concentration in the N–S oriented tectonic segments. At the same time, the stress state is registered as horizontal shearing and horizontal extension in the N–S and NE–SW oriented local segments in turn. When the maximum principal compressive stress axis is NW–SE oriented, the stress state of the N–S and NE–SW oriented tectonic segments is primarily registered as horizontal shearing. Estimations of plunges of stress axes show that seismicity in the Shanxi belt  corresponds primarily to the activity of lowangle faults, and highangle stress sites are located in the NE–SW oriented extensional tectonic segments of the Shanxi belt. This indicates that the stress change of the Shanxi belt is

GASICA: Generic Automated Stress Induction and Control ApplicationDesign of an application for controlling the stress state

Directory of Open Access Journals (Sweden)

Benny Van Der Vijgh

2014-12-01

Full Text Available 1.In a multitude of research and therapy paradigms it is relevant to know, and desirably to control, the stress state of a patient or participant. Examples include research paradigms in which the stress state is the dependent or independent variable, or therapy paradigms where this state indicates the boundaries of the therapy. To our knowledge, no application currently exists that focuses specifically on the automated control of the stress state while at the same time being generic enough to be used in various therapy and research purposes. Therefore, we introduce GASICA, an application aimed at the automated control of the stress state in a multitude of therapy and research paradigms. The application consists of three components: a digital stressor game, a set of measurement devices and a feedback model. These three components form a closed loop (called a biocybernetic loop by Pope, Bogart, & Bartolome, 1995 and Fairclough, 2009 that continuously presents an acute psychological stressor, measures several physiological responses to this stressor, and adjusts the stressor intensity based on these measurements by means of the feedback model, hereby aiming to control the stress state. In this manner GASICA presents multidimensional and ecological valid stressors, whilst continuously in control of the form and intensity of the presented stressors, aiming at the automated control of the stress state. Furthermore, the application is designed as a modular open-source application to easily implement different therapy and research tasks using a high-level programming interface and configuration file, and allows for the addition of (existing measurement equipment, making it usable for various paradigms.

GASICA: generic automated stress induction and control application design of an application for controlling the stress state.

Science.gov (United States)

van der Vijgh, Benny; Beun, Robbert J; van Rood, Maarten; Werkhoven, Peter

2014-01-01

In a multitude of research and therapy paradigms it is relevant to know, and desirably to control, the stress state of a patient or participant. Examples include research paradigms in which the stress state is the dependent or independent variable, or therapy paradigms where this state indicates the boundaries of the therapy. To our knowledge, no application currently exists that focuses specifically on the automated control of the stress state while at the same time being generic enough to be used in various therapy and research purposes. Therefore, we introduce GASICA, an application aimed at the automated control of the stress state in a multitude of therapy and research paradigms. The application consists of three components: a digital stressor game, a set of measurement devices, and a feedback model. These three components form a closed loop (called a biocybernetic loop by Pope et al. (1995) and Fairclough (2009) that continuously presents an acute psychological stressor, measures several physiological responses to this stressor, and adjusts the stressor intensity based on these measurements by means of the feedback model, hereby aiming to control the stress state. In this manner GASICA presents multidimensional and ecological valid stressors, whilst continuously in control of the form and intensity of the presented stressors, aiming at the automated control of the stress state. Furthermore, the application is designed as a modular open-source application to easily implement different therapy and research tasks using a high-level programming interface and configuration file, and allows for the addition of (existing) measurement equipment, making it usable for various paradigms.

Response of single bacterial cells to stress gives rise to complex history dependence at the population level

Science.gov (United States)

Mathis, Roland; Ackermann, Martin

2016-01-01

Most bacteria live in ever-changing environments where periods of stress are common. One fundamental question is whether individual bacterial cells have an increased tolerance to stress if they recently have been exposed to lower levels of the same stressor. To address this question, we worked with the bacterium Caulobacter crescentus and asked whether exposure to a moderate concentration of sodium chloride would affect survival during later exposure to a higher concentration. We found that the effects measured at the population level depended in a surprising and complex way on the time interval between the two exposure events: The effect of the first exposure on survival of the second exposure was positive for some time intervals but negative for others. We hypothesized that the complex pattern of history dependence at the population level was a consequence of the responses of individual cells to sodium chloride that we observed: (i) exposure to moderate concentrations of sodium chloride caused delays in cell division and led to cell-cycle synchronization, and (ii) whether a bacterium would survive subsequent exposure to higher concentrations was dependent on the cell-cycle state. Using computational modeling, we demonstrated that indeed the combination of these two effects could explain the complex patterns of history dependence observed at the population level. Our insight into how the behavior of single cells scales up to processes at the population level provides a perspective on how organisms operate in dynamic environments with fluctuating stress exposure. PMID:26960998

Effect of insulin pump infusion on comprehensive stress state of ...

African Journals Online (AJOL)

Effect of insulin pump infusion on comprehensive stress state of patients with diabetic ketoacidosis. ... Relevant diabetes-associated serum indices, oxidative stress and stress hormone levels were compared between the ... from 32 Countries:.

Examination stress at unified state examination: student destabilization or success factor?

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Svetlana N. Kostromina

2017-01-01

Full Text Available The aim of the research is to clear up the influence of examination stress on the results of completing examination papers by students in the situation of trial General and Unified State Examinations, imitating the real-life environment of unified state certification of schoolchildren. The tasks of the research included determining the dynamics of psychophysiological stress indices at different examination stages, and evaluating additional factors (the subject in which the examination is held, the strategy of solving the variant, success of solving the task etc., influencing the quantity and quality of stress reactions at the examination.The novelty of the research is in the attempt to overcome the problem of confusing the notions of examination stress and examination anxiety, caused by metering the students’ state either before or after the examination. The technology of online monitoring the students’ psychophysiological state is used in the work, which makes it possible to eliminate a number of restrictions occurring during subjective evaluation of the state by the students themselves. Telemetric cardiorhythmography was chosen as the basic method. The method is based on a three-component model of extreme states with consequent domination of one of the three stress-reactive systems. A cardiointervalogramm was being registered in the research process in the online mode and underwent spectral analysis. The following indices of heart rate variability were recorded in order to determine stress reactions: the total power of the spectrum (TP, the spectrum power in low-frequency (LF and high-frequency (HF regions, and a vegetative balance index (relation of the spectrum powers in low-frequency and high-frequency regions (LF/HF. When the total power of the heart rate fell and, at the same time, the vegetative balance index rose, a conclusion was made of there being a stress reaction. Twenty-five students of an illustrious school were examined

Minimized state complexity of quantum-encoded cryptic processes

Science.gov (United States)

Riechers, Paul M.; Mahoney, John R.; Aghamohammadi, Cina; Crutchfield, James P.

2016-05-01

The predictive information required for proper trajectory sampling of a stochastic process can be more efficiently transmitted via a quantum channel than a classical one. This recent discovery allows quantum information processing to drastically reduce the memory necessary to simulate complex classical stochastic processes. It also points to a new perspective on the intrinsic complexity that nature must employ in generating the processes we observe. The quantum advantage increases with codeword length: the length of process sequences used in constructing the quantum communication scheme. In analogy with the classical complexity measure, statistical complexity, we use this reduced communication cost as an entropic measure of state complexity in the quantum representation. Previously difficult to compute, the quantum advantage is expressed here in closed form using spectral decomposition. This allows for efficient numerical computation of the quantum-reduced state complexity at all encoding lengths, including infinite. Additionally, it makes clear how finite-codeword reduction in state complexity is controlled by the classical process's cryptic order, and it allows asymptotic analysis of infinite-cryptic-order processes.

Profile of stress factors associated with mental disorders in children and adolescents referred for evaluation and treatment to the Free State Psychiatric Complex, 2007

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H Heckler

2012-05-01

Full Text Available Introduction. South African children and adolescents face serious challenges. Over the past decades children have been exposed to rapid and stressful changes in their environment, including increased crime and violence. Aim of study. The aim of the study was to determine the profile of stress factors leading to mental disorders in children and adolescents referred to the Child and Adolescent Unit at the Free State Psychiatric Complex, Bloemfontein, from January 2006 to December 2007. Methods. A total of 669 children (0 - 12 years and adolescents (13 - 18 years referred to the unit for evaluation and treatment were included in the study. Results. Thirty per cent were diagnosed with attention deficit and disruptive behaviour disorders, followed by major depressive disorders (22.7%, anxiety disorders (18.5%, conduct disorders (16.1%, mild mental retardation (15.7%, adjustment disorders (9.6%, elimination disorders (8.8%, developmental disorders (7.6% and bereavement (7.0%. Social stressors were identified in 64.1% of participants, and psychological stressors in 19%. Conclusions. Stress plays an important role in the lives of children and adolescents, which could lead to emotional problems if not well managed. The functioning of children and adolescents should be monitored continuously. Schools are in a favourable position to identify stressors affecting children and adolescents. Educators therefore need training and opportunities to consult on mental health matters. Furthermore, religious organisations should be enlisted to identify stressors manifesting as spiritual dysfunction. School health services can play a role in the recognition of biological stressors such as epilepsy, pregnancy, enuresis, illness, speech problems and sensory dysfunction.

State Complexity of Testing Divisibility

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Emilie Charlier

2010-08-01

Full Text Available Under some mild assumptions, we study the state complexity of the trim minimal automaton accepting the greedy representations of the multiples of m >= 2 for a wide class of linear numeration systems. As an example, the number of states of the trim minimal automaton accepting the greedy representations of the multiples of m in the Fibonacci system is exactly 2m^2.

Stress state dependence of transient irradiation creep in 20% cold worked 316 stainless steel

International Nuclear Information System (INIS)

Foster, J.P.; Gilbert, E.R.

1998-01-01

Irradiation creep tests were performed in fast reactors using the stress states of uniaxial tension, biaxial tension, bending and torsion. In order to compare the saturated transient strain irradiation creep component, the test data were converted to equivalent strain and equivalent stress. The saturated transient irradiation creep component was observed to depend on the stress state. The highest value was exhibited by the uniaxial tension stress state, and the lowest by the torsion stress state. The biaxial tension and bending stress state transient component values were intermediate. This behavior appears to be related to the dislocation or microscopic substructure resulting from fabrication processing and the applied stress direction. (orig.)

Children with medical complexity: a scoping review of interventions to support caregiver stress.

Science.gov (United States)

Edelstein, H; Schippke, J; Sheffe, S; Kingsnorth, S

2017-05-01

Caring for children with chronic and complex medical needs places extraordinary stress on parents and other family members. A scoping review was undertaken to identify and describe the full range of current interventions for reducing caregiver stress. Applying a broad definition of caregiver stress, a systematic search of three scientific databases (CINAHL, Embase and Ovid Medline), a general internet search and hand searching of key peer-reviewed articles were conducted. Inclusion criteria were as follows: (i) published in English between 2004-2016; (ii) focused on familial caregivers, defined as parents, siblings or extended family; (iii) targeted children/youth with medical complexity between the ages of 1-24 years; and (iv) described an intervention and impact on caregiver stress. Data on type of intervention, study design and methods, measures and overall findings were extracted. Forty-nine studies were included from a list of 22 339 unique titles. Six domains of interventions were found: care coordination models (n = 23); respite care (n = 8); telemedicine (n = 5); peer and emotional support (n = 6); insurance and employment benefits (n = 4); and health and related supports (n = 3). Across studies, there was a wide variety of designs, outcomes and measures used. Positive findings of reductions in caregiver stress were noted within an emerging body of evidence on effective interventions for families of children with medical complexity. A commonality across domains was a significant focus on streamlining services and reducing the burden of care related to varied pressures experienced, including time, finances, care needs and service access, among others. There was non-conclusive evidence however around which of the six identified intervention domains or combination thereof are most effective for reducing stress. These promising findings demonstrate that stress reduction is possible with the right support and that multiple

Measurements of the state of stress in deep drill holes

International Nuclear Information System (INIS)

Vaeaetaeinen, A.; Saerkkae, P.

1985-05-01

The state of stress in rock is one of the most important parameters in the safe planning of stable underground openings in rock. At the same time, it is very difficult to be determined from a great distance. The common methods for the determination of state of stress in bedrock are usually not able to do this from a distance over 30 m. This work is a survey on rock stress determination methods usable in deep, over 500 m, drill holes. It also contains a recommendation for a method to determine the state of stress in Lavia test hole. The presented recommendation for the measurement of the state of stress contains an estimation on the working time for the measurement as well as the amount and location of the measuring points. The examination of the methods has been concentrated on three methods, hydraulic fracturing, overcoring by Vattenfall and differential strain analysis. Theoretical background of these methods has been analyzed. A special interest has been laid on the fundamental assumptions of different methods and their influence on the reliability of the results and the interpretation of the state of stress. The comparison of the methods has been made by literature and user interviews. Equipment and personnel needed, and way of measurement are described for the methods. The parameters measured and their possible sources of errors are described, too, as well as the fundamental assumptions and potential difficulties in the measurement. The organizations in Scandinavia performing measurements and their abilities to do measurements and interpretation are presented. Readiness to interpretation in Finland is described shortly

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.

Directory of Open Access Journals (Sweden)

Jae Ho Seo

2016-07-01

Full Text Available Mitochondria must buffer the risk of proteotoxic stress to preserve bioenergetics, but the role of these mechanisms in disease is poorly understood. Using a proteomics screen, we now show that the mitochondrial unfoldase-peptidase complex ClpXP associates with the oncoprotein survivin and the respiratory chain Complex II subunit succinate dehydrogenase B (SDHB in mitochondria of tumor cells. Knockdown of ClpXP subunits ClpP or ClpX induces the accumulation of misfolded SDHB, impairing oxidative phosphorylation and ATP production while activating "stress" signals of 5' adenosine monophosphate-activated protein kinase (AMPK phosphorylation and autophagy. Deregulated mitochondrial respiration induced by ClpXP targeting causes oxidative stress, which in turn reduces tumor cell proliferation, suppresses cell motility, and abolishes metastatic dissemination in vivo. ClpP is universally overexpressed in primary and metastatic human cancer, correlating with shortened patient survival. Therefore, tumors exploit ClpXP-directed proteostasis to maintain mitochondrial bioenergetics, buffer oxidative stress, and enable metastatic competence. This pathway may provide a "drugable" therapeutic target in cancer.

Complex posttraumatic stress disorder: an exploratory investigation of PTSD and DES NOS among Dutch war veterans

NARCIS (Netherlands)

Jongedijk, R. A.; Carlier, I. V.; Schreuder, B. J.; Gersons, B. P.

1996-01-01

The recently developed concept Disorder of Extreme Stress Not Otherwise Specified (DES NOS) or complex posttraumatic stress disorder (complex PTSD) is designed to encompass long-standing symptoms not present in PTSD. An exploratory investigation of PTSD and DES NOS was performed with the Structured

Weaving and neural complexity in symmetric quantum states

Science.gov (United States)

Susa, Cristian E.; Girolami, Davide

2018-04-01

We study the behaviour of two different measures of the complexity of multipartite correlation patterns, weaving and neural complexity, for symmetric quantum states. Weaving is the weighted sum of genuine multipartite correlations of any order, where the weights are proportional to the correlation order. The neural complexity, originally introduced to characterize correlation patterns in classical neural networks, is here extended to the quantum scenario. We derive closed formulas of the two quantities for GHZ states mixed with white noise.

Stressful life events and psychological dysfunction in complex regional pain syndrome type I

NARCIS (Netherlands)

Geertzen, JHB; de Bruijn-Kofman, AT; de Bruijn, HP; van de Wiel, HBM; Dijkstra, PU

Objective: To determine to what extent stressful life events and psychological dysfunction play a role in the pathogenesis of Complex Regional Pain Syndrome type I (CRPS). Design: A comparative study between a CRPS group and a control group. Stressful life events and psychological dysfunction

Role of multiaxial stress state in the hydrogen-assisted rolling-contact fatigue in bearings for wind turbines

Directory of Open Access Journals (Sweden)

J. Toribio

2015-07-01

Full Text Available Offshore wind turbines often involve important engineering challenges such as the improvement of hydrogen embrittlement resistance of the turbine bearings. These elements frequently suffer the so-called phenomenon of hydrogen-assisted rolling-contact fatigue (HA-RCF as a consequence of the synergic action of the surrounding harsh environment (the lubricant supplying hydrogen to the material and the cyclic multiaxial stress state caused by in-service mechanical loading. Thus the complex phenomenon could be classified as hydrogen-assisted rolling-contact multiaxial fatigue (HA-RC-MF. This paper analyses, from the mechanical and the chemical points of view, the so-called ball-on-rod test, widely used to evaluate the hydrogen embrittlement susceptibility of turbine bearings. Both the stress-strain states and the steady-state hydrogen concentration distribution are studied, so that a better elucidation can be obtained of the potential fracture places where the hydrogen could be more harmful and, consequently, where the turbine bearings could fail during their life in service.

Stressed Out: How Stress Develops and How to Cope with it

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Mortillaro Marcello

2014-05-01

Full Text Available Our experience of stress depends on how we evaluate the circumstances impacting our individual well-being. In principle, any event can be a stressor. Certain events can produce complex emotional states, such as a mixture of anger and worry. If such states are prolonged, they can lead to stress. Stress can be identified by means of such expressive components as facial expression and signs of stress in the voice. Indeed, the voice is particularly sensitive to stress and is frequently used to measure stress levels. Coping strategies differ from person to person and are not mutually exclusive. Often, people use multiple strategies at the same time. Not all of these strategies are good for individual well-being or favor a cooperation-based work culture. To avoid employee burnout, companies should keep an eye on the stress load of their employees and develop trainings to increase emotional competences and improve constructive stress management.

Effect of stress-state and spacing on voids in a shear-field

DEFF Research Database (Denmark)

Tvergaard, Viggo

2012-01-01

in the overall average stress state can be prescribed. This also allows for studies of the effect of different initial void spacing in the two in-plane coordinate directions. The stress states considered are essentially simple shear, with various levels of tensile stresses or compressive stresses superposed, i.......e. low positive stress triaxiality or even negative stress triaxiality. For high aspect ratio unit cells a clear localization band is found inside the cell, which actually represents several parallel bands, due to periodicity. In the materials represented by a low aspect ratio unit cell localization...

Toward a Definition of Complexity for Quantum Field Theory States.

Science.gov (United States)

Chapman, Shira; Heller, Michal P; Marrochio, Hugo; Pastawski, Fernando

2018-03-23

We investigate notions of complexity of states in continuous many-body quantum systems. We focus on Gaussian states which include ground states of free quantum field theories and their approximations encountered in the context of the continuous version of the multiscale entanglement renormalization ansatz. Our proposal for quantifying state complexity is based on the Fubini-Study metric. It leads to counting the number of applications of each gate (infinitesimal generator) in the transformation, subject to a state-dependent metric. We minimize the defined complexity with respect to momentum-preserving quadratic generators which form su(1,1) algebras. On the manifold of Gaussian states generated by these operations, the Fubini-Study metric factorizes into hyperbolic planes with minimal complexity circuits reducing to known geodesics. Despite working with quantum field theories far outside the regime where Einstein gravity duals exist, we find striking similarities between our results and those of holographic complexity proposals.

Toward a Definition of Complexity for Quantum Field Theory States

Science.gov (United States)

Chapman, Shira; Heller, Michal P.; Marrochio, Hugo; Pastawski, Fernando

2018-03-01

We investigate notions of complexity of states in continuous many-body quantum systems. We focus on Gaussian states which include ground states of free quantum field theories and their approximations encountered in the context of the continuous version of the multiscale entanglement renormalization ansatz. Our proposal for quantifying state complexity is based on the Fubini-Study metric. It leads to counting the number of applications of each gate (infinitesimal generator) in the transformation, subject to a state-dependent metric. We minimize the defined complexity with respect to momentum-preserving quadratic generators which form s u (1 ,1 ) algebras. On the manifold of Gaussian states generated by these operations, the Fubini-Study metric factorizes into hyperbolic planes with minimal complexity circuits reducing to known geodesics. Despite working with quantum field theories far outside the regime where Einstein gravity duals exist, we find striking similarities between our results and those of holographic complexity proposals.

[Study on the relationship between occupational stress and psychological health state among oil workers].

Science.gov (United States)

Liu, Jiwen; Wang, Zhiming; Wang, Mianzhen; Lan, Yajia; Zhan, Chenglie; Zhao, Xiaoguo

2002-02-01

To study the relationship between occupational stress and psychological health state among oil workers. 1,230 oil workers in 122 work types of oil industry were selected and written occupational stress questionary(OSQ) and symptom check list (SCL-90). Petroleum workers' psychological health states were poor with increasing occupational stress degree. The scores in physical symptoms(1.87 +/- 0.80, 1.72 +/- 0.70), depression(1.74 +/- 0.76, 1.62 +/- 0.67), horror(1.48 +/- 0.65, 1.39 +/- 0.55) in the high and medium stress group were obviously higher than those in low stress group(1.55 +/- 0.61, 1.43 +/- 0.54, 1.28 +/- 0.46, respectively, P < 0.05). The score of mood state in the high and medium stress group was obviously higher than that in low stress group(P < 0.05). Psychological health states and mood state in the petroleum workers with short service length are significantly poorer than that with long service length(P < 0.01). Occupational stress should affect psychological health state of petroleum workers.

Untangling complex networks: risk minimization in financial markets through accessible spin glass ground states.

Science.gov (United States)

Lisewski, Andreas Martin; Lichtarge, Olivier

2010-08-15

Recurrent international financial crises inflict significant damage to societies and stress the need for mechanisms or strategies to control risk and tamper market uncertainties. Unfortunately, the complex network of market interactions often confounds rational approaches to optimize financial risks. Here we show that investors can overcome this complexity and globally minimize risk in portfolio models for any given expected return, provided the relative margin requirement remains below a critical, empirically measurable value. In practice, for markets with centrally regulated margin requirements, a rational stabilization strategy would be keeping margins small enough. This result follows from ground states of the random field spin glass Ising model that can be calculated exactly through convex optimization when relative spin coupling is limited by the norm of the network's Laplacian matrix. In that regime, this novel approach is robust to noise in empirical data and may be also broadly relevant to complex networks with frustrated interactions that are studied throughout scientific fields.

Untangling complex networks: Risk minimization in financial markets through accessible spin glass ground states

Science.gov (United States)

Lisewski, Andreas Martin; Lichtarge, Olivier

2010-08-01

Recurrent international financial crises inflict significant damage to societies and stress the need for mechanisms or strategies to control risk and tamper market uncertainties. Unfortunately, the complex network of market interactions often confounds rational approaches to optimize financial risks. Here we show that investors can overcome this complexity and globally minimize risk in portfolio models for any given expected return, provided the margin requirement remains below a critical, empirically measurable value. In practice, for markets with centrally regulated margin requirements, a rational stabilization strategy would be keeping margins small enough. This result follows from ground states of the random field spin glass Ising model that can be calculated exactly through convex optimization when relative spin coupling is limited by the norm of the network’s Laplacian matrix. In that regime, this novel approach is robust to noise in empirical data and may be also broadly relevant to complex networks with frustrated interactions that are studied throughout scientific fields.

RESEARCH OF THE STRESS STATE OF A MODIFIED IN-SITU CONCRETE

Directory of Open Access Journals (Sweden)

D. V. Rudenko

2016-12-01

Full Text Available Purpose. The article focuses on investigation of the stress state of a modified in-situ concrete of natural hardening. Methodology. To achieve the aim, the research of the microstructure of the modified cement matrix of concrete, as well as the mechanism of structure formation of modified concrete with natural hardening was conducted; the methods for reliable evaluation of concrete strength were defined. Findings. The development of internal stresses affects the properties of concretedifferently. With an increase in temperature-shrinkage deformations in time and, thus, with increasing structural stresses in the cement sheath around the grains of the filler two opposite processes may develop: zone of plastic flow or cracking. Originality. It was established that the structural features complex of the modified concrete when the load transfer leads to the formation of extensive zones of prefracture which is able to absorb a significant amount of elastic strain energy that provides the design deformation properties of the concrete for special purposes. Ideas about the definition of the criteria of cracking modified concrete, hardening under natural conditions had further development. Practical value. The resulting equations allow to solve the problem about the minimum level of structural stress in monolithic concrete in a saturated large placeholder, as well as to assess the influence of structural stresses on the properties of concrete. In normal concrete with a relatively thin cement sheath at temperature-shrinkage deformations, high tangential and low radial tension occur. In vivo, this stress is higher as a result of higher values of Δε(τ, which is not observed in the modified concrete. In the modified concretes only tangential stresses are the greatest danger to structures. The change of shrinkage stress with time is straightforward. The total temperature-shrinkage deformations have a sawtooth graph. For modified concrete the amplitude is 48

Perception of effects of auricular acupuncture on stress in receptionists of a hospital complex

Directory of Open Access Journals (Sweden)

Alessandra Faleiros Silveira

2018-01-01

Full Text Available Background and objectives: The stress is a reaction of organism that involves physical and psychological components and can tease changes in homeostasis of human body. This survey has intent to know the possible benefits of acupuncture on stress reduction, with the objective to evaluate the perceptions on levels of stress before and after eight weeks of an intervention of auricular acupuncture in receptionists of complex hospital. Methods: Participated in these study 24 receptionists of four units of a complex hospital situated in a municipality from the interior of Sao Paulo estate, which had an intervention in eight weeks with auricular acupuncture. To evaluate the perception of stress, they wrote their impressions about stress during the weekly meetings in order to change the needles. Results: According to the perception of most of the majority, the auricular acupuncture demonstrated benefits and changes in the way to deal with stressful situations day by day. They realized themselves calmer, with emotional control, presenting reduction of premenstrual syndrome symptoms and physical and mental well-being; however, for three participants the auricular acupuncture demonstrated few or none difference in reduction of stress. Conclusion: The auricular acupuncture intervention in this study demonstrate benefits on the reduction levels of stress, evidenced changes, not only in reduction stress, as also the perception of health in general.

Computer modeling of the stress-strain state of welded construction

Science.gov (United States)

Nurguzhin, Marat; Danenova, Gulmira; Akhmetzhanov, Talgat

2017-11-01

At the present time the maintenance of the welded construction serviceability over normative service life is provided by the maintenance system on the basis of the guiding documents according to the concept of "fail safe". However, technology factors relating to welding such as high residual stresses and significant plastic strains are not considered in the guiding documents. The design procedure of the stressed-strained state of welded constructions is suggested in the paper. The procedure investigates welded constructions during welding and the external load using the program ANSYS. In this paper, the model of influence of the residual stress strain state on the factor of stress intensity is proposed. The calculation method of the residual stressed-strained state (SSS) taking into account the phase transition is developed by the authors. Melting and hardening of a plate material during heating and cooling is considered. The thermomechanical problem of heating a plate by a stationary heat source is solved. The setup of the heating spot center on distance (190 mm) from the crack top in a direction of its propagation leads to the fact that the value of total factor of stress intensity will considerably decrease under action of the specified residual compressing stresses. It can lower the speed of the crack propagation to zero. The suggested method of survivability maintenance can be applied during operation with the purpose of increasing the service life of metal constructions up to running repair of technological machines.

ATF1 Modulates the Heat Shock Response by Regulating the Stress-Inducible Heat Shock Factor 1 Transcription Complex

Science.gov (United States)

Takii, Ryosuke; Fujimoto, Mitsuaki; Tan, Ke; Takaki, Eiichi; Hayashida, Naoki; Nakato, Ryuichiro; Shirahige, Katsuhiko

2014-01-01

The heat shock response is an evolutionally conserved adaptive response to high temperatures that controls proteostasis capacity and is regulated mainly by an ancient heat shock factor (HSF). However, the regulation of target genes by the stress-inducible HSF1 transcription complex has not yet been examined in detail in mammalian cells. In the present study, we demonstrated that HSF1 interacted with members of the ATF1/CREB family involved in metabolic homeostasis and recruited them on the HSP70 promoter in response to heat shock. The HSF1 transcription complex, including the chromatin-remodeling factor BRG1 and lysine acetyltransferases p300 and CREB-binding protein (CBP), was formed in a manner that was dependent on the phosphorylation of ATF1. ATF1-BRG1 promoted the establishment of an active chromatin state and HSP70 expression during heat shock, whereas ATF1-p300/CBP accelerated the shutdown of HSF1 DNA-binding activity during recovery from acute stress, possibly through the acetylation of HSF1. Furthermore, ATF1 markedly affected the resistance to heat shock. These results revealed the unanticipated complexity of the primitive heat shock response mechanism, which is connected to metabolic adaptation. PMID:25312646

Operational State Complexity of Deterministic Unranked Tree Automata

Directory of Open Access Journals (Sweden)

Xiaoxue Piao

2010-08-01

Full Text Available We consider the state complexity of basic operations on tree languages recognized by deterministic unranked tree automata. For the operations of union and intersection the upper and lower bounds of both weakly and strongly deterministic tree automata are obtained. For tree concatenation we establish a tight upper bound that is of a different order than the known state complexity of concatenation of regular string languages. We show that (n+1 ( (m+12^n-2^(n-1 -1 vertical states are sufficient, and necessary in the worst case, to recognize the concatenation of tree languages recognized by (strongly or weakly deterministic automata with, respectively, m and n vertical states.

The influence of the anisotropic stress state on the intermediate strain properties of granular material

KAUST Repository

Goudarzy, M.

2017-07-20

This paper shows the effect of anisotropic stress state on intermediate strain properties of cylindrical samples containing spherical glass particles. Tests were carried out with the modified resonant column device available at Ruhr-Universität Bochum. Dry samples were subjected to two anisotropic stress states: (a) cell pressure, σ′h, constant and vertical stress, σ′v, increased (stress state GB-I) and (b) σ′v/σ′h equal to 2 (stress state GB-II). The experimental results revealed that the effect of stress state GB-II on the modulus and damping ratio was more significant and obvious than stress state GB-I. The effect of the anisotropic stress state was explained through the impact of confining pressure and anisotropic stress components on the stiffness and damping ratio. The results showed that: (a) G(γ) increased, η(γ) decreased and their strain non-linearity decreased with an increase in the confining pressure component σ′vσ′h; (b) G(γ) decreased, η(γ) increased and their strain non-linearity increased with an increase in the anisotropic stress component, σ′v/σ′h. The analysis of results revealed that reference shear strain was also affected by anisotropic stress state. Therefore, an empirical relationship was developed to predict the reference shear strain, as a function of confining pressure and anisotropic stress components. Additionally, the damping ratio was written as a function of the minimum damping ratio and the reference shear strain.

Thermal stress state of cryogenic HP vessels under freezing and pressurization

International Nuclear Information System (INIS)

Tsybenko, A.S.; Kuranov, B.A.; Chepurnoj, A.D.; Shaposhnikov, V.A.; Krishchuk, N.G.

1986-01-01

A mathematical model is developed for thermomechanical processes in cryogenic HP vessels under freezing either by liquid and (or) gaseous cryogen and under pressurization. Equations of nonlinear nonstationary thermal conductivity and nonisothermal thermoelastoplasticity are used for the case of the theory off low with isotropic hardening. Semiempiricaldependences of nonstationary heat exchange for gaseous medium, experimental curves of cryogenic liquid boiling, mass exchange relationships are allowed for when formulating boundary conditions. The mathematical modelis realized on the basi of the finite element method in the form of highly automated program complex TERSOD (heat resistanceof vessels), oriented for computer of the Unified System. Heat and stress-strained states for three constructions of vessels are thoroughly studied under different conditions of gaseous, liquid and combined freezing with subsequent pressurization

Stress and Strain State Analysis of Defective Pipeline Portion

Science.gov (United States)

Burkov, P. V.; Burkova, S. P.; Knaub, S. A.

2015-09-01

The paper presents computer simulation results of the pipeline having defects in a welded joint. Autodesk Inventor software is used for simulation of the stress and strain state of the pipeline. Places of the possible failure and stress concentrators are predicted on the defective portion of the pipeline.

Investigation of the Residual Stress State in an Epoxy Based Specimen

DEFF Research Database (Denmark)

Baran, Ismet; Jakobsen, Johnny; Andreasen, Jens Henrik

2015-01-01

Abstract. Process induced residual stresses may play an important role under service loading conditions for fiber reinforced composite. They may initiate premature cracks and alter the internal stress level. Therefore, the developed numerical models have to be validated with the experimental...... observations. In the present work, the formation of the residual stresses/strains are captured from experimental measurements and numerical models. An epoxy/steel based sample configuration is considered which creates an in-plane biaxial stress state during curing of the resin. A hole drilling process...... material models, i.e. cure kinetics, elastic modulus, CTE, chemical shrinkage, etc. together with the drilling process using the finite element method. The measured and predicted in-plane residual strain states are compared for the epoxy/metal biaxial stress specimen....

Influence of psychoemotional stress on the functional state of the neuromuscular system and the efficiency of sensorimotor activity of highly skilled athletes

Directory of Open Access Journals (Sweden)

Svitlana Fedorchuk

2017-08-01

Full Text Available Purpose: assessment of the influence of the level of psychoemotional stress and the effectiveness of mental self-regulation on the functional state of the neuromuscular system and the effectiveness of the sensorimotor activity of highly skilled athletes specializing in complex co-ordination sports (on the example of diving. Material & Methods: study involved 14 high-class athletes (master of sport, international master of sport, honored master of sports at the age of 15–30 years. To determine the psychophysiological properties of the nervous system of athletes, the diagnostic complex "Diagnost-1" are used. Electroneuromyography was performed on the neurodiagnostic complex "Nicolet Viking Select". For a differentiated assessment of the level of stress, the emotional state of the respondents and also for assessing the effectiveness of mental self-regulation, a technique to select colors was used. Result: interrelation between the effectiveness of mental self-regulation and adaptability, the intensity of existing stress, emotional stability and vegetative balance with electroneuromyographic characteristics, strength and functional mobility of nervous processes, the accuracy of reaction to a moving object and the ratio of the reactions of lead and lag, the efficiency of sensorimotor activity are identified. Conclusion: revealed interrelation of the effectiveness of mental self-regulation and adaptability, intensity of existing stress, emotional stability and vegetative balance with typological properties of the higher parts of the central nervous system and electroneuromyographic characteristics of athletes can have prognostic value and be used to optimize the sports development of promising young people.

State of charge estimation for lithium-ion pouch batteries based on stress measurement

International Nuclear Information System (INIS)

Dai, Haifeng; Yu, Chenchen; Wei, Xuezhe; Sun, Zechang

2017-01-01

State of charge (SOC) estimation is one of the important tasks of battery management system (BMS). Being different from other researches, a novel method of SOC estimation for pouch lithium-ion battery cells based on stress measurement is proposed. With a comprehensive experimental study, we find that, the stress of the battery during charge/discharge is composed of the static stress and the dynamic stress. The static stress, which is the measured stress in equilibrium state, corresponds to SOC, this phenomenon facilitates the design of our stress-based SOC estimation. The dynamic stress, on the other hand, is influenced by multiple factors including charge accumulation or depletion, current and historical operation, thus a multiple regression model of the dynamic stress is established. Based on the relationship between static stress and SOC, as well as the dynamic stress modeling, the SOC estimation method is founded. Experimental results show that the stress-based method performs well with a good accuracy, and this method offers a novel perspective for SOC estimation. - Highlights: • A State of Charge estimator based on stress measurement is proposed. • The stress during charge and discharge is investigated with comprehensive experiments. • Effects of SOC, current, and operation history on battery stress are well studied. • A multiple regression model of the dynamic stress is established.

Remaining stress-state and strain-energy in tempered glass fragments

DEFF Research Database (Denmark)

Nielsen, Jens Henrik

2016-01-01

to the fragmentation process and some authors e.g. Barsom (J Am Ceram Soc 51(2):75, 1968), Gulati (Glass processing days, Tamglass Engineering Oy, Tampere, 1997), Warren (Fractography of glasses and ceramics IV, Alfred University, Alfred, 2001) and Tandon and Glass (Fracture mechanics of ceramics—active materials......When tempered glass breaks, it shatters into relatively small pieces depending on the residual stress state in the glass. This has been known for centuries and is currently used in standards for classifying whether a piece of glass is tempered or not. However, the process of fragmentation...... is complex and only a few, relatively simple, models have been suggested for predicting the fragment size. The full theoretical explanation is still to be found and this work aims at providing another brick to the puzzle. The strain-energy present in tempered glass is obviously contributing...

Stress Intensity Factor for Interface Cracks in Bimaterials Using Complex Variable Meshless Manifold Method

Directory of Open Access Journals (Sweden)

Hongfen Gao

2014-01-01

Full Text Available This paper describes the application of the complex variable meshless manifold method (CVMMM to stress intensity factor analyses of structures containing interface cracks between dissimilar materials. A discontinuous function and the near-tip asymptotic displacement functions are added to the CVMMM approximation using the framework of complex variable moving least-squares (CVMLS approximation. This enables the domain to be modeled by CVMMM without explicitly meshing the crack surfaces. The enriched crack-tip functions are chosen as those that span the asymptotic displacement fields for an interfacial crack. The complex stress intensity factors for bimaterial interfacial cracks were numerically evaluated using the method. Good agreement between the numerical results and the reference solutions for benchmark interfacial crack problems is realized.

Oxidatively generated DNA/RNA damage in psychological stress states

DEFF Research Database (Denmark)

Jørgensen, Anders

2013-01-01

age-related somatic disorders. The overall aim of the PhD project was to investigate the relation between psychopathology, psychological stress, stress hormone secretion and oxidatively generated DNA and RNA damage, as measured by the urinary excretion of markers of whole-body DNA/RNA oxidation (8...... between the 24 h urinary cortisol excretion and the excretion of 8-oxodG/8-oxoGuo, determined in the same samples. Collectively, the studies could not confirm an association between psychological stress and oxidative stress on nucleic acids. Systemic oxidatively generated DNA/RNA damage was increased......Both non-pathological psychological stress states and mental disorders are associated with molecular, cellular and epidemiological signs of accelerated aging. Oxidative stress on nucleic acids is a critical component of cellular and organismal aging, and a suggested pathogenic mechanism in several...

Measured resolved shear stresses and Bishop-Hill stress states in individual grains of austenitic stainless steel

DEFF Research Database (Denmark)

Juul, Nicolai Ytterdal; Oddershede, Jette; Beaudoin, Armand

2017-01-01

somewhat from the theoretical expectation. These deviations are found to originate from a larger tensile stress component than in the theoretical Bishop-Hill stress states and to be associated also with deviations from axisymmetric plastic strain. This conclusion was supported by finite-element crystal...

Selective buckling via states of self-stress in topological metamaterials.

Science.gov (United States)

Paulose, Jayson; Meeussen, Anne S; Vitelli, Vincenzo

2015-06-23

States of self-stress--tensions and compressions of structural elements that result in zero net forces--play an important role in determining the load-bearing ability of structures ranging from bridges to metamaterials with tunable mechanical properties. We exploit a class of recently introduced states of self-stress analogous to topological quantum states to sculpt localized buckling regions in the interior of periodic cellular metamaterials. Although the topological states of self-stress arise in the linear response of an idealized mechanical frame of harmonic springs connected by freely hinged joints, they leave a distinct signature in the nonlinear buckling behavior of a cellular material built out of elastic beams with rigid joints. The salient feature of these localized buckling regions is that they are indistinguishable from their surroundings as far as material parameters or connectivity of their constituent elements are concerned. Furthermore, they are robust against a wide range of structural perturbations. We demonstrate the effectiveness of this topological design through analytical and numerical calculations as well as buckling experiments performed on two- and three-dimensional metamaterials built out of stacked kagome lattices.

Numerical study on core damage and interpretation of in situ state of stress

Energy Technology Data Exchange (ETDEWEB)

Hakala, M. [Gridpoint Finland Oy (Finland)

1999-06-01

Core disking is a phenomenon where a diamond cored core sample will be sliced when released from a stressed host rock. Ring disking is a similar phenomenon which takes place during overcoring with a pilot hole. Because of the uniform shape and spacing of disk fracturing, it has the potential to be used for estimating the in situ state of stress. If this is feasible, it could be used in high stress states where the traditional stress measuring techniques are not valid or even possible. In this work the both the core disking and ring disking phenomena were studied based on the elastic bottom hole stress application developed and a series of fracture growth stability simulations. The results-showed that both phenomena are very complicated and site specific, but the spacing, shape, extent and initiation point are clearly stress state dependent. Throughout the work, guidelines for the in situ stress field interpretation method were developed and implemented for the borehole aligned orthogonal stress field and Poisson`s ratio of 0.25. Based on this study, the in situ state of stress can be estimated with acceptable accuracy if information on both core disking and ring disking is available. On the other hand, as an indirect method, there are no reasons to use it if direct measurements can be used. (orig.) 35 refs.

Numerical study on core damage and interpretation of in situ state of stress

International Nuclear Information System (INIS)

Hakala, M.

1999-06-01

Core disking is a phenomenon where a diamond cored core sample will be sliced when released from a stressed host rock. Ring disking is a similar phenomenon which takes place during overcoring with a pilot hole. Because of the uniform shape and spacing of disk fracturing, it has the potential to be used for estimating the in situ state of stress. If this is feasible, it could be used in high stress states where the traditional stress measuring techniques are not valid or even possible. In this work the both the core disking and ring disking phenomena were studied based on the elastic bottom hole stress application developed and a series of fracture growth stability simulations. The results-showed that both phenomena are very complicated and site specific, but the spacing, shape, extent and initiation point are clearly stress state dependent. Throughout the work, guidelines for the in situ stress field interpretation method were developed and implemented for the borehole aligned orthogonal stress field and Poisson's ratio of 0.25. Based on this study, the in situ state of stress can be estimated with acceptable accuracy if information on both core disking and ring disking is available. On the other hand, as an indirect method, there are no reasons to use it if direct measurements can be used. (orig.)

Application of laser interferometry for assessment of surface residual stress by determination of stress-free state

International Nuclear Information System (INIS)

Kim, Dong Won; Kwon, Dong Il; Lee, Nak Kyu; Choi, Tae Hoon; Na, Kyoung Hoan

2003-01-01

The total relaxed stress in annealing and the thermal strain/stress were obtained from the identification of the residual stress-free state using Electronic Speckle Pattern Interferometry (ESPI). The residual stress fields in case of both single and film/substrate systems were modeled using the thermo-elastic theory and the relationship between relaxed stresses and displacements. We mapped the surface residual stress fields on the indented bulk Cu and the 0.5 μm Au film by ESPI. In indented Cu, the normal and shear residual stress are distributed over -1.7 GPa to 700 MPa and -800 GPa to 600 MPa respectively around the indented point and in deposited Au film on Si wafer, the tensile residual stress is uniformly distributed on the Au film from 500 MPa to 800 MPa. Also we measured the residual stress by the X-Ray Diffractometer (XRD) for the verification of above residual stress results by ESPI

Oxidative Stress in Patients with Drug Resistant Partial Complex Seizure

Directory of Open Access Journals (Sweden)

Lourdes Lorigados Pedre

2018-06-01

Full Text Available Oxidative stress (OS has been implicated as a pathophysiological mechanism of drug-resistant epilepsy, but little is known about the relationship between OS markers and clinical parameters, such as the number of drugs, age onset of seizure and frequency of seizures per month. The current study’s aim was to evaluate several oxidative stress markers and antioxidants in 18 drug-resistant partial complex seizure (DRPCS patients compared to a control group (age and sex matched, and the results were related to clinical variables. We examined malondialdehyde (MDA, advanced oxidation protein products (AOPP, advanced glycation end products (AGEs, nitric oxide (NO, uric acid, superoxide dismutase (SOD, glutathione, vitamin C, 4-hydroxy-2-nonenal (4-HNE and nitrotyrosine (3-NT. All markers except 4-HNE and 3-NT were studied by spectrophotometry. The expressions of 4-HNE and 3-NT were evaluated by Western blot analysis. MDA levels in patients were significantly increased (p ≤ 0.0001 while AOPP levels were similar to the control group. AGEs, NO and uric acid concentrations were significantly decreased (p ≤ 0.004, p ≤ 0.005, p ≤ 0.0001, respectively. Expressions of 3-NT and 4-HNE were increased (p ≤ 0.005 similarly to SOD activity (p = 0.0001, whereas vitamin C was considerably diminished (p = 0.0001. Glutathione levels were similar to the control group. There was a positive correlation between NO and MDA with the number of drugs. The expression of 3-NT was positively related with the frequency of seizures per month. There was a negative relationship between MDA and age at onset of seizures, as well as vitamin C with seizure frequency/month. We detected an imbalance in the redox state in patients with DRCPS, supporting oxidative stress as a relevant mechanism in this pathology. Thus, it is apparent that some oxidant and antioxidant parameters are closely linked with clinical variables.

Does Leisure Time as a Stress Coping Resource Increase Affective Complexity? Applying the Dynamic Model of Affect (DMA)

Science.gov (United States)

Qian, Xinyi (Lisa); Yarnal, Careen M.; Almeida, David M.

2013-01-01

Affective complexity, a manifestation of psychological well-being, refers to the relative independence between positive and negative affect (PA, NA). According to the Dynamic Model of Affect (DMA), stressful situations lead to highly inverse PA-NA relationship, reducing affective complexity. Meanwhile, positive events can sustain affective complexity by restoring PA-NA independence. Leisure, a type of positive events, has been identified as a coping resource. This study used the DMA to assess whether leisure time helps restore affective complexity on stressful days. We found that on days with more leisure time than usual, an individual experienced less negative PA-NA relationship after daily stressful events. The finding demonstrates the value of leisure time as a coping resource and the DMA’s contribution to coping research. PMID:24659826

Enhanced electron-lattice coupling under uniaxial stress in layered double hydroxides intercalated with samarium complexes

International Nuclear Information System (INIS)

Park, Ta-Ryeong

2004-01-01

We have applied uniaxial stress to samarium complexes by intercalating them into the gallery of a layered material and by using a diamond-anvil cell at 28 K. Although uniaxial stress reduces symmetry and removes degeneracy, the overall number of photoluminescence (PL) peaks evidently decreased with the application of uniaxial stress. This contradictory observation is explained by an increased electron-lattice coupling strength under uniaxial stress. This behavior is also confirmed by time-resolved PL data.

Stress state evaluation in low carbon and TRIP steels by magnetic permeability

International Nuclear Information System (INIS)

Kouli, M.-E.; Giannakis, M

2016-01-01

Magnetic permeability is an indicative factor for the steel health monitoring. The measurements of magnetic permeability lead to the evaluation of the stress state of any ferromagnetic steel. The magnetic permeability measurements were conducted on low carbon and TRIP steel samples, which were subjected to both tensile and compressive stresses. The results indicated a direct correlation of the magnetic permeability with the mechanical properties, the stress state and the microstructural features of the examined samples. (paper)

Stress-induced state transitions in flexible liquid-crystal devices

International Nuclear Information System (INIS)

Ho, I-Lin; Chang, Yia-Chung

2012-01-01

This work studies the stress-strain dynamics for the transient optoelectronic characteristics of flexible liquid-crystal (LC) devices. Due to the fast response of LC directors, the configuration of the LC is assumed to be in quasi-equilibrium during the process of elastic deformations of the flexible structures. The LC medium hence can be treated effectively as a thin-film layer and can approximately follow the strain-stress mechanism in the solids. Relevant theoretical algorithms are studied in this work, and numerical results present the stress-induced state transitions in the π cell.

Posttraumatic stress disorder: a state-of-the-science review.

Science.gov (United States)

Nemeroff, Charles B; Bremner, J Douglas; Foa, Edna B; Mayberg, Helen S; North, Carol S; Stein, Murray B

2006-02-01

This article reviews the state-of-the-art research in posttraumatic stress disorder (PTSD) from several perspectives: (1) Sex differences: PTSD is more frequent among women, who tend to have different types of precipitating traumas and higher rates of comorbid panic disorder and agoraphobia than do men. (2) Risk and resilience: The presence of Group C symptoms after exposure to a disaster or act of terrorism may predict the development of PTSD as well as comorbid diagnoses. (3) Impact of trauma in early life: Persistent increases in CRF concentration are associated with early life trauma and PTSD, and may be reversed with paroxetine treatment. (4) Imaging studies: Intriguing findings in treated and untreated depressed patients may serve as a paradigm of failed brain adaptation to chronic emotional stress and anxiety disorders. (5) Neural circuits and memory: Hippocampal volume appears to be selectively decreased and hippocampal function impaired among PTSD patients. (6) Cognitive behavioral approaches: Prolonged exposure therapy, a readily disseminated treatment modality, is effective in modifying the negative cognitions that are frequent among PTSD patients. In the future, it would be useful to assess the validity of the PTSD construct, elucidate genetic and experiential contributing factors (and their complex interrelationships), clarify the mechanisms of action for different treatments used in PTSD, discover ways to predict which treatments (or treatment combinations) will be successful for a given individual, develop an operational definition of remission in PTSD, and explore ways to disseminate effective evidence-based treatments for this condition.

Simulation of Stress-Strain State of Shovel Rotary Support Kingpin

Science.gov (United States)

Khoreshok, A. A.; Buyankin, P. V.; Vorobiev, A. V.; Dronov, A. A.

2016-04-01

The article presents the sequence of computational simulation of stress-strain state of shovel’s rotary support. Computation results are analyzed, the kingpin is specified as the most loaded element, maximum stress zones are identified. Kingpin design modification such as enhancement of fillet curvature radius to 25 mm and displacement of eyebolt holes on the diameter of 165 mm are proposed, thus diminishing impact of stress concentrators and improving reliability of the rotary support.

Shallow Lunar Seismic Activity and the Current Stress State of the Moon

Science.gov (United States)

Watters, Thomas R.; Weber, Renee C.; Collins, Geoffrey C.; Johnson, Catherine L.

2017-01-01

A vast, global network of more than 3200 lobate thrust fault scarps has been revealed in high resolution Lunar Reconnaissance Orbiter Camera (LROC) images. The fault scarps are very young, less than 50 Ma, based on their small scale and crisp appearance, crosscutting relations with small-diameter impact craters, and rates of infilling of associated small, shallow graben and may be actively forming today. The population of young thrust fault scarps provides a window into the recent stress state of the Moon and offers insight into the origin of global lunar stresses. The distribution of orientations of the fault scarps is non-random, inconsistent with isotropic stresses from late-stage global contraction as the sole source of stress. Modeling shows that tidal stresses contribute significantly to the current stress state of the lunar crust. Tidal stresses (orbital recession and diurnal tides) superimposed on stresses from global contraction result in non-isotropic compressional stress and may produce thrust faults consistent with lobate scarp orientations. At any particular point on the lunar surface, peak compressive stress will be reached at a certain time in the diurnal cycle. Coseismic slip events on currently active thrust faults are expected to be triggered when peak stresses are reached. Analysis of the timing of the 28 the shallow moonquakes recorded by the Apollo seismic network shows that 19 indeed occur when the Moon is closer to apogee, while only 9 shallow events occur when the Moon is closer to perigee. Here we report efforts to refine the model for the current stress state of the Moon by investigating the contribution of polar wander. Progress on relocating the epicentral locations of the shallow moonquakes using an algorithm designed for sparse networks is also reported.

Off-state stress and pulse response investigation of InAl/Ga HFET

International Nuclear Information System (INIS)

Florovic, M.; Hronec, P.; Kovac, J.; Skriniarova, J.; Donoval, D.; Kordos, P.

2011-01-01

In this study In 0.18 Al 0.82 N/GaN HFETs were off-state tested under high drain bias, I-V characteristics were measured using standard DC voltage source (drain-source, gate-source). Subsequently drain current responses on pulse gate-source voltage for various drain-source voltages were recorded and analysed. Static performance of InAlN/GaN HFETs with AlN buffer layer prepared at different conditions were analysed before, during and after the off-state stress. The static output I-V characteristics show the maximum drain current I d ≅ 0,44 A/mm for V gs = 6 V, the device has pinch-off at V gs - 4.4 V. The drain and gate currents of the InAlN/GaN HFET were measured continuously during the off-state stress (V ds = 30 V, V gs = -4.4 V), a partial increase of the drain/gate current was observed after this interruption, which indicates on some recovery effect. The devices were characterised in details after the total stress time of 60 min., as well as after 30 min without the stress, the output I-V characteristic show permanent off-state stress degradation. This effect will be studied in details in the next. (authors)

Stress state estimation in multilayer support of vertical shafts, considering off-design cross-sectional deformation

Science.gov (United States)

Antsiferov, SV; Sammal, AS; Deev, PV

2018-03-01

To determine the stress-strain state of multilayer support of vertical shafts, including cross-sectional deformation of the tubing rings as against the design, the authors propose an analytical method based on the provision of the mechanics of underground structures and surrounding rock mass as the elements of an integrated deformable system. The method involves a rigorous solution of the corresponding problem of elasticity, obtained using the mathematical apparatus of the theory of analytic functions of a complex variable. The design method is implemented as a software program allowing multivariate applied computation. Examples of the calculation are given.

The influence of normal fault on initial state of stress in rock mass

Directory of Open Access Journals (Sweden)

Tajduś Antoni

2016-03-01

Full Text Available Determination of original state of stress in rock mass is a very difficult task for rock mechanics. Yet, original state of stress in rock mass has fundamental influence on secondary state of stress, which occurs in the vicinity of mining headings. This, in turn, is the cause of the occurrence of a number of mining hazards, i.e., seismic events, rock bursts, gas and rock outbursts, falls of roof. From experience, it is known that original state of stress depends a lot on tectonic disturbances, i.e., faults and folds. In the area of faults, a great number of seismic events occur, often of high energies. These seismic events, in many cases, are the cause of rock bursts and damage to the constructions located inside the rock mass and on the surface of the ground. To estimate the influence of fault existence on the disturbance of original state of stress in rock mass, numerical calculations were done by means of Finite Element Method. In the calculations, it was tried to determine the influence of different factors on state of stress, which occurs in the vicinity of a normal fault, i.e., the influence of normal fault inclination, deformability of rock mass, values of friction coefficient on the fault contact. Critical value of friction coefficient was also determined, when mutual dislocation of rock mass part separated by a fault is impossible. The obtained results enabled formulation of a number of conclusions, which are important in the context of seismic events and rock bursts in the area of faults.

The influence of normal fault on initial state of stress in rock mass

Science.gov (United States)

Tajduś, Antoni; Cała, Marek; Tajduś, Krzysztof

2016-03-01

Determination of original state of stress in rock mass is a very difficult task for rock mechanics. Yet, original state of stress in rock mass has fundamental influence on secondary state of stress, which occurs in the vicinity of mining headings. This, in turn, is the cause of the occurrence of a number of mining hazards, i.e., seismic events, rock bursts, gas and rock outbursts, falls of roof. From experience, it is known that original state of stress depends a lot on tectonic disturbances, i.e., faults and folds. In the area of faults, a great number of seismic events occur, often of high energies. These seismic events, in many cases, are the cause of rock bursts and damage to the constructions located inside the rock mass and on the surface of the ground. To estimate the influence of fault existence on the disturbance of original state of stress in rock mass, numerical calculations were done by means of Finite Element Method. In the calculations, it was tried to determine the influence of different factors on state of stress, which occurs in the vicinity of a normal fault, i.e., the influence of normal fault inclination, deformability of rock mass, values of friction coefficient on the fault contact. Critical value of friction coefficient was also determined, when mutual dislocation of rock mass part separated by a fault is impossible. The obtained results enabled formulation of a number of conclusions, which are important in the context of seismic events and rock bursts in the area of faults.

Finite-State Complexity and the Size of Transducers

Directory of Open Access Journals (Sweden)

Cristian Calude

2010-08-01

Full Text Available Finite-state complexity is a variant of algorithmic information theory obtained by replacing Turing machines with finite transducers. We consider the state-size of transducers needed for minimal descriptions of arbitrary strings and, as our main result, we show that the state-size hierarchy with respect to a standard encoding is infinite. We consider also hierarchies yielded by more general computable encodings.

Specific strain work as a failure criterion in plane stress state

International Nuclear Information System (INIS)

Zuchowski, R.; Zietkowski, L.

1985-01-01

An experimental verification of failure criterion based on specific strain work was performed. Thin-walled cylindrical specimens were examined by loading with constant force and constant torque moment, assuming different values for particular tests, at the same time keeping stress intensity constant, and by subjecting to thermal cycling. It was found that the critical value of failure did not depend on axial-to-shearing stresses ratio, i.e., on the type of state of stress. Thereby, the validity of the analysed failure criterion in plane stress was confirmed. Besides, a simple description of damage development in plane stress was suggested. (orig./RF)

Composition of the SAGA complex in plants and its role in controlling gene expression in response to abiotic stresses.

Directory of Open Access Journals (Sweden)

Felipe eMoraga

2015-10-01

Full Text Available Protein complexes involved in epigenetic regulation of transcription have evolved as molecular strategies to face environmental stress in plants. SAGA (Spt–Ada–Gcn5 Acetyltransferase is a transcriptional co-activator complex that regulates numerous cellular processes through the coordination of multiple post-translational histone modifications, including acetylation, deubiquitination, and chromatin recognition. The diverse functions of the SAGA complex involve distinct modules that are highly conserved between yeast, flies, and mammals. In this review, the composition of the SAGA complex in plants is described and its role in gene expression regulation under stress conditions summarized. Some of these proteins are likely involved in the regulation of the inducible expression of genes under light, cold, drought, salt, and iron stress, although the functions of several of its components remain unknown.

Ultrafast laser spectroscopy in complex solid state materials

Energy Technology Data Exchange (ETDEWEB)

Li, Tianqi [Iowa State Univ., Ames, IA (United States)

2014-12-01

This thesis summarizes my work on applying the ultrafast laser spectroscopy to the complex solid state materials. It shows that the ultrafast laser pulse can coherently control the material properties in the femtosecond time scale. And the ultrafast laser spectroscopy can be employed as a dynamical method for revealing the fundamental physical problems in the complex material systems.

Influence of chitosan and melanin-glucan complex onto gamma-exposure with low doses and acute stressful reaction

International Nuclear Information System (INIS)

Senyuk, O.F.; Tarasenko, P.D.; Pazukhin, Eh.M.; Gorovoj, L.F.; Varlamov, V.P.

2004-01-01

Possibilities of prevention and reduction of consequences of acute exposure on the background of immobilization stress with the help of chitosan preparations and of melanin - glucan complex of highest bazidiomicetes (fungi) were studied. Tested preparations were capable to protect hematological and immunological homeostasis of line BALB/c mice from stressful reaction provoked by acute exposure and two-hour immobilization. The most expressed normalizing and adapting effect had the mixture composed of chitosan and melanin-glucan complex

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

NARCIS (Netherlands)

Forkink, M.; Basit, F.; Teixeira, J.; Swarts, H.G.; Koopman, W.J.H.; Willems, P.H.G.M.

2015-01-01

Inhibitor studies with isolated mitochondria demonstrated that complex I (CI) and III (CIII) of the electron transport chain (ETC) can act as relevant sources of mitochondrial reactive oxygen species (ROS). Here we studied ROS generation and oxidative stress induction during chronic (24h) inhibition

The relation between intensity and complexity of coronary artery lesion and oxidative stress in patients with acute coronary syndrome.

Science.gov (United States)

Turan, Turhan; Menteşe, Ümit; Ağaç, Mustafa Tarık; Akyüz, Ali Rıza; Kul, Selim; Aykan, Ahmet Çağrı; Bektaş, Hüseyin; Korkmaz, Levent; Öztaş Menteşe, Seda; Dursun, İhsan; Çelik, Şükrü

2015-10-01

Oxidative stress plays a major role in the development of atherosclerosis. However, the relationship between oxidative stress and complexity and intensity of coronary artery disease is less clear. The aim of this study is to assess the relationship between oxidative stress markers and the complexity and intensity of coronary artery disease in patients with acute coronary syndrome (ACS). Sixty-seven consecutive patients with an early phase of ACS (=22). Likewise patients were divided into two CAD severity groups according to the median Gensini score of 64: less intensive CAD with Gensini score (=64. Blood samples were taken in 1 hour within administration in order to measure total oxidative status (TOS) and total antioxidant capacity (TAC) levels determined by Erel method. Oxidative stress index (OSI) was calculated by TOS /TAC. There was no significant difference between the two SYNTAX groups for oxidative stress markers. Median TOS and OSI values were significantly high in the intensive CAD group (p=0.005, p=0.04, respectively). The Gensini score was positively correlated with TOS and OSI (p=0.003, p=0.02, respectively). Oxidative stress markers may be considered supportive laboratory parameters related to CAD intensity but not complexity in ACS patients.

On the role of the residual stress state in product manufacturing

NARCIS (Netherlands)

Zijlstra, G.; Groen, M.; Post, J.; Ocelik, V.; de Hosson, J.Th.M.

2016-01-01

This paper concentrates on the effect of the residual stress state during product manufacturing of AISI 420 steel on the final shape of the product. The work includes Finite Element (FE) calculations of the distribution of the residual stresses after metal forming and a heat treatment. The evolution

Transactional stress and coping theory in accounting for psychological states measures

Directory of Open Access Journals (Sweden)

V. Buško

2007-08-01

Full Text Available The paper examines a relative predictive value of some stable individual attributes and the processes of cognitive appraisals and coping with stress in accounting for specific components of anxiety state measures. Self-report instruments for the measurement of selected psychological constructs, i.e. perceived incompetence, externality, stress intensity and duration, situation-specific coping strategies, and the two anxiety state components, were taken in a sample of 449 male military basics trainees, ranging in age from 18-27. Hierarchical multiple regression analyses showed that the set of predictors employed could account for statistically, as well as theoretically and practically a significant part of variance in cognitive anxiety component (45,5%, and in visceral-emotional component (32,2% of the anxiety state. The extent of anxiety reactions assessed by both scales could primarily be explained by general perception of personal incompetence, as a relatively stable dimension of general self-concept. Of the ways of coping examined, reinterpretation of stressful events was the only strategy contributing to low level, whereas passivization, wishful thinking, and seeking social support contributed to higher levels of anxiety measured by both scales. The results give partial support to the basic hypotheses on the mediating role of coping in the relationships among particular components of the stress and coping models.

Stress influences decisions to break a safety rule in a complex simulation task in females.

Science.gov (United States)

Starcke, Katrin; Brand, Matthias; Kluge, Annette

2016-07-01

The current study examines the effects of acutely induced laboratory stress on a complex decision-making task, the Waste Water Treatment Simulation. Participants are instructed to follow a certain decision rule according to safety guidelines. Violations of this rule are associated with potential high rewards (working faster and earning more money) but also with the risk of a catastrophe (an explosion). Stress was induced with the Trier Social Stress Test while control participants underwent a non-stress condition. In the simulation task, stressed females broke the safety rule more often than unstressed females: χ(2) (1, N=24)=10.36, pbreak the safety rule because stressed female participants focused on the potential high gains while they neglected the risk of potential negative consequences. Copyright © 2016 Elsevier B.V. All rights reserved.

Complexity Leadership Theory: A United States Marine Corps Historical Overlay

Science.gov (United States)

2017-05-25

DD-MM-YYYY) 23-04-2017 2. REPORT TYPE Master’s Thesis 3. DATES COVERED (From - To) JUN 2016 – MAY 2017 4. TITLE AND SUBTITLE Complexity...Monograph Title : Complexity Leadership Theory : A United States Marine Corps Historical Overlay Approved by...General Ridgway’s Success in Korea.” Master’s thesis , United States Army Command and General Staff College, 2010. Diana, Gabriel. “Vision, Education

Complexity and time asymmetry of heart rate variability are altered in acute mental stress.

Science.gov (United States)

Visnovcova, Z; Mestanik, M; Javorka, M; Mokra, D; Gala, M; Jurko, A; Calkovska, A; Tonhajzerova, I

2014-07-01

We aimed to study the complexity and time asymmetry of short-term heart rate variability (HRV) as an index of complex neurocardiac control in response to stress using symbolic dynamics and time irreversibility methods. ECG was recorded at rest and during and after two stressors (Stroop, arithmetic test) in 70 healthy students. Symbolic dynamics parameters (NUPI, NCI, 0V%, 1V%, 2LV%, 2UV%), and time irreversibility indices (P%, G%, E) were evaluated. Additionally, HRV magnitude was quantified by linear parameters: spectral powers in low (LF) and high frequency (HF) bands. Our results showed a reduction of HRV complexity in stress (lower NUPI with both stressors, lower NCI with Stroop). Pattern classification analysis revealed significantly higher 0V% and lower 2LV% with both stressors, indicating a shift in sympathovagal balance, and significantly higher 1V% and lower 2UV% with Stroop. An unexpected result was found in time irreversibility: significantly lower G% and E with both stressors, P% index significantly declined only with arithmetic test. Linear HRV analysis confirmed vagal withdrawal (lower HF) with both stressors; LF significantly increased with Stroop and decreased with arithmetic test. Correlation analysis revealed no significant associations between symbolic dynamics and time irreversibility. Concluding, symbolic dynamics and time irreversibility could provide independent information related to alterations of neurocardiac control integrity in stress-related disease.

Complexity and time asymmetry of heart rate variability are altered in acute mental stress

International Nuclear Information System (INIS)

Visnovcova, Z; Mestanik, M; Javorka, M; Mokra, D; Calkovska, A; Tonhajzerova, I; Gala, M; Jurko, A

2014-01-01

We aimed to study the complexity and time asymmetry of short-term heart rate variability (HRV) as an index of complex neurocardiac control in response to stress using symbolic dynamics and time irreversibility methods. ECG was recorded at rest and during and after two stressors (Stroop, arithmetic test) in 70 healthy students. Symbolic dynamics parameters (NUPI, NCI, 0V%, 1V%, 2LV%, 2UV%), and time irreversibility indices (P%, G%, E) were evaluated. Additionally, HRV magnitude was quantified by linear parameters: spectral powers in low (LF) and high frequency (HF) bands. Our results showed a reduction of HRV complexity in stress (lower NUPI with both stressors, lower NCI with Stroop). Pattern classification analysis revealed significantly higher 0V% and lower 2LV% with both stressors, indicating a shift in sympathovagal balance, and significantly higher 1V% and lower 2UV% with Stroop. An unexpected result was found in time irreversibility: significantly lower G% and E with both stressors, P% index significantly declined only with arithmetic test. Linear HRV analysis confirmed vagal withdrawal (lower HF) with both stressors; LF significantly increased with Stroop and decreased with arithmetic test. Correlation analysis revealed no significant associations between symbolic dynamics and time irreversibility. Concluding, symbolic dynamics and time irreversibility could provide independent information related to alterations of neurocardiac control integrity in stress-related disease. (paper)

Experimental research data on stress state of salt rock mass around an underground excavation

Science.gov (United States)

Baryshnikov, VD; Baryshnikov, DV

2018-03-01

The paper presents the experimental stress state data obtained in surrounding salt rock mass around an excavation in Mir Mine, ALROSA. The deformation characteristics and the values of stresses in the adjacent rock mass are determined. Using the method of drilling a pair of parallel holes in a stressed area, the authors construct linear relationship for the radial displacements of the stress measurement hole boundaries under the short-term loading of the perturbing hole. The resultant elasticity moduli of rocks are comparable with the laboratory core test data. Pre-estimates of actual stresses point at the presence of a plasticity zone in the vicinity of the underground excavation. The stress state behavior at a distance from the excavation boundary disagrees with the Dinnik–Geim hypothesis.

Influence of Health Behaviors and Occupational Stress on Prediabetic State among Male Office Workers.

Science.gov (United States)

Ryu, Hosihn; Moon, Jihyeon; Jung, Jiyeon

2018-06-14

This study examined the influence of health behaviors and occupational stress on the prediabetic state of male office workers, and identified related risks and influencing factors. The study used a cross-sectional design and performed an integrative analysis on data from regular health checkups, health questionnaires, and a health behavior-related survey of employees of a company, using Spearman’s correlation coefficients and multiple logistic regression analysis. The results showed significant relationships of prediabetic state with health behaviors and occupational stress. Among health behaviors, a diet without vegetables and fruits (Odds Ratio (OR) = 3.74, 95% Confidence Interval (CI) = 1.93⁻7.66) was associated with a high risk of prediabetic state. In the subscales on occupational stress, organizational system in the 4th quartile (OR = 4.83, 95% CI = 2.40⁻9.70) was significantly associated with an increased likelihood of prediabetic state. To identify influencing factors of prediabetic state, the multiple logistic regression was performed using regression models. The results showed that dietary habits (β = 1.20, p = 0.002), total occupational stress score (β = 1.33, p = 0.024), and organizational system (β = 1.13, p = 0.009) were significant influencing factors. The present findings indicate that active interventions are needed at workplace for the systematic and comprehensive management of health behaviors and occupational stress that influence prediabetic state of office workers.

EVALUATION OF STRAIN-STRESS STATE OF THE RAILS IN THE PRODUCTION

Directory of Open Access Journals (Sweden)

V. V. Muravev

2017-01-01

Full Text Available High values of residual stresses is one of the most common reason of breaking lots of metal constructions, including rails. These stresses can reach values of flow limit, especially in the area of faults. Estimation of residual stresses values allows to get information about technical condition of the rail and also allow to avoid abnormal situations So, the aim of the research is creating the model of stress-strain state of the rail, which was hardened in its top and bottom, and to compare modeling results with experimental measurements of stresses and discrepancy of the housing.For creating the model and making evaluations by finite element method we used a program COMSOL. Forces on the top and bottom of the rail cause tension stresses, forces on the web of the rail cause tensile stresses. We compared calculated values of stresses with discrepancy of the housing. The discrepancy of the housing is informative characteristic for estimating the residual stresses according to standards. For experimental measurements we used an acoustic structuroscope SEMA. This structuroscope uses the acoustoelastic phenomenon for measurements. We made measurements of the five rails.According to the calculation results of the model, critical discrepancy of the housing in 2 mm corresponded to the following values of maximum stresses: –54 MPa in the top of the rail, 86 MPa in the web and –62 MPa in the bottom of the rail. Experimental measurements are the following: from –48 MPa to – 64 MPa in the top of the rail, 54 MPa to 93 MPa in the web of the rail, and –59 MPA to –74 MPa in the bottom of the rail. Absolute error was ±5 MPa.Thus we created the model, which allowed to analyze strain-stress state and compare real values of stresses with discrepancy of the housing. Results of the modeling showed coincidence with structure of distribution of residual stresses in five probes of rails. 

Solid-state NMR spectroscopy on complex biomolecules

NARCIS (Netherlands)

Renault, M.A.M.; Cukkemane, A.A.; Baldus, M.

2010-01-01

Biomolecular applications of NMR spectroscopy are often merely associated with soluble molecules or magnetic resonance imaging. However, since the late 1970s, solid-state NMR (ssNMR) spectroscopy has demonstrated its ability to provide atomic-level insight into complex biomolecular systems ranging

Solid State Pathways towards Molecular Complexity in Space

Science.gov (United States)

Linnartz, Harold; Bossa, Jean-Baptiste; Bouwman, Jordy; Cuppen, Herma M.; Cuylle, Steven H.; van Dishoeck, Ewine F.; Fayolle, Edith C.; Fedoseev, Gleb; Fuchs, Guido W.; Ioppolo, Sergio; Isokoski, Karoliina; Lamberts, Thanja; Öberg, Karin I.; Romanzin, Claire; Tenenbaum, Emily; Zhen, Junfeng

2011-12-01

It has been a long standing problem in astrochemistry to explain how molecules can form in a highly dilute environment such as the interstellar medium. In the last decennium more and more evidence has been found that the observed mix of small and complex, stable and highly transient species in space is the cumulative result of gas phase and solid state reactions as well as gas-grain interactions. Solid state reactions on icy dust grains are specifically found to play an important role in the formation of the more complex ``organic'' compounds. In order to investigate the underlying physical and chemical processes detailed laboratory based experiments are needed that simulate surface reactions triggered by processes as different as thermal heating, photon (UV) irradiation and particle (atom, cosmic ray, electron) bombardment of interstellar ice analogues. Here, some of the latest research performed in the Sackler Laboratory for Astrophysics in Leiden, the Netherlands is reviewed. The focus is on hydrogenation, i.e., H-atom addition reactions and vacuum ultraviolet irradiation of interstellar ice analogues at astronomically relevant temperatures. It is shown that solid state processes are crucial in the chemical evolution of the interstellar medium, providing pathways towards molecular complexity in space.

Analysis of residual stress state in sheet metal parts processed by single point incremental forming

Science.gov (United States)

Maaß, F.; Gies, S.; Dobecki, M.; Brömmelhoff, K.; Tekkaya, A. E.; Reimers, W.

2018-05-01

The mechanical properties of formed metal components are highly affected by the prevailing residual stress state. A selective induction of residual compressive stresses in the component, can improve the product properties such as the fatigue strength. By means of single point incremental forming (SPIF), the residual stress state can be influenced by adjusting the process parameters during the manufacturing process. To achieve a fundamental understanding of the residual stress formation caused by the SPIF process, a valid numerical process model is essential. Within the scope of this paper the significance of kinematic hardening effects on the determined residual stress state is presented based on numerical simulations. The effect of the unclamping step after the manufacturing process is also analyzed. An average deviation of the residual stress amplitudes in the clamped and unclamped condition of 18 % reveals, that the unclamping step needs to be considered to reach a high numerical prediction quality.

Modeling of the stress-strain state of the ground mass contaminated with peracetic acid

Directory of Open Access Journals (Sweden)

Levenko Anna

2017-01-01

Full Text Available None of the methods described previously provides a solution to the problem that deals with the SSS evaluation of the ground mass which is under the influence of chemically active substances and, in particular, under the influence of peracetic acid. The stress-strain state of the ground mass contaminated with peracetic acid was estimated. Stresses occurring in the ground mass in the natural state were determined after the entry of acid into it and after the chemical fixation of it with sodium silicate. All the parameters of the stress-strain state of the ground mass were obtained under a number of physical and mechanical conditions. It was determined that following the work on the silicatization of the ground mass contaminated with peracetic acid the quantity of strain decreased by 26.11 to 48.9%. The comparison of the results of stress calculations indicates the stress reduction in the ground mass in 1.8 – 2.6 times after its fixing.

Steady-State Creep of Asphalt Concrete

Directory of Open Access Journals (Sweden)

Alibai Iskakbayev

2017-02-01

Full Text Available This paper reports the experimental investigation of the steady-state creep process for fine-grained asphalt concrete at a temperature of 20 ± 2 °С and under stress from 0.055 to 0.311 MPa under direct tension and was found to occur at a constant rate. The experimental results also determined the start, the end point, and the duration of the steady-state creep process. The dependence of these factors, in addition to the steady-state creep rate and viscosity of the asphalt concrete on stress is satisfactorily described by a power function. Furthermore, it showed that stress has a great impact on the specific characteristics of asphalt concrete: stress variation by one order causes their variation by 3–4.5 orders. The described relations are formulated for the steady-state of asphalt concrete in a complex stressed condition. The dependence is determined between stress intensity and strain rate intensity.

Cellular stress induces a protective sleep-like state in C. elegans.

Science.gov (United States)

Hill, Andrew J; Mansfield, Richard; Lopez, Jessie M N G; Raizen, David M; Van Buskirk, Cheryl

2014-10-20

Sleep is recognized to be ancient in origin, with vertebrates and invertebrates experiencing behaviorally quiescent states that are regulated by conserved genetic mechanisms. Despite its conservation throughout phylogeny, the function of sleep remains debated. Hypotheses for the purpose of sleep include nervous-system-specific functions such as modulation of synaptic strength and clearance of metabolites from the brain, as well as more generalized cellular functions such as energy conservation and macromolecule biosynthesis. These models are supported by the identification of synaptic and metabolic processes that are perturbed during prolonged wakefulness. It remains to be seen whether perturbations of cellular homeostasis in turn drive sleep. Here we show that under conditions of cellular stress, including noxious heat, cold, hypertonicity, and tissue damage, the nematode Caenorhabditis elegans engages a behavioral quiescence program. The stress-induced quiescent state displays properties of sleep and is dependent on the ALA neuron, which mediates the conserved soporific effect of epidermal growth factor (EGF) ligand overexpression. We characterize heat-induced quiescence in detail and show that it is indeed dependent on components of EGF signaling, providing physiological relevance to the behavioral effects of EGF family ligands. We find that after noxious heat exposure, quiescence-defective animals show elevated expression of cellular stress reporter genes and are impaired for survival, demonstrating the benefit of stress-induced behavioral quiescence. These data provide evidence that cellular stress can induce a protective sleep-like state in C. elegans and suggest that a deeply conserved function of sleep is to mitigate disruptions of cellular homeostasis. Copyright © 2014 Elsevier Ltd. All rights reserved.

Deciphering Stress State of Seismogenic Faults in Oklahoma and Kansas Based on High-resolution Stress Maps

Science.gov (United States)

Qin, Y.; Chen, X.; Haffener, J.; Trugman, D. T.; Carpenter, B.; Reches, Z.

2017-12-01

Induced seismicity in Oklahoma and Kansas delineates clear fault trends. It is assumed that fluid injection reactivates faults which are optimally oriented relative to the regional tectonic stress field. We utilized recently improved earthquake locations and more complete focal mechanism catalogs to quantitatively analyze the stress state of seismogenic faults with high-resolution stress maps. The steps of analysis are: (1) Mapping the faults by clustering seismicity using a nearest-neighbor approach, manually picking the fault in each cluster and calculating the fault geometry using principal component analysis. (2) Running a stress inversion with 0.2° grid spacing to produce an in-situ stress map. (3) The fault stress state is determined from fault geometry and a 3D Mohr circle. The parameter `understress' is calculated to quantify the criticalness of these faults. If it approaches 0, the fault is critically stressed; while understress=1 means there is no shear stress on the fault. Our results indicate that most of the active faults have a planar shape (planarity>0.8), and dip steeply (dip>70°). The fault trends are distributed mainly in conjugate set ranges of [50°,70°] and [100°,120°]. More importantly, these conjugate trends are consistent with mapped basement fractures in southern Oklahoma, suggesting similar basement features from regional tectonics. The fault length data shows a loglinear relationship with the maximum earthquake magnitude with an expected maximum magnitude range from 3.2 to 4.4 for most seismogenic faults. Based on 3D local Mohr circle, we find that 61% of the faults have low understress (0.5) are located within highest-rate injection zones and therefore are likely to be influenced by high pore pressure. The faults that hosted the largest earthquakes, M5.7 Prague and M5.8 Pawnee are critically stressed (understress 0.2). These differences may help in understanding earthquake sequences, for example, the predominantly aftershock

Calorimetric features of release of plastic deformation induced internal stresses, and approach to equilibrium state on annealing of crystals and glasses

Energy Technology Data Exchange (ETDEWEB)

Johari, G.P., E-mail: joharig@mcmaster.ca

2014-04-01

Highlights: • Stress release in a glass occurs at a faster rate than structural relaxation. • Plastically-deformed glass would show two exothermic minima, and no glass transition. • Enthalpy matching procedure would yield an inaccurate fictive temperature. • Complex heat capacity may distinguish plastically-deformed from quench-formed glass. - Abstract: Plastic deformation of crystals and glasses produces internal strains (stresses), which change their energy and other thermodynamic properties. On annealing, these stresses decrease at a rate faster than the structure relaxes toward the equilibrium state. Mechanism of such relaxations in crystals differs from that in glasses and it also differs for glasses of different types. In all cases, the energy related properties decrease with time isothermally and on heating, resembling the structure relaxation of a stress-free glass. We consider these features and argue that kinetics of enthalpy loss with time yields the rate constants of the stress release and of the structure change, and not the viscosity determining α-relaxation time. Since thermal cycling does not recover the enthalpy from internal stresses, a glass with stresses has neither a glass-softening temperature, T{sub g}, nor a fictive temperature, T{sub f}. Plastic deformation would not rejuvenate a physically aged glass to the properties of its un-aged state. The Prigogine–Defay ratio can be extended to all T{sub f}s, and used to investigate the effect of distribution of relaxation times on its value, but it can not be defined for an internally stressed glass. After discussing the effects of annealing on the heat capacity and DSC scans, we conclude that on slow heating, glass with deformation-induced stresses would show two exothermic minima, and normal glass would show only one such minimum. Temperature-modulated scanning calorimetry would also distinguish an internally stressed glass from an equally high-enthalpy, stress-free glass. Enthalpy

Structure/property relations of aluminum under varying rates and stress states

Energy Technology Data Exchange (ETDEWEB)

Tucker, Matthew T [Los Alamos National Laboratory; Horstemeyer, Mark F [MISSISSIPPI STATE UNIV; Whittington, Wilburn R [MISSISSIPPI STATE UNIV; Solanki, Kiran N [MISSISSIPPI STATE UNIV.

2010-11-19

In this work we analyze the plasticity, damage, and fracture characteristics of three different processed aluminum alloys (rolled 5083-H13, cast A356-T6, and extruded 6061-T6) under varying stress states (tension, compression, and torsion) and strain rates (0.001/, 1/s., and 1000/s). The stress state difference had more of a flow stress effect than the applied strain rates for those given in this study (0.001/sec up to 1000/sec). The stress state and strain rate also had a profound effect on the damage evolution of each aluminum alloy. Tension and torsional straining gave much greater damage nucleation rates than compression. Although the damage of all three alloys was found to be void nucleation dominated, the A356-T6 and 5083-H131 aluminum alloys incurred void damage via micron scale particles where the 6061-T6 aluminum alloy incurred void damage from two scales, micron-scale particles and nanoscale precipitates. Having two length scales of particles that participated in the damage evolution made the 6061-T6 incur a strain rate sensitive damage rate that was different than the other two aluminum alloys. Under tension, as the strain rate increased, the 6061-T6 aluminum alloy's void nucleation rate decreased, but the A356-T6 and 5083-H131 aluminum alloys void nucleation rate increased.

Relationship between Organizational Climate, Job Stress and Job Performance Officer at State Education Department

Science.gov (United States)

Suandi, Turiman; Ismail, Ismi Arif; Othman, Zulfadli

2014-01-01

This research aims at finding out the relationship between Organizational Climate, job stress and job performance among State Education Department (JPN) officers . The focus of the research is to determine the job performance of state education department officers, level of job stress among the officers, level of connection between organizational…

Accumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex

KAUST Repository

Döll, Stefanie

2017-12-09

Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that scopolin accumulation can be induced in the root by osmotic stress and in the leaf by low-temperature stress in Arabidopsis thaliana. A genetic screen for altered scopolin levels in A. thaliana revealed a mutant compromised in scopolin accumulation in response to stress; the lesion was present in a homologue of THO1 coding for a subunit of the THO/TREX complex. The THO/TREX complex contributes to RNA silencing, supposedly by trafficking precursors of small RNAs. Mutants defective in THO, AGO1, SDS3 and RDR6 were impaired with respect to scopolin accumulation in response to stress, suggesting a mechanism based on RNA silencing such as the trans-acting small interfering RNA pathway, which requires THO/TREX function.

Inflammasomes: sensors of metabolic stresses for vascular inflammation

OpenAIRE

Yin, Ying; Pastrana, Jahaira Lopez; Li, Xinyuan; Huang, Xiao; Mallilankaraman, karthik; Choi, Eric T.; Madesh, Muniswamy; Wang, Hong; Yang, Xiao-Feng

2013-01-01

Metabolic syndrome is a major health issue in the western world. An elevated pro-inflammatory state is often found in patients with metabolic diseases such as type 2 diabetes and obesity. Atherosclerosis is one such clinical manifestation of pro-inflammatory state associated with the vasculature. The exact mechanism by which metabolic stress induces this pro-inflammatory status and promotes atherogenesis remained elusive until the discovery of the inflammasome protein complex. This complex is...

Residual stress state in pipe cut ring specimens for fracture toughness testing

Energy Technology Data Exchange (ETDEWEB)

Damjanovic, Darko [J.J. Strossmayer Univ. of Osijek, Slavonski Brod (Croatia). Mechanical Engineering Faculty; Kozak, Drazan [Zagreb Univ. (Croatia). Dept. for Mechanical Design; Marsoner, Stefan [Materials Center, Leoben (Austria).; Gubeljak, Nenad [Maribor Univ. (Slovenia). Chair of Mechanics

2017-07-01

Thin-walled pipes are not suitable for measuring fracture toughness parameters of vital importance because longitudinal crack failure is the most common failure mode in pipes. This is due to the impossibility to manufacture standard specimens for measuring fracture toughness, such as SENB or CT specimens, from the thin wall of the pipe. Previous works noticed this problem, but until now, a good and convenient solution has not been found or developed. To overcome this problem, very good alternative solution was proposed, the so-called pipe ring notched bend specimen (PRNB) [1-5]. Until now, only the idealized geometry PRNB specimen is analyzed, i. e., a specimen which is not cut out from an actual pipe but produced from steel plate. Based on that, residual stresses are neglected along with the imperfections in geometry (elliptical and eccentricity). The aim of this research is to estimate the residual stress state(s) in real pipes used in the boiler industry produced by hot rolling technique. These types of pipes are delivered only in normalized condition, but not stress relieved. Therefore, there are residual stresses present due to the manufacturing technique, but also due to uneven cooling after the production process. Within this paper, residual stresses are estimated by three methods: the incremental hole drilling method (IHMD), X-ray diffraction (XRD) and the splitting method (SM). Knowing the residual stress state in the ring specimen, it is possible to assess their impact on fracture toughness measured on the corresponding PRNB specimen(s).

Residual stress state in pipe cut ring specimens for fracture toughness testing

International Nuclear Information System (INIS)

Damjanovic, Darko; Kozak, Drazan; Marsoner, Stefan; Gubeljak, Nenad

2017-01-01

Thin-walled pipes are not suitable for measuring fracture toughness parameters of vital importance because longitudinal crack failure is the most common failure mode in pipes. This is due to the impossibility to manufacture standard specimens for measuring fracture toughness, such as SENB or CT specimens, from the thin wall of the pipe. Previous works noticed this problem, but until now, a good and convenient solution has not been found or developed. To overcome this problem, very good alternative solution was proposed, the so-called pipe ring notched bend specimen (PRNB) [1-5]. Until now, only the idealized geometry PRNB specimen is analyzed, i. e., a specimen which is not cut out from an actual pipe but produced from steel plate. Based on that, residual stresses are neglected along with the imperfections in geometry (elliptical and eccentricity). The aim of this research is to estimate the residual stress state(s) in real pipes used in the boiler industry produced by hot rolling technique. These types of pipes are delivered only in normalized condition, but not stress relieved. Therefore, there are residual stresses present due to the manufacturing technique, but also due to uneven cooling after the production process. Within this paper, residual stresses are estimated by three methods: the incremental hole drilling method (IHMD), X-ray diffraction (XRD) and the splitting method (SM). Knowing the residual stress state in the ring specimen, it is possible to assess their impact on fracture toughness measured on the corresponding PRNB specimen(s).

Bipartite quantum states and random complex networks

International Nuclear Information System (INIS)

Garnerone, Silvano; Zanardi, Paolo; Giorda, Paolo

2012-01-01

We introduce a mapping between graphs and pure quantum bipartite states and show that the associated entanglement entropy conveys non-trivial information about the structure of the graph. Our primary goal is to investigate the family of random graphs known as complex networks. In the case of classical random graphs, we derive an analytic expression for the averaged entanglement entropy S-bar while for general complex networks we rely on numerics. For a large number of nodes n we find a scaling S-bar ∼c log n +g e where both the prefactor c and the sub-leading O(1) term g e are characteristic of the different classes of complex networks. In particular, g e encodes topological features of the graphs and is named network topological entropy. Our results suggest that quantum entanglement may provide a powerful tool for the analysis of large complex networks with non-trivial topological properties. (paper)

Stress drops of induced and tectonic earthquakes in the central United States are indistinguishable.

Science.gov (United States)

Huang, Yihe; Ellsworth, William L; Beroza, Gregory C

2017-08-01

Induced earthquakes currently pose a significant hazard in the central United States, but there is considerable uncertainty about the severity of their ground motions. We measure stress drops of 39 moderate-magnitude induced and tectonic earthquakes in the central United States and eastern North America. Induced earthquakes, more than half of which are shallower than 5 km, show a comparable median stress drop to tectonic earthquakes in the central United States that are dominantly strike-slip but a lower median stress drop than that of tectonic earthquakes in the eastern North America that are dominantly reverse-faulting. This suggests that ground motion prediction equations developed for tectonic earthquakes can be applied to induced earthquakes if the effects of depth and faulting style are properly considered. Our observation leads to the notion that, similar to tectonic earthquakes, induced earthquakes are driven by tectonic stresses.

Structure of the Deactive State of Mammalian Respiratory Complex I.

Science.gov (United States)

Blaza, James N; Vinothkumar, Kutti R; Hirst, Judy

2018-02-06

Complex I (NADH:ubiquinone oxidoreductase) is central to energy metabolism in mammalian mitochondria. It couples NADH oxidation by ubiquinone to proton transport across the energy-conserving inner membrane, catalyzing respiration and driving ATP synthesis. In the absence of substrates, active complex I gradually enters a pronounced resting or deactive state. The active-deactive transition occurs during ischemia and is crucial for controlling how respiration recovers upon reperfusion. Here, we set a highly active preparation of Bos taurus complex I into the biochemically defined deactive state, and used single-particle electron cryomicroscopy to determine its structure to 4.1 Å resolution. We show that the deactive state arises when critical structural elements that form the ubiquinone-binding site become disordered, and we propose reactivation is induced when substrate binding to the NADH-reduced enzyme templates their reordering. Our structure both rationalizes biochemical data on the deactive state and offers new insights into its physiological and cellular roles. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Stress evaluation of metallic material under steady state based on nonlinear critically refracted longitudinal wave

Science.gov (United States)

Mao, Hanling; Zhang, Yuhua; Mao, Hanying; Li, Xinxin; Huang, Zhenfeng

2018-06-01

This paper presents the study of applying the nonlinear ultrasonic wave to evaluate the stress state of metallic materials under steady state. The pre-stress loading method is applied to guarantee components with steady stress. Three kinds of nonlinear ultrasonic experiments based on critically refracted longitudinal wave are conducted on components which the critically refracted longitudinal wave propagates along x, x1 and x2 direction. Experimental results indicate the second and third order relative nonlinear coefficients monotonically increase with stress, and the normalized relationship is consistent with simplified dislocation models, which indicates the experimental result is logical. The combined ultrasonic nonlinear parameter is proposed, and three stress evaluation models at x direction are established based on three ultrasonic nonlinear parameters, which the estimation error is below 5%. Then two stress detection models at x1 and x2 direction are built based on combined ultrasonic nonlinear parameter, the stress synthesis method is applied to calculate the magnitude and direction of principal stress. The results show the prediction error is within 5% and the angle deviation is within 1.5°. Therefore the nonlinear ultrasonic technique based on LCR wave could be applied to nondestructively evaluate the stress of metallic materials under steady state which the magnitude and direction are included.

Application of the Raman technique to measure stress states in individual Si particles in a cast Al-Si alloy

International Nuclear Information System (INIS)

Harris, Stephen J.; O'Neill, Ann; Boileau, James; Donlon, William; Su, Xuming; Majumdar, B.S.

2007-01-01

While Raman spectroscopy is often used to measure stresses, the analyses are almost always limited to cases with simple stress states (uniaxial, equibiaxial). Recently we provided an experimental methodology to determine the full state of stress in Si wafers. Here we extend that methodology to interrogate stress states in Si particles embedded in an Al-Si alloy. Such determinations will ultimately be valuable for predicting ductility of cast Al, since a primary source of damage is cracking of eutectic Si particles. We combine electron back-scattered diffraction with the frequency shift, polarization and intensity of the Raman light to determine stress states. Stress states are measured both in the as-received residually stressed state and under in situ uniaxial loading. Comparison with finite element calculations shows good agreement. As an application of the technique, we show the determination of strength of an individual Si particle and compare the stress evolution with various models

Stress among Secondary School Teachers in Ebonyi State, Nigeria: Suggested Interventions in the Worksite Milieu

Science.gov (United States)

Nwimo, Ignatius O.; Onwunaka, Chinagorom

2015-01-01

The aim of the study was to determine the level of stress experienced by secondary school teachers in Ebonyi State. The dimensions of stress studied included physical stress, mental stress, emotional stress and social stress. The study adopted the cross-sectional survey design using a sample of 660 (male 259, female 401) teachers randomly drawn…

Fault-patch stress-transfer efficiency in presence of sub-patch geometric complexity

KAUST Repository

Zielke, Olaf

2015-04-01

It is well known that faults are not planar surfaces. Instead they exhibit self-similar or self-affine properties that span a wide range of spatial (sub-micrometer to tens-of-kilometer). This geometric fault roughness has a distinct impact on amount and distribution of stresses/strains induced in the medium and on other portions of the fault. However, when numerically simulated (for example in multi-cycle EQ rupture simulations or Coulomb failure stress calculations) this roughness is largely ignored: individual fault patches --the incremental elements that build the fault surface in the respective computer models-- are planar and fault roughness at this and lower spatial scales is not considered. As a result, the fault-patch stress-transfer efficiency may be systematically too large in those numerical simulations with respect to the "actual" efficiency level. Here, we investigate the effect of sub-patch geometric complexity on fault-patch stress-transfer efficiency. For that, we sub-divide a fault patch (e.g., 1x1km) into a large number of sub-patches (e.g., 20x20m) and determine amount of induced stresses at selected positions around that patch for different levels and realizations of fault roughness. For each fault roughness level, we compute mean and standard deviation of the induced stresses, enabling us to compute the coefficient of variation. We normalize those values with stresses from the corresponding single (planar) fault patch, providing scaling factors and their variability for stress transfer efficiency. Given a certain fault roughness that is assumed for a fault, this work provides the means to implement the sub-patch fault roughness into investigations based on fault-patch interaction schemes.

From point-wise stress data to a continuous description of the 3D crustal in situ stress state

Science.gov (United States)

Heidbach, O.; Ziegler, M.; Reiter, K.; Hergert, T.

2017-12-01

The in situ stress is a key parameter for the safe and sustainable management of geo-reservoirs or storage of waste and energy in deep geological repositories. It is also an essential initial condition for thermo-hydro-mechanical (THM) models that investigate man-made induced processes e.g. seismicity due to fluid injection/extraction, reservoir depletion or storage of heat producing high-level radioactive waste. Without a reasonable assumption on the initial stress condition it is not possible to assess if a man-made process is pushing the system into a critical state or not. However, modelling the initial 3D stress state on reservoir scale is challenging since data are hardly available before drilling in the area of interest. This is in particular the case for the stress magnitude data which are a prerequisite for a reliable model calibration. Here, we present a multi-stage 3D geomechani­cal-numerical model approach to estimate for a reservoir-scale volume the 3D in situ stress state. First, we set up a large-scale model which is calibrated by stress data and use the modelled stress field subsequently to calibrate a small-scale model located within the large-scale model. The local model contains a significantly higher resolution representation of the subsurface geometry around boreholes of a projected geothermal power plant. This approach incorporates two models and is an alternative to the required trade-off between resolution, computational cost and calibration data which is inevitable for a single model; an extension to a three-stage approach would be straight forward. We exemplify the two-stage approach for the area around Munich in the German Molasse Basin. The results of the reservoir-scale model are presented in terms of values for slip tendency as a measure for the criticality of fault reactivation. The model results show that variations due to uncertainties in the input data are mainly introduced by the uncertain material properties and missing

Phase-based treatment of a complex severely mentally ill case involving complex posttraumatic stress disorder and psychosis related to Dandy Walker syndrome

NARCIS (Netherlands)

Mauritz, M.W.; van de Sande, R.; Goossens, P.J.J.; van Achterberg, T.; Draijer, N.

2014-01-01

For patients with comorbid complex posttraumatic stress disorder (PTSD) and psychotic disorder, trauma-focused therapy may be difficult to endure. Phase-based treatment including (a) stabilization, (b) trauma-focused therapy, and (c) integration of personality with recovery of connection appears to

Optimized Binomial Quantum States of Complex Oscillators with Real Spectrum

International Nuclear Information System (INIS)

Zelaya, K D; Rosas-Ortiz, O

2016-01-01

Classical and nonclassical states of quantum complex oscillators with real spectrum are presented. Such states are bi-orthonormal superpositions of n +1 energy eigenvectors of the system with binomial-like coefficients. For large values of n these optimized binomial states behave as photon added coherent states when the imaginary part of the potential is cancelled. (paper)

Space-time complexity in solid state models

International Nuclear Information System (INIS)

Bishop, A.R.

1985-01-01

In this Workshop on symmetry-breaking it is appropriate to include the evolving fields of nonlinear-nonequilibrium systems in which transitions to and between various degrees of ''complexity'' (including ''chaos'') occur in time or space or both. These notions naturally bring together phenomena of pattern formation and chaos and therefore have ramifications for a huge array of natural sciences - astrophysics, plasmas and lasers, hydrodynamics, field theory, materials and solid state theory, optics and electronics, biology, pattern recognition and evolution, etc. Our particular concerns here are with examples from solid state and condensed matter

Tracking excited-state charge and spin dynamics in iron coordination complexes

DEFF Research Database (Denmark)

Zhang, Wenkai; Alonso-Mori, Roberto; Bergmann, Uwe

2014-01-01

to spin state, can elucidate the spin crossover dynamics of [Fe(2,2'-bipyridine)(3)](2+) on photoinduced metal-to-ligand charge transfer excitation. We are able to track the charge and spin dynamics, and establish the critical role of intermediate spin states in the crossover mechanism. We anticipate......Crucial to many light-driven processes in transition metal complexes is the absorption and dissipation of energy by 3d electrons(1-4). But a detailed understanding of such non-equilibrium excited-state dynamics and their interplay with structural changes is challenging: a multitude of excited...... states and possible transitions result in phenomena too complex to unravel when faced with the indirect sensitivity of optical spectroscopy to spin dynamics(5) and the flux limitations of ultrafast X-ray sources(6,7). Such a situation exists for archetypal poly-pyridyl iron complexes, such as [Fe(2...

Effect of Stress State on Fracture Features

Science.gov (United States)

Das, Arpan

2018-02-01

Present article comprehensively explores the influence of specimen thickness on the quantitative estimates of different ductile fractographic features in two dimensions, correlating tensile properties of a reactor pressure vessel steel tested under ambient temperature where the initial crystallographic texture, inclusion content, and their distribution are kept unaltered. It has been investigated that the changes in tensile fracture morphology of these steels are directly attributable to the resulting stress-state history under tension for given specimen dimensions.

The State – Nation Imbalance. Peace and Complex Circumstances

Directory of Open Access Journals (Sweden)

Cristian - Sorin Prună

2008-06-01

Full Text Available The defining reference points of this paper take into consideration the creation of severalscientific premises which would structure the approached issue - constitutional state (nationcorrelated with the term security – by reference to the current international context coordinates. Thegoal of the proposed approach is organising the elements which define the security of theconstitutional state from the perspective of the coexistence between peace and complex situations(crisis and war. In the effort of organising such a scientific matter, we attempted to realise clear,concise boundaries by means of research – the study and analysis of conflicting phenomena(conclusive factors / consequences. Thus, we pointed out the role of the modern constitutional statein the current context, the inference between the state – nation balance, through its components, topreserve peace and nation security through efficient management of complex situations.

Relationship of Challenge and Hindrance Stress with Coping Style and Job Satisfaction in Chinese State-Owned Enterprises

OpenAIRE

Yamaguchi, Hiroyuki; Zhao, Dong Mei

2008-01-01

This study aimed to categorize stresses prevalent in Chinese state-owned enterprises and to investigate the relationships among stresses, coping styles and job satisfaction. Data ( n = 549) were collected from three state-owned enterprises in Cang Zhou, He Bei Province, Mainland China. The result of a factor analysis yielded the following three factors: enterprise stress, interpersonal stress, and challenge stress. In order to test the moderator effect of problem-focused coping and emotion-fo...

On the structure and spin states of Fe(III)-EDDHA complexes.

Science.gov (United States)

Gómez-Gallego, Mar; Fernández, Israel; Pellico, Daniel; Gutiérrez, Angel; Sierra, Miguel A; Lucena, Juan J

2006-07-10

DFT methods are suitable for predicting both the geometries and spin states of EDDHA-Fe(III) complexes. Thus, extensive DFT computational studies have shown that the racemic-Fe(III) EDDHA complex is more stable than the meso isomer, regardless of the spin state of the central iron atom. A comparison of the energy values obtained for the complexes under study has also shown that high-spin (S = 5/2) complexes are more stable than low-spin (S = 1/2) ones. These computational results matched the experimental results of the magnetic susceptibility values of both isomers. In both cases, their behavior has been fitted as being due to isolated high-spin Fe(III) in a distorted octahedral environment. The study of the correlation diagram also confirms the high-spin iron in complex 2b. The geometry optimization of these complexes performed with the standard 3-21G* basis set for hydrogen, carbon, oxygen, and nitrogen and the Hay-Wadt small-core effective core potential (ECP) including a double-xi valence basis set for iron, followed by single-point energy refinement with the 6-31G* basis set, is suitable for predicting both the geometries and the spin-states of EDDHA-Fe(III) complexes. The presence of a high-spin iron in Fe(III)-EDDHA complexes could be the key to understanding their lack of reactivity in electron-transfer processes, either chemically or electrochemically induced, and their resistance to photodegradation.

The Common Core State Standards' Quantitative Text Complexity Trajectory: Figuring out How Much Complexity Is Enough

Science.gov (United States)

Williamson, Gary L.; Fitzgerald, Jill; Stenner, A. Jackson

2013-01-01

The Common Core State Standards (CCSS) set a controversial aspirational, quantitative trajectory for text complexity exposure for readers throughout the grades, aiming for all high school graduates to be able to independently read complex college and workplace texts. However, the trajectory standard is presented without reference to how the…

Influence of thyroid states on stress gastric ulcer formation

Energy Technology Data Exchange (ETDEWEB)

Hernandez, D.E.; Walker, C.H.; Mason, G.A.

1988-01-01

This study was designed to test the hypothesis that thyroid states may affect the acute development of gastric lesions induced by cold-resistant stress. Normal (euthyroid), hyperthyroid and hypothyroid rats were used. Gastric lesion incidence and severity was significantly increased in hypothyroid rats, whereas in contrast hyperthyroid rats developed significantly less gastric lesions. As anticipated, plasma levels of thyroxin (T/sub 4/) were significantly elevated in hyperthyroid rats, and undetectable in hypothyroid rats. Acute pretreatment with i.p. cimetidine, but not T/sub 4/ 1 h prior to stress completely prevented gastric lesions formation in hypothyroid rats. Finally, binding of /sup 3/H-dihydroalprenolol to ..beta..-adrenergic receptors on brain membranes prepared from frontal cortex was reduced by 20% in hypothyroid rats after 3 h of stress. These and other data contained herein suggest that thyroid hormones contribute to modulate the responsiveness of the gastric mucosa to stress. The increase rate of ulcerogenesis observed in hypothyroid rats appears to be mediated by gastric acid secretion. The central mechanism for this response may involve decreased brain nonadrenergic receptor function.

Influence of thyroid states on stress gastric ulcer formation

International Nuclear Information System (INIS)

Hernandez, D.E.; Walker, C.H.; Mason, G.A.

1988-01-01

This study was designed to test the hypothesis that thyroid states may affect the acute development of gastric lesions induced by cold-resistant stress. Normal (euthyroid), hyperthyroid and hypothyroid rats were used. Gastric lesion incidence and severity was significantly increased in hypothyroid rats, whereas in contrast hyperthyroid rats developed significantly less gastric lesions. As anticipated, plasma levels of thyroxin (T 4 ) were significantly elevated in hyperthyroid rats, and undetectable in hypothyroid rats. Acute pretreatment with i.p. cimetidine, but not T 4 1 h prior to stress completely prevented gastric lesions formation in hypothyroid rats. Finally, binding of 3 H-dihydroalprenolol to β-adrenergic receptors on brain membranes prepared from frontal cortex was reduced by 20% in hypothyroid rats after 3 h of stress. These and other data contained herein suggest that thyroid hormones contribute to modulate the responsiveness of the gastric mucosa to stress. The increase rate of ulcerogenesis observed in hypothyroid rats appears to be mediated by gastric acid secretion. The central mechanism for this response may involve decreased brain nonadrenergic receptor function

Opposite effects of glucocorticoid receptor activation on hippocampal CA1 dendritic complexity in chronically stressed and handled animals

NARCIS (Netherlands)

Alfarez, D.N.; Karst, H.; Velzing, E.H.; Joëls, M.; Krugers, H.J.

2008-01-01

Remodeling of synaptic networks is believed to contribute to synaptic plasticity and long-term memory performance, both of which are modulated by chronic stress. We here examined whether chronic stress modulates dendritic complexity of hippocampal CA1 pyramidal cells, under conditions of basal as

Pattern Driven Stress Localization

Science.gov (United States)

Croll, Andrew; Crosby, Alfred

2010-03-01

The self-assembly of patterns from isotropic initial states is a major driver of modern soft-matter research. This avenue of study is directed by the desire to understand the complex physics of the varied structures found in Nature, and by technological interest in functional materials that may be derived through biomimicry. In this work we show how a simple striped phase can respond with significant complexity to an appropriately chosen perturbation. In particular, we show how a buckled elastic plate transitions into a state of stress localization using a simple, self-assembled variation in surface topography. The collection of topographic boundaries act in concert to change the state from isotropic sinusoidal wrinkles, to sharp folds or creases separated by relatively flat regions. By varying the size of the imposed topographic pattern or the wavelength of the wrinkles, we construct a state diagram of the system. The localized state has implications for both biological systems, and for the control of non-linear pattern formation.

Investigations on the influence of the stress state on fracture-mechanical values

International Nuclear Information System (INIS)

Schmidt, P.

1979-01-01

Fracture toughness obtained from specimen can be applied to construction elements only when the same stress state exists. In standardised fracture-mechanical tests plain strain is realised. Using the stress intensity factor, a critical crack length or a critical load can be obtained. Above these values a crack propagates in an unstable way. The specimen are tested under uni-axial load. In this paper investigations have been made whether a biaxial load increases the stress state over the plain strain and whether consequently a decrease of the critical fracture toughness and a shift of the temperatures Tsub(g)sub(y) and Tsub(s) results which characterise the fracture behaviour of steel. In order to answer these questions the tests were made which induced due to their geometry an additional nominal stress parallel to the crack front in spite of uni-axial loading. The results were compared with those from specimen without an additional nominal stress and having in their cross section under same test conditions nearly the same plain strain. The fracture toughness of both specimen types were compared at temperatures between 142 K and 252 K and correlated to other material-characterising values. The tests were completed by stress analysis and by comparing the crack opening displacement. Due to the additional stress, Tsub(g)sub(y) was found to be 20 K higher than for the reference specimen. The fracture toughness decreases significantly in certain temperature ranges. The plastic stress concentration factor was comperatively higher and the remaining plastic crack opening decreases up to 25%. (orig.) [de

Visualizing the Arithmetic of Complex Numbers

Science.gov (United States)

Soto-Johnson, Hortensia

2014-01-01

The Common Core State Standards Initiative stresses the importance of developing a geometric and algebraic understanding of complex numbers in their different forms (i.e., Cartesian, polar and exponential). Unfortunately, most high school textbooks do not offer such explanations much less exercises that encourage students to bridge geometric and…

Failure of Sierra White granite under general states of stress

Science.gov (United States)

Ingraham, M. D.; Dewers, T. A.; Lee, M.; Holdman, O.; Cheung, C.; Haimson, B. C.

2017-12-01

The effect of the intermediate principal stress on the failure of Sierra White granite was investigated by performing tests under true triaxial states of stress. Tests were performed under constant Lode angle conditions with Lode angles ranging from 0 to 30°, pure shear to axisymmetric compression. Results show that the failure of Sierra White granite is heavily dependent on the intermediate principal stress which became more dramatic as the mean stress increased. An analysis of the shear bands formed at failure was performed using an associated flow rule and the Rudnicki and Rice (1975) localization criteria. The localization analysis showed excellent agreement with experimental results. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia LLC, a wholly owned subsidiary of Honeywell International Inc. for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525.

Efficient growth of complex graph states via imperfect path erasure

International Nuclear Information System (INIS)

Campbell, Earl T; Fitzsimons, Joseph; Benjamin, Simon C; Kok, Pieter

2007-01-01

Given a suitably large and well connected (complex) graph state, any quantum algorithm can be implemented purely through local measurements on the individual qubits. Measurements can also be used to create the graph state: path erasure techniques allow one to entangle multiple qubits by determining only global properties of the qubits. Here, this powerful approach is extended by demonstrating that even imperfect path erasure can produce the required graph states with high efficiency. By characterizing the degree of error in each path erasure attempt, one can subsume the resulting imperfect entanglement into an extended graph state formalism. The subsequent growth of the improper graph state can be guided, through a series of strategic decisions, in such a way as to bound the growth of the error and eventually yield a high-fidelity graph state. As an implementation of these techniques, we develop an analytic model for atom (or atom-like) qubits in mismatched cavities, under the double-heralding entanglement procedure of Barrett and Kok (2005 Phys. Rev. A 71 060310). Compared to straightforward post-selection techniques our protocol offers a dramatic improvement in growing complex high-fidelity graph states

Parameter and State Estimation of Large-Scale Complex Systems Using Python Tools

Directory of Open Access Journals (Sweden)

M. Anushka S. Perera

2015-07-01

Full Text Available This paper discusses the topics related to automating parameter, disturbance and state estimation analysis of large-scale complex nonlinear dynamic systems using free programming tools. For large-scale complex systems, before implementing any state estimator, the system should be analyzed for structural observability and the structural observability analysis can be automated using Modelica and Python. As a result of structural observability analysis, the system may be decomposed into subsystems where some of them may be observable --- with respect to parameter, disturbances, and states --- while some may not. The state estimation process is carried out for those observable subsystems and the optimum number of additional measurements are prescribed for unobservable subsystems to make them observable. In this paper, an industrial case study is considered: the copper production process at Glencore Nikkelverk, Kristiansand, Norway. The copper production process is a large-scale complex system. It is shown how to implement various state estimators, in Python, to estimate parameters and disturbances, in addition to states, based on available measurements.

Mozart versus new age music: relaxation states, stress, and ABC relaxation theory.

Science.gov (United States)

Smith, Jonathan C; Joyce, Carol A

2004-01-01

Smith's (2001) Attentional Behavioral Cognitive (ABC) relaxation theory proposes that all approaches to relaxation (including music) have the potential for evoking one or more of 15 factor-analytically derived relaxation states, or "R-States" (Sleepiness, Disengagement, Rested / Refreshed, Energized, Physical Relaxation, At Ease/Peace, Joy, Mental Quiet, Childlike Innocence, Thankfulness and Love, Mystery, Awe and Wonder, Prayerfulness, Timeless/Boundless/Infinite, and Aware). The present study investigated R-States and stress symptom-patterns associated with listening to Mozart versus New Age music. Students (N = 63) were divided into three relaxation groups based on previously determined preferences. Fourteen listened to a 28-minute tape recording of Mozart's Eine Kleine Nachtmusik and 14 listened to a 28-minute tape of Steven Halpern's New Age Serenity Suite. Others (n = 35) did not want music and instead chose a set of popular recreational magazines. Participants engaged in their relaxation activity at home for three consecutive days for 28 minutes a session. Before and after each session, each person completed the Smith Relaxation States Inventory (Smith, 2001), a comprehensive questionnaire tapping 15 R-States as well as the stress states of somatic stress, worry, and negative emotion. Results revealed no differences at Session 1. At Session 2, those who listened to Mozart reported higher levels of At Ease/Peace and lower levels of Negative Emotion. Pronounced differences emerged at Session 3. Mozart listeners uniquely reported substantially higher levels of Mental Quiet, Awe and Wonder, and Mystery. Mozart listeners reported higher levels, and New Age listeners slightly elevated levels, of At Ease/Peace and Rested/Refreshed. Both Mozart and New Age listeners reported higher levels of Thankfulness and Love. In summary, those who listened to Mozart's Eine Kleine Nachtmusik reported more psychological relaxation and less stress than either those who listened to

Psychological distress and stressful life events in pediatric complex regional pain syndrome

Science.gov (United States)

Wager, Julia; Brehmer, Hannah; Hirschfeld, Gerrit; Zernikow, Boris

2015-01-01

BACKGROUND: There is little knowledge regarding the association between psychological factors and complex regional pain syndrome (CRPS) in children. Specifically, it is not known which factors precipitate CRPS and which result from the ongoing painful disease. OBJECTIVES: To examine symptoms of depression and anxiety as well as the experience of stressful life events in children with CRPS compared with children with chronic primary headaches and functional abdominal pain. METHODS: A retrospective chart study examined children with CRPS (n=37) who received intensive inpatient pain treatment between 2004 and 2010. They were compared with two control groups (chronic primary headaches and functional abdominal pain; each n=37), who also received intensive inpatient pain treatment. Control groups were matched with the CRPS group with regard to admission date, age and sex. Groups were compared on symptoms of depression and anxiety as well as stressful life events. RESULTS: Children with CRPS reported lower anxiety and depression scores compared with children with abdominal pain. A higher number of stressful life events before and after the onset of the pain condition was observed for children with CRPS. CONCLUSIONS: Children with CRPS are not particularly prone to symptoms of anxiety or depression. Importantly, children with CRPS experienced more stressful life events than children with chronic headaches or abdominal pain. Prospective long-term studies are needed to further explore the potential role of stressful life events in the etiology of CRPS. PMID:26035287

STRESS MODELING IN COMPOSITE PRODUCTS USING STANDARD OPTICALLY SENSITIVE MATERIAL

Directory of Open Access Journals (Sweden)

Elifkhan K. Agakhanov

2017-01-01

Full Text Available Abstract. Objectives The problem of physically modelling stresses in a compound solid body of revolution having a complex shape and with a complex load distribution is considered. According to the similarity criteria of stress, deformations and displacements from the volume forces decrease proportionally to the scale of similarity of geometric dimensions, which complicates their direct modelling by the photoelasticity method typically using models made from epoxy materials. Methods Based on the principle of the independent action of the forces, the initial problem is represented as the sum of two problems. In the first uniform problem, the stresses in the body of revolution from the centrifugal forces are simulated by the conventional “freezing” method. In order to solve the second nonuniform problem, the stresses in the region of the model, corresponding to the acting centrifugal forces, are “frozen”. The models are glued in a natural state at room temperature, and the compound model is annealed. Results The band patterns in sections as well as components of radial, tangential and axial stresses on contours and in sections of models are obtained by the methods of normal transmission and numerical integration of the equilibrium equation. According to the modelling criteria, the formula for the transition from stresses in models to stresses in the natural structure is established. The results of the analysis of the effect of a body's material density ratio on the stress state of the entire structure are obtained. Conclusion  Axial stresses have insignificant value as compared to radial and tangential stresses; in addition, the ratio of the densities of the compound body has both a quantitative and qualitative influence on the stress state of the structure.

Quantum Query Complexity for Searching Multiple Marked States from an Unsorted Database

International Nuclear Information System (INIS)

Shang Bin

2007-01-01

An important and usual sort of search problems is to find all marked states from an unsorted database with a large number of states. Grover's original quantum search algorithm is for finding single marked state with uncertainty, and it has been generalized to the case of multiple marked states, as well as been modified to find single marked state with certainty. However, the query complexity for finding all multiple marked states has not been addressed. We use a generalized Long's algorithm with high precision to solve such a problem. We calculate the approximate query complexity, which increases with the number of marked states and with the precision that we demand. In the end we introduce an algorithm for the problem on a 'duality computer' and show its advantage over other algorithms.

Modeling of residual stress state in turning of 304L

International Nuclear Information System (INIS)

Valiorgue, F.; Rech, J.; Bergheau, J.M.

2010-01-01

Research presented in this paper aims to link machining parameters to residual stress state and helps understanding mechanisms responsible of machined surface properties modifications. The first presented works are based on an experimental campaign. They reproduce the finishing turning operation of 304L and allow observing the residual stress state evolution at the work piece surface and for an affected depth of 0.2 mm for such processes. Then, the finishing turning operation is simulated numerically in order to realize the same sensitivity study to cutting parameters. This simulation is based on an hybrid approach mixing experimental data and numerical simulation. This method allows getting round the classical difficulties of turning simulation by applying equivalent thermo mechanical loadings onto the work piece surface without modeling the material separation phenomena. Moreover the numerical model uses an hardening law taking into account dynamic recrystallization phenomena. (authors)

Personal determinants of positive states and stress in psychology students

Directory of Open Access Journals (Sweden)

G.S. Kozhukhar

2013-07-01

Full Text Available We report study results of personality characteristics as predictors of positive states (active, optimistic, emotional, subjective comfort and stress experience in adults with one higher education and ongoing training in Psychology. The respondents were 107 people aged 23 to 52 years. Diagnostic methods we used were: "SMIL" (L. Sobchik, Optimism and Activity Scale (adapted by E. Vodopyanova, C. Izard Differential Emotions Scale (adapted by A. Leonova, Subjective Comfort Scale (adapted by A. Leonova, PSM-25 Scale by Lemyr-Tessier-Fillion. The regression analysis revealed that in subjects ongoing training in Psychology, basic predictor of positive emotions and stress experience is anxiety. Cluster analysis revealed three types of subjects by their positive states experiences, which differ primarily by the level of baseline anxiety and related personality characteristics. The group of risk comprised Psychology students with a tendency to depression and negative emotions and specific personality profile.

State analysis requirements database for engineering complex embedded systems

Science.gov (United States)

Bennett, Matthew B.; Rasmussen, Robert D.; Ingham, Michel D.

2004-01-01

It has become clear that spacecraft system complexity is reaching a threshold where customary methods of control are no longer affordable or sufficiently reliable. At the heart of this problem are the conventional approaches to systems and software engineering based on subsystem-level functional decomposition, which fail to scale in the tangled web of interactions typically encountered in complex spacecraft designs. Furthermore, there is a fundamental gap between the requirements on software specified by systems engineers and the implementation of these requirements by software engineers. Software engineers must perform the translation of requirements into software code, hoping to accurately capture the systems engineer's understanding of the system behavior, which is not always explicitly specified. This gap opens up the possibility for misinterpretation of the systems engineer's intent, potentially leading to software errors. This problem is addressed by a systems engineering tool called the State Analysis Database, which provides a tool for capturing system and software requirements in the form of explicit models. This paper describes how requirements for complex aerospace systems can be developed using the State Analysis Database.

Be Cool with Academic Stress: The Association between Emotional States and Regulatory Strategies among Chinese Adolescents

Science.gov (United States)

Sang, Biao; Pan, Tingting; Deng, Xinmei; Zhao, Xu

2018-01-01

Numerous studies have suggested that academic stress has negative impact on adolescents' psychological function, few of those studies, however, considered whether and how the impact of stress on adolescents' emotional states is moderated by corresponding regulation. This study aimed to examine the fluctuation of emotional states before and after…

Moessbauer spectroscopy-nuclear hyperfine technique for studying dynamic chemical states of iron complexes

International Nuclear Information System (INIS)

Maeda, Y.

2005-01-01

A brief introduction of Moessbauer spectroscopy will be presented, followed by a discussion of the Moessbauer parameters, isomer shifts, quadrupole splittings, and spectral shapes of complexes in the presence of relaxation of the electronic states of the iron atoms. The usefulness of Moessbauer spectroscopy to demonstrate the dynamic phenomena of electronic states will be discussed in this lecture. (1) The Moessbauer spectra of mixed valence dinuclear and trinuclear iron complexes will be discussed in connection with the chemical structure of the complexes: The values of the quadrupole splittings and isomer shifts of [Fe II Fe III (bpmp) (ppa) 2 ](BF 4 ) 2 increase on raising the temperature, where Hbpmp represents 2,6-bis[bis(2- pyridylmethyl)aminoethyl]-4-methylphenol and ppa is 3-n-phenylpropionic acid. The spectra can be accounted for by postulating intramolecular electron exchange between two energetically inequivalent vibronic states Fe A 2+ Fe B 3+ and Fe A 3+ Fe B 2+ : The apparent time averaged valence states of the iron atoms are 2.2 and 2.8 on the Moessbauer time scale at 293 K. (2) The Moessbauer spectra of iron(III) spin-crossover complexes will be discussed in connection with the spin-transition rate and chemical structure of the complexes. The Moessbauer spectra of spin-crossover iron(III) complexes with LIESST (Light Induced Electronic Spin-State Transition) and of metallomesogens will be discussed to illustrate the extension of this research area by the use of Moessbauer spectroscopy.

Predicting stabilizing treatment outcomes for complex posttraumatic stress disorder and dissociative identity disorder: an expertise-based prognostic model

NARCIS (Netherlands)

Baars, E.W.; van der Hart, O.; Nijenhuis, E.R.S.; Chu, J.A.; Glas, G.; Draaijer, N.

2011-01-01

The purpose of this study was to develop an expertise-based prognostic model for the treatment of complex posttraumatic stress disorder (PTSD) and dissociative identity disorder (DID).We developed a survey in 2 rounds: In the first round we surveyed 42 experienced therapists (22 DID and 20 complex

Cadmium stress assessment based on the electrocardiogram characteristics of zebra fish (Danio rerio): QRS complex could play an important role.

Science.gov (United States)

Xing, Na; Ji, Lizhen; Song, Jie; Ma, Jingchun; Li, Shangge; Ren, Zongming; Xu, Fei; Zhu, Jianping

2017-10-01

The electrocardiogram (ECG) of zebra fish (Danio rerio) expresses cardiac features that are similar to humans. Here we use sharp microelectrode measurements to obtain ECG characteristics in adult zebra fish and analyze the effects of cadmium chloride (CdCl 2 ) on the heart. We observe the overall changes of ECG parameters in different treatments (0.1 TU, 0.5 TU and 1.0 TU CdCl 2 ), including P wave, Q wave, R wave, S wave, T wave, PR interval (atrial contraction), QRS complex (ventricular depolarization), ST segment, and QT interval (ventricular repolarization). The trends of the ECG parameters showed some responses to the concentration and exposure time of CdCl 2 , but it was difficult to obtain more information about the useful indicators in water quality assessment depending on tendency analysis alone. A self-organizing map (SOM) showed that P values, R values, and T values were similar; R wave and T wave amplitude were similar; and most important, QRS value was similar to the CdCl 2 stress according to the classified data patterns including CdCl 2 stress (E) and ECG components based on the Ward linkage. It suggested that the duration of QRS complex was related to environmental stress E directly. The specification and evaluation of ECG parameters in Cd 2+ pollution suggested that there is a markedly significant correlation between QRS complex and CdCl 2 stress with the highest r (0.729) and the smallest p (0.002) among all ECG characteristics. In this case, it is concluded that QRS complex can be used as an indicator in the CdCl 2 stress assessment due to the lowest AIC data abased on the linear regression model between the CdCl 2 stress and ECG parameters. Copyright © 2017 Elsevier B.V. All rights reserved.

Local Stress States and Microstructural Damage Response Associated with Deformation Twins in Hexagonal Close Packed Metals

Directory of Open Access Journals (Sweden)

Indranil Basu

2017-12-01

Full Text Available The current work implements a correlative microscopy method utilizing electron back scatter diffraction, focused ion beam and digital image correlation to accurately determine spatially resolved stress profiles in the vicinity of grain/twin boundaries and tensile deformation twin tips in commercially pure titanium. Measured local stress gradients were in good agreement with local misorientation values. The role of dislocation-boundary interactions on the buildup of local stress gradients is elucidated. Stress gradients across the twin-parent interface were compressive in nature with a maximum stress magnitude at the twin boundary. Stress profiles near certain grain boundaries initially display a local stress minimum, followed by a typically observed “one over square root of distance” variation, as was first postulated by Eshelby, Frank and Nabarro. The observed trends allude to local stress relaxation mechanisms very close to the grain boundaries. Stress states in front of twin tips showed tensile stress gradients, whereas the stress state inside the twin underwent a sign reversal. The findings highlight the important role of deformation twins and their corresponding interaction with grain boundaries on damage nucleation in metals.

A review of creep analysis and design under multi-axial stress states

International Nuclear Information System (INIS)

Yao, H.-T.; Xuan Fuzhen; Wang Zhengdong; Tu Shantung

2007-01-01

The existence of multi-axial states of stress cannot be avoided in elevated temperature components. It is essential to understand the associated failure mechanisms and to predict the lifetime in practice. Although metal creep has been studied for about 100 years, many problems are still unsolved, in particular for those involving multi-axial stresses. In this work, a state-of-the-art review of creep analysis and engineering design is carried out, with particular emphasis on the effect of multi-axial stresses. The existing theories and creep design approaches are grouped into three categories, i.e., the classical plastic theory (CPT) based approach, the cavity growth mechanism (CGM) based approach and the continuum damage mechanics (CDM) based approach. Following above arrangements, the constitutive equations and design criteria are addressed. In the end, challenges on the precise description of the multi-axial creep behavior and then improving the strength criteria in engineering design are presented

Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.

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Pitcher, Mark H; Gonzalez-Cano, Rafael; Vincent, Kathleen; Lehmann, Michael; Cobos, Enrique J; Coderre, Terence J; Baeyens, José M; Cervero, Fernando

2017-06-01

Visceral pain has a greater emotional component than somatic pain. To determine if the stress-induced analgesic response is differentially expressed in visceral versus somatic pain states, we studied the effects of a mild social stressor in either acute visceral or somatic pain states in mice. We show that the presence of an unfamiliar conspecific mouse (stranger) in an adjacent cubicle of a standard transparent observation box produced elevated plasma corticosterone levels compared with mice tested alone, suggesting that the mere presence of a stranger is stressful. We then observed noxious visceral or somatic stimulation-induced nociceptive behavior in mice tested alone or in mildly stressful conditions (ie, beside an unfamiliar stranger). Compared with mice tested alone, the presence of a stranger produced a dramatic opioid-dependent reduction in pain behavior associated with visceral but not somatic pain. This social stress-induced reduction of visceral pain behavior relied on visual but not auditory/olfactory cues. These findings suggest that visceral pain states may provoke heightened responsiveness to mild stressors, an effect that could interfere with testing outcomes during simultaneous behavioral testing of multiple rodents. In mice, mild social stress due to the presence of an unfamiliar conspecific mouse reduces pain behavior associated with noxious visceral but not somatic stimulation, suggesting that stress responsiveness may be enhanced in visceral pain versus somatic pain states. Published by Elsevier Inc.

Stress assessment in piping under synthetic thermal loads emulating turbulent fluid mixing

Energy Technology Data Exchange (ETDEWEB)

Costa Garrido, Oriol, E-mail: oriol.costa@ijs.si; El Shawish, Samir, E-mail: samir.elshawish@ijs.si; Cizelj, Leon, E-mail: leon.cizelj@ijs.si

2015-03-15

Highlights: • Generation of complex space-continuous and time-dependent temperature fields. • 1D and 3D thermo-mechanical analyses of pipes under complex surface thermal loads. • Surface temperatures and stress fluctuations are highly linearly correlated. • 1D and 3D results agree for a wide range of Fourier and Biot numbers. • Global thermo-mechanical loading promotes non-equibiaxial stress state. - Abstract: Thermal fatigue assessment of pipes due to turbulent fluid mixing in T-junctions is a rather difficult task because of the existing uncertainties and variability of induced thermal stresses. In these cases, thermal stresses arise on three-dimensional pipe structures due to complex thermal loads, known as thermal striping, acting at the fluid-wall interface. A recently developed approach for the generation of space-continuous and time-dependent temperature fields has been employed in this paper to reproduce fluid temperature fields of a case study from the literature. The paper aims to deliver a detailed study of the three-dimensional structural response of piping under the complex thermal loads arising in fluid mixing in T-junctions. Results of three-dimensional thermo-mechanical analyses show that fluctuations of surface temperatures and stresses are highly linearly correlated. Also, surface stress fluctuations, in axial and hoop directions, are almost equi-biaxial. These findings, representative on cross sections away from system boundaries, are moreover supported by the sensitivity analysis of Fourier and Biot numbers and by the comparison with standard one-dimensional analyses. Agreement between one- and three-dimensional results is found for a wide range of studied parameters. The study also comprises the effects of global thermo-mechanical loading on the surface stress state. Implemented mechanical boundary conditions develop more realistic overall system deformation and promote non-equibiaxial stresses.

FEA stress analysis considering cavity formation of metallic fuel pin under transient state

Energy Technology Data Exchange (ETDEWEB)

Jung, Hyun-Woo; Oh, Young-Ryun; Kim, Yun-Jae [Korea University, Seoul (Korea, Republic of)

2016-05-15

The aim of this research is to study the stress state of the fuel and the cladding under transient state using the commercial finite element analysis software, ABAQUS v6.13. It is checked out that the gap distance between the fuel and the cladding is a major factor determining FCMI stress. In this regard, initial boundary condition of the fuel pin such as the initial gap distance should be set carefully when the stress analysis of the fuel pin under transient state is conducted. In case of simulating cavity formation, it is confirmed that the new cavity simulation model that elements in cavity region lose their stiffness is valid. There is a great deal of research into SFR, which is one of GEN IV reactors. When it comes to the accidents of SFR, there are two cases of accident process. One of them is In-pin process that molten fuel is discharged into upper plenum. The other is Ex-pin process that the molten fuel is discharged into coolant because of breakage of cladding.

Investigation of smooth specimen scc test procedures; variations in environment, specimen size, stressing frame, and stress state. [for high strength aluminum alloys

Science.gov (United States)

Lifka, B. W.; Sprowls, D. O.; Kelsey, R. A.

1975-01-01

The variables studied in the stress-corrosion cracking performance of high strength aluminum alloys were: (1) corrosiveness of the environment, (2) specimen size and stiffness of the stressing system, (3) interpretation of transgranular cracking, and (4) interaction of the state of stress and specimen orientation in a product with an anisotropic grain structure. It was shown that the probability of failure and time to fracture for a specimen loaded in direct tension are influenced by corrosion pattern, the stressing assembly stiffness, and the notch tensile strength of the alloy. Results demonstrate that the combination of a normal tension stress and a shear stress acting on the plane of maximum susceptibility in a product with a highly directional grain cause the greatest tendency for stress-corrosion cracking.

Chronic stress does not impair liver regeneration in rats

DEFF Research Database (Denmark)

Andersen, Kasper J; Knudsen, Anders Riegels; Wiborg, Ove

2015-01-01

a 70 % partial hepatectomy (PHx). The animals were evaluated on postoperative day 2 or 4. Blood samples were collected to examine circulating markers of inflammation and liver cell damage. Additionally, liver tissues were sampled to evaluate liver weight and regeneration rate. RESULTS: None......BACKGROUND: Although wound healing is a simple regenerative process that is critical after surgery, it has been shown to be impaired under psychological stress. The liver has a unique capacity to regenerate through highly complex mechanisms. The aim of this study was to investigate the effects...... of chronic stress, which may induce a depression-like state, on the complex process of liver regeneration in rats. METHODS: Twenty rats were included in this study. The animals received either a standard housing protocol or were subjected to a Chronic Mild Stress (CMS) stress paradigm. All rats underwent...

Profile of mood states and stress-related biochemical indices in long-term yoga practitioners

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Sudo Nobuyuki

2011-06-01

Full Text Available Abstract Background Previous studies have shown the short-term or intermediate-term practice of yoga to be useful for ameliorating several mental disorders and psychosomatic disorders. However, little is known about the long-term influences of yoga on the mental state or stress-related biochemical indices. If yoga training has a stress-reduction effect and also improves an individual's mental states for a long time, long-term yoga practitioners may have a better mental state and lower stress-related biochemical indices in comparison to non-experienced participants. This study simultaneously examined the differences in mental states and urinary stress-related biochemical indices between long-term yoga practitioners and non-experienced participants. Methods The participants were 38 healthy females with more than 2 years of experience with yoga (long-term yoga group and 37 age-matched healthy females who had not participated in yoga (control group. Their mental states were assessed using the Profile of Mood States (POMS questionnaire. The level of cortisol, 8-hydroxydeoxyguanosine (8-OHdG and biopyrrin in urine were used as stress-related biochemical indices. Results The average self-rated mental disturbance, tension-anxiety, anger-hostility, and fatigue scores of the long-term yoga group were lower than those of the control group. There was a trend toward a higher vigor score in the long-term yoga group than that in the control group. There were no significant differences in the scores for depression and confusion in the POMS between the two groups. The urine 8-OHdG concentration showed a trend toward to being lower in the long-term yoga group in comparison to the control group. There were no significant differences in the levels of urine biopyrrin or cortisol. Conclusions The present findings suggest that long-term yoga training can reduce the scores related to mental health indicators such as self-rated anxiety, anger, and fatigue.

Complex trauma and mental health in children and adolescents placed in foster care: findings from the National Child Traumatic Stress Network.

Science.gov (United States)

Greeson, Johanna K P; Briggs, Ernestine C; Kisiel, Cassandra L; Layne, Christopher M; Ake, George S; Ko, Susan J; Gerrity, Ellen T; Steinberg, Alan M; Howard, Michael L; Pynoos, Robert S; Fairbank, John A

2011-01-01

Many children in the child welfare system (CWS) have histories of recurrent interpersonal trauma perpetrated by caregivers early in life often referred to as complex trauma. Children in the CWS also experience a diverse range of reactions across multiple areas of functioning that are associated with such exposure. Nevertheless, few CWSs routinely screen for trauma exposure and associated symptoms beyond an initial assessment of the precipitating event. This study examines trauma histories, including complex trauma exposure (physical abuse, sexual abuse, emotional abuse, neglect, domestic violence), posttraumatic stress, and behavioral and emotional problems of 2,251 youth (age 0 to 21; M = 9.5, SD = 4.3) in foster care who were referred to a National Child Traumatic Stress Network site for treatment. High prevalence rates of complex trauma exposure were observed: 70.4% of the sample reported at least two of the traumas that constitute complex trauma; 11.7% of the sample reported all 5 types. Compared to youth with other types of trauma, those with complex trauma histories had significantly higher rates of internalizing problems, posttraumatic stress, and clinical diagnoses, and differed on some demographic variables. Implications for child welfare practice and future research are discussed.

Interpretation of the Haestholmen in situ state of stress based on core damage observations

International Nuclear Information System (INIS)

Hakala, M.

2000-01-01

At the Haestholmen investigation site, direct in situ stress measurements, overcoring and hydraulic fracturing have been unsuccessful because of ring disking and horizontal hydraulic fracturing. Prior to this study, a detailed study on both core disking and ring disking was made, and based on those results an in situ state of stress interpretation method was developed. In this work this method is applied to the Haestholmen site. The interpretation is based on disk fracture type, spacing and shape. Also, the Hoek-Brown strength envelope and Poisson's ratio of intact rock are needed. The interpretation result is most reliable if both core disking and ring disking information at the same depth levels is available. A detailed core logging showed that ring disking is systematic below the -365 m level in the vertical overcoring stress measurement hole, HH-KR6. On the other hand, no representative core disking exists except for two points in two differently oriented subvertical boreholes HH-KR2 and HHKR7. Because the interpretation has to be based on ring disking only, upper and lower estimates for the vertical stress were set. These were gravitational and 67% of gravitational. Furthermore, the in situ stress state was assumed to be in horizontal and vertical planes, because the disking in vertical borehole HH-KR6 was not inclined. The interpretation resulted in a good estimate for the major horizontal stress but none of the horizontal stress rations ( 0.25, 0.5, 0.75 and 1.0 ) or vertical stress assumptions studied are clearly more probable the others. At the 500 m level the resulting maximum horizontal stress is 41 MPa. If a linear fit through the zero depth and zero stress point is applied, the maximum horizontal stress gradient is 0.0818 z MPa/m with a standard deviation between 5 and 12 per cent. The orientation of the major horizontal stress is 108 with standard deviation of 21 degrees. The interpreted major horizontal stress state also indicated that systematic

Defects in tor regulatory complexes retard aging and carbonyl/oxidative stress development in yeast Sассharomyces cerevisiae

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B. V. Homza

2014-02-01

Full Text Available TOR signaling pathway first described in yeast S. сerevisiae is the highly conserved regulator of eukaryotic cell growth, aging and stress resistance. The effect of nitrogen sources, in particular amino acids, on the activity of TOR signaling pathway is well studied, however its relation to carbohydrates is poor understood. The aim of the present study is expanding of our understanding of potential role of TOR regulatory complexes in development of carbonyl/oxidative stress that can result from yeast cultivation on glucose and fructose. It has been shown that the level of α-dicarbonyl compounds and protein carbonyl groups increased with time of yeast cultivation and was higher in cells grown on fructose that demonstrated their accelerated aging and carbonyl/oxidative stress development as compared with cells grown on glucose. The strains defective in TOR proteins cultivated in the presence of glucose as well as fructose demonstrated lower markers of the stress and aging than parental strain. Thus these data confirmed the previous conclusion on fructose more potent ability to cause carbonyl/oxidative stress and accelerated aging in S. cerevisiae as compared with glucose. However, defects in TOR regulatory complexes retard aging and development of the stress in yeast independent on the type of carbohydrate in the cultivation medium.

Complex network analysis of resting-state fMRI of the brain.

Science.gov (United States)

Anwar, Abdul Rauf; Hashmy, Muhammad Yousaf; Imran, Bilal; Riaz, Muhammad Hussnain; Mehdi, Sabtain Muhammad Muntazir; Muthalib, Makii; Perrey, Stephane; Deuschl, Gunther; Groppa, Sergiu; Muthuraman, Muthuraman

2016-08-01

Due to the fact that the brain activity hardly ever diminishes in healthy individuals, analysis of resting state functionality of the brain seems pertinent. Various resting state networks are active inside the idle brain at any time. Based on various neuro-imaging studies, it is understood that various structurally distant regions of the brain could be functionally connected. Regions of the brain, that are functionally connected, during rest constitutes to the resting state network. In the present study, we employed the complex network measures to estimate the presence of community structures within a network. Such estimate is named as modularity. Instead of using a traditional correlation matrix, we used a coherence matrix taken from the causality measure between different nodes. Our results show that in prolonged resting state the modularity starts to decrease. This decrease was observed in all the resting state networks and on both sides of the brain. Our study highlights the usage of coherence matrix instead of correlation matrix for complex network analysis.

Nonintrusive biological signal monitoring in a car to evaluate a driver's stress and health state.

Science.gov (United States)

Baek, Hyun Jae; Lee, Haet Bit; Kim, Jung Soo; Choi, Jong Min; Kim, Ko Keun; Park, Kwang Suk

2009-03-01

Nonintrusive monitoring of a driver's physiological signals was introduced and evaluated in a car as a test of extending the concept of ubiquitous healthcare to vehicles. Electrocardiogram, photoplethysmogram, galvanic skin response, and respiration were measured in the ubiquitous healthcare car (U-car) using nonintrusively installed sensors on the steering wheel, driver's seat, and seat belt. Measured signals were transmitted to the embedded computer via Bluetooth(R) communication and processed. We collected and analyzed physiological signals during driving in order to estimate a driver's stress state while using this system. In order to compare the effect of stress on physical and mental conditions, two categories of stresses were defined. Experimental results show that a driver's physiological signals were measured with acceptable quality for analysis without interrupting driving, and they were changed meaningfully due to elicited stress. This nonintrusive monitoring can be used to evaluate a driver's state of health and stress.

Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus.

Science.gov (United States)

Diamantis, Dimitrios A; Ramesova, Sarka; Chatzigiannis, Christos M; Degano, Ilaria; Gerogianni, Paraskevi S; Karadima, Constantina; Perikleous, Sonia; Rekkas, Dimitrios; Gerothanassis, Ioannis P; Galaris, Dimitrios; Mavromoustakos, Thomas; Valsami, Georgia; Sokolova, Romana; Tzakos, Andreas G

2018-06-07

Flavonoids possess a rich polypharmacological profile and their biological role is linked to their oxidation state protecting DNA from oxidative stress damage. However, their bioavailability is hampered due to their poor aqueous solubility. This can be surpassed through encapsulation to supramolecular carriers as cyclodextrin (CD). A quercetin- 2HP-β-CD complex has been formerly reported by us. However, once the flavonoid is in its 2HP-β-CD encapsulated state its oxidation potential, its decomplexation mechanism, its potential to protect DNA damage from oxidative stress remained elusive. To unveil this, an array of biophysical techniques was used. The quercetin-2HP-β-CD complex was evaluated through solubility and dissolution experiments, electrochemical and spectroelectrochemical studies (Cyclic Voltammetry) UV-Vis spectroscopy, HPLC-ESI-MS/MS and HPLC-DAD, fluorescence spectroscopy, NMR Spectroscopy, theoretical calculations (density functional theory (DFT)) and biological evaluation of the protection offered against H 2 O 2 -induced DNA damage. Encapsulation of quercetin inside the supramolecule's cavity enhanced its solubility and oxidation profile is retained in its encapsulated state. Although the protective ability of the quercetin-2HP-β-CD complex against H 2 O 2 was diminished, iron serves as a chemical stimulus to dissociate the complex and release quercetin. We found that in a quercetin-2HP-β-CD inclusion complex quercetin retains its oxidation profile similarly to its native state, while iron can operate as a chemical stimulus to release quercetin from its host cavity. The oxidation profile of a natural product once it is encapsulated in a supramolecular cyclodextrin carrier as also it was discovered that decomplexation can be triggered by a chemical stimulus. Copyright © 2018. Published by Elsevier B.V.

Analysis of Metal Flow Behavior and Residual Stress Formation of Complex Functional Profiles under High-Speed Cold Roll-Beating

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Fengkui Cui

2018-01-01

Full Text Available To obtain a good surface layer performance of the complex functional profile during the high-speed cold roll-beating forming process, this paper analyzed the metal plastic flow and residual stress-formed mechanism by using a theoretical model of the metal flow and residual stress generation. By using simulation software, the cold roll-beating forming process of a spline shaft was simulated and analyzed. The metal flow and residual stress formation law in the motion were researched. In a practical experiment, the changes in the grains in the spline tooth profile section and the residual stress distribution on the tooth profile were studied. A microcorrespondence relationship was established between the metal plastic flow and the residual stress generation. The conclusions indicate that the rate at which the metal flow decreases changes gradually at different metal layers. The residual stress value is directly related to the plastic flow difference. As the roll-beating speed increases, the uneven degree of plastic deformation at the workpiece surface increases, and the residual stress in the tooth profile is generally greater. At the same roll-beating speed, the rate change trend of the metal flow decreases gradually from the surface to the inner layer and from the dedendum to the addendum. The residual stress distribution on the surface of the tooth profile decreases from the dedendum to the addendum. These findings provide a basis and guidance for the controlled use of residual stress, obtaining better surface layer quality in the high-speed cold roll-beating process of the complex functional profile.

Stress-deformed state of cylindrical specimens during indirect tensile strength testing

Directory of Open Access Journals (Sweden)

Levan Japaridze

2015-10-01

Full Text Available In this study, the interaction between cylindrical specimen made of homogeneous, isotropic, and linearly elastic material and loading jaws of any curvature is considered in the Brazilian test. It is assumed that the specimen is diametrically compressed by elliptic normal contact stresses. The frictional contact stresses between the specimen and platens are neglected. The analytical solution starts from the contact problem of the loading jaws of any curvature and cylindrical specimen. The contact width, corresponding loading angle (2θ0, and elliptical stresses obtained through solution of the contact problems are used as boundary conditions for a cylindrical specimen. The problem of the theory of elasticity for a cylinder is solved using Muskhelishvili's method. In this method, the displacements and stresses are represented in terms of two analytical functions of a complex variable. In the main approaches, the nonlinear interaction between the loading bearing blocks and the specimen as well as the curvature of their surfaces and the elastic parameters of their materials are taken into account. Numerical examples are solved using MATLAB to demonstrate the influence of deformability, curvature of the specimen and platens on the distribution of the normal contact stresses as well as on the tensile and compressive stresses acting across the loaded diameter. Derived equations also allow calculating the modulus of elasticity, total deformation modulus and creep parameters of the specimen material based on the experimental data of radial contraction of the specimen.

Stress state in perforated plates

International Nuclear Information System (INIS)

Visner, J.

1977-01-01

The method is described of photoelastic measurement of stress concentration factors (s.c.f) in plates perforated by a square, triangular and diagonal grid of circular holes and loaded by uniaxial or biaxial tensile stress. A loading equipment which was developed and its modifications are described. Stress concentration factors found are compared with theoretical and experimental results given in references. (author)

Probing stress state and phase content in ultra-thin Ta films

International Nuclear Information System (INIS)

Whitacre, J.F.; Yalisove, S.M.; Bilello, J.C.; Rek, Z.U.

1998-01-01

Ta films 25 angstrom to 200 angstrom in thickness were sputter-deposited using different sputter gas (Ar) pressures and cathode power settings. The average in-plane stresses were determined using double crystal diffraction topography (DCDT). X-ray analysis (using the grazing incidence x-ray scattering (GIXS) geometry) was performed using a synchrotron light source. To study microstructure and phase content, transmission electron microscopy (TEM) and transmission electron diffraction (TED) were used. Well resolved x-ray patterns were collected for all of the films. The DCDT stress data was found to be consistent with stress effects evidence in the GIXS data. In general, residual stress state was not strongly dependent upon Ar pressure. The strongest evidence of amorphous content was found in both x-ray and TED data taken from 25 angstrom thick films deposited using 2mTorr Ar pressure and 460 W cathode power. These results show that it is possible to create and study ultra-thin Ta films which possess a range of residual stresses and phase compositions

Safety and observer variability of cardiac magnetic resonance imaging combined with low-dose dobutamine stress-testing in patients with complex congenital heart disease

NARCIS (Netherlands)

Robbers-Visser, D.; Luijnenburg, S.E.; Berg, J. van den; Roos-Hesselink, J.W.; Strengers, J.L.; Kapusta, L.; Moelker, A.; Helbing, W.A.

2011-01-01

BACKGROUND: In patients with complex congenital heart disease (CHD) abnormal ventricular stress responses have been reported with dobutamine stress cardiovascular magnetic resonance (DCMR). These abnormal stress responses are potential indicators of long-term outcome. However, safety and

Evolution of microstructure and residual stress on L1{sub 0} ordering in FePt thin films with different initial stress states

Energy Technology Data Exchange (ETDEWEB)

Hsiao, S.N., E-mail: pmami.hsiao@gmail.com [Department of Materials Science and Engineering, Feng Chia University, Taichung 407, Taiwan (China); Yuan, F.T. [iSentek Ltd., Advanced Sensor Laboratory, New Taipei City 221, Taiwan (China); Chen, S.K. [Department of Materials Science and Engineering, Feng Chia University, Taichung 407, Taiwan (China); Sun, A.C. [Department of Chemical Engineering and Materials Science, Yuan Ze University, Jungli 320, Taiwan (China); Su, S.H.; Chiu, K.F. [Department of Materials Science and Engineering, Feng Chia University, Taichung 407, Taiwan (China)

2016-01-15

We have characterized the dependence of microstructure, and internal strain/stress on L1{sub 0} ordering in 40 nm thick FePt films with different initial stresses. The microstructural and crystallographic results indicate that defect annihilation and grain growth induced an increase in tensile stress of ~1 GPa before extensive L1{sub 0} ordering. The induced tensile stress can efficiently facilitate the nucleation of L1{sub 0} phase owing to that the volume expansion of L1{sub 0} ordering and atomic rearrangement neutralizes the tensile stress. If the as-deposited FePt film has a highly compressive state, the induced tensile stress will be canceled out and ordering is retarded, which results in a higher ordering temperature. - Highlights: • Microstructure-stress connection in FePt films was studied. • Initial stress alters microstructure and stress evolution during annealing. • Densification induces tensile stress of ~1 GPa before extensive L1{sub 0} ordering. • Induced tensile stress can efficiently facilitate the nucleation of L1{sub 0} phase. • Compressively initial stress results in a higher ordering temperature .

Squeezed states and Hermite polynomials in a complex variable

International Nuclear Information System (INIS)

Ali, S. Twareque; Górska, K.; Horzela, A.; Szafraniec, F. H.

2014-01-01

Following the lines of the recent paper of J.-P. Gazeau and F. H. Szafraniec [J. Phys. A: Math. Theor. 44, 495201 (2011)], we construct here three types of coherent states, related to the Hermite polynomials in a complex variable which are orthogonal with respect to a non-rotationally invariant measure. We investigate relations between these coherent states and obtain the relationship between them and the squeezed states of quantum optics. We also obtain a second realization of the canonical coherent states in the Bargmann space of analytic functions, in terms of a squeezed basis. All this is done in the flavor of the classical approach of V. Bargmann [Commun. Pure Appl. Math. 14, 187 (1961)

Childhood trauma and complex posttraumatic stress disorder symptoms in older adults: A study of direct effects and social-interpersonal factors as potential mediators.

Science.gov (United States)

Krammer, Sandy; Kleim, Birgit; Simmen-Janevska, Keti; Maercker, Andreas

2016-01-01

Childhood traumatic events may lead to long-lasting psychological effects and contribute to the development of complex posttraumatic sequelae. These might be captured by the diagnostic concept of complex posttraumatic stress disorder (CPTSD) as an alternative to classic posttraumatic stress disorder (PTSD). CPTSD comprises a further set of symptoms in addition to those of PTSD, namely, changes in affect, self, and interpersonal relationships. Previous empirical research on CPTSD has focused on middle-aged adults but not on older adults. Moreover, predictor models of CPTSD are still rare. The current study investigated the association between traumatic events in childhood and complex posttraumatic stress symptoms in older adults. The mediation of this association by 2 social-interpersonal factors (social acknowledgment as a survivor and dysfunctional disclosure) was investigated. These 2 factors focus on the perception of acknowledgment by others and either the inability to disclose traumatic experiences or the ability to do so only with negative emotional reactions. A total of 116 older individuals (age range = 59-98 years) who had experienced childhood traumatic events completed standardized self-report questionnaires indexing childhood trauma, complex trauma sequelae, social acknowledgment, and dysfunctional disclosure of trauma. The results showed that traumatic events during childhood were associated with later posttraumatic stress symptoms but with classic rather than complex symptoms. Social acknowledgment and dysfunctional disclosure partially mediated this relationship. These findings suggest that childhood traumatic stress impacts individuals across the life span and may be associated with particular adverse psychopathological consequences.

Analysis of Pilot Feedback Regarding the Use of State Awareness Technologies During Complex Situations

Science.gov (United States)

Evans, Emory; Young, Steven D.; Daniels, Taumi; Santiago-Espada, Yamira; Etherington, Tim

2016-01-01

A flight simulation study was conducted at NASA Langley Research Center to evaluate flight deck systems that (1) predict aircraft energy state and/or autoflight configuration, (2) present the current state and expected future state of automated systems, and/or (3) show the state of flight-critical data systems in use by automated systems and primary flight instruments. Four new technology concepts were evaluated vis-à-vis current state-of-the-art flight deck systems and indicators. This human-in-the-loop study was conducted using commercial airline crews. Scenarios spanned a range of complex conditions and several emulated causal factors and complexity in recent accidents involving loss of state awareness by pilots (e.g. energy state, automation state, and/or system state). Data were collected via questionnaires administered after each flight, audio/video recordings, physiological data, head and eye tracking data, pilot control inputs, and researcher observations. This paper strictly focuses on findings derived from the questionnaire responses. It includes analysis of pilot subjective measures of complexity, decision making, workload, situation awareness, usability, and acceptability.

Baseline and post-stress seasonal changes in immunocompetence and redox state maintenance in the fishing bat Myotis vivesi

Science.gov (United States)

Ibáñez-Contreras, Alejandra; Miranda-Labra, Roxana U.; Flores-Martínez, José Juan

2018-01-01

Little is known of how the stress response varies when animals confront seasonal life-history processes. Antioxidant defenses and damage caused by oxidative stress and their link with immunocompetence are powerful biomarkers to assess animal´s physiological stress response. The aim of this study was A) to determine redox state and variation in basal (pre-acute stress) immune function during summer, autumn and winter (spring was not assessed due to restrictions in collecting permit) in the fish-eating Myotis (Myotis vivesi; Chiroptera), and B) to determine the effect of acute stress on immunocompetence and redox state during each season. Acute stress was stimulated by restricting animal movement for 6 and 12 h. The magnitude of the cellular immune response was higher during winter whilst that of the humoral response was at its highest during summer. Humoral response increased after 6 h of movement restriction stress and returned to baseline levels after 12 h. Basal redox state was maintained throughout the year, with no significant changes in protein damage, and antioxidant activity was modulated mainly in relation to variation to environment cues, increasing during high temperatures and decreasing during windy nights. Antioxidant activity increased after the 6 h of stressful stimuli especially during summer and autumn, and to a lesser extent in early winter, but redox state did not vary. However, protein damage increased after 12 h of stress during summer. Prolonged stress when the bat is engaged in activities of high energy demand overcame its capacity to maintain homeostasis resulting in oxidative damage. PMID:29293551

Parenting stress as a mediator of parents' negative mood state and behavior problems in children with newly diagnosed cancer.

Science.gov (United States)

van der Geest, Ivana M; van den Heuvel-Eibrink, Marry M; Passchier, Jan; van den Hoed-Heerschop, Corry; Pieters, Rob; Darlington, Anne-Sophie E

2014-07-01

The aim was to investigate the influence of parents' negative mood state and parenting stress on behavior in children with newly diagnosed cancer. A total of 123 parents (n=58 fathers, n=65 mothers) of 67 children with newly diagnosed cancer completed three questionnaires separately at the same time measuring parents' negative mood state, parenting stress, and child behavior problems. Parents' negative mood state was weakly correlated to more child behavior problems (r=0.31, pparenting stress were strongly correlated to more child behavior problems (r=0.61, pparents' negative mood state and child behavior problems (c=0.29, p=0.02 (fathers); c=0.25, p=0.04 (mothers)) became non-significant after mediating for parenting stress (c'=0.003, p=0.98 (fathers); c'=0.10, p=0.42 (mothers)). The indirect effect of parents' negative mood state and child behavior problems was only significant for fathers (95% CI [0.12; 0.51]), indicating that parenting stress mediates the effect between fathers' negative mood state and child behavior problems. This is the first study to demonstrate the mediational role of parenting stress in fathers of a child with newly diagnosed cancer. Copyright © 2014 John Wiley & Sons, Ltd.

The study of stress-strain state of stabilized layered soil foundations

Directory of Open Access Journals (Sweden)

Sokolov Mikhail V.

2017-01-01

Full Text Available Herein presented are the results of modeling and analysis of stress-strain state of layered inhomogeneous foundation soil when it is stabilised by injection to different depths. Produced qualitative and quantitative analysis of the components of the field of isolines of stresses, strains, stress concentration and the difference between the strain at the boundary of different elastic horizontal layers. Recommendations are given for the location of stabilised zones in relation to the border of different elastic layers. In particular, it found that stabilization of soil within the weak layer is inappropriate, since it practically provides no increase in the stability of the soil foundation, and when performing stabilisation of soil foundations, it is recommended to place the lower border of the stabilisation zone below the border of a stronger layer, at this the distribution of stresses and strains occurs more evenly, and load-bearing capacity of this layer is used to the maximum.

Application of nonlinear ultrasonic method for monitoring of stress state in concrete

International Nuclear Information System (INIS)

Kim, Gyu Jin; Kwak, Hyo Gyoung; Park, Sun Jong

2016-01-01

As the lifespan of concrete structures increases, their load carrying capacity decreases owing to cyclic loads and long-term effects such as creep and shrinkage. For these reasons, there is a necessity for stress state monitoring of concrete members. Particularly, it is necessary to evaluate the concrete structures for behavioral changes by using a technique that can overcome the measuring limitations of usual ultrasonic nondestructive evaluation methods. This paper proposes the use of a nonlinear ultrasonic method, namely, nonlinear resonant ultrasonic spectroscopy (NRUS) for the measurement of nonlinearity parameters for stress monitoring. An experiment compared the use of NRUS method and a linear ultrasonic method, namely, ultrasonic pulse velocity (UPV) to study the effects of continuously increasing loads and cyclic loads on the nonlinearity parameter. Both NRUS and UPV methods found a similar direct relationship between load level and that parameter. The NRUS method showed a higher sensitivity to micro-structural changes of concrete than UPV method. Thus, the experiment confirms the possibility of using the nonlinear ultrasonic method for stress state monitoring of concrete members

Application of nonlinear ultrasonic method for monitoring of stress state in concrete

Energy Technology Data Exchange (ETDEWEB)

Kim, Gyu Jin; Kwak, Hyo Gyoung [Dept. of Civil and Environmental Engineering, Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Park, Sun Jong [Dept. of Structural System and Site Safety Evaluation, Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2016-04-15

As the lifespan of concrete structures increases, their load carrying capacity decreases owing to cyclic loads and long-term effects such as creep and shrinkage. For these reasons, there is a necessity for stress state monitoring of concrete members. Particularly, it is necessary to evaluate the concrete structures for behavioral changes by using a technique that can overcome the measuring limitations of usual ultrasonic nondestructive evaluation methods. This paper proposes the use of a nonlinear ultrasonic method, namely, nonlinear resonant ultrasonic spectroscopy (NRUS) for the measurement of nonlinearity parameters for stress monitoring. An experiment compared the use of NRUS method and a linear ultrasonic method, namely, ultrasonic pulse velocity (UPV) to study the effects of continuously increasing loads and cyclic loads on the nonlinearity parameter. Both NRUS and UPV methods found a similar direct relationship between load level and that parameter. The NRUS method showed a higher sensitivity to micro-structural changes of concrete than UPV method. Thus, the experiment confirms the possibility of using the nonlinear ultrasonic method for stress state monitoring of concrete members.

CDIP1-BAP31 Complex Transduces Apoptotic Signals from Endoplasmic Reticulum to Mitochondria under Endoplasmic Reticulum Stress

Directory of Open Access Journals (Sweden)

Takushi Namba

2013-10-01

Full Text Available Resolved endoplasmic reticulum (ER stress response is essential for intracellular homeostatic balance, but unsettled ER stress can lead to apoptosis. Here, we show that a proapoptotic p53 target, CDIP1, acts as a key signal transducer of ER-stress-mediated apoptosis. We identify B-cell-receptor-associated protein 31 (BAP31 as an interacting partner of CDIP1. Upon ER stress, CDIP1 is induced and enhances an association with BAP31 at the ER membrane. We also show that CDIP1 binding to BAP31 is required for BAP31 cleavage upon ER stress and for BAP31-Bcl-2 association. The recruitment of Bcl-2 to the BAP31-CDIP1 complex, as well as CDIP1-dependent truncated Bid (tBid and caspase-8 activation, contributes to BAX oligomerization. Genetic knockout of CDIP1 in mice leads to impaired response to ER-stress-mediated apoptosis. Altogether, our data demonstrate that the CDIP1/BAP31-mediated regulation of mitochondrial apoptosis pathway represents a mechanism for establishing an ER-mitochondrial crosstalk for ER-stress-mediated apoptosis signaling.

Influence of fatigue crack wake length and state of stress on crack closure

Science.gov (United States)

Telesman, Jack; Fisher, Douglas M.

1988-01-01

The location of crack closure with respect to crack wake and specimen thickness under different loading conditions was determined. The rate of increase of K sub CL in the crack wake was found to be significantly higher for plasticity induced closure in comparison to roughness induced closure. Roughness induced closure was uniform throughout the thickness of the specimen while plasticity induced closure levels were 50 percent higher in the near surface region than in the midthickness. The influence of state of stress on low-high load interaction effects was also examined. Load interaction effects differed depending upon the state of stress and were explained in terms of delta K sub eff.

Parametric peak stress functions of 90o pipe bends with ovality under steady-state creep conditions

International Nuclear Information System (INIS)

Yaghi, A.H.; Hyde, T.H.; Becker, A.A.; Sun, W.

2009-01-01

Stress-based life prediction techniques are commonly used to estimate the failure life of pressurised pipe-related components, such as welds and bends, under creep conditions. Previous research has shown that reasonable life predictions can be obtained, based on the steady-state peak stresses, compared with the life predictions obtained from creep damage modelling. In this work, a series of parametric steady-state peak rupture stress functions of right-angled pipe bends with ovality are presented, which are based on the results obtained from finite element (FE) analyses, covering a number of material property and geometry parameters in practical ranges. Methods used to determine the stress functions are described. The FE analyses have been performed using axisymmetric models, subjected to internal pressure only, with a Norton creep law. Typical examples of parametric peak stress curve fitting are shown. In particular, the accuracy of the interpolation and extrapolation abilities of the stress functions is assessed. The results show that in most cases the interpolated and extrapolated peak stresses are accurate to within ±3% and ±5%, respectively.

Diagnostic Inspection of Pipelines for Estimating the State of Stress in Them

Science.gov (United States)

Subbotin, V. A.; Kolotilov, Yu. V.; Smirnova, V. Yu.; Ivashko, S. K.

2017-12-01

The diagnostic inspection used to estimate the technical state of a pipeline is described. The problems of inspection works are listed, and a functional-structural scheme is developed to estimate the state of stress in a pipeline. Final conclusions regarding the actual loading of a pipeline section are drawn upon a cross analysis of the entire information obtained during pipeline inspection.

Geodynamics and Stress State of the Earth's Crust in the Greater and Lesser Caucasus (Azerbaijan) collision region

Science.gov (United States)

Babayev, Gulam; Akhmedova, Elnare; Babayev, Elvin

2017-04-01

The current study researches the present-day stress state of the Earth's crust within the territory of Azerbaijan by using the database of the international research project "World Stress Map" (WSM). The present stress state was also assessed by exploring the effects of the contemporary topographic properties of Caucasus in three-dimensional frame. Aiming to explore the relative roles of regional tectonic conditions in the definition of stress state of Greater and Lesser Caucasus, stress distribution model was developed by the earthquake data (1998-2016) and by the standard techniques of stress field calculation. The results show that the stress orientations are influenced also by the combination of topography and crust thickness distribution even at very large depth. Stress data and earthquake focal mechanisms indicate that the stress state of the Earth's crust of the Greater and Lesser Caucasus is characterized by the compression predominantly oriented across the regional strike. The model results suggest that the Lesser Caucasus and Kur depression are rotating coherently, with little or no internal deformation in a counter-clockwise rotation located near the north-eastern corner of the Black Sea. Orientation of stress axes well consistent with earthquake focal mechanisms revealed that within Upper and Lower Crusts, earthquakes are predominantly thrust-faulting with a number of normal-faulting and some strike-slip faulting. The map of the focal mechanisms and stress distribution suggests that the research area is characterized by the thrust of horizontal compression trending north-north-east in the western part of the southern Caucasus. In the western part of Azerbaijan, the compression takes place between the Main Caucasus Fault and the Kur depression, which strikes south along the northern margin of the mountain range. In addition, a clear transition from the left-lateral strike slip to the predominantly right-lateral strike slip is observed in the southern of

Mononuclear nonheme iron(III) complexes that show superoxide dismutase-like activity and antioxidant effects against menadione-mediated oxidative stress.

Science.gov (United States)

Hitomi, Yutaka; Iwamoto, Yuji; Kashida, Akihiro; Kodera, Masahito

2015-05-21

This communication describes the superoxide dismutase (SOD)-like activity of mononuclear iron(III) complexes with pentadentate monocarboxylamido ligands. The SOD activity can be controlled by the electronic nature of the substituent group on the ligand. The nitro-substituted complex showed clear cytoprotective activity against menadione-mediated oxidative stress in cultured cells.

Managing complex workplace stress in health care organizations: leaders' perceived legitimacy conflicts.

Science.gov (United States)

Dellve, Lotta; Wikström, Ewa

2009-12-01

To conceptualize how health care leaders' strategies to increase their influence in their psychosocial work environment are experienced and handled, and may be supported. The complex nature of the psychosocial work environment with increased stress creates significant challenges for leaders in today's health care organizations. Interviews with health care leaders (n = 39) were analysed in accordance with constructivist grounded theory. Compound identities, loyalty commitments and professional interests shape conditions for leaders' influence. Strategies to achieve legitimacy were either to retain clinical skills and a strong occupational identity or to take a full leadership role. Ethical stress was experienced when organizational procedural or consequential legitimacy norms were in conflict with the leaders' own values. Leadership support through socializing processes and strategic support structures may be complementary or counteractive. Support programmes need to have a clear message related to decision-making processes and should facilitate communication between top management, human resource departments and subordinate leaders. Ethical stress from conflicting legitimacy principles may be moderated by clear policies for decision-making processes, strengthened sound networks and improved communication. Supportive programmes should include: (1) sequential and strategic systems for introducing new leaders and mentoring; (2) reflective dialogue and feedback; (3) team development; and (4) decision-making policies and processes.

Evolution of regional stress state based on faulting and folding near the pit river, Shasta county, California

Science.gov (United States)

Austin, Lauren Jean

We investigate the evolution of the regional stress state near the Pit River, northern California, in order to understand the faulting style in a tectonic transition zone and to inform the hazard analysis of Fault 3432 near the Pit 3 Dam. By analyzing faults and folds preserved in and adjacent to a diatomite mine north of the Pit River, we have determined principal stress directions preserved during the past million years. We find that the stress state has evolved from predominantly normal to strike slip and most recently to reverse, which is consistent with regional structures such as the extensional Hat Creek Fault to the south and the compressional folding of Mushroom Rock to the north. South of the Pit River, we still observe normal and strike slip faults, suggesting that changes in stress state are moving from north to south through time.

The influence of stress state on the reorientation of hydrides in a zirconium alloy

International Nuclear Information System (INIS)

Cinbiz, Mahmut N.; Koss, Donald A.; Motta, Arthur T.

2016-01-01

Hydride reorientation can occur in spent nuclear fuel cladding when subjected to a tensile hoop stress above a threshold value during cooling. Because in these circumstances the cladding is under a multiaxial stress state, the effect of stress biaxiality on the threshold stress for hydride reorientation is investigated using hydrided CWSR Zircaloy-4 sheet specimens containing ∼180 wt ppm of hydrogen and subjected to a two-cycle thermo-mechanical treatment. The study is based on especially designed specimens within which the stress biaxiality ratios range from uniaxial (σ_2/σ_1 = 0) to “near-equibiaxial” tension (σ_2/σ_1 = 0.8). The threshold stress is determined by mapping finite element calculations of the principal stresses and of the stress biaxiality ratio onto the hydride microstructure obtained after the thermo-mechanical treatment. The results show that the threshold stress (maximum principal stress) decreases from 155 to 75 MPa as the stress biaxiality increases from uniaxial to “near-equibiaxial” tension.

Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes.

Science.gov (United States)

Sela, Dotan; Chen, Lu; Martin-Brown, Skylar; Washburn, Michael P; Florens, Laurence; Conaway, Joan Weliky; Conaway, Ronald C

2012-06-29

The basic leucine zipper transcription factor ATF6α functions as a master regulator of endoplasmic reticulum (ER) stress response genes. Previous studies have established that, in response to ER stress, ATF6α translocates to the nucleus and activates transcription of ER stress response genes upon binding sequence specifically to ER stress response enhancer elements in their promoters. In this study, we investigate the biochemical mechanism by which ATF6α activates transcription. By exploiting a combination of biochemical and multidimensional protein identification technology-based mass spectrometry approaches, we have obtained evidence that ATF6α functions at least in part by recruiting to the ER stress response enhancer elements of ER stress response genes a collection of RNA polymerase II coregulatory complexes, including the Mediator and multiple histone acetyltransferase complexes, among which are the Spt-Ada-Gcn5 acetyltransferase (SAGA) and Ada-Two-A-containing (ATAC) complexes. Our findings shed new light on the mechanism of action of ATF6α, and they outline a straightforward strategy for applying multidimensional protein identification technology mass spectrometry to determine which RNA polymerase II transcription factors and coregulators are recruited to promoters and other regulatory elements to control transcription.

Evaluation of the state of stress at the Forsmark site. Preliminary site investigation Forsmark area - version 1.2

Energy Technology Data Exchange (ETDEWEB)

Sjoeberg, Jonny; Lindfors, Ulf; Perman, Fredrik; Ask, Daniel [SwedPower AB, Stockholm (Sweden)

2005-09-15

This report presents an evaluation of the state of stress at the Forsmark site, based on all conducted stress measurements to date at the site, indirect stress estimates, geological and tectonic description of the site, and regional stress data from nearby locations. The work included (i) compilation of measurement results from Forsmark, as well as from nearby (regional) sites/locations, (ii) analysis of confidence intervals for each group of measurement, (iii) assessment of the stress state for the Forsmark site accounting for geological/tectonic evolution at the site, (iv) assessment of stress state for selected nearby (regional) sites/locations, and (v) comparison and combined interpretation of similarities and/or differences in stress state from a regional perspective. The combined assessment of the local (site-scale) and regional stress data for Forsmark showed that the major stress is orientated sub-horizontally and trending NW-SE; however, with significant local variation. A thrust faulting ({sigma}H > {sigma}h > {sigma}v) or possibly strike-slip faulting ({sigma}H > {sigma}v > {sigma}h) stress regime is evident at the Forsmark site. The maximum horizontal stress tends to be higher at the site compared to nearby sites and regional conditions. The site and regional data indicate that the vertical stress seems to be solely due to the overburden pressure. The lack of solid core discing for large portions of the boreholes at Forsmark was used to estimate an upper limit of the maximum horizontal stress magnitude. However, such an estimation is highly uncertain due to e.g. partly unknown mechanism for core discing failure, and unknown effects of the simplifying assumptions made in the analysis. The possible effects of shallow-dipping deformation zones on the stress state, could not be verified from the currently available data. However, the possibility of different stress regimes above and below deformation zones must be considered in future work. Slightly lower

Evaluation of the state of stress at the Forsmark site. Preliminary site investigation Forsmark area - version 1.2

International Nuclear Information System (INIS)

Sjoeberg, Jonny; Lindfors, Ulf; Perman, Fredrik; Ask, Daniel

2005-09-01

This report presents an evaluation of the state of stress at the Forsmark site, based on all conducted stress measurements to date at the site, indirect stress estimates, geological and tectonic description of the site, and regional stress data from nearby locations. The work included (i) compilation of measurement results from Forsmark, as well as from nearby (regional) sites/locations, (ii) analysis of confidence intervals for each group of measurement, (iii) assessment of the stress state for the Forsmark site accounting for geological/tectonic evolution at the site, (iv) assessment of stress state for selected nearby (regional) sites/locations, and (v) comparison and combined interpretation of similarities and/or differences in stress state from a regional perspective. The combined assessment of the local (site-scale) and regional stress data for Forsmark showed that the major stress is orientated sub-horizontally and trending NW-SE; however, with significant local variation. A thrust faulting (σH > σh > σv) or possibly strike-slip faulting (σH > σv > σh) stress regime is evident at the Forsmark site. The maximum horizontal stress tends to be higher at the site compared to nearby sites and regional conditions. The site and regional data indicate that the vertical stress seems to be solely due to the overburden pressure. The lack of solid core discing for large portions of the boreholes at Forsmark was used to estimate an upper limit of the maximum horizontal stress magnitude. However, such an estimation is highly uncertain due to e.g. partly unknown mechanism for core discing failure, and unknown effects of the simplifying assumptions made in the analysis. The possible effects of shallow-dipping deformation zones on the stress state, could not be verified from the currently available data. However, the possibility of different stress regimes above and below deformation zones must be considered in future work. Slightly lower horizontal stress was found in

Modelling of the in situ stress state at Olkiluoto Site, Western Finland

International Nuclear Information System (INIS)

Valli, J.; Kuula, H.; Hakala, M.

2011-06-01

In order to determine the interaction of in situ stress and geological features at Olkiluoto with the ONKALO area under more specific focus, stress modelling work was launched in 2009. This entailed updating a previously used model geometry to suit current needs whilst also updating interpreted brittle deformation zones according to the data provided by Posiva in the beginning of 2010. The previous model geometry was originally used for seismic and glacial load simulations. Brittle deformation zones were updated in the model according to a new selection criterion which added a number of brittle deformation zones. Changes in the geometry of certain brittle deformation zones were also necessary to better fit the early 2010 interpretations from Posiva. Modelling goals were to clarify the effect of joint parameters on stress magnitude and orientation and which of the major brittle deformation zones detected in the ONKALO region could have potential effects on local in situ stress states. Additional goals included modelling the effect of several optional thrust boundary conditions and an ice-age. Compression from the northwest-southeast was used as the default approach whilst north-south, east-west and northeast-southwest were optional conditions. A simplified glaciation cycle was also simulated. Results were clear in demonstrating the critical effect of joint cohesion and joint friction angle, i.e. shear strength, on stress-geology interaction, essentially in this order of importance. The case that utilised both drillhole core-logging and ONKALO tunnel mapping results did not exhibit much if any stress-geology interactions as BFZ strength parameters were too high in order to allow any interactions to occur. The geometry and orientation of brittle deformation zones was found to be of significant importance; deformation zones with a shallow dip roughly in the direction of applied compression were optimal for causing stress rotations and the increase of stress magnitude

Application of Bipartite Entangled States to Quantum Mechanical Version of Complex Wavelet Transforms

International Nuclear Information System (INIS)

Fan Hongyi; Lu Hailiang; Xu Xuefen

2006-01-01

We introduce the bipartite entangled states to present a quantum mechanical version of complex wavelet transform. Using the technique of integral within an ordered product of operators we show that the complex wavelet transform can be studied in terms of various quantum state vectors in two-mode Fock space. In this way the creterion for mother wavelet can be examined quantum-mechanically and therefore more deeply.

A complex guided spectral transform Lanczos method for studying quantum resonance states

International Nuclear Information System (INIS)

Yu, Hua-Gen

2014-01-01

A complex guided spectral transform Lanczos (cGSTL) algorithm is proposed to compute both bound and resonance states including energies, widths and wavefunctions. The algorithm comprises of two layers of complex-symmetric Lanczos iterations. A short inner layer iteration produces a set of complex formally orthogonal Lanczos (cFOL) polynomials. They are used to span the guided spectral transform function determined by a retarded Green operator. An outer layer iteration is then carried out with the transform function to compute the eigen-pairs of the system. The guided spectral transform function is designed to have the same wavefunctions as the eigenstates of the original Hamiltonian in the spectral range of interest. Therefore the energies and/or widths of bound or resonance states can be easily computed with their wavefunctions or by using a root-searching method from the guided spectral transform surface. The new cGSTL algorithm is applied to bound and resonance states of HO, and compared to previous calculations

Age, Stress, and Emotional Complexity: Results from Two Studies of Daily Experiences

Science.gov (United States)

Scott, Stacey B.; Sliwinski, Martin J.; Mogle, Jacqueline A.; Almeida, David M.

2014-01-01

Experiencing positive and negative emotions together (i.e., co-occurrence) has been described as a marker of positive adaptation during stress and a strength of socio-emotional aging. Using data from daily diary (N=2,022; ages 33-84) and ecological momentary assessment (N=190; ages 20-80) studies, we evaluate the utility of a common operationalization of co-occurrence, the within-person correlation between positive affect (PA) and negative affect (NA). Then we test competing predictions regarding when co-occurrence will be observed and whether age differences will be present. Results indicate that the correlation is not an informative indicator of co-occurrence. Although correlations were stronger and more negative when stressors occurred (typically interpreted as lower co-occurrence), objective counts of emotion reports indicated that positive and negative emotions were more 3 to 4 times likely to co-occur when stressors were reported. This suggests that co-occurrence reflects the extent to which negative emotions intrude on typically positive emotional states, rather than the extent to which people maintain positive emotions during stress. The variances of both PA and NA increased at stressor reports, indicating that individuals reported a broader not narrower range of emotion during stress. Finally, older age was associated with less variability in NA and a lower likelihood of co-occurring positive and negative emotions. In sum, these findings cast doubt on the utility of the PA-NA correlation as an index of emotional co-occurrence, and question notion that greater emotional cooccurrence represents either a typical or adaptive emotional state in adults. PMID:25244477

Sectoral contributions to surface water stress in the coterminous United States

International Nuclear Information System (INIS)

Averyt, K; Meldrum, J; Caldwell, P; Sun, G; McNulty, S; Huber-Lee, A; Madden, N

2013-01-01

Here, we assess current stress in the freshwater system based on the best available data in order to understand possible risks and vulnerabilities to regional water resources and the sectors dependent on freshwater. We present watershed-scale measures of surface water supply stress for the coterminous United States (US) using the water supply stress index (WaSSI) model which considers regional trends in both water supply and demand. A snapshot of contemporary annual water demand is compared against different water supply regimes, including current average supplies, current extreme-year supplies, and projected future average surface water flows under a changing climate. In addition, we investigate the contributions of different water demand sectors to current water stress. On average, water supplies are stressed, meaning that demands for water outstrip natural supplies in over 9% of the 2103 watersheds examined. These watersheds rely on reservoir storage, conveyance systems, and groundwater to meet current water demands. Overall, agriculture is the major demand-side driver of water stress in the US, whereas municipal stress is isolated to southern California. Water stress introduced by cooling water demands for power plants is punctuated across the US, indicating that a single power plant has the potential to stress water supplies at the watershed scale. On the supply side, watersheds in the western US are particularly sensitive to low flow events and projected long-term shifts in flow driven by climate change. The WaSSI results imply that not only are water resources in the southwest in particular at risk, but that there are also potential vulnerabilities to specific sectors, even in the ‘water-rich’ southeast. (letter)

How the nucleus and mitochondria communicate in energy production during stress: nuclear MtATP6, an early-stress responsive gene, regulates the mitochondrial F₁F₀-ATP synthase complex.

Science.gov (United States)

Moghadam, Ali Asghar; Ebrahimie, Eemaeil; Taghavi, Seyed Mohsen; Niazi, Ali; Babgohari, Mahbobeh Zamani; Deihimi, Tahereh; Djavaheri, Mohammad; Ramezani, Amin

2013-07-01

A small number of stress-responsive genes, such as those of the mitochondrial F1F0-ATP synthase complex, are encoded by both the nucleus and mitochondria. The regulatory mechanism of these joint products is mysterious. The expression of 6-kDa subunit (MtATP6), a relatively uncharacterized nucleus-encoded subunit of F0 part, was measured during salinity stress in salt-tolerant and salt-sensitive cultivated wheat genotypes, as well as in the wild wheat genotypes, Triticum and Aegilops using qRT-PCR. The MtATP6 expression was suddenly induced 3 h after NaCl treatment in all genotypes, indicating an early inducible stress-responsive behavior. Promoter analysis showed that the MtATP6 promoter includes cis-acting elements such as ABRE, MYC, MYB, GTLs, and W-boxes, suggesting a role for this gene in abscisic acid-mediated signaling, energy metabolism, and stress response. It seems that 6-kDa subunit, as an early response gene and nuclear regulatory factor, translocates to mitochondria and completes the F1F0-ATP synthase complex to enhance ATP production and maintain ion homeostasis under stress conditions. These communications between nucleus and mitochondria are required for inducing mitochondrial responses to stress pathways. Dual targeting of 6-kDa subunit may comprise as a mean of inter-organelle communication and save energy for the cell. Interestingly, MtATP6 showed higher and longer expression in the salt-tolerant wheat and the wild genotypes compared to the salt-sensitive genotype. Apparently, salt-sensitive genotypes have lower ATP production efficiency and weaker energy management than wild genotypes; a stress tolerance mechanism that has not been transferred to cultivated genotypes.

Modelling residual stresses in friction stir welding of Al alloys - a review of possibilities and future trends

DEFF Research Database (Denmark)

Hattel, Jesper Henri; Sonne, Mads Rostgaard; Tutum, Cem C.

2015-01-01

Residual stresses are very important in any joining process of materials since they act as pre-stresses in the loading situation of the joint, thereby affecting the final mechanical performance of the component. This is also the case for friction stir welding (FSW) which is a complex solid-state ......, numerical framework and application as well as putting them into proper context with respect to some of the new trends in the field, e.g. coupling with subsequent load analyses of the in-service situation or applying residual stress models of FSWin numerical optimization.......Residual stresses are very important in any joining process of materials since they act as pre-stresses in the loading situation of the joint, thereby affecting the final mechanical performance of the component. This is also the case for friction stir welding (FSW) which is a complex solid......-state joining process characterized by a pronounced multiphysical behaviour involving phenomena such as change of temperature, material flow, change of microstructures and formation of residual stresses. Thus, models of FSWare typically divided into thermal models, flow models, residual stress models...

Water stress and social vulnerability in the southern United States, 2010-2040

Science.gov (United States)

cassandra Johnson-Gaither; John Schelhas; Wayne Zipperer; Ge Sun; Peter V. Caldwell; Neelam Poudyal

2014-01-01

Water scarcities are striking in semiarid, subregions of the Southern United States such as Oklahoma and western Texas (Glennon 2009, Sabo et al. 2010). In Texas, water stress has been a constant concern since the 1950s when the state experienced severe drought conditions (Moore 2005). The nearly 2000-mile Rio Grande River, which forms part of the Texas–Mexico border,...

The contribution of trait negative affect and stress to recall for bodily states.

Science.gov (United States)

Ma-Kellams, Christine; Lai, Lei; Taylor, Shelley E; Lerner, Jennifer S

2016-12-01

How does trait negative affect shape somatic memory of stressful events? We hypothesized that negative affect would impair accurate recall of one's own heart rate during stressful situations. Two bio-behavioral studies used a new paradigm to test retrospective visceral perception and assessed whether negative affective states experienced during aversive events (i.e., the Trier Stress Task-Time 1) would retrospectively shape recall of past heart rate (Time 2), even when accounting for actual heart rate at the time of each stressful event (Time 1). Results across both studies showed that individual differences in negative affect in response to a stressful task predicted visceral recollections, and those who experienced more negative affect were more inaccurate. Negative affect was associated with a tendency to remember visceral reactions as worse than they actually were. Copyright © 2016 Elsevier Inc. All rights reserved.

Manipulating charge transfer excited state relaxation and spin crossover in iron coordination complexes with ligand substitution

DEFF Research Database (Denmark)

Zhang, Wenkai; Kjær, Kasper Skov; Alonso-Mori, Roberto

2017-01-01

iron complexes with four cyanide (CN-;) ligands and one 2,2′-bipyridine (bpy) ligand. This enables MLCT excited state and metal-centered excited state energies to be manipulated with partial independence and provides a path to suppressing spin crossover. We have combined X-ray Free-Electron Laser (XFEL...... state lifetime of iron based complexes due to spin crossover-the extremely fast intersystem crossing and internal conversion to high spin metal-centered excited states. We revitalize a 30 year old synthetic strategy for extending the MLCT excited state lifetimes of iron complexes by making mixed ligand...

State-of-stress in magmatic rift zones: Predicting the role of surface and subsurface topography

Science.gov (United States)

Oliva, S. J. C.; Ebinger, C.; Rivalta, E.; Williams, C. A.

2017-12-01

Continental rift zones are segmented along their length by large fault systems that form in response to extensional stresses. Volcanoes and crustal magma chambers cause fundamental changes to the density structure, load the plates, and alter the state-of-stress within the crust, which then dictates fracture orientation. In this study, we develop geodynamic models scaled to a structure, petrologic and thermodynamic studies constrain material densities, and seismicity and structural analyses constrain active and time-averaged kinematics. This area is an ideal test area because a 60º stress rotation is observed in time-averaged fault and magma intrusion, and in local seismicity, and because this was the site of a large volume dike intrusion and seismic sequence in 2007. We use physics-based 2D and 3D models (analytical and finite elements) constrained by data from active rift zones to quantify the effects of loading on state-of-stress. By modeling varying geometric arrangements, and density contrasts of topographic and subsurface loads, and with reasonable regional extensional forces, the resulting state-of-stress reveals the favored orientation for new intrusions. Although our models are generalized, they allow us to evaluate whether a magmatic system (surface and subsurface) can explain the observed stress rotation, and enable new intrusions, new faults, or fault reactivation with orientations oblique to the main border faults. Our results will improve our understanding of the different factors at play in these extensional regimes, as well as contribute to a better assessment of the hazards in the area.

The study on stress-strain state of the spring at high temperature using ABAQUS

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H Sun

2014-01-01

Full Text Available Cylindrical helical springs are widely used in the elements of thermal energy devices. It is necessary to guarantee the stability of the stress state of spring in high temperature. Relaxation phenomenon of stress is studied in this paper. Calculations are carried out in the environment of ABAQUS. The verification is taken out using analytical calculations.This paper describes the distribution and character of stress contour lines on the cross section of spring under the condition of instantaneous load, explicates the relaxation law with time. Research object is cylindrical helical spring, that working at high temperature. The purpose of this work is to get the stress relaxation law of spring, and to guarantee the long-term strength.This article presents the basic theory of helical spring. Establishes spring mathematical model of creep under the loads of compression and torsion. The stress formulas of each component in the cross section of spring are given. The calculation process of relaxation is analyzed in the program ABAQUS.In this paper compare the analytical formulas of spring stress with the simulation results, which are created by program ABAQUS.Finite element model for stress creep analysis in the cross section is created, material of spring – stainless steel 10X18N9T, springs are used at the temperature 650℃.At the beginning, stress-stain of spring is in the elastic state. Analyzes the change law of creep stress under the condition of constant load and a fixed compression.When analyzing under the condition of a fixed compression, the stresses are quickly decreased in most area in the cross section of spring, and the point of minimum shear stress gradually moves to the direction of outer diameter, because of this, stresses in a small area near the center increase slowly at first then decrease gradually with time. When analyzing under the condition of constant load, the stresses are quickly decreased in the around area and in creased

Finite element modelling of creep process - steady state stresses and strains

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Sedmak Aleksandar S.

2014-01-01

Full Text Available Finite element modelling of steady state creep process has been described. Using an analogy of visco-plastic problem with a described procedure, the finite element method has been used to calculate steady state stresses and strains in 2D problems. An example of application of such a procedure have been presented, using real life problem - cylindrical pipe with longitudinal crack at high temperature, under internal pressure, and estimating its residual life, based on the C*integral evaluation.

Influence of cold rolling and fatigue on the residual stress state of a metal matrix composite

International Nuclear Information System (INIS)

Hanus, E.; Ericsson, T.; Lu, J.; Decomps, F.

1993-01-01

The large difference in the coefficient of thermal expansion between the matrix alloy and the particle in a metal matrix composite gives rise to residual stresses in the material. In the present work the effect of cold rolling and four-point bending fatigue on the residual stress state of a silicon carbide particle reinforced aluminium alloy (AA 2014) has been investigated. The three dimensional stress state measured in both phases: matrix and reinforcement, has been determined by using an X-ray diffraction technique. It was found that cold rolling induces surface compressive macrostresses of about -250 MPa, with a penetration depth around 2 mm. The absolute values of the pseudomacrostresses in both phases are significantly reduced due to the single track rolling. Stress relaxation occurs during four-point bending fatigue. (orig.)

Quantifying the Physiological Stress Response to Simulated Maritime Pilotage Tasks: The Influence of Task Complexity and Pilot Experience.

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Main, Luana C; Wolkow, Alexander; Chambers, Timothy P

2017-11-01

The aim of this study was to quantify the stress associated with performing maritime pilotage tasks in a high-fidelity simulator. Eight trainee and 13 maritime pilots completed two simulated pilotage tasks of varying complexity. Salivary cortisol samples were collected pre- and post-simulation for both trials. Heart rate was measured continuously throughout the study. Significant changes in salivary cortisol (P = 0.000, η = 0.139), average (P = 0.006, η = 0.087), and peak heart rate (P = 0.013, η = 0.077) from pre- to postsimulation were found. Varying task complexity did partially influence stress response; average (P = 0.016, η = 0.026) and peak heart rate (P = 0.034, η = 0.020) were higher in the experimental condition. Trainees also recorded higher average (P = 0.000, η = 0.054) and peak heart rates (P = 0.027, η = 0.022). Performing simulated pilotage tasks evoked a measurable stress response in both trainee and expert maritime pilots.

Evidence of major genes affecting stress response in rainbow trout using Bayesian methods of complex segregation analysis

DEFF Research Database (Denmark)

Vallejo, R L; Rexroad III, C E; Silverstein, J T

2009-01-01

As a first step toward the genetic mapping of QTL affecting stress response variation in rainbow trout, we performed complex segregation analyses (CSA) fitting mixed inheritance models of plasma cortisol by using Bayesian methods in large full-sib families of rainbow trout. To date, no studies have...... been conducted to determine the mode of inheritance of stress response as measured by plasma cortisol response when using a crowding stress paradigm and CSA in rainbow trout. The main objective of this study was to determine the mode of inheritance of plasma cortisol after a crowding stress....... The results from fitting mixed inheritance models with Bayesian CSA suggest that 1 or more major genes with dominant cortisol-decreasing alleles and small additive genetic effects of a large number of independent genes likely underlie the genetic variation of plasma cortisol in the rainbow trout families...

Photosynthetic complex LH2 – Absorption and steady state fluorescence spectra

International Nuclear Information System (INIS)

Zapletal, David; Heřman, Pavel

2014-01-01

Nowadays, much effort is devoted to the study of photosynthesis which could be the basis for an ideal energy source in the future. To be able to create such an energy source – an artificial photosynthetic complex, the first step is a detailed understanding of the function of photosynthetic complexes in living organisms. Photosynthesis starts with the absorption of a solar photon by one of the LH (light-harvesting) pigment–protein complexes and transferring the excitation energy to the reaction center where a charge separation is initiated. The geometric structure of some LH complexes is known in great detail, e.g. for the LH2 complexes of purple bacteria. For understanding of photosynthesis first stage efficiency, it is necessary to study especially optical properties of LH complexes. In this paper we present simulated absorption and steady-state fluorescence spectra for ring molecular system within full Hamiltonian model. Such system can model bacteriochlorophyll ring of peripheral light-harvesting complex LH2 from purple bacterium Rhodopseudomonas acidophila (Rhodoblastus acidophilus). Dynamic disorder (coupling with phonon bath) simultaneously with uncorrelated static disorder (transfer integral fluctuations) is used in our present simulations. We compare and discuss our new results with our previously published ones and of course with experimental data. - Highlights: • We model absorption and steady state fluorescence spectra for B850 ring from LH2. • Fluctuations of environment is modelled by static and dynamic disorder. • Full Hamiltonian model is compared with the nearest neighbour approximation one. • Simulated fluorescence spectrum is compared with experimental data

Single-molecule spectroscopy reveals photosynthetic LH2 complexes switch between emissive states.

Science.gov (United States)

Schlau-Cohen, Gabriela S; Wang, Quan; Southall, June; Cogdell, Richard J; Moerner, W E

2013-07-02

Photosynthetic organisms flourish under low light intensities by converting photoenergy to chemical energy with near unity quantum efficiency and under high light intensities by safely dissipating excess photoenergy and deleterious photoproducts. The molecular mechanisms balancing these two functions remain incompletely described. One critical barrier to characterizing the mechanisms responsible for these processes is that they occur within proteins whose excited-state properties vary drastically among individual proteins and even within a single protein over time. In ensemble measurements, these excited-state properties appear only as the average value. To overcome this averaging, we investigate the purple bacterial antenna protein light harvesting complex 2 (LH2) from Rhodopseudomonas acidophila at the single-protein level. We use a room-temperature, single-molecule technique, the anti-Brownian electrokinetic trap, to study LH2 in a solution-phase (nonperturbative) environment. By performing simultaneous measurements of fluorescence intensity, lifetime, and spectra of single LH2 complexes, we identify three distinct states and observe transitions occurring among them on a timescale of seconds. Our results reveal that LH2 complexes undergo photoactivated switching to a quenched state, likely by a conformational change, and thermally revert to the ground state. This is a previously unobserved, reversible quenching pathway, and is one mechanism through which photosynthetic organisms can adapt to changes in light intensities.

FUNCTION OF MALATDEHYDROGENASE COMPLEX OF MAIZE MESOPHYLL AND BUNDLE SHEATH CELLS UNDER SALT STRESS CONDITION

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Еprintsev А.Т.

2006-12-01

Full Text Available Salt-induced changes in malatdehydrogenase system activity make the essential contribution to cell adaptation to stress condition. The enzyme systems of C4-plants are most interesting due to their ability for adaptation to environment conditions. The role of separate components of malatdehydrogenase complex of mesophyll and bundle sheath cells of corn in formation of adaptive reaction in stressful conditions is investigated in presented work.The activation of all enzymes of malatdehydrogenase system and the subsequent decrease in their activity was observed in mesophyll durring the first stage of adaptation to salt influence. In bundle sheath cells such parameters are differed from control less essentially. Fast accumulation of piruvate in cells and malate in both investigated tissues was induced. The further salinity led to falling of concentration this intermediate. The concentration of piruvate was below control level, and it was raised by the end of an exposition.The results show that sodium chloride causes induction of Krebs-cycle in mesophyll and bundle sheath cells of corn and intensification of Hatch-Slack cycle. The described differences in function malatdehydrogenase systems of mesophyll and bundle sheath cells of leaves of corn under salinity mainly consist of the activity of enzymes of a studied complex in bundle sheath cells is subject to the minimal changes in comparison with mesophyll. Role of this enzymesystem in mechanisms of adaptive reaction of various tissues of corn to salt stress is discussed.

Interface states in stressed semiconductor heterojunction with antiferromagnetic ordering

International Nuclear Information System (INIS)

Kantser, V.G.

1995-08-01

The stressed heterojunctions with antiferromagnetic ordering in which the constituents have opposite band edge symmetry and their gaps have opposite signs have been investigated. The interface states have been shown to appear in these heterojunctions and they are spin-split. As a result if the Fermi level gets into one of the interface bands then it leads to magnetic ordering in the interface plane. That is if the interface magnetization effect can be observed. (author). 14 refs, 2 figs

Family Environments and Children's Executive Function: The Mediating Role of Children's Affective State and Stress.

Science.gov (United States)

He, Zhong-Hua; Yin, Wen-Gang

2016-09-01

There is increasing evidence that inadequate family environments (family material environment and family psychosocial environment) are not only social problems but also factors contributing to adverse neurocognitive outcomes. In the present study, the authors investigated the relationship among family environments, children's naturalistic affective state, self-reported stress, and executive functions in a sample of 157 Chinese families. These findings revealed that in inadequate family material environments, reduced children's cognitive flexibility is associated with increased naturalistic negative affectivity and self-reported stress. In addition, naturalistic negative affectivity mediated the association between family expressiveness and children's cognitive flexibility. The authors used a structural equation model to examine the mediation model hypothesis, and the results confirmed the mediating roles of naturalistic negative affectivity and self-reported stress between family environments and the cognitive flexibility of Chinese children. These findings indicate the importance of reducing stress and negative emotional state for improving cognitive functions in children of low socioeconomic status.

Structural modelling and molecular dynamics of a multi-stress responsive WRKY TF-DNA complex towards elucidating its role in stress signalling mechanisms in chickpea.

Science.gov (United States)

Konda, Aravind Kumar; Farmer, Rohit; Soren, Khela Ram; P S, Shanmugavadivel; Setti, Aravind

2017-07-28

Chickpea is a premier food legume crop with high nutritional quality and attains prime importance in the current era of 795 million people being undernourished worldwide. Chickpea production encounters setbacks due to various stresses and understanding the role of key transcription factors (TFs) involved in multiple stresses becomes inevitable. We have recently identified a multi-stress responsive WRKY TF in chickpea. The present study was conducted to predict the structure of WRKY TF to identify the DNA-interacting residues and decipher DNA-protein interactions. Comparative modelling approach produced 3D model of the WRKY TF with good stereochemistry, local/global quality and further revealed W19, R20, K21, and Y22 motifs within a vicinity of 5 Å to the DNA amongst R18, G23, Q24, K25, Y36, Y37, R38 and K47 and these positions were equivalent to the 2LEX WRKY domain of Arabidopsis. Molecular simulations analysis of reference protein -PDB ID 2LEX, along with Car-WRKY TF modelled structure with the DNA coordinates derived from PDB ID 2LEX and docked using HADDOCK were executed. Root Mean Square (RMS) Deviation and RMS Fluctuation values yielded consistently stable trajectories over 50 ns simulation. Strengthening the obtained results, neither radius of gyration, distance and total energy showed any signs of DNA-WRKY complex falling apart nor any significant dissociation event over 50 ns run. Therefore, the study provides first insights into the structural properties of multi-stress responsive WRKY TF-DNA complex in chickpea, enabling genome wide identification of TF binding sites and thereby deciphers their gene regulatory networks.

Macroscopic description of complex adaptive networks coevolving with dynamic node states

Science.gov (United States)

Wiedermann, Marc; Donges, Jonathan F.; Heitzig, Jobst; Lucht, Wolfgang; Kurths, Jürgen

2015-05-01

In many real-world complex systems, the time evolution of the network's structure and the dynamic state of its nodes are closely entangled. Here we study opinion formation and imitation on an adaptive complex network which is dependent on the individual dynamic state of each node and vice versa to model the coevolution of renewable resources with the dynamics of harvesting agents on a social network. The adaptive voter model is coupled to a set of identical logistic growth models and we mainly find that, in such systems, the rate of interactions between nodes as well as the adaptive rewiring probability are crucial parameters for controlling the sustainability of the system's equilibrium state. We derive a macroscopic description of the system in terms of ordinary differential equations which provides a general framework to model and quantify the influence of single node dynamics on the macroscopic state of the network. The thus obtained framework is applicable to many fields of study, such as epidemic spreading, opinion formation, or socioecological modeling.

Unstable states produced in collisions among complex nuclei

International Nuclear Information System (INIS)

Sepulveda J, D.

1978-01-01

A theory about resonant elastic dispersion is formulated and the wave function of unstable states associated with the resonances observed in the differential and total sections is studied. The object of this theory is to extend to the elastic collisions among complex nuclei interesting case, the methods and formalism of the dispersion of particles without structure by an external potential, following an idea originally formulated by H. Feshbach. (author)

Complex interplay between health and successful aging: role of perceived stress, resilience, and social support.

Science.gov (United States)

Moore, Raeanne C; Eyler, Lisa T; Mausbach, Brent T; Zlatar, Zvinka Z; Thompson, Wesley K; Peavy, Guerry; Fazeli, Pariya L; Jeste, Dilip V

2015-06-01

Psychological and psychosocial resources, including resilience and social support, have traditionally been studied in the context of the stress paradigm and, more recently, in the context of successful aging. This study used moderated mediation analyses to examine the role of perceived stress in the relationships between physical and mental health functioning and self-rated successful aging (SRSA) and whether differences between people in level of resilience and social support changes the role of perceived stress in these relationships. A cross-sectional study of 1,006 older adults (mean age: 77 years) completed scales addressing SRSA, physical and mental health functioning, perceived stress, resilience, and social support. Results indicated that the strength of relationships between both physical and mental health functioning and SRSA were reduced after accounting for variation in level of perceived stress. The role of perceived stress in the association between mental health functioning and SRSA was found to be stronger among participants with the highest levels of resilience, and the influence of perceived stress on the degree of relationship between physical health functioning and SRSA was stronger among those with greatest social support. These findings suggest that interventions to reduce perceived stress may help break the link between disability and poor well-being in older adults. The findings further suggest that the impact of such interventions might differ depending on psychological resources (i.e., resilience) for mental health disabilities and external resources (i.e., social support) for those with physical health problems. The complex interplay of these factors should be taken into account in clinical settings. Copyright © 2015 American Association for Geriatric Psychiatry. All rights reserved.

Jahn-Teller distortion in the phosphorescent excited state of three-coordinate Au(I) phosphine complexes.

Science.gov (United States)

Barakat, Khaldoon A; Cundari, Thomas R; Omary, Mohammad A

2003-11-26

DFT calculations were used to optimize the phosphorescent excited state of three-coordinate [Au(PR3)3]+ complexes. The results indicate that the complexes rearrange from their singlet ground-state trigonal planar geometry to a T-shape in the lowest triplet luminescent excited state. The optimized structure of the exciton contradicts the structure predicted based on the AuP bonding properties of the ground-state HOMO and LUMO. The rearrangement to T-shape is a Jahn-Teller distortion because an electron is taken from the degenerate e' (5dxy, 5dx2-y2) orbital upon photoexcitation of the ground-state D3h complex. The calculated UV absorption and visible emission energies are consistent with the experimental data and explain the large Stokes' shifts while such correlations are not possible in optimized models that constrained the exciton to the ground-state trigonal geometry.

Mitochondrial Stress Signaling Promotes Cellular Adaptations

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Jayne Alexandra Barbour

2014-01-01

Full Text Available Mitochondrial dysfunction has been implicated in the aetiology of many complex diseases, as well as the ageing process. Much of the research on mitochondrial dysfunction has focused on how mitochondrial damage may potentiate pathological phenotypes. The purpose of this review is to draw attention to the less well-studied mechanisms by which the cell adapts to mitochondrial perturbations. This involves communication of stress to the cell and successful induction of quality control responses, which include mitophagy, unfolded protein response, upregulation of antioxidant and DNA repair enzymes, morphological changes, and if all else fails apoptosis. The mitochondrion is an inherently stressful environment and we speculate that dysregulation of stress signaling or an inability to switch on these adaptations during times of mitochondrial stress may underpin mitochondrial dysfunction and hence amount to pathological states over time.

Age, stress, and emotional complexity: results from two studies of daily experiences.

Science.gov (United States)

Scott, Stacey B; Sliwinski, Martin J; Mogle, Jacqueline A; Almeida, David M

2014-09-01

Experiencing positive and negative emotions together (i.e., co-occurrence) has been described as a marker of positive adaptation during stress and a strength of socioemotional aging. Using data from daily diary (N = 2,022; ages 33-84) and ecological momentary assessment (N = 190; ages 20-80) studies, we evaluate the utility of a common operationalization of co-occurrence, the within-person correlation between positive affect (PA) and negative affect (NA). Then we test competing predictions regarding when co-occurrence will be observed and whether age differences will be present. Results indicate that the correlation is not an informative indicator of co-occurrence. Although correlations were stronger and more negative when stressors occurred (typically interpreted as lower co-occurrence), objective counts of emotion reports indicated that positive and negative emotions were 3 to 4 times more likely to co-occur when stressors were reported. This suggests that co-occurrence reflects the extent to which negative emotions intrude on typically positive emotional states, rather than the extent to which people maintain positive emotions during stress. The variances of both PA and NA increased at stressor reports, indicating that individuals reported a broader not narrower range of emotion during stress. Finally, older age was associated with less variability in NA and a lower likelihood of co-occurring positive and negative emotions. In sum, these findings cast doubt on the utility of the PA-NA correlation as an index of emotional co-occurrence, and question notion that greater emotional co-occurrence represents either a typical or adaptive emotional state in adults. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Thermal stresses in an orthotropic rectangular plate with a rigid ribbonlike inclusion

International Nuclear Information System (INIS)

Sumi, N.

1981-01-01

On the basis of the complex variable method for determining the stationary two-dimensional thermal stresses, the thermal stresses in an orthotropic rectangular plate with a rigid ribbonlike inclusion under a steady state temperature field is considered. The solution is found by the analytic continuation argument and the modified mapping-collocation technique. Numerical results indicate a dependence of the orthotropic stress intensity factors on the thermal, elastic and geometrical constants over a certain parameter range. (orig.)

Investigations into the Surface Strain/Stress State in a Single-Crystal Superalloy via XRD Characterization

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Haodong Duan

2018-05-01

Full Text Available The present study was aimed at determining the surface strain/stress state in an Ni-based single-crystal (SC superalloy that was subjected to two different cooling rates from solid solution temperature through using the X-ray diffraction (XRD method. The normal stresses σ 11 s and σ 22 s were determined, then the Von Mises stresses ( σ V M s were derived from them. Field emission gun scanning electron microscope (FEG-SEM and transmission electron microscope (TEM micrographs were taken to illustrate the strain/stress state change. The precipitation of the secondary γ′ phases in the γ phase and the formation of the dislocation in the interphase upon a slower cooling rate caused the γ phase lattice distortion to increase, so a larger σ V M s of the γ phase was realized in comparison to the faster cooling sample. For both of the two cooling modes, we found that the σ V M s of the γ′ phase increased due to the growth of the γ′ phase during the aging process. Also, the aging process led to pronouncedly anisotropic lattice mismatches in the {331} and {004} planes. In addition, the surface strain/stress states of a cylinder sample and a tetragonal sample were also studied using a faster cooling rate, and σ 11 s and σ 22 s were analyzed to explain the influence of the shape factor on the stress anisotropy in the [001] and [ 1 1 ¯ 0 ] orientations. The strain in the [001] orientation of the γ phase is more sensitive to the shape change.

Reconfiguration of Brain Network Architectures between Resting-State and Complexity-Dependent Cognitive Reasoning.

Science.gov (United States)

Hearne, Luke J; Cocchi, Luca; Zalesky, Andrew; Mattingley, Jason B

2017-08-30

Our capacity for higher cognitive reasoning has a measurable limit. This limit is thought to arise from the brain's capacity to flexibly reconfigure interactions between spatially distributed networks. Recent work, however, has suggested that reconfigurations of task-related networks are modest when compared with intrinsic "resting-state" network architecture. Here we combined resting-state and task-driven functional magnetic resonance imaging to examine how flexible, task-specific reconfigurations associated with increasing reasoning demands are integrated within a stable intrinsic brain topology. Human participants (21 males and 28 females) underwent an initial resting-state scan, followed by a cognitive reasoning task involving different levels of complexity, followed by a second resting-state scan. The reasoning task required participants to deduce the identity of a missing element in a 4 × 4 matrix, and item difficulty was scaled parametrically as determined by relational complexity theory. Analyses revealed that external task engagement was characterized by a significant change in functional brain modules. Specifically, resting-state and null-task demand conditions were associated with more segregated brain-network topology, whereas increases in reasoning complexity resulted in merging of resting-state modules. Further increments in task complexity did not change the established modular architecture, but affected selective patterns of connectivity between frontoparietal, subcortical, cingulo-opercular, and default-mode networks. Larger increases in network efficiency within the newly established task modules were associated with higher reasoning accuracy. Our results shed light on the network architectures that underlie external task engagement, and highlight selective changes in brain connectivity supporting increases in task complexity. SIGNIFICANCE STATEMENT Humans have clear limits in their ability to solve complex reasoning problems. It is thought that

Numerical analysis of interacting cracks in biaxial stress field

International Nuclear Information System (INIS)

Kovac, M.; Cizelj, L.

1999-01-01

The stress corrosion cracks as seen for example in PWR steam generator tubing made of Inconel 600 usually produce highly irregular kinked and branched crack patterns. Crack initialization and propagation depends on stress state underlying the crack pattern. Numerical analysis (such as finite element method) of interacting kinked and branched cracks can provide accurate solutions. This paper discusses the use of general-purpose finite element code ABAQUS for evaluating stress fields at crack tips of interacting complex cracks. The results obtained showed reasonable agreement with the reference solutions and confirmed use of finite elements in such class of problems.(author)

Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts.

Science.gov (United States)

Adamczyk, Jagoda; Deregowska, Anna; Skoneczny, Marek; Skoneczna, Adrianna; Natkanska, Urszula; Kwiatkowska, Aleksandra; Rawska, Ewa; Potocki, Leszek; Kuna, Ewelina; Panek, Anita; Lewinska, Anna; Wnuk, Maciej

2016-09-01

The yeast strains of the Saccharomyces sensu stricto complex involved in beer production are a heterogeneous group whose genetic and genomic features are not adequately determined. Thus, the aim of the present study was to provide a genetic characterization of selected group of commercially available brewing yeasts both ale top-fermenting and lager bottom-fermenting strains. Molecular karyotyping revealed that the diversity of chromosome patterns and four strains with the most accented genetic variabilities were selected and subjected to genome-wide array-based comparative genomic hybridization (array-CGH) analysis. The differences in the gene copy number were found in five functional gene categories: (1) maltose metabolism and transport, (2) response to toxin, (3) siderophore transport, (4) cellular aldehyde metabolic process, and (5) L-iditol 2-dehydrogenase activity (p < 0.05). In the Saflager W-34/70 strain (Fermentis) with the most affected array-CGH profile, loss of aryl-alcohol dehydrogenase (AAD) gene dosage correlated with an imbalanced redox state, oxidative DNA damage and breaks, lower levels of nucleolar proteins Nop1 and Fob1, and diminished tolerance to fermentation-associated stress stimuli compared to other strains. We suggest that compromised stress response may not only promote oxidant-based changes in the nucleolus state that may affect fermentation performance but also provide novel directions for future strain improvement.

Family Complexity and the Stress Process in Prison: How Sibling Living Arrangements of Minor Children Influence Maternal Role Strains

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Holly Foster

2017-07-01

Full Text Available This paper offers a life-course stress process perspective on maternal role strain as a ‘pain of imprisonment’ by engaging the concept of ‘family complexity’ in the context of mass incarceration I consider how the living arrangements of minor siblings (i.e., those living apart or together during maternal incarceration functions as a form of family complexity. When minor children live apart from their siblings, they may experience more isolation which may further serve as a stressor for incarcerated mothers. A positive association between siblings living apart and maternal role strain would support a process of ‘stress proliferation’ across the prison-family interface. I investigate these connections using survey-based data on mothers with multiple minor children (n = 80 collected in 2011 from a voluntary sample of respondents housed in a federal minimum security prison in the United States. Multivariate logistic regression results indicate that minor siblings living apart during periods of maternal confinement elevates role strain among mothers (odds ratio = 3.66, p < 0.05. This connection is indicative of an ‘inter-institutional strain.’ Finally, children’s age also increases maternal role strain, but this finding is explained by sibling living arrangements during the mother’s incarceration.

The association of posttraumatic stress disorder, complex posttraumatic stress disorder, and borderline personality disorder from a network analytical perspective.

Science.gov (United States)

Knefel, Matthias; Tran, Ulrich S; Lueger-Schuster, Brigitte

2016-10-01

Posttraumatic Stress Disorder (PTSD), Complex PTSD, and Borderline Personality Disorder (BPD) share etiological risk factors and an overlapping set of associated symptoms. Since the ICD-11 proposal for trauma-related disorders, the relationship of these disorders has to be clarified. A novel approach to psychopathology, network analysis, allows for a detailed analysis of comorbidity on symptom level. Symptoms were assessed in adult survivors of childhood abuse (N=219) using the newly developed ICD-11 Trauma-Questionnaire and the SCID-II. The psychopathological network was analyzed using the network approach. PTSD and Complex PTSD symptoms were strongly connected within disorders and to a lesser degree between disorders. Symptoms of BPD were weakly connected to others. Re-experiencing and dissociation were the most central symptoms. Mental disorders are no discrete entities, clear boundaries are unlikely to be found. The psychopathological network revealed central symptoms that might be important targets for specific first interventions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Stress-free states of continuum dislocation fields : Rotations, grain boundaries, and the Nye dislocation density tensor

NARCIS (Netherlands)

Limkumnerd, Surachate; Sethna, James P.

We derive general relations between grain boundaries, rotational deformations, and stress-free states for the mesoscale continuum Nye dislocation density tensor. Dislocations generally are associated with long-range stress fields. We provide the general form for dislocation density fields whose

Polyamines and abiotic stress in plants: A complex relationship

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Rakesh eMinocha

2014-05-01

Full Text Available The physiological relationship between abiotic stress in plants and polyamines was reported more than 40 years ago. Ever since there has been a debate as to whether increased polyamines protect plants against abiotic stress (e.g. due to their ability to deal with oxidative radicals or cause damage to them (perhaps due to hydrogen peroxide produced by their catabolism. The observation that cellular polyamines are typically elevated in plants under both short-term as well as long-term abiotic stress conditions is consistent with the possibility of their dual effects, i.e. being a protector as well as a perpetrator of stress damage to the cells. The observed increase in tolerance of plants to abiotic stress when their cellular contents are elevated by either exogenous treatment with polyamines or through genetic engineering with genes encoding polyamine biosynthetic enzymes is indicative of a protective role for them. However, through their catabolic production of hydrogen peroxide and acrolein, both strong oxidizers, they can potentially be the cause of cellular harm during stress. In fact, somewhat enigmatic but strong positive relationship between abiotic stress and foliar polyamines has been proposed as a potential biochemical marker of persistent environmental stress in forest trees in which phenotypic symptoms of stress are not yet visible. Such markers may help forewarn forest managers to undertake amelioration strategies before the appearance of visual symptoms of stress and damage at which stage it is often too late for implementing strategies for stress remediation and reversal of damage. This review provides a comprehensive and critical evaluation of the published literature on interactions between abiotic stress and polyamines in plants, and examines the experimental strategies used to understand the functional significance of this relationship with the aim of improving plant productivity, especially under conditions of abiotic stress.

A large-scale perspective on stress-induced alterations in resting-state networks

Science.gov (United States)

Maron-Katz, Adi; Vaisvaser, Sharon; Lin, Tamar; Hendler, Talma; Shamir, Ron

2016-02-01

Stress is known to induce large-scale neural modulations. However, its neural effect once the stressor is removed and how it relates to subjective experience are not fully understood. Here we used a statistically sound data-driven approach to investigate alterations in large-scale resting-state functional connectivity (rsFC) induced by acute social stress. We compared rsfMRI profiles of 57 healthy male subjects before and after stress induction. Using a parcellation-based univariate statistical analysis, we identified a large-scale rsFC change, involving 490 parcel-pairs. Aiming to characterize this change, we employed statistical enrichment analysis, identifying anatomic structures that were significantly interconnected by these pairs. This analysis revealed strengthening of thalamo-cortical connectivity and weakening of cross-hemispheral parieto-temporal connectivity. These alterations were further found to be associated with change in subjective stress reports. Integrating report-based information on stress sustainment 20 minutes post induction, revealed a single significant rsFC change between the right amygdala and the precuneus, which inversely correlated with the level of subjective recovery. Our study demonstrates the value of enrichment analysis for exploring large-scale network reorganization patterns, and provides new insight on stress-induced neural modulations and their relation to subjective experience.

Complex and extensive post-transcriptional regulation revealed by integrative proteomic and transcriptomic analysis of metabolite stress response in Clostridium acetobutylicum.

Science.gov (United States)

Venkataramanan, Keerthi P; Min, Lie; Hou, Shuyu; Jones, Shawn W; Ralston, Matthew T; Lee, Kelvin H; Papoutsakis, E Terry

2015-01-01

Clostridium acetobutylicum is a model organism for both clostridial biology and solvent production. The organism is exposed to its own toxic metabolites butyrate and butanol, which trigger an adaptive stress response. Integrative analysis of proteomic and RNAseq data may provide novel insights into post-transcriptional regulation. The identified iTRAQ-based quantitative stress proteome is made up of 616 proteins with a 15 % genome coverage. The differentially expressed proteome correlated poorly with the corresponding differential RNAseq transcriptome. Up to 31 % of the differentially expressed proteins under stress displayed patterns opposite to those of the transcriptome, thus suggesting significant post-transcriptional regulation. The differential proteome of the translation machinery suggests that cells employ a different subset of ribosomal proteins under stress. Several highly upregulated proteins but with low mRNA levels possessed mRNAs with long 5'UTRs and strong RBS scores, thus supporting the argument that regulatory elements on the long 5'UTRs control their translation. For example, the oxidative stress response rubrerythrin was upregulated only at the protein level up to 40-fold without significant mRNA changes. We also identified many leaderless transcripts, several displaying different transcriptional start sites, thus suggesting mRNA-trimming mechanisms under stress. Downregulation of Rho and partner proteins pointed to changes in transcriptional elongation and termination under stress. The integrative proteomic-transcriptomic analysis demonstrated complex expression patterns of a large fraction of the proteome. Such patterns could not have been detected with one or the other omic analyses. Our analysis proposes the involvement of specific molecular mechanisms of post-transcriptional regulation to explain the observed complex stress response.

Practical application of fracture mechanics with consideration of multiaxiality of stress state to degraded nuclear piping

International Nuclear Information System (INIS)

Kussmaul, K.; Blind, D.; Herter, K.H.; Eisele, U.; Schuler, X.

1995-01-01

Within the scope of a research project nuclear piping components (T-branches and elbows) with dimensions like the primary coolant lines of PWR plants were investigated. In addition to the experimental full scale tests, extensive numerical calculations by means of the finite element method (FEM) as well as fracture mechanics analyses were performed. The applicability of these methods was verified by comparison with the experimental results. The calculation of fracture mechanics parameters as well as the calculated component stress enabled a statement on crack initiation. The failure behavior could be evaluated by means of the multiaxiality of stress state in the ligament (gradient of the quotient of the multiaxiality of stress state q). With respect to practical application on other pressurized components it is shown how to use the procedure (e.g. in a LBB analysis). A quantitative assessment with regard to crack initiation is possible by comparison of the effective crack initiation value J ieff with the calculated component stress. If the multiaxiality of stress state and the q gradient in the ligament of the fracture ligament of the fracture mechanics specimen and the pressurized component to be evaluated is comparable a quantitative assessment is possible as for crack extension and maximum load. If there is no comparability of the gradients a qualitative assessment is possible for the failure behavior

Complex network analysis of state spaces for random Boolean networks

Energy Technology Data Exchange (ETDEWEB)

Shreim, Amer [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada); Berdahl, Andrew [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada); Sood, Vishal [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada); Grassberger, Peter [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada); Paczuski, Maya [Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4 (Canada)

2008-01-15

We apply complex network analysis to the state spaces of random Boolean networks (RBNs). An RBN contains N Boolean elements each with K inputs. A directed state space network (SSN) is constructed by linking each dynamical state, represented as a node, to its temporal successor. We study the heterogeneity of these SSNs at both local and global scales, as well as sample to-sample fluctuations within an ensemble of SSNs. We use in-degrees of nodes as a local topological measure, and the path diversity (Shreim A et al 2007 Phys. Rev. Lett. 98 198701) of an SSN as a global topological measure. RBNs with 2 {<=} K {<=} 5 exhibit non-trivial fluctuations at both local and global scales, while K = 2 exhibits the largest sample-to-sample (possibly non-self-averaging) fluctuations. We interpret the observed 'multi scale' fluctuations in the SSNs as indicative of the criticality and complexity of K = 2 RBNs. 'Garden of Eden' (GoE) states are nodes on an SSN that have in-degree zero. While in-degrees of non-GoE nodes for K > 1 SSNs can assume any integer value between 0 and 2{sup N}, for K = 1 all the non-GoE nodes in a given SSN have the same in-degree which is always a power of two.

Complex network analysis of state spaces for random Boolean networks

International Nuclear Information System (INIS)

Shreim, Amer; Berdahl, Andrew; Sood, Vishal; Grassberger, Peter; Paczuski, Maya

2008-01-01

We apply complex network analysis to the state spaces of random Boolean networks (RBNs). An RBN contains N Boolean elements each with K inputs. A directed state space network (SSN) is constructed by linking each dynamical state, represented as a node, to its temporal successor. We study the heterogeneity of these SSNs at both local and global scales, as well as sample to-sample fluctuations within an ensemble of SSNs. We use in-degrees of nodes as a local topological measure, and the path diversity (Shreim A et al 2007 Phys. Rev. Lett. 98 198701) of an SSN as a global topological measure. RBNs with 2 ≤ K ≤ 5 exhibit non-trivial fluctuations at both local and global scales, while K = 2 exhibits the largest sample-to-sample (possibly non-self-averaging) fluctuations. We interpret the observed 'multi scale' fluctuations in the SSNs as indicative of the criticality and complexity of K = 2 RBNs. 'Garden of Eden' (GoE) states are nodes on an SSN that have in-degree zero. While in-degrees of non-GoE nodes for K > 1 SSNs can assume any integer value between 0 and 2 N , for K = 1 all the non-GoE nodes in a given SSN have the same in-degree which is always a power of two

Assessment of Creep Deformation, Damage, and Rupture Life of 304HCu Austenitic Stainless Steel Under Multiaxial State of Stress

Science.gov (United States)

Sahoo, K. C.; Goyal, Sunil; Parameswaran, P.; Ravi, S.; Laha, K.

2018-03-01

The role of the multiaxial state of stress on creep deformation and rupture behavior of 304HCu austenitic stainless steel was assessed by performing creep rupture tests on both smooth and notched specimens of the steel. The multiaxial state of stress was introduced by incorporating circumferential U-notches of different root radii ranging from 0.25 to 5.00 mm on the smooth specimens of the steel. Creep tests were carried out at 973 K over the stress range of 140 to 220 MPa. In the presence of notch, the creep rupture strength of the steel was found to increase with the associated decrease in rupture ductility. Over the investigated stress range and notch sharpness, the strengthening was found to increase drastically with notch sharpness and tended toward saturation. The fractographic studies revealed the mixed mode of failure consisting of transgranular dimples and intergranular creep cavitation for shallow notches, whereas the failure was predominantly intergranular for relatively sharper notches. Detailed finite element analysis of stress distribution across the notch throat plane on creep exposure was carried out to assess the creep failure of the material in the presence of notch. The reduction in von-Mises stress across the notch throat plane, which was greater for sharper notches, increased the creep rupture strength of the material. The variation in fracture behavior of the material in the presence of notch was elucidated based on the von-Mises, maximum principal, and hydrostatic stresses. Electron backscatter diffraction analysis of creep strain distribution across the notch revealed localized creep straining at the notch root for sharper notches. A master curve for predicting creep rupture life under the multiaxial state of stress was generated considering the representative stress having contributions from both the von-Mises and principal stress components of the stress field in the notch throat plane. Rupture ductility was also predicted based on the

Stress-state monitoring of coal pillars during room and pillar extraction

Czech Academy of Sciences Publication Activity Database

Waclawik, Petr; Ptáček, Jiří; Koníček, Petr; Kukutsch, Radovan; Němčík, J.

2016-01-01

Roč. 15, č. 2 (2016), s. 49-56 ISSN 2300-3960 R&D Projects: GA MŠk(CZ) LO1406; GA MŠk ED2.1.00/03.0082 Institutional support: RVO:68145535 Keywords : stress-state monitoring * room and pillar * coal pillar Subject RIV: DH - Mining , incl. Coal Mining http://www.sciencedirect.com/science/article/pii/S2300396016300180

Stress state of thin – walled member of the structure with operation damages under nonuniform loading

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В.В. Астанін

2004-01-01

Full Text Available  The publication is dedicated to determining of stress state in particular the stress concentration factors for thin – walled members of the structures subject to nonuniform tension. A structure member has obtained the operation damage generation by corrosion and other causes.

Inverse relationship between the complexity of midfoot kinematics and muscle activation in patients with medial tibial stress syndrome

DEFF Research Database (Denmark)

Rathleff, M S; Samani, Afshin; Olesen, C G

2011-01-01

Medial tibial stress syndrome is a common overuse injury characterized by pain located on the medial side of the lower leg during weight bearing activities such as gait. The purpose of this study was to apply linear and nonlinear methods to compare the structure of variability of midfoot kinematics...... and surface electromyographic (SEMG) signals between patients with medial tibial stress syndrome and healthy controls during gait. Fourteen patients diagnosed with medial tibial stress syndrome and 11 healthy controls were included from an orthopaedic clinic. SEMG from tibialis anterior and the soleus muscles...... as well as midfoot kinematics were recorded during 20 consecutive gait cycles. Permuted sample entropy and permutation entropy were used as a measure of complexity from SEMG signals and kinematics. SEMG signals in patients with medial tibial stress syndrome were characterized by higher structural...

Oxidative stress markers in hypertensive states of pregnancy: preterm and term disease.

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Lesia Olha Kurlak

2014-08-01

Full Text Available Discussion continues as to whether de novo hypertension in pregnancy with significant proteinuria (pre-eclampsia; PE and non-proteinuric new hypertension (gestational hypertension; GH are parts of the same disease spectrum or represent different conditions. Non-pregnant hypertension, pregnancy and PE are all associated with oxidative stress. We have established a 6 weeks post-partum clinic for women who experienced a hypertensive pregnancy. We hypothesized that PE and GH could be distinguished by markers of oxidative stress; thiobarbituric acid reactive substances (TBARS and antioxidants (ferric ion reducing ability of plasma; FRAP. Since the severity of PE and GH is greater pre-term, we also compared pre-term and term disease. Fifty-eight women had term PE, 23 pre-term PE, 60 had term GH and 6 pre-term GH, 11 pre-existing (essential hypertension (EH without PE. Limited data were available from normotensive pregnancies (n=7 and non-pregnant controls (n=14. There were no differences in postpartum TBARS or FRAP between hypertensive states; TBARS (P=0.001 and FRAP (P=0.009 were lower in plasma of non-pregnant controls compared to recently-pregnant women. Interestingly FRAP was higher in preterm than term GH (P=0.013. In PE and GH, TBARS correlated with low density lipoprotein (LDL-cholesterol (P=0.036; this association strengthened with inclusion of EH ((P=0.011. The 10 year Framingham index for cardiovascular risk was positively associated with TBARS (P=0.003.Oxidative stress profiles do not differ between hypertensive states but appear to distinguish between recently-pregnant and non-pregnant states. This suggests that pregnancy may alter vascular integrity with changes remaining 6 weeks postpartum. LDL-cholesterol is a known determinant of oxidative stress in cardiovascular disease and we have shown this association to be present in hypertensive pregnancy further emphasizing that such a pregnancy may be revealing a pre-existing cardiovascular

Experimental study on the thermo-mechanical behaviour of stiff clay under non-isotropic stress state

International Nuclear Information System (INIS)

Tang, Anh Minh; Cui, Yu-Jun; Li, Xiang-Ling

2012-01-01

Document available in extended abstract form only. Stiff clay is usually considered as possible host-rock for geological radioactive waste disposal due to its low permeability and its self-sealing capacity. Boom Clay, for instance, is one of the clays currently considered by the Belgian radioactive waste management agency Ondraf/Niras as a potential host for a geological repository. In order to analyse the performance of this material, it is important to understand its behaviour under the coupled thermo-hydro-mechanical solicitations. In laboratory, several studies have been performed to study the volume change of clay under coupled thermomechanical loading. The results show that heating under drained conditions can induce thermal dilation at low confining stress and thermal contraction at high confining stress. On the other hand, compression tests performed at constant temperature show that the compressibility parameters of soil can be modified by temperature change. These features are now well considered in constitutive laws based on the framework of elasto-plasticity. Under undrained conditions, heating can increase pore-water pressure and this behaviour can be simulated using the theoretical thermo-poro-elastic framework. The temperature effect on the soil behaviour under triaxial compression is also often considered. It is commonly accepted that heating decreases the shear strength of clay but this softening can be hidden by the thermal contraction that occurs during heating which can induce at the same time soil hardening. In spite of these existing works, laboratory tests considering the thermo-mechanical loading path that the soil can be subjected to are still rare. Actually, in the case of geological radioactive waste disposal, after the installation of waste canisters, the soil is expected to be heated under non-isotropic stress state. Most of the existing laboratory works show heating tests in odometer cell or triaxial cell under isotropic stress

Mastering the biaxial stress state in nanometric thin films on flexible substrates

Energy Technology Data Exchange (ETDEWEB)

Faurie, D., E-mail: faurie@univ-paris13.fr [LSPM-CNRS, UPR3407, Université Paris 13, Villetaneuse (France); Renault, P.-O.; Le Bourhis, E. [Institut Pprime UPR3346, CNRS – Université de Poitiers, Futuroscope (France); Geandier, G. [Institut Jean Lamour, CNRS UMR7198, Université de Lorraine, Nancy Cedex (France); Goudeau, P. [Institut Pprime UPR3346, CNRS – Université de Poitiers, Futuroscope (France); Thiaudière, D. [SOLEIL Synchrotron, Saint-Aubin, Gif-Sur-Yvette (France)

2014-07-01

Biaxial stress state of thin films deposited on flexible substrate can be mastered thanks to a new biaxial device. This tensile machine allows applying in-plane loads F{sub x} and F{sub y} in the two principal directions x and y of a cruciform-shaped polymer substrate. The transmission of the deformation at film/substrate interface allows controlling the stress and strain field in the thin films. We show in this paper a few illustrations dealing with strain measurements in polycrystalline thin films deposited on flexible substrate. The potentialities of the biaxial device located at Soleil synchrotron are also discussed.

Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State

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Valeria Gasperi

2013-05-01

Full Text Available Obesity represents a major risk factor for a plethora of severe diseases, including diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and cancer. It is often accompanied by an increased risk of mortality and, in the case of non-fatal health problems, the quality of life is impaired because of associated conditions, including sleep apnea, respiratory problems, osteoarthritis, and infertility. Recent evidence suggests that oxidative stress may be the mechanistic link between obesity and related complications. In obese patients, antioxidant defenses are lower than normal weight counterparts and their levels inversely correlate with central adiposity; obesity is also characterized by enhanced levels of reactive oxygen or nitrogen species. Inadequacy of antioxidant defenses probably relies on different factors: obese individuals may have a lower intake of antioxidant- and phytochemical-rich foods, such as fruits, vegetables, and legumes; otherwise, consumption of antioxidant nutrients is normal, but obese individuals may have an increased utilization of these molecules, likewise to that reported in diabetic patients and smokers. Also inadequate physical activity may account for a decreased antioxidant state. In this review, we describe current concepts in the meaning of obesity as a state of chronic oxidative stress and the potential interventions to improve redox balance.

Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State

Science.gov (United States)

Savini, Isabella; Catani, Maria Valeria; Evangelista, Daniela; Gasperi, Valeria; Avigliano, Luciana

2013-01-01

Obesity represents a major risk factor for a plethora of severe diseases, including diabetes, cardiovascular disease, non-alcoholic fatty liver disease, and cancer. It is often accompanied by an increased risk of mortality and, in the case of non-fatal health problems, the quality of life is impaired because of associated conditions, including sleep apnea, respiratory problems, osteoarthritis, and infertility. Recent evidence suggests that oxidative stress may be the mechanistic link between obesity and related complications. In obese patients, antioxidant defenses are lower than normal weight counterparts and their levels inversely correlate with central adiposity; obesity is also characterized by enhanced levels of reactive oxygen or nitrogen species. Inadequacy of antioxidant defenses probably relies on different factors: obese individuals may have a lower intake of antioxidant- and phytochemical-rich foods, such as fruits, vegetables, and legumes; otherwise, consumption of antioxidant nutrients is normal, but obese individuals may have an increased utilization of these molecules, likewise to that reported in diabetic patients and smokers. Also inadequate physical activity may account for a decreased antioxidant state. In this review, we describe current concepts in the meaning of obesity as a state of chronic oxidative stress and the potential interventions to improve redox balance. PMID:23698776

Troxerutin attenuates diet-induced oxidative stress, impairment of mitochondrial biogenesis and respiratory chain complexes in mice heart.

Science.gov (United States)

Rajagopalan, Geetha; Chandrasekaran, Sathiya Priya; Carani Venkatraman, Anuradha

2017-01-01

Mitochondrial abnormality is thought to play a key role in cardiac disease originating from the metabolic syndrome (MS). We evaluated the effect of troxerutin (TX), a semi-synthetic derivative of the natural bioflavanoid rutin, on the respiratory chain complex activity, oxidative stress, mitochondrial biogenesis and dynamics in heart of high fat, high fructose diet (HFFD) -induced mouse model of MS. Adult male Mus musculus mice of body weight 25-30 g were fed either control diet or HFFD for 60 days. Mice from each dietary regimen were divided into two groups on the 16th day and were treated or untreated with TX (150 mg/kg body weight [bw], per oral) for the next 45 days. At the end of experimental period, respiratory chain complex activity, uncoupling proteins (UCP)-2 and -3, mtDNA content, mitochondrial biogenesis and dynamics, oxidative stress markers and reactive oxygen species (ROS) generation were analyzed. Reduced mtDNA abundance with alterations in the expression of genes related to mitochondrial biogenesis and fission and fusion processes were observed in HFFD-fed mice. Disorganized and smaller mitochondria, reduction in complexes I, III and IV activities (by about 55%) and protein levels of UCP-2 (52%) and UCP-3 (46%) were noted in these mice. TX administration suppressed oxidative stress, improved the oxidative capacity and biogenesis and restored fission/fusion imbalance in the cardiac mitochondria of HFFD-fed mice. TX protects the myocardium by modulating the putative molecules of mitochondrial biogenesis and dynamics and by its anti-oxidant function in a mouse model of MS. © 2016 John Wiley & Sons Australia, Ltd.

Physically elastic analysis of a cylindrical ring as a unit cell of a complete composite under applied stress in the complex plane using cubic polynomials

Science.gov (United States)

Monfared, Vahid

2018-03-01

Elastic analysis is analytically presented to predict the behaviors of the stress and displacement components in the cylindrical ring as a unit cell of a complete composite under applied stress in the complex plane using cubic polynomials. This analysis is based on the complex computation of the stress functions in the complex plane and polar coordinates. Also, suitable boundary conditions are considered and assumed to analyze along with the equilibrium equations and bi-harmonic equation. This method has some important applications in many fields of engineering such as mechanical, civil and material engineering generally. One of the applications of this research work is in composite design and designing the cylindrical devices under various loadings. Finally, it is founded that the convergence and accuracy of the results are suitable and acceptable through comparing the results.

Extracellular redox state: refining the definition of oxidative stress in aging.

Science.gov (United States)

Jones, Dean P

2006-01-01

Oxidative stress in aging can result from an imbalance of prooxidants and antioxidants with excessive, destructive free radical chemistry. Thiol systems are important in the control of these processes, both by protecting against damage and serving in redox signaling mechanisms to sense danger and repair the damage. Studies by a number of research groups in collaboration with the Emory Clinical Biomarkers Laboratory show that the redox state of the central tissue antioxidant, glutathione (GSH), can be measured in human plasma and provides a quantitative systemic indicator of oxidative stress. Plasma GSH/GSSG redox in humans becomes oxidized with age, in response to chemotherapy, as a consequence of cigarette smoking, and in association with common age-related diseases (e.g., type 2 diabetes, cardiovascular disease). However, the GSH/GSSG redox is not equilibrated with the larger plasma cysteine/cystine (Cys/CySS) pool, and the Cys/CySS redox varies with age in a pattern that is distinct from that of GSH/GSSG redox. Furthermore, in vitro studies show that variation in Cys/CySS redox over the range found in vivo affects signaling pathways, which control cell proliferation and oxidant-induced apoptosis. The results point to the conclusion that free radical scavenging antioxidants are of increased importance when thiol/disulfide redox states are oxidized. Because thiol/disulfide redox states, per se, function in redox signaling and control as well as antioxidant protection, GSH/GSSG and Cys/CySS redox states may provide central parameters to link environmental influences and progression of changes associated with aging.

Stabilizing Group Treatment for Complex Posttraumatic Stress Disorder Related to Childhood Abuse Based on Psycho-Education and Cognitive Behavioral Therapy: A Pilot Study

Science.gov (United States)

Dorrepaal, Ethy; Thomaes, Kathleen; Smit, Johannes H.; van Balkom, Anton J. L. M.; van Dyck, Richard; Veltman, Dick J.; Draijer, Nel

2010-01-01

Objective: This study tests a Stabilizing Group Treatment protocol, designed for the management of the long-term sequelae of child abuse, that is, Complex Posttraumatic Stress Disorder (Complex PTSD). Evidence-based treatment for this subgroup of PTSD patients is largely lacking. This stabilizing treatment aims at improving Complex PTSD using…

Occupational Stress and Management Strategies of Secondary School Principals in Cross River State, Nigeria

Science.gov (United States)

Anyanwu, Joy; Ezenwaji, Ifeyinwa; Okenjom, Godian; Enyi, Chinwe

2015-01-01

The study aimed at finding out sources and symptoms of occupational stress and management strategies of principals in secondary schools in Cross River State, Nigeria. Descriptive survey research design was adopted for the study with a population of 420 principals (304 males and 116 females) in secondary schools in Cross River State, Nigeria. Three…

Numerical Analysis of the Influence of Clearance on Stress State and Contact Pressure in Plain Bearings

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Vasile Cojocaru

2017-12-01

Full Text Available In the analysis of plain bearings by finite element method it is important to model as closely to real state the aspects that influence the stress and contact pressure: the loading mode, the properties of the materials, the lubrication system, the clearance between the shaft and the bearing body, the evolution in time of clearance correlated with the wear, etc. In order to study the effect of the clearance on the stress state, a plain bearing with nominal diameter d=40 mm was modeled. The contact pressure and the equivalent stress were computed for six discrete values of clearance, range from c=0 to c=0.3 mm. It has been shown that the increase of clearance generates an increase of the equivalent stress and contact pressure. The growth rate is higher for contact pressure, due to the decrease of the contact surface between the shaft and the bearing body

Study of stress-strain state of pipeline under permafrost conditions

Science.gov (United States)

Tarasenko, A. A.; Redutinskiy, M. N.; Chepur, P. V.; Gruchenkova, A. A.

2018-05-01

In this paper, the dependences of the stress-strain state and subsidence of pipelines on the dimensions of the subsidence zone are obtained for the sizes of pipes that have become most widespread during the construction of main oil pipelines (530x10, 820x12, 1020x12, 1020x14, 1020x16, 1220x14, 1220x16, 1220x18 mm). True values of stresses in the pipeline wall, as well as the exact location of maximum stresses for the interval of subsidence zones from 5 to 60 meters, are determined. For this purpose, the authors developed a finite element model of the pipeline that takes into account the actual interaction of the pipeline with the subgrade and allows calculating the SSS of the structure for a variable subsidence zone. Based on the obtained dependences for the underground laying of oil pipelines in permafrost areas, it is proposed to artificially limit the zone of possible subsidence by separation supports from the soil with higher building properties and physical-mechanical parameters. This technical solution would significantly reduce costs when constructing new oil pipelines in permafrost areas.

Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex

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Débora Nunes Mario

Full Text Available Abstract INTRODUCTION: We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex. METHODS: Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen. RESULTS: Animals infected with S. brasiliensis exhibited splenomegaly and significant decrease in catalase activity, and protein and non-protein thiol content compared to animals infected with the other species. CONCLUSIONS: Sporothrix brasiliensis exhibits higher pathogenicity compared to other species of the Sporothrix schenckii complex by increasing oxidative stress in animal tissue.

INTEGRATED QUANTITATIVE ASSESSMENT OF CHANGES IN NEURO-ENDOCRINE-IMMUNE COMPLEX AND METABOLISM IN RATS EXPOSED TO ACUTE COLD-IMMOBILIZATION STRESS

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Sydoruk O Sydoruk

2016-09-01

    Abstracts Background. It is known that the reaction of the neuroendocrine-immune complex to acute and chronic stress are different. It is also known about sex differences in stress reactions. Previously we have been carry out integrated quantitative estimation of neuroendocrine and immune responses to chronic restraint stress at male rats. The purpose of this study - to carry out integrated quantitative estimation of neuroendocrine, immune and metabolic responses to acute stress at male and female rats. Material and research methods. The experiment is at 58 (28 male and 30 female white rats Wistar line weighing 170-280 g (Mean=220 g; SD=28 g. The day after acute (water immersion restraint stress determined HRV, endocrine, immune and metabolic parameters as well as gastric mucosa injuries and comparing them with parameters of intact animals. Results. Acute cold-immobilization stress caused moderate injuries the stomach mucosa as erosions and ulcers. Among the metabolic parameters revealed increased activity Acid Phosphatase, Asparagine and Alanine Aminotranspherase as well as Creatinephosphokinase. It was also found to reduce plasma Testosterone as well as serum Potassium and Phosphate probably due to increased Parathyrine and Mineralocorticoid activity and Sympathotonic shift of sympatho-vagal balance. Integrated quantitative measure manifestations of Acute Stress as mean of modules of Z-Scores makes for 10 metabolic parameters 0,75±0,10 σ and for 8 neuro-endocrine parameters 0,40±0,07 σ. Among immune parameters some proved resistant to acute stress factors, while 10 significant suppressed and 12 activated. Integrated quantitative measure poststressory changes makes 0,73±0,08 σ. Found significant differences integrated status intact males and females, whereas after stress differences are insignificant. Conclusion. The approach to integrated quantitative assessment of neuroendocrine-immune complex and metabolism may be useful for testing the

Numerical evaluation of state boundary surface through rotation of principal stress axes in sand

International Nuclear Information System (INIS)

Sadrnejad, S. A.

2001-01-01

In applying shear stress to saturated soil with arbitrary stress paths, the prediction of the exact value of strains is difficult because of mainly its stress path dependent nature. Rotation of the principal stress axes during shearing of the soil is a feature of stress paths associated with many field loading situations. A proper understanding of the effects of principal stress rotation on soil behavior can be provided if the anisotropy existing prior to stress rotation and induced anisotropy due to plastic flow in soil are clearly understood and modeled. A multi laminate based model for soil is developed and used to compute and present the influence of rotation of principal stress axes on the plastic behavior of soil. This is fulfilled by distributing the effects of boundary condition changes into several predefined sampling orientations at one point and summing the micro-results up as the macro-result. The validity of the presented model examined by comparing numerical and test results showing the mentioned aspect. In this paper, the state boundary surface is numerically obtained by a multi laminate based model capable of predicting the behavior of sand under the influences of rotation of the direction of principal stress axes and induced anisotropy. the predicted numerical results are tally in agreement with experiments

On a structural property in the state complexity of projected regular languages

Czech Academy of Sciences Publication Activity Database

Jirásková, G.; Masopust, Tomáš

2012-01-01

Roč. 449, Aug 31 (2012), s. 93-105 ISSN 0304-3975 R&D Projects: GA ČR(CZ) GPP202/11/P028 Institutional research plan: CEZ:AV0Z10190503 Institutional support: RVO:67985840 Keywords : projections * state complexity * descriptional complexity Subject RIV: BA - General Mathematics Impact factor: 0.489, year: 2012 http://www.sciencedirect.com/science/article/pii/S0304397512003532

Complexity in modeling of residual stresses and strains during polymerization of bone cement: effects of conversion, constraint, heat transfer, and viscoelastic property changes.

Science.gov (United States)

Gilbert, Jeremy L

2006-12-15

Aseptic loosening of cemented joint prostheses remains a significant concern in orthopedic biomaterials. One possible contributor to cement loosening is the development of porosity, residual stresses, and local fracture of the cement that may arise from the in-situ polymerization of the cement. In-situ polymerization of acrylic bone cement is a complex set of interacting processes that involve polymerization reactions, heat generation and transfer, full or partial mechanical constraint, evolution of conversion- and temperature-dependent viscoelastic material properties, and thermal and conversion-driven changes in the density of the cement. Interactions between heat transfer and polymerization can lead to polymerization fronts moving through the material. Density changes during polymerization can, in the presence of mechanical constraint, lead to the development of locally high residual strain energy and residual stresses. This study models the interactions during bone cement polymerization and determines how residual stresses develop in cement and incorporates temperature and conversion-dependent viscoelastic behavior. The results show that the presence of polymerization fronts in bone cement result in locally high residual strain energies. A novel heredity integral approach is presented to track residual stresses incorporating conversion and temperature dependent material property changes. Finally, the relative contribution of thermal- and conversion-dependent strains to residual stresses is evaluated and it is found that the conversion-based strains are the major contributor to the overall behavior. This framework provides the basis for understanding the complex development of residual stresses and can be used as the basis for developing more complex models of cement behavior.

Probing Stress States in Silicon Nanowires During Electrochemical Lithiation Using In Situ Synchrotron X-Ray Microdiffraction

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Imran Ali

2018-04-01

Full Text Available Silicon is considered as a promising anode material for the next-generation lithium-ion battery (LIB due to its high capacity at nanoscale. However, silicon expands up to 300% during lithiation, which induces high stresses and leads to fractures. To design silicon nanostructures that could minimize fracture, it is important to understand and characterize stress states in the silicon nanostructures during lithiation. Synchrotron X-ray microdiffraction has proven to be effective in revealing insights of mechanical stress and other mechanics considerations in small-scale crystalline structures used in many important technological applications, such as microelectronics, nanotechnology, and energy systems. In the present study, an in situ synchrotron X-ray microdiffraction experiment was conducted to elucidate the mechanical stress states during the first electrochemical cycle of lithiation in single-crystalline silicon nanowires (SiNWs in an LIB test cell. Morphological changes in the SiNWs at different levels of lithiation were also studied using scanning electron microscope (SEM. It was found from SEM observation that lithiation commenced predominantly at the top surface of SiNWs followed by further progression toward the bottom of the SiNWs gradually. The hydrostatic stress of the crystalline core of the SiNWs at different levels of electrochemical lithiation was determined using the in situ synchrotron X-ray microdiffraction technique. We found that the crystalline core of the SiNWs became highly compressive (up to -325.5 MPa once lithiation started. This finding helps unravel insights about mechanical stress states in the SiNWs during the electrochemical lithiation, which could potentially pave the path toward the fracture-free design of silicon nanostructure anode materials in the next-generation LIB.

Distinguishability of quantum states and shannon complexity in quantum cryptography

Science.gov (United States)

Arbekov, I. M.; Molotkov, S. N.

2017-07-01

The proof of the security of quantum key distribution is a rather complex problem. Security is defined in terms different from the requirements imposed on keys in classical cryptography. In quantum cryptography, the security of keys is expressed in terms of the closeness of the quantum state of an eavesdropper after key distribution to an ideal quantum state that is uncorrelated to the key of legitimate users. A metric of closeness between two quantum states is given by the trace metric. In classical cryptography, the security of keys is understood in terms of, say, the complexity of key search in the presence of side information. In quantum cryptography, side information for the eavesdropper is given by the whole volume of information on keys obtained from both quantum and classical channels. The fact that the mathematical apparatuses used in the proof of key security in classical and quantum cryptography are essentially different leads to misunderstanding and emotional discussions [1]. Therefore, one should be able to answer the question of how different cryptographic robustness criteria are related to each other. In the present study, it is shown that there is a direct relationship between the security criterion in quantum cryptography, which is based on the trace distance determining the distinguishability of quantum states, and the criterion in classical cryptography, which uses guesswork on the determination of a key in the presence of side information.

Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress.

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Reynolds K Brobey

Full Text Available The reactive oxygen species (ROS-sensitive apoptosis signal-regulating kinase 1 (ASK1 signaling complex is a key regulator of p38 MAPK activity, a major modulator of stress-associated with aging disorders. We recently reported that the ratio of free ASK1 to the complex-bound ASK1 is significantly decreased in Klotho-responsive manner and that Klotho-deficient tissues have elevated levels of free ASK1 which coincides with increased oxidative stress. Here, we tested the hypothesis that: 1 covalent interactions exist among three identified proteins constituting the ASK1 signaling complex; 2 in normal unstressed cells the ASK1, 14-3-3ζ and thioredoxin (Trx proteins simultaneously engage in a tripartite complex formation; 3 Klotho's stabilizing effect on the complex relied solely on 14-3-3ζ expression and its apparent phosphorylation and dimerization changes. To verify the hypothesis, we performed 14-3-3ζ siRNA knock-down experiments in conjunction with cell-based assays to measure ASK1-client protein interactions in the presence and absence of Klotho, and with or without an oxidant such as rotenone. Our results show that Klotho activity induces posttranslational modifications in the complex targeting 14-3-3ζ monomer/dimer changes to effectively protect against ASK1 oxidation and dissociation. This is the first observation implicating all three proteins constituting the ASK1 signaling complex in close proximity.

Populations of excited states and reaction mechanisms in the emission of complex fragments

International Nuclear Information System (INIS)

Gomez del Campo, J.

1990-01-01

Cross sections for emission of complex fragments (Z>2) in their ground and excited states are presented for several heavy-ion reactions at bombarding energies above 10 MeV/nucleon. Data presented are mostly on the cross sections extracted by γ-ray techniques. It is shown that a simple statistical approach to associate the ratio, of cross sections for excited states and ground states, to the temperature of the emitter fails to give the expected temperatures. However, it is shown that this is mostly due to the fact that the fragments that γ decay are secondary fragments, produced by the particle decay of the primary emitted complex fragments. A Hauser-Feshbach analysis accounts well for the cross sections and extracted temperatures. 22 refs., 6 figs

Stresses in Dolosse

DEFF Research Database (Denmark)

Burcharth, Hans F.; Liu, Zhou; Howell, Gary L.

1991-01-01

Failures of rubble mound breakwaters armoured with complex types of unreinforced concrete armour units are often due to breakage. This happens when the stresses exceed the material strength. Sufficient parametric studies of the stresses are not yet available to produce design diagrams for structu......Failures of rubble mound breakwaters armoured with complex types of unreinforced concrete armour units are often due to breakage. This happens when the stresses exceed the material strength. Sufficient parametric studies of the stresses are not yet available to produce design diagrams...... for structural integrity. The paper presents the results and the analyses of model tests with 200 kg and 200 g load-cell instrumented Dolosse. Static stresses and wave generated stresses were studied as well as model and scale effects. A preliminary design diagram for Dolosse is presented as well....

The State and the separation of powers

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Catalin-Silviu Sararu

2015-12-01

Full Text Available The State is a complex concept that can be addressed from a legal, political, social and economic perspective. The paper explores the meanings of the concept of State, State elements and stresses that the State power is one and indivisible and it is exercised through three functions and not to separate powers, namely the legislative function, executive function and the judicial function. The State institutions through which the three functions are controlled each other and collaborate to achieve the needs of society, which is likely to prevent abuses against citizens.

Altered mitochondrial function and oxidative stress in leukocytes of anorexia nervosa patients.

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Victor M Victor

Full Text Available CONTEXT: Anorexia nervosa is a common illness among adolescents and is characterised by oxidative stress. OBJECTIVE: The effects of anorexia on mitochondrial function and redox state in leukocytes from anorexic subjects were evaluated. DESIGN AND SETTING: A multi-centre, cross-sectional case-control study was performed. PATIENTS: Our study population consisted of 20 anorexic patients and 20 age-matched controls, all of which were Caucasian women. MAIN OUTCOME MEASURES: Anthropometric and metabolic parameters were evaluated in the study population. To assess whether anorexia nervosa affects mitochondrial function and redox state in leukocytes of anorexic patients, we measured mitochondrial oxygen consumption, membrane potential, reactive oxygen species production, glutathione levels, mitochondrial mass, and complex I and III activity in polymorphonuclear cells. RESULTS: Mitochondrial function was impaired in the leukocytes of the anorexic patients. This was evident in a decrease in mitochondrial O2 consumption (P<0.05, mitochondrial membrane potential (P<0.01 and GSH levels (P<0.05, and an increase in ROS production (P<0.05 with respect to control subjects. Furthermore, a reduction of mitochondrial mass was detected in leukocytes of the anorexic patients (P<0.05, while the activity of mitochondrial complex I (P<0.001, but not that of complex III, was found to be inhibited in the same population. CONCLUSIONS: Oxidative stress is produced in the leukocytes of anorexic patients and is closely related to mitochondrial dysfunction. Our results lead us to propose that the oxidative stress that occurs in anorexia takes place at mitochondrial complex I. Future research concerning mitochondrial dysfunction and oxidative stress should aim to determine the physiological mechanism involved in this effect and the physiological impact of anorexia.

Stress state of main stop valve with 500 mm nominal diameter white thermomechanical loading

International Nuclear Information System (INIS)

Koklyuev, G.A.; Plotnikov, V.P.

1987-01-01

The method of finite elements was applied to calculate the stress-strain state of the main isolation valve case with 500 mm nominal diameter while thermomechanical loading. Maximum stress takes place in the zone of joining nozzles with a spherical case and it attains the value of 138 MPa at working pressure of 12.5 MPa. The stress level in the point of nozzle-case welding is essentially lower than in zones of stres concentration and when excluding water hitting the slot of the lack of fusion in the route of the weld the weld service life is attained during the calculated service life

Reliability assessment of stress concentration performance state for a perforated composite plate under traction

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Jabbouri A.

2012-07-01

Full Text Available Considering a perforated sandwich plate made from two elastic homogenous and isotropic layers, and having a square hole, reliability assessment of stress concentration limit state for which the stress should not exceed a given threshold is performed in this work. Assuming that the plate dimensions and the applied loading are deterministic, focus is done on the square hole centre position and edge length considered to be random variables. The means and the standard deviations of these variables are assumed to be known, but no information is so far available about their densities of probabilities. To assess reliability of the performance state, reliability analysis known methods are applied to a response surface representation of the stress concentration factor of the perforated plate which is obtained through quadratic polynomial regression of finite element results. A parametric study is performed regarding the influence of the distributions of probabilities chosen to model the hole dimensions uncertainties. It is shown that the probability of failure depends largely on the selected densities of probabilities.

FMDV-induced stress granules are disrupted by the viral L-protease

DEFF Research Database (Denmark)

Polacek, Charlotta; Belsham, Graham; McInerney, Gerald

2014-01-01

Eukaryotic cells respond to environmental stress by entering a state of reduced protein synthesis, redirecting resources to damage control and defense. This reduced translation is closely linked to the formation of cytoplasmic stress granules (SGs). SGs are multicomponent foci, which contain...... stalled translation preinitiation complexes, including polyadenylated mRNAs, and several aggregation-prone RNA binding factors, such as the Ras-GAP SH3 domain-binding protein (G3BP) that enable their formation. Once the stress is lifted, the stalled complexes from the SGs are believed to re......-engage in translation, facilitating cellular recovery. A growing body of evidence shows that various viruses can trigger SG formation. However, the presence of SGs may not be beneficial to the virus and many viruses have found ways to circumvent, disrupt or even utilize these granules, suggesting a role for SGs...

DEPRESSION, ANXIETY, STRESS, AND THEIR ASSOCIATED FACTORS AMONG CORPS MEMBERS SERVING IN KEBBI STATE.

Science.gov (United States)

Balami, Ahmed D

2015-01-01

Depression, anxiety and stress, are not only health problems by themselves, but also associated with other negative health consequences. The national youth service is usually characterized by a number of new challenges and experiences which may require life style adjustments by the corps member. However, no previous study on psychological factors has been conducted among corps members. This study was conducted to determine the prevalence of depression, anxiety and, stress and their associated factors among corps members serving in Kebbi state. A cross-sectional study was conducted among 264 corps members from four local government areas of the state. Selection of the local government areas and the individual participants was by simple random sampling. Data was collected from May to June 2014 using a self-administered questionnaire. Data analysis used chi-square test to identify the relationship between categorical variables and multivariate logistic regression to identify the independent factors for depression, anxiety and stress each. The response rate was 97%. Most of the respondents were males (63.6%), single (85.5%), and above 20 years of age (71.6%). The overall prevalences of depression, anxiety and stress among the respondents were 36.4%, 54.5% and 18.2% respectively. The independent factors for depression were; being from the North central (OR = 5.99; 95% CI: 2.194-16.354) or South-south; and the perception of earning enough income (OR = 2.987; 95% CI: 1.062-8.400). For anxiety, male gender (OR = 0.411; 95% CI: 0.169-0.999); and being from the North central were significant risk factors (OR = 3.731; 95% CI: 1.450-9.599). Being above 26 years of age was an independent risk factor for stress (OR = 0.083; 95% CI: 0.018-0.381). Also, those who had ever schooled outside their towns of residence were less likely to be stressed compared to those who had never (OR = 0.30; 95% CI: 0.110-0.855). All other factors did not show any significant association with any of

Steady thermal stress and strain rates in a rotating circular cylinder under steady state temperature

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Pankaj Thakur

2014-01-01

Full Text Available Thermal stress and strain rates in a thick walled rotating cylinder under steady state temperature has been derived by using Seth’s transition theory. For elastic-plastic stage, it is seen that with the increase of temperature, the cylinder having smaller radii ratios requires lesser angular velocity to become fully plastic as compared to cylinder having higher radii ratios The circumferential stress becomes larger and larger with the increase in temperature. With increase in thickness ratio stresses must be decrease. For the creep stage, it is seen that circumferential stresses for incompressible materials maximum at the internal surface as compared to compressible material, which increase with the increase in temperature and measure n.

Characterization of degradation products of amorphous and polymorphic forms of clopidogrel bisulphate under solid state stress conditions

DEFF Research Database (Denmark)

Raijada, Dhara K; Prasad, Bhagwat; Paudel, Amrit

2010-01-01

The present study deals with the stress degradation studies on amorphous and polymorphic forms of clopidogrel bisulphate. The objective was to characterize the degradation products and postulate mechanism of decomposition of the drug under solid state stress conditions. For that, amorphous form, ...

Approximate analytical solutions in the analysis of elastic structures of complex geometry

Science.gov (United States)

Goloskokov, Dmitriy P.; Matrosov, Alexander V.

2018-05-01

A method of analytical decomposition for analysis plane structures of a complex configuration is presented. For each part of the structure in the form of a rectangle all the components of the stress-strain state are constructed by the superposition method. The method is based on two solutions derived in the form of trigonometric series with unknown coefficients using the method of initial functions. The coefficients are determined from the system of linear algebraic equations obtained while satisfying the boundary conditions and the conditions for joining the structure parts. The components of the stress-strain state of a bent plate with holes are calculated using the analytical decomposition method.

Role for ribosome-associated complex and stress-seventy subfamily B (RAC-Ssb) in integral membrane protein translation.

Science.gov (United States)

Acosta-Sampson, Ligia; Döring, Kristina; Lin, Yuping; Yu, Vivian Y; Bukau, Bernd; Kramer, Günter; Cate, Jamie H D

2017-12-01

Targeting of most integral membrane proteins to the endoplasmic reticulum is controlled by the signal recognition particle, which recognizes a hydrophobic signal sequence near the protein N terminus. Proper folding of these proteins is monitored by the unfolded protein response and involves protein degradation pathways to ensure quality control. Here, we identify a new pathway for quality control of major facilitator superfamily transporters that occurs before the first transmembrane helix, the signal sequence recognized by the signal recognition particle, is made by the ribosome. Increased rates of translation elongation of the N-terminal sequence of these integral membrane proteins can divert the nascent protein chains to the ribosome-associated complex and stress-seventy subfamily B chaperones. We also show that quality control of integral membrane proteins by ribosome-associated complex-stress-seventy subfamily B couples translation rate to the unfolded protein response, which has implications for understanding mechanisms underlying human disease and protein production in biotechnology. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

Simple and complex chimera states in a nonlinearly coupled oscillatory medium

Science.gov (United States)

Bolotov, Maxim; Smirnov, Lev; Osipov, Grigory; Pikovsky, Arkady

2018-04-01

We consider chimera states in a one-dimensional medium of nonlinear nonlocally coupled phase oscillators. In terms of a local coarse-grained complex order parameter, the problem of finding stationary rotating nonhomogeneous solutions reduces to a third-order ordinary differential equation. This allows finding chimera-type and other inhomogeneous states as periodic orbits of this equation. Stability calculations reveal that only some of these states are stable. We demonstrate that an oscillatory instability leads to a breathing chimera, for which the synchronous domain splits into subdomains with different mean frequencies. Further development of instability leads to turbulent chimeras.

Effect of surface stress state on dissolution property of Alloy 690 in simulated primary water condition

International Nuclear Information System (INIS)

Kim, Kyung Mo; Shim, Hee-Sang; Lee, Eun Hee; Seo, Myung Ji; Han, Jung Ho; Hur, Do Haeng

2014-01-01

The dissolution control of nickel is important to reduce the radioactive dose rate and deterioration of fuel performance in the operation of nuclear power plants (PWR). The corrosion properties are affected by the metal surface residual stress introduced in manufacture process such as work hardening. This work studied the effect of surface modification on the release rate of Alloy 690, nickel-base alloy for a steam generator tube, in the test condition of simulated primary water chemistry in PWRs. The surface stress modification was applied by the electro-polishing and shot peening method. Shot peening process was applied using ceramic beads with different intensities through the variation of air pressure. The corrosion release tests performed at 330degC with LiOH 2 ppm and H 3 BO 4 1200 ppm, DH(dissolved hydrogen) 35 cc/kg (STP) and about 20 ppb of DO(dissolved oxygen) condition. The corrosion release rate was evaluated by a gravimetric analysis method and the surface analysed by SEM and optical microscope. The surface residual stress was measured by an X-ray diffractometer, and the distribution of stress state was evaluated by a micro-hardness tester. The metal ion release rate of alloy 690 was evaluated from the influence of the stress state on the metal surface. The oxide property and structure was affected by the residual stress in the oxide layer. (author)

Infant temperament and parental stress in 3-month-old infants after surgery for complex congenital heart disease.

Science.gov (United States)

Torowicz, Deborah; Irving, Sharon Y; Hanlon, Alexandra L; Sumpter, Danica F; Medoff-Cooper, Barbara

2010-04-01

This study aimed to identify and compare differences in temperament and maternal stress between infants with complex congenital heart disease and healthy controls at 3 months of age. Study sample was drawn from an existing longitudinal study examining growth in infants with congenital heart disease when compared with healthy controls. Infant temperament and parental stress were measured in 129 mother-infant dyads. Inclusion criteria for infants with congenital heart disease were > or = 36-week postmenstrual age, > or = 2500 g at birth, surgery in first 6 weeks of life, and no major congenital anomalies or genetic syndromes. The Early Infancy Temperament Questionnaire and Parent Stress Index were the assessment tools used. Infants with single ventricular (SV) physiology were more negative in mood (F = 7.14, p parenting an irritable infant with SV physiology put these mothers at risk for high levels of stress. Results suggest the need for predischarge anticipatory guidance for parents to better understand and respond to the behavioral style of their infants, in particular, infants with SV physiology.

Study of the stress-strain state of compressed concrete elements with composite reinforcement

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Bondarenko Yurii

2017-01-01

Full Text Available The efficiency analysis of the application of glass composite reinforcement in compressed concrete elements as a load-carrying component has been performed. The results of experimental studies of the deformation-strength characteristics of this reinforcement on compression and compressed concrete cylinders reinforced by this reinforcement are presented. The results of tests and mechanisms of sample destruction have been analyzed. The numerical analysis of the stress-strain state has been performed for axial compression of concrete elements with glasscomposite reinforcement. The influence of the reinforcement percentage on the stressed state of a concrete compressed element with the noted reinforcement is estimated. On the basis of the obtained results, it is established that the glass-composite reinforcement has positive effect on the strength of the compressed concrete elements. That is, when calculating the load-bearing capacity of such structures, the function of composite reinforcement on compression should not be neglected.

The Importance of the Oil and Gas Complex for the Brazilian Economy and Its States

OpenAIRE

Guilhoto, Joaquim Jose Martins; Ichihara, Silvio Massaru; Postali, Fernando Antonio Slaibe

2006-01-01

This paper presents the results of a research conducted to measure the importance of the oil and gas complex in the Brazilian economy and in its states. Initially, the efforts were concentrated in the construction of an interregional input-output system for the 27 states of the Brazilian economy at the level of 42 industries, for the year of 2002. Using this system it was possible to make an analysis of role played by the oil and gas complex in the Brazilian economy and its states. First it i...

Nutritional mitigation of winter thermal stress in gilthead seabream associated metabolic pathways and potential indicators of nutritional state

DEFF Research Database (Denmark)

Richard, Nadege; Silva, Tomé S.; Wulff, Tune

2016-01-01

and phenylalanine/tyrosine catabolism, and induced higher aerobic metabolism and gluconeogenesis. Results support the notion that WF diet had a positive effect on fish nutritional state by partially counteracting the effect of thermal stress and underlined the sensitivity of proteome data for nutritional....... A total of 404 protein spots, out of 1637 detected, were differentially expressed between the two groups of fish. Mass spectrometry analysis of selected spots suggested that WF diet improved oxidative stress defense, reduced endoplasmic reticulum stress, enhanced metabolic flux through methionine cycle...... and metabolic profiling purposes. Intragroup variability and co-measured information were also used to pinpoint which proteins displayed a stronger relation with fish nutritional state....

Seismicity and stress state in the South China Sea, Indochina and their vicinity

Science.gov (United States)

Zang, Shaoxian; Wu, Zhongliang; Li, Aibing

1992-02-01

The distribution of earthquakes from 1973 to 1982 in the South China Sea, Indochina and their vicinity was studied using the data from I. S. C. It was found that the earthquakes are mainly concentrated along the boundaries of plates. Beside, some of shallow eartqhuakes are distributed in west part of Burma and the boundary between Burma and China, a few of earthquakes occurred in South China Sea. The features of Benioff zone along the boundaries between India plate, Philippine Sea plate and Eurasia plate were studied. The plate do not coupled well under the Java trench and the Philippine trench. The subducted India plate under Burmese range, Andaman—Nicobar arc moves NNE. The fault plane solutions of earthquakes were studied using the first motions of P wave. The stress state on subduction zones and within the area were deduced from the fault plane solutions and the fault movement. It was found that the direction of principal compression axis of stress is in the NNE in west part of Burma, in S—N in south and middle part of Bruma and Thailand, and in NNE or S—N in the South China Sea. It was also found that the stress state has close relation with the interaction of plates.

Effect of different pneumoperitoneum pressure on stress state in patients underwent gynecological laparoscopy

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Ai-Yun Shen

2016-10-01

Full Text Available Objective: To observe the effect of different CO2 pneumoperitoneum pressure on the stress state in patients underwent gynecological laparoscopy. Methods: A total of 90 patients who were admitted in our hospital from February, 2015 to October, 2015 for gynecological laparoscopy were included in the study and divided into groups A, B, and C according to different CO2 pneumoperitoneum pressure. The changes of HR, BP, and PetCO2 during the operation process in the three groups were recorded. The changes of stress indicators before operation (T0, 30 min during operation (T1, and 12 h after operation (T2 were compared. Results: The difference of HR, BP, and PetCO2 levels before operation among the three groups was not statistically significant (P>0.05. HR, BP, and PetCO2 levels 30 min after pneumoperitoneum were significantly elevated when compared with before operation (P0.05. PetCO2 level 30 min after pneumoperitoneum in group B was significantly higher than that in group A (P0.05. Conclusions: Low pneumoperitoneum pressure has a small effect on the stress state in patients underwent gynecological laparoscopy, will not affect the surgical operation, and can obtain a preferable muscular relaxation and vision field; therefore, it can be selected in preference.

Depression, Anxiety, and Stress Symptoms in Menopausal Arab Women: Shedding More Light on a Complex Relationship.

Science.gov (United States)

Bener, A; Saleh, N M; Bakir, A; Bhugra, D

2016-01-01

The association between depression, anxiety, and stress among Arab menopause and postmenopausal women have been explored in detailed. The objective of this study was to determine the correlation between depression, anxiety, and stress in menopausal and postmenopausal women and shedding more light on a complex relationship. A cross-sectional descriptive study was used to generate menopause symptoms experienced by Arabian women at the primary health care centers in Qatar. A representative sample of 1468 women aged 45-65 years were approached during July 2012 and May 2014 and 1101 women agreed to participate (75.0%) and responded to the study. Depression, anxiety, and stress were measured using the Depression Anxiety Stress Scales 21. Data on body mass index (BMI), clinical and other parameters were used. Univariate, multivariate, and matrix correlation analysis were performed for statistical analysis. A total of 1101 women agreed to participate after informed consent was obtained. The mean age and standard deviation (SD) of the menopausal age were 49.55 (3.12), the mean and SD of postmenopausal age was 58.08 (3.26) ( P stress among menopause and postmenopause. The multivariate regression analyses revealed that age in years, diastolic BP, consanguinity, regular exercise were a predictor for depression. Meanwhile, diastolic BP, occupation, and physical activity considered the main risk factors for anxiety. Furthermore, age in years, occupation, and sheesha smoking habits were considered as the main risk factors associated with stress. A large number of factors were associated with experiencing menopausal and psycho-social problems and which had negative effects on the quality of life among Arabian women. Depression, anxiety, and stress should be considered as important risk factors for osteoporosis.

Thermographic Analysis of Stress Distribution in Welded Joints

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Domazet Ž.

2010-06-01

Full Text Available The fatigue life prediction of welded joints based on S-N curves in conjunction with nominal stresses generally is not reliable. Stress distribution in welded area affected by geometrical inhomogeneity, irregular welded surface and weld toe radius is quite complex, so the local (structural stress concept is accepted in recent papers. The aim of this paper is to determine the stress distribution in plate type aluminum welded joints, to analyze the reliability of TSA (Thermal Stress Analysis in this kind of investigations, and to obtain numerical values for stress concentration factors for practical use. Stress distribution in aluminum butt and fillet welded joints is determined by using the three different methods: strain gauges measurement, thermal stress analysis and FEM. Obtained results show good agreement - the TSA mutually confirmed the FEM model and stresses measured by strain gauges. According to obtained results, it may be stated that TSA, as a relatively new measurement technique may in the future become a standard tool for the experimental investigation of stress concentration and fatigue in welded joints that can help to develop more accurate numerical tools for fatigue life prediction.

Thermographic Analysis of Stress Distribution in Welded Joints

Science.gov (United States)

Piršić, T.; Krstulović Opara, L.; Domazet, Ž.

2010-06-01

The fatigue life prediction of welded joints based on S-N curves in conjunction with nominal stresses generally is not reliable. Stress distribution in welded area affected by geometrical inhomogeneity, irregular welded surface and weld toe radius is quite complex, so the local (structural) stress concept is accepted in recent papers. The aim of this paper is to determine the stress distribution in plate type aluminum welded joints, to analyze the reliability of TSA (Thermal Stress Analysis) in this kind of investigations, and to obtain numerical values for stress concentration factors for practical use. Stress distribution in aluminum butt and fillet welded joints is determined by using the three different methods: strain gauges measurement, thermal stress analysis and FEM. Obtained results show good agreement - the TSA mutually confirmed the FEM model and stresses measured by strain gauges. According to obtained results, it may be stated that TSA, as a relatively new measurement technique may in the future become a standard tool for the experimental investigation of stress concentration and fatigue in welded joints that can help to develop more accurate numerical tools for fatigue life prediction.

Modeling and stress analyses of a normal foot-ankle and a prosthetic foot-ankle complex.

Science.gov (United States)

Ozen, Mustafa; Sayman, Onur; Havitcioglu, Hasan

2013-01-01

Total ankle replacement (TAR) is a relatively new concept and is becoming more popular for treatment of ankle arthritis and fractures. Because of the high costs and difficulties of experimental studies, the developments of TAR prostheses are progressing very slowly. For this reason, the medical imaging techniques such as CT, and MR have become more and more useful. The finite element method (FEM) is a widely used technique to estimate the mechanical behaviors of materials and structures in engineering applications. FEM has also been increasingly applied to biomechanical analyses of human bones, tissues and organs, thanks to the development of both the computing capabilities and the medical imaging techniques. 3-D finite element models of the human foot and ankle from reconstruction of MR and CT images have been investigated by some authors. In this study, data of geometries (used in modeling) of a normal and a prosthetic foot and ankle were obtained from a 3D reconstruction of CT images. The segmentation software, MIMICS was used to generate the 3D images of the bony structures, soft tissues and components of prosthesis of normal and prosthetic ankle-foot complex. Except the spaces between the adjacent surface of the phalanges fused, metatarsals, cuneiforms, cuboid, navicular, talus and calcaneus bones, soft tissues and components of prosthesis were independently developed to form foot and ankle complex. SOLIDWORKS program was used to form the boundary surfaces of all model components and then the solid models were obtained from these boundary surfaces. Finite element analyses software, ABAQUS was used to perform the numerical stress analyses of these models for balanced standing position. Plantar pressure and von Mises stress distributions of the normal and prosthetic ankles were compared with each other. There was a peak pressure increase at the 4th metatarsal, first metatarsal and talus bones and a decrease at the intermediate cuneiform and calcaneus bones, in

New insights into roles of acidocalcisomes and contractile vacuole complex in osmoregulation in protists.

Science.gov (United States)

Docampo, Roberto; Jimenez, Veronica; Lander, Noelia; Li, Zhu-Hong; Niyogi, Sayantanee

2013-01-01

While free-living protists are usually subjected to hyposmotic environments, parasitic protists are also in contact with hyperosmotic habitats. Recent work in one of these parasites, Trypanosoma cruzi, has revealed that its contractile vacuole complex, which usually collects and expels excess water as a mechanism of regulatory volume decrease after hyposmotic stress, has also a role in cell shrinking when the cells are submitted to hyperosmotic stress. Trypanosomes also have an acidic calcium store rich in polyphosphate (polyP), named the acidocalcisome, which is involved in their response to osmotic stress. Here, we review newly emerging insights on the role of acidocalcisomes and the contractile vacuole complex in the cellular response to hyposmotic and hyperosmotic stresses. We also review the current state of knowledge on the composition of these organelles and their other roles in calcium homeostasis and protein trafficking. © 2013, Elsevier Inc. All Rights Reserved.

Ferrous sulfate, but not iron polymaltose complex, aggravates local and systemic inflammation and oxidative stress in dextran sodium sulfate-induced colitis in rats

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Toblli JE

2015-05-01

Full Text Available Jorge E Toblli, Gabriel Cao, Margarita Angerosa Laboratory of Experimental Medicine, Hospital Alemán, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina Background and aims: Iron deficiency is common in inflammatory bowel disease, yet oral iron therapy may worsen the disease symptoms and increase systemic and local oxidative stress. The aim of this study was to compare the effects of oral ferrous sulfate and iron polymaltose complex on inflammatory and oxidative stress markers in colitic rats.Methods: Animals were divided into four groups with ten animals each. Rats of three groups received dextran sodium sulfate to induce colitis and animals of two of these groups received 5 mg iron/kg of body weight a day, as ferrous sulfate or iron polymaltose complex, for 7 days. Gross colon anatomy, histology of colon and liver, stainings of L-ferritin, Prussian blue, hepcidin, tumor necrosis factor-α, and interleukin-6, as well serum levels of liver enzymes, inflammatory markers, and iron markers, were assessed.Results: Body weight, gross anatomy, crypt injury and inflammation scores, inflammatory parameters in liver and colon, as well as serum and liver hepcidin levels were not significantly different between colitic animals without iron treatment and colitic animals treated with iron polymaltose complex. In contrast, ferrous sulfate treatment caused significant worsening of these parameters. As opposed to ferrous sulfate, iron polymaltose complex caused less or no additional oxidative stress in the colon and liver compared to colitic animals without iron treatment.Conclusion: Iron polymaltose complex had negligible effects on colonic tissue erosion, local or systemic oxidative stress, and local or systemic inflammation, even at high therapeutic doses, and may thus represent a valuable oral treatment of iron deficiency in inflammatory bowel disease. Keywords: preclinical, oral iron treatment, tolerability, colonic tissue erosion

Steady-state and transient heat transfer through fins of complex geometry

Directory of Open Access Journals (Sweden)

Taler Dawid

2014-06-01

Full Text Available Various methods for steady-state and transient analysis of temperature distribution and efficiency of continuous-plate fins are presented. For a constant heat transfer coefficient over the fin surface, the plate fin can be divided into imaginary rectangular or hexangular fins. At first approximate methods for determining the steady-state fin efficiency like the method of equivalent circular fin and the sector method are discussed. When the fin geometry is complex, thus transient temperature distribution and fin efficiency can be determined using numerical methods. A numerical method for transient analysis of fins with complex geometry is developed. Transient temperature distributions in continuous fins attached to oval tubes is computed using the finite volume - finite element methods. The developed method can be used in the transient analysis of compact heat exchangers to calculate correctly the heat flow rate transferred from the finned tubes to the fluid.

Complex projection of unitary dynamics of quaternionic pure states

International Nuclear Information System (INIS)

Asorey, M.; Scolarici, G.; Solombrino, L.

2007-01-01

Quaternionic quantum mechanics has been revealed to be a very useful framework to describe quantum phenomena. In the case of two qubit compound systems we show that the complex projection of quaternionic pure states and quaternionic unitary maps permits the description of interesting phenomena such as decoherence and optimal entanglement generation. The approach, however, presents severe limitations for the case of multipartite or higher dimensional bipartite quantum systems as we point out

Neuroendocrine and oxidoreductive mechanisms of stress-induced cardiovascular diseases.

Science.gov (United States)

Pajović, S B; Radojcić, M B; Kanazir, D T

2008-01-01

The review concerns a number of basic molecular pathways that play a crucial role in perception, transmission, and modulation of the stress signals, and mediate the adaptation of the vital processes in the cardiovascular system (CVS). These highly complex systems for intracellular transfer of information include stress hormones and their receptors, stress-activated phosphoprotein kinases, stress-activated heat shock proteins, and antioxidant enzymes maintaining oxidoreductive homeostasis of the CVS. Failure to compensate for the deleterious effects of stress may result in the development of different pathophysiological states of the CVS, such as ischemia, hypertension, atherosclerosis and infarction. Stress-induced dysbalance in each of the CVS molecular signaling systems and their contribution to the CVS malfunctioning is reviewed. The general picture of the molecular mechanisms of the stress-induced pathophysiology in the CVS pointed out the importance of stress duration and intensity as etiological factors, and suggested that future studies should be complemented by the careful insights into the individual factors of susceptibility to stress, prophylactic effects of 'healthy' life styles and beneficial action of antioxidant-rich nutrition.

Stress-induced resistance to the fear memory labilization/reconsolidation process. Involvement of the basolateral amygdala complex.

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Espejo, Pablo Javier; Ortiz, Vanesa; Martijena, Irene Delia; Molina, Victor Alejandro

2016-10-01

Consolidated memories can enter into a labile state after reactivation followed by a restabilization process defined as reconsolidation. This process can be interfered with Midazolam (MDZ), a positive allosteric modulator of the GABA-A receptor. The present study has evaluated the influence of prior stress on MDZ's interfering effect. We also assessed the influence of both systemic and intra-basolateral amygdala (BLA) infusion of d-cycloserine (DCS), a partial agonist of the NMDA receptors, on the MDZ effect in previously stressed rats. Furthermore, we analyzed the effect of stress on the expression of Zif-268 and the GluN2B sites, two molecular markers of the labilization/reconsolidation process, following reactivation. The results revealed that prior stress resulted into a memory trace that was insensitive to the MDZ impairing effect. Both systemic and intra-BLA DCS administration previous to reactivation restored MDZ's disruptive effect on memory reconsolidation in stressed animals. Further, reactivation enhanced Zif-268 expression in the BLA in control unstressed rats, whereas no elevation was observed in stressed animals. In agreement with the behavioral findings, DCS restored the increased level of Zif-268 expression in the BLA in stressed animals. Moreover, memory reactivation in unstressed animals elevated GluN2B expression in the BLA, thus suggesting that this effect is involved in memory destabilization, whereas stressed animals did not reveal any changes. These findings are consistent with resistance to the MDZ effect in these rats, indicating that stress exposure prevents the onset of destabilization following reactivation. In summary, prior stress limited both the occurrence of the reactivation-induced destabilization and restabilization. Copyright © 2016 Elsevier Ltd. All rights reserved.

The influence of stress on fear memory processes

Directory of Open Access Journals (Sweden)

I.D. Martijena

2012-04-01

Full Text Available It is well recognized that stressful experiences promote robust emotional memories, which are well remembered. The amygdaloid complex, principally the basolateral complex (BLA, plays a pivotal role in fear memory and in the modulation of stress-induced emotional responses. A large number of reports have revealed that GABAergic interneurons provide a powerful inhibitory control of the activity of projecting glutamatergic neurons in the BLA. Indeed, a reduced GABAergic control in the BLA is essential for the stress-induced influence on the emergence of associative fear memory and on the generation of long-term potentiation (LTP in BLA neurons. The extracellular signal-regulated kinase (ERK subfamily of the mitogen-activated protein kinase (MAPK signaling pathway in the BLA plays a central role in the consolidation process and synaptic plasticity. In support of the view that stress facilitates long-term fear memory, stressed animals exhibited a phospho-ERK2 (pERK2 increase in the BLA, suggesting the involvement of this mechanism in the promoting influence of threatening stimuli on the consolidation fear memory. Moreover, the occurrence of reactivation-induced lability is prevented when fear memory is encoded under intense stressful conditions since the memory trace remains immune to disruption after recall in previously stressed animals. Thus, the underlying mechanism in retrieval-induced instability seems not to be functional in memories formed under stress. All these findings are indicative that stress influences both the consolidation and reconsolidation fear memory processes. Thus, it seems reasonable to propose that the emotional state generated by an environmental challenge critically modulates the formation and maintenance of long-term fear memory.

Stress state reconstruction and tectonic evolution of the northern slope of the Baikit anteclise, Siberian Craton, based on 3D seismic data

Science.gov (United States)

Moskalenko, A. N.; Khudoley, A. K.; Khusnitdinov, R. R.

2017-05-01

In this work, we consider application of an original method for determining the indicators of the tectonic stress fields in the northern Baikit anteclise based on 3D seismic data for further reconstruction of the stress state parameters when analyzing structural maps of seismic horizons and corresponded faults. The stress state parameters are determined by the orientations of the main stress axes and shape of the stress ellipsoid. To calculate the stress state parameters from data on the spatial orientations of faults and slip vectors, we used the algorithms from quasiprimary stress computation methods and cataclastic analysis, implemented in the software products FaultKinWin and StressGeol, respectively. The results of this work show that kinematic characteristics of faults regularly change toward the top of succession and that the stress state parameters are characterized by different values of the Lode-Nadai coefficient. Faults are presented as strike-slip faults with normal or reverse component of displacement. Three stages of formation of the faults are revealed: (1) partial inversion of ancient normal faults, (2) the most intense stage with the predominance of thrust and strike-slip faults at north-northeast orientation of an axis of the main compression, and (3) strike-slip faults at the west-northwest orientation of an axis of the main compression. The second and third stages are pre-Vendian in age and correlate to tectonic events that took place during the evolution of the active southwestern margin of the Siberian Craton.

Modelling of Octahedral Manganese II Complexes with Inorganic Ligands: A Problem with Spin-States

Directory of Open Access Journals (Sweden)

Ludwik Adamowicz

2003-08-01

Full Text Available Abstract: Quantum mechanical ab initio UHF, MP2, MC-SCF and DFT calculations with moderate Gaussian basis sets were performed for MnX6, X = H2O, F-, CN-, manganese octahedral complexes. The correct spin-state of the complexes was obtained only when the counter ions neutralizing the entire complexes were used in the modelling at the B3LYP level of theory.

State anxiety, psychological stress and positive well-being responses to yoga and aerobic exercise in people with schizophrenia: a pilot study.

Science.gov (United States)

Vancampfort, Davy; De Hert, Marc; Knapen, Jan; Wampers, Martien; Demunter, Hella; Deckx, Seppe; Maurissen, Katrien; Probst, Michel

2011-01-01

Worsening of schizophrenia symptoms is related to stress and anxiety. People with schizophrenia often experience difficulties in coping with stress and possess a limited repertoire of coping strategies. A randomised comparative trial was undertaken in patients with schizophrenia to evaluate changes in state anxiety, psychological stress and subjective well-being after single sessions of yoga and aerobic exercise compared with a control condition. Forty participants performed a single 30-min yoga session, 20-min of aerobic exercise on a bicycle ergometre at self-selected intensity and a 20-min no exercise control condition in random order. After single sessions of yoga and aerobic exercise individuals with schizophrenia or schizoaffective disorder showed significantly decreased state anxiety (p stress (p exercise control condition. Effect sizes ranged from 0.82 for psychological stress after aerobic exercise to 1.01 for state anxiety after yoga. The magnitude of the changes did not differ significantly between yoga and aerobic exercise. People with schizophrenia and physiotherapists can choose either yoga or aerobic exercise in reducing acute stress and anxiety taking into account the personal preference of each individual.

Charge-Transfer Dynamics in the Lowest Excited State of a Pentacene–Fullerene Complex: Implications for Organic Solar Cells

KAUST Repository

Joseph, Saju

2017-10-02

We characterize the dynamic nature of the lowest excited state in a pentacene/C60 complex on the femtosecond time scale, via a combination of ab initio molecular dynamics and time-dependent density functional theory. We analyze the correlations between the molecular vibrations of the complex and the oscillations in the electron-transfer character of its lowest excited state, which point to vibration-induced coherences between the (pentacene-based) local-excitation (LE) state and the complex charge-transfer (CT) state. We discuss the implications of our results on this model system for the exciton-dissociation process in organic solar cells.

Software for determining the direction of movement, shear and normal stresses of a fault under a determined stress state

Science.gov (United States)

Álvarez del Castillo, Alejandra; Alaniz-Álvarez, Susana Alicia; Nieto-Samaniego, Angel Francisco; Xu, Shunshan; Ochoa-González, Gil Humberto; Velasquillo-Martínez, Luis Germán

2017-07-01

In the oil, gas and geothermal industry, the extraction or the input of fluids induces changes in the stress field of the reservoir, if the in-situ stress state of a fault plane is sufficiently disturbed, a fault may slip and can trigger fluid leakage or the reservoir might fracture and become damaged. The goal of the SSLIPO 1.0 software is to obtain data that can reduce the risk of affecting the stability of wellbores. The input data are the magnitudes of the three principal stresses and their orientation in geographic coordinates. The output data are the slip direction of a fracture in geographic coordinates, and its normal (σn) and shear (τ) stresses resolved on a single or multiple fracture planes. With this information, it is possible to calculate the slip tendency (τ/σn) and the propensity to open a fracture that is inversely proportional to σn. This software could analyze any compressional stress system, even non-Andersonian. An example is given from an oilfield in southern Mexico, in a region that contains fractures formed in three events of deformation. In the example SSLIPO 1.0 was used to determine in which deformation event the oil migrated. SSLIPO 1.0 is an open code application developed in MATLAB. The URL to obtain the source code and to download SSLIPO 1.0 are: http://www.geociencias.unam.mx/ alaniz/main_code.txt, http://www.geociencias.unam.mx/ alaniz/ SSLIPO_pkg.exe.

Stress among Accounting Educators in the United States.

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Seiler, Robert E.; Pearson, Della A.

1984-01-01

Stress among accounting educators was investigated and relationships between stress levels and work satisfaction levels, personality traits, and stress-coping techniques were examined. The most important personality charcteristics of higher stress individuals were impatience, assertiveness, workaholism, and idealism. (Author/MLW)

New Insights into the Roles of Acidocalcisomes and the Contractile Vacuole Complex in Osmoregulation in Protists

Science.gov (United States)

Docampo, Roberto; Jimenez, Veronica; Lander, Noelia; Li, Zhu-Hong; Niyogi, Sayantanee

2013-01-01

While free-living protists are usually subjected to hyposmotic environments, parasitic protists are also in contact with hyperosmotic habitats. Recent work in one of these parasites, Trypanosoma cruzi, has revealed that its contractile vacuole complex, which usually collects and expels excess water as a mechanism of regulatory volume decrease after hyposmotic stress, has also a role in cell shrinking when the cells are submitted to hyperosmotic stress. Trypanosomes also have an acidic calcium store rich in polyphosphate (polyP), named the acidocalcisome, which is involved in their response to osmotic stress. Here, we review newly emerging insights on the role of acidocalcisomes and the contractile vacuole complex in the cellular response to hyposmotic and hyperosmotic stresses. We also review the current state of knowledge on the composition of these organelles and their other roles in calcium homeostasis and protein trafficking. PMID:23890380

Regional homogeneity and resting state functional connectivity: associations with exposure to early life stress.

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Philip, Noah S; Kuras, Yuliya I; Valentine, Thomas R; Sweet, Lawrence H; Tyrka, Audrey R; Price, Lawrence H; Carpenter, Linda L

2013-12-30

Early life stress (ELS) confers risk for psychiatric illness. Previous literature suggests ELS is associated with decreased resting-state functional connectivity (rs-FC) in adulthood, but there are no studies of resting-state neuronal activity in this population. This study investigated whether ELS-exposed individuals demonstrate resting-state activity patterns similar to those found in PTSD. Twenty-seven adults (14 with at least moderate ELS), who were medication-free and without psychiatric or medical illness, underwent MRI scans during two 4-minute rest periods. Resting-state activity was examined using regional homogeneity (ReHo), which estimates regional activation patterns through indices of localized concordance. ReHo values were compared between groups, followed by rs-FC analyses utilizing ReHo-localized areas as seeds to identify other involved regions. Relative to controls, ELS subjects demonstrated diminished ReHo in the inferior parietal lobule (IPL) and superior temporal gyrus (STG). ReHo values were inversely correlated with ELS severity. Secondary analyses revealed decreased rs-FC between the IPL and right precuneus/posterior cingulate, left fusiform gyrus, cerebellum and caudate in ELS subjects. These findings indicate that ELS is associated with altered resting-state activity and connectivity in brain regions involved in trauma-related psychiatric disorders. Future studies are needed to evaluate whether these associations represent potential imaging biomarkers of stress exposure. Published by Elsevier Ireland Ltd.

Onset of posttraumatic stress disorder and major depression among refugees and voluntary migrants to the United States.

Science.gov (United States)

Rasmussen, Andrew; Crager, Mia; Baser, Ray E; Chu, Tracy; Gany, Francesca

2012-12-01

Although refugees are generally thought to be at increased risk for posttraumatic stress disorder (PTSD) and major depressive episode (MDE), few studies have compared onset of PTSD and MDE between refugees and voluntary migrants. Given differences in migration histories, onset should differ pre- and postmigration. The National Latino and Asian American Survey (NLAAS) is a national representative, complex dataset measuring psychiatric morbidity, mental health service use, and migration history among Latino and Asian immigrants to the United States. Of the 3,260 foreign-born participants, 660 were refugees (a weighted proportion of 9.52%). Refugees were more likely to report a history of war-related trauma, but reports of other traumatic events were similar. Premigration onset of PTSD was statistically higher for refugees than voluntary migrants, odds ratio (OR) = 4.86, 95% confidence interval (CI) [2.01, 11.76], where postmigration onset for PTSD was not, OR = 0.61, 95% CI [0.29, 1.28]; a similar pattern was found for MDE, OR = 1.98, 95% CI [1.11, 3.51]; and OR = 1.02, 95% CI [0.65, 1.62], respectively. Although refugees arrive in host countries with more pressing psychiatric needs, onset is comparable over time, suggesting that postmigration refugees and voluntary migrants may be best served by similar programs. Copyright © 2012 International Society for Traumatic Stress Studies.

Minmax defense strategy for complex multi-state systems

International Nuclear Information System (INIS)

Hausken, Kjell; Levitin, Gregory

2009-01-01

This paper presents a general optimization methodology that merges game theory and multi-state system survivability theory. The defender has multiple alternatives of defense strategy that presumes separation and protection of system elements. The attacker also has multiple alternatives of its attack strategy based on a combination of different possible attack actions against different groups of system elements. The defender minimizes, and the attacker maximizes, the expected damage caused by the attack (taking into account the unreliability of system elements and the multi-state nature of complex series-parallel systems). The problem is defined as a two-period minmax non-cooperative game between the defender who moves first and the attacker who moves second. An exhaustive minmax optimization algorithm is presented based on a double-loop genetic algorithm for determining the solution. A universal generating function technique is applied for evaluating the losses caused by system performance reduction. Illustrative examples with solutions are presented

THO/TREX complex

KAUST Repository

Dö ll, Stefanie; Kuhlmann, Markus; Rutten, Twan; Mette, Michael F.; Scharfenberg, Sarah; Petridis, Antonios; Berreth, Dorothee-Carina; Mock, Hans-Peter

2017-01-01

Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that scopolin accumulation can be induced in the root by osmotic stress and in the leaf by low-temperature stress in Arabidopsis thaliana. A genetic screen for altered scopolin levels in A. thaliana revealed a mutant compromised in scopolin accumulation in response to stress; the lesion was present in a homologue of THO1 coding for a subunit of the THO/TREX complex. The THO/TREX complex contributes to RNA silencing, supposedly by trafficking precursors of small RNAs. Mutants defective in THO, AGO1, SDS3 and RDR6 were impaired with respect to scopolin accumulation in response to stress, suggesting a mechanism based on RNA silencing such as the trans-acting small interfering RNA pathway, which requires THO/TREX function.

Stress states in the Zagros fold-and-thrust belt from passive margin to collisional tectonic setting

Science.gov (United States)

Navabpour, Payman; Barrier, Eric

2012-12-01

The present-day Zagros fold-and-thrust belt of SW-Iran corresponds to the former Arabian passive continental margin of the southern Neo-Tethyan basin since the Permian-Triassic rifting, undergoing later collisional deformation in mid-late Cenozoic times. In this paper an overview of brittle tectonics and palaeostress reconstructions of the Zagros fold-and-thrust belt is presented, based on direct stress tensor inversion of fault slip data. The results indicate that, during the Neo-Tethyan oceanic opening, an extensional tectonic regime affectedthe sedimentary cover in Triassic-Jurassic times with an approximately N-S trend of the σ3 axis, oblique to the margin, which was followed by some local changes to a NE-SW trend during Jurassic-Cretaceous times. The stress state significantly changed to thrust setting, with a NE-SW trend of the σ1 axis, and a compressional tectonic regime prevailed during the continental collision and folding of the sedimentary cover in Oligocene-Miocene times. This compression was then followed by a strike-slip stress state with an approximately N-S trend of the σ1 axis, oblique to the belt, during inversion of the inherited extensional basement structures in Pliocene-Recent times. The brittle tectonic reconstructions, therefore, highlighted major changes of the stress state in conjunction with transitions between thin- and thick-skinned structures during different extensional and compressional stages of continental deformation within the oblique divergent and convergent settings, respectively.

The study of the functional state of the endothelium via a complex of markers with reactive hyperemia

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Berezhniy V.

2016-03-01

Full Text Available Diagnosis of endothelial dysfunction is a key point in the prevention and treatment of cardiovascular diseases. In scientific research the study of the state of the endothelium used test with reactive hyperemia of brachial artery wich present as the value of endothelium dependent and independent artery dilatation. However, the disadvantage of this marker is ignoring the size of arteries, well know that small arteries has a greater degree of dilation more than big arterias, this fact making difficult to compare results between different patients. The aim of our study was to examine the state of endothelium using a complex of markers, compare them informative in children with JRA who are at risk for the development of endothelial dysfunction. Materials and Methods. The study was included 40 children with juvenile rheumatoid arthritis who were treated at the department of children's cardiorheumatology Kyiv City Children's Hospital #1 and Kiev Regional Hospital m. Boyarka. Results. The study found a development of endothelial dysfunction changes in endothelium dependent vasodilation, reactive hyperemia and coefficient of vasodilation. Simultaneous marked change of endothelium vasodilation of the brachial artery and coefficient of vasodilatation. There were no pathological changes in endothelial shear stress in patients compared with healthy children. Conclusions. Evaluate the state of the endothelium is necessary with the help of a set of indicators (RH, EDVD, VC that will help to avoid diagnostic mistakes during the test with the reactive hyperemia.

The state of stress in British rocks

International Nuclear Information System (INIS)

Klein, R.J.; Brown, E.T.

1983-03-01

When designing underground works, it is necessary to take account of not only the vertical stresses arising predictably from the weight of the rock overhead, but also horizontal stresses which may vary from one direction to another as a result of past tectonic action. This report discussed the techniques that have been used to measure such stresses. Few determinations have been made in Great Britain, so it has been necessary to augment what little is known by reference to fault systems, relying on correlations between the measured magnitude and direction of maximum horizontal stress with local tectonic history. This has enabled general conclusions to be reached for Great Britain. (author)

STRESSED STATE OF ROCKY SUBSOIL IN THE VICINITY OF A CIRCULAR SECTION HYDRAULIC ENGINEERING TUNNEL TAKING INTO ACCOUNT THE ANISOTROPY OF THE GROUND MEDIUM

Directory of Open Access Journals (Sweden)

D. T. Bautdinov

2016-01-01

Full Text Available Objectives. The aim of this study consists ina parametric analysis of the stress state of transversely isotropic rocky ground in the vicinity of a circular cross-sectional hydraulic tunnel taking into account the dead load of the subsoil medium under various relations of the elastic characteristics of the subsoil environment in orthogonal directions and at different angles of inclination of the plane of isotropy. Methods. A transversely isotropic medium model (a special case of an anisotropic medium is applied, in which the subsoil in one plane has the characteristics of an isotropic medium (isotropic plane but in a perpendicular direction – in contradistinction to the characteristics of an isotropic medium.The angle of isotropic planar inclination models the oblique bedding of subsoil layers. Results. The determination of tangential stresses on the contour generation allows the strength of the subsoil medium to be estimated at different depths of emplacement. The calculation of extensive hydraulic engineering tunnels, constructed in strong, transversely isotropic rocky ground, is reduced to a problem of plane strain elasticity theory for a transversely isotropic medium surrounding the tunnel construction. Since the solution of this problem cannot be achieved using analytical methods, the analysis of the stress state was carried out by finite element method using the ANSYS software complex. The type and size of the finite element appropriate for the calculation were pre-identified based on solutions to the task of verification. For the verificatory task, the Kirsch problem was adopted. Conclusion.When designing underground structures, it is necessary to determine the physical and mechanical properties of rocky soils in greater detail and to pay special attention to the elastic characteristics. The absence of tensile stresses in the upper section of development with some relations of the moduli of deformation and Poisson's ratios benefit the

Prospective Analysis of Risk Factors Related to Depression and Post Traumatic Stress Disorder in Deployed United States Navy Personnel

Science.gov (United States)

2011-03-28

post traumatic stress disorder ( PTSD ) and depression (MDD) than...United States Several epidemiological studies have been conducted on the prevalence of post traumatic stress disorder ( PTSD ) and major depression in...forms contain the same 4-item screener for post - traumatic stress disorder ( PTSD ). This screener was developed by the National Center for PTSD and

Altered mitochondrial function and oxidative stress in leukocytes of anorexia nervosa patients.

Science.gov (United States)

Victor, Victor M; Rovira-Llopis, Susana; Saiz-Alarcon, Vanessa; Sangüesa, Maria C; Rojo-Bofill, Luis; Bañuls, Celia; Falcón, Rosa; Castelló, Raquel; Rojo, Luis; Rocha, Milagros; Hernández-Mijares, Antonio

2014-01-01

Anorexia nervosa is a common illness among adolescents and is characterised by oxidative stress. The effects of anorexia on mitochondrial function and redox state in leukocytes from anorexic subjects were evaluated. A multi-centre, cross-sectional case-control study was performed. Our study population consisted of 20 anorexic patients and 20 age-matched controls, all of which were Caucasian women. Anthropometric and metabolic parameters were evaluated in the study population. To assess whether anorexia nervosa affects mitochondrial function and redox state in leukocytes of anorexic patients, we measured mitochondrial oxygen consumption, membrane potential, reactive oxygen species production, glutathione levels, mitochondrial mass, and complex I and III activity in polymorphonuclear cells. Mitochondrial function was impaired in the leukocytes of the anorexic patients. This was evident in a decrease in mitochondrial O2 consumption (Panorexia takes place at mitochondrial complex I. Future research concerning mitochondrial dysfunction and oxidative stress should aim to determine the physiological mechanism involved in this effect and the physiological impact of anorexia.

Residual stress in Ni-W electrodeposits

DEFF Research Database (Denmark)

Mizushima, Io; Tang, Peter Torben; Hansen, Hans Nørgaard

2006-01-01

In the present work, the residual stress in Ni–W layers electrodeposited from electrolytes based on NiSO4 and Na2WO4, is investigated. Citrate, glycine and triethanolamine were used as complexing agents, enabling complex formation between the nickel ion and tungstate. The results show that the type...... of complexing agent and the current efficiency have an influence on the residual stress. In all cases, an increase in tensile stress in the deposit with time after deposition was observed. Pulse plating could improve the stress level for the electrolyte containing equal amounts of citrate...

Creep and long-term strength of heat-resistant steels with different structures with the account taken of the type of stress deviator

International Nuclear Information System (INIS)

Giginyak, F.F.; Dragunov, Yu.G.; Mozharovskaya, T.N.; Titov, V.F.

1993-01-01

The results of the experimental investigations into creep and long-term strength of heat-resistant steels 15Kh2MFA and 15Kh2NMFA in the initial state and after heat-treatment simulating the metal irradiation embrittlement at the end of the product service date under static loading at the complex stress state and at high temperatures are presented. The experimentally substantiated equations of state describing creep and long-term stability of materials taking into account the type of the stress state are derived. (author)

Prestate of Stress and Fault Behavior During the 2016 Kumamoto Earthquake (M7.3)

Science.gov (United States)

Matsumoto, Satoshi; Yamashita, Yusuke; Nakamoto, Manami; Miyazaki, Masahiro; Sakai, Shinichi; Iio, Yoshihisa; Shimizu, Hiroshi; Goto, Kazuhiko; Okada, Tomomi; Ohzono, Mako; Terakawa, Toshiko; Kosuga, Masahiro; Yoshimi, Masayuki; Asano, Youichi

2018-01-01

Fault behavior during an earthquake is controlled by the state of stress on the fault. Complex coseismic fault slip on large earthquake faults has recently been observed by dense seismic networks, which complicates strong motion evaluations for potential faults. Here we show the three-dimensional prestress field related to the 2016 Kumamoto earthquake. The estimated stress field reveals a spatially variable state of stress that forced the fault to slip in a direction predicted by the "Wallace and Bott Hypothesis." The stress field also exposes the pre-condition of pore fluid pressure on the fault. Large coseismic slip occurred in the low-pressure part of the fault. However, areas with highly pressured fluid also showed large displacement, indicating that the seismic moment of the earthquake was magnified by fluid pressure. These prerupture data could contribute to improved seismic hazard evaluations.

Anisotropy effect of the clay soil masses on the stress-strain state of transport tunnels

Directory of Open Access Journals (Sweden)

Yushkov Boris Semenovich

2014-09-01

Full Text Available The article considers the kinds of clay soil mass anisotropy in the form of the spatial heterogeneity of properties of thawed and frozen soils, ambiguity of the frost heaving values and shrinkage in different directions. The questions of anisotropy of the clay soil properties at the positive temperatures are reported. The dependence of the heterogeneity of the physical and mechanical properties of frozen soils from the cryogenic texture, natural arrangement, different types of stratification and interbedding is considered. Indexes of the strength and strain anisotropy are noted. The accounting possibilities of the basic numerical indexes of heaving phenomena from the standpoint of anisotropy of the properties and processes inherent in the freezing through soil are analyzed by substitution in the heaving strain formula. The unevenness of thawed soil shrinkage in vertical and horizontal directions is noted during the freezing of the top layer. The unevenness of shrinkage in different directions is connected with kind of stress and cryogenic texture. Anisotropy of the frost heaving process is considered in the context of one-dimensional and non-one-dimensional problem depending on the amount of the freezing fronts and their direction. There is summarized the effect of anisotropy appearances on the stress-strain state of the transport tunnel. One can conclude that the resulting non-uniformity of heaving and shrinkage in conjunction with anisotropic properties of frozen soils, is a significant component in the complex of power factors determining the optimal design solution of a transport tunnel.

A simple state-contingent pricing rule for complex intertemporal externalities

Energy Technology Data Exchange (ETDEWEB)

McKitrick, Ross [Guelph Univ., ON (Canada). Dept. of Economics

2011-01-15

Some externalities, such as global warming, involve complex relationships between emissions and an environmental state variable, with effects over lags of uncertain length. Coming up with theoretically-motivated and practical policy options in such cases has proven difficult. Deterministic intertemporal general equilibrium models yield what appear to be feasible optimal price paths, but only by assuming away many key uncertainties, nor do they specify how the possibility of new information should affect the policy path. Bayesian models allow limited uncertainty and optimal learning based on observed effects of policy changes, but suggest a discouraging delay before optimal policy can be identified. A full insurance model suggests that risk aversion and 'fat-tailed' probabilities of catastrophe imply an implausibly (or at least impractically) large risk premium, implying that practical policy decisions depend so critically on uncertain parameters as to be unavoidably arbitrary. This paper proposes an entirely new approach based on the observation that the situation giving rise to a complex intertemporal externality also yields an observable state variable that contains information relevant to the identification of the optimal policy path. I derive a simple transformation by which the state variable can yield a good approximation to the optimal externality price. I outline assumptions sufficient to yield the transformation, and present numerical examples that illustrate its ability to follow linear and nonlinear first-best price paths. A specific application to greenhouse gases is proposed. (author)

A simple state-contingent pricing rule for complex intertemporal externalities

International Nuclear Information System (INIS)

McKitrick, Ross

2011-01-01

Some externalities, such as global warming, involve complex relationships between emissions and an environmental state variable, with effects over lags of uncertain length. Coming up with theoretically-motivated and practical policy options in such cases has proven difficult. Deterministic intertemporal general equilibrium models yield what appear to be feasible optimal price paths, but only by assuming away many key uncertainties, nor do they specify how the possibility of new information should affect the policy path. Bayesian models allow limited uncertainty and optimal learning based on observed effects of policy changes, but suggest a discouraging delay before optimal policy can be identified. A full insurance model suggests that risk aversion and 'fat-tailed' probabilities of catastrophe imply an implausibly (or at least impractically) large risk premium, implying that practical policy decisions depend so critically on uncertain parameters as to be unavoidably arbitrary. This paper proposes an entirely new approach based on the observation that the situation giving rise to a complex intertemporal externality also yields an observable state variable that contains information relevant to the identification of the optimal policy path. I derive a simple transformation by which the state variable can yield a good approximation to the optimal externality price. I outline assumptions sufficient to yield the transformation, and present numerical examples that illustrate its ability to follow linear and nonlinear first-best price paths. A specific application to greenhouse gases is proposed. (author)

Experimental Research of Reliability of Plant Stress State Detection by Laser-Induced Fluorescence Method

Directory of Open Access Journals (Sweden)

Yury Fedotov

2016-01-01

Full Text Available Experimental laboratory investigations of the laser-induced fluorescence spectra of watercress and lawn grass were conducted. The fluorescence spectra were excited by YAG:Nd laser emitting at 532 nm. It was established that the influence of stress caused by mechanical damage, overwatering, and soil pollution is manifested in changes of the spectra shapes. The mean values and confidence intervals for the ratio of two fluorescence maxima near 685 and 740 nm were estimated. It is presented that the fluorescence ratio could be considered a reliable characteristic of plant stress state.

Mindfulness meditation training alters stress-related amygdala resting state functional connectivity: a randomized controlled trial.

Science.gov (United States)

Taren, Adrienne A; Gianaros, Peter J; Greco, Carol M; Lindsay, Emily K; Fairgrieve, April; Brown, Kirk Warren; Rosen, Rhonda K; Ferris, Jennifer L; Julson, Erica; Marsland, Anna L; Bursley, James K; Ramsburg, Jared; Creswell, J David

2015-12-01

Recent studies indicate that mindfulness meditation training interventions reduce stress and improve stress-related health outcomes, but the neural pathways for these effects are unknown. The present research evaluates whether mindfulness meditation training alters resting state functional connectivity (rsFC) of the amygdala, a region known to coordinate stress processing and physiological stress responses. We show in an initial discovery study that higher perceived stress over the past month is associated with greater bilateral amygdala-subgenual anterior cingulate cortex (sgACC) rsFC in a sample of community adults (n = 130). A follow-up, single-blind randomized controlled trial shows that a 3-day intensive mindfulness meditation training intervention (relative to a well-matched 3-day relaxation training intervention without a mindfulness component) reduced right amygdala-sgACC rsFC in a sample of stressed unemployed community adults (n = 35). Although stress may increase amygdala-sgACC rsFC, brief training in mindfulness meditation could reverse these effects. This work provides an initial indication that mindfulness meditation training promotes functional neuroplastic changes, suggesting an amygdala-sgACC pathway for stress reduction effects. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Endoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic β-cells.

Directory of Open Access Journals (Sweden)

Irmgard Schuiki

Full Text Available Accumulation of unfolded, misfolded and aggregated proteins in the endoplasmic reticulum (ER causes ER stress. ER stress can result from physiological situations such as acute increases in secretory protein biosynthesis or pathological conditions that perturb ER homeostasis such as alterations in the ER redox state. Here we monitored ER redox together with transcriptional output of the Unfolded Protein Response (UPR in INS-1 insulinoma cells stably expressing eroGFP (ER-redox-sensor and mCherry protein driven by a GRP78 promoter (UPR-sensor. Live cell imaging, flow cytometry and biochemical characterization were used to examine these parameters in response to various conditions known to induce ER stress. As expected, treatment of the cells with the reducing agent dithiothreitol caused a decrease in the oxidation state of the ER accompanied by an increase in XBP-1 splicing. Unexpectedly however, other treatments including tunicamycin, thapsigargin, DL-homocysteine, elevated free fatty acids or high glucose had essentially no influence on the ER redox state, despite inducing ER stress. Comparable results were obtained with dispersed rat islet cells expressing eroGFP. Thus, unlike in yeast cells, ER stress in pancreatic β-cells is not associated with a more reducing ER environment.

Stress og aldring

DEFF Research Database (Denmark)

Jørgensen, Anders; Jørgensen, Martin Balslev; Poulsen, Henrik Enghusen

2012-01-01

Accumulating evidence supports the popular notion that psychological stress states may accelerate aging. Stress has been shown to influence cellular systems known to be involved in the aging process. Furthermore, stress is associated with an increased risk of various age-related medical disorders....... These effects are likely mediated by the secretion of stress hormones. In this short review we focus on biochemical and epidemiological evidence for a link between stress and aging.......Accumulating evidence supports the popular notion that psychological stress states may accelerate aging. Stress has been shown to influence cellular systems known to be involved in the aging process. Furthermore, stress is associated with an increased risk of various age-related medical disorders...

The influence of the anisotropic stress state on the intermediate strain properties of granular material

KAUST Repository

Goudarzy, M.; Kö nig, D.; Santamarina, Carlos; Schanz, T.

2017-01-01

This paper shows the effect of anisotropic stress state on intermediate strain properties of cylindrical samples containing spherical glass particles. Tests were carried out with the modified resonant column device available at Ruhr

Development and validation of the Acculturative Stress Scale for Chinese College Students in the United States (ASSCS).

Science.gov (United States)

Bai, Jieru

2016-04-01

Chinese students are the biggest ethnic group of international students in the United States. This study aims to develop a reliable and valid scale to accurately measure their acculturative stress. A 72-item pool was sent online to Chinese students and a five-factor scale of 32 items was generated by exploratory factor analysis. The five factors included language insufficiency, social isolation, perceived discrimination, academic pressure, and guilt toward family. The Acculturative Stress Scale for Chinese Students demonstrated high reliability and initial validity by predicting depression and life satisfaction. It was the first Chinese scale of acculturative stress developed and validated among a Chinese student sample in the United States. In the future, the scale can be used as a diagnostic tool by mental health professionals and a self-assessment tool by Chinese students. (c) 2016 APA, all rights reserved.

Stress factors for the deformation systems of zirconium under multiaxial stress

International Nuclear Information System (INIS)

Hobson, D.O.

1976-01-01

Calculation of the resolved shear stresses (rss) that act on various deformation systems in metals and, in particular, the determination of those systems subjected to the highest rss by a given set of multiaxial stresses is of importance in the study of texture development, yielding and plastic flow. This study examines the geometrical influences of any stress state on the deformation modes of zirconium. One slip mode and three twinning modes, comprising twenty-one deformation systems, are considered. Stress factors computed for these systems are shown on a coordinate system that allows specimen orientation, most highly stressed deformation system, and stress factor to be shown without ambiguity. The information in this report allows the determination of the rss that results from any multiaxial stress state; this information also allows the prediction of the deformation modes that might operate for any specimen orientation in that strss state

On the impact of multi-axial stress states on trailing edge bondlines in wind turbine rotor blades

Science.gov (United States)

Noever Castelos, Pablo; Balzani, Claudio

2016-09-01

For a reliable design of wind turbine systems all of their components have to be designed to withstand the loads appearing in the turbine's lifetime. When performed in an integral manner this is called systems engineering, and is exceptionally important for components that have an impact on the entire wind turbine system, such as the rotor blade. Bondlines are crucial subcomponents of rotor blades, but they are not much recognized in the wind energy research community. However, a bondline failure can lead to the loss of a rotor blade, and potentially of the entire turbine, and is extraordinarily relevant to be treated with strong emphasis when designing a wind turbine. Modern wind turbine rotor blades with lengths of 80 m and more offer a degree of flexibility that has never been seen in wind energy technology before. Large deflections result in high strains in the adhesive connections, especially at the trailing edge. The latest edition of the DNV GL guideline from end of 2015 demands a three-dimensional stress analysis of bondlines, whereas before an isolated shear stress proof was sufficient. In order to quantify the lack of safety from older certification guidelines this paper studies the influence of multi-axial stress states on the ultimate and fatigue load resistance of trailing edge adhesive bonds. For this purpose, detailed finite element simulations of the IWES IWT-7.5-164 reference wind turbine blades are performed. Different yield criteria are evaluated for the prediction of failure and lifetime. The results show that the multi-axial stress state is governed by span-wise normal stresses. Those are evidently not captured in isolated shear stress proofs, yielding non-conservative estimates of lifetime and ultimate load resistance. This finding highlights the importance to include a three-dimensional stress state in the failure analysis of adhesive bonds in modern wind turbine rotor blades, and the necessity to perform a three-dimensional characterization

Engineering Complex Embedded Systems with State Analysis and the Mission Data System

Science.gov (United States)

Ingham, Michel D.; Rasmussen, Robert D.; Bennett, Matthew B.; Moncada, Alex C.

2004-01-01

It has become clear that spacecraft system complexity is reaching a threshold where customary methods of control are no longer affordable or sufficiently reliable. At the heart of this problem are the conventional approaches to systems and software engineering based on subsystem-level functional decomposition, which fail to scale in the tangled web of interactions typically encountered in complex spacecraft designs. Furthermore, there is a fundamental gap between the requirements on software specified by systems engineers and the implementation of these requirements by software engineers. Software engineers must perform the translation of requirements into software code, hoping to accurately capture the systems engineer's understanding of the system behavior, which is not always explicitly specified. This gap opens up the possibility for misinterpretation of the systems engineer s intent, potentially leading to software errors. This problem is addressed by a systems engineering methodology called State Analysis, which provides a process for capturing system and software requirements in the form of explicit models. This paper describes how requirements for complex aerospace systems can be developed using State Analysis and how these requirements inform the design of the system software, using representative spacecraft examples.

Ab-initio atomic level stress and role of d-orbitals in CuZr, CuZn and CuY

Science.gov (United States)

Ojha, Madhusudan; Nicholson, Don M.; Egami, Takeshi

2015-03-01

Atomic level stress offers a new tool to characterize materials within the local approximation to density functional theory (DFT). Ab-initio atomic level stresses in B2 structures of CuZr, CuZn and CuY are calculated and results are explained on the basis of d-orbital contributions to Density of States (DOS). The overlap of d-orbital DOS plays an important role in the relative magnitude of atomic level stresses in these structures. The trends in atomic level stresses that we observed in these simple B2 structures are also seen in complex structures such as liquids, glasses and solid solutions. The stresses are however modified by the different coordination and relaxed separation distances in these complex structures. We used the Locally Self-Consistent Multiple Scattering (LSMS) code and Vienna Ab-initio Simulation Package (VASP) for ab-initio calculations.

Solid state photosensitive devices which employ isolated photosynthetic complexes

Science.gov (United States)

Peumans, Peter; Forrest, Stephen R.

2009-09-22

Solid state photosensitive devices including photovoltaic devices are provided which comprise a first electrode and a second electrode in superposed relation; and at least one isolated Light Harvesting Complex (LHC) between the electrodes. Preferred photosensitive devices comprise an electron transport layer formed of a first photoconductive organic semiconductor material, adjacent to the LHC, disposed between the first electrode and the LHC; and a hole transport layer formed of a second photoconductive organic semiconductor material, adjacent to the LHC, disposed between the second electrode and the LHC. Solid state photosensitive devices of the present invention may comprise at least one additional layer of photoconductive organic semiconductor material disposed between the first electrode and the electron transport layer; and at least one additional layer of photoconductive organic semiconductor material, disposed between the second electrode and the hole transport layer. Methods of generating photocurrent are provided which comprise exposing a photovoltaic device of the present invention to light. Electronic devices are provided which comprise a solid state photosensitive device of the present invention.

States of stress and slip partitioning in a continental scale strike-slip duplex: Tectonic and magmatic implications by means of finite element modeling

Science.gov (United States)

Iturrieta, Pablo Cristián; Hurtado, Daniel E.; Cembrano, José; Stanton-Yonge, Ashley

2017-09-01

Orogenic belts at oblique convergent subduction margins accommodate deformation in several trench-parallel domains, one of which is the magmatic arc, commonly regarded as taking up the margin-parallel, strike-slip component. However, the stress state and kinematics of volcanic arcs is more complex than usually recognized, involving first- and second-order faults with distinctive slip senses and mutual interaction. These are usually organized into regional scale strike-slip duplexes, associated with both long-term and short-term heterogeneous deformation and magmatic activity. This is the case of the 1100 km-long Liquiñe-Ofqui Fault System in the Southern Andes, made up of two overlapping margin-parallel master faults joined by several NE-striking second-order faults. We present a finite element model addressing the nature and spatial distribution of stress across and along the volcanic arc in the Southern Andes to understand slip partitioning and the connection between tectonics and magmatism, particularly during the interseismic phase of the subduction earthquake cycle. We correlate the dynamics of the strike-slip duplex with geological, seismic and magma transport evidence documented by previous work, showing consistency between the model and the inferred fault system behavior. Our results show that maximum principal stress orientations are heterogeneously distributed within the continental margin, ranging from 15° to 25° counter-clockwise (with respect to the convergence vector) in the master faults and 10-19° clockwise in the forearc and backarc domains. We calculate the stress tensor ellipticity, indicating simple shearing in the eastern master fault and transpressional stress in the western master fault. Subsidiary faults undergo transtensional-to-extensional stress states. The eastern master fault displays slip rates of 5 to 10 mm/yr, whereas the western and subsidiary faults show slips rates of 1 to 5 mm/yr. Our results endorse that favorably oriented

Study of nonequilibrium steady state of Fe(II) complex salt by means of synchrotron-radiation x-ray

CERN Document Server

Moritomo, Y

2003-01-01

In this article, we introduce our recent investigation at SPring-8/BL02B2 on the nonequilibrium steady state of photoexcited spin-crossover salts, which consists of Fe sup 2 sup + complexes and counter cations. The Fe sup 2 sup + complex takes two states; one is the low-spin state (S=0) and the other is the high-spin state (S=2). The photoexcitation can convert the low-spin site into the high-spin state, and hence, a finite the high-spin site is excited balancing with the thermal relaxation process. When the excitation power exceeds a critical value, we observe a dynamical phase transition into the high-spin condensed state.

Dynamic Stress Concentration at the Boundary of an Incision at the Plate Under the Action of Weak Shock Waves

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Mikulich Olena

2017-09-01

Full Text Available This paper proposes the novel technique for analysis of dynamic stress state of multi-connected infinite plates under the action of weak shock waves. For solution of the problem it uses the integral and discrete Fourier transforms. Calculation of transformed dynamic stresses at the incisions of plates is held using the boundary-integral equation method and the theory of complex variable functions. The numerical implementation of the developed algorithm is based on the method of mechanical quadratures and collocation technique. For calculation of originals of the dynamic stresses it uses modified discrete Fourier transform. The algorithm is effective in the analysis of the dynamic stress state of defective plates.

The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors.

Science.gov (United States)

Ikeda, Takako; Uno, Masaharu; Honjoh, Sakiko; Nishida, Eisuke

2017-08-09

The well-known link between longevity and the Sir2 histone deacetylase family suggests that histone deacetylation, a modification associated with repressed chromatin, is beneficial to longevity. However, the molecular links between histone acetylation and longevity remain unclear. Here, we report an unexpected finding that the MYST family histone acetyltransferase complex (MYS-1/TRR-1 complex) promotes rather than inhibits stress resistance and longevity in Caenorhabditis elegans Our results show that these beneficial effects are largely mediated through transcriptional up-regulation of the FOXO transcription factor DAF-16. MYS-1 and TRR-1 are recruited to the promoter regions of the daf-16 gene, where they play a role in histone acetylation, including H4K16 acetylation. Remarkably, we also find that the human MYST family Tip60/TRRAP complex promotes oxidative stress resistance by up-regulating the expression of FOXO transcription factors in human cells. Tip60 is recruited to the promoter regions of the foxo1 gene, where it increases H4K16 acetylation levels. Our results thus identify the evolutionarily conserved role of the MYST family acetyltransferase as a key epigenetic regulator of DAF-16/FOXO transcription factors. © 2017 The Authors.

STRESS-DEFORMED STATE OF A STRUT-FRAMED CRANE GIRDER

Directory of Open Access Journals (Sweden)

Kh. M. Muselemov

2017-01-01

Full Text Available Objectives. The aim of the present work is to study the influence of design parameters on the stress-deformed state of a sprengel crane girder; to compile the tables and corresponding graphs illustrating changes in internal force factors in the characteristic cross-sections of the system elements under consideration. The article describes the study of the stress-deformed state (SDS of a metal strut-framed crane girder.Methods. Numerical methods of analysis based on the use of the Green's function are used during solving this problem. A dimensionless parameter is introduced, depending on which the tables and graphs are constructed. According to the known algorithm, the calculations of internal force factors in the sections of the considered construction are performed.Results. Depending on the dimensionless parameter characterising the geometry and physical features of the system, tables of bending moments and transverse forces are compiled. According to these tables, the appropriate graphs are plotted in order to choose easily the optimal design parameters.Conclusion. The dependence of the moments and transverse forces on the dimensionless parameter k was found, the corresponding graphs were plotted and the metal costs for the girders were calculated. The minimum values of the moments and transverse forces are established to take place when the dimensionless parameter k values are close to zero. The most economical was a strut-framed crane girder having k = 0.0001. The most uneconomical had k = 0.05 and k =∞. Eventually, the sprengel girders were found to be more profitable as compared to conventional crane girders. In the examples considered in the article, the metal savings amounted up to 14%. The presented methodology allows the calculation and designing of strut-framed crane girders with two racks to be carried out. 

Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models.

Science.gov (United States)

Ishii, Takamasa; Yasuda, Kayo; Miyazawa, Masaki; Mitsushita, Junji; Johnson, Thomas E; Hartman, Phil S; Ishii, Naoaki

2016-04-01

Oxidative stress is associated with some forms of both male and female infertility. However, there is insufficient knowledge of the influence of oxidative stress on the maintenance of a viable pregnancy, including pregnancy complications and fetal development. There are a number of animal models for understanding age-dependent decrease of reproductive ability and diabetic embryopathy, especially abnormal spermatogenesis, oogenesis and embryogenesis with mitochondrial dysfunctions. Several important processes occur in mitochondria, including ATP synthesis, calcium ion storage, induction of apoptosis and production of reactive oxygen species (ROS). These events have different effects on the several aspects of reproductive function. Tet-mev-1 conditional transgenic mice, developed after studies with the mev-1 mutant of the nematode C. elegans, offer the ability to carefully regulate expression of doxycycline-induced mutated SDHC(V69E) levels and hence modulate endogenous oxidative stress. The mev-1 models have served to illuminate the effects of complex II deficiency-dependent mitochondrial ROS production, although interestingly they maintain normal mitochondrial and intracellular ATP levels. In this review, the reproductive dysfunctions are presented focusing on fertility potentials in each gamete, early embryogenesis, maternal conditions with placental function and neonatal development. Copyright © 2016. Published by Elsevier Ireland Ltd.

Symptoms of Psychological Distress and Post-Traumatic Stress Disorder in United States Air Force Drone Operators

Science.gov (United States)

2014-08-01

Disorder in United States Air Force “ Drone ” Operators 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...referred to as “ drones .” Participants were assessed for self-reported sources of occupational stress, levels of clinical distress using the Outcome...providers are discussed. 15. SUBJECT TERMS Stress, drone operator, PTSD, USAF 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT

Prediction of thermal and mechanical stress-strain responses of TMC's subjected to complex TMF histories

Science.gov (United States)

Johnson, W. S.; Mirdamadi, M.

1994-01-01

This paper presents an experimental and analytical evaluation of cross-plied laminates of Ti-15V-3Cr-3Al-3Sn (Ti-15-3) matrix reinforced with continuous silicon-carbide fibers (SCS-6) subjected to a complex TMF loading profile. Thermomechanical fatigue test techniques were developed to conduct a simulation of a generic hypersonic flight profile. A micromechanical analysis was used. The analysis predicts the stress-strain response of the laminate and of the constituents in each ply during thermal and mechanical cycling by using only constituent properties as input. The fiber was modeled as elastic with transverse orthotropic and temperature-dependent properties. The matrix was modeled using a thermoviscoplastic constitutive relation. The fiber transverse modulus was reduced in the analysis to simulate the fiber-matrix interface failures. Excellent correlation was found between measured and predicted laminate stress-strain response due to generic hypersonic flight profile when fiber debonding was modeled.

A comprehensive model of stress - The roles of experienced stress and neuroticism in explaining the stress-distress relationship

NARCIS (Netherlands)

De Jong, GM; van Sonderen, E; Emmelkamp, PMG

1999-01-01

Background: In this study, a complex theoretical model regarding the stress-distress relationship was evaluated. The various components in the model included experienced stress (daily hassles), psychological distress, neuroticism, problem-focused coping, avoidant coping, satisfaction with received

Highly photoluminescent europium tetraphenylimidodiphosphinate ternary complexes with heteroaromatic co-ligands. Solution and solid state studies

Energy Technology Data Exchange (ETDEWEB)

Pietraszkiewicz, Marek, E-mail: mpietraszkiewicz@ichf.edu.pl [Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw (Poland); Pietraszkiewicz, Oksana; Karpiuk, Jerzy; Majka, Alina [Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw (Poland); Dutkiewicz, Grzegorz; Borowiak, Teresa [Adam Mickiewicz University, Faculty of Chemistry, Department of Crystallography, Grunwaldzka 6, 60-780 Poznań (Poland); Kaczmarek, Anna M. [L3–Luminescent Lanthanide Lab, f-element coordination chemistry, Ghent University, Department of Inorganic and Physical Chemistry, Krijgslaan 281, Building S3, 9000 Gent (Belgium); Van Deun, Rik, E-mail: rik.vandeun@ugent.be [L3–Luminescent Lanthanide Lab, f-element coordination chemistry, Ghent University, Department of Inorganic and Physical Chemistry, Krijgslaan 281, Building S3, 9000 Gent (Belgium)

2016-02-15

Tetraphenylimidodiphosphinate (tpip) forms neutral 3:1 complexes with lanthanide ions. These complexes can accommodate one ancillary planar heterocyclic ligand to complement their coordination sphere of Eu{sup 3+} to coordination number 8. Several co-ligands were tested to form new complexes: 1,10-phenanthroline, bathophenanthroline, 2,4,6-tris(2-pyridyl)-1,3,5-triazine, dipyrido[3,2-f:2′,3′-h]quinoxaline and 2,2′:6′,2′′-terpyridine. The addition of heterocyclic N,N-bidentate co-ligands to the coordination sphere results in a dramatic (by a factor of 45–50) luminescence enhancement of the parent Eu(tpip){sub 3}. The solid-state measurements confirmed that the ancillary ligands strongly increased the photoluminescence quantum yield (PLQY) of the investigated complexes. - Highlights: • We have disovered highly photoluminescent ternary Eu(III) complexes. • They consist of Eu(III) tetraphenylimidodiphosphinate, and planar heterocyclic ligands. • The increase in photoluminescence quantum yields in solution is enhanced up to 50 times in solution. • The solid-state photoluminescence exceeds 80% at room temperature.

Highly photoluminescent europium tetraphenylimidodiphosphinate ternary complexes with heteroaromatic co-ligands. Solution and solid state studies

International Nuclear Information System (INIS)

Pietraszkiewicz, Marek; Pietraszkiewicz, Oksana; Karpiuk, Jerzy; Majka, Alina; Dutkiewicz, Grzegorz; Borowiak, Teresa; Kaczmarek, Anna M.; Van Deun, Rik

2016-01-01

Tetraphenylimidodiphosphinate (tpip) forms neutral 3:1 complexes with lanthanide ions. These complexes can accommodate one ancillary planar heterocyclic ligand to complement their coordination sphere of Eu 3+ to coordination number 8. Several co-ligands were tested to form new complexes: 1,10-phenanthroline, bathophenanthroline, 2,4,6-tris(2-pyridyl)-1,3,5-triazine, dipyrido[3,2-f:2′,3′-h]quinoxaline and 2,2′:6′,2′′-terpyridine. The addition of heterocyclic N,N-bidentate co-ligands to the coordination sphere results in a dramatic (by a factor of 45–50) luminescence enhancement of the parent Eu(tpip) 3 . The solid-state measurements confirmed that the ancillary ligands strongly increased the photoluminescence quantum yield (PLQY) of the investigated complexes. - Highlights: • We have disovered highly photoluminescent ternary Eu(III) complexes. • They consist of Eu(III) tetraphenylimidodiphosphinate, and planar heterocyclic ligands. • The increase in photoluminescence quantum yields in solution is enhanced up to 50 times in solution. • The solid-state photoluminescence exceeds 80% at room temperature.

Effects of single moor baths on physiological stress response and psychological state: a pilot study

Science.gov (United States)

Stier-Jarmer, M.; Frisch, D.; Oberhauser, C.; Immich, G.; Kirschneck, M.; Schuh, A.

2017-11-01

Moor mud applications in the form of packs and baths are widely used therapeutically as part of balneotherapy. They are commonly given as therapy for musculoskeletal disorders, with their thermo-physical effects being furthest studied. Moor baths are one of the key therapeutic elements in our recently developed and evaluated 3-week prevention program for subjects with high stress level and increased risk of developing a burnout syndrome. An embedded pilot study add-on to this core project was carried out to assess the relaxing effect of a single moor bath. During the prevention program, 78 participants received a total of seven moor applications, each consisting of a moor bath (42 °C, 20 min, given between 02:30 and 05:20 p.m.) followed by resting period (20 min). Before and after the first moor application in week 1, and the penultimate moor application in week 3, salivary cortisol was collected, blood pressure and heart rate were measured, and mood state (Multidimensional Mood State Questionnaire) was assessed. A Friedman test of differences among repeated measures was conducted. Post hoc analyses were performed using the Wilcoxon signed-rank test. A significant decrease in salivary cortisol concentration was seen between pre- and post-moor bath in week 1 ( Z = -3.355, p = 0.0008). A non-significant decrease was seen between pre- and post-moor bath in week 3. Mood state improved significantly after both moor baths. This pilot study has provided initial evidence on the stress-relieving effects of single moor baths, which can be a sensible and recommendable therapeutic element of multimodal stress-reducing prevention programs. The full potential of moor baths still needs to be validated. A randomized controlled trial should be conducted comparing this balneo-therapeutic approach against other types of stress reduction interventions.

Dark excited states of carotenoid in light harvesting complex probing with femtosecond stimulated Raman spectroscopy

Directory of Open Access Journals (Sweden)

Sakai S.

2013-03-01

Full Text Available Vibrational dynamics of dark excited states in carotenoids have been investigated using tunable Raman pump pulses. The S1 state has same vibrational dynamics in light-harvesting complex (LH1 and solution. The S* state in LH1 has similar vibrational modes with the triplet state of carotenoid. However, the so-called S* state in solution does not have the modes and is concluded to be different from the S* state in LH1.

Pressure and Stress Prediction in the Nankai Accretionary Prism: A Critical State Soil Mechanics Porosity-Based Approach

Science.gov (United States)

Flemings, Peter B.; Saffer, Demian M.

2018-02-01

We predict pressure and stress from porosity in the Nankai accretionary prism with a critical state soil model that describes porosity as a function of mean stress and maximum shear stress, and assumes Coulomb failure within the wedge and uniaxial burial beneath it. At Ocean Drilling Program Sites 1174 and 808, we find that pore pressure in the prism supports 70% to 90% of the overburden (λu = 0.7 to 0.9), for a range of assumed friction angles (5-30°). The prism pore pressure is equal to or greater than that in the underthrust sediments even though the porosity is lower within the prism. The high pore pressures lead to a mechanically weak wedge that supports low maximum shear stress, and this in turn requires very low basal traction to remain consistent with the observed narrowly tapered wedge geometry. We estimate the décollement friction coefficient (μb) to be 0.08-0.38 (ϕb' = 4.6°-21°). Our approach defines a pathway to predict pressure in a wide range of environments from readily observed quantities (e.g., porosity and seismic velocity). Pressure and stress control the form of the Earth's collisional continental margins and play a key role in its greatest earthquakes. However, heretofore, there has been no systematic approach to relate material state (e.g., porosity), pore pressure, and stress in these systems.

Calculation of a steam generating tube stressed state under temperature oscillations in burnout zone

International Nuclear Information System (INIS)

Vorob'ev, V.A.; Loshchinin, V.M.; Remizov, O.V.

1982-01-01

The technique for evaluating the steam generating tube stressed state under the wall temperature oscillations in the burnout zone is described. The technique is based on analytical solutions for transfer functions connecting the amplitude of surface temperature oscillation with the amplitude and frequency of heat transfer coefficient oscillation and amplitude of thermoelastic stress oscillation with that of temperature oscillation. The results of calculations according to considered technique are compared with that of the problem numerical solution. The conclusion is made that the technique under consideration may be applied for evaluation of steam generator evaporating tube lifetime [ru

Zeaxanthin binds to light-harvesting complex stress-related protein to enhance nonphotochemical quenching in Physcomitrella patens.

Science.gov (United States)

Pinnola, Alberta; Dall'Osto, Luca; Gerotto, Caterina; Morosinotto, Tomas; Bassi, Roberto; Alboresi, Alessandro

2013-09-01

Nonphotochemical quenching (NPQ) dissipates excess energy to protect the photosynthetic apparatus from excess light. The moss Physcomitrella patens exhibits strong NPQ by both algal-type light-harvesting complex stress-related (LHCSR)-dependent and plant-type S subunit of Photosystem II (PSBS)-dependent mechanisms. In this work, we studied the dependence of NPQ reactions on zeaxanthin, which is synthesized under light stress by violaxanthin deepoxidase (VDE) from preexisting violaxanthin. We produced vde knockout (KO) plants and showed they underwent a dramatic reduction in thermal dissipation ability and enhanced photoinhibition in excess light conditions. Multiple mutants (vde lhcsr KO and vde psbs KO) showed that zeaxanthin had a major influence on LHCSR-dependent NPQ, in contrast with previous reports in Chlamydomonas reinhardtii. The PSBS-dependent component of quenching was less dependent on zeaxanthin, despite the near-complete violaxanthin to zeaxanthin exchange in LHC proteins. Consistent with this, we provide biochemical evidence that native LHCSR protein binds zeaxanthin upon excess light stress. These findings suggest that zeaxanthin played an important role in the adaptation of modern plants to the enhanced levels of oxygen and excess light intensity of land environments.

Complex Regional Pain Syndrome type I of the upper limb - treatment based on Stress Loading Program: a case study

Directory of Open Access Journals (Sweden)

Aline Sarturi Ponte

2015-03-01

Full Text Available The daily life of an individual suffering from Complex Regional Pain Syndrome type I (CPRS I becomes limited, because this syndrome causes signs and symptoms located in the affected limb, and may occur in other parts. From this premise, this study aims to present the contributions of Occupational Therapy and the Rehabilitation Stress Loading Program for a subject with CRPS I in the upper limb, attended by the Group of Pain from the University Hospital of Santa Maria (HUSM, Rio Grande do Sul state. This research is characterized as a case study, experimental, which deals with pre and post occupational therapy intervention. The instruments used for data collection were the protocols of Disabilities of the Arm, Shoulder and Hand (DASH, the International Classification of Disability, Functioning and Health (ICF, the Canadian Occupational Performance Measure (COPM, the Visual Analogue Scale, and goniometry (EVA. After assessment, the subject was exposed to the treatment of compressive active resistive exercises; after this treatment was completed, the subject was reassessed. It was observed that the treatment applied has contributed to the reduction of the pain and to the improvement in the Range of Motion (ROM of the subject. The use of the stress protocol and active compression contributed significantly to the reduction of pain, ADM gain and occupational performance improvement.

Analysis of internal stress and anelasticity in the shock-compressed state from unloading wave data

International Nuclear Information System (INIS)

Johnson, J.N.; Lomdahl, P.S.; Wills, J.M.

1991-01-01

This paper reports on time resolved shock-wave measurements have often been used to infer microstructural behavior in crystalline solids. The authors apply this approach to an interpretation of the release-wave response of an aluminum alloy (6061-T6) as it is dynamically unloaded from a shock-compressed state of 20.7 GPa. The anelastic behavior in the initial portion of the unloading wave is attributed to the accumulation of internal stresses created by the shock process. Specific internal-stress models which are investigated are the double pile-up, the single pile-up, and single dislocation loops between pinning points. It is found that the essential characteristics of double and single pile-ups can be represented by a single dislocation between two pinned dislocations of like sing. Calculations of anelastic wave speeds at constant unloading strain rate are then compared with experimental data. The results suggest that the residual internal stress is due to pinned loops of density 10 15 M - 2 , and the viscous drag coefficient in the shock-compressed state is on the order of 10 - 7 MPa s (approximately two orders of magnitude greater than expected under ambient conditions)

Development of Kossel micro-diffraction for strain and stress analysis at the micrometer scale: applications to crystalline materials

International Nuclear Information System (INIS)

Bouscaud, D.

2012-01-01

X-ray diffraction is a non-destructive method frequently used in materials science to analyse the stress state at a macroscopic scale. Due to the growing complexity of new materials and their applications, it is necessary to know the strain and stress state at a lower scale. Thus, a Kossel micro-diffraction experimental set-up was developed inside a scanning electron microscope. It allows to obtain the crystallographic orientation as well as the strains and stresses within a volume of a few cubic micrometers. Some experiments were also performed using a synchrotron radiation. An experimental procedure was developed to optimize the acquisition of Kossel line patterns and their post-processing. The stress calculation from Kossel patterns was validated by comparing the stress state of single crystals during in situ mechanical loading, obtained by Kossel micro-diffraction and with classical diffraction methods. Then Kossel micro-diffraction was applied to polycrystalline samples by gradually decreasing the grain size. Intergranular stress heterogeneities were for example measured in an interstitial-free steel. Experiments were finally carried out in thin layer samples representative of microelectronic components. (author)

Laboratory results of stress corrosion cracking of steam generator tubes in a complex environment - An update

Energy Technology Data Exchange (ETDEWEB)

Horner, Olivier; Pavageau, Ellen-Mary; Vaillant, Francois [EDF R and D, Materials and Mechanics of Components Department, 77818 Moret-sur-Loing (France); Bouvier, Odile de [EDF Nuclear Engineering Division, Centre d' Expertise et d' Inspection dans les Domaines de la Realisation et de l' Exploitation, 93206 Saint Denis (France)

2004-07-01

Stress corrosion cracking occurs in the flow-restricted areas on the secondary side of steam generator tubes of Pressured Water Reactors (PWR), where water pollutants are likely to concentrate. Chemical analyses carried out during the shutdowns gave some insight into the chemical composition of these areas, which has evolved during these last years (i.e. less sodium as pollutants). It has been modeled in laboratory by tests in two different typical environments: the sodium hydroxide and the sulfate environments. These models satisfactorily describe the secondary side corrosion of steam generator tubes for old plant units. Furthermore, a third typical environment - the complex environment - which corresponds to an All Volatile Treatment (AVT) environment containing alumina, silica, phosphate and acetic acid has been recently studied. This particular environment satisfactorily reproduces the composition of the deposits observed on the surface of the steam generator tubes as well as the degradation of the tubes. A review of the recent laboratory results obtained by considering the complex environment are presented here. Several tests have been carried out in order to study initiation and propagation of secondary side corrosion cracking for some selected materials in such an environment. 600 Thermally Treated (TT) alloy reveals to be less sensitive to secondary side corrosion cracking than 600 Mill Annealed (MA) alloy. Finally, the influence of some related factors like stress, temperature and environmental factors are discussed. (authors)

Laboratory results of stress corrosion cracking of steam generator tubes in a complex environment - An update

International Nuclear Information System (INIS)

Horner, Olivier; Pavageau, Ellen-Mary; Vaillant, Francois; Bouvier, Odile de

2004-01-01

Stress corrosion cracking occurs in the flow-restricted areas on the secondary side of steam generator tubes of Pressured Water Reactors (PWR), where water pollutants are likely to concentrate. Chemical analyses carried out during the shutdowns gave some insight into the chemical composition of these areas, which has evolved during these last years (i.e. less sodium as pollutants). It has been modeled in laboratory by tests in two different typical environments: the sodium hydroxide and the sulfate environments. These models satisfactorily describe the secondary side corrosion of steam generator tubes for old plant units. Furthermore, a third typical environment - the complex environment - which corresponds to an All Volatile Treatment (AVT) environment containing alumina, silica, phosphate and acetic acid has been recently studied. This particular environment satisfactorily reproduces the composition of the deposits observed on the surface of the steam generator tubes as well as the degradation of the tubes. A review of the recent laboratory results obtained by considering the complex environment are presented here. Several tests have been carried out in order to study initiation and propagation of secondary side corrosion cracking for some selected materials in such an environment. 600 Thermally Treated (TT) alloy reveals to be less sensitive to secondary side corrosion cracking than 600 Mill Annealed (MA) alloy. Finally, the influence of some related factors like stress, temperature and environmental factors are discussed. (authors)

Mechanical Characterization of Thermomechanical Matrix Residual Stresses Incurred During MMC Processing

Science.gov (United States)

Castelli, Michael G.

1998-01-01

In recent years, much effort has been spent examining the residual stress-strain states of advanced composites. Such examinations are motivated by a number of significant concerns that affect composite development, processing, and analysis. The room-temperature residual stress states incurred in many advanced composite systems are often quite large and can introduce damage even prior to the first external mechanical loading of the material. These stresses, which are induced during the cooldown following high-temperature consolidation, result from the coefficient of thermal expansion mismatch between the fiber and matrix. Experimental techniques commonly used to evaluate composite internal residual stress states are non-mechanical in nature and generally include forms of x-ray and neutron diffraction. Such approaches are usually complex, involving a number of assumptions and limitations associated with a wide range of issues, including the depth of penetration, the volume of material being assessed, and erroneous effects associated with oriented grains. Furthermore, and more important to the present research, these techniques can assess only "single time" stress in the composite. That is, little, if any, information is obtained that addresses the time-dependent point at which internal stresses begin to accumulate, the manner in which the accumulation occurs, and the presiding relationships between thermoelastic, thermoplastic, and thermoviscous behaviors. To address these critical issues, researchers at the NASA Lewis Research Center developed and implemented an innovative mechanical test technique to examine in real time, the time-dependent thermomechanical stress behavior of a matrix alloy as it went through a consolidation cycle.

Density of phonon states in the light-harvesting complex II of green plants

CERN Document Server

Pieper, J K; Irrgang, K D; Renger, G

2002-01-01

In photosynthetic antenna complexes, the coupling of electronic transitions to low-frequency vibrations of the protein matrix (phonons) plays an essential role in light absorption and ultra-fast excitation energy transfer (EET). The model calculations presented here indicate that inelastic neutron scattering experiments provide invaluable information on the phonon density of states for light-harvesting complex II, which may permit a consistent interpretation of contradictory results from high-resolution optical spectroscopy. (orig.)

Dynamic Simulation of the 2011 M9.0 Tohoku Earthquake with Geometric Complexity on a Rate- and State-dependent Subduction Plane

Science.gov (United States)

Luo, B.; Duan, B.

2015-12-01

The Mw 9.0 Tohoku megathrust earthquake on 11 March 2011 is a great surprise to the scientific community due to its unexpected occurrence on the subduction zone of Japan Trench where earthquakes of magnitude ~7 to 8 are expected based on historical records. Slip distribution and kinematic slip history inverted from seismic data, GPS and tsunami recordings reveal two major aspects of this big event: a strong asperity near the hypocenter and large slip near the trench. To investigate physical conditions of these two aspects, we perform dynamic rupture simulations on a shallow-dipping rate- and state-dependent subduction plane with topographic relief. Although existence of a subducted seamount just up-dip of the hypocenter is still an open question, high Vp anomalies [Zhao et al., 2011] and low Vp/Vs anomalies [Yamamoto et al., 2014] there strongly suggest some kind of topographic relief exists there. We explicitly incorporate a subducted seamount on the subduction surface into our models. Our preliminary results show that the subducted seamount play a significant role in dynamic rupture propagation due to the alteration of the stress state around it. We find that a subducted seamount can act as a strong barrier to many earthquakes, but its ultimate failure after some earthquake cycles results in giant earthquakes. Its failure gives rise to large stress drop, resulting in a strong asperity in slip distribution as revealed in kinematic inversions. Our preliminary results also suggest that the rate- and state- friction law plays an important role in rupture propagation of geometrically complex faults. Although rate-strengthening behavior near the trench impedes rupture propagation, an energetic rupture can break such a barrier and manage to reach the trench, resulting in significant uplift at seafloor and hence devastating tsunami to human society.

IMPROVING THE EFFICIENCY OF THE STATE FINANCIAL CONTROL IN THE SPHERE OF HIGH-TECH MILITARY-INDUSTRIAL COMPLEX

Directory of Open Access Journals (Sweden)

Anzhela Zakhitovna Namitulina

2016-01-01

Full Text Available The presented research topic is particularly relevant due to the high value and the need to strengthen fi nancial control for the development of the military-industrial complex (MIC, to ensure the country's economic security, preservation and development of scientifi c and technical potential. The urgency of acquiring those aspects of economic relations which are connected with the supply the export of high-tech military products in a limited budget funding State should have levers of infl uence on the functioning of the military-industrial complex, the ability to pursue an independent foreign military-technical policy. In the new economic conditions, it became necessary to address the problems of fi nancial security of the defense-industrial complex, in order to strengthen the independence and security of Russia, as well as the need to give priority nature of the measures of state control in the economy related to the implementation of the defense order, ie, in the sphere of military-industrial complex. At the present stage of economic development of Russia, the rate of growth of the national economy largely depends on what the situation is in the military-industrial complex (MIC. This is due to the fact that the defense industry is the most high-quality, high-tech economy. It concentrated the largest part of the Russian potential, the best staff of scientists and experts. Products and DIC technology widely used in other industries. The modern military-industrial complex produces a signifi cant part of civil production. DIC integration with civilian industries – it is also a technological basis for solving the basic problems currently facing the Russian economy, and, above all, the basis of the formation of a new technological basis for the development of high technology and competitive products, which determines the pace of scientifi c and technological progress and the growth of the national economy. Objectives. The aim of the paper is the

Relationships among Career and Life Stress, Negative Career thoughts, and Career Decision State: A Cognitive Information Processing Perspective

Science.gov (United States)

Bullock-Yowell, Emily; Peterson, Gary W.; Reardon, Robert C.; Leierer, Stephen J.; Reed, Corey A.

2011-01-01

According to cognitive information processing theory, career thoughts mediate the relationship between career and life stress and the ensuing career decision state. Using a sample of 232 college students and structural equation modeling, this study found that an increase in career and life stress was associated with an increase in negative career…

Effects of location, thermal stress and residual stress on corner cracks in nozzles with cladding

International Nuclear Information System (INIS)

McLean, J.L.; Cohen, L.M.; Besuner, P.M.

1979-01-01

The stress intensity factors (K 1 ) for corner cracks in a boiling water reactor feedwater nozzle with stainless steel cladding are obtained for loading by internal pressure and a fluid quench in the nozzle. Conditions both with and without residual stress in the component are considered. The residual stress is simulated by means of a reference temperature change. The stress distribution for the uncracked structure is obtained from a three-dimensional finite element model. A three-dimensional influence function (IF) method, in conjunction with the boundary-integral equation method for structural analysis, is employed to compute K 1 values from the uncracked stress distribution. For each type of loading K 1 values are given for cracks at 15 nozzle locations and for 6 crack depths. Reasonable agreement is noted between calculated and previously published pressure-induced K 1 values. Comparisons are made to determine the effect on K 1 of crack location, thermal stress and residual stress, as compared with pressure stress. For the thermal transient it is shown that K 1 for small crack depths is maximised early in the transient, while K 1 for large cracks is maximised later under steady state conditions. Computation should, therefore, be made for several transient time points and the maximum K 1 for a given crack depth should be used for design analysis. It is concluded that the effects on K 1 of location, thermal stresses and residual stresses are significant and generally too complex to evaluate without advanced numerical procedures. The utilised combination of finite element analysis of the uncracked structure and three-dimensional influence function analysis of the cracked structure is demonstrated and endorsed. (author)

Electroencephalogram, cognitive state, psychological disorders, clinical symptom, and oxidative stress in horticulture farmers exposed to organophosphate pesticides.

Science.gov (United States)

Bayrami, Mansour; Hashemi, Touraj; Malekirad, Ali Akbar; Ashayeri, Hassan; Faraji, Fardin; Abdollahi, Mohammad

2012-02-01

The aim of this paper was to study the toxicity of organophosphate (OP) pesticides in exposed farmers for electroencephalography, cognitive state, psychological disorders, clinical symptom, oxidative stress, acetylcholinesterase, and DNA damage. A comparative cross-sectional analysis was carried out in 40 horticulture farmers who were exposed to OPs in comparison to a control group containing 40 healthy subjects with the same age and sex and education level. Lipid peroxidation (LPO), superoxide dismutase (SOD), catalase, glutathione peroxidase, DNA damage, total antioxidant capacity (TAC), total thiol molecules, and acetylcholinesterase (AChE) activity were measured in the blood of subjects. Clinical examination and complete blood test were undertaken in order to record any abnormal sign or symptoms. Cognitive function, psychological symptoms, and psychological distress were examined and recorded. Comparing with controls, the farmers showed higher blood levels of SOD and LPO while their TAC decreased. Farmers showed clinical symptoms such as eczema, breathing muscle weakness, nausea, and saliva secretion. Regarding cognitive function, the orientation, registration, attention and calculation, recall, and language were not significantly different in farmers and controls. Among examinations for psychological distress, only labeled somatization was significantly higher in farmers. The present findings indicate that oxidative stress and inhibition of AChE can be seen in chronically OP-exposed people but incidence of neuropsychological disorders seems a complex multivariate phenomenon that might be seen in long-term high-dose exposure situations. Use of supplementary antioxidants would be useful in the treatment of farmers.

THE STRESS-STRAIN STATE OF ELASTIC HALF-SPACE FROM RUNNING LINEAR LOAD ACTING ON THE LIMITED AND UNLIMITED EXTENT OVER ITS SURFACE

Directory of Open Access Journals (Sweden)

I. K. Badalakha

2009-02-01

Full Text Available The article shows the result of solving the problem of stress-strain state of an elastic half-space because of the load action that uniformly distributed over the line, with the use of untraditional linear dependence of deformations on stressed state that is different from the generalized Hooke’s law.

Mathematical Modeling in Systems for Operational Evaluation of the Stress-Strain State of the Arch-Gravity Dam at the Sayano-Shushenskaya Hydroelectric Power Plant

Energy Technology Data Exchange (ETDEWEB)

Bellendir, E. N.; Gordon, L. A., E-mail: lev-gordon@mail.ru; Khrapkov, A. A.; Skvortsova, A. E., E-mail: SkvortsovaAE@vniig.ru [B. E. Vedeneev All-Russia Research Institute of Hydraulic Engineering (VNIIG) (Russian Federation)

2017-01-15

Current studies of the stress-strain state of the dam at the Sayano-Shushenskaya Hydroelectric Power Plant at VNIIG based on mathematical modeling including full scale and experimental data are described. Applications and programs intended for automatic operational evaluation of the stress-strain state of the dam for optimizing control of the upper race level in the course of the annual filling-drawdown cycle and during seismic events are examined. Improvements in systems for monitoring the stress-strain state of concrete dams are proposed.

Complex Analysis of Financial State and Performance of Construction Enterprises

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Algirdas Krivka

2015-12-01

Full Text Available The paper analyses the financial state and performance of large constructions enterprises by applying financial indicators. As there is no one single decisive financial indicator enabling to objectively assess enterprise performance, the multi-criteria decision making (MCDM methods are applied with four groups of financial ratios (profitability, liquidity, solvency and asset turnover acting as evaluation criteria, while the alternatives assessed are two enterprises compared throughout the reference period of three years, also with the average indicator values of the whole construction sector. The weights of the criteria have been estimated by involving competent experts with chi-square test employed to check the degree of agreement of expert estimates. The research methodology contributes to the issue of complex evaluation of enterprise financial state and performance, while the result of the multi-criteria assessment – the ranking of enterprises and sector average with respect to financial state and performance – could be considered worth attention from business owners, potential investors, customers or other possible stakeholders.

Fatigue Behavior under Multiaxial Stress States Including Notch Effects and Variable Amplitude Loading

Science.gov (United States)

Gates, Nicholas R.

The central objective of the research performed in this study was to be able to better understand and predict fatigue crack initiation and growth from stress concentrations subjected to complex service loading histories. As such, major areas of focus were related to the understanding and modeling of material deformation behavior, fatigue damage quantification, notch effects, cycle counting, damage accumulation, and crack growth behavior under multiaxial nominal loading conditions. To support the analytical work, a wide variety of deformation and fatigue tests were also performed using tubular and plate specimens made from 2024-T3 aluminum alloy, with and without the inclusion of a circular through-thickness hole. However, the analysis procedures implemented were meant to be general in nature, and applicable to a wide variety of materials and component geometries. As a result, experimental data from literature were also used, when appropriate, to supplement the findings of various analyses. Popular approaches currently used for multiaxial fatigue life analysis are based on the idea of computing an equivalent stress/strain quantity through the extension of static yield criteria. This equivalent stress/strain is then considered to be equal, in terms of fatigue damage, to a uniaxial loading of the same magnitude. However, it has often been shown, and was shown again in this study, that although equivalent stress- and strain-based analysis approaches may work well in certain situations, they lack a general robustness and offer little room for improvement. More advanced analysis techniques, on the other hand, provide an opportunity to more accurately account for various aspects of the fatigue failure process under both constant and variable amplitude loading conditions. As a result, such techniques were of primary interest in the investigations performed. By implementing more advanced life prediction methodologies, both the overall accuracy and the correlation of fatigue

Stress state and movement potential of the Kar-e-Bas fault zone, Fars, Iran

Science.gov (United States)

Sarkarinejad, Khalil; Zafarmand, Bahareh

2017-08-01

The Kar-e-Bas or Mengharak basement-inverted fault is comprised of six segments in the Zagros foreland folded belt of Iran. In the Fars region, this fault zone associated with the Kazerun, Sabz-Pushan and Sarvestan faults serves as a lateral transfer zone that accommodates the change in shortening direction from the western central to the eastern Zagros. This study evaluates the recent tectonic stress regime of the Kar-e-Bas fault zone based on inversion of earthquake focal mechanism data, and quantifies the fault movement potential of this zone based on the relationship between fault geometric characteristics and recent tectonic stress regimes. The trend and plunge of σ 1 and σ 3 are S25°W/04°-N31°E/05° and S65°E/04°-N60°W/10°, respectively, with a stress ratio of Φ = 0.83. These results are consistent with the collision direction of the Afro-Arabian continent and the Iranian microcontinent. The near horizontal plunge of maximum and minimum principle stresses and the value of stress ratio Φ indicate that the state of stress is nearly strike-slip dominated with little relative difference between the value of two principal stresses, σ 1 and σ 2. The obliquity of the maximum compressional stress into the fault trend reveals a typical stress partitioning of thrust and strike-slip motion in the Kar-e-Bas fault zone. Analysis of the movement potential of this fault zone shows that its northern segment has a higher potential of fault activity (0.99). The negligible difference between the fault-plane dips of the segments indicates that their strike is a controlling factor in the changes in movement potential.

Stresses in Circular Plates with Rigid Elements

Science.gov (United States)

Velikanov, N. L.; Koryagin, S. I.; Sharkov, O. V.

2018-05-01

Calculations of residual stress fields are carried out by numerical and static methods, using the flat cross-section hypothesis. The failure of metal when exposed to residual stresses is, in most cases, brittle. The presence in the engineering structures of rigid elements often leads to the crack initiation and structure failure. This is due to the fact that rigid elements under the influence of external stresses are stress concentrators. In addition, if these elements are fixed by welding, the residual welding stresses can lead to an increase in stress concentration and, ultimately, to failure. The development of design schemes for such structures is a very urgent task for complex technical systems. To determine the stresses in a circular plate with a welded circular rigid insert under the influence of an external load, one can use the solution of the plane stress problem for annular plates in polar coordinates. The polar coordinates of the points are the polar radius and the polar angle, and the stress state is determined by normal radial stresses, tangential and shearing stresses. The use of the above mentioned design schemes, formulas, will allow more accurate determination of residual stresses in annular welded structures. This will help to establish the most likely directions of failure and take measures at the stages of designing, manufacturing and repairing engineering structures to prevent these failures. However, it must be taken into account that the external load, the presence of insulation can lead to a change in the residual stress field.

Rupture Complexity Promoted by Damaged Fault Zones in Earthquake Cycle Models

Science.gov (United States)

Idini, B.; Ampuero, J. P.

2017-12-01

Pulse-like ruptures tend to be more sensitive to stress heterogeneity than crack-like ones. For instance, a stress-barrier can more easily stop the propagation of a pulse than that of a crack. While crack-like ruptures tend to homogenize the stress field within their rupture area, pulse-like ruptures develop heterogeneous stress fields. This feature of pulse-like ruptures can potentially lead to complex seismicity with a wide range of magnitudes akin to the Gutenberg-Richter law. Previous models required a friction law with severe velocity-weakening to develop pulses and complex seismicity. Recent dynamic rupture simulations show that the presence of a damaged zone around a fault can induce pulse-like rupture, even under a simple slip-weakening friction law, although the mechanism depends strongly on initial stress conditions. Here we aim at testing if fault zone damage is a sufficient ingredient to generate complex seismicity. In particular, we investigate the effects of damaged fault zones on the emergence and sustainability of pulse-like ruptures throughout multiple earthquake cycles, regardless of initial conditions. We consider a fault bisecting a homogeneous low-rigidity layer (the damaged zone) embedded in an intact medium. We conduct a series of earthquake cycle simulations to investigate the effects of two fault zone properties: damage level D and thickness H. The simulations are based on classical rate-and-state friction, the quasi-dynamic approximation and the software QDYN (https://github.com/ydluo/qdyn). Selected fully-dynamic simulations are also performed with a spectral element method. Our numerical results show the development of complex rupture patterns in some damaged fault configurations, including events of different sizes, as well as pulse-like, multi-pulse and hybrid pulse-crack ruptures. We further apply elasto-static theory to assess how D and H affect ruptures with constant stress drop, in particular the flatness of their slip profile

Recovery in dc and rf performance of off-state step-stressed AlGaN/GaN high electron mobility transistors with thermal annealing

International Nuclear Information System (INIS)

Kim, Byung-Jae; Hwang, Ya-Hsi; Ahn, Shihyun; Zhu, Weidi; Dong, Chen; Lu, Liu; Ren, Fan; Holzworth, M. R.; Jones, Kevin S.; Pearton, Stephen J.; Smith, David J.; Kim, Jihyun; Zhang, Ming-Lan

2015-01-01

The recovery effects of thermal annealing on dc and rf performance of off-state step-stressed AlGaN/GaN high electron mobility transistors were investigated. After stress, reverse gate leakage current and sub-threshold swing increased and drain current on-off ratio decreased. However, these degradations were completely recovered after thermal annealing at 450 °C for 10 mins for devices stressed either once or twice. The trap densities, which were estimated by temperature-dependent drain-current sub-threshold swing measurements, increased after off-state step-stress and were reduced after subsequent thermal annealing. In addition, the small signal rf characteristics of stressed devices were completely recovered after thermal annealing

Mediator, SWI/SNF and SAGA complexes regulate Yap8-dependent transcriptional activation of ACR2 in response to arsenate.

Science.gov (United States)

Menezes, Regina Andrade; Pimentel, Catarina; Silva, Ana Rita Courelas; Amaral, Catarina; Merhej, Jawad; Devaux, Frédéric; Rodrigues-Pousada, Claudina

2017-04-01

Response to arsenic stress in Saccharomyces cerevisiae is orchestrated by the regulatory protein Yap8, which mediates transcriptional activation of ACR2 and ACR3. This study contributes to the state of art knowledge of the molecular mechanisms underlying yeast stress response to arsenate as it provides the genetic and biochemical evidences that Yap8, through cysteine residues 132, 137, and 274, is the sensor of presence of arsenate in the cytosol. Moreover, it is here reported for the first time the essential role of the Mediator complex in the transcriptional activation of ACR2 by Yap8. Based on our data, we propose an order-of-function map to recapitulate the sequence of events taking place in cells injured with arsenate. Modification of the sulfhydryl state of these cysteines converts Yap8 in its activated form, triggering the recruitment of the Mediator complex to the ACR2/ACR3 promoter, through the interaction with the tail subunit Med2. The Mediator complex then transfers the regulatory signals conveyed by Yap8 to the core transcriptional machinery, which culminates with TBP occupancy, ACR2 upregulation and cell adaptation to arsenate stress. Additional co-factors are required for the transcriptional activation of ACR2 by Yap8, particularly the nucleosome remodeling activity of SWI/SNF and SAGA complexes. Copyright © 2017. Published by Elsevier B.V.

Oxidative Stress in Complex Regional Pain Syndrome (CRPS): No Systemically Elevated Levels of Malondialdehyde, F2-Isoprostanes and 8OHdG in a Selected Sample of Patients

NARCIS (Netherlands)

Fischer, S.G.L.; Perez, R.S.G.M.; Nouta, J.; Zuurmond, W.W.A.; Scheffer, P.G.

2013-01-01

Exaggerated inflammation and oxidative stress are involved in the pathogenesis of Complex Regional Pain Syndrome (CRPS). However, studies assessing markers for oxidative stress in CRPS patients are limited. In this study, markers for lipid peroxidation (malondialdehyde and F2-isoprostanes) and DNA

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice.

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Naïg Gueguen

Full Text Available Resveratrol is often described as a promising therapeutic molecule for numerous diseases, especially in metabolic and neurodegenerative disorders. While the mechanism of action is still debated, an increasing literature reports that resveratrol regulates the mitochondrial respiratory chain function. In a recent study we have identified mitochondrial complex I as a direct target of this molecule. Nevertheless, the mechanisms and consequences of such an interaction still require further investigation. In this study, we identified in silico by docking study a binding site for resveratrol at the nucleotide pocket of complex I. In vitro, using solubilized complex I, we demonstrated a competition between NAD+ and resveratrol. At low doses (<5μM, resveratrol stimulated complex I activity, whereas at high dose (50 μM it rather decreased it. In vivo, in brain mitochondria from resveratrol treated young mice, we showed that complex I activity was increased, whereas the respiration rate was not improved. Moreover, in old mice with low antioxidant defenses, we demonstrated that complex I activation by resveratrol led to oxidative stress. These results bring new insights into the mechanism of action of resveratrol on mitochondria and highlight the importance of the balance between pro- and antioxidant effects of resveratrol depending on its dose and age. These parameters should be taken into account when clinical trials using resveratrol or analogues have to be designed.

Construction and preliminary validation of the Barcelona Immigration Stress Scale.

Science.gov (United States)

Tomás-Sábado, Joaquín; Qureshi, Adil; Antonin, Montserrat; Collazos, Francisco

2007-06-01

In the study of mental health and migration, an increasing number of researchers have shifted the focus away from the concept of acculturation towards the stress present in the migratory experience. The bulk of research on acculturative stress has been carried out in the United States, and thus the definition and measurement of the construct has been predicated on that cultural and demographic context, which is of dubious applicability in Europe in general, and Spain in particular. Further, some scales have focused on international students, which down-played the importance of the migratory process, because it deals with a special subset of people who are not formally immigrating. The Barcelona Immigration Stress Scale was developed to measure acculturative stress appropriate to immigrants in Spain, using expert and focus group review and has 42 items. The scale shows acceptable internal validity, and, consistent with other scales, suggests that immigration stress is a complex construct.

Study on photophysical properties of Eu(III) complexes with aromatic β-diketones – Role of charge transfer states in the energy migration

Energy Technology Data Exchange (ETDEWEB)

Räsänen, Markus, E-mail: mpvras@utu.fi [Department of Chemistry, University of Turku, FIN-20014 Turku (Finland); Takalo, Harri [DHR Finland Oy, Innotrac Diagnostics, Biolinja 12, FIN-20750 Turku (Finland); Rosenberg, Jaana; Mäkelä, Joonas [Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku (Finland); Haapakka, Keijo; Kankare, Jouko [Department of Chemistry, University of Turku, FIN-20014 Turku (Finland)

2014-02-15

We synthesized a set of aromatic β-diketones and measured the photophysical properties of their europium(III) complexes. According to these photophysical properties, the europium complexes can be divided into two groups: the complexes with or without the freely rotating amino-group (FRAG). On the basis of the experimental results, it can be concluded that in the FRAG complexes, the ligand-centered excitation energy is most probably transferred from a ligand to a coordinated europium via the intraligand charge transfer (ILCT) state. The temperature dependency of the lifetimes of the emissive {sup 5}D{sub 0} state revealed that in the FRAG complexes, the energy of the emissive {sup 5}D{sub 0} state is back-transferred to the ligand-to-metal charge transfer (LMCT) state and in the non-FRAG complexes, to the triplet state of the ligand. The most efficient complex synthesized was the europium complex of carbazole derivative L{sup 6} with the quantum yield of 47% and molar absorption coefficient of 70,400 M{sup −1}cm{sup −1}. -- Highlights: • We synthesized a set of substituted aromatic β-diketones and their Eu(III) complexes. • We measured the photophysical properties of these Eu(III) complexes. • Carbazole derivative of β-diketone forms the brightest Eu(III) complex. • The Jablonski diagrams proposed for the luminescence of these complexes.

NUMERICAL ANALYSIS OF THE STRESS-STRAIN STATE OF A ROPE STRAND WITH LINEAR CONTACT UNDER TENSION AND TORSION LOADING CONDITIONS

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Evgenij Kalentev

2017-06-01

Full Text Available The paper presents the results of a numerical analysis of the stress-strain state of a rope strand with linear contact under tension and torsion loading conditions. Calculations are done using the ANSYS software package. Different approaches to calculation of the stress-strain state of ropes are reviewed, and their advantages and deficiencies are considered. The analysis of the obtained results leads us to the conclusion that the proposed method can be used in engineering calculations.

Groundwater Modeling in Support of Water Resources Management and Planning under Complex Climate, Regulatory, and Economic Stresses

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Emin C. Dogrul

2016-12-01

Full Text Available Groundwater is an important resource that meets part or all of the water demand in many developed basins. Since it is an integral part of the hydrologic cycle, management of groundwater resources must consider not only the management of surface flows but also the variability in climate. In addition, agricultural and urban activities both affect the availability of water resources and are affected by it. Arguably, the Central Valley of the State of California, USA, can be considered a basin where all stresses that can possibly affect the management of groundwater resources seem to have come together: a vibrant economy that depends on water, a relatively dry climate, a disparity between water demand and availability both in time and space, heavily managed stream flows that are susceptible to water quality issues and sea level rise, degradation of aquifer conditions due to over-pumping, and degradation of the environment with multiple species becoming endangered. Over the past fifteen years, the California Department of Water Resources has developed and maintained the Integrated Water Flow Model (IWFM to aid in groundwater management and planning under complex, and often competing, requirements. This paper will describe features of IWFM as a generic modeling tool, and showcase several of its innovative applications within California.

Stress og insomni

DEFF Research Database (Denmark)

Jennum, Poul; Zachariae, Bobby

2012-01-01

Insomnia and stress are two conditions, which are strongly associated and appear to be pathophysiologically integrated: the occurrence of stress increases the risk of insomnia, insomnia exacerbates stress, and coexistence of both factors has a negative influence on their prognosis. Stress...... and insomnia thus share complex interactions and the mechanisms involved are insufficiently understood but involve both psychological and physiological processes. First choice interventions involve behavioural and cognitive strategies and, to a lesser extent, pharmacological treatment....

Moments of generalized Husimi distributions and complexity of many-body quantum states

International Nuclear Information System (INIS)

Sugita, Ayumu

2003-01-01

We consider generalized Husimi distributions for many-body systems, and show that their moments are good measures of complexity of many-body quantum states. Our construction of the Husimi distribution is based on the coherent state of the single-particle transformation group. Then the coherent states are independent-particle states, and, at the same time, the most localized states in the Husimi representation. Therefore delocalization of the Husimi distribution, which can be measured by the moments, is a sign of many-body correlation (entanglement). Since the delocalization of the Husimi distribution is also related to chaoticity of the dynamics, it suggests a relation between entanglement and chaos. Our definition of the Husimi distribution can be applied not only to systems of distinguishable particles, but also to those of identical particles, i.e., fermions and bosons. We derive an algebraic formula to evaluate the moments of the Husimi distribution

Perceived Sources of Occupational Stress among Primary School Teachers in Delta State of Nigeria

Science.gov (United States)

Akpochafo, G. O.

2012-01-01

This study investigated the most prevalent sources of occupational stress and also the demographic variables of gender, age and length of service among primary school teachers in Delta State. Two research questions and three hypotheses guided the study. The study used a descriptive survey design. The population was the primary school teachers in…

Mechanisms of charge-state determination in hydrogen-based impurity complexes in crystalline germanium

International Nuclear Information System (INIS)

Oliva, J.

1984-01-01

Recent experiments suggest that hydrogen may become bound to, and then tunnel around, substitutional carbon, silicon, or oxygen impurities in crystalline germanium. All these complexes are electrically active; [H,C] and [H,Si] are shallow acceptors, while [H,O] is a shallow donor. This paper attempts to elucidate the basic physical mechanisms controlling the charge state of such complexes as a function of the choice of the substitutional atom. A minimal-basis Bethe-cluster approach is used with the cluster comprising the ten-atom tetrahedral cage (including the substitutional atom) and enclosed H site, the latter coupled to all ten atoms of the cage. The important local correlation effect which tends to favor single occupation of the H site is modeled with a Hubbard-type term at that site. The charge state of the [H,C], [H,Si], and [H,O] complexes is associated with double occupation of the H site. Four aspects of the model are involved in favoring double occupation: (1) a low value of the H-site energy, (2) a reduced local correlation effect at the H site, (3) small hybridization between the H site and cage, and (4) a low value of the substitutional-site energy relative to that of the host. Results for the charge state for H at the cage center and for H near the substitutional atom are discussed in detail. Several useful formal results for local self-energies and local Green's functions are presented

Cation-mediated conversion of the state of charge in uranium arene inverted-sandwich complexes

Energy Technology Data Exchange (ETDEWEB)

Camp, Clement; Mougel, Victor; Pecaut, Jacques; Mazzanti, Marinella [Laboratoire de Reconnaissance Ionique et Chimie de Coordination, SCIB, UMR-E3 CEA-UJF, INAC, CEA-Grenoble (France); Maron, Laurent [LCPNO, CNRS and INSA, UPS, Universite de Toulouse (France)

2013-12-16

Two new arene inverted-sandwich complexes of uranium supported by siloxide ancillary ligands [K{U(OSi(OtBu)_3)_3}{sub 2}(μ-η{sup 6}:η{sup 6}-C{sub 7}H{sub 8})] (3) and [K{sub 2}{U(OSi(OtBu)_3)_3}{sub 2}(μ-η{sup 6}:η{sup 6}-C{sub 7}H{sub 8})] (4) were synthesized by the reduction of the parent arene-bridged complex [{U(OSi(OtBu)_3)_3}{sub 2}(μ-η{sup 6}:η{sup 6}-C{sub 7}H{sub 8})] (2) with stoichiometric amounts of KC{sub 8} yielding a rare family of inverted-sandwich complexes in three states of charge. The structural data and computational studies of the electronic structure are in agreement with the presence of high-valent uranium centers bridged by a reduced tetra-anionic toluene with the best formulation being U{sup V}-(arene{sup 4-})-U{sup V}, KU{sup IV}-(arene{sup 4-})-U{sup V}, and K{sub 2}U{sup IV}-(arene{sup 4-})-U{sup IV} for complexes 2, 3, and 4 respectively. The potassium cations in complexes 3 and 4 are coordinated to the siloxide ligands both in the solid state and in solution. The addition of KOTf (OTf=triflate) to the neutral compound 2 promotes its disproportionation to yield complexes 3 and 4 (depending on the stoichiometry) and the U{sup IV} mononuclear complex [U(OSi(OtBu){sub 3}){sub 3}(OTf)(thf){sub 2}] (5). This unprecedented reactivity demonstrates the key role of potassium for the stability of these complexes. (Copyright copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Changes in phase composition and stress state of surface layers of VK20 hard alloy after ion bombardment

International Nuclear Information System (INIS)

Platonov, G.L.; Leonov, E.Yu.; Anikin, V.N.; Anikeev, A.I.

1988-01-01

Titanium ion bombardment of the surface of the hard VK20 alloy is studied for its effect on variations in the phase and chemical composition of its surface layers. It is stated that ion treatment results in the appearance of the η-phase of Co 6 W 6 C composition in the surface layer of the VK20 alloy, in the increase of distortions and decrease of coherent scattering blocks of the hard alloy carbide phase. Such a bombardment is found to provoke a transition of the plane-stressed state of the hard alloy surface into the volume-stressed state. It is established that ion treatment does not cause an allotropic transition of the cobalt phase α-modification, formed during grinding of the hard alloy, into the β-modification

The effects of location, thermal stress, and residual stress on corner cracks in nozzles with cladding

International Nuclear Information System (INIS)

Besuner, P.M.; Cohen, L.M.; McLean, J.L.

1977-01-01

The stress intensity factors (Ksub(I)) for corner cracks in a boiling water reactor feedwater nozzle with stainless steel cladding are obtained for loading by internal pressure, and a fluid quench in the nozzle. Conditions with and without residual stress in the component are considered. The residual stress is simulated by means of a reference temperature change. The stress distribution for the uncracked structure is obtained from a three-dimensional finite element model. A three-dimensional influence function (IF) method, in conjunction with the boundary-integral equation method for structural analysis, is employed to compute Ksub(I) values from the uncracked structure's stress distribution. For each type of loading Ksub(I) values are given for cracks at 15 nozzle locations and for six crack depths. Reasonable agreement is noted between calculated and previously published pressure-induced Ksub(I) values. Comparisons are made to determine the effect on Ksub(I) of crack location, thermal stress, and residual stress as compared to pressure stress. For the thermal transient it is shown that Ksub(I) for small crack depths is maximized early in the transient while Ksub(I) for large cracks is maximized later, under steady state conditions. Ksub(I) computations should, therefore, be made for several transient time points and the maximum Ksub(I) for a given crack depth should be used for design analysis. It is concluded that the effects on Ksub(I) of location, thermal stresses, and residual stresses are significant and generally too complex to evalute without advanced numerical procedures. The utilized combination of finite element analysis of the uncracked structure and three-dimensional influence function analysis of the cracked structure is demonstrated

Stress Physiology of Lactic Acid Bacteria

Science.gov (United States)

Papadimitriou, Konstantinos; Alegría, Ángel; Bron, Peter A.; de Angelis, Maria; Gobbetti, Marco; Kleerebezem, Michiel; Lemos, José A.; Linares, Daniel M.; Ross, Paul; Stanton, Catherine; Turroni, Francesca; van Sinderen, Douwe; Varmanen, Pekka; Ventura, Marco; Zúñiga, Manuel; Tsakalidou, Effie

2016-01-01

SUMMARY Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms. The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by the technological implications of LAB robustness in the food industry. Survival of probiotic LAB in the host and the potential relatedness of LAB virulence to their stress resilience have intensified interest in the field. Thus, a wealth of information concerning stress responses exists today for strains as diverse as starter (e.g., Lactococcus lactis), probiotic (e.g., several Lactobacillus spp.), and pathogenic (e.g., Enterococcus and Streptococcus spp.) LAB. Here we present the state of the art for LAB stress behavior. We describe the multitude of stresses that LAB are confronted with, and we present the experimental context used to study the stress responses of LAB, focusing on adaptation, habituation, and cross-protection as well as on self-induced multistress resistance in stationary phase, biofilms, and dormancy. We also consider stress responses at the population and single-cell levels. Subsequently, we concentrate on the stress defense mechanisms that have been reported to date, grouping them according to their direct participation in preserving cell energy, defending macromolecules, and protecting the cell envelope. Stress-induced responses of probiotic LAB and commensal/pathogenic LAB are highlighted separately due to the complexity of the peculiar multistress conditions to which these bacteria are subjected in their hosts. Induction of prophages under environmental stresses is then discussed. Finally, we present systems-based strategies to characterize the “stressome” of LAB and to engineer new food-related and probiotic LAB with improved stress tolerance. PMID:27466284

Comparison of holographic and field theoretic complexities for time dependent thermofield double states

Science.gov (United States)

Yang, Run-Qiu; Niu, Chao; Zhang, Cheng-Yong; Kim, Keun-Young

2018-02-01

We compute the time-dependent complexity of the thermofield double states by four different proposals: two holographic proposals based on the "complexity-action" (CA) conjecture and "complexity-volume" (CV) conjecture, and two quantum field theoretic proposals based on the Fubini-Study metric (FS) and Finsler geometry (FG). We find that four different proposals yield both similarities and differences, which will be useful to deepen our understanding on the complexity and sharpen its definition. In particular, at early time the complexity linearly increase in the CV and FG proposals, linearly decreases in the FS proposal, and does not change in the CA proposal. In the late time limit, the CA, CV and FG proposals all show that the growth rate is 2 E/(πℏ) saturating the Lloyd's bound, while the FS proposal shows the growth rate is zero. It seems that the holographic CV conjecture and the field theoretic FG method are more correlated.

Effects of ligand substitution on the excited state dynamics of the Ru(dcbpy)(CO) 2I 2 complex

Science.gov (United States)

Lehtovuori, Viivi; Kallioinen, Jani; Myllyperkiö, Pasi; Haukka, Matti; Korppi-Tommola, Jouko

2003-11-01

Spectroscopic evidence suggest [PCCP 3 (2001) 1992] that illumination with visible light of the [ trans-I-Ru(dcbpy)(CO) 2I 2] (dcbpy= 4,4 '-dicarboxy-2,2 '-bipyridine) complex in solution induces dissociation of a CO group followed by reorganization of the ligands and attachment of a solvent molecule. In the present study, we report results on excited state dynamics of this ruthenium complex and its photoproduct. Femtosecond transient absorption measurements reveal dominance of excited state absorption of the reactant and the photoproduct [ cis-I-Ru(dcbpy)(CO)(Sol)I 2] (Sol=ethanol or acetonitrile) in the visible spectral region. The time-resolved measurements for the reactant at 77 K indicate interligand charge transfer from mixed Ru-I states to empty dcbpy orbitals. For the photoproduct, no such transfer was observed. In both complexes recovery from the lowest energy excited triplet state to the ground state occurs via two channels: radiative relaxation and a parallel barrier controlled non-radiative relaxation. The barrier is much higher in the reactant (about 850 cm -1) than in the product. A combination of DFT and ZINDO/CI calculations was used to estimate excited singlet and triplet spectra of the reactant and the product molecules. Calculated singlet-triplet difference spectra qualitatively match the observed transient spectra 500 fs after excitation supporting the idea that observed excited state relaxation occurs from the triplet states in both complexes.

Effects of ligand substitution on the excited state dynamics of the Ru(dcbpy)(CO)2I2 complex

International Nuclear Information System (INIS)

Lehtovuori, Viivi; Kallioinen, Jani; Myllyperkioe, Pasi; Haukka, Matti; Korppi-Tommola, Jouko

2003-01-01

Spectroscopic evidence suggest [PCCP 3 (2001) 1992] that illumination with visible light of the [trans-I-Ru(dcbpy)(CO) 2 I 2 ] (dcbpy4,4 ' -dicarboxy-2,2 ' -bipyridine) complex in solution induces dissociation of a CO group followed by reorganization of the ligands and attachment of a solvent molecule. In the present study, we report results on excited state dynamics of this ruthenium complex and its photoproduct. Femtosecond transient absorption measurements reveal dominance of excited state absorption of the reactant and the photoproduct [cis-I-Ru(dcbpy)(CO)(Sol)I 2 ] (Sol=ethanol or acetonitrile) in the visible spectral region. The time-resolved measurements for the reactant at 77 K indicate interligand charge transfer from mixed Ru-I states to empty dcbpy orbitals. For the photoproduct, no such transfer was observed. In both complexes recovery from the lowest energy excited triplet state to the ground state occurs via two channels: radiative relaxation and a parallel barrier controlled non-radiative relaxation. The barrier is much higher in the reactant (about 850 cm -1 ) than in the product. A combination of DFT and ZINDO/CI calculations was used to estimate excited singlet and triplet spectra of the reactant and the product molecules. Calculated singlet-triplet difference spectra qualitatively match the observed transient spectra 500 fs after excitation supporting the idea that observed excited state relaxation occurs from the triplet states in both complexes