Focus small to find big - the microbeam story.

Science.gov (United States)

Wu, Jinhua; Hei, Tom K

2017-08-29

Even though the first ultraviolet microbeam was described by S. Tschachotin back in 1912, the development of sophisticated micro-irradiation facilities only began to flourish in the late 1980s. In this article, we highlight significant microbeam experiments, describe the latest microbeam irradiator configurations and critical discoveries made by using the microbeam apparatus. Modern radiological microbeams facilities are capable of producing a beam size of a few micrometers, or even tens of nanometers in size, and can deposit radiation with high precision within a cellular target. In the past three decades, a variety of microbeams has been developed to deliver a range of radiations including charged particles, X-rays, and electrons. Despite the original intention for their development to measure the effects of a single radiation track, the ability to target radiation with microbeams at sub-cellular targets has been extensively used to investigate radiation-induced biological responses within cells. Studies conducted using microbeams to target specific cells in a tissue have elucidated bystander responses, and further studies have shown reactive oxygen species (ROS) and reactive nitrogen species (RNS) play critical roles in the process. The radiation-induced abscopal effect, which has a profound impact on cancer radiotherapy, further reaffirmed the importance of bystander effects. Finally, by targeting sub-cellular compartments with a microbeam, we have reported cytoplasmic-specific biological responses. Despite the common dogma that nuclear DNA is the primary target for radiation-induced cell death and carcinogenesis, studies conducted using microbeam suggested that targeted cytoplasmic irradiation induces mitochondrial dysfunction, cellular stress, and genomic instability. A more recent development in microbeam technology includes application of mouse models to visualize in vivo DNA double-strand breaks. Microbeams are making important contributions towards our

Active mems microbeam device for gas detection

KAUST Repository

Bouchaala, Adam M.

2017-10-05

Sensors and active switches for applications in gas detection and other fields are described. The devices are based on the softening and hardening nonlinear response behaviors of microelectromechanical systems (MEMS) clamped-clamped microbeams. In that context, embodiments of gas-triggered MEMS microbeam sensors and switches are described. The microbeam devices can be coated with a Metal-Organic Framework to achieve high sensitivity. For gas sensing, an amplitude-based tracking algorithm can be used to quantify an amount of gas captured by the devices according to frequency shift. Noise analysis is also conducted according to the embodiments, which shows that the microbeam devices have high stability against thermal noise. The microbeam devices are also suitable for the generation of binary sensing information for alarming, for example.

One hundred years ago: Start of the Optometry School at Columbia University.

Science.gov (United States)

Goss, David A

2010-10-01

An optometry school at Columbia University entered its first students in 1910. This was the first optometry school at a university. This article examines what was said in optometry periodicals of 1910 and 1911 about this significant development.

Dynamics of Microbeams under Multi-Frequency Excitations

KAUST Repository

Ibrahim, Alwathiqbellah

2017-01-24

This paper presents an investigation of the dynamics of microbeams under multiple harmonic electrostatic excitation frequencies. First, the response of a cantilever microbeam to two alternating current (AC) source excitation is examined. We show by simulations the response of the microbeam at primary resonance (near the fundamental natural frequency) and at secondary resonances (near half, superharmonic, and twice, subharmonic, the fundamental natural frequency). A multimode Galerkin method combined with the Euler-Bernoulli beam equation, accounting for the nonlinear electrostatic force, has been used to develop a reduced order model. The response of the cantilever microbeam to three AC source excitation is also investigated and shown as a promising technique to enhance the bandwidth of resonators. Finally, an experimental study of a clamped-clamped microbeam is conducted, demonstrating the multi-frequency excitation resonances using two, three, and four AC sources.

Dynamics of Microbeams under Multi-Frequency Excitations

KAUST Repository

Ibrahim, Alwathiqbellah; Jaber, Nizar; Chandran, Akhil; Thirupathi, Maloth; Younis, Mohammad I.

2017-01-01

This paper presents an investigation of the dynamics of microbeams under multiple harmonic electrostatic excitation frequencies. First, the response of a cantilever microbeam to two alternating current (AC) source excitation is examined. We show by simulations the response of the microbeam at primary resonance (near the fundamental natural frequency) and at secondary resonances (near half, superharmonic, and twice, subharmonic, the fundamental natural frequency). A multimode Galerkin method combined with the Euler-Bernoulli beam equation, accounting for the nonlinear electrostatic force, has been used to develop a reduced order model. The response of the cantilever microbeam to three AC source excitation is also investigated and shown as a promising technique to enhance the bandwidth of resonators. Finally, an experimental study of a clamped-clamped microbeam is conducted, demonstrating the multi-frequency excitation resonances using two, three, and four AC sources.

Microbeam evolution: From single cell irradiation to preclinical studies

DEFF Research Database (Denmark)

Ghita, Mihaela; Fernandez-Palomo, Cristian; Fukunaga, Hisanori

2018-01-01

Purpose: This review follows the development of microbeam technology from the early days of single cell irradiations, to investigations of specific cellular mechanisms and to the development of new treatment modalities in vivo. A number of microbeam applications are discussed with a focus on prec...... to deliver radiotherapy using plane parallel microbeams, in Microbeam Radiotherapy (MRT)....

The Amsterdam proton microbeam

International Nuclear Information System (INIS)

Bos, A.J.J.

1984-01-01

The aim of the work presented in this thesis is to develop a microbeam setup such that small beam spot sizes can be produced routinely, and to investigate the capabilities of the setup for micro-PIXE analysis. The development and performance of the Amsterdam proton microbeam setup are described. The capabilities of the setup for micro-PIXE are shown with an investigation into the presence of trace elements in human hair. (Auth.)

Wide area scanning system and carbon microbeams at the external microbeam facility of the INFN LABEC laboratory in Florence

International Nuclear Information System (INIS)

Giuntini, L.; Massi, M.; Calusi, S.; Castelli, L.; Carraresi, L.; Fedi, M.E.; Gelli, N.; Liccioli, L.; Mandò, P.A.; Mazzinghi, A.; Palla, L.; Romano, F.P.

2015-01-01

Recently, developments have been made to the external scanning microbeam of INFN-LABEC laboratory in Florence. A new system for mechanical sample scanning was implemented. This system allows us to acquire large maps (up to 20 × 20 cm 2 ), of great interest in the Cultural Heritage field. In parallel, the possibility of using carbon microbeams for experiments, such as, for example, ion beam modification of materials and MeV Secondary Ion Mass Spectrometry, has been investigated. As a test application, Particle Induced X-ray Emission with carbon microbeams has been performed on a lapis lazuli stone. First results for both wide area imaging and external carbon microbeams are briefly reported

Genome-wide transcription responses to synchrotron microbeam radiotherapy.

Science.gov (United States)

Sprung, Carl N; Yang, Yuqing; Forrester, Helen B; Li, Jason; Zaitseva, Marina; Cann, Leonie; Restall, Tina; Anderson, Robin L; Crosbie, Jeffrey C; Rogers, Peter A W

2012-10-01

The majority of cancer patients achieve benefit from radiotherapy. A significant limitation of radiotherapy is its relatively low therapeutic index, defined as the maximum radiation dose that causes acceptable normal tissue damage to the minimum dose required to achieve tumor control. Recently, a new radiotherapy modality using synchrotron-generated X-ray microbeam radiotherapy has been demonstrated in animal models to ablate tumors with concurrent sparing of normal tissue. Very little work has been undertaken into the cellular and molecular mechanisms that differentiate microbeam radiotherapy from broad beam. The purpose of this study was to investigate and compare the whole genome transcriptional response of in vivo microbeam radiotherapy versus broad beam irradiated tumors. We hypothesized that gene expression changes after microbeam radiotherapy are different from those seen after broad beam. We found that in EMT6.5 tumors at 4-48 h postirradiation, microbeam radiotherapy differentially regulates a number of genes, including major histocompatibility complex (MHC) class II antigen gene family members, and other immunity-related genes including Ciita, Ifng, Cxcl1, Cxcl9, Indo and Ubd when compared to broad beam. Our findings demonstrate molecular differences in the tumor response to microbeam versus broad beam irradiation and these differences provide insight into the underlying mechanisms of microbeam radiotherapy and broad beam.

Wide area scanning system and carbon microbeams at the external microbeam facility of the INFN LABEC laboratory in Florence

Energy Technology Data Exchange (ETDEWEB)

Giuntini, L. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Massi, M. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Calusi, S. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Castelli, L. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Carraresi, L. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Fedi, M.E.; Gelli, N. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Liccioli, L.; Mandò, P.A.; Mazzinghi, A. [Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Dipartimento di Fisica e Astronomia, Università di Firenze, Via Sansone 1, I-50019 Sesto Fiorentino, Firenze (Italy); Palla, L. [INFN, Sezione di Pisa and Università di Pisa, Largo B. Pontecorvo 3, I-56127 Pisa (Italy); Romano, F.P. [Consiglio Nazionale delle Ricerche (CNR), Istituto per i Beni Archeologici e Monumentali (IBAM), Via Biblioteca, 4, 95124 Catania (Italy); Istituto Nazionale di Fisica Nucleare (INFN), LNS, Via S.Sofia 62, 95125 Catania (Italy); and others

2015-04-01

Recently, developments have been made to the external scanning microbeam of INFN-LABEC laboratory in Florence. A new system for mechanical sample scanning was implemented. This system allows us to acquire large maps (up to 20 × 20 cm{sup 2}), of great interest in the Cultural Heritage field. In parallel, the possibility of using carbon microbeams for experiments, such as, for example, ion beam modification of materials and MeV Secondary Ion Mass Spectrometry, has been investigated. As a test application, Particle Induced X-ray Emission with carbon microbeams has been performed on a lapis lazuli stone. First results for both wide area imaging and external carbon microbeams are briefly reported.

The new Sandia light ion microbeam

Energy Technology Data Exchange (ETDEWEB)

Vizkelethy, G., E-mail: gvizkel@sandia.gov [Sandia National Laboratories, P.O. Box 5800, MS 1056, Albuquerque, NM 87185 (United States); Doyle, B.L. [Sandia National Laboratories, P.O. Box 5800, MS 1056, Albuquerque, NM 87185 (United States); McDaniel, F.L. [Sandia National Laboratories, P.O. Box 5800, MS 1056, Albuquerque, NM 87185 (United States); University of North Texas, Denton, TX 76203 (United States)

2012-02-15

The Ion Beam Laboratory of Sandia National Laboratories (SNL) was recently relocated into a brand new building. The 6 MV High Voltage Engineering (HVE) tandem accelerator (hosting the heavy ion microbeam and several analytical beam lines) and the 350 kV HVE implanter with a nanobeam were moved to the new building. There were several new pieces of equipment acquired associated with the move, among them a new high brightness 3 MV Pelletron accelerator, a high resolution light ion microbeam, a nanoimplanter, and a transmission electron microscope (TEM) connected to the tandem accelerator. In this paper this new facility will be described, and initial results of the new microbeam will be presented.

High resolution 3D imaging of synchrotron generated microbeams

Energy Technology Data Exchange (ETDEWEB)

Gagliardi, Frank M., E-mail: frank.gagliardi@wbrc.org.au [Alfred Health Radiation Oncology, The Alfred, Melbourne, Victoria 3004, Australia and School of Medical Sciences, RMIT University, Bundoora, Victoria 3083 (Australia); Cornelius, Iwan [Imaging and Medical Beamline, Australian Synchrotron, Clayton, Victoria 3168, Australia and Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales 2500 (Australia); Blencowe, Anton [Division of Health Sciences, School of Pharmacy and Medical Sciences, The University of South Australia, Adelaide, South Australia 5000, Australia and Division of Information Technology, Engineering and the Environment, Mawson Institute, University of South Australia, Mawson Lakes, South Australia 5095 (Australia); Franich, Rick D. [School of Applied Sciences and Health Innovations Research Institute, RMIT University, Melbourne, Victoria 3000 (Australia); Geso, Moshi [School of Medical Sciences, RMIT University, Bundoora, Victoria 3083 (Australia)

2015-12-15

Purpose: Microbeam radiation therapy (MRT) techniques are under investigation at synchrotrons worldwide. Favourable outcomes from animal and cell culture studies have proven the efficacy of MRT. The aim of MRT researchers currently is to progress to human clinical trials in the near future. The purpose of this study was to demonstrate the high resolution and 3D imaging of synchrotron generated microbeams in PRESAGE® dosimeters using laser fluorescence confocal microscopy. Methods: Water equivalent PRESAGE® dosimeters were fabricated and irradiated with microbeams on the Imaging and Medical Beamline at the Australian Synchrotron. Microbeam arrays comprised of microbeams 25–50 μm wide with 200 or 400 μm peak-to-peak spacing were delivered as single, cross-fire, multidirectional, and interspersed arrays. Imaging of the dosimeters was performed using a NIKON A1 laser fluorescence confocal microscope. Results: The spatial fractionation of the MRT beams was clearly visible in 2D and up to 9 mm in depth. Individual microbeams were easily resolved with the full width at half maximum of microbeams measured on images with resolutions of as low as 0.09 μm/pixel. Profiles obtained demonstrated the change of the peak-to-valley dose ratio for interspersed MRT microbeam arrays and subtle variations in the sample positioning by the sample stage goniometer were measured. Conclusions: Laser fluorescence confocal microscopy of MRT irradiated PRESAGE® dosimeters has been validated in this study as a high resolution imaging tool for the independent spatial and geometrical verification of MRT beam delivery.

High resolution 3D imaging of synchrotron generated microbeams

International Nuclear Information System (INIS)

Gagliardi, Frank M.; Cornelius, Iwan; Blencowe, Anton; Franich, Rick D.; Geso, Moshi

2015-01-01

Purpose: Microbeam radiation therapy (MRT) techniques are under investigation at synchrotrons worldwide. Favourable outcomes from animal and cell culture studies have proven the efficacy of MRT. The aim of MRT researchers currently is to progress to human clinical trials in the near future. The purpose of this study was to demonstrate the high resolution and 3D imaging of synchrotron generated microbeams in PRESAGE® dosimeters using laser fluorescence confocal microscopy. Methods: Water equivalent PRESAGE® dosimeters were fabricated and irradiated with microbeams on the Imaging and Medical Beamline at the Australian Synchrotron. Microbeam arrays comprised of microbeams 25–50 μm wide with 200 or 400 μm peak-to-peak spacing were delivered as single, cross-fire, multidirectional, and interspersed arrays. Imaging of the dosimeters was performed using a NIKON A1 laser fluorescence confocal microscope. Results: The spatial fractionation of the MRT beams was clearly visible in 2D and up to 9 mm in depth. Individual microbeams were easily resolved with the full width at half maximum of microbeams measured on images with resolutions of as low as 0.09 μm/pixel. Profiles obtained demonstrated the change of the peak-to-valley dose ratio for interspersed MRT microbeam arrays and subtle variations in the sample positioning by the sample stage goniometer were measured. Conclusions: Laser fluorescence confocal microscopy of MRT irradiated PRESAGE® dosimeters has been validated in this study as a high resolution imaging tool for the independent spatial and geometrical verification of MRT beam delivery

The Columbia Social Essayists

Directory of Open Access Journals (Sweden)

Albert J. Bergesen

2015-08-01

Full Text Available Wallerstein came of age intellectually at Columbia University, where he was an undergraduate, graduate student and faculty member for a quarter of a century (1947-1971. While we often think of his work on African politics and his concern with third world development as precur-sors to world-system theory, a large part of his intellectual biography was shaped by those Columbia years. They mark the high point of a triple hegemony of university, city, and nation, as at this time Columbia was the leading university in the leading city of the hegemonic nation. It was a time before the 1960s when the New Left and Berkeley would challenge the centrality of New York and Columbia as undisputed centers of American social thought and it was before what would be called the policy intellectuals would emerge in Washington DC in the 1970s/80s. It was also a time before the great in?ux of federal money in the 1960s which spurred social research and lifted other universities to prominence. It was a time of what I will call The Columbia Social Essayists, referring to scholar/intellectuals such as C. Wright Mills, Daniel Bell, Lionel Trilling, Richard Hofstadter and Meyer Schapiro.

Response of avian embryonic brain to spatially segmented x-ray microbeams.

Science.gov (United States)

Dilmanian, F A; Morris, G M; Le Duc, G; Huang, X; Ren, B; Bacarian, T; Allen, J C; Kalef-Ezra, J; Orion, I; Rosen, E M; Sandhu, T; Sathé, P; Wu, X Y; Zhong, Z; Shivaprasad, H L

2001-05-01

Duck embryo was studied as a model for assessing the effects of microbeam radiation therapy (MRT) on the human infant brain. Because of the high risk of radiation-induced disruption of the developmental process in the immature brain, conventional wide-beam radiotherapy of brain tumors is seldom carried out in infants under the age of three. Other types of treatment for pediatric brain tumors are frequently ineffective. Recent findings from studies in Grenoble on the brain of suckling rats indicate that MRT could be of benefit for the treatment of early childhood tumors. In our studies, duck embryos were irradiated at 3-4 days prior to hatching. Irradiation was carried out using a single exposure of synchrotron-generated X-rays, either in the form of parallel microplanar beams (microbeams), or as non-segmented broad beam. The individual microplanar beams had a width of 27 microm and height of 11 mm, and a center-to-center spacing of 100 microm. Doses to the exposed areas of embryo brain were 40, 80, 160 and 450 Gy (in-slice dose) for the microbeam, and 6, 12 and 18 Gy for the broad beam. The biological end point employed in the study was ataxia. This neurological symptom of radiation damage to the brain developed within 75 days of hatching. Histopathological analysis of brain tissue did not reveal any radiation induced lesions for microbeam doses of 40-160 Gy (in-slice), although some incidences of ataxia were observed in that dose group. However, severe brain lesions did occur in animals in the 450 Gy microbeam dose groups, and mild lesions in the 18 Gy broad beam dose group. These results indicate that embryonic duck brain has an appreciably higher tolerance to the microbeam modality, as compared to the broad beam modality. When the microbeam dose was normalized to the full volume of the irradiated tissue. i.e., the dose averaged over microbeams and the space between the microbeams, brain tolerance was estimated to be about three times higher to microbeam

NCT program at the University of Missouri-Columbia

International Nuclear Information System (INIS)

Brugger, R.M.; Shih, J.A.; Wu, H.S.; Liu, H.B.; Luo, X.S.

1992-01-01

At the University of Missouri-Columbia (MU), developments continue on specific parts of NCT. These are the epithermal beam design, Gd as an alternative agent to B, dose predictions and treatment planning, and accelerator based neutron sources. At the workshop on 'Neutron Beam Design, Development and Performance' held in Boston in March 1989, beam designs for a number of epithermal neutron beams were presented. Among this set was a design for an epithermal beam from the Missouri University Research Reactor (MURR). The Monte Carlo calculations for the neutron fluxes and gamma doses of this beam showed that, if built, this beam would be a very clean and intense epithermal neutron beam for NCT. Since that meeting, improvements have been made in the design to accommodate a beam shutter and to provide more flexibility in patient positioning. Also, capital cost and operating cost projections have been made

High energy ion hit technique to local area using microbeam

Energy Technology Data Exchange (ETDEWEB)

Tanaka, Ryuichi; Kamiya, Tomihiro; Suda, Tamotsu; Sakai, Takuro; Hirao, Toshio; Kobayashi, Yasuhiko; Watanabe, Hiroshi [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

1997-03-01

Single energetic ion hit technique has been developed as an application of ion microbeam technique, in order to study the effect of local damage or injury to materials and living organisms. The overall performance is basically defined by those of separate techniques: microbeam formation, microbeam positioning, single ion detection, detection signal processing, hit timing control, and hit verification. Recent progress on the developments of these techniques at JAERI-TIARA facility are reviewed. (author)

Synchrotron microbeam radiation therapy for rat brain tumor palliation-influence of the microbeam width at constant valley dose

International Nuclear Information System (INIS)

Serduc, Raphael; Fonta, Caroline; Renaud, Luc; Bouchet, Audrey; Braeuer-Krisch, Elke; Sarun, Sukhena; Bravin, Alberto; Le Duc, Geraldine; Laissue, Jean A; Spiga, Jenny; Boutonnat, Jean; Siegbahn, Erik Albert; Esteve, Francois

2009-01-01

To analyze the effects of the microbeam width (25, 50 and 75 μm) on the survival of 9L gliosarcoma tumor-bearing rats and on toxicity in normal tissues in normal rats after microbeam radiation therapy (MRT), 9L gliosarcomas implanted in rat brains, as well as in normal rat brains, were irradiated in the MRT mode. Three configurations (MRT25, MRT50, MRT75), each using two orthogonally intersecting arrays of either 25, 50 or 75 μm wide microbeams, all spaced 211 μm on center, were tested. For each configuration, peak entrance doses of 860, 480 and 320 Gy, respectively, were calculated to produce an identical valley dose of 18 Gy per individual array at the center of the tumor. Two, 7 and 14 days after radiation treatment, 42 rats were killed to evaluate histopathologically the extent of tumor necrosis, and the presence of proliferating tumors cells and tumor vessels. The median survival times of the normal rats were 4.5, 68 and 48 days for MRT25, 50 and 75, respectively. The combination of the highest entrance doses (860 Gy per array) with 25 μm wide beams (MRT25) resulted in a cumulative valley dose of 36 Gy and was excessively toxic, as it led to early death of all normal rats and of ∼50% of tumor-bearing rats. The short survival times, particularly of rats in the MRT25 group, restricted adequate observance of the therapeutic effect of the method on tumor-bearing rats. However, microbeams of 50 μm width led to the best median survival time after 9L gliosarcoma MRT treatment and appeared as the better compromise between tumor control and normal brain toxicity compared with 75 μm or 25 μm widths when used with a 211 μm on-center distance. Despite very high radiation doses, the tumors were not sterilized; viable proliferating tumor cells remained present at the tumor margin. This study shows that microbeam width and peak entrance doses strongly influence tumor responses and normal brain toxicity, even if valley doses are kept constant in all groups. The use

Synchrotron microbeam radiation therapy for rat brain tumor palliation-influence of the microbeam width at constant valley dose

Energy Technology Data Exchange (ETDEWEB)

Serduc, Raphael; Fonta, Caroline; Renaud, Luc [Universite de Toulouse, UPS, Centre de Recherche Cerveau et Cognition (France); Bouchet, Audrey; Braeuer-Krisch, Elke; Sarun, Sukhena; Bravin, Alberto; Le Duc, Geraldine [European Synchrotron Radiation Facility, F38043 Grenoble (France); Laissue, Jean A [Institute of Pathology, University of Bern (Switzerland); Spiga, Jenny [Department of Physics, University of Cagliari, s.p. Monserrato-Sestu, Monserrato (Canada) 09042 (Italy); Boutonnat, Jean [TIMC lab, UMR CNRS 5525, Univ Joseph Fourier, CHU, Grenoble (France); Siegbahn, Erik Albert [Department of Medical Physics, Karolinska Universitetssjukhuset, 17176 Stockholm (Sweden); Esteve, Francois [INSERM U836, Equipe 6, Institut des Neurosciences de Grenoble, 38043 Grenoble Cedex (France)], E-mail: raph.serduc@gmail.com

2009-11-07

To analyze the effects of the microbeam width (25, 50 and 75 {mu}m) on the survival of 9L gliosarcoma tumor-bearing rats and on toxicity in normal tissues in normal rats after microbeam radiation therapy (MRT), 9L gliosarcomas implanted in rat brains, as well as in normal rat brains, were irradiated in the MRT mode. Three configurations (MRT25, MRT50, MRT75), each using two orthogonally intersecting arrays of either 25, 50 or 75 {mu}m wide microbeams, all spaced 211 {mu}m on center, were tested. For each configuration, peak entrance doses of 860, 480 and 320 Gy, respectively, were calculated to produce an identical valley dose of 18 Gy per individual array at the center of the tumor. Two, 7 and 14 days after radiation treatment, 42 rats were killed to evaluate histopathologically the extent of tumor necrosis, and the presence of proliferating tumors cells and tumor vessels. The median survival times of the normal rats were 4.5, 68 and 48 days for MRT25, 50 and 75, respectively. The combination of the highest entrance doses (860 Gy per array) with 25 {mu}m wide beams (MRT25) resulted in a cumulative valley dose of 36 Gy and was excessively toxic, as it led to early death of all normal rats and of {approx}50% of tumor-bearing rats. The short survival times, particularly of rats in the MRT25 group, restricted adequate observance of the therapeutic effect of the method on tumor-bearing rats. However, microbeams of 50 {mu}m width led to the best median survival time after 9L gliosarcoma MRT treatment and appeared as the better compromise between tumor control and normal brain toxicity compared with 75 {mu}m or 25 {mu}m widths when used with a 211 {mu}m on-center distance. Despite very high radiation doses, the tumors were not sterilized; viable proliferating tumor cells remained present at the tumor margin. This study shows that microbeam width and peak entrance doses strongly influence tumor responses and normal brain toxicity, even if valley doses are kept constant in

Techniques and multi-disciplinary applications of ion microbeam

International Nuclear Information System (INIS)

Du Guanghua

2012-01-01

Beam of MeV ions form particle accelerators can be confined by collimators or focused by electrical/magnetic quadruples into micrometer size, and this microbeam can be used to obtain spatial information or radiation effect in solids and biological samples. This paper reviews the technical developments and the multi-disciplinary applications of microbeam, including ion beam analysis, single event effect in semiconductor devices, proton beam writing and cellular response to targeted particle irradiations. Finally, the high-energy heavy-ion microbeam facility at the Institute of Modern Physics of Chinese Academy of Sciences is introduced, which has successfully focused 1 GeV Carbon ions into a beam spot of 1 μm × 2 μm in air. (authors)

Conceptual design for real time monitoring of electron microbeam

International Nuclear Information System (INIS)

Kim, Ji Seok; Kim, Hyun Ki; Jang, Mee; Choi, Chang Woon; Sun, Gwang Min; Lee, Jai Ki

2008-01-01

It is recognized that the microbeam is powerful system to understand the interaction of ionizing radiation with cells. Especially, electron microbeam system is useful to investigate the effect of low-LET radiation for cells. Electron microbeam has been developed in KIRAMS. It can irradiate the small volume in cell level by collimator and electromagnetic field and give local dose to individual cell by controlling the number of electrons. When the electron microbeam irradiates the individual cell, however, there is a possibility to change the current and intended trajectory of electron beam. Because this possibility introduces the uncertainty of dose, it is necessary to monitor the trajectory and current of electron beam. This study deals with development of real time monitoring device to confirm beam quality and to control if necessary during experiment. Consequently we designed dual monitoring device to solve various factors. And we optimize the design by simulation. (author)

Update on the University of Missouri-Columbia Research Reactor Upgrade

Energy Technology Data Exchange (ETDEWEB)

McKibben, J C; Rhyne, J J [University of Missouri-Columbia (United States)

1992-07-01

The University of Missouri-Columbia (MU) is in the process of upgrading the research and operational capabilities of the MU Research Reactor (MURR) and associated facilities. The plans include an expanded research building that will double the laboratory space, the addition of new research programs, instrumentation and equipment, a cold neutron source, and improved reactor systems. These enhancements, which are in various stages of completion, will greatly expand the present active multidisciplinary research programs at MURR.

Proton microbeam irradiation effects on PtBA polymer

Indian Academy of Sciences (India)

Microbeam irradiation effects on poly-tert-butyl-acrylate (PtBA) polymer using 2.0 MeV proton microbeam are reported. Preliminary results on pattern formation on PtBA are carried out as a function of fluence. After writing the pattern, a thin layer of Ge is deposited. Distribution of Ge in pristine and ion beam patterned surface ...

Nonlinear analysis of thermally and electrically actuated functionally graded material microbeam.

Science.gov (United States)

Li, Yingli; Meguid, S A; Fu, Yiming; Xu, Daolin

2014-02-08

In this paper, we provide a unified and self-consistent treatment of a functionally graded material (FGM) microbeam with varying thermal conductivity subjected to non-uniform or uniform temperature field. Specifically, it is our objective to determine the effect of the microscopic size of the beam, the electrostatic gap, the temperature field and material property on the pull-in voltage of the microbeam under different boundary conditions. The non-uniform temperature field is obtained by integrating the steady-state heat conduction equation. The governing equations account for the microbeam size by introducing an internal material length-scale parameter that is based on the modified couple stress theory. Furthermore, it takes into account Casimir and van der Waals forces, and the associated electrostatic force with the first-order fringing field effects. The resulting nonlinear differential equations were converted to a coupled system of algebraic equations using the differential quadrature method. The outcome of our work shows the dramatic effect and dependence of the pull-in voltage of the FGM microbeam upon the temperature field, its gradient for a given boundary condition. Specifically, both uniform and non-uniform thermal loading can actuate the FGM microbeam even without an applied voltage. Our work also reveals that the non-uniform temperature field is more effective than the uniform temperature field in actuating a FGM cantilever-type microbeam. For the clamped-clamped case, care must be taken to account for the effective use of thermal loading in the design of microbeams. It is also observed that uniform thermal loading will lead to a reduction in the pull-in voltage of a FGM microbeam for all the three boundary conditions considered.

The Interdisciplinary Course in the Legal Aspects of Noise Pollution at Columbia University.

Science.gov (United States)

Harris, Cyril M.; Rosenthal, Albert J.

1981-01-01

A course in the legal aspects of noise pollution, cross-listed for students in Columbia University's Law and Engineering Schools, is described. Although noise is used as the major source of environmental pollution in this course, the principles and methodology discussed apply to other forms of environmental law. (MLW)

Evaluation of tests in 4x4 assemblies carried out in Columbia University

International Nuclear Information System (INIS)

Pedron, M.Q.

1989-01-01

Tests in 4x4 assemblies with BWR characteristics carried out in Columbia University are analysed, using the PANTERA-1P computer code. The experiments aim for measuring fluid, flow and enthalpies in exits of two subchannels, the coldest and hottest using iso kinetic sampling method. (M.C.K.)

PREFACE: Proceedings of the 11th European Workshop of the European Microbeam Analysis Society (EMAS) on Modern Developments and Applications in Microbeam Analysis

Science.gov (United States)

2010-07-01

young scientist for her talk entitled Application of focussed ion beam technique for TEM multilayer materials examination. This volume contains the full texts of 5 of the invited plenary lectures and of 24 papers on related topics originating from the posters presented at the workshop. All the papers have been subjected to peer review by a least two referees. January 2009 Acknowledgements On behalf of the European Microbeam Analysis Society I would like to thank all the invited speakers, session chairs and members of the discussion panels for making the meeting such a great success. Special thanks go to Michal Zelechower and Luc Van't dack who directed the organisation of the workshop giving freely of their time and talents. As was the case for previous workshops, the EMAS board in corpore was responsible for the scientific programme. I am particularly grateful to the exhibiting companies and sustaining members for their generous support of the workshop. In this context I would like particularly to mention: Silesian University of Technology, Gliwice Gdansk University of Technology Polish Society for Microscopy (PTMi), Krakow Polish Academy of Sciences - Materials Science Committee, Warsaw Polish Academy of Sciences - Institute of Metallurgy and Materials Science, Krakow Polish Academy of Sciences - Institute of Physics, Warsaw AGH University of Science and Technology, Krakow Warsaw University of Technology Below is a combined list of the exhibiting companies and sponsors of the workshop: Ametek GmbH (Germany) Blackwell Publishing Ltd (UK) Bruker AXS Microanalysis GmbH (Germany) Cameca SA (France) Carl Zeiss SMT GmbH (Germany) COMEF Aparatura Naukowo-Badawcza (Poland) EU-JRC: Inst. for Transuranium Elements (Germany) FEI Company (The Netherlands) IfG - Institute for Scientific Instruments GmbH (Germany) Jeol (Europe) SAS (France) John Wiley & Sons (UK) Olympus Soft Imaging Solutions GmbH (Germany) Oxford Instruments NanoAnalysis Ltd (UK) Probe Software, Inc. (USA

Heavy Ion Microbeam- and Broadbeam-Induced Transients in SiGe HBTs

Science.gov (United States)

Pellish, Jonathan A.; Reed, Robert A.; McMorrow, Dale; Vizkelethy, Gyorgy; Ferlet-Cavrois, Veronique; Baggio, Jacques; Duhamel, Olivier; Moen, Kurt A.; Phillips, Stanley D.; Diestelhorst, Ryan M.;

MOSFET dosimetry of the radiation therapy microbeams at the European synchrotron radiation facility

International Nuclear Information System (INIS)

Rozenfeld, A.; Lerch, M.

2002-01-01

Full text: We have developed an innovative on-line MOSFET readout system for use in the quality assurance of radiation treatment beams. Recently the system has found application in areas where excellent spatial resolution is also a requirement in the quality assurance process, for example IMRT, and microbeam radiation therapy. The excellent spatial resolution is achieved by using a quadruple RADFET TM chip in 'edge on' mode. In developing this approach we have found that the system can be utilised to determine any error in the beam profile measurements due to misalignment of RADFET with respect to the radiation beam or microbeam. Using this approach will ensure that the excellent spatial resolution of the RADFET used in 'edge-on' mode is fully utilised. In this work we report on dosimetry measurements performed at the microbeam radiation therapy beamline located at the European Synchrotron Radiation Facility. The synchrotron planar array microbeam with size 10-30 μm and pitch ∼200 μm has found an important application in microbeam radiation therapy (MRT) of brain tumours in infants for whom other kinds of radiotherapy are inadequate and/or unsafe. The radiation damage from an array of parallel microbeams correlates strongly with the range of peak-valley dose ratios (PVDR), ie, the range of the ratio of the absorbed dose to tissue directly in line with the mid-plane of the microbeam to that in the mid-plane between adjacent microbeams. Novel physical dosimetry of the microbeams using the online MOSFET reader system will be presented. Comparison of the experimental results with both GaF film measurements and Monte Carlo computer-simulated dosimetry are described here for selected points in the peak and valley regions of a microbeam-irradiated tissue phantom

Heavy Ion Microbeam- and Broadbeam-Induced Current Transients in SiGe HBTs

Science.gov (United States)

Pellish, Jonathan A.; Reed, R. A.; McMorrow, D.; Vizkelethy, G.; Ferlet-Cavrois, V.; Baggio, J.; Duhamel, O.; Moen, K. A.; Phillips, S. D.; Diestelhorst, R. M.;

Status of the University of Missouri-Columbia Research Reactor upgrade

International Nuclear Information System (INIS)

McKibben, J.C.; Edwards, C.B. Jr.; Meyer, W.A. Jr.; Kim, S.S.

1990-01-01

The University of Missouri-Columbia (MU) Research Reactor Facility staff is in the process of upgrading the operational and research capabilities of the reactor and associated facilities. The upgrades include an extended life aluminide fuel element, a power increase, improved instrumentation and control equipment, a cold neutron source, a building addition, and improved research instrumentation and equipment. These upgrades will greatly enhance the capabilities of the facility and the research programs. This paper discusses the parts of the upgrade and current status of implementation. (author)

Status of the University of Missouri-Columbia Research Reactor upgrade

Energy Technology Data Exchange (ETDEWEB)

McKibben, J C; Edwards, Jr, C B; Meyer, Jr, W A [MU Research Reactor, Columbia, MO (United States); Kim, S S [Idaho Nuclear Engineering Laboratory, Idaho Falls, ID (United States)

1990-05-01

The University of Missouri-Columbia (MU) Research Reactor Facility staff is in the process of upgrading the operational and research capabilities of the reactor and associated facilities. The upgrades include an extended life aluminide fuel element, a power increase, improved instrumentation and control equipment, a cold neutron source, a building addition, and improved research instrumentation and equipment. These upgrades will greatly enhance the capabilities of the facility and the research programs. This paper discusses the parts of the upgrade and current status of implementation. (author)

Dynamic Characteristics of Electrostatically Actuated Microbeams with Slant Crack

Directory of Open Access Journals (Sweden)

Han Zhou

2015-01-01

Full Text Available An improved model of the slant crack on a microbeam is presented. Based on fracture mechanics, the rotation coefficient for the slant crack is derived as a massless rotational spring accounting for the additional stress intensity factors generated by the orientation of the crack compared to the transverse crack. Comparisons between microbeams with a slant crack of different geometry parameters (slant angle, depth ratio, and crack position are investigated with regard to the dynamic mechanical behaviors and nonlinear response. By presenting a mathematical modeling, the effects of the slant crack and the electric actuation of an electrostatically actuated fixed-fixed microbeam on the dynamic characteristics are examined in detail. It is shown that the crack position has more significant influence on the pull-in voltage value than the slant angle or the depth ratio. Approaching the slant crack to the fixed end or enlarging the external incentives amplifies the nonlinearity of the microbeam system, while the effects of depth ratio and slant angle are dependent on the crack position. The resonance frequency and the resonance amplitude are affected as well.

A Molecularly Imprinted Polymer (MIP)-Coated Microbeam MEMS Sensor for Chemical Detection

Science.gov (United States)

2015-09-01

ARL-RP-0536 ● SEP 2015 US Army Research Laboratory A Molecularly Imprinted Polymer (MIP)- Coated Microbeam MEMS Sensor for...ARL-RP-0536 ● SEP 2015 US Army Research Laboratory A Molecularly Imprinted Polymer (MIP)- Coated Microbeam MEMS Sensor for Chemical...TITLE AND SUBTITLE A Molecularly Imprinted Polymer (MIP)-Coated Microbeam MEMS Sensor for Chemical Detection 5a. CONTRACT NUMBER 5b. GRANT NUMBER

Consequences of cytoplasmic irradiation. Studies from microbeam

International Nuclear Information System (INIS)

Zhou, Hongning; Hong, Mei; Chai, Yunfei; Hei, Tom K.

2009-01-01

The prevailing dogma for radiation biology is that genotoxic effects of ionizing radiation such as mutations and carcinogenesis are attributed mainly to direct damage to the nucleus. However, with the development of microbeam that can target precise positions inside the cells, accumulating evidences have shown that energy deposit by radiation in nuclear DNA is not required to trigger the damage, extra-nuclear or extra-cellular radiation could induce the similar biological effects as well. This review will summarize the biological responses after cytoplasm irradiated by microbeam, and the possible mechanisms involved in cytoplasmic irradiation. (author)

An ultra-thin Schottky diode as a transmission particle detector for biological microbeams

Science.gov (United States)

Harken, Andrew; Randers-Pehrson, Gerhard; Attinger, Daniel; Brenner, David J.

2013-01-01

We fabricated ultrathin metal-semiconductor Schottky diodes for use as transmission particle detectors in the biological microbeam at Columbia University’s Radiological Research Accelerator Facility (RARAF). The RARAF microbeam can deliver a precise dose of ionizing radiation in cell nuclei with sub-micron precision. To ensure an accurate delivery of charged particles, the facility currently uses a commercial charged-particle detector placed after the sample. We present here a transmission detector that will be placed between the particle accelerator and the biological specimen, allowing the irradiation of samples that would otherwise block radiation from reaching a detector behind the sample. Four detectors were fabricated with co-planar gold and aluminum electrodes thermally evaporated onto etched n-type crystalline silicon substrates, with device thicknesses ranging from 8.5 μm – 13.5 μm. We show coincident detections and pulse-height distributions of charged particles in both the transmission detector and the commercial detector above it. Detections are demonstrated at a range of operating conditions, including incoming particle type, count rate, and beam location on the detectors. The 13.5 μm detector is shown to work best to detect 2.7 MeV protons (H+), and the 8.5 μm detector is shown to work best to detect 5.4 MeV alpha particles (4He++). The development of a transmission detector enables a range of new experiments to take place at RARAF on radiation-stopping samples such as thick tissues, targets that need immersion microscopy, and integrated microfluidic devices for handling larger quantities of cells and small organisms. PMID:24058378

Microbeam facility at NIRS

International Nuclear Information System (INIS)

Sato, Yukio; Yamaguchi, Hiroshi

2000-01-01

Radiation biophysics or microdosimetry has suggested radiation effect mechanism. Full understanding of it has not yet been obtained. There are vast variety of events in physical, chemical and biological processes from at the time of irradiation to biological endpoints. Analysis of RBE-LET relation for biological endpoints like survival, mutation and transformation in cultured mammalian cells is still the leading subject to study the physical processes. The biological and repair processes have been studied phenomenologically through dose rate effect or fractionation experiment. Human genome project has accelerated biological sciences as a whole taking methodology of the molecular biology, where the mechanism is explained by molecules involved. We have thus to know entity and its (biological) function in every single process. Molecular biological approach in radiation biology has started and revealed several proteins being involved in the repair processes. Quantitative relation between phenomenological data like cell survivals and molecular processes, however, has been little known yet. A promising approach to fill this gap should be the study by microbeam, which enables us to see, for example, a deletion in chromosomal level by a single particle traverse of cell nucleus and may suggest possible molecular processes. Under this motivation we started feasibility study on installation of a microbeam port in our Tandem accelerator (5.1 MeV 4 He 2+ ). We have planned to adopt a lens focusing and a scanning system developed (by the Oxford microbeam Ltd) for the existing micro PIXE system in NIRS, which has basically achieved irradiation to a cell within a position resolution of 2 micrometer. There are two practical requirements, i.e. precise positioning and faster irradiation. These are described including research subjects planned. (author)

Light ion microbeam analysis / processing system and its improvement

International Nuclear Information System (INIS)

Koka, Masashi; Ishii, Yasuyuki; Yamada, Naoto; Ohkubo, Takeru; Kamiya, Tomihiro; Satoh, Takahiro; Kada, Wataru; Kitamura, Akane; Iwata, Yoshihiro

2016-03-01

A MeV-class light ion microbeam system has been developed for micro-analysis and micro-fabrication with high spatial resolution at 3-MV single-ended accelerator in Takasaki Ion Accelerators for Advanced Radiation Application of Takasaki Advanced Radiation Research Institute, Sector of Nuclear Science Research, Japan Atomic Energy Agency. This report describes the technical improvements for the main apparatus (the accelerator, beam-transport lines, and microbeam system), and auxiliary equipments/ parts for ion beam applications such as Particle Induced X-ray/Gamma-ray Emission (PIXE/PIGE) analysis, 3-D element distribution analysis using PIXE Computed Tomography (CT), Ion Beam Induced Luminescence (IBIL) analysis, and Proton Beam Writing with the microbeam scanning, with functional outline of these apparatus and equipments/parts. (author)

PREFACE: European Microbeam Analysis Society's 14th European Workshop on Modern Developments and Applications in Microbeam Analysis (EMAS 2015), Portorož, Slovenia, 3-7 May 2015

Science.gov (United States)

Llovet, Xavier; Matthews, Michael B.; Čeh, Miran; Langer, Enrico; Žagar, Kristina

2016-02-01

This volume of the IOP Conference Series: Materials Science and Engineering contains papers from the 14th Workshop of the European Microbeam Analysis Society (EMAS) on Modern Developments and Applications in Microbeam Analysis which took place from the 3rd to the 7th of May 2015 in the Grand Hotel Bernardin, Portorož, Slovenia. The primary aim of this series of workshops is to assess the state-of-the-art and reliability of microbeam analysis techniques. The workshops also provide a forum where students and young scientists starting out on a career in microbeam analysis can meet and discuss with the established experts. The workshops have a unique format comprising invited plenary lectures by internationally recognized experts, poster presentations by the participants and round table discussions on the key topics led by specialists in the field.This workshop was organized in collaboration with the Jožef Stefan Institute and SDM - Slovene Society for Microscopy. The technical programme included the following topics: electron probe microanalysis, STEM and EELS, materials applications, cathodoluminescence and electron backscatter diffraction (EBSD), and their applications. As at previous workshops there was also a special oral session for young scientists. The best presentation by a young scientist was awarded with an invitation to attend the 2016 Microscopy and Microanalysis meeting at Columbus, Ohio. The prize went to Shirin Kaboli, of the Department of Metals and Materials Engineering of McGill University (Montréal, Canada), for her talk entitled "Electron channelling contrast reconstruction with electron backscattered diffraction". The continuing relevance of the EMAS workshops and the high regard in which they are held internationally can be seen from the fact that 71 posters from 16 countries were on display at the meeting and that the participants came from as far away as Japan, Canada, USA, and Australia. A selection of participants with posters was invited

Improvement of the Energy Stability of the Single Ion Microbeam

International Nuclear Information System (INIS)

Zhan Furu; Qi Xuehong; Xu Mingliang; Chen Lianyun; Yu Zengliang

2008-01-01

Energy instability strongly affects the state and the beam size of the single ion microbeam. A facility based on the Generating Voltmeter was developed to improve the energy stability of the CAS-LIBB (Chinese Academy of Sciences, key laboratory of ion beam bioengineering) single ion microbeam. This paper presents the analysis of the energy instability of the single ion microbeam. A simplified theoretical model is set up to calculate the relationship between the energy instability and the beam spot size. By using this technique, the energy instability is adjusted to about 1%. Stable run-time is over 6 hours. The radius of the single ion beam is reduced by 10% compared to the previous one.

Design of the IMP microbeam irradiation system for 100 MeV/u heavy ions

International Nuclear Information System (INIS)

Sheng Lina; Song Mingtao; Zhang Xiaoqi; Yang Xiaotian; Gao Daqing; He Yuan; Zhang Bin; Liu Jie; Sun Youmei; Dang Bingrong; Lwenjian; Su Hong; Man Kaidi; Guo Yizhen; Wang Zhiguang; Zhan Wenlong

2009-01-01

A state-of-the-art high energy heavy ion microbeam irradiation system is constructed at the Institute of Modern Physics of the Chinese Academy of Sciences. This microbeam system operates in both full current intensity mode and single ion mode. It delivers a predefined number of ions to pre-selected targets for research in biology and material science. The characteristic of this microbeam system is high energy and vertical irradiation. A quadrupole focusing system, in combination with a series of slits, has been designed to optimize the spatial resolution. A symmetrically achromatic system leads the beam downwards and serves simultaneously as an energy analyzer. A high gradient quadrupole triplet finally focuses a C 6+ ion beam to 1 μm in the vacuum chamber within the energy range from 10 MeV/u to 100 MeV/u. In this paper, the IMP microbeam system is described in detail. A systematic investigation of the ion beam optics of this microbeam system is presented together with the associated aberrations. Comparison is made between the IMP microbeam system and the other existing systems to further discuss the performance of this microbeam. Then the optimized initial beam parameters are given for high resolution and high hitting efficiency. At last, the experiment platform is briefly introduced. (authors)

Vibration Characteristics of Piezoelectric Microbeams Based on the Modified Couple Stress Theory

Directory of Open Access Journals (Sweden)

R. Ansari

2014-01-01

Full Text Available The vibration behavior of piezoelectric microbeams is studied on the basis of the modified couple stress theory. The governing equations of motion and boundary conditions for the Euler-Bernoulli and Timoshenko beam models are derived using Hamilton’s principle. By the exact solution of the governing equations, an expression for natural frequencies of microbeams with simply supported boundary conditions is obtained. Numerical results for both beam models are presented and the effects of piezoelectricity and length scale parameter are illustrated. It is found that the influences of piezoelectricity and size effects are more prominent when the length of microbeams decreases. A comparison between two beam models also reveals that the Euler-Bernoulli beam model tends to overestimate the natural frequencies of microbeams as compared to its Timoshenko counterpart.

The Learning Exchange: A Shared Space for the University of British Columbia and Vancouver's Downtown Eastside Communities

Science.gov (United States)

Towle, Angela; Leahy, Kathleen

2016-01-01

The Learning Exchange was established by the University of British Columbia (UBC) in 1999 in Vancouver's Downtown Eastside (DTES). The challenge has been to create a shared space for learning exchanges between two very different communities: a research-intensive university and an inner city area most commonly depicted as a place of hopelessness.…

Development of a TOF SIMS setup at the Zagreb heavy ion microbeam facility

Science.gov (United States)

Tadić, Tonči; Bogdanović Radović, Iva; Siketić, Zdravko; Cosic, Donny Domagoj; Skukan, Natko; Jakšić, Milko; Matsuo, Jiro

2014-08-01

We describe a new Time-of-flight Secondary Ion Mass Spectrometry (TOF SIMS) setup for MeV SIMS application, which is constructed and installed at the heavy ion microbeam facility at the Ruđer Bošković Institute in Zagreb. The TOF-SIMS setup is developed for high sensitivity molecular imaging using a heavy ion microbeam that focuses ion beams (from C to I) with sub-micron resolution. Dedicated pulse processing electronics for MeV SIMS application have been developed, enabling microbeam-scanning control, incoming ion microbeam pulsing and molecular mapping. The first results showing measured MeV SIMS spectra as well as molecular maps for samples of interest are presented and discussed.

Development of a TOF SIMS setup at the Zagreb heavy ion microbeam facility

International Nuclear Information System (INIS)

Tadić, Tonči; Bogdanović Radović, Iva; Siketić, Zdravko; Cosic, Donny Domagoj; Skukan, Natko; Jakšić, Milko; Matsuo, Jiro

2014-01-01

We describe a new Time-of-flight Secondary Ion Mass Spectrometry (TOF SIMS) setup for MeV SIMS application, which is constructed and installed at the heavy ion microbeam facility at the Ruđer Bošković Institute in Zagreb. The TOF-SIMS setup is developed for high sensitivity molecular imaging using a heavy ion microbeam that focuses ion beams (from C to I) with sub-micron resolution. Dedicated pulse processing electronics for MeV SIMS application have been developed, enabling microbeam-scanning control, incoming ion microbeam pulsing and molecular mapping. The first results showing measured MeV SIMS spectra as well as molecular maps for samples of interest are presented and discussed

Alignment of dipole magnet in micro-beam line of HIRFL

International Nuclear Information System (INIS)

Wang Shaoming; Chen Wenjun; Yang Shengli; Cai Guozhu; Guo Yizhen; Zhou Guangming; Man Kaidi; Song Mingtao

2010-01-01

Microbeam irradiation facility is an experiment platform, which can reduce the beam-spot on the irradiated sample to micrometer level, and can accurately locate and count the radioactive particles. It is a powerful research tool for the irradiation material science, irradiation biology, irradiation biomedicine and micro mechanical machining. The microbeam irradiation facility requires the precise work for installation and alignment. These conditions make magnet's change for directions and positions because the location space of dipole magnets in micro-beam line of HIRFL (Heavy Ion Research Facility in Lanzhou) is very small. It is a challenge for the installation and alignment work of magnets. It was solved by transforming coordinates of benchmarks of magnets, which controlled the error of magnet setup within error tolerance range. (authors)

Electrothermally Actuated Microbeams With Varying Stiffness

KAUST Repository

Tella, Sherif Adekunle

2017-11-03

We present axially loaded clamped-guided microbeams that can be used as resonators and actuators of variable stiffness, actuation, and anchor conditions. The applied axial load is implemented by U-shaped electrothermal actuators stacked at one of the beams edges. These can be configured and wired in various ways, which serve as mechanical stiffness elements that control the operating resonance frequency of the structures and their static displacement. The experimental results have shown considerable increase in the resonance frequency and mid-point deflection of the microbeam upon changing the end conditions of the beam. These results can be promising for applications requiring large deflection and high frequency tunability, such as filters, memory devices, and switches. The experimental results are compared to multi-physics finite-element simulations showing good agreement among them.

Static Response of Microbeams due to Capillary and Electrostatic Forces

KAUST Repository

Bataineh, Ahmad M.

2016-03-07

Micro-sensors or micro-switches usually operate under the effect of electrostatic force and could face some environmental effects like humidity, which may lead to condensation underneath the beams and create strong capillary forces. Those tiny structures are principally made of microbeams that can undergo instabilities under the effect of those created huge capillary forces. In fact, during the fabrication of microbeams, there is an important step to separate the beam from its substrate (wet etching). After this step, the microstructure is dried, which may causes the onset of some droplets of water trapped underneath the beam that could bring about a huge capillary force pulling it toward its substrate. If this force is bigger than the microbeam\\'s restoring force, it will become stuck to the substrate. This paper investigates the instability scenarios of both clamped-clamped (straight and curved) and cantilever (straight and curled) microbeams under the effect of capillary and/or electrostatic forces. The reduced order modeling (ROM) based on the Galerkin procedure is used to solve the nonlinear beam equations. The non-ideal boundaries are modeled by adding springs. The volume of the fluid between the beam and the substrate underneath it is varied and the relation between the volume of the water and the stability of the beam is shown. An analysis for the factors of which should be taken in to consideration in the fabrication processes to overcome the instability due to huge capillary forces is done. Also the size of the electrode for the electrostatic force is varied to show the effect on the micro-switch stability. A variation of the pull-in voltage with some specific beam parameters and with more than one case of electrode size is shown. It is found that capillary forces have a pronounced effect on the stability of microbeams. It is also found that the pull-in length decreases as the electrode size increases. It is also shown that the pull-in voltage decreases

Origin of Knudsen forces on heated microbeams

KAUST Repository

Zhu, Taishan

2010-09-09

The presented work probes the fundamentals of Knudsen forces. Using the direct simulation Monte Carlo (DSMC) method, the flows induced by temperature inhomogeneity within a representative configuration and the Knudsen force acting on a heated microbeam are captured as functions of Knudsen number in the entire flow regime. Both flow strength and Knudsen force peak in the transition regime and negative Knudsen force absent in experimental data is observed. The mechanisms of the thermally induced flows and Knudsen forces are studied. It has been found that thermal edge flow is the main driven source for the formation of the Knudsen force on microbeams and domain configuration plays an important role in the process.

The Columbia University sub-micron charged particle beam

International Nuclear Information System (INIS)

Randers-Pehrson, Gerhard; Johnson, Gary W.; Marino, Stephen A.; Xu Yanping; Dymnikov, Alexander D.; Brenner, David J.

2009-01-01

A lens system consisting of two electrostatic quadrupole triplets has been designed and constructed at the Radiological Research Accelerator Facility (RARAF) of Columbia University. The lens system has been used to focus 6 MeV 4 He ions to a beam spot in air with a diameter of 0.8 μm. The quadrupole electrodes can withstand voltages high enough to focus 4 He ions up to 10 MeV and protons up to 5 MeV. The quadrupole triplet design is novel in that alignment is made through precise construction and the relative strengths of the quadrupoles are accomplished by the lengths of the elements, so that the magnitudes of the voltages required for focusing are nearly identical. The insulating sections between electrodes have had ion implantation to improve the voltage stability of the lens. The lens design employs Russian symmetry for the quadrupole elements.

The Columbia University Sub-micron Charged Particle Beam

Science.gov (United States)

Randers-Pehrson, Gerhard; Johnson, Gary W.; Marino, Stephen A.; Xu, Yanping; Dymnikov, Alexander D.; Brenner, David J.

2009-01-01

A lens system consisting of two electrostatic quadrupole triplets has been designed and constructed at the Radiological Research Accelerator Facility (RARAF) of Columbia University. The lens system has been used to focus 6-MeV 4He ions to a beam spot in air with a diameter of 0.8 µm. The quadrupole electrodes can withstand voltages high enough to focus 4He ions up to 10 MeV and protons up to 5 MeV. The quadrupole triplet design is novel in that alignment is made through precise construction and the relative strengths of the quadrupoles are accomplished by the lengths of the elements, so that the magnitudes of the voltages required for focusing are nearly identical. The insulating sections between electrodes have had ion implantation to improve the voltage stability of the lens. The lens design employs Russian symmetry for the quadrupole elements. PMID:20161365

Physiologically gated microbeam radiation using a field emission x-ray source array

Energy Technology Data Exchange (ETDEWEB)

Chtcheprov, Pavel, E-mail: PavelC@unc.edu, E-mail: zhou@email.unc.edu [Department of Biomedical Engineering, University of North Carolina, 152 MacNider Hall, Campus Box 7575, Chapel Hill, North Carolina 27599 (United States); Burk, Laurel; Inscoe, Christina; Ger, Rachel; Hadsell, Michael; Lu, Jianping [Department of Physics and Astronomy, University of North Carolina, Phillips Hall, CB #3255, 120 East Cameron Avenue, Chapel Hill, North Carolina 27599 (United States); Yuan, Hong [Department of Radiology, University of North Carolina, 2006 Old Clinic, CB #7510, Chapel Hill, North Carolina 27599 (United States); Zhang, Lei [Department of Applied Physical Sciences, University of North Carolina, Chapman Hall, CB#3216, Chapel Hill, North Carolina 27599 (United States); Chang, Sha [Department of Radiation Oncology, University of North Carolina, 101 Manning Drive, Chapel Hill, North Carolina 27514 and UNC Lineberger Comprehensive Cancer Center, University of North Carolina, 101 Manning Drive, Chapel Hill, North Carolina 27514 (United States); Zhou, Otto, E-mail: PavelC@unc.edu, E-mail: zhou@email.unc.edu [Department of Physics and Astronomy, University of North Carolina, Phillips Hall, CB #3255, 120 East Cameron Avenue, Chapel Hill, North Carolina 27599 and UNC Lineberger Comprehensive Cancer Center, University of North Carolina, 101 Manning Drive, Chapel Hill, North Carolina 27514 (United States)

2014-08-15

Purpose: Microbeam radiation therapy (MRT) uses narrow planes of high dose radiation beams to treat cancerous tumors. This experimental therapy method based on synchrotron radiation has been shown to spare normal tissue at up to 1000 Gy of peak entrance dose while still being effective in tumor eradication and extending the lifetime of tumor-bearing small animal models. Motion during treatment can lead to significant movement of microbeam positions resulting in broader beam width and lower peak to valley dose ratio (PVDR), which reduces the effectiveness of MRT. Recently, the authors have demonstrated the feasibility of generating microbeam radiation for small animal treatment using a carbon nanotube (CNT) x-ray source array. The purpose of this study is to incorporate physiological gating to the CNT microbeam irradiator to minimize motion-induced microbeam blurring. Methods: The CNT field emission x-ray source array with a narrow line focal track was operated at 160 kVp. The x-ray radiation was collimated to a single 280 μm wide microbeam at entrance. The microbeam beam pattern was recorded using EBT2 Gafchromic{sup ©} films. For the feasibility study, a strip of EBT2 film was attached to an oscillating mechanical phantom mimicking mouse chest respiratory motion. The servo arm was put against a pressure sensor to monitor the motion. The film was irradiated with three microbeams under gated and nongated conditions and the full width at half maximums and PVDRs were compared. An in vivo study was also performed with adult male athymic mice. The liver was chosen as the target organ for proof of concept due to its large motion during respiration compared to other organs. The mouse was immobilized in a specialized mouse bed and anesthetized using isoflurane. A pressure sensor was attached to a mouse's chest to monitor its respiration. The output signal triggered the electron extraction voltage of the field emission source such that x-ray was generated only

Ion microbeam irradiation for radiobiology and radical chemistry: status and prospect

Energy Technology Data Exchange (ETDEWEB)

Khodja, H, E-mail: hicham.khodja@cea.fr [CEA, IRAMIS, SIS2M, LEEL, 91191 Gif-sur-Yvette (France); CNRS, UMR 3299, SIS2M, LEEL, 91191 Gif-sur-Yvette (France)

2011-01-01

Ion microbeams are commonly used to study local irradiation effects in living cells, as it has been established that ion beam irradiations can lead to deleterious changes in cells that are not struck directly by the microbeam. Such changes, which take place over distances long compared to the size of the irradiation spot and for times long compared to the time of irradiation, are collectively termed radiation-induced bystander effect or RIBE. Free-radical chemistry is frequently invoked to explain the RIBE but no unified model is available at present. Ion microbeams when coupled with advanced methods for observing free radicals are the tools of choice for investigating the chemistry and biological processes governing RIBE.

Nanoscale and submicron fatigue crack growth in nickel microbeams

International Nuclear Information System (INIS)

Yang, Y.; Yao, N.; Imasogie, B.; Soboyejo, W.O.

2007-01-01

This paper presents a novel edge-notched microbeam technique for the study of short fatigue crack growth. The technique is used to study submicron and nanoscale fatigue in LIGA Ni thin films with columnar microstructures. The edge-notched microbeams were fabricated within LIGA Ni thin films, using focused ion beam (FIB) techniques. The microbeams were then cyclically deformed to failure at a stress ratio of 0.1. Different slip-band structures were observed below the nanoscale notches. Cyclic deformation resulted in the formation of primary slip bands below the notch. Subsequent crack growth then occurred by the unzipping of fatigue cracks along intersecting slip bands. The effects of the primary slip bands were idealized using dislocation-based models. These were used to estimate the intrinsic fatigue threshold and the fatigue endurance limit. The estimates from the model are shown to be consistent with experimental data from prior stress-life experiments and current/prior fatigue threshold estimates

The Impact of "Virtualization" on Independent Study Course Completion Rates: The British Columbia Open University Experiment

Science.gov (United States)

Giguere, Louis

2009-01-01

In 1997 the British Columbia Open University (BCOU) adopted a virtualization strategy based primarily on twinning off-line independent study distance education courses (textbook-based with study guide and telephone and e-mail tutor support) with alternate online versions (textbook-based with integrated conferencing and communications provided…

Live cell imaging at the Munich ion microbeam SNAKE - a status report.

Science.gov (United States)

Drexler, Guido A; Siebenwirth, Christian; Drexler, Sophie E; Girst, Stefanie; Greubel, Christoph; Dollinger, Günther; Friedl, Anna A

2015-02-18

Ion microbeams are important tools in radiobiological research. Still, the worldwide number of ion microbeam facilities where biological experiments can be performed is limited. Even fewer facilities combine ion microirradiation with live-cell imaging to allow microscopic observation of cellular response reactions starting very fast after irradiation and continuing for many hours. At SNAKE, the ion microbeam facility at the Munich 14 MV tandem accelerator, a large variety of biological experiments are performed on a regular basis. Here, recent developments and ongoing research projects at the ion microbeam SNAKE are presented with specific emphasis on live-cell imaging experiments. An overview of the technical details of the setup is given, including examples of suitable biological samples. By ion beam focusing to submicrometer beam spot size and single ion detection it is possible to target subcellular structures with defined numbers of ions. Focusing of high numbers of ions to single spots allows studying the influence of high local damage density on recruitment of damage response proteins.

Heavy ion microbeam system for study of single event effects

International Nuclear Information System (INIS)

Kamiya, Tomihiro; Utsunomiya, Nobuhiro; Minehara, Eiichi; Tanaka, Ryuichi; Ohmura, Miyoshi; Kohno, Kazuhiro; Iwamoto, Eiji.

1992-01-01

A high-energy heavy ion microbeam system has been developed and installed on a beam line of a 3 MV tandem electrostatic accelerator mainly for analysis of basic mechanism of single event upset (SEU) of semiconductor devices in spacecraft. The SEU is now the most serious problem for highly reliable spacecraft electronics system with long space mission. However, the mechanism has not been understood on the basis of microscopic process of SEU. The SEU phenomena depends not only upon hitting particles, but also upon the hit position on the microcircuit. To observe the transient charge pulse from a SEU, a single ion particle must hit exactly the desired position of the microcircuit. Such an experiment requires the microbeam spot size within 1 μm, the beam positioning accuracy within ±1 μm, and single ion hitting. The microbeam system has been designed to meet the above technical requirements. The system is equipped with two lens systems: one to control the target beam current in a wide range down to extremely low current without any change of the beam optics, and the other to focus heavy ion beams within a spot size of 1 μm. The final goal is to hit a microscopic target area with a single 15 MeV nickel ion. The beam spot size has been evaluated by Gaussian fitting of secondary electron profiles with microbeam scanning across the fine Cu mesh. The single ion detection has been also tested to generate a trigger signal for closing beam shutter to prevent further hits. This paper outlines the new microbeam system and describes methods to realize these techniques. (author)

The first interdisciplinary experiments at the IMP high energy microbeam

Energy Technology Data Exchange (ETDEWEB)

Du, Guanghua; Guo, Jinlong; Wu, Ruqun; Guo, Na; Liu, Wenjing; Ye, Fei; Sheng, Lina; Li, Qiang [Institute of Modern Physics (IMP), Chinese Academy of Sciences, Lanzhou (China); Li, Huiyun [Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen (China)

2015-04-01

The high energy beam of tens to hundred MeV/u ions possesses mm-to-cm penetration depth in materials and can be easily extracted into air without significant energy loss and beam scattering. Combination of high energy ions and microbeam technology facilitates the microprobe application to many practical studies in large scale samples. The IMP heavy ion microbeam facility has recently been integrated with microscopic positioning and targeting irradiation system. This paper introduced the first interdisciplinary experiments performed at the IMP microbeam facility using the beam of 80.5 MeV/u carbon ions. Bystander effect induction via medium transferring was not found in the micro-irradiation study using HeLa cells. The mouse irradiation experiment demonstrated that carbon irradiation of 10 Gy dose to its tuberomammillary nucleus did not impair the sleep nerve system. The fault injection attack on RSA (Rivest–Shamir–Adleman) decryption proved that the commercial field-programmable gate array chip is vulnerable in single event effect to low linear-energy-transfer carbon irradiation, and the attack can cause the leakage of RSA private key. This work demonstrates the potential of high energy microbeam in its application to biology, biomedical, radiation hardness, and information security studies.

Negative Knudsen force on heated microbeams

KAUST Repository

Zhu, Taishan; Ye, Wenjing; Zhang, Jun

2011-01-01

Knudsen force acting on a heated microbeam adjacent to a cold substrate in a rarefied gas is a mechanical force created by unbalanced thermal gradients. The measured force has its direction pointing towards the side with a lower thermal gradient

Preliminary application of tapered glass capillary microbeam in MeV-PIXE mapping of longan leaf for elemental concentration distribution analysis

Science.gov (United States)

Natyanun, S.; Unai, S.; Yu, L. D.; Tippawan, U.; Pussadee, N.

2017-09-01

This study was aimed at understanding elemental concentration distribution in local longan leaf for how the plant was affected by the environment or agricultural operation. The analysis applied the MeV-microbeam particle induced X-ray emission (PIXE) mapping technique using a home-developed tapered glass capillary microbeam system at Chiang Mai University. The microbeam was 2-MeV proton beam in 130 µm in diameter. The studying interest was in the difference in the elemental concentrations distributed between the leaf midrib and lamina areas. The micro proton beam analyzed the leaf sample across the leaf midrib edge to the leaf lamina area for total 9 data requisition spots. The resulting data were colored to form a 1D-map of the elemental concentration distribution. Seven dominant elements, Al, S, Cl, K, Ca, Sc and Fe, were identified, the first six of which were found having higher concentrations in the midrib area than in the lamina area, while the Fe concentration was in an opposite trend to that of the others.

Electron microbeam specifications for use in cell irradiation experiments

International Nuclear Information System (INIS)

Kim, E.-H.; Choi, M.-C.; Lee, D.-H.; Chang, M.; Kang, C.-S.

2003-01-01

The microbeam irradiation system was devised originally to identify the hit and unhit cells by confining the beam within the target cell. The major achievement through the microbeam experiment studies has turned out to be the discovery of the 'bystander effect'. Microbeam experiments have been performed with alpha and proton beams in major and with soft x-rays in minor. The study with electron microbeam has been deferred mainly due to the difficulty in confining the electron tracks within a single target cell. In this paper, the electron microbeam irradiation system under development in Korea is introduced in terms of the beam specifications. The KIRAMS electron microbeam irradiation system consists of an electron gun, a vacuum chamber for beam collimation into 5 μm in diameter and a biology stage. The beam characteristics in terms of current and energy spectrum of the electrons entering a target cell and its neighbor cells were investigated by Monte Carlo simulation for the electron source energies of 25, 50, 75 and 100 keV. Energy depositions in the target cell and the neighbor cells were also calculated. The beam attenuation in current and energy occurs while electrons pass through the 2 μm-thick Mylar vacuum window, 100 μm-thick air gap and the 2 μm-thick Mylar bottom of cell dish. With 25 keV electron source, 80 % of decrease in current and 30 % of decrease in average energy were estimated before entering the target cell. With 75 keV electron source, on the other hand, 55 % of decrease in current and less than 1 % of decrease in average energy were estimated. Average dose per single collimated electron emission was 0.067 cGy to the target cell nucleus of 5 μm in diameter and 0.030 cGy to the cytoplasm of 2.5 μm in thickness with 25 keV electron source while they were 0.15 cGy and 0.019 cGy, respectively, with 75 keV electron source. The multiple scattering of electrons resulted in energy deposition in the neighbor cells as well. Dose to the first

Active mems microbeam device for gas detection

KAUST Repository

Bouchaala, Adam M.; Jaber, Nizar; Younis, Mohammad I.

2017-01-01

Sensors and active switches for applications in gas detection and other fields are described. The devices are based on the softening and hardening nonlinear response behaviors of microelectromechanical systems (MEMS) clamped-clamped microbeams

Provincial Coordination and Inter-Institutional Collaboration in British Columbia's College, University College and Institute System. Monograph Series.

Science.gov (United States)

Gaber, Devron

This document addresses a study that aimed to better understand the historical development of British Columbia community college, university college, and institute system with special attention given to recent changes in inter-institutional collaboration in relation to provincial coordination. The study also addresses centralization and…

Semiconductor analysis with a channeled helium microbeam

International Nuclear Information System (INIS)

Ingarfield, S.A.; McKenzie, C.D.; Short, K.T.; Williams, J.S.

1981-01-01

This paper describes the use of a channeled helium microbeam for analysis of damage and dopant distributions in semiconductors. Practical difficulties and potential problems associated with the channeling of microbeams in semiconductors have been examined. In particular, the following factors have been characterised: i) the effect of both convergence of focused beam and beam scanning on the quality of channeling; ii) damage produced by the probe ions; and iii) local beam heating effects arising from high current densities. Acceptable channeling has been obtained (minimum yield approaching 4%) under a variety of focusing and scanning conditions which are suitable for analysis of device structures. The capabilities of the technique are demonstrated by monitoring variations in local damage and impurity depth distributions across a narrow (<2mm) region of an ion implanted silicon wafer

X-ray microbeams: Tumor therapy and central nervous system research

International Nuclear Information System (INIS)

Dilmanian, F.A.; Qu, Y.; Liu, S.; Cool, C.D.; Gilbert, J.; Hainfeld, J.F.; Kruse, C.A.; Laterra, J.; Lenihan, D.; Nawrocky, M.M.; Pappas, G.; Sze, C.-I.; Yuasa, T.; Zhong, N.; Zhong, Z.; McDonald, J.W.

2005-01-01

Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology

Other applications of ion microbeams

International Nuclear Information System (INIS)

Cookson, J.A.

1987-01-01

The paper concerns the analytical and non-analytical applications of ion microbeams. The analytical applications considered include:-fusion research, environmental studies, ion implantations and criminology, and each is briefly discussed. Non-analytical applications in which nuclear microprobes have been used include:-thickness and uniformity measurements, energy loss radiography, channelling contrast, tomography, topography, ion implantation, and detector testing, and these are also discussed. (UK)

Elemental analysis techniques using proton microbeam

International Nuclear Information System (INIS)

Sakai, Takuro; Oikawa, Masakazu; Sato, Takahiro

2005-01-01

Proton microbeam is a powerful tool for two-dimensional elemental analysis. The analysis is based on Particle Induced X-ray Emission (PIXE) and Particle Induced Gamma-ray Emission (PIGE) techniques. The paper outlines the principles and instruments, and describes the dental application has been done in JAERI Takasaki. (author)

Study of transient current induced by heavy-ion microbeams in Si and GaAs

Energy Technology Data Exchange (ETDEWEB)

Hirao, Toshio; Nashiyama, Isamu; Kamiya, Tomihiro; Suda, Tamotu [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

1997-03-01

Heavy-ion microbeams were applied to the study of mechanism of single event upset (SEU). Transient current induced in p{sup +}n junction diodes by strike of heavy ion microbeam were measured by using a high-speed digitizing sampling system. (author)

Multifrequency Excitation of a Clamped-Clamped Microbeam

KAUST Repository

Jaber, Nizar; Ramini, Abdallah; Younis, Mohammad I.

2016-01-01

. These microbeams are fabricated using polyimide as structural layer coated with nickel form top and chromium and gold layers from bottom. We demonstrate the excitation of additive and subtractive type resonance. We show that by properly tuning the frequency

Earth Institute at Columbia University ADVANCE Program: Addressing Needs for Women in Earth and Environmental Sciences

Science.gov (United States)

Bell, R. E.; Cane, M.; Mutter, J.; Miller, R.; Pfirman, S.; Laird, J.

2004-12-01

The Earth Institute has received a major NSF ADVANCE grant targeted at increasing the participation and advancement of women scientists and engineers in the Academy through institutional transformation. The Earth Institute at Columbia University includes 9 research institutes including Lamont-Doherty Earth Observatory, Center for Environmental Research and Conservation (CERC), Center for International Earth Science Information Network (CIESIN), International Research Institute (IRI) for Climate Prediction, Earth Engineering Center, NASA-Goddard Institute for Space Studies, Center for Risks and Hazards, Center for Globalization and Sustainable Development, and Center for Global Health and Economic Development and six academic departments including Ecology, Evolution and Environmental Biology (E3B, School of Arts and Sciences), Earth and Environmental Engineering (DEEE, School of Engineering and Applied Sciences), Department of Environmental Health (School of Public Health), Department of Earth and Environmental Sciences (DEES, School of Arts and Sciences), Department of International and Public Affairs (School of International and Policy Affairs), and Barnard College Department of Environmental Science. The Earth Institute at Columbia University's ADVANCE program is based both on a study of the status of women at Columbia and research on the progression of women in science elsewhere. The five major targets of the Columbia ADVANCE program are to (1) change the demographics of the faculty through intelligent hiring practices, (2) provide support to women scientists through difficult life transitions including elder care and adoption or birth of a child, (3) enhance mentoring and networking opportunities, (4) implement transparent promotion procedures and policies, and (5) conduct an institutional self study. The Earth Institute ADVANCE program is unique in that it addresses issues that tend to manifest themselves in the earth and environmental fields, such as extended

Origin of Knudsen forces on heated microbeams

KAUST Repository

Zhu, Taishan; Ye, Wenjing

2010-01-01

microbeam are captured as functions of Knudsen number in the entire flow regime. Both flow strength and Knudsen force peak in the transition regime and negative Knudsen force absent in experimental data is observed. The mechanisms of the thermally induced

Multifrequency excitation of a clamped–clamped microbeam: Analytical and experimental investigation

KAUST Repository

Jaber, Nizar

2016-03-14

Using partial electrodes and a multifrequency electrical source, we present a large-bandwidth, large-amplitude clamped–clamped microbeam resonator excited near the higher order modes of vibration. We analytically and experimentally investigate the nonlinear dynamics of the microbeam under a two-source harmonic excitation. The first-frequency source is swept around the first three modes of vibration, whereas the second source frequency remains fixed. New additive and subtractive resonances are demonstrated. We illustrated that by properly tuning the frequency and amplitude of the excitation force, the frequency bandwidth of the resonator is controlled. The microbeam is fabricated using polyimide as a structural layer coated with nickel from the top and chromium and gold layers from the bottom. Using the Galerkin method, a reduced order model is derived to simulate the static and dynamic response of the device. A good agreement between the theoretical and experimental data are reported.

Multifrequency excitation of a clamped–clamped microbeam: Analytical and experimental investigation

KAUST Repository

Jaber, Nizar; Ramini, Abdallah; Younis, Mohammad I.

2016-01-01

Using partial electrodes and a multifrequency electrical source, we present a large-bandwidth, large-amplitude clamped–clamped microbeam resonator excited near the higher order modes of vibration. We analytically and experimentally investigate the nonlinear dynamics of the microbeam under a two-source harmonic excitation. The first-frequency source is swept around the first three modes of vibration, whereas the second source frequency remains fixed. New additive and subtractive resonances are demonstrated. We illustrated that by properly tuning the frequency and amplitude of the excitation force, the frequency bandwidth of the resonator is controlled. The microbeam is fabricated using polyimide as a structural layer coated with nickel from the top and chromium and gold layers from the bottom. Using the Galerkin method, a reduced order model is derived to simulate the static and dynamic response of the device. A good agreement between the theoretical and experimental data are reported.

The application of microbeam in the research on radiation-induced bystander effects

International Nuclear Information System (INIS)

Xiong Jie; Han Ling

2002-01-01

There has been more and more attention to the phenomenon known as radiation-induced bystander effects, which will have a tremendous effect on the research in low -dose radiation biological effects. However, due to the stochastic nature of energy deposition and the random position of tracts, direct evidence for bystander effects and exact results of single particle interacts with a cell cannot be provided by using conventional broad-field irradiation. The availability of microbeam, especially the single particle microbeam in the world, whereby individual cells or precise location of cells can be irradiated with either a single or an exact number of particles provides a useful tool for the research on radiation-induced bystander effects. The author describes the radiation -induced bystander effect and the application of microbeam in the research on it

Development of an intermediate energy heavy-ion micro-beam irradiation system

International Nuclear Information System (INIS)

Song Mingtao; Wang Zhiguang; He Yuan; Gao Daqing; Yang Xiaotian; Liu Jie; Su Hong; Man Kaidi; Sheng Li'na

2008-01-01

The micro-beam irradiation system, which focuses the beam down the micron order and precisely delivers a predefined number of ions to a predefined spot of micron order, is a powerful tool for radio-biology, radio-biomedicine and micromachining. The Institute of Modern Physics of Chinese Academy of Sciences is developing a heavy-ion micro-beam irradiation system up to intermediate energy. Based on the intermediate and low energy beam provided by Heavy Ion Research Facility of Lanzhou, the micro-beam system takes the form of the magnetic focusing. The heavy-ion beam is conducted to the basement by a symmetrical achromatic system consisting of two vertical bending magnets and a quadrupole in between. Then a beam spot of micron order is formed by magnetic triplet quadrupole of very high gradient. The sample can be irradiated either in vacuum or in the air. This system will be the first opening platform capable of providing heavy ion micro-beam, ranging from low (10 MeV/u) to intermediate energy (100 MeV/u), for irradiation experiment with positioning and counting accuracy. Target material may be biology cell, tissue or other non-biological materials. It will be a help for unveiling the essence of heavy-ion interaction with matter and also a new means for exploring the application of heavy-ion irradiation. (authors)

Dynamic response of an electrostatically actuated microbeam to drop-table test

International Nuclear Information System (INIS)

Ouakad, Hassen M; Younis, Mohammad I; Alsaleem, Fadi

2012-01-01

In this paper, we present a theoretical and experimental investigation into the dynamic response of an electrostatically actuated microbeam when subjected to drop-table test. For the theoretical part, a reduced-order model based on an Euler–Bernoulli beam model is utilized. The model accounts for the electrostatic bias on the microbeam and the shock pulse of the drop-table test. Simulation results are presented showing the combined effect of electrostatic force and mechanical shock in triggering early pull-in instability of the cantilever microbeams. The analytical simulation results are validated by finite-element results for the static response. Dynamic pull-in threshold as a function of the mechanical shock amplitude is shown over a wide range of shock spanning hundreds of thousands of g up to zero g. For the experimental part, a micromachined cantilever beam made of gold of length 50 µm is subjected to drop-table tests while being biased by electrostatic loads. Several experimental data are shown demonstrating the phenomenon of collapse due to the combined shock and electrostatic forces. It is also demonstrated that by biasing short and too stiff microbeams with electrostatic voltages, their stiffness is weakened. This lowers their threshold of collapse considerably to the range of acceleration that enables testing them with in-house shock testing equipments, such as drop-table tests. (paper)

Multifrequency Excitation of a Clamped-Clamped Microbeam

KAUST Repository

Jaber, Nizar R.

2016-01-20

We present analytical and experimental investigation of an electrically actuated clamped-clamped microbeam under a twosource harmonic excitation. The first frequency is swept around the first mode of vibration where the second one is fixed. These microbeams are fabricated using polyimide as structural layer coated with nickel form top and chromium and gold layers from bottom. We demonstrate the excitation of additive and subtractive type resonance. We show that by properly tuning the frequency and the amplitude of the excitation force, the frequency bandwidth of the resonator is increased. Theoretically, we solved the eigenvalue problem for different axial forces to find the natural frequencies ratio that match the experimental values. Using Galerkin method, a reduced order model is derived to simulate the static and dynamic response of the device where using three symmetric mode shapes provided a good agreement with experimental data. © Copyright 2015 by ASME.

WE-AB-BRB-12: Nanoscintillator Fiber-Optic Detector System for Microbeam Radiation Therapy Dosimetry

Energy Technology Data Exchange (ETDEWEB)

Rivera, J [University of North Carolina and North Carolina State University, Chapel Hill, NC (United States); Dooley, J; Chang, S [University of North Carolina School of Medicine, Chapel Hill, NC (United States); Belley, M; Yoshizumi, T [Duke University Medical Center, Durham, NC (United States); Stanton, I; Langloss, B; Therien, M [Duke University, Durham, NC (United States)

2015-06-15

Purpose: Microbeam Radiation Therapy (MRT) is an experimental radiation therapy that has demonstrated a higher therapeutic ratio than conventional radiation therapy in animal studies. There are several roadblocks in translating the promising treatment technology to clinical application, one of which is the lack of a real-time, high-resolution dosimeter. Current clinical radiation detectors have poor spatial resolution and, as such, are unsuitable for measuring microbeams with submillimeter-scale widths. Although GafChromic film has high spatial resolution, it lacks the real-time dosimetry capability necessary for MRT preclinical research and potential clinical use. In this work we have demonstrated the feasibility of using a nanoscintillator fiber-optic detector (nanoFOD) system for real-time MRT dosimetry. Methods: A microplanar beam array is generated using a x-ray research irradiator and a custom-made, microbeam-forming collimator. The newest generation nanoFOD has an effective size of 70 µm in the measurement direction and was calibrated against a kV ion chamber (RadCal Accu-Pro) in open field geometry. We have written a computer script that performs automatic data collection with immediate background subtraction. A computer-controlled detector positioning stage is used to precisely measure the microbeam peak dose and beam profile by translating the stage during data collection. We test the new generation nanoFOD system, with increased active scintillation volume, against the previous generation system. Both raw and processed data are time-stamped and recorded to enable future post-processing. Results: The real-time microbeam dosimetry system worked as expected. The new generation dosimeter has approximately double the active volume compared to the previous generation resulting in over 900% increase in signal. The active volume of the dosimeter still provided the spatial resolution that meets the Nyquist criterion for our microbeam widths. Conclusion: We have

Parameter identification of an electrically actuated imperfect microbeam

KAUST Repository

Ruzziconi, Laura; Younis, Mohammad I.; Lenci, Stefano

2013-01-01

In this study we consider a microelectromechanical system (MEMS) and focus on extracting analytically the model parameters that describe its non-linear dynamic features accurately. The device consists of a clamped-clamped polysilicon microbeam

History of Cardiothoracic Surgery at Columbia University: A Century at the Vanguard of Clinical Care, Education, and Innovation.

Science.gov (United States)

Argenziano, Michael; Smith, Craig R; Spotnitz, Henry M; Steinglass, Kenneth M; Bacha, Emile

2016-01-01

The Columbia University Cardiothoracic Surgery Program dates back to the earliest days of the specialty itself, when the first pioneers ventured into the chest, and eventually the heart, to treat diseases previously believed to be beyond the reach of medicine. This spirit of innovation, creativity, and vision has grown over the ensuing century and has driven the development of advances that have defined the specialty and saved countless lives. From novel techniques for the repair of complex congenital cardiac defects and acquired cardiovascular diseases, to comprehensive management of lung and esophageal maladies, and to the marvel of minimally invasive and percutaneous interventions, the march of progress has never been stronger, more dramatic, or more consequential that it is at Columbia today. Fueled by people who -- as descendants of those early pioneers -- have been raised in the "Columbia culture," the commitment to innovation and education has never been greater. Copyright © 2016. Published by Elsevier Inc.

Residual stress measurement method in MEMS microbeams using frequency shift data

International Nuclear Information System (INIS)

Somà, Aurelio; Ballestra, Alberto

2009-01-01

The dynamical behaviour of a set of gold microbeams affected by residual stress has been studied. Experimental frequency shift curves were obtained by increasing the dc voltage applied to the specimens. Comparison with different analytical and numerical models has been carried out in order to identify both analytical and finite element models in the presence of residual stress. Residual strain and stress, due to the fabrication process, have been widely reported in the literature in both out-of-plane microcantilevers and clamped–clamped microbeams by using mainly the value of pull-in voltage and static deflection data. In the case of a microcantilever, an accurate modelling includes the effect of the initial curvature due to microfabrication. In double-clamped microbeams, a pre-load applied by tensile stress is considered. A good correspondence is pointed out between measurements and numerical models so that the residual stress effect can be evaluated for different geometrical configurations

Archive of Geosample Data and Information from the Columbia University Lamont-Doherty Earth Observatory (LDEO) Lamont-Doherty Core Repository (LDCR)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Lamont-Doherty Core Repository (LDCR), operated by the Lamont-Doherty Earth Observatory (LDEO) of Columbia University is a partner in the Index to Marine and...

Synchrotron x-ray microbeam characteristics for x-ray fluorescence analysis

International Nuclear Information System (INIS)

Iida, Atsuo; Noma, Takashi

1995-01-01

X-ray fluorescence analysis using a synchrotron x-ray microprobe has become an indispensable technique for non-destructive micro-analysis. One of the most important parameters that characterize the x-ray microbeam system for x-ray fluorescence analysis is the beam size. For practical analysis, however, the photon flux, the energy resolution and the available energy range are also crucial. Three types of x-ray microbeam systems, including monochromatic and continuum excitation systems, were compared with reference to the sensitivity, the minimum detection limit and the applicability to various types of x-ray spectroscopic analysis. 16 refs., 5 figs

Advances in radiobiological studies using a microbeam

International Nuclear Information System (INIS)

Hei, Tom K.; Brenner, David J.; Geard, Charles R.; Ballas, Leslie K.

2009-01-01

Recent developments in microbeam technology have made drastic improvements in particle delivery, focusing, image processing and precision to allow for rapid advances in our knowledge in radiation biology. The unequivocal demonstration that targeted cytoplasmic irradiation results in mutations in the nuclei of hit cells and the presence of non-targeted effects, all made possible using a charged particle microbeam, results in a paradigm shift in our basic understanding of the target theory and other radiation-induced low dose effects. The demonstration of a bystander effect in 3D human tissue and whole organisms have shown the potential relevance of the non-targeted response in human health. The demonstration of delayed mutations in the progeny of bystander cells suggest that genomic instability induced following ionizing radiation exposure is not dependent on direct damage to cell nucleus. The identification of specific signaling pathways provides mechanistic insight on the nature of the bystander process. (author)

Live cell imaging at the Munich ion microbeam SNAKE – a status report

International Nuclear Information System (INIS)

Drexler, Guido A; Siebenwirth, Christian; Drexler, Sophie E; Girst, Stefanie; Greubel, Christoph; Dollinger, Günther; Friedl, Anna A

2015-01-01

Ion microbeams are important tools in radiobiological research. Still, the worldwide number of ion microbeam facilities where biological experiments can be performed is limited. Even fewer facilities combine ion microirradiation with live-cell imaging to allow microscopic observation of cellular response reactions starting very fast after irradiation and continuing for many hours. At SNAKE, the ion microbeam facility at the Munich 14 MV tandem accelerator, a large variety of biological experiments are performed on a regular basis. Here, recent developments and ongoing research projects at the ion microbeam SNAKE are presented with specific emphasis on live-cell imaging experiments. An overview of the technical details of the setup is given, including examples of suitable biological samples. By ion beam focusing to submicrometer beam spot size and single ion detection it is possible to target subcellular structures with defined numbers of ions. Focusing of high numbers of ions to single spots allows studying the influence of high local damage density on recruitment of damage response proteins. The online version of this article (doi:10.1186/s13014-015-0350-7) contains supplementary material, which is available to authorized users

Dynamics of a clamped–clamped microbeam resonator considering fabrication imperfections

KAUST Repository

Bataineh, Ahmad M.

2014-10-18

We present an investigation into the static and dynamic behavior of an electrostatically actuated clamped–clamped polysilicon microbeam resonator accounting for its fabrication imperfections, which are commonly encountered in similar microstructures. These are mainly because of the initial deformation of the beam due to stress gradient and its flexible anchors. First, we show experimental data of the microbeam when driven electrically by varying the amplitude and frequency of the voltage loads. The results reveal several interesting nonlinear phenomena of jumps, hysteresis, and softening behaviors. Theoretical investigation is then conducted to model the microbeam, and hence, interpret the experimental data. We solve the Eigen value problem governing the natural frequencies analytically. We then utilize a Galerkin-based procedure to derive a reduced order model, which is then used to simulate both the static and dynamic responses. To achieve good matching between theory and experiment, we show that the exact profile of the deformed beam needs to be utilized in the reduced order model, as measured from the optical profiler, combined with a shooting technique simulation, which is capable of tracing the resonant frequency branches under very-low damping conditions.

Channeling-based collimators for generation of microbeams produced by silicon micromachining technology

International Nuclear Information System (INIS)

Guidi, V.; Antonini, A.; Milan, E.; Ronzoni, A.; Martinelli, G.; Biryukov, V.M.; Chesnokov, Yu.A.

2006-01-01

The growing interest on micro-beams in recent years and the combined development of channeling technology in high-energy physics have opened the way to new concepts for micro-beams devices. Silicon micromachining technology is here applied to manufacture micro-collimators in inexpensive and feasible ways. Both dry and wet etchings can be employed for the purpose, though the latter technique appears to be cheaper and easier. Two designs for micro-collimator devices have been considered and preliminary samples have been produced accordingly

Aboriginal Business Capacity Building Programs in the Central Interior of British Columbia: A Collaborative Project between the University and Communities

Science.gov (United States)

Kunkel, Titi; Schorcht, Blanca; Brazzoni, Randall

2011-01-01

Aboriginal communities in Canada are typically marginalized, have very low employment participation rates, and have limited economic infrastructure. The downturn in global economies further marginalized these communities. The University of Northern British Columbia's (UNBC) Continuing Studies department piloted an Aboriginal and Small Business…

Converse flexoelectric effect in comb electrode piezoelectric microbeam

Energy Technology Data Exchange (ETDEWEB)

Shen, Zhiyuan, E-mail: shenyuan675603@gmail.com [School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore (Singapore); Chen, Wei [Microelectronics Centre, School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore (Singapore)

2012-04-09

We demonstrate the converse flexoelectric effect in a lead zirconate titanate microbeam. The fringe electric field of a comb electrode induces converse flexoelectric responses in uniformly poled and depoled beams. The simulated electric field distribution shows that bending of the beam is induced by piezoelectric and μ{sub 11}, μ{sub 12} flexoelectric coefficients. Simulations indicate that piezoelectric displacement occurs in different directions in the two opposite poled samples while flexoelectric displacement remains the same. This finding is verified by the displacement measurement results. -- Highlights: ► We demonstrate the converse flexoelectric effect in a PZT microbeam. ► Beams with upward and downward poling states are fabricated by MEMS technique. ► Converse flexoelectric deformation is induced by the fringe field. ► Electric field distribution is calculated by finite element analysis. ► The simulation results are verified by impedance and displacement measurements.

The accident of overexposure at the University hospital center of Toulouse. Expertise report n.1. Checking of experimental protocols of micro-beams calibration before and after dysfunction correction

International Nuclear Information System (INIS)

2007-01-01

The regional center of stereotaxic radiosurgery of the University hospital center of Toulouse is equipped since april 2006 of a Novalis accelerator (Brainlab) devoted to the intra-skull stereotaxic radiosurgery. In april 2007, during an intercomparison of dosimetry computer files coming from different sites, the Brainlab society finds an anomaly in the files. The analysis made by the society concludes to to the use of an inappropriate detector for the measurement of a dosimetry parameter during the initial calibration of the accelerator. following this error, 145 patients (on the 172 treated by the service in question) suffer the consequences of an overdose whom importance is variable according the cases. The I.R.S.N. in charge of an expertise about the protocols of calibration of micro-beams before and after the correction of the dysfunction, took up with the search of the technical causes of the dysfunction. This report presents successively: the documents base on which is founded the expertise; the material of dosimetry and quality control necessary to the initial calibration of the device and to its follow-up; the formula made at the accelerator commissioning; the calibration of micro-beams in the two configurations that allows the device (micro-multi-knives and conic collimator) and the definition of parameters of the software of treatment planning; the maintenance and quality control implemented in the frame of its clinical use. (N.C.)

The Dynamics of a Doubly Clamped Microbeam Near the Primary Resonance: Experimental and Analytical Investigation

KAUST Repository

Masri, Karim M.

2016-01-20

We present experimental and analytical investigation of the dynamics of a doubly clamped microbeam near its primary resonance. The microbeam is excited electrostatically by an electrode on the first half of the beam. These microbeams are fabricated using polyimide as structural layer coated with nickel from top and chromium and gold layers from bottom. A noise signal is applied to experimentally detect the natural frequencies. Then, frequency sweep tests are generated for various values of DC bias revealing hardening, transition, and softening behavior of the microbeam. We report for the first time the transition from lower stable state, to unstable state, and then to large stable state experimentally. A multi-mode Galerkin method is used to develop a reduced order model (ROM) of the beam. Shooting method is used to find the periodic motion and is utilized to generate frequency response curves. The curves show good agreement with the experimental results with hardening behavior at lower DC voltage then softening at higher voltage loads and dynamic pull-in. © Copyright 2015 by ASME.

Study of squeeze film damping in a micro-beam resonator based on micro-polar theory

Directory of Open Access Journals (Sweden)

Mina Ghanbari

Full Text Available In this paper, squeeze film damping in a micro-beam resonator based on micro-polar theory has been investigated. The proposed model for this study consists of a clamped-clamped micro-beam bounded between two fixed layers. The gap between the micro-beam and layers is filled with air. As fluid behaves differently in micro scale than macro, the micro-scale fluid field in the gap has been modeled based on micro-polar theory. Equation of motion governing transverse deflection of the micro- beam based on modified couple stress theory and also non-linear Reynolds equation of the fluid field based on micropolar theory have been non-dimensionalized, linearized and solved simultaneously in order to calculate the quality factor of the resonator. The effect of micropolar parameters of air on the quality factor has been investigated. The quality factor of the of the micro-beam resonator for different values of non-dimensionalized length scale of the beam, squeeze number and also non-dimensionalized pressure has been calculated and compared to the obtained values of quality factor based on classical theory.

Evaluating the peak-to-valley dose ratio of synchrotron microbeams using PRESAGE fluorescence

International Nuclear Information System (INIS)

Annabell, N.; Yagi, N.; Umetani, K.; Wong, C.; Geso, M.

2012-01-01

The peak-to-valley dose ratio of a microbeam array can be measured by fluorescence of PRESAGE dosimeters. Peak-to-valley dose ratios are calculated using this new technique and also by EBT2 film. Synchrotron-generated microbeam radiotherapy holds great promise for future treatment, but the high dose gradients present conventional dosimetry with a challenge. Measuring the important peak-to-valley dose ratio (PVDR) of a microbeam-collimated synchrotron source requires both a dosimeter and an analysis method capable of exceptional spatial resolution. The PVDR is of great interest since it is the limiting factor for potential application of the microbeam radiation therapy technique clinically for its tissue-sparing properties (i.e. the valley dose should be below the tolerance of normal tissue). In this work a new method of measuring the dose response of PRESAGE dosimeters is introduced using the fluorescence from a 638 nm laser on a confocal laser-scanning microscope. This fluorescent microscopy method produces dosimetry data at a pixel size as low as 78 nm, giving a much better spatial resolution than optical computed tomography, which is normally used for scanning PRESAGE dosimeters. Using this technique the PVDR of the BL28B2 microbeam at the SPring-8 synchrotron in Japan is estimated to be approximately 52:1 at a depth of 2.5 mm. The PVDR was also estimated with EBT2 GAFchromic films as 30.5:1 at the surface in order to compare the PRESAGE fluorescent results with a more established dosimetry system. This estimation is in good agreement with previously measured ratios using other dosimeters and Monte Carlo simulations. This means that it is possible to use PRESAGE dosimeters with confocal microscopy for the determination of PVDR

Application of microbeam in bio-science and life science. Biological effects induced in bystander cells by particle microbeams

International Nuclear Information System (INIS)

Suzuki, Masao

2006-01-01

Biological events occurring in cells directly hit by radiation appear in bystander cells nearby not hit directly, which is called the bystander effect. This review describes the events and mechanisms of biological bystander effect yielded by the low-dose radiation including the microbeam. Bystander effects, particularly by charged particle beams, have been studied by two representative approaches by α-ray from plutonium (stochastic irradiation) and by particle microbeams (targeted irradiation), where a bystander effect like chromosome aberrations is shown to occur by communication between irradiated and non-irradiated cells through gap junction. Bystander effects that do not require the cell contact also occur in the irradiated cell-conditioned medium (ICCM), where, not only the short-life radicals like reactive oxygen species and NO, but also more long-life factors participate. Authors have shown the presence of such bystander-inducing factors in ICCM, producing the aberrations even 48 hr after irradiation of either low or high linear energy transfer (LET) radiation. Bystander effects can be important from the aspect of risk assessments of radiation in the terrestrial/spatial environment involving aircraft as well as in cancer therapy by low-dose heavy particle beams. (T.I)

Performances of synchrotron radiation microbeam focused by monolithic half focusing polycapillary X-ray lens

International Nuclear Information System (INIS)

Sun Tianxi; Liu Zhiguo; He Bo; Wei Shiqiang; Xie Yaning; Liu Tao; Hu Tiandou; Ding Xunliang

2007-01-01

A monolithic half focusing polycapillary X-ray lens (MHFPXRL) composed of 289,000 capillaries is used to produce a synchrotron radiation microbeam. The energy dependence of the output focal distance, focal spot size, transmission efficiency, vertical beam position, and gain in flux density of this microbeam is studied in detail. There is a slight change in the output focal distance of the MHFPXRL when the X-ray energies change

Size-dependent pull-in instability of electrostatically actuated microbeam-based MEMS

International Nuclear Information System (INIS)

Wang, Binglei; Zhou, Shenjie; Zhao, Junfeng; Chen, Xi

2011-01-01

We present a size-dependent model for electrostatically actuated microbeam-based MEMS using strain gradient elasticity theory. The normalized pull-in voltage is shown to increase nonlinearly with the decrease of the beam height, and the size effect becomes prominent if the beam thickness is on the order of microns or smaller (i.e. when the beam dimension is comparable to the material length scale parameter). Very good agreement is found between the present model and available experimental data. The study may be helpful to characterize the mechanical properties of small size MEMS, or guide the design of microbeam-based devices for a wide range of potential applications. (technical note)

Microbeams, microdosimetry and specific dose

International Nuclear Information System (INIS)

Randers-Pehrson, H.

2002-01-01

Dose and its usefulness as a single parameter to describe the amount of radiation absorbed are well established for most situations. The conditions where the concept of dose starts to break down are well known, mostly from the study of microdosimetry. For low doses of high LET radiation it is noted that the process of taking the limiting value of the energy absorbed within a test volume divided by the mass within that volume yields either zero or a relatively large value. The problem is further exacerbated with microbeam irradiations where the uniformity of the energy deposition is experimentally manipulated on the spatial scale of cells being irradiated. Booz introduced a quantity to deal with these problems: the unfortunately named 'mean specific energy in affected volumes'. This quantity multiplied by the probability that a test volume has received an energy deposit is equal to dose (in situations where dose can be defined). I propose that Booz's quantity be renamed 'specific dose', that is the mean energy deposited divided by the mass within a specified volume. If we believe for instance that the nucleus of a cell is the critical volume for biological effects, we can refer to the nuclear specific dose. A microbeam experiment wherein 10 per cent of the cell nuclei were targeted with 10 alpha particles would be described as delivering a nuclear specific dose of 1.6 Gy to 10 per cent of the population. (author)

On the Nonlinear Dynamics of a Doubly Clamped Microbeam near Primary Resonance

KAUST Repository

Jaber, Nizar; Masri, Karim M.; Younis, Mohammad I.

2017-01-01

This work aims to investigate theoretically and experimentally various nonlinear dynamic behaviors of a doubly clamped microbeam near its primary resonance. Mainly, we investigate the transition behavior from hardening, mixed, and then softening behavior. We show in a single frequency-response curve, under a constant voltage load, the transition from hardening to softening behavior demonstrating the dominance of the quadratic electrostatic nonlinearity over the cubic geometric nonlinearity of the beam as the motion amplitudes becomes large, which may lead eventually to dynamic pull-in. The microbeam is fabricated using polyimide as a structural layer coated with nickel from top and chromium and gold layers from the bottom. Frequency sweep tests are conducted for different values of DC bias revealing hardening, mixed, and softening behavior of the microbeam. A multi-mode Galerkin model combined with a shooting technique are implemented to generate the frequency response curves and to analyze the stability of the periodic motions using the Floquet theory. The simulated curves show good agreement with the experimental data.

On the Nonlinear Dynamics of a Doubly Clamped Microbeam near Primary Resonance

KAUST Repository

Jaber, Nizar

2017-04-07

This work aims to investigate theoretically and experimentally various nonlinear dynamic behaviors of a doubly clamped microbeam near its primary resonance. Mainly, we investigate the transition behavior from hardening, mixed, and then softening behavior. We show in a single frequency-response curve, under a constant voltage load, the transition from hardening to softening behavior demonstrating the dominance of the quadratic electrostatic nonlinearity over the cubic geometric nonlinearity of the beam as the motion amplitudes becomes large, which may lead eventually to dynamic pull-in. The microbeam is fabricated using polyimide as a structural layer coated with nickel from top and chromium and gold layers from the bottom. Frequency sweep tests are conducted for different values of DC bias revealing hardening, mixed, and softening behavior of the microbeam. A multi-mode Galerkin model combined with a shooting technique are implemented to generate the frequency response curves and to analyze the stability of the periodic motions using the Floquet theory. The simulated curves show good agreement with the experimental data.

MPH education for the 21st century: design of Columbia University's new public health curriculum.

Science.gov (United States)

Begg, Melissa D; Galea, Sandro; Bayer, Ronald; Walker, Julia R; Fried, Linda P

2014-01-01

Because public health challenges are changing rapidly, over the past 3 years, we have turned a critical eye to the master of public health program at the Columbia University Mailman School of Public Health. Under a process dubbed "curriculum renewal," we engaged more than 170 faculty, staff, and students (and hundreds of alumni and employers of our graduates) in an initiative to develop a completely new design for master of public health education that launched in fall 2012. We have described its design and structure and presented some preliminary evaluation data.

Microbeam high-resolution diffraction and x-ray standing wave methods applied to semiconductor structures

International Nuclear Information System (INIS)

Kazimirov, A; Bilderback, D H; Huang, R; Sirenko, A; Ougazzaden, A

2004-01-01

A new approach to conditioning x-ray microbeams for high angular resolution x-ray diffraction and scattering techniques is introduced. We combined focusing optics (one-bounce imaging capillary) and post-focusing collimating optics (miniature Si(004) channel-cut crystal) to generate an x-ray microbeam with a size of 10 μm and ultimate angular resolution of 14 μrad. The microbeam was used to analyse the strain in sub-micron thick InGaAsP epitaxial layers grown on an InP(100) substrate by the selective area growth technique in narrow openings between the oxide stripes. For the structures for which the diffraction peaks from the substrate and the film overlap, the x-ray standing wave technique was applied for precise measurements of the strain with a Δd/d resolution of better than 10 -4 . (rapid communication)

An Experimental and Theoretical Investigation of Electrostatically Coupled Cantilever Microbeams

KAUST Repository

Ilyas, Saad; Chappanda, Karumbaiah N.; Hafiz, Md Abdullah Al; Ramini, Abdallah; Younis, Mohammad I.

2016-01-01

We present an experimental and theoretical investigation of the static and dynamic behavior of electrostatically coupled laterally actuated silicon microbeams. The coupled beam resonators are composed of two almost identical flexible cantilever

President Toomas Hendrik Ilves Will Speak At Columbia University

Index Scriptorium Estoniae

2010-01-01

President Toomas Hendrik Ilves esineb 22. septembril 2010 Columbia Ülikoolis kõnega ""Vana ja uus" Euroopa pärast Lissaboni lepingu jõustumist". Töövisiit Ameerika Ühendriikidesse 20.-27.09.2010

Monte Carlo dose calculation of microbeam in a lung phantom

International Nuclear Information System (INIS)

Company, F.Z.; Mino, C.; Mino, F.

1998-01-01

Full text: Recent advances in synchrotron generated X-ray beams with high fluence rate permit investigation of the application of an array of closely spaced, parallel or converging microplanar beams in radiotherapy. The proposed techniques takes advantage of the hypothesised repair mechanism of capillary cells between alternate microbeam zones, which regenerates the lethally irradiated endothelial cells. The lateral and depth doses of 100 keV microplanar beams are investigated for different beam dimensions and spacings in a tissue, lung and tissue/lung/tissue phantom. The EGS4 Monte Carlo code is used to calculate dose profiles at different depth and bundles of beams (up to 20x20cm square cross section). The maximum dose on the beam axis (peak) and the minimum interbeam dose (valley) are compared at different depths, bundles, heights, widths and beam spacings. Relatively high peak to valley ratios are observed in the lung region, suggesting an ideal environment for microbeam radiotherapy. For a single field, the ratio at the tissue/lung interface will set the maximum dose to the target volume. However, in clinical application, several fields would be involved allowing much greater doses to be applied for the elimination of cancer cells. We conclude therefore that multifield microbeam therapy has the potential to achieve useful therapeutic ratios for the treatment of lung cancer

Memory and survival after microbeam radiation therapy

International Nuclear Information System (INIS)

Schueltke, Elisabeth; Juurlink, Bernhard H.J.; Ataelmannan, Khalid; Laissue, Jean; Blattmann, Hans; Braeuer-Krisch, Elke; Bravin, Alberto; Minczewska, Joanna; Crosbie, Jeffrey; Taherian, Hadi; Frangou, Evan; Wysokinsky, Tomasz; Chapman, L. Dean; Griebel, Robert; Fourney, Daryl

2008-01-01

Background: Disturbances of memory function are frequently observed in patients with malignant brain tumours and as adverse effects after radiotherapy to the brain. Experiments in small animal models of malignant brain tumour using synchrotron-based microbeam radiation therapy (MRT) have shown a promising prolongation of survival times. Materials and methods: Two animal models of malignant brain tumour were used to study survival and memory development after MRT. Thirteen days after implantation of tumour cells, animals were submitted to MRT either with or without adjuvant therapy (buthionine-SR-sulfoximine = BSO or glutamine). We used two orthogonal 1-cm wide arrays of 50 microplanar quasiparallel microbeams of 25 μm width and a center-to-center distance of about 200 μm, created by a multislit collimator, with a skin entrance dose of 350 Gy for each direction. Object recognition tests were performed at day 13 after tumour cell implantation and in monthly intervals up to 1 year after tumour cell implantation. Results: In both animal models, MRT with and without adjuvant therapy significantly increased survival times. BSO had detrimental effects on memory function early after therapy, while administration of glutamine resulted in improved memory

Online imaging of initial DNA damages at the PTB microbeam

International Nuclear Information System (INIS)

Giesen, U.; Langner, F.; Mielke, C.; Mosconi, M.; Dirks, W. G.

2011-01-01

In an inter-disciplinary collaboration of Physikalisch-Technische Bundesanstalt (PTB), German Collection of Microorganisms and Cell Cultures (DSMZ) and Heinrich-Heine Univ., live-cell imaging has been established at the charged-particle microbeam facility of PTB. Candidate genes participating in DNA strand-break repair pathways such as PARP-1, MRE11, MSH2, MDC1 and p53BP1 have been modified to generate fluorescent fusion proteins. Using multi-cistronic expression vectors, stable genomic integration was achieved in HT-1080 fibroblasts. The aim of this study is to characterise and use these highly reliable cell lines for studying initial steps of DNA damage responses and kinetics of repair after microbeam irradiation with high- and low-linear energy transfer (LET) particles in living cells at physiological conditions. (authors)

Synchrotron microbeam irradiation induces neutrophil infiltration, thrombocyte attachment and selective vascular damage in vivo

OpenAIRE

Br?nnimann, Daniel; Bouchet, Audrey; Schneider, Christoph; Potez, Marine; Serduc, Rapha?l; Br?uer-Krisch, Elke; Graber, Werner; von Gunten, Stephan; Laissue, Jean Albert; Djonov, Valentin

2016-01-01

International audience; Our goal was the visualizing the vascular damage and acute inflammatory response to micro-and minibeam irradiation in vivo. Microbeam (MRT) and minibeam radiation therapies (MBRT) are tumor treatment approaches of potential clinical relevance, both consisting of parallel X-ray beams and allowing the delivery of thousands of Grays within tumors. We compared the effects of microbeams (25– 100 μm wide) and minibeams (200–800 μm wide) on vasculature, inflammation and surro...

Nonlinear behavior of capacitive micro-beams based on strain gradient theory

International Nuclear Information System (INIS)

Fathalilou, Mohammad; Sadeghi, Morteza; Rezazadeh, Ghader

2014-01-01

This paper studies the size dependent behavior of materials in MEMS structures. This behavior becomes noticeable for a structure when the characteristic size such as thickness or diameter is close to its internal length-scale parameter and is insignificant for the high ratio of the characteristic size to the length-scale parameter, which is the case of the silicon base micro-beams. However, in some types of micro-beams like gold or nickel bases, the size dependent effect cannot be overlooked. In such cases, ignoring this behavior in modeling will lead to incorrect results. Some previous researchers have applied classic beam theory on their models and imposed a considerable hypothetical value of residual stress to match their theoretical results with the experimental ones. The equilibrium positions or fixed points of the gold and nickel micro-beams are obtained and shown that for a given DC voltage, there is a considerable difference between the obtained fixed points using classic beam theory, modified couple stress theory, and modified strain gradient theory. In addition, it is shown that the calculated static and dynamic pull-in voltages using higher order theories are much closer to the experimental results and are higher several times than those obtained by classic beam theory.

Heavy Ion Microbeam and Broadbeam Transients in SiGe HBTs

Science.gov (United States)

Pellish, Jonathan A.; Reed, Robert A.; McMorrow, Dale; Vizkelethy, Gyorgy; Dodd, Paul E.; Ferlet-Cavrois, Veronique; Baggio, Jacques; Paillet, Philippe; Duhamel, Olivier; Phillips, Stanley D.;

Influence of squeeze film damping on the higher-order modes of clamped–clamped microbeams

KAUST Repository

Alcheikh, Nouha

2016-05-06

This paper presents an experimental study and a finite-element analysis of the effect of squeeze film damping on the resonance frequency and quality factor of the higher-order flexure vibrations modes of clamped-clamped microbeams. Viscoelastic and silicon nitride microbeams are fabricated and are electrostatically actuated by various electrode configurations to trigger the first, second, and third modes. The damping characteristic and the resonance frequency of these modes are examined for a wide range of gas pressure and electrostatic voltage loads. The results of the silicon nitride beams and viscoelastic beams are compared. It is found that the intrinsic material loss is the major dissipation mechanism at low pressure for the viscoelastic microbeams, significantly limiting their quality factor. It is also found that while the silicon nitride beams show higher quality factors at the intrinsic and molecular regimes of pressure, due to their low intrinsic loss, their quality factors near atmospheric pressure are lower than those of the viscoelastic microbeams. Further, the higher-order modes of all the beams show much higher quality factors at atmospheric pressure compared to the first mode, which could be promising for operating such resonators in air. Experimental results and finite element model simulations show good agreement for resonance frequency and quality factor for the three studied modes. © 2016 IOP Publishing Ltd.

Diagnosis of spatial resolution for microbeam scanning PIXE using STIM method and CR-39 track detector in PASTA

International Nuclear Information System (INIS)

Hamano, T.; Imaseki, H.; Yukawa, M.; Ishikawa, T.; Iso, H.; Matsumoto, K.

2003-01-01

In PIXE analysis system and Tandem Accelerator facility (PASTA) of NIRS, we are using Scanning Transmission Ion Microscopy (STIM) method and solid track detector to diagnose the spatial resolution of scanning microbeam PIXE analysis system. These methods are widely used by many microbeam facilities. (author)

Operation manual of microbeam system in Takasaki for biological application (MiST-BA)

International Nuclear Information System (INIS)

Sakashita, Tetsuya; Yokota, Yuichiro; Wada, Seiichi; Funayama, Tomoo; Kobayashi, Yasuhiko

2004-03-01

Microbeam System is a powerful tool for micro-radiosurgery studies and direct investigation of cell-to-cell communications such as 'bystander effects'. Microbeam system in Takasaki for biological application (MiST-BA) has been developed for several years and applied to some cases. There were fate mapping of the cellular blastoderm stage egg of the silkworm and bystander effects such as inhibition of cell proliferation, induction of micronuclei, and so on. The aim of this report (operation manual) is to provide a simple and easy usage of MiST-BA for current and new users. MiST-BA consists of three parts; (1) Offline microscope control system for cell-finding. (2) Online microscope control system for cell-targeting and irradiating, and (3) Beam shutter control system for cell irradiation with a precise number of heavy ions. The report presents the outline of MiST-BA, the operation protocol of each part, examples of a microbeam irradiation experiment using CHO-K1 cells, silkworm eggs, and Tobacco protoplast cells, and Trouble shooting. (author)

Neurocognitive sparing of desktop microbeam irradiation.

Science.gov (United States)

Bazyar, Soha; Inscoe, Christina R; Benefield, Thad; Zhang, Lei; Lu, Jianping; Zhou, Otto; Lee, Yueh Z

2017-08-11

Normal tissue toxicity is the dose-limiting side effect of radiotherapy. Spatial fractionation irradiation techniques, like microbeam radiotherapy (MRT), have shown promising results in sparing the normal brain tissue. Most MRT studies have been conducted at synchrotron facilities. With the aim to make this promising treatment more available, we have built the first desktop image-guided MRT device based on carbon nanotube x-ray technology. In the current study, our purpose was to evaluate the effects of MRT on the rodent normal brain tissue using our device and compare it with the effect of the integrated equivalent homogenous dose. Twenty-four, 8-week-old male C57BL/6 J mice were randomly assigned to three groups: MRT, broad-beam (BB) and sham. The hippocampal region was irradiated with two parallel microbeams in the MRT group (beam width = 300 μm, center-to-center = 900 μm, 160 kVp). The BB group received the equivalent integral dose in the same area of their brain. Rotarod, marble burying and open-field activity tests were done pre- and every month post-irradiation up until 8 months to evaluate the cognitive changes and potential irradiation side effects on normal brain tissue. The open-field activity test was substituted by Barnes maze test at 8th month. A multilevel model, random coefficients approach was used to evaluate the longitudinal and temporal differences among treatment groups. We found significant differences between BB group as compared to the microbeam-treated and sham mice in the number of buried marble and duration of the locomotion around the open-field arena than shams. Barnes maze revealed that BB mice had a lower capacity for spatial learning than MRT and shams. Mice in the BB group tend to gain weight at the slower pace than shams. No meaningful differences were found between MRT and sham up until 8-month follow-up using our measurements. Applying MRT with our newly developed prototype compact CNT-based image-guided MRT system

Development of the Jyvaeskylae microbeam facility

Energy Technology Data Exchange (ETDEWEB)

Norarat, Rattanaporn, E-mail: rattanaporn.norarat@phys.jyu.fi [Department of Physics, University of Jyvaeskylae, P.O. Box 35 (YFL), FIN-40014 Jyvaeskylae (Finland); Sajavaara, Timo; Laitinen, Mikko; Heikkinen, Pauli; Ranttila, Kimmo; Ylikorkala, Kari; Haenninen, Vaeinoe; Rossi, Mikko; Jones, Pete [Department of Physics, University of Jyvaeskylae, P.O. Box 35 (YFL), FIN-40014 Jyvaeskylae (Finland); Marjomaeki, Varpu; Gilbert, Leona [Department of Environmental and Biological Sciences, University of Jyvaeskylae, P.O. Box 35 (YFL), FIN-40014 Jyvaeskylae (Finland); Whitlow, Harry J. [Department of Physics, University of Jyvaeskylae, P.O. Box 35 (YFL), FIN-40014 Jyvaeskylae (Finland)

2012-02-01

Research highlights: Black-Right-Pointing-Pointer A MeV ion microbeam for biomedical materials research is being developed. Black-Right-Pointing-Pointer High accuracy scanning using electrostatic post-focus deflection. Black-Right-Pointing-Pointer Imaging and direct lithographic image writing using time-stamping methods. Black-Right-Pointing-Pointer New scanning modes and fluorescence detectors permit low ion-fluence cell imaging. Black-Right-Pointing-Pointer Thermal compensated beam-line support design for high positional accuracy. - Abstract: A new microbeam facility is being constructed at the 1.7 MV Pelletron Accelerator in Jyvaeskylae. The facility is designed for easy upgrading and incorporates a number of innovative features. Initially, it is based on a Heidelberg doublet with a design capability of a 3 Multiplication-Sign 5 {mu}m beamspot at PIXE intensities and later upgraded to nanobeam performance. A thermal-expansion compensated rigid frame mounted on a mechanically isolated floor section is used to support the ion optical components. A compact-post focusing electrostatic deflector is used for high linearity beam scanning. This together with a novel time-stamped data collection (TDC) allows dynamic effects in IBIC, fluorescence bleaching to be studied as well as facilitating multi-resolution image support for low-fluence imaging of cells. The target chamber is fitted with a novel low-cost large working distance optical microscope, extremely compact large solid angle photon detectors as well as conventional secondary electron, PIXE and Scanning Transmission Ion Microscopy (STIM) detectors.

Piezoelectric transduction of flexural modes in pre-stressed microbeam resonators

NARCIS (Netherlands)

Torri, G.B.; Janssen, N.M.A.; Zeng, Z.; Rottenberg, X.; Karabacak, D.M.; Vandecasteele, M.; Hoof, C.V.; Puers, R.; Tilmans, H.A.C.

2014-01-01

This paper reports on the optimization of the design of piezoelectric transducer elements integrated on doubly-clamped microbeam resonators utilized as (bio)chemical sensors. We report and emphasize the often forgotten influence of membrane stresses on defining the dimensions and optimal position of

Weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology

Science.gov (United States)

Laissue, Jean A.; Blattmann, Hans; Di Michiel, Marco; Slatkin, Daniel N.; Lyubimova, Nadia; Guzman, Raphael; Zimmermann, Werner; Birrer, Stephan; Bley, Tim; Kircher, Patrick; Stettler, Regina; Fatzer, Rosmarie; Jaggy, Andre; Smilowitz, Henry; Brauer, Elke; Bravin, Alberto; Le Duc, Geraldine; Nemoz, Christian; Renier, Michel; Thomlinson, William C.; Stepanek, Jiri; Wagner, Hans-Peter

2001-12-01

The cerebellum of the weanling piglet (Yorkshire) was used as a surrogate for the radiosensitive human infant cerebellum in a Swiss-led program of experimental microbeam radiation therapy (MRT) at the ESRF. Five weanlings in a 47 day old litter of seven, and eight weanlings in a 40 day old litter of eleven were irradiated in November, 1999 and June, 2000, respectively. A 1.5 cm-wide x 1.5 xm-high array of equally space approximately equals 20-30 micrometers wide, upright microbeams spaced at 210 micrometers intervals was propagated horizontally, left to right, through the cerebella of the prone, anesthetized piglets. Skin-entrance intra-microbeam peak adsorbed doses were uniform, either 150, 300, 425, or 600 gray (Gy). Peak and inter-microbeam (valley) absorbed doses in the cerebellum were computed with the PSI version of the Monte Carlo code GEANT and benchmarked using Gafchromic and radiochromic film microdosimetry. For approximately equals 66 weeks [first litter; until euthanasia], or approximately equals 57 weeks [second litter; until July 30, 2001] after irradiation, the littermates were developmentally, behaviorally, neurologically and radiologically normal as observed and tested by experienced farmers and veterinary scientists unaware of which piglets were irradiated or sham-irradiated. Morever, MRT implemented at the ESRF with a similar array of microbeams and a uniform skin-entrance peak dose of 625 Gy, followed by immunoprophylaxis, was shown to be palliative or curative in young adult rats bearing intracerebral gliosarcomas. These observations give further credence to MRT's potential as an adjunct therapy for brain tumors in infancy, when seamless therapeutic irradiation of the brain is hazardous.

Development of a Charged Particle Microbeam for Single-Particle Subcellular Irradiations at the MIT Laboratory for Accelerator Beam Application

International Nuclear Information System (INIS)

Yanch, Jacquelyn C.

2004-01-01

The development of a charged particle microbeam for single particle, subcellular irradiations at the Massachusetts Institute of Technology Laboratory for Accelerator Beam Applications (MIT LABA) was initiated under this NEER aeard. The Microbeam apparatus makes use of a pre-existing electrostatic accelerator with a horizontal beam tube

A new paradigm in radioadaptive response developing from microbeam research

International Nuclear Information System (INIS)

Matsumoto, Hideki; Tomita, Masanori; Otsuka, Kensuke; Hatashita, Masanori

2009-01-01

A classic paradigm in radiation biology asserts that all radiation effects on cells, tissues and organisms are due to the direct action of radiation on living tissue. Using this model, possible risks from exposure to low dose ionizing radiation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to higher doses of radiation, using a linear non-threshold model (LNT model). However, the validity of using this dose-response model is controversial because evidence accumulated over the past decade has indicated that living organisms, including humans, respond differently to low dose/low dose-rate radiation than they do to high dose/high dose-rate radiation. These important responses to low dose/low dose-rate radiation are the radiation-induced adaptive response, the bystander response, low-dose hypersensitivity, and genomic instability. The mechanisms underlying these responses often involve bio-chemical and molecular signals generated in response to targeted and non-targeted events. In order to define and understand the bystander response to provide a basis for the understanding of non-targeted events and to elucidate the mechanisms involved, recent sophisticated research has been conducted with X-ray microbeams and charged heavy particle microbeams, and these studies have produced many new observations. Based on these observations, associations have been suggested to exist between the radio-adaptive and bystander responses. The present review focuses on these two phenomena, and summarizes observations supporting their existence, and discusses the linkage between them in light of recent results obtained from experiments utilizing microbeams. (author)

Social sustainability of alternate transportation modes at the University of British Columbia

Energy Technology Data Exchange (ETDEWEB)

Cato, N. [British Columbia Univ., Vancouver, BC (Canada). TREK Program

2006-08-03

As a result of the University of British Columbia's U-Pass program, more than $3 million per month has been saved in transportation cost savings for the university and its students. In addition, greenhouse gas (GHG) emissions have been reduced by 16,000 tonnes per year. This research study examined the social implications of the U-Pass program and examined the social sustainability of alternate transportation modes, including cycling, walking, carpooling, and telecommuting. The report was intended as a preliminary investigation, and provided recommendations for future quantitative research. The study identified the social factors that caused student to resist using alternative transportation modes. Social factors were then evaluated in order to determine changes that could be made to encourage sustainable transportation choices. Results of the study suggested that the lack of availability and frequency of public transit buses was a significant barrier for students. More frequent service in the evenings and on weekends was recommended. The expansion of all-door boarding was recommended to reduce travel times. Other recommendations included investigating the feasibility of dedicated bus lanes; improving comfort and increasing travel speed; and introducing more effective ways of communicating route and schedule information, including the development of software programs for electronic devices. 12 refs., 4 tabs., 1 fig.

Size-dependent dynamic stability analysis of microbeams actuated by piezoelectric voltage based on strain gradient elasticity theory

Energy Technology Data Exchange (ETDEWEB)

Sahmani, Saeid; Bahrami, Mohsen [Amirkabir University of Technology, Tehran (Iran, Islamic Republic of)

2015-01-15

In the current paper, dynamic stability analysis of microbeams subjected to piezoelectric voltage is presented in which the microbeam is integrated with piezoelectric layers on the lower and upper surfaces. Both of the flutter and divergence instabilities of microbeams with clamped-clamped and clamped-free boundary conditions are predicted corresponding to various values of applied voltage. To take size effect into account, the classical Timoshenko beam theory in conjunction with strain gradient elasticity theory is utilized to develop nonclassical beam model containing three additional internal length scale parameters. By using Hamilton's principle, the higher-order governing differential equations and associated boundary conditions are derived. Afterward, generalized differential quadrature method is employed to discretize the size-dependent governing differential equations along with clamped-clamped and clamped-free end supports. The critical piezoelectric voltages corresponding to various values dimensionless length scale parameter are evaluated and compared with those predicted by the classical beam theory. It is revealed that in the case of clamped-free boundary conditions, the both of flutter and divergence instabilities occur. However, for the clamped-clamped microbeams, only divergence instability takes place.

Effects of geometric nonlinearity in an adhered microbeam for measuring the work of adhesion

Science.gov (United States)

Fang, Wenqiang; Mok, Joyce; Kesari, Haneesh

2018-03-01

Design against adhesion in microelectromechanical devices is predicated on the ability to quantify this phenomenon in microsystems. Previous research related the work of adhesion for an adhered microbeam to the beam's unadhered length, and as such, interferometric techniques were developed to measure that length. We propose a new vibration-based technique that can be easily implemented with existing atomic force microscopy tools or similar metrology systems. To make such a technique feasible, we analysed a model of the adhered microbeam using the nonlinear beam theory put forth by Woinowsky-Krieger. We found a new relation between the work of adhesion and the unadhered length; this relation is more accurate than the one by Mastrangelo & Hsu (Mastrangelo & Hsu 1993 J. Microelectromech. S., 2, 44-55. (doi:10.1109/84.232594)) which is commonly used. Then, we derived a closed-form approximate relationship between the microbeam's natural frequency and its unadhered length. Results obtained from this analytical formulation are in good agreement with numerical results from three-dimensional nonlinear finite-element analysis.

Development of micro-optics for high-resolution IL spectroscopy with a proton microbeam probe

International Nuclear Information System (INIS)

Kada, Wataru; Satoh, Takahiro; Yokoyama, Akihito; Koka, Masashi; Kamiya, Tomihiro

2014-01-01

Confocal optics for ion luminescence (IL) was developed for the precise analysis of the chemical composition of microscopic targets with an external proton microbeam probe. Anti-reflection-coated confocal micro-lens optics with an effective focus area of approximately 800 × 800 μm was installed on the microbeam line of a single-ended accelerator. Chromatic aberrations of the confocal optics were examined at wavelengths of 300–900 nm. An electrically-cooled back-thinned charge coupled device spectrometer with a wavelength resolution of 0.5 nm was used for the microscopic spectroscopy and IL imaging of microscopic mineral targets. Simultaneous microscopic IL and micro-PIXE analysis were performed using an external 3 MeV H + microbeam with a current of less than 100 pA. A spectral resolution of 3 nm was achieved for a single IL peak which corresponded to Cr 3+ impurities in a single-crystal of aluminum oxide. The use of IL spectroscopy and imaging for aerosol targets revealed microscopic distributions of the chemical and elemental composition in the atmosphere

AstroCom NYC: A Partnership Between Astronomers at CUNY, AMNH, and Columbia University

Science.gov (United States)

Paglione, Timothy; Ford, K. S.; Robbins, D.; Mac Low, M.; Agueros, M. A.

2014-01-01

AstroCom NYC is a new program designed to improve urban minority student access to opportunities in astrophysical research by greatly enhancing partnerships between research astronomers in New York City. The partners are minority serving institutions of the City University of New York, and the astrophysics research departments of the American Museum of Natural History and Columbia. AstroCom NYC provides centralized, personalized mentoring as well as financial and academic support, to CUNY undergraduates throughout their studies, plus the resources and opportunities to further CUNY faculty research with students. The goal is that students’ residency at AMNH helps them build a sense of belonging in the field, and inspires and prepares them for graduate study. AstroCom NYC prepares students for research with a rigorous Methods of Scientific Research course developed specifically to this purpose, a laptop, a research mentor, career mentor, involvement in Columbia outreach activities, scholarships and stipends, Metrocards, and regular assessment for maximum effectiveness. Stipends in part alleviate the burdens at home typical for CUNY students so they may concentrate on their academic success. AMNH serves as the central hub for our faculty and students, who are otherwise dispersed among all five boroughs of the City. With our first cohort we experienced the expected challenges from their diverse preparedness, but also far greater than anticipated challenges in scheduling, academic advisement, and molding their expectations. We review Year 1 operations and outcomes, as well as plans for Year 2, when our current students progress to be peer mentors.

1993-1994 Final technical report for establishing the SECME Model in the District of Columbia

Energy Technology Data Exchange (ETDEWEB)

Vickers, R.G.

1995-12-31

This is the final report for a program to establish the SECME Model in the District of Columbia. This program has seen the development of a partnership between the District of Columbia Public Schools, the University of the District of Columbia, the Department of Energy, and SECME. This partnership has demonstrated positive achievement in mathematics and science education and learning in students within the District of Columbia.

1993-1994 Final technical report for establishing the SECME Model in the District of Columbia

International Nuclear Information System (INIS)

Vickers, R.G.

1995-01-01

This is the final report for a program to establish the SECME Model in the District of Columbia. This program has seen the development of a partnership between the District of Columbia Public Schools, the University of the District of Columbia, the Department of Energy, and SECME. This partnership has demonstrated positive achievement in mathematics and science education and learning in students within the District of Columbia

First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy

International Nuclear Information System (INIS)

Serduc, Raphael; Braeuer-Krisch, Elke; Bouchet, Audrey; Brochard, Thierry; Bravin, Alberto; Le Duc, Geraldine; Renaud, Luc; Laissue, Jean Albert

2009-01-01

The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p<0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated. (orig.)

First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy

Energy Technology Data Exchange (ETDEWEB)

Serduc, Raphael [Toulouse Univ. (France). UPS Centre de Recherche Cerveau et Cognition; CNRS, CerCo, Toulouse (France); European Synchrotron Radiation Facility, 38 - Grenoble (France); Braeuer-Krisch, Elke; Bouchet, Audrey; Brochard, Thierry; Bravin, Alberto; Le Duc, Geraldine [European Synchrotron Radiation Facility, 38 - Grenoble (France); Renaud, Luc [Toulouse Univ. (France). UPS Centre de Recherche Cerveau et Cognition; CNRS, CerCo, Toulouse (France); Laissue, Jean Albert [Bern Univ. (Switzerland). Inst. of Pathology

2009-07-15

The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p<0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated. (orig.)

Computational modelling of the cerebral cortical microvasculature: effect of x-ray microbeams versus broad beam irradiation

Science.gov (United States)

Merrem, A.; Bartzsch, S.; Laissue, J.; Oelfke, U.

2017-05-01

Microbeam Radiation Therapy is an innovative pre-clinical strategy which uses arrays of parallel, tens of micrometres wide kilo-voltage photon beams to treat tumours. These x-ray beams are typically generated on a synchrotron source. It was shown that these beam geometries allow exceptional normal tissue sparing from radiation damage while still being effective in tumour ablation. A final biological explanation for this enhanced therapeutic ratio has still not been found, some experimental data support an important role of the vasculature. In this work, the effect of microbeams on a normal microvascular network of the cerebral cortex was assessed in computer simulations and compared to the effect of homogeneous, seamless exposures at equal energy absorption. The anatomy of a cerebral microvascular network and the inflicted radiation damage were simulated to closely mimic experimental data using a novel probabilistic model of radiation damage to blood vessels. It was found that the spatial dose fractionation by microbeam arrays significantly decreased the vascular damage. The higher the peak-to-valley dose ratio, the more pronounced the sparing effect. Simulations of the radiation damage as a function of morphological parameters of the vascular network demonstrated that the distribution of blood vessel radii is a key parameter determining both the overall radiation damage of the vasculature and the dose-dependent differential effect of microbeam irradiation.

Vibration analysis of a rotating functionally graded tapered microbeam based on the modified couple stress theory by DQEM

Science.gov (United States)

Ghadiri, Majid; Shafiei, Navvab; Alireza Mousavi, S.

2016-09-01

Due to having difficulty in solving governing nonlinear differential equations of a non-uniform microbeam, a few numbers of authors have studied such fields. In the present study, for the first time, the size-dependent vibration behavior of a rotating functionally graded (FG) tapered microbeam based on the modified couple stress theory is investigated using differential quadrature element method (DQEM). It is assumed that physical and mechanical properties of the FG microbeam are varying along the thickness that will be defined as a power law equation. The governing equations are determined using Hamilton's principle, and DQEM is presented to obtain the results for cantilever and propped cantilever boundary conditions. The accuracy and validity of the results are shown in several numerical examples. In order to display the influence of size on the first two natural frequencies and consequently changing of some important microbeam parameters such as material length scale, rate of cross section, angular velocity and gradient index of the FG material, several diagrams and tables are represented. The results of this article can be used in designing and optimizing elastic and rotary-type micro-electro-mechanical systems like micro-motors and micro-robots including rotating parts.

Measurement of minute local strain in semiconductor materials and electronic devices by using a highly parallel X-ray microbeam

International Nuclear Information System (INIS)

Matsui, J.; Tsusaka, Y.; Yokoyama, K.; Takeda, S.; Katou, M.; Kurihara, H.; Watanabe, K.; Kagoshima, Y.; Kimura, S.

2003-01-01

We have developed an X-ray microbeam with a small angular divergence by adopting X-ray optics with successive use of asymmetric Bragg reflection from silicon crystals for the both polarizations of the synchrotron X-rays. The microbeam actually obtained is several microns in size and possesses an angular divergence of less than 2 arcsec which enables us to measure the strain of 10 -5 -10 -6 . By scanning the sample against the microbeam, distribution of the minute local strain in various regions of semiconductor crystals for electronic devices, e.g., the strain around the SiO 2 /Si film edge in silicon devices, the strain in an InGaAsP/InP stripe laser were measured

Laser-induced radiation microbeam technology and simultaneous real-time fluorescence imaging in live cells.

Science.gov (United States)

Botchway, Stanley W; Reynolds, Pamela; Parker, Anthony W; O'Neill, Peter

2012-01-01

The use of nano- and microbeam techniques to induce and identify subcellular localized energy deposition within a region of a living cell provides a means to investigate the effects of low radiation doses. Particularly within the nucleus where the propagation and processing of deoxyribonucleic acid (DNA) damage (and repair) in both targeted and nontargeted cells, the latter being able to study cell-cell (bystander) effects. We have pioneered a near infrared (NIR) femtosecond laser microbeam to mimic ionizing radiation through multiphoton absorption within a 3D femtoliter volume of a highly focused Gaussian laser beam. The novel optical microbeam mimics both complex ionizing and UV-radiation-type cell damage including double strand breaks (DSBs). Using the microbeam technology, we have been able to investigate the formation of DNA DSB and subsequent recruitment of repair proteins to the submicrometer size site of damage introduced in viable cells. The use of a phosphorylated H2AX (γ-H2AX a marker for DSBs, visualized by immunofluorescent staining) and real-time imaging of fluorescently labeling proteins, the dynamics of recruitment of repair proteins in viable mammalian cells can be observed. Here we show the recruitment of ATM, p53 binding protein 1 (53BP1), and RAD51, an integral protein of the homologous recombination process in the DNA repair pathway and Ku-80-GFP involved in the nonhomologous end joining (NHEJ) pathway as exemplar repair process to show differences in the repair kinetics of DNA DSBs. The laser NIR multiphoton microbeam technology shows persistent DSBs at later times post laser irradiation which are indicative of DSBs arising at replication presumably from UV photoproducts or clustered damage containing single strand breaks (SSBs) that are also observed. Effects of the cell cycle may also be investigated in real time. Postirradiation and fixed cells studies show that in G1 cells a fraction of multiphoton laser-induced DSBs is persistent for >6h

A proton microbeam deflection system to scan target surfaces

International Nuclear Information System (INIS)

Heck, D.

1978-12-01

A system to deflect the proton beam within the Karlsruhe microbeam setup is described. The deflection is achieved whithin a transverse electrical field generated between parallel electrodes. Their tension is controlled by a pattern generator, thus enabling areal and line scans with a variable number of scan points at variable scan speed. The application is demonstrated at two different examples. (orig.) [de

PREFACE: EMAS 2013 Workshop: 13th European Workshop on Modern Developments and Applications in Microbeam Analysis

Science.gov (United States)

Llovet, Xavier, Dr; Matthews, Mr Michael B.; Brisset, François, Dr; Guimarães, Fernanda, Dr; Vieira, Professor Joaquim M., Dr

2014-03-01

This volume of the IOP Conference Series: Materials Science and Engineering contains papers from the 13th Workshop of the European Microbeam Analysis Society (EMAS) on Modern Developments and Applications in Microbeam Analysis which took place from the 12th to the 16th of May 2013 in the Centro de Congressos do Alfândega, Porto, Portugal. The primary aim of this series of workshops is to assess the state-of-the-art and reliability of microbeam analysis techniques. The workshops also provide a forum where students and young scientists starting out on a career in microbeam analysis can meet and discuss with the established experts. The workshops have a very specific format comprising invited plenary lectures by internationally recognized experts, poster presentations by the participants and round table discussions on the key topics led by specialists in the field. This workshop was organized in collaboration with LNEG - Laboratório Nacional de Energia e Geologia and SPMICROS - Sociedade Portuguesa de Microscopia. The technical programme included the following topics: electron probe microanalysis, future technologies, electron backscatter diffraction (EBSD), particle analysis, and applications. As at previous workshops there was also a special oral session for young scientists. The best presentation by a young scientist was awarded with an invitation to attend the 2014 Microscopy and Microanalysis meeting at Hartford, Connecticut. The prize went to Shirin Kaboli, of the Department of Metals and Materials Engineering of McGill University (Montréal, Canada), for her talk entitled ''Plastic deformation studies with electron channelling contrast imaging and electron backscattered diffraction''. The continuing relevance of the EMAS workshops and the high regard in which they are held internationally can be seen from the fact that 74 posters from 21 countries were on display at the meeting and that the participants came from as far away as Japan, Canada and the USA. A

A Galerkin-Parameterization Method for the Optimal Control of Smart Microbeams

Directory of Open Access Journals (Sweden)

Marwan Abukhaled

2009-01-01

Full Text Available A proposed computational method is applied to damp out the excess vibrations in smart microbeams, where the control action is implemented using piezoceramic actuators. From a mathematical point of view, we wish to determine the optimal boundary actuators that minimize a given energy-based performance measure. The minimization of the performance measure over the actuators is subjected to the full motion of the structural vibrations of the micro-beams. A direct state-control parametrization approach is proposed where the shifted Legendre polynomials are employed to solve the optimization problem. Legendre operational matrix and the properties of Kronecker product are utilized to find the approximated optimal trajectory and optimal control law of the lumped parameter systems with respect to the quadratic cost function by solving linear algebraic equations. Numerical examples are provided to demonstrate the applicability and efficiency of the proposed approach.

Measurement of minute local strain in semiconductor materials and electronic devices by using a highly parallel X-ray microbeam

CERN Document Server

Matsui, J; Yokoyama, K; Takeda, S; Katou, M; Kurihara, H; Watanabe, K; Kagoshima, Y; Kimura, S

2003-01-01

We have developed an X-ray microbeam with a small angular divergence by adopting X-ray optics with successive use of asymmetric Bragg reflection from silicon crystals for the both polarizations of the synchrotron X-rays. The microbeam actually obtained is several microns in size and possesses an angular divergence of less than 2 arcsec which enables us to measure the strain of 10 sup - sup 5 -10 sup - sup 6. By scanning the sample against the microbeam, distribution of the minute local strain in various regions of semiconductor crystals for electronic devices, e.g., the strain around the SiO sub 2 /Si film edge in silicon devices, the strain in an InGaAsP/InP stripe laser were measured.

Measurement of minute local strain in semiconductor materials and electronic devices by using a highly parallel X-ray microbeam

Energy Technology Data Exchange (ETDEWEB)

Matsui, J. E-mail: matsui@sci.himeji-tech.ac.jp; Tsusaka, Y.; Yokoyama, K.; Takeda, S.; Katou, M.; Kurihara, H.; Watanabe, K.; Kagoshima, Y.; Kimura, S

2003-01-01

We have developed an X-ray microbeam with a small angular divergence by adopting X-ray optics with successive use of asymmetric Bragg reflection from silicon crystals for the both polarizations of the synchrotron X-rays. The microbeam actually obtained is several microns in size and possesses an angular divergence of less than 2 arcsec which enables us to measure the strain of 10{sup -5}-10{sup -6}. By scanning the sample against the microbeam, distribution of the minute local strain in various regions of semiconductor crystals for electronic devices, e.g., the strain around the SiO{sub 2}/Si film edge in silicon devices, the strain in an InGaAsP/InP stripe laser were measured.

Knowledge Is "a Form of Venture Capital" for a Top Columbia Administrator.

Science.gov (United States)

Blumenstyk, Goldie

2001-01-01

Explains how for Michael M. Crow, executive vice provost at Columbia University, knowledge is a form of venture capital. This means pushing Columbia beyond the usual role of creating knowledge and disseminating it in traditional manners, and instead taking the knowledge, incubating it, and projecting it using tools like the Internet. (SM)

The Fu Foundation School of Engineering & Applied Science - Columbia

Science.gov (United States)

Engineering Mechanics Computer Science Earth and Environmental Engineering Electrical Engineering Industrial Engineering & Applied Science - Columbia University Admissions Undergraduates Graduates Distance Learning Physics and Applied Mathematics Biomedical Engineering Chemical Engineering Civil Engineering and

New capabilities of the Zagreb ion microbeam system

International Nuclear Information System (INIS)

Jaksic, M.; Bogdanovic Radovic, I.; Bogovac, M.; Desnica, V.; Fazinic, S.; Karlusic, M.; Medunic, Z.; Muto, H.; Pastuovic, Z.; Siketic, Z.; Skukan, N.; Tadic, T.

2007-01-01

The installation of a new 1.0 MV Tandetron accelerator and a recent upgrade of the 6.0 MV Tandem Van de Graaff accelerator increased the application possibilities of the Zagreb ion microbeam system. Several ion sources enable now the selection of a wide variety of ions. Most of them can be focused by the existing microprobe system. Sample positioning tools and new scanner control options are implemented in the new generation of SPECTOR data acquisition system. Details of the upgrades are presented

Continuation of mitosis after selective laser microbeam destruction of the centriolar region

Energy Technology Data Exchange (ETDEWEB)

Berns, N.W.; Richardson, S.M.

1977-12-01

The centriole regions of prophase PTK2 cells were irradiated with a laser microbeam. Cells continued through mitosis normally. Ultrastructural analysis revealed either an absence of centrioles or severely damaged centrioles at the irradiated poles. Microtubules appeared to focus into pericentriolar cloud material.

Continuation of mitosis after selective laser microbeam destruction of the centriolar region

International Nuclear Information System (INIS)

Berns, N.W.; Richardson, S.M.

1977-01-01

The centriole regions of prophase PTK2 cells were irradiated with a laser microbeam. Cells continued through mitosis normally. Ultrastructural analysis revealed either an absence of centrioles or severely damaged centrioles at the irradiated poles. Microtubules appeared to focus into pericentriolar cloud material

An Experimental and Theoretical Investigation of Electrostatically Coupled Cantilever Microbeams

KAUST Repository

Ilyas, Saad

2016-06-16

We present an experimental and theoretical investigation of the static and dynamic behavior of electrostatically coupled laterally actuated silicon microbeams. The coupled beam resonators are composed of two almost identical flexible cantilever beams forming the two sides of a capacitor. The experimental and theoretical analysis of the coupled system is carried out and compared against the results of beams actuated with fixed electrodes individually. The pull-in characteristics of the electrostatically coupled beams are studied, including the pull-in time. The dynamics of the coupled dual beams are explored via frequency sweeps around the neighborhood of the natural frequencies of the system for different input voltages. Good agreement is reported among the simulation results and the experimental data. The results show considerable drop in the pull-in values as compared to single microbeam resonators. The dynamics of the coupled beam resonators are demonstrated as a way to increase the bandwidth of the resonator near primary resonance as well as a way to introduce increased frequency shift, which can be promising for resonant sensing applications. Moreover the dynamic pull-in characteristics are also studied and proposed as a way to sense the shift in resonance frequency.

Optical Fiber-Tip Sensors Based on In-Situ µ-Printed Polymer Suspended-Microbeams.

Science.gov (United States)

Yao, Mian; Ouyang, Xia; Wu, Jushuai; Zhang, A Ping; Tam, Hwa-Yaw; Wai, P K A

2018-06-05

Miniature optical fiber-tip sensors based on directly µ-printed polymer suspended-microbeams are presented. With an in-house optical 3D μ-printing technology, SU-8 suspended-microbeams are fabricated in situ to form Fabry⁻Pérot (FP) micro-interferometers on the end face of standard single-mode optical fiber. Optical reflection spectra of the fabricated FP micro-interferometers are measured and fast Fourier transform is applied to analyze the cavity of micro-interferometers. The applications of the optical fiber-tip sensors for refractive index (RI) sensing and pressure sensing, which showed 917.3 nm/RIU to RI change and 4.29 nm/MPa to pressure change, respectively, are demonstrated in the experiments. The sensors and their optical µ-printing method unveil a new strategy to integrate complicated microcomponents on optical fibers toward 'lab-on-fiber' devices and applications.

A study of x-ray microbeam stress measurement for local area

International Nuclear Information System (INIS)

Natsume, Yoshitaka; Miyakawa, Susumu

1987-01-01

A new type X-ray microbeam equipment which is capable of three-dimensional oscillation at an X-ray radiation position was used to measure the residual stress of pure iron powder and bending plate specimens as well as that in the vicinity of fatigue crack tip of 1/2 CT specimen. The results obtained are summerized as follows. (1) Diffraction profiles of pure iron powder with diameter 0.02 ∼ 0.03 μm particle size obtained by the present microbeam technique in the beam area of 80 μm in diamether and measuring time more than 800 sec showed Kα 1 and Kα 2 peaks clearly, so that these profiles are good enough for stress measurement. (2) The measured stress of pure iron powder with diameter 10 ∼ 25 μm particle size in the beam area of 80 μm in diameter was not equal to 0 MPa. The measured stress varied greatly and was independent of measuring time. (3) The measured stress of pure iron powder with diameter 0.02 ∼ 0.03 μm particle size in the beam area of 80 μm in diameter was almost 1 MPa, which shows the good accuracy of this X-ray micro-beam equipment. (4) The relation between the X-ray measured stress and the mechanically applied stress showed good agreement. (5) The distribution of residual stress at the vicinity of fatigue crack tip showed that the residual stress at the fatigue crack tip was compression and the residual stress in front of crack tip was tension. This tensile residual stress in front of crack tip existed in the area from 0.02 mm to 2 mm. (6) The above results show that the present equipment is advantageous in the investigation of local stress, shortening the measuring time without sacrificing the accuracy. (author)

Parameter identification of an electrically actuated imperfect microbeam

KAUST Repository

Ruzziconi, Laura

2013-12-01

In this study we consider a microelectromechanical system (MEMS) and focus on extracting analytically the model parameters that describe its non-linear dynamic features accurately. The device consists of a clamped-clamped polysilicon microbeam electrostatically and electrodynamically actuated. The microbeam has imperfections in the geometry, which are related to the microfabrication process, resulting in many unknown and uncertain parameters of the device. The objective of the present paper is to introduce a simple but appropriate model which, despite the inevitable approximations, is able to describe and predict the most relevant aspects of the experimental response in a neighborhood of the first symmetric resonance. The modeling includes the main imperfections in the microstructure. The unknown parameters are settled via parametric identification. The approach is developed in the frequency domain and is based on matching both the frequency values and, remarkably, the frequency response curves, which are considered as the most salient features of the device response. Non-linearities and imperfections considerably complicate the identification process. Via the combined use of linear analysis and non-linear dynamic simulations, a single first symmetric mode reduced-order model is derived. Extensive numerical simulations are performed at increasing values of electrodynamic excitation. Comparison with experimental data shows a satisfactory concurrence of results not only at low electrodynamic voltage, but also at higher ones. This validates the proposed theoretical approach. We highlight its applicability, both in similar case-studies and, more in general, in systems. © 2013 Elsevier Ltd.

Columbia physics in the fifties: Untold tales

Directory of Open Access Journals (Sweden)

J. Sucher

2000-07-01

Full Text Available Eyvind Wichmann and I were both graduate students at Columbia University in the fifties, a decade of remarkable creativity by a star-studded physics faculty, which included some ten Nobel Laureates. I share some reminiscences about our time there and explain the role played in our relationship by an eightball.

Microbeam irradiation of the C. elegans nematode

International Nuclear Information System (INIS)

Bertucci, Antonella; Brenner, David J.; Pocock, Roger D.J.; Randers-Pehrson, Gerhard

2009-01-01

The understanding of complex radiation responses in biological systems, such as non-targeted effects as represented by the bystander response, can be enhanced by the use of genetically amenable model organisms. Almost all bystander studies to date have been carried out by using conventional single-cell in vitro systems, which are useful tools to characterize basic cellular and molecular responses. A few studies have been reported in monolayer explants and bystander responses have been also investigated in a three-dimensional normal human tissue system. However, despite the well-know usefulness of in vitro models, they cannot capture the complexity of radiation responses of living systems such as animal models. To carry out in vivo studies on the bystander effect we have developed a new technique to expose living organisms using proton microbeams. We report the use of a nematode C. elegans strain with a Green Fluorescent Protein (GFP) reporter for the hsp-4 heat-shock gene as an in vivo model for radiation studies. Exposing animals to heat and chemicals stressors leads to whole body increases in the hsp-4 protein reflected by enhanced fluorescence. We report here that γ-rays also can induce stress response in a dose dependent manner. However, whole body exposure to stress agents does not allow for evaluation of distance dependent response in non targeted tissues: the so-called bystander effect. We used the RARAF microbeam to site specifically deliver 3 MeV protons to a site in the tail of young worms. GFP expression was enhanced after 24 hours in a number dependent manner at distances > 100 μm from the site of irradiation. (author)

Higher order modes excitation of electrostatically actuated clamped–clamped microbeams: experimental and analytical investigation

KAUST Repository

Jaber, Nizar; Ramini, Abdallah; Carreno, Armando Arpys Arevalo; Younis, Mohammad I.

2016-01-01

© 2016 IOP Publishing Ltd. In this study, we demonstrate analytically and experimentally the excitations of the higher order modes of vibrations in electrostatically actuated clamped-clamped microbeam resonators. The concept is based on using

The mechanics of anaphase B in a basidiomycete as revealed by laser microbeam microsurgery

International Nuclear Information System (INIS)

Bayles, C.J.; Aist, J.R.; Berns, M.W.

1993-01-01

Bayles, C. J., Aist, J. R., and Berns, M. W. 1993. The mechanics of anaphase B in a basidiomycete as revealed by laser microbeam microsurgery. Experimental Mycology 17, 191-199. Cytoplasmic forces were found to be actively pulling on the spindle pole bodies during anaphase B in the dikaryotic, basidiomycete fungus, Helicobasidium mompa. When the spindle of one nucleus was severed with a laser microbeam at mid anaphase B, its two spindle pole bodies separated at a much faster rate than did those of the intact spindle in the other nucleus of the same cell. Since astral microtubule populations apparently reach their maximum during anaphase B in this fungus, we suggest that these microtubules may be involved in the cytoplasmic pulling forces. The spindle appears to act primarily as a governor, regulating the rate at which the spindle pole bodies are separated

Feasibility of employing thick microbeams from superficial and orthovoltage kVp x-ray tubes for radiotherapy of superficial cancers

Science.gov (United States)

Kamali-Zonouzi, P.; Shutt, A.; Nisbet, A.; Bradley, D. A.

2017-11-01

Preclinical investigations of thick microbeams show these to be feasible for use in radiotherapeutic dose delivery. To create the beams we access a radiotherapy x-ray tube that is familiarly used within a conventional clinical environment, coupling this with beam-defining grids. Beam characterisation, both single and in the form of arrays, has been by use of both MCNP simulation and direct Gafchromic EBT film dosimetry. As a first step in defining optimal exit-beam profiles over a range of beam energies, simulation has been made of the x-ray tube and numbers of beam-defining parallel geometry grids, the latter being made to vary in thickness, slit separation and material composition. For a grid positioned after the treatment applicator, and of similar design to those used in the first part of the study, MCNP simulation and Gafchromic EBT film were then applied in examining the resultant radiation profiles. MCNP simulations and direct dosimetry both show useful thick microbeams to be produced from the x-ray tube, with peak-to-valley dose ratios (PVDRs) in the approximate range 8.8-13.9. Although the potential to create thick microbeams using radiotherapy x-ray tubes and a grid has been demonstrated, Microbeam Radiation Therapy (MRT) would still need to be approved outside of the preclinical setting, a viable treatment technique of clinical interest needing to benefit for instance from substantially improved x-ray tube dose rates.

Photoacoustic microbeam-oscillator with tunable resonance direction and amplitude

Science.gov (United States)

Wu, Qingjun; Li, Fanghao; Wang, Bo; Yi, Futing; Jiang, J. Z.; Zhang, Dongxian

2018-01-01

We successfully design one photoacoustic microbeam-oscillator actuated by nanosecond laser, which exhibits tunable resonance direction and amplitude. The mechanism of laser induced oscillation is systematically analyzed. Both simulation and experimental results reveal that the laser induced acoustic wave propagates in a multi-reflected mode, resulting in resonance in the oscillator. This newly-fabricated micrometer-sized beam-oscillator has an excellent actuation function, i.e., by tuning the laser frequency, the direction and amplitude of actuation can be efficiently altered, which will have potential industrial applications.

How the Use of Remote Sensing is Transferred to Diverse User Communities Through Capacity Building at Columbia University

Science.gov (United States)

Ceccato, P.; Bell, M. A.; Mantilla, G.; Thomson, M. C.

2012-12-01

This presentation will provide an overview of capacity-building activities developed by the International Research Institute for Climate and Society to help diverse stakeholder communities use remote sensing to monitor climate and environmental factors that influence public health, natural disasters and food security. Teaching at a graduate level at Columbia University, at summer institutes and in counties, we developed training modules and case studies on how to combine remote sensing data to monitor precipitation, temperature, vegetation, and water bodies with climate information and field data (e.g. fires, infectious disease incidence, Desert Locusts) to 1) understand the relationship between climate, environmental factors and specific challenges to development and 2) provide methodologies and tools to forecast and better manage the problems. At Columbia University, we have developed a graduate course that provides the practical and theoretical foundations for the application of remote sensing techniques to the identification and monitoring of environmental change. We use the IRI Data Library, an online tool, to i) manage diverse data, ii) visualize data, iii) analyze remote sensing images and iii) combine data from different sources (e.g., fires, public health, natural disasters, agriculture). The IRI Data Library tool allows the users to analyze on-line climatic and environmental factors in relation to particular problems at various space and time scales. A Summer Institute on Climate Information for Public Health, first developed in 2008, has brought together experts from the public health and climate communities at the IRI to learn how to integrate climate and environmental factors with public health issues. In countries and regions, we also provide training for climate and public health working professionals in Madagascar, Ethiopia, Eritrea, Colombia and the Mercosur Region (including Uruguay, Paraguay, Brazil and Argentina).

Nonlinear dynamics of an electrically actuated imperfect microbeam resonator: Experimental investigation and reduced-order modeling

KAUST Repository

Ruzziconi, Laura; Bataineh, Ahmad M.; Younis, Mohammad I.; Cui, Weili; Lenci, Stefano

2013-01-01

We present a study of the dynamic behavior of a microelectromechanical systems (MEMS) device consisting of an imperfect clamped-clamped microbeam subjected to electrostatic and electrodynamic actuation. Our objective is to develop a theoretical

PIXE/PIGE characterisation of emeralds using an external micro-beam

International Nuclear Information System (INIS)

Calligaro, T.; Dran, J.-C.; Poirot, J.-P.; Querre, G.; Salomon, J.; Zwaan, J.C.

2000-01-01

A large collection of emeralds of various occurrences has been analysed by PIXE/PIGE in view to establish a compositional database. Major elements (Be, Si, Al) and trace elements (Li, F, Na, Mg, Ca, Rb, Cs and transition metals) are determined using an external 3 MeV proton micro-beam. Elemental micro-mapping permits to select the useful provenance tracers. This database was applied to infer the origin of several ancient emeralds set on historical jewels

Extended abstracts: Microbeam Probes of Cellular Radiation Response [final report

International Nuclear Information System (INIS)

Brenner, David J.

2000-01-01

In July 1999, we organized the 4th International Workshop: Microbeam Probes of Cellular Radiation Response, held in Killiney Bay, Dublin, Ireland, on July 17-18. Roughly 75 scientists (about equal numbers of physicists and biologists) attended the workshop, the fourth in a bi-annual series. Extended abstracts from the meeting were published in the Radiation Research journal, vol. 153, iss. 2, pp. 220-238 (February 2000)(attached). All the objectives in the proposal were met

Detection of minute strain in very local areas of materials by using an X-ray microbeam

CERN Document Server

Matsui, J; Tsusaka, Y; Kimura, S

2003-01-01

In order to analyze the local minute strain in semiconductor materials and devices, we have demonstrated formation of X-ray microbeams by using asymmetric Bragg reflections of the crystal and a zone plate or cylindrical mirror combined with synchrotron radiation. A series of X-ray rocking curves have been obtained by scanning the sample with using the X-ray microbeam. In addition, reciprocal space maps have also been obtained by inserting an analyzer crystal behind the sample. From these data, information on the strain distribution can be obtained for various samples, such as the strain near SiO sub 2 /Si film edges, that in silicon-on-insulator (SOI) crystals, and that in InGaAsP semiconductor laser stripes. (author)

High resolution X-ray fluorescence imaging for a microbeam radiation therapy treatment planning system

Science.gov (United States)

Chtcheprov, Pavel; Inscoe, Christina; Burk, Laurel; Ger, Rachel; Yuan, Hong; Lu, Jianping; Chang, Sha; Zhou, Otto

2014-03-01

Microbeam radiation therapy (MRT) uses an array of high-dose, narrow (~100 μm) beams separated by a fraction of a millimeter to treat various radio-resistant, deep-seated tumors. MRT has been shown to spare normal tissue up to 1000 Gy of entrance dose while still being highly tumoricidal. Current methods of tumor localization for our MRT treatments require MRI and X-ray imaging with subject motion and image registration that contribute to the measurement error. The purpose of this study is to develop a novel form of imaging to quickly and accurately assist in high resolution target positioning for MRT treatments using X-ray fluorescence (XRF). The key to this method is using the microbeam to both treat and image. High Z contrast media is injected into the phantom or blood pool of the subject prior to imaging. Using a collimated spectrum analyzer, the region of interest is scanned through the MRT beam and the fluorescence signal is recorded for each slice. The signal can be processed to show vascular differences in the tissue and isolate tumor regions. Using the radiation therapy source as the imaging source, repositioning and registration errors are eliminated. A phantom study showed that a spatial resolution of a fraction of microbeam width can be achieved by precision translation of the mouse stage. Preliminary results from an animal study showed accurate iodine profusion, confirmed by CT. The proposed image guidance method, using XRF to locate and ablate tumors, can be used as a fast and accurate MRT treatment planning system.

The ionoluminescence apparatus at the LABEC external microbeam facility

International Nuclear Information System (INIS)

Calusi, S.; Colombo, E.; Giuntini, L.; Giudice, A. Lo; Manfredotti, C.; Massi, M.; Pratesi, G.; Vittone, E.

2008-01-01

In this paper, we describe the main features of the ionoluminescence (IL) apparatus recently installed at the external scanning microbeam facility of the 3 MV Tandetron accelerator of the INFN LABEC Laboratory in Firenze. The peculiarity of this IL set-up resides in the fact that the light produced by the ion irradiation of the specimen is collected by a bifurcated optical fiber, so that photons are shunted both to a CCD spectrometer, working in the 200-900 nm wavelength range, and to a photomultiplier (PMT). The accurate focusing of the optical system allows high photon collection efficiency and this results in rapid acquisition of luminescence spectra with low ion currents on luminescent materials; simultaneously, luminescence maps with a spatial resolution of 10 μm can be acquired through the synchronization of PMT photon detection with the position of the scanning focused ion beam. An optical filter with a narrow passband facing the photomultiplier allows chromatic selectivity of the luminescence centres. The IL apparatus is synergistically integrated into the existing set-up for ion beam analyses (IBA). The upgraded system permits simultaneous IL and PIXE/PIGE/BS measurements. With our integrated system, we have been studying raw lapis lazuli samples of different known origins and precious lapis lazuli artworks of the Collezione Medicea of Museum of Natural History, University of Firenze, aiming at characterising their composition and provenance

The ionoluminescence apparatus at the LABEC external microbeam facility

Energy Technology Data Exchange (ETDEWEB)

Calusi, S.; Colombo, E. [INFN Sezione di Torino, Via P.Giuria 1, 10125 Torino (Italy); Dipartimento di Fisica Sperimentale and NIS Excellence Centre, Universita di Torino, Via P. Giuria 1, 10125 Torino (Italy); Giuntini, L. [Dipartimento di Fisica, Universita and INFN Sezione di Firenze, Via Sansone 1, 50019, Sesto Fiorentino, Firenze (Italy)], E-mail: giuntini@fi.infn.it; Giudice, A. Lo [Dipartimento di Fisica Sperimentale and NIS Excellence Centre, Universita di Torino, Via P. Giuria 1, 10125 Torino (Italy); Manfredotti, C. [INFN Sezione di Torino, Via P.Giuria 1, 10125 Torino (Italy); Dipartimento di Fisica Sperimentale and NIS Excellence Centre, Universita di Torino, Via P. Giuria 1, 10125 Torino (Italy); Massi, M. [Dipartimento di Fisica, Universita and INFN Sezione di Firenze, Via Sansone 1, 50019, Sesto Fiorentino, Firenze (Italy); Pratesi, G. [Dipartimento di Scienze della Terra and Museo di Storia Naturale, Universita di Firenze, Via G. La Pira 4, 50121 Firenze (Italy); Vittone, E. [INFN Sezione di Torino, Via P.Giuria 1, 10125 Torino (Italy); Dipartimento di Fisica Sperimentale and NIS Excellence Centre, Universita di Torino, Via P. Giuria 1, 10125 Torino (Italy)

2008-05-15

In this paper, we describe the main features of the ionoluminescence (IL) apparatus recently installed at the external scanning microbeam facility of the 3 MV Tandetron accelerator of the INFN LABEC Laboratory in Firenze. The peculiarity of this IL set-up resides in the fact that the light produced by the ion irradiation of the specimen is collected by a bifurcated optical fiber, so that photons are shunted both to a CCD spectrometer, working in the 200-900 nm wavelength range, and to a photomultiplier (PMT). The accurate focusing of the optical system allows high photon collection efficiency and this results in rapid acquisition of luminescence spectra with low ion currents on luminescent materials; simultaneously, luminescence maps with a spatial resolution of 10 {mu}m can be acquired through the synchronization of PMT photon detection with the position of the scanning focused ion beam. An optical filter with a narrow passband facing the photomultiplier allows chromatic selectivity of the luminescence centres. The IL apparatus is synergistically integrated into the existing set-up for ion beam analyses (IBA). The upgraded system permits simultaneous IL and PIXE/PIGE/BS measurements. With our integrated system, we have been studying raw lapis lazuli samples of different known origins and precious lapis lazuli artworks of the Collezione Medicea of Museum of Natural History, University of Firenze, aiming at characterising their composition and provenance.

Nitric oxide mediated bystander responses induced by microbeam targeted cells

International Nuclear Information System (INIS)

Shao, C.; Prise, K.M.; Folkard, M.; Michael, B.D.

2003-01-01

Considerable evidence has recently been accumulated in support of the existence of a 'bystander effect', which cells having received no irradiation show biological consequences from their vicinal irradiated cells. The application of microbeams is providing new insights into the radiation-induced bystander effect. The present study found that when a fraction of radioresistant human glioblastoma cells were individually targeted with a precise number of helium ions generated from the Gray Cancer Institute Charged Particle Microbeam, micronucleus (MN) induction significantly exceeded the expected value that was calculated from the number of MN observed when all of the cells were targeted assuming no bystander effect occurring. Even when only a single cell within a population was hit by one helium ion, the MN induction in the population could be increased by 16%. These results provide direct evidence of radiation-induced bystander effect. Moreover, MN was effectively induced in the unirradiated primary human fibroblasts and glioblastoma cells either co-cultured with irradiated cells or treated with the medium harvested from irradiated cells, indicating a signal molecule was produced from the irradiated cells. However, when c-PTIO, a nitric oxide (NO)-specific scavenger, was present in the medium during and after irradiation until MN analysis, the production of MN in all of the above cases was reduced to low levels. Consequently, NO plays an important role in the radiation-induced bystander effect

3 Columbia U. students win Goldwater Fellowship

CERN Multimedia

Zaragovia, V

2003-01-01

"Noah Burns, Kiril Datchev, and Lawrence David, are the University of Columbia's three recipients of the Barry M. Goldwater Scholarship. This is an award of $7,500 given annually to cover expenses such as tuition, fees, books and room and board, to about 300 individuals nationwide. The scholarship aims to encourage outstanding students to pursue careers in mathematics, the natural sciences or engineering" (1 page).

Analysis of the X-ray microbeam test result of the flash memories

International Nuclear Information System (INIS)

Yan Yihua; Ding Lili; Chen Wei; Guo Hongxia; Guo Xiaoqiang; Lin Dongsheng; Zhang Keying; Zhang Fengqi; Deng Yuliang; Fan Ruyu

2013-01-01

Background: The failure phenomenon is difficult to analyze for the flash memories when the whole chip is exposed to irradiation since both the memory array and the peripheral circuits might be degraded. Purpose: In order to detect the radiation susceptibility and corresponding phenomenon of the related circuits that included in the flash memories, the X-ray microbeam is used as the radiation source instead of 60 Co. Methods: The failure phenomenon is studied respectively when the memory array, decoder circuits, the charge pump circuits as well as the I/O circuits are exposed to radiation. The errors are mapped according to the logical address and the failure mechanism is analyzed based on the circuits. Results: Irradiated on the memory .array win lead to regularly distributed 0→1 bit flips, while only 1→0 are found when the row decoder is under exposure. Degradation of the charge pump circuits would lead to the erase/program functional failure. Conclusions: The results suggest that the X-ray microbeam radiation test is a good method for detecting the radiation susceptibility of the integrated circuits that contains lots of circuit modules. (authors)

Free vibration analysis of magneto-electro-elastic microbeams subjected to magneto-electric loads

Science.gov (United States)

Vaezi, Mohamad; Shirbani, Meisam Moory; Hajnayeb, Ali

2016-01-01

Different types of actuating and sensing mechanisms are used in new micro and nanoscale devices. Therefore, a new challenge is modeling electromechanical systems that use these mechanisms. In this paper, free vibration of a magnetoelectroelastic (MEE) microbeam is investigated in order to obtain its natural frequencies and buckling loads. The beam is simply supported at both ends. External electric and magnetic potentials are applied to the beam. By using the Hamilton's principle, the governing equations and boundary conditions are derived based on the Euler-Bernoulli beam theory. The equations are solved, analytically to obtain the natural frequencies of the MEE microbeam. Furthermore, the effects of external electric and magnetic potentials on the buckling of the beam are analyzed and the critical values of the potentials are obtained. Finally, a numerical study is conducted. It is found that the natural frequency can be tuned directly by changing the magnetic and electric potentials. Additionally, a closed form solution for the normalized natural frequency is derived, and buckling loads are calculated in a numerical example.

Marvels and Shadows: Science and Education at the University of Puerto Rico School of Tropical Medicine under the Auspices of Columbia University: An Introduction.

Science.gov (United States)

Mayo-Santana, Raúl; Rabionet, Silvia E; Peña-Carro, Lucy; Serrano, Adelfa E

2016-06-01

This essay introduces a series of five historical articles on the scientific and educational contributions of the University of Puerto Rico School of Tropical Medicine (STM), under the auspices of Columbia University (1926-1949), to the fields of tropical medicine and public health. The articles will appear in several consecutive issues, and will address various themes as follows: 1) historical antecedents of the STM, particularly institutional precedents; 2) the educational legacy of the STM; 3) a history of the STM scientific journal ("The Puerto Rico Journal of Public Health and Tropical Medicine"); 4) the scientific practices and representations that prevailed at the institution; and, 5) a brief sociocultural history of malaria in Puerto Rico, mainly from the perspective of the STM's scientific and public health activities. The authors have systematically and comprehensively studied a wide variety of documents from different sources based on multiple archives in Puerto Rico, the United States and England. The authors treat the fluid meanings of the examined historical encounters from a research perspective that privilege complex reciprocal interactions, multiple adaptations and elaborate sociocultural constructs present in a collaborative exemplar of the modernity of medical science in a neocolonial tropical context.

Beam Characterisation of the Australian Synchrotron Imaging and medical beamline for microbeam radiotherapy research

International Nuclear Information System (INIS)

Gagliardi, F.M.; Midgley, S.; Lewis, R.A.; Ackerly, T.L.

2010-01-01

Full text: Microbeam radiotherapy (MRT) has been developed at synchrotrons around the world over the last two decades. Previous studies have shown normal tissue to be extremely tolerant to MRT at doses normally considered toxic in conventional radiotherapy whilst having a palliative and even curative effect on animal tumours. Our MRT research team has attempted to characterise the beam spectrum of the imaging and medical beamline (TMBL) at the Australian Synchrotron. We also carried out film dosimetry to quantify the peak-to-valley dose ratio for three fixed geometry MRT collimators. The source of X-rays on the IMBL is a 1.4 T wiggler at a distance of 20 m from the sample stage. In vacuo and in-air metal absorbers were used to remove soft X-rays hardening the beam to between 30 and 160 keY. Filters used were 1.5 mm C, 2.5 mm AI, 0.5 mm Be and 0.75 mm Cu. Free air ion chamber measurements and half value layer measurements in conjunction with predictions from a theoretical model based upon a spectrum calculator derived a mean energy of the microbeam of 57 keV with a half value layer of approximately 0.29 mm Cu. The measured air kerma rate was 120 Gy/s. Measurements of the MRT beams created with tungsten/kapton multi-slit collimators on radiographic films were compared with Monte Carlo simulations of the microbeam arrays. The peak-to-valley-dose ratios were found to be 3-4 times lower than predicted by the Monte Carlo model. Imperfections in the manufacturing of the collimators may explain the observed discrepancy. (author)

MeV He microbeam analysis of a semiconductor integrated circuit

International Nuclear Information System (INIS)

Zhu Peiran; Liu Jiarui; Zhang Jinping; Yin Shiduan

1989-01-01

An MeV He + microbeam has been used to analyse a microscale semiconductor structure. The 2 MeV He + ion beam is limited to 25 μm diameter by a set of diaphragms and is further focused by a quadrupole quadruplet to 3μm diameter. The incident beam current on the sample is about 0.3 nA. The Rutherford backscattering (RBS) technique is applied to the measurement of the composition and depth profile in the near-surface region of a semiconductor integrated circuit. (author)

MeV He microbeam analysis of a semiconductor integrated circuit

Energy Technology Data Exchange (ETDEWEB)

Zhu Peiran; Liu Jiarui; Zhang Jinping; Yin Shiduan

1989-01-01

An MeV He/sup +/ microbeam has been used to analyse a microscale semiconductor structure. The 2 MeV He/sup +/ ion beam is limited to 25 /mu/m diameter by a set of diaphragms and is further focused by a quadrupole quadruplet to 3/mu/m diameter. The incident beam current on the sample is about 0.3 nA. The Rutherford backscattering (RBS) technique is applied to the measurement of the composition and depth profile in the near-surface region of a semiconductor integrated circuit.

An automated single ion hit at JAERI heavy ion microbeam to observe individual radiation damage

International Nuclear Information System (INIS)

Kamiya, Tomihiro; Sakai, Takuro; Naitoh, Yutaka; Hamano, Tsuyoshi; Hirao, Toshio

1999-01-01

Microbeam scanning and a single ion hit technique have been combined to establish an automated beam positioning and single ion hit system at the JAERI Takasaki heavy ion microbeam system. Single ion irradiation on preset points of a sample in various patterns can be performed automatically in a short period. The reliability of the system was demonstrated using CR-39 nuclear track detectors. Single ion hit patterns were achieved with a positioning accuracy of 2 μm or less. In measurement of single event transient current using this system, the reduction of the pulse height by accumulation of radiation damages was observed by single ion injection to the same local areas. This technique showed a possibility to get some quantitative information about the lateral displacement of an individual radiation effect in silicon PIN photodiodes. This paper will give details of the irradiation system and present results from several experiments

Correlated microradiography, X-ray microbeam diffraction and electron probe microanalysis of calcifications in an odontoma

International Nuclear Information System (INIS)

Aoba, T.; Yoshioka, C.; Yagi, T.

1980-01-01

Using microradiography, X-ray microbeam diffraction and electron probe microanalysis, a correlated morphologic and crystallographic study was performed on dysplastic enamel in a compound odontoma. The tumor was found in the lateral incisor-canine region of the left mandible of a 36-year-old woman. A conspicuous feature was the presence of hypomineralized areas, which were situated in the proximity of enamel surface and distinctly demarcated from the adjacent enamel. X-ray microbeam diffraction and electron microanalysis showed that these lesions have a lower crystallinity and a higher concentration of magnesium as compared with the adjacent enamel. In addition, the present study revealed the presence of two other types of calcifications: 1) calcified structures within the fissure or on the enamel surface, which include lacunae of varying size and which resemble a form of coronal cementum, and 2) spherical calcifications which may be an epithelial product. (author)

Investigation of chemical vapour deposition diamond detectors by X-ray micro-beam induced current and X-ray micro-beam induced luminescence techniques

International Nuclear Information System (INIS)

Olivero, P.; Manfredotti, C.; Vittone, E.; Fizzotti, F.; Paolini, C.; Lo Giudice, A.; Barrett, R.; Tucoulou, R.

2004-01-01

Tracking detectors have become an important ingredient in high-energy physics experiments. In order to survive the harsh detection environment of the large hadron collider (LHC), trackers need to have special properties. They must be radiation hard, provide fast collection of charge, be as thin as possible and remove heat from readout electronics. The unique properties of diamond allow it to fulfill these requirements. In this work we present an investigation of the charge transport and luminescence properties of 'detector grade' artificial chemical vapour deposition (CVD) diamond devices developed within the CERN RD42 collaboration, performed by means of X-ray micro-beam induced current collection (XBICC) and X-ray micro-beam induced luminescence (XBIL) techniques. XBICC technique allows quantitative estimates of the transport parameters of the material to be evaluated and mapped with micrometric spatial resolution. In particular, the high resolution and sensitivity of the technique has allowed a quantitative study of the inhomogeneity of the charge transport parameter defined as the product of mobility and lifetime for both electron and holes. XBIL represents a technique complementary to ion beam induced luminescence (IBIL), which has already been used by our group, since X-ray energy loss profile in the material is different from that of MeV ions. X-ray induced luminescence maps have been performed simultaneously with induced photocurrent maps, to correlate charge transport and induced luminescence properties of diamond. Simultaneous XBICC and XBIL maps exhibit features of partial complementarity that have been interpreted on the basis of considerations on radiative and non-radiative recombination processes which compete with charge transport efficiency

Operating characteristics of the Columbia University α-μ beam

International Nuclear Information System (INIS)

Randers-Pehrson, G.

1994-01-01

The authors have constructed and are now operating an external alpha particle microbeam in a single ion mode for the study of radiation damage to living mammalian cells. Their objective is to understand the biological effects of radon-daughter exposures in the environment. The alpha particle beam is produced by accelerating helium ions with a 4.2 MV Van de Graaff. The beam is directed vertically through the floor of a biology laboratory and into a vibration-isolated microscope. The beam is collimated to a diameter of 6 micrometers by a pair of laser-drilled apertures mounted on a goniometric alignment fixture immediately below the microscope stage. A laser beam used to optically locate the beam also passes through the apertures. Cells growing on thin-bottomed petri dishes are treated with a nuclear stain and illuminated with UV light. The cell nuclei are observed with a microscope fitted with an image intensifier and CCD camera which feeds a PC-based frame grabber and commercial video analysis system. The analysis program is used to locate cellnuclei on the culture dish and then to communicate with an in-house program that controls the microscope stage. This latter program visits each cell in turn and, after final positioning by the operator using a joy stick, a chosen small number of alpha particles are allowed to penetrate the cell nucleus. The alpha particles are detected after passing through the cells by a gas proportional counter mounted on the microscope objective. Observation of the cells and the irradiation are simultaneous. The system presently requires about two minutes to locate the cells on the dish and then about five seconds per cell to visit and irradiate each one. Technical details concerning each of the subsystems in the apparatus and representative biological data will be presented

Status report : British Columbia`s economic plan

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-01-01

A sector-by-sector update of actions taken under British Columbia`s three-year economic plan is outlined and the progress to date reviewed. The three year plan includes the support for industry growth in partnership with the private sector, making Vancouver a major international conference destination, and developing Vancouver International Airport into a major gateway to the Pacific. The plan also includes the promotion of adventure tourism in major international markets, and promoting aboriginal tourism and culture. The government also plans to stimulate the economy by providing $973 million in tax reductions for BC families and business. 1 tab.

On using the dynamic snap-through motion of MEMS initially curved microbeams for filtering applications

KAUST Repository

Ouakad, Hassen M.; Younis, Mohammad I.

2014-01-01

Numerical and experimental investigations of the dynamics of micromachined shallow arches (initially curved microbeams) and the possibility of using their dynamic snap-through motion for filtering purposes are presented. The considered MEMS arches are actuated by a DC electrostatic load along with an AC harmonic load. Their dynamics is examined numerically using a Galerkin-based reduced-order model when excited near both their first and third natural frequencies. Several simulation results are presented demonstrating interesting jumps and dynamic snap-through behavior of the MEMS arches and their attractive features for uses as band-pass filters, such as their sharp roll-off from pass-bands to stop-bands and their flat response. Experimental work is conducted to test arches realized of curved polysilicon microbeams when excited by DC and AC loads. Experimental data of the micromachined curved beams are shown for the softening and hardening behavior near the first and third natural frequencies, respectively, as well as dynamic snap-through motion. © 2013 Elsevier Ltd.

Large deformation of uniaxially loaded slender microbeams on the basis of modified couple stress theory: Analytical solution and Galerkin-based method

Science.gov (United States)

Kiani, Keivan

2017-09-01

Large deformation regime of micro-scale slender beam-like structures subjected to axially pointed loads is of high interest to nanotechnologists and applied mechanics community. Herein, size-dependent nonlinear governing equations are derived by employing modified couple stress theory. Under various boundary conditions, analytical relations between axially applied loads and deformations are presented. Additionally, a novel Galerkin-based assumed mode method (AMM) is established to solve the highly nonlinear equations. In some particular cases, the predicted results by the analytical approach are also checked with those of AMM and a reasonably good agreement is reported. Subsequently, the key role of the material length scale on the load-deformation of microbeams is discussed and the deficiencies of the classical elasticity theory in predicting such a crucial mechanical behavior are explained in some detail. The influences of slenderness ratio and thickness of the microbeam on the obtained results are also examined. The present work could be considered as a pivotal step in better realizing the postbuckling behavior of nano-/micro- electro-mechanical systems consist of microbeams.

In situ macromolecular crystallography using microbeams.

Science.gov (United States)

Axford, Danny; Owen, Robin L; Aishima, Jun; Foadi, James; Morgan, Ann W; Robinson, James I; Nettleship, Joanne E; Owens, Raymond J; Moraes, Isabel; Fry, Elizabeth E; Grimes, Jonathan M; Harlos, Karl; Kotecha, Abhay; Ren, Jingshan; Sutton, Geoff; Walter, Thomas S; Stuart, David I; Evans, Gwyndaf

2012-05-01

Despite significant progress in high-throughput methods in macromolecular crystallography, the production of diffraction-quality crystals remains a major bottleneck. By recording diffraction in situ from crystals in their crystallization plates at room temperature, a number of problems associated with crystal handling and cryoprotection can be side-stepped. Using a dedicated goniometer installed on the microfocus macromolecular crystallography beamline I24 at Diamond Light Source, crystals have been studied in situ with an intense and flexible microfocus beam, allowing weakly diffracting samples to be assessed without a manual crystal-handling step but with good signal to noise, despite the background scatter from the plate. A number of case studies are reported: the structure solution of bovine enterovirus 2, crystallization screening of membrane proteins and complexes, and structure solution from crystallization hits produced via a high-throughput pipeline. These demonstrate the potential for in situ data collection and structure solution with microbeams. © 2012 International Union of Crystallography

Characterization and quantification of cerebral edema induced by synchrotron x-ray microbeam radiation therapy

Energy Technology Data Exchange (ETDEWEB)

Serduc, Raphael; Looij, Yohan van de; Francony, Gilles; Verdonck, Olivier; Sanden, Boudewijn van der; Farion, Regine; Segebarth, Christoph; Remy, Chantal; Lahrech, Hana [INSERM, U836, F-38043 Grenoble (France); Laissue, Jean [Institute of Pathology, University of Bern (Switzerland); Braeuer-Krisch, Elke; Siegbahn, Erik Albert; Bravin, Alberto; Prezado, Yolanda [European Synchrotron Radiation Facility, F-38043 Grenoble (France)], E-mail: serduc@esrf.fr

2008-03-07

Cerebral edema is one of the main acute complications arising after irradiation of brain tumors. Microbeam radiation therapy (MRT), an innovative experimental radiotherapy technique using spatially fractionated synchrotron x-rays, has been shown to spare radiosensitive tissues such as mammal brains. The aim of this study was to determine if cerebral edema occurs after MRT using diffusion-weighted MRI and microgravimetry. Prone Swiss nude mice's heads were positioned horizontally in the synchrotron x-ray beam and the upper part of the left hemisphere was irradiated in the antero-posterior direction by an array of 18 planar microbeams (25 mm wide, on-center spacing 211 mm, height 4 mm, entrance dose 312 Gy or 1000 Gy). An apparent diffusion coefficient (ADC) was measured at 7 T 1, 7, 14, 21 and 28 days after irradiation. Eventually, the cerebral water content (CWC) was determined by microgravimetry. The ADC and CWC in the irradiated (312 Gy or 1000 Gy) and in the contralateral non-irradiated hemispheres were not significantly different at all measurement times, with two exceptions: (1) a 9% ADC decrease (p < 0.05) was observed in the irradiated cortex 1 day after exposure to 312 Gy, (2) a 0.7% increase (p < 0.05) in the CWC was measured in the irradiated hemispheres 1 day after exposure to 1000 Gy. The results demonstrate the presence of a minor and transient cellular edema (ADC decrease) at 1 day after a 312 Gy exposure, without a significant CWC increase. One day after a 1000 Gy exposure, the CWC increased, while the ADC remained unchanged and may reflect the simultaneous presence of cellular and vasogenic edema. Both types of edema disappear within a week after microbeam exposure which may confirm the normal tissue sparing effect of MRT. For more information on this article, see medicalphysicsweb.org.

Identification of ancient textile fibres from Khirbet Qumran caves using synchrotron radiation microbeam diffraction

Energy Technology Data Exchange (ETDEWEB)

Mueller, Martin [Institut fuer Experimentelle und Angewandte Physik der Christian, Albrechts, Universitaet zu Kiel, Leibnizstr. 19, D-24098 Kiel (Germany)]. E-mail: mmueller@physik.uni-kiel.de; Murphy, Bridget [Institut fuer Experimentelle und Angewandte Physik der Christian, Albrechts, Universitaet zu Kiel, Leibnizstr. 19, D-24098 Kiel (Germany); Burghammer, Manfred [European Synchrotron Radiation Facility, B.P. 220, F-38043 Grenoble Cedex (France); Riekel, Christian [European Synchrotron Radiation Facility, B.P. 220, F-38043 Grenoble Cedex (France); Roberts, Mark [Daresbury Laboratory, Keckwick Lane, Warrington WA4 4AD (United Kingdom); Papiz, Miroslav [Daresbury Laboratory, Keckwick Lane, Warrington WA4 4AD (United Kingdom); Clarke, David [Daresbury Laboratory, Keckwick Lane, Warrington WA4 4AD (United Kingdom); Gunneweg, Jan [Institute of Archaeology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem (Israel); Pantos, Emmanuel [Daresbury Laboratory, Keckwick Lane, Warrington WA4 4AD (United Kingdom)

2004-10-08

Archaeological textiles fragments from the caves of Qumran in the Dead Sea region were investigated by means of X-ray microbeam diffraction on single fibres. This non-destructive technique made the identification of the used plant textile fibres possible. Apart from bast fibres (mainly flax), cotton was identified which was most unexpected in the archaeological context.

Identification of ancient textile fibres from Khirbet Qumran caves using synchrotron radiation microbeam diffraction

International Nuclear Information System (INIS)

Mueller, Martin; Murphy, Bridget; Burghammer, Manfred; Riekel, Christian; Roberts, Mark; Papiz, Miroslav; Clarke, David; Gunneweg, Jan; Pantos, Emmanuel

2004-01-01

Archaeological textiles fragments from the caves of Qumran in the Dead Sea region were investigated by means of X-ray microbeam diffraction on single fibres. This non-destructive technique made the identification of the used plant textile fibres possible. Apart from bast fibres (mainly flax), cotton was identified which was most unexpected in the archaeological context

Identification of ancient textile fibres from Khirbet Qumran caves using synchrotron radiation microbeam diffraction

Science.gov (United States)

Müller, Martin; Murphy, Bridget; Burghammer, Manfred; Riekel, Christian; Roberts, Mark; Papiz, Miroslav; Clarke, David; Gunneweg, Jan; Pantos, Emmanuel

2004-10-01

Archaeological textiles fragments from the caves of Qumran in the Dead Sea region were investigated by means of X-ray microbeam diffraction on single fibres. This non-destructive technique made the identification of the used plant textile fibres possible. Apart from bast fibres (mainly flax), cotton was identified which was most unexpected in the archaeological context.

EDITORIAL: Selected articles from `The 8th Edoardo Amaldi Conference on Gravitational Waves (Amaldi 8)', Columbia University, New York, 22-26 June 2009 Selected articles from `The 8th Edoardo Amaldi Conference on Gravitational Waves (Amaldi 8)', Columbia University, New York, 22-26 June 2009

Science.gov (United States)

Marka, Zsuzsa; Marka, Szabolcs

2010-04-01

At Amaldi7,which was held in Sydney in 2007, the Gravitational Wave International Committee (GWIC), which oversees the Amaldi meetings, decided to hold the 8th Edoardo Amaldi Conference on Gravitational Waves at Columbia University in the City of New York. With this decision, Amaldi returned to North America after a decade. The previous two years have seen many advances in the field of gravitational-wave detection. By the summer of 2009 the km-scale ground based interferometric detectors in the USA and Europe were preparing for a second long-term scientific run as a worldwide detector network. The advanced or second-generation detectors had well-developed plans and were ready for the production phase or had started construction. The European-American space mission, LISA Pathfinder, is progressing towards deployment in the foreseeable future and it is expected to pave the way towards gravitational-wave detection in the millihertz regime with LISA. Plans were developed for an additional gravitational-wave detector in Australia and in Japan (in this case underground) to extend the worldwide network of detectors for the advanced detector era. Japanese colleagues also presented plans for a space mission, DECIGO, that would bridge the gap between the LISA and ground-based interferometer frequency range. Compared to previous Amaldi meetings, Amaldi8 had new elements representing emerging trends in the field. For example, with the inclusion of pulsar timing collaborations to the GWIC, gravitational-wave detection using pulsar timing arrays was recognized as one of the prominent directions in the field and was represented at Amaldi8 as a separate session. By 2009, searches for gravitational waves based on external triggers received from electromagnetic observations were already producing significant scientific results and plans existed for pointing telescopes by utilizing gravitational-wave trigger events. Such multimessenger approaches to gravitational-wave detection also

An Electrically Actuated Microbeam-Based MEMS Device: Experimental and Theoretical Investigation

KAUST Repository

Ruzziconi, Laura

2017-11-03

The present paper deals with the dynamic behavior of a microelectromechanical systems (MEMS). The device consists of a clamped-clamped microbeam electrostatically and electrodynamically actuated. Our objective is to develop a theoretical analysis, which is able to describe and predict all the main relevant aspects of the experimental response. In the first part of the paper an extensive experimental investigation is conducted. The microbeam is perfectly straight. The first three experimental natural frequencies are identified and the nonlinear dynamics are explored at increasing values of electrodynamic excitation. Several backward and forward frequency sweeps are acquired. The nonlinear behavior is highlighted. The experimental data show the coexistence of the nonresonant and the resonant branch, which perform a bending toward higher frequencies values before undergoing jump or pull-in dynamics. This kind of bending is not particularly common in MEMS. In the second part of the paper, a theoretical single degree-of-freedom model is derived. The unknown parameters are extracted and settled via parametric identification. A single mode reduced-order model is considered, which is obtained via the Galerkin technique. To enhance the computational efficiency, the contribution of the electric force term is computed in advance and stored in a table. Extensive numerical simulations are performed at increasing values of electrodynamic excitation. They are observed to properly predict all the main nonlinear features arising in the device response. This occurs not only at low values of electrodynamic excitation, but also at higher ones

Laser microbeams for the manipulation of plant cells and subcellular structures

International Nuclear Information System (INIS)

Hoffmann, F.

1996-01-01

Laser microsurgery has been used in plants to study physiological, cell biological and genetical questions for over 10 years. More recently, the optical trap became available as an additional tool. Specific areas of research include membrane physiology, motility, transformation and protoplast fusion. Compared to the data reported in animal systems, the contributions of laser microbeam manipulations in plant biology are rather limited. However, with increased awareness of the enormous potential of the technology and better accessibility to less expensive and more user-friendly equipment, the next decade should be more productive. (author)

Effects of locally targeted heavy-ion and laser microbeam on root hydrotropism in Arabidopsis thaliana

International Nuclear Information System (INIS)

Miyazawa, Yutaka; Sakashita, Tetsuya; Funayama, Tomoo

2008-01-01

Classical studies on root hydrotropism have hypothesized the importance of columella cells as well as the de novo gene expression, such as auxin-inducible gene, at the elongation zone in hydrotropism; however, there has been no confirmation that columella cells or auxin-mediated signaling in the elongation zone are necessary for hydrotropism. We examined the role of root cap and elongation zone cells in root hydrotropism using heavy-ion and laser microbeam. Heavy-ion microbeam irradiation of the elongation zone, but not that of the columella cells, significantly and temporarily suppressed the development of hydrotropic curvature. However, laser ablation confirmed that columella cells are indispensable for hydrotropism. Systemic heavy-ion broad-beam irradiation suppressed de novo expression of INDOLE ACETIC ACID 5 gene, but not MIZU-KUSSEI1 gene. Our results indicate that both the root cap and elongation zone have indispensable and functionally distinct roles in root hydrotropism, and that de novo gene expression might be required for hydrotropism in the elongation zone, but not in columella cells. (author)

Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation

International Nuclear Information System (INIS)

Belyakov, O.V.; Folkard, M.; Mothersill, C.; Prise, K.M.; Michael, B.D.

2002-01-01

The ureter primary explant technique was developed to study bystander effects under in vivo like conditions where stem and differentiated cells are present. Irradiation was performed with a 3 He 2+ charged particle microbeam available at the Gray Cancer Institute, with high (∼2 μm) precision. Tissue sections from porcine ureters were pre-irradiated with the microbeam at a single location with 10 3 He 2+ particles (5 MeV; LET 70 keV.μm -1 ). After irradiation, the tissue section was incubated for 7 days, thus allowing the explant outgrowth to form. Total cellular damage (total fraction of micronucleated and apoptotic cells) was measured according to morphological criteria. Apoptosis was also assessed using a 3'-OH DNA end-labelling technique. Premature differentiation was estimated using antibodies to uroplakin III, a specific marker of terminal urothelial differentiation. Results of our experiments demonstrated a significant bystander-induced differentiation and a less significant increase in apoptotic and micronucleated cells. A hypothesis based on the protective nature of the bystander effect is proposed. (author)

Studying nanostructure gradients in injection-molded polypropylene/montmorillonite composites by microbeam small-angle x-ray scattering

DEFF Research Database (Denmark)

Stribeck, Norbert; Schneider, Konrad; Zeinolebadi, Ahmad

2014-01-01

The core–shell structure in oriented cylindrical rods of polypropylene (PP) and nanoclay composites (NCs) from PP and montmorillonite (MMT) is studied by microbeam small-angle x-ray scattering (SAXS). The structure of neat PP is almost homogeneous across the rod showing regular semicrystalline......-shaped phyllosilicate filler particles....

Mechanical analysis of non-uniform bi-directional functionally graded intelligent micro-beams using modified couple stress theory

Science.gov (United States)

Bakhshi Khaniki, Hossein; Rajasekaran, Sundaramoorthy

2018-05-01

This study develops a comprehensive investigation on mechanical behavior of non-uniform bi-directional functionally graded beam sensors in the framework of modified couple stress theory. Material variation is modelled through both length and thickness directions using power-law, sigmoid and exponential functions. Moreover, beam is assumed with linear, exponential and parabolic cross-section variation through the length using power-law and sigmoid varying functions. Using these assumptions, a general model for microbeams is presented and formulated by employing Hamilton’s principle. Governing equations are solved using a mixed finite element method with Lagrangian interpolation technique, Gaussian quadrature method and Wilson’s Lagrangian multiplier method. It is shown that by using bi-directional functionally graded materials in nonuniform microbeams, mechanical behavior of such structures could be affected noticeably and scale parameter has a significant effect in changing the rigidity of nonuniform bi-directional functionally graded beams.

A Microbeam Small-Angle X-ray Scattering Study on Enamel Crystallites in Subsurface Lesion

Energy Technology Data Exchange (ETDEWEB)

Yagi, N; Ohta, N; Matsuo, T [Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo, Hyogo 679-5198 (Japan); Tanaka, T; Terada, Y; Kamasaka, H; Kometani, T, E-mail: yagi@spring8.or.j [Ezaki Glico Co. Ltd., 4-6-5 Utajima, Nishiyodogawa-ku, Osaka 555-8502 (Japan)

2010-10-01

The early caries lesion in bovine tooth enamel was studied by two different X-ray diffraction systems at the SPring-8 third generation synchrotron radiation facility. Both allowed us simultaneous measurement of the small and large angle regions. The beam size was 6{mu}m at BL40XU and 50{mu}m at BL45XU. The small-angle scattering from voids in the hydroxyapatite crystallites and the wide-angle diffraction from the hydroxyapatite crystals were observed simultaneously. At BL40XU an X-ray image intensifier was used for the small-angle and a CMOS flatpanel detector for the large-angle region. At BL45XU, a large-area CCD detector was used to cover both regions. A linear microbeam scan at BL40XU showed a detailed distribution of voids and crystals and made it possible to examine the structural details in the lesion. The two-dimensional scan at BL45XU showed distribution of voids and crystals in a wider region in the enamel. The simultaneous small- and wide-angle measurement with a microbeam is a powerful tool to elucidate the mechanisms of demineralization and remineralization in the early caries lesion.

A Microbeam Small-Angle X-ray Scattering Study on Enamel Crystallites in Subsurface Lesion

International Nuclear Information System (INIS)

Yagi, N; Ohta, N; Matsuo, T; Tanaka, T; Terada, Y; Kamasaka, H; Kometani, T

2010-01-01

The early caries lesion in bovine tooth enamel was studied by two different X-ray diffraction systems at the SPring-8 third generation synchrotron radiation facility. Both allowed us simultaneous measurement of the small and large angle regions. The beam size was 6μm at BL40XU and 50μm at BL45XU. The small-angle scattering from voids in the hydroxyapatite crystallites and the wide-angle diffraction from the hydroxyapatite crystals were observed simultaneously. At BL40XU an X-ray image intensifier was used for the small-angle and a CMOS flatpanel detector for the large-angle region. At BL45XU, a large-area CCD detector was used to cover both regions. A linear microbeam scan at BL40XU showed a detailed distribution of voids and crystals and made it possible to examine the structural details in the lesion. The two-dimensional scan at BL45XU showed distribution of voids and crystals in a wider region in the enamel. The simultaneous small- and wide-angle measurement with a microbeam is a powerful tool to elucidate the mechanisms of demineralization and remineralization in the early caries lesion.

In situ macromolecular crystallography using microbeams

International Nuclear Information System (INIS)

Axford, Danny; Owen, Robin L.; Aishima, Jun; Foadi, James; Morgan, Ann W.; Robinson, James I.; Nettleship, Joanne E.; Owens, Raymond J.; Moraes, Isabel; Fry, Elizabeth E.; Grimes, Jonathan M.; Harlos, Karl; Kotecha, Abhay; Ren, Jingshan; Sutton, Geoff; Walter, Thomas S.; Stuart, David I.; Evans, Gwyndaf

2012-01-01

A sample environment for mounting crystallization trays has been developed on the microfocus beamline I24 at Diamond Light Source. The technical developments and several case studies are described. Despite significant progress in high-throughput methods in macromolecular crystallography, the production of diffraction-quality crystals remains a major bottleneck. By recording diffraction in situ from crystals in their crystallization plates at room temperature, a number of problems associated with crystal handling and cryoprotection can be side-stepped. Using a dedicated goniometer installed on the microfocus macromolecular crystallography beamline I24 at Diamond Light Source, crystals have been studied in situ with an intense and flexible microfocus beam, allowing weakly diffracting samples to be assessed without a manual crystal-handling step but with good signal to noise, despite the background scatter from the plate. A number of case studies are reported: the structure solution of bovine enterovirus 2, crystallization screening of membrane proteins and complexes, and structure solution from crystallization hits produced via a high-throughput pipeline. These demonstrate the potential for in situ data collection and structure solution with microbeams

Negative Knudsen force on heated microbeams

KAUST Repository

Zhu, Taishan

2011-11-18

Knudsen force acting on a heated microbeam adjacent to a cold substrate in a rarefied gas is a mechanical force created by unbalanced thermal gradients. The measured force has its direction pointing towards the side with a lower thermal gradient and its magnitude vanishes in both continuum and free-molecule limits. In our previous study, negative Knudsen forces were discovered at the high Knudsen regime before diminishing in the free-molecule limit. Such a phenomenon was, however, neither observed in experiment [A. Passian et al., Phys. Rev. Lett. 90, 124503 (2003)], nor captured in the latest numerical study [J. Nabeth et al., Phys. Rev. E 83, 066306 (2011)]. In this paper, the existence of such a negative Knudsen force is further confirmed using both numerical simulation and theoretical analysis. The asymptotic order of the Knudsen force near the collisionless limit is analyzed and the analytical expression of its leading term is provided, from which approaches for the enhancement of negative Knudsen forces are proposed. The discovered phenomenon could find its applications in novel mechanisms for pressure sensing and actuation.

In situ macromolecular crystallography using microbeams

Energy Technology Data Exchange (ETDEWEB)

Axford, Danny; Owen, Robin L.; Aishima, Jun [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom); Foadi, James [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom); Imperial College, London SW7 2AZ (United Kingdom); Morgan, Ann W.; Robinson, James I. [University of Leeds, Leeds LS9 7FT (United Kingdom); Nettleship, Joanne E.; Owens, Raymond J. [Research Complex at Harwell, Rutherford Appleton Laboratory R92, Didcot, Oxfordshire OX11 0DE (United Kingdom); Moraes, Isabel [Imperial College, London SW7 2AZ (United Kingdom); Fry, Elizabeth E.; Grimes, Jonathan M.; Harlos, Karl; Kotecha, Abhay; Ren, Jingshan; Sutton, Geoff; Walter, Thomas S. [University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Stuart, David I. [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom); University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Evans, Gwyndaf, E-mail: gwyndaf.evans@diamond.ac.uk [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom)

2012-04-17

A sample environment for mounting crystallization trays has been developed on the microfocus beamline I24 at Diamond Light Source. The technical developments and several case studies are described. Despite significant progress in high-throughput methods in macromolecular crystallography, the production of diffraction-quality crystals remains a major bottleneck. By recording diffraction in situ from crystals in their crystallization plates at room temperature, a number of problems associated with crystal handling and cryoprotection can be side-stepped. Using a dedicated goniometer installed on the microfocus macromolecular crystallography beamline I24 at Diamond Light Source, crystals have been studied in situ with an intense and flexible microfocus beam, allowing weakly diffracting samples to be assessed without a manual crystal-handling step but with good signal to noise, despite the background scatter from the plate. A number of case studies are reported: the structure solution of bovine enterovirus 2, crystallization screening of membrane proteins and complexes, and structure solution from crystallization hits produced via a high-throughput pipeline. These demonstrate the potential for in situ data collection and structure solution with microbeams.

Characterization of arsenic-contaminated aquifer sediments from eastern Croatia by ion microbeam, PIXE and ICP-OES techniques

Energy Technology Data Exchange (ETDEWEB)

Ujević Bošnjak, M., E-mail: magdalena.ujevic@hzjz.hr [Croatian National Institute of Public Health, Rockefelerova 7, 10000 Zagreb (Croatia); Fazinić, S. [Institute Ruđer Bošković, Bijenička cesta, 10000 Zagreb (Croatia); Duić, Ž. [University of Zagreb, Faculty of Mining, Geology and Petroleum Engineering, Pierottijeva 6, Zagreb (Croatia)

2013-10-01

Highlights: •ICP-OES and PIXE used in the characterization of As-contaminated sediments. •Observed high correlations between the results obtained by those techniques. •Discrepancies observed for Mn, and for the highest As concentrations. •Microbeam analyses showed As association with sulphides and iron. -- Abstract: Groundwater arsenic contamination has been evidenced in eastern Croatia and hydrochemical results suggest that the occurrence of arsenic in the groundwater depends on the local geology, hydrogeology, and geochemical characteristics of the aquifer. In order to perform the sediment characterization and to investigate arsenic association with the other elements in the sediments, 10 samples from two boreholes (PVc-3 and Gundinci 1) in eastern Croatia were analyzed using two techniques: PIXE (without sample pre-treatment) and ICP-OES (after digestion), as well by ion microbeam analyses. The results of the PIXE and ICP-OES techniques showed quite good agreement; however, greater discrepancies were observed at the higher arsenic and manganese mass ratios. According to both techniques, higher As mass ratios were observed in the sediments from the PVc-3 core (up to 651 mg/kg and 491 mg/kg using PIXE and ICP-OES analyses respectively) than from the Gundinci 1 core (up to 60 mg/kg using both techniques). Although arsenic association with Fe is expected, no correlation was observed. The microbeam analyses demonstrated that arsenic is associated with sulphides and iron in the most As-contaminated sample from the PVc-3 core, while this relationship was not evident in the most As-contaminated sample from the Gundinci 1 borehole.

Characterization of arsenic-contaminated aquifer sediments from eastern Croatia by ion microbeam, PIXE and ICP-OES techniques

International Nuclear Information System (INIS)

Ujević Bošnjak, M.; Fazinić, S.; Duić, Ž.

2013-01-01

Highlights: •ICP-OES and PIXE used in the characterization of As-contaminated sediments. •Observed high correlations between the results obtained by those techniques. •Discrepancies observed for Mn, and for the highest As concentrations. •Microbeam analyses showed As association with sulphides and iron. -- Abstract: Groundwater arsenic contamination has been evidenced in eastern Croatia and hydrochemical results suggest that the occurrence of arsenic in the groundwater depends on the local geology, hydrogeology, and geochemical characteristics of the aquifer. In order to perform the sediment characterization and to investigate arsenic association with the other elements in the sediments, 10 samples from two boreholes (PVc-3 and Gundinci 1) in eastern Croatia were analyzed using two techniques: PIXE (without sample pre-treatment) and ICP-OES (after digestion), as well by ion microbeam analyses. The results of the PIXE and ICP-OES techniques showed quite good agreement; however, greater discrepancies were observed at the higher arsenic and manganese mass ratios. According to both techniques, higher As mass ratios were observed in the sediments from the PVc-3 core (up to 651 mg/kg and 491 mg/kg using PIXE and ICP-OES analyses respectively) than from the Gundinci 1 core (up to 60 mg/kg using both techniques). Although arsenic association with Fe is expected, no correlation was observed. The microbeam analyses demonstrated that arsenic is associated with sulphides and iron in the most As-contaminated sample from the PVc-3 core, while this relationship was not evident in the most As-contaminated sample from the Gundinci 1 borehole

Analysis of strain error sources in micro-beam Laue diffraction

International Nuclear Information System (INIS)

Hofmann, Felix; Eve, Sophie; Belnoue, Jonathan; Micha, Jean-Sébastien; Korsunsky, Alexander M.

2011-01-01

Micro-beam Laue diffraction is an experimental method that allows the measurement of local lattice orientation and elastic strain within individual grains of engineering alloys, ceramics, and other polycrystalline materials. Unlike other analytical techniques, e.g. based on electron microscopy, it is not limited to surface characterisation or thin sections, but rather allows non-destructive measurements in the material bulk. This is of particular importance for in situ loading experiments where the mechanical response of a material volume (rather than just surface) is studied and it is vital that no perturbation/disturbance is introduced by the measurement technique. Whilst the technique allows lattice orientation to be determined to a high level of precision, accurate measurement of elastic strains and estimating the errors involved is a significant challenge. We propose a simulation-based approach to assess the elastic strain errors that arise from geometrical perturbations of the experimental setup. Using an empirical combination rule, the contributions of different geometrical uncertainties to the overall experimental strain error are estimated. This approach was applied to the micro-beam Laue diffraction setup at beamline BM32 at the European Synchrotron Radiation Facility (ESRF). Using a highly perfect germanium single crystal, the mechanical stability of the instrument was determined and hence the expected strain errors predicted. Comparison with the actual strain errors found in a silicon four-point beam bending test showed good agreement. The simulation-based error analysis approach makes it possible to understand the origins of the experimental strain errors and thus allows a directed improvement of the experimental geometry to maximise the benefit in terms of strain accuracy.

PREFACE: EMAS 2011: 12th European Workshop on Modern Developments in Microbeam Analysis

Science.gov (United States)

Brisset, François; Dugne, Olivier; Robaut, Florence; Lábár, János L.; Walker, Clive T.

2012-03-01

This volume of IOP Conference Series: Materials Science and Engineering contains papers from the 12th Workshop of the European Microbeam Analysis Society (EMAS) on Modern Developments and Applications in Microbeam Analysis, which took place from the 15-19 May 2011 in the Angers Congress Centre, Angers, France. The primary aim of this series of workshops is to assess the state-of-the-art and reliability of microbeam analysis techniques. The workshops also provide a forum where students and young scientists starting out on a career in microbeam analysis can meet and discuss with the established experts. The workshops have a very specific format comprising invited plenary lectures by internationally recognized experts, poster presentations by the participants and round table discussions on the key topics led by specialists in the field. This workshop was organized in collaboration with GN-MEBA - Groupement National de Microscopie Electronique à Balayage et de microAnalysis, France. The technical programme included the following topics: the limits of EPMA, new techniques, developments and concepts in microanalysis, microanalysis in the SEM, and new and less common applications of micro- and nanoanalysis. As at previous workshops there was also a special oral session for young scientists. The best presentation by a young scientist was awarded with an invitation to attend the 2012 Microscopy and Microanalysis meeting at Phoenix, Arizona. The prize went to Pierre Burdet, of the Federal Institute of Technology of Lausanne (EPFL), for his talk entitled '3D EDS microanalysis by FIB-SEM: enhancement of elemental quantification'. The continuing relevance of the EMAS workshops and the high regard in which they are held internationally can be seen from the fact that 74 posters from 18 countries were on display at the meeting, and that the participants came from as far away as Japan, Canada and the USA. A selection of participants with posters were invited to give a short oral

Building Columbia from the SysAdmin View

Science.gov (United States)

Chan, David

2005-01-01

Project Columbia was built at NASA Ames Research Center in partnership with SGI and Intel. Columbia consists of 20 512 processor Altix machines with 440TB of storage and achieved 51.87 TeraPlops to be ranked the second fastest on the top 500 at SuperComputing 2004. Columbia was delivered, installed and put into production in 3 months. On average, a new Columbia node was brought into production in less than a week. Columbia's configuration, installation, and future plans will be discussed.

Building a more diverse biomedical engineering workforce: Biomedical engineering at the university of the district of Columbia, a historically black college & university.

Science.gov (United States)

Thompson, Lara A; Adebayo, A Segun; Nian Zhang; Haghani, Sasan; Dowell, Kathleen; Shetty, Devdas

2016-08-01

Biomedical Engineering (BME) is a new, multidisciplinary, and rapidly growing field, however, the BME Workforce suffers from limited ethnic and gender diversity. Despite the demand and growth of this new field due to its public health importance, only 4 out of the 107 Historically Black Colleges and Universities (HBCUs) nationwide offers a Bachelor's of Science (B.S.) in Bio-Engineering related fields. In order to contribute to a growing BME Workforce, HBCUs need to react and offer more degree-programs relevant to BME. At the University of the District of Columbia (UDC), an HBCU and the District's only public institution for higher learning, we have recently established a new, degree program: Bachelor of Science in Biomedical Engineering (B.S. in BME) full-board approved in Fall 2014, with program activities initiated in Fall 2015. The educational goal of this program is to enhance the quality and diversity of the BME Workforce via student professional development, new and relevant BME courses, and BME scholarly activities (e.g., guest lectures and journal club sessions), ultimately to increase the number of ethnic minorities pursuing careers and degrees in BME. Through our program activities, we are aiming to meet the nation's demand to contribute to a diverse BME workforce, directed towards solving problems in human health. A secondary, but related goal, is to increase the diversity of STEM-related fields. This paper summarizes our initial, but encouraging, BME activity-related findings. However, this study will be longitudinal (on a multiple year time period) to observe the true outcomes of our initiative.

Electrothermally actuated tunable clamped-guided resonant microbeams

Science.gov (United States)

Alcheikh, N.; Hajjaj, A. Z.; Jaber, N.; Younis, M. I.

2018-01-01

We present simulation and experimental investigation demonstrating active alteration of the resonant and frequency response behavior of resonators by controlling the electrothermal actuation method on their anchors. In-plane clamped-guided arch and straight microbeams resonators are designed and fabricated with V-shaped electrothermal actuators on their anchors. These anchors not only offer various electrothermal actuation options, but also serve as various mechanical stiffness elements that affect the operating resonance frequency of the structures. We have shown that for an arch, the first mode resonance frequency can be increased up to 50% of its initial value. For a straight beam, we have shown that before buckling, the resonance frequency decreases to very low values and after buckling, it increases up to twice of its initial value. These results can be promising for the realization of different wide-range tunable microresonator. The experimental results have been compared to multi-physics finite-element simulations showing good agreement among them.

Electrothermally actuated tunable clamped-guided resonant microbeams

KAUST Repository

Alcheikh, Nouha

2017-06-11

We present simulation and experimental investigation demonstrating active alteration of the resonant and frequency response behavior of resonators by controlling the electrothermal actuation method on their anchors. In-plane clamped-guided arch and straight microbeams resonators are designed and fabricated with V-shaped electrothermal actuators on their anchors. These anchors not only offer various electrothermal actuation options, but also serve as various mechanical stiffness elements that affect the operating resonance frequency of the structures. We have shown that for an arch, the first mode resonance frequency can be increased up to 50% of its initial value. For a straight beam, we have shown that before buckling, the resonance frequency decreases to very low values and after buckling, it increases up to twice of its initial value. These results can be promising for the realization of different wide–range tunable microresonator. The experimental results have been compared to multi-physics finite-element simulations showing good agreement among them.

Radiosurgery using heavy ion microbeams for biological study: Fate mapping of the cellular blastoderm-stage egg of the silkworm, Bombyx mori

International Nuclear Information System (INIS)

Kiguchi, Kenji; Shirai, Koji; Kanekatsu, Rensuke; Kobayashi, Yasuhiko; Tu, Z.-L.; Funayama, Tomoo; Watanabe, Hiroshi

2003-01-01

We investigated the effects of heavy ions on embryogenesis of the silkworm, Bombyx mori using a collimated heavy ion microbeam from the vertical beam line of an AVF-cyclotron. Eggs were exposed to carbon ions at the cellular blastoderm stage. Microbeams were found to be extremely useful for radio-microsurgical inactivation of nuclei or cells in the target site. Spot irradiation caused abnormal embryos, which showed localized defects such as deletion, duplication and fusion, depending on dose, beam size and site of irradiation. The location and frequency of defects on the resultant embryos were closely correlated to the irradiation site. Based on this correlation, a fate map was established for the Bombyx egg at the cellular blastoderm stage

Radiosurgery using heavy ion microbeams for biological study: Fate mapping of the cellular blastoderm-stage egg of the silkworm, Bombyx mori

Energy Technology Data Exchange (ETDEWEB)

Kiguchi, Kenji E-mail: kkiguch@giptc.shinshu-u.ac.jp; Shirai, Koji; Kanekatsu, Rensuke; Kobayashi, Yasuhiko; Tu, Z.-L.; Funayama, Tomoo; Watanabe, Hiroshi

2003-09-01

We investigated the effects of heavy ions on embryogenesis of the silkworm, Bombyx mori using a collimated heavy ion microbeam from the vertical beam line of an AVF-cyclotron. Eggs were exposed to carbon ions at the cellular blastoderm stage. Microbeams were found to be extremely useful for radio-microsurgical inactivation of nuclei or cells in the target site. Spot irradiation caused abnormal embryos, which showed localized defects such as deletion, duplication and fusion, depending on dose, beam size and site of irradiation. The location and frequency of defects on the resultant embryos were closely correlated to the irradiation site. Based on this correlation, a fate map was established for the Bombyx egg at the cellular blastoderm stage.

Scanning three-dimensional x-ray diffraction microscopy using a high-energy microbeam

International Nuclear Information System (INIS)

Hayashi, Y.; Hirose, Y.; Seno, Y.

2016-01-01

A scanning three-dimensional X-ray diffraction (3DXRD) microscope apparatus with a high-energy microbeam was installed at the BL33XU Toyota beamline at SPring-8. The size of the 50 keV beam focused using Kirkpatrick-Baez mirrors was 1.3 μm wide and 1.6 μm high in full width at half maximum. The scanning 3DXRD method was tested for a cold-rolled carbon steel sheet sample. A three-dimensional orientation map with 37 "3 voxels was obtained.

Scanning three-dimensional x-ray diffraction microscopy using a high-energy microbeam

Energy Technology Data Exchange (ETDEWEB)

Hayashi, Y., E-mail: y-hayashi@mosk.tytlabs.co.jp; Hirose, Y.; Seno, Y. [Toyota Central R& D Toyota Central R& D Labs., Inc., 41-1 Nagakute Aichi 480-1192 Japan (Japan)

2016-07-27

A scanning three-dimensional X-ray diffraction (3DXRD) microscope apparatus with a high-energy microbeam was installed at the BL33XU Toyota beamline at SPring-8. The size of the 50 keV beam focused using Kirkpatrick-Baez mirrors was 1.3 μm wide and 1.6 μm high in full width at half maximum. The scanning 3DXRD method was tested for a cold-rolled carbon steel sheet sample. A three-dimensional orientation map with 37 {sup 3} voxels was obtained.

The Columbia Earth Institute : designing strategies and providing innovations for the wise stewardship of our planet

International Nuclear Information System (INIS)

Eisenberger, P.

1997-01-01

The view of Columbia University's Earth Institute for meeting the global warming challenge was described. According to this view, the challenges require global engineering, global mitigation and global planning. It was suggested that one way to address the problem is for institutions of higher learning to become aware that the different systems in the world are very connected and affect each other more than previously thought. Physical sciences, such as chemistry and physics, and the ecological or biological sciences should be portrayed as connected disciplines. Our understanding of nature depends on a balanced view between hard sciences and social sciences, yet students are rarely exposed to both. The Earth Institute at Columbia University is trying to break down the disciplinary boundaries within the university in an effort to better understand the interactions between the different systems and to come up with a comprehensive, 'from science-to-policy' perspective

Scanning ion micro-beam techniques for measuring diffusion in heterogeneous materials

International Nuclear Information System (INIS)

Jenneson, P.M.; Clough, A.S.

1998-01-01

A raster scanning MeV micro-beam of 1 H + or 3 He + ions was used to study the diffusion of small molecules in heterogeneous materials. The location of elemental contaminants (heavier than Lithium) in polymer insulated cables was studied with 1 H micro-Particle Induced X-ray Emission (μPIXE). Concentration profiles of a deuterated molecule in a hair fibre were determined with 3 He micro-Nuclear Reaction Analysis (μNRA). Chlorine and heavy water (D 2 0) diffusion into cement pastes were profiled using a combination of 3 He μPIXE and μNRA. (authors)

Bibliography of geologic studies: Columbia Plateau (Columbia River Basalt) and adjacent areas in Idaho

International Nuclear Information System (INIS)

Strowd, W.

1978-11-01

The objective of this compilation is to present a comprehensive listing of published, unpublished, and open-file references pertaining to the geology of the Columbia Plateau and adjacent areas in the State of Idaho. The bibliography was compiled in support of Rockwell's Basalt Waste Isolation Program that is evaluating the feasibility of nuclear waste storage in the Columbia River Basalt Group. The emphasis is on stratigraphy, structural geology, seismicity, and tectonics, although the nature of Columbia River Basalt distribution in Idaho has necessitated the inclusion of a sizeable collection of references on geology marginal to the Columbia Plateau and associated mineral resources. The bibliography is divided into two major sections, the alphabetical listing of all references and the subject index. The subject index is divided into 19 categories to facilitate locating a specific reference in the user's field of interest

X-ray microbeam stand-alone facility for cultured cells irradiation

Energy Technology Data Exchange (ETDEWEB)

Bożek, Sebastian, E-mail: sebastian.bozek@yahoo.com [Jagiellonian University Medical College, Department of Pharmaceutical Biophysics, Krakow (Poland); Bielecki, Jakub; Wiecheć, Anna; Lekki, Janusz; Stachura, Zbigniew; Pogoda, Katarzyna; Lipiec, Ewelina; Tkocz, Konrad; Kwiatek, Wojciech M. [Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow (Poland)

2017-03-01

Highlights: • An X-ray microbeam line for irradiation of living cultured cells was constructed. • A step by step explanation of working principles with engineering details, procedures and calculations is presented. • A model of beam and cell interaction is presented. • A method of uniform irradiation of living cells with an exact dose per a cell is presented. • Results of preliminary experiments are presented. - Abstract: The article describes an X-ray microbeam standalone facility dedicated for irradiation of living cultured cells. The article can serve as an advice for such facilities construction, as it begins from engineering details, through mathematical modeling and experimental procedures, ending up with preliminary experimental results and conclusions. The presented system consists of an open type X-ray tube with microfocusing down to about 2 μm, an X-ray focusing system with optical elements arranged in the nested Kirckpatrick-Baez (or Montel) geometry, a sample stand and an optical microscope with a scientific digital CCD camera. For the beam visualisation an X-ray sensitive CCD camera and a spectral detector are used, as well as a scintillator screen combined with the microscope. A method of precise one by one irradiation of previously chosen cells is presented, as well as a fast method of uniform irradiation of a chosen sample area. Mathematical models of beam and cell with calculations of kerma and dose are presented. The experiments on dose-effect relationship, kinetics of DNA double strand breaks repair, as well as micronuclei observation were performed on PC-3 (Prostate Cancer) cultured cells. The cells were seeded and irradiated on Mylar foil, which covered a hole drilled in the Petri dish. DNA lesions were visualised with γ-H2AX marker combined with Alexa Fluor 488 fluorescent dye.

Paleodrainage of the Columbia River system on the Columbia Plateau of Washington State: a summary

International Nuclear Information System (INIS)

Fecht, K.R.; Reidel, S.P.; Tallman, A.M.

1985-12-01

The evolution of the Columbia River drainage system on the Columbia Plateau of Washington in the last 17 My reflects the geologic history of the plateau. We have updated an interpretation of the evolution of the Columbia River system and defined the geomorphic and structural features that have controlled the position of ancestral streams. The sequence of geologic events and the resulting drainage system for various time intervals in the last 17 My are summarized below. 121 refs., 14 figs

Emplacement of Columbia River flood basalt

Science.gov (United States)

Reidel, Stephen P.

1998-11-01

Evidence is examined for the emplacement of the Umatilla, Wilbur Creek, and the Asotin Members of Columbia River Basalt Group. These flows erupted in the eastern part of the Columbia Plateau during the waning phases of volcanism. The Umatilla Member consists of two flows in the Lewiston basin area and southwestern Columbia Plateau. These flows mixed to form one flow in the central Columbia Plateau. The composition of the younger flow is preserved in the center and the composition of the older flow is at the top and bottom. There is a complete gradation between the two. Flows of the Wilbur Creek and Asotin Members erupted individually in the eastern Columbia Plateau and also mixed together in the central Columbia Plateau. Comparison of the emplacement patterns to intraflow structures and textures of the flows suggests that very little time elapsed between eruptions. In addition, the amount of crust that formed on the earlier flows prior to mixing also suggests rapid emplacement. Calculations of volumetric flow rates through constrictions in channels suggest emplacement times of weeks to months under fast laminar flow for all three members. A new model for the emplacement of Columbia River Basalt Group flows is proposed that suggests rapid eruption and emplacement for the main part of the flow and slower emplacement along the margins as the of the flow margin expands.

The New York Brain Bank of Columbia University: practical highlights of 35 years of experience.

Science.gov (United States)

Ramirez, Etty Paola Cortes; Keller, Christian Ernst; Vonsattel, Jean Paul

2018-01-01

The New York Brain Bank processes brains and organs of clinically well-characterized patients with age-related neurodegenerative diseases, and for comparison, from individuals without neurologic or psychiatric impairments. The donors, either patients or individuals, were evaluated at healthcare facilities of the Columbia University of New York. Each source brain yields four categories of samples: fresh frozen blocks and crushed parenchyma, and formalin-fixed wet blocks and histology sections. A source brain is thoroughly evaluated to determine qualitatively and quantitatively any changes it might harbor using conventional neuropathologic techniques. The clinical and pathologic diagnoses are integrated to determine the distributive diagnosis assigned to the samples obtained from a source brain. The gradual standardization of the protocol was developed in 1981 in response to the evolving requirements of basic investigations on neurodegeneration. The methods assimilate long-standing experience from multiple centers. The resulting and current protocol includes a constant central core applied to all brains with conditional flexibility around it. The New York Brain Bank is an integral part of the department of pathology, where the expertise, teaching duties, and hardware are shared. Since details of the protocols are available online, this chapter focuses on practical issues in professionalizing brain banking. Copyright © 2018 Elsevier B.V. All rights reserved.

Fabrication of fine imaging devices using an external proton microbeam

Energy Technology Data Exchange (ETDEWEB)

Sakai, T., E-mail: sakai.takuro@jaea.go.jp [Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Yasuda, R.; Iikura, H.; Nojima, T. [Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA), Tokai, Ibaraki 319-1195 (Japan); Koka, M.; Satoh, T.; Ishii, Y. [Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA), Takasaki, Gunma 370-1292 (Japan); Oshima, A. [Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047 (Japan)

2014-08-01

We have successfully fabricated novel microscopic imaging devices made from UV/EB curable resin using an external scanning proton microbeam. The devices are micro-structured fluorescent plates that consist of an array of micro-pillars that align periodically. The base material used in the pillars is UV/EB curable resin and each pillar contains phosphor grains. The pattern exposures were performed using a proton beam writing technique. The height of the pillars depends on the range of the proton beam. Optical microscopy and scanning electron microscopy have been used to characterize the samples. The results show that the fabricated fluorescent plates are expected to be compatible with both spatial resolution and detection efficiency.

Mid-Columbia coho reintroduction feasibility project. Preliminary environmental assessment

International Nuclear Information System (INIS)

1999-01-01

Before the Bonneville Power Administration (BPA) decides whether to fund a program to reintroduce coho salmon to mid-Columbia River basin tributaries, research is needed to determine the ecological risks and biological feasibility of such an effort. Since the early 1900s, the native stock of coho has been decimated in the tributaries of the middle reach of the Columbia River. The four Columbia River Treaty Tribes identified coho reintroduction in the mid-Columbia as a priority in the Tribal Restoration Plan. It is a comprehensive plan put forward by the Tribes to restore the Columbia River fisheries. In 1996, the Northwest Power Planning Council (NPPC) recommended the tribal mid-Columbia reintroduction project for funding by BPA. It was identified as one of fifteen high-priority supplementation projects for the Columbia River basin, and was incorporated into the NPPC's Fish and Wildlife Program. The release of coho from lower Columbia hatcheries into mid-Columbia tributaries is also recognized in the Columbia River Fish Management Plan

Mid-Columbia Coho Salmon Reintroduction Feasibility Project : Environmental Assessment.

Energy Technology Data Exchange (ETDEWEB)

United States. Bonneville Power Administration; Washington (State) Department of Fish and Wildlife; Confederated Tribes and Bands of the Yakama Nation

1999-01-01

Before the Bonneville Power Administration (BPA) decides whether to fund a program to reintroduce coho salmon to mid-Columbia River basin tributaries, research is needed to determine the ecological risks and biological feasibility of such an effort. Since the early 1900s, the native stock of coho has been decimated in the tributaries of the middle reach of the Columbia River. The four Columbia River Treaty Tribes identified coho reintroduction in the mid-Columbia as a priority in the Tribal Restoration Plan. It is a comprehensive plan put forward by the Tribes to restore the Columbia River fisheries. In 1996, the Northwest Power Planning Council (NPPC) recommended the tribal mid-Columbia reintroduction project for funding by BPA. It was identified as one of fifteen high-priority supplementation projects for the Columbia River basin, and was incorporated into the NPPC`s Fish and Wildlife Program. The release of coho from lower Columbia hatcheries into mid-Columbia tributaries is also recognized in the Columbia River Fish Management Plan.

Survey of Columbia River Basin streams for Columbia pebblesnail Fluminicola columbiana and shortface lanx Fisherola nuttalli

International Nuclear Information System (INIS)

Neitzel, D.A.; Frest, T.J.

1992-08-01

At present, there are only two remaining sizable populations of Columbia pebblesnails Fluminicola columbiana; those in the Methow and Okanogan rivers, Washington. Smaller populations survive in the Hanford Reach of the Columbia River, Washington, and the lower Salmon River, Idaho, and possibly in the middle Snake River, Idaho; Hells Canyon of the Snake River, Idaho, Washington, and Oregon, and the Grande Ronde River, Oregon and Washington. Neither large population is at present protected, and there has been a substantial documented reduction in the species' historic range. Large populations of the shortface lanx Fisherolla nuttalli persist in four streams: the Deschutes River, Oregon; the Hanford Reach and Bonneville Dam area of the Columbia River, Washington and Oregon; Hens Canyon of the Snake River, Idaho and Oregon; and the Okanogan River, Washington. Smaller populations, or ones of uncertain size, are known from the lower Salmon and middle Snake rivers, Idaho; the Grande Ronde Washington and Oregon; Imnaha, and John Day rivers, Oregon; and the Methow River, Washington. While substantial range reduction has occurred in this species, and the large populations are not well protected, the problem is not as severe as in the case of the Columbia pebblesnail. Both species appear to have been widespread historically in the mainstem Columbia River and the Columbia River Basin prior to the installation of the current dam system. Both are now apparently reduced within the Columbia River to populations in the Hanford Reach and possibly other sites that are now separated by large areas of unsuitable habitat from those in the river's major tributaries

The STS-93 crew pose in front of Columbia

Science.gov (United States)

1999-01-01

The STS-93 crew pose in front of the Space Shuttle orbiter Columbia following their landing on runway 33 at the Shuttle Landing Facility. Main gear touchdown occurred at 11:20:35 p.m. EDT on July 27. From left to right, they are Mission Specialists Catherine G. Coleman (Ph.D.) and Stephen A. Hawley (Ph.D.), Pilot Jeffrey S. Ashby, Commander Eileen Collins, and Mission Specialist Michel Tognini of France, with the Centre National d'Etudes Spatiales (CNES). The mission's primary objective was to deploy the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. This was the 95th flight in the Space Shuttle program and the 26th for Columbia. The landing was the 19th consecutive Shuttle landing in Florida and the 12th night landing in Shuttle program history. On this mission, Collins became the first woman to serve as a Shuttle commander.

STS-93 Commander Collins poses in front of Columbia

Science.gov (United States)

1999-01-01

STS-93 Commander Eileen Collins poses in front of the Space Shuttle orbiter Columbia following her textbook landing on runway 33 at the Shuttle Landing Facility. Main gear touchdown occurred at 11:20:35 p.m. EDT on July 27. On this mission, Collins became the first woman to serve as a Shuttle commander. Also on board were her fellow STS-93 crew members: Pilot Jeffrey S. Ashby and Mission Specialists Stephen A. Hawley (Ph.D.), Catherine G. Coleman (Ph.D.) and Michel Tognini of France, with the Centre National d'Etudes Spatiales (CNES). The mission's primary objective was to deploy the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. This was the 95th flight in the Space Shuttle program and the 26th for Columbia. The landing was the 19th consecutive Shuttle landing in Florida and the 12th night landing in Shuttle program history.

Hydraulic and sedimentary processes causing anastomosing morphology of the upper Columbia River, British Columbia, Canada

NARCIS (Netherlands)

Makaske, B.; Smith, D.G.; Berendsen, H.J.A.; Boer, de A.G.; Nielen-Kiezebrink, van M.F.; Locking, T.

2009-01-01

The upper Columbia River, British Columbia, Canada, shows typical anastomosing morphology - multiple interconnected channels that enclose floodbasins - and lateral channel stability We analysed field data on hydraulic and sedimentary processes and show that the anastomosing morphology of the upper

Physics study of microbeam radiation therapy with PSI-version of Monte Carlo code GEANT as a new computational tool

CERN Document Server

Stepanek, J; Laissue, J A; Lyubimova, N; Di Michiel, F; Slatkin, D N

2000-01-01

Microbeam radiation therapy (MRT) is a currently experimental method of radiotherapy which is mediated by an array of parallel microbeams of synchrotron-wiggler-generated X-rays. Suitably selected, nominally supralethal doses of X-rays delivered to parallel microslices of tumor-bearing tissues in rats can be either palliative or curative while causing little or no serious damage to contiguous normal tissues. Although the pathogenesis of MRT-mediated tumor regression is not understood, as in all radiotherapy such understanding will be based ultimately on our understanding of the relationships among the following three factors: (1) microdosimetry, (2) damage to normal tissues, and (3) therapeutic efficacy. Although physical microdosimetry is feasible, published information on MRT microdosimetry to date is computational. This report describes Monte Carlo-based computational MRT microdosimetry using photon and/or electron scattering and photoionization cross-section data in the 1 e V through 100 GeV range distrib...

Bystander effect studies using heavy-ion microbeam

International Nuclear Information System (INIS)

Kobayashi, Yasuhiko; Funayama, Tomoo; Sakashita, Tetsuya; Wada, Seiichi; Yokota, Yuichiro; Kakizaki, Takehiko; Hamada, Nobuyuki; Hara, Takamitsu; Fukamoto, Kana; Suzuki, Michiyo; Ni, M.; Furusawa, Yoshiya

2007-01-01

We have established a single cell irradiation system, which allows selected cells to be individually hit with defined number of heavy charged particles, using a collimated heavy-ion microbeam apparatus at JAEA-Takasaki. This system has been developed to study radiobiological processes in hit cells and bystander cells exposed to low dose and low dose-rate high-LET radiations, in ways that cannot be achieved using conventional broad-field exposures. Individual cultured cells grown in special dishes were irradiated in the atmosphere with a single or defined numbers of 18.3 MeV/amu 12 C, 13.0 or 17.5 MeV/amu 20 Ne, and 11.5 MeV/amu 40 Ar ions. Targeting and irradiation of the cells were performed automatically according to the positional data of the target cells microscopically obtained before irradiation. The actual number of particle tracks that pass through target cells was detected with prompt etching of the bottom of the cell dish made of ion track detector TNF-1 (modified CR-39). (author)

3D mapping of individual cells using a proton microbeam

International Nuclear Information System (INIS)

Michelet, C.; Moretto, Ph.

1999-01-01

Various imaging techniques carried out with a nuclear microprobe make it possible to reveal by 2D mapping, the internal structure of isolated cells. An improvement of those techniques allows today 3D mapping of cells. STIM- and PIXE-Tomography have been recently implemented on the CENBG microbeam line. The performance offered by these methods, which are capable of resolving objects having diameters less then 100 μm, has been validated on reference specimens and on human cells from cultures. In addition to the fineness of the resolution, these techniques offer the advantage of performing volume analyses without prior cutting of the samples. The ultimate aim of this program of research is to perform 3D elemental chemical analysis of individual cells in the field of biomedicine

Making microbeams and nanobeams by channeling in microstructures and nanostructures

Directory of Open Access Journals (Sweden)

S. Bellucci

2003-03-01

Full Text Available A particle beam of very small cross section is useful in many accelerator applications including biological and medical ones. We show the capability of the channeling technique using a micron-sized structure on a surface of a single crystal, or using a nanotube, to produce a beam of a cross section down to one square micrometer (or nanometer. The channeled beam can be deflected and thus well separated in angle and space from the primary and scattered particles. Monte Carlo simulation is done to evaluate the characteristics of a channeled microbeam. Emittances down to 0.001 nm rad, and flux up to 10^{6}   μm^{2} per second, can be achieved for protons and ions.

Radiobiological experiments at the Munich ion microbeam SNAKE

Energy Technology Data Exchange (ETDEWEB)

Friedl, A.A.; Drexler, G.A.; Loewe, R. [Strahlenbiologisches Inst., Ludwig-Maximilians-Univ. Muenchen (Germany); Dollinger, G.; Hauptner, A.; Hable, V.; Greubel, C.; Kruecken, R. [Physik Dept. E12, Technische Univ. Muenchen, Garching (Germany); Cremer, T.; Dietzel, S. [Dept. Biologie II, Ludwig-Maximilians-Univ. Muenchen, Planegg-Martinsried (Germany)

2005-07-01

The ion microbeam SNAKE at the Munich 14 MV tandem accelerator was recently adapted for irradiation of cells and is now routinely used for radiobiological experiments. Several features, including ion-optical beam focussing to achieve a targeting accuracy of about 500 nm, fast movement of the beam by electrostatic deflection and single ion preparation make SNAKE an excellent tool for localized irradiation with a defined number of ions. The ion spectrum available ranges from 20 MeV protons to 200 MeV gold ions, thus allowing to vary the LET over four orders of magnitude and to conduct low and high LET irradiation in a single experimental set-up. This offers the possibility of a systematic analysis of the cellular response mechanisms in their dependence on dose and LET. Other current lines of research include analysis of the spatio-temporal dynamics of protein recruitment at damaged chromatin sites and determination of the mobility of damaged chromatin regions in the interphase nucleus. (orig.)

Paintings on copper by the Flemish artist Frans Francken II: PIXE characterization by external microbeam

International Nuclear Information System (INIS)

Corregidor, V.; Oliveira, A.R.; Rodrigues, P.A.; Alves, L.C.

2015-01-01

Resorting to an external proton microbeam, PIXE analyses of three oil paintings on copper support dated from the XVII century and attributed to the Flemish artist Frans Francken II, were undertaken. The present work aims to contribute to the compositional study of the painting materials employed by XVII century artists that exploited copper as a support for oil painting, and specifically the materials used by Francken’s workshop, particularly copper plates. Because of the low thickness of the pictorial layers of this type of paintings and its non-destructive character, PIXE is the ideal technique to study the elemental composition of the paintings. Several spots in each painting were chosen for analysis in order to cover almost all the pigments used in the colour palette. Lead and calcium were detected in practically every analysed regions, probably related to the presence of lead white and chalk, usually used as ground layer on copper paintings. Small quantities of gold were also detected, which is present in many of this artist’s works to embellish some details of the representations. Also this work reports the first application of the external proton microbeam set-up available at CTN/IST in Portugal for the characterization of oil paintings

Branch formation induced by microbeam irradiation of Adiantum protonemata

International Nuclear Information System (INIS)

Wada, M.

1998-01-01

Branches were induced in centrifuged Adiantum protonemal cells by partial irradiation with polarized red light. Nuclear behavior and microtubule pattern change during branch formation were investigated. A branch formed at any part where a red microbeam was focused along a long apical cell. The nucleus moved towards the irradiated area and remained there until a branch developed. The pattern of microtubules changed from parallel to oblique at the irradiated area and then a transverse arrangement of microtubules appeared on both sides of the area. It appeared as if the nucleus was suspended between two microtubule rings. This nuclear behavior and the changes in microtubule pattern were different from those observed during branch formation under whole cell irradiation. From the results of this work we suggest that there is an importance for precise control of experimental conditions

Post-Columbia River Basalt Group stratigraphy and map compilation of the Columbia Plateau, Oregon

International Nuclear Information System (INIS)

Farooqui, S.M.; Bunker, R.C.; Thoms, R.E.; Clayton, D.C.; Bela, J.L.

1981-01-01

This report presents the results of reconnaissance mapping of sedimentary deposits and volcanic rocks overlying the Columbia River Basalt. The project area covers parts of the Dalles, Pendleton, Grangeville, Baker, Canyon City, and Bend. The mapping was done to provide stratigraphic data on the sedimentary deposits and volcanic rocks overlying the Columbia River Basalt Group. 160 refs., 16 figs., 1 tab

Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy.

Science.gov (United States)

Cornelius, Iwan; Guatelli, Susanna; Fournier, Pauline; Crosbie, Jeffrey C; Sanchez Del Rio, Manuel; Bräuer-Krisch, Elke; Rosenfeld, Anatoly; Lerch, Michael

2014-05-01

Microbeam radiation therapy (MRT) is a synchrotron-based radiotherapy modality that uses high-intensity beams of spatially fractionated radiation to treat tumours. The rapid evolution of MRT towards clinical trials demands accurate treatment planning systems (TPS), as well as independent tools for the verification of TPS calculated dose distributions in order to ensure patient safety and treatment efficacy. Monte Carlo computer simulation represents the most accurate method of dose calculation in patient geometries and is best suited for the purpose of TPS verification. A Monte Carlo model of the ID17 biomedical beamline at the European Synchrotron Radiation Facility has been developed, including recent modifications, using the Geant4 Monte Carlo toolkit interfaced with the SHADOW X-ray optics and ray-tracing libraries. The code was benchmarked by simulating dose profiles in water-equivalent phantoms subject to irradiation by broad-beam (without spatial fractionation) and microbeam (with spatial fractionation) fields, and comparing against those calculated with a previous model of the beamline developed using the PENELOPE code. Validation against additional experimental dose profiles in water-equivalent phantoms subject to broad-beam irradiation was also performed. Good agreement between codes was observed, with the exception of out-of-field doses and toward the field edge for larger field sizes. Microbeam results showed good agreement between both codes and experimental results within uncertainties. Results of the experimental validation showed agreement for different beamline configurations. The asymmetry in the out-of-field dose profiles due to polarization effects was also investigated, yielding important information for the treatment planning process in MRT. This work represents an important step in the development of a Monte Carlo-based independent verification tool for treatment planning in MRT.

Role of the micronucleus in stomatogenesis in sexual reproduction of Paramecium tetraurelia: laser microbeam irradiation of the micronucleus

Energy Technology Data Exchange (ETDEWEB)

Tam Laiwa; Ng, S.F.

1986-12-01

Fifteen amicronucleate cell lines and 22 cell lines with defective micronuclei were obtained following selective laser microbeam irradiation of the micronucleus. The amicronucleate cell lines showed reduced growth rate and formed abnormal oral apparatuses in asexual reproduction, and failed to produce any oral apparatus in autogamy. The 22 cell lines with defective micronucleus exhibited various abnormalities of the oral apparatus newly formed during autogamy. These abnormalities included the arrest of membranelle assembly, reduction in the length of the buccal cavity and oral membranelles, disruption of the organization of the membranelles, quadrulation of the dorsal peniculus, and failure of addition of membranellar basal body rows. Hence the micronucleus plays multiple roles in sexual stomatogenesis. Our results agree with the notion that the micronucleus acts during a critical period between the second meiotic division and up to the formation of the zygotic nucleus to control the early stage of oral membranelle assembly. Laser microbeam irradiation might have created recessive mutations and/or chromosomal aberrations, which were expressed during this critical period with the formation of abnormal postmeiotic nuclei.

Vibration analysis of rotating functionally graded Timoshenko microbeam based on modified couple stress theory under different temperature distributions

Science.gov (United States)

Ghadiri, Majid; Shafiei, Navvab

2016-04-01

In this study, thermal vibration of rotary functionally graded Timoshenko microbeam has been analyzed based on modified couple stress theory considering temperature change in four types of temperature distribution on thermal environment. Material properties of FG microbeam are supposed to be temperature dependent and vary continuously along the thickness according to the power-law form. The axial forces are also included in the model as the thermal and true spatial variation due to the rotation. Governing equations and boundary conditions have been derived by employing Hamiltonian's principle. The differential quadrature method is employed to solve the governing equations for cantilever and propped cantilever boundary conditions. Validations are done by comparing available literatures and obtained results which indicate accuracy of applied method. Results represent effects of temperature changes, different boundary conditions, nondimensional angular velocity, length scale parameter, different boundary conditions, FG index and beam thickness on fundamental, second and third nondimensional frequencies. Results determine critical values of temperature changes and other essential parameters which can be applicable to design micromachines like micromotor and microturbine.

Columbia makes a nighttime landing at KSC following STS-93

Science.gov (United States)

1999-01-01

The Space Shuttle orbiter Columbia swoops out of the darkness onto runway 33 at the Shuttle Landing Facility after a successful mission of nearly five days and 1.8 million miles. Main gear touchdown was at 11:20:35 p.m. EDT on July 27. Aboard are the STS-93 crew members: Commander Eileen M. Collins, Pilot Jeffrey S. Ashby, and Mission Specialists Stephen A. Hawley (Ph.D.), Catherine G. Coleman (Ph.D.) and Michel Tognini of France, with the Centre National d'Etudes Spatiales (CNES). The mission's primary objective was to deploy the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. This was the 95th flight in the Space Shuttle program and the 26th for Columbia. The landing was the 19th consecutive Shuttle landing in Florida and the 12th night landing in Shuttle program history.

Avulsions, channel evolution and floodplain sedimentation rates of the anastomosing upper Columbia River, British Columbia, Canada

NARCIS (Netherlands)

Makaske, B.; Smith, D.G.; Berendsen, H.J.A.

2002-01-01

Ages of channels of the anastomosing upper Columbia River, south-eastern British Columbia, Canada, were investigated in a cross-valley transect by C-14 dating of subsurface floodplain organic material from beneath levees. The avulsion history within the transect was deduced from these data, and

Nuclear microbeam study of advanced materials for fusion reactor technology

International Nuclear Information System (INIS)

Alves, L.C.; Alves, E.; Grime, G.W.; Silva, M.F. da; Soares, J.C.

1999-01-01

The Oxford scanning proton microprobe was used to study SiC fibres, SiC/SiC ceramic composites and Be pebbles, which are some of the most important materials for fusion technology. For the SiC materials, although the results reveal a high degree of homogeneity and purity in the composition of the fibres, some grains containing heavy metals were detected in the composites. Rutherford backscattering analysis further allowed establishing that at least some of these grains are not on the surface of the material but rather distributed throughout the bulk of the SiC composites. The two different types of Be pebbles analysed also showed very different levels of contaminants. The information obtained with the microbeam analysis is confronted with the one resulting from the broad beam PIXE and RBS analysis

Water Quality Projects Summary for the Mid-Columbia and Cumberland River Systems

Energy Technology Data Exchange (ETDEWEB)

Stewart, Kevin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hadjerioua, Boualem [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-04-01

Scheduling and operational control of hydropower systems is accompanied with a keen awareness of the management of water use, environmental effects, and policy, especially within the context of strict water rights policy and generation maximization. This is a multi-objective problem for many hydropower systems, including the Cumberland and Mid-Columbia river systems. Though each of these two systems have distinct operational philosophies, hydrologic characteristics, and system dynamics, they both share a responsibility to effectively manage hydropower and the environment, which requires state-of-the art improvements in the approaches and applications for water quality modeling. The Department of Energy and Oak Ridge National Laboratory have developed tools for total dissolved gas (TDG) prediction on the Mid-Columbia River and a decision-support system used for hydropower generation and environmental optimization on the Cumberland River. In conjunction with IIHR - Hydroscience & Engineering, The University of Iowa and University of Colorado s Center for Advanced Decision Support for Water and Environmental Systems (CADSWES), ORNL has managed the development of a TDG predictive methodology at seven dams along the Mid-Columbia River and has enabled the ability to utilize this methodology for optimization of operations at these projects with the commercially available software package Riverware. ORNL has also managed the collaboration with Vanderbilt University and Lipscomb University to develop a state-of-the art method for reducing high-fidelity water quality modeling results into surrogate models which can be used effectively within the context of optimization efforts to maximize generation for a reservoir system based on environmental and policy constraints. The novel contribution of these efforts is the ability to predict water quality conditions with simplified methodologies at the same level of accuracy as more complex and resource intensive computing methods

Columbia River Component Data Evaluation Summary Report

Energy Technology Data Exchange (ETDEWEB)

C.S. Cearlock

2006-08-02

The purpose of the Columbia River Component Data Compilation and Evaluation task was to compile, review, and evaluate existing information for constituents that may have been released to the Columbia River due to Hanford Site operations. Through this effort an extensive compilation of information pertaining to Hanford Site-related contaminants released to the Columbia River has been completed for almost 965 km of the river.

Multi-Scale Action Effectiveness Research in the Lower Columbia River and Estuary, 2011 - FINAL ANNUAL REPORT

Energy Technology Data Exchange (ETDEWEB)

Sather, Nichole K.; Storch, Adam; Johnson, Gary E.; Teel, D. J.; Skalski, J. R.; Bryson, Amanda J.; Kaufmann, Ronald M.; Woodruff, Dana L.; Blaine, Jennifer; Kuligowski, D. R.; Kropp, Roy K.; Dawley, Earl M.

2012-05-31

The study reported here was conducted by researchers at Pacific Northwest National Laboratory (PNNL), the Oregon Department of Fish and Wildlife (ODFW), the University of Washington (UW), and the National Marine Fisheries Service (NMFS) for the U.S. Army Corps of Engineers, Portland District (USACE). This research project was initiated in 2007 by the Bonneville Power Administration to investigate critical uncertainties regarding juvenile salmon ecology in shallow tidal freshwater habitats of the lower Columbia River. However, as part of the Washington Memorandum of Agreement, the project was transferred to the USACE in 2010. In transferring from BPA to the USACE, the focus of the tidal freshwater research project shifted from fundamental ecology toward the effectiveness of restoration in the Lower Columbia River and estuary (LCRE). The research is conducted within the Action Agencies Columbia Estuary Ecosystem Restoration Program (CEERP). Data reported herein spans the time period May 2010 to September 2011.

Synchrotron microbeam radiation therapy induces hypoxia in intracerebral gliosarcoma but not in the normal brain

International Nuclear Information System (INIS)

Bouchet, Audrey; Lemasson, Benjamin; Christen, Thomas; Potez, Marine; Rome, Claire; Coquery, Nicolas; Le Clec’h, Céline; Moisan, Anaick; Bräuer-Krisch, Elke; Leduc, Géraldine; Rémy, Chantal; Laissue, Jean A.; Barbier, Emmanuel L.; Brun, Emmanuel; Serduc, Raphaël

2013-01-01

Purpose: Synchrotron microbeam radiation therapy (MRT) is an innovative irradiation modality based on spatial fractionation of a high-dose X-ray beam into lattices of microbeams. The increase in lifespan of brain tumor-bearing rats is associated with vascular damage but the physiological consequences of MRT on blood vessels have not been described. In this manuscript, we evaluate the oxygenation changes induced by MRT in an intracerebral 9L gliosarcoma model. Methods: Tissue responses to MRT (two orthogonal arrays (2 × 400 Gy)) were studied using magnetic resonance-based measurements of local blood oxygen saturation (MR S O 2 ) and quantitative immunohistology of RECA-1, Type-IV collagen and GLUT-1, marker of hypoxia. Results: In tumors, MR S O 2 decreased by a factor of 2 in tumor between day 8 and day 45 after MRT. This correlated with tumor vascular remodeling, i.e. decrease in vessel density, increases in half-vessel distances (×5) and GLUT-1 immunoreactivity. Conversely, MRT did not change normal brain MR S O 2 , although vessel inter-distances increased slightly. Conclusion: We provide new evidence for the differential effect of MRT on tumor vasculature, an effect that leads to tumor hypoxia. As hypothesized formerly, the vasculature of the normal brain exposed to MRT remains sufficiently perfused to prevent any hypoxia

The Origin of the Columbia Hills

Science.gov (United States)

Rice, J. W.

2005-12-01

The Columbia Hills form a rugged ridge complex comprised of 7 peaks spanning some 3.5 km in length and reaching a maximum height of 106 m (Husband Hill) above the plains of Spirit's landing site. As of this writing Spirit has been exploring the Columbia Hills for over 440 sols (since sol 156 on June 11, 2004). Thus far the origin of the Columbia Hills has remained elusive despite detailed analysis of numerous rock and soil targets, including outcrops. The chemical differences among the 6 distinct rock classes attest to the lithologic diversity and geologic complexity of the Hills. Origin of the Columbia Hills Several hypothesis have been put forth to explain the origin of the Columbia Hills: Old eroded partially buried impact crater rim(s), central peak, residual intracrater fill material, volcanic construct, wrinkle ridge, delta and or combinations of the above. Observations that support various aspects of these multiple hypotheses will be discussed. Numerous buried craters are observed on the floor of Gusev lending credence to the idea that the Columbia Hills are the remains of an ancient impact crater rim or possibly a central peak. Morphologic evidence of the rim of Thira crater and the Columbia Hills appears to support this hypothesis. The Aeolis region contains numerous craters that contain layered materials in the absence of any major fluvial systems. This could imply that the Columbia Hills are the remnants of a formerly extensive unit(s). Gusev contains many hills scattered across its floor such as Grissom, White, Chaffee and numerous other buttes and mesas that may be remnants of a former extensive intracrater deposit. Another possibility is that the Columbia Hills are composed of volcanic materials (cinder cones and associated ash and lava flows) derived either locally or from Apollinaris Patera located 300 km to the north. Several depressions are located in the Columbia Hills. These features could be calderas but are most likely impact craters. The most

Monte Carlo-based treatment planning system calculation engine for microbeam radiation therapy.

Science.gov (United States)

Martinez-Rovira, I; Sempau, J; Prezado, Y

2012-05-01

Microbeam radiation therapy (MRT) is a synchrotron radiotherapy technique that explores the limits of the dose-volume effect. Preclinical studies have shown that MRT irradiations (arrays of 25-75-μm-wide microbeams spaced by 200-400 μm) are able to eradicate highly aggressive animal tumor models while healthy tissue is preserved. These promising results have provided the basis for the forthcoming clinical trials at the ID17 Biomedical Beamline of the European Synchrotron Radiation Facility (ESRF). The first step includes irradiation of pets (cats and dogs) as a milestone before treatment of human patients. Within this context, accurate dose calculations are required. The distinct features of both beam generation and irradiation geometry in MRT with respect to conventional techniques require the development of a specific MRT treatment planning system (TPS). In particular, a Monte Carlo (MC)-based calculation engine for the MRT TPS has been developed in this work. Experimental verification in heterogeneous phantoms and optimization of the computation time have also been performed. The penelope/penEasy MC code was used to compute dose distributions from a realistic beam source model. Experimental verification was carried out by means of radiochromic films placed within heterogeneous slab-phantoms. Once validation was completed, dose computations in a virtual model of a patient, reconstructed from computed tomography (CT) images, were performed. To this end, decoupling of the CT image voxel grid (a few cubic millimeter volume) to the dose bin grid, which has micrometer dimensions in the transversal direction of the microbeams, was performed. Optimization of the simulation parameters, the use of variance-reduction (VR) techniques, and other methods, such as the parallelization of the simulations, were applied in order to speed up the dose computation. Good agreement between MC simulations and experimental results was achieved, even at the interfaces between two

Monte Carlo-based treatment planning system calculation engine for microbeam radiation therapy

Energy Technology Data Exchange (ETDEWEB)

Martinez-Rovira, I.; Sempau, J.; Prezado, Y. [Institut de Tecniques Energetiques, Universitat Politecnica de Catalunya, Diagonal 647, Barcelona E-08028 (Spain) and ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 rue Jules Horowitz B.P. 220, F-38043 Grenoble Cedex (France); Institut de Tecniques Energetiques, Universitat Politecnica de Catalunya, Diagonal 647, Barcelona E-08028 (Spain); Laboratoire Imagerie et modelisation en neurobiologie et cancerologie, UMR8165, Centre National de la Recherche Scientifique (CNRS), Universites Paris 7 et Paris 11, Bat 440., 15 rue Georges Clemenceau, F-91406 Orsay Cedex (France)

2012-05-15

Purpose: Microbeam radiation therapy (MRT) is a synchrotron radiotherapy technique that explores the limits of the dose-volume effect. Preclinical studies have shown that MRT irradiations (arrays of 25-75-{mu}m-wide microbeams spaced by 200-400 {mu}m) are able to eradicate highly aggressive animal tumor models while healthy tissue is preserved. These promising results have provided the basis for the forthcoming clinical trials at the ID17 Biomedical Beamline of the European Synchrotron Radiation Facility (ESRF). The first step includes irradiation of pets (cats and dogs) as a milestone before treatment of human patients. Within this context, accurate dose calculations are required. The distinct features of both beam generation and irradiation geometry in MRT with respect to conventional techniques require the development of a specific MRT treatment planning system (TPS). In particular, a Monte Carlo (MC)-based calculation engine for the MRT TPS has been developed in this work. Experimental verification in heterogeneous phantoms and optimization of the computation time have also been performed. Methods: The penelope/penEasy MC code was used to compute dose distributions from a realistic beam source model. Experimental verification was carried out by means of radiochromic films placed within heterogeneous slab-phantoms. Once validation was completed, dose computations in a virtual model of a patient, reconstructed from computed tomography (CT) images, were performed. To this end, decoupling of the CT image voxel grid (a few cubic millimeter volume) to the dose bin grid, which has micrometer dimensions in the transversal direction of the microbeams, was performed. Optimization of the simulation parameters, the use of variance-reduction (VR) techniques, and other methods, such as the parallelization of the simulations, were applied in order to speed up the dose computation. Results: Good agreement between MC simulations and experimental results was achieved, even at

Microbeam line of MeV heavy ions for materials modification and in-situ analysis

International Nuclear Information System (INIS)

Horino, Yuji; Chayahara, Akiyoshi; Kiuchi, Masato; Fujii, Kanenaga; Satoh, Mamoru; Takai, Mikio.

1990-01-01

A microbeam line for MeV heavy ions of almost any element has been developed for microion-beam processing such as maskless MeV ion implantation and its in-situ analysis. Beam spot sizes of 4.0 μm x 4.0 μm for 3 MeV C 2+ and 9.6 μm x 4.8 μm for 1.8 MeV Au 2+ beams were obtained. Maskless MeV gold ion implantation to a silicon substrate and in-situ microanalysis before and after ion implantation were demonstrated. (author)

Nucleolus degradation and growth induced by uv-microbeam irradiation of interphase cells grown in culture

International Nuclear Information System (INIS)

Sakharov, V.N.; Voronkova, N.

1976-01-01

In contrast to total cell irradiation, local UV-microbeam irradiation can stimulate a significant diminution in the irradiated mature nucleoli in interphase mammalian cells in culture. This diminution is accompanied by the concomitant expansion of the unirradiated nucleoli within the same nucleus, and the total nucleolar volume per nucleus does not change appreciably. It is suggested that these nucleolar volume changes are the result of the dispersion, migration, and redistribution of the nucleolar material between competitive nucleolar organizer regions of the interphase nucleus

FIREBall-2: Trailblazing observations of the space UV circumgalactic medium (Columbia University, Co-I Proposal)

Science.gov (United States)

Schiminovich, David

Columbia University is a Co-I institution in a collaborative research program with Caltech, the Lead Institution (PI: Christopher Martin). The Faint Intergalactic-medium Redshifted Emission Balloon (FIREBall-2) is designed to discover and map faint emission from the circumgalactic medium of low redshift galaxies (0.3zz 0.7, conduct a targeted search of circumquasar (CQM) media for selected targets, and conduct follow up on likely tar-gets selected via GALEX and a pilot survey conducted by our group. We will also conduct a statistical search for the faint IGM via statistical stacking of our data. The FIREBall-2 team includes two female graduate students in key roles (both of whom are finishing their PhDs in 2016) and is overseen by a female Postdoctoral scholar (supported by NSF AAPF and Caltech Millikan Fellowships, in addition to a recent Roman Technology Fellowship award). Additional funding is necessary to keep this highly qualified balloon team together for a second flight. FIREBall-2 will test key technologies and science strategies for a future space mission to map emission from CGM and IGM baryons. Its flights will continue to provide important training for the next generation of space astrophysicists working in UV and other wavelength instrumentation. Most importantly, FIREBall-2 will detect emission from the CGM of nearby galaxies, providing the first census of the density and kinematics of this material for low z galaxies and open-ing a new field of CGM science.

The role of the micronucleus in stomatogenesis in sexual reproduction of Paramecium tetraurelia: laser microbeam irradiation of the micronucleus

International Nuclear Information System (INIS)

Tam Laiwa; Ng, S.F.

1986-01-01

Fifteen amicronucleate cell lines and 22 cell lines with defective micronuclei were obtained following selective laser microbeam irradiation of the micronucleus. The amicronucleate cell lines showed reduced growth rate and formed abnormal oral apparatuses in asexual reproduction, and failed to produce any oral apparatus in autogamy. The 22 cell lines with defective micronucleus exhibited various abnormalities of the oral apparatus newly formed during autogamy. These abnormalities included the arrest of membranelle assembly, reduction in the length of the buccal cavity and oral membranelles, disruption of the organization of the membranelles, quadrulation of the dorsal peniculus, and failure of addition of membranellar basal body rows. Hence the micronucleus plays multiple roles in sexual stomatogenesis. Our results agree with the notion that the micronucleus acts during a critical period between the second meiotic division and up to the formation of the zygotic nucleus to control the early stage of oral membranelle assembly. Laser microbeam irradiation might have created recessive mutations and/or chromosomal aberrations, which were expressed during this critical period with the formation of abnormal postmeiotic nuclei. (author)

Applications of high-throughput clonogenic survival assays in high-LET particle microbeams

Directory of Open Access Journals (Sweden)

Antonios eGeorgantzoglou

2016-01-01

Full Text Available Charged particle therapy is increasingly becoming a valuable tool in cancer treatment, mainly due to the favorable interaction of particle radiation with matter. Its application is still limited due, in part, to lack of data regarding the radiosensitivity of certain cell lines to this radiation type, especially to high-LET particles. From the earliest days of radiation biology, the clonogenic survival assay has been used to provide radiation response data. This method produces reliable data but it is not optimized for high-throughput microbeam studies with high-LET radiation where high levels of cell killing lead to a very low probability of maintaining cells’ clonogenic potential. A new method, therefore, is proposed in this paper, which could potentially allow these experiments to be conducted in a high-throughput fashion. Cells are seeded in special polypropylene dishes and bright-field illumination provides cell visualization. Digital images are obtained and cell detection is applied based on corner detection, generating individual cell targets as x-y points. These points in the dish are then irradiated individually by a micron field size high-LET microbeam. Post-irradiation, time-lapse imaging follows cells’ response. All irradiated cells are tracked by linking trajectories in all time-frames, based on finding their nearest position. Cell divisions are detected based on cell appearance and individual cell temporary corner density. The number of divisions anticipated is low due to the high probability of cell killing from high-LET irradiation. Survival curves are produced based on cell’s capacity to divide at least 4-5 times. The process is repeated for a range of doses of radiation. Validation shows the efficiency of the proposed cell detection and tracking method in finding cell divisions.

Applications of High-Throughput Clonogenic Survival Assays in High-LET Particle Microbeams.

Science.gov (United States)

Georgantzoglou, Antonios; Merchant, Michael J; Jeynes, Jonathan C G; Mayhead, Natalie; Punia, Natasha; Butler, Rachel E; Jena, Rajesh

2015-01-01

Charged particle therapy is increasingly becoming a valuable tool in cancer treatment, mainly due to the favorable interaction of particle radiation with matter. Its application is still limited due, in part, to lack of data regarding the radiosensitivity of certain cell lines to this radiation type, especially to high-linear energy transfer (LET) particles. From the earliest days of radiation biology, the clonogenic survival assay has been used to provide radiation response data. This method produces reliable data but it is not optimized for high-throughput microbeam studies with high-LET radiation where high levels of cell killing lead to a very low probability of maintaining cells' clonogenic potential. A new method, therefore, is proposed in this paper, which could potentially allow these experiments to be conducted in a high-throughput fashion. Cells are seeded in special polypropylene dishes and bright-field illumination provides cell visualization. Digital images are obtained and cell detection is applied based on corner detection, generating individual cell targets as x-y points. These points in the dish are then irradiated individually by a micron field size high-LET microbeam. Post-irradiation, time-lapse imaging follows cells' response. All irradiated cells are tracked by linking trajectories in all time-frames, based on finding their nearest position. Cell divisions are detected based on cell appearance and individual cell temporary corner density. The number of divisions anticipated is low due to the high probability of cell killing from high-LET irradiation. Survival curves are produced based on cell's capacity to divide at least four to five times. The process is repeated for a range of doses of radiation. Validation shows the efficiency of the proposed cell detection and tracking method in finding cell divisions.

Sounding narrative medicine: studying students' professional identity development at Columbia University College of Physicians and Surgeons.

Science.gov (United States)

Miller, Eliza; Balmer, Dorene; Hermann, Nellie; Graham, Gillian; Charon, Rita

2014-02-01

To learn what medical students derive from training in humanities, social sciences, and the arts in a narrative medicine curriculum and to explore narrative medicine's framework as it relates to students' professional development. On completion of required intensive, half-semester narrative medicine seminars in 2010, 130 second-year medical students at Columbia University College of Physicians and Surgeons participated in focus group discussions of their experiences. Focus group transcriptions were submitted to close iterative reading by a team who performed a grounded-theory-guided content analysis, generating a list of codes into which statements were sorted to develop overarching themes. Provisional interpretations emerged from the close and repeated readings, suggesting a fresh conceptual understanding of how and through what avenues such education achieves its goals in clinical training. Students' comments articulated the known features of narrative medicine--attention, representation, and affiliation--and endorsed all three as being valuable to professional identity development. They spoke of the salience of their work in narrative medicine to medicine and medical education and its dividends of critical thinking, reflection, and pleasure. Critiques constituted a small percentage of the statements in each category. Students report that narrative medicine seminars support complex interior, interpersonal, perceptual, and expressive capacities. Students' lived experiences confirm some expectations of narrative medicine curricular planners while exposing fresh effects of such work to view.

Sounding Narrative Medicine: Studying Students’ Professional Identity Development at Columbia University College of Physicians and Surgeons

Science.gov (United States)

Miller, Eliza; Balmer, Dorene; Hermann, Nellie; Graham, Gillian; Charon, Rita

2014-01-01

Purpose To learn what medical students derive from training in humanities, social sciences, and the arts in a narrative medicine curriculum and to explore narrative medicine’s framework as it relates to students’ professional development. Method On completion of required intensive, half-semester narrative medicine seminars in 2010, 130 second-year medical students at Columbia University College of Physicians and Surgeons participated in focus group discussions of their experiences. Focus group transcriptions were submitted to close iterative reading by a team who performed a grounded-theory-guided content analysis, generating a list of codes into which statements were sorted to develop overarching themes. Provisional interpretations emerged from the close and repeated readings, suggesting a fresh conceptual understanding of how and through what avenues such education achieves its goals in clinical training. Results Students’ comments articulated the known features of narrative medicine—attention, representation, and affiliation—and endorsed all three as being valuable to professional identity development. They spoke of the salience of their work in narrative medicine to medicine and medical education and its dividends of critical thinking, reflection, and pleasure. Critiques constituted a small percentage of the statements in each category. Conclusions Students report that narrative medicine seminars support complex interior, interpersonal, perceptual, and expressive capacities. Students’ lived experiences confirm some expectations of narrative medicine curricular planners while exposing fresh effects of such work to view. PMID:24362390

Columbia River Pathway Dosimetry Report, 1944-1992

International Nuclear Information System (INIS)

Farris, W.T.; Napier, B.A.; Simpson, J.C.; Snyder, S.F.; Shipler, D.B.

1994-04-01

The purpose of the Hanford Environmental Dose Reconstruction (HEDR) Project is to estimate the radiation dose that individuals could have received as a result of radionuclide emissions since 1944 from the Hanford Site. One objective of the HEDR Project is to estimate doses to individuals who were exposed to the radionuclides released to the Columbia River (the river pathway). This report documents the last in a series of dose calculations conducted on the Columbia River pathway. The report summarizes the technical approach used to estimate radiation doses to three classes of representative individuals who may have used the Columbia River as a source of drinking water, food, or for recreational or occupational purposes. In addition, the report briefly explains the approaches used to estimate the radioactivity released to the river, the development of the parameters used to model the uptake and movement of radioactive materials in aquatic systems such as the Columbia River, and the method of calculating the Columbia River's transport of radioactive materials. Potential Columbia River doses have been determined for representative individuals since the initiation of site activities in 1944. For this report, dose calculations were performed using conceptual models and computer codes developed for the purpose of estimating doses. All doses were estimated for representative individuals who share similar characteristics with segments of the general population

Columbia Estuary Ecosystem Restoration Program. 2012 Synthesis Memorandum

Science.gov (United States)

2013-01-01

LCFRB Lower Columbia Fish Recovery Board LCRE lower Columbia River and estuary LCREP Lower Columbia River Estuary Partnership LWD large woody debris...hydraulic reconnections, channel creation, large woody debris [ LWD ] placement) have restored a total of 3152 acres since 2001. If land acquisition...fencing, invasive plant removal, native replanting. Mirror Lake 208 Culvert replaced with a bridge, riparian restoration, LWD enhancement, culvert

Operational Performance of the Two-Channel 10 Megawatt Feedback Amplifier System for MHD Control on the Columbia University HBT-EP Tokamak

International Nuclear Information System (INIS)

Reass, W.A.; Wurden, G.A.

1997-01-01

The operational characteristics and performance of the two channel 10 Megawatt MHD feedback control system as installed by Los Alamos National Laboratory on the Columbia University HBT-EP tokamak are described. In the present configuration, driving independent 300 microH saddle coil sets, each channel can deliver 1100 Amperes and 16 kV peak to peak. Full power bandwidth is about 12 kHz, with capabilities at reduced power to 30 kHz. The present system topology is designed to suppress magnetohydrodynamic activity with m=2, n=1 symmetry. Application of either static (single phase) or rotating (twin phased) magnetic perturbations shows the ability to spin up or slow down the plasma, and also prevent (or cause) so-called ''mode-locking''. Open loop and active feedback experiments using a digital signal processor (DSP) have been performed on the HBT-EP tokamak and initial results show the ability to manipulate the plasma MHD mode frequency

Big and Little Feet Provincial Profiles: British Columbia

Directory of Open Access Journals (Sweden)

Sarah Dobson

2017-09-01

Full Text Available This communiqué provides a summary of the production- and consumption-based greenhouse gas emissions accounts for British Columbia, as well as their associated trade flows. It is part of a series of communiqués profiling the Canadian provinces and territories.1 In simplest terms, a production-based emissions account measures the quantity of greenhouse gas emissions produced in British Columbia. In contrast, a consumptionbased emissions account measures the quantity of greenhouse gas emissions generated during the production process for final goods and services that are consumed in British Columbia through household purchases, investment by firms and government spending. Trade flows refer to the movement of emissions that are produced in British Columbia but which support consumption in a different province, territory or country (and vice versa. For example, emissions at the Port of Vancouver that are associated with goods that are subsequently exported to Ontario for sale are recorded as a trade flow from British Columbia to Ontario. Moving in the opposite direction, emissions associated with the production of Alberta crude oil that is refined in British Columbia and sold as motor gasoline to a British Columbia consumer are recorded as a trade flow from Alberta to British Columbia. For further details on these results in a national context, the methodology for generating them and their policy implications, please see the companion papers to this communiqué series: (1 Fellows and Dobson (2017; and (2 Dobson and Fellows (2017. Additionally, the consumption emissions and trade flow data for each of the provinces and territories are available at: http://www.policyschool.ca/embodied-emissions-inputs-outputs-datatables-2004-2011/.

"Universities, the Major Battleground in the Fight for Reason and Capitalism"

Science.gov (United States)

Jones, Gary H.

2010-01-01

At the turn of the twentieth century, the presidents of Harvard University, Columbia University, and the University of Chicago issued declarations bolstering institutional resistance to attempts by external agencies to influence a faculty member's stance on issues of the day. The American Association of University Professors (AAUP) emerged some…

Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray microbeam.

Science.gov (United States)

Graceffa, Rita; Nobrega, R Paul; Barrea, Raul A; Kathuria, Sagar V; Chakravarthy, Srinivas; Bilsel, Osman; Irving, Thomas C

2013-11-01

Small-angle X-ray scattering (SAXS) is a well established technique to probe the nanoscale structure and interactions in soft matter. It allows one to study the structure of native particles in near physiological environments and to analyze structural changes in response to variations in external conditions. The combination of microfluidics and SAXS provides a powerful tool to investigate dynamic processes on a molecular level with sub-millisecond time resolution. Reaction kinetics in the sub-millisecond time range has been achieved using continuous-flow mixers manufactured using micromachining techniques. The time resolution of these devices has previously been limited, in part, by the X-ray beam sizes delivered by typical SAXS beamlines. These limitations can be overcome using optics to focus X-rays to the micrometer size range providing that beam divergence and photon flux suitable for performing SAXS experiments can be maintained. Such micro-SAXS in combination with microfluidic devices would be an attractive probe for time-resolved studies. Here, the development of a high-duty-cycle scanning microsecond-time-resolution SAXS capability, built around the Kirkpatrick-Baez mirror-based microbeam system at the Biophysics Collaborative Access Team (BioCAT) beamline 18ID at the Advanced Photon Source, Argonne National Laboratory, is reported. A detailed description of the microbeam small-angle-scattering instrument, the turbulent flow mixer, as well as the data acquisition and control and analysis software is provided. Results are presented where this apparatus was used to study the folding of cytochrome c. Future prospects for this technique are discussed.

Analysis of metallic pigments by ion microbeam

International Nuclear Information System (INIS)

Pelicon, P.; Klanjsek-Gunde, M.; Kunaver, M.; Simcic, J.; Budnar, M.

2002-01-01

Metallic paints consist of metallic flakes dispersed in a resinous binder, i.e. a light-element polymer matrix. The spatial distribution and orientation of metallic flakes inside the matrix determines the covering efficiency of the paint, glossiness, and its angular-dependent properties such as lightness flop or color flop (two-tone). Such coatings are extensively used for a functional (i.e. security) as well as decorative purpose. The ion microbeam analysis of two types of silver paint with imbedded metallic flakes has been performed to determine the spatial distribution of the aluminum flakes in paint layer. The average sizes of the aluminum flakes were 23 μm (size distribution 10-37) and 49 μm (size distribution 34-75), respectively. The proton beam with the size of 2x2 μm 2 at Ljubljana ion microprobe has been used to scan the surface of the pigments. PIXE mapping of Al Kα map shows lateral distribution of the aluminum flakes, whereas the RBS slicing method reveals tomograms of the flakes in uppermost 7 μm of the pigment layer. The series of point analysis aligned over the single flake reveal the flake angle in respect to the polymer matrix surface. The angular sensitivity is well below 1 angular degree

A method of dosimetry for synchrotron microbeam radiation therapy using radiochromic films and microdensitometry

International Nuclear Information System (INIS)

Crosbie, J. C.; Svalbe, I. D.; Lewis, R. A.

2007-01-01

Full text: Normal tissue displays an exceptional tolerance to high doses of radiation (hundreds of Gy) when delivered as a microplanar array of synchrotron-generated x-rays. Furthermore, MRT has been shown to cause significant tumour growth delay and in some case complete ablation. The biological effects of MRT on tissue are not fully understood. This is further complicated by difficulties in performing accurate dosimetry. The majority of dosimetry performed for MRT has been Monte Carlo simulations. The aim of this work was to utilise film dosimetry and microdensitometry to measure the peak-to-valley dose ratios (PVDRs) for synchrotron microbeam radiation therapy.

Columbia River water quality monitoring

International Nuclear Information System (INIS)

Anon.

1983-01-01

Waste water from Hanford activities is discharged at eight points along the Hanford reach of the Columbia River. These discharges consist of backwash water from water intake screens, cooling water, river bank springs, water storage tank overflow, and fish laboratory waste water. Each discharge point is identified in an existing National Pollutant Discharge Elimination System (NPDES) permit issued by the EPA. Effluents from each of these outfalls are routinely monitored and reported by the operating contractors as required by their NPDES permits. Measurements of several Columbia River water quality parameters were conducted routinely during 1982 both upstream and downstream of the Hanford Site to monitor any effects on the river that may be attributable to Hanford discharges and to determine compliance with the Class A designation requirements. The measurements indicated that Hanford operations had a minimal, if any, impact on the quality of the Columbia River water

Micro-CT of sea urchin ossicles supplemented with microbeam diffraction

Science.gov (United States)

Stock, Stuart R.; Ignatiev, Konstantin I.; Veis, Arthur; De Carlo, Francesco; Almer, J. D.

2004-10-01

Sea urchins employ as wide a range of composite reinforcement strategies as are seen in engineering composites. Besides tailoring reinforcement morphology and alignment to the functional demands of position, solid solution strengthening (high Mg calcite), inclusion toughening (macromolecules), functional gradients in mineral reinforcement morphology, composition and dimensions and mineral interface tailoring are other tactics important to achieving high toughness and high strength in sea urchin teeth. Teeth from different echinoid families illustrate combinations of reinforcement parameters and toughening mechanisms providing good functionality, a virtual probe of the available design space. This paper focuses on a multi-mode x-ray investigation of sea urchin teeth studied on scales approaching 1 μm in millimeter-sized samples, in particular mapping 3-D microarchitecture with synchrotron and laboratory microCT and mapping Ca1-xMgxCO3 crystal composition x and microstrain and crystallite size via microbeam diffraction.

Annotated bibliography of the geology of the Columbia Plateau (Columbia River Basalt) and adjacent areas of Oregon

International Nuclear Information System (INIS)

Bela, J.

1979-01-01

This bibliography containing approximately 2000 entries was prepared by the Oregon Department of Geology and Mineral Industries under Subcontract SA-913 with Rockwell Hanford Operations' Basalt Waste Isolation Program. The objective of the Basalt Waste Isolation Program is to determine the feasibility of storing nuclear waste within the Columbia River Basalt Group. Under the geologic portion of this program, the stratigraphic, structural, tectonic, seismic, and hydrologic aspects of the Columbia Plateau are being examined. Other aspects of the Basalt Waste Isolation Program are concerned with systems integration, engineered barriers, engineering testing, and construction of a near-surface test facility. The area covered in this bibliography comprises that area north of 43 0 30' latitude and east of the Willamette Meridian, which is located just west of Portland. The bibliographic entries are presented in two forms. The first is an alphabetized listing of all articles dealing with the geology of the Columbia Plateau (Columbia River Basalt) and adjacent areas of Oregon. The second form consists of an alphabetized listing of the entries subdivided under fourteen categories

Annotated bibliography of the geology of the Columbia Plateau (Columbia River Basalt) and adjacent areas of Oregon

Energy Technology Data Exchange (ETDEWEB)

Bela, J.

1979-01-01

This bibliography containing approximately 2000 entries was prepared by the Oregon Department of Geology and Mineral Industries under Subcontract SA-913 with Rockwell Hanford Operations' Basalt Waste Isolation Program. The objective of the Basalt Waste Isolation Program is to determine the feasibility of storing nuclear waste within the Columbia River Basalt Group. Under the geologic portion of this program, the stratigraphic, structural, tectonic, seismic, and hydrologic aspects of the Columbia Plateau are being examined. Other aspects of the Basalt Waste Isolation Program are concerned with systems integration, engineered barriers, engineering testing, and construction of a near-surface test facility. The area covered in this bibliography comprises that area north of 43/sup 0/30' latitude and east of the Willamette Meridian, which is located just west of Portland. The bibliographic entries are presented in two forms. The first is an alphabetized listing of all articles dealing with the geology of the Columbia Plateau (Columbia River Basalt) and adjacent areas of Oregon. The second form consists of an alphabetized listing of the entries subdivided under fourteen categories. (RWR)

Microbeam facility extension for single-cell irradiation experiments. Investigations about bystander effect and reactive oxygen species impact

International Nuclear Information System (INIS)

Hanot, M.; Khodja, H.; Daudin, L.; Hoarau, J.; Carriere, M.; Gouget, B.

2006-01-01

The LPS microbeam facility is based on a KN3750 Van de Graaff accelerator devoted to microbeam analysis [1]. It is equipped with two horizontal microbeam lines used in various fields such as material science, geological science, nuclear material science and biology. Since two years, a single ion hit device is being developed at the LPS. The setup is dedicated to the study of ionizing radiation effects on living cells by performing single ion irradiation at controlled doses and locations. This study will complete current researches conducted on uranium chemical toxicity on renal an d osteoblastic cells. After ingestion, most uranium is excreted from the body within a few days except small fraction that is absorbed into the blood-stream (0.2 to 5%) and then deposit and preferentially in kidneys and bones, where it can remain for many years. Uranium is a heavy metal and a primarily alpha emitter. It can lead to bone cancer as a result of the ionizing radiation associated with the radioactive decay products. The study of the response to an exposure to alpha particles will permit to distinguish radiotoxicity and chemical toxicity of uranium bone cells with a special emphasis or the bystander effect at low dose.All the beam lines at the LPS nuclear microprobe are horizontal and under vacuum. A dedicated deflecting magnet was inserted in one of the two available beam lines of the facility. The ion beam is extracted to air using a 100 nm thick silicon nitride membrane, thin enough to induce negligible effects on the ions in terms of energy loss and spatial resolution. By this way, we believe that we minimize the experimental setup impact on the living cells easing the detection of low irradiation dose impact. The atmosphere around the samples is also important to guaranty low stressed cell culture conditions. A temperature, hygrometry and CO 2 controlled atmosphere device will be implanted in the future. The irradiation microbeam is produced using a fused silica capillary

British Columbia : an alternative design

International Nuclear Information System (INIS)

Ostergaard, P.

2003-01-01

This PowerPoint presentation outlined the British Columbia Ministry of Energy and Mines' approach to the electricity market. A brief overview of the electric system in the province was provided, examining capacity (primarily hydro based) and the utility sector with its public ownership. In British Columbia, 80 per cent of the electricity is generated by British Columbia Hydro (BC Hydro). The rates are based on cost of service. British Columbia's market is western North America. A comparison of monthly bills for several large cities, both Canadian and American, was displayed. The market reviews conducted in 1995, 1998, and 2002 were reviewed and the major recommendations discussed. The author identified the opportunities in the province, discussing natural gas and coal for electricity production, resource potential, demand, and private sector capacity. The challenges facing the province are: cost effective development of resources to meet energy demand; aging infrastructure, high reliability requirements and economic growth; evolving electricity market structure in the United States; and, monopoly. The transmission system was reviewed with reference to trade with the Pacific Northwest, flexibility and storage. The energy plan objectives for the future were presented, including low rates and public ownership, secure and reliable supply, more private sector opportunities, and environmental responsibility. The alternative market structure includes regulated market characteristics, access to trade, and customer focus. figs

77 FR 69511 - Columbia ETF Trust, et al.; Notice of Application

Science.gov (United States)

2012-11-19

...] Columbia ETF Trust, et al.; Notice of Application November 13, 2012. AGENCY: Securities and Exchange...'') (each, an ``Adviser'', together, the ``Advisers'') and Columbia ETF Trust, Columbia ETF Trust I... Fund, Inc. and Tri-Continental Corporation are closed-end registered investment companies. Columbia ETF...

Evaluation of Life History Diversity, Habitat Connectivity, and Survival Benefits Associated with Habitat Restoration Actions in the Lower Columbia River and Estuary, Annual Report 2009

Energy Technology Data Exchange (ETDEWEB)

Diefenderfer, Heida L.; Johnson, Gary E.; Sather, Nichole K.; Skalski, John R.; Dawley, Earl M.; Coleman, Andre M.

2010-08-01

This report describes the 2009 research conducted under the U.S. Army Corps of Engineers (USACE or Corps) project EST-09-P-01, titled “Evaluation of Life History Diversity, Habitat Connectivity, and Survival Benefits Associated with Habitat Restoration Actions in the Lower Columbia River and Estuary.” The research was conducted by the Pacific Northwest National Laboratory, Marine Science Laboratory and Hydrology Group, in partnership with the University of Washington, School of Aquatic and Fishery Sciences, Columbia Basin Research, and Earl Dawley (NOAA Fisheries, retired). This Columbia River Fish Mitigation Program project, referred to as “Salmonid Benefits,” was started in FY 2009 to evaluate the state-of-the science regarding the ability to quantify the benefits to listed salmonids1 of habitat restoration actions in the lower Columbia River and estuary.

High-precision radiosurgical dose delivery by interlaced microbeam arrays of high-flux low-energy synchrotron X-rays.

Directory of Open Access Journals (Sweden)

Raphaël Serduc

Full Text Available Microbeam Radiation Therapy (MRT is a preclinical form of radiosurgery dedicated to brain tumor treatment. It uses micrometer-wide synchrotron-generated X-ray beams on the basis of spatial beam fractionation. Due to the radioresistance of normal brain vasculature to MRT, a continuous blood supply can be maintained which would in part explain the surprising tolerance of normal tissues to very high radiation doses (hundreds of Gy. Based on this well described normal tissue sparing effect of microplanar beams, we developed a new irradiation geometry which allows the delivery of a high uniform dose deposition at a given brain target whereas surrounding normal tissues are irradiated by well tolerated parallel microbeams only. Normal rat brains were exposed to 4 focally interlaced arrays of 10 microplanar beams (52 microm wide, spaced 200 microm on-center, 50 to 350 keV in energy range, targeted from 4 different ports, with a peak entrance dose of 200Gy each, to deliver an homogenous dose to a target volume of 7 mm(3 in the caudate nucleus. Magnetic resonance imaging follow-up of rats showed a highly localized increase in blood vessel permeability, starting 1 week after irradiation. Contrast agent diffusion was confined to the target volume and was still observed 1 month after irradiation, along with histopathological changes, including damaged blood vessels. No changes in vessel permeability were detected in the normal brain tissue surrounding the target. The interlacing radiation-induced reduction of spontaneous seizures of epileptic rats illustrated the potential pre-clinical applications of this new irradiation geometry. Finally, Monte Carlo simulations performed on a human-sized head phantom suggested that synchrotron photons can be used for human radiosurgical applications. Our data show that interlaced microbeam irradiation allows a high homogeneous dose deposition in a brain target and leads to a confined tissue necrosis while sparing

Ion and electron Van de Graaff accelerators of Kyoto University

International Nuclear Information System (INIS)

Fukuzawa, F.; Imanishi, N.; Tomita, M.; Norisawa, K.; Yoshida, K.; Ohdaira, T.

1990-01-01

Two Van de Graaff accelerators are available at the Uji campus of Kyoto University. One is a 4MV machine, which is used for heavy ion acceleration, while the other is a 2MV machine for electron acceleration. These machines have been modified in various parts and currently used very actively in many fields of investigation. Important modifications of the 4MV machine are: use of a newly developed accelerating tube, addition of a charge-changer before the analyzing magnet, renewal of the charging belt, and development of a microbeam system for PIXE and RBS analysis. An attempt is now being made to accelerate micro-particles using the 2MV machine. The new accelerating tube has bucket type electrodes with large accelerating apertures. By charge-changing the accelerated 1+ ions to higher charge states, 2+, 3+, ..., at the entrance of the analyzing magnet, Ar ions with energies of up to 2.73, 6.21, .... MeV can be deflected to the duct. Scanning microbeam PIXE and RBS are powerful tools for analysis of spatial elemental distribution. Calculations suggest that a beam size of about 3 μm can be attained by using an object aperture of 10μm in diameter and controlling the beam divergence within 10μ rad in both directions. (N.K.)

Monte Carlo study of the influence of energy spectra, mesh size, high Z element on dose and PVDR based on 1-D and 3-D heterogeneous mouse head phantom for Microbeam Radiation Therapy.

Science.gov (United States)

Lin, Hui; Jing, Jia; Xu, Liangfeng; Mao, Xiaoli

2017-12-01

To evaluate the influence of energy spectra, mesh sizes, high Z element on dose and PVDR in Microbeam Radiation Therapy (MRT) based on 1-D analogy-mouse-head-model (1-D MHM) and 3-D voxel-mouse-head-phantom (3-D VMHP) by Monte Carlo simulation. A Microbeam-Array-Source-Model was implemented into EGSnrc/DOSXYZnrc. The microbeam size is assumed to be 25μm, 50μm or 75μm in thickness and fixed 1mm in height with 200μmc-t-c. The influence of the energy spectra of ID17@ESRF and BMIT@CLS were investigated. The mesh size was optimized. PVDR in 1-D MHM and 3-D VMHP was compared with the homogeneous water phantom. The arc influence of 3-D VMHP filled with water (3-D VMHWP) was compared with the rectangle phantom. PVDR of the lower BMIT@CLS spectrum is 2.4times that of ID17@ESRF for lower valley dose. The optimized mesh is 5µm for 25µm, and 10µm for 50µm and 75µm microbeams with 200µmc-t-c. A 500μm skull layer could make PVDR difference up to 62.5% for 1-D MHM. However this influence is limited (influence is limited for the more depth (influence of 3-D heterogeneous media. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Complete synchronization condition in a network of piezoelectric micro-beam

International Nuclear Information System (INIS)

Taffoti Yolong, V.Y.; Woafo, P.

2007-10-01

This work deals with the dynamics of a network of piezoelectric micro-beams. The complete synchronization condition for this class of chaotic nonlinear electromechanical systems devices with nearest-neighbor diffusive coupling is studied. The nonlinearities on the device studied here are both on the electrical component and on the mechanical one. The investigation is made for the case of a large number of discrete piezoelectric disks coupled. The problem of chaos synchronization is described and converted into the analysis of stability of the system via its differential equations. We show that the complete synchronization of N identical coupled nonlinear chaotic systems having the shift invariant coupling schemes can be calculated from the synchronization of two of them coupled in both directions. According to analytical, semi-analytical predictions and numerical calculations, the transition boundaries for chaos synchronization state in the coupled system are determined as a function of the increasing number of oscillators. (author)

Piezoelectric transduction of flexural modes in pre-stressed microbeam resonators

Science.gov (United States)

Torri, G. B.; Janssen, N. M. A.; Zeng, Z.; Rottenberg, X.; Karabacak, D. M.; Vandecasteele, M.; Van Hoof, C.; Puers, R.; Tilmans, H. A. C.

2014-08-01

This paper reports on the optimization of the design of piezoelectric transducer elements integrated on doubly-clamped microbeam resonators utilized as (bio)chemical sensors. We report and emphasize the often forgotten influence of membrane stresses on defining the dimensions and optimal position of the piezoelectric transducer elements. The study takes into account stress induced structural changes and provides models for the equivalent motional parameters of resonators with particular shapes of the transducers matching the flexural modes of vibration. The above is analyzed theoretically using numerical models and is confirmed by impedance measurements and optical measurements of fabricated doubly-clamped beam resonators. We propose various transducer designs and highlight the advantages of using higher order vibration modes by implementing specially designed mode matching transducer elements. It is concluded that the paper describes and highlights the importance of accounting for the membrane stresses to optimize the resonator performance and the low power in electronic feedback of resonating sensing systems.

Piezoelectric transduction of flexural modes in pre-stressed microbeam resonators

International Nuclear Information System (INIS)

Torri, G B; Rottenberg, X; Hoof, C Van; Puers, R; Tilmans, H A C; Janssen, N M A; Zeng, Z; Karabacak, D M; Vandecasteele, M

2014-01-01

This paper reports on the optimization of the design of piezoelectric transducer elements integrated on doubly-clamped microbeam resonators utilized as (bio)chemical sensors. We report and emphasize the often forgotten influence of membrane stresses on defining the dimensions and optimal position of the piezoelectric transducer elements. The study takes into account stress induced structural changes and provides models for the equivalent motional parameters of resonators with particular shapes of the transducers matching the flexural modes of vibration. The above is analyzed theoretically using numerical models and is confirmed by impedance measurements and optical measurements of fabricated doubly-clamped beam resonators. We propose various transducer designs and highlight the advantages of using higher order vibration modes by implementing specially designed mode matching transducer elements. It is concluded that the paper describes and highlights the importance of accounting for the membrane stresses to optimize the resonator performance and the low power in electronic feedback of resonating sensing systems. (paper)

Are the Columbia River Basalts, Columbia Plateau, Idaho, Oregon, and Washington, USA, a viable geothermal target? A preliminary analysis

Science.gov (United States)

Burns, Erick R.; Williams, Colin F.; Tolan, Terry; Kaven, Joern Ole

2016-01-01

The successful development of a geothermal electric power generation facility relies on (1) the identification of sufficiently high temperatures at an economically viable depth and (2) the existence of or potential to create and maintain a permeable zone (permeability >10-14 m2) of sufficient size to allow efficient long-term extraction of heat from the reservoir host rock. If both occur at depth under the Columbia Plateau, development of geothermal resources there has the potential to expand both the magnitude and spatial extent of geothermal energy production. However, a number of scientific and technical issues must be resolved in order to evaluate the likelihood that the Columbia River Basalts, or deeper geologic units under the Columbia Plateau, are viable geothermal targets.Recent research has demonstrated that heat flow beneath the Columbia Plateau Regional Aquifer System may be higher than previously measured in relatively shallow (characteristic of natural hydrothermal reservoirs. From a hydraulic perspective, Columbia River Basalts are typically divided into dense, impermeable flow interiors and interflow zones comprising the top of one flow, the bottom of the overlying flow, and any sedimentary interbed. Interflow zones are highly variable in texture but, at depths 10-14 m2) interflows are documented at depths up to ~1,400 m. If the elevated permeability in these zones persists to greater depths, they may provide natural permeability of sufficient magnitude to allow their exploitation as conventional geothermal reservoirs. Alternatively, if the permeability in these interflow zones is less than 10-14 m2 at depth, it may be possible to use hydraulic and thermal stimulation to enhance the permeability of both the interflow zones and the natural jointing within the low-permeability interior portions of individual basalt flows in order to develop Enhanced/Engineered Geothermal System (EGS) reservoirs. The key challenge for an improved Columbia Plateau

The CHPRC Columbia River Protection Project Quality Assurance Project Plan

International Nuclear Information System (INIS)

Fix, N.J.

2008-01-01

Pacific Northwest National Laboratory researchers are working on the CHPRC Columbia River Protection Project (hereafter referred to as the Columbia River Project). This is a follow-on project, funded by CH2M Hill Plateau Remediation Company, LLC (CHPRC), to the Fluor Hanford, Inc. Columbia River Protection Project. The work scope consists of a number of CHPRC funded, related projects that are managed under a master project (project number 55109). All contract releases associated with the Fluor Hanford Columbia River Project (Fluor Hanford, Inc. Contract 27647) and the CHPRC Columbia River Project (Contract 36402) will be collected under this master project. Each project within the master project is authorized by a CHPRC contract release that contains the project-specific statement of work. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by the Columbia River Project staff

The CHPRC Columbia River Protection Project Quality Assurance Project Plan

Energy Technology Data Exchange (ETDEWEB)

Fix, N. J.

2008-11-30

Pacific Northwest National Laboratory researchers are working on the CHPRC Columbia River Protection Project (hereafter referred to as the Columbia River Project). This is a follow-on project, funded by CH2M Hill Plateau Remediation Company, LLC (CHPRC), to the Fluor Hanford, Inc. Columbia River Protection Project. The work scope consists of a number of CHPRC funded, related projects that are managed under a master project (project number 55109). All contract releases associated with the Fluor Hanford Columbia River Project (Fluor Hanford, Inc. Contract 27647) and the CHPRC Columbia River Project (Contract 36402) will be collected under this master project. Each project within the master project is authorized by a CHPRC contract release that contains the project-specific statement of work. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by the Columbia River Project staff.

40 CFR 81.108 - Columbia Intrastate Air Quality Control Region.

Science.gov (United States)

2010-07-01

... Quality Control Regions § 81.108 Columbia Intrastate Air Quality Control Region. The Columbia Intrastate Air Quality Control Region (South Carolina) consists of the territorial area encompassed by the... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Columbia Intrastate Air Quality...

Nitric oxide-mediated bystander signal transduction induced by heavy-ion microbeam irradiation

Science.gov (United States)

Tomita, Masanori; Matsumoto, Hideki; Funayama, Tomoo; Yokota, Yuichiro; Otsuka, Kensuke; Maeda, Munetoshi; Kobayashi, Yasuhiko

2015-07-01

In general, a radiation-induced bystander response is known to be a cellular response induced in non-irradiated cells after receiving bystander signaling factors released from directly irradiated cells within a cell population. Bystander responses induced by high-linear energy transfer (LET) heavy ions at low fluence are an important health problem for astronauts in space. Bystander responses are mediated via physical cell-cell contact, such as gap-junction intercellular communication (GJIC) and/or diffusive factors released into the medium in cell culture conditions. Nitric oxide (NO) is a well-known major initiator/mediator of intercellular signaling within culture medium during bystander responses. In this study, we investigated the NO-mediated bystander signal transduction induced by high-LET argon (Ar)-ion microbeam irradiation of normal human fibroblasts. Foci formation by DNA double-strand break repair proteins was induced in non-irradiated cells, which were co-cultured with those irradiated by high-LET Ar-ion microbeams in the same culture plate. Foci formation was suppressed significantly by pretreatment with an NO scavenger. Furthermore, NO-mediated reproductive cell death was also induced in bystander cells. Phosphorylation of NF-κB and Akt were induced during NO-mediated bystander signaling in the irradiated and bystander cells. However, the activation of these proteins depended on the incubation time after irradiation. The accumulation of cyclooxygenase-2 (COX-2), a downstream target of NO and NF-κB, was observed in the bystander cells 6 h after irradiation but not in the directly irradiated cells. Our findings suggest that Akt- and NF-κB-dependent signaling pathways involving COX-2 play important roles in NO-mediated high-LET heavy-ion-induced bystander responses. In addition, COX-2 may be used as a molecular marker of high-LET heavy-ion-induced bystander cells to distinguish them from directly irradiated cells, although this may depend on the time

Microscopic residual stress evolution during deformation process of an Fe---Mn---Si---Cr shape memory alloy investigated using white X-ray microbeam diffraction

International Nuclear Information System (INIS)

Kwon, E.P.; Sato, S.; Fujieda, S.; Shinoda, K.; Kajiwara, K.; Sato, M.; Suzuki, S.

2013-01-01

Microscopic residual stress evolution in different austenite (γ) grains during shape memory process in an Fe---Mn---Si---Cr alloy was investigated using the white X-ray microbeam diffraction technique. The use of high-energy white X-ray microbeam with small beam size allowed us to measure the microscopic residual stress in coarse γ grains with specific orientation. After tensile deformation large compressive residual stress was evolved in γ grains due to the formation of stress-induced ε martensite, but upon recovery heating it almost disappeared as a result of reverse transformation of martensite. The magnitude of compressive residual stress was higher in grains with orientations close to 〈144〉 and 〈233〉 orientations than in a grain with near 〈001〉 orientation. Analysis of the microstructure of each grain using electron backscattering diffraction suggested that the difference in the magnitude of compressive residual stress could be attributed to different martensitic transformation characteristics in the grains

Real-time observation of irradiated Hela-cell Modified by Fluorescent ubiquitination-based Cell Cycle Indicator Using Synchrotron X-Ray Microbeam

International Nuclear Information System (INIS)

Narita, A.; Noguchi, M.; Kaminaga, K.; Yokoya, A.; Kobayashi, K.; Usami, N.; Fujii, K.

2015-01-01

Fluorescent ubiquitination-based cell-cycle indicator (FUCCI) human cancer (HeLa) cells (red indicates G1; green, S/G2) were exposed to a synchrotron X-ray microbeam. Cells in either G1 or S/G2 were irradiated selectively according to their colour in the same microscopic field. Time-lapse micrographs of the irradiated cells were acquired for 24 h after irradiation. For fluorescent immunostaining, phosphorylated histone proteins (γ-H2AX) indicated the induction of DNA double-strand breaks. The cell cycle was arrested by irradiation at S/G2. In contrast, cells irradiated at G1 progressed to S/G2. The foci were induced in cells irradiated at both G1 and S/G2, suggesting that the G1-S (or S) checkpoint pathway does not function in HeLa cells due to the fact that the cells are functionally p53 deficient, even though X-ray microbeam irradiation significantly induces double-strand breaks. These results demonstrate that single FUCCI cell exposure and live cell imaging are powerful methods for studying the effects of radiation on the cell cycle. (authors)

White Sturgeon Mitigation and Restoration in the Columbia and Snake Rivers Upstream from Bonneville Dam; Annual Progress Report, April 2007 - March 2008.

Energy Technology Data Exchange (ETDEWEB)

Mallette, Christine [Oregon Department of Fish and Wildlife

2009-07-28

We report on our progress from April 2007 through March 2008 on determining the effects of mitigative measures on productivity of white sturgeon populations in the Columbia River downstream from McNary Dam, and on determining the status and habitat requirements of white sturgeon populations in the Columbia and Snake rivers upstream from McNary Dam. The study is a cooperative effort by the Oregon Department of Fish and Wildlife (ODFW; Report A), Washington Department of Fish and Wildlife (WDFW; Report B), Columbia River Inter-Tribal Fish Commission (CRITFC; Report C), and Montana State University (MSU; Report D). This is a multi-year study with many objectives requiring more than one year to complete; therefore, findings from a given year may be part of more significant findings yet to be reported.

PIXE microbeam analysis of the metallic debris release around endosseous implants

International Nuclear Information System (INIS)

Buso, G.P.; Galassini, S.; Moschini, G.; Passi, P.; Zadro, A.; Uzunov, N.M.; Doyle, B.L.; Rossi, P.; Provencio, P.

2005-01-01

The mechanical friction that occurs during the surgical insertion of endosseous implants, both in dentistry and orthopaedics, may cause the detachment of metal debris which are dislodged into the peri-implant tissues and can lead to adverse clinical effects. This phenomenon more likely happens with coated or roughened implants that are the most widely employed. In the present study were studied dental implants screws made of commercially pure titanium and coated using titanium plasma-spray (TPS) technique. The implants were inserted in the tibia of rabbits, and removed 'en bloc' with the surrounding bone after one month. After proper processing and mounting on plastic holders, samples from bones were analysed by EDXRF setup at of National Laboratories of Legnaro, INFN, Italy, and consequently at 3 MeV proton microbeam setup at Sandia National Laboratories. Elemental maps were drawn, showing some occasional presence of metal particles in the peri-implant bone

Multi-Scale Action Effectiveness Research in the Lower Columbia River and Estuary, 2012

Energy Technology Data Exchange (ETDEWEB)

Johnson, Gary E.; Sather, Nichole K.; Storch, Adam; Johnson, Jeff; Skalski, J. R.; Teel, D. J.; Brewer, Taylor; Bryson, Amanda J.; Dawley, Earl M.; Kuligowski, D. R.; Whitesel, T.; Mallette, Christine

2013-11-30

The study reported herein was conducted for the U.S. Army Corps of Engineers, Portland District (USACE) by researchers at the Pacific Northwest National Laboratory (PNNL), Oregon Department of Fish and Wildlife (ODFW), National Marine Fisheries Service (NMFS), University of Washington (UW), and U.S. Fish and Wildlife Service (USFWS). The goal of the study was to evaluate the ecological benefits of restoration actions for juvenile salmon in the lower Columbia River and estuary (LCRE; rkm 0–234).

Ultrastructural changes in nucleoli and fibrillar centers under the effect of local ultraviolet microbeam irradiation of interphase culture cells

International Nuclear Information System (INIS)

Zatsepina, O.V.; Voronkova, L.N.; Sakharov, V.N.; Chentsov, Y.S.

1989-01-01

As shown previously, ultraviolet (uv) microbeam irradiation of one of the two mature nucleoli within an interphase cell nucleus causes significant diminution and inactivation of the irradiated nucleolus and compensatory growth and activation of the nonirradiated one. In the present work we describe the results of an ultrastructural study of this phenomenon. The changes in the nucleoli were examined by means of complete series of ultrathin sections obtained from seven irradiated pig kidney cells. The compensatory hypertrophy of the nonirradiated nucleoli is shown to be accompanied by a nearly twofold increase in the number of fibrillar centers (FCs) and by a decrease in their linear dimensions compared with the control cells of the same ploidy. In the degraded nucleoli the number of FCs decreases, but their dimensions increase. Ultraviolet microbeam irradiation causes dramatic diminution of the dense fibrillar component within the irradiated nucleoli as well. The nucleolar capacity for compensatory hypertrophy indicates that in addition to active ribosomal genes, mature nucleoli also contain silent genes capable of being activated under extreme conditions to sustain the required level of rRNA synthesis. It is assumed that activation of latent ribosomal genes is accompanied by FC fragmentation without a considerable increase in their total volume per cell

White Sturgeon Mitigation and Restoration in the Columbia and Snake Rivers Upstream from Bonneville Dam; 2000-2001 Annual Report.

Energy Technology Data Exchange (ETDEWEB)

Kern, J. Chris; Ward, David L.; Farr, Ruth A. (Oregon Department of Fish and Wildlife)

2002-02-01

We report on our progress from April 2000 through March 2001 on determining the effects of mitigative measures on productivity of white sturgeon populations in the Columbia River downstream from McNary Dam, and on determining the status and habitat requirements of white sturgeon populations in the Columbia and Snake rivers upstream from McNary Dam. The study is a cooperative effort by the Oregon Department of Fish and Wildlife (ODFW; Report A), Washington Department of Fish and Wildlife (WDFW; Report B), U.S. Geological Survey Biological Resources Division (USGS; Report C), Columbia River Inter-Tribal Fish Commission (CRITFC; Report D), the U.S. Fish and Wildlife Service (USFWS; Report E), and Oregon State University (OSU; Report F). This is a multi-year study with many objectives requiring more than one year to complete; therefore, findings from a given year may be part of more significant findings yet to be reported. Highlights of results of our work from April 2000 through March 2001 are listed.

White Sturgeon Mitigation and Restoration in the Columbia and Snake Rivers Upstream from Bonneville Dam; 1998-1999 Annual Report.

Energy Technology Data Exchange (ETDEWEB)

Ward, David L.

2000-12-01

The authors report on their progress from April 1998 through March 1999 on determining the effects of mitigative measures on productivity of white sturgeon populations in the Columbia River downstream from McNary Dam, and on determining the status and habitat requirements of white sturgeon populations in the Columbia and Snake rivers upstream from McNary Dam. The study is a cooperative effort by the Oregon Department of Fish and Wildlife (ODFW; Report A), Washington Department of Fish and Wildlife (WDFW; Report B), U.S. Geological Survey Biological Resources Division (USGS; Report C), U.S. Fish and Wildlife Service (USFWS; Report D), Columbia River Inter-Tribal Fish Commission (CRITFC; Report E), and the University of Idaho (UI; Report F). This is a multi-year study with many objectives requiring more than one year to complete. Therefore, findings from a given year may be part of more significant findings yet to be reported. Highlights of results of our work from April 1998 through March 1999 are given.

Columbia Public Health Core Curriculum: Short-Term Impact.

Science.gov (United States)

Begg, Melissa D; Fried, Linda P; Glover, Jim W; Delva, Marlyn; Wiggin, Maggie; Hooper, Leah; Saxena, Roheeni; de Pinho, Helen; Slomin, Emily; Walker, Julia R; Galea, Sandro

2015-12-01

We evaluated a transformed core curriculum for the Columbia University, Mailman School of Public Health (New York, New York) master of public health (MPH) degree. The curriculum, launched in 2012, aims to teach public health as it is practiced: in interdisciplinary teams, drawing on expertise from multiple domains to address complex health challenges. We collected evaluation data starting when the first class of students entered the program and ending with their graduation in May 2014. Students reported being very satisfied with and challenged by the rigorous curriculum and felt prepared to integrate concepts across varied domains and disciplines to solve public health problems. This novel interdisciplinary program could serve as a prototype for other schools that wish to reinvigorate MPH training.

Practice and payment preferences of newly practising family physicians in British Columbia

Science.gov (United States)

Brcic, Vanessa; McGregor, Margaret J.; Kaczorowski, Janusz; Dharamsi, Shafik; Verma, Serena

2012-01-01

Abstract Objective To examine the remuneration model preferences of newly practising family physicians. Design Mixed-methods study comprising a cross-sectional, Web-based survey, as well as qualitative content analysis of answers to open-ended questions. Setting British Columbia. Participants University of British Columbia family practice residents who graduated between 2000 and 2009. Main outcome measures Preferred remuneration models of newly practising physicians. Results The survey response rate was 31% (133 of 430). Of respondents, 71% (93 of 132) preferred non–fee-for-service practice models and 86% (110 of 132) identified the payment model as very or somewhat important in their choice of future practice. Three principal themes were identified from content analysis of respondents’ open-ended comments: frustrations with fee-for-service billing, which encompassed issues related to aggravations with “the business side of things” and was seen as impeding “the freedom to focus on medicine”; quality of patient care, which embraced the importance of a payment model that supported “comprehensive patient care” and “quality rather than quantity”; and freedom to choose, which supported the plurality of practice preferences among providers who strived to provide quality care for patients, “whatever model you happen to be working in.” Conclusion Newly practising physicians in British Columbia preferred alternatives to fee-for-service payment models, which were perceived as contributing to fewer frustrations with billing systems, improved quality of work life, and better quality of patient care. PMID:22586205

77 FR 24146 - Drawbridge Operation Regulation; Columbia River, Vancouver, WA

Science.gov (United States)

2012-04-23

... schedule that governs the Burlington Northern Santa Fe (BNSF) Railway Bridge across the Columbia River... span of the BNSF Railway Bridge across the Columbia River will be disabled and the bridge will not be... allows the swing span of the BNSF Railway Bridge across the Columbia River, mile 105.6, to remain in the...

Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray microbeam

International Nuclear Information System (INIS)

Graceffa, Rita; Nobrega, R. Paul; Barrea, Raul A.; Kathuria, Sagar V.; Chakravarthy, Srinivas; Bilsel, Osman; Irving, Thomas C.

2013-01-01

The development of a high-duty-cycle microsecond time-resolution SAXS capability at the Biophysics Collaborative Access Team beamline (BioCAT) 18ID at the Advanced Photon Source, Argonne National Laboratory, USA, is reported. Small-angle X-ray scattering (SAXS) is a well established technique to probe the nanoscale structure and interactions in soft matter. It allows one to study the structure of native particles in near physiological environments and to analyze structural changes in response to variations in external conditions. The combination of microfluidics and SAXS provides a powerful tool to investigate dynamic processes on a molecular level with sub-millisecond time resolution. Reaction kinetics in the sub-millisecond time range has been achieved using continuous-flow mixers manufactured using micromachining techniques. The time resolution of these devices has previously been limited, in part, by the X-ray beam sizes delivered by typical SAXS beamlines. These limitations can be overcome using optics to focus X-rays to the micrometer size range providing that beam divergence and photon flux suitable for performing SAXS experiments can be maintained. Such micro-SAXS in combination with microfluidic devices would be an attractive probe for time-resolved studies. Here, the development of a high-duty-cycle scanning microsecond-time-resolution SAXS capability, built around the Kirkpatrick–Baez mirror-based microbeam system at the Biophysics Collaborative Access Team (BioCAT) beamline 18ID at the Advanced Photon Source, Argonne National Laboratory, is reported. A detailed description of the microbeam small-angle-scattering instrument, the turbulent flow mixer, as well as the data acquisition and control and analysis software is provided. Results are presented where this apparatus was used to study the folding of cytochrome c. Future prospects for this technique are discussed

Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray microbeam

Energy Technology Data Exchange (ETDEWEB)

Graceffa, Rita, E-mail: rita.graceffa@gmail.com [Illinois Institute of Technology, 3101 South Dearborn, Chicago, IL 60616 (United States); Nobrega, R. Paul [University of Massachusetts Medical School, 364 Plantation Street, LRB 919, Worcester, MA 01605 (United States); Barrea, Raul A. [Illinois Institute of Technology, 3101 South Dearborn, Chicago, IL 60616 (United States); Kathuria, Sagar V. [University of Massachusetts Medical School, 364 Plantation Street, LRB 919, Worcester, MA 01605 (United States); Chakravarthy, Srinivas [Illinois Institute of Technology, 3101 South Dearborn, Chicago, IL 60616 (United States); Bilsel, Osman [University of Massachusetts Medical School, 364 Plantation Street, LRB 919, Worcester, MA 01605 (United States); Irving, Thomas C. [Illinois Institute of Technology, 3101 South Dearborn, Chicago, IL 60616 (United States)

2013-11-01

The development of a high-duty-cycle microsecond time-resolution SAXS capability at the Biophysics Collaborative Access Team beamline (BioCAT) 18ID at the Advanced Photon Source, Argonne National Laboratory, USA, is reported. Small-angle X-ray scattering (SAXS) is a well established technique to probe the nanoscale structure and interactions in soft matter. It allows one to study the structure of native particles in near physiological environments and to analyze structural changes in response to variations in external conditions. The combination of microfluidics and SAXS provides a powerful tool to investigate dynamic processes on a molecular level with sub-millisecond time resolution. Reaction kinetics in the sub-millisecond time range has been achieved using continuous-flow mixers manufactured using micromachining techniques. The time resolution of these devices has previously been limited, in part, by the X-ray beam sizes delivered by typical SAXS beamlines. These limitations can be overcome using optics to focus X-rays to the micrometer size range providing that beam divergence and photon flux suitable for performing SAXS experiments can be maintained. Such micro-SAXS in combination with microfluidic devices would be an attractive probe for time-resolved studies. Here, the development of a high-duty-cycle scanning microsecond-time-resolution SAXS capability, built around the Kirkpatrick–Baez mirror-based microbeam system at the Biophysics Collaborative Access Team (BioCAT) beamline 18ID at the Advanced Photon Source, Argonne National Laboratory, is reported. A detailed description of the microbeam small-angle-scattering instrument, the turbulent flow mixer, as well as the data acquisition and control and analysis software is provided. Results are presented where this apparatus was used to study the folding of cytochrome c. Future prospects for this technique are discussed.

Columbia River Component Data Gap Analysis

Energy Technology Data Exchange (ETDEWEB)

L. C. Hulstrom

2007-10-23

This Data Gap Analysis report documents the results of a study conducted by Washington Closure Hanford (WCH) to compile and reivew the currently available surface water and sediment data for the Columbia River near and downstream of the Hanford Site. This Data Gap Analysis study was conducted to review the adequacy of the existing surface water and sediment data set from the Columbia River, with specific reference to the use of the data in future site characterization and screening level risk assessments.

A study with microbeam PIXE technique needed for the interpretation of data on pollutants in hair obtained with NAA and other bulk concentration analysis. Part of a coordinated programme on nuclear-based methods for analysis of pollutants in human hair

International Nuclear Information System (INIS)

Houtman, J.P.W.

1981-01-01

Hair metals the analysis of which has been proposed as a practical method for assaying human contamination with metal pollutants, reflect both internal and external contamination. This study is an attempt to distinguish these two components of hair metals, using the scanning microbeam PIXE technique. Individual hair strands were embedded in a resin combined with a hardener. Each embedded hair strand was cut perpendicular to its axis, into the root, 1-cm and 2-cm segments from the root. The 3 segments were analysed for few elements including As and Pb, using the scanning microbeam PIXE technique. For each segment, a proton microbeam of 15μ diameter and 500Hz frequency was used to scan the segment cross-section along the long axis. X-ray spectrometry was used to determine the concentrations of the elements studied. The results, although preliminary, showed that the scanning microbeam PIXE technique may provide important information about elemental concentrations and distribution patterns along hair length and hair cross-section. This may lead to a better understanding of mechanisms responsible for the deposition of elements into hair and thereby to a more rational use of hair analysis as a method for assaying human exposure to element pollutants

Graphitized silicon carbide microbeams: wafer-level, self-aligned graphene on silicon wafers

International Nuclear Information System (INIS)

Cunning, Benjamin V; Ahmed, Mohsin; Mishra, Neeraj; Kermany, Atieh Ranjbar; Iacopi, Francesca; Wood, Barry

2014-01-01

Currently proven methods that are used to obtain devices with high-quality graphene on silicon wafers involve the transfer of graphene flakes from a growth substrate, resulting in fundamental limitations for large-scale device fabrication. Moreover, the complex three-dimensional structures of interest for microelectromechanical and nanoelectromechanical systems are hardly compatible with such transfer processes. Here, we introduce a methodology for obtaining thousands of microbeams, made of graphitized silicon carbide on silicon, through a site-selective and wafer-scale approach. A Ni-Cu alloy catalyst mediates a self-aligned graphitization on prepatterned SiC microstructures at a temperature that is compatible with silicon technologies. The graphene nanocoating leads to a dramatically enhanced electrical conductivity, which elevates this approach to an ideal method for the replacement of conductive metal films in silicon carbide-based MEMS and NEMS devices. (paper)

Genotoxic damage in non-irradiated cells: contribution from the bystander effect

International Nuclear Information System (INIS)

Zhou, H.; Randers-Pherson, G.; Suzuki, M.; Waldren, C.A.; Hei, T.K.

2002-01-01

It has always been accepted dogma that the deleterious effects of ionising radiation such as mutagenesis and carcinogenesis are due mainly to direct damage to DNA. Using the Columbia University charged-particle microbeam and the highly sensitive A L cell mutagenic assay, it is shown here that non-irradiated cells acquire the mutagenic phenotype through direct contact with cells whose nuclei are traversed with 2 alpha particles each. Pre-treatment of cells with lindane, a gap junction inhibitor, significantly decreased the mutant yield. Furthermore, when irradiated cells were mixed with control cells in a similar ration as the in situ studies, no enhancement in bystander mutagenesis was detected. Our studies provide clear evidence that genotoxic damage can be induced in non-irradiated cells, and that gap junction mediated cell-cell communication plays a critical role in the bystander phenomenon. (author)

Cognitive Dissidents Bite the Dust--The Demise of University Education in Canada's Prisons.

Science.gov (United States)

Duguid, Stephen

1993-01-01

Documents the demise of the 20-year university education program in British Columbia prisons as a new national strategy stressed correctional goals and behavior change over the humanities/moral development thrust of the Simon Fraser University curriculum. (SK)

Synchrotron X-ray micro-beam studies of ancient Egyptian make-up

International Nuclear Information System (INIS)

Martinetto, P.; Anne, M.; Dooryhee, E.; Drakopoulos, M.; Dubus, M.; Salomon, J.; Simionovici, A.; Walter, Ph.

2001-01-01

Vases full of make-up are most often present in the burial furniture of Egyptian tombs dated from the pharaonic period. The powdered cosmetics made of isolated grains are analysed to identify their trace element signature. From this signature we identify the provenance of the mineral ingredients in the make-up and we observe different impurities in products, which have been demonstrated as synthetic substances by previous works. Focused X-ray micro-beam (2x5 μm 2 ) is successively tuned at 11 keV, below the L III absorption edge of Pb, and 31.8 keV for global characterisation of the metal impurities. The fluorescence signal integrated over each single grain is detected against the X-ray micro-diffraction pattern collected in transmission with a bi-dimensional detector. Furthermore, for galena grains rich in Zn, the XANES signal at the K-absorption edge of Zn shows its immediate nearest-neighbour environment

Synchrotron X-ray micro-beam studies of ancient Egyptian make-up

Science.gov (United States)

Martinetto, P.; Anne, M.; Dooryhée, E.; Drakopoulos, M.; Dubus, M.; Salomon, J.; Simionovici, A.; Walter, Ph.

2001-07-01

Vases full of make-up are most often present in the burial furniture of Egyptian tombs dated from the pharaonic period. The powdered cosmetics made of isolated grains are analysed to identify their trace element signature. From this signature we identify the provenance of the mineral ingredients in the make-up and we observe different impurities in products, which have been demonstrated as synthetic substances by previous works. Focused X-ray micro-beam ( 2×5 μm2) is successively tuned at 11 keV, below the L III absorption edge of Pb, and 31.8 keV for global characterisation of the metal impurities. The fluorescence signal integrated over each single grain is detected against the X-ray micro-diffraction pattern collected in transmission with a bi-dimensional detector. Furthermore, for galena grains rich in Zn, the XANES signal at the K-absorption edge of Zn shows its immediate nearest-neighbour environment.

Synchrotron X-ray micro-beam studies of ancient Egyptian make-up

Energy Technology Data Exchange (ETDEWEB)

Martinetto, P; Anne, M; Dooryhee, E; Drakopoulos, M; Dubus, M; Salomon, J; Simionovici, A; Walter, Ph

2001-07-01

Vases full of make-up are most often present in the burial furniture of Egyptian tombs dated from the pharaonic period. The powdered cosmetics made of isolated grains are analysed to identify their trace element signature. From this signature we identify the provenance of the mineral ingredients in the make-up and we observe different impurities in products, which have been demonstrated as synthetic substances by previous works. Focused X-ray micro-beam (2x5 {mu}m{sup 2}) is successively tuned at 11 keV, below the L{sub III} absorption edge of Pb, and 31.8 keV for global characterisation of the metal impurities. The fluorescence signal integrated over each single grain is detected against the X-ray micro-diffraction pattern collected in transmission with a bi-dimensional detector. Furthermore, for galena grains rich in Zn, the XANES signal at the K-absorption edge of Zn shows its immediate nearest-neighbour environment.

USGS Activities at Lake Roosevelt and the Upper Columbia River

Science.gov (United States)

Barton, Cynthia; Turney, Gary L.

2010-01-01

Lake Roosevelt (Franklin D. Roosevelt Lake) is the impoundment of the upper Columbia River behind Grand Coulee Dam, and is the largest reservoir within the Bureau of Reclamation's Columbia Basin Project (CBP). The reservoir is located in northeastern Washington, and stretches 151 miles from Grand Coulee Dam north to the Canadian border. The 15-20 miles of the Columbia River downstream of the border are riverine and are under small backwater effects from the dam. Grand Coulee Dam is located on the mainstem of the Columbia River about 90 miles northwest of Spokane. Since the late 1980s, trace-element contamination has been known to be widely present in Lake Roosevelt. Trace elements of concern include arsenic, cadmium, copper, lead, mercury, and zinc. Contaminated sediment carried by the Columbia River is the primary source of the widespread occurrence of trace-element enrichment present in Lake Roosevelt. In 2001, the U.S. Environmental Protection Agency (EPA) initiated a preliminary assessment of environmental contamination of the Lake Roosevelt area (also referred to as Upper Columbia River, UCR site, or UCR/LR site) and has subsequently begun remedial investigations of the UCR site.

University Research Initiative Program for Combat Readiness

Science.gov (United States)

1999-05-01

microscope image of one of the lenses. This array was selected for testing because it is fabricated in a relatively inexpensive polyacrylic material, the...potent analogues of the potassium -sparing diuretic, amiloride. However, our results 179 University Reasearch Initiative for Combat Readiness Annual Report...for Combat Readiness Annual Report for the period June 1, 1998 - June 30, 1999 Roger H. Sawyer University of South Carolina Columbia, SC 29208 May

Reconnaissance of contaminants in selected wastewater-treatment-plant effluent and stormwater runoff entering the Columbia River, Columbia River Basin, Washington and Oregon, 2008-10

Science.gov (United States)

Morace, Jennifer L.

2012-01-01

Toxic contamination is a significant concern in the Columbia River Basin in Washington and Oregon. To help water managers and policy makers in decision making about future sampling efforts and toxic-reduction activities, a reconnaissance was done to assess contaminant concentrations directly contributed to the Columbia River through wastewater-treatment-plant (WWTP) effluent and stormwater runoff from adjacent urban environments and to evaluate instantaneous loadings to the Columbia River Basin from these inputs.

Remedial Investigation of Hanford Site Releases to the Columbia River

International Nuclear Information System (INIS)

Lerch, J.A.

2009-01-01

In south-central Washington State, the Columbia River flows through the U.S. Department of Energy Hanford Site. A primary objective of the Hanford Site cleanup mission is protection of the Columbia River, through remediation of contaminated soil and groundwater that resulted from its weapons production mission. Within the Columbia River system, surface water, sediment, and biota samples related to potential Hanford Site hazardous substance releases have been collected since the start of Hanford operations. The impacts of Hanford Site hazardous substance releases to the Columbia River in areas upstream, within, and downstream of the Hanford Site boundary have been previously investigated as mandated by the U.S. Department of Energy requirements under the Atomic Energy Act. The impacts are now being assessed under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 via a remedial investigation. The Remedial Investigation Work Plan for Hanford Site Releases to the Columbia River has been developed and issued to initiate the remedial investigation. The work plan establishes a phased approach to characterize contaminants, assess current risks, and determine whether or not there is a need for any cleanup actions. Field investigation activities began in October 2008 and are anticipated to continue into Fall 2009 over a 120 mile stretch of the Columbia River. Information gained from performing this remedial investigation will ultimately be used to help make final regulatory decisions for cleaning up Hanford Site contamination that exists in and along the Columbia River. (authors)

The Columbia River System Inside Story

Energy Technology Data Exchange (ETDEWEB)

None

2001-04-01

The Columbia River is one of the greatest natural resources in the western United States. The river and its tributaries touch the lives of nearly every resident of the Pacific Northwest—from fostering world-famous Pacific salmon to supplying clean natural fuel for 50 to 65 percent of the region’s electrical generation. Since early in the 20th century, public and private agencies have labored to capture the benefits of this dynamic river. Today, dozens of major water resource projects throughout the region are fed by the waters of the Columbia Basin river system.

Column Experiments to Interpret Weathering in Columbia Hills

Science.gov (United States)

Hausrath, E. M.; Morris, R.V.; Ming, D.W.; Golden, D.C.; Galindo, C.; Sutter, B.

2009-01-01

Phosphate mobility has been postulated as an indicator of early aqueous activity on Mars. In addition, rock surfaces analyzed by the Mars Exploration Rover Spirit are consistent with the loss of a phosphate- containing mineral To interpret phosphate alteration behavior on Mars, we performed column dissolution experiments leaching the primary phases Durango fluorapatite, San Carlos olivine, and basalt glass (Stapafjell Volcano, courtesy of S. Gislason, University of Iceland) [3,4]) with acidic solutions. These phases were chosen to represent quickly dissolving phases likely present in Columbia Hills. Column dissolution experiments are closer to natural dissolution conditions than batch experiments, although they can be difficult to interpret. Acidic solutions were used because the leached layers on the surfaces of these rocks have been interpreted as resulting from acid solutions [5].

A new apparatus at hyper irradiation research facility at the Atomic Research Center, University of Tokyo

International Nuclear Information System (INIS)

Shibata, Hiromi; Iwai, Takeo; Narui, Makoto; Omata, Takao

1996-01-01

In the hyper irradiation research facility at the Atomic Research Center, the University of Tokyo, following apparatuses were newly installed for accelerator relating apparatus on 1995 fiscal year; 1) Hyper ion microbeam analysis apparatus, 2) Fourier conversion infrared microscopy, 3) Pico second two-dimensional fluorescence measuring apparatus, 4) Femto second wave-length reversible pulse laser radiation apparatus, and others. In addition to double irradiation, pulse beam irradiation experiment and so forth characteristic in conventional hyper irradiation research apparatus, upgrading of material irradiation experiments using these new apparatuses are intended. (G.K.)

A new apparatus at hyper irradiation research facility at the Atomic Research Center, University of Tokyo

Energy Technology Data Exchange (ETDEWEB)

Shibata, Hiromi; Iwai, Takeo; Narui, Makoto; Omata, Takao [Tokyo Univ. (Japan). Research Center for Nuclear Science and Technology

1996-12-01

In the hyper irradiation research facility at the Atomic Research Center, the University of Tokyo, following apparatuses were newly installed for accelerator relating apparatus on 1995 fiscal year; (1) Hyper ion microbeam analysis apparatus, (2) Fourier conversion infrared microscopy, (3) Pico second two-dimensional fluorescence measuring apparatus, (4) Femto second wave-length reversible pulse laser radiation apparatus, and others. In addition to double irradiation, pulse beam irradiation experiment and so forth characteristic in conventional hyper irradiation research apparatus, upgrading of material irradiation experiments using these new apparatuses are intended. (G.K.)

Flexoelectric Effect on Vibration of Piezoelectric Microbeams Based on a Modified Couple Stress Theory

Directory of Open Access Journals (Sweden)

Xingjia Li

2017-01-01

Full Text Available A novel electric Gibbs function was proposed for the piezoelectric microbeams (PMBs by employing a modified couple stress theory. Based on the new Gibbs function and the Euler-Bernoulli beam theory, the governing equations which incorporate the effects of couple stress, flexoelectricity, and piezoelectricity were derived for the mechanics of PMBs. The analysis of the effective bending rigidity shows the effects of size and flexoelectricity can greaten the stiffness of PMBs so that the natural frequency increases significantly compared with the Euler-Bernoulli beam, and then the mechanical and electrical properties of PMBs are enhanced compared to the classical beam. This study can guide the design of microscale piezoelectric/flexoelectric structures which may find potential applications in the microelectromechanical systems (MEMS.

Species for the screening assessment. Columbia River Comprehensive Impact Assessment

International Nuclear Information System (INIS)

Becker, J.M.; Brandt, C.A.; Dauble, D.D.; Maughan, A.D.; O'Neil, T.K.

1996-03-01

Because of past nuclear production operations along the Columbia River, there is intense public and tribal interest in assessing any residual Hanford Site related contamination along the river from the Hanford Reach to the Pacific Ocean. The Columbia River Comprehensive Impact Assessment was proposed to address these concerns. The assessment of the Columbia River is being conducted in phases. The initial phase is a screening assessment of the risk, which addresses current environmental conditions for a range of potential uses. One component of the screening assessment estimates the risk from contaminants in the Columbia River to the environment. The objective of the ecological risk assessment is to determine whether contaminants from the Columbia River pose a significant threat to selected receptor species that exist in the river and riparian communities of the study area. This report (1) identifies the receptor species selected for the screening assessment of ecological risk and (2) describes the selection process. The species selection process consisted of two tiers. In Tier 1, a master species list was developed that included many plant and animal species known to occur in the aquatic and riparian systems of the Columbia River between Priest Rapids Dam and the Columbia River estuary. This master list was reduced to 368 species that occur in the study area (Priest Rapids Dam to McNary Dam). In Tier 2, the 181 Tier 1 species were qualitatively ranked based on a scoring of their potential exposure and sensitivity to contaminants using a conceptual exposure model for the study area

Species for the screening assessment. Columbia River Comprehensive Impact Assessment

Energy Technology Data Exchange (ETDEWEB)

Becker, J.M.; Brandt, C.A.; Dauble, D.D.; Maughan, A.D.; O`Neil, T.K.

1996-03-01

Because of past nuclear production operations along the Columbia River, there is intense public and tribal interest in assessing any residual Hanford Site related contamination along the river from the Hanford Reach to the Pacific Ocean. The Columbia River Comprehensive Impact Assessment was proposed to address these concerns. The assessment of the Columbia River is being conducted in phases. The initial phase is a screening assessment of the risk, which addresses current environmental conditions for a range of potential uses. One component of the screening assessment estimates the risk from contaminants in the Columbia River to the environment. The objective of the ecological risk assessment is to determine whether contaminants from the Columbia River pose a significant threat to selected receptor species that exist in the river and riparian communities of the study area. This report (1) identifies the receptor species selected for the screening assessment of ecological risk and (2) describes the selection process. The species selection process consisted of two tiers. In Tier 1, a master species list was developed that included many plant and animal species known to occur in the aquatic and riparian systems of the Columbia River between Priest Rapids Dam and the Columbia River estuary. This master list was reduced to 368 species that occur in the study area (Priest Rapids Dam to McNary Dam). In Tier 2, the 181 Tier 1 species were qualitatively ranked based on a scoring of their potential exposure and sensitivity to contaminants using a conceptual exposure model for the study area.

Industrial natural gas supply options in British Columbia

International Nuclear Information System (INIS)

1994-01-01

Information is provided on the availability and cost of natural gas in British Columbia for use by firms interested in establishing gas-intensive industrial facilities in the province. British Columbia has an abundant supply of natural gas, originating mainly from deposits in the westernmost part of the Western Canadian Sedimentary Basin in the northeast part of the province. Recoverable resources in British Columbia are estimated at 1,000-1,400 billion m 3 . Over 200 producers compete to sell natural gas for both domestic and export markets. Gathering, processing, and transmission of the gas is undertaken mainly by the Westcoast Energy pipeline system, and distribution is undertaken by several distribution utilities. At present, all large industrial gas users buy their firm gas requirements directly from gas producers, often using gas marketers or brokers to assist in purchasing. Regulation of the gas industry is performed by the British Columbia Utilities Commission, which sets rules for energy supply contracts, and by the National Energy Board, which sets tolls for gathering, processing, and transporting gas. Factors affecting gas pricing are discussed, with reference to both the wellhead price and the cost of gathering, processing, and transportation. Firm gas costs for two hypothetical industrial loads in British Columbia are illustrated. Potential intensive uses of natural gas in the province are outlined, including power generation, liquefaction for export, manufacturing, production of direct reduced iron, and as petrochemical feedstocks. 5 figs., 2 tabs

Marketing wholesale electricity in British Columbia

Energy Technology Data Exchange (ETDEWEB)

Moghadam, B. [Powerex, Vancouver, BC (Canada)

2002-03-14

An open access wholesale transmission tariff (WTS) has been in place in British Columbia since 1997, and wholesale electricity can be sold to wholesale purchasers by independent producers located within the province. Customers range from municipalities to British Columbia Hydro (BC Hydro), to Powerex, to UtiliCorp Networks Corporation (UNC). Provided that the necessary approvals and transmission services have been acquired, the energy may be transmitted anywhere in Canada or the United States. The generation and sale of electricity within British Columbia and the United States is subject to government and regulatory approvals. Several buyers and sellers that come together to trade a product are part of a hub. The largest such hub in the Pacific Northwest is called the Mid-Columbia (Mid-C) hub in Washington. The commodity is traded in 25 MW standard blocks. The credit requirements of the purchaser must be satisfied by the generating party. BC Hydro wholesale transmission service can be purchased by any wholesale power marketer or generator to transmit the power to market. It is imperative that scheduling personnel be available at all times. The Western System Coordinating Council (WSCC) insists that an operating reserve of 5 per cent hydro generation and 7 per cent thermal generation to support the electrical system in the face of an emergency be available for the electricity marketed through the hub. Powerex has been successful since 1988 in the marketing of electricity throughout the WSCC. An example was provided to help make the rules a bit easier to comprehend. refs.

Marketing wholesale electricity in British Columbia

International Nuclear Information System (INIS)

Moghadam, B.

2002-01-01

An open access wholesale transmission tariff (WTS) has been in place in British Columbia since 1997, and wholesale electricity can be sold to wholesale purchasers by independent producers located within the province. Customers range from municipalities to British Columbia Hydro (BC Hydro), to Powerex, to UtiliCorp Networks Corporation (UNC). Provided that the necessary approvals and transmission services have been acquired, the energy may be transmitted anywhere in Canada or the United States. The generation and sale of electricity within British Columbia and the United States is subject to government and regulatory approvals. Several buyers and sellers that come together to trade a product are part of a hub. The largest such hub in the Pacific Northwest is called the Mid-Columbia (Mid-C) hub in Washington. The commodity is traded in 25 MW standard blocks. The credit requirements of the purchaser must be satisfied by the generating party. BC Hydro wholesale transmission service can be purchased by any wholesale power marketer or generator to transmit the power to market. It is imperative that scheduling personnel be available at all times. The Western System Coordinating Council (WSCC) insists that an operating reserve of 5 per cent hydro generation and 7 per cent thermal generation to support the electrical system in the face of an emergency be available for the electricity marketed through the hub. Powerex has been successful since 1988 in the marketing of electricity throughout the WSCC. An example was provided to help make the rules a bit easier to comprehend. refs

78 FR 37222 - Columbia Organic Chemical Company Site, Columbia, Richland County, South Carolina; Notice of...

Science.gov (United States)

2013-06-20

... Protection Agency (EPA). ACTION: Notice of Settlement. SUMMARY: Under 122(h) of the Comprehensive... Agency has entered into a settlement with Stephen Reichlyn concerning the Columbia Organic Chemical...

Human scenarios for the screening assessment. Columbia River Comprehensive Impact Assessment

Energy Technology Data Exchange (ETDEWEB)

Napier, B.A.; Harper, B.L.; Lane, N.K.; Strenge, D.L.; Spivey, R.B.

1996-03-01

Because of past nuclear production operations along the Columbia River, there is intense public and tribal interest in assessing any residual Hanford Site related contamination along the river from the Hanford Reach to the Pacific Ocean. The Columbia River Impact Assessment (CRCIA) was proposed to address these concerns. The assessment of the Columbia River is being conducted in phases. The initial phase is a screening assessment of risk, which addresses current environmental conditions for a range of potential uses. One component of the screening assessment estimates the risk from contaminants in the Columbia River to humans. Because humans affected by the Columbia river are involved in a wide range of activities, various scenarios have been developed on which to base the risk assessments. The scenarios illustrate the range of activities possible by members of the public coming in contact with the Columbia River so that the impact of contaminants in the river on human health can be assessed. Each scenario illustrates particular activity patterns by a specific group. Risk will be assessed at the screening level for each scenario. This report defines the scenarios and the exposure factors that will be the basis for estimating the potential range of risk to human health from Hanford-derived radioactive as well as non-radioactive contaminants associated with the Columbia River.

Human scenarios for the screening assessment. Columbia River Comprehensive Impact Assessment

International Nuclear Information System (INIS)

Napier, B.A.; Harper, B.L.; Lane, N.K.; Strenge, D.L.; Spivey, R.B.

1996-03-01

Because of past nuclear production operations along the Columbia River, there is intense public and tribal interest in assessing any residual Hanford Site related contamination along the river from the Hanford Reach to the Pacific Ocean. The Columbia River Impact Assessment (CRCIA) was proposed to address these concerns. The assessment of the Columbia River is being conducted in phases. The initial phase is a screening assessment of risk, which addresses current environmental conditions for a range of potential uses. One component of the screening assessment estimates the risk from contaminants in the Columbia River to humans. Because humans affected by the Columbia river are involved in a wide range of activities, various scenarios have been developed on which to base the risk assessments. The scenarios illustrate the range of activities possible by members of the public coming in contact with the Columbia River so that the impact of contaminants in the river on human health can be assessed. Each scenario illustrates particular activity patterns by a specific group. Risk will be assessed at the screening level for each scenario. This report defines the scenarios and the exposure factors that will be the basis for estimating the potential range of risk to human health from Hanford-derived radioactive as well as non-radioactive contaminants associated with the Columbia River

77 FR 58126 - Columbia Gas Transmission, LLC; Notice of Offer of Settlement

Science.gov (United States)

2012-09-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RP12-1021-000] Columbia Gas Transmission, LLC; Notice of Offer of Settlement Take notice that on September 4, 2012, Columbia Gas Transmission, LLC (Columbia) filed a Stipulation and Agreement (Settlement), including pro forma tariff records...

Submission to the British Columbia government on the Kyoto Protocol

International Nuclear Information System (INIS)

2002-09-01

The Business Council provided its comments concerning the Kyoto Protocol and climate change to the government of British Columbia, recommending that a clear position be established quickly on the matter. The adopted position should also be disseminated broadly to allow stake holders sufficient time to prepare for the upcoming meetings of the Joint Ministers and First Ministers. The federal government has announced that the decision on whether to ratify the Kyoto Protocol will be made before the end of 2002, and this decision will have numerous effects on the people of British Columbia, businesses, workers, and consumers alike. The Business Council of British Columbia believes that the unique interests of the province can best be protected by a proactive approach. Actions plans are being prepared by several of the other provinces and territories, who have already stated their position concerning the Kyoto Protocol. The long-term risks of climate change for British Columbia have not been determined nor have the elements of a provincial approach. The following elements should be included in British Columbia's position on the Kyoto Protocol, according to the Business Council of British Columbia: (1) a credible and cost-effective implementation plan that does not unduly burden the province and other jurisdictions must be developed before Canada decides to ratify the Protocol. British Columbia should go on the record stating it does not support the ratification of the Kyoto Protocol in its present form. (2) the province should advocate for a national approach to climate change that can be achieved within a reasonable time frame, reflects the long-term nature of the problem, and is in agreement with the economic development objectives of British Columbia, (3) a plan detailing how the province intends to deal with the growth of greenhouse gas emissions should supplement and support the position of the province on the Kyoto Protocol. Consumers and business should be engaged

Oil and gas in British Columbia : 10 steps to responsible development

International Nuclear Information System (INIS)

2004-04-01

The British Columbia government has proposed to double production of oil and gas, the burning of which causes global warming. West Coast Environmental Law (WCEL) claims there is a strong divide between British Columbia's plans to expand the production and use of fossil fuels, and the international scientific consensus regarding the negative aspects of global warming. The impacts of oil and gas production negatively affect the health of local citizens, First Nations rights and the environment. Offshore oil and gas development could also threaten fisheries and pollute sensitive marine ecosystems. WCEL criticizes the fact that the British Columbia government has streamlined environmental regulations, has laid off compliance monitoring staff, and has given subsidies to the highly profitable oil and gas industry. WCEL argues that the impact of fossil fuel production must be mitigated to limit the damage to lands and people in British Columbia. The organization has proposed 10 recommendations to the British Columbia government. The recommendations focus on impacts of land-based oil and gas development rather than offshore impacts. WCEL claims that adoption of the 10-point mitigation plan is vital for putting British Columbia on the path toward sustainable development. 43 refs

The Columbia River System : the Inside Story.

Energy Technology Data Exchange (ETDEWEB)

United States. Bonneville Power Administration.

1991-09-01

The Columbia Ricer is one of the greatest natural resources in the western United States. The river and its tributaries touch the lives of nearly every resident of the Northwest-from providing the world-famous Pacific salmon to supplying the clean natural fuel for over 75 percent of the region's electrical generation. Since early in the century, public and private agencies have labored to capture the benefits of this dynamic river. Today, dozens of major water resource projects throughout the region are fed by the waters of the Columbia Basin river system. And through cooperative efforts, the floods that periodically threaten developments near the river can be controlled. This publication presents a detailed explanation of the planning and operation of the multiple-use dams and reservoirs of the Columbia River system. It describes the river system, those who operate and use it, the agreements and policies that guide system operation, and annual planning for multiple-use operation.

Lower Columbia River and Estuary Habitat Monitoring Study, 2011 - Final Report

Energy Technology Data Exchange (ETDEWEB)

Borde, Amy B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kaufmann, Ronald M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Cullinan, Valerie I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zimmerman, Shon A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Thom, Ronald M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wright, Cynthia L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2012-03-01

The Ecosystem Monitoring Program is a collaborative effort between the Lower Columbia River Estuary Partnership (LCREP), University of Washington, Wetland Ecosystem Team (UW), US Geological Survey, Water Science Center (USGS), National Oceanic and Atmospheric Administration, National Marine Fisheries Service (NOAA-Fisheries, hereafter NOAA), and Pacific Northwest National Laboratory, Marine Sciences Laboratory (PNNL). The goal of the program is to conduct emergent wetland monitoring aimed at characterizing salmonid habitats in the lower Columbia River and estuary (LCRE) from the mouth of the estuary to Bonneville Dam (Figure 1). This is an ecosystem based monitoring program focused on evaluating status and trends in habitat and reducing uncertainties regarding these ecosystems to ultimately improve the survival of juvenile salmonids through the LCRE. This project comprehensively assesses habitat, fish, food web, and abiotic conditions in the lower river, focusing on shallow water and vegetated habitats used by juvenile salmonids for feeding, rearing and refugia. The information is intended to be used to guide management actions associated with species recovery, particularly that of threatened and endangered salmonids. PNNL’s role in this multi-year study is to monitor the habitat structure (e.g., vegetation, topography, channel morphology, and sediment type) as well as hydrologic patterns.

British Columbia offshore oil and gas socio-economic issue papers

International Nuclear Information System (INIS)

Boydell, T.; Brar, C.; Dodd, M.; Kwong, N.; Seeley

2004-05-01

Some of the key social and economic issues regarding offshore oil and gas exploration and development in British Columbia's coastal waters were examined by the Science, Technology and Environment Division of Royal Roads University in conjunction with Glenn Bridges and Associates. In 1972, the federal government imposed a moratorium to prevent crude oil tankers from travelling the west coast due to concerns over environmental impacts. A provincial moratorium on exploration followed shortly thereafter. The government of British Columbia recently suggested lifting the moratorium, and conducted public hearings and scientific reviews of issues related to offshore oil and exploration. In the Spring of 2002, the provincial government asked the federal government to consider lifting its moratorium. In response, a Federal Interdepartmental Offshore Oil and Gas Socio-Economic Issues Working Group conducted a series of study plans in the areas of science, legal, aboriginal, socio-economic, oceans and management regimes. This report provides the outcomes of the studies. It is organized in tabular form to facilitate presentation. All 8 tabs were catalogued separately for inclusion in this database. They include: (1) an introduction and overview, (2) illustrative development scenarios, (3) resource revenues report, (4) socio-economic expenditure report, (5) human resources report, (6) due diligence issues report, (7) knowledge management strategy for policy formation, and, (8) bibliography. refs., tabs., figs

British Columbia offshore oil and gas socio-economic issue papers

Energy Technology Data Exchange (ETDEWEB)

Boydell, T.; Brar, C.; Dodd, M.; Kwong, N.; Seeley [Royal Roads Univ., Victoria, BC (Canada). Science Technology and Environment Division; Bridges, G.; Shrimpton, M.; Burke, H.; Johnson, J. [GE Bridges and Associates, Victoria, BC (Canada)

2004-05-01

Some of the key social and economic issues regarding offshore oil and gas exploration and development in British Columbia's coastal waters were examined by the Science, Technology and Environment Division of Royal Roads University in conjunction with Glenn Bridges and Associates. In 1972, the federal government imposed a moratorium to prevent crude oil tankers from travelling the west coast due to concerns over environmental impacts. A provincial moratorium on exploration followed shortly thereafter. The government of British Columbia recently suggested lifting the moratorium, and conducted public hearings and scientific reviews of issues related to offshore oil and exploration. In the Spring of 2002, the provincial government asked the federal government to consider lifting its moratorium. In response, a Federal Interdepartmental Offshore Oil and Gas Socio-Economic Issues Working Group conducted a series of study plans in the areas of science, legal, aboriginal, socio-economic, oceans and management regimes. This report provides the outcomes of the studies. It is organized in tabular form to facilitate presentation. All 8 tabs were catalogued separately for inclusion in this database. They include: (1) an introduction and overview, (2) illustrative development scenarios, (3) resource revenues report, (4) socio-economic expenditure report, (5) human resources report, (6) due diligence issues report, (7) knowledge management strategy for policy formation, and, (8) bibliography. refs., tabs., figs.

The Interior Columbia Basin Ecosystem Management Project: scientific assessment.

Science.gov (United States)

1999-01-01

This CD-ROM contains digital versions (PDF) of the major scientific documents prepared for the Interior Columbia Basin Ecosystem Management Project (ICBEMP). "A Framework for Ecosystem Management in the Interior Columbia Basin and Portions of the Klamath and Great Basins" describes a general planning model for ecosystem management. The "Highlighted...

Ecology of Juvenile Salmon in Shallow Tidal Freshwater Habitats in the Vicinity of the Sandy River Delta, Lower Columbia River, 2008

Energy Technology Data Exchange (ETDEWEB)

Sather, Nichole K.; Johnson, Gary E.; Storch, Adam; Teel, David; Skalski, John R.; Jones, Tucker A.; Dawley, Earl M.; Zimmerman, Shon A.; Borde, Amy B.; Mallette, Christine; Farr, R.

2009-05-29

The tidal freshwater monitoring (TFM) project reported herein is part of the research, monitoring, and evaluation effort developed by the Action Agencies (Bonneville Power Administration, the U.S. Army Corps of Engineers [USACE], and the U.S. Bureau of Reclamation) in response to obligations arising from the Endangered Species Act (ESA) as a result of operation of the Federal Columbia River Power System. The project is being performed under the auspices of the Northwest Power and Conservation Council’s Columbia Basin Fish and Wildlife Program (Project No. 2005-001-00). The research is a collaborative effort among the Pacific Northwest National Laboratory, the Oregon Department of Fish and Wildlife, the National Marine Fisheries Service, and the University of Washington.

Geologic studies of the Columbia Plateau: a status report

International Nuclear Information System (INIS)

Myers, C.W.; Price, S.M.

1979-10-01

The results of recent geologic studies of the Columbia Plateau, with emphasis on work completed under the Basalt Waste Isolation Project, Rockwell Hanford Operations, are summarized in this report. Geologic studies were performed mostly during the period from 1977 to 1979. The major objective of these studies was to examine the feasibility of using deep underground tunnels mined into Columbia River basalt beneath the Hanford Site for final storage of nuclear waste. The results are presented in four chapters: Introduction; Regional Geology; Pasco Basin Geology; and Seismicity and Tectonics. Results from surface mapping and remote sensing studies in the Washington State portion of the Columbia Plateau are presented in the Regional Geology chapter. Results from surface mapping, borehole studies, and geophysical surveys in the Pasco Basin are presented in the Pasco Basin Geology chapter. Results that relate to the tectonic stability of the Pasco Basin and Columbia Plateau and discussion of findings from earthquake monitoring in the region for the past ten years are summarized in the Seismicity and Tectonics chapter. A volume of Appendices is included. This volume contains a description of study tasks, a description of the methodology used in geophysical surveys the geophysical survey results, a summary of earthquake records in eastern Washington, a description of tectonic provinces, and a preliminary description of the regional tectonic setting of the Columbia Plateau

Taxonomic status of the Columbia duskysnail (Truncatelloidea, Amnicolidae, Colligyrus).

Science.gov (United States)

Liu, Hsiu-Ping; Hershler, Robert; Rossel, Christopher S

2015-01-01

Undescribed freshwater snails (Amnicolidae: Colligyrus) from the Mount Hood region (northwestern United States) identified as a new species (commonly known as the Columbia duskysnail) in grey literature have been provided federal protection under the "survey and manage" provisions of the Northwest Forest Plan and have been placed on conservation watch lists. However, there are no published studies of the identity of these snails aside from a molecular phylogenetic analysis which delineated a close relationship between the single sampled population and Colligyrusgreggi, which is distributed more than 750 km to the east of the Mount Hood area. Here we examine the taxonomic status of the Columbia duskysnail based on additional molecular sampling of mitochondrial DNA sequences (COI) and morphological evidence. We found that the Columbia duskysnail is not a monophyletic group and forms a strongly supported clade with Colligyrusgreggi. The COI divergence between these broadly disjunct groups (2.1%) was somewhat larger than that within Colligyrusgreggi (1.0%) but considerably less than that among the three currently recognized species of Colligyrus (8.7-12.1%). Additionally we found that the Columbia duskysnail and Colligyrusgreggi cannot be consistently differentiated by previously reported diagnostic characters (size and shape of shell spire, pigmentation of body and penis) and are closely similar in other aspects of morphology. Based on these results we conclude that the Columbia duskysnail is conspecific with Colligyrusgreggi.

Ecosystem-level changes that may be expected in a changing global climate - a British Columbia perspective. [Canada - British Columbia

Energy Technology Data Exchange (ETDEWEB)

Kimmins, J.P.; Lavender, D.P. (Univ. of British Columbia, Vancouver, BC (Canada). Dept. of Forest Science)

1992-08-01

British Columbia is a vast province encompassing a wide latitudinal and elevational range. Four of the five major classes of climate in the world are found in British Columbia, where prevailing westerly winds from the Pacific and a series of north-south mountain ranges have produced widely differing local climates. The predicted global warming may result in the migration of species and communities upslope and toward the north, but the heterogenous nature of the present landscape suggests that such migration may not be as pronounced as that likely to occur in regions of Canada with less relief. Effects of climatic warming on long-lived temperate zone trees include possible increased frost damage in early spring; reduced seed production; increased insect and disease incidence; increased damage to forests by wildfire; and, in the warmer parts of coastal British Columbia, a winter climate too warm to satisfy the chilling requirements of some perennial plants.

X-ray microbeam measurements of long-range internal stresses in commercial-purity aluminum processed by multiple passes of equal-channel angular pressing

International Nuclear Information System (INIS)

Phan, Thien Q.; Lee, I-Fang; Levine, Lyle E.; Tischler, Jonathan Z.; Huang, Yi; Fox, Alan G.; Langdon, Terence G.; Kassner, Michael E.

2014-01-01

X-ray microbeam diffraction was used to measure long-range internal stresses (LRISs) in the grain/subgrain interiors of commercial-purity aluminum processed by equal-channel angular pressing for up to eight passes. The LRIS values at +4.9° off the axial (pressing) direction show only a slight increase with increasing numbers of passes. The normalized stress remains approximately constant at ∼0.10 of the flow stress

Establishing the suitability of quantitative optical CT microscopy of PRESAGE® radiochromic dosimeters for the verification of synchrotron microbeam therapy

Science.gov (United States)

Doran, Simon J.; Rahman, A. T. Abdul; Bräuer-Krisch, Elke; Brochard, Thierry; Adamovics, John; Nisbet, Andrew; Bradley, David

2013-09-01

Previous research on optical computed tomography (CT) microscopy in the context of the synchrotron microbeam has shown the potential of the technique and demonstrated high quality images, but has left two questions unanswered: (i) are the images suitably quantitative for 3D dosimetry? and (ii) what is the impact on the spatial resolution of the system of the limited depth-of-field of the microscope optics? Cuvette and imaging studies are reported here that address these issues. Two sets of cuvettes containing the radiochromic plastic PRESAGE® were irradiated at the ID17 biomedical beamline of the European Synchrotron Radiation facility over the ranges 0-20 and 0-35 Gy and a third set of cuvettes was irradiated over the range 0-20 Gy using a standard medical linac. In parallel, three cylindrical PRESAGE® samples of diameter 9.7 mm were irradiated with test patterns that allowed the quantitative capabilities of the optical CT microscope to be verified, and independent measurements of the imaging modulation transfer function (MTF) to be made via two different methods. Both spectrophotometric analysis and imaging gave a linear dose response, with gradients ranging from 0.036-0.041 cm-1 Gy-1 in the three sets of cuvettes and 0.037 (optical CT units) Gy-1 for the imaging. High-quality, quantitative imaging results were obtained throughout the 3D volume, as illustrated by depth-dose profiles. These profiles are shown to be monoexponential, and the linear attention coefficient of PRESAGE® for the synchrotron-generated x-ray beam is measured to be (0.185 ± 0.02) cm-1 in excellent agreement with expectations. Low-level (<5%) residual image artefacts are discussed in detail. It was possible to resolve easily slit patterns of width 37 µm (which are smaller than many of the microbeams used on ID-17), but some uncertainty remains as to whether the low values of MTF for the higher spatial frequencies are scanner related or a result of genuine (but non-ideal) dose

77 FR 3115 - Safety Zone; Grain-Shipment Vessels, Columbia and Snake Rivers

Science.gov (United States)

2012-01-23

...-AA00 Safety Zone; Grain-Shipment Vessels, Columbia and Snake Rivers AGENCY: Coast Guard, DHS. ACTION... Terminal, Longview, WA, while they are located on the Columbia and Snake Rivers. This safety zone extends... on the Columbia and Snake rivers when vessels begin arriving at EGT, Longview, WA. Under 5 U.S.C. 553...

Geothermal prospects in British Columbia: Resource, market and regulatory aspects

International Nuclear Information System (INIS)

Ghomshei, M.M.; Brown, T.L.S.; MacRae, J.M.

1992-01-01

British Columbia is host to about 15 young volcanic centres and 60 hot springs, all evidence of presence of geothermal resources. Most high-grade geothermal prospects in British Columbia are located along 3 volcanic belts in the south-western region of the province. It is estimated that a minimum of 800 MWe can be generated from the known prospects in this region. Significant low-grade geothermal resources exist in several provincial regions. Market applications consistent with the geothermal resources known and expected to occur in British Columbia include electrical generation, process and other direct heat uses and recreation. Leasing, exploration and development operations for high-grade geothermal resources are addressed by the British Columbia open-quotes Geothermal Resources Actclose quotes which defines geothermal resources and reserves all rights to the Crown in the right of the Province

A 3 MV pelletron at Fudan University

International Nuclear Information System (INIS)

Sun Chuanchen; Lu Chengrong; Fe Zhiyu; Yuan Daosheng

1989-01-01

A 3 MV Pelletron tandem, model 9SDH-2, the fourth machine manufactured by NEC was installed and has been operating at Fudan University since 1987. The operating experiences obtained during the past year are described. Three beam lines have been established: one is for Auger-ESCA and RBS in an ultrahigh-vacuum chamber in which Al(100) clean surfaces have been studied; the second beam line is used as a microbeam analysis system using a 2 μm proton beam for resonant prefitting studies. The third is a general purpose beam line, for studies of the effect of nuclear resonance on K X-ray yield. At present, the third beam line is also used for ion beam analysis studies of 8.8 MeV He 2+ non-Rutherford scattering on high T c superconductors. (orig.)

Liftoff of Space Shuttle Columbia on mission STS-93

Science.gov (United States)

1999-01-01

The fiery launch of Space Shuttle Columbia lights up the night sky on its successful liftoff from Launch Pad 39-B on mission STS-93. Liftoff occurred at 12:31 a.m. EDT. STS-93 is a five-day mission primarily to release the Chandra X-ray Observatory, which will allow scientists from around the world to study some of the most distant, powerful and dynamic objects in the universe. The crew numbers five: Commander Eileen M. Collins, Pilot Jeffrey S. Ashby, and Mission Specialists Stephen A. Hawley (Ph.D.), Catherine G. Coleman (Ph.D.) and Michel Tognini of France, with the Centre National d'Etudes Spatiales (CNES). Collins is the first woman to serve as commander of a Shuttle mission. The target landing date is July 27, 1999, at 11:20 p.m. EDT.

A comparison of ray-tracing software for the design of quadrupole microbeam systems

International Nuclear Information System (INIS)

Incerti, S.; Smith, R.W.; Merchant, M.; Grime, G.W.; Meot, F.; Serani, L.; Moretto, Ph.; Touzeau, C.; Barberet, Ph.; Habchi, C.; Nguyen, D.T.

2005-01-01

For many years the only ray-tracing software available with sufficient precision for the design of quadrupole microbeam focusing systems has been OXRAY and its successor TRAX, developed at Oxford in the 1980s. With the current interest in pushing the beam diameter into the nanometre region, this software has become dated and more importantly the precision at small displacements may not be sufficient and new simulation tools are required. Two candidates for this are Zgoubi, developed at CEA as a general beam line design tool and the CERN simulation program Geant in its latest version Geant4. In order to use Geant4 new quadrupole field modules have been developed and implemented. In this paper the capabilities of the three codes TRAX, Zgoubi and Geant4 are reviewed. Comparisons of ray-tracing calculations in a high demagnification quadrupole probe-forming system for the sub-micron region are presented

76 FR 60852 - District of Columbia; Emergency and Related Determinations

Science.gov (United States)

2011-09-30

...: I have determined that the emergency conditions in the District of Columbia resulting from Hurricane... District of Columbia to have been adversely affected by this declared emergency: Emergency protective....046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to Individuals and...

Taxonomic status of the Columbia duskysnail (Truncatelloidea, Amnicolidae, Colligyrus

Directory of Open Access Journals (Sweden)

Hsiu-Ping Liu

2015-07-01

Full Text Available Undescribed freshwater snails (Amnicolidae: Colligyrus from the Mount Hood region (northwestern United States identified as a new species (commonly known as the Columbia duskysnail in grey literature have been provided federal protection under the “survey and manage” provisions of the Northwest Forest Plan and have been placed on conservation watch lists. However, there are no published studies of the identity of these snails aside from a molecular phylogenetic analysis which delineated a close relationship between the single sampled population and C. greggi, which is distributed more than 750 km to the east of the Mount Hood area. Here we examine the taxonomic status of the Columbia duskysnail based on additional molecular sampling of mitochondrial DNA sequences (COI and morphological evidence. We found that the Columbia duskysnail is not a monophyletic group and forms a strongly supported clade with C. greggi. The COI divergence between these broadly disjunct groups (2.1% was somewhat larger than that within C. greggi (1.0% but considerably less than that among the three currently recognized species of Colligyrus (8.7–12.1%. Additionally we found that the Columbia duskysnail and C. greggi cannot be consistently differentiated by previously reported diagnostic characters (size and shape of shell spire, pigmentation of body and penis and are closely similar in other aspects of morphology. Based on these results we conclude that the Columbia duskysnail is conspecific with C. greggi.

Dynamics of an Imperfect Microbeam Considering its Exact Shape

KAUST Repository

Bataineh, Ahmad M.

2014-08-17

We study the static and dynamic behavior of electrically actuated micromachined arches. First, we conduct experiments on micromachined polysilicon beams by driving them electrically and varying their amplitude and frequency of voltage loads. The results reveal several interesting nonlinear phenomena of jumps, hysteresis, and softening behaviors. Next, we conduct analytical and theoretical investigation to understand the experiments. First, we solve the Eigen value problem analytically. We study the effect of the initial rise on the natural frequency and mode shapes, and use a Galerkin-based procedure to derive a reduced order model, which is then used to solve both the static and dynamic responses. We use two symmetric modes in the reduced order model to have accurate and converged results. We use long time integration to solve the nonlinear ordinary differential equations, and then modify our model using effective length to match experimental results. To further improve the matching with the experimental data, we curve-fit the exact profile of the microbeam to match the experimentally measured profile and use it in the reduced-order model to generate frequency-response curves. Finally, we use another numerical technique, the shooting technique, to solve the nonlinear ordinary differential equations. By using shooting and the curve fitted function, we found that we get good agreement with the experimental data.

Foreign students, visitors and immigration to British Columbia.

Science.gov (United States)

Kunin, R

1993-01-01

"This report has provided a brief outline of business immigration to Canada and to British Columbia from several source countries in the Asian Pacific Rim. The importance of business immigration to Canada in general, and British Columbia in particular, is [examined].... Even with the limited data currently available, this brief study indicates a very high statistical relationship between business immigration and other less formal and less permanent movements of people such as student flows and visitors." excerpt

Data Compendium for the Columbia River comprehensive impact assessment

International Nuclear Information System (INIS)

Eslinger, P.W.; Huesties, L.R.; Maughan, A.D.; Miley, T.B.; Walters, W.H.

1994-04-01

The Columbia River Comprehensive Impact Assessment (CRCIA). The CRCIA is conducted by the Pacific Northwest Laboratory (PNL). The purpose of the CRCIA is to evaluate the current human and ecological risk from the Columbia River attributable to past and present activities on the Hanford Site. Human risk will be addressed for radioactive and hazardous materials over a range of river use options. Ecological risk will be evaluated relative to the health of the current river ecosystem. The initial effort for the CRCIA is the development of a compendium of existing data on Columbia River contamination. This document provides the data compendium. It also includes a discussion of data sources, descriptions of the physical format of the data, and descriptions of the search process used to identify data

The Institutionalization of NSF-ADVANCE at Lamont-Doherty Earth Observatory, Columbia University

Science.gov (United States)

Dutt, K.

2011-12-01

National level data indicate that women and minorities remain underrepresented in academic and research institutions, especially in the physical sciences. Current research shows evidence of "leaks" in the academic pipeline with women leaving academic and research institutions before attaining senior positions, the biggest leak occurring during postdoctoral years. These trends have been consistent with the LDEO experience with approximately 18% women at the junior scientist level in 2005 - a massive drop-off after approximately 41% women at the postdoctoral level. As a response to the recommendations of ADVANCE at Columbia University (2004-2009) the Office of Academic Affairs and Diversity was created within the LDEO Directorate in 2008 with the goal of increasing diversity through institutional transformation. The goals of this office are to: a) Develop and implement new policies and procedures to increase the recruitment, retention and advancement of women and minorities among the scientific staff; b) Impact key decision-making areas such as appointments, promotions, salary structures, and governance; c) Promote the advancement of postdoctoral scholars and junior staff; d) Stimulate an institutional cultural shift based on social science research on race and gender. A series of concerted efforts and initiatives in recent years have included: a) More structured search processes; b) Improved family leave policies and paid time off; c) Emphasis on advancement of postdoctoral scholars, including the implementation of a postdoctoral mentoring plan; and d) Promoting awareness within the LDEO community on diversity in the sciences. In recent years LDEO has experienced visible progress towards its diversity goals. The proportion of women among junior Lamont research professors has doubled from 18% in 2005 to 36% in 2011. The proportion of women on the junior scientific staff (excluding postdoctoral scholars) increased from 22% in 2005 to 37% in 2011. Overall, the

The Columbia Non-neutral Torus

International Nuclear Information System (INIS)

Pedersen, Thomas Sunn

2009-01-01

Final report for the Columbia Non-neutral Torus. This details the results from the design, construction and initial operation of the Columbia Non-neutral Torus. During the duration of this grant, I designed, built, and operated the Columbia Nonneutral Torus, the world's lowest aspect ratio stellarator, and arguably, the world's simplest stellarator. This demonstrates the ease and robustness of the chosen stellarator design and allowed us to commence the investigation of the physics of non-neutral plasmas confined on magnetic surfaces. These plasmas are unique in many ways and had not previously been studied in a stellarator. Our first results showed that it is possible to confine and study a relatively cold pure electron plasma in a stellarator. We confirmed that the plasma is stable, and that the plasma is reasonably well confined in a stellarator configuration. These results were published in Physics of Plasmas (2006) and Physical Review Letters (2006). They enabled the existing program which is resolving the underlying transport processes in a classical stellarator with intense self-electric fields and enable the next phase of operation, electron-positron plasma physics. During the period of this grant, two students were trained in experimental plasma physics and both received their PhD degrees shortly after the grant terminated. One student is now employed in the financial services industry, the other is a postdoctoral associate at Los Alamos National Laboratory. The chief goals were to build and begin operation of the Columbia Non-neutral Torus. These goals were achieved in the third year of funding. The development of diagnostic methods and the confirmation of stable equilibria were also achieved during the grant period. In summary, the main scientific goals were all met. The main educational goals were also met, as the experiment became the training ground not only for the two aforementioned graduate students but also for a number of undergraduate students

78 FR 3893 - Columbia Gas Transmission, LLC; Notice of Request Under Blanket Authorization

Science.gov (United States)

2013-01-17

... any natural gas service; however, Columbia would terminate service to one free gas customer pursuant to the terms of the lease agreement between the customer and Columbia. Columbia estimates that it... contact FERC Online Support at FERC Online[email protected] or call toll-free at (866) 206-3676, or, for...

Union-Active School Librarians and School Library Advocacy: A Modified Case Study of the British Columbia Teacher-Librarians' Association and the British Columbia Teachers' Federation

Science.gov (United States)

Ewbank, Ann Dutton

2015-01-01

This modified case study examines how the members of the British Columbia Teacher-Librarians' Association (BCTLA), a Provincial Specialist Association (PSA) of the British Columbia Teachers' Federation (BCTF), work together to advocate for strong school library programs headed by a credentialed school librarian. Since 2002, despite nullification…

DC dynamic pull-in predictions for a generalized clamped–clamped micro-beam based on a continuous model and bifurcation analysis

International Nuclear Information System (INIS)

Chao, Paul C-P; Chiu, C W; Liu, Tsu-Hsien

2008-01-01

This study is devoted to providing precise predictions of the dc dynamic pull-in voltages of a clamped–clamped micro-beam based on a continuous model. A pull-in phenomenon occurs when the electrostatic force on the micro-beam exceeds the elastic restoring force exerted by beam deformation, leading to contact between the actuated beam and bottom electrode. DC dynamic pull-in means that an instantaneous application of the voltage (a step function such as voltage) is applied. To derive the pull-in voltage, a dynamic model in partial differential equations is established based on the equilibrium among beam flexibility, inertia, residual stress, squeeze film, distributed electrostatic forces and its electrical field fringing effects. The method of Galerkin decomposition is then employed to convert the established system equations into reduced discrete modal equations. Considering lower-order modes and approximating the beam deflection by a different order series, bifurcation based on phase portraits is conducted to derive static and dynamic pull-in voltages. It is found that the static pull-in phenomenon follows dynamic instabilities, and the dc dynamic pull-in voltage is around 91–92% of the static counterpart. However, the derived dynamic pull-in voltage is found to be dependent on the varied beam parameters, different from a fixed predicted value derived in past works, where only lumped models are assumed. Furthermore, accurate closed-form predictions are provided for non-narrow beams. The predictions are finally validated by finite element analysis and available experimental data

Evaluating Cumulative Ecosystem Response to Restoration Projects in the Lower Columbia River and Estuary, 2009

Energy Technology Data Exchange (ETDEWEB)

Johnson, Gary E.; Diefenderfer, Heida L.; Borde, Amy B.; Bryson, Amanda J.; Cameron, April; Coleman, Andre M.; Corbett, C.; Dawley, Earl M.; Ebberts, Blaine D.; Kauffman, Ronald; Roegner, G. Curtis; Russell, Micah T.; Silva, April; Skalski, John R.; Thom, Ronald M.; Vavrinec, John; Woodruff, Dana L.; Zimmerman, Shon A.

2010-10-26

This is the sixth annual report of a seven-year project (2004 through 2010) to evaluate the cumulative effects of habitat restoration actions in the lower Columbia River and estuary (LCRE). The project, called the Cumulative Effects Study, is being conducted for the U.S. Army Corps of Engineers Portland District (USACE) by the Marine Sciences Laboratory of the Pacific Northwest National Laboratory (PNNL), the Pt. Adams Biological Field Station of the National Marine Fisheries Service (NMFS), the Columbia River Estuary Study Taskforce (CREST), and the University of Washington. The goal of the Cumulative Effects Study is to develop a methodology to evaluate the cumulative effects of multiple habitat restoration projects intended to benefit ecosystems supporting juvenile salmonids in the 235-km-long LCRE. Literature review in 2004 revealed no existing methods for such an evaluation and suggested that cumulative effects could be additive or synergistic. From 2005 through 2009, annual field research involved intensive, comparative studies paired by habitat type (tidal swamp versus marsh), trajectory (restoration versus reference site), and restoration action (tidegate replacement vs. culvert replacement vs. dike breach).

Return to the river: strategies for salmon restoration in the Columbia River Basin.

Science.gov (United States)

Richard N. Williams; Jack A. Standford; James A. Lichatowich; William J. Liss; Charles C. Coutant; Willis E. McConnaha; Richard R. Whitney; Phillip R. Mundy; Peter A. Bisson; Madison S. Powell

2006-01-01

The Columbia River today is a great "organic machine" (White 1995) that dominates the economy of the Pacific Northwest. Even though natural attributes remain—for example, salmon production in Washington State's Hanford Reach, the only unimpounded reach of the mainstem Columbia River—the Columbia and Snake River mainstems are dominated...

Live cell imaging combined with high-energy single-ion microbeam

Science.gov (United States)

Guo, Na; Du, Guanghua; Liu, Wenjing; Guo, Jinlong; Wu, Ruqun; Chen, Hao; Wei, Junzhe

2016-03-01

DNA strand breaks can lead to cell carcinogenesis or cell death if not repaired rapidly and efficiently. An online live cell imaging system was established at the high energy microbeam facility at the Institute of Modern Physics to study early and fast cellular response to DNA damage after high linear energy transfer ion radiation. The HT1080 cells expressing XRCC1-RFP were irradiated with single high energy nickel ions, and time-lapse images of the irradiated cells were obtained online. The live cell imaging analysis shows that strand-break repair protein XRCC1 was recruited to the ion hit position within 20 s in the cells and formed bright foci in the cell nucleus. The fast recruitment of XRCC1 at the ion hits reached a maximum at about 200 s post-irradiation and then was followed by a slower release into the nucleoplasm. The measured dual-exponential kinetics of XRCC1 protein are consistent with the proposed consecutive reaction model, and the measurements obtained that the reaction rate constant of the XRCC1 recruitment to DNA strand break is 1.2 × 10-3 s-1 and the reaction rate constant of the XRCC1 release from the break-XRCC1 complex is 1.2 × 10-2 s-1.

Seasonal Juvenile Salmonid Presence and Migratory Behavior in the Lower Columbia River

Energy Technology Data Exchange (ETDEWEB)

Carter, Jessica A.; McMichael, Geoffrey A.; Welch, Ian D.; Harnish, Ryan A.; Bellgraph, Brian J.

2009-04-30

To facilitate preparing Biological Assessments of proposed channel maintenance projects, the Portland District of the U.S. Army Corps of Engineers contracted the Pacific Northwest National Laboratory to consolidate and synthesize available information about the use of the lower Columbia River and estuary by juvenile anadromous salmonids. The information to be synthesized included existing published documents as well as data from five years (2004-2008) of acoustic telemetry studies conducted in the Columbia River estuary using the Juvenile Salmon Acoustic Telemetry System. For this synthesis, the Columbia River estuary includes the section of the Columbia River from Bonneville Dam at river kilometer (Rkm) 235 downstream to the mouth where it enters the Pacific Ocean. In this report, we summarize the seasonal salmonid presence and migration patterns in the Columbia River estuary based on information from published studies as well as relevant data from acoustic telemetry studies conducted by NOAA Fisheries and the Pacific Northwest National Laboratory (PNNL) between 2004 and 2008. Recent acoustic telemetry studies, conducted using the Juvenile Salmon Acoustic Telemetry System (JSATS; developed by the Portland District of the U.S. Army Corps of Engineers), provided information on the migratory behavior of juvenile steelhead (O. mykiss) and Chinook salmon in the Columbia River from Bonneville Dam to the Pacific Ocean. In this report, Section 2 provides a summary of information from published literature on the seasonal presence and migratory behavior of juvenile salmonids in the Columbia River estuary and plume. Section 3 presents a detailed synthesis of juvenile Chinook salmon and steelhead migratory behavior based on use of the JSATS between 2004 and 2008. Section 4 provides a discussion of the information summarized in the report as well as information drawn from literature reviews on potential effects of channel maintenance activities to juvenile salmonids rearing in

BCASP and the Evolution of School Psychology in British Columbia

Science.gov (United States)

Agar, Douglas J.

2016-01-01

Since 1992, the British Columbia Association of School Psychologists (BCASP) has been the professional body for school psychologists in British Columbia. In the intervening 24 years, BCASP has been very successful in performing the dual roles of a certifying body and a professional development organization for school psychologists in British…

78 FR 15293 - Drawbridge Operation Regulations; Columbia River, Vancouver, WA

Science.gov (United States)

2013-03-11

... operating schedule that governs the Burlington Northern Santa Fe (BNSF) Railway Bridge across the Columbia... replacement of movable bridge joints. During these maintenance periods the swing span of the BNSF Railway... allows the swing span of the BNSF Railway Bridge across the Columbia River, mile 105.6, to remain in the...

Columbia River ESI: HABITATS (Habitat Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for submerged aquatic vegetation (SAV), rare plant species [Water howellia (Howelia aquatilis) and Columbia...

76 FR 6525 - Airworthiness Directives; Cessna Aircraft Company (Type Certificate Previously Held by Columbia...

Science.gov (United States)

2011-02-07

... Airworthiness Directives; Cessna Aircraft Company (Type Certificate Previously Held by Columbia Aircraft... following new AD: 2011-03-04 Cessna Aircraft Company (Type Certificate Previously Held by Columbia Aircraft... the following Cessna Aircraft Company (type certificate previously held by Columbia Aircraft...

The set-up for forward scattered particle detection at the external microbeam facility of the INFN-LABEC laboratory in Florence

International Nuclear Information System (INIS)

Giuntini, L.; Massi, M.; Calusi, S.; Gelli, N.; Castelli, L.; Carraresi, L.; Czelusniak, C.; Fedi, M.E.; Gueli, A.M.; Liccioli, L.; Mandò, P.A.; Mazzinghi, A.; Palla, L.

2015-01-01

In the last few years some new implementations and upgrades have been made to the external scanning microbeam of INFN-LABEC laboratory in Florence, enriching the existing PIXE, PIGE, BS, IBIL set-up with complementary techniques, when possible allowing for simultaneous multi-technique analyses. We developed a system, compatible with the existing set-up, for the out-of-vacuum detection of the forward scattered particles. This system makes feasible the external-STIM (Scanning Transmission Ion Microscopy) and external-FS (Forward Scattering), now both available at our beamline. Test measurements are shortly presented

Damaging and protective bystander cross-talk between human lung cancer and normal cells after proton microbeam irradiation

International Nuclear Information System (INIS)

Desai, Sejal; Kobayashi, Alisa; Konishi, Teruaki; Oikawa, Masakazu; Pandey, Badri N.

2014-01-01

Graphical abstract: - Highlights: • Proton-microbeam irradiated A549 cells send damaging signals to bystander A549 cells. • Irradiated A549–A549 bystander response is through gap junctional communication. • Bystander WI38 cells exert protective signalling in irradiated A549 cells. • Rescue of irradiated A549 cells by WI38 cells is independent of gap junctions. - Abstract: Most of the studies of radiation-induced bystander effects (RIBE) have been focused on understanding the radiobiological changes observed in bystander cells in response to the signals from irradiated cells in a normal cell population with implications to radiation risk assessment. However, reports on RIBE with relevance to cancer radiotherapy especially investigating the bidirectional and criss-cross bystander communications between cancer and normal cells are limited. Hence, in present study employing co-culture approach, we have investigated the bystander cross-talk between lung cancer (A549) and normal (WI38) cells after proton-microbeam irradiation using γ-H2AX foci fluorescence as a measure of DNA double-strand breaks (DSBs). We observed that in A549–A549 co-cultures, irradiated A549 cells exert damaging effects in bystander A549 cells, which were found to be mediated through gap junctional intercellular communication (GJIC). However, in A549–WI38 co-cultures, irradiated A549 did not affect bystander WI38 cells. Rather, bystander WI38 cells induced inverse protective signalling (rescue effect) in irradiated A549 cells, which was independent of GJIC. On the other hand, in response to irradiated WI38 cells neither of the bystander cells (A549 or WI38) showed significant increase in γ-H2AX foci. The observed bystander signalling between tumour and normal cells may have potential implications in therapeutic outcome of cancer radiotherapy

Damaging and protective bystander cross-talk between human lung cancer and normal cells after proton microbeam irradiation

Energy Technology Data Exchange (ETDEWEB)

Desai, Sejal [Radiation Signalling and Cancer Biology Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Kobayashi, Alisa; Konishi, Teruaki; Oikawa, Masakazu [Radiation System and Engineering Section, Department of Technical Support and Development, Research, Development and Support Center, National Institute of Radiological Sciences, Chiba 263-8555 (Japan); Pandey, Badri N., E-mail: badrinarain@yahoo.co.in [Radiation Signalling and Cancer Biology Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India)

2014-05-15

Graphical abstract: - Highlights: • Proton-microbeam irradiated A549 cells send damaging signals to bystander A549 cells. • Irradiated A549–A549 bystander response is through gap junctional communication. • Bystander WI38 cells exert protective signalling in irradiated A549 cells. • Rescue of irradiated A549 cells by WI38 cells is independent of gap junctions. - Abstract: Most of the studies of radiation-induced bystander effects (RIBE) have been focused on understanding the radiobiological changes observed in bystander cells in response to the signals from irradiated cells in a normal cell population with implications to radiation risk assessment. However, reports on RIBE with relevance to cancer radiotherapy especially investigating the bidirectional and criss-cross bystander communications between cancer and normal cells are limited. Hence, in present study employing co-culture approach, we have investigated the bystander cross-talk between lung cancer (A549) and normal (WI38) cells after proton-microbeam irradiation using γ-H2AX foci fluorescence as a measure of DNA double-strand breaks (DSBs). We observed that in A549–A549 co-cultures, irradiated A549 cells exert damaging effects in bystander A549 cells, which were found to be mediated through gap junctional intercellular communication (GJIC). However, in A549–WI38 co-cultures, irradiated A549 did not affect bystander WI38 cells. Rather, bystander WI38 cells induced inverse protective signalling (rescue effect) in irradiated A549 cells, which was independent of GJIC. On the other hand, in response to irradiated WI38 cells neither of the bystander cells (A549 or WI38) showed significant increase in γ-H2AX foci. The observed bystander signalling between tumour and normal cells may have potential implications in therapeutic outcome of cancer radiotherapy.

Supercritical nonlinear parametric dynamics of Timoshenko microbeams

Science.gov (United States)

Farokhi, Hamed; Ghayesh, Mergen H.

2018-06-01

The nonlinear supercritical parametric dynamics of a Timoshenko microbeam subject to an axial harmonic excitation force is examined theoretically, by means of different numerical techniques, and employing a high-dimensional analysis. The time-variant axial load is assumed to consist of a mean value along with harmonic fluctuations. In terms of modelling, a continuous expression for the elastic potential energy of the system is developed based on the modified couple stress theory, taking into account small-size effects; the kinetic energy of the system is also modelled as a continuous function of the displacement field. Hamilton's principle is employed to balance the energies and to obtain the continuous model of the system. Employing the Galerkin scheme along with an assumed-mode technique, the energy terms are reduced, yielding a second-order reduced-order model with finite number of degrees of freedom. A transformation is carried out to convert the second-order reduced-order model into a double-dimensional first order one. A bifurcation analysis is performed for the system in the absence of the axial load fluctuations. Moreover, a mean value for the axial load is selected in the supercritical range, and the principal parametric resonant response, due to the time-variant component of the axial load, is obtained - as opposed to transversely excited systems, for parametrically excited system (such as our problem here), the nonlinear resonance occurs in the vicinity of twice any natural frequency of the linear system; this is accomplished via use of the pseudo-arclength continuation technique, a direct time integration, an eigenvalue analysis, and the Floquet theory for stability. The natural frequencies of the system prior to and beyond buckling are also determined. Moreover, the effect of different system parameters on the nonlinear supercritical parametric dynamics of the system is analysed, with special consideration to the effect of the length-scale parameter.

'BioQuaRT' project: design of a novel in situ protocol for the simultaneous visualisation of chromosomal aberrations and micronuclei after irradiation at microbeam facilities

International Nuclear Information System (INIS)

Patrono, C.; Testa, A.; Monteiro Gil, O.; Giesen, U.; Langner, F.; Rabus, H.; Pinto, M.

2015-01-01

The aim of the 'BioQuaRT' (Biologically weighted Quantities in Radiotherapy) project is to develop measurement techniques for characterising charged particle track structure on different length scales, and to correlate at the cellular level the track structure properties with the biological effects of radiation. This multi-scale approach will allow characterisation of the radiation qualities used in radiotherapy and the related biological effects. Charged-particle microbeam facilities were chosen as the platforms for all radiobiology experiments in the 'BioQuaRT' project, because they allow targeting single cells (or compartments of a cell) with a predefined number of ionising particles and correlating the cell-by-cell induced damage with type and energy of the radiation and with the number of ions per cell. Within this project, a novel in situ protocol was developed for the analysis of the mis-repaired and/or unrepaired chromosome damage induced by charged-particle irradiations at the Physikalisch-Technische Bundesanstalt (PTB) ion microbeam facility. Among the cytogenetic biomarkers to detect and estimate radiation-induced DNA damage in radiobiology, chromosomal aberrations and micronuclei were chosen. The characteristics of the PTB irradiation system required the design of a special in situ assay: specific irradiation dishes with a base made from a bio-foil 25-μm thick and only 3000-4000 cells seeded and irradiated per dish. This method was developed on Chinese hamster ovary (CHO) cells, one of the most commonly used cell lines in radiobiology in vitro experiments. The present protocol allows the simultaneous scoring of chromosome aberrations and micronuclei on the same irradiated dish. Thanks to its versatility, this method could also be extended to other radiobiological applications besides the single-ion microbeam irradiations. (authors)

Columbia River ESI: FISH (Fish Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for marine, estuarine, anadromous, and freshwater fish species in Columbia River. Vector polygons in this...

LabVIEW control software for scanning micro-beam X-ray fluorescence spectrometer.

Science.gov (United States)

Wrobel, Pawel; Czyzycki, Mateusz; Furman, Leszek; Kolasinski, Krzysztof; Lankosz, Marek; Mrenca, Alina; Samek, Lucyna; Wegrzynek, Dariusz

2012-05-15

Confocal micro-beam X-ray fluorescence microscope was constructed. The system was assembled from commercially available components - a low power X-ray tube source, polycapillary X-ray optics and silicon drift detector - controlled by an in-house developed LabVIEW software. A video camera coupled to optical microscope was utilized to display the area excited by X-ray beam. The camera image calibration and scan area definition software were also based entirely on LabVIEW code. Presently, the main area of application of the newly constructed spectrometer is 2-dimensional mapping of element distribution in environmental, biological and geological samples with micrometer spatial resolution. The hardware and the developed software can already handle volumetric 3-D confocal scans. In this work, a front panel graphical user interface as well as communication protocols between hardware components were described. Two applications of the spectrometer, to homogeneity testing of titanium layers and to imaging of various types of grains in air particulate matter collected on membrane filters, were presented. Copyright © 2012 Elsevier B.V. All rights reserved.

Investigation of the Dynamics of a Clamped-Clamped Microbeam Near the Third Mode Using a Partial Electrode

KAUST Repository

Masri, Karim M.

2014-08-17

We present an investigation of the dynamics of a clamped-clamped microbeam excited electrostatically near its third mode. To maximize the response at the third mode, a partial electrode configuration is utilized. A multi-mode Galerkin method is used to develop a reduced order model (ROM) of the beam. A shooting method to find the periodic motion is utilized to generate frequency response curves. The curves show hardenining behavior and dynamic pull-in. We show that the dynamic amplitude of the partial configuration is higher than that of a full electrode configuration. These results are promising for the use of higher-order modes for mass detection and for ultra sensitive resonant sensors.

Wide-range frequency selectivity in an acoustic sensor fabricated using a microbeam array with non-uniform thickness

International Nuclear Information System (INIS)

Shintaku, Hirofumi; Kotera, Hidetoshi; Kobayashi, Takayuki; Zusho, Kazuki; Kawano, Satoyuki

2013-01-01

In this study, we have demonstrated the fabrication of a microbeam array (MBA) with various thicknesses and investigated the suitability it for an acoustic sensor with wide-range frequency selectivity. For this, an MBA composed of 64 beams, with thicknesses varying from 2.99–142 µm, was fabricated by using single gray-scale lithography and a thick negative photoresist. The vibration of the beams in air was measured using a laser Doppler vibrometer; the resonant frequencies of the beams were measured to be from 11.5 to 290 kHz. Lastly, the frequency range of the MBA with non-uniform thickness was 10.9 times that of the MBA with uniform thickness. (paper)

Investigation of the Dynamics of a Clamped-Clamped Microbeam Near the Third Mode Using a Partial Electrode

KAUST Repository

Masri, Karim M.; Younis, Mohammad I.

2014-01-01

We present an investigation of the dynamics of a clamped-clamped microbeam excited electrostatically near its third mode. To maximize the response at the third mode, a partial electrode configuration is utilized. A multi-mode Galerkin method is used to develop a reduced order model (ROM) of the beam. A shooting method to find the periodic motion is utilized to generate frequency response curves. The curves show hardenining behavior and dynamic pull-in. We show that the dynamic amplitude of the partial configuration is higher than that of a full electrode configuration. These results are promising for the use of higher-order modes for mass detection and for ultra sensitive resonant sensors.

Columbia River ESI: INVERT (Invertebrate Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for clams, oysters, crabs, and other invertebrate species in Columbia River. Vector polygons in this data...

Columbia River ESI: FISHL (Fish Lines)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for anadromous fish species in Columbia River. Vector lines in this data set represent locations of...

11 CFR 108.8 - Exemption for the District of Columbia.

Science.gov (United States)

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Exemption for the District of Columbia. 108.8 Section 108.8 Federal Elections FEDERAL ELECTION COMMISSION GENERAL FILING COPIES OF REPORTS AND STATEMENTS WITH STATE OFFICERS (2 U.S.C. 439) § 108.8 Exemption for the District of Columbia. Any copy of a...

The use of the foil technique for the elimination of charging, and for beam monitoring in microbeam analysis of thick insulating samples

International Nuclear Information System (INIS)

Chaudhri, M.A.; Melbourne Univ., Austin

1982-01-01

It has been demonstrated that the 'thin-foil-technique' for the elimination of charging and accurate beam current/charge measurement, first developed by us, can also be conveniently applied to microbeam analysis of thick insulating samples. We have calculated the spatial broadening of proton microbeams of 1-20 MeV energies at the target, due to thin carbon foils of different thicknesses ranging from 10-40 μg/cm 2 placed either 2 or 5 mm in front of the target by using Moliere's theory of multiple scattering. The results show that at higher proton energies there is very little broadening of the incident beam even from thicker foils. But for lower energy protons (1 and 2 MeV) this broadening or worsening of the spatial resolution is relatively larger, especially from thicker foils. However, we have further shown that, even at these energies, the beam broadening can be minimized to acceptable limits by selecting a suitable thickness of carbon foil and placing it as close to the insulating target as possible. A comprehensive table is provided, which would help in selecting the most suitable carbon-foil thickness and the distance in front of the target where this foil should be placed, for microprobe application requiring different beam spots and proton energies. The advantages of this foil technique are described. (orig.)

Additions and corrections to the bibliography of geologic studies, Columbia Plateau (Columbia River Besalt) and adjacent Areas, in Idaho, 1980

International Nuclear Information System (INIS)

Strowd, W.

1980-01-01

This bibliography is an update to Idaho Bureau of Mines and Geology Open-File Report 78-6, Bibliography of Geological Studies, Columbia Plateau (Columbia River Basalt Group) and adjacent areas in Idaho (also known as Rockwell Hanford Operations' contractor report RHO-BWI-C-44). To keep the original document current, this additions and corrections report was prepared for the Basalt Waste Isolation Project of Rockwell Hanford Operations. This update is supplementary; therefore, references cited in the original document have not been included here. What is included are materials that have become available since the original publication and pertinent literature that had originally been overlooked. Accompany this updated bubliography are index maps that show locations of geologic studies and geochemical petrographic, remanent paleomagnetic, and radiometric age-dated sites within the Columbia River Basalt Group field within Idaho; also identified are archeological sites, test wells, mines, quarries, and other types of excavations. References on the index maps are keyed to the bibliography and cover the Spokane, Pullman, Hamilton, Grangeville, Elk City, Baker, Boise, and Jordan Valley Army Map Service two-degree quadrangles

Targeted heavy-ion microbeam irradiation of the embryo but not yolk in the diapause-terminated egg of the silkworm, bombyx mori, induces the somatic mutation

International Nuclear Information System (INIS)

Furusawa, Toshiharu; Fukamoto, Kana; Sakashita, Tetsuya; Funayama, Tomoo; Kobayashi, Yasuhiko; Kakizaki, Takehiko; Wada, Seiichi; Hamada, Nobuyuki; Suzuki, Hiromi; Ishioka, Noriaki; Nagaoka, Shunji

2009-01-01

Using heavy-ion microbeam, we report target irradiation of selected compartments within the diapause-terminated egg and its mutational consequences in the silkworm, Bombyx mori. On one hand, carbon-ion exposure of embryo to 0.5-6 Gy increased the somatic mutation frequency, suggesting targeted radiation effects. On the other, such increases were not observed when yolk was targeted, suggesting a lack of nontargeted bystander effect. (author)

Columbia River ESI: NESTS (Nest Points)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for bird nesting sites in the Columbia River area. Vector points in this data set represent locations of...

Evaluation of dose-volume metrics for microbeam radiation therapy dose distributions in head phantoms of various sizes using Monte Carlo simulations

Science.gov (United States)

Anderson, Danielle; Siegbahn, E. Albert; Fallone, B. Gino; Serduc, Raphael; Warkentin, Brad

2012-05-01

This work evaluates four dose-volume metrics applied to microbeam radiation therapy (MRT) using simulated dosimetric data as input. We seek to improve upon the most frequently used MRT metric, the peak-to-valley dose ratio (PVDR), by analyzing MRT dose distributions from a more volumetric perspective. Monte Carlo simulations were used to calculate dose distributions in three cubic head phantoms: a 2 cm mouse head, an 8 cm cat head and a 16 cm dog head. The dose distribution was calculated for a 4 × 4 mm2 microbeam array in each phantom, as well as a 16 × 16 mm2 array in the 8 cm cat head, and a 32 × 32 mm2 array in the 16 cm dog head. Microbeam widths of 25, 50 and 75 µm and center-to-center spacings of 100, 200 and 400 µm were considered. The metrics calculated for each simulation were the conventional PVDR, the peak-to-mean valley dose ratio (PMVDR), the mean dose and the percentage volume below a threshold dose. The PVDR ranged between 3 and 230 for the 2 cm mouse phantom, and between 2 and 186 for the 16 cm dog phantom depending on geometry. The corresponding ranges for the PMVDR were much smaller, being 2-49 (mouse) and 2-46 (dog), and showed a slightly weaker dependence on phantom size and array size. The ratio of the PMVDR to the PVDR varied from 0.21 to 0.79 for the different collimation configurations, indicating a difference between the geometric dependence on outcome that would be predicted by these two metrics. For unidirectional irradiation, the mean lesion dose was 102%, 79% and 42% of the mean skin dose for the 2 cm mouse, 8 cm cat and 16 cm dog head phantoms, respectively. However, the mean lesion dose recovered to 83% of the mean skin dose in the 16 cm dog phantom in intersecting cross-firing regions. The percentage volume below a 10% dose threshold was highly dependent on geometry, with ranges for the different collimation configurations of 2-87% and 33-96% for the 2 cm mouse and 16 cm dog heads, respectively. The results of this study

Evaluation of dose-volume metrics for microbeam radiation therapy dose distributions in head phantoms of various sizes using Monte Carlo simulations

International Nuclear Information System (INIS)

Anderson, Danielle; Fallone, B Gino; Warkentin, Brad; Siegbahn, E Albert; Serduc, Raphael

2012-01-01

This work evaluates four dose-volume metrics applied to microbeam radiation therapy (MRT) using simulated dosimetric data as input. We seek to improve upon the most frequently used MRT metric, the peak-to-valley dose ratio (PVDR), by analyzing MRT dose distributions from a more volumetric perspective. Monte Carlo simulations were used to calculate dose distributions in three cubic head phantoms: a 2 cm mouse head, an 8 cm cat head and a 16 cm dog head. The dose distribution was calculated for a 4 × 4 mm 2 microbeam array in each phantom, as well as a 16 × 16 mm 2 array in the 8 cm cat head, and a 32 × 32 mm 2 array in the 16 cm dog head. Microbeam widths of 25, 50 and 75 µm and center-to-center spacings of 100, 200 and 400 µm were considered. The metrics calculated for each simulation were the conventional PVDR, the peak-to-mean valley dose ratio (PMVDR), the mean dose and the percentage volume below a threshold dose. The PVDR ranged between 3 and 230 for the 2 cm mouse phantom, and between 2 and 186 for the 16 cm dog phantom depending on geometry. The corresponding ranges for the PMVDR were much smaller, being 2–49 (mouse) and 2–46 (dog), and showed a slightly weaker dependence on phantom size and array size. The ratio of the PMVDR to the PVDR varied from 0.21 to 0.79 for the different collimation configurations, indicating a difference between the geometric dependence on outcome that would be predicted by these two metrics. For unidirectional irradiation, the mean lesion dose was 102%, 79% and 42% of the mean skin dose for the 2 cm mouse, 8 cm cat and 16 cm dog head phantoms, respectively. However, the mean lesion dose recovered to 83% of the mean skin dose in the 16 cm dog phantom in intersecting cross-firing regions. The percentage volume below a 10% dose threshold was highly dependent on geometry, with ranges for the different collimation configurations of 2–87% and 33–96% for the 2 cm mouse and 16 cm dog heads, respectively. The results of this

MHD simulation of Columbia HBT

International Nuclear Information System (INIS)

Li, X.L.

1987-01-01

The plasma of Columbia High Beta Tokamak (HBT) is studied numerically by using the two dimensional resistive MHD model. The main object of this work is to understand the high beta formation process of HBT plasma and to compare the simulation with the experiments. 21 refs., 48 figs., 2 tabs

In situ biological dose mapping estimates the radiation burden delivered to 'spared' tissue between synchrotron X-ray microbeam radiotherapy tracks.

Directory of Open Access Journals (Sweden)

Kai Rothkamm

Full Text Available Microbeam radiation therapy (MRT using high doses of synchrotron X-rays can destroy tumours in animal models whilst causing little damage to normal tissues. Determining the spatial distribution of radiation doses delivered during MRT at a microscopic scale is a major challenge. Film and semiconductor dosimetry as well as Monte Carlo methods struggle to provide accurate estimates of dose profiles and peak-to-valley dose ratios at the position of the targeted and traversed tissues whose biological responses determine treatment outcome. The purpose of this study was to utilise γ-H2AX immunostaining as a biodosimetric tool that enables in situ biological dose mapping within an irradiated tissue to provide direct biological evidence for the scale of the radiation burden to 'spared' tissue regions between MRT tracks. Γ-H2AX analysis allowed microbeams to be traced and DNA damage foci to be quantified in valleys between beams following MRT treatment of fibroblast cultures and murine skin where foci yields per unit dose were approximately five-fold lower than in fibroblast cultures. Foci levels in cells located in valleys were compared with calibration curves using known broadbeam synchrotron X-ray doses to generate spatial dose profiles and calculate peak-to-valley dose ratios of 30-40 for cell cultures and approximately 60 for murine skin, consistent with the range obtained with conventional dosimetry methods. This biological dose mapping approach could find several applications both in optimising MRT or other radiotherapeutic treatments and in estimating localised doses following accidental radiation exposure using skin punch biopsies.

Columbia River system operation review. Final environmental impact statement

International Nuclear Information System (INIS)

1995-11-01

This Appendix C of the Final Environmental Impact Statement for the Columbia River System discusses impacts on andromous fish and juvenile fish transportation. The principal andromous fish in the Columbia basin include salmonid species (Chinook, coho, and sockeye salmon, and steelhead) and nonsalmoinid andromous species (sturgeon, lamprey, and shad). Major sections in this document include the following: background, scope and process; affected environment for salmon and steelhead, shaded, lamprey, sturgeon; study methods; description of alternatives: qualitative and quantitative findings

76 FR 64959 - District of Columbia; Major Disaster and Related Determinations

Science.gov (United States)

2011-10-19

... of Columbia resulting from Hurricane Irene during the period of August 26 to September 1, 2011, is of... following areas of the District of Columbia have been designated as adversely affected by this major... Unemployment Assistance (DUA); 97.046, Fire Management Assistance Grant; 97.048, Disaster Housing Assistance to...

Columbia River system operation review. Final environmental impact statement

International Nuclear Information System (INIS)

1995-11-01

The Columbia River and its tributaries are the primary water system in the Pacific Northwest, draining some 219,000 square miles in seven states and another 39,500 square miles in British Columbia. Beginning in the 1930's, the Columbia River has been significantly modified by construction of 30 major dams on the river and its tributaries, along with dozens of non-Federal projects. Construction and subsequent operation of these water development projects have contributed to eight primary uses of the river system, including navigation, flood control, irrigation, electric power generation, fish migration, fish and wildlife habitat, recreation, and water supply and quality considerations. Increasing stress on the water development of the Columbia River and its tributaries has led primary Federal agencies to undertake intensive analysis and evaluation of the operation of these projects. These agencies are the U.S. Army Corps of Engineers and the Bureau of Reclamation, who operate the large Federal dams on the river, and the Bonneville Power Administration who sells the power generated at the dams. This review, termed the System Operation Review (SOR), has as its ultimate goal to define a strategy for future operation of the major Columbia River projects which effectively considers the needs of all river uses. This volume, Appendix D: Cultural resources appendix, Technical imput includes the following: Development of geomorphology based framework for cultural resources management, Dworshak Reservoir, Idaho; Impact profiles for SOR reservoirs; comments from the following Native American tribes: Burns Paiute Tribe; Coville Confederated Tribes; Confederated Tribes of the Warm Springs Indian Reservation; Confederated Tribes and bands of the Yakama Indian Nation (comments); Nez Perce Tribe; Coeur D'Alene Tribe; Spokane Tribe of Indians; The confederated Tribes of the Umatilla Indian Reservation

British Columbia natural gas: Core market policy

International Nuclear Information System (INIS)

1988-06-01

The core market for natural gas in British Columbia is defined as all natural gas consumers in the residential, institutional, commercial, and industrial sectors not currently purchasing natural gas directly and not exempted from the core market by the British Columbia Utilities Commission (BCUC). The intent of the definition is to include all customers who must be protected by contracts which ensure long-term security of supply and stable prices. Core market customers are excluded from direct natural gas purchase and will be served by distribution utilities. A customer may apply to BCUC to leave the core market; such an application may be approved if it is demonstrated that the customer has adequate long-term natural gas supplies or alternative fuel supplies to protect him from supply interruptions. The non-core market is defined as all large industrial customers who elect to make their own natural gas supply arrangements and who can demonstrate to the BCUC sufficient long-term natural gas supply protection or alternative fuel capability to ensure security of the industry. Non-core market customers have full and open access to the competitive natural gas market. The British Columbia government will not apply its core market policy to other jurisdictions through Energy Removal Certificates

Investigation on the biological effects of pharynx irradiation by single-particle microbeam and C.elegans immobilization

International Nuclear Information System (INIS)

Guo Xiaoying; Yang Gen; Chen Lianyun; Wu Lijun; Li Buqing

2010-01-01

Using C.elegans- with clear genetic background, easy genetic maneuverability, small individual, transparence, easily penetrated by a variety of particle as a in vivo model organism, irradiation damage at the individual level of the signal transduction and the mechanism research were investigated. In order to radiate accurately, the worms need Immobilize. The results showed that the ether: ethanol = 1:1 mixture, enabled the worms quickly anesthesia, and kept the worms Immobilization in the whole irradiation process, then quickly recovered after irradiation and recovery rate of 100%. On the basis, the laved and the apoptotic cells in the distal gonad would be test when the worm pharynx were irradiated by single-particle microbeam. The primary results showed that the apoptotic cells in distal gonad significantly increased when the worm pharynx were irradiated 5000 particles. (authors)

Identification of contaminants of concern Columbia River Comprehensive Impact Assessment

International Nuclear Information System (INIS)

Napier, B.A.; Batishko, N.C.; Heise-Craff, D.A.; Jarvis, M.F.; Snyder, S.F.

1995-01-01

The Columbia River Comprehensive Impact Assessment (CRCIA) Project at the Pacific Northwest Laboratory (PNL) is evaluating the current human and ecological risks from contaminants in the Columbia River. The risks to be studied are those attributable to past and present activities on the Hanford Site. The Hanford Site is located in southcentral Washington State near the town of Richland. Human risk from exposure to radioactive and hazardous materials will be addressed for a range of river use options. Ecological risk will be evaluated relative to the health of the current river ecosystem. The overall purpose of the project is to determine if enough contamination exists in the Columbia River to warrant cleanup actions under applicable environmental regulations. This report documents an initial review, from a risk perspective, of the wealth of historical data concerning current or potential contamination in the Columbia River. Sampling data were examined for over 600 contaminants. A screening analysis was performed to identify those substances present in such quantities that they may pose a significant human or ecological risk. These substances will require a more detailed analysis to assess their impact on humans or the river ecosystem

Comparative measurement of silicon and major elements (P,S,Cl,K,Ca) in arterial walls using macro and microbeam analysis

International Nuclear Information System (INIS)

Moretto, P.

1987-01-01

There are few techniques available for the measurement of silicon at trace levels in biological materials. PIXE and prompt nuclear reaction analysis were used to locate and measure silicon and major elements in arterial walls. Macrobeam analysis, carried out by the Van de Graaff accelerator at CENBG, enabled measurement of mean tissue levels. Microbeam analysis, using the nuclear microprobe at Karlsruhe, yielded the distribution of these elements through the thickness of the arterial wall. The microanalyses were performed on arterial walls from healthy rabbits and the macrobeam study was carried out on the same samples and also on human aorta specimens [fr

MPH Education for the 21st Century: Design of Columbia University’s New Public Health Curriculum

Science.gov (United States)

Galea, Sandro; Bayer, Ronald; Walker, Julia R.; Fried, Linda P.

2014-01-01

Because public health challenges are changing rapidly, over the past 3 years, we have turned a critical eye to the master of public health program at the Columbia University Mailman School of Public Health. Under a process dubbed “curriculum renewal,” we engaged more than 170 faculty, staff, and students (and hundreds of alumni and employers of our graduates) in an initiative to develop a completely new design for master of public health education that launched in fall 2012. We have described its design and structure and presented some preliminary evaluation data. PMID:24228682

Live cell imaging combined with high-energy single-ion microbeam

Energy Technology Data Exchange (ETDEWEB)

Guo, Na; Du, Guanghua, E-mail: gh-du@impcas.ac.cn; Liu, Wenjing; Wu, Ruqun; Wei, Junzhe [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou (China); Guo, Jinlong [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou (China); Northwest Normal University, Lanzhou (China); Chen, Hao [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou (China); Institute of Nuclear Science and Technology, University of Lanzhou, Lanzhou (China)

2016-03-15

DNA strand breaks can lead to cell carcinogenesis or cell death if not repaired rapidly and efficiently. An online live cell imaging system was established at the high energy microbeam facility at the Institute of Modern Physics to study early and fast cellular response to DNA damage after high linear energy transfer ion radiation. The HT1080 cells expressing XRCC1-RFP were irradiated with single high energy nickel ions, and time-lapse images of the irradiated cells were obtained online. The live cell imaging analysis shows that strand-break repair protein XRCC1 was recruited to the ion hit position within 20 s in the cells and formed bright foci in the cell nucleus. The fast recruitment of XRCC1 at the ion hits reached a maximum at about 200 s post-irradiation and then was followed by a slower release into the nucleoplasm. The measured dual-exponential kinetics of XRCC1 protein are consistent with the proposed consecutive reaction model, and the measurements obtained that the reaction rate constant of the XRCC1 recruitment to DNA strand break is 1.2 × 10{sup −3} s{sup −1} and the reaction rate constant of the XRCC1 release from the break-XRCC1 complex is 1.2 × 10{sup −2} s{sup −1}.

Live cell imaging combined with high-energy single-ion microbeam

International Nuclear Information System (INIS)

Guo, Na; Du, Guanghua; Liu, Wenjing; Wu, Ruqun; Wei, Junzhe; Guo, Jinlong; Chen, Hao

2016-01-01

DNA strand breaks can lead to cell carcinogenesis or cell death if not repaired rapidly and efficiently. An online live cell imaging system was established at the high energy microbeam facility at the Institute of Modern Physics to study early and fast cellular response to DNA damage after high linear energy transfer ion radiation. The HT1080 cells expressing XRCC1-RFP were irradiated with single high energy nickel ions, and time-lapse images of the irradiated cells were obtained online. The live cell imaging analysis shows that strand-break repair protein XRCC1 was recruited to the ion hit position within 20 s in the cells and formed bright foci in the cell nucleus. The fast recruitment of XRCC1 at the ion hits reached a maximum at about 200 s post-irradiation and then was followed by a slower release into the nucleoplasm. The measured dual-exponential kinetics of XRCC1 protein are consistent with the proposed consecutive reaction model, and the measurements obtained that the reaction rate constant of the XRCC1 recruitment to DNA strand break is 1.2 × 10"−"3 s"−"1 and the reaction rate constant of the XRCC1 release from the break-XRCC1 complex is 1.2 × 10"−"2 s"−"1.

Evaluation of support loss in micro-beam resonators: A revisit

Science.gov (United States)

Chen, S. Y.; Liu, J. Z.; Guo, F. L.

2017-12-01

This paper presents an analytical study on evaluation of support loss in micromechanical resonators undergoing in-plane flexural vibrations. Two-dimensional elastic wave theory is used to determine the energy transmission from the vibrating resonator to the support. Fourier transform and Green's function technique are adopted to solve the problem of wave motions on the surface of the support excited by the forces transmitted by the resonator onto the support. Analytical expressions of support loss in terms of quality factor, taking into account distributed normal stress and shear stress in the attachment region, and coupling between the normal stress and shear stress as well as material disparity between the support and the resonator, have been derived. Effects of geometry of micro-beam resonators, and material dissimilarity between support and resonator on support loss are examined. Numerical results show that 'harder resonator' and 'softer support' combination leads to larger support loss. In addition, the Perfectly Matched Layer (PML) numerical simulation technique is employed for validation of the proposed analytical model. Comparing with results of quality factor obtained by PML technique, we find that the present model agrees well with the results of PML technique and the pure-shear model overestimates support loss noticeably, especially for resonators with small aspect ratio and large material dissimilarity between the support and resonator.

Development over 25 years of Douglas-fir, western hemlock, and western redcedar planted at various spacings on a very good site in British Columbia.

Science.gov (United States)

Donald L. Reukema; J. Harry G. Smith

1987-01-01

Results of five spacing trials on the University of British Columbia Research Forest, covering a range of plantation spacings from 1 to 5 meters, showed that choice of initial spacing is among the most important factors influencing bole and crown development and stand growth and yield. The trials include Douglas-fir (Pseudotsuga menziesi), western...

Computer Simulation Performed for Columbia Project Cooling System

Science.gov (United States)

Ahmad, Jasim

2005-01-01

This demo shows a high-fidelity simulation of the air flow in the main computer room housing the Columbia (10,024 intel titanium processors) system. The simulation asseses the performance of the cooling system and identified deficiencies, and recommended modifications to eliminate them. It used two in house software packages on NAS supercomputers: Chimera Grid tools to generate a geometric model of the computer room, OVERFLOW-2 code for fluid and thermal simulation. This state-of-the-art technology can be easily extended to provide a general capability for air flow analyses on any modern computer room. Columbia_CFD_black.tiff

33 CFR 165.1316 - Safety Zone; Columbia River, Astoria, Oregon.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone; Columbia River....1316 Safety Zone; Columbia River, Astoria, Oregon. (a) Location. The following area is a safety zone... Oregon shoreline at 123°49′36″ West to 46°11′51″ North thence east to 123°48′53″ West thence south to the...

Columbia River system operation review. Final environmental impact statement

International Nuclear Information System (INIS)

1995-11-01

Since the 1930's, the Columbia River has been harnessed for the benefit of the Northwest and the nation. Federal agencies have built 30 major dams on the river and its tributaries. Dozens of non-Federal projects have been developed as well. The dams provide flood control, irrigation, navigation, hydro-electric power generation, recreation, fish and wildlife, and streamflows for wildlife, anadromous fish, resident fish, and water quality. This is Appendix F of the Environmental Impact Statement for the Columbia River System, focusing on irrigation issues and concerns arrising from the Irrigation and Mitigation of impacts (M ampersand I) working Group of the SOR process. Major subheadings include the following: Scope and process of irrigation/M ampersand I studies; Irrigation/M ampersand I in the Columbia Basin Today including overview, irrigated acreage and water rights, Irrigation and M ampersand I issues basin-wide and at specific locations; and the analysis of impacts and alternative for the Environmental Impact Statement

1992 Columbia River salmon flow measures Options Analysis/EIS

International Nuclear Information System (INIS)

1992-01-01

This Options Analysis/Environmental Impact Statement (OA/EIS) identifies, presents effects of, and evaluates the potential options for changing instream flow levels in efforts to increase salmon populations in the lower Columbia and Snake rivers. The potential actions would be implemented during 1992 to benefit juvenile and adult salmon during migration through eight run-of-river reservoirs. The Corps of Engineers (Corps) prepared this document in cooperation with the Bonneville Power Administration and the Bureau of Reclamation. The US Fish and Wildlife Service (FSWS) is a participating agency. The text and appendices of the document describe the characteristics of 10 Federal projects and one private water development project in the Columbia River drainage basin. Present and potential operation of these projects and their effects on the salmon that spawn and rear in the Columbia and Snake River System are presented. The life history, status, and response of Pacific salmon to current environmental conditions are described

1992 Columbia River Salmon Flow Measures Options Analysis/EIS.

Energy Technology Data Exchange (ETDEWEB)

1992-01-01

This Options Analysis/Environmental Impact Statement (OA/EIS) identifies, presents effects of, and evaluates the potential options for changing instream flow levels in efforts to increase salmon populations in the lower Columbia and Snake rivers. The potential actions would be implemented during 1992 to benefit juvenile and adult salmon during migration through eight run-of-river reservoirs. The Corps of Engineers (Corps) prepared this document in cooperation with the Bonneville Power Administration and the Bureau of Reclamation. The US Fish and Wildlife Service (FSWS) is a participating agency. The text and appendices of the document describe the characteristics of 10 Federal projects and one private water development project in the Columbia River drainage basin. Present and potential operation of these projects and their effects on the salmon that spawn and rear in the Columbia and Snake River System are presented. The life history, status, and response of Pacific salmon to current environmental conditions are described.

Surface hydrologic investigations of the Columbia Plateau Region, Washington

International Nuclear Information System (INIS)

Leonhart, L.S.

1979-07-01

The Washington State portion of the Columbia Plateau is divided into six hydrologic sub-basins on the basis of the principal surface drainage systems present, structural and topographic relationships, and political and other considerations. Baseline descriptions of the surface water systems and resources are presented for the Columbia Plateau with emphasis on the Pasco Sub-basin. A preliminary evaluation of the hydrologic budget for each sub-basin is derived. For each sub-basin, recharge/discharge relationships arising from precipitation/evapotranspiration/runoff, stream losses and gains, and artificial mechanisms are determined on the basis of available data. The net exchange between surface and groundwater systems is evaluated and relative estimates of the net groundwater flow into or out of the sub-basin are obtained. An evaluation is made of hydrologic risk factors arising from: (1) tributary flooding in eastern Washington; and, (2) major flooding of the Columbia River within the Pasco Sub-basin. Scenarios are presented for credible natural and man-generated catastrophic events

Did you know? Petroleum industry fast facts: British Columbia

International Nuclear Information System (INIS)

1999-10-01

This is part of a series of brochures published by the Petroleum Communication Foundation, a non-profit society established in 1975. The foundation's objective is to stimulate public awareness and understanding of Canada's petroleum industry and its contribution to the economy of each of the provinces where the industry's presence and impact is substantial. This brochure provides brief, but useful, information about British Columbia, about its area (947,800 sq.km), capital (Victoria), population (4.009,922 in 1998), major industries (forestry, wood and paper, petroleum and mining, tourism, agriculture, fishing, manufacturing), revenue from natural resources ($ 350 million from oil and natural gas in 1998-1999, or about 20 per cent of total provincial government revenues), some facts about the petroleum industry in British Columbia, (production, employment, pipelines, etc.), major exports (wood products, pulp and paper products, machinery and equipment, coal, petroleum products, electricity) and upstream industry expenditures in British Columbia (in excess of $ 1 billion). map, pie-chart, figs

Surface hydrologic investigations of the Columbia Plateau region, Washington

International Nuclear Information System (INIS)

Leonhart, L.S.

1979-01-01

The Washington State portion of the Columbia Plateau is divided into six hydrologic sub-basins on the basis of the principal surface drainage systems present, structural and topographic relationships, and political and other considerations. Baseline descriptions of the surface water systems and resources are presented for the Columbia Plateau with emphasis on the Pasco Sub-basin. A preliminary evaluation of the hydrologic budget for each sub-basin is derived. For each sub-basin, recharge/discharge relationships arising from precipitation/evapotranspiration/runoff, stream losses and gains, and artificial mechanisms are determined on the basis of available data. The net exchange between surface and ground-water systems is evaluated and relative estimates of the net ground-water flow into or out of the sub-basin are obtained. An evaluation is made of hydrologic risk factors arising from: (1) tributary flooding in eastern Washington; and (2) major flooding of the Columbia River within the Pasco Sub-basin. Scenarios are presented for credible natural and man-generated catastrophic events

A Microbeam Resonator with Partial Electrodes for Logic and Memory Elements

KAUST Repository

Hafiz, Md Abdullah Al

2017-11-10

We demonstrate logic and memory elements based on an in-plane clamped-clamped microbeam resonator. The micro-resonator is electrostatically actuated through a drive electrode and the motional signal is capacitively sensed at a sense electrode, while the resonance characteristics are modulated by DC voltage pulses provided at two separate partial electrodes, independent of the drive/sense electrodes. For the logic applications, we use two separate electrodes to provide DC voltages defined as the logic inputs. The high (low) motional signal at on-resonance (off-resonance) state is defined as the logic output state “1” (“0”). For the memory operation, two stable vibrational states, high and low, within the hysteretic regime are defined as the memory states, “1” and “0”, respectively. We take advantage of the split electrode configuration to provide positive and negative DC voltage pulses selectively to set/reset the memory states (“1”/“0”) without affecting the driving and sensing terminals. Excluding the energy cost for supporting electronics, these devices consume energy in 10’s of picojoules per logic/memory operations. Furthermore, the devices are fabricated using silicon on insulator (SOI) wafers, have the potential for on-chip integration, and operate at moderate pressure (~1 Torr) and room temperature.

A Microbeam Resonator with Partial Electrodes for Logic and Memory Elements

KAUST Repository

Hafiz, Md Abdullah Al; Ilyas, Saad; Ahmed, Sally; Younis, Mohammad I.; Fariborzi, Hossein

2017-01-01

We demonstrate logic and memory elements based on an in-plane clamped-clamped microbeam resonator. The micro-resonator is electrostatically actuated through a drive electrode and the motional signal is capacitively sensed at a sense electrode, while the resonance characteristics are modulated by DC voltage pulses provided at two separate partial electrodes, independent of the drive/sense electrodes. For the logic applications, we use two separate electrodes to provide DC voltages defined as the logic inputs. The high (low) motional signal at on-resonance (off-resonance) state is defined as the logic output state “1” (“0”). For the memory operation, two stable vibrational states, high and low, within the hysteretic regime are defined as the memory states, “1” and “0”, respectively. We take advantage of the split electrode configuration to provide positive and negative DC voltage pulses selectively to set/reset the memory states (“1”/“0”) without affecting the driving and sensing terminals. Excluding the energy cost for supporting electronics, these devices consume energy in 10’s of picojoules per logic/memory operations. Furthermore, the devices are fabricated using silicon on insulator (SOI) wafers, have the potential for on-chip integration, and operate at moderate pressure (~1 Torr) and room temperature.

Microbeam mapping of single event latchups and single event upsets in CMOS SRAMs

International Nuclear Information System (INIS)

Barak, J.; Adler, E.; Fischer, B.E.; Schloegl, M.; Metzger, S.

1998-01-01

The first simultaneous microbeam mapping of single event upset (SEU) and latchup (SEL) in the CMOS RAM HM65162 is presented. The authors found that the shapes of the sensitive areas depend on V DD , on the ions being used and on the site on the chip being hit by the ion. In particular, they found SEL sensitive sites close to the main power supply lines between the memory-bit-arrays by detecting the accompanying current surge. All these SELs were also accompanied by bit-flips elsewhere in the memory (which they call indirect SEUs in contrast to the well known SEUs induced in the hit memory cell only). When identical SEL sensitive sites were hit farther away from the supply lines only indirect SEL sensitive sites could be detected. They interpret these events as latent latchups in contrast to the classical ones detected by their induced current surge. These latent SELs were probably decoupled from the main supply lines by the high resistivity of the local supply lines

Nuclear micro-beam analysis of deuterium distribution in carbon fibre composites for controlled fusion devices

International Nuclear Information System (INIS)

Petersson, P.; Kreter, A.; Possnert, G.; Rubel, M.

2010-01-01

Probes made of carbon fibre composite NB41 were exposed to deuterium plasmas in the TEXTOR tokamak and in a simulator of plasma-wall interactions, PISCES. The aim was to assess the deuterium retention and its lateral and depth distribution. The analysis was performed by means of D( 3 He, p) 4 He and 12 C( 3 He, p) 14 N nuclear reactions analysis using a standard (1 mm spot) and micro-beam (20 μm resolution). The measurements have revealed non uniform distribution of deuterium atoms in micro-regions: differences by a factor of 3 between the maximum and minimum deuterium concentrations. The differences were associated with the orientation and type of fibres for samples exposed in PICSES. For surface structure in the erosion zone of samples exposed to a tokamak plasma the micro-regions were more complex. Depth profiling has indicated migration of fuel into the bulk of materials.

Remedial Investigation of Hanford Site Releases to the Columbia River - 13603

Energy Technology Data Exchange (ETDEWEB)

Lerch, J.A.; Hulstrom, L.C. [Washington Closure Hanford, LLC, Richland, Washington 99354 (United States); Sands, J.P. [U.S Department of Energy, Richland Operations Office, Richland, Washington 99352 (United States)

2013-07-01

In south-central Washington State, the Columbia River flows through the U.S. Department of Energy Hanford Site. A primary objective of the Hanford Site cleanup mission is protection of the Columbia River, through remediation of contaminated soil and groundwater that resulted from its weapons production mission. Within the Columbia River system, surface water, sediment, and biota samples related to potential Hanford Site hazardous substance releases have been collected since the start of Hanford operations. The impacts from release of Hanford Site radioactive substances to the Columbia River in areas upstream, within, and downstream of the Hanford Site boundary have been previously investigated as mandated by the U.S. Department of Energy requirements under the Atomic Energy Act. The Remedial Investigation Work Plan for Hanford Site Releases to the Columbia River [1] was issued in 2008 to initiate assessment of the impacts under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 [2]. The work plan established a phased approach to characterize contaminants, assess current risks, and determine whether or not there is a need for any cleanup actions. Field investigation activities over a 120-mile stretch of the Columbia River began in October 2008 and were completed in 2010. Sampled media included surface water, pore water, surface and core sediment, island soil, and fish (carp, walleye, whitefish, sucker, small-mouth bass, and sturgeon). Information and sample results from the field investigation were used to characterize current conditions within the Columbia River and assess whether current conditions posed a risk to ecological or human receptors that would merit additional study or response actions under CERCLA. The human health and ecological risk assessments are documented in reports that were published in 2012 [3, 4]. Conclusions from the risk assessment reports are being summarized and integrated with remedial investigation

Isotopic Tracking of Hanford 300 Area Derived Uranium in the Columbia River

Energy Technology Data Exchange (ETDEWEB)

Christensen, John N.; Dresel, P. Evan; Conrad, Mark E.; Patton, Gregory W.; DePaolo, Donald J.

2010-10-31

Our objectives in this study are to quantify the discharge rate of uranium (U) to the Columbia River from the Hanford Site's 300 Area, and to follow that U down river to constrain its fate. Uranium from the Hanford Site has variable isotopic composition due to nuclear industrial processes carried out at the site. This characteristic makes it possible to use high-precision isotopic measurements of U in environmental samples to identify even trace levels of contaminant U, determine its sources, and estimate discharge rates. Our data on river water samples indicate that as much as 3.2 kg/day can enter the Columbia River from the 300 Area, which is only a small fraction of the total load of dissolved natural background U carried by the Columbia River. This very low-level of Hanford derived U can be discerned, despite dilution to < 1 percent of natural background U, 350 km downstream from the Hanford Site. These results indicate that isotopic methods can allow the amounts of U from the 300 Area of the Hanford Site entering the Columbia River to be measured accurately to ascertain whether they are an environmental concern, or are insignificant relative to natural uranium background in the Columbia River.

Influence of the environment and phototoxicity of the live cell imaging system at IMP microbeam facility

Science.gov (United States)

Liu, Wenjing; Du, Guanghua; Guo, Jinlong; Wu, Ruqun; Wei, Junzhe; Chen, Hao; Li, Yaning; Zhao, Jing; Li, Xiaoyue

2017-08-01

To investigate the spatiotemporal dynamics of DNA damage and repair after the ion irradiation, an online live cell imaging system has been established based on the microbeam facility at Institute of Modern Physics (IMP). The system could provide a sterile and physiological environment by making use of heating plate and live cell imaging solution. The phototoxicity was investigated through the evaluation of DNA repair protein XRCC1 foci formed in HT1080-RFP cells during the imaging exposure. The intensity of the foci induced by phototoxicity was much lower compared with that of the foci induced by heavy ion hits. The results showed that although spontaneous foci were formed due to RFP exposure during live cell imaging, they had little impact on the analysis of the recruitment kinetics of XRCC1 in the foci induced by the ion irradiation.

Steelhead migration - Tracking steelhead migration from the Columbia River through the Pacific Ocean

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Tag juvenile Columbia River steelhead in the Columbia estuary with acoustic tags to determine their marine distributions. This was a small pilot project to test our...

Hydrologic bibliography of the Columbia River basalts in Washington

International Nuclear Information System (INIS)

Tanaka, H.H.; Wildrick, L.

1978-07-01

This bibliography is part of the hydrologic data compilation effort of the Columbia Plateau Hydrology Study, Rockwell Hanford Operations' Waste Isolation Program. It includes references on both surface and subsurface hydrology directly or indirectly related to the Washington State portion of the Columbia River basalts. A comprehensive, annotated bibliography of the Pasco Basin (including the Hanford site) hydrology has been prepared for Rockwell Hanford Operations under the Pasco Basin Hydrology Study. In order to avoid unnecessary duplication, no effort was made to include a complete list of bibliographic references on Hanford in this volume

Regional Sediment Budget of the Columbia River Littoral Cell, USA

Science.gov (United States)

Buijsman, Maarten C.; Sherwood, C.R.; Gibbs, A.E.; Gelfenbaum, G.; Kaminsky, G.M.; Ruggiero, P.; Franklin, J.

2002-01-01

Summary -- In this Open-File Report we present calculations of changes in bathymetric and topographic volumes for the Grays Harbor, Willapa Bay, and Columbia River entrances and the adjacent coasts of North Beach, Grayland Plains, Long Beach, and Clatsop Plains for four intervals: pre-jetty - 1920s (Interval 1), 1920s - 1950s (Interval 2), 1950s - 1990s (Interval 3), and 1920s 1990s (Interval 4). This analysis is part of the Southwest Washington Coastal Erosion Study (SWCES), the goals of which are to understand and predict the morphologic behavior of the Columbia River littoral cell on a management scale of tens of kilometers and decades. We obtain topographic Light Detection and Ranging (LIDAR) data from a joint project by the U.S. Geological Survey (USGS), National Oceanic and Atmospheric Administration (NOAA), National Aeronautic and Space Administration (NASA), and the Washington State Department of Ecology (DOE) and bathymetric data from the U.S. Coast and Geodetic Survey (USC&GS), U.S. Army Corps of Engineers (USACE), USGS, and the DOE. Shoreline data are digitized from T-Sheets and aerial photographs from the USC&GS and National Ocean Service (NOS). Instead of uncritically adjusting each survey to NAVD88, a common vertical land-based datum, we adjust some surveys to produce optimal results according to the following criteria. First, we minimize offsets in overlapping surveys within the same era, and second, we minimize bathymetric changes (relative to the 1990s) in deep water, where we assume minimal change has taken place. We grid bathymetric and topographic datasets using kriging and triangulation algorithms, calculate bathymetric-change surfaces for each interval, and calculate volume changes within polygons that are overlaid on the bathymetric-change surfaces. We find similar morphologic changes near the entrances to Grays Harbor and the Columbia River following jetty construction between 1898 and 1916 at the Grays Harbor entrance and between 1885 and

Columbia River System Operation Review : Final Environmental Impact Statement, Appendix N: Wildlife.

Energy Technology Data Exchange (ETDEWEB)

Columbia River System Operation Review (U.S.)

1995-11-01

The Columbia River System is a vast and complex combination of Federal and non-Federal facilities used for many purposes including power production, irrigation, navigation, flood control, recreation, fish and wildlife habitat and municipal and industrial water supply. Each river use competes for the limited water resources in the Columbia River Basin. This technical appendix addresses only the effects of alternative system operating strategies for managing the Columbia River system. The environmental impact statement (EIS) itself and some of the other appendices present analyses of the alternative approaches to the other three decisions considered as part of the SOR. This document is the product of the Wildlife Work Group, focusing on wildlife impacts but not including fishes. Topics covered include the following: scope and process; existing and affected environment, including specific discussion of 18 projects in the Columbia river basin. Analysis, evaluation, and alternatives are presented for all projects. System wide impacts to wildlife are also included.

Columbia River system operation review: Final environmental impact statement. Appendix N, wildlife

International Nuclear Information System (INIS)

1995-11-01

The Columbia River System is a vast and complex combination of Federal and non-Federal facilities used for many purposes including power production, irrigation, navigation, flood control, recreation, fish and wildlife habitat and municipal and industrial water supply. Each river use competes for the limited water resources in the Columbia River Basin. This technical appendix addresses only the effects of alternative system operating strategies for managing the Columbia River system. The environmental impact statement (EIS) itself and some of the other appendices present analyses of the alternative approaches to the other three decisions considered as part of the SOR. This document is the product of the Wildlife Work Group, focusing on wildlife impacts but not including fishes. Topics covered include the following: scope and process; existing and affected environment, including specific discussion of 18 projects in the Columbia river basin. Analysis, evaluation, and alternatives are presented for all projects. System wide impacts to wildlife are also included

Addressing climate change impacts and trans-boundary agreements on the Columbia River

International Nuclear Information System (INIS)

Vaddey, S.

2008-01-01

Research is showing that climate change could systematically affect hydrologic variability in the Columbia River basin. Changes in winter temperatures and mountain snowpack could result in increased winter flow, earlier peak flows, and decreased spring and summer flow volumes. Model results also show that snowpack in the Canadian portion of the Columbia basin is less sensitive to warming in comparison to portions of the basin in the U.S. and in turn could 'unbalance' current coordination agreements. These hydrologic changes are likely to result in impacts to operation of Columbia River dams that will require ongoing adaptations as warming progresses. The U.S. Army Corps of Engineers (USACE) is responsible for management of many hydropower and flood control projects on the Columbia River and its tributaries, and are thus expected to play an integral role in planning for and adapting to climate change in the Basin. USACE has worked closely with the Bureau of Reclamation (Reclamation), Bonneville Power Administration (BPA), resource agencies (USFWS, and NMFS) and tribal interests in dealing with Columbia River operations. Within this collaborative process there have been efforts to look at climate change impacts in operations planning; however, the efforts are just getting underway and they are not strongly coordinated among the various stakeholders. As preparations are being made for renewal of the Columbia River Treaty between Canada and the U.S. it is clear to all participants that a coordinated and comprehensive approach to consider climate impacts is required. This paper argues for and provides a framework for the implementation of a new comprehensive climate impacts program coordinated by stakeholders on the Columbia River. Such a program would address questions such as: What is the current range of predicted changes to streamflow and resulting system power generation? Under what framework would decisions be made as to where and when mitigation or adaptation

Studies of Columbia River water quality

International Nuclear Information System (INIS)

Onishi, Y.; Johanson, P.A.; Baca, R.G.; Hilty, E.L.

1976-01-01

The program to study the water quality of the Columbia River consists of two separate segments: sediment and radionuclide transport and temperature analysis. Quasi-two dimensional (longitudinal and vertical directions) mathematical simulation models were developed for determining radionuclide inventories, their variations with time, and movements of sediments and individual radionuclides in the freshwater region of the Columbia River below Priest Rapids Dam. These codes are presently being applied to the river reach between Priest Rapids and McNary Dams for the initial sensitivity analysis. In addition, true two-dimensional (longitudinal and lateral directions) models were formulated and are presently being programmed to provide more detailed information on sediment and radionuclide behavior in the river. For the temperature analysis program, river water temperature data supplied by the U. S. Geological Survey for six ERDA-sponsored temperature recording stations have been analyzed and cataloged on storage devices associated with ERDA's CDC 6600 located at Richland, Washington

British Columbia's untapped wind export potential

International Nuclear Information System (INIS)

Kaplan, M.

2008-01-01

This presentation discussed wind energy developments in British Columbia (BC). There are currently more than 5000 MW of wind power development activities in British Columbia, but only 325 MW of wind power purchase agreements (PPAs). Various renewable portfolio standards and greenhouse gas (GHG) initiatives are now being use to create demand for additional renewable energy development in the northwestern United States. Studies have demonstrated that BC wind export initiatives have the potential to deliver wind power to markets in the Pacific northwest. Canadian transmission export proposals are now examining methods of bringing renewable energy to areas with high load demands. However, the United States has more than 240,000 MW of proposed wind projects for key markets in the northwestern region. It was concluded that activities in United States wind development are now posing a challenge to Canadian wind energy exporters. Various transmission projects in the United States are now looking at developing renewable energy sources close to BC. tabs., figs

Columbia River Treaty 2014/2024 Review • Phase 1 Report

Energy Technology Data Exchange (ETDEWEB)

None

2010-07-01

Under the Columbia River Treaty (Treaty or CRT) of 1964, Canada and the United States (U.S.) jointly regulate and manage the Columbia River as it flows from British Columbia into the U.S. The Treaty has provided substantial flood control and power generation benefits to both nations. The Treaty established Canadian and U.S. Entities as implementing agents for each government. British Columbia Hydro and Power Authority (BC Hydro) was designated as the Canadian Entity. The Bonneville Power Administration (BPA) Administrator and the U.S. Army Corps of Engineers (Corps) Division Engineer, Northwestern Division, were designated as the U.S. Entity. The Canadian and U.S. Entities are empowered by their respective governments with broad discretion to implement the existing Columbia River Treaty. They are not, however, authorized to terminate, renegotiate, or otherwise modify the Treaty. In the U.S., authority over international treaties rests with the President, assisted in foreign relations and international negotiations by the Department of State and subject in certain cases to the advice and consent of the U.S. Senate. In Canada, international treaties are within the prerogative of the executive branch of the federal government. Under current policy, treaties are tabled in the House of Commons, and are subject to a waiting period before the executive branch brings the treaty into effect. In the case of the Columbia River Treaty, Canada has assigned certain rights and obligations relating to the Treaty to British Columbia pursuant to the Canada-B.C. Agreement. The Phase 1 report is provided to those respective governmental bodies to support possible independent and/or joint decisions that may be made with respect to the future of the Treaty. The Treaty contains two important provisions that take effect on and after September 16, 2024, that could impact the current power and flood control benefits: 1. Canadian flood control obligations automatically change from a pre

75 FR 24799 - Safety Zone; Tri-City Water Follies Hydroplane Races Practice Sessions, Columbia River, Kennewick...

Science.gov (United States)

2010-05-06

...-AA00 Safety Zone; Tri-City Water Follies Hydroplane Races Practice Sessions, Columbia River, Kennewick...-City Water Follies Association hosts annual hydroplane races on the Columbia River in Kennewick... Safety Zone; Tri-City Water Follies Hydroplane Races Practice Sessions, Columbia River, Kennewick, WA (a...

Investigation of groundwater seepage from the Hanford shoreline of the Columbia River

International Nuclear Information System (INIS)

McCormack, W.D.; Carlile, J.M.V.

1984-11-01

Groundwater discharges to the Columbia River are evaluated by the Hanford Environmental Surveillance and Groundwater Surveillance Programs via monitoring of the Columbia River and Hanford groundwater. Both programs concluded that Hanford groundwater has not adversely affected Columbia River water quality. This report supplements the above programs by investigating the general characteristics of groundwater entering the Columbia River from the Hanford Site. Specific objectives of the investigation were to identify general shoreline areas where Hanford-related materials were entering the river, and to evaluate qualitatively the physical characteristics and relative magnitudes of those discharges. The study was conducted in two phases. Phase 1 involved visual inspection of Columbia River shoreline, within the Hanford Site, for indications of groundwater seepage. As a result of that inspection, 115 springs suspected of discharging groundwater were recorded. During Phase 2, water samples were collected from these springs and analyzed for Hanford-related materials known to be present in the groundwater. The specific materials used as indicators for the majority of samples were tritium or uranium and nitrate. The magnitude and distribution of concentrations measured in the spring samples were consistent with concentrations of these materials measured in groundwater near the sampled spring locations. Water samples were also collected from the Columbia River to investigate the localized effects of groundwater discharges occurring above and below river level. These samples were collected within 2 to 4 m of the Hanford shoreline and analyzed for tritium, nitrate, and uranium. Elevated concentrations were measured in river samples collected near areas where groundwater and spring concentrations were elevated. All concentrations were below applicable DOE Concentration Guides. 8 references, 6 figures, 7 tables

PROTECTING GROUNDWATER & THE COLUMBIA RIVER AT THE HANFORD SITE

Energy Technology Data Exchange (ETDEWEB)

GERBER, M.S.

2006-06-29

Along the remote shores of the Columbia River in southeast Washington state, a race is on. Fluor Hanford, a prime cleanup contractor to the U.S. Department of Energy (DOE) at the Hanford Site, is managing a massive, multi-faceted project to remove contaminants from the groundwater before they can reach the Columbia. Despite the daunting nature and size of the problem--about 80 square miles of aquifer under the site contains long-lived radionuclides and hazardous chemicals--significant progress is being made. Many groups are watching, speaking out, and helping. A large. passionate, diverse, and geographically dispersed community is united in its desire to protect the Columbia River--the eighth largest in the world--and have a voice in Hanford's future. Fluor Hanford and the DOE, along with the US. Environmental Protection Agency (EPA) and the Washington Department of Ecology (Ecology) interact with all the stakeholders to make the best decisions. Together, they have made some remarkable strides in the battle against groundwater contamination under the site.

Columbia River ESI: MGT (Management Area Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive human-use data for Wildlife Refuges, National Forests, and State Parks for the Columbia River area. Vector polygons in this data set...

Ion microbeam analysis. Application to the study of the skin barrier and its nano-toxicology

International Nuclear Information System (INIS)

Simon, M.

2009-12-01

This work is dedicated to the use of ion microbeam irradiation to the study of a complex biological tissue like skin. Up to now, it has been very difficult to detect and track metallic oxides and manufactured nano-particles in biological tissues, most particularly in skin. Thus, it is essential to precise the mechanisms involved in skin barrier function processes face to exogenous agents like nano-particles and to characterize them in biological models in vitro/in vivo. During my work, I have had the opportunity to combine quantitative methods of analysis with high resolution imagery techniques (confocal microscopy, transmission electron microscopy and ion beam analysis) in order to characterize: (i) the skin barrier function of an ex vivo pig ear skin model understanding the ion homeostasis behavior face to different chemical or physical stresses; (ii) the impact on viability, accumulation and intracellular distribution of nano-particles (Titanium Oxides) naked or functionalized with fluorescent dyes (FITC, Rhodamine)

Survival Estimates for the Passage of Spring-Migrating Juvenile Salmonids through Snake and Columbia River Dams and Reservoirs, 2001-2002 Annual Report.

Energy Technology Data Exchange (ETDEWEB)

Zabel, Richard; Williams, John G.; Smith, Steven G. (Northwest and Alaska Fisheries Science Center, Fish Ecology Division, Seattle, WA)

2002-06-01

In 2001, the National Marine Fisheries Service and the University of Washington completed the ninth year of a study to estimate survival and travel time of juvenile salmonids (Oncorhynchus spp.) passing through dams and reservoirs on the Snake and Columbia Rivers. All estimates were derived from passive integrated transponder (PIT)-tagged fish. We PIT tagged and released at Lower Granite Dam a total of 17,028 hatchery and 3,550 wild steelhead. In addition, we utilized fish PIT tagged by other agencies at traps and hatcheries upstream of the hydropower system and sites within the hydropower system. PIT-tagged smolts were detected at interrogation facilities at Lower Granite, Little Goose, Lower Monumental, McNary, John Day, and Bonneville Dams and in the PIT-tag detector trawl operated in the Columbia River estuary. Survival estimates were calculated using the Single-Release Model. Primary research objectives in 2001 were to: (1) estimate reach and project survival and travel time in the Snake and Columbia Rivers throughout the yearling chinook salmon and steelhead migrations; (2) evaluate relationships between survival estimates and migration conditions; and (3) evaluate the survival-estimation models under prevailing conditions. This report provides reach survival and travel time estimates for 2001 for PIT-tagged yearling chinook salmon and steelhead (hatchery and wild) in the Snake and Columbia Rivers. Results are reported primarily in the form of tables and figures with a minimum of text. More details on methodology and statistical models used are provided in previous reports cited in the text. Results for summer-migrating chinook salmon will be reported separately.

Universities' Conflict-of-Interest Policies Are Doomed to Fail, Scholar Says

Science.gov (United States)

Guterman, Lila

2008-01-01

Kevin C. Elliott, an assistant professor of philosophy at the University of South Carolina at Columbia, asserts in the January issue of the journal "Accountability in Research" that the three pillars of academe's attempts to police conflict of interest--disclosure, management, and elimination of conflicts--are beset by serious flaws. Charges of…

Radionuclide concentrations in white sturgeon from the Columbia River

International Nuclear Information System (INIS)

Dauble, D.D.; Price, K.R.; Poston, T.M.

1993-11-01

The objectives of this study were to (1) review and summarize historical data on radionuclide concentrations in white sturgeon from the Columbia River, (2) determine present-day radionuclide tissue burdens from different locations in the Columbia River, and (3) compare historical data with current data. We first reviewed and summarized the historical literature on radionuclide concentrations in white sturgeon from the Hanford Reach. Field studies were then conducted to evaluate the relationship among sample locations, age/length of white sturgeon, and present radionuclide tissue burdens. Results and comparisons are discussed in the remainder of this report

Feasibility of storing radioactive wastes in Columbia River basalts

International Nuclear Information System (INIS)

Deju, R.A.

1976-01-01

In 1968 Atlantic Richfield Hanford Company initiated a study to assess the feasibility of final geologic storage of Hanford defense, radioactive waste in deep caverns constructed in the Columbia River flood basalts. The project, which included geologic studies, hydrologic tests, heat flow analysis, compatibility analysis, and tectonic studies, was suspended in 1972 before completion of interpretive work. In 1976 the interpretation and documentation were completed. These data may be valuable in qualifying the Columbia River flood basalts as a viable medium for final geologic storage of commercial radioactive waste. The findings to date are summarized, and the proposed future work is presented

Status Review of Wildlife Mitigation, Columbia Basin Hydroelectric Projects, Columbia River Mainstem Facilities, 1984 Final Report.

Energy Technology Data Exchange (ETDEWEB)

Howerton, Jack; Hwang, Diana

1984-11-01

This report reviews the status of past, present, and proposed future wildlife planning and mitigation programs at existing hydroelectric projects in the Columbia River Basin. The project evaluations will form the basis for determining any needed remedial measures or additional project analysis. Each hydropower facility report is abstracted separately for inclusion in the Energy Data Base.

Iteroparity in Columbia River summer-run steelhead (Oncorhynchus mykiss) : implications for conservation

International Nuclear Information System (INIS)

Keefer, M.L.; Boggs, C.T.; Peery, C.A.; Evans, A.F.

2008-01-01

This study examined the outmigration environment for steelhead kelts (anadromous rainbow trout, Oncorhynchus mykiss) in the Columbia River Basin, where summer-run kelts must pass up to 9 hydroelectric dams and reservoirs to reach the Pacific Ocean. Such fish passage barriers present many direct and indirect mortality hazards for outmigrating kelts. In some years, kelt migration mortality in the impounded portion of the system can be higher than 95 per cent. Current efforts to improve kelt survival in the Columbia system include increasing iteroparity to take advantage of genetic and demographic benefits of repeat spawners. Some of the basic iteroparity information gaps in the aggregated summer-run steelhead population of the interior Columbia River Basin were addressed in this study. Kelt demographics were collected along the outmigration corridor. Repeat spawner return rates were examined along with kelt demographics, outmigration timing and collection location and year. The roles of these factors in predicting repeat spawner returns were evaluated using an information-theoretic approach. The life history characteristics of returning fish was examined with reference to breeding interval, migration timing and distribution within the Columbia River Basin. The study tested whether repeat spawner return rates would be affected by outmigration distance and whether they would differ among demographic groups. It was concluded that the expression of iteroparity among interior Columbia River steelhead has persisted despite decades of impoundment-related selection pressures. Post spawn kelts and repeat spawners in downstream fish bypass systems at the Columbia River and Snake River dams were found to be disproportionately female and of wild origin. The results of this study provide baseline data for evaluating kelt mortality mitigation efforts and basic life history information for steelhead conservation planning. 78 refs., 4 tabs., 4 figs

CHaMP metrics - Columbia Habitat Monitoring Program

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The goal of CHaMP is to generate and implement a standard set of fish habitat monitoring (status and trend) methods in up to 26 watersheds across the Columbia River...

Tackling non-point source water pollution in British Columbia : an action plan

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

British Columbia`s approach to water quality management is discussed. The BC efforts include regulating `end of pipe` point discharges from industrial and municipal outfalls. The major remaining cause of water pollution is from non-point sources (NPS). NPS water pollution is caused by the release of pollutants from different and diffuse sources, mostly unregulated and associated with urbanization, agriculture and other forms of land development. The importance of dealing with such problems on an immediate basis to avoid a decline in water quality in the province is emphasized. Major sources of water pollution in British Columbia include: land development, agriculture, storm water runoff, onsite sewage systems, forestry, atmospheric deposition, and marine activities. 3 tabs.

Higher order modes excitation of electrostatically actuated clamped–clamped microbeams: experimental and analytical investigation

KAUST Repository

Jaber, Nizar

2016-01-06

© 2016 IOP Publishing Ltd. In this study, we demonstrate analytically and experimentally the excitations of the higher order modes of vibrations in electrostatically actuated clamped-clamped microbeam resonators. The concept is based on using partial electrodes with shapes that induce strong excitation of the mode of interest. The devices are fabricated using polyimide as a structural layer coated with nickel from the top and chrome and gold layers from the bottom. Experimentally, frequency sweeps with different electro-dynamical loading conditions are shown to demonstrate the excitation of the higher order modes of vibration. Using a half electrode, the second mode is excited with high amplitude of vibration compared with almost zero response using the full electrode. Also, using a two-third electrode configuration is shown to amplify the third mode resonance amplitude compared with the full electrode under the same electrical loading conditions. An analytical model is developed based on the Euler-Bernollui beam model and the Galerkin method to simulate the device response. Good agreement between the simulation results and the experimental data is reported.

Hard alpha-keratin degradation inside a tissue under high flux X-ray synchrotron micro-beam: a multi-scale time-resolved study.

Science.gov (United States)

Leccia, Emilie; Gourrier, Aurélien; Doucet, Jean; Briki, Fatma

2010-04-01

X-rays interact strongly with biological organisms. Synchrotron radiation sources deliver very intense X-ray photon fluxes within micro- or submicro cross-section beams, resulting in doses larger than the MGy. The relevance of synchrotron radiation analyses of biological materials is therefore questionable since such doses, million times higher than the ones used in radiotherapy, can cause huge damages in tissues, with regard to not only DNA, but also proteic and lipid organizations. Very few data concerning the effect of very high X-ray doses in tissues are available in the literature. We present here an analysis of the structural phenomena which occur when the model tissue of human hair is irradiated by a synchrotron X-ray micro-beam. The choice of hair is supported by its hierarchical and partially ordered keratin structure which can be analysed inside the tissue by X-ray diffraction. To assess the damages caused by hard X-ray micro-beams (1 microm(2) cross-section), short exposure time scattering SAXS/WAXS patterns have been recorded at beamline ID13 (ESRF) after various irradiation times. Various modifications of the scattering patterns are observed, they provide fine insight of the radiation damages at various hierarchical levels and also unexpectedly provide information about the stability of the various hierarchical structural levels. It appears that the molecular level, i.e. the alpha helices which are stabilized by hydrogen bonds and the alpha-helical coiled coils which are stabilized by hydrophobic interactions, is more sensitive to radiation than the supramolecular architecture of the keratin filament and the filament packing within the keratin associated proteins matrix, which is stabilized by disulphide bonds. (c) 2009 Elsevier Inc. All rights reserved.

Alpha-particles microbeam irradiation: impact of reactive oxygen species in bystander effect

International Nuclear Information System (INIS)

Hanot, M.

2008-11-01

Ionizing radiation-induced bystander effects arise in bystander cells that receive signals from directly irradiated cells. To date, free radicals are believed to play an active role in the bystander response, but this is incompletely characterized. To mark temporal and spatial impacts of bystander effect, we employed a precise α-particle microbeam to target a small fraction of sub-confluent osteoblastic cell cultures (MC3T3-E1). We identified the cellular membrane and mitochondria like two distinct places generating reactive oxygen species. The global oxidative stress observed after irradiation was significantly attenuated after filipin treatment, evidencing the pivotal role of membrane in MC3T3-E1 cells bystander response. To determine impact of bystander effect at a cell level, cellular consequences of this membrane-dependant bystander effect were then investigated. A variable fraction of the cell population (10 to 100%) was individually targeted. In this case, mitotic death and micronuclei yield both increased in bystander cells as well as in targeted cells demonstrating a role of bystander signals between irradiated cells in an autocrine or paracrine manner. Our results indicate a complex interaction of direct irradiation and bystander signals that lead to a membrane-dependant amplification of cell responses. (author)

Columbia River ESI: NWI (National Wetlands Inventory - Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains vector polygons representing the wetlands of Columbia River classified according to the Environmental Sensitivity Index (ESI) classification...

Laboratory Assessment of Potential Impacts to Dungeness Crabs from Disposal of Dredged Material from the Columbia River

Energy Technology Data Exchange (ETDEWEB)

Vavrinec, John; Pearson, Walter H.; Kohn, Nancy P.; Skalski, J. R.; Lee, Cheegwan; Hall, Kathleen D.; Romano, Brett A.; Miller, Martin C.; Khangaonkar, Tarang P.

2007-05-07

Dredging of the Columbia River navigation channel has raised concerns about dredging-related impacts on Dungeness crabs (Cancer magister) in the estuary, mouth of the estuary, and nearshore ocean areas adjacent to the Columbia River. The Portland District, U.S. Army Corps of Engineers engaged the Marine Sciences Laboratory (MSL) of the U.S. Department of Energy’s Pacific Northwest National Laboratory to review the state of knowledge and conduct studies concerning impacts on Dungeness crabs resulting from disposal during the Columbia River Channel Improvement Project and annual maintenance dredging in the mouth of the Columbia River. The present study concerns potential effects on Dungeness crabs from dredged material disposal specific to the mouth of the Columbia River.

The acoustic streamflow-measuring system on the Columbia River at The Dalles, Oregon

Science.gov (United States)

Smith, Winchell; Hubbard, Larry L.; Laenen, Antonius

1971-01-01

Records of discharge on the Columbia River at The Dalles, Oreg., are vital to the management of the complex water-development projects in the Columbia River basin. Accurate discharge figures are needed for consistent day-to-day management and are required to meet treaty obligations with Canada.

Dynamic pull-in instability of geometrically nonlinear actuated micro-beams based on the modified couple stress theory

Directory of Open Access Journals (Sweden)

Hamid M. Sedighi

Full Text Available This paper investigates the dynamic pull-in instability of vibrating micro-beams undergoing large deflection under electrosatically actuation. The governing equation of motion is derived based on the modified couple stress theory. Homotopy Perturbation Method is employed to produce the high accuracy approximate solution as well as the second-order frequency- amplitude relationship. The nonlinear governing equation of micro beam vibrations predeformed by an electric field includes both even and odd nonlinearities. The influences of basic non-dimensional parameters on the pull-in instability as well as the natural frequency are studied. It is demonstrated that two terms in series expansions are sufficient to produce high accuracy solution of the micro-structure. The accuracy of proposed asymptotic approach is validated via numerical results. The phase portrait of the system exhibits periodic and homoclinic orbits.

Transforming First Nations Health Care in British Columbia: An Organizational Challenge

Directory of Open Access Journals (Sweden)

Stephen Wilmot

2018-02-01

Full Text Available Following a series of agreements on First Nations health care in British Columbia beginning in 2005, several organizations were created to contribute to the development of a system of health care for First Nations in the province, with the aim of transforming First Nations health care to better meet users’ needs. This article considers the role of these organizations and their relationships with the provincial government, the federal government, and the First Nations people of British Columbia. It explores possible levels of transformation, as well as the possibilities and problems for these organizations in undertaking the transformation process, particularly with regard to their position on the boundary between the worlds of First Nations and Canada. It also considers sources of, and threats to, their legitimacy in this undertaking. Finally, wider points of relevance beyond British Columbia are identified.

Provincial land use planning in British Columbia

International Nuclear Information System (INIS)

Mitchell, W.

1998-01-01

The efforts being made to include Aboriginal communities in land use planning in British Columbia are discussed. British Columbia is in the midst of historic changes with respect to land and resource allocation, use and management. Historic trends in land use allocation and management are contrasted with land use planning and resource management of today. The impact of provincial government moves to double park space within the province, and the Protected Areas Strategy initiative will have on the natural gas and petroleum industry is discussed. New efforts being made to include First Nations directly in land use planning discussions in ways that do not prejudice treaty negotiations, are reviewed. Creation of a new Oil and Gas Commission in the Fort St. John area, is cited as the most recent example of the interconnections between First Nations communities and other public and industry stakeholders in land use planning in the province

Immunization delivery in British Columbia

Science.gov (United States)

Omura, John; Buxton, Jane; Kaczorowski, Janusz; Catterson, Jason; Li, Jane; Derban, Andrea; Hasselback, Paul; Machin, Shelagh; Linekin, Michelle; Morgana, Tamsin; O’Briain, Barra; Scheifele, David; Dawar, Meena

2014-01-01

Abstract Objective To explore the experiences of family physicians and pediatricians delivering immunizations, including perceived barriers and supports. Design Qualitative study using focus groups. Setting Ten cities throughout British Columbia. Participants A total of 46 family physicians or general practitioners, 10 pediatricians, and 2 residents. Methods A semistructured dialogue guide was used by a trained facilitator to explore participants’ experiences and views related to immunization delivery in British Columbia. Verbatim transcriptions were independently coded by 2 researchers. Key themes were analyzed and identified in an iterative manner using interpretive description. Main findings Physicians highly valued vaccine delivery. Factors facilitating physician-delivered immunizations included strong beliefs in the value of vaccines and having adequate information. Identified barriers included the large time commitment and insufficient communication about program changes, new vaccines, and the adult immunization program in general. Some physicians reported good relationships with local public health, while others reported the opposite experience, and this varied by geographic location. Conclusion These findings suggest that physicians are supportive of delivering vaccines. However, there are opportunities to improve the sustainability of physician-delivered immunizations. While compensation schemes remain under the purview of the provincial governments, local public health authorities can address the information needs of physicians. PMID:24627403

Columbia River ESI: HYDRO (Hydrography Lines and Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains vector lines and polygons representing coastal hydrography used in the creation of the Environmental Sensitivity Index (ESI) for Columbia...

Columbia River system operation review. Final environmental impact statement. Appendix J, recreation

International Nuclear Information System (INIS)

1995-11-01

This Appendix J of the Final Environmental Impact Statement for the Columbia River System discusses impacts on the recreational activities in the region. Major sections include the following: scope and processes; recreation in the Columbia River Basin today - by type, location, participation, user characteristics, factors which affect usage, and managing agencies; recreation analysis procedures and methodology; and alternatives and their impacts

Columbia River System Operation Review : Final Environmental Impact Statement, Appendix J: Recreation.

Energy Technology Data Exchange (ETDEWEB)

Columbia River System Operation Review (U.S.)

1995-11-01

This Appendix J of the Final Environmental Impact Statement for the Columbia River System discusses impacts on the recreational activities in the region. Major sections include the following: scope and processes; recreation in the Columbia River Basin today - by type, location, participation, user characteristics, factors which affect usage, and managing agencies; recreation analysis procedures and methodology; and alternatives and their impacts.

75 FR 66009 - Airworthiness Directives; Cessna Aircraft Company (Type Certificate Previously Held by Columbia...

Science.gov (United States)

2010-10-27

... Company (Type Certificate Previously Held by Columbia Aircraft Manufacturing (Previously the Lancair... Company (Type Certificate Previously Held by Columbia Aircraft Manufacturing (Previously The Lancair...-15895. Applicability (c) This AD applies to the following Cessna Aircraft Company (type certificate...

Preliminary feasibility study on storage of radioactive wastes in Columbia River basalts. Volume I

International Nuclear Information System (INIS)

1976-11-01

Geologic, hydrologic, heat transfer and rock-waste compatibility studies conducted by the Atlantic Richfield Hanford Company to evaluate the feasibility of storing nuclear wastes in caverns mined out into the Columbia River basalts are discussed. The succession of Columbia River Plateau flood basalts was sampled at various outcrops and in core holes and the samples were analyzed to develop a stratigraphic correlation of the various basalt units and sedimentary interbeds. Hydrologic tests were made in one bore hole to assess the degree of isolation in the various deep aquifers separated by thick basalt accumulations. Earthquake and tectonic studies were conducted to assess the tectonic stability of the Columbia River Plateau. Studies were made to evaluate the extent of heat dissipation from stored radioactive wastes. Geochemical studies were aimed at evaluating the compatibility between the radioactive wastes and the basalt host rocks. Data obtained to-date have allowed development of a hydrostratigraphic framework for the Columbia River Plateau and a preliminary understanding of the deep aquifer systems. Finally, the compilation of this information has served as a basis for planning the studies necessary to define the effectiveness of the Columbia River basalts for permanently isolating nuclear wastes from the biosphere

Navy Columbia Class (Ohio Replacement) Ballistic Missile Submarine (SSBN[X]) Program: Background and Issues for Congress

Science.gov (United States)

2016-08-18

25 Legislative Activity for FY2017...of 14 Ohio-class SSBNs, all of which are armed with D-5 SLBMs. Eight of the 14 Ohio-class SSBNs are homeported at Bangor, WA , in Puget Sound; the...Navy’s plan to design and procure Columbia- class boats. Columbia Class Program Program Name For several years, the Columbia class program was known

Columbia River ESI: T_MAMMAL (Terrestrial Mammal Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for beavers, otters, nutria, mink, muskrats, and Columbian white-tailed deer in the Columbia River area....

Columbia Basin residents' view on water : final report

International Nuclear Information System (INIS)

Ronalds, L.

2005-01-01

Currently, there is no strategic plan for water management in the Columbia Basin to ensure that long-term water quality and quantity issues are addressed according to residents' values and views. The Columbia Basin Trust was therefore created to address water management issues. It devised a comprehensive water information questionnaire and sent it to a broad range of respondents that fell within the Canadian portion of the Columbia Basin. These included municipal, regional, provincial and federal government agencies; community and watershed groups; industry and agriculture groups; recreation and tourism groups; and, First Nations groups. The most prevalent concern among the respondents pertained to issues surrounding domestic water consumption, and the most widespread water issue in the Columbia Basin was that of water conservation. The state of aquatic ecosystems was also of significant importance to respondents. Respondents also expressed concern for the cost of providing potable water and for the sustainability of rivers and their tributaries within the Basin. The survey also found a concern for the fluctuating reservoir levels within the Basin and the protection of drinking water from contamination. In order to address the wide range of water related issues, respondents indicated that an education program should be implemented to address the general nature of the hydrologic cycle; how much water is being used for toilets, lawn watering, and showers; the cost of potable water; the importance of water on a local and global level; the importance and nature of watersheds; the ways people influence and pollute water; the challenges of cleaning up contaminated water sources; the community's water sources; the role of water in sustaining food growth; and, challenges and consequences of other communities that experience severe water quality and quantity issues. It was suggested that the education program should address a water conservation plan, including conservation

Radionuclide releases to the Columbia River from Hanford Operations, 1944--1971

International Nuclear Information System (INIS)

Heeb, C.M.; Bates, D.J.

1994-05-01

The purpose of the Hanford Environmental Dose Reconstruction (HEDR) Project is to estimate the radiation dose that individuals could have received as a result of radionuclide emissions since 1944 from the Hanford Site. One source of radionuclide releases to the Columbia River was from production reactor operations. This report provides a quantitative estimate of the amount of radioactivity released each month (1944--1971) to the Columbia River from eleven radionuclides as well as from gross beta activity

Columbia River ESI: REPTILES (Reptile and Amphibian Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for western pond turtles and western painted turtles in Columbia River. Vector polygons in this data set...

Columbia River ESI: M_MAMMAL (Marine Mammal Polygons)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for Steller sea lions, harbor seals, and California sea lions in Columbia River. Vector polygons in this...

Comparison of proton microbeam and gamma irradiation for the radiation hardness testing of silicon PIN diodes

Science.gov (United States)

Jakšić, M.; Grilj, V.; Skukan, N.; Majer, M.; Jung, H. K.; Kim, J. Y.; Lee, N. H.

2013-09-01

Simple and cost-effective solutions using Si PIN diodes as detectors are presently utilized in various radiation-related applications in which excessive exposure to radiation degrades their charge transport properties. One of the conventional methods for the radiation hardness testing of such devices is time-consuming irradiation with electron beam or gamma-ray irradiation facilities, high-energy proton accelerators, or with neutrons from research reactors. Recently, for the purpose of radiation hardness testing, a much faster nuclear microprobe based approach utilizing proton irradiation has been developed. To compare the two different irradiation techniques, silicon PIN diodes have been irradiated with a Co-60 gamma radiation source and with a 6 MeV proton microbeam. The signal degradation in the silicon PIN diodes for both irradiation conditions has been probed by the IBIC (ion beam induced charge) technique, which can precisely monitor changes in charge collection efficiency. The results presented are reviewed on the basis of displacement damage calculations and NIEL (non-ionizing energy loss) concept.

Comparative Dosimetric Estimates of a 25 keV Electron Micro-beam with three Monte Carlo Codes

CERN Document Server

Mainardi, E; Donahue, R J

2002-01-01

The calculations presented compare the different performances of the three Monte Carlo codes PENELOPE-1999, MCNP-4C and PITS, for the evaluation of Dose profiles from a 25 keV electron micro-beam traversing individual cells. The overall model of a cell is a water cylinder equivalent for the three codes but with a different internal scoring geometry: hollow cylinders for PENELOPE and MCNP, whereas spheres are used for the PITS code. A cylindrical cell geometry with scoring volumes with the shape of hollow cylinders was initially selected for PENELOPE and MCNP because of its superior simulation of the actual shape and dimensions of a cell and for its improved computer-time efficiency if compared to spherical internal volumes. Some of the transfer points and energy transfer that constitute a radiation track may actually fall in the space between spheres, that would be outside the spherical scoring volume. This internal geometry, along with the PENELOPE algorithm, drastically reduced the computer time when using ...

Academic Advising in British Columbia. Executive Summary

Science.gov (United States)

British Columbia Council on Admissions and Transfer, 2016

2016-01-01

"Advising" consists of those activities and tasks that result in providing information to students. British Columbia's (BC) post-secondary education has evolved over the past number of years and student advising has changed along with it. Post-secondary institutions are currently challenged to increase student engagement, improve…

Oil spill response planning on the Columbia river estuary

International Nuclear Information System (INIS)

Christopherson, S.K.; Slyman, P.M.

1993-01-01

The Columbia River Estuary lies along the Washington-Oregon state boundary on the west coast of the United States. The entire area is environmentally very sensitive with numerous large, shallow bays, exposed mud flats, wetland areas, and central channels having maximum currents of three to four knots. These features make the area very difficult to protect from an oil spill. Spill response is further complicated because of the many different state, federal, and local jurisdictions with mandated responsibilities in oil spill response and environmental protection. Under the leadership of the US Coast Guard Marine Safety Office in Portland, Oregon, a steering group was established to guide the development of a response plan for the Columbia River Estuary. A concerted effort was made to include representatives from response organizations, natural resource agencies, and resource users from federal, state, and local governments, and commercial sectors in the planning process. The first draft of an operational response plan was completed the summer of 1992 through a combination of technical workshops, field trips, and small working groups meeting with local communities. The Columbia River Estuary Response Plan prioritizes areas to protect; identifies specific response strategies for protecting these areas; and outlines the Iogistics needed to implement these strategies, including equipment needs, the location of staging areas, and the identification of pre-designed command posts. The local spill response cooperative and oil transportation industry are using the plan to coordinate the purchase of response equipment and the staging of this equipment at numerous locations along the river. The key to success is ensuring that all the groups responding to an event participate in the planning process together. This process has worked well and will serve as a model for response planning for other areas along the Columbia River and coastal areas of Washington and Oregon

Developing the New Columbia Core Curriculum: A Case Study in Managing Radical Curriculum Change

Science.gov (United States)

Galea, Sandro; Fried, Linda P.; Walker, Julia R.; Rudenstine, Sasha; Glover, Jim W.

2015-01-01

Curricular change is essential for maintaining vibrant, timely, and relevant educational programming. However, major renewal of a long-standing curriculum at an established university presents many challenges for leaders, faculty, staff, and students. We present a case study of a dramatic curriculum renewal of one of the nation’s largest Master of Public Health degree programs: Columbia University’s Mailman School of Public Health. We discuss context, motivation for change, the administrative structure established to support the process, data sources to inform our steps, the project timeline, methods for engaging the school community, and the extensive planning that was devoted to evaluation and communication efforts. We highlight key features that we believe are essential for successful curricular change. PMID:25706010

Bibliography of the geology of the Columbia Basin and surrounding areas of Washington

International Nuclear Information System (INIS)

Tucker, G.B.; Rigby, J.G.

1979-07-01

In the fall of 1977, the Washington State Department of Natural Resources, Division of Geology and Earth Resources (WDGER), entered into a contract with the US Department of Energy, administered by Rockwell Hanford Operations (Rockwell) in Richland, Washington, as a principal contributor to a geologic study of feasibility of storing radioactive waste within Columbia River basalt. WDGER's responsibility was the production of this bibliography and a reconnaissance geologic map of the sediments overlying the Columbia River Basalt Group in the State of Washington. This bibliography is a compilation of all known published, unpublished, and open-file references dealing with geology and geophysics of the Columbia Basin of eastern Washington. The citations were obtained primarily from the WDGER and Washington State libraries; the Geo-Ref bibliographic system was also utilized. Because the WDGER portion of the study included preparation of a reconnaissance geologic map of surficial deposits in the Columbia Basin, available references dealing with this subject have been annotated. Many abstracts in the annotated section are quotations and have been copied directly from their respective publications

Bibliography of the geology of the Columbia Basin and surrounding areas of Washington

Energy Technology Data Exchange (ETDEWEB)

Tucker, G.B.; Rigby, J.G.

1979-07-01

In the fall of 1977, the Washington State Department of Natural Resources, Division of Geology and Earth Resources (WDGER), entered into a contract with the US Department of Energy, administered by Rockwell Hanford Operations (Rockwell) in Richland, Washington, as a principal contributor to a geologic study of feasibility of storing radioactive waste within Columbia River basalt. WDGER's responsibility was the production of this bibliography and a reconnaissance geologic map of the sediments overlying the Columbia River Basalt Group in the State of Washington. This bibliography is a compilation of all known published, unpublished, and open-file references dealing with geology and geophysics of the Columbia Basin of eastern Washington. The citations were obtained primarily from the WDGER and Washington State libraries; the Geo-Ref bibliographic system was also utilized. Because the WDGER portion of the study included preparation of a reconnaissance geologic map of surficial deposits in the Columbia Basin, available references dealing with this subject have been annotated. Many abstracts in the annotated section are quotations and have been copied directly from their respective publications.

76 FR 44587 - Notice to All Interested Parties of the Termination of the Receivership of 7439, Columbia Savings...

Science.gov (United States)

2011-07-26

... Receivership of 7439, Columbia Savings and Loan Association, Beverly Hills, CA Notice is hereby given that the Federal Deposit Insurance Corporation (``FDIC'') as Receiver for Columbia Savings and Loan Association... Resolution Trust Corporation (``RTC'') was appointed Receiver for Columbia Savings and Loan Association and...

Proceedings of the 4th workshop on ion-beam-applied biology

International Nuclear Information System (INIS)

Kobayashi, Yasuhiko; Funayama, Tomoo; Wada, Seiichi; Hamada, Nobuyuki

2005-09-01

In order to promote research on biological application using ion beam at TIARA, we have annually hold the Workshop on Ion-beam-applied Biology at JAERI Takasaki since 2002. The 4th workshop entitled 'New Frontiers of Biological Research using microbeam - Application to Radio-microsurgery and Cellular Response to Radiations -' was held on June 22nd, 2005, aimed to overview the recent progress in microbeam-applied researches, and discuss the future direction of application of microbeam not to researches in life science and biotechnology, but also to clinical medicine. This workshop was hosted by JAERI Takasaki, with the cooperation of The Ion Beam Breeding Society, The Japan Radiation Research Society, The Japanese Society for Biological Sciences in Space, The Kanto-Kohetsu Branch of The Atomic Energy Society of Japan, and The Japan Radioisotope Association. There were 104 participants including clinicians attended from universities, public research institutions, and private companies. The papers presented in the workshop were about the ion-beam-applied biological researches at JAERI, the present status of microbeam facilities in Japan and foreign countries, and the microbeam-based analyses of damage repair machinery in insects and radiation-induced bystander effects. It was realized again that microbeam is quite useful for functional analyses by targeted disruption of specific tissues in bio-organisms, and is of critical importance in investigating biological influences of low-dose radiations as well as in its radiological application. These researches using microbeam are expected to further march on. The 13 of the presented papers are indexed individually. (J.P.N.)

75 FR 41762 - Safety Zone; Annual Kennewick, WA, Columbia Unlimited Hydroplane Races, Kennewick, WA

Science.gov (United States)

2010-07-19

...-AA00 Safety Zone; Annual Kennewick, WA, Columbia Unlimited Hydroplane Races, Kennewick, WA AGENCY..., Columbia Unlimited Hydroplane Races'' also known as the Tri-City Water Follies Hydroplane Races. The safety... power and responsibilities between the Federal Government and Indian tribes. Energy Effects We have...

Investigation of double strand breaks induced by alpha particle irradiation using C.N.B.G. microbeam in human keratinocytes

International Nuclear Information System (INIS)

Pouthier, Th.

2006-12-01

To understand the mechanisms of interaction of ionizing radiation with living tissues exposed to low and protracted doses remains a major issue for risk evaluation. The response cannot be found in epidemiological studies because the only available data concern accidental exposures to high doses of radiation. The natural exposure represents the main source of exposure in the daily life, just before the medical sources (radiology, radiotherapy). In addition, this kind of exposure is very difficult to reproduce in vitro by irradiating cell lines. The method per preference is based on random irradiation of cell populations. The mean number of particles having traversed cells is then calculated on the basis of Poisson statistics. In addition to inevitable multiple impacts, the numerous potential intracellular targets (nuclei, cytoplasm), the indirect effects induced by the impact of particles on neighbouring cells or simply the extracellular targets, constitute phenomena that make more complex the interpretation of experimental data. A charged particle microbeam was developed at C.E.N.B.G. to perform the targeted irradiation of individual cells with a targeting precision of a few microns. It is possible to deliver a counted number of alpha particles down to the ultimate dose of one alpha per cell, to target predetermined cells and then to observe the response of the neighbouring cells. This facility has been validated during this work on human keratinocyte cells expressing a recombinant nuclear fluorescent protein (histone H2B-GFP). The combination of ion micro-beams with confocal microscopy and numeric quantitative analysis allowed the measurement of DNA double strand breaks via the phosphorylation of the histone H2A.X in individual cells. The mechanisms of DNA reparation and apoptosis induction were also in the scope of those studies. The experimental results obtained during this thesis validate the methodology we have developed by demonstrating the targeting

33 CFR 162.225 - Columbia and Willamette Rivers, Washington and Oregon; administration and navigation.

Science.gov (United States)

2010-07-01

... the river as appropriate such temporary speed regulations as he may deem necessary to protect the... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Columbia and Willamette Rivers... NAVIGATION REGULATIONS § 162.225 Columbia and Willamette Rivers, Washington and Oregon; administration and...

Maryland and District of Columbia State Briefing Book for low-level radioactive waste management

International Nuclear Information System (INIS)

1981-09-01

The District of Columbia and Maryland State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state and federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in the District of Columbia and Maryland. The profile is the result of a survey of NRC licensees in the District of Columbia and Maryland. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in the District of Columbia and Maryland

Considerations for Education Reform in British Columbia

Science.gov (United States)

Santos, Ana

2012-01-01

Countries around the world refer to twenty-first century education as essential to maintaining personal and national economic advantage and draw on this discourse to advocate for and embark on educational reform. This paper examines issues around education reform, particularly in British Columbia. It argues that reformers should give careful…

The Effect of an Added Mass on the Frequency Shifts of a Clamped-Clamped Microbeam for Bio-Mass Detection

KAUST Repository

Bouchaala, Adam M.

2016-12-05

We present analytical formulations to calculate the induced resonance frequency shifts of electrically actuated clamped-clamped microbeams due to an added mass. Based on the Euler-Bernoulli beam theory, we investigate the linear dynamic responses of the beams added masses, which are modeled as discrete point masses. Analytical expressions based on perturbation techniques and a one-mode Galerkin approximation are developed to calculate accurately the frequency shifts under a DC voltage as a function of the added mass and position. The analytical results are compared to numerical solution of the eigenvalue problem. Results are shown for the fundamental as well as the higher-order modes of the beams. The results indicate a significant increase in the frequency shift, and hence the sensitivity of detection, when scaling down to nano scale and using higher-order modes.

The Effect of an Added Mass on the Frequency Shifts of a Clamped-Clamped Microbeam for Bio-Mass Detection

KAUST Repository

Bouchaala, Adam M.; Nayfeh, Ali H.; Younis, Mohammad I.

2016-01-01

We present analytical formulations to calculate the induced resonance frequency shifts of electrically actuated clamped-clamped microbeams due to an added mass. Based on the Euler-Bernoulli beam theory, we investigate the linear dynamic responses of the beams added masses, which are modeled as discrete point masses. Analytical expressions based on perturbation techniques and a one-mode Galerkin approximation are developed to calculate accurately the frequency shifts under a DC voltage as a function of the added mass and position. The analytical results are compared to numerical solution of the eigenvalue problem. Results are shown for the fundamental as well as the higher-order modes of the beams. The results indicate a significant increase in the frequency shift, and hence the sensitivity of detection, when scaling down to nano scale and using higher-order modes.

76 FR 17843 - Intent To Compromise Claim Against the District of Columbia Public Schools

Science.gov (United States)

2011-03-31

... District of Columbia Public Schools (DCPS) now pending before the Office of Administrative Law Judges (OALJ... DEPARTMENT OF EDUCATION Intent To Compromise Claim Against the District of Columbia Public Schools... Application for Review of this PDL with the Office of Administrative Law Judges (OALJ) on September 10, 2007...

24 CFR 597.502 - Nominations by economic development corporations or the District of Columbia.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Nominations by economic development corporations or the District of Columbia. 597.502 Section 597.502 Housing and Urban Development Regulations... development corporations or the District of Columbia. Any urban area nominated by an Economic Development...

Gonad organochlorine concentrations and plasma steroid levels in white sturgeon (Acipenser transmontanus) from the Columbia River, USA

Science.gov (United States)

Foster, E.P.; Fitzpatrick, M.S.; Feist, G.W.; Schreck, C.B.; Yates, J.

2001-01-01

Sturgeon are an important fishery resource world-wide, providing food and income through commercial, sport, and tribal fisheries. However, sturgeon populations are imperiled in many areas due to overharvest, habitat loss, and pollution. White Sturgeon (Acipenser transmontanus) are found along the west coast of North America from San Francisco Bay, USA to British Columbia, Canada. The Columbia River, located in the Pacific Northwest USA, supports active commercial, sport, and tribal white sturgeon fisheries. The white sturgeon fishery in the Columbia River estuary is one of the most productive sturgeon fisheries in the World. Despite the success of the Columbia River estuary white sturgeon fishery, the populations within the impounded sections (i.e. behind the hydroelectric dams) of the Columbia River experience poor reproductive success (Beamesderfer et al. 1995). This poor reproductive success has been attributed to hydroelectric development, but water pollution could also be a significant factor. The bottom dwelling life history and late maturing reproductive strategy for this species may make it particularly sensitive to the adverse effects of bioaccumulative pollutants.The Columbia River receives effluent from bleached-kraft pulp mills, aluminum smelters, municipal sewage treatment plants and runoff from agricultural. industrial, and urban areas. Bioaccumulative contaminants that have the potential for endocrine disruption have been detected in fish and sediments from the Columbia River (Foster et al. 1999). An integrated system of hormones control reproduction in vertebrates. Plasma steroids direct developmental events essential for reproduction. Disruption of endocrine control by contaminants has been linked to reproductive anomalies and failure in a number of vertebrate species (Guillette et al. 1996; Jobling et al. 1996). Because of this, it is important to understand if organochlorine compounds are accumulating in Columbia River white sturgeon and having

British Columbia at the crossroads: clean energy or more pollution?

Energy Technology Data Exchange (ETDEWEB)

Foley, D.; Hertzog, S.; Scott, G. (eds.)

2001-11-01

Some of the challenges facing policy makers as we enter this century are related to regional air pollution and global climate change, where both are a consequence of the combustion of fossil fuels. Data on smog and particulates has been compiled for decades by medical authorities and regulators, thereby documenting the causes, the characteristics and the impact of global warming. Sustainable energy policies are required. A historic compromise was forged in July 2001 on how to implement the 1997 Kyoto Protocol. It is increasingly important for Canada to make energy policy decisions that support the protection of the climate. Key aspects of human activity, such as tourism, forestry, fishing, agriculture, water supplies and flows, infrastructure reliability and costs, and public health factors are at risk in British Columbia. For British Columbia to comply with the Kyoto Protocol, some sources would be able to expand emissions while others would have to reduce them much more to achieve an overall reduction. This document represents an outline and a vision for new opportunities and analyses the challenges facing energy patterns in British Columbia. It was presented to the British Columbia (BC) Energy Policy Task Force. This broad policy review is an ideal opportunity to build energy policies and related economic initiatives leading to new industries, new jobs, and increased energy security. The document is divided in five parts: the BC situation: trends and impacts, BC Hydro and the rush to gas, the BC gas turbine experience: conflict and controversy, gas and the changing dynamics of the BC energy market, and the clean energy path: lessons and policy recommendations. refs., 1 tab., 4 figs.

British Columbia at the crossroads: clean energy or more pollution?

International Nuclear Information System (INIS)

Foley, D.; Hertzog, S.; Scott, G.

2001-11-01

Some of the challenges facing policy makers as we enter this century are related to regional air pollution and global climate change, where both are a consequence of the combustion of fossil fuels. Data on smog and particulates has been compiled for decades by medical authorities and regulators, thereby documenting the causes, the characteristics and the impact of global warming. Sustainable energy policies are required. A historic compromise was forged in July 2001 on how to implement the 1997 Kyoto Protocol. It is increasingly important for Canada to make energy policy decisions that support the protection of the climate. Key aspects of human activity, such as tourism, forestry, fishing, agriculture, water supplies and flows, infrastructure reliability and costs, and public health factors are at risk in British Columbia. For British Columbia to comply with the Kyoto Protocol, some sources would be able to expand emissions while others would have to reduce them much more to achieve an overall reduction. This document represents an outline and a vision for new opportunities and analyses the challenges facing energy patterns in British Columbia. It was presented to the British Columbia (BC) Energy Policy Task Force. This broad policy review is an ideal opportunity to build energy policies and related economic initiatives leading to new industries, new jobs, and increased energy security. The document is divided in five parts: the BC situation: trends and impacts, BC Hydro and the rush to gas, the BC gas turbine experience: conflict and controversy, gas and the changing dynamics of the BC energy market, and the clean energy path: lessons and policy recommendations. refs., 1 tab., 4 figs

Pulmonary Disease due to Mycobacterium malmoense in British Columbia

Directory of Open Access Journals (Sweden)

Mohamed S Al-Moamary

1998-01-01

Full Text Available Mycobacterium malmoense was first described in northern Europe and the United Kingdom in 1977. Since then, reports have appeared with increasing frequency. Cases have, however, rarely been reported from the United States, and, until now, none have been reported in Canada. This may reflect either true low prevalence of the disease or underdiagnosis by laboratories due to slow growth of the organism. This report describes a case of pulmonary disease caused by M malmoense in a 44-year-old man from British Columbia who was successfully treated with an 18-month course of conventional antituberculous drugs combined with a macrolide. This is the first report of this disease in British Columbia and, to our knowledge, in Canada.

Nonlinear dynamic response of an electrically actuated imperfect microbeam resonator

KAUST Repository

Ruzziconi, Laura

2013-08-04

We present a study of the dynamic behavior of a MEMS device constituted of an imperfect clamped-clamped microbeam subjected to electrostatic and electrodynamic actuation. Our objective is to develop a theoretical analysis, which is able to describe and predict all the main relevant aspects of the experimental response. Extensive experimental investigation is conducted, where the main imperfections coming from microfabrication are detected and the nonlinear dynamics are explored at increasing values of electrodynamic excitation, in a neighborhood of the first symmetric resonance. The nonlinear behavior is highlighted, which includes ranges of multistability, where the non-resonant and the resonant branch coexist, and intervals where superharmonic resonances are clearly visible. Numerical simulations are performed. Initially, two single mode reduced-order models are considered. One is generated via the Galerkin technique, and the other one via the combined use of the Ritz method and the Padé approximation. Both of them are able to provide a satisfactory agreement with the experimental data. This occurs not only at low values of electrodynamic excitation, but also at higher ones. Their computational efficiency is discussed in detail, since this is an essential aspect for systematic local and global simulations. Finally, the theoretical analysis is further improved and a two-degree-of-freedom reduced-order model is developed, which is capable also to capture the measured second symmetric superharmonic resonance. Despite the apparent simplicity, it is shown that all the proposed reduced-order models are able to describe the experimental complex nonlinear dynamics of the device accurately and properly, which validates the proposed theoretical approach. Copyright © 2013 by ASME.

1992 Columbia River Salmon Flow Measures Options Analysis/EIS : Appendices.

Energy Technology Data Exchange (ETDEWEB)

1992-01-01

This Options Analysis/Environmental Impact Statement (OA/EIS) identifies, presents effects of, and evaluates the potential options for changing instream flow levels in efforts to increase salmon populations in the lower Columbia and Snake rivers. The potential actions would be implemented during 1992 to benefit juvenile and adult salmon during migration through eight run-of-river reservoirs. The Corps of Engineers (Corps) prepared this document in cooperation with the Bonneville Power Administration and the Bureau of Reclamation. The US Fish and Wildlife Service (FWS) is a participating agency. The text and appendices of the document describe the characteristics of 10 Federal projects and one private water development project in the Columbia River drainage basin. Present and potential operation of these projects and their effects on the salmon that spawn and rear in the Columbia and Snake River System are presented. The life history, status, and response of Pacific salmon to current environmental conditions are described. The document concludes with an evaluation of the potential effects that could result from implementing proposed actions. The conclusions are based on evaluation of existing data, utilization of numerical models, and application of logical inference. This volume contains the appendices.

1992 Columbia River salmon flow measures Options Analysis/EIS: Appendices

International Nuclear Information System (INIS)

1992-01-01

This Options Analysis/Environmental Impact Statement (OA/EIS) identifies, presents effects of, and evaluates the potential options for changing instream flow levels in efforts to increase salmon populations in the lower Columbia and Snake rivers. The potential actions would be implemented during 1992 to benefit juvenile and adult salmon during migration through eight run-of-river reservoirs. The Corps of Engineers (Corps) prepared this document in cooperation with the Bonneville Power Administration and the Bureau of Reclamation. The US Fish and Wildlife Service (FWS) is a participating agency. The text and appendices of the document describe the characteristics of 10 Federal projects and one private water development project in the Columbia River drainage basin. Present and potential operation of these projects and their effects on the salmon that spawn and rear in the Columbia and Snake River System are presented. The life history, status, and response of Pacific salmon to current environmental conditions are described. The document concludes with an evaluation of the potential effects that could result from implementing proposed actions. The conclusions are based on evaluation of existing data, utilization of numerical models, and application of logical inference. This volume contains the appendices

British Columbia, Canada Tsunami Forecast Grids for MOST Model

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The British Columbia, Canada Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...

Columbia River Hatchery Reform System-Wide Report.

Energy Technology Data Exchange (ETDEWEB)

Warren, Dan [Hatchery Scientific Review Group

2009-04-16

for Puget Sound/Coastal Washington hatchery programs, followed by the development in 2005 of a suite of analytical tools to support application of the principles (all reports and tools are available at www.hatcheryreform.us). In 2005, Congress directed the National Oceanic and Atmospheric Administration-Fisheries (NOAA Fisheries) to replicate the Puget Sound and Coastal Washington Hatchery Reform Project in the Columbia River Basin. The HSRG was expanded to 14 members to include individuals with specific knowledge about the Columbia River salmon and steelhead populations. This second phase was initially envisioned as a one-year review, with emphasis on the Lower Columbia River hatchery programs. It became clear however, that the Columbia River Basin needed to be viewed as an inter-connected ecosystem in order for the review to be useful. The project scope was subsequently expanded to include the entire Basin, with funding for a second year provided by the Bonneville Power Administration (BPA) under the auspices of the Northwest Power and Conservation Council's (NPCC) Fish and Wildlife Program. The objective of the HSRG's Columbia River Basin review was to change the focus of the Columbia River hatchery system. In the past, these hatchery programs have been aimed at supplying adequate numbers of fish for harvest as mitigation primarily for hydropower development in the Basin. A new, ecosystem-based approach is founded on the idea that harvest goals are sustainable only if they are compatible with conservation goals. The challenge before the HSRG was to determine whether or not conservation and harvest goals could be met by fishery managers and, if so, how. The HSRG determined that in order to address these twin goals, both hatchery and harvest reforms are necessary. The HSRG approach represents an important change of direction in managing hatcheries in the region. It provides a clear demonstration that current hatchery programs can indeed be redirected to

The Columbia River plume as cross-shelf exporter and along-coast barrier

Science.gov (United States)

Banas, N. S.; MacCready, P.; Hickey, B. M.

2009-01-01

An intensive Lagrangian particle-tracking analysis of the July 2004 upwelling period was conducted in a hindcast model of the US Pacific Northwest coast, in order to determine the effect of the Columbia River plume on the fate of upwelled water. The model, implemented using Regional Ocean Modeling System (ROMS), includes variable wind and atmospheric forcing, variable Columbia river flow, realistic boundary conditions from Navy Coastal Ocean Model (NCOM), and 10 tidal constituents. Model skill has been demonstrated in detail elsewhere [MacCready, P., Banas, N.S., Hickey, B.M., Dever, E.P., Liu, Y., 2008. A model study of tide- and wind-induced mixing in the Columbia River estuary and plume. Continental Shelf Research, this issue, doi:10.1016/j.csr.2008.03.015]. Particles were released in the Columbia estuary, along the Washington coastal wall, and along the model's northern boundary at 48°N. Particles were tracked in three dimensions, using both velocities from ROMS and a vertical random displacement representing turbulent mixing. When 25 h of upwelling flow is looped and particles tracked for 12 d, their trajectories highlight a field of transient eddies and recirculations on scales from 5 to 50 km both north and south of the Columbia. Not all of these features are caused by plume dynamics, but the presence of the plume increases the entrainment of inner-shelf water into them. The cumulative effect of the plume's interaction with these transient features is to increase cross-shelf dispersion: 25% more water is transported laterally past the 100 m isobath when river and estuarine effects are included than when they are omitted. This cross-shelf dispersion also disrupts the southward transport of water along the inner shelf that occurs in the model when the Columbia River is omitted. This second effect—increased retention of upwelled water on the Washington shelf—may be partly responsible for the regional-scale alongcoast gradient in chlorophyll biomass

Separation of the Shuttle Columbia's external fuel tank

Science.gov (United States)

1981-01-01

Separation of the Shuttle Columbia's external fuel tank (ET), photographed by a camera in the umbilical bay. Camera was able to record the underside of the tank as the orbiter toward its earth-orbital mission and the fuel tank fell toward the earth.

Climatology of the interior Columbia River basin.

Science.gov (United States)

Sue A. Ferguson

1999-01-01

This work describes climate means and trends in each of three major ecological zones and 13 ecological reporting units in the interior Columbia River basin. Widely differing climates help define each major zone and reporting unit, the pattern of which is controlled by three competing air masses: marine, continental, and arctic. Paleoclimatic evidence and historical...

Columbia River System Operation Review : Final Environmental Impact Statement, Appendix D: Exhibits.

Energy Technology Data Exchange (ETDEWEB)

Columbia River System Operation Review (U.S.)

1995-11-01

The Columbia River and its tributaries are the primary water system in the Pacific Northwest, draining some 219,000 square miles in seven states and another 39,500 square miles in British Columbia. Beginning in the 1930`s, the Columbia River has been significantly modified by construction of 30 major dams on the river and its tributaries, along with dozens of non-Federal projects. Construction and subsequent operation of these water development projects have contributed to eight primary uses of the river system, including navigation, flood control, irrigation, electric power generation, fish migration, fish and wildlife habitat, recreation, and water supply and quality considerations. Increasing stress on the water development of the Columbia River and its tributaries has led primary Federal agencies to undertake intensive analysis and evaluation of the operation of these projects. These agencies are the U.S. Army Corps of Engineers and the Bureau of Reclamation, who operate the large Federal dams on the river, and the Bonneville Power Administration who sells the power generated at the dams. This review, termed the System Operation Review (SOR), has as its ultimate goal to define a strategy for future operation of the major Columbia River projects which effectively considers the needs of all river uses. This volume, Appendix D: Cultural resources appendix, Technical imput includes the following: Development of geomorphology based framework for cultural resources management, Dworshak Reservoir, Idaho; Impact profiles for SOR reservoirs; comments from the following Native American tribes: Burns Paiute Tribe; Coville Confederated Tribes; Confederated Tribes of the Warm Springs Indian Reservation; Confederated Tribes and bands of the Yakama Indian Nation (comments); Nez Perce Tribe; Coeur D`Alene Tribe; Spokane Tribe of Indians; The confederated Tribes of the Umatilla Indian Reservation.

LCREP catch records - Lower Columbia River Ecosystem Monitoring Project

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — 1) The purpose of this project is to document juvenile salmon habitat occurrence in the Lower Columbia River and estuary, and examine how habitat conditions...

LCREP prey data - Lower Columbia River Ecosystem Monitoring Project

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — 1) The purpose of this project is to document juvenile salmon habitat occurrence in the Lower Columbia River and estuary, and examine how habitat conditions...

LCREP growth rates - Lower Columbia River Ecosystem Monitoring Project

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — 1) The purpose of this project is to document juvenile salmon habitat occurrence in the Lower Columbia River and estuary, and examine how habitat conditions...

Columbia River ESI: SOCECON (Socioeconomic Resource Points and Lines)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains vector points and lines representing human-use resource data for Columbia River. In the data set, vector points represent aquaculture sites,...

British Columbia capital regional district 100% smokefree bylaw: a successful public health campaign despite industry opposition.

Science.gov (United States)

Drope, J; Glantz, S

2003-09-01

To describe how the British Columbia Capital Regional District successfully passed, implemented, and enforced a 100% smokefree bylaw in all public places, including restaurants and bars, despite an aggressive campaign by the tobacco industry (acting through the hospitality industry) to stop it. Information was obtained from news reports, internal tobacco industry documents, reports, public documents, and interviews with key players. Tobacco industry documents were accessed between February and April 2002. This project was approved by the University of California San Francisco committee on human research. As in the USA and elsewhere in the world, the tobacco industry in British Columbia, Canada, recruited and created hospitality associations to fight against the district smokefree bylaw. They used the classic industry rhetoric of individual rights and freedoms, economic devastation, and ventilation as a solution. Public health authorities were able to counter industry strategies with a strong education campaign, well written bylaws, and persistent enforcement. It is possible to overcome serious opposition orchestrated by the tobacco industry and develop and implement a 100% smokefree bylaw in Canada. Doing so requires attention to detail in drafting the bylaw, as well as a public education campaign on the health dangers of secondhand smoke and active enforcement to overcome organised resistance to the bylaw. Jurisdictions considering smokefree bylaws should anticipate this opposition when developing and implementing their bylaws.

Introduction of the Space Shuttle Columbia Accident, Investigation Details, Findings and Crew Survival Investigation Report

Science.gov (United States)

Chandler, Michael

2010-01-01

As the Space Shuttle Program comes to an end, it is important that the lessons learned from the Columbia accident be captured and understood by those who will be developing future aerospace programs and supporting current programs. Aeromedical lessons learned from the Accident were presented at AsMA in 2005. This Panel will update that information, closeout the lessons learned, provide additional information on the accident and provide suggestions for the future. To set the stage, an overview of the accident is required. The Space Shuttle Columbia was returning to Earth with a crew of seven astronauts on 1Feb, 2003. It disintegrated along a track extending from California to Louisiana and observers along part of the track filmed the breakup of Columbia. Debris was recovered from Littlefield, Texas to Fort Polk, Louisiana, along a 567 statute mile track; the largest ever recorded debris field. The Columbia Accident Investigation Board (CAIB) concluded its investigation in August 2003, and released their findings in a report published in February 2004. NASA recognized the importance of capturing the lessons learned from the loss of Columbia and her crew and the Space Shuttle Program managers commissioned the Spacecraft Crew Survival Integrated Investigation Team (SCSIIT) to accomplish this. Their task was to perform a comprehensive analysis of the accident, focusing on factors and events affecting crew survival, and to develop recommendations for improving crew survival, including the design features, equipment, training and procedures intended to protect the crew. NASA released the Columbia Crew Survival Investigation Report in December 2008. Key personnel have been assembled to give you an overview of the Space Shuttle Columbia accident, the medical response, the medico-legal issues, the SCSIIT findings and recommendations and future NASA flight surgeon spacecraft accident response training. Educational Objectives: Set the stage for the Panel to address the

Preliminary subsurface hydrologic considerations: Columbia River Plateau Physiographic Province. Assessment of effectiveness of geologic isolation systems

International Nuclear Information System (INIS)

Veatch, M.D.

1980-04-01

This report contains a discussion of the hydrologic conditions of the Columbia River Plateau physiographic province. The Columbia River Plateau is underlain by a thick basalt sequence. The Columbia River basalt sequence contains both basalt flows and sedimentary interbeds. These sedimentary interbeds, which are layers of sedimentary rock between lava flows, are the main aquifer zones in the basalt sequence. Permeable interflow zones, involving the permeable top and/or rubble bottom of a flow, are also water-transmitting zones. A number of stratigraphic units are present in the Pasco Basin, which is in the central part of the Columbia River Plateau. At a conceptual level, the stratigraphic sequence from the surface downward can be separated into four hydrostratigraphic systems. These are: (1) the unsaturated zone, (2) the unconfined aquifer, (3) the uppermost confined aquifers, and (4) the lower Yakima basalt hydrologic sequence. A conceptual layered earth model (LEM) has been developed. The LEM represents the major types of porous media (LEM units) that may be encountered at a number of places on the Columbia Plateau, and specifically in the Pasco Basin. The conceptual LEM is not representative of the actual three-dimensional hydrostratigraphic sequence and hydrologic conditions existing at any specific site within the Columbia Plateau physiographic province. However, the LEM may be useful for gaining a better understanding of how the hydrologic regime may change as a result of disruptive events that may interact with a waste repository in geologic media

Radionuclide concentrations in white sturgeon from the Columbia River. Revision 1

Energy Technology Data Exchange (ETDEWEB)

Dauble, D.D.; Price, K.R.; Poston, T.M.

1993-11-01

The objectives of this study were to (1) review and summarize historical data on radionuclide concentrations in white sturgeon from the Columbia River, (2) determine present-day radionuclide tissue burdens from different locations in the Columbia River, and (3) compare historical data with current data. We first reviewed and summarized the historical literature on radionuclide concentrations in white sturgeon from the Hanford Reach. Field studies were then conducted to evaluate the relationship among sample locations, age/length of white sturgeon, and present radionuclide tissue burdens. Results and comparisons are discussed in the remainder of this report.

Invertebrates of the Columbia River basin assessment area.

Science.gov (United States)

Christine G. Niwa; Roger E. Sandquist; Rod Crawford; et al.

2001-01-01

A general background on functional groups of invertebrates in the Columbia River basin and how they affect sustainability and productivity of their ecological communities is presented. The functional groups include detritivores, predators, pollinators, and grassland and forest herbivores. Invertebrate biodiversity and species of conservation interest are discussed....

Hydrogeologic controls on ground-water and contaminant discharge to the Columbia River near the Hanford Townsite

International Nuclear Information System (INIS)

Luttrell, S.P.; Newcomer, D.R.; Teel, S.S.; Vermeul, V.R.

1992-11-01

The purpose of this study is to quantify ground-water and contaminant discharge to the Columbia River in the Hanford Townsite vicinity. The primary objectives of the work are to: describe the hydrogeologic setting and controls on ground-water movement and contaminant discharge to the Columbia River; understand the river/aquifer relationship and its effects on contaminant discharge to the Columbia River; quantify the ground-water and contaminant mass discharge to the Columbia River; and provide data that may be useful for a three-dimensional model of ground-water flow and contaminant transport in the Hanford Townsite study area. The majority of ground-water contamination occurs within the unconfined aquifer; therefore, ground-water and contaminant discharge from the unconfined aquifer is the emphasis of this study. The period of study is primarily from June 1990 through March 1992