Sample records for coloriometric technology rapidly

  1. Composites by rapid prototyping technology

    CSIR Research Space (South Africa)

    Kumar, S


    Full Text Available powder is a fiber, problems of manufacturing occur. The method has also been used to make Metal Matrix Composite (MMC), e.g Fe and graphite [17], WC-Co [18,19], WC-Co and Cu [20,21], Fe, Ni and TiC [22] etc and Ceramic Matrix Composite (CMC) e.g. Si... of various materials used. Key words: : Rapid Prototyping (RP), Laser, Composites 1 Introduction Rapid Prototyping (RP) initially focussed on polymers. These were later re- placed/supplemented by ceramics, metals and composites. Composites are used in RP...

  2. Polyjet technology applications for rapid tooling

    Directory of Open Access Journals (Sweden)

    Udroiu Razvan


    Full Text Available Polymer Jetting (PolyJet has proved to be one of the most accurate additive manufacturing technologies, in order to manufacture rapid tools. Rapid Tooling (RT is different from conventional tooling as follow: manufacturing time is shorter, the cost is much less, but the tool life is shorter and tolerances are wider. The purpose of this paper is to make a comparative study between the soft tools (silicon moulds and hard tools (acrylic thermoplastic moulds based on the Polymer Jetting technology. Thus, two types of moulds have been made in order to manufacture a test part. Reaction injection moulding (RIM and casting techniques were used to fill these moulds with resins that simulate the plastic injection materials. Rapid tooling applications, such as indirect tooling and direct tooling, based on PolyJet technology were experimentally investigated.

  3. Utilizing Information Technology to Facilitate Rapid Acquisition (United States)


    ordering systems to facilitate streamlined commercial item acquisitions that reap the benefits of improved efficiency, reduced overall costs, and...PAGES 109 14. SUBJECT TERMS Rapid Acquisition, eCommerce , eProcurement, Information Technology, Contracting, Global Information Network...streamlined commercial item acquisitions that reap the benefits of improved efficiency, reduced overall costs, and timeliness. This thesis

  4. Rapid Prototyping: Technologies, Materials and Advances

    Directory of Open Access Journals (Sweden)

    Dudek P.


    Full Text Available In the context of product development, the term rapid prototyping (RP is widely used to describe technologies which create physical prototypes directly from digital data. Recently, this technology has become one of the fastest-growing methods of manufacturing parts. The paper provides brief notes on the creation of composites using RP methods, such as stereolithography, selective laser sintering or melting, laminated object modelling, fused deposition modelling or three-dimensional printing. The emphasis of this work is on the methodology of composite fabrication and the variety of materials used in these technologies.

  5. Rapid thermal processing science and technology

    CERN Document Server

    Fair, Richard B


    This is the first definitive book on rapid thermal processing (RTP), an essential namufacturing technology for single-wafer processing in highly controlled environments. Written and edited by nine experts in the field, this book covers a range of topics for academics and engineers alike, moving from basic theory to advanced technology for wafer manufacturing. The book also provides new information on the suitability or RTP for thin film deposition, junction formation, silicides, epitaxy, and in situ processing. Complete discussions on equipment designs and comparisons between RTP and other

  6. Development and tendency of rapid prototyping technology (United States)

    Yan, Yongnian; Hong, Guodong


    The definition of the rapid prototyping is given in this paper. Various RP processes, which build the prototypes with 2.5 or 3 dimensional layers, are introduced. The relative techniques of RP and the differences between RP technique and CNC manufacturing are analyzed. The paper discusses the RP's applied fields and methods and presents the RP development in the world. According to the idea that requirements determine the developing, the RP's tendency is discussed.

  7. ETV Tech Brief: Rapid Fungi and Bacteria Detection Technologies (United States)

    Technical brief that summarizes the results for Mycometer, Inc. Mycometer®-test and Bactiquant®-test, which are rapid detection technologies for fungi and bacteria. The brief summarizes the results of the verification report and statement.

  8. Medical Information & Technology: Rapidly Expanding Vast Horizons (United States)

    Sahni, Anil K.


    During ÑMedical Council Of India?, Platinum Jubilee Year (1933-2008) Celebrations, In Year 2008, Several Scientific Meeting/Seminar/Symposium, On Various Topics Of Contemporary Importance And Relevance In The Field Of ÑMedical Education And Ethics?, Were Organized, By Different Medical Colleges At Various Local, State, National Levels. The Present Discussion, Is An Comprehensive Summary Of Various Different Aspects of ìMedical Information Communication Technologyî, Especially UseFul For The Audience Stratum Group Of Those Amateur Medical & Paramedical Staff, With No Previous Work Experience Knowledge Of Computronics Applications. Outlining The, i.Administration Applications: Medical Records Etc, ii. Clinical Applications: Pros pective Scope Of TeleMedicine Applicabilities Etc iii. Other Applications: Efforts To Augment Improvement Of Medical Education, Medical Presentations, Medical Education And Research Etc. ÑMedical Trancription? & Related Recent Study Fields e.g ÑModern Pharmaceuticals?,ÑBio-Engineering?, ÑBio-Mechanics?, ÑBio-Technology? Etc., Along With Important Aspects Of Computers-General Considerations, Computer Ergonomics Assembled To Summarize, The AwareNess Regarding Basic Fundamentals Of Medical Computronics & Its Practically SuccessFul Utilities.

  9. Rapid Airfield Damage Recovery: Deployable Saw Technology Evaluation (United States)


    ER D C/ G SL T R- 17 -2 9 Rapid Airfield Damage Recovery: Deployable Saw Technology Evaluation G eo te ch ni ca l a nd S tr uc tu re s...Deployable Saw Technology Evaluation Haley P. Bell and Jay Rowland Geotechnical and Structures Laboratory U.S. Army Engineer Research and Development...evaluation of selected saw technologies , tools, and methodologies for improving the efficiency of sawing around damaged pavement associated with crater

  10. Rapid single flux quantum logic in high temperature superconductor technology

    NARCIS (Netherlands)

    Shunmugavel, K.


    A Josephson junction is the basic element of rapid single flux quantum logic (RSFQ) circuits. A high operating speed and low power consumption are the main advantages of RSFQ logic over semiconductor electronic circuits. To realize complex RSFQ circuits in HTS technology one needs a reproducible

  11. Promoting Rapid Learning in the Histology Laboratory by Integrating Technology (United States)

    Shields, Vonnie


    This paper describes the results of incorporating technology in the histology laboratory by using high-resolution video-imaging equipment (VIE). The study sought to determine if (1) the VIE would allow students to more easily and rapidly find histological structures over more conventional methods, and (2) if they could find the structures with the…

  12. Rapid prototyping technology and its application in bone tissue engineering. (United States)

    Yuan, Bo; Zhou, Sheng-Yuan; Chen, Xiong-Sheng

    Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.


    Directory of Open Access Journals (Sweden)

    Tirthendu Bagchi


    Full Text Available Current paper has the purpose to analyze the statement by Drucker (1985 that rapid changes in today’s society, technology, and economy in general are simultaneously a great threat to public-service institutions and even greater opportunity. The statement by Drucker will be analyzed  particularly with context of post offices that what are they going through these days or have gone through. Finally, some recommendations will be made for USPS based on the findings of the analysis..

  14. New technologies for the rapid diagnosis of neonatal sepsis. (United States)

    Srinivasan, Lakshmi; Harris, Mary C


    To present recent literature on novel diagnostic tests in neonatal sepsis. Our review of technologies for the rapid diagnosis of neonatal sepsis includes new adaptations of time-honored tests as well as advances on the forefront of medicine. A recent study demonstrates that age-specific likelihood values for the complete blood count may determine risk of infection. Systematic reviews of procalcitonin, mannose-binding lectin and molecular amplification techniques provide summary data from accumulated literature on these tests. Proteomics-based and genomics-based exploratory researches suggest new combinations of markers as important signals of sepsis, whereas damage-associated molecular patterns, a class of inflammatory mediators now viewed as key players in the inflammatory cascade, may be useful predictors of disease progression and severity. Heart rate variability monitoring has also been suggested as a way to reduce mortality in very low birth weight neonates. Finally, molecular techniques are rapidly advancing in sophistication and may soon be useful as adjunctive bacterial identification tests. Several novel tests show promise in the early detection of sepsis. Highlights include new combinations of biomarkers unearthed by proteomics-based research and identification of sepsis based on gene expression profiling. Future research should focus on validation of these findings and further refinement of molecular techniques.

  15. Market Channels of Technology Startups that Internationalize Rapidly from Inception

    Directory of Open Access Journals (Sweden)

    Simar Yoos


    Full Text Available The study of technology startups that internationalize rapidly from inception has increased in recent years. However, little is known about their channels to market. This article addresses a gap in the "born global" literature by examining the channels used by six startups that internationalized rapidly from inception as well as the programs they used to support their channel partners and customers. The six startups examined combined the use of the Internet with: i a relationship with a multi-national, ii distributors, iii re-sellers, or iv a direct sales force. They also delivered programs to support partners and customers that focused on communications, alliance and network development, education, marketing and promotion, and financial incentives. This article informs entrepreneurs who need to design go-to-market channels to exploit global opportunities about decisions made by other entrepreneurs who launched born-global companies. Normative rules and practitioner-oriented approaches are needed to help entrepreneurs explain and apply the results presented in this article.

  16. Missile signal processing common computer architecture for rapid technology upgrade (United States)

    Rabinkin, Daniel V.; Rutledge, Edward; Monticciolo, Paul


    Interceptor missiles process IR images to locate an intended target and guide the interceptor towards it. Signal processing requirements have increased as the sensor bandwidth increases and interceptors operate against more sophisticated targets. A typical interceptor signal processing chain is comprised of two parts. Front-end video processing operates on all pixels of the image and performs such operations as non-uniformity correction (NUC), image stabilization, frame integration and detection. Back-end target processing, which tracks and classifies targets detected in the image, performs such algorithms as Kalman tracking, spectral feature extraction and target discrimination. In the past, video processing was implemented using ASIC components or FPGAs because computation requirements exceeded the throughput of general-purpose processors. Target processing was performed using hybrid architectures that included ASICs, DSPs and general-purpose processors. The resulting systems tended to be function-specific, and required custom software development. They were developed using non-integrated toolsets and test equipment was developed along with the processor platform. The lifespan of a system utilizing the signal processing platform often spans decades, while the specialized nature of processor hardware and software makes it difficult and costly to upgrade. As a result, the signal processing systems often run on outdated technology, algorithms are difficult to update, and system effectiveness is impaired by the inability to rapidly respond to new threats. A new design approach is made possible three developments; Moore's Law - driven improvement in computational throughput; a newly introduced vector computing capability in general purpose processors; and a modern set of open interface software standards. Today's multiprocessor commercial-off-the-shelf (COTS) platforms have sufficient throughput to support interceptor signal processing requirements. This application

  17. Emerging technologies for rapid identification of bloodstream pathogens. (United States)

    Kothari, Atul; Morgan, Margie; Haake, David A


    Technologies for rapid microbial identification are poised to revolutionize clinical microbiology and enable informed decision making for patients with life-threatening bloodstream infections. Species identification of microorganisms in positive blood cultures can be performed in minutes using commercial fluorescence in situ hybridization tests or mass spectroscopy. Microorganisms in positive blood cultures can also be identified within 1-2.5 hours using automated polymerase chain reaction-based systems that can also detect selected antibiotic resistance markers, such as methicillin resistance. When combined with antibiotic stewardship programs, these approaches improve clinical outcomes and reduce healthcare expenditures. Tests for direct detection in whole blood samples are highly desirable because of their potential to identify bloodstream pathogens without waiting 1-2 days for blood cultures to become positive. However, results for pathogen detection in whole blood do not overlap with those of conventional blood culture techniques and we are still learning how best to use these approaches. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail:

  18. Additive manufacturing technologies: 3D printing, rapid prototyping, and direct digital manufacturing

    National Research Council Canada - National Science Library

    Gibson, Ian; Rosen, David; Stucker, B


    .... This book provides a comprehensive overview of rapid prototyping technologies as well as support technologies such as software systems, vacuum casting, investment casting, plating, infiltration and other systems. This book also...

  19. Studying the Technology of Creating Cortical Electrode Instruments using the Rapid Prototyping Technology

    Directory of Open Access Journals (Sweden)

    Ablyaz T. R.


    Full Text Available This paper shows the results of studying the technology of manufacturing cortical electrode-instruments (EI with the use of indirect methods of the Rapid Prototyping technology. Functional EI prototypes were made by layered synthesis of the photopolymer material with the use of the stereolithography technology (SLA - Stereo Lithography Apparatus. The article is focused on two methods of indirect EI manufacturing. One of the EI prototypes was used for making a molded wax model for hot investment casting, followed by applying copper coating. The second prototype was used for applying copper plating to a prepared current-conductive layer. As a result of EDMing a steel workpiece, both EIs reached the desired depth, which is 1 mm. The copper plating applied to the EI preserves its integrity. Through the use of the casting technology, there is a possibility to cut the economic costs by 35%. Using a prototype with preliminarily applied conductive coating makes it possible to make geometrically-complex EIs.

  20. The reasons for the rapid development of human technologies


    Macfarlane, Alan


    While playing with a two-year-old girl in Australia, Alan Macfarlane explains one reason for the rapid development of humans, namely their curiosity and desire to experiment and to imagine and make new things.

  1. Advanced powder metallurgy aluminum alloys via rapid solidification technology (United States)

    Ray, R.


    Aluminum alloys containing 10 to 11.5 wt. pct. of iron and 1.5 to 3 wt. pct. of chromium using the technique of rapid solidification powder metallurgy were studied. Alloys were prepared as thin ribbons (.002 inch thick) rapidly solidified at uniform rate of 10(6) C/second by the melt spinning process. The melt spun ribbons were pulverized into powders (-60 to 400 mesh) by a rotating hammer mill. The powders were consolidated by hot extrusion at a high reduction ratio of 50:1. The powder extrusion temperature was varied to determine the range of desirable processing conditions necessary to yield useful properties. Powders and consolidated alloys were characterized by SEM and optical metallography. The consolidated alloys were evaluated for (1) thermal stability, (2) tensile properties in the range, room temperature to 450 F, and (3) notch toughness in the range, room temperature to 450 F.

  2. Smartphone Technology and Apps: Rapidly Changing Health Promotion (United States)

    Kratzke, Cynthia; Cox, Carolyn


    Despite the increased availability of smartphones and health applications (apps), little is known about smartphone technology and apps for implementation in health promotion practice. Smartphones are mobile devices with capabilities for e-mail, text messaging, video viewing, and wireless Internet access. It is essential for health promotion…

  3. Rapid Response to Decision Making for Complex Issues - How Technologies of Cooperation Can Help

    National Research Council Canada - National Science Library

    Saveri, Andrea; Vian, Kathi; Rheingold, Howard


    .... A new capacity for rapid, ad hoc, and distributed decision making is emerging from the intersection of technologies of cooperation and new knowledge about the nature of cooperation and cooperative strategies...

  4. Additive manufacturing technologies 3D printing, rapid prototyping, and direct digital manufacturing

    CERN Document Server

    Gibson, Ian; Stucker, Brent


    This book covers in detail the various aspects of joining materials to form parts. A conceptual overview of rapid prototyping and layered manufacturing is given,  beginning with the fundamentals so that readers can get up to speed quickly. Unusual and emerging applications such as micro-scale manufacturing, medical applications, aerospace, and rapid manufacturing are also discussed. This book provides a comprehensive overview of rapid prototyping technologies as well as support technologies such as software systems, vacuum casting, investment casting, plating, infiltration and other systems. This book also: Reflects recent developments and trends and adheres to the ASTM, SI, and other standards Includes chapters on automotive technology, aerospace technology and low-cost AM technologies Provides a broad range of technical questions to ensure comprehensive understanding of the concepts covered  

  5. Evidence-based medicine in rapidly changing technologies

    DEFF Research Database (Denmark)

    Schroeder, T V


    Evidence-based medicine (EBM) is not a randomised controlled trial (RCT), but EBM seeks to apply evidence gained from scientific methods - which could be RCT - to daily medical practice. Any surgical treatment reflects a certain development technically as well as skills based. The procedure may....... On the other hand, if started too late there is a chance that data may be lost because the technology has already been introduced into the daily clinics and physicians may be unwilling to recruit patients. Or the opposite, that the technique may have been rejected without a proper trial. In this situation...... it has been suggested to perform a so called tracker trial. In such trials protocols are more flexible without prefixed sample size and will require repeated interim analyses. Often, it will be relevant to supplement the clinical trials with data from large clinical databases - in particular when long...

  6. [Effects and influential factors of rapid prototyping technology in dental restorations]. (United States)

    Pan, Qiao-Ling; Yuan, Jia-Kan


    To explore the effects and influential factors of rapid prototyping technology in dental restorations. From May 2013 to November 2014 in our hospital, 120 patients were divided into experimental group and conventional group. Patients in the experimental group were treated by rapid prototyping technology, while patients in the conventional group were treated by routine methods. The effects of the two groups were compared using SPSS 17.0 software package. The effective rate of the experimental group was significantly higher than that of the conventional group (P<0.05). Complications in the experimental group were significantly lower than those in the conventional group (P<0.05). Rapid prototyping technology can be used in the treatment of patients with dentition defects with satisfactory results and fewer adverse reactions.

  7. [Application status of rapid prototyping technology in artificial bone based on reverse engineering]. (United States)

    Fang, Ao; Zheng, Min; Fan, Ding


    Artificial bone replacement has made an important contribution to safeguard human health and improve the quality of life. The application requirements of rapid prototyping technology based on reverse engineering in individualized artificial bone with individual differences are particularly urgent. This paper reviewed the current research and applications of rapid prototyping and reverse engineering in artificial bone. The research developments and the outlook of bone kinematics and dynamics simulation are also introduced.

  8. Low-Cost Inkjet Printing Technology for the Rapid Prototyping of Transducers (United States)

    Andò, Bruno; Baglio, Salvatore; Bulsara, Adi R.; Emery, Teresa; Marletta, Vincenzo; Pistorio, Antonio


    Recently, there has been an upsurge in efforts dedicated to developing low-cost flexible electronics by exploiting innovative materials and direct printing technologies. This interest is motivated by the need for low-cost mass-production, shapeable, and disposable devices, and the rapid prototyping of electronics and sensors. This review, following a short overview of main printing processes, reports examples of the development of flexible transducers through low-cost inkjet printing technology. PMID:28368318

  9. Low-Cost Inkjet Printing Technology for the Rapid Prototyping of Transducers. (United States)

    Andò, Bruno; Baglio, Salvatore; Bulsara, Adi R; Emery, Teresa; Marletta, Vincenzo; Pistorio, Antonio


    Recently, there has been an upsurge in efforts dedicated to developing low-cost flexible electronics by exploiting innovative materials and direct printing technologies. This interest is motivated by the need for low-cost mass-production, shapeable, and disposable devices, and the rapid prototyping of electronics and sensors. This review, following a short overview of main printing processes, reports examples of the development of flexible transducers through low-cost inkjet printing technology.

  10. Rapid DNA technologies at the crime scene : ‘CSI’ fiction matching reality

    NARCIS (Netherlands)

    Mapes, A.A.


    This thesis describes how mobile Rapid DNA analysis may be implemented as a potential effective tool in modern day law enforcement. It is expected that this technology will affect the role of the forensic institutes and the tasks of professionals in the Criminal Justice System (CJS). The research in

  11. Rapid and real-time detection technologies for emerging viruses of ...

    Indian Academy of Sciences (India)


    Oct 17, 2008 ... The development of technologies with rapid and sensitive detection capabilities and increased throughput have become crucial for responding to greater number threats posed by emerging and re-emerging viruses in the recent past. The conventional identification methods require time-consuming culturing ...

  12. The application of Rapid Manufacturing technologies in the spare parts industry


    S. Hasan; Rennie, A. E. W.


    The advancement of Rapid Manufacturing (RM) has ushered the possibility of realising complex designs. This paper identifies the potential of possible applications of RM in the spare parts industry. It further underlines the need for a fully functional RM supply chain before proposing an e-business enabled business model for RM technologies.

  13. Rapid Determination of Optimal Conditions in a Continuous Flow Reactor Using Process Analytical Technology

    Directory of Open Access Journals (Sweden)

    Michael F. Roberto


    Full Text Available Continuous flow reactors (CFRs are an emerging technology that offer several advantages over traditional batch synthesis methods, including more efficient mixing schemes, rapid heat transfer, and increased user safety. Of particular interest to the specialty chemical and pharmaceutical manufacturing industries is the significantly improved reliability and product reproducibility over time. CFR reproducibility can be attributed to the reactors achieving and maintaining a steady state once all physical and chemical conditions have stabilized. This work describes the implementation of a smart CFR with univariate physical and multivariate chemical monitoring that allows for rapid determination of steady state, requiring less than one minute. Additionally, the use of process analytical technology further enabled a significant reduction in the time and cost associated with offline validation methods. The technology implemented for this study is chemistry and hardware agnostic, making this approach a viable means of optimizing the conditions of any CFR.

  14. What Technology Startups Must Get Right to Globalize Early and Rapidly

    Directory of Open Access Journals (Sweden)

    Tony Bailetti


    Full Text Available Upon or shortly after inception, growth-oriented technology startups must operate in a market that is global. Management teams and investors of technology startups can benefit from approaches and models that can help them operate in a global market early and rapidly. How well a technology startup addresses the realities of globalization will determine its success. A better understanding of what management teams and investors of technology startups must get right to globalize their startups is needed. This article is an attempt to meet this need. In this article, lessons that have been extracted from six literature streams and from information on 21 startups founded in 12 countries are used to identify the six elements that a startup must get right to globalize early and rapidly. These six elements are: i Problem scope, ii Stakeholders’ commitments, iii Collaborative entrepreneurship, iv Relational capital, v Legitimacy, and vi Global capability. The main contribution of this article is that it throws the spotlight on the need to develop prescriptive rules and practitioner-oriented models that can help a technology startup operate globally from an early stage.

  15. The Information Technology Program Manager’s Dilemma: Rapidly Evolving Technology and Stagnant Processes (United States)


    information technology systems. The current DoDI 5000.02 leaves IT project and program managers wondering how the current process applies to them, as the guidance is fairly rigid and does not allow for the flexibility required to appropriately manage IT programs. Until very recently, in comparison to the development of a traditional weapons system, IT programs seemed to have been viewed as a utility or service instead of a critical component to national security. Perhaps that is because data passing through cables cannot be observed with the naked senses and therefore an

  16. Applications of the Rapid Prototyping Technology to Manufacture the Pelton Runners

    Directory of Open Access Journals (Sweden)

    Dorian Nedelcu


    Full Text Available The paper presents an application of the Rapid Prototyping technology using Objet Desktop 3D Printer to manufacture two Pelton runners that are destined for experimental measurements on a Pelton microturbine. The runners are different by bucket’s number and the bucket’s geometry of the second runner is similar with those of the first runner, but scaled in all directions with the bucket’s numbers ratio.

  17. [Mandibular-driven simultaneous maxillo-mandibular distraction for hemifacial microsomia with rapid prototyping technology]. (United States)

    Gao, Quan-Wen; Song, Hui-Feng; Xu, Ming-Huo; Liu, Chun-Ming; Chai, Jia-Ke


    To explore the clinical application of mandibular-driven simultaneous maxillo-mandihular distraction to correct hemifacial microsomia with rapid prototyping technology. The patient' s skull resin model was manufactured with rapid prototyping technology. The osteotomy was designed on skull resin model. According to the preoperative design, the patients underwent Le Fort I osteotomy and mandibular ramus osteotomy. The internal mandible distractor was embedded onto the osteotomy position. The occlusal titanium pin was implanted. Distraction were carried out by mandibular-driven simultaneous maxillo-mandihular distraction 5 days after operation. The distraction in five patients was complete as designed. No infection and dysosteogenesis happened. The longest distance of distraction was 28 mm, and the shortest distance was 16 mm. The facial asymmetry deformity was significantly improved at the end of distraction. The ocelusal plane of patients obviously improved. Rapid prototyping technology is helpful to design precisely osteotomy before operation. Mandibular-driven simultaneous maxillo-mandibular distraction can correct hemifacial microsomia. It is worth to clinical application.

  18. Mobile Technology in the Perioperative Arena: Rapid Evolution and Future Disruption. (United States)

    Rothman, Brian S; Gupta, Rajnish K; McEvoy, Matthew D


    Throughout the history of medicine, physicians have relied upon disruptive innovations and technologies to improve the quality of care delivered, patient outcomes, and patient satisfaction. The implementation of mobile technology in health care is quickly becoming the next disruptive technology. We first review the history of mobile technology over the past 3 decades, discuss the impact of hardware and software, explore the rapid expansion of applications (apps), and evaluate the adoption of mobile technology in health care. Next, we discuss how technology serves as the vehicle that can transform traditional didactic learning into one that adapts to the learning behavior of the student by using concepts such as the flipped classroom, just-in-time learning, social media, and Web 2.0/3.0. The focus in this modern education paradigm is shifting from teacher-centric to learner-centric, including providers and patients, and is being delivered as context-sensitive, or semantic, learning. Finally, we present the methods by which connected health systems via mobile devices increase information collection and analysis from patients in both clinical care and research environments. This enhanced patient and provider connection has demonstrated benefits including reducing unnecessary hospital readmissions, improved perioperative health maintenance coordination, and improved care in remote and underserved areas. A significant portion of the future of health care, and specifically perioperative medicine, revolves around mobile technology, nimble learners, patient-specific information and decision-making, and continuous connectivity between patients and health care systems. As such, an understanding of developing or evaluating mobile technology likely will be important for anesthesiologists, particularly with an ever-expanding scope of practice in perioperative medicine.

  19. App Factory: A flexible approach to rehabilitation engineering in an era of rapid technology advancement. (United States)

    Jones, Michael; Mueller, James; Morris, John


    This article describes a flexible and effective approach to research and development in an era of rapid technological advancement. The approach relies on secondary dispersal of grant funds to commercial developers through a competitive selection process. This "App Factory" model balances the practical reliance on multi-year funding needed to sustain a rehabilitation engineering research center (RERC), with the need for agility and adaptability of development efforts undertaken in a rapidly changing technology environment. This approach also allows us to take advantage of technical expertise needed to accomplish a particular development task, and provides incentives to deliver successful products in a cost-effective manner. In this article, we describe the App Factory structure, process, and results achieved to date; and we discuss the lessons learned and the potential relevance of this approach for other grant-funded research and development efforts. Data presented on the direct costs and number of downloads of the 16 app development projects funded in the App Factory's first 3 years show that it can be an effective means for supporting focused, short-term assistive technology development projects.

  20. Design and manufacturing of ear prosthesis by means of rapid prototyping technology. (United States)

    De Crescenzio, F; Fantini, M; Ciocca, L; Persiani, F; Scotti, R


    In this paper, the complete procedure to design and construct reusable moulds for implant-based ear prosthesis and manufacture substructures by means of a computer aided design-computer aided manufacturing (CAD-CAM) procedure and rapid prototyping (RP) technology is presented. The scan of the healthy ear, the virtual superimposition of its mirrored image on to the defective side, and the rapid manufacturing of the substructure and of the mould eliminate several steps of traditional procedures (wax, stone, try-in). Moreover, the precise design and customization of the substructure is presented, with the original and engineered shape for the retention of the silicone. The time and cost saving results of this protocol are presented together with a discussion of the main design features that make the prosthesis a stable and reproducible system to improve rehabilitation of patients with auricular defects or absence.

  1. New technologies applied to surgical processes: Virtual Reality and rapid prototyping. (United States)

    Suárez-Mejías, Cristina; Gomez-Ciriza, Gorka; Valverde, Israel; Parra Calderón, Carlos; Gómez-Cía, Tomás


    AYRA is software of virtual reality for training, planning and optimizing surgical procedures. AYRA was developed under a research, development and innovation project financed by the Andalusian Ministry of Health, called VirSSPA. Nowadays AYRA has been successfully used in more than 1160 real cases and after proving its efficiency it has been introduced in the clinical practice at the Virgen del Rocío University Hospital . Furthermore, AYRA allows generating physical 3D biomodels using rapid prototyping technology. They are used for surgical planning support, intraoperative reference or defect reconstruction. In this paper, some of these tools and some real cases are presented.

  2. Understanding rapid internationalization of new low-technology ventures from emerging economies

    DEFF Research Database (Denmark)

    Turcan, Romeo V.


    This theory-building study makes an attempt to advance the field of international entrepreneurship that is (i) fragmented and suffers from theoretical paucity, as well as from coverage bias by focusing mostly on high-technology international new ventures from developed economies and (ii) that needs...... to borrow more actively from other disciplines in order for the international entrepreneurship theory to emerge. In this endeavour, the study draws from the institutional theory in order to explore the process of rapid internationalization of new ventures from emerging economies....

  3. Rapid and accurate intraoperative pathological diagnosis by artificial intelligence with deep learning technology. (United States)

    Zhang, Jing; Song, Yanlin; Xia, Fan; Zhu, Chenjing; Zhang, Yingying; Song, Wenpeng; Xu, Jianguo; Ma, Xuelei


    Frozen section is widely used for intraoperative pathological diagnosis (IOPD), which is essential for intraoperative decision making. However, frozen section suffers from some drawbacks, such as time consuming and high misdiagnosis rate. Recently, artificial intelligence (AI) with deep learning technology has shown bright future in medicine. We hypothesize that AI with deep learning technology could help IOPD, with a computer trained by a dataset of intraoperative lesion images. Evidences supporting our hypothesis included the successful use of AI with deep learning technology in diagnosing skin cancer, and the developed method of deep-learning algorithm. Large size of the training dataset is critical to increase the diagnostic accuracy. The performance of the trained machine could be tested by new images before clinical use. Real-time diagnosis, easy to use and potential high accuracy were the advantages of AI for IOPD. In sum, AI with deep learning technology is a promising method to help rapid and accurate IOPD. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Old knowledge and new technologies allow rapid development of model organisms. (United States)

    Cook, Charles E; Chenevert, Janet; Larsson, Tomas A; Arendt, Detlev; Houliston, Evelyn; Lénárt, Péter


    Until recently the set of "model" species used commonly for cell biology was limited to a small number of well-understood organisms, and developing a new model was prohibitively expensive or time-consuming. With the current rapid advances in technology, in particular low-cost high-throughput sequencing, it is now possible to develop molecular resources fairly rapidly. Wider sampling of biological diversity can only accelerate progress in addressing cellular mechanisms and shed light on how they are adapted to varied physiological contexts. Here we illustrate how historical knowledge and new technologies can reveal the potential of nonconventional organisms, and we suggest guidelines for selecting new experimental models. We also present examples of nonstandard marine metazoan model species that have made important contributions to our understanding of biological processes. © 2016 Cook et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (

  5. Study on rapid bio-drying technology of cow dung with CaO2 (United States)

    Chen, Xiaotian; Qu, Guangfei; Liu, Shugen; Xie, Ruosong; He, Yanhua


    Effect of CaO2 on cow dung rapid bio-drying technology was researched. A static aerobic composting system was applied to this experiment which combining natural ventilation with Turing in the process of composting. The physical characteristics of cow dung was observed and the compost temperature, moisture content, organic matter, total nitrogen, total phosphorus, potassium content was determined which in order to study the effect of CaO2 on rapid drying of cattle in the compost. In the initial stage of compost, adding CaO2 groups compared with the control group, the temperature rise faster, 4-6 days in advance to the thermophilic phase; at the end of composting, the CaO2 composition and moisture content decreased significantly to below 30%. The addition of CaO2 in fertilizer was shorten the composting time, extend the thermophilic phase, to provide sufficient oxygen meeting the growth needs of aerobic microorganisms. It convinced that the rapid bio-drying of dairy manure has a good effect and provided a new idea for the effective treatment of cow dung.

  6. Value of databases other than medline for rapid health technology assessments. (United States)

    Lorenzetti, Diane L; Topfer, Leigh-Ann; Dennett, Liz; Clement, Fiona


    The objective of this study was to explore the degree to which databases other than MEDLINE contribute studies relevant for inclusion in rapid health technology assessments (HTA). We determined the extent to which the clinical, economic, and social studies included in twenty-one full and four rapid HTAs published by three Canadian HTA agencies from 2007 to 2012 were indexed in MEDLINE. Other electronic databases, including EMBASE, were then searched, in sequence, to assess whether or not they indexed studies not found in MEDLINE. Assessment topics ranged from purely clinical (e.g., drug-eluting stents) to those with broader social implications (e.g., spousal violence). MEDLINE contributed the majority of studies in all but two HTA reports, indexing a mean of 89.6 percent of clinical studies across all HTAs, and 88.3 percent of all clinical, economic, and social studies in twenty-four of twenty-five HTAs. While EMBASE contributed unique studies to twenty-two of twenty-five HTAs, three rapid HTAs did not include any EMBASE studies. In some instances, PsycINFO and CINAHL contributed as many, if not more, non-MEDLINE studies than EMBASE. Our findings highlight the importance of assessing the topic-specific relative value of including EMBASE, or more specialized databases, in HTA search protocols. Although MEDLINE continues to be a key resource for HTAs, the time and resource limitations inherent in the production of rapid HTAs require that researchers carefully consider the value and limitations of other information sources to identify relevant studies.

  7. The use of rapid review methods in health technology assessments: 3 case studies. (United States)

    Kaltenthaler, Eva; Cooper, Katy; Pandor, Abdullah; Martyn-St James, Marrissa; Chatters, Robin; Wong, Ruth


    Rapid reviews are of increasing importance within health technology assessment due to time and resource constraints. There are many rapid review methods available although there is little guidance as to the most suitable methods. We present three case studies employing differing methods to suit the evidence base for each review and outline some issues to consider when selecting an appropriate method. Three recently completed systematic review short reports produced for the UK National Institute for Health Research were examined. Different approaches to rapid review methods were used in the three reports which were undertaken to inform the commissioning of services within the NHS and to inform future trial design. We describe the methods used, the reasoning behind the choice of methods and explore the strengths and weaknesses of each method. Rapid review methods were chosen to meet the needs of the review and each review had distinctly different challenges such as heterogeneity in terms of populations, interventions, comparators and outcome measures (PICO) and/or large numbers of relevant trials. All reviews included at least 10 randomised controlled trials (RCTs), each with numerous included outcomes. For the first case study (sexual health interventions), very diverse studies in terms of PICO were included. P-values and summary information only were presented due to substantial heterogeneity between studies and outcomes measured. For the second case study (premature ejaculation treatments), there were over 100 RCTs but also several existing systematic reviews. Data for meta-analyses were extracted directly from existing systematic reviews with new RCT data added where available. For the final case study (cannabis cessation therapies), studies included a wide range of interventions and considerable variation in study populations and outcomes. A brief summary of the key findings for each study was presented and narrative synthesis used to summarise results for each

  8. The method of parallel-hierarchical transformation for rapid recognition of dynamic images using GPGPU technology (United States)

    Timchenko, Leonid; Yarovyi, Andrii; Kokriatskaya, Nataliya; Nakonechna, Svitlana; Abramenko, Ludmila; Ławicki, Tomasz; Popiel, Piotr; Yesmakhanova, Laura


    The paper presents a method of parallel-hierarchical transformations for rapid recognition of dynamic images using GPU technology. Direct parallel-hierarchical transformations based on cluster CPU-and GPU-oriented hardware platform. Mathematic models of training of the parallel hierarchical (PH) network for the transformation are developed, as well as a training method of the PH network for recognition of dynamic images. This research is most topical for problems on organizing high-performance computations of super large arrays of information designed to implement multi-stage sensing and processing as well as compaction and recognition of data in the informational structures and computer devices. This method has such advantages as high performance through the use of recent advances in parallelization, possibility to work with images of ultra dimension, ease of scaling in case of changing the number of nodes in the cluster, auto scan of local network to detect compute nodes.

  9. A methodology to enable rapid evaluation of aviation environmental impacts and aircraft technologies (United States)

    Becker, Keith Frederick

    Commercial aviation has become an integral part of modern society and enables unprecedented global connectivity by increasing rapid business, cultural, and personal connectivity. In the decades following World War II, passenger travel through commercial aviation quickly grew at a rate of roughly 8% per year globally. The FAA's most recent Terminal Area Forecast predicts growth to continue at a rate of 2.5% domestically, and the market outlooks produced by Airbus and Boeing generally predict growth to continue at a rate of 5% per year globally over the next several decades, which translates into a need for up to 30,000 new aircraft produced by 2025. With such large numbers of new aircraft potentially entering service, any negative consequences of commercial aviation must undergo examination and mitigation by governing bodies so that growth may still be achieved. Options to simultaneously grow while reducing environmental impact include evolution of the commercial fleet through changes in operations, aircraft mix, and technology adoption. Methods to rapidly evaluate fleet environmental metrics are needed to enable decision makers to quickly compare the impact of different scenarios and weigh the impact of multiple policy options. As the fleet evolves, interdependencies may emerge in the form of tradeoffs between improvements in different environmental metrics as new technologies are brought into service. In order to include the impacts of these interdependencies on fleet evolution, physics-based modeling is required at the appropriate level of fidelity. Evaluation of environmental metrics in a physics-based manner can be done at the individual aircraft level, but will then not capture aggregate fleet metrics. Contrastingly, evaluation of environmental metrics at the fleet level is already being done for aircraft in the commercial fleet, but current tools and approaches require enhancement because they currently capture technology implementation through post

  10. Satellite Sensornet Gateway Technology Infusion Through Rapid Deployments for Environmental Sensing (United States)

    Benzel, T.; Silva, F.; Deschon, A.; Ye, W.; Cho, Y.


    The Satellite Sensornet Gateway (SSG) is an ongoing ESTO Advanced Information Systems Technology project, at the University of Southern California. The major goal of SSG is to develop a turnkey solution for building environmental observation systems based on sensor networks. Our system has been developed through an iterative series of deployment-driven design, build, test, and revise which maximizes technology infusion to the earth scientist. We have designed a robust and flexible sensor network called Sensor Processing and Acquisition Network (SPAN). Our SPAN architecture emphasizes a modular and extensible design, such that core building blocks can be reused to develop different scientific observation systems. To support rapid deployment at remote locations, we employ satellite communications as the backhaul to relay in-situ sensor data to a central database. To easily support various science applications, we have developed a unified sensor integration framework that allows streamlined integration of different sensors to the system. Our system supports heterogeneous sets of sensors, from industry-grade products to research- specific prototypes. To ensure robust operation in harsh environments, we have developed mechanisms to monitor system status and recover from potential failures along with additional remote configuration and QA/QC functions. Here we briefly describe the deployments, the key science missions of the deployments and the role that the SSG technology played in each mission. We first deployed our SSG technology at the James Reserve in February 2007. In a joint deployment with the NEON project, SDSC, and UC Riverside, we set up a meteorological station, using a diverse set of sensors, with the objective of validating our basic technology components in the field. This system is still operational and streaming live sensor data. At Stunt Ranch, a UC Reserve near Malibu, CA, we partnered with UCLA biologist Phillip Rundel in order to study the drought

  11. Rapid Detection of Pediatric Bacteriuria Using Narrow Angle Forward Laser Scattering Technology (NAFLST) with Bacterioscan (United States)

    Cline, Adriana; Jhaveri, Ravi; Levinson, Kara; Miller, Melissa


    Abstract Background Pediatric urinary tract infections (UTI) are common, but culture-based diagnosis can take up to 48 hours. This time delay means patients are exposed to potentially unnecessary antibiotics. The sensitivity of screening urinalysis can vary, so rapid detection of UTI by another means would be beneficial. Narrow Angle Forward Laser Scattering Technology (NAFLST) with Bacterioscan can rapidly detect bacteriuria by shining a laser continuously through a liquid sample containing replicating bacteria, and graphing the degree of light refraction over time. Higher degrees of light refraction represent higher initial bacterial load and continued bacterial growth. After 3 hours, the optical scatter classifies a sample as either Likely Positive or Likely Negative. We compared Bacterioscan results to culture data in pediatric patients to assess the ability to diagnose UTI and avoid unnecessary urine culture. Methods This protocol was approved by the UNC Biomedical Institutional Review Board. Over one month, 169 pediatric (<18 yo) urine cultures were collected as part of routine patient care. An individual urine sample and 2.5mL of Sterile Tryptic Soy Broth were pipetted into a Bacterioscan micro-curette. Bacterioscan labeled the specimen as Likely Positive or Likely Negative after a 3 hour period. Results were then compared with urine culture results obtained by routine microbiologic methods. Results Of the 169 urine cultures, 96 were positive, but only 27 were positive for uropathogens. Bacterioscan was 100% sensitive and 58.4% specific in predicting clinically relevant/pathogenic bacterial growth in culture (PPV 31.3%, NPV 100%), and 70.8% sensitive and 75.3% specific in predicting any bacterial growth (PPV 79.0%, NPV 66.2%). If a “Likely Positive” Bacterioscan result had been used in our study population to screen urine samples for culture, then 58% (83/142) of negative urine cultures would have been eliminated with no UTIs missed. Conclusion By

  12. Technology of Anticorrosive Protection of Steel Constructions by Coatings Based on Rapid-Hardening Bitumen-Latex Emulsion

    Directory of Open Access Journals (Sweden)

    Nykyforchyn, H.M.


    Full Text Available The recipes of rapid-hardening bitumen-latex emulsions and coatings on its base are created, in-laboratory tests of their physical, chemical and anticorrosive properties are carried out. The technology of anticorrosive protection and the installation technical documentation for making of aqueous bitumen-latex emulsion is developed, installation is mounted and a pilot lot of rapid-hardening emulsion is produced. Experimental-industrial approbation of the technology of coating formation on pipes in oil and gas industry is carried out.

  13. Effects of rapid chilling of carcasses and time of deboning on weight loss and technological quality of pork semimembranosus muscle. (United States)

    Tomović, Vladimir M; Petrović, Ljiljana S; Džinić, Natalija R


    The effect of rapid air chilling of carcasses in the first 3 h of chilling at -31°C (then at 2-4°C, till 24 h post-mortem) and the possibility of earlier deboning (8 h post-mortem) after rapid air chilling, compared to conventional air chilling (at 2-4°C, till 24 h post-mortem) on weight loss and technological quality (pH value, tenderness, drip loss, cooking loss and colour - L(∗)a(∗)b(∗) values) of pork M. semimembranosus was investigated. Under the rapid chilling conditions, weight loss was 0.8% at 8 h post-mortem and increased to 1.4% at 24 h post-mortem when weight loss was 2.0% under conventional chilling. Carcasses that were rapid chilled had significantly lower (Pchill treatment (32.7, 24.2, 19.1 and 5.1°C, respectively). Rapid chilling reduced significantly (Pchill treatment (5.88). Compared to conventional chilling, in M. semimembranosus deboned in different time post-mortem, rapid chilling had a positive significant effect on drip loss (Pchilling i.e. rapid chilling and earlier deboning had neither positive nor negative significant effects (P>0.05) on other investigated technological quality parameters of M. semimembranosus (tenderness, a(∗) value and b(∗) value) compared to conventional chilling.

  14. Advanced powder metallurgy aluminum alloys via rapid solidification technology, phase 2 (United States)

    Ray, Ranjan; Jha, Sunil C.


    Marko's rapid solidification technology was applied to processing high strength aluminum alloys. Four classes of alloys, namely, Al-Li based (class 1), 2124 type (class 2), high temperature Al-Fe-Mo (class 3), and PM X7091 type (class 4) alloy, were produced as melt-spun ribbons. The ribbons were pulverized, cold compacted, hot-degassed, and consolidated through single or double stage extrusion. The mechanical properties of all four classes of alloys were measured at room and elevated temperatures and their microstructures were investigated optically and through electron microscopy. The microstructure of class 1 Al-Li-Mg alloy was predominantly unrecrystallized due to Zr addition. Yield strengths to the order of 50 Ksi were obtained, but tensile elongation in most cases remained below 2 percent. The class 2 alloys were modified composition of 2124 aluminum alloy, through addition of 0.6 weight percent Zr and 1 weight percent Ni. Nickel addition gave rise to a fine dispersion of intermetallic particles resisting coarsening during elevated temperature exposure. The class 2 alloy showed good combination of tensile strength and ductility and retained high strength after 1000 hour exposure at 177 C. The class 3 Al-Fe-Mo alloy showed high strength and good ductility both at room and high temperatures. The yield and tensile strength of class 4 alloy exceeded those of the commercial 7075 aluminum alloy.

  15. A rapid automatic analyzer and its methodology for effective bentonite content based on image recognition technology

    Directory of Open Access Journals (Sweden)

    Wei Long


    Full Text Available Fast and accurate determination of effective bentonite content in used clay bonded sand is very important for selecting the correct mixing ratio and mixing process to obtain high-performance molding sand. Currently, the effective bentonite content is determined by testing the ethylene blue absorbed in used clay bonded sand, which is usually a manual operation with some disadvantages including complicated process, long testing time and low accuracy. A rapid automatic analyzer of the effective bentonite content in used clay bonded sand was developed based on image recognition technology. The instrument consists of auto stirring, auto liquid removal, auto titration, step-rotation and image acquisition components, and processor. The principle of the image recognition method is first to decompose the color images into three-channel gray images based on the photosensitive degree difference of the light blue and dark blue in the three channels of red, green and blue, then to make the gray values subtraction calculation and gray level transformation of the gray images, and finally, to extract the outer circle light blue halo and the inner circle blue spot and calculate their area ratio. The titration process can be judged to reach the end-point while the area ratio is higher than the setting value.

  16. Rapid identification and classification of Campylobacter spp. using laser optical scattering technology. (United States)

    He, Yiping; Reed, Sue; Bhunia, Arun K; Gehring, Andrew; Nguyen, Ly-Huong; Irwin, Peter L


    Campylobacter jejuni and Campylobacter coli are the two important species responsible for most of the Campylobacter infections in humans. Reliable isolation and detection of Campylobacter spp. from food samples are challenging due to the interferences from complex food substances and the fastidious growth requirements of this organism. In this study, a novel biosensor-based detection called BARDOT (BActerial Rapid Detection using Optical scattering Technology) was developed for high-throughput screening of Campylobacter colonies grown on an agar plate without disrupting the intact colonies. Image pattern characterization and principal component analysis (PCA) of 6909 bacterial colonies showed that the light scatter patterns of C. jejuni and C. coli were strikingly different from those of Salmonella spp., Escherichia coli O157:H7, and Listeria monocytogenes. Examination of a mixed culture of these microorganisms revealed 85% (34/40) accuracy in differentiating Campylobacter from the other three major foodborne pathogens based on the similarity to the scatter patterns in an established library. The application of BARDOT in real food has been addressed through the analysis of Campylobacter spiked ground chicken and naturally contaminated fresh chicken pieces. Combined with real-time PCR verification, BARDOT was able to identify Campylobacter isolates from retail chicken. Moreover, applying passive filtration to food samples facilitated the isolation of pure Campylobacter colonies and therefore overcame the interference of the food matrix on BARDOT analysis. Published by Elsevier Ltd.

  17. Qualification Testing Versus Quantitative Reliability Testing of PV - Gaining Confidence in a Rapidly Changing Technology: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, Sarah [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Repins, Ingrid L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Hacke, Peter L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Jordan, Dirk [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kempe, Michael D [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Whitfield, Kent [Underwriters Laboratories; Phillips, Nancy [DuPont; Sample, Tony [European Commission; Monokroussos, Christos [TUV Rheinland; Hsi, Edward [Swiss RE; Wohlgemuth, John [PowerMark Corporation; Seidel, Peter [First Solar; Jahn, Ulrike [TUV Rheinland; Tanahashi, Tadanori [National Institute of Advanced Industrial Science and Technology; Chen, Yingnan [China General Certification Center; Jaeckel, Bengt [Underwriters Laboratories; Yamamichi, Masaaki [RTS Corporation


    Continued growth of PV system deployment would be enhanced by quantitative, low-uncertainty predictions of the degradation and failure rates of PV modules and systems. The intended product lifetime (decades) far exceeds the product development cycle (months), limiting our ability to reduce the uncertainty of the predictions for this rapidly changing technology. Yet, business decisions (setting insurance rates, analyzing return on investment, etc.) require quantitative risk assessment. Moving toward more quantitative assessments requires consideration of many factors, including the intended application, consequence of a possible failure, variability in the manufacturing, installation, and operation, as well as uncertainty in the measured acceleration factors, which provide the basis for predictions based on accelerated tests. As the industry matures, it is useful to periodically assess the overall strategy for standards development and prioritization of research to provide a technical basis both for the standards and the analysis related to the application of those. To this end, this paper suggests a tiered approach to creating risk assessments. Recent and planned potential improvements in international standards are also summarized.

  18. Using Rapid Improvement Events for Disaster After-Action Reviews: Experience in a Hospital Information Technology Outage and Response. (United States)

    Little, Charles M; McStay, Christopher; Oeth, Justin; Koehler, April; Bookman, Kelly


    The use of after-action reviews (AARs) following major emergency events, such as a disaster, is common and mandated for hospitals and similar organizations. There is a recurrent challenge of identified problems not being resolved and repeated in subsequent events. A process improvement technique called a rapid improvement event (RIE) was used to conduct an AAR following a complete information technology (IT) outage at a large urban hospital. Using RIE methodology to conduct the AAR allowed for the rapid development and implementation of major process improvements to prepare for future IT downtime events. Thus, process improvement methodology, particularly the RIE, is suited for conducting AARs following disasters and holds promise for improving outcomes in emergency management. Little CM , McStay C , Oeth J , Koehler A , Bookman K . Using rapid improvement events for disaster after-action reviews: experience in a hospital information technology outage and response. Prehosp Disaster Med. 2018;33(1):98-100.

  19. Low-temperature deposition manufacturing: A novel and promising rapid prototyping technology for the fabrication of tissue-engineered scaffold. (United States)

    Liu, Wei; Wang, Daming; Huang, Jianghong; Wei, You; Xiong, Jianyi; Zhu, Weimin; Duan, Li; Chen, Jielin; Sun, Rong; Wang, Daping


    Developed in recent years, low-temperature deposition manufacturing (LDM) represents one of the most promising rapid prototyping technologies. It is not only based on rapid deposition manufacturing process but also combined with phase separation process. Besides the controlled macropore size, tissue-engineered scaffold fabricated by LDM has inter-connected micropores in the deposited lines. More importantly, it is a green manufacturing process that involves non-heating liquefying of materials. It has been employed to fabricate tissue-engineered scaffolds for bone, cartilage, blood vessel and nerve tissue regenerations. It is a promising technology in the fabrication of tissue-engineered scaffold similar to ideal scaffold and the design of complex organs. In the current paper, this novel LDM technology is introduced, and its control parameters, biomedical applications and challenges are included and discussed as well. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Advanced Manufacturing Technologies (AMT): Modular Rapidly Manufactured SmallSat Element (United States)

    National Aeronautics and Space Administration — Rapidly fabricated, modular and integrated small satellite subsystems will be developed from digital fabrication workflows. The following are planned modular...

  1. Rapid and accurate biofuel moisture content gauging using magnetic resonance measurement technology

    Energy Technology Data Exchange (ETDEWEB)

    Jaervinen, T.


    Biomass is extensively utilised in energy production and as a raw material, such as for the production of liquid biofuels. All those processes will benefit if the moisture content of bio material is known in advance as accurately as possible under transient circumstances. Biofuel trade is increasingly based on the calorific value of fuels. In the first step, this also increases the need for rapid and accurate moisture content determination. During the last few years, large biofuel standardisation has been implemented, emphasising biofuel quality control at all stages of the utilisation chain. In principle, the moisture instrumental measurement can be utilised by many technologies and procedures. Typical techniques are infrared, radiofrequency, microwave, radiometric, electrical conductivity, capacitance, and impedance. Nuclear magnetic resonance (MR) and thermal neutron absorption are also applied. The MR measurement principle has been known and utilised already since the early 1950s. It has become the basic instrumental analysis tool in chemistry. It is also well-known as a very accurate method for analysing most compounds, especially substances containing hydrogen. The utilisation of MR metering is expanded extensively to medical diagnostics as a form of magnetic resonance imaging (MRI). Because of the precision of the MR principle, there have for a long time been efforts to apply it in new and different areas, and to make more user-friendly, smaller, and even portable devices. Such a device was designed by Vaisala a few years ago. VTT has utilised Vaisala's MR prototype for approximately one year for moisture content measurement of different biofuels. The first step in the use of an MR device for moisture determination was the definition of its measurement accuracy compared to the standard method (EN 14774). Those tests proved that the absolute precision seems to be comparable to the standard moisture content measurement method. It was also found out that

  2. A Survey of Hardware and Software Technologies for the Rapid Development of Multimedia Instructional Modules (United States)

    Ganesan, Nanda


    A survey of hardware and software technologies was conducted to identify suitable technologies for the development of instructional modules representing various instructional approaches. The approaches modeled were short PowerPoint presentations, chalk-and-talk type of lectures and software tutorials. The survey focused on identifying application…

  3. Evolving Technology, Shifting Expectations: Cultivating Pedagogy for a Rapidly Changing GIS Landscape (United States)

    Ricker, Britta; Thatcher, Jim


    As humans and natural processes continuously reshape the surface of the Earth, there is an unceasing need to document and analyze them through the use of Geographic Information Systems (GIS). The public is gaining more access to spatial technologies that were once only available to highly trained professionals. With technological evolution comes a…

  4. Design and optimization of the micro-engine turbine rotor manufacturing using the rapid prototyping technology (United States)

    Vdovin, R. A.; Smelov, V. G.


    This work describes the experience in manufacturing the turbine rotor for the micro-engine. It demonstrates the design principles for the complex investment casting process combining the use of the ProCast software and the rapid prototyping techniques. At the virtual modelling stage, in addition to optimized process parameters, the casting structure was improved to obtain the defect-free section. The real production stage allowed demonstrating the performance and fitness of rapid prototyping techniques for the manufacture of geometrically-complex engine-building parts.

  5. Current and emerging technologies for rapid detection and characterization of Salmonella in poultry and poultry products. (United States)

    Park, Si Hong; Aydin, Muhsin; Khatiwara, Anita; Dolan, Maureen C; Gilmore, David F; Bouldin, Jennifer L; Ahn, Soohyoun; Ricke, Steven C


    Salmonella is the leading cause of foodborne illnesses in the United States, and one of the main contributors to salmonellosis is the consumption of contaminated poultry and poultry products. Since deleterious effects of Salmonella on public health and the economy continue to occur, there is an ongoing need to develop more advanced detection methods that can identify Salmonella accurately and rapidly in foods before they reach consumers. Rapid detection and identification methods for Salmonella are considered to be an important component of strategies designed to prevent poultry and poultry product-associated illnesses. In the past three decades, there have been increasing efforts towards developing and improving rapid pathogen detection and characterization methodologies for application to poultry and poultry products. In this review, we discuss molecular methods for detection, identification and genetic characterization of Salmonella associated with poultry and poultry products. In addition, the advantages and disadvantages of the established and emerging rapid detection and characterization methods are addressed for Salmonella in poultry and poultry products. The methods with potential application to the industry are highlighted in this review. Copyright © 2013 Elsevier Ltd. All rights reserved.

  6. A Rapid Auto-Indexing Technology for Designing Readable E-Learning Content (United States)

    Yu, Pao-Ta; Liao, Yuan-Hsun; Su, Ming-Hsiang; Cheng, Po-Jen; Pai, Chun-Hsuan


    A rapid scene indexing method is proposed to improve retrieval performance for students accessing instructional videos. This indexing method is applied to anchor suitable indices to the instructional video so that students can obtain several small lesson units to gain learning mastery. The method also regulates online course progress. These…

  7. Rapid inducible protein displacement in Plasmodium in vivo and in vitro using knocksideways technology [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Katie R. Hughes


    Full Text Available A deeper understanding of the biology of the Plasmodium parasite is essential in order to identify targets for interventions, with the ultimate aim of eliminating malaria. Determining the function(s of essential proteins in Plasmodium has, until recently, been hampered by the lack of efficient conditional systems to abrogate proteins. We report the adaptation of a conditional technology, knocksideways (KS, for use in Plasmodium berghei, which can potentially rapidly inactivate proteins of interest through relocalisation. The system is induced using rapamycin, which allows for KS both in vitro and in vivo and is effective more rapidly than any other reported system. KS utilises pairs of fluorescent tags that facilitate live imaging and allows for rapid confirmation of efficient protein redistribution on live parasites, allowing for streamlined workflows. We demonstrate the characteristics of the system using transgenically expressed cytoplasmic GFP and provide proof of principle by inducibly redistributing a number of proteins with different native, subcellular locations.  We also demonstrate that KS can be applied to both mammalian and insect stages of Plasmodium. KS expands the range of (conditional technologies for genetic manipulation of malaria parasites and offers the potential to be further developed for medium throughput phenotype screens.

  8. Is Sordac’s Rapid Acquisition Process Best Prepared To Field Solutions For Future Technological Challenges (United States)


    views expressed in this academic research paper are those of the author and do not reflect the official policy or position of the US government, the...SORDAC) is the Department of Defense (DoD) leader in rapid acquisitions, and its culture and practices should be benchmarked by the other services. This...should be benchmarked by all other services. This essay first examines SORDAC’s acquisition environment and assesses SORDAC’s unique culture. This

  9. Rapid Prototyping Technologies and their Applications in Prosthodontics, a Review of Literature (United States)

    Torabi, Kianoosh; Farjood, Ehsan; Hamedani, Shahram


    The early computer-aided design/computer-aided manufacturing (CAD/CAM) systems were relied exclusively on subtractive methods. In recent years, additive methods by employing rapid prototyping (RP) have progressed rapidly in various fields of dentistry as they have the potential to overcome known drawbacks of subtractive techniques such as fit problems. RP techniques have been exploited to build complex 3D models in medicine since the 1990s. RP has recently proposed successful applications in various dental fields, such as fabrication of implant surgical guides, frameworks for fixed and removable partial dentures, wax patterns for the dental prosthesis, zirconia prosthesis and molds for metal castings, and maxillofacial prosthesis and finally, complete dentures. This paper aimed to offer a comprehensive literature review of various RP methods, particularly in dentistry, that are expected to bring many improvements to the field. A search was made through MEDLINE database and Google scholar search engine. The keywords; ‘rapid prototyping’ and ‘dentistry’ were searched in title/abstract of publications; limited to 2003 to 2013, concerning past decade. The inclusion criterion was the technical researches that predominately included laboratory procedures. The exclusion criterion was meticulous clinical and excessive technical procedures. A total of 106 articles were retrieved, recited by authors and only 50 met the specified inclusion criteria for this review. Selected articles had used rapid prototyping techniques in various fields in dentistry through different techniques. This review depicted the different laboratory procedures employed in this method and confirmed that RP technique have been substantially feasible in dentistry. With advancement in various RP systems, it is possible to benefit from this technique in different dental practices, particularly in implementing dental prostheses for different applications. PMID:25759851

  10. Rapid diagnostic testing for community-acquired pneumonia: can innovative technology for clinical microbiology be exploited? (United States)

    Yu, Victor L; Stout, Janet E


    Two nonsynchronous events have affected the management of community-acquired pneumonia (CAP): spiraling empiricism for CAP and the "golden era" of clinical microbiology. The development of broad-spectrum antibiotics has led to widespread empiric use without ascertaining the etiology of the infecting microbe. Unfortunately, this approach clashes with the second event, which is the advent of molecular-based microbiology that can identify the causative pathogen rapidly at the point of care. The urinary antigen is a most effective rapid test that has allowed targeted therapy for Legionnaire disease at the point of care. The high specificity (> 90%) allows the clinician to administer appropriate anti-Legionella therapy based on a single rapid test; however, its low sensitivity (76%) means that a notable number of cases of Legionnaire disease will go undiagnosed if other tests, especially culture, are not performed. Further, culture for Legionella is not readily available. If a culture is not performed, epidemiologic identification of the source of the bacterium cannot be ascertained by molecular fingerprinting of the patient and the putative source strain. We recommend resurrection of the basic principles of infectious disease, which are to identify the microbial etiology of the infection and to use narrow, targeted antimicrobial therapy. To reduce antimicrobial overuse with subsequent antimicrobial resistance, these basic principles must be applied in concert with traditional and newer tests in the clinical microbiology laboratory.

  11. Immediate facial rehabilitation in cancer patients using CAD-CAM and rapid prototyping technology: a pilot study. (United States)

    Ciocca, Leonardo; Fantini, Massimiliano; Marchetti, Claudio; Scotti, Roberto; Monaco, Carlo


    This study describes the workflow in a procedure to create a provisional facial prosthesis for cancer patients using digital and rapid prototyping technologies without the need for supporting craniofacial implants. An integrated workflow procedure aimed at the construction of provisional silicone prosthesis was used to rehabilitate a facial disfigurement in a patient who had undergone ablative surgery of the midface. A laser scan of the defect was obtained, and a digital model of the patient's face was constructed using virtual mirroring of the healthy side and referencing the "Nose Digital Library." The missing volume of the face was reconstructed, and a rapid-prototyped mold was devised to process the silicone prosthesis. A provisional eyeglasses-supported prosthesis designed with a CAD/CAM-projected titanium substructure was connected using the micro-components of implant prosthetic devices. The workflow described herein offers a viable procedure for quickly restoring facial defects by means of provisional prosthetic rehabilitation.

  12. Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection.

    Directory of Open Access Journals (Sweden)

    Roy Cohen

    Full Text Available Rapid diagnosis for time-sensitive illnesses such as stroke, cardiac arrest, and septic shock is essential for successful treatment. Much attention has therefore focused on new strategies for rapid and objective diagnosis, such as Point-of-Care Tests (PoCT for blood biomarkers. Here we use a biomimicry-based approach to demonstrate a new diagnostic platform, based on enzymes tethered to nanoparticles (NPs. As proof of principle, we use oriented immobilization of pyruvate kinase (PK and luciferase (Luc on silica NPs to achieve rapid and sensitive detection of neuron-specific enolase (NSE, a clinically relevant biomarker for multiple diseases ranging from acute brain injuries to lung cancer. We hypothesize that an approach capitalizing on the speed and catalytic nature of enzymatic reactions would enable fast and sensitive biomarker detection, suitable for PoCT devices.We performed in-vitro, animal model, and human subject studies. First, the efficiency of coupled enzyme activities when tethered to NPs versus when in solution was tested, demonstrating a highly sensitive and rapid detection of physiological and pathological concentrations of NSE. Next, in rat stroke models the enzyme-based assay was able in minutes to show a statistically significant increase in NSE levels in samples taken 1 hour before and 0, 1, 3 and 6 hours after occlusion of the distal middle cerebral artery. Finally, using the tethered enzyme assay for detection of NSE in samples from 20 geriatric human patients, we show that our data match well (r = 0.815 with the current gold standard for biomarker detection, ELISA-with a major difference being that we achieve detection in 10 minutes as opposed to the several hours required for traditional ELISA.Oriented enzyme immobilization conferred more efficient coupled activity, and thus higher assay sensitivity, than non-tethered enzymes. Together, our findings provide proof of concept for using oriented immobilization of active

  13. Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection (United States)

    Cohen, Roy; Lata, James P.; Lee, Yurim; Hernández, Jean C. Cruz; Nishimura, Nozomi; Schaffer, Chris B.; Mukai, Chinatsu; Nelson, Jacquelyn L.; Brangman, Sharon A.; Agrawal, Yash; Travis, Alexander J.


    Background Rapid diagnosis for time-sensitive illnesses such as stroke, cardiac arrest, and septic shock is essential for successful treatment. Much attention has therefore focused on new strategies for rapid and objective diagnosis, such as Point-of-Care Tests (PoCT) for blood biomarkers. Here we use a biomimicry-based approach to demonstrate a new diagnostic platform, based on enzymes tethered to nanoparticles (NPs). As proof of principle, we use oriented immobilization of pyruvate kinase (PK) and luciferase (Luc) on silica NPs to achieve rapid and sensitive detection of neuron-specific enolase (NSE), a clinically relevant biomarker for multiple diseases ranging from acute brain injuries to lung cancer. We hypothesize that an approach capitalizing on the speed and catalytic nature of enzymatic reactions would enable fast and sensitive biomarker detection, suitable for PoCT devices. Methods and findings We performed in-vitro, animal model, and human subject studies. First, the efficiency of coupled enzyme activities when tethered to NPs versus when in solution was tested, demonstrating a highly sensitive and rapid detection of physiological and pathological concentrations of NSE. Next, in rat stroke models the enzyme-based assay was able in minutes to show a statistically significant increase in NSE levels in samples taken 1 hour before and 0, 1, 3 and 6 hours after occlusion of the distal middle cerebral artery. Finally, using the tethered enzyme assay for detection of NSE in samples from 20 geriatric human patients, we show that our data match well (r = 0.815) with the current gold standard for biomarker detection, ELISA—with a major difference being that we achieve detection in 10 minutes as opposed to the several hours required for traditional ELISA. Conclusions Oriented enzyme immobilization conferred more efficient coupled activity, and thus higher assay sensitivity, than non-tethered enzymes. Together, our findings provide proof of concept for using

  14. Terra-Kleen Response Group, Inc. Solvent Extraction Technology Rapid Commercialization Initiative Report (United States)

    Terra-Kleen Response Group Inc. (Terra-Kleen), has commercialized a solvent extraction technology that uses a proprietary extraction solvent to transfer organic constituents from soil to a liquid phase in a batch process at ambient temperatures. The proprietary solvent has a rel...

  15. Rapid and quantitative detection of Brucella by up-converting phosphor technology-based lateral-flow assay. (United States)

    Qu, Qing; Zhu, Ziwen; Wang, Yufei; Zhong, Zhijun; Zhao, Jin; Qiao, Feng; Du, Xinying; Wang, Zhoujia; Yang, Ruifu; Huang, Liuyu; Yu, Yaqin; Zhou, Lei; Chen, Zeliang


    A rapid and quantitative up-converting phosphor technology-based later-flow assay (UPT-LF assay) was developed for on-site detection of Brucella. Different Brucella species both in pure cultures and in spiked samples could be quantitatively detected. The detection limit for pure culture was 5 x 10(6)CFU/ml and the sensitivity for different spiked samples ranged from 2.0 x 10(3) to 3.9 x 10(5)CFU/mg. The UPT-LF assay showed high specificity, reproducibility and stability, providing great potential for Brucella on-site detection.

  16. Haploid technology allows for the efficient and rapid generation of homozygous antibody-accumulating transgenic tobacco plants. (United States)

    Floss, Doreen M; Kumlehn, Jochen; Conrad, Udo; Saalbach, Isolde


    The large-scale production of plant-derived recombinant proteins requires the breeding of lines homozygous for the transgene(s). These can be selected by progeny testing over multiple sexual generations, but a more efficient means is to fix homozygosity in a single generation using doubled haploid technology. In this study, transgenic tobacco plants, hemizygous for both of the independently inherited genes encoding the light and heavy chains of the anti-human immunodeficiency virus monoclonal antibody 2F5, were used to establish embryogenic pollen cultures. The improved protocol employed in this study guaranteed a very high regeneration efficiency, with more than 50% of the regenerants being spontaneously doubled haploids. Hence, there was no requirement to chemically induce chromosome doubling to recover sufficient entirely homozygous recombinants. As expected, approximately 25% of the regenerants were homozygous for both transgenes. Thus, the employment of haploid technology allowed for the efficient and rapid generation of true-breeding tobacco lines accumulating functional immunoglobulins.

  17. Rapid Detection Technology for Pesticides Residues Based on Microelectrodes Impedance Immunosensor

    Directory of Open Access Journals (Sweden)

    Wen Ping Zhao


    Full Text Available Compared with conventional methods, electrochemical immunosensors have many advantages, such as low cost, high sensitivity, and rapid detection, and has certain prospects for realizing real-time-monitoring. In this paper, a design of portable pesticide residues detection instrument was presented based on an electrochemical impedance immunosensor. Firstly, we studied on an impedance immunosensor based on interdigitated array microelectrode (IDAM coupled with magnetic nanobeads-antibody conjugates (MNAC for the pesticide detection. Magnetic nanobeads (diameter 150 nm coated with anti-carbofuran antibodies were used for further amplification of the binding reaction between antibody and hapten (carbofuran. Secondly, in order to develop a portable pesticide residue apparatus, we designed the impedance detection electric circuit. Main work included designing and constructing of the system circuit, designing and debugging of the system software and so on. Thirdly, the apparatus was used for the standard pesticides solutions testing combined with immunosensor to test the reliability and stability. The pesticide added standard recovery was more than 70 % and the impedance test error was less than 5 %. The results showed that the proposed instrument had a good consistence compared with the traditional analytical methods. Thus, it would be a promising rapid detection instrument for pesticide residues in agricultural products.

  18. Product management of making large pieces through Rapid Prototyping PolyJet® technology (United States)

    Belgiu, G.; Cărăuşu, C.; Şerban, D.; Turc, C. G.


    The rapid prototyping process has already become a classic manufacturing process for parts and assemblies, either polymeric or metal parts. Besides the well-known advantages and disadvantages of the process, the use of 3D printers has a great inconvenience: the overall dimensions of the parts are limited. Obviously, there is a possibility to purchase a larger (and more expensive) 3D printer, but there are always larger pieces to be manufactured. One solution to this problem is the splitting of parts into several components that can be manufactured. The component parts can then be assembled in a single piece by known methods such as welding, gluing, screwing, etc. This paper shows our experience in making large pieces on the Strarasys® Objet24 printer, pieces larger than the tray sizes. The results obtained are valid for any 3D printer using the PolyJet® process.

  19. BACs-on-Beads Technology: A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis

    Directory of Open Access Journals (Sweden)

    Sandra García-Herrero


    Full Text Available The risk of fetal aneuploidies is usually estimated based on high resolution ultrasound combined with biochemical determination of criterion in maternal blood, with invasive procedures offered to the population at risk. The purpose of this study was to investigate the effectiveness of a new rapid aneuploidy screening test on amniotic fluid (AF or chorionic villus (CV samples based on BACs-on-Beads (BoBs technology and to compare the results with classical karyotyping by Giemsa banding (G-banding of cultured cells in metaphase as the gold standard technique. The prenatal-BoBs kit was used to study aneuploidies involving chromosomes 13, 18, 21, X, and Y as well as nine microdeletion syndromes in 321 AF and 43 CV samples. G-banding of metaphase cultured cells was performed concomitantly for all prenatal samples. A microarray-based comparative genomic hybridization (aCGH was also carried out in a subset of samples. Prenatal-BoBs results were widely confirmed by classical karyotyping. Only six karyotype findings were not identified by Prenatal-BoBs, all of them due to the known limitations of the technique. In summary, the BACs-on-Beads technology was an accurate, robust, and efficient method for the rapid diagnosis of common aneuploidies and microdeletion syndromes in prenatal samples.

  20. BACs-on-Beads Technology: A Reliable Test for Rapid Detection of Aneuploidies and Microdeletions in Prenatal Diagnosis (United States)

    Martínez-Conejero, José Antonio; Serra, Vicente; Olmo, Inés; Lara, Coral; Simón, Carlos


    The risk of fetal aneuploidies is usually estimated based on high resolution ultrasound combined with biochemical determination of criterion in maternal blood, with invasive procedures offered to the population at risk. The purpose of this study was to investigate the effectiveness of a new rapid aneuploidy screening test on amniotic fluid (AF) or chorionic villus (CV) samples based on BACs-on-Beads (BoBs) technology and to compare the results with classical karyotyping by Giemsa banding (G-banding) of cultured cells in metaphase as the gold standard technique. The prenatal-BoBs kit was used to study aneuploidies involving chromosomes 13, 18, 21, X, and Y as well as nine microdeletion syndromes in 321 AF and 43 CV samples. G-banding of metaphase cultured cells was performed concomitantly for all prenatal samples. A microarray-based comparative genomic hybridization (aCGH) was also carried out in a subset of samples. Prenatal-BoBs results were widely confirmed by classical karyotyping. Only six karyotype findings were not identified by Prenatal-BoBs, all of them due to the known limitations of the technique. In summary, the BACs-on-Beads technology was an accurate, robust, and efficient method for the rapid diagnosis of common aneuploidies and microdeletion syndromes in prenatal samples. PMID:24795887

  1. A Survey of the Rapidly Emerging Field of Nanotechnology: Potential Applications for Scientific Instruments and Technologies for Atmospheric Entry Probes (United States)

    Meyyappan, M.; Arnold, J. O.


    The field of Nanotechnology is well funded worldwide and innovations applicable to Solar System Exploration are emerging much more rapidly than thought possible just a few years ago. This presentation will survey recent innovations from nanotechnololgy with a focus on novel applications to atmospheric entry science and probe technology, in a fashion similar to that presented by Arnold and Venkatapathy at the previous workshop forum at Lisbon Portugal, October 6-9, 2003. Nanotechnology is a rapidly emerging field that builds systems, devices and materials from the bottom up, atom by atom, and in so doing provides them with novel and remarkable macro-scale performance. This technology has the potential to revolutionize space exploration by reducing mass and simultaneously increasing capability. Thermal, Radiation, Impact Protective Shields: Atmospheric probes and humans on long duration deep space missions involved in Solar System Exploration must safely endure 3 significant hazards: (i) atmospheric entry; (ii) radiation; and (iii) micrometeorite or debris impact. Nanostructured materials could be developed to address all three hazards with a single protective shield, which would involve much less mass than a traditional approach. The concept can be ready in time for incorporation into NASA s Crew Exploration Vehicle, and possible entry probes to fly on the Jupiter Icy Moons

  2. Prenatal BACs-on-Beads™ : a new technology for rapid detection of aneuploidies and microdeletions in prenatal diagnosis. (United States)

    Vialard, F; Simoni, G; Aboura, A; De Toffol, S; Molina Gomes, D; Marcato, L; Serero, S; Clement, P; Bouhanna, P; Rouleau, E; Grimi, B; Selva, J; Gaetani, E; Maggi, F; Joseph, A; Benzacken, B; Grati, F R


    Molecular cytogenetic techniques on uncultured prenatal samples are the sole tests applied in some countries in cases with advanced maternal age (AMA) or increased risk after prenatal screening. Moreover, there is a trend to perform invasive prenatal diagnosis (PD) during the first trimester before ultrasound manifestations, so new rapid and reliable assays are necessary to investigate microdeletions not detectable with the conventional karyotype. We report the validation study of the prenatal bacterial artificial chromosomes-on-Beads™ (BoBs™ ; CE-IVD), a bead-based multiplex assay detecting chromosomes 13, 18, 21, X/Y aneuploidies and nine microdeletion regions having an overall detection rate of 1/1700. We retrospectively studied 408 selected samples and prospectively tested 212 consecutive samples ascertained for conventional karyotyping. We did not find false-positive results. Triploidies were not detected. Maternal cell contamination of male samples up to 90% was unmasked inspecting gonosome profiles. Mosaic conditions at 20 to 30% were revealed. Failures were due to low amount of DNA. Prenatal BoBs™ is a robust technology for the investigation of fetuses with normal karyotype with or without sonographic abnormalities. Running in parallel with the karyotype analysis, it can be proposed instead of rapid FISH or QF-PCR providing rapid results on common aneuploidies and additional information regarding the microdeletion syndromes. Copyright © 2011 John Wiley & Sons, Ltd.

  3. Can mobile phone technology support a rapid sharing of information on novel psychoactive substances among health and other professionals internationally? (United States)

    Simonato, Pierluigi; Bersani, Francesco S; Santacroce, Rita; Cinosi, Eduardo; Schifano, Fabrizio; Bersani, Giuseppe; Martinotti, Giovanni; Corazza, Ornella


    The diffusion of novel psychoactive substances (NPSs), combined with the ability of the Internet to act as an online marketplace, has led to unprecedented challenges for governments, health agencies, and substance misuse services. Despite increasing research, there is a paucity of reliable information available to professionals working in the field. The paper will present the pilot results of the first mobile application (SMAIL) for rapid information sharing on NPSs among health professionals. The development of SMAIL was divided into 2 parts: (a) the creation of the application for registered users, enabling them to send an SMS or email with the name or "street name" of an NPS and receive within seconds emails or SMS with the information, when available and (b) the development of a database to support the incoming requests. One hundred twenty-two professionals based in 22 countries used the service over the pilot period of 16 months (from May 2012 to September 2013). Five hundred fifty-seven enquires were made. Users received rapid information on NPSs, and 61% of them rated the service as excellent. This is the right time to use mobile phone technologies for rapid information sharing and prevention activities on NPSs. Copyright © 2017 John Wiley & Sons, Ltd.

  4. [Rapid Identification of Epicarpium Citri Grandis via Infrared Spectroscopy and Fluorescence Spectrum Imaging Technology Combined with Neural Network]. (United States)

    Pan, Sha-sha; Huang, Fu-rong; Xiao, Chi; Xian, Rui-yi; Ma, Zhi-guo


    To explore rapid reliable methods for detection of Epicarpium citri grandis (ECG), the experiment using Fourier Transform Attenuated Total Reflection Infrared Spectroscopy (FTIR/ATR) and Fluorescence Spectrum Imaging Technology combined with Multilayer Perceptron (MLP) Neural Network pattern recognition, for the identification of ECG, and the two methods are compared. Infrared spectra and fluorescence spectral images of 118 samples, 81 ECG and 37 other kinds of ECG, are collected. According to the differences in tspectrum, the spectra data in the 550-1 800 cm(-1) wavenumber range and 400-720 nm wavelength are regarded as the study objects of discriminant analysis. Then principal component analysis (PCA) is applied to reduce the dimension of spectroscopic data of ECG and MLP Neural Network is used in combination to classify them. During the experiment were compared the effects of different methods of data preprocessing on the model: multiplicative scatter correction (MSC), standard normal variable correction (SNV), first-order derivative(FD), second-order derivative(SD) and Savitzky-Golay (SG). The results showed that: after the infrared spectra data via the Savitzky-Golay (SG) pretreatment through the MLP Neural Network with the hidden layer function as sigmoid, we can get the best discrimination of ECG, the correct percent of training set and testing set are both 100%. Using fluorescence spectral imaging technology, corrected by the multiple scattering (MSC) results in the pretreatment is the most ideal. After data preprocessing, the three layers of the MLP Neural Network of the hidden layer function as sigmoid function can get 100% correct percent of training set and 96.7% correct percent of testing set. It was shown that the FTIR/ATR and fluorescent spectral imaging technology combined with MLP Neural Network can be used for the identification study of ECG and has the advantages of rapid, reliable effect.

  5. Application of 3D rapid prototyping technology in posterior corrective surgery for Lenke 1 adolescent idiopathic scoliosis patients. (United States)

    Yang, Mingyuan; Li, Chao; Li, Yanming; Zhao, Yingchuan; Wei, Xianzhao; Zhang, Guoyou; Fan, Jianping; Ni, Haijian; Chen, Ziqiang; Bai, Yushu; Li, Ming


    A retrospective study to evaluate the effectiveness of 3-dimensional rapid prototyping (3DRP) technology in corrective surgery for Lenke 1 adolescent idiopathic scoliosis (AIS) patients. 3DRP technology has been widely used in medical field; however, no study has been performed on the effectiveness of 3DRP technology in corrective surgery for Lenke 1 AIS patients. Lenke 1 AIS patients who were preparing to undergo posterior corrective surgery from a single center between January 2010 and January 2012 were included in this analysis. Patients were divided into 2 groups. In group A, 3-dimensional (3D) printing technology was used to create subject-specific spine models in the preoperative planning process. Group B underwent posterior corrective surgery as usual (by free hand without image guidance). Perioperative and postoperative clinical outcomes were compared between 2 groups, including operation time, perioperative blood loss, transfusion volume, postoperative hemoglobin (Hb), postoperative complications, and length of hospital stay. Radiological outcomes were also compared, including the assessment of screw placement, postoperative Cobb angle, coronal balance, sagittal vertical axis, thoracic kyphosis, and lumbar lordosis. Subgroup was also performed according to the preoperative Cobb angle: mean Cobb angle Cobb angle >50°. Besides, economic evaluation was also compared between 2 groups. A total of 126 patients were included in this study (group A, 50 and group B, 76). Group A had significantly shorter operation time, significantly less blood loss and transfusion volume, and higher postoperative Hb (all, P 0.05). There was also no significant difference in misplacement of screws in total populations (16.90% vs 18.82%, P = 0.305), whereas a low misplacement rate of pedicle screws was observed in patients whose mean Cobb angle was >50° (9.15% vs 13.03%, P = 0.02). Besides, using 3DRP increased the economic burden of patients (157,000 ± 9948.85

  6. Rapid prototyping of multi-scale biomedical microdevices by combining additive manufacturing technologies. (United States)

    Hengsbach, Stefan; Lantada, Andrés Díaz


    The possibility of designing and manufacturing biomedical microdevices with multiple length-scale geometries can help to promote special interactions both with their environment and with surrounding biological systems. These interactions aim to enhance biocompatibility and overall performance by using biomimetic approaches. In this paper, we present a design and manufacturing procedure for obtaining multi-scale biomedical microsystems based on the combination of two additive manufacturing processes: a conventional laser writer to manufacture the overall device structure, and a direct-laser writer based on two-photon polymerization to yield finer details. The process excels for its versatility, accuracy and manufacturing speed and allows for the manufacture of microsystems and implants with overall sizes up to several millimeters and with details down to sub-micrometric structures. As an application example we have focused on manufacturing a biomedical microsystem to analyze the impact of microtextured surfaces on cell motility. This process yielded a relevant increase in precision and manufacturing speed when compared with more conventional rapid prototyping procedures.

  7. Rapid detection of structural variation in a human genome using nanochannel-based genome mapping technology

    DEFF Research Database (Denmark)

    Cao, Hongzhi; Hastie, Alex R.; Cao, Dandan


    BACKGROUND: Structural variants (SVs) are less common than single nucleotide polymorphisms and indels in the population, but collectively account for a significant fraction of genetic polymorphism and diseases. Base pair differences arising from SVs are on a much higher order (>100 fold) than poi...... mapping technology as a comprehensive and cost-effective method for detecting structural variation and studying complex regions in the human genome, as well as deciphering viral integration into the host genome.......BACKGROUND: Structural variants (SVs) are less common than single nucleotide polymorphisms and indels in the population, but collectively account for a significant fraction of genetic polymorphism and diseases. Base pair differences arising from SVs are on a much higher order (>100 fold) than point...... mutations; however, none of the current detection methods are comprehensive, and currently available methodologies are incapable of providing sufficient resolution and unambiguous information across complex regions in the human genome. To address these challenges, we applied a high-throughput, cost...

  8. Information Technology Research Services: Powerful Tools to Keep Up with a Rapidly Moving Field (United States)

    Hunter, Paul


    Marty firms offer Information Technology Research reports, analyst calls, conferences, seminars, tools, leadership development, etc. These entities include Gartner, Forrester Research, IDC, The Burton Group, Society for Information Management, 1nfoTech Research, The Corporate Executive Board, and so on. This talk will cover how a number of such services are being used at the Goddard Space Flight Center to improve our IT management practices, workforce skills, approach to innovation, and service delivery. These tools and services are used across the workforce, from the executive leadership to the IT worker. The presentation will cover the types of services each vendor provides and their primary engagement model. The use of these services at other NASA Centers and Headquarters will be included. In addition, I will explain how two of these services are available now to the entire NASA IT workforce through enterprise-wide subscriptions.

  9. Dental occlusion ties: A rapid, safe, and non‐invasive maxillo‐mandibular fixation technology (United States)


    Objectives For decades, Erich arch bars have been a standard in establishing maxillo‐mandibular fixation (MMF). While reliable, the approach risks sharps injury, consumes operating room time, and inflicts gingival trauma. Newer technologies including screw‐based techniques and “hybrid” techniques have improved MMF by reducing sharps injuries and operating room time, but risk injury to tooth roots, nerves, and gingiva. This study aims to establish the application, strengths, and limitations of dental occlusion ties as a novel alternative in maxillo‐mandibular fixation. Study Design Prospective, non‐blinded, human feasibility clinical trial. Materials and Methods An iterative prototyping process was used to invent dental occlusion ties (brand name: Minne Ties). Development included 3D printing, cadaver prototype testing, human apical embrasure measurement, and ultimately non‐significant risk human clinical trial testing. In the IRB‐approved feasibility clinical trial, the devices were applied to mandible and maxilla fracture candidates with fractures amenable to intra‐operative MMF with open reduction with internal fixation. The ties were removed prior to extubation. Pre‐teens, comminuted fracture patients, and patients requiring post‐operative MMF were excluded. Results Manufactured, sterile prototypes secured MMF successfully in management of unilateral and bilateral mandible and maxilla fractures. All patients reported correction of pre‐operative malocclusion. Application times were typically 12–15 minutes for a single surgeon to achieve MMF. Patients incurred negligible gingival trauma from the technology as the ties require no tissue penetration for application. Conclusions Dental occlusion ties offer a non‐invasive solution featuring operating room efficiency, minimized sharps risk, and less bony and soft tissue trauma than current commercialized solutions. Level of Evidence Therapeutic, IV PMID:28894837

  10. Dental occlusion ties: A rapid, safe, and non-invasive maxillo-mandibular fixation technology. (United States)

    Johnson, Alan W


    For decades, Erich arch bars have been a standard in establishing maxillo-mandibular fixation (MMF). While reliable, the approach risks sharps injury, consumes operating room time, and inflicts gingival trauma. Newer technologies including screw-based techniques and "hybrid" techniques have improved MMF by reducing sharps injuries and operating room time, but risk injury to tooth roots, nerves, and gingiva. This study aims to establish the application, strengths, and limitations of dental occlusion ties as a novel alternative in maxillo-mandibular fixation. Prospective, non-blinded, human feasibility clinical trial. An iterative prototyping process was used to invent dental occlusion ties (brand name: Minne Ties). Development included 3D printing, cadaver prototype testing, human apical embrasure measurement, and ultimately non-significant risk human clinical trial testing. In the IRB-approved feasibility clinical trial, the devices were applied to mandible and maxilla fracture candidates with fractures amenable to intra-operative MMF with open reduction with internal fixation. The ties were removed prior to extubation. Pre-teens, comminuted fracture patients, and patients requiring post-operative MMF were excluded. Manufactured, sterile prototypes secured MMF successfully in management of unilateral and bilateral mandible and maxilla fractures. All patients reported correction of pre-operative malocclusion. Application times were typically 12-15 minutes for a single surgeon to achieve MMF. Patients incurred negligible gingival trauma from the technology as the ties require no tissue penetration for application. Dental occlusion ties offer a non-invasive solution featuring operating room efficiency, minimized sharps risk, and less bony and soft tissue trauma than current commercialized solutions. Therapeutic, IV.

  11. A validation study of reconstructed rapid prototyping models produced by two technologies. (United States)

    Dietrich, Christian Andreas; Ender, Andreas; Baumgartner, Stefan; Mehl, Albert


    To determine the accuracy (trueness and precision) of two different rapid prototyping (RP) techniques for the physical reproduction of three-dimensional (3D) digital orthodontic study casts, a comparative assessment using two 3D STL files of two different maxillary dentitions (two cases) as a reference was accomplished. Five RP replicas per case were fabricated using both stereolithography (SLA) and the PolyJet system. The 20 reproduced casts were digitized with a highly accurate reference scanner, and surface superimpositions were performed. Precision was measured by superimposing the digitized replicas within each case with themselves. Superimposing the digitized replicas with the corresponding STL reference files assessed trueness. Statistical significance between the two tested RP procedures was evaluated with independent-sample t-tests (P < .05). The SLA and PolyJet replicas showed statistically significant differences for trueness and precision. The precision of both tested RP systems was high, with mean deviations in stereolithographic models of 23 (±6) μm and in PolyJet replicas of 46 (±13) μm. The mean deviation for trueness in stereolithographic replicas was 109 (±4) μm, while in PolyJet replicas, it was 66 (±14) μm. Comparing the STL reference files, the PolyJet replicas showed higher trueness than the SLA models. But the precision measurements favored the SLA technique. The dimensional errors observed in this study were a maximum of 127 μm. In the present study, both types of reproduced digital orthodontic models are suitable for diagnostics and treatment planning.

  12. Real-Time Digital Bright Field Technology for Rapid Antibiotic Susceptibility Testing. (United States)

    Canali, Chiara; Spillum, Erik; Valvik, Martin; Agersnap, Niels; Olesen, Tom


    Optical scanning through bacterial samples and image-based analysis may provide a robust method for bacterial identification, fast estimation of growth rates and their modulation due to the presence of antimicrobial agents. Here, we describe an automated digital, time-lapse, bright field imaging system (oCelloScope, BioSense Solutions ApS, Farum, Denmark) for rapid and higher throughput antibiotic susceptibility testing (AST) of up to 96 bacteria-antibiotic combinations at a time. The imaging system consists of a digital camera, an illumination unit and a lens where the optical axis is tilted 6.25° relative to the horizontal plane of the stage. Such tilting grants more freedom of operation at both high and low concentrations of microorganisms. When considering a bacterial suspension in a microwell, the oCelloScope acquires a sequence of 6.25°-tilted images to form an image Z-stack. The stack contains the best-focus image, as well as the adjacent out-of-focus images (which contain progressively more out-of-focus bacteria, the further the distance from the best-focus position). The acquisition process is repeated over time, so that the time-lapse sequence of best-focus images is used to generate a video. The setting of the experiment, image analysis and generation of time-lapse videos can be performed through a dedicated software (UniExplorer, BioSense Solutions ApS). The acquired images can be processed for online and offline quantification of several morphological parameters, microbial growth, and inhibition over time.

  13. Rapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology

    Directory of Open Access Journals (Sweden)

    Sven Kruspe


    Full Text Available A challenge for circulating tumor cell (CTC-based diagnostics is the development of simple and inexpensive methods that reliably detect the diverse cells that make up CTCs. CTC-derived nucleases are one category of proteins that could be exploited to meet this challenge. Advantages of nucleases as CTC biomarkers include: (1 their elevated expression in many cancer cells, including cells implicated in metastasis that have undergone epithelial-to-mesenchymal transition; and (2 their enzymatic activity, which can be exploited for signal amplification in detection methods. Here, we describe a diagnostic assay based on quenched fluorescent nucleic acid probes that detect breast cancer CTCs via their nuclease activity. This assay exhibited robust performance in distinguishing breast cancer patients from healthy controls, and it is rapid, inexpensive, and easy to implement in most clinical labs. Given its broad applicability, this technology has the potential to have a substantive impact on the diagnosis and treatment of many cancers.

  14. Characterization of a Reconfigurable Free-Space Optical Channel for Embedded Computer Applications with Experimental Validation Using Rapid Prototyping Technology

    Directory of Open Access Journals (Sweden)

    Lim Theodore


    Full Text Available Free-space optical interconnects (FSOIs are widely seen as a potential solution to current and future bandwidth bottlenecks for parallel processors. In this paper, an FSOI system called optical highway (OH is proposed. The OH uses polarizing beam splitter-liquid crystal plate (PBS/LC assemblies to perform reconfigurable beam combination functions. The properties of the OH make it suitable for embedding complex network topologies such as completed connected mesh or hypercube. This paper proposes the use of rapid prototyping technology for implementing an optomechanical system suitable for studying the reconfigurable characteristics of a free-space optical channel. Additionally, it reports how the limited contrast ratio of the optical components can affect the attenuation of the optical signal and the crosstalk caused by misdirected signals. Different techniques are also proposed in order to increase the optical modulation amplitude (OMA of the system.

  15. Characterization of a Reconfigurable Free-Space Optical Channel for Embedded Computer Applications with Experimental Validation Using Rapid Prototyping Technology

    Directory of Open Access Journals (Sweden)

    Rafael Gil-Otero


    Full Text Available Free-space optical interconnects (FSOIs are widely seen as a potential solution to current and future bandwidth bottlenecks for parallel processors. In this paper, an FSOI system called optical highway (OH is proposed. The OH uses polarizing beam splitter-liquid crystal plate (PBS/LC assemblies to perform reconfigurable beam combination functions. The properties of the OH make it suitable for embedding complex network topologies such as completed connected mesh or hypercube. This paper proposes the use of rapid prototyping technology for implementing an optomechanical system suitable for studying the reconfigurable characteristics of a free-space optical channel. Additionally, it reports how the limited contrast ratio of the optical components can affect the attenuation of the optical signal and the crosstalk caused by misdirected signals. Different techniques are also proposed in order to increase the optical modulation amplitude (OMA of the system.


    Directory of Open Access Journals (Sweden)

    A. N. Petin


    .The application of GIS-technologies allows one in the operative mode to provide the necessary cartographic materials for the authorities and agricultural producers with various time and spatial generalization for making managerial decisions on optimization of regional agricultural complex. 

  17. Application of Computer-Aided Designing and Rapid Prototyping Technologies in Reconstruction of Blowout Fractures of the Orbital Floor. (United States)

    Tabaković, Saša Z; Konstantinović, Vitomir S; Radosavljević, Radivoje; Movrin, Dejan; Hadžistević, Miodrag; Hatab, Nur


    Traumatology of the maxillofacial region represents a wide range of different types of facial skeletal injuries and encompasses numerous treatment methods. Application of computer-aided design (CAD) in combination with rapid prototyping (RP) technologies and three-dimensional computed tomography techniques facilitates surgical therapy planning for efficient treatment. The purpose of this study is to determine the efficiency of individually designed implants of poly-DL-lactide (PDLLA) in the reconstruction of blowout fractures of the orbital floor. In the course of a surgical treatment, individually designed implants manufactured by CAD/RP technologies were used. Preoperative analysis and postoperative monitoring were conducted to evaluate the successfulness of orbital floor reconstruction using customized PDLLA implants, based on: presence of diplopia, paresthesia of infraorbital nerve, and presence of enophthalmos. In 6 of the 10 patients, diplopia completely disappeared immediately after surgical procedure. Diplopia gradually disappeared after 1 month in 3 patients, whereas in 1, it remained even after 6 months. In 7 patients, paresthesia disappeared within a month after surgery and in 3 patients within 2 months. Postoperative average Orbital volume (OV) of the injured side (13.333 ± 3.177) was significantly reduced in comparison with preoperative OV (15.847 ± 3.361) after reconstruction of the orbital floor with customized PDLLA implant (P virtual preoperative modeling allows easier preoperative preparation and yields satisfactory functional and esthetic outcomes.

  18. Affinity purification of Car9-tagged proteins on silica matrices: Optimization of a rapid and inexpensive protein purification technology. (United States)

    Soto-Rodríguez, Jessica; Coyle, Brandon L; Samuelson, Ariana; Aravagiri, Kannan; Baneyx, François


    Car9, a dodecapeptide identified by cell surface display for its ability to bind to the edge of carbonaceous materials, also binds to silica with high affinity. The interaction can be disrupted with l-lysine or l-arginine, enabling a broad range of technological applications. Previously, we reported that C-terminal Car9 extensions support efficient protein purification on underivatized silica. Here, we show that the Car9 tag is functional and TEV protease-excisable when fused to the N-termini of target proteins, and that it supports affinity purification under denaturing conditions, albeit with reduced yields. We further demonstrate that capture of Car9-tagged proteins is enhanced on small particle size silica gels with large pores, that the concomitant problem of nonspecific protein adsorption can be solved by lysing cells in the presence of 0.3% Tween 20, and that efficient elution is achieved at reduced l-lysine concentrations under alkaline conditions. An optimized small-scale purification kit incorporating the above features allows Car9-tagged proteins to be inexpensively recovered in minutes with better than 90% purity. The Car9 affinity purification technology should prove valuable for laboratory-scale applications requiring rapid access to milligram-quantities of proteins, and for preparative scale purification schemes where cost and productivity are important factors. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Development of a rapid serological assay for the diagnosis of strongyloidiasis using a novel diffraction-based biosensor technology.

    Directory of Open Access Journals (Sweden)

    Brian J Pak


    Full Text Available Strongyloidiasis is a persistent human parasitic infection caused by the intestinal nematode, Strongyloides stercoralis. The parasite has a world-wide distribution, particularly in tropical and subtropical regions with poor sanitary conditions. Since individuals with strongyloidiasis are typically asymptomatic, the infection can persist for decades without detection. Problems arise when individuals with unrecognized S. stercoralis infection are immunosuppressed, which can lead to hyper-infection syndrome and disseminated disease with an associated high mortality if untreated. Therefore a rapid, sensitive and easy to use method of diagnosing Strongyloides infection may improve the clinical management of this disease.An immunological assay for diagnosing strongyloidiasis was developed on a novel diffraction-based optical bionsensor technology. The test employs a 31-kDa recombinant antigen called NIE derived from Strongyloides stercoralis L3-stage larvae. Assay performance was tested using retrospectively collected sera from patients with parasitologically confirmed strongyloidiasis and control sera from healthy individuals or those with other parasitoses including schistosomiasis, trichinosis, echinococcosis or amebiasis who were seronegative using the NIE ELISA assay. If we consider the control group as the true negative group, the assay readily differentiated S. stercoralis-infected patients from controls detecting 96.3% of the positive cases, and with no cross reactivity observed in the control group These results were in excellent agreement (κ = 0.98 with results obtained by an NIE-based enzyme-linked immunosorbent assay (ELISA. A further 44 sera from patients with suspected S. stercoralis infection were analyzed and showed 91% agreement with the NIE ELISA.In summary, this test provides high sensitivity detection of serum IgG against the NIE Strongyloides antigen. The assay is easy to perform and provides results in less than 30 minutes

  20. A transferable approach towards rapid inventory data capturing for seismic vulnerability assessment using open-source geospatial technologies (United States)

    Wieland, M.; Pittore, M.; Parolai, S.; Zschau, J.


    Geospatial technologies are increasingly being used in pre-disaster vulnerability assessment and post-disaster impact assessment for different types of hazards. Especially the use of remote sensing data has been strongly promoted in recent years due to its capabilities of providing up-to-date information over large areas at a comparatively low cost with increasingly high spatial, temporal and spectral resolution. Despite its clear potentials, a purely remote sensing based approach has its limitations in that it is only capable of providing information about the birds-eye view of the objects of interest. The use of omnidirectional imaging in addition can provide the necessary street-view that furthermore allows for a rapid visual screening of a buildings façade. In this context, we propose an integrated approach to rapid inventory data capturing for the assessment of structural vulnerability of buildings in case of an earthquake. Globally available low-cost data sources are preferred and the tools are developed on an open-source basis to allow for a high degree of transferability and usability. On a neighbourhood scale medium spatial but high temporal and spectral resolution satellite images are analysed to outline areas of homogeneous urban structure. Following a proportional allocation scheme, for each urban structure type representative sample areas are selected for a more detailed analysis of the building stock with high resolution image data. On a building-by-building scale a ground-based, rapid visual survey is performed using an omnidirectional imaging system driven around with a car inside the identified sample areas. Processing of the acquired images allows for an extraction of vulnerability-related features of single buildings (e.g. building height, detection of soft-storeys). An analysis of high resolution satellite images provides with further inventory features (e.g. footprint area, shape irregularity). Since we are dealing with information coming from

  1. SSR-patchwork: An optimized protocol to obtain a rapid and inexpensive SSR library using first-generation sequencing technology. (United States)

    Di Maio, Antonietta; De Castro, Olga


    We have optimized a version of a microsatellite loci isolation protocol for first-generation sequencing (FGS) technologies. The protocol is optimized to reduce the cost and number of steps, and it combines some procedures from previous simple sequence repeat (SSR) protocols with several key improvements that significantly affect the final yield of the SSR library. This protocol may be accessible for laboratories with a moderate budget or for which next-generation sequencing (NGS) is not readily available. • We drew from classic protocols for library enrichment by digestion, ligation, amplification, hybridization, cloning, and sequencing. Three different systems were chosen: two with very different genome sizes (Galdieria sulphuraria, 10 Mbp; Pancratium maritimum, 30 000 Mbp), and a third with an undetermined genome size (Kochia saxicola). Moreover, we also report the optimization of the sequencing reagents. A good frequency of the obtained microsatellite loci was achieved. • The method presented here is very detailed; comparative tests with other SSR protocols are also reported. This optimized protocol is a promising tool for low-cost genetic studies and the rapid, simple construction of homemade SSR libraries for small and large genomes.

  2. Development of rapid bioconversion with integrated recycle technology for ethanol production from extractive ammonia pretreated corn stover. (United States)

    Jin, Mingjie; Liu, Yanping; da Costa Sousa, Leonardo; Dale, Bruce E; Balan, Venkatesh


    High enzyme loading and low productivity are two major issues impeding low cost ethanol production from lignocellulosic biomass. This work applied rapid bioconversion with integrated recycle technology (RaBIT) and extractive ammonia (EA) pretreatment for conversion of corn stover (CS) to ethanol at high solids loading. Enzymes were recycled via recycling unhydrolyzed solids. Enzymatic hydrolysis with recycled enzymes and fermentation with recycled yeast cells were studied. Both enzymatic hydrolysis time and fermentation time were shortened to 24 h. Ethanol productivity was enhanced by two times and enzyme loading was reduced by 30%. Glucan and xylan conversions reached as high as 98% with an enzyme loading of as low as 8.4 mg protein per g glucan. The overall ethanol yield was 227 g ethanol/kg EA-CS (191 g ethanol/kg untreated CS). Biotechnol. Bioeng. 2017;114: 1713-1720. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  3. Rapid analysis and quantification of fluorescent brighteners in wheat flour by Tri-step infrared spectroscopy and computer vision technology (United States)

    Guo, Xiao-Xi; Hu, Wei; Liu, Yuan; Gu, Dong-Chen; Sun, Su-Qin; Xu, Chang-Hua; Wang, Xi-Chang


    Fluorescent brightener, industrial whitening agent, has been illegally used to whitening wheat flour. In this article, computer vision technology (E-eyes) and colorimetry were employed to investigate color difference among different concentrations of fluorescent brightener in wheat flour using DMS as an example. Tri-step infrared spectroscopy (Fourier transform-infrared spectroscopy coupled with second derivative infrared spectroscopy (SD-IR) and two dimensional correlation infrared spectroscopy (2DCOS-IR)) was used to identify and quantitate DMS in wheat flour. According to color analysis, the whitening effect was significant when added with less than 30 mg/g DMS but when more than 100 mg/g, the flour began greenish. Thus it was speculated that the concentration of DMS should be below 100 mg/g in real flour adulterant with DMS. With the increase of the concentration, the spectral similarity of wheat flour with DMS to DMS standard was increasing. SD-IR peaks at 1153 cm-1, 1141 cm-1, 1112 cm-1, 1085 cm-1 and 1025 cm-1 attributed to DMS were regularly enhanced. Furthermore, it could be differentiated by 2DOS-IR between DMS standard and wheat flour added with DMS low to 0.05 mg/g and the bands in the range of 1000-1500 cm-1 could be an exclusive range to identify whether wheat flour contained DMS. Finally, a quantitative prediction model based on IR spectra was established successfully by Partial least squares (PLS) with a concentration range from 1 mg/g to 100 mg/g. The calibration set gave a determination coefficient of 0.9884 with a standard error (RMSEC) of 5.56 and the validation set presented a determination coefficient of 0.9881 with a standard error of 5.73. It was demonstrated that computer vision technology and colorimetry were effective to estimate the content of DMS in wheat flour and the Tri-step infrared macro-fingerprinting combined with PLS was applicable for rapid and nondestructive fluorescent brightener identification and quantitation.

  4. Kinect Technology Game Play to Mimic Quake Catcher Network (QCN) Sensor Deployment During a Rapid Aftershock Mobilization Program (RAMP) (United States)

    Kilb, D. L.; Yang, A.; Rohrlick, D.; Cochran, E. S.; Lawrence, J.; Chung, A. I.; Neighbors, C.; Choo, Y.


    The Kinect technology allows for hands-free game play, greatly increasing the accessibility of gaming for those uncomfortable using controllers. How it works is the Kinect camera transmits invisible near-infrared light and measures its "time of flight" to reflect off an object, allowing it to distinguish objects within 1 centimeter in depth and 3 mm in height and width. The middleware can also respond to body gestures and voice commands. Here, we use the Kinect Windows SDK software to create a game that mimics how scientists deploy seismic instruments following a large earthquake. The educational goal of the game is to allow the players to explore 3D space as they learn about the Quake Catcher Network's (QCN) Rapid Aftershock Mobilization Program (RAMP). Many of the scenarios within the game are taken from factual RAMP experiences. To date, only the PC platform (or a Mac running PC emulator software) is available for use, but we hope to move to other platforms (e.g., Xbox 360, iPad, iPhone) as they become available. The game is written in programming language C# using Microsoft XNA and Visual Studio 2010, graphic shading is added using High Level Shader Language (HLSL), and rendering is produced using XNA's graphics libraries. Key elements of the game include selecting sensor locations, adequately installing the sensor, and monitoring the incoming data. During game play aftershocks can occur unexpectedly, as can other problems that require attention (e.g., power outages, equipment failure, and theft). The player accrues points for quickly deploying the first sensor (recording as many initial aftershocks as possible), correctly installing the sensors (orientation with respect to north, properly securing, and testing), distributing the sensors adequately in the region, and troubleshooting problems. One can also net points for efficient use of game play time. Setting up for game play in your local environment requires: (1) the Kinect hardware ( $145); (2) a computer

  5. Potential of multispectral imaging technology for rapid and non-destructive determination of the microbiological quality of beef filets during aerobic storage

    DEFF Research Database (Denmark)

    Panagou, Efstathios Z.; Papadopoulou, Olga; Carstensen, Jens Michael


    samples and correlated with microbiological data (log counts), for total viable counts (TVCs), Pseudomonas spp., and Brochothrix thermosphacta. Qualitative analysis (PLS-DA) was employed for the discrimination of meat samples in three microbiological quality classes based on the values of total viable....... thermosphacta, and TVC, respectively. The results indicated that multispectral vision technology has significant potential as a rapid and non-destructive technique in assessing the microbiological quality of beef fillets....


    A demonstration of screening technologies for determining the presence of dioxin and dioxin-like compounds in soil and sediment was conducted under the U.S. Environmental Protection Agency's(EPA's) Superfund Innovative Technology Evaluation Program in Saginaw, Michigan in 2004. T...

  7. Development of new-type rapid analysis technology of polychlorinated biphenyls by using liquid chromatographic clean-up material (polyvinyl alcohol gel). (United States)

    Sawatsubashi, Tetsuya; Tsukahara, Chisato; Baba, Keigo; Ohi, Etsumasa; Shinoda, Akiko; Miura, Norio


    We developed a new-type rapid polychlorinated biphenyl (PCB) analysis technology on the basis of a liquid chromatographic clean-up system combined with a large-volume injection GC-LRMS. Among 18 kinds of materials such as polymer gels, normal-phase silica gels, reversed-phase silica gels, carbon material and ion-exchange material, polyvinyl alcohol (PVA) gel and poly (hydroxylmethacrylate) gel were found to give rather good separation performance for insulating oil. Especially, PVA gel was confirmed to be the most suitable for rapid PCB analysis because of its least required quantity of fraction liquid as well as the highest resolution. Then, we confirmed elution characteristics of all PCB isomers and removal efficiency of insulating oil on PVA gel under an optimized condition, and established high-performance clean-up system using a combination of octadecyl silica gel (ODS), porous graphite carbon (PGC) and PVA gel. In this system, we applied newly valve-switching method that could remove other impurities. In addition, it was demonstrated that the proposed clean-up system could become highly sensitive and rapid PCB analysis technology with 2-h analysis time, lower measurement limit of less than 0.05 mg/kg, and a variation coefficient of less than 5%, by coupling with a large-volume injection type GC-LRMS. Thus, we can conclude that this rapid PCB analysis technology has not only good correlativity (R2>0.999) with standard analysis method but also high durability and can be fully applied to actual PCB-treatment plants.

  8. Thrombus-Targeted Theranostic Microbubbles: A New Technology towards Concurrent Rapid Ultrasound Diagnosis and Bleeding-free Fibrinolytic Treatment of Thrombosis. (United States)

    Wang, Xiaowei; Gkanatsas, Yannik; Palasubramaniam, Jathushan; Hohmann, Jan David; Chen, Yung Chih; Lim, Bock; Hagemeyer, Christoph E; Peter, Karlheinz


    Myocardial infarction and stroke are leading causes of morbidity/mortality. The typical underlying pathology is the formation of thrombi/emboli and subsequent vessel occlusion. Systemically administered fibrinolytic drugs are the most effective pharmacological therapy. However, bleeding complications are relatively common and this risk as such limits their broader use. Furthermore, a rapid non-invasive imaging technology is not available. Thereby, many thrombotic events are missed or only diagnosed when ischemic damage has already occurred. Design and preclinical testing of a novel 'theranostic' technology for the rapid non-invasive diagnosis and effective, bleeding-free treatment of thrombosis. A newly created, innovative theranostic microbubble combines a recombinant fibrinolytic drug, an echo-enhancing microbubble and a recombinant thrombus-targeting device in form of an activated-platelet-specific single-chain antibody. After initial in vitro proof of functionality, we tested this theranostic microbubble both in ultrasound imaging and thrombolytic therapy using a mouse model of ferric-chloride-induced thrombosis in the carotid artery. We demonstrate the reliable highly sensitive detection of in vivo thrombi and the ability to monitor their size changes in real time. Furthermore, these theranostic microbubbles proofed to be as effective in thrombolysis as commercial urokinase but without the prolongation of bleeding time as seen with urokinase. We describe a novel theranostic technology enabling simultaneous diagnosis and treatment of thrombosis, as well as monitoring of success or failure of thrombolysis. This technology holds promise for major progress in rapid diagnosis and bleeding-free thrombolysis thereby potentially preventing the often devastating consequences of thrombotic disease in many patients.

  9. Rapid hydrolysis of proteins and peptides by means of microwave technology and its application to amino acid analysis. (United States)

    Chen, S T; Chiou, S H; Chu, Y H; Wang, K T


    A rapid heating method of hydrolysis by the use of microwave oven has been applied to amino acid analysis of proteins and peptides. This convenient method has been compared with the conventional 6 N HCl hydrolysis at 110 degrees for 24 h. The advantages of this new method are its expedition and the accurate and comparable results as compared to the tedious conventional technique. The method provides a rapid processing of multiple samples within minutes instead of days and inexpensive access to the important data of amino acid compositions of proteins by the commonly used microwave oven. The necessary change in the design of hydrolysis vials and the safety precautions accompanying this novel use of microwave acid-digestion method are also described.

  10. Rapid multiplex detection of 10 foodborne pathogens with an up-converting phosphor technology-based 10-channel lateral flow assay. (United States)

    Zhao, Yong; Wang, Haoran; Zhang, Pingping; Sun, Chongyun; Wang, Xiaochen; Wang, Xinrui; Yang, Ruifu; Wang, Chengbin; Zhou, Lei


    The rapid high-throughput detection of foodborne pathogens is essential in controlling food safety. In this study, a 10-channel up-converting phosphor technology-based lateral flow (TC-UPT-LF) assay was established for the rapid and simultaneous detection of 10 epidemic foodborne pathogens. Ten different single-target UPT-LF strips were developed and integrated into one TC-UPT-LF disc with optimization. Without enrichment the TC-UPT-LF assay had a detection sensitivity of 10(4) CFU mL(-1) or 10(5) CFU mL(-1) for each pathogen, and after sample enrichment it was 10 CFU/0.6 mg. The assay also showed good linearity, allowing quantitative detection, with a linear fitting coefficient of determination (R(2)) of 0.916-0.998. The 10 detection channels did not cross-react, so multiple targets could be specifically detected. When 279 real food samples were tested, the assay was highly consistent (100%) with culture-based methods. The results for 110 food samples artificially contaminated with single or multiple targets showed a high detection rate (≥ 80%) for most target bacteria. Overall, the TC-UPT-LF assay allows the rapid, quantitative, and simultaneous detection of 10 kinds of foodborne pathogens within 20 min, and is especially suitable for the rapid detection and surveillance of foodborne pathogens in food and water.

  11. Prospective assessment of FilmArray® technology for the rapid identification of yeast isolated from blood cultures. (United States)

    Desoubeaux, Guillaume; Franck-Martel, Claire; Bailly, Éric; Le Brun, Cécile; Gyan, Emmanuel; Goudeau, Alain; Chandenier, Jacques; Lanotte, Philippe


    We prospectively assessed the ability of FilmArray® device to identify fungal species involved in bloodstream infections. It succeeded in identifying 85.7% of isolates. The automated readout of results enabled the rapid initiation of appropriate antifungal therapy. Thus, FilmArray® appeared as a reliable alternative diagnostic method for the most common yeast-like species. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Removal of organic matter from surface water during coagulation with sludge flotation and rapid filtration - a full-scale technological investigation. (United States)

    Pruss, Alina


    Coagulation with sludge flotation and rapid filtration was selected as a surface water treatment technology to be optimised with a full-scale investigation, which was carried out in Poland between August and October 2013. The river water treated was characterized by low alkalinity, high-temperature variability and a high organic matter content. In the course of technological studies, the processes of coagulation with sludge flotation and rapid filtration were analysed. The studies were performed in the most adverse conditions for the applied technology i.e. during the period of algal bloom and subsequent decomposition of dead plankton. Throughout the study, the river water contained mainly dissolved organic matter, with occasional increases in the concentration of the undissolved fraction during algal bloom. The undissolved total organic carbon (TOC) fraction was effectively removed through coagulation while small doses of ClO₂added prior to coagulation enhanced the process. The process of coagulation using high-coagulant doses at pH = 6.5 did not provide a reduction in the TOC value below the level of 4 mg C/L required for treated water. The effect was achieved by adding powdered activated carbon (PAC) before the filters. The coagulation products were characterised by low-hydraulic resistance which should be taken into account at the stage of water delivery to the filters, after flotation.

  13. Acceptability Among Community Healthcare Nurses of Intelligent Wireless Sensor-system Technology for the Rapid Detection of Health Issues in Home-dwelling Older Adults. (United States)

    Cohen, Christine; Kampel, Thomas; Verloo, Henk


    The effective care and support of community healthcare nurses (CHNs) contribute greatly to the healthy aging of older adults living at home. Integrating innovative technologies into CHNs' daily practice offers new opportunities and perspectives for early detection of health issues and interventions among home-dwelling older adults. To explore the perception of acceptability among CHNs of an intelligent wireless sensor system (IWSS) for use in daily practice for the detection of health issues in home-dwelling older adults receiving home healthcare. Descriptive and qualitative data were sourced from a pilot randomized controlled trial involving 17 CHNs using an IWSS in their daily practice to rapidly detect falls and other health issues in patients' homes. IWSS alerts indicating behavior changes were sent to CHNs. Their perceived usefulness (PU) and perceived ease of use (PEOU) were assessed. The acceptability of IWSS technology was explored using a questionnaire and focus group discussions. The PU and PEOU of the IWSS technology were low to moderate. A majority of the CHNs were dissatisfied with its performance and intrusiveness; they reported multiple obstacles in the usefulness and ease of use of the IWSS technology in daily practice. To improve the IWSS technology's low to moderate acceptability among CHNs, we recommend a more user-centered implementation strategy and an embedded model of nursing care.

  14. A rapid method for alpha-spectrometric analysis of radium isotopes in natural waters using ion-selective membrane technology. (United States)

    Purkl, Stefan; Eisenhauer, Anton


    An alpha-spectrometric method for the rapid determination of radium isotopes (223Ra, 224Ra and 226Ra) in environmental samples is presented. Using Empore Radium Rad Disks complete separation of the target radionuclides is achieved. The high selectivity of these Rad Disks allows the straightforward use of 225Ra as yield tracer. Chemical yield is up to 92 +/- 9%. The chemical procedure can be accomplished within 5h. Alpha-sources show energy resolution in the range of typically 26-40 keV (FWHM). Despite minimal thickness of the sources no significant radon (Rn) losses can be observed.

  15. Impact of experience when using the Rapid Upper Limb Assessment to assess postural risk in children using information and communication technologies. (United States)

    Chen, Janice D; Falkmer, Torbjörn; Parsons, Richard; Buzzard, Jennifer; Ciccarelli, Marina


    The Rapid Upper Limb Assessment (RULA) is an observation-based screening tool that has been used to assess postural risks of children in school settings. Studies using eye-tracking technology suggest that visual search strategies are influenced by experience in the task performed. This study investigated if experience in postural risk assessments contributed to differences in outcome scores on the RULA and the visual search strategies utilized. While wearing an eye-tracker, 16 student occupational therapists and 16 experienced occupational therapists used the RULA to assess 11 video scenarios of a child using different mobile information and communication technologies (ICT) in the home environment. No significant differences in RULA outcome scores, and no conclusive differences in visual search strategies between groups were found. RULA can be used as a screening tool for postural risks following a short training session regardless of the assessor's experience in postural risk assessments. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  16. Rapid single-tube method for small-scale affinity purification of polyclonal antibodies using HaloTag Technology. (United States)

    Hata, Toshiyuki; Nakayama, Manabu


    Even in this era of advanced biotechniques, specific antibodies against a protein still prove to be powerful tools to study proteins and their functions. The polyclonal antisera obtained from the immunized rabbits, however, are not always pure, high affinity, antigen-specific polyclonal antibodies. With our new rapid HaloTag-based procedure, specific antibodies are obtained in just two, short steps: (1) simultaneous purification and covalent coupling of the antigen to Sepharose resin via the HaloTag and HaloLink reaction, and (2) affinity column purification of the polyclonal serum (10 microl). The combined antigen purification and coupling step requires only 1 h of room-temperature incubation, plus successive washing steps. Because different regions of an antigen can elicit the production of low affinity antibodies with relatively high cross-reactivity, the best way to produce high affinity antibodies against a protein of interest is to survey all antigenic determinants of that protein and identify the epitopes that result in the production of antibodies with a high affinity and specificity for that protein. Because our HaloTag procedure is quite rapid and simple, potential epitopes can be assessed with relatively little effort for their ability to elicit the production of highly specific antibodies.

  17. Materials Research Society Symposium Proceedings, Volume 758 Held in Boston, Massachusetts on December 3-5, 2002. Rapid Prototyping Technologies (United States)


    BioMEMS and Bionanotechnology, L.P. Lee, J.T. Borenstein, R.P. Manginell, M. Okandan, P.J. Hesketh, 2002, ISBN: 1-55899-665-6 Volume 730- Materials for... INTRODUCTION Microstereolithography is the general designation of various microfabrication technologies based on the principle used in stereolithography, For Direct Metal Laser Sintering (DMLS) this was enabled by the introduction of the powders for 20 micron layer thickness; steel-based powder in


    Directory of Open Access Journals (Sweden)

    A. S. Kalinichenko


    Full Text Available The variety of requirements for friction pairs requires the development of different technologies for the production of tribological materials with reference to the operation modes. Composite materials obtained by the casting technology have been successfully applied for the normalization of the thermomechanical state of the steam turbines. These composites consist of the matrix based on copper alloys reinforced with cast iron granules. Because the structure and properties of cast iron are determined by the conditions of their production studies have been conducted on determination of preparation conditions on grain structure and properties of the synthesized composite material. Using an upgraded unit for production of granules technological regimes were determined providing narrow fractional composition. It has been found that granules formed are characterized with typical microstructure of white cast iron containing perlite and ledeburite. Microhardness of pilot cast iron granules is characterized by high values (from 7450 up to 9450 MPa and depends on the size of the fraction. Composite materials obtained using experimental granules had a microhardness of the reinforcing cast iron granules about 3500 MPa, and a bronze matrix – 1220 MPa, which is higher than the hardness of the composite material obtained by using the annealed DCL-1granules (2250 MPa. Metal base of experimental granules in the composite material has the structure of perlitic ductile iron with inclusions of ferrite not exceeding 10–15% and set around a flocculent graphite. As a result, the increase of physical-mechanical properties of finished products made of composite material is observed. 

  19. Rapid Solid-Phase Immunoassay for Detection of Methicillin-Resistant Staphylococcus aureus Using Cycling Probe Technology


    Fong, Whalley K.; Modrusan, Zora; McNevin, John P.; Marostenmaki, Johanna; Zin, Ben; Bekkaoui, Faouzi


    A Cycling Probe Technology (CPT) assay with a lateral-flow device (strip) was developed for the detection of the mecA gene from methicillin-resistant Staphylococcus aureus (MRSA) cultures. The assay uses a mecA probe (DNA-RNA-DNA) labeled with fluorescein at the 5′ terminus and biotin at the 3′ terminus. The CPT reaction occurs at a constant temperature, which allows the probe to anneal to the target DNA. RNase H cuts the RNA portion of the probe, allowing the cleaved fragments to dissociate ...

  20. A Rapid Screening Analysis of Antioxidant Compounds in Native Australian Food Plants Using Multiplexed Detection with Active Flow Technology Columns

    Directory of Open Access Journals (Sweden)

    Emmanuel Janaka Rochana Rupesinghe


    Full Text Available Conventional techniques for identifying antioxidant and phenolic compounds in native Australian food plants are laborious and time-consuming. Here, we present a multiplexed detection technique that reduces analysis time without compromising separation performance. This technique is achieved using Active Flow Technology-Parallel Segmented Flow (AFT-PSF columns. Extracts from cinnamon myrtle (Backhousia myrtifolia and lemon myrtle (Backhousia citriodora leaves were analysed via multiplexed detection using an AFT-PSF column with underivatised UV-VIS, mass spectroscopy (MS, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH• derivatisation for antioxidants as detection methods. A number of antioxidant compounds were detected in the extracts of each leaf extract.

  1. Clinical Application of Picodroplet Digital PCR Technology for Rapid Detection of EGFR T790M in Next-Generation Sequencing Libraries and DNA from Limited Tumor Samples. (United States)

    Borsu, Laetitia; Intrieri, Julie; Thampi, Linta; Yu, Helena; Riely, Gregory; Nafa, Khedoudja; Chandramohan, Raghu; Ladanyi, Marc; Arcila, Maria E


    Although next-generation sequencing (NGS) is a robust technology for comprehensive assessment of EGFR-mutant lung adenocarcinomas with acquired resistance to tyrosine kinase inhibitors, it may not provide sufficiently rapid and sensitive detection of the EGFR T790M mutation, the most clinically relevant resistance biomarker. Here, we describe a digital PCR (dPCR) assay for rapid T790M detection on aliquots of NGS libraries prepared for comprehensive profiling, fully maximizing broad genomic analysis on limited samples. Tumor DNAs from patients with EGFR-mutant lung adenocarcinomas and acquired resistance to epidermal growth factor receptor inhibitors were prepared for Memorial Sloan-Kettering-Integrated Mutation Profiling of Actionable Cancer Targets sequencing, a hybrid capture-based assay interrogating 410 cancer-related genes. Precapture library aliquots were used for rapid EGFR T790M testing by dPCR, and results were compared with NGS and locked nucleic acid-PCR Sanger sequencing (reference high sensitivity method). Seventy resistance samples showed 99% concordance with the reference high sensitivity method in accuracy studies. Input as low as 2.5 ng provided a sensitivity of 1% and improved further with increasing DNA input. dPCR on libraries required less DNA and showed better performance than direct genomic DNA. dPCR on NGS libraries is a robust and rapid approach to EGFR T790M testing, allowing most economical utilization of limited material for comprehensive assessment. The same assay can also be performed directly on any limited DNA source and cell-free DNA. Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  2. Updates on the Construction of an Eyeglass-Supported Nasal Prosthesis Using Computer-Aided Design and Rapid Prototyping Technology. (United States)

    Ciocca, Leonardo; Tarsitano, Achille; Marchetti, Claudio; Scotti, Roberto


    This study was undertaken to design an updated connection system for an eyeglass-supported nasal prosthesis using rapid prototyping techniques. The substructure was developed with two main endpoints in mind: the connection to the silicone and the connection to the eyeglasses. The mold design was also updated; the mold was composed of various parts, each carefully designed to allow for easy release after silicone processing and to facilitate extraction of the prosthesis without any strain. The approach used in this study enabled perfect transfer of the reciprocal position of the prosthesis with respect to the eyeglasses, from the virtual to the clinical environment. Moreover, the reduction in thickness improved the flexibility of the prosthesis and promoted adaptation to the contours of the skin, even during functional movements. The method described here is a simplified and viable alternative to standard construction techniques for nasal prostheses and offers improved esthetic and functional results when no bone is available for implant-supported prostheses. © 2015 by the American College of Prosthodontists.

  3. Making our data impactful: Working with researchers to meet diverse data needs in a rapidly shifting technological world. (United States)

    Laney, C. M.


    Making data easily accessible and actionable is critical in our drive to understand ecological drivers and responses in our rapidly changing world. The National Ecological Observatory Network (NEON), operated by Battelle and sponsored by the National Science Foundation, is a continental-scale, long-term observation facility built specifically to meet such needs. By the end of construction at the end of 2017, NEON will be generating and synthesizing data from in situ instruments, field sampling, and airborne platforms covering 81 field sites across the U.S. A challenge of such observatories is not only to generate, quality-control, and synthesize enormous and high-resolution datasets, but to provide it freely to researchers in formats that are easy to understand and integrate with other datasets. Here, we present how NEON is preparing publication-ready data for ready reuse by a broad range of practitioners through numerous mechanisms: 1) developing a robust and intuitive data portal and public API, 2) collaborating with numerous partners to support and enrich standards to assure interoperability and reproducibility, and 3) providing training materials covering the key concepts and tools researchers may need to fully leverage NEON data. In addition, we will solicit feedback on NEON's current, in-design, and proposed data services and portal features in order to best serve the diverse research interests of a AGU's scientific community.

  4. Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies. (United States)

    Xie, Hongwei; Chakraborty, Asish; Ahn, Joomi; Yu, Ying Qing; Dakshinamoorthy, Deepalakshmi P; Gilar, Martin; Chen, Weibin; Skilton, St John; Mazzeo, Jeffery R


    This study shows that state-of-the-art liquid chromatography (LC) and mass spectrometry (MS) can be used for rapid verification of identity and characterization of sequence variants and posttranslational modifications (PTMs) for antibody products. A candidate biosimilar IgG1 monoclonal antibody (mAb) was compared in detail to a commercially available innovator product. Intact protein mass, primary sequence, PTMs, and the micro-differences between the two mAbs were identified and quantified simultaneously. Although very similar in terms of sequences and modifications, a mass difference observed by LC-MS intact mass measurements indicated that they were not identical. Peptide mapping, performed with data independent acquisition LC-MS using an alternating low and elevated collision energy scan mode (LC-MS(E)), located the mass difference between the biosimilar and the innovator to a two amino acid residue variance in the heavy chain sequences. The peptide mapping technique was also used to comprehensively catalogue and compare the differences in PTMs of the biosimilar and innovator mAbs. Comprehensive glycosylation profiling confirmed that the proportion of individual glycans was different between the biosimilar and the innovator, although the number and identity of glycans were the same. These results demonstrate that the combination of accurate intact mass measurement, released glycan profiling, and LC-MS(E) peptide mapping provides a set of routine tools that can be used to comprehensively compare a candidate biosimilar and an innovator mAb.

  5. Invert biopanning: A novel method for efficient and rapid isolation of scFvs by phage display technology. (United States)

    Rahbarnia, Leila; Farajnia, Safar; Babaei, Hossein; Majidi, Jafar; Veisi, Kamal; Tanomand, Asghar; Akbari, Bahman


    Phage display is a prominent screening technique for development of novel high affinity antibodies against almost any antigen. However, removing false positive clones in screening process remains a challenge. The aim of this study was to develop an efficient and rapid method for isolation of high affinity scFvs by removing NSBs without losing rare specific clones. Therefore, a novel two rounds strategy called invert biopanning was developed for isolating high affinity scFvs against EGFRvIII antigen from human scFv library. The efficiency of invert biopanning method (procedure III) was analyzed by comparing with results of conventional biopanning methods (procedures I and II). According to the results of polyclonal ELISA, the second round of procedure III displayed highest binding affinity against EGFRvIII peptide accompanied by lowest NSB comparing to other two procedures. Several positive clones were identified among output phages of procedure III by monoclonal phage ELISA which displayed high affinity to EGFRvIII antigen. In conclusion, results of our study indicate that invert biopanning is an efficient method for avoiding NSBs and conservation of rare specific clones during screening of a scFv phage library. Novel anti EGFRvIII scFv isolated could be a promising candidate for potential use in treatment of EGFRvIII expressing cancers. Copyright © 2016 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

  6. Rapid access to compound libraries through flow technology: fully automated synthesis of a 3-aminoindolizine library via orthogonal diversification. (United States)

    Lange, Paul P; James, Keith


    A novel methodology for the synthesis of druglike heterocycle libraries has been developed through the use of flow reactor technology. The strategy employs orthogonal modification of a heterocyclic core, which is generated in situ, and was used to construct both a 25-membered library of druglike 3-aminoindolizines, and selected examples of a 100-member virtual library. This general protocol allows a broad range of acylation, alkylation and sulfonamidation reactions to be performed in conjunction with a tandem Sonogashira coupling/cycloisomerization sequence. All three synthetic steps were conducted under full automation in the flow reactor, with no handling or isolation of intermediates, to afford the desired products in good yields. This fully automated, multistep flow approach opens the way to highly efficient generation of druglike heterocyclic systems as part of a lead discovery strategy or within a lead optimization program.

  7. Guidelines for the selection of appropriate remote sensing technologies for landslide detection, monitoring and rapid mapping: the experience of the SafeLand European Project. (United States)

    Stumpf, A.; Malet, J.-P.; Kerle, N.; Tofani, V.; Segoni, S.; Casagli, N.; Michoud, C.; Jaboyedoff, M.; Fornaro, G.; Peduto, D.; Cascini, L.; Baron, I.; Supper, R.; Oppikofer, T.; L'Heureux, J.-S.; Van Den Eeckhaut, M.; Hervás, J.; Moya, J.; Raucoules, D.; Carman, M.


    New earth observation satellites, innovative airborne platforms and sensors, high precision laser scanners, and enhanced ground-based geophysical investigation tools are a few examples of the increasing diversity of remote sensing technologies used in landslide analysis. The use of advanced sensors and analysis methods can help to significantly increase our understanding of potentially hazardous areas and helps to reduce associated risk. However, the choice of the optimal technology, analysis method and observation strategy requires careful considerations of the landslide process in the local and regional context, and the advantages and limitations of each technique. Guidelines for the selection of the most suitable remote sensing technologies according to different landslide types, displacement velocities, observational scales and risk management strategies have been proposed. The guidelines are meant to aid operational decision making, and include information such as spatial resolution and coverage, data and processing costs, and maturity of the method. The guidelines target scientists and end-users in charge of risk management, from the detection to the monitoring and the rapid mapping of landslides. They are illustrated by recent innovative methodologies developed for the creation and updating of landslide inventory maps, for the construction of landslide deformation maps and for the quantification of hazard. The guidelines were compiled with contributions from experts on landslide remote sensing from 13 European institutions coming from 8 different countries. This work is presented within the framework of the SafeLand project funded by the European Commission's FP7 Programme.

  8. Review of thermal recovery technologies for the Clearwater and lower Grand Rapids formations in the Cold Lake area in Alberta

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Q.; Thornton, B.; Houston, J.R.; Spence, S. [OSUM Oil Sands Corp., Calgary, AB (Canada)


    This paper described a performance review conducted to assess steam assisted gravity drainage (SAGD) and cyclic steam stimulation (CSS) projects in the Cold Lake region. Commercial and pilot plant projects in the region were discussed. The aim of the study was to design a development plan for achieving bitumen production rates of 35,000 barrels per day in the Taiga region. While relatively high pressure drawdowns are created between the wellbore and formation during CSS production phases, the CSS process has limited applications in fine grain sands reservoirs, or in reservoirs with thick bottom water. SAGD processes require a minimum pressure drawdown to drive reservoir fluids to the wellbore, making them ideal for reservoirs with top gas, or in formations with fine grain sands and bottom water. Selection criteria for CSS and SAGD technologies were reviewed. Simulations were conducted to assess the impacts of well placement, reservoir heterogeneity, and operating parameters on SAGD and CSS performance. Well configurations for optimal SAGD performance were also presented. 19 refs., 3 tabs., 20 figs.

  9. Optimizing patient treatment decisions in an era of rapid technological advances: the case of hepatitis C treatment. (United States)

    Liu, Shan; Brandeau, Margaret L; Goldhaber-Fiebert, Jeremy D


    How long should a patient with a treatable chronic disease wait for more effective treatments before accepting the best available treatment? We develop a framework to guide optimal treatment decisions for a deteriorating chronic disease when treatment technologies are improving over time. We formulate an optimal stopping problem using a discrete-time, finite-horizon Markov decision process. The goal is to maximize a patient's quality-adjusted life expectancy. We derive structural properties of the model and analytically solve a three-period treatment decision problem. We illustrate the model with the example of treatment for chronic hepatitis C virus (HCV). Chronic HCV affects 3-4 million Americans and has been historically difficult to treat, but increasingly effective treatments have been commercialized in the past few years. We show that the optimal treatment decision is more likely to be to accept currently available treatment-despite expectations for future treatment improvement-for patients who have high-risk history, who are older, or who have more comorbidities. Insights from this study can guide HCV treatment decisions for individual patients. More broadly, our model can guide treatment decisions for curable chronic diseases by finding the optimal treatment policy for individual patients in a heterogeneous population.

  10. Rapid identification of pearl powder from Hyriopsis cumingii by Tri-step infrared spectroscopy combined with computer vision technology (United States)

    Liu, Siqi; Wei, Wei; Bai, Zhiyi; Wang, Xichang; Li, Xiaohong; Wang, Chuanxian; Liu, Xia; Liu, Yuan; Xu, Changhua


    Pearl powder, an important raw material in cosmetics and Chinese patent medicines, is commonly uneven in quality and frequently adulterated with low-cost shell powder in the market. The aim of this study is to establish an adequate approach based on Tri-step infrared spectroscopy with enhancing resolution combined with chemometrics for qualitative identification of pearl powder originated from three different quality grades of pearls and quantitative prediction of the proportions of shell powder adulterated in pearl powder. Additionally, computer vision technology (E-eyes) can investigate the color difference among different pearl powders and make it traceable to the pearl quality trait-visual color categories. Though the different grades of pearl powder or adulterated pearl powder have almost identical IR spectra, SD-IR peak intensity at about 861 cm- 1 (v2 band) exhibited regular enhancement with the increasing quality grade of pearls, while the 1082 cm- 1 (v1 band), 712 cm- 1 and 699 cm- 1 (v4 band) were just the reverse. Contrastly, only the peak intensity at 862 cm- 1 was enhanced regularly with the increasing concentration of shell powder. Thus, the bands in the ranges of (1550-1350 cm- 1, 730-680 cm- 1) and (830-880 cm- 1, 690-725 cm- 1) could be exclusive ranges to discriminate three distinct pearl powders and identify adulteration, respectively. For massive sample analysis, a qualitative classification model and a quantitative prediction model based on IR spectra was established successfully by principal component analysis (PCA) and partial least squares (PLS), respectively. The developed method demonstrated great potential for pearl powder quality control and authenticity identification in a direct, holistic manner.

  11. Rapid identification of pearl powder from Hyriopsis cumingii by Tri-step infrared spectroscopy combined with computer vision technology. (United States)

    Liu, Siqi; Wei, Wei; Bai, Zhiyi; Wang, Xichang; Li, Xiaohong; Wang, Chuanxian; Liu, Xia; Liu, Yuan; Xu, Changhua


    Pearl powder, an important raw material in cosmetics and Chinese patent medicines, is commonly uneven in quality and frequently adulterated with low-cost shell powder in the market. The aim of this study is to establish an adequate approach based on Tri-step infrared spectroscopy with enhancing resolution combined with chemometrics for qualitative identification of pearl powder originated from three different quality grades of pearls and quantitative prediction of the proportions of shell powder adulterated in pearl powder. Additionally, computer vision technology (E-eyes) can investigate the color difference among different pearl powders and make it traceable to the pearl quality trait-visual color categories. Though the different grades of pearl powder or adulterated pearl powder have almost identical IR spectra, SD-IR peak intensity at about 861cm-1 (v2 band) exhibited regular enhancement with the increasing quality grade of pearls, while the 1082cm-1 (v1 band), 712cm-1 and 699cm-1 (v4 band) were just the reverse. Contrastly, only the peak intensity at 862cm-1 was enhanced regularly with the increasing concentration of shell powder. Thus, the bands in the ranges of (1550-1350cm-1, 730-680cm-1) and (830-880cm-1, 690-725cm-1) could be exclusive ranges to discriminate three distinct pearl powders and identify adulteration, respectively. For massive sample analysis, a qualitative classification model and a quantitative prediction model based on IR spectra was established successfully by principal component analysis (PCA) and partial least squares (PLS), respectively. The developed method demonstrated great potential for pearl powder quality control and authenticity identification in a direct, holistic manner. Copyright © 2017. Published by Elsevier B.V.

  12. Rapid identification of Candida spp. frequently involved in invasive mycoses by using flow-through hybridization and Gene Chip (FHGC) technology. (United States)

    Li, Chen; Ding, Xiurong; Liu, Zhizhong; Zhu, Juanjuan


    The incidence of invasive fungal infections in immunocompromised patients has increased in recent decades. Rapid and accurate identification of these pathogenic fungi is crucial for initiating a timely, safe, and effective antifungal therapy. Here we developed a microarray based on flow-through hybridization gene chip technology. The microarray was tested for its specificity using a panel of reference and blinded clinical isolates. The results proved that this microarray was highly discriminative, leading to the unequivocal identification of each species, including Candida famata and the highly related species Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis. This new system represents a reliable method that is of potential use in clinical laboratories for the simultaneous detection and identification of the most common pathogenic fungi. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Development and evaluation of an up-converting phosphor technology-based lateral flow assay for rapid and quantitative detection of aflatoxin B1 in crops. (United States)

    Zhao, Yong; Liu, Xiao; Wang, Xiaochen; Sun, Chongyun; Wang, Xinrui; Zhang, Pingping; Qiu, Jingfu; Yang, Ruifu; Zhou, Lei


    Contamination of grains and other crops by aflatoxin B1 (AFB1), a highly toxic aflatoxin produced by Aspergillus flavus and Aspergillus parasiticus, poses a serious threat to human health and is an important food safety issue. In this study, a competitive up-converting phosphor technology-based lateral flow (AFB1-UPT-LF) assay was developed for rapid detection of AFB1. Detection sensitivity of the proposed assay can reach 0.03ngmL -1 for standard AFB1 solutions, with the coefficients of variation (CV) less than 10% (from 1.0 to 9.4%). A good linearity (r=0.9889) was observed for quantification of AFB1 from 0.03 to 1000ngmL -1 . Except for aflatoxin M1, no cross-reactivity was found with the abrin, ricin, ochratoxin A, botulinum toxin, shiga toxin 1, shiga toxin 2, and staphylococcal enterotoxin B, even at high concentrations of 100 or 1000ngmL - 1 . After optimizing the extraction of AFB1, the assay showed good tolerance to various crop samples, with the detection limit (from 0.1 to 5ngg - 1 ) lower than the corresponding maximum residue level (MRL) set in China. The AFB1-UPT-LF assay provides a promising tool for rapid on-site detection of AFB1 because of its high sensitivity, specificity, and sample tolerance. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Integrated Use of Tools and Technologies for Rapidly Prototyping Simulated Data Products of Future NASA Observing Systems For Evaluation in Applications of National Importance (United States)

    O'Hara, C. G.; Moorhead, R.; Shaw, D.; Shrestha, B.; Ross, K.; Prados, D.; Russell, J.; Ryan, R. E.


    NASA sponsored "Rapid Prototyping Capability" (RPC) research activities of the Mississippi Research Consortium are aimed at developing infrastructure and experiments to evaluate data products from future NASA observing systems in applications, models or decision support tools of national importance. The RPC will host a wide variety of experiments, many of which will require the simulation of data streams to approximate products from future NASA observing systems. To simulate data from a future observing system, a variety of tools and technologies must be employed in an integrated computational workflow. Future data product simulations will typically involve using data products from currently operational science data mission observing systems to provide inputs to a process wherein data will be extracted and manipulated to provide products that approximate the spectral, spatial, radiometric, and temporal characteristics of planned future sensors. The integration of tools and technologies and adapting interfaces for ease of use will enable researchers to test a variety of simulations to efficiently determine an acceptable set of procedures whereby a simulated data product may be derived from existing data sources. Interactive research and testing of data product simulation scenarios will strongly leverage NASA tools and technologies such as the HDF Extraction to GeoTiff tool (HEG2.7) to extract large volumes of data in batch mode, the Time-Series Product Toolkit (TSPT) to evaluate methods for data fusion, de-noising, and creating multi-temporal composites, and the Application Research Toolbox (ART) to manipulate data product characteristics in the simulation process. Given an accepted simulation configuration generated by a set of methods and a documented process workflow, the process will be computationally implemented using Mississippi State University's Temporal Map Algebra (TMA) tools which will enable handling large data sets, computing efficiently the desired

  15. Adapting a Markov Monte Carlo simulation model for forecasting the number of coronary artery revascularisation procedures in an era of rapidly changing technology and policy. (United States)

    Mannan, Haider R; Knuiman, Matthew; Hobbs, Michael


    Treatments for coronary heart disease (CHD) have evolved rapidly over the last 15 years with considerable change in the number and effectiveness of both medical and surgical treatments. This period has seen the rapid development and uptake of statin drugs and coronary artery revascularization procedures (CARPs) that include Coronary Artery Bypass Graft procedures (CABGs) and Percutaneous Coronary Interventions (PCIs). It is difficult in an era of such rapid change to accurately forecast requirements for treatment services such as CARPs. In a previous paper we have described and outlined the use of a Markov Monte Carlo simulation model for analyzing and predicting the requirements for CARPs for the population of Western Australia (Mannan et al, 2007). In this paper, we expand on the use of this model for forecasting CARPs in Western Australia with a focus on the lack of adequate performance of the (standard) model for forecasting CARPs in a period during the mid 1990s when there were considerable changes to CARP technology and implementation policy and an exploration and demonstration of how the standard model may be adapted to achieve better performance. Selected key CARP event model probabilities are modified based on information relating to changes in the effectiveness of CARPs from clinical trial evidence and an awareness of trends in policy and practice of CARPs. These modified model probabilities and the ones obtained by standard methods are used as inputs in our Markov simulation model. The projected numbers of CARPs in the population of Western Australia over 1995-99 only improve marginally when modifications to model probabilities are made to incorporate an increase in effectiveness of PCI procedures. However, the projected numbers improve substantially when, in addition, further modifications are incorporated that relate to the increased probability of a PCI procedure and the reduced probability of a CABG procedure stemming from changed CARP preference

  16. A novel generic dipstick-based technology for rapid and precise detection of tetracycline, streptogramin and macrolide antibiotics in food samples. (United States)

    Link, Nils; Weber, Wilfried; Fussenegger, Martin


    Excessive use of antibiotics in veterinary medicine and as growth promoters in stock farming has been associated with the dramatically increasing prevalence of multidrug-resistant human pathogenic bacteria. European community legislators have therefore restricted the veterinary use of antibiotics and banned them as growth-promoting food additives in stock breeding (1831/2003/EC). The monitoring of such legislation requires technology for precise and straightforward on-site quantification of antibiotics in farm samples and food products without the need for extensive laboratory equipment and trained personnel. Capitalizing on bacterial transcriptional regulators (TetR, PIP, E), which are dose-dependently released from their cognate operators (tetO, PIR, ETR) upon binding of specific classes of antibiotics (tetracycline, streptogramins, macrolides) we have designed an easy-to-handle dipstick-based assay for detection of antibiotic levels in serum, meat and milk whose detection limits are up to 40-fold below licensed threshold values. The generic dipstick consists of either nitrocellulose, nylon or polyvinylidenfluorid (PVDF) membrane strips coated with streptavidin and immobilized biotinylated operator DNA, which acts as capture DNA to bind hexa-histidine (His(6))-tagged bacterial biosensors. Antibiotics present in specific samples triggered the dose-dependent release of the capture DNA-biosensor interaction, which, after dipping into two different solutions, results in a correlated conversion of a chromogenic substrate by a standard His(6)-targeted enzyme complex. This can be quantified by comparison of the dipstick to a standardized color scale or by assessing the terminal solution at 450nm. As demonstrated using serum, meat and milk samples spiked with 14 different antibiotics, the dipstick technology provided sensitive detection in a rapid assay format, and could be employed to monitor non-authorized use of antibiotics and to discover novel antibiotics.

  17. Rapid Robot Design Validation Project (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robotic designs. The software will support push-button validation...

  18. Rapid Robot Design Validation Project (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robot designs. The software will support push-button validation...

  19. [Development and comparative evaluation of up-converting phosphor technology based lateral flow assay for rapid detection of Yersinia pestis, Bacillus anthracis spore and Brucella spp]. (United States)

    Li, Chunfeng; Zhang, Pingping; Wang, Xiaoying; Liu, Xiao; Zhao, Yong; Sun, Chongyun; Wang, Chengbin; Yang, Ruifu; Zhou, Lei


    To develop an up-converting phosphor technology based lateral flow (UPT-LF) assay for rapid and quantitative detection of Yersinia pestis, Bacillus anthracis spore and Brucella spp.and make the comparison with BioThreat Alert (BTA) test strips (Tetracore Inc., USA). Using up-converting phosphor nano-particles (UCP-NPs) as the bio-marker, three double-antibody-sandwich model based UPT-LF strips including Plague-UPT-LF, Anthrax-UPT-LF, Brucella-UPT-LF were prepared and its sensitivity, accuracy, linearity and specificity were determined by detecting 10(10), 10(9), 10(8), 10(7), 10(6), 10(5) and 0 CFU/ml series of concentrations of Y.pestis, B.anthracis, Brucella standards and other 27 kinds of 10(9) CFU/ml series of contrations of bacteria strains.Furthermore, the speed, sensitivity and accuracy of bacteria standards and simulated sample detection were compared between UPT-LF and BTA system. The detection limit of Plague-UPT-LF, Anthrax-UPT-LF and Brucella-LF was 10(5) CFU/ml. The CV of series of bacteria concentrations was ≤ 15%, and the r between lg (T/C-cut-off) and lg (concentration) was 0.996,0.998 and 0.999 (F values were 1 647.57, 743.51 and 1 822.17. All the P values were Brucella-LF were excellent, while that of Anthrax-UPT-LF was a little bit regretful because of non-specific reaction with two isolates of B. subtilis and one B.cereus. On-site evaluation showed the detection time of UPT-LF for all Y.pestis, B.anthracis spore and Brucella spp.was 33, 36 and 37 min, while BTA was 115, 115 and 111 min, which revealed the higher detection speed and sensitivity of UPT-LF comparing with BTA. The negative rate of two methods for blank standard was both 5/5, the sensitivity of UPT-LF for Y.pestis,B.anthracis spore and Brucella spp. was all 10(5) CFU/ml, then BTA was 10(6), 10(6) and 10(5) CFU/ml, respectively. The detection rate of UPT-LF for all three bacteria analog positive samples was 16/16, while BTA for B.anthracis was 7/16 only. The good performance

  20. Evaluation of up-converting phosphor technology-based lateral flow strips for rapid detection of Bacillus anthracis Spore, Brucella spp., and Yersinia pestis.

    Directory of Open Access Journals (Sweden)

    Pingping Zhang

    Full Text Available Bacillus anthracis, Brucella spp., and Yersinia pestis are zoonotic pathogens and biowarfare- or bioterrorism-associated agents that must be detected rapidly on-site from various samples (e.g., viscera and powders. An up-converting phosphor technology-based lateral flow (UPT-LF strip was developed as a point-of-care testing (POCT to satisfy the requirements of first-level emergency response. We developed UPT-LF POCT to quantitatively detect the three pathogens within 15 min. Sample and operation-error tolerances of the assay were comprehensively evaluated. The sensitivity of UPT-LF assay to bacterial detection reached 10(4 cfu · mL(-1 (100 cfu/test, with a linear quantitative range of 4 to 6 orders of magnitude. Results revealed that the UPT-LF assay exhibited a high specificity with the absence of false-positive results even at 10(9 cfu · mL(-1 of non-specific bacterial contamination. The assay could tolerate samples with a wide pH range (2 to 12, high ion strengths (≥ 4 mol · L(-1 of NaCl, high viscosities (≤ 25 mg · mL(-1 of PEG20000 or ≥ 20% of glycerol, and high concentrations of bio-macromolecule (≤ 200 mg · mL(-1 of bovine serum albumin or ≥ 80 mg · mL(-1 of casein. The influence of various types of powders and viscera (fresh and decomposed on the performance of UPT-LF assay was determined. The operational error of liquid measurement exhibited few effects on sensitivity and specificity. The developed UPT-LF POCT assay is applicable under field conditions with excellent tolerance to sample complexity and operational error.

  1. Technology

    Directory of Open Access Journals (Sweden)

    Xu Jing


    Full Text Available The traditional answer card reading method using OMR (Optical Mark Reader, most commonly, OMR special card special use, less versatile, high cost, aiming at the existing problems proposed a method based on pattern recognition of the answer card identification method. Using the method based on Line Segment Detector to detect the tilt of the image, the existence of tilt image rotation correction, and eventually achieve positioning and detection of answers to the answer sheet .Pattern recognition technology for automatic reading, high accuracy, detect faster

  2. Rapid Prototyping Reconsidered (United States)

    Desrosier, James


    Continuing educators need additional strategies for developing new programming that can both reduce the time to market and lower the cost of development. Rapid prototyping, a time-compression technique adapted from the high technology industry, represents one such strategy that merits renewed evaluation. Although in higher education rapid…

  3. Rapid detection of health-care-associated bloodstream infection in critical care using multipathogen real-time polymerase chain reaction technology: a diagnostic accuracy study and systematic review. (United States)

    Warhurst, Geoffrey; Dunn, Graham; Chadwick, Paul; Blackwood, Bronagh; McAuley, Daniel; Perkins, Gavin D; McMullan, Ronan; Gates, Simon; Bentley, Andrew; Young, Duncan; Carlson, Gordon L; Dark, Paul


    antibiotic exposure. SeptiFast real-time PCR, when compared with culture-proven bloodstream infection at species/genus level, had better specificity (85.8%, 95% CI 83.3% to 88.1%) than sensitivity (50%, 95% CI 39.1% to 60.8%). When compared with pooled diagnostic metrics derived from our systematic review, our clinical study revealed lower test accuracy of SeptiFast real-time PCR, mainly as a result of low diagnostic sensitivity. There was a low prevalence of BC-proven pathogens in these patients (9.2%, 95% CI 7.4% to 11.2%) such that the post-test probabilities of both a positive (26.3%, 95% CI 19.8% to 33.7%) and a negative SeptiFast test (5.6%, 95% CI 4.1% to 7.4%) indicate the potential limitations of this technology in the diagnosis of bloodstream infection. However, latent class analysis indicates that BC has a low sensitivity, questioning its relevance as a reference test in this setting. Using this analysis approach, the sensitivity of the SeptiFast test was low but also appeared significantly better than BC. Blood samples identified as positive by either culture or SeptiFast real-time PCR were associated with a high probability (> 95%) of infection, indicating higher diagnostic rule-in utility than was apparent using conventional analyses of diagnostic accuracy. SeptiFast real-time PCR on blood samples may have rapid rule-in utility for the diagnosis of health-care-associated bloodstream infection but the lack of sensitivity is a significant limiting factor. Innovations aimed at improved diagnostic sensitivity of real-time PCR in this setting are urgently required. Future work recommendations include technology developments to improve the efficiency of pathogen DNA extraction and the capacity to detect a much broader range of pathogens and drug resistance genes and the application of new statistical approaches able to more reliably assess test performance in situation where the reference standard (e.g. blood culture in the setting of high antimicrobial use) is

  4. The Agile Rapid Global Combat Support (ARGCS) System: A Cost and Benefit Analysis of Including the ARGCS Technologies in the Acquisition of the Enhanced Consolidated Support System (ECASS) (United States)


    Franck and Carmelita Troy in January 2007. Revised in May of 2007, this interim BCA, based on the data then available, offered an assessment of Franck, Raymond and Carmelita Troy, Agile Rapid Global Combat Support, Business Case Analysis, Version 1.0. Naval

  5. Rapid prototyping in medical sciences

    Directory of Open Access Journals (Sweden)

    Ákos Márk Horváth


    Full Text Available Even if it sound a bit incredible rapid prototyping (RPT as production method has been used for decades in other professions. Nevertheless medical science just started discover the possibilities of this technology and use the offered benefits of 3D printing. In this paper authors have investigated the pharmaceutical usage of rapid prototyping.

  6. Rapid response manufacturing (RRM)

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)


    US industry is fighting to maintain its competitive edge in the global market place. Today markets fluctuate rapidly. Companies, to survive, have to be able to respond with quick-to-market, improved, high quality, cost efficient products. The way products are developed and brought to market can be improved and made more efficient through the proper incorporation of emerging technologies. The RRM project was established to leverage the expertise and resources of US private industries and federal agencies to develop, integrate, and deploy new technologies that meet critical needs for effective product realization. The RRM program addressed a needed change in the US Manufacturing infrastructure that will ensure US competitiveness in world market typified by mass customization. This project provided the effort needed to define, develop and establish a customizable infrastructure for rapid response product development design and manufacturing. A major project achievement was the development of a broad-based framework for automating and integrating the product and process design and manufacturing activities involved with machined parts. This was accomplished by coordinating and extending the application of feature-based product modeling, knowledge-based systems, integrated data management, and direct manufacturing technologies in a cooperative integrated computing environment. Key technological advancements include a product model that integrates product and process data in a consistent, minimally redundant manner, an advanced computer-aided engineering environment, knowledge-based software aids for design and process planning, and new production technologies to make products directly from design application software.

  7. The Application Trends of Rapid Prototyping Manufacturing

    Directory of Open Access Journals (Sweden)

    Qiu Xiao Lin


    characteristics of laser stero lithography (LSL selective laser sintering (SLS, three-dimensional printing (DP, fused deposition modeling (FDM, computer numerical control (CNC and other rapid prototyping technologies. After discussed these five rapid prototyping technology materials, we presented the hotspot and direction of rapid prototyping technology and look forward to the development of its technique, the expansion of its field and the progress of its academic ideology.

  8. Rapid Prototyping (United States)


    Javelin, a Lone Peak Engineering Inc. Company has introduced the SteamRoller(TM) System as a commercial product. The system was designed by Javelin during a Phase II NASA funded small commercial product. The purpose of the invention was to allow automated-feed of flexible ceramic tapes to the Laminated Object Manufacturing rapid prototyping equipment. The ceramic material that Javelin was working with during the Phase II project is silicon nitride. This engineered ceramic material is of interest for space-based component.

  9. Electric and Magnetic Fields (EMF) RAPID Program Engineering Project 8: FINAL REPORT, Evaluation of Field Reduction Technologies, Volume 1 (Report) and Volume 2 (Appendices)

    Energy Technology Data Exchange (ETDEWEB)

    Commonwealth Associates, Inc.; IIT Research Institute


    This draft report consists of two volumes. Volume 1, the main body, contains an introducto~ sectionj an overview of magnetic fields sectio~ and field reduction technology evaluation section. Magnetic field reduction methods are evalpated for transmission lines, distribution Iines,sulxtations, building wiring applkmd machinery, and transportation systems. The evaluation considers effectiveness, co% and other ftiors. Volume 2 contains five appendices, Append~ A presents magnetic field shielding information. Appendices B and C present design assumptions and magnetic field plots for transmission and distribution lines, respectively. Appendices D and E present cost estimate details for transmission and distribution limes, respectively.

  10. Rapid Screening and Identification of Daidzein Metabolites in Rats Based on UHPLC-LTQ-Orbitrap Mass Spectrometry Coupled with Data-Mining Technologies

    Directory of Open Access Journals (Sweden)

    Wenjing Zhao


    Full Text Available Daidzein, the main bioactive soy isoflavone in Nature, has been found to possess many biological functions. It has been investigated in particular as a phytoestrogen owing to the similarity of its structure with that of the human hormone estrogen. Due to the lack of comprehensive studies on daidzein metabolism, further research is still required to clarify its in vivo metabolic fate and intermediate processes. In this study, an efficient strategy was established using UHPLC-LTQ-Orbitrap mass spectrometry to profile the metabolism of daidzein in rats. Meanwhile, multiple data-mining methods including high-resolution extracted ion chromatogram (HREIC, multiple mass defect filtering (MMDF, neutral loss fragment (NLF, and diagnostic product ion (DPI were utilized to investigate daidzein metabolites from the HR-ESI-MS1 to ESI-MSn stage in both positive and negative ion modes. Consequently, 59 metabolites, including prototype compounds, were positively or tentatively elucidated based on reference standards, accurate mass measurements, mass fragmentation behaviors, chromatographic retention times, and corresponding calculated ClogP values. As a result, dehydration, hydrogenation, methylation, dimethylation, glucuronidation, glucosylation, sulfonation, ring-cleavage, and their composite reactions were ascertained to interpret its in vivo biotransformation. Overall, our results not only revealed the potential pharmacodynamics forms of daidzein, but also aid in establishing a practical strategy for rapid screening and identifying metabolites of natural compounds.

  11. Rapid Screening and Identification of Daidzein Metabolites in Rats Based on UHPLC-LTQ-Orbitrap Mass Spectrometry Coupled with Data-Mining Technologies. (United States)

    Zhao, Wenjing; Shang, Zhanpeng; Li, Qinqing; Huang, Moran; He, Wenbin; Wang, Zhibin; Zhang, Jiayu


    Daidzein, the main bioactive soy isoflavone in Nature, has been found to possess many biological functions. It has been investigated in particular as a phytoestrogen owing to the similarity of its structure with that of the human hormone estrogen. Due to the lack of comprehensive studies on daidzein metabolism, further research is still required to clarify its in vivo metabolic fate and intermediate processes. In this study, an efficient strategy was established using UHPLC-LTQ-Orbitrap mass spectrometry to profile the metabolism of daidzein in rats. Meanwhile, multiple data-mining methods including high-resolution extracted ion chromatogram (HREIC), multiple mass defect filtering (MMDF), neutral loss fragment (NLF), and diagnostic product ion (DPI) were utilized to investigate daidzein metabolites from the HR-ESI-MS¹ to ESI-MSn stage in both positive and negative ion modes. Consequently, 59 metabolites, including prototype compounds, were positively or tentatively elucidated based on reference standards, accurate mass measurements, mass fragmentation behaviors, chromatographic retention times, and corresponding calculated ClogP values. As a result, dehydration, hydrogenation, methylation, dimethylation, glucuronidation, glucosylation, sulfonation, ring-cleavage, and their composite reactions were ascertained to interpret its in vivo biotransformation. Overall, our results not only revealed the potential pharmacodynamics forms of daidzein, but also aid in establishing a practical strategy for rapid screening and identifying metabolites of natural compounds.

  12. Rapid Airplane Parametric Input Design (RAPID) (United States)

    Smith, Robert E.


    RAPID is a methodology and software system to define a class of airplane configurations and directly evaluate surface grids, volume grids, and grid sensitivity on and about the configurations. A distinguishing characteristic which separates RAPID from other airplane surface modellers is that the output grids and grid sensitivity are directly applicable in CFD analysis. A small set of design parameters and grid control parameters govern the process which is incorporated into interactive software for 'real time' visual analysis and into batch software for the application of optimization technology. The computed surface grids and volume grids are suitable for a wide range of Computational Fluid Dynamics (CFD) simulation. The general airplane configuration has wing, fuselage, horizontal tail, and vertical tail components. The double-delta wing and tail components are manifested by solving a fourth order partial differential equation (PDE) subject to Dirichlet and Neumann boundary conditions. The design parameters are incorporated into the boundary conditions and therefore govern the shapes of the surfaces. The PDE solution yields a smooth transition between boundaries. Surface grids suitable for CFD calculation are created by establishing an H-type topology about the configuration and incorporating grid spacing functions in the PDE equation for the lifting components and the fuselage definition equations. User specified grid parameters govern the location and degree of grid concentration. A two-block volume grid about a configuration is calculated using the Control Point Form (CPF) technique. The interactive software, which runs on Silicon Graphics IRIS workstations, allows design parameters to be continuously varied and the resulting surface grid to be observed in real time. The batch software computes both the surface and volume grids and also computes the sensitivity of the output grid with respect to the input design parameters by applying the precompiler tool

  13. Rapid transitions

    Energy Technology Data Exchange (ETDEWEB)

    Hamrin, J.G.


    Solar energy programs are entering a critical transitional period as we move from the initial marketing of solar technologies into a phase of widespread commercialization. We face the dual challenge of trying to get enough solar systems in place fast enough to prove solar is a viable alternative, while trying to ensure the systems are designed and installed properly, proving the energy savings as promised. This is a period of both great opportunity and high risk as the field becomes crowded with new solar cheerleaders and supporters but seldom enough competent players. The status of existing and proposed programs for the accelerated commercialization of solar energy in California is described.

  14. Final report on LDRD project: Low-cost Pd-catalyzed metallization technology for rapid prototyping of electronic substrates and devices

    Energy Technology Data Exchange (ETDEWEB)

    Chen, K.S.; Morgan, W.P.; Zich, J.L.


    A low-cost, thermally-activated, palladium-catalyzed metallization process was developed for rapid prototyping of polymeric electronic substrates and devices. The process was successfully applied in producing adhesiveless copper/polyimide laminates with high peel strengths and thick copper coating; copper/polyimide laminates are widely used in fabricating interconnects such as printed wiring boards (PWBs) and flexible circuits. Also successfully metallized using this low-cost metallization process were: (1) scaled-down models of radar-and-communication antenna and waveguide; (2) scaled-down model of pulsed-power-accelerator electrode; (3) three-dimensional micro-porous, open-cell vitreous carbon foams. Moreover, additive patterned metallization was successfully achieved by selectively printing or plotting the catalyst ink only on areas where metallization is desired, and by uniform thermal activation. Additive patterned metallization eliminates the time-consuming, costly and environmentally-unfriendly etching process that is routinely carried out in conventional subtractive patterned metallization. A metallization process via ultraviolet (UV) irradiation activation was also demonstrated. In this process palladium-catalyst solution is first uniformly coated onto the substrate. A masking pattern is used to cover the areas where metallization is not wanted. UV irradiation is applied uniformly to activate the palladium catalyst and to cure the polymer carrier in areas that are not covered by the mask. Metal is then deposited by electroless plating only or by a combination of electroless and electrolytic plating. This UV-activation technique is particularly useful in additive fine-line patterned metallization. Lastly, computer models for electrolytic and electroless plating processes were developed to provide guidance in plating-process design.

  15. The mass spectrometry technology MALDI-TOF (Matrix-Assisted Laser Desorption/Ionization Time- Of-Flight for a more rapid and economic workflow in the clinical microbiology laboratory

    Directory of Open Access Journals (Sweden)

    Simona Barnini


    Full Text Available Introduction: In order to improve the outcome of patients, reduce length of stay, costs and resources engaged in diagnostics, more rapid reports are requested to the clinical microbiologists.The purpose of this study is to assess the impact on workflow of MALDI-TOF technology, recently made available for use in routine diagnostics. Methods:The work list by the management information system is sent to the instrument MALDI-TOF, where are held at least three successive analytic sessions: the first includes bacteria isolated from CSF, blood cultures, and cases already reported as serious/urgent, the second includes all other germs isolated, the third, microorganisms that require extraction with trifluoroacetic acid (TFA or formic acid (FA for identification.The results of each session direct to the execution of different types of susceptibility testing. Results:The times of microbial identifications are reduced by 24 or 48 hours and made available to the clinician for the rational empirical therapy.The reagent costs are reduced by 40%.The subcultures were reduced by 80%, and microscopic examinations by 50%.The antibiotic susceptibility tests were immediately performed with the most appropriate method, based on the knowledge of local epidemiology and microbial species. Conclusion:The bacteriology is the less automated discipline among the clinical laboratory activities and results of diagnostic tests are poorly well-timed. The new interpretative algorithms of MALDI-TOF spectra, now available, allow the correct identification of bacteria in near real time, completely eliminating the wait is necessary for biochemical identification and guiding the operator in selecting the most appropriate antibiotic susceptibility tests. This technology makes work more rapid, economic and efficient, eliminating errors and, together with effective computerization of data, transforms the information content of the microbiological report, making it much more effective

  16. Návrh prototypového dílu s využitím technologií reverzního inženýrství a rapid prototyping


    Luňák, Václav


    Bakalářská práce je zaměřena na postup výroby součásti blinkru pro motocykl s využitím technologií reverzního inženýrství a Rapid Prototyping. Práce obsahuje stručný popis dostupných metod těchto technologií. V následujících částech se práce zabývá návrhem součásti a přípravou pro odlévání. Výroba součásti se provádí metodou FDM. Následně probíhá kontrola součásti 3D skenerem ATOS. Součást se porovná s původním návrhem součásti. Pro součást se vyrobí silikonová forma. Forma slouží pro odléván...

  17. Rapid Detection of Pathogens

    Energy Technology Data Exchange (ETDEWEB)

    David Perlin


    Pathogen identification is a crucial first defense against bioterrorism. A major emphasis of our national biodefense strategy is to establish fast, accurate and sensitive assays for diagnosis of infectious diseases agents. Such assays will ensure early and appropriate treatment of infected patients. Rapid diagnostics can also support infection control measures, which monitor and limit the spread of infectious diseases agents. Many select agents are highly transmissible in the early stages of disease, and it is critical to identify infected patients and limit the risk to the remainder of the population and to stem potential panic in the general population. Nucleic acid-based molecular approaches for identification overcome many of the deficiencies associated with conventional culture methods by exploiting both large- and small-scale genomic differences between organisms. PCR-based amplification of highly conserved ribosomal RNA (rRNA) genes, intergenic sequences, and specific toxin genes is currently the most reliable approach for bacterial, fungal and many viral pathogenic agents. When combined with fluorescence-based oligonucleotide detection systems, this approach provides real-time, quantitative, high fidelity analysis capable of single nucleotide allelic discrimination (4). These probe systems offer rapid turn around time (<2 h) and are suitable for high throughput, automated multiplex operations that are critical for clinical diagnostic laboratories. In this pilot program, we have used molecular beacon technology invented at the Public health Research Institute to develop a new generation of molecular probes to rapidly detect important agents of infectious diseases. We have also developed protocols to rapidly extract nucleic acids from a variety of clinical specimen including and blood and tissue to for detection in the molecular assays. This work represented a cooperative research development program between the Kramer-Tyagi/Perlin labs on probe development

  18. Rapid evolution of air sensor technologies (United States)

    Outdoor air pollution measurement approaches have historically been conducted using stationary shelters that require significant space, power, and expertise to operate. The cost and logistical requirements to conduct monitoring have limited the number of locations with continuou...

  19. Rapid Technology Assessment Framework for Land Logistics (United States)


    significant trends in this domain has been globalisation of the supply chains associated with reduction of local manufacturing. This has given us...broad and global in nature due to ICT connectivity and globalisation , with some being more extreme extrapolations of the current trends...40] • Financial austerity [4, 36, 38] • Globalisation of supply chains leading to reduced local manufacturing and better standardisation

  20. Rapid, Automated, and Specific Immunoassay to Directly Measure Matrix Metalloproteinase-9–Tissue Inhibitor of Metalloproteinase-1 Interactions in Human Plasma Using AlphaLISA Technology: A New Alternative to Classical ELISA (United States)

    Pulido-Olmo, Helena; Rodríguez-Sánchez, Elena; Navarro-García, José Alberto; Barderas, María G.; Álvarez-Llamas, Gloria; Segura, Julián; Fernández-Alfonso, Marisol; Ruilope, Luis M.; Ruiz-Hurtado, Gema


    The protocol describes a novel, rapid, and no-wash one-step immunoassay for highly sensitive and direct detection of the complexes between matrix metalloproteinases (MMPs) and their tissue inhibitor of metalloproteinases (TIMPs) based on AlphaLISA® technology. We describe two procedures: (i) one approach is used to analyze MMP-9–TIMP-1 interactions using recombinant human MMP-9 with its corresponding recombinant human TIMP-1 inhibitor and (ii) the second approach is used to analyze native or endogenous MMP-9–TIMP-1 protein interactions in samples of human plasma. Evaluating native MMP-9–TIMP-1 complexes using this approach avoids the use of indirect calculations of the MMP-9/TIMP-1 ratio for which independent MMP-9 and TIMP-1 quantifications by two conventional ELISAs are needed. The MMP-9–TIMP-1 AlphaLISA® assay is quick, highly simplified, and cost-effective and can be completed in less than 3 h. Moreover, the assay has great potential for use in basic and preclinical research as it allows direct determination of native MMP-9–TIMP-1 complexes in circulating blood as biofluid. PMID:28791014

  1. Rapid, Automated, and Specific Immunoassay to Directly Measure Matrix Metalloproteinase-9–Tissue Inhibitor of Metalloproteinase-1 Interactions in Human Plasma Using AlphaLISA Technology: A New Alternative to Classical ELISA

    Directory of Open Access Journals (Sweden)

    Helena Pulido-Olmo


    Full Text Available The protocol describes a novel, rapid, and no-wash one-step immunoassay for highly sensitive and direct detection of the complexes between matrix metalloproteinases (MMPs and their tissue inhibitor of metalloproteinases (TIMPs based on AlphaLISA® technology. We describe two procedures: (i one approach is used to analyze MMP-9–TIMP-1 interactions using recombinant human MMP-9 with its corresponding recombinant human TIMP-1 inhibitor and (ii the second approach is used to analyze native or endogenous MMP-9–TIMP-1 protein interactions in samples of human plasma. Evaluating native MMP-9–TIMP-1 complexes using this approach avoids the use of indirect calculations of the MMP-9/TIMP-1 ratio for which independent MMP-9 and TIMP-1 quantifications by two conventional ELISAs are needed. The MMP-9–TIMP-1 AlphaLISA® assay is quick, highly simplified, and cost-effective and can be completed in less than 3 h. Moreover, the assay has great potential for use in basic and preclinical research as it allows direct determination of native MMP-9–TIMP-1 complexes in circulating blood as biofluid.

  2. Rapid Chemical Exposure and Dose Research (United States)

    EPA evaluates the potential risks of the manufacture and use of thousands of chemicals. To assist with this evaluation, EPA scientists developed a rapid, automated model using off the shelf technology that predicts exposures for thousands of chemicals.

  3. Development and evaluation of an up-converting phosphor technology-based lateral flow assay for the rapid, simultaneous detection of Vibrio cholerae serogroups O1 and O139. (United States)

    Hao, Min; Zhang, Pingping; Li, Baisheng; Liu, Xiao; Zhao, Yong; Tan, Hailing; Sun, Chongyun; Wang, Xiaochen; Wang, Xinrui; Qiu, Haiyan; Wang, Duochun; Diao, Baowei; Jing, Huaiqi; Yang, Ruifu; Kan, Biao; Zhou, Lei


    Vibrio cholerae serogroups O1 and O139 are etiological agents of cholera, a serious and acute diarrheal disease, and rapid detection of V. cholerae is a key method for preventing and controlling cholera epidemics. Here, a point of care testing (POCT) method called Vch-UPT-LF, which is an up-converting phosphor technology-based lateral flow (UPT-LF) assay with a dual-target detection mode, was developed to detect V. cholerae O1 and O139 simultaneously from one sample loading. Although applying an independent reaction pair made both detection results for the two Vch-UPT-LF detection channels more stable, the sensitivity slightly declined from 104 to 105 colony-forming units (CFU) mL-1 compared with that of the single-target assay, while the quantification ranges covering four orders of magnitude were maintained. The strip showed excellent specificity for seven Vibrio species that are highly related genetically, and nine food-borne species whose transmission routes are similar to those of V. cholerae. The legitimate arrangement of the two adjacent test lines lessened the mutual impact of the quantitation results between the two targets, and the quantification values did not differ by more than one order of magnitude when the samples contained high concentrations of both V. cholerae O1 and O139. Under pre-incubation conditions, 1×101 CFU mL-1 of V. cholerae O1 or O139 could be detected in fewer than 7 h, while the Vch-UPT-LF assay exhibited sensitivity as high as a real-time fluorescent polymerase chain reaction with fewer false-positive results. Therefore, successful development of Vch-UPT-LF as a dual-target assay for quantitative detection makes this assay a good candidate POCT method for the detection and surveillance of epidemic cholera.

  4. Globalization and Technology


    Traian-Alexandru Miu


    Globalization, very complex phenomenon, involves overcoming the barriers between different states, which allowed the rapid transfer of capital, technology, information, and the "toxins" from one country to another. First, the technology formed the basis of rapid expansion of great ideas promoted by globalization. Undeniable progress in the field of technology and science, has conferred to the man extraordinary powers that have been used most often to the detriment of his spiritual progress. W...

  5. Editorial: Advanced learning technologies


    Yu-Ju Lan; Gang-Shan Fu; Yang, Stephen J. H.; Jeff J.S. Huang


    Recent rapid development of advanced information technology brings high expectations of its potential to improvement and innovations in learning. This special issue is devoted to using some of the emerging technologies issues related to the topic of education and knowledge sharing, involving several cutting edge research outcomes from recent advancement of learning technologies. Advanced learning technologies are the composition of various related technologies and concepts such as mobile tech...

  6. 3D Printing for the Rapid Prototyping of Structural Electronics

    National Research Council Canada - National Science Library

    Macdonald, Eric; Salas, Rudy; Espalin, David; Perez, Mireya; Aguilera, Efrain; Muse, Dan; Wicker, Ryan B


    .... The use of advanced 3D printing technology enhanced with component placement and electrical interconnect deposition can provide electronic prototypes that now can be rapidly fabricated in comparable...

  7. Integrating Rapid Prototyping into Graphic Communications (United States)

    Xu, Renmei; Flowers, Jim


    Integrating different science, technology, engineering, and mathematics (STEM) areas can help students learn and leverage both the equipment and expertise at a single school. In comparing graphic communications classes with classes that involve rapid prototyping (RP) technologies like 3D printing, there are sufficient similarities between goals,…



    Amita Verma


    Tablet that disintegrate rapidly in the mouth are convenient for patient who have difficulty in swallowing conventional dosages forms. Although various formulation technologies like Zydis Technology, Durasolve Technology, Orasolve Technology, Flash Dose Technology, Wow Tab Technology, Flash Tab Technology, Quicksolv Technology, Lyos Technology, Fast Melt Technology and Zip-lets Technology are used. This review highlights numerous techniques to explain the phenomenon of preparing mouth disinte...

  9. The Notion of Technological Unemployment. (United States)

    Standing, Guy


    Rapid technological change is widely regarded as a primary cause of unemployment, especially in depressions. This article summarizes the diverse interpretations given to the notion of technological unemployment, critically examining the assumptions underlying those views. (Author/SSH)

  10. Editorial: Advanced learning technologies

    Directory of Open Access Journals (Sweden)

    Yu-Ju Lan


    Full Text Available Recent rapid development of advanced information technology brings high expectations of its potential to improvement and innovations in learning. This special issue is devoted to using some of the emerging technologies issues related to the topic of education and knowledge sharing, involving several cutting edge research outcomes from recent advancement of learning technologies. Advanced learning technologies are the composition of various related technologies and concepts such as mobile technologies and social media towards learner centered learning. This editorial note provides an overview of relevant issues discussed in this special issue.

  11. Rapid Prototyping Laboratory (United States)

    Federal Laboratory Consortium — The ARDEC Rapid Prototyping (RP) Laboratory was established in December 1992 to provide low cost RP capabilities to the ARDEC engineering community. The Stratasys,...

  12. To Internationalize Rapidly from Inception: Crowdsource

    Directory of Open Access Journals (Sweden)

    Nirosh Kannangara


    Full Text Available Technology entrepreneurs continuously search for tools to accelerate the internationalization of their startups. For the purpose of internationalizing rapidly from inception, we propose that technology startups use crowdsourcing to internalize the tacit knowledge embodied in members of a crowd distributed across various geographies. For example, a technology startup can outsource to a large crowd the definition of a customer problem that occurs across various geographies, the development of the best solution to the problem, and the identification of attractive business expansion opportunities. In this article, we analyze how three small firms use crowdsourcing, discuss the benefits of crowdsourcing, and offer six recommendations to technology entrepreneurs interested in using crowdsourcing to rapidly internationalize their startups from inception.

  13. Organizational Design for USSOCOM Rapid Acquisition (United States)


    2 Ibid., 249. 25 of the programs.3 In rapid innovation , it is important for Program Executive Officers to ensure that technical...organizational learning is what the company does in order to create innovative products and survive. They note that, “interviewees emphasized the importance ...14. ABSTRACT USSOCOM Special Operations Forces (SOF) Acquisition, Technology and Logistics (AT&L) struggles to keep pace with technology innovation

  14. Removable partial dentures: use of rapid prototyping. (United States)

    Lima, Julia Magalhaes Costa; Anami, Lilian Costa; Araujo, Rodrigo Maximo; Pavanelli, Carlos A


    The CAD/CAM technology associated with rapid prototyping (RP) is already widely used in the fabrication of all-ceramic fixed prostheses and in the biomedical area; however, the use of this technology for the manufacture of metal frames for removable dentures is new. This work reports the results of a literature review conducted on the use of CAD/CAM and RP in the manufacture of removable partial dentures. © 2014 by the American College of Prosthodontists.

  15. Rapid Active Sampling Package (United States)

    Peters, Gregory


    A field-deployable, battery-powered Rapid Active Sampling Package (RASP), originally designed for sampling strong materials during lunar and planetary missions, shows strong utility for terrestrial geological use. The technology is proving to be simple and effective for sampling and processing materials of strength. Although this originally was intended for planetary and lunar applications, the RASP is very useful as a powered hand tool for geologists and the mining industry to quickly sample and process rocks in the field on Earth. The RASP allows geologists to surgically acquire samples of rock for later laboratory analysis. This tool, roughly the size of a wrench, allows the user to cut away swaths of weathering rinds, revealing pristine rock surfaces for observation and subsequent sampling with the same tool. RASPing deeper (.3.5 cm) exposes single rock strata in-situ. Where a geologist fs hammer can only expose unweathered layers of rock, the RASP can do the same, and then has the added ability to capture and process samples into powder with particle sizes less than 150 microns, making it easier for XRD/XRF (x-ray diffraction/x-ray fluorescence). The tool uses a rotating rasp bit (or two counter-rotating bits) that resides inside or above the catch container. The container has an open slot to allow the bit to extend outside the container and to allow cuttings to enter and be caught. When the slot and rasp bit are in contact with a substrate, the bit is plunged into it in a matter of seconds to reach pristine rock. A user in the field may sample a rock multiple times at multiple depths in minutes, instead of having to cut out huge, heavy rock samples for transport back to a lab for analysis. Because of the speed and accuracy of the RASP, hundreds of samples can be taken in one day. RASP-acquired samples are small and easily carried. A user can characterize more area in less time than by using conventional methods. The field-deployable RASP used a Ni

  16. Applied Semantic Web Technologies

    CERN Document Server

    Sugumaran, Vijayan


    The rapid advancement of semantic web technologies, along with the fact that they are at various levels of maturity, has left many practitioners confused about the current state of these technologies. Focusing on the most mature technologies, Applied Semantic Web Technologies integrates theory with case studies to illustrate the history, current state, and future direction of the semantic web. It maintains an emphasis on real-world applications and examines the technical and practical issues related to the use of semantic technologies in intelligent information management. The book starts with

  17. Rapid shallow breathing (United States)

    ... the smallest air passages of the lungs in children ( bronchiolitis ) Pneumonia or other lung infection Transient tachypnea of the newborn Anxiety and panic Other serious lung disease Home Care Rapid, shallow breathing should not be treated at home. It is ...

  18. Rapid Strep Test (United States)

    ... worse than normal. Your first thoughts turn to strep throat. A rapid strep test in your doctor’s office ... your suspicions.Viruses cause most sore throats. However, strep throat is an infection caused by the Group A ...

  19. Rapid Column Extraction method for SoilRapid Column Extraction method for Soil

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, Sherrod, L. III; Culligan, Brian K.


    The analysis of actinides in environmental soil and sediment samples is very important for environmental monitoring as well as for emergency preparedness. A new, rapid actinide separation method has been developed and implemented that provides total dissolution of large soil samples, high chemical recoveries and effective removal of matrix interferences. This method uses stacked TEVA Resin{reg_sign}, TRU Resin{reg_sign} and DGA-Resin{reg_sign} cartridges from Eichrom Technologies (Darien, IL, USA) that allows the rapid separation of plutonium (Pu) neptunium (Np), uranium (U), americium (Am), and curium (Cm) using a single multi-stage column combined with alpha spectrometry. The method combines a rapid fusion step for total dissolution to dissolve refractory analytes and matrix removal using cerium fluoride precipitation to remove the difficult soil matrix. By using vacuum box cartridge technology with rapid flow rates, sample preparation time is minimized.

  20. Battling malaria in rural Zambia with modern technology: a qualitative study on the value of cell phones, geographical information systems, asymptomatic carriers and rapid diagnostic tests to identify, treat and control malaria

    Directory of Open Access Journals (Sweden)

    David Nygren


    Full Text Available During the last decade much progress has been made in reducing malaria transmission in Macha, Southern Province, Zambia. Introduction of artemisinin combination therapies as well as mass screenings of asymptomatic carriers is believed to have contributed the most. When an endemic malaria situation is moving towards a non-endemic situation the resident population loses acquired immunity and therefore active case detection and efficient surveillance is crucial to prevent epidemic outbreaks. Our purpose was to evaluate the impact of cell phone surveillance and geographical information systems on malaria control in Macha. Furthermore, it evaluates what screening and treatment of asymptomatic carriers and implementation of rapid diagnostic tests in rural health care has led to. Ten in-depth semistructured interviews, field observations and data collection were performed at the Macha Research Trust and at surrounding rural health centers. This qualitative method was inspired by rapid assessment procedure. The cell phone surveillance has been easily integrated in health care, and its integration with Geographical Information Systems has provided the ability to follow malaria transmission on a weekly basis. In addition, active case detection of asymptomatic carriers has been fruitful, which is reflected in it soon being applied nationwide. Furthermore, rapid diagnostic tests have provided rural health centers with reliable malaria diagnostics, thereby decreasing excessive malaria treatments and selection for drug resistance. This report reflects the importance of asymptomatic carriers in targeting malaria elimination, as well as development of effective surveillance systems when transmission decreases. Such an approach would be cost-efficient in the long run through positive effects in reduced child mortality and relief in health care.

  1. RAPID3? Aptly named! (United States)

    Berthelot, J-M


    The RAPID3 score is the sum of three 0-10 patient self-report scores: pain, functional impairment on MDHAQ, and patient global estimate. It requires 5 seconds for scoring and can be used in all rheumatologic conditions, although it has mostly been used in rheumatoid arthritis where cutoffs for low disease activity (12/30) have been set. A RAPID3 score of ≤ 3/30 with 1 or 0 swollen joints (RAPID3 ≤ 3 + ≤ SJ1) provides remission criteria comparable to Boolean, SDAI, CDAI, and DAS28 remission criteria, in far less time than a formal joint count. RAPID3 performs as well as the DAS28 in separating active drugs from placebos in clinical trials. RAPID3 also predicts subsequent structural disease progression. RAPID3 can be determined at short intervals at home, allowing the determination of the area under the curve of disease activity between two visits and flare detection. However, RAPID3 should not be seen as a substitute for DAS28 and face to face visits in routine care. Monitoring patient status with only self-report information without a rheumatologist's advice (including joints and physical examination, and consideration of imaging and laboratory tests) may indeed be as undesirable for most patients than joint examination without a patient questionnaire. Conversely, combining the RAPID3 and the DAS28 may consist in faster or more sensitive confirmation that a medication is effective. Similarly, better enquiring of most important concerns of patients (pain, functional status and overall opinion on their disorder) should reinforces patients' confidence in their rheumatologist and treatments.

  2. Implementation of rapid diagnostics with antimicrobial stewardship. (United States)

    Minejima, Emi; Wong-Beringer, Annie


    Antimicrobial stewardship (ASP) is an intervention-based program to improve patient outcomes to infection while limiting spread of resistance and unintended consequences. Many rapid diagnostic tools are now FDA cleared for clinical use, with three evaluated across multiple settings: Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry, Verigene, and FilmArray. Areas covered: This review will focus on studies published that evaluated ASP intervention with rapid diagnostic implementation on outcomes of infection. A description of the key ASP personnel, rapid diagnostic notification methods, hours of notification, and scope of ASP intervention is summarized. Expert commentary: It is critical that ASPs continually re-evaluate and evolve with technological advances. Rapid diagnostic tools are powerful in their ability to identify organisms quickly. A trained clinician is needed to evaluate the results and interact with the providers to educate them on result interpretation and optimal antimicrobial selection to maximize treatment success.

  3. An Analysis of Technology Transition Within the Department of Defense (United States)


    for Savings Program TPM Technical Performance Measure TRA Technology Readiness Assessment TRL Technology Readiness Level TTI Technology...Rapid Technology Transition Program (RTT) Navy Has a charter to rapidly transition technology from any source, including those not traditionally...Metrics such as MOEs, Technical Performance Measures ( TPMs ), and Design-dependent Parameters (DDPs) should be established and monitored to ensure

  4. Robotic craft: Rapid-prototype technology may take the labor out of craft, but it also allows individually styled items to compete with those that have been mass-produced


    Miodownik, M.


    Computer-controlled manufacturing machines are no longer confined in the large companies, but they are also being increasingly bought and used in small small businesses and craftspeople. Customers can order any design that they in the shop, which is then tailored digitally to their exact needs. Another important aspect of this machines is that they are affordable, so that jewelers, designers, and craft cooperatives can compete on price and precision with big business. The technology is revolu...

  5. Globalization and Technology

    Directory of Open Access Journals (Sweden)

    Traian-Alexandru Miu


    Full Text Available Globalization, very complex phenomenon, involves overcoming the barriers between different states, which allowed the rapid transfer of capital, technology, information, and the "toxins" from one country to another. First, the technology formed the basis of rapid expansion of great ideas promoted by globalization. Undeniable progress in the field of technology and science, has conferred to the man extraordinary powers that have been used most often to the detriment of his spiritual progress. We must not deny that science and technology have brought many benefits to human, and he could expand the knowledge horizon upon the world in which he lives, exploiting information acquired and share them with others. Science and technology must become for postmodern man ways of talk and communion between human and divinity, all to the praise of God and the perfection of the creature.

  6. Technology Integration Experiences of Teachers (United States)

    Çoklar, Ahmet Naci; Yurdakul, Isil Kabakçi


    Teachers are important providers of educational sustainability. Teachers' ability to adapt themselves to rapidly developing technologies applicable to learning environments is connected with technology integration. The purpose of this study is to investigate teachers' technology integration experiences in the course of learning and teaching…


    Indian Academy of Sciences (India)

    Sulfated polyborate: A mild, efficient catalyst for synthesis of N-tert- butyl/N-trityl protected amides via Ritter reaction. KRISHNA S INDALKAR, CHETAN K KHATRI and GANESH U CHATURBHUJ*. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, Maharashtra 400 019 ...

  8. Rapid Adaptation in Digital Transformation

    DEFF Research Database (Denmark)

    Hansen, Anne Mette; Kræmmergaard, Pernille; Mathiassen, Lars


    the organization’s digitization approach. We demonstrate in detail how the leaders within these two organizations were engaged and offer recommendations for how other organizations can use the PPM to rapidly adapt their approaches to digital transformation through more effective IS leadership roles.......In today’s highly dynamic environments, organizational leaders need to quickly adapt existing approaches to digital transformation. However, without a shared mindset between IS and business leaders, it is difficult to adopt new approaches in response to changes in the competitive and technology...... landscape. In this article, we share insights gained from two public sector organizations in which IS and business leaders used the Participatory Process Model (PPM) designed by the authors to share their assumptions about IS leadership, challenge existing IT strategies and collaboration patterns and adapt...

  9. Moved by a Rapid Transit (United States)

    Bueter, C.


    Enticing by virtue of its predictability, historical utility, and spectacle, the transit of Venus is a niche event among astronomical phenomena. Though the value of a transit for scientific purposes is now diminished, the brief appearance of Venus silhouetted against the background of the Sun in 2004 moved the artistic community to celebrate the rare alignment. Artists of all ages combined old traditions with fresh technology to create a 21st-century tapestry of music, sculpture, paintings, glasswork, quilts, sky shows, and digital imagery. A full catalog of transit-related art generated over the centuries would feature the sampling of entries presented here and at the Moved by a Rapid Transit website.

  10. Rapid Tooling via Investment Casting and Rapid Prototype Patterns

    Energy Technology Data Exchange (ETDEWEB)

    Baldwin, Michael D.


    The objective of this work to develop the materials processing and design technologies required to reduce the die development time for metal mold processes from 12 months to 3 months, using die casting of Al and Mg as the example process. Sandia demonstrated that investment casting, using rapid prototype patterns produced from Stereo lithography or Selective laser Sintering, was a viable alternative/supplement to the current technology of machining form wrought stock. A demonstration die insert (ejector halt) was investment cast and subsequently tested in the die casting environment. The stationary half of the die insert was machined from wrought material to benchmark the cast half. The two inserts were run in a die casting machine for 3,100 shots of aluminum and at the end of the run no visible difference could be detected between the cast and machined inserts. Inspection concluded that the cast insert performed identically to the machined insert. Both inserts had no indications of heat checking or degradation.

  11. Rapid small lot manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Harrigan, R.W.


    The direct connection of information, captured in forms such as CAD databases, to the factory floor is enabling a revolution in manufacturing. Rapid response to very dynamic market conditions is becoming the norm rather than the exception. In order to provide economical rapid fabrication of small numbers of variable products, one must design with manufacturing constraints in mind. In addition, flexible manufacturing systems must be programmed automatically to reduce the time for product change over in the factory and eliminate human errors. Sensor based machine control is needed to adapt idealized, model based machine programs to uncontrolled variables such as the condition of raw materials and fabrication tolerances.

  12. Rapid Cycling and Its Treatment (United States)

    ... Announcements Public Service Announcements Partnering with DBSA Rapid Cycling and its Treatment What is bipolar disorder? Bipolar ... to Depression and Manic Depression . What is rapid cycling? Rapid cycling is defined as four or more ...

  13. Rapid die manufacturing using direct laser metal deposition

    CSIR Research Space (South Africa)

    Pereira, MFVT


    Full Text Available This paper highlights the work undertaken at the CSIR on the issue of rapid die manufacturing through the application and evaluation of a rapid prototyping technique and coating technologies applied to die components of a high pressure casting die...

  14. Rapid manufacturing for microfluidics

    CSIR Research Space (South Africa)

    Land, K


    Full Text Available . Microfluidics is at the forefront of developing solutions for drug discovery, diagnostics (from glucose tests to malaria and TB testing) and environmental diagnostics (E-coli monitoring of drinking water). In order to quickly implement new designs, a rapid...

  15. Rapid Prototyping in PVS (United States)

    Munoz, Cesar A.; Butler, Ricky (Technical Monitor)


    PVSio is a conservative extension to the PVS prelude library that provides basic input/output capabilities to the PVS ground evaluator. It supports rapid prototyping in PVS by enhancing the specification language with built-in constructs for string manipulation, floating point arithmetic, and input/output operations.

  16. Rapid prototyping-assisted maxillofacial reconstruction. (United States)

    Peng, Qian; Tang, Zhangui; Liu, Ousheng; Peng, Zhiwei


    Rapid prototyping (RP) technologies have found many uses in dentistry, and especially oral and maxillofacial surgery, due to its ability to promote product development while at the same time reducing cost and depositing a part of any degree of complexity theoretically. This paper provides an overview of RP technologies for maxillofacial reconstruction covering both fundamentals and applications of the technologies. Key fundamentals of RP technologies involving the history, characteristics, and principles are reviewed. A number of RP applications to the main fields of oral and maxillofacial surgery, including restoration of maxillofacial deformities and defects, reduction of functional bone tissues, correction of dento-maxillofacial deformities, and fabrication of maxillofacial prostheses, are discussed. The most remarkable challenges for development of RP-assisted maxillofacial surgery and promising solutions are also elaborated.

  17. Rapid response manufacturing (RRM). Final CRADA report

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)


    US industry is fighting to maintain its competitive edge in the global market place. Markets fluctuate rapidly. Companies have to be able to respond quickly with improved, high quality, cost efficient products. Because companies and their suppliers are geographically distributed, rapid product realization is dependent on the development of a secure integrated concurrent engineering environment operating across multiple business entities. The way products are developed and brought to market can be improved and made more efficient through the proper incorporation of emerging technologies implemented in a secure environment. This documents the work done under this CRADA to develop capabilities, which permit the effective application, incorporation, and use of advanced technologies in a secure environment to facilitate the product realization process. Lockheed Martin Energy Systems (LMES), through a CRADA with the National Center for Manufacturing Sciences (NCMS), worked within a consortium of major industrial firms--Ford, General Motors, Texas Instruments, United Technologies, and Eastman Kodak--and several small suppliers of advanced manufacturing technology--MacNeal-Schwendler Corp., Teknowledge Corp., Cimplex Corp., Concentra, Spatial Technology, and Structural Dynamics Research Corp. (SDRC)--to create infrastructure to support the development and implementation of secure engineering environments for Rapid Response Manufacturing. The major accomplishment achieved under this CRADA was the demonstration of a prototypical implementation of a broad-based generic framework for automating and integrating the design-to-manufacturing activities associated with machined parts in a secure NWC compliant environment. Specifically, methods needed to permit the effective application, incorporation, and use of advanced technologies in a secure environment to facilitate the product realization process were developed and demonstrated. An important aspect of this demonstration was

  18. Advanced manufacturing: Technology diffusion

    Energy Technology Data Exchange (ETDEWEB)

    Tesar, A.


    In this paper we examine how manufacturing technology diffuses rom the developers of technology across national borders to those who do not have the capability or resources to develop advanced technology on their own. None of the wide variety of technology diffusion mechanisms discussed in this paper are new, yet the opportunities to apply these mechanisms are growing. A dramatic increase in technology diffusion occurred over the last decade. The two major trends which probably drive this increase are a worldwide inclination towards ``freer`` markets and diminishing isolation. Technology is most rapidly diffusing from the US In fact, the US is supplying technology for the rest of the world. The value of the technology supplied by the US more than doubled from 1985 to 1992 (see the Introduction for details). History shows us that technology diffusion is inevitable. It is the rates at which technologies diffuse to other countries which can vary considerably. Manufacturers in these countries are increasingly able to absorb technology. Their manufacturing efficiency is expected to progress as technology becomes increasingly available and utilized.

  19. Use of Optical Imaging Technology in the Validation of a New, Rapid, Cost-Effective Drug Screen as Part of a Tiered In Vivo Screening Paradigm for Development of Drugs To Treat Cutaneous Leishmaniasis. (United States)

    Caridha, Diana; Parriot, Sandi; Hudson, Thomas H; Lang, Thierry; Ngundam, Franklyn; Leed, Susan; Sena, Jenell; Harris, Michael; O'Neil, Michael; Sciotti, Richard; Read, Lisa; Lecoeur, Herve; Hickman, Mark; Grogl, Max


    In any drug discovery and development effort, a reduction in the time of the lead optimization cycle is critical to decrease the time to license and reduce costs. In addition, ethical guidelines call for the more ethical use of animals to minimize the number of animals used and decrease their suffering. Therefore, any effort to develop drugs to treat cutaneous leishmaniasis requires multiple tiers of in vivo testing that start with higher-throughput efficacy assessments and progress to lower-throughput models with the most clinical relevance. Here, we describe the validation of a high-throughput, first-tier, noninvasive model of lesion suppression that uses an in vivo optical imaging technology for the initial screening of compounds. A strong correlation between luciferase activity and the parasite load at up to 18 days postinfection was found. This correlation allows the direct assessment of the effects of drug treatment on parasite burden. We demonstrate that there is a strong correlation between drug efficacy measured on day 18 postinfection and the suppression of lesion size by day 60 postinfection, which allows us to reach an accurate conclusion on drug efficacy in only 18 days. Compounds demonstrating a significant reduction in the bioluminescence signal compared to that in control animals can be tested in lower-throughput, more definitive tests of lesion cure in BALB/c mice and Golden Syrian hamsters (GSH) using Old World and New World parasites. Copyright © 2017 Caridha et al.

  20. Rapid manufacturing facilitated customisation


    Tuck, Christopher John; Hague, Richard; Ruffo, Massimiliano; Ransley, Michelle; Adams, Paul Russell


    Abstract This paper describes the production of body-fitting customised seat profiles utilising the following digital methods: three dimensional laser scanning, reverse engineering and Rapid Manufacturing (RM). The seat profiles have been manufactured in order to influence the comfort characteristics of an existing ejector seat manufactured by Martin Baker Aircraft Ltd. The seat, known as Navy Aircrew Common Ejection Seat (NACES), was originally designed with a generic profile. ...

  1. Tiber Personal Rapid Transit

    Directory of Open Access Journals (Sweden)

    Diego Carlo D'agostino


    Full Text Available The project “Tiber Personal Rapid Transit” have been presented by the author at the Rome City Vision Competition1 2010, an ideas competition, which challenges architects, engineers, designers, students and creatives individuals to develop visionary urban proposals with the intention of stimulating and supporting the contemporary city, in this case Rome. The Tiber PRT proposal tries to answer the competition questions with the definition of a provocative idea: a Personal Rapid transit System on the Tiber river banks. The project is located in the central section of the Tiber river and aims at the renewal of the river banks with the insertion of a Personal Rapid Transit infrastructure. The project area include the riverbank of Tiber from Rome Transtevere RFI station to Piazza del Popolo, an area where main touristic and leisure attractions are located. The intervention area is actually no used by the city users and residents and constitute itself a strong barrier in the heart of the historic city.


    National Research Council Canada - National Science Library

    Karolina S Prokopovic; Tijana B Prokopovic; Miloje A Jelic


      The rapid development of the Internet and the use of new possibilities which the digital technologies have brought about, have made significant changes in all the areas of business, including logistics...

  3. Increase in healthcare facilities and rapid environmental degradation

    African Journals Online (AJOL)


    Increase in healthcare facilities and rapid environmental degradation: A technological paradox in. Nigeria's urban centres. Akinwale Coker1* and Mynepalli K. C. Sridhar2. 1Department of Civil Engineering, Faculty of Technology, University of Ibadan, Oyo State, Nigeria. 2Division of Environmental Health, Department of ...

  4. Educational technologies in health sciences libraries: teaching technology skills. (United States)

    Hurst, Emily J


    As technology rapidly changes, libraries remain go-to points for education and technology skill development. In academic health sciences libraries, trends suggest librarians provide more training on technology topics than ever before. While education and training have always been roles for librarians, providing technology training on new mobile devices and emerging systems requires class creation and training capabilities that are new to many librarians. To appeal to their users, many health sciences librarians are interested in developing technology-based classes. This column explores the question: what skills are necessary for developing and teaching technology in an academic health sciences library setting?

  5. Educational Technologies in Health Science Libraries: Teaching Technology Skills (United States)

    Hurst, Emily J.


    As technology rapidly changes, libraries remain go-to points for education and technology skill development. In academic health sciences libraries, trends suggest librarians provide more training on technology topics than ever before. While education and training have always been roles for librarians, providing technology training on new mobile devices and emerging systems requires class creation and training capabilities that are new to many. To appeal to their users, many health sciences librarians are interested in developing technology-based classes. This column explores the question: what skills are necessary for developing and teaching technology in an academic health sciences library setting? PMID:24528269

  6. Energy-Saving Melting and Revert Reduction Technology (E-SMARRT): Use of Laser Engineered Net Shaping for Rapid Manufacturing of Dies with Protective Coatings and Improved Thermal Management

    Energy Technology Data Exchange (ETDEWEB)

    Brevick, Jerald R. [Ohio State University


    In the high pressure die casting process, molten metal is introduced into a die cavity at high pressure and velocity, enabling castings of thin wall section and complex geometry to be obtained. Traditional die materials have been hot work die steels, commonly H13. Manufacture of the dies involves machining the desired geometry from monolithic blocks of annealed tool steel, heat treating to desired hardness and toughness, and final machining, grinding and polishing. The die is fabricated with internal water cooling passages created by drilling. These materials and fabrication methods have been used for many years, however, there are limitations. Tool steels have relatively low thermal conductivity, and as a result, it takes time to remove the heat from the tool steel via the drilled internal water cooling passages. Furthermore, the low thermal conductivity generates large thermal gradients at the die cavity surfaces, which ultimately leads to thermal fatigue cracking on the surfaces of the die steel. The high die surface temperatures also promote the metallurgical bonding of the aluminum casting alloy to the surface of the die steel (soldering). In terms of process efficiency, these tooling limitations reduce the number of die castings that can be made per unit time by increasing cycle time required for cooling, and increasing downtime and cost to replace tooling which has failed either by soldering or by thermal fatigue cracking (heat checking). The objective of this research was to evaluate the feasibility of designing, fabricating, and testing high pressure die casting tooling having properties equivalent to H13 on the surface in contact with molten casting alloy - for high temperature and high velocity molten metal erosion resistance – but with the ability to conduct heat rapidly to interior water cooling passages. A layered bimetallic tool design was selected, and the design evaluated for thermal and mechanical performance via finite element analysis. H13 was

  7. Soft technologies, hard choices. (United States)

    Norman, C


    In the years since the 1st United Nations conference on science, technology, and development in 1963, technology has come under scrutiny and criticism. The 2nd such UN Conference was held in August 1979 and initiated a reassessment of technological development in all countries. The following problems are not amenable to Western-style technology: 1) unemployment; 2) disparities of wealth both inter- and intracountry; and 3) energy needs. Simple transference of technology from the rich to the poor countries will not create badly needed jobs. That is not to say that much capital-intensive technology, e.g., that used in producing chemical fertilizers, is not useful to developing countries. There is a need to spread capital resources and the benefits therefrom more broadly. For example, in the health field, efforts should be made to meet basic health needs rather than invest in expensive medical technology and high-cost hospitals. All the assumptions of rapid economic development for the less developed countries were made in the era of inexpensive energy sources. There is now a need to develop and use technologies utilizing renewable energy sources. Modern technology seems to be placing a stress on the world's biological systems. Certain technologies may simply be incompatible with the need to sustain the earth and its resources. Government efforts will be needed to supplement market action. A world of diversified technologies is envisioned.

  8. Planning for Instructional Technology in the Classroom (United States)

    Garza Mitchell, Regina L.


    Community colleges are known for keeping abreast of the latest instructional technologies, but the constant and rapid growth of available technology also presents challenges. This chapter reviews the current literature regarding instructional technology usage, with a focus on beneficial applications of technology for teaching and learning, and…

  9. Can information technology improve my ambulatory practice ...

    African Journals Online (AJOL)

    eHealth is the use of information and communication technologies for health. mHealth is the use of mobile technology in health. As with all information technology (IT), advances in development are rapidly taking place. The application of such technology to individual ambulatory anaesthesia practice should improve the ...

  10. Rapidly variable relatvistic absorption (United States)

    Parker, M.; Pinto, C.; Fabian, A.; Lohfink, A.; Buisson, D.; Alston, W.; Jiang, J.


    I will present results from the 1.5Ms XMM-Newton observing campaign on the most X-ray variable AGN, IRAS 13224-3809. We find a series of nine absorption lines with a velocity of 0.24c from an ultra-fast outflow. For the first time, we are able to see extremely rapid variability of the UFO features, and can link this to the X-ray variability from the inner accretion disk. We find a clear flux dependence of the outflow features, suggesting that the wind is ionized by increasing X-ray emission.

  11. Rapid prototype and test

    Energy Technology Data Exchange (ETDEWEB)

    Gregory, D.L.; Hansche, B.D.


    In order to support advanced manufacturing, Sandia has acquired the capability to produce plastic prototypes using stereolithography. Currently, these prototypes are used mainly to verify part geometry and ``fit and form`` checks. This project investigates methods for rapidly testing these plastic prototypes, and inferring from prototype test data actual metal part performance and behavior. Performances examined include static load/stress response, and structural dynamic (modal) and vibration behavior. The integration of advanced non-contacting measurement techniques including scanning laser velocimetry, laser holography, and thermoelasticity into testing of these prototypes is described. Photoelastic properties of the epoxy prototypes to reveal full field stress/strain fields are also explored.

  12. Right-Rapid-Rough (United States)

    Lawrence, Craig


    IDEO (pronounced 'eye-dee-oh') is an international design, engineering, and innovation firm that has developed thousands of products and services for clients across a wide range of industries. Its process and culture attracted the attention of academics, businesses, and journalists around the world, and are the subject of a bestselling book, The Art of Innovation by Tom Kelley. One of the keys to IDEO's success is its use of prototyping as a tool for rapid innovation. This story covers some of IDEO's projects, and gives reasons for why they were successful.

  13. Learning Technology standardizaion

    NARCIS (Netherlands)

    Sloep, Peter


    Trying to acquaint oneself with the learning technology standardisationarea rapidly becomes a bewildering experience.Acronyms and organisations abound, a search for firm grounds on who decides what seems futile, and the gurus contradict each other. This short paper by Peter Sloep provides some

  14. Rapid mineralocorticoid receptor trafficking. (United States)

    Gekle, M; Bretschneider, M; Meinel, S; Ruhs, S; Grossmann, C


    The mineralocorticoid receptor (MR) is a ligand-dependent transcription factor that physiologically regulates water-electrolyte homeostasis and controls blood pressure. The MR can also elicit inflammatory and remodeling processes in the cardiovascular system and the kidneys, which require the presence of additional pathological factors like for example nitrosative stress. However, the underlying molecular mechanism(s) for pathophysiological MR effects remain(s) elusive. The inactive MR is located in the cytosol associated with chaperone molecules including HSP90. After ligand binding, the MR monomer rapidly translocates into the nucleus while still being associated to HSP90 and after dissociation from HSP90 binds to hormone-response-elements called glucocorticoid response elements (GREs) as a dimer. There are indications that rapid MR trafficking is modulated in the presence of high salt, oxidative or nitrosative stress, hypothetically by induction or posttranslational modifications. Additionally, glucocorticoids and the enzyme 11beta hydroxysteroid dehydrogenase may also influence MR activation. Because MR trafficking and its modulation by micro-milieu factors influence MR cellular localization, it is not only relevant for genomic but also for nongenomic MR effects. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Rapid typing of Coxiella burnetii.

    Directory of Open Access Journals (Sweden)

    Heidie M Hornstra

    Full Text Available Coxiella burnetii has the potential to cause serious disease and is highly prevalent in the environment. Despite this, epidemiological data are sparse and isolate collections are typically small, rare, and difficult to share among laboratories as this pathogen is governed by select agent rules and fastidious to culture. With the advent of whole genome sequencing, some of this knowledge gap has been overcome by the development of genotyping schemes, however many of these methods are cumbersome and not readily transferable between institutions. As comparisons of the few existing collections can dramatically increase our knowledge of the evolution and phylogeography of the species, we aimed to facilitate such comparisons by extracting SNP signatures from past genotyping efforts and then incorporated these signatures into assays that quickly and easily define genotypes and phylogenetic groups. We found 91 polymorphisms (SNPs and indels among multispacer sequence typing (MST loci and designed 14 SNP-based assays that could be used to type samples based on previously established phylogenetic groups. These assays are rapid, inexpensive, real-time PCR assays whose results are unambiguous. Data from these assays allowed us to assign 43 previously untyped isolates to established genotypes and genomic groups. Furthermore, genotyping results based on assays from the signatures provided here are easily transferred between institutions, readily interpreted phylogenetically and simple to adapt to new genotyping technologies.

  16. Rapid Refresh (RAP) [13 km (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

  17. Rapid Refresh (RAP) [20 km (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

  18. Rapid chemical separations

    CERN Document Server

    Trautmann, N


    A survey is given on the progress of fast chemical separation procedures during the last few years. Fast, discontinuous separation techniques are illustrated by a procedure for niobium. The use of such techniques for the chemical characterization of the heaviest known elements is described. Other rapid separation methods from aqueous solutions are summarized. The application of the high speed liquid chromatography to the separation of chemically similar elements is outlined. The use of the gas jet recoil transport method for nuclear reaction products and its combination with a continuous solvent extraction technique and with a thermochromatographic separation is presented. Different separation methods in the gas phase are briefly discussed and the attachment of a thermochromatographic technique to an on-line mass separator is shown. (45 refs).

  19. Dynamics of rapid innovation

    CERN Document Server

    Fink, T M A; Palma, R; Farr, R S


    We introduce a model of innovation in which products are composed of components and new components are adopted one at a time. We show that the number of products we can make now gives a distorted view of the number we can make in the future: the more complex a product is, the more it gets under-represented. From this complexity discount we derive a strategy for increasing the rate of innovation by choosing components on the basis of long-term growth rather than just short-term gain. We test our model on data from language, gastronomy and technology and predict the best strategy for innovating in each.

  20. Rapid prototyping tools


    Birkeland, Petter I


    This paper is the description of the method and result of the master project of Petter Ildgruben at the Department of Engineering Design and Materials (IPM) at the Norwegian University of Science and Technology (NTNU) in the spring of 2016. The goal of this master s thesis has been to explore the barriers that novel users face in makerspaces, specifically when interacting with the 3D printer, the laser cutter and the Computer Numerical Control (CNC) mill and how to overcome them. The first...

  1. Rapid Prototyping and its Application in Dentistry

    Directory of Open Access Journals (Sweden)

    V. N. V. Madhav


    Full Text Available Medical implants and biological models have three main characteristics: low volume, complex shape, and can be customized. These characteristics suit very well with Rapid Prototyping (RP and Rapid Manufacturing (RM processes. RP/RM processes are fabricated part layer- by-layer until complete shape finished from 3D model. Biocompatible materials, such as Titanium and Titanium alloy, Zirconium, Cobalt Chromium, PEEK, etc, are used for fabrication process. Reverse Engineering (RE technology greatly affects RP/RM processes. RE is used to capture or scan image of the limb, cranium, tooth, and other biological objects. Three common methods to get the image are 3D laser scanning, Computer Tomography (CT, and Magnetic Resonance Imaging (MRI. Main RP/RM techniques used in Dentistry are Stereotype Lithography Apparatus (SLA, Fused Deposition Modeling (FDM, Selective Laser Sintering (SLS, and ink jet printing. This article reviews the changing scenario of technology in dentistry with special emphasis on Rapid Prototyping and its various applications in Dentistry.

  2. RAPID: Collaborative Commanding and Monitoring of Lunar Assets (United States)

    Torres, Recaredo J.; Mittman, David S.; Powell, Mark W.; Norris, Jeffrey S.; Joswig, Joseph C.; Crockett, Thomas M.; Abramyan, Lucy; Shams, Khawaja S.; Wallick, Michael; Allan, Mark; hide


    RAPID (Robot Application Programming Interface Delegate) software utilizes highly robust technology to facilitate commanding and monitoring of lunar assets. RAPID provides the ability for intercenter communication, since these assets are developed in multiple NASA centers. RAPID is targeted at the task of lunar operations; specifically, operations that deal with robotic assets, cranes, and astronaut spacesuits, often developed at different NASA centers. RAPID allows for a uniform way to command and monitor these assets. Commands can be issued to take images, and monitoring is done via telemetry data from the asset. There are two unique features to RAPID: First, it allows any operator from any NASA center to control any NASA lunar asset, regardless of location. Second, by abstracting the native language for specific assets to a common set of messages, an operator may control and monitor any NASA lunar asset by being trained only on the use of RAPID, rather than the specific asset. RAPID is easier to use and more powerful than its predecessor, the Astronaut Interface Device (AID). Utilizing the new robust middleware, DDS (Data Distribution System), developing in RAPID has increased significantly over the old middleware. The API is built upon the Java Eclipse Platform, which combined with DDS, provides platform-independent software architecture, simplifying development of RAPID components. As RAPID continues to evolve and new messages are being designed and implemented, operators for future lunar missions will have a rich environment for commanding and monitoring assets.

  3. Building a rapid response team. (United States)

    Halvorsen, Lisa; Garolis, Salomeja; Wallace-Scroggs, Allyson; Stenstrom, Judy; Maunder, Richard


    The use of rapid response teams is a relatively new approach for decreasing or eliminating codes in acute care hospitals. Based on the principles of a code team for cardiac and/or respiratory arrest in non-critical care units, the rapid response teams have specially trained nursing, respiratory, and medical personnel to respond to calls from general care units to assess and manage decompensating or rapidly changing patients before their conditions escalate to a full code situation. This article describes the processes used to develop a rapid response team, clinical indicators for triggering a rapid response team call, topics addressed in an educational program for the rapid response team members, and methods for evaluating effectiveness of the rapid response team.

  4. Rapid prototyping with high power fiber lasers

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, R.M. [Faculty of Sciences and Technology, New University Lisbon (Portugal); IDMEC, Instituto Superior Tecnico, TULISBON, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Lopes, G. [Welding Engineering Research Centre, Building 46, Cranfield University, Bedfordshire, MK43 0AL (United Kingdom); Quintino, L. [IDMEC, Instituto Superior Tecnico, TULISBON, Av. Rovisco Pais, 1049-001 Lisboa (Portugal)], E-mail:; Rodrigues, J.P. [IDMEC, Instituto Superior Tecnico, TULISBON, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Williams, S. [Welding Engineering Research Centre, Building 46, Cranfield University, Bedfordshire, MK43 0AL (United Kingdom)


    Laser rapid prototyping technologies comprise a set of technologies used in a wide range of materials to produce prototypes or small batches of complex shaped components. This paper presents a research work on rapid prototyping technology with laser additive manufacture of wire based alloy Ti-6Al-4V with an 8 kW fiber laser for the production of components with cylindrical geometry. For this, an engineering system was developed, a demonstration part produced and the deposition process was characterized. Two processing parameters were investigated: and these were the relative position between the wire feeding system and the substrate and the laser beam to wire width ratio. The former affects the molten metal transfer mode and the pressure exerted by the wire tip on the molten pool, while the laser beam to wire width ratio affects the process efficiency, since this is a compromise of process stability and process speed. Both parameters control surface finishing and the smoothness of the part. The melting efficiency of the process is low when compared to alternative processes involving powder pre deposition, but the density of the part is improved with homogeneous structural characteristics.

  5. Problems of rapid growth. (United States)

    Kim, T D


    South Korea's export-oriented development strategy has achieved a remarkable growth record, but it has also brought 2 different problems: 1) since the country's exports accounted for about 1% of total world export volume, the 1st world has become fearful about Korea's aggressive export drive; and 2) the fact that exports account for over 30% of its total gross national product (GNP) exposes the vulnerability of South Korea's economy itself. South Korea continues to be a poor nation, although it is rated as 1 of the most rapidly growing middle income economies. A World Bank 1978 report shows Korea to be 28th of 58 middle income countries in terms of per capita GNP in 1976. Of 11 newly industrializing countries (NIC), 5 in the European continent are more advanced than the others. A recent emphasis on the basic human needs approach has tended to downgrade the concept of GNP. Korea has only an abundant labor force and is without any natural resources. Consequently, Korea utilized an export-oriented development strategy. Oil requirements are met with imports, and almost all raw materials to be processed into exportable products must be imported. To pay import bills Korea must export and earn foreign exchange. It must be emphasized that foreign trade must always be 2-way traffic. In order to export more to middle income countries like Korea, the countries of the 1st world need to ease their protectionist measures against imports from developing countries.

  6. Rapid Polymer Sequencer (United States)

    Stolc, Viktor (Inventor); Brock, Matthew W (Inventor)


    Method and system for rapid and accurate determination of each of a sequence of unknown polymer components, such as nucleic acid components. A self-assembling monolayer of a selected substance is optionally provided on an interior surface of a pipette tip, and the interior surface is immersed in a selected liquid. A selected electrical field is impressed in a longitudinal direction, or in a transverse direction, in the tip region, a polymer sequence is passed through the tip region, and a change in an electrical current signal is measured as each polymer component passes through the tip region. Each of the measured changes in electrical current signals is compared with a database of reference electrical change signals, with each reference signal corresponding to an identified polymer component, to identify the unknown polymer component with a reference polymer component. The nanopore preferably has a pore inner diameter of no more than about 40 nm and is prepared by heating and pulling a very small section of a glass tubing.

  7. Rapidly rotating red giants (United States)

    Gehan, Charlotte; Mosser, Benoît; Michel, Eric


    Stellar oscillations give seismic information on the internal properties of stars. Red giants are targets of interest since they present mixed modes, wich behave as pressure modes in the convective envelope and as gravity modes in the radiative core. Mixed modes thus directly probe red giant cores, and allow in particular the study of their mean core rotation. The high-quality data obtained by CoRoT and Kepler satellites represent an unprecedented perspective to obtain thousands of measurements of red giant core rotation, in order to improve our understanding of stellar physics in deep stellar interiors. We developed an automated method to obtain such core rotation measurements and validated it for stars on the red giant branch. In this work, we particularly focus on the specific application of this method to red giants having a rapid core rotation. They show complex spectra where it is tricky to disentangle rotational splittings from mixed-mode period spacings. We demonstrate that the method based on the identification of mode crossings is precise and efficient. The determination of the mean core rotation directly derives from the precise measurement of the asymptotic period spacing ΔΠ1 and of the frequency at which the crossing of the rotational components is observed.

  8. Rapid prototyping: An innovative technique in dentistry

    Directory of Open Access Journals (Sweden)

    Shakeba Quadri


    Full Text Available Emergence of advanced digital technology has opened up new perspectives for design and production in the field of dentistry. Rapid prototyping (RP is a technique to quickly and automatically construct a three-dimensional (3D model of a part or product using 3D printers or stereolithography machines. RP has various dental applications, such as fabrication of implant surgical guides, zirconia prosthesis and molds for metal castings, maxillofacial prosthesis and frameworks for fixed and removable partial dentures, wax patterns for the dental prosthesis and complete denture. Rapid prototyping presents fascinating opportunities, but the process is difficult as it demands a high level of artistic skill, which means that the dental technicians should be able to work with the models obtained after impression to form a mirror image and achieve good esthetics. This review aims to focus on various RP methods and its application in dentistry.

  9. Low-density microarray technologies for rapid human norovirus genotyping (United States)

    Human noroviruses cause up to 21 million cases of foodborne disease in the United States annually and are the most common cause of acute gastroenteritis in industrialized countries. To reduce the burden of foodborne disease associated with viruses, the use of low density DNA microarrays in conjuncti...

  10. Evidence-based medicine in rapidly changing technologies

    DEFF Research Database (Denmark)

    Schroeder, Torben Veith


    Evidence-based medicine (EBM) is not a randomised controlled trial (RCT), but EBM seeks to apply evidence gained from scientific methods - which could be RCT - to daily medical practice. Any surgical treatment reflects a certain development technically as well as skills based. The procedure may...

  11. Rapid bridge construction technology : precast elements for substructures. (United States)


    The goal of this research was to propose an alternate system of precast bridge substructures which can : substitute for conventional cast in place systems in Wisconsin to achieve accelerated construction. : Three types of abutment modules (hollow wal...

  12. Methods and systems for rapid prototyping of high density circuits (United States)

    Palmer, Jeremy A [Albuquerque, NM; Davis, Donald W [Albuquerque, NM; Chavez, Bart D [Albuquerque, NM; Gallegos, Phillip L [Albuquerque, NM; Wicker, Ryan B [El Paso, TX; Medina, Francisco R [El Paso, TX


    A preferred embodiment provides, for example, a system and method of integrating fluid media dispensing technology such as direct-write (DW) technologies with rapid prototyping (RP) technologies such as stereolithography (SL) to provide increased micro-fabrication and micro-stereolithography. A preferred embodiment of the present invention also provides, for example, a system and method for Rapid Prototyping High Density Circuit (RPHDC) manufacturing of solderless connectors and pilot devices with terminal geometries that are compatible with DW mechanisms and reduce contact resistance where the electrical system is encapsulated within structural members and manual electrical connections are eliminated in favor of automated DW traces. A preferred embodiment further provides, for example, a method of rapid prototyping comprising: fabricating a part layer using stereolithography and depositing thermally curable media onto the part layer using a fluid dispensing apparatus.

  13. MR sequences and rapid acquisition for MR guided interventions (United States)

    Campbell-Washburn, Adrienne E; Faranesh, Anthony Z; Lederman, Robert J; Hansen, Michael S


    Synopsis Interventional MR uses rapid imaging to guide diagnostic and therapeutic procedures. One of the attractions of MR-guidance is the abundance of inherent contrast mechanisms available. Dynamic procedural guidance with real-time imaging has pushed the limits of MR technology, demanding rapid acquisition and reconstruction paired with interactive control and device visualization. This article reviews the technical aspects of real-time MR sequences that enable MR-guided interventions. PMID:26499283

  14. Rapid mixing kinetic techniques. (United States)

    Martin, Stephen R; Schilstra, Maria J


    Almost all of the elementary steps in a biochemical reaction scheme are either unimolecular or bimolecular processes that frequently occur on sub-second, often sub-millisecond, time scales. The traditional approach in kinetic studies is to mix two or more reagents and monitor the changes in concentrations with time. Conventional spectrophotometers cannot generally be used to study reactions that are complete within less than about 20 s, as it takes that amount of time to manually mix the reagents and activate the instrument. Rapid mixing techniques, which generally achieve mixing in less than 2 ms, overcome this limitation. This chapter is concerned with the use of these techniques in the study of reactions which reach equilibrium; the application of these methods to the study of enzyme kinetics is described in several excellent texts (Cornish-Bowden, Fundamentals of enzyme kinetics. Portland Press, 1995; Gutfreund, Kinetics for the life sciences. Receptors, transmitters and catalysis. Cambridge University Press, 1995).There are various ways to monitor changes in concentration of reactants, intermediates and products after mixing, but the most common way is to use changes in optical signals (absorbance or fluorescence) which often accompany reactions. Although absorbance can sometimes be used, fluorescence is often preferred because of its greater sensitivity, particularly in monitoring conformational changes. Such methods are continuous with good time resolution but they seldom permit the direct determination of the concentrations of individual species. Alternatively, samples may be taken from the reaction volume, mixed with a chemical quenching agent to stop the reaction, and their contents assessed by techniques such as HPLC. These methods can directly determine the concentrations of different species, but are discontinuous and have a limited time resolution.

  15. Rapid prototyping of composite aircraft structures (United States)

    Bennett, George; Rais-Rohani, Masoud; Hall, Kenneth; Holifield, Walt; Sullivan, Rani; Brown, Scott

    The faculty, staff and students of the Raspet Flight Research Laboratory (RFRL) have developed a rapid prototyping capability in a series of research aircraft and unmanned aircraft development projects. There has been a steady change in the technologies used to accomplish these tasks at the RFRL. The most recent development has been the utilization of computer graphics and a 5-axis gantry robot router to accelerate the design, moldmaking and parts trimming tasks. The composite structure fabrication processes at the RFRL have evolved from wet-lay-up to autoclave curve. Currently, the feasibility of the stitched composite material preform and resin transfer molding process is being explored.

  16. Rapid Response Manufacturing (RRM). Final CRADA report

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)


    A major accomplishment of the Rapid Response Manufacturing (RRM) project was the development of a broad-based generic framework for automating and integrating the design-to-manufacturing activities associated with machined part products. Key components of the framework are a manufacturing model that integrates product and process data in a consistent, minimally redundant manner, an advanced computer-aided engineering working environment, knowledge-based software systems for design, process planning, and manufacturing and new production technologies for making products directly from design application software.

  17. Sport Technology

    CSIR Research Space (South Africa)

    Kirkbride, T


    Full Text Available Technology is transforming the games themselves and at times with dire consequences. Tony Kirkbride, Head: CSIR Technology Centre said there are a variety of sports technologies and there have been advances in material sciences and advances...

  18. Assistive Technology (United States)

    ... Page Resize Text Printer Friendly Online Chat Assistive Technology Assistive technology (AT) is any service or tool that helps ... be difficult or impossible. For older adults, such technology may be a walker to improve mobility or ...

  19. Use of Educational Technologies to assist Academics in their ...

    African Journals Online (AJOL)

    In the ever changing world of technology, traditional ways of doing classes have been greatly overtaken by the integration of educational technologies in the curriculum. In this digital era, with rapid technological innovations, the learning and teaching process is also changing rapidly at tertiary level. The use of educational ...

  20. Handbook of antenna technologies

    CERN Document Server

    Liu, Duixian; Nakano, Hisamatsu; Qing, Xianming; Zwick, Thomas


    The Handbook of Antenna Technologies aims to present the rapid development of antenna technologies, particularly in the past two decades, and also showcasing the newly developed technologies and the latest applications. The handbook will provide readers with the comprehensive updated reference information covering theory, modeling and optimization methods, design and measurement, new electromagnetic materials, and applications of antennas. The handbook will widely cover not only all key antenna design issues but also fundamentals, issues related to antennas (transmission, propagation, feeding structure, materials, fabrication, measurement, system, and unique design challenges in specific applications). This handbook will benefit the readers as a full and quick technical reference with a high-level historic review of technology, detailed technical descriptions and the latest practical applications.

  1. RapidIO as a multi-purpose interconnect (United States)

    Baymani, Simaolhoda; Alexopoulos, Konstantinos; Valat, Sébastien


    RapidIO ( technology is a packet-switched high-performance fabric, which has been under active development since 1997. Originally meant to be a front side bus, it developed into a system level interconnect which is today used in all 4G/LTE base stations world wide. RapidIO is often used in embedded systems that require high reliability, low latency and scalability in a heterogeneous environment - features that are highly interesting for several use cases, such as data analytics and data acquisition (DAQ) networks. We will present the results of evaluating RapidIO in a data analytics environment, from setup to benchmark. Specifically, we will share the experience of running ROOT and Hadoop on top of RapidIO. To demonstrate the multi-purpose characteristics of RapidIO, we will also present the results of investigating RapidIO as a technology for high-speed DAQ networks using a generic multi-protocol event-building emulation tool. In addition we will present lessons learned from implementing native ports of CERN applications to RapidIO.

  2. Technology Transience and the Challenges It Poses to Higher Education (United States)

    Amirault, Ray J.


    Today's technologies come and go at an alarming rate, and the length of time any one technology, either software or hardware, exists before being supplanted by a newer technology is growing ever shorter. For anyone working within the field of instructional technology, this rapid replacement rate of technologies can hold immense implications for…

  3. Parent Involvement, Technology, and Media: Now What? (United States)

    Patrikakou, Eva N.


    The rapid technological advances, the expansion of online media use, and the declining cost of mobile technology have introduced a communication factor that has precipitously affected parent involvement and the relationship between parents and children. The present article explores ways through which technology and online media have affected…

  4. Handbook of surveillance technologies

    CERN Document Server

    Petersen, JK


    From officially sanctioned, high-tech operations to budget spy cameras and cell phone video, this updated and expanded edition of a bestselling handbook reflects the rapid and significant growth of the surveillance industry. The Handbook of Surveillance Technologies, Third Edition is the only comprehensive work to chronicle the background and current applications of the full-range of surveillance technologies--offering the latest in surveillance and privacy issues.Cutting-Edge--updates its bestselling predecessor with discussions on social media, GPS circuits in cell phones and PDAs, new GIS s

  5. Information technology and management


    Afërdita Berisha-Shaqiri


    The rapid development of information technology has influenced informatics as an important role in business development and management. Manifestations of computerization in the current economy mostly reflect the application of information systems for planning and strategic different analysis, especially when making long-term decisions. These systems consist of several information systems and management control systems for decision support. The construction of these systems was originally a re...

  6. Environmental Stress Screening Technology. (United States)


    2402 04 47 11 TITLE (Includ& Security Classofication) Environmental Stress Screening Technology 12 PRSONAL AUTOR(S) Quartin, Herbert; Kube, Frank...Infrared (IR), Environmental Stress Screening, 09 03 Thermography, Acceptance Testing, Electronics 14 i _ .. .. 19 ABSTRACT (Continue on reverse of...become a necessity (Ref I and 2). A principal driver of the effectiveness of Environmental Stress Screening (ESS) is the ability to rapidly and

  7. Breaking the addiction to technology adoption. (United States)

    Bryan, Stirling; Mitton, Craig; Donaldson, Cam


    A major driver of cost growth in health care is the rapid increase in the utilisation of existing technology and not simply the adoption of new technology. Health economists and their health technology assessment colleagues have become obsessed by technology adoption questions and have largely ignored 'technology management' questions. Technology management would include the life-cycle assessment of technologies in use, to assess their real-world performance; and monitoring of technology indication creep. A rebalancing of focus might serve to encourage a more self-critical and learning culture amongst those involved in technology evaluation analysis. Further, health economists and health technology assessment analysts could make a more significant contribution to system efficiency through rebalancing their efforts away from technology adoption questions towards technology management issues. Copyright © 2014 John Wiley & Sons, Ltd.

  8. Sheet metal forming using rapid prototyped tooling (United States)

    Park, Young-Bin

    The demand for rapid, low-cost die fabrication and modification technology is greater than ever in sheet metal forming industry. One category of rapid tooling technology involves the application of advanced polymers and composites to fabricate metal forming dies. Despite their advantages in lead time and cost reductions, polymer dies for sheet metal forming applications have several drawbacks. Due to their lack of strength as compared to conventional die materials, the use of polymer dies is often limited to prototype or short-run production. In addition, because the mechanisms by which they fail are not fully understood, the dies are designed on the basis of experience and intuition. The research (1) characterized the mechanical behavior of an advanced polymer composite tooling material, (2) developed a method to predict the failure mode and the life of a polymer die, and (3) established optimal die design guidelines. The focus was on rapid prototyped, aluminum trihydrate(ATH)-filled, polyurethane-based dies in sheet metal forming. The study involved the determination of dominant process parameters based on the finite element analyses of 90° V-die bending and cylindrical cup drawing processes. The effects of process parameters on stress distribution in the die provided guidelines to the modification of die design for achieving the desired die life. The presented parametric study lays the groundwork for providing reliable tool failure prediction and design optimization guidelines for advanced polymer tooling materials in metal forming. In addition, the failure mechanisms were investigated to predict the failure mode and the fatigue life of the die. To establish a fundamental understanding of the fatigue behavior of the polyurethane-based die material, extensive material tests were performed, the microstructure was studied, and the fatigue properties were identified experimentally. The test data were incorporated into the local stress-based fatigue analysis to

  9. Sensemaking technologies

    DEFF Research Database (Denmark)

    Madsen, Charlotte Øland

    Research scope: The scope of the project is to study technological implementation processes by using Weick's sensemaking concept (Weick, 1995). The purpose of using a social constructivist approach to investigate technological implementation processes is to find out how new technologies transform...... technologies results in emerging changes in the organisation's social networks and roles and how these changes affect the organisation's use of new technology (Barley 1986; 1990: Compton, White & DeWine 1991; Orlikowski 2000,)....

  10. Technology for Peacebuilding

    Directory of Open Access Journals (Sweden)

    Helena Puig Larrauri


    Full Text Available New technologies are changing how and when we learn about events and choose to respond to them. Mobile phones and the internet have altered how we engage with the world. With technology usage expanding rapidly in the developing world, new avenues of participation, engagement, and accountability are emerging. Globally, more people now have the opportunity to actively make use of these tools to participate in processes that impact their societies. This opportunity for participation is also an opportunity for engaging in new ways with peacebuilding processes. As the field of technology for peacebuilding grows, most attention has been paid to the potential of new technologies for bridging the gap between warning and response. Whilst the focus on the use of technology for early warning and response is important, there is more to this growing field. The empowerment of people to participate in localized conflict management efforts is one of the most significant innovations and opportunities created by new technologies. Technology can contribute to peacebuilding processes by offering tools that foster collaboration, transform attitudes, and give a stronger voice to communities. This article aims to give practitioners two related frameworks to understand how new technologies can enhance peacebuilding. The first section looks at the functions that technology can have in a peacebuilding program as a tool for data processing, communication, engagement, and gaming. We then examine the program areas that new technologies can best contribute to, covering early warning/early response systems, programs that allow citizens to voice their opinions and experiences, collaboration efforts, and programs aimed at transforming attitudes.

  11. How Rapid is Rapid Prototyping? Analysis of ESPADON Programme Results

    Directory of Open Access Journals (Sweden)

    Ian D. Alston


    Full Text Available New methodologies, engineering processes, and support environments are beginning to emerge for embedded signal processing systems. The main objectives are to enable defence industry to field state-of-the-art products in less time and with lower costs, including retrofits and upgrades, based predominately on commercial off the shelf (COTS components and the model-year concept. One of the cornerstones of the new methodologies is the concept of rapid prototyping. This is the ability to rapidly and seamlessly move from functional design to the architectural design to the implementation, through automatic code generation tools, onto real-time COTS test beds. In this paper, we try to quantify the term “rapid” and provide results, the metrics, from two independent benchmarks, a radar and sonar beamforming application subset. The metrics show that the rapid prototyping process may be sixteen times faster than a conventional process.

  12. Rapid Analysis Model: Reducing Analysis Time without Sacrificing Quality. (United States)

    Lee, William W.; Owens, Diana


    Discusses the performance technology design process and the fact that the analysis phase is often being eliminated to speed up the process. Proposes a rapid analysis model that reduces time needed for analysis and still ensures more successful value-added solutions that focus on customer satisfaction. (LRW)

  13. Influence of quench rates on the properties of rapidly solidified ...

    Indian Academy of Sciences (India)


    A K PANDA, I CHATTORAJ, S BASU* and A MITRA. National Metallurgical Laboratory, Jamshedpur 831 007, India. *Materials Science Centre, Indian Institute of Technology, Kharagpur 721 302, India. Abstract. FeNbCuSiB based materials were produced in the form of ribbons by rapid solidification techniques.

  14. Developing Collective Learning Extension for Rapidly Evolving Information System Courses (United States)

    Agarwal, Nitin; Ahmed, Faysal


    Due to rapidly evolving Information System (IS) technologies, instructors find themselves stuck in the constant game of catching up. On the same hand students find their skills obsolete almost as soon as they graduate. As part of IS curriculum and education, we need to emphasize more on teaching the students "how to learn" while keeping…

  15. Development and implementation of a rapid real-time polymerase ...

    African Journals Online (AJOL)

    Assays which use real-time polymerase chain reaction (PCR) technology can be developed for the rapid identification of genetic sequences carried by waterborne pathogens. Rand Water has established facilities within which a selection of PCR assays will be developed. This paper reports on the optimisation and ...

  16. Rapid Prototyping of Electrically Small Spherical Wire Antennas

    DEFF Research Database (Denmark)

    Kim, Oleksiy S.


    It is shown how modern rapid prototyping technologies can be applied for quick and inexpensive, but still accurate, fabrication of electrically small wire antennas. A well known folded spherical helix antenna and a novel spherical zigzag antenna have been fabricated and tested, exhibiting the imp...

  17. Profitability of a Smallholder Late Season Rapid Multiplication of ...

    African Journals Online (AJOL)

    The study investigated the effects of increasing poultry manure rates on the soil physicochemical properties, crop productivity and economic returns to investment of late season rapid multiplication of cassava stem enterprise at the Teaching and Research Farm, Federal University of Technology, Owerri in the humid ...

  18. Response of some elite cocoyam varieties to cocoyam rapid ...

    African Journals Online (AJOL)

    The experiment on the response of some elite cocoyam varieties to cocoyam rapid multiplication technology was carried out in 2012 and 2013 at the Research field of the National Root Crops Research Institute Umudike. Treatment comprised M1, M2 (microcormels from colocasia spp and Xanthosoma spp respectively); ...

  19. Nanomaterial-enabled Rapid Detection of Water Contaminants. (United States)

    Mao, Shun; Chang, Jingbo; Zhou, Guihua; Chen, Junhong


    Water contaminants, e.g., inorganic chemicals and microorganisms, are critical metrics for water quality monitoring and have significant impacts on human health and plants/organisms living in water. The scope and focus of this review is nanomaterial-based optical, electronic, and electrochemical sensors for rapid detection of water contaminants, e.g., heavy metals, anions, and bacteria. These contaminants are commonly found in different water systems. The importance of water quality monitoring and control demands significant advancement in the detection of contaminants in water because current sensing technologies for water contaminants have limitations. The advantages of nanomaterial-based sensing technologies are highlighted and recent progress on nanomaterial-based sensors for rapid water contaminant detection is discussed. An outlook for future research into this rapidly growing field is also provided. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Human Spaceflight Technology Needs - A Foundation for JSC's Technology Strategy (United States)

    Stecklein, Jonette M.


    Human space exploration has always been heavily influenced by goals to achieve a specific mission on a specific schedule. This approach drove rapid technology development, the rapidity of which adds risks as well as provides a major driver for costs and cost uncertainty. The National Aeronautics and Space Administration (NASA) is now approaching the extension of human presence throughout the solar system by balancing a proactive yet less schedule-driven development of technology with opportunistic scheduling of missions as the needed technologies are realized. This approach should provide cost effective, low risk technology development that will enable efficient and effective manned spaceflight missions. As a first step, the NASA Human Spaceflight Architecture Team (HAT) has identified a suite of critical technologies needed to support future manned missions across a range of destinations, including in cis-lunar space, near earth asteroid visits, lunar exploration, Mars moons, and Mars exploration. The challenge now is to develop a strategy and plan for technology development that efficiently enables these missions over a reasonable time period, without increasing technology development costs unnecessarily due to schedule pressure, and subsequently mitigating development and mission risks. NASA's Johnson Space Center (JSC), as the nation s primary center for human exploration, is addressing this challenge through an innovative approach in allocating Internal Research and Development funding to projects. The HAT Technology Needs (TechNeeds) Database has been developed to correlate across critical technologies and the NASA Office of Chief Technologist Technology Area Breakdown Structure (TABS). The TechNeeds Database illuminates that many critical technologies may support a single technical capability gap, that many HAT technology needs may map to a single TABS technology discipline, and that a single HAT technology need may map to multiple TABS technology

  1. [Modern technology in cardiovascular medicine]. (United States)

    Bolz, A


    Despite basic physiologic principles being well known for more than 300 years, the diagnosis and therapy of cardiovascular diseases are still in their early beginnings. For example, 100 years ago sudden cardiac arrest was regarded as the result of toxic gases. The diagnosis of ventricular fibrillation or treatment with a defibrillator are very recent developments. We are currently experiencing a technological revolution, which is rapidly changing cardiovascular medicine. This publication is focused on electrical devices and tries to identify some of the innovation mainstreams using a few examples to demonstrate these. Four megatrends are explained in more detail: the influence of wireless technology, information technology, micro systems technology, and thinking in systems. This paper is aimed at stimulating active researchers and engineers to detect the rapid changes that we often do not observe in our daily work. The author hopes that this stimulation will lead to new ideas and combinations.

  2. A Rapid Coliform Detector Project (United States)

    National Aeronautics and Space Administration — ORBITEC, in collaboration with Lucigen, proposes a rapid genetic detector for spaceflight water systems to enable real-time detection of E-coli with minimal...

  3. Rapid Multiplex Microbial Detector Project (United States)

    National Aeronautics and Space Administration — ORBITEC, in collaboration with Lucigen, proposes a rapid nucleic acid-based detector for spaceflight water systems to enable simultaneous quantification of multiple...

  4. Challenges of cloud technology in manufacturing environment


    Yadekar, Yaser; Shehab, Essam; Mehnen, Jorn


    The rapid growth Information systems and advanced network technologies have significant impact on enterprises around the world. Enterprises are trying to gain competitive advantage in open global markets by using the latest technologies, along with advanced networks, to create collaboration, reduce costs, and maximize productivity. The combination of latest technologies and advanced manufacturing networks technologies lead to growth of new manufacturing model named Cloud Manufacturing which c...

  5. Technological Advances in Nursing Care Delivery. (United States)

    Sullivan, Debra Henline


    Technology is rapidly changing the way nurses deliver patient care. The Health Information Technology for Economic and Clinical Health Act of 2009 encourages health care providers to implement electronic health records for meaningful use of patient information. This development has opened the door to many technologies that use this information to streamline patient care. This article explores current and new technologies that nurses will be working with either now or in the near future. Copyright © 2015 Elsevier Inc. All rights reserved.

  6. Technology Roadmap: Hydropower

    Energy Technology Data Exchange (ETDEWEB)



    Hydropower could double its contribution by 2050, reaching 2,000 GW of global capacity and over 7,000 TWh. This achievement, driven primarily by the quest of clean electricity, could prevent annual emissions of up to 3 billion tonnes of CO2 from fossil-fuel plants. The bulk of this growth would come from large plants in emerging economies and developing countries. Hydroelectricity’s many advantages include reliability, proven technology, large storage capacity, and very low operating and maintenance costs. Hydropower is highly flexible, a precious asset for electricity network operators, especially given rapid expansion of variable generation from other renewable energy technologies such as wind power and photovoltaics. Many hydropower plants also provide flood control, irrigation, navigation and freshwater supply. The technology roadmap for Hydropower details action needed from policy makers to allow hydroelectric production to double, and addresses necessary conditions, including resolving environmental issues and gaining public acceptance.

  7. Being technological (United States)

    Denning, Kathryn


    SETI's essential premises involve evolution in multiple domains: cosmology, biology, culture and technology. Comparatively little has been written about the last of these, technology, in relation to SETI's targets, but it is a crucial variable and well worth deep examination. In particular, it would seem prudent to consider carefully our assumptions about hypothetical extraterrestrial societies which have developed technology that SETI could detect, or which could detect, at interstellar distances, the existence of intelligent life on Earth. This paper contributes to that effort by reflecting upon our habits of projecting terracentric assumptions onto hypothetical worlds, exploring dominant narratives about technological development and presenting varied philosophical theories about the nature of technology. It highlights the cultural aspects of technology here on Earth, particularly their role in the development of radio technology. In the end, it is clear that technology need not develop along a prescribed, linear path; projections about extraterrestrial societies which rely on this assumption need to be reconsidered.

  8. Living Technology

    DEFF Research Database (Denmark)


    This book is aimed at anyone who is interested in learning more about living technology, whether coming from business, the government, policy centers, academia, or anywhere else. Its purpose is to help people to learn what living technology is, what it might develop into, and how it might impact...... our lives. The phrase 'living technology' was coined to refer to technology that is alive as well as technology that is useful because it shares the fundamental properties of living systems. In particular, the invention of this phrase was called for to describe the trend of our technology becoming...... increasingly life-like or literally alive. Still, the phrase has different interpretations depending on how one views what life is. This book presents nineteen perspectives on living technology. Taken together, the interviews convey the collective wisdom on living technology's power and promise, as well as its...

  9. Casting Technology. (United States)

    Wright, Michael D.; And Others


    Three articles discuss (1) casting technology as it relates to industry, with comparisons of shell casting, shell molding, and die casting; (2) evaporative pattern casting for metals; and (3) high technological casting with silicone rubber. (JOW)

  10. Globalization & technology

    DEFF Research Database (Denmark)

    Narula, Rajneesh

    Technology and globalization are interdependent processes. Globalization has a fundamental influence on the creation and diffusion of technology, which, in turn, affects the interdependence of firms and locations. This volume examines the international aspect of this interdependence at two levels...

  11. Solid modeling and applications rapid prototyping, CAD and CAE theory

    CERN Document Server

    Um, Dugan


    The lessons in this fundamental text equip students with the theory of Computer Assisted Design (CAD), Computer Assisted Engineering (CAE), the essentials of Rapid Prototyping, as well as practical skills needed to apply this understanding in real world design and manufacturing settings. The book includes three main areas: CAD, CAE, and Rapid Prototyping, each enriched with numerous examples and exercises. In the CAD section, Professor Um outlines the basic concept of geometric modeling, Hermite and Bezier Spline curves theory, and 3-dimensional surface theories as well as rendering theory. The CAE section explores mesh generation theory, matrix notion for FEM, the stiffness method, and truss Equations. And in Rapid Prototyping, the author illustrates stereo lithographic theory and introduces popular modern RP technologies. Solid Modeling and Applications: Rapid Prototyping, CAD and CAE Theory is ideal for university students in various engineering disciplines as well as design engineers involved in product...

  12. [Rapid identification system for seedlings of medicinal Chrysanthemum morifolium]. (United States)

    Mao, Pengfei; Guo, Qiaosheng; Wang, Tao; Shao, Qingsong


    To achieve the rapid identification for seedlings of medicinal Chrysanthemum morifolium, the discriminant equation was established and the software for rapid identification was designed. Leaf structure of medicinal Chrysanthemum of 12 cultivars was analyzed to establish the discriminant equation based on variance analysis and discriminant analysis. On this basis, the identification program and software (based on the python language) were designed. Through the analysis of variance and multiple comparisons for the 11 leaf parameter index data of 12 different cultivars, it was found that that the leaf parameters were significant different from each other and reached significant levels. The discriminant equation and the rapid identification software were set up based on the analysis of various indicators. The rapid identification system of seedlings of medicinal Chrysanthemum could be achieved through the establishment of discriminant equation combined with computer technology.

  13. Today's Training in the High Technology Arena (United States)

    Baylis, William T.


    To keep in tune with the rapidly changing 'Hardware' technology, it is imperative that all of the supporting components of a program's efforts reflect these increases in technology. To maintain a work force that keeps in tune with the ever increasing technology base, training needs to remain a major consideration in all types of organizations. This paper focuses on the area of training and education and suggests a reasonable, cost effective alternative to carrying the entire burden of developing, training and maintaining a workforce in a rapidly changing, highly technological environment.

  14. Touching the Future Technology for Autism?

    DEFF Research Database (Denmark)

    International interest in the use of assistive and ambient information and communication technologies to support people with a range of cognitive impairments is growing rapidly. Autism spectrum disorders (ASDs), which affect social skills, communicative abilities and behavior, are of particular...

  15. Assistive Technologies (United States)

    Auat Cheein, Fernando A., Ed.


    This book offers the reader new achievements within the Assistive Technology field made by worldwide experts, covering aspects such as assistive technology focused on teaching and education, mobility, communication and social interactivity, among others. Each chapter included in this book covers one particular aspect of Assistive Technology that…

  16. Technology Tiers

    DEFF Research Database (Denmark)

    Karlsson, Christer


    A technology tier is a level in a product system: final product, system, subsystem, component, or part. As a concept, it contrasts traditional “vertical” special technologies (for example, mechanics and electronics) and focuses “horizontal” feature technologies such as product characteristics...

  17. Earthing Technology

    NARCIS (Netherlands)

    Blok, Vincent


    In this article, we reflect on the conditions under which new technologies emerge in the Anthropocene and raise the question of how to conceptualize sustainable technologies therein. To this end, we explore an eco-centric approach to technology development, called biomimicry. We discuss opposing

  18. Rapid Detection of the Varicella Zoster Virus (United States)

    Lewis, Michelle P.; Harding, Robert


    1.Technology Description-Researchers discovered that when the Varicella Zoster Virus (VZV) reactivates from latency in the body, the virus is consistently present in saliva before the appearance of skin lesions. A small saliva sample is mixed with a specialized reagent in a test kit. If the virus is present in the saliva sample, the mixture turns a red color. The sensitivity and specificity emanates from an antibody-antigen reaction. This technology is a rapid, non-invasive, point of-of-care testing kit for detecting the virus from a saliva sample. The device is easy to use and can be used in clinics and in remote locations to quickly detect VZV and begin treatment with antiviral drugs. 2.Market Opportunity- RST Bioscience will be the first and only company to market a rapid, same day test kit for the detection of VZV in saliva. The RST detection test kit will have several advantages over existing, competitive technology. The test kit is self contained and laboratory equipment is not required for analysis of the sample. Only a single saliva sample is required to be taken instead of blood or cerebral spinal fluid. The test kit is portable, sterile and disposable after use. RST detection test kits require no electrical power or expensive storage equipment and can be used in remote locations. 3.Market Analysis- According to the CDC, it is estimated that 1 million cases of shingles occur each year in the U.S. with more than half over the age of sixty. There is a high demand for rapid diagnostics by the public. The point-of-care testing (POCT) market is growing faster than other segments of in vitro diagnostics. According to a July 2007 InteLab Corporation industry report the overall market for POCT was forecast to increase from $10.3 billion in 2005 to $18.7 billion by 2011. The market value of this test kit has not been determined. 4.Competition- The VZV vaccine prevents 50% of cases and reduces neuralgia by 66%. The most popular test detects VZV-specific IgM antibody

  19. Review, Selection and Installation of a Rapid Prototype Machine (United States)

    McEndree, Caryl


    The objective of this paper is to impress upon the reader the benefits and advantages of investing in rapid prototyping (additive manufacturing) technology thru the procurement of one or two new rapid prototyping machines and the creation of a new Prototype and Model Lab at the Kennedy Space Center (KSC). This new resource will be available to all of United Space Alliance, LLC (USA), enabling engineers from around the company to pursue a more effective means of communication and design with our co-workers, and our customer, the National Aeronautics and Space Administration (NASA). The Rapid Protoyping/3D printing industry mirrors the transition the CAD industry made several years ago, when companies were trying to justify the expenditure of converting to a 3D based system from a 2D based system. The advantages of using a 3D system seemed to be outweighed by the cost it would take to convert not only legacy 2D drawings into 3D models but the training of personnel to use the 3D CAD software. But the reality was that when a 3D CAD system is employed, it gives engineers a much greater ability to conceive new designs and the ability to engineer new tools and products much more effectively. Rapid Prototyping (RP) is the name given to a host of related technologies that are used to fabricate physical objects directly from Computer Aided Design (CAD) data sources. These methods are generally similar to each other in that they add and bond materials in a layer wise-fashion to form objects, instead of machining away material. The machines used in Rapid Prototyping are also sometimes referred to as Rapid Manufacturing machines due to the fact that some of the parts fabricated in a RP machine can be used as the finished product. The name "Rapid Prototyping" is really a misnomer. It is much more than prototypes and it is not always rapid.

  20. Management of large-scale technology (United States)

    Levine, A.


    Two major themes are addressed in this assessment of the management of large-scale NASA programs: (1) how a high technology agency was a decade marked by a rapid expansion of funds and manpower in the first half and almost as rapid contraction in the second; and (2) how NASA combined central planning and control with decentralized project execution.

  1. Soulful Technologies

    DEFF Research Database (Denmark)

    Fausing, Bent


    , - in short modernity - have taken away from human existence. What old technology has removed now comes back through new technology promoting a better humanity. The present article investigates how digital technology and affects are presented and combined, with examples from everyday imagery, e.g. TV...... or anthropomorphism is important for the branding of new technology. Technology is seen as creating a techno-transcendence towards a more qualified humanity which is in contact with fundamental human values like intuition, vision, and sensing; all the qualities that technology, industrialization, and rationalization......Samsung introduced in 2008 a mobile phone called "Soul" made with a human touch and including itself a "magic touch". Through the analysis of a Nokia mobile phone TV-commercials I want to examine the function and form of digital technology in everyday images. The mobile phone and its digital camera...

  2. The Multistability of Technological Breakdowns in Education

    DEFF Research Database (Denmark)

    Andersen, Bjarke Lindsø; Tafdrup, Oliver Alexander


    Introduction Everyone who is involved with modern technological artefacts such as computers, software and tablets has experienced situations where the artefacts suddenly cease to function properly. This is commonly known as a technological breakdown. Within education and the praxis of teaching...... technological breakdowns become a more and more ubiquitous phenomenon due to the rapid increase of technological artefacts utilized for educational purposes (Riis, 2012). The breakdowns impact the educational practice with consequences ranging from creating small obstacles to rendering it impossible to conduct...... successful teaching. Thus, knowing how to cope with technological breakdowns is a pivotal part of being a technological literate....

  3. Rapid precision casting for complex thin-walled aluminum alloy parts

    Directory of Open Access Journals (Sweden)

    Xuanpu DONG


    Full Text Available Based on Vacuum Differential Pressure Casting (VDPC precision forming technology and the Selective Laser Sintering (SLS Rapid Prototyping (RP technology, a rapid manufacturing method called Rapid Precision Casting (RPC process from computer three-dimensional solid models to metallic parts was investigated. The experimental results showed that the main advantage of RPC was not only its ability to cast higher internal quality and more accurate complex thin-walled aluminum alloy parts, but also the greatly-reduced lead time cycle from Selective Laser Sintering(SLS plastic prototyping to metallic parts. The key forming technology of RPC for complex thin-walled metallic parts has been developed for new casting production and Rapid Tooling (RT, and it is possible to rapidly manufacture high-quality and accurate metallic parts by means of RP in foundry industry.

  4. Metals Production Requirements for Rapid Photovoltaics Deployment

    CERN Document Server

    Kavlak, Goksin; Jaffe, Robert L; Trancik, Jessika E


    If global photovoltaics (PV) deployment grows rapidly, the required input materials need to be supplied at an increasing rate. In this paper, we quantify the effect of PV deployment levels on the scale of metals production. For example, we find that if cadmium telluride {copper indium gallium diselenide} PV accounts for more than 3% {10%} of electricity generation by 2030, the required growth rates for the production of indium and tellurium would exceed historically-observed production growth rates for a large set of metals. In contrast, even if crystalline silicon PV supplies all electricity in 2030, the required silicon production growth rate would fall within the historical range. More generally, this paper highlights possible constraints to the rate of scaling up metals production for some PV technologies, and outlines an approach to assessing projected metals growth requirements against an ensemble of past growth rates from across the metals production sector. The framework developed in this paper may be...

  5. The Social Construction of Imported Technologies: Reflections on the Social History of Technology in Modern Korea. (United States)

    Choi, Hyungsub


    Can imported technologies be socially constructed? Starting from this puzzling question, this essay reflects on the various methodologies with which one can narrate the stories of technology in modern Korea. A focus on technological innovations and how they have been shaped by their societal milieu forces one to leave out a large part of the technological experience, especially when the bulk of the technologies-in-use have been imported from abroad. This poses a serious problem for the history of technology in Korea, a nation that relied heavily on foreign technologies as it went through rapid economic growth in the latter twentieth century.

  6. Leading in a Technological Age (United States)

    Yadgir, Sheri A.


    Technology is advancing more rapidly than at any time in history since the beginning of the Industrial Revolution. In fact, experts say that the world is leaving the Industrial Age of the 20th century and entering an Information Age that will lead into the future. These advances mean that important changes are being made in all areas of life--and…

  7. Outsourcing information communication technology services

    African Journals Online (AJOL)


    The rapid technological advancement, evolution of the Internet and the availability and adoption of broadband networks has enabled even small and medium enterprises (SMEs) to implement outsourcing strategies (OECD 2008). Organizations practise outsourcing for a wide range of reasons, such as to cut costs, to bring in ...

  8. Going with the Technology Flow (United States)

    Patton, Madeline


    In the age of ubiquitous and constantly evolving technologies, decisions about what to buy, when and how to deploy digital innovations work best when community colleges use systematic, team approaches. In this article, digital education leaders of Walters State Community College (Morristown, Tennessee), Kirkwood Community College (Cedar Rapids,…

  9. A Re-Evaluation of Mobile Communication Technology: A Theoretical Approach for Technology Evaluation in Contemporary Digital Learning (United States)

    Yumurtaci, Onur


    We live in an age of continual technological development. Rapidly developing technologies have found use in nearly all aspects of life. As such, it is understandable that technology has also infiltrated the field of education. Information and Communication Technology (ICT) has provided us with the technical underpinnings for distance and lifelong…


    Relvas, Carlos; Reis, Joana; Potes, José Alberto Caeiro; Fonseca, Fernando Manuel Ferreira; Simões, José Antonio Oliveira


    This study, aimed the development of a methodology for rapid manufacture of orthopedic implants simultaneously with the surgical intervention, considering two potential applications in the fields of orthopedics: the manufacture of anatomically adapted implants and implants for bone loss replacement. This work innovation consists on the capitation of the in situ geometry of the implant by direct capture of the shape using an elastomeric material (polyvinylsiloxane) which allows fine detail and great accuracy of the geometry. After scanning the elastomeric specimen, the implant is obtained by machining using a CNC milling machine programmed with a dedicated CAD/CAM system. After sterilization, the implant is able to be placed on the patient. The concept was developed using low cost technology and commercially available. The system has been tested in an in vivo hip arthroplasty performed on a sheep. The time increase of surgery was 80 minutes being 40 minutes the time of implant manufacturing. The system developed has been tested and the goals defined of the study achieved enabling the rapid manufacture of an implant in a time period compatible with the surgery time.

  11. Rapid Glass Refiner Development Program, Final report

    Energy Technology Data Exchange (ETDEWEB)



    A rapid glass refiner (RGR) technology which could be applied to both conventional and advanced class melting systems would significantly enhance the productivity and the competitiveness of the glass industry in the United States. Therefore, Vortec Corporation, with the support of the US Department of Energy (US DOE) under Cooperative Agreement No. DE-FC07-90ID12911, conducted a research and development program for a unique and innovative approach to rapid glass refining. To provide focus for this research effort, container glass was the primary target from among the principal glass types based on its market size and potential for significant energy savings. Container glass products represent the largest segment of the total glass industry accounting for 60% of the tonnage produced and over 40% of the annual energy consumption of 232 trillion Btu/yr. Projections of energy consumption and the market penetration of advanced melting and fining into the container glass industry yield a potential energy savings of 7.9 trillion Btu/yr by the year 2020.

  12. Technological progress in ultrasonography. (United States)

    Chou, Y H


    Technical progress in ultrasonography (US) is especially rapid now, due to continuing advances in transducer design, signal processing techniques, and Doppler technology. A number of important technical breakthroughs have been made in the past decade. Among these, multidimensional array transducers, harmonic imaging, miniaturized transducers, extended field-of-view imaging, hand-carried ultrasound units, three-dimensional (3-D) US, and ultrasound contrast agents are the most remarkable innovations. Improved spatial and contrast resolution allows delineation of anatomic details and increases diagnostic accuracy and confidence. Miniaturized transducers can be used to image tiny or superficial structures in the human body, and can guide the surgeon to the problem site. Extended field-of-view imaging provides a larger field for demonstration of pathology in certain anatomic locations. Hand-carried US units are used widely in a physician's office or in remote areas, and bring high-quality medical imaging to the bedside. 3-D US has already shown significant benefits in perinatology; with further improvements in real-time imaging technology, 3-D US will emerge as an important adjunct to conventional 2-D US. In conjunction with harmonic imaging technology and Doppler technology, US contrast agents allow more powerful anatomic and functional evaluation of human organs. They may also play important therapeutic roles in the near future. Advancing computer technology is expected to lead to more important break-throughs in the next 5 to 10 years.


    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, S


    There is a need for fast, reliable methods for the determination of actinides and Sr-89/90 analysis on environmental and bioassay samples in response to an emergency radiological incident. The SRS (Savannah River Site) Environmental Bioassay Laboratory participated in the National Institute of Standards and Technology Radiochemistry Intercomparison Program (NRIP-06) and analyzed water and urine samples within 8 hours of receipt. The SRS Environmental Laboratory was the only lab that participated in the program that analyzed these samples for both actinides and Sr-89/90 within the requested 8 hour turnaround time. A new, rapid actinide and strontium 89/90 separation method was used for both urine and water samples. This method uses stacked TEVA Resin{reg_sign}, TRU Resin{reg_sign} and Sr-Resin{reg_sign} cartridges from Eichrom Technologies (Darien, IL, USA) that allows the rapid separation of plutonium (Pu), neptunium (Np), uranium (U), and americium (Am), curium (Cm) and thorium (Th) using a single multi-stage column combined with alpha spectrometry. By using vacuum box cartridge technology and stacked cartridges with rapid flow rates, sample preparation time was minimized. This paper discusses the technology and conditions employed for both water and urine samples and presents the SRS performance data on the NRIP-06 samples.

  14. Technological Frames

    Directory of Open Access Journals (Sweden)

    Karin Olesen


    Full Text Available The purpose of this article is to identify and explain the barriers that prevented the case study organization, an Australasian university, from implementing a groupware package. This is an insider action research case study, using qualitative semi-structured interviews, group and individual training to look at users’ technological frames around the implementation and use of a groupware product. Technological frames were used to enable a systematic examination of the assumptions, expectations, and knowledge of technology; in particular, the use of technological frames reveals aspects of user resistance. While addressing criticisms of the technological frames genre, this study uses technological frames as a lens to examine the underlying drivers and impediments to information systems (IS implementation. In this case study, changes to a groupware product failed to be implemented, not because of user resistance to the product, but because of organizational politics. This study demonstrates how the culture of an organization may stifle the implementation of IS.

  15. Rapid prototyping as a Tool for Designing and Manufacturing of Customised Anatomical Implants


    RM Sherekar; AN Pawar; SV Bhalerao


    Rapid prototyping (RP) technologies are mostly related with applications in the product development and the design process as well as with small batch manufacturing. Due to their comparatively high rapidity and flexibility, however, they have also been engaged in various non-manufacturing applications. A field that attracts increasingly more attention by the scientific community is related to the application of technologies in medicine and health care. The associated research is focused both ...

  16. Chemistry Technology (United States)

    Federal Laboratory Consortium — Chemistry technology experts at NCATS engage in a variety of innovative translational research activities, including:Design of bioactive small molecules.Development...

  17. A rapid two step protocol of in vitro propagation of an important ...

    African Journals Online (AJOL)

    The present investigation aimed at developing rapid micro propagation protocol, which can be used for conservation of Centella asiatica and mass multiplication of a valuable medicinal plant to meet out the pharmaceutical demand and its conservation. Attempts were made to evolve a rapid in vitro technology to conserve, ...

  18. Developmental evolution facilitates rapid adaptation. (United States)

    Lin, Hui; Kazlauskas, Romas J; Travisano, Michael


    Developmental evolution has frequently been identified as a mode for rapid adaptation, but direct observations of the selective benefits and associated mechanisms of developmental evolution are necessarily challenging to obtain. Here we show rapid evolution of greatly increased rates of dispersal by developmental changes when populations experience stringent selection. Replicate populations of the filamentous fungus Trichoderma citrinoviride underwent 85 serial transfers, under conditions initially favoring growth but not dispersal. T. citrinoviride populations shifted away from multicellular growth toward increased dispersal by producing one thousand times more single-celled asexual conidial spores, three times sooner than the ancestral genotype. Conidia of selected lines also germinated fifty percent faster. Gene expression changed substantially between the ancestral and selected fungi, especially for spore production and growth, demonstrating rapid evolution of tight regulatory control for down-regulation of growth and up-regulation of conidia production between 18 and 24 hours of growth. These changes involved both developmentally fixed and plastic changes in gene expression, showing that complex developmental changes can serve as a mechanism for rapid adaptation.

  19. Multigrade Teaching Rapid Appraisal Procedure. (United States)

    Nielsen, Dean

    Multigrade classes have been recognized as part of elementary education for many years, but their special needs have been largely ignored. This manual focuses on the survey research that should predate the design of instructional management strategies in multigrade classrooms. It describes rapid and reliable ways to collect information about the…

  20. Rapid thermal processing of semiconductors

    CERN Document Server

    Borisenko, Victor E


    Rapid thermal processing has contributed to the development of single wafer cluster processing tools and other innovations in integrated circuit manufacturing environments Borisenko and Hesketh review theoretical and experimental progress in the field, discussing a wide range of materials, processes, and conditions They thoroughly cover the work of international investigators in the field

  1. Furnace for rapid thermal processing

    NARCIS (Netherlands)

    Roozeboom, F.; Duine, P.A.; Sluis, P. van der


    A Method (1) for Rapid Thermal Processing of a wafer (7), wherein the wafer (7) is heated by lamps (9), and the heat radiation is reflected by an optical switching device (15,17) which is in the reflecting state during the heating stage. During the cooling stage of the wafer (7), the heat is

  2. Rapid Energy Modeling Workflow Demonstration (United States)


    BIM Building Information Modeling BPA Building Performance Analysis BTU British Thermal Unit CBECS Commercial Building ...geometry, orientation, weather, and materials, generates 3D Building Information Models ( BIM ) guided by satellite views of building footprints and...Rapid Energy Modeling (REM) workflows that employed building information modeling ( BIM ) approaches and conceptual energy analysis.

  3. Portable Diagnostics and Rapid Germination

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Zachary Spencer [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    In the Bioenergy and Defense Department of Sandia National Laboratories, characterization of the BaDx (Bacillus anthracis diagnostic cartridge) was performed and rapid germination chemistry was investigated. BaDx was tested with complex sample matrixes inoculated with Bacillus anthracis, and the trials proved that BaDx will detect Bacillus anthracis in a variety of the medium, such as dirt, serum, blood, milk, and horse fluids. The dimensions of the device were altered to accommodate an E. coli or Listeria lateral flow immunoassay, and using a laser printer, BaDx devices were manufactured to identify E. coli and Listeria. Initial testing with E. coli versions of BaDx indicate that the device will be viable as a portable diagnostic cartridge. The device would be more effective with faster bacteria germination; hence studies were performed the use of rapid germination chemistry. Trials with calcium dipicolinic acid displayed increased cell germination, as shown by control studies using a microplate reader. Upon lyophilization the rapid germination chemistry failed to change growth patterns, indicating that the calcium dipicolinic acid was not solubilized under the conditions tested. Although incompatible with the portable diagnostic device, the experiments proved that the rapid germination chemistry was effective in increasing cell germination.

  4. RSP Tooling Technology

    Energy Technology Data Exchange (ETDEWEB)



    RSP Tooling{trademark} is a spray forming technology tailored for producing molds and dies. The approach combines rapid solidification processing and net-shape materials processing in a single step. The general concept involves converting a mold design described by a CAD file to a tooling master using a suitable rapid prototyping (RP) technology such as stereolithography. A pattern transfer is made to a castable ceramic, typically alumina or fused silica (Figure 1). This is followed by spray forming a thick deposit of a tooling alloy on the pattern to capture the desired shape, surface texture, and detail. The resultant metal block is cooled to room temperature and separated from the pattern. The deposit's exterior walls are machined square, allowing it to be used as an insert in a standard mold base. The overall turnaround time for tooling is about 3 to 5 days, starting with a master. Molds and dies produced in this way have been used in high volume production runs in plastic injection molding and die casting. A Cooperative Research and Development Agreement (CRADA) between the Idaho National Engineering and Environmental Laboratory (INEEL) and Grupo Vitro has been established to evaluate the feasibility of using RSP Tooling technology for producing molds and dies of interest to Vitro. This report summarizes results from Phase I of this agreement, and describes work scope and budget for Phase I1 activities. The main objective in Phase I was to demonstrate the feasibility of applying the Rapid Solidification Process (RSP) Tooling method to produce molds for the manufacture of glass and other components of interest to Vitro. This objective was successfully achieved.

  5. Ceramic Technology Project

    Energy Technology Data Exchange (ETDEWEB)


    The Ceramic Technology Project was developed by the USDOE Office of Transportation Systems (OTS) in Conservation and Renewable Energy. This project, part of the OTS's Materials Development Program, was developed to meet the ceramic technology requirements of the OTS's automotive technology programs. Significant accomplishments in fabricating ceramic components for the USDOE and NASA advanced heat engine programs have provided evidence that the operation of ceramic parts in high-temperature engine environments is feasible. These programs have also demonstrated that additional research is needed in materials and processing development, design methodology, and data base and life prediction before industry will have a sufficient technology base from which to produce reliable cost-effective ceramic engine components commercially. A five-year project plan was developed with extensive input from private industry. In July 1990 the original plan was updated through the estimated completion of development in 1993. The objective is to develop the industrial technology base required for reliable ceramics for application in advanced automotive heat engines. The project approach includes determining the mechanisms controlling reliability, improving processes for fabricating existing ceramics, developing new materials with increased reliability, and testing these materials in simulated engine environments to confirm reliability. Although this is a generic materials project, the focus is on the structural ceramics for advanced gas turbine and diesel engines, ceramic bearings and attachments, and ceramic coatings for thermal barrier and wear applications in these engines. To facilitate the rapid transfer of this technology to US industry, the major portion of the work is being done in the ceramic industry, with technological support from government laboratories, other industrial laboratories, and universities.

  6. Rapid prototyping and stereolithography in dentistry. (United States)

    Nayar, Sanjna; Bhuminathan, S; Bhat, Wasim Manzoor


    The word rapid prototyping (RP) was first used in mechanical engineering field in the early 1980s to describe the act of producing a prototype, a unique product, the first product, or a reference model. In the past, prototypes were handmade by sculpting or casting, and their fabrication demanded a long time. Any and every prototype should undergo evaluation, correction of defects, and approval before the beginning of its mass or large scale production. Prototypes may also be used for specific or restricted purposes, in which case they are usually called a preseries model. With the development of information technology, three-dimensional models can be devised and built based on virtual prototypes. Computers can now be used to create accurately detailed projects that can be assessed from different perspectives in a process known as computer aided design (CAD). To materialize virtual objects using CAD, a computer aided manufacture (CAM) process has been developed. To transform a virtual file into a real object, CAM operates using a machine connected to a computer, similar to a printer or peripheral device. In 1987, Brix and Lambrecht used, for the first time, a prototype in health care. It was a three-dimensional model manufactured using a computer numerical control device, a type of machine that was the predecessor of RP. In 1991, human anatomy models produced with a technology called stereolithography were first used in a maxillofacial surgery clinic in Viena.

  7. Rapid prototyping and stereolithography in dentistry

    Directory of Open Access Journals (Sweden)

    Sanjna Nayar


    Full Text Available The word rapid prototyping (RP was first used in mechanical engineering field in the early 1980s to describe the act of producing a prototype, a unique product, the first product, or a reference model. In the past, prototypes were handmade by sculpting or casting, and their fabrication demanded a long time. Any and every prototype should undergo evaluation, correction of defects, and approval before the beginning of its mass or large scale production. Prototypes may also be used for specific or restricted purposes, in which case they are usually called a preseries model. With the development of information technology, three-dimensional models can be devised and built based on virtual prototypes. Computers can now be used to create accurately detailed projects that can be assessed from different perspectives in a process known as computer aided design (CAD. To materialize virtual objects using CAD, a computer aided manufacture (CAM process has been developed. To transform a virtual file into a real object, CAM operates using a machine connected to a computer, similar to a printer or peripheral device. In 1987, Brix and Lambrecht used, for the first time, a prototype in health care. It was a three-dimensional model manufactured using a computer numerical control device, a type of machine that was the predecessor of RP. In 1991, human anatomy models produced with a technology called stereolithography were first used in a maxillofacial surgery clinic in Viena.

  8. Information and communication technology and bank performance ...

    African Journals Online (AJOL)

    Different sectors of world economies are rapidly being affected by improved technology. Banking sector is also witnessing the trend in Nigeria. Information and communication Technology is said to have impacted the banking sector massively as the banks in Nigeria introduce products that would help improve their efficiency ...

  9. Virtual Education: Guidelines for Using Games Technology (United States)

    Schofield, Damian


    Advanced three-dimensional virtual environment technology, similar to that used by the film and computer games industry, can allow educational developers to rapidly create realistic online virtual environments. This technology has been used to generate a range of interactive Virtual Reality (VR) learning environments across a spectrum of…

  10. New Technology "Clouds" Student Data Privacy (United States)

    Krueger, Keith R.; Moore, Bob


    As technology has leaped forward to provide valuable learning tools, parents and policy makers have begun raising concerns about the privacy of student data that schools and systems have. Federal laws are intended to protect students and their families but they have not and will never be able to keep up with rapidly evolving technology. School…

  11. Mobile technology: streamlining practice and improving care


    Blake, Holly


    The use of mobile phones in care delivery has the potential to improve the way in which care is delivered. When implemented effectively, mobile technologies can empower patients and enhance communication between patients and their health-care providers. When barriers are recognised and addressed, mobile technologies can change working lives, facilitating rapid access to information and supporting efficiency in practice.

  12. Thermally activated technologies: Technology Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    None, None


    The purpose of this Technology Roadmap is to outline a set of actions for government and industry to develop thermally activated technologies for converting America’s wasted heat resources into a reservoir of pollution-free energy for electric power, heating, cooling, refrigeration, and humidity control. Fuel flexibility is important. The actions also cover thermally activated technologies that use fossil fuels, biomass, and ultimately hydrogen, along with waste heat.

  13. Maritime Technology

    DEFF Research Database (Denmark)

    Sørensen, Herman


    Elementary introduction to the subject "Maritime Technology".The contents include drawings, sketches and references in English without any supplementary text.......Elementary introduction to the subject "Maritime Technology".The contents include drawings, sketches and references in English without any supplementary text....

  14. Lasers technology

    Energy Technology Data Exchange (ETDEWEB)



    The Lasers Technology Program of IPEN is committed to the development of new lasers based on the research of optical materials and new technologies, as well to laser applications in several areas: Nuclear, Medicine, Dentistry, Industry, Environment and Advanced Research. The Program is basically divided into two main areas: Material and Laser Development and Laser Applications.

  15. Technology assessment

    NARCIS (Netherlands)

    Rip, Arie; Wright, James D.


    Technology assessment (TA) refers to the early identification and assessment of eventual impacts of technological change and applications, as a service to policy making and decision making more generally. TA can be done by (or for) business firms, or as a medical, social, or environmental impact

  16. Technological Advancements (United States)

    Kennedy, Mike


    The influx of technology has brought significant improvements to school facilities. Many of those advancements can be found in classrooms, but when students head down the hall to use the washrooms, they are likely to find a host of technological innovations that have improved conditions in that part of the building. This article describes modern…

  17. Technology collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Jacob [Halliburton (Brazil)


    The aim of this paper is to present Halliburton's Brazilian technology center. Halliburton has technology centers in the United States, Saudi Arabia, India, Singapore and Brazil, all of which aim at delivering accelerated innovation in the oil sector. The technology centers engage in research and development activities with the help of various universities and in collaboration with the customer or supplier. The Halliburton Brazil technology center provides its customers with timely research and development solutions for enhancing recovery and mitigating reservoir uncertainty; they are specialized in finding solutions for pre- and post-salt carbonate drilling and in the enhancement of production from mature fields. This presentation showcased the work carried out by the Halliburton Brazil technology center to help customers develop their deepwater field activities.

  18. Sensemaking technology

    DEFF Research Database (Denmark)

    Madsen, Charlotte Øland

    Research objective: The object of the LOK research project is to gain a better understanding of the technological strategic processes in organisations by using the concept/metaphor of sensemaking. The project will investigate the technological strategies in organisations in order to gain a deeper...... understanding of the cognitive competencies and barriers towards implementing new technology in organisations. The research will therefore concentrate on researching the development process in the organisation's perception of the external environmental elements of customers, suppliers, competitors, internal...... and external technology and legislation and the internal environmental elements of structure, power relations and political arenas. All of these variables have influence on which/how technologies are implemented thus creating different outcomes all depending on the social dynamics that are triggered by changes...

  19. Choosing the right technology

    DEFF Research Database (Denmark)

    Milan, Christian; Nielsen, Mads Pagh; Bojesen, Carsten


    the planning process. The methodology allows for specifying a level of Net Zero Energy Building (Net ZEB) performance to investigate cost reductions when allowing shares of fossil fuel consumption. The outcome is an optimal supply technology combination and optimal installed capacities in terms of the overall...... costs including system installation and operating expenses. The approach is applied to a case study of a residential single family house under Danish conditions. It delivers rapidly site-specific solutions and can easily be used as an extension for common building energy simulation software. In the case....... These systems not only require an optimal design with respect to the installed capacities but also the right choice in combining the available technologies assuring a cost-effective solution. e aim of this paper is to present an optimization methodology for residential on-site energy supply systems based...

  20. Technological solutions for encapsulation (United States)

    Trojanowska, Anna; Nogalska, Adrianna; Valls, Ricard Garcia; Giamberini, Marta; Tylkowski, Bartosz


    Encapsulation offers broad scope of applications. It can be used to deliver almost everything from advanced drugs to unique consumer sensory experiences; it could be also employed as a protection system or a sensing material. This cutting-edge technology undergoes rapid growth in both academic and industrial conditions. Research in this matter is continuing to find a new application of microcapsules as well as to improve the methods of their fabrication. Therefore, in this review, we focus on the art of the encapsulation technology to provide the readers with a comprehensive and in-depth understanding of up-to-day development of microcapsule preparation methods. Our goal is to help identify the major encapsulation processes and by doing so maximize the potential value of ongoing research efforts.

  1. Technology Roadmaps: Nuclear Energy

    Energy Technology Data Exchange (ETDEWEB)



    This nuclear energy roadmap has been prepared jointly by the IEA and the OECD Nuclear Energy Agency (NEA). Unlike most other low-carbon energy sources, nuclear energy is a mature technology that has been in use for more than 50 years. The latest designs for nuclear power plants build on this experience to offer enhanced safety and performance, and are ready for wider deployment over the next few years. Several countries are reactivating dormant nuclear programmes, while others are considering nuclear for the first time. China in particular is already embarking on a rapid nuclear expansion. In the longer term, there is great potential for new developments in nuclear energy technology to enhance nuclear's role in a sustainable energy future.

  2. Rapid detection of genetic modification for GMO monitoring in agriculture

    Directory of Open Access Journals (Sweden)

    Petrović Sofija


    Full Text Available Transgenic technology has expanded the ways of new genetic variability creation. Genetically modified organisms (GMOs are organisms which total genome is altered in a way that could not happen in nature. GM crops recorded a steady increase in its share in agricultural production. However, for the most part, GMO in agriculture has been limited to two cultivars - soy and corn, and the two genetic modifications, the total herbicide resistance and pest of the Lepidoptera genus. In order to monitor cultivation and trade of GMOs, tests of different precision are used, qualitatively and/or quantitatively determining the presence of genetic modification. Tests for the rapid determination of the presence of GM are suitable, since they can be implemented quickly and accurately, in terms of declared sensitivity, outside or in the laboratory. The example of the use of rapid tests demonstrates their value in use for rapid and efficient monitoring.

  3. Rapidly solidified Mg-Al-Zn-rare earth alloys

    Energy Technology Data Exchange (ETDEWEB)

    Chang, C.F.; Das, S.K.; Raybould, D.


    Among the light metal alloys, magnesium is the lightest structural material except for beryllium, and yet magnesium alloys have not seen extensive use because of their poor strength and corrosion resistance. Rapid solidification technology offers a possible solution to these problems. A number of Mg-Al-Zn alloys containing rare earth (RE) elements (e.g. Ce, Pr, Y, and Nd) have been investigated using rapid solidification processing for possible structural applications. The processing consists of planar flow or jet casting into ribbons, pulverization of ribbon to powder, and consolidation of powder into bulk shapes. The mechanical properties of some of these alloys show attractive combinations of strength, ductility and corrosion resistance. The microstructures of these alloys are correlated with their mechanical properties. The rapidly solidified Mg-Al-Zn-RE alloys show great potential for applications in automotive and aerospace industries. 7 references.


    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, S.; Culligan, B.


    A new rapid separation method for radiostrontium in emergency milk samples was developed at the Savannah River Site (SRS) Environmental Bioassay Laboratory (Aiken, SC, USA) that will allow rapid separation and measurement of Sr-90 within 8 hours. The new method uses calcium phosphate precipitation, nitric acid dissolution of the precipitate to coagulate residual fat/proteins and a rapid strontium separation using Sr Resin (Eichrom Technologies, Darien, IL, USA) with vacuum-assisted flow rates. The method is much faster than previous method that use calcination or cation exchange pretreatment, has excellent chemical recovery, and effectively removes beta interferences. When a 100 ml sample aliquot is used, the method has a detection limit of 0.5 Bq/L, well below generic emergency action levels.

  5. Rapid Conditioning for the Next Generation Melting System

    Energy Technology Data Exchange (ETDEWEB)

    Rue, David M. [Gas Technology Institute, Des Plaines, IL (United States)


    This report describes work on Rapid Conditioning for the Next Generation Melting System under US Department of Energy Contract DE-FC36-06GO16010. The project lead was the Gas Technology Institute (GTI). Partners included Owens Corning and Johns Manville. Cost share for this project was provided by NYSERDA (the New York State Energy Research and Development Authority), Owens Corning, Johns Manville, Owens Illinois, and the US natural gas industry through GTI’s SMP and UTD programs. The overreaching focus of this project was to study and develop rapid refining approaches for segmented glass manufacturing processes using high-intensity melters such as the submerged combustion melter. The objectives of this project were to 1) test and evaluate the most promising approaches to rapidly condition the homogeneous glass produced from the submerged combustion melter, and 2) to design a pilot-scale NGMS system for fiberglass recycle.





    Health care facilities, whether in developed or developing countries, are increasingly finding themselves carrying out a balancing act between the available financial resources and demand for rapidly changing medical technology. The current situation on management of medical technology, especially sophisticated medical equipment, in India and developed countries is discussed and managerial methods suggested to make technology more need-based than demand-based. Lack of standardization of medic...

  7. A new software behavior extraction technology (United States)

    Long, Ke; Xu, Haishui


    Symbolic execution is a program analysis technology put forward in 70s and draws more and more attention in recent years. It is mainly used in field of software test, which is used to discover errors in the program and potential vulnerabilities automatically and efficiently[. With the rapid progress of the related technology, its potential applications in academia and industry is higher and higher. In this paper, the technology is used to obtain training data of drivers execution.

  8. Low temperature plasma technology methods and applications

    CERN Document Server

    Chu, Paul K


    Written by a team of pioneering scientists from around the world, Low Temperature Plasma Technology: Methods and Applications brings together recent technological advances and research in the rapidly growing field of low temperature plasmas. The book provides a comprehensive overview of related phenomena such as plasma bullets, plasma penetration into biofilms, discharge-mode transition of atmospheric pressure plasmas, and self-organization of microdischarges. It describes relevant technology and diagnostics, including nanosecond pulsed discharge, cavity ringdown spectroscopy, and laser-induce

  9. Rapid scenarios and observed intensities


    Franco Pettenati; Livio Sirovich


    After a destructive earthquake, national Governments need to know the approximate amount of damage, the number of casualties, and the financial losses as soon as possible. Rapid scenarios are also used to inform the general public; see the widely used Shakemap package [Wald et al. 1999, 2006] of the US Geological Survey (USGS) and the one modified by the Istituto Nazionale di Geofisica e Vulcanologia (INGV; National Institute of Geophysics and Volcanology), which is reproduced for Figure 1. T...

  10. Rapid synthesis of beta zeolites (United States)

    Fan, Wei; Chang, Chun -Chih; Dornath, Paul; Wang, Zhuopeng


    The invention provides methods for rapidly synthesizing heteroatom containing zeolites including Sn-Beta, Si-Beta, Ti-Beta, Zr-Beta and Fe-Beta. The methods for synthesizing heteroatom zeolites include using well-crystalline zeolite crystals as seeds and using a fluoride-free, caustic medium in a seeded dry-gel conversion method. The Beta zeolite catalysts made by the methods of the invention catalyze both isomerization and dehydration reactions.

  11. Rapid Detection, Characterization, and Enumeration of Foodborne Pathogens

    DEFF Research Database (Denmark)

    This book provides a new focus on the rapid detection of food–borne pathogens, employing food production chains as a starting point instead of a specific method or various detection technologies. This reference is organized by production chains or contamination scenarios, and offers a unique...... in implementation. It also provides guidelines for faster, more user–friendly, and cost–effective enumeration of pathogens....

  12. Rapid scenarios and observed intensities

    Directory of Open Access Journals (Sweden)

    Franco Pettenati


    Full Text Available After a destructive earthquake, national Governments need to know the approximate amount of damage, the number of casualties, and the financial losses as soon as possible. Rapid scenarios are also used to inform the general public; see the widely used Shakemap package [Wald et al. 1999, 2006] of the US Geological Survey (USGS and the one modified by the Istituto Nazionale di Geofisica e Vulcanologia (INGV; National Institute of Geophysics and Volcanology, which is reproduced for Figure 1. The general matter of the use of intensities in damage scenarios was discussed in a special session at the 2008 Annual Meeting of the Seismological Society of America (, and was also discussed in the NIS-1 session of the European Congress in Moscow, in August 2012 ( The purposes of the present report are to: (i compare different types of intensities; (ii check two rapid scenarios of intensity; and (iii understand whether the KF formula [Sirovich 1996, Sirovich et al. 2009] can be used as a new 'attenuation' relationship to improve rapid scenarios. […

  13. Rapid diagnosis of mycobacterial infections

    Directory of Open Access Journals (Sweden)

    Michel Drancourt


    Full Text Available While pulmonary tuberculosis (PTB remains an important public health issue worldwide, there is an emerging interest in non-tuberculous mycobacteria (NTM which is responsible for opportunistic infections of the respiratory tract as well as other anatomical sites in both developed and developing countries. In this context the one goal of the clinical mycobacteriology laboratories is to provide physicians with an accurate identification of the mycobacterium as rapidly as possible. During the last ten years, several lines of laboratory tools have been developed in order to speed the isolation and identification of mycobacteria from clinical specimens. Chiefly, the composition of culture medium was renewed along with the protocol of incubation in order to recover Mycobacterium tuberculosis (MTB micro-colonies as soon as 48 h after the inoculation of the specimen. MALDI-TOF rapid identification is clearly the tool to be implemented in the laboratory for the rapid identification of the micro-colonies. Also, molecular tools and genomics are necessary in order to depict new mycobacteria species, including those of the Mycobacterium abscessus complex and the Mycobacterium avium complex. All these tools and their connections will be presented during this conference.

  14. Ergonomics technology (United States)

    Jones, W. L.


    Major areas of research and development in ergonomics technology for space environments are discussed. Attention is given to possible applications of the technology developed by NASA in industrial settings. A group of mass spectrometers for gas analysis capable of fully automatic operation has been developed for atmosphere control on spacecraft; a version for industrial use has been constructed. Advances have been made in personal cooling technology, remote monitoring of medical information, and aerosol particle control. Experience gained by NASA during the design and development of portable life support units has recently been applied to improve breathing equipment used by fire fighters.


    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, S.; Culligan, B.; Noyes, G.


    A new rapid method for the determination of actinides in soil and sediment samples has been developed at the Savannah River Site Environmental Lab (Aiken, SC, USA) that can be used for samples up to 2 grams in emergency response situations. The actinides in soil method utilizes a rapid sodium hydroxide fusion method, a lanthanum fluoride soil matrix removal step, and a streamlined column separation process with stacked TEVA, TRU and DGA Resin cartridges. Lanthanum was separated rapidly and effectively from Am and Cm on DGA Resin. Vacuum box technology and rapid flow rates are used to reduce analytical time. Alpha sources are prepared using cerium fluoride microprecipitation for counting by alpha spectrometry. The method showed high chemical recoveries and effective removal of interferences. This new procedure was applied to emergency soil samples received in the NRIP Emergency Response exercise administered by the National Institute for Standards and Technology (NIST) in April, 2009. The actinides in soil results were reported within 4-5 hours with excellent quality.

  16. Videodisc technology

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, F.E. Jr.


    An overview of the technology of videodiscs is given. The emphasis is on systems that use reflection or transmission of laser light. Possible use of videodiscs for storage of bibliographic information is considered. 6 figures, 3 tables. (RWR)

  17. Technology Innovation (United States)

    EPA produces innovative technologies and facilitates their creation in line with the Agency mission to create products such as the stormwater calculator, remote sensing, innovation clusters, and low-cost air sensors.

  18. Technology | FNLCR (United States)

    The Frederick National Laboratory develops and applies advanced, next-generation technologies to solve basic and applied problems in the biomedical sciences, and serves as a national resource of shared high-tech facilities.


    National Research Council Canada - National Science Library

    Thomas K Grose


      Inspired by Star Trek turbolifts, German engineering firm ThyssenKrupp says it's ready to replace cables and pulleys using maglev, or magnetic levitation technology, that enables the world's fastest...

  20. Banana technology (United States)

    van Amstel, Willem D.; Schellekens, E. P. A.; Walravens, C.; Wijlaars, A. P. F.


    With 'Banana Technology' an unconventional hybrid fabrication technology is indicated for the production of very large parabolic and hyperbolic cylindrical mirror systems. The banana technology uses elastic bending of very large and thin glass substrates and fixation onto NC milled metal moulds. This technology has matured during the last twenty years for the manufacturing of large telecentric flat-bed scanners. Two construction types, called 'internal banana' and 'external banana; are presented. Optical figure quality requirements in terms of slope and curvature deviations are discussed. Measurements of these optical specifications by means of a 'finishing rod' type of scanning deflectometer or slope tester are presented. Design constraints for bending glass and the advantages of a new process will be discussed.

  1. Exploration technology

    Energy Technology Data Exchange (ETDEWEB)

    Roennevik, H.C. [Saga Petroleum A/S, Forus (Norway)


    The paper evaluates exploration technology. Topics discussed are: Visions; the subsurface challenge; the creative tension; the exploration process; seismic; geology; organic geochemistry; seismic resolution; integration; drilling; value creation. 4 refs., 22 figs.

  2. Advanced Mirror & Modelling Technology Development (United States)

    Effinger, Michael; Stahl, H. Philip; Abplanalp, Laura; Maffett, Steven; Egerman, Robert; Eng, Ron; Arnold, William; Mosier, Gary; Blaurock, Carl


    The 2020 Decadal technology survey is starting in 2018. Technology on the shelf at that time will help guide selection to future low risk and low cost missions. The Advanced Mirror Technology Development (AMTD) team has identified development priorities based on science goals and engineering requirements for Ultraviolet Optical near-Infrared (UVOIR) missions in order to contribute to the selection process. One key development identified was lightweight mirror fabrication and testing. A monolithic, stacked, deep core mirror was fused and replicated twice to achieve the desired radius of curvature. It was subsequently successfully polished and tested. A recently awarded second phase to the AMTD project will develop larger mirrors to demonstrate the lateral scaling of the deep core mirror technology. Another key development was rapid modeling for the mirror. One model focused on generating optical and structural model results in minutes instead of months. Many variables could be accounted for regarding the core, face plate and back structure details. A portion of a spacecraft model was also developed. The spacecraft model incorporated direct integration to transform optical path difference to Point Spread Function (PSF) and between PSF to modulation transfer function. The second phase to the project will take the results of the rapid mirror modeler and integrate them into the rapid spacecraft modeler.

  3. Cognitive technologies

    CERN Document Server

    Mello, Alan; Figueiredo, Fabrício; Figueiredo, Rafael


    This book focuses on the next generation optical networks as well as mobile communication technologies. The reader will find chapters on Cognitive Optical Network, 5G Cognitive Wireless, LTE, Data Analysis and Natural Language Processing. It also presents a comprehensive view of the enhancements and requirements foreseen for Machine Type Communication. Moreover, some data analysis techniques and Brazilian Portuguese natural language processing technologies are also described here. .

  4. Lasers technology

    Energy Technology Data Exchange (ETDEWEB)



    The Laser Technology Program of IPEN is developed by the Center for Lasers and Applications (CLA) and is committed to the development of new lasers based on the research of new optical materials and new resonator technologies. Laser applications and research occur within several areas such as Nuclear, Medicine, Dentistry, Industry, Environment and Advanced Research. Additional goals of the Program are human resource development and innovation, in association with Brazilian Universities and commercial partners.

  5. Inside the black box: technology and economics

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, N.


    The author shows how specific features of individual technologies have shaped a number of variables of concern to economists: the rate of productivity improvement, the nature of the learning process underlying technological change itself, the speed of technology transfer, and the effectiveness of government policies that are intended to influence technologies in particular ways. The separate chapters reflect a primary concern with some of the distinctive aspects of industrial technologies in the 20th Century, such as the increasing reliance upon science, but also the considerable subtlety and complexity of the dialectic between science and technology. Other concerns include the rapid growth in the development cost associated with new technologies as well as the difficulty of predicting the eventual performance characteristics of newly emerging technologies. 447 footnotes and references, 4 figures, 11 tables

  6. Regulatory and Permitting Information Desktop (RAPID) Toolkit (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Young, K. R.; Levine, A.


    The Regulatory and Permitting Information Desktop (RAPID) Toolkit combines the former Geothermal Regulatory Roadmap, National Environmental Policy Act (NEPA) Database, and other resources into a Web-based tool that gives the regulatory and utility-scale geothermal developer communities rapid and easy access to permitting information. RAPID currently comprises five tools - Permitting Atlas, Regulatory Roadmap, Resource Library, NEPA Database, and Best Practices. A beta release of an additional tool, the Permitting Wizard, is scheduled for late 2014. Because of the huge amount of information involved, RAPID was developed in a wiki platform to allow industry and regulatory agencies to maintain the content in the future so that it continues to provide relevant and accurate information to users. In 2014, the content was expanded to include regulatory requirements for utility-scale solar and bulk transmission development projects. Going forward, development of the RAPID Toolkit will focus on expanding the capabilities of current tools, developing additional tools, including additional technologies, and continuing to increase stakeholder involvement.

  7. Rapid determination of radiostrontium in seawater samples

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, Sherrod L.; Culligan, Brian K.; Utsey, Robin C.


    A new method for the determination of radiostrontium in seawater samples has been developed at the Savannah River National Laboratory (SRNL) that allows rapid preconcentration and separation of strontium and yttrium isotopes in seawater samples for measurement. The new SRNL method employs a novel and effective pre-concentration step that utilizes a blend of calcium phosphate with iron hydroxide to collect both strontium and yttrium rapidly from the seawater matrix with enhanced chemical yields. The pre-concentration steps, in combination with rapid Sr Resin and DGA Resin cartridge separation options using vacuum box technology, allow seawater samples up to 10 liters to be analyzed. The total 89Sr + 90Sr activity may be determined by gas flow proportional counting and recounted after ingrowth of 90Y to differentiate 89Sr from 90Sr. Gas flow proportional counting provides a lower method detection limit than liquid scintillation or Cerenkov counting and allows simultaneous counting of samples. Simultaneous counting allows for longer count times and lower method detection limits without handling very large aliquots of seawater. Seawater samples up to 6 liters may be analyzed using Sr Resin for 89Sr and 90Sr with a Minimum Detectable Activity (MDA) of 1-10 mBq/L, depending on count times. Seawater samples up to 10 liters may be analyzed for 90Sr using a DGA Resin method via collection and purification of 90Y only. If 89Sr and other fission products are present, then 91Y (beta energy 1.55 MeV, 58.5 day half-life) is also likely to be present. 91Y interferes with attempts to collect 90Y directly from the seawater sample without initial purification of Sr isotopes first and 90Y ingrowth. The DGA Resin option can be used to determine 90Sr, and if 91Y is also present, an ingrowth option with using DGA

  8. Technology cycles and technology revolutions

    Energy Technology Data Exchange (ETDEWEB)

    Paganetto, Luigi; Scandizzo, Pasquale Lucio


    Technological cycles have been characterized as the basis of long and continuous periods economic growth through sustained changes in total factor productivity. While this hypothesis is in part consistent with several theories of growth, the sheer magnitude and length of the economic revolutions experienced by humankind seems to indicate surmise that more attention should be given to the origin of major technological and economic changes, with reference to one crucial question: role of production and use of energy in economic development.

  9. New-generation radiofrequency technology. (United States)

    Krueger, Nils; Sadick, Neil S


    Radiofrequency (RF) technology has become a standard treatment in aesthetic medicine with many indications due to its versatility, efficacy, and safety. It is used worldwide for cellulite reduction; acne scar revision; and treatment of hypertrophic scars and keloids, rosacea, and inflammatory acne in all skin types. However, the most common indication for RF technology is the nonablative tightening of tissue to improve skin laxity and reduce wrinkles. Radiofrequency devices are classified as unipolar, bipolar, or multipolar depending on the number of electrodes used. Additional modalities include fractional RF; sublative RF; phase-controlled RF; and combination RF therapies that apply light, massage, or pulsed electromagnetic fields (PEMFs). This article reviews studies and case series on these devices. Radiofrequency technology for aesthetic medicine has seen rapid advancements since it was used for skin tightening in 2003. Future developments will continue to keep RF technology at the forefront of the dermatologist's armamentarium for skin tightening and rejuvenation.

  10. Developing Indicators for a Classroom Observation Tool on Pedagogy and Technology Integration: A Delphi Study (United States)

    Elmendorf, Douglas C.; Song, Liyan


    Rapid advances in technology and increased access to technology tools have created new instructional demands and expectations on teachers. Due to the ubiquitous presence of technology in K-12 schools, teachers are being observed on both their pedagogical and technology integration practices. Applying the technological pedagogical and content…

  11. Oral strip technology: overview and future potential. (United States)

    Dixit, R P; Puthli, S P


    Over the recent past, many of the research groups are focusing their research on this technology. Amongst the plethora of avenues explored for rapid drug releasing products, Oral Strip Technology (OST) is gaining much attention. The advantages of OST are the administration to pediatric and geriatric patient population where the difficulty of swallowing larger oral dosage forms is eliminated. This technology has been used for local action, rapid release products and for buccoadhesive systems that are retained for longer period in the oral cavity to release drug in controlled fashion. OST offers an alternate platform for molecules that undergo first pass metabolism and for delivery of peptides. The review article is an overview of OST encompassing materials used in OST, critical manufacturing aspects, applications, commercial technologies and future business prospects of this technology.

  12. Wyoming Basin Rapid Ecoregional Assessment (United States)

    Carr, Natasha B.; Melcher, Cynthia P.


    The Wyoming Basin Rapid Ecoregional Assessment was conducted in partnership with the Bureau of Land Management (BLM). The overall goals of the BLM Rapid Ecoregional Assessments (REAs) are to identify important ecosystems and wildlife habitats at broad spatial scales; identify where these resources are at risk from Change Agents, including development, wildfire, invasive species, disease and climate change; quantify cumulative effects of anthropogenic stressors; and assess current levels of risk to ecological resources across a range of spatial scales and jurisdictional boundaries by assessing all lands within an ecoregion. There are several components of the REAs. Management Questions, developed by the BLM and stakeholders for the ecoregion, identify the regionally significant information needed for addressing land-management responsibilities. Conservation Elements represent regionally significant species and ecological communities that are of management concern. Change Agents that currently affect or are likely to affect the condition of species and communities in the future are identified and assessed. REAs also identify areas that have high conservation potential that are referred to as “large intact areas.” At the ecoregion level, the ecological value of large intact areas is based on the assumption that because these areas have not been greatly altered by human activities (such as development), they are more likely to contain a variety of plant and animal communities and to be resilient and resistant to changes resulting from natural disturbances such as fire, insect outbreaks, and disease.

  13. Rapid self-healing hydrogels (United States)

    Phadke, Ameya; Zhang, Chao; Arman, Bedri; Hsu, Cheng-Chih; Mashelkar, Raghunath A.; Lele, Ashish K.; Tauber, Michael J.; Arya, Gaurav; Varghese, Shyni


    Synthetic materials that are capable of autonomous healing upon damage are being developed at a rapid pace because of their many potential applications. Despite these advancements, achieving self-healing in permanently cross-linked hydrogels has remained elusive because of the presence of water and irreversible cross-links. Here, we demonstrate that permanently cross-linked hydrogels can be engineered to exhibit self-healing in an aqueous environment. We achieve this feature by arming the hydrogel network with flexible-pendant side chains carrying an optimal balance of hydrophilic and hydrophobic moieties that allows the side chains to mediate hydrogen bonds across the hydrogel interfaces with minimal steric hindrance and hydrophobic collapse. The self-healing reported here is rapid, occurring within seconds of the insertion of a crack into the hydrogel or juxtaposition of two separate hydrogel pieces. The healing is reversible and can be switched on and off via changes in pH, allowing external control over the healing process. Moreover, the hydrogels can sustain multiple cycles of healing and separation without compromising their mechanical properties and healing kinetics. Beyond revealing how secondary interactions could be harnessed to introduce new functions to chemically cross-linked polymeric systems, we also demonstrate various potential applications of such easy-to-synthesize, smart, self-healing hydrogels. PMID:22392977

  14. Rapid generalization in phonotactic learning

    Directory of Open Access Journals (Sweden)

    Tal Linzen


    Full Text Available Speakers judge novel strings to be better potential words of their language if those strings consist of sound sequences that are attested in the language. These intuitions are often generalized to new sequences that share some properties with attested ones: Participants exposed to an artificial language where all words start with the voiced stops [b] and [d] will prefer words that start with other voiced stops (e.g., [g] to words that start with vowels or nasals. The current study tracks the evolution of generalization across sounds during the early stages of artificial language learning. In Experiments 1 and 2, participants received varying amounts of exposure to an artificial language. Learners rapidly generalized to new sounds: In fact, following short exposure to the language, attested patterns were not distinguished from unattested patterns that were similar in their phonological properties to the attested ones. Following additional exposure, participants showed an increasing preference for attested sounds, alongside sustained generalization to unattested ones. Finally, Experiment 3 tested whether participants can rapidly generalize to new sounds based on a single type of sound. We discuss the implications of our results for computational models of phonotactic learning.

  15. Rapid ISS Power Availability Simulator (United States)

    Downing, Nicholas


    The ISS (International Space Station) Power Resource Officers (PROs) needed a tool to automate the calculation of thousands of ISS power availability simulations used to generate power constraint matrices. Each matrix contains 864 cells, and each cell represents a single power simulation that must be run. The tools available to the flight controllers were very operator intensive and not conducive to rapidly running the thousands of simulations necessary to generate the power constraint data. SOLAR is a Java-based tool that leverages commercial-off-the-shelf software (Satellite Toolkit) and an existing in-house ISS EPS model (SPEED) to rapidly perform thousands of power availability simulations. SOLAR has a very modular architecture and consists of a series of plug-ins that are loosely coupled. The modular architecture of the software allows for the easy replacement of the ISS power system model simulator, re-use of the Satellite Toolkit integration code, and separation of the user interface from the core logic. Satellite Toolkit (STK) is used to generate ISS eclipse and insulation times, solar beta angle, position of the solar arrays over time, and the amount of shadowing on the solar arrays, which is then provided to SPEED to calculate power generation forecasts. The power planning turn-around time is reduced from three months to two weeks (83-percent decrease) using SOLAR, and the amount of PRO power planning support effort is reduced by an estimated 30 percent.


    Energy Technology Data Exchange (ETDEWEB)

    Costa, A. D.; Martins, B. L. Canto; Bravo, J. P.; Paz-Chinchón, F.; Chagas, M. L. das; Leão, I. C.; Oliveira, G. Pereira de; Silva, R. Rodrigues da; Roque, S.; Oliveira, L. L. A. de; Silva, D. Freire da; De Medeiros, J. R., E-mail: [Departamento de Física Teórica e Experimental, Universidade Federal do Rio Grande do Norte, Campus Universitário, Natal RN (Brazil)


    Rapidly rotating giant stars are relatively rare and may represent important stages of stellar evolution, resulting from stellar coalescence of close binary systems or accretion of substellar companions by their hosting stars. In the present Letter, we report 17 giant stars observed in the scope of the Kepler space mission exhibiting rapid rotation behavior. For the first time, the abnormal rotational behavior for this puzzling family of stars is revealed by direct measurements of rotation, namely from photometric rotation period, exhibiting a very short rotation period with values ranging from 13 to 55 days. This finding points to remarkable surface rotation rates, up to 18 times the rotation of the Sun. These giants are combined with six others recently listed in the literature for mid-infrared (IR) diagnostics based on Wide-field Infrared Survey Explorer information, from which a trend for an IR excess is revealed for at least one-half of the stars, but at a level far lower than the dust excess emission shown by planet-bearing main-sequence stars.

  17. Rapid starting methanol reactor system (United States)

    Chludzinski, Paul J.; Dantowitz, Philip; McElroy, James F.


    The invention relates to a methanol-to-hydrogen cracking reactor for use with a fuel cell vehicular power plant. The system is particularly designed for rapid start-up of the catalytic methanol cracking reactor after an extended shut-down period, i.e., after the vehicular fuel cell power plant has been inoperative overnight. Rapid system start-up is accomplished by a combination of direct and indirect heating of the cracking catalyst. Initially, liquid methanol is burned with a stoichiometric or slightly lean air mixture in the combustion chamber of the reactor assembly. The hot combustion gas travels down a flue gas chamber in heat exchange relationship with the catalytic cracking chamber transferring heat across the catalyst chamber wall to heat the catalyst indirectly. The combustion gas is then diverted back through the catalyst bed to heat the catalyst pellets directly. When the cracking reactor temperature reaches operating temperature, methanol combustion is stopped and a hot gas valve is switched to route the flue gas overboard, with methanol being fed directly to the catalytic cracking reactor. Thereafter, the burner operates on excess hydrogen from the fuel cells.

  18. Rapidly Developing Toxic Epidermal Necrolysis

    Directory of Open Access Journals (Sweden)

    Viktoria Oline Barrios Poulsen


    Full Text Available Severe cutaneous reactions with potentially fatal outcomes can have many different causes. The Stevens-Johnson syndrome (SJS and toxic epidermal necrolysis (TEN are rare. They are characterized by a low incidence but high mortality, and drugs are most commonly implicated. Urgent active therapy is required. Prompt recognition and withdrawal of suspect drug and rapid intervention can result in favourable outcome. No further international guidelines for treatment exist, and much of the treatment relies on old or experimental concepts with no scientific evidence. We report on a 54-year-old man experiencing rapidly developing drug-induced severe TEN and presented multiorgan failure involving the respiratory and circulatory system, coagulopathy, and renal insufficiency. Detachment counted 30% of total body surface area (TBSA. SCORTEN = 5, indicating a mortality rate >90%. The patient was sedated and mechanically ventilated, supported with fluids and inotropes to maintain a stable circulation. Component therapy was guided by thromboelastography (TEG. The patient received plasmapheresis, and shock reversal treatment was initiated. He was transferred to a specialized intensive care burn unit within 24 hours from admittance. The initial care was continued, and hemodialysis was started. Pulmonary, circulatory, and renal sequelae resolved with intensive care, and re-epithelialization progressed slowly. The patient was discharged home on hospital day 19.

  19. Deconstructing Technological Literacy: Opening a Window to Problem Solving (United States)

    Ward, Brandt


    In an environment of rapid and unpredictable change determined and directed by technologies that are constantly changing, the assumption that being technologically literate is the key to being a sustained, contributing life-long learner is well founded. However, technological literacy is seldom referred to or considered in academic arguments as a…

  20. Fostering Information and Communication Technology Literacy: Insights from Telecommunications Services (United States)

    Winter, Jenifer S.


    The author argues that the rapid growth of information and communication technologies and an increasingly complex global environment have brought about the need for information and communication technology (ICT) literacy, the ability to use information technology effectively and evaluate its role in society critically. She presents a strategy for…

  1. Utah Elementary School Principals Preparation as Technology Leaders (United States)

    Esplin, Nathan L.


    The rapidly expanding use of technology in education has brought about the need for principals to be prepared as technology leaders. Although, there is a need for principals to be prepared as technology leaders, many currently are not prepared for this role. It is crucial that principals are prepared in order ability to lead their school in…

  2. Seafood Technology

    DEFF Research Database (Denmark)

    Børresen, Torger

    This presentation will fill the total picture of this conference between fisheries and aquaculture, blue biotech and bioconservation, by considering the optimal processing technology of marine resources from the raw material until the seafood reaches the plate of the consumer. The situation today...... must be performed such that total traceability and authenticity of the final products can be presented on demand. The most important aspects to be considered within seafood technology today are safety, healthy products and high eating quality. Safety can be divided into microbiological safety...... and not presenting any safety risk per se. Seafood is healthy due to the omega-3 fatty acids and the nutritional value of vitamins, peptides and proteins. The processing technology must however be performed such that these valuable features are not lost during production. The same applies to the eating quality. Any...

  3. Technology Management

    DEFF Research Database (Denmark)

    Pilkington, Alan


    This paper reports a bibliometric analysis (co-citation network analysis) of 10 journals in the management of technology (MOT) field. As well as introducing various bibliometric ideas, network analysis tools identify and explore the concepts covered by the field and their inter-relationships. Spe......This paper reports a bibliometric analysis (co-citation network analysis) of 10 journals in the management of technology (MOT) field. As well as introducing various bibliometric ideas, network analysis tools identify and explore the concepts covered by the field and their inter......-relationships. Specific results from different levels of analysis show the different dimensions of technology management: • Co-word terms identify themes • Journal co-citation network: linking to other disciplines • Co-citation network show concentrations of themes The analysis shows that MOT has a bridging role...

  4. Persuasive Technology

    DEFF Research Database (Denmark)

    This book constitutes the proceedings of the 5th International Conference on Persuasive Technology, PERSUASIVE 2010, held in Copenhagen Denmark in June 2010. The 25 papers presented were carefully reviewed and selected from 80 submissions. In addition three keynote papers are included in this vol......This book constitutes the proceedings of the 5th International Conference on Persuasive Technology, PERSUASIVE 2010, held in Copenhagen Denmark in June 2010. The 25 papers presented were carefully reviewed and selected from 80 submissions. In addition three keynote papers are included...... in this volume. The topics covered are emotions and user experience, ambient persuasive systems, persuasive design, persuasion profiles, designing for health, psychology of persuasion, embodied and conversational agents, economic incentives, and future directions for persuasive technology....

  5. Sensitivity and specificity of rapid HIV testing of pregnant women in India. (United States)

    Bhore, A V; Sastry, J; Patke, D; Gupte, N; Bulakh, P M; Lele, S; Karmarkar, A; Bharucha, K E; Shrotri, A; Pisal, H; Suryawanshi, N; Tripathy, S; Risbud, A R; Paranjape, R S; Shankar, A V; Kshirsagar, A; Phadke, M A; Joshi, P L; Brookmeyer, R S; Bollinger, R C


    Efforts to prevent HIV transmission from mother to infants in settings like India may benefit from the availability of reliable methods for rapid and simple HIV screening. Data from India on the reliability of rapid HIV test kits are limited and there are no data on the use of rapid HIV tests for screening of pregnant women. Pregnant women attending an antenatal clinic and delivery room in Pune agreed to participate in an evaluation of five rapid HIV tests, including (a) a saliva brush test (Oraquick HIV-1/2, Orasure Technologies Inc.), (b) a rapid plasma test (Oraquick HIV-1/2) and (c) three rapid finger prick tests (Oraquick HIV-1/2; HIV-1/2 Determine, Abbott; NEVA HIV-1/2 Cadila). Results of the rapid tests were compared with three commercial plasma enzyme immunoassay (EIA) tests (Innotest HIV AB EIA, Lab systems/ELISCAN HIV AB EIA, UBI HIV Ab EIA). Between September 2000 and October 1, 2001, 1258 pregnant women were screened for HIV using these rapid tests. Forty-four (3.49%) of the specimens were HIV-antibody-positive by at least two plasma EIA tests. All of the rapid HIV tests demonstrated excellent specificity (96-100%). The sensitivity of the rapid tests ranged from 75-94%. The combined sensitivity and specificity of a two-step algorithm for rapid HIV testing was excellent for a number of combinations of the five rapid finger stick tests. In this relatively low HIV prevalence population of pregnant women in India, the sensitivity of the rapid HIV tests varied, when compared to a dual EIA algorithm. In general, the specificity of all the rapid tests was excellent, with very few false positive HIV tests. Based upon these data, two different rapid HIV tests for screening pregnant women in India would be highly sensitive, with excellent specificity to reliably prevent inappropriate use of antiretroviral therapy for prevention of vertical HIV transmission.

  6. Lab-on-fiber technology

    CERN Document Server

    Cusano, Andrea; Crescitelli, Alessio; Ricciardi, Armando


    This book focuses on a research field that is rapidly emerging as one of the most promising ones for the global optics and photonics community: the "lab-on-fiber" technology. Inspired by the well-established 'lab on-a-chip' concept, this new technology essentially envisages novel and highly functionalized devices completely integrated into a single optical fiber for both communication and sensing applications.Based on the R&D experience of some of the world's leading authorities in the fields of optics, photonics, nanotechnology, and material science, this book provides a broad and accurate de

  7. Architectural technology

    DEFF Research Database (Denmark)


    The booklet offers an overall introduction to the Institute of Architectural Technology and its projects and activities, and an invitation to the reader to contact the institute or the individual researcher for further information. The research, which takes place at the Institute of Architectural...... Technology at the Roayl Danish Academy of Fine Arts, School of Architecture, reflects a spread between strategic, goal-oriented pilot projects, commissioned by a ministry, a fund or a private company, and on the other hand projects which originate from strong personal interests and enthusiasm of individual...

  8. Playful Technology

    DEFF Research Database (Denmark)

    Johansen, Stine Liv; Eriksson, Eva


    In this paper, the design of future services for children in Danish public libraries is discussed, in the light of new challenges and opportunities in relation to new media and technologies. The Danish government has over the last few years initiated and described a range of initiatives regarding...... in the library, the changing role of the librarians and the library space. We argue that intertwining traditional library services with new media forms and engaging play is the core challenge for future design in physical public libraries, but also that it is through new media and technology that new...

  9. Technology applications (United States)

    Anuskiewicz, T.; Johnston, J.; Leavitt, W.; Zimmerman, R. R.


    A summary of NASA Technology Utilization programs for the period of 1 December 1971 through 31 May 1972 is presented. An abbreviated description of the overall Technology Utilization Applications Program is provided as a background for the specific applications examples. Subjects discussed are in the broad headings of: (1) cancer, (2) cardiovascular disease, (2) medical instrumentation, (4) urinary system disorders, (5) rehabilitation medicine, (6) air and water pollution, (7) housing and urban construction, (8) fire safety, (9) law enforcement and criminalistics, (10) transportation, and (11) mine safety.

  10. Rapid prototyping--when virtual meets reality. (United States)

    Beguma, Zubeda; Chhedat, Pratik


    Rapid prototyping (RP) describes the customized production of solid models using 3D computer data. Over the past decade, advances in RP have continued to evolve, resulting in the development of new techniques that have been applied to the fabrication of various prostheses. RP fabrication technologies include stereolithography (SLA), fused deposition modeling (FDM), computer numerical controlled (CNC) milling, and, more recently, selective laser sintering (SLS). The applications of RP techniques for dentistry include wax pattern fabrication for dental prostheses, dental (facial) prostheses mold (shell) fabrication, and removable dental prostheses framework fabrication. In the past, a physical plastic shape of the removable partial denture (RPD) framework was produced using an RP machine, and then used as a sacrificial pattern. Yet with the advent of the selective laser melting (SLM) technique, RPD metal frameworks can be directly fabricated, thereby omitting the casting stage. This new approach can also generate the wax pattern for facial prostheses directly, thereby reducing labor-intensive laboratory procedures. Many people stand to benefit from these new RP techniques for producing various forms of dental prostheses, which in the near future could transform traditional prosthodontic practices.

  11. Web tools for rapid experimental visualization prototyping (United States)

    Decker, Jonathan W.; Livingstion, Mark A.


    Quite often a researcher finds themselves looking at spreadsheets of high-dimensional data generated by experimental models and user studies. We can use analysis to challenge or confirm hypothesis, but unexpected results can easily be lost in the shuffle. For this reason, it would be useful to visualize the results so we can explore our data and make new discoveries. Web browsers have become increasingly capable for creating complex, multi-view applications. Javascript is quickly becoming a de facto standard for scripting, online and offline. This work demonstrates the use of web technologies as a powerful tool for rapid visualization prototyping. We have developed two prototypes: One for high-dimensional results of the abELICIT - multi-agent version of the ELICIT platform tasked with collaborating to identify the parameters of a pending attack. Another prototype displays responses to a user study on the effectiveness of multi-layer visualization techniques. We created coordinated multiple views prototypes in the Google Chrome web browser written in Javascript, CSS and HTML. We will discuss the benefits and shortcomings of this approach.

  12. Rapid innovation diffusion in social networks. (United States)

    Kreindler, Gabriel E; Young, H Peyton


    Social and technological innovations often spread through social networks as people respond to what their neighbors are doing. Previous research has identified specific network structures, such as local clustering, that promote rapid diffusion. Here we derive bounds that are independent of network structure and size, such that diffusion is fast whenever the payoff gain from the innovation is sufficiently high and the agents' responses are sufficiently noisy. We also provide a simple method for computing an upper bound on the expected time it takes for the innovation to become established in any finite network. For example, if agents choose log-linear responses to what their neighbors are doing, it takes on average less than 80 revision periods for the innovation to diffuse widely in any network, provided that the error rate is at least 5% and the payoff gain (relative to the status quo) is at least 150%. Qualitatively similar results hold for other smoothed best-response functions and populations that experience heterogeneous payoff shocks.

  13. Rapid prototype modeling in a multimodality world (United States)

    Bidaut, Luc; Madewell, John; Yasko, Alan


    Introduction: Rapid prototype modeling (RPM) has been used in medicine principally for bones - that are easily extracted from CT data sets - for planning orthopaedic, plastic or maxillo-facial interventions, and/or for designing custom prostheses and implants. Based on newly available technology, highly valuable multimodality approaches can now be applied to RPM, particularly for complex musculo-skeletal (MSK) tumors where multimodality often transcends CT alone. Methods: CT data sets are acquired for primary evaluation of MSK tumors in parallel with other modalities (e.g., MR, PET, SPECT). In our approach, CT is first segmented to provide bony anatomy for RPM and all other data sets are then registered to the CT reference. Parametric information relevant to the tumor's characterization is then extracted from the multimodality space and merged with the CT anatomy to produce a hybrid RPM-ready model. This model - that also accommodates digital multimodality visualization - is then produced on the latest generation of 3D printers, which permits both shapes and colors. Results: Multimodality models of complex MSK tumors have been physically produced on modern RPM equipment. This new approach has been found to be a clear improvement over the previously disconnected physical RPM and digital multimodality visualization. Conclusions: New technical developments keep opening doors to sophisticated medical applications that can directly impact the quality of patient care. Although this early work still deals with bones as base models for RPM, its use to encompass soft tissues is already envisioned for future approaches.

  14. Rapid Raman mapping of a fulgurite. (United States)

    Carter, Elizabeth A; Pasek, Matthew A; Smith, Tim; Kee, Terence P; Hines, Peter; Edwards, Howell G M


    A fulgurite is a naturally occurring glass formed when lightning hits sand, rock, or soil. The formation of fulgurites is accompanied by mineralogical and sometimes compositional changes, and may record information about the environment in which they were formed. A previous investigation using Raman point spectroscopy discovered the presence of anatase, a low-temperature polymorph of TiO(2), and polyaromatic hydrocarbons within a fulgurite. These findings indicate that there were regions within the sample that were not subjected to temperatures of 2,000 K or more that the matrix is reported to attain when struck by lightning. This paper seeks to expand the previous research by utilizing the capabilities of a new Raman spectroscopic technological development that enables rapid mapping. The entire surface area of a cross-sectioned fulgurite (approximately 40 mm x 23 mm) sample was mapped allowing several regions of polyaromatic hydrocarbons and anatase to be located. Furthermore, shocked quartz was found within the boundary regions of the fulgurite, and is proposed to have resulted from contact with vaporized material during the lightning strike. Shocked quartz is typically indicative of extraterrestrial impact, yet its discovery here suggests that its formation is not exclusive to the impact process.

  15. Joint collaborative technology experiment (United States)

    Wills, Michael; Ciccimaro, Donny; Yee, See; Denewiler, Thomas; Stroumtsos, Nicholas; Messamore, John; Brown, Rodney; Skibba, Brian; Clapp, Daniel; Wit, Jeff; Shirts, Randy J.; Dion, Gary N.; Anselmo, Gary S.


    Use of unmanned systems is rapidly growing within the military and civilian sectors in a variety of roles including reconnaissance, surveillance, explosive ordinance disposal (EOD), and force-protection and perimeter security. As utilization of these systems grows at an ever increasing rate, the need for unmanned systems teaming and inter-system collaboration becomes apparent. Collaboration provides a means of enhancing individual system capabilities through relevant data exchange that contributes to cooperative behaviors between systems and enables new capabilities not possible if the systems operate independently. A collaborative networked approach to development holds the promise of adding mission capability while simultaneously reducing the workload of system operators. The Joint Collaborative Technology Experiment (JCTE) joins individual technology development efforts within the Air Force, Navy, and Army to demonstrate the potential benefits of interoperable multiple system collaboration in a force-protection application. JCTE participants are the Air Force Research Laboratory, Materials and Manufacturing Directorate, Airbase Technologies Division, Force Protection Branch (AFRL/RXQF); the Army Aviation and Missile Research, Development, and Engineering Center Software Engineering Directorate (AMRDEC SED); and the Space and Naval Warfare Systems Center - Pacific (SSC Pacific) Unmanned Systems Branch operating with funding provided by the Joint Ground Robotics Enterprise (JGRE). This paper will describe the efforts to date in system development by the three partner organizations, development of collaborative behaviors and experimentation in the force-protection application, results and lessons learned at a technical demonstration, simulation results, and a path forward for future work.

  16. "Infotonics Technology Center"

    Energy Technology Data Exchange (ETDEWEB)

    Fritzemeier, L. [Infotonics Technology Center Inc., Canandaigua, NY (United States); Boysel, M. B. [Infotonics Technology Center Inc., Canandaigua, NY (United States); Smith, D. R. [Infotonics Technology Center Inc., Canandaigua, NY (United States)


    During this grant period July 15, 2002 thru September 30, 2004, the Infotonics Technology Center developed the critical infrastructure and technical expertise necessary to accelerate the development of sensors, alternative lighting and power sources, and other specific subtopics of interest to Department of Energy. Infotonics fosters collaboration among industry, universities and government and operates as a national center of excellence to drive photonics and microsystems development and commercialization. A main goal of the Center is to establish a unique, world-class research and development facility. A state-of-the-art microsystems prototype and pilot fabrication facility was established to enable rapid commercialization of new products of particular interest to DOE. The Center has three primary areas of photonics and microsystems competency: device research and engineering, packaging and assembly, and prototype and pilot-scale fabrication. Center activities focused on next generation optical communication networks, advanced imaging and information sensors and systems, micro-fluidic systems, assembly and packaging technologies, and biochemical sensors. With targeted research programs guided by the wealth of expertise of Infotonics business and scientific staff, the fabrication and packaging facility supports and accelerates innovative technology development of special interest to DOE in support of its mission and strategic defense, energy, and science goals.

  17. Technology Transfer: Marketing Tomorrow's Technology (United States)

    Tcheng, Erene


    The globalization of the economy and the end of the Cold War have triggered many changes in the traditional practices of U.S. industry. To effectively apply the resources available to the United States, the federal government has firmly advocated a policy of technology transfer between private industry and government labs, in this case the National Aeronautics and Space Administration (NASA). NASA Administrator Daniel Goldin is a strong proponent of this policy and has organized technology transfer or commercialization programs at each of the NASA field centers. Here at Langley Research Center, the Technology Applications Group (TAG) is responsible for facilitating the transfer of Langley developed research and technology to U.S. industry. Entering the program, I had many objectives for my summer research with TAG. Certainly, I wanted to gain a more thorough understanding of the concept of technology transfer and Langley's implementation of a system to promote it to both the Langley community and the community at large. Also, I hoped to become more familiar with Langley's research capabilities and technology inventory available to the public. More specifically, I wanted to learn about the technology transfer process at Langley. Because my mentor is a member of Materials and Manufacturing marketing sector of the Technology Transfer Team, another overriding objective for my research was to take advantage of his work and experience in materials research to learn about the Advanced Materials Research agency wide and help market these developments to private industry. Through the various projects I have been assigned to work on in TAG, I have successfully satisfied the majority of these objectives. Work on the Problem Statement Process for TAG as well as the development of the Advanced Materials Research Brochure have provided me with the opportunity to learn about the technology transfer process from the outside looking in and the inside looking out. Because TAG covers

  18. Holography: The Next Disruptive Technology (United States)


    rapidly changing technological advances in holography and how it could transform the Army’s in-theater tactics as well as training and...Approved for public release; distribution is unlimited. 2 Part I of this report will focus on materials and chemistries investigated for these...Defense Advanced Research Projects Agency partnered with Zebra Imaging to produce a prototype of the ZScape Motion Display for a real-time streaming

  19. Manufacturing technologies

    Energy Technology Data Exchange (ETDEWEB)



    The Manufacturing Technologies Center is an integral part of Sandia National Laboratories, a multiprogram engineering and science laboratory, operated for the Department of Energy (DOE) with major facilities at Albuquerque, New Mexico, and Livermore, California. Our Center is at the core of Sandia`s Advanced Manufacturing effort which spans the entire product realization process.

  20. (Environmental technology)

    Energy Technology Data Exchange (ETDEWEB)

    Boston, H.L.


    The traveler participated in a conference on environmental technology in Paris, sponsored by the US Embassy-Paris, US Environmental Protection Agency (EPA), the French Environmental Ministry, and others. The traveler sat on a panel for environmental aspects of energy technology and made a presentation on the potential contributions of Oak Ridge National Laboratory (ORNL) to a planned French-American Environmental Technologies Institute in Chattanooga, Tennessee, and Evry, France. This institute would provide opportunities for international cooperation on environmental issues and technology transfer related to environmental protection, monitoring, and restoration at US Department of Energy (DOE) facilities. The traveler also attended the Fourth International Conference on Environmental Contamination in Barcelona. Conference topics included environmental chemistry, land disposal of wastes, treatment of toxic wastes, micropollutants, trace organics, artificial radionuclides in the environment, and the use biomonitoring and biosystems for environmental assessment. The traveler presented a paper on The Fate of Radionuclides in Sewage Sludge Applied to Land.'' Those findings corresponded well with results from studies addressing the fate of fallout radionuclides from the Chernobyl nuclear accident. There was an exchange of new information on a number of topics of interest to DOE waste management and environmental restoration needs.

  1. Living Technologies

    Indian Academy of Sciences (India)

    might help explore Mars [2]. The US space agency NASA was immensely impressed by the devices and has plans to utilize the technology on a 2007 mission to the red planet to explore the rock structure of the Valles Marineris, the largest canyon of the solar system. The scientists demonstrated navigational and flight.

  2. Appropriate technology

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC's core goal has always been to help researchers in developing countries tackle the problems that they themselves have identified. Some of the innovations that have resulted are strikingly simple and small-scale; others rely on advanced knowledge and sophisticated tools. In each case, however, the technologies ...

  3. Lasers technology

    Energy Technology Data Exchange (ETDEWEB)



    The Lasers Technology Program of IPEN is strongly committed to the study of Laser Applications on several areas: Nuclear, Medicine and Dentistry, Industry, Environment and Advanced research, aiming not only research but diffusion and innovation in association with Brazilian universities and commercial partners.

  4. Videodisc Technology. (United States)

    Marsh, Fred E., Jr.


    Identifies and describes the major areas of videodisc technology; discusses the operation, reliability, storage capacities, and applications of two types of laser systems; and illustrates the versatility of the optical digital disc through a description of its ability to digitize large bodies of data. Included are six figures and three tables.…

  5. [Rapid diagnostic test for malaria]. (United States)

    Houzé, S


    The rapid diagnostic tests (RDTs) whose main interest lies in their implementation without special equipment by unskilled personnel have grown significantly over the past fifteen years to diagnose malaria. They rely on the detection of specific Plasmodium proteins, PfHRP2, pLDH and aldolase. If the detection of PfHRP2 has very good sensitivity for the diagnosis of Plasmodium falciparum malaria, the detection of pLDH or aldolase is less efficient for other species, leaving its place to the reference microscopic diagnosis. RDT could not generally be used to monitor therapeutic efficacy because they can remain positive after clinical and parasitological cure. Furthermore, the development of the use of these tests has highlighted the need for quality assurance programs to monitor their production as their use.

  6. Rapid Solidification of Magnetic Oxides (United States)

    Kalonji, G.; Deguire, M. R.


    The enhanced control over microstructural evolution inherent in rapid solidification processing techniques are exploited to create novel ceramic magnetic materials. The great sensitivity of magnetic properties to local structure provides a powerful probe both for the study of structure and of microscopic solidification mechanisms. The first system studied is the SrO-Fe2O3 binary, which contains the commercially important hard magnetic compound strontium hexaferrite. The products were analyzed by transmission electron microscopy, Mossbauer spectroscopy, magnetic measurements, and differential thermal analysis. As-quenched ribbons contain high concentrations of super-paramagnetic particles, 80 to 250 Angstroms in diameter, in a glassy matrix. This suggests the possibility of crystallizing monodomain strontium hexaferrite during subsequent heat treatment, with a resulting increase in coercivity over conventionally processed ferrite magnets. That magnetic properties can be controlled in solidification processing by varying the quench rate is demonstrated.

  7. The Information and Communication Technologies, Learning and Knowledge Technologies and Technologies for Empowerment and Participation as Tools to Support the University Teachers of the XXI Century


    John Granados Romero; Raúl López Fernández; Raidell Avello Martínez; Diego Luna Álvarez; Enrique Luna Álvarez; Walter Luna Álvarez


    The learning environment has suffered major transformations with the rapid development of the information and communications technologies; in this context the concept of learning and knowledge technologies and technologies for the empowerment and participation emerges. This paper aims at contributing to the reflection on the use of information and communication technologies that must be continually made in education, especially among teachers of the 21st century University. As main result, so...

  8. Application study of nuclear technologies for integration chemical, biological and radiological technology

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jae Kon; Han, M. H.; Kim, Y. H.; Yang, J. E.; Jung, K. S.; Cha, H. K.; Moon, J.; La, K. H


    The projects are suggested the method to maximize the technology and research results which are being carried out by KAERI on the nuclear field. The study presents 1)the technology to rapidly and accurately determine and the nature of contamination, 2) the technology to predict the spread of contaminant and the magnitude of damage, and 3) the expert-aided decision making technology to identify the optimum counter-measures. And the solutions are also suggested the application to military technology in Chemical, Biological and Radiation field. In addition, I hope this kind of cooperation model come to be the good case of military civilian research harmony to improve the national competition capability.

  9. Vacuum Technology

    Energy Technology Data Exchange (ETDEWEB)

    Biltoft, P J


    The environmental condition called vacuum is created any time the pressure of a gas is reduced compared to atmospheric pressure. On earth we typically create a vacuum by connecting a pump capable of moving gas to a relatively leak free vessel. Through operation of the gas pump the number of gas molecules per unit volume is decreased within the vessel. As soon as one creates a vacuum natural forces (in this case entropy) work to restore equilibrium pressure; the practical effect of this is that gas molecules attempt to enter the evacuated space by any means possible. It is useful to think of vacuum in terms of a gas at a pressure below atmospheric pressure. In even the best vacuum vessels ever created there are approximately 3,500,000 molecules of gas per cubic meter of volume remaining inside the vessel. The lowest pressure environment known is in interstellar space where there are approximately four molecules of gas per cubic meter. Researchers are currently developing vacuum technology components (pumps, gauges, valves, etc.) using micro electro mechanical systems (MEMS) technology. Miniature vacuum components and systems will open the possibility for significant savings in energy cost and will open the doors to advances in electronics, manufacturing and semiconductor fabrication. In conclusion, an understanding of the basic principles of vacuum technology as presented in this summary is essential for the successful execution of all projects that involve vacuum technology. Using the principles described above, a practitioner of vacuum technology can design a vacuum system that will achieve the project requirements.

  10. The Competitive Technology Environment for LED Lighting (United States)

    Devonshire, Robin

    Solid state lighting (SSL) systems are set to begin competing with a number of mature lighting technologies in mainstream markets for narrow- and wide-area illumination. The paper provides a summary overview of the present state of the established illumination lighting sector in terms of its scale and global energy usage, and its core technologies and their major performance characteristics. The established technologies are themselves still evolving in response generally to growing, world-wide, legislative and environmental pressures, and also, no doubt, to the stimulus provided by the rapid advances in the performance of white-LED modules. Several promising new thermal and discharge lamp technologies are identified and discussed briefly.

  11. Advanced location-based technologies and services

    CERN Document Server

    Karimi, Hassan A


    Due to the rapid increase in the number of mobile device users worldwide, location-based services (LBSs) have become pervasive, and the demand for them will continue to grow. Exploring recent changes in the technology and its uses, Advanced Location-Based Technologies and Services takes an in-depth look at new and existing technologies, techniques, applications, and opportunities. Under the editorial guidance of Hassan Karimi, with contributions from experts in the field, the book examines the breadth and depth of advanced LBS technologies and techniques. The book provides up-to-date informati

  12. Ceramic microfabrication by rapid prototyping process chains

    Indian Academy of Sciences (India)

    To avoid high tooling costs in product development, a rapid prototyping process chain has been established that enables rapid manufacturing of ceramic microcomponents from functional models to small lot series within a short time. This process chain combines the fast and inexpensive supply of master models by rapid ...

  13. Rapid Prototyping in Instructional Design: Creating Competencies (United States)

    Fulton, Carolyn D.


    Instructional designers working in rapid prototyping environments currently do not have a list of competencies that help to identify the knowledge, skills, and attitudes (KSAs) required in these workplaces. This qualitative case study used multiple cases in an attempt to identify rapid prototyping competencies required in a rapid prototyping…

  14. Economic Growth of a Rapidly Developing Economy: Theoretical Formulation

    Directory of Open Access Journals (Sweden)

    Oleg Sergeyevich Sukharev


    Full Text Available The subject matter of the article is the description of economic growth. Modern economy is characterized by a high rate of changes. These changes are the limiting parameters of modern development, which requires a modification of the basic models of growth, the substantiation of the expediency and necessity of a rapid development strategy. In a simple mathematical form, the statement of the problem of economic growth in the “green economy” is examined, in which the costs of environmental measures are not considered a priori as hampering economic development (as it is common for a number of modern neoclassical and neo-Keynesian growth models. The methodological basis of the article are the econometric approach and modelling method. The article has a theoretical character. The main hypothesis supposes that the rapid development strategy cannot make an adequate development strategy under certain conditions, but may be acceptable in other its specific conditions. In this sense, the important growth conditions are the availability of resources, the effectiveness of institutions and the current economic structure, the technological effectiveness of economy, as well as the conditions of technological development (“green economy” and the path of such development. In the article, on the theoretical level of analysis, the substantiation of the adequacy of the rapid development strategy for an economic system is given, whose goal is to achieve the standard of living of the countryleader. Based on the assumptions introduced, the period for which the rapid development strategy might be implemented and the economic lag of the country might be reduced from the country-leader is determined. The conditions that ensure the impact of innovations on the rate of economic development are summarized. The introduced range of dependencies and relations can be useful for the elaboration of the theory of innovation development and for the formation of a new

  15. Plant stress analysis technology deployment

    Energy Technology Data Exchange (ETDEWEB)

    Ebadian, M.A.


    Monitoring vegetation is an active area of laser-induced fluorescence imaging (LIFI) research. The Hemispheric Center for Environmental Technology (HCET) at Florida International University (FIU) is assisting in the transfer of the LIFI technology to the agricultural private sector through a market survey. The market survey will help identify the key eco-agricultural issues of the nations that could benefit from the use of sensor technologies developed by the Office of Science and Technology (OST). The principal region of interest is the Western Hemisphere, particularly, the rapidly growing countries of Latin America and the Caribbean. The analysis of needs will assure that the focus of present and future research will center on economically important issues facing both hemispheres. The application of the technology will be useful to the agriculture industry for airborne crop analysis as well as in the detection and characterization of contaminated sites by monitoring vegetation. LIFI airborne and close-proximity systems will be evaluated as stand-alone technologies and additions to existing sensor technologies that have been used to monitor crops in the field and in storage.

  16. Psychology, technology, and diabetes management. (United States)

    Gonder-Frederick, Linda A; Shepard, Jaclyn A; Grabman, Jesse H; Ritterband, Lee M


    Use of technology in diabetes management is rapidly advancing and has the potential to help individuals with diabetes achieve optimal glycemic control. Over the past 40 years, several devices have been developed and refined, including the blood glucose meter, insulin pump, and continuous glucose monitor. When used in tandem, the insulin pump and continuous glucose monitor have prompted the Artificial Pancreas initiative, aimed at developing control system for fully automating glucose monitoring and insulin delivery. In addition to devices, modern technology, such as the Internet and mobile phone applications, have been used to promote patient education, support, and intervention to address the behavioral and emotional challenges of diabetes management. These state-of-the-art technologies not only have the potential to improve clinical outcomes, but there are possible psychological benefits, such as improved quality of life, as well. However, practical and psychosocial limitations related to advanced technology exist and, in the context of several technology-related theoretical frameworks, can influence patient adoption and continued use. It is essential for future diabetes technology research to address these barriers given that the clinical benefits appear to largely depend on patient engagement and consistence of technology use. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  17. Technology Foresight: A Tool for sustainability

    Directory of Open Access Journals (Sweden)

    Iraj Nabipour


    Full Text Available Our age is one of very rapid progress in the sciences and technologies, together with Globalization. Thus, interrelationships between science, technology and society are becoming more complex. This makes economic and social trends more difficult to predict and hence, more sophisticated approaches are needed to predict new challenges in science and technology. Technology foresight is the most attractive approach. In fact, technology foresight is a “… a systematic means of assessing those scientific and technological developments which could have a strong impact on industrial competitiveness, wealth creation and quality of life. This book presents a brief review or foresighting theory and methods. The book provides a series of key methodologies along with a discussion of how technology foresight relates to sustainability.

  18. Onboard Radar Processing Development for Rapid Response Applications (United States)

    Lou, Yunling; Chien, Steve; Clark, Duane; Doubleday, Josh; Muellerschoen, Ron; Wang, Charles C.


    We are developing onboard processor (OBP) technology to streamline data acquisition on-demand and explore the potential of the L-band SAR instrument onboard the proposed DESDynI mission and UAVSAR for rapid response applications. The technology would enable the observation and use of surface change data over rapidly evolving natural hazards, both as an aid to scientific understanding and to provide timely data to agencies responsible for the management and mitigation of natural disasters. We are adapting complex science algorithms for surface water extent to detect flooding, snow/water/ice classification to assist in transportation/ shipping forecasts, and repeat-pass change detection to detect disturbances. We are near completion of the development of a custom FPGA board to meet the specific memory and processing needs of L-band SAR processor algorithms and high speed interfaces to reformat and route raw radar data to/from the FPGA processor board. We have also developed a high fidelity Matlab model of the SAR processor that is modularized and parameterized for ease to prototype various SAR processor algorithms targeted for the FPGA. We will be testing the OBP and rapid response algorithms with UAVSAR data to determine the fidelity of the products.

  19. Technology Programme

    Energy Technology Data Exchange (ETDEWEB)

    Batistoni, Paola; De Marco, Francesco; Pieroni, Leonardo (ed.)


    The technology activities carried out by the Euratom-ENEA Association in the framework of the European Fusion Development Agreement concern the Next Step (International Thermonuclear Experimental Reactor - ITER), the Long-Term Programme (breeder blanket, materials, International Fusion Materials Irradiation Facility - IFMIF), Power Plant Conceptual Studies and Socio-Economic Studies. The Underlying Technology Programme was set up to complement the fusion activities as well to develop technologies with a wider range of interest. The Technology Programme mainly involves staff from the Frascati laboratories of the Fusion Technical and Scientific Unit and from the Brasimone laboratories of the Advanced Physics Technologies Unit. Other ENEA units also provide valuable contributions to the programme. ENEA is heavily engaged in component development/testing and in design and safety activities for the European Fusion Technology Programme. Although the work documented in the following covers a large range of topics that differ considerably because they concern the development of extremely complex systems, the high level of integration and coordination ensures the capability to cover the fusion system as a whole. In 2004 the most significant testing activities concerned the ITER primary beryllium-coated first wall. In the field of high-heat-flux components, an important achievement was the qualification of the process for depositing a copper liner on carbon fibre composite (CFC) hollow tiles. This new process, pre-brazed casting (PBC), allows the hot radial pressing (HRP) joining procedure to be used also for CFC-based armour monoblock divertor components. The PBC and HRP processes are candidates for the construction of the ITER divertor. In the materials field an important milestone was the commissioning of a new facility for chemical vapour infiltration/deposition, used for optimising silicon carbide composite (SiCf/SiC) components. Eight patents were deposited during 2004

  20. Technology: Technology and Common Sense (United States)

    Van Horn, Royal


    The absence of common sense in the world of technology continues to amaze the author. Things that seem so logical to just aren nott for many people. The installation of Voice-over IP (VoIP, with IP standing for Internet Protocol) in many school districts is a good example. Schools have always had trouble with telephones. Many districts don't even…

  1. Rapid Determination Of Radiostrontium In Large Soil Samples

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, Sherrod L.; Culligan, Brian K.; Shaw, Patrick J.


    A new method for the determination of radiostrontium in large soil samples has been developed at the Savannah River Environmental Laboratory (Aiken, SC, USA) that allows rapid preconcentration and separation of strontium in large soil samples for the measurement of strontium isotopes by gas flow proportional counting. The need for rapid analyses in the event of a Radiological Dispersive Device (RDD) or Improvised Nuclear Device (IND) event is well-known. In addition, the recent accident at Fukushima Nuclear Power Plant in March, 2011 reinforces the need to have rapid analyses for radionuclides in environmental samples in the event of a nuclear accident. The method employs a novel pre-concentration step that utilizes an iron hydroxide precipitation (enhanced with calcium phosphate) followed by a final calcium fluoride precipitation to remove silicates and other matrix components. The pre-concentration steps, in combination with a rapid Sr Resin separation using vacuum box technology, allow very large soil samples to be analyzed for {sup 89,90}Sr using gas flow proportional counting with a lower method detection limit. The calcium fluoride precipitation eliminates column flow problems typically associated with large amounts of silicates in large soil samples.

  2. Recycling's technology


    A. Zajdel; R. Nowosielski


    Purpose: Environmental problems have been considered as serious situation in the construction. Waste management is pressing harder with alarming signal warning the industry. This paper discusses the potential impact of biodegradable materials on waste management in terms of landfill, incineration, recycle/reuse composting.Design/methodology/approach: This article reviewed the implementation of strategies of WEEE treatment and the recovery technologies of WEEE. It presented the current status ...

  3. ADSL Technology

    Directory of Open Access Journals (Sweden)

    Slavko Šarić


    Full Text Available The paper deals with the ADSL (Asymmetric Digital SubscriberLine technology- the asymmetric digital telecommunicationtechnology. It is characterised by high-speed transmissionof data and simultaneous transmission of information regardingthe throughput capacity of the telephone network. Thisresults in better efficiency of transmission, and higher utilisationof the bandwidth. Due to its advantages, the use of ADSLtechnology is increasing daily, especially by ente1prises in Europeand worldwide.

  4. Information technologies in biomedicine

    CERN Document Server

    Kawa, Jacek; Wieclawek, Wojciech


    New computerized approaches to various problems have become critically important in healthcare. Computer assisted diagnosis has been extended towards a support of the clinical treatment. Mathematical information analysis, computer applications have become standard tools underpinning the current rapid progress with developing Computational Intelligence. A computerized support in the analysis of patient information and implementation of a computer aided diagnosis and treatment systems, increases the objectivity of the analysis and speeds up the response to pathological changes. This book presents a variety of state-of-the-art information technology and its applications to the networked environment to allow robust computerized approaches to be introduced throughout the healthcare enterprise. Image analysis and its application is the traditional part that deals with the problem of data processing, recognition and classification. Bioinformatics has become a dynamically developed field of computer assisted biologic...

  5. Emerging technologies

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Shin-yee


    The mission of the Emerging Technologies thrust area at Lawrence Livermore National Laboratory is to help individuals establish technology areas that have national and commercial impact, and are outside the scope of the existing thrust areas. We continue to encourage innovative ideas that bring quality results to existing programs. We also take as our mission the encouragement of investment in new technology areas that are important to the economic competitiveness of this nation. In fiscal year 1992, we have focused on nine projects, summarized in this report: (1) Tire, Accident, Handling, and Roadway Safety; (2) EXTRANSYT: An Expert System for Advanced Traffic Management; (3) Odin: A High-Power, Underwater, Acoustic Transmitter for Surveillance Applications; (4) Passive Seismic Reservoir Monitoring: Signal Processing Innovations; (5) Paste Extrudable Explosive Aft Charge for Multi-Stage Munitions; (6) A Continuum Model for Reinforced Concrete at High Pressures and Strain Rates: Interim Report; (7) Benchmarking of the Criticality Evaluation Code COG; (8) Fast Algorithm for Large-Scale Consensus DNA Sequence Assembly; and (9) Using Electrical Heating to Enhance the Extraction of Volatile Organic Compounds from Soil.

  6. Interactions between microbial activity and distribution and mineral coatings on sand grains from rapid sand filters treating groundwater

    DEFF Research Database (Denmark)

    Gülay, Arda; Tatari, Karolina; Musovic, Sanin

    Rapid sand filtration is a traditional and widespread technology for drinking water purification which combines biological, chemical and physical processes together. Granular media, especially sand, is a common filter material that allows several oxidized compounds to accumulate on its surface...

  7. Wyoming Basin Rapid Ecoregional Assessment (United States)

    Carr, Natasha B.; Means, Robert E.


    The overall goal of the Wyoming Basin Rapid Ecoregional Assessment (REA) is to provide information that supports regional planning and analysis for the management of ecological resources. The REA provides an assessment of baseline ecological conditions, an evaluation of current risks from drivers of ecosystem change (including energy development, fire, and invasive species), and a predictive capacity for evaluating future risks (including climate change). Additionally, the REA may be used for identifying priority areas for conservation or restoration and for assessing cumulative effects of multiple land uses. The Wyoming Basin REA will address Management Questions developed by the Bureau of Land Management and other agency partners for 8 major biomes and 19 species or species assemblages. The maps developed for addressing Management Questions will be integrated into overall maps of landscape-level ecological values and risks. The maps can be used to address the goals of the REA at a number of levels: for individual species, species assemblages, aquatic and terrestrial systems, and for the entire ecoregion. This allows flexibility in how the products of the REA are compiled to inform planning and management actions across a broad range of spatial scales.

  8. Rapid purification of recombinant histones.

    Directory of Open Access Journals (Sweden)

    Henrike Klinker

    Full Text Available The development of methods to assemble nucleosomes from recombinant histones decades ago has transformed chromatin research. Nevertheless, nucleosome reconstitution remains time consuming to this day, not least because the four individual histones must be purified first. Here, we present a streamlined purification protocol of recombinant histones from bacteria. We termed this method "rapid histone purification" (RHP as it circumvents isolation of inclusion bodies and thereby cuts out the most time-consuming step of traditional purification protocols. Instead of inclusion body isolation, whole cell extracts are prepared under strongly denaturing conditions that directly solubilize inclusion bodies. By ion exchange chromatography, the histones are purified from the extracts. The protocol has been successfully applied to all four canonical Drosophila and human histones. RHP histones and histones that were purified from isolated inclusion bodies had similar purities. The different purification strategies also did not impact the quality of octamers reconstituted from these histones. We expect that the RHP protocol can be readily applied to the purification of canonical histones from other species as well as the numerous histone variants.

  9. Rapid Response Flood Water Mapping (United States)

    Policelli, Fritz; Brakenridge, G. R.; Coplin, A.; Bunnell, M.; Wu, L.; Habib, Shahid; Farah, H.


    Since the beginning of operation of the MODIS instrument on the NASA Terra satellite at the end of 1999, an exceptionally useful sensor and public data stream have been available for many applications including the rapid and precise characterization of terrestrial surface water changes. One practical application of such capability is the near-real time mapping of river flood inundation. We have developed a surface water mapping methodology based on using only bands 1 (620-672 nm) and 2 (841-890 nm). These are the two bands at 250 m, and the use of only these bands maximizes the resulting map detail. In this regard, most water bodies are strong absorbers of incoming solar radiation at the band 2 wavelength: it could be used alone, via a thresholding procedure, to separate water (dark, low radiance or reflectance pixels) from land (much brighter pixels) (1, 2). Some previous water mapping procedures have in fact used such single band data from this and other sensors that include similar wavelength channels. Adding the second channel of data (band 1), however, allows a band ratio approach which permits sediment-laden water, often relatively light at band 2 wavelengths, to still be discriminated, and, as well, provides some removal of error by reducing the number of cloud shadow pixels that would otherwise be misclassified as water.

  10. Machine accuracy for rapid prototyping of quality components (United States)

    Gu, Peihua; Yan, May; Huang, X.; Zhang, Xiaochen


    Ever-growing global competition forces manufacturers to deliver more competitive products with better quality, lower price and in short time. One of the most important and challenging tasks faced by value-added product manufacturing industry is substantial reduction of product development time. Rapid prototyping technologies have received significant interests from both research and industrial communities. Due to the model accuracy, integrity and strength problems, their applications are limited. The most common sources of errors in the rapid prototyping and manufacturing systems including Cubital machines can be categorized as mathematical, process-related or material- related errors. In this paper, we present an analysis of accuracy of a Cubital Solider 4600 machine and an application on pattern and mould design and manufacturing. The experimental study determines the relationships between the machine accuracy and dimensions and parameter setting, which can be used to control the accuracy of parts to be built.

  11. Rapid structural analysis of nanomaterials in aqueous solutions (United States)

    Ryuzaki, Sou; Tsutsui, Makusu; He, Yuhui; Yokota, Kazumichi; Arima, Akihide; Morikawa, Takanori; Taniguchi, Masateru; Kawai, Tomoji


    Rapid structural analysis of nanoscale matter in a liquid environment represents innovative technologies that reveal the identities and functions of biologically important molecules. However, there is currently no method with high spatio-temporal resolution that can scan individual particles in solutions to gain structural information. Here we report the development of a nanopore platform realizing quantitative structural analysis for suspended nanomaterials in solutions with a high z-axis and xy-plane spatial resolution of 35.8 ± 1.1 and 12 nm, respectively. We used a low thickness-to-diameter aspect ratio pore architecture for achieving cross sectional areas of analyte (i.e. tomograms). Combining this with multiphysics simulation methods to translate ionic current data into tomograms, we demonstrated rapid structural analysis of single polystyrene (Pst) beads and single dumbbell-like Pst beads in aqueous solutions.

  12. FY 1998 Blue Book: Computing, Information, and Communications: Technologies for the 21st Century (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — As the 21st century approaches, the rapid convergence of computing, communications, and information technology promises unprecedented opportunities for scientific...

  13. Non-calcium desulphurisation technologies

    Energy Technology Data Exchange (ETDEWEB)

    Qian Zhu [IEA Clean Coal Centre, London (United Kingdom)


    Flue gas desulphurisation (FGD) is traditionally based on limestone/lime sorbent. The majority of the installed FGD systems worldwide use limestone or lime as sorbent. However, technologies are rapidly evolving that allow desulphurisation in regions where there are limited resources of lime or limestone. These technologies provide alternatives to limestone/lime scrubbers for efficient and cost effective control of SO{sub 2} emissions from coal combustion. This report reviews the existing and emerging non-calcium based FGD processes as well as FGD technologies currently under development that apply new concepts and different approaches. It looks at the fundamentals and features of these processes, the recent technical advances and their applications in coal-fired power plants. The capital and operating costs of the processes are evaluated where information available. 66 refs., 15 figs., 10 tabs.

  14. Technological innovation in neurosurgery: a quantitative study. (United States)

    Marcus, Hani J; Hughes-Hallett, Archie; Kwasnicki, Richard M; Darzi, Ara; Yang, Guang-Zhong; Nandi, Dipankar


    Technological innovation within health care may be defined as the introduction of a new technology that initiates a change in clinical practice. Neurosurgery is a particularly technology-intensive surgical discipline, and new technologies have preceded many of the major advances in operative neurosurgical techniques. The aim of the present study was to quantitatively evaluate technological innovation in neurosurgery using patents and peer-reviewed publications as metrics of technology development and clinical translation, respectively. The authors searched a patent database for articles published between 1960 and 2010 using the Boolean search term "neurosurgeon OR neurosurgical OR neurosurgery." The top 50 performing patent codes were then grouped into technology clusters. Patent and publication growth curves were then generated for these technology clusters. A top-performing technology cluster was then selected as an exemplar for a more detailed analysis of individual patents. In all, 11,672 patents and 208,203 publications related to neurosurgery were identified. The top-performing technology clusters during these 50 years were image-guidance devices, clinical neurophysiology devices, neuromodulation devices, operating microscopes, and endoscopes. In relation to image-guidance and neuromodulation devices, the authors found a highly correlated rapid rise in the numbers of patents and publications, which suggests that these are areas of technology expansion. An in-depth analysis of neuromodulation-device patents revealed that the majority of well-performing patents were related to deep brain stimulation. Patent and publication data may be used to quantitatively evaluate technological innovation in neurosurgery.

  15. Liposome immunoassay for rapid identification of group A streptococci directly from throat swabs.


    Gerber, M. A.; Randolph, M. F.; DeMeo, K K


    The Q Test Strep (Becton Dickinson and Co., Franklin Lakes, N.J.) is a new solid-phase liposome immunoassay for the rapid diagnosis of group A beta-hemolytic streptococcal pharyngitis. Compared with blood agar plate cultures, the Q Test Strep had a sensitivity of 91%, a specificity of 83%, a positive predictive value of 88%, and a negative predictive value of 87%. Liposome technology can be used to facilitate the rapid diagnosis of group A beta-hemolytic streptococcal pharyngitis.

  16. Microbiological evaluation of a new growth-based approach for rapid detection of methicillin-resistant Staphylococcus aureus

    NARCIS (Netherlands)

    von Eiff, Christof; Maas, Dominik; Sander, Gunnar; Friedrich, Alexander W; Peters, Georg; Becker, Karsten

    OBJECTIVES: Recently, a rapid screening tool for methicillin-resistant Staphylococcus aureus (MRSA) has been introduced that applies a novel detection technology allowing the rapid presence or absence of MRSA to be determined from an enrichment broth after only a few hours of incubation. To evaluate

  17. Nanoimprint technology nanotransfer for thermoplastic and photocurable polymers

    CERN Document Server

    Taniguchi, Jun; Mizuno, Jun; Saito, Takushi


    Nanoscale pattern transfer technology using molds is a rapidly advancing area and one that has seen much recent attention due to its potential for use in nanotechnology industries and applications. However, because of these rapid advances, it can be difficult to keep up with the technological trends and the latest cutting-edge methods. In order to fully understand these pioneering technologies, a comprehensive understanding of the basic science and an overview of the techniques are required. Nanoimprint Technology: Nanotransfer for Thermoplastic and Photocurable Polymers covers

  18. Economic evaluation of medical technologies. (United States)

    Seifan, Alon; Shemer, Joshua


    Innovation in medical science is progressing at a rapid pace. As a result, new medical technologies that offer to improve upon or completely replace existing alternatives are continually appearing. These technologies--which include pharmaceuticals, devices, equipment, supplies, medical and surgical procedures, and administrative and support systems--are changing the way medicine can be practiced and delivered, forcing healthcare providers and policymakers to consistently evaluate and adapt to new treatment options. Meanwhile, society is becoming more demanding of new medical technologies. Emerging medical technology, however, has been viewed as a significant factor in increasing the cost of healthcare. The abundance of new medical alternatives, combined with scarcity of resources, has led to priority setting, rationing and the need for more technology management and assessment. Economic evaluation of medical technologies is a system of analysis used to formally compare the costs and consequences of alternative healthcare interventions. EEMT can be used by many healthcare entities, including national policymakers, manufacturers, payers and providers, as a tool to aid in resource allocation decisions. This paper discusses the four current popular methodologies for EEMT (cost-minimization, cost-benefit, cost-effectiveness and cost-utility), and describes the industry environment that has shaped their development.

  19. Health technology assessment in Finland

    DEFF Research Database (Denmark)

    Mäkelä, Marjukka; Roine, Risto P


    Since the 1990s, health policy makers in Finland have been supportive of evidence-based medicine and approaches to implement its results. The Finnish Office for Health Technology Assessment (Finohta) has grown from a small start in 1995 to a medium-sized health technology assessment (HTA) agency,...... findings. The Managed Uptake of Medical Methods program links the hospital districts to agree on introduction of technologies. The Ohtanen database provides Finnish-language summaries of major assessments made in other countries.......Since the 1990s, health policy makers in Finland have been supportive of evidence-based medicine and approaches to implement its results. The Finnish Office for Health Technology Assessment (Finohta) has grown from a small start in 1995 to a medium-sized health technology assessment (HTA) agency......, with special responsibility in providing assessments to underpin national policies in screening. External evaluations enhanced the rapid growth. In the Finnish environment, decision making on health technologies is extremely decentralized, so Finohta has developed some practical tools for implementing HTA...

  20. Risk management in information technology projects



    M.Ing. Information Technology (IT) projects are typically accompanied by a wide variety of complex risks. The rapid rate at which technology is currently changing requires the use of updated processes for project risk management in the IT industry. This paper investigates the active management of risk by focusing on the causes of such risk and developing indicators to track project risk throughout all project phases. The current research focuses on Project Risk Management as described in t...

  1. The future of monoclonal antibody technology


    Zider, Alexander; Drakeman, Donald L


    With the rapid growth of monoclonal antibody-based products, new technologies have emerged for creating modified forms of antibodies, including fragments, conjugates and multi-specific antibodies. We created a database of 450 therapeutic antibodies in development to determine which technologies and indications will constitute the “next generation” of antibody products. We conclude that the antibodies of the future will closely resemble the antibodies that have already been approved for commer...


    Slurry biodegradation systems are created by combining soil or sludge with water. This technology provides rapid biodegradation, due to enhanced mass transfer rates and increased contaminant to microorganism contact. After appropriate pretreatment, the contaminants are suspende...

  3. Prediction technologies for assessment of climate change impacts (United States)

    Temperatures, precipitation, and weather patterns are changing, in response to increasing carbon dioxide in the atmosphere. With these relatively rapid changes, existing soil erosion prediction technologies that rely upon climate stationarity are potentially becoming less reliable. This is especiall...

  4. Agreement technologies

    CERN Document Server

    Ossowski, Sascha


    More and more transactions, whether in business or related to leisure activities, are mediated automatically by computers and computer networks, and this trend is having a significant impact on the conception and design of new computer applications. The next generation of these applications will be based on software agents to which increasingly complex tasks can be delegated, and which interact with each other in sophisticated ways so as to forge agreements in the interest of their human users. The wide variety of technologies supporting this vision is the subject of this volume. It summarises

  5. Rapid thermal processing and beyond applications in semiconductor processing

    CERN Document Server

    Lerch, W


    Heat-treatment and thermal annealing are very common processing steps which have been employed during semiconductor manufacturing right from the beginning of integrated circuit technology. In order to minimize undesired diffusion, and other thermal budget-dependent effects, the trend has been to reduce the annealing time sharply by switching from standard furnace batch-processing (involving several hours or even days), to rapid thermal processing involving soaking times of just a few seconds. This transition from thermal equilibrium, to highly non-equilibrium, processing was very challenging a

  6. Individually Fitted Hearing Aid Device Manufactured Using Rapid Prototyping Based on Ear CT. A Case Report. (United States)

    Chrzan, R; Miechowicz, S; Urbanik, A; Markowska, O; Kudasik, T


    Rapid prototyping is the technology of automatic freeform fabrication of physical objects from virtual CAD (computer aided design) models. For medical objects the models may be created using data from CT, MR or rotational angiography. We descriobe the case of a 83-year-old woman with essential bilateral hearing impairment as the effect of chronic otitis media. An individually fitted hearing aid was produced for the patient using stereolithography technology and vacuum casting based on data obtained during ear CT. Rapid prototyping may help in manufacturing individually adjusted biomedical prostheses, reducing the time of device production and improving its fitting.

  7. Wearable Technology (United States)

    Watson, Amanda


    Wearable technology projects, to be useful, in the future, must be seamlessly integrated with the Flight Deck of the Future (F.F). The lab contains mockups of space vehicle cockpits, habitat living quarters, and workstations equipped with novel user interfaces. The Flight Deck of the Future is one element of the Integrated Power, Avionics, and Software (IPAS) facility, which, to a large extent, manages the F.F network and data systems. To date, integration with the Flight Deck of the Future has been limited by a lack of tools and understanding of the Flight Deck of the Future data handling systems. To remedy this problem it will be necessary to learn how data is managed in the Flight Deck of the Future and to develop tools or interfaces that enable easy integration of WEAR Lab and EV3 products into the Flight Deck of the Future mockups. This capability is critical to future prototype integration, evaluation, and demonstration. This will provide the ability for WEAR Lab products, EV3 human interface prototypes, and technologies from other JSC organizations to be evaluated and tested while in the Flight Deck of the Future. All WEAR Lab products must be integrated with the interface that will connect them to the Flight Deck of the Future. The WEAR Lab products will primarily be programmed in Arduino. Arduino will be used for the development of wearable controls and a tactile communication garment. Arduino will also be used in creating wearable methane detection and warning system.

  8. Understanding Technology?

    Directory of Open Access Journals (Sweden)

    Erik Bendtsen


    Full Text Available We are facing radical changes in our ways of living in the nearest future. Not necessarily of our own choice, but because tchnological development is moving so fast, that it will have still greater impact on many aspects of our lives. We have seen the beginnings of that change within the latest 35 years or so, but according to newest research that change will speed up immensely in the nearest years to come. The impact of that change or these changes will affect our working life immensely as a consequence of automation. How these changes are brought about and which are their consequences in a broad sense is being attempted to be understood and guessed by researchers. No one knows for sure, but specific patterns are visible. This paper will not try to guess, what will come, but will rather try to understand the deepest ”nature” of technology in order to understand the driving factors in this development: the genesis of technology in a broad sense in order to contibute to the understanding of the basis for the expected development.

  9. Friction Induced Wear of Rapid Prototyping Generated Materials: A Review

    Directory of Open Access Journals (Sweden)

    A. Tsouknidas


    Full Text Available Additive manufacturing has been introduced in the early 80s and has gained importance as a manufacturing process ever since. Even though the inception of the implicated processes predominantly focused on prototyping purposes, during the last years rapid prototyping (RP has emerged as a key enabling technology for the fabrication of highly customized, functionally gradient materials. This paper reviews friction-related wear phenomena and the corresponding deterioration mechanisms of RP-generated components as well as the potential of improving the implicated materials' wear resistance without significantly altering the process itself. The paper briefly introduces the concept of RP technologies and the implicated materials, as a premises to the process-dependent wear progression of the generated components for various degeneration scenarios (dry sliding, fretting, etc..

  10. Photon technology. Hard photon technology; Photon technology. Hard photon gijutsu

    Energy Technology Data Exchange (ETDEWEB)



    Research results of hard photon technology have been summarized as a part of novel technology development highly utilizing the quantum nature of photon. Hard photon technology refers to photon beam technologies which use photon in the 0.1 to 200 nm wavelength region. Hard photon has not been used in industry due to the lack of suitable photon sources and optical devices. However, hard photon in this wavelength region is expected to bring about innovations in such areas as ultrafine processing and material synthesis due to its atom selective reaction, inner shell excitation reaction, and spatially high resolution. Then, technological themes and possibility have been surveyed. Although there are principle proposes and their verification of individual technologies for the technologies of hard photon generation, regulation and utilization, they are still far from the practical applications. For the photon source technology, the laser diode pumped driver laser technology, laser plasma photon source technology, synchrotron radiation photon source technology, and vacuum ultraviolet photon source technology are presented. For the optical device technology, the multi-layer film technology for beam mirrors and the non-spherical lens processing technology are introduced. Also are described the reduction lithography technology, hard photon excitation process, and methods of analysis and measurement. 430 refs., 165 figs., 23 tabs.

  11. The impact of commercial rapid respiratory virus diagnostic tests on patient outcomes and health system utilization. (United States)

    Ko, Fiona; Drews, Steven J


    Acute respiratory tract infections due to influenza A/B and respiratory syncytial virus (RSV) are major causes of morbidity and mortality globally. Rapid tests for detection of these pathogens include antigen detection point of care tests (POC) and newer easy to use molecular tests. From experience, these assays improve both laboratory workflow and assay interpretation issues. However, the question of the benefits of using rapid test technology compared to routine laboratory testing for respiratory viral pathogens is still often asked. Areas covered: Specifically, this review aims to; 1) identify clinical/patient indicators that can be measured prior to and following the implementation of rapid diagnostic test for influenza and RSV, 2) provide multiple perspectives on the extent of impact of a rapid diagnostic test, including direct and indirect outcomes, and 3) identify the technological advancements in the development of rapid testing, demonstrating a timeline that transitions from antigen-based assays to molecular assays. Expert commentary: Key benefits to the use of either antigen-based or molecular rapid tests for patient care, patient flow within institutions, as well as laboratory utilization are identified. Due to improved test characteristics, the authors feel that rapid molecular tests have greater benefits than antigen-based detection methods.

  12. Rapid Automated Mission Planning System Project (United States)

    National Aeronautics and Space Administration — The proposed innovation is an automated UAS mission planning system that will rapidly identify emergency (contingency) landing sites, manage contingency routing, and...

  13. WIST: toolkit for rapid, customized LIMS development

    National Research Council Canada - National Science Library

    Huang, Y Wayne; Arkin, Adam P; Chandonia, John-Marc


    Workflow Information Storage Toolkit (WIST) is a set of application programming interfaces and web applications that allow for the rapid development of customized laboratory information management systems (LIMS...

  14. JIEDDO Experience Provides Rapid Acquisition Insights

    National Research Council Canada - National Science Library

    James P Craft


    .... JIDA's rapid acquisition capabilities were preserved by transitioning the expedient organization that received supplemental funding into the Defense Department's newest combat support agency (CSA...

  15. Architectural Technology and Technological Planning

    Directory of Open Access Journals (Sweden)

    Giorgio Giallocosta


    Full Text Available At least three fundamental aspects of the many singular technological approaches to architectural planning are currently evolving significantly and are ripe for potential development. The first relates to enhanced opportunities for defining the ex-ante characteristics and performance of building products and components, but particularly concerns potential leadership assumptions in planning and the ‘reification’ of architecture through ‘collective’ behaviours. The second relates to the tendency to try and overcome the connotation of architectural projects, inclusive of their entire life cycle. The third relates to current evolutionary developments (either potential or simply implicit in performance approach.

  16. Leveraging the Habit-Forming Aspects of Technology to Increase Levels of Physical Activity (United States)

    Rotich, Willy Kipkemboi


    The use of technology to promote physical activity has been rapidly gaining popularity as technological advances find ever-broadening applications. Though some technology aspects (i.e., on-screen video games) were for long perceived to be incompatible with efforts to diminish physical inactivity, evolving technology has made incorporating newer…

  17. Technology transfer? The rise of China and India in green technology sectors

    DEFF Research Database (Denmark)

    Lema, Rasmus; Lema, Adrian


    for these countries? This paper seeks insights from three green technology sectors in both countries: wind power, solar energy and electric and hybrid vehicles. We find that, conventional technology transfer mechanisms such as foreign direct investments and licensing, were important for industry formation and take......International technology transfer is central to the debate about how to curb the carbon emissions from rapid economic growth in China and India. But given China and India's great progress in building innovation capabilities and green industries, how relevant is technology transfer...

  18. Incineration technologies

    CERN Document Server

    Buekens, Alfons


    Waste incineration is the art of completely combusting waste, while maintaining or reducing emission levels below current emission standards. Where possible, objectives include the recovering of energy as well as the  combustion residues.  Successful waste incineration makes it possible to achieve a deep reduction in waste volume, obtain a compact and sterile residue, and eliminate a wide array of pollutants. This book places waste incineration within the wider context of waste management, and demonstrates that, in contrast to landfills and composting, waste incineration can eliminate objectionable and hazardous properties such as flammability and toxicity, result in a significant reduction in volume, and destroy gaseous and liquid waste streams leaving little or no residues beyond those linked to flue gas neutralization and treatment. Moreover, waste incineration sterilizes and destroys putrescible matter, and produces usable heat.  Incineration Technologies first appeared as a peer-reviewed contribution ...

  19. The incidence of technological stress among baccalaureate nurse educators using technology during course preparation and delivery. (United States)

    Burke, Mary S


    The concept of technology-related stress was first introduced in the 1980s when computers became more prevalent in the business and academic world. Nurse educators have been impacted by the rapid changes in technology in recent years. A review of the literature revealed no research studies that have been conducted to investigate the incidence of technological stress among nurse educators. The purpose of this descriptive-correlational study was to describe the technological stressors that Louisiana baccalaureate nurse educators experienced while teaching nursing theory courses. A researcher-developed questionnaire, the nurse educator technostress scale (NETS) was administered to a census sample of 311 baccalaureate nurse educators in Louisiana. Findings revealed that Louisiana baccalaureate nurse educators are experiencing technological stress. The variable, perceived administrative support for use of technology in the classroom, was a significant predictor in a regression model predicting Louisiana baccalaureate nurse educators' technological stress (F=14.157, p<.001).

  20. Lander Technologies (United States)

    Chavers, Greg


    Since 2006 NASA has been formulating robotic missions to the lunar surface through programs and projects like the Robotic Lunar Exploration Program, Lunar Precursor Robotic Program, and International Lunar Network. All of these were led by NASA Marshall Space Flight Center (MSFC). Due to funding shortfalls, the lunar missions associated with these efforts, the designs, were not completed. From 2010 to 2013, the Robotic Lunar Lander Development Activity was funded by the Science Mission Directorate (SMD) to develop technologies that would enable and enhance robotic lunar surface missions at lower costs. In 2013, a requirements-driven, low-cost robotic lunar lander concept was developed for the Resource Prospector Mission. Beginning in 2014, The Advanced Exploration Systems funded the lander team and established the MSFC, Johnson Space Center, Applied Physics Laboratory, and the Jet Propulsion Laboratory team with MSFC leading the project. The lander concept to place a 300-kg rover on the lunar surface has been described in the New Technology Report Case Number MFS-33238-1. A low-cost lander concept for placing a robotic payload on the lunar surface is shown in figures 1 and 2. The NASA lander team has developed several lander concepts using common hardware and software to allow the lander to be configured for a specific mission need. In addition, the team began to transition lander expertise to United States (U.S.) industry to encourage the commercialization of space, specifically the lunar surface. The Lunar Cargo Transportation and Landing by Soft Touchdown (CATALYST) initiative was started and the NASA lander team listed above is partnering with three competitively selected U.S. companies (Astrobotic, Masten Space Systems, and Moon Express) to develop, test, and operate their lunar landers.

  1. A Progressive Approach to Integrating Education Technology (United States)

    Nemcek, Felicia


    Do you ever have the feeling that with rapidly changing technology your students are driving the bus and you are holding on for dear life? According to the author, who is the principal of the Southwest Career and Technical Academy (SWCTA) located in Las Vegas, Nevada, they feel that way more often than not. However, she and her faculty understand…

  2. Management of e-technology in China

    NARCIS (Netherlands)

    Wei, Y.; de Boer, S.J.; Chen, Jin; Kocaoglu, D.F.; Anderson, T.R.


    "e" technology is bringing about many challenges for companies, in particular for their managers. This concerns a vast range of business processes in many sectors of the economy and in nearly every country of the world. In rapidly industrializing China, companies and other organizations are actively

  3. Policy processes and health technology assessment

    NARCIS (Netherlands)

    Palmhøj Nielsen, Camilla; Sarriá Santamera, Antonio; Vondeling, Hindrik


    Decision-makers throughout Europe have a common goal of raising health standards in order to improve the health status of the European population. Health service delivery is carried out under conditions of growing political and economic complexity – rapid technological change puts pressure on

  4. The Design of Large Technological Systems

    DEFF Research Database (Denmark)

    Pineda, Andres Felipe Valderrama

    This is a study of the processes of design of large technological systems based on a two-case study: the rapid transit bus system, Transmilenio, in Bogotá, Colombia, and the urban rail system, Metro, in Copenhagen, Denmark. The research focused especially on the process by which designers define...

  5. Educational Technology Research in a VUCA World (United States)

    Reeves, Thomas C.; Reeves, Patricia M.


    The status of educational technology research in a VUCA world is examined. The acronym, VUCA, stands for "Volatility" (rapidly changing contexts and conditions), "Uncertainty" (information missing that is critical to problem solving), "Complexity" (multiple factors difficult to categorize or control), and…

  6. Algal blooms and Membrane Based Desalination Technology

    NARCIS (Netherlands)

    Villacorte, L.O.


    Seawater desalination is rapidly growing in terms of installed capacity (~80 million m3/day in 2013), plant size and global application. An emerging threat to this technology is the seasonal proliferation of microscopic algae in seawater known as algal blooms. Such blooms have caused operational

  7. Present challenges of research and technology politics (United States)

    Bulow, A. V.


    Research and technology in Germany are discussed. The rapid transfer of scientific knowledge and techniques from the laboratory to the manufacturing and industrial communities is identified as a priority. It is recommended that the government give maximum support to the aviation and space flight industries.

  8. Assessing information and communication technology in surgical ...

    African Journals Online (AJOL)


    Aug 3, 2012 ... of these computer-based technology tools are clear but they are expensive, may not be available and there is ... d. identify obstacles to IT use in surgical education. The rapid development of IT has dramatically ... teaching and problem based learning (2, 9). Despite progress in surgical training, a number of ...


    African Journals Online (AJOL)

    The World Health Organization recognizes the need for new, affordable, rapid and highly sensitive diagnostics for use in developing countries. Phage amplification technology employs a specific mycobacteriophage which infects a live TB bacillus if represent in a sample. These replicate and lyse the cells to release progeny ...

  10. African Journal of Environmental Science and Technology ...

    African Journals Online (AJOL)

    African Journal of Environmental Science and Technology (ISSN 1996-0786) is an open access journal that provides rapid publication (monthly) of articles in all areas of the subject. The Journal welcomes the submission ... both sections can be combined. The Acknowledgments of people, grants, funds, etc should be brief.

  11. African Journal of Environmental Science and Technology

    African Journals Online (AJOL)

    African Journal of Environmental Science and Technology (AJEST) is an open access journal that provides rapid publication (monthly) of articles in all areas of the subject. ... Biosorption of fluoride ion from water using the seeds of the cabbage tree (Moringa stenopetala) · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  12. Mn3O4 nano-sized crystals: Rapid synthesis and extension to ...

    Indian Academy of Sciences (India)

    Mn3O4 nano-sized crystals: Rapid synthesis and extension to preparation of nanosized LiMn2O4 materials. XIAO-LING CUI, YONG-LI LI, SHI-YOU LI. ∗. , GUO-CUN SUN, JIN-XIA MA,. LU ZHANG, TIAN-MING LI and RONG-BO MA. College of Petrochemical Technology, Lanzhou University of Technology, Lanzhou 730050, ...

  13. Test plan for the Rapid Geophysical Surveyor

    Energy Technology Data Exchange (ETDEWEB)

    Roybal, L.G.


    This document describes the test plant for demonstrating and testing a set of optically pumped cesium-based total field magnetometers using the Rapid Geophysical Surveyor platform. The proposed testing will be used to assess the function of these magnetometers as deployed on the Rapid Geophysical Surveyor and evaluate the practical utility of high resolution magnetic data for supporting waste retrieval efforts.

  14. Rapid eye movement sleep behavior disorder

    DEFF Research Database (Denmark)

    Schenck, C H; Montplaisir, J Y; Frauscher, B


    We aimed to provide a consensus statement by the International Rapid Eye Movement Sleep Behavior Disorder Study Group (IRBD-SG) on devising controlled active treatment studies in rapid eye movement sleep behavior disorder (RBD) and devising studies of neuroprotection against Parkinson disease (PD...

  15. Rapid Prototyping of Mobile Learning Games (United States)

    Federley, Maija; Sorsa, Timo; Paavilainen, Janne; Boissonnier, Kimo; Seisto, Anu


    This position paper presents the first results of an on-going project, in which we explore rapid prototyping method to efficiently produce digital learning solutions that are commercially viable. In this first phase, rapid game prototyping and an iterative approach was tested as a quick and efficient way to create learning games and to evaluate…

  16. Rapid methods for detection of bacteria

    DEFF Research Database (Denmark)

    Corfitzen, Charlotte B.; Andersen, B.Ø.; Miller, M.


    Traditional methods for detection of bacteria in drinking water e.g. Heterotrophic Plate Counts (HPC) or Most Probable Number (MNP) take 48-72 hours to give the result. New rapid methods for detection of bacteria are needed to protect the consumers against contaminations. Two rapid methods...

  17. Mobile biometric device (MBD) technology :

    Energy Technology Data Exchange (ETDEWEB)

    Aldridge, Chris D.


    Mobile biometric devices (MBDs) capable of both enrolling individuals in databases and performing identification checks of subjects in the field are seen as an important capability for military, law enforcement, and homeland security operations. The technology is advancing rapidly. The Department of Homeland Security Science and Technology Directorate through an Interagency Agreement with Sandia sponsored a series of pilot projects to obtain information for the first responder law enforcement community on further identification of requirements for mobile biometric device technology. Working with 62 different jurisdictions, including components of the Department of Homeland Security, Sandia delivered a series of reports on user operation of state-of-the-art mobile biometric devices. These reports included feedback information on MBD usage in both operational and exercise scenarios. The findings and conclusions of the project address both the limitations and possibilities of MBD technology to improve operations. Evidence of these possibilities can be found in the adoption of this technology by many agencies today and the cooperation of several law enforcement agencies in both participating in the pilot efforts and sharing of information about their own experiences in efforts undertaken separately.

  18. Porous Ti6Al4V scaffold directly fabricating by rapid prototyping: preparation and in vitro experiment

    NARCIS (Netherlands)

    Li Jiaping, L.; de Wijn, J.R.; van Blitterswijk, Clemens; de Groot, K.


    Three-dimensional (3D) fiber deposition (3DF), a rapid prototyping technology, was successfully directly applied to produce novel 3D porous Ti6Al4V scaffolds with fully interconnected porous networks and highly controllable porosity and pore size. A key feature of this technology is the 3D

  19. Applications of aerospace technology in industry: A technology transfer profile. Visual display systems (United States)


    The growth of common as well as emerging visual display technologies are surveyed. The major inference is that contemporary society is rapidly growing evermore reliant on visual display for a variety of purposes. Because of its unique mission requirements, the National Aeronautics and Space Administration has contributed in an important and specific way to the growth of visual display technology. These contributions are characterized by the use of computer-driven visual displays to provide an enormous amount of information concisely, rapidly and accurately.

  20. Technology for Educational Change (United States)

    Mitchell, P. David


    Five fundamental manifestations of technology for educational change are examined with particular reference to Canadian activities. These foci are: psychotechnology, information and communications technology, organizational technology, cybernetic systems technology and educational planning. Each is vitally concerned with the optimal organization…

  1. Networking Technologies and the Rate of Technological Change

    Directory of Open Access Journals (Sweden)

    Charles Mitchell


    Full Text Available Network technology is changing rapidly and those adept at ICT analysis need resolve rate of change issues. Developments in networking now are in the direction of heuristic intelligence. Since about 1980, networking techniques have encouraged combining bits of information with imagination cognitively to improve ideas about reality. ICT enterprise projects utilize networking to sustain requisite imagination. Assumptions and misassuptions of project builders are rationally comprehended as networking sustains creative processes. The monopolization of valuable network techniques influences in the direction of esoteric networking. Data presents that substantial knowledge and networking is now occurring globally. As a netaphor, networking

  2. Hi'iaka: Haumea's Rapidly Spinning Moon (United States)

    Kohler, Susanna


    An image from the Keck telescope of the dwarf planet Haumea (center) and its two moons, Hiiaka (above) and Namaka (below). [Caltech/Keck/Mike Brown]Recent observations of Hiiaka, the largest satellite of the dwarf planet Haumea, reveal that the moon is spinning much more rapidly than expected. What could this tell us about how Haumea and its moons formed?A Distant DwarfThe dwarf planet Haumea orbits beyond Neptune and has a mass of roughly 1/3 that of Pluto. Like Pluto, Haumea also has companions: two satellites of roughly 0.5% and 0.05% of Haumeas mass, orbiting at rather large distances of 36 and 70 Haumea radii (roughly 26,000 and 50,000 km).In a recently published study, a team led by Danielle Hastings (UC Los Angeles and Florida Institute of Technology) explored Hubble and Magellan observations of Hiiaka Haumeas larger, outer satellite to determine the rate at which it rotates on its axis.Hiiakas light curve, phase-folded at its most likely rotation period of 9.8 hours. The double peak is due to the fact that Hiiaka is likely not a spherical body, so it shows two maxima in brightness in each full rotation. [Hastings et al. 2016]Rapid RotationNominally, wed expect Hiiaka to be rotating synchronously its rotation period should be the same as its orbital period of 49.5 days. We expect this because the amount of time needed for tidal forces to despin Hiiaka to synchronous rotation should be much shorter than the time needed for these forces to produce Hiiakas observed low eccentricity and large semimajor axis.Therefore it was quite the surprise when Hastings and collaborators analyzed Hiiakas light curve and found that the moon revolves on its axis once every 9.8 hours! Thats roughly 120 times faster than the expected synchronous rate.Formation TheoriesWhat does this discovery reveal about Hiiakas formation? Hastings and collaborators propose three possible scenarios. They then use analytic calculations and numerical simulations to try to constrain them based on

  3. How Technology Teachers Understand Technological Knowledge (United States)

    Norström, Per


    Swedish technology teachers' views of technological knowledge are examined through a written survey and a series of interviews. The study indicates that technology teachers' understandings of what constitutes technological knowledge and how it is justified vary considerably. The philosophical discussions on the topic are unknown to them. This lack…

  4. Analysis of the frontier technology of agricultural IoT and its predication research (United States)

    Han, Shuqing; Zhang, Jianhua; Zhu, Mengshuai; Wu, Jianzhai; Shen, Chen; Kong, Fantao


    Agricultural IoT (Internet of Things) develops rapidly. Nanotechnology, biotechnology and optoelectronic technology are successfully integrated into the agricultural sensor technology. Big data, cloud computing and artificial intelligence technology have also been successfully used in IoT. This paper carries out the research on integration of agricultural sensor technology, nanotechnology, biotechnology and optoelectronic technology and the application of big data, cloud computing and artificial intelligence technology in agricultural IoT. The advantages and development of the integration of nanotechnology, biotechnology and optoelectronic technology with agricultural sensor technology were discussed. The application of big data, cloud computing and artificial intelligence technology in IoT and their development trend were analysed.

  5. A rapid protection switching method in carrier ethernet ring networks (United States)

    Yuan, Liang; Ji, Meng


    Abstract: Ethernet is the most important Local Area Network (LAN) technology since more than 90% data traffic in access layer is carried on Ethernet. From 10M to 10G, the improving Ethernet technology can be not only used in LAN, but also a good choice for MAN even WAN. MAN are always constructed in ring topology because the ring network could provide resilient path protection by using less resource (fibre or cable) than other network topologies. In layer 2 data networks, spanning tree protocol (STP) is always used to protect transmit link and preventing the formation of logic loop in networks. However, STP cannot guarantee the efficiency of service convergence when link fault happened. In fact, convergent time of networks with STP is about several minutes. Though Rapid Spanning Tree Protocol (RSTP) and Multi-Spanning Tree Protocol (MSTP) improve the STP technology, they still need a couple of seconds to achieve convergence, and can not provide sub-50ms protection switching. This paper presents a novel rapid ring protection method (RRPM) for carrier Ethernet. Unlike other link-fault detection method, it adopts distributed algorithm to detect link fault rapidly (sub-50ms). When networks restore from link fault, it can revert to the original working state. RRPM can provide single ring protection and interconnected ring protection without the formation of super loop. In normal operation, the master node blocks the secondary port for all non-RRPM Ethernet frames belonging to the given RRPM Ring, thereby avoiding a loop in the ring. When link fault happens, the node on which the failure happens moves from the "ring normal" state to the "ring fault" state. It also sends "link down" frame immediately to other nodes and blocks broken port and flushes its forwarding database. Those who receive "link down" frame will flush forwarding database and master node should unblock its secondary port. When the failure restores, the whole ring will revert to the normal state. That is

  6. Electricity Storage. Technology Brief

    Energy Technology Data Exchange (ETDEWEB)

    Simbolotti, G. [Italian National Agency for New Technologies, Energy and Sustainable Economic Development ENEA, Rome (Italy); Kempener, R. [International Renewable Energy Agency IRENA, Bonn (Germany)


    Electricity storage is a key technology for electricity systems with a high share of renewables as it allows electricity to be generated when renewable sources (i.e. wind, sunlight) are available and to be consumed on demand. It is expected that the increasing price of fossil fuels and peak-load electricity and the growing share of renewables will result in electricity storage to grow rapidly and become more cost effective. However, electricity storage is technically challenging because electricity can only be stored after conversion into other forms of energy, and this involves expensive equipment and energy losses. At present, the only commercial storage option is pumped hydro power where surplus electricity (e.g. electricity produced overnight by base-load coal or nuclear power) is used to pump water from a lower to an upper reservoir. The stored energy is then used to produce hydropower during daily high-demand periods. Pumped hydro plants are large-scale storage systems with a typical efficiency between 70% and 80%, which means that a quarter of the energy is lost in the process. Other storage technologies with different characteristics (i.e. storage process and capacity, conversion back to electricity and response to power demand, energy losses and costs) are currently in demonstration or pre-commercial stages and discussed in this brief report: Compressed air energy storage (CAES) systems, Flywheels; Electrical batteries; Supercapacitors; Superconducting magnetic storage; and Thermal energy storage. No single electricity storage technology scores high in all dimensions. The technology of choice often depends on the size of the system, the specific service, the electricity sources and the marginal cost of peak electricity. Pumped hydro currently accounts for 95% of the global storage capacity and still offers a considerable expansion potential but does not suit residential or small-size applications. CAES expansion is limited due to the lack of suitable

  7. The Technology Crisis in Neuropsychology. (United States)

    Miller, Justin B; Barr, William B


    Neuropsychology has fallen reliant on outdated and labor intensive methods of data collection that are slow, highly inefficient, and expensive, and provide relatively data-poor estimates of human behavior despite rapid technological advance in most other fields of medicine. Here we present a brief historical overview of current testing practices in an effort to frame the current crisis, followed by an overview of different settings in which technology can and should be integrated. Potential benefits of laboratory based assessments, remote assessments, as well as passive and high-frequency data collection tools rooted in technology are discussed, along with several relevant examples and how these technologies might be deployed. Broader issues of data security and privacy are discussed, as well as additional considerations to be addressed within each setting. Some of the historical barriers to adoption of technology are also presented, along with a brief discussion of the remaining uncertainties. While by no means intended as a comprehensive review or prescriptive roadmap, our goal is to show that there are a tremendous number of advantages to technologically driven data collection methods, and that technology should be embraced by the field. Our predictions are that the comprehensive assessments of the future will likely entail a combination of lab-based assessments, remote assessments, and passive data capture, and leading the development of these efforts will cement the role of neuropsychology at the forefront of cognitive and behavioral science. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail:

  8. Fiscal 2000 regional consortium research and development project - regional new technology creation research and development. Massive rapid identification of gene functions; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo - chiiki shingijutsu soshutsu kenkyu kaihatsu seika hokokusho. Idenshi kino no tairyo jinsoku dotei ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)



    Efforts are exerted to develop a system for massive and rapid identification of unknown genes through the utilization of techniques based on the unusual membrane fusion characteristics of HVJ (hemagglutinating virus of Japan), which enables the introduction of genes efficiently and uniformly into cultured cells and living organs (development into a kit). Activities are conducted in the three fields of (1) the development of a method for introducing genes using an HVJ envelop vector, (2) a survey of kit marketing and cold storage facilities in the selling and distribution of the kit, and (3) a comprehensive survey. In the field of (1), studies are conducted for the establishment of methods for HVJ envelop vector production and refining, the establishment of an optimized method for encapsulating genes into the HVJ envelop vector, and the introduction of genes into cultured central neurons using the HVJ envelop vector system. A refining method has been established, which comprises the inoculation of HVJ into eggs, 4-day culture, egg cutting, liquid sampling (chorioallantoic liquid), inactivation (addition of alkylating agent), filtration, enrichment (ultrafiltration), and an anion exchange chromatogram. (NEDO)

  9. Technology diversification, product innovations, and technology transfer


    Woerter, Martin


    This paper investigates the relationship between technology specialization and innovation performance of firms emphasizing technology transfer activities with universities as an important knowledge source in order to attenuate the opportunity costs of technological specialization. Based on an econometric analysis combining patent data and survey data on technology transfer activities of firms it was found that technology transfer is positively related with the sales share of innovative produc...

  10. Technological capabilities, technological dynamism and innovation offshoring


    Schubert, Torben; Baier, Elisabeth; Rammer, Christian


    In this paper we analyze the conditions under which firms decide to offshore innovation. We consider the role of internal technological capabilities and technological dynamism in the firm environment, distinguishing speed and uncertainty of technological change. Using unique data from the German Innovation Survey we find that while high speed of technological change tends to drive innovation offshoring, high uncertainty about future technology developments results in more innovation offsho...

  11. Rapid detection, characterization, and enumeration of foodborne pathogens. (United States)

    Hoorfar, J


    As food safety management further develops, microbiological testing will continue to play an important role in assessing whether Food Safety Objectives are achieved. However, traditional microbiological culture-based methods are limited, particularly in their ability to provide timely data. The present review discusses the reasons for the increasing interest in rapid methods, current developments in the field, the research needs, and the future trends. The advent of biotechnology has introduced new technologies that led to the emergence of rapid diagnostic methods and altered food testing practices. Rapid methods are comprised of many different detection technologies, including specialized enzyme substrates, antibodies and DNA, ranging from simple differential plating media to the use of sophisticated instruments. The use of non-invasive sampling techniques for live animals especially came into focus with the 1990s outbreak of bovine spongiform encephalopathy that was linked to the human outbreak of Creutzfeldt Jakob's Disease. Serology is still an important tool in preventing foodborne pathogens to enter the human food supply through meat and milk from animals. One of the primary uses of rapid methods is for fast screening of large number of samples, where most of them are expected to be test-negative, leading to faster product release for sale. This has been the main strength of rapid methods such as real-time Polymerase Chain Reaction (PCR). Enrichment PCR, where a primary culture broth is tested in PCR, is the most common approach in rapid testing. Recent reports show that it is possible both to enrich a sample and enumerate by pathogen-specific real-time PCR, if the enrichment time is short. This can be especially useful in situations where food producers ask for the level of pathogen in a contaminated product. Another key issue is automation, where the key drivers are miniaturization and multiple testing, which mean that not only one instrument is flexible

  12. The Roles of Research Universities in Indigenous National Technological Innovation (United States)

    Feng, Zhuolin; Zhao, Wenhua


    The world is increasingly merged into a global market economy, and the government's intervention power in economy has rapidly given way to that of science and technology. For the world's major economic powers, indigenous technological innovation has become a national strategy for enhancing competitiveness. Investment in scientific and…

  13. Changing Technologies Offer New Opportunities in the Plant Sciences

    Directory of Open Access Journals (Sweden)

    Theresa M. Culley


    Full Text Available The plant sciences are now facing an unprecedented time in our history in which technology is advancing at a rapid pace, creating a wide variety of novel opportunities for our field. Applications in Plant Sciences is a new source for sharing exciting and innovative applications of new technologies that have the potential to propel plant research forward into the future.

  14. History, Communications and Some Further Perils of Technology. (United States)

    Feldman, Marvin

    Presented to the faculty of the Fashion Institute of Technology (New York City) after the acceptance by the New York Board of Regents of the school's plan to offer master's degree programs, these remarks focus on the problems presented by rapid developments in communications technology and the responsibility of the faculty to participate in the…

  15. A Virtual Education: Guidelines for Using Games Technology (United States)

    Schofield, Damian


    Advanced three-dimensional virtual environment technology, similar to that used by the film and computer games industry, can allow educational developers to rapidly create realistic online vir-tual environments. This technology has been used to generate a range of interactive Virtual Real-ity (VR) learning environments across a spectrum of…

  16. Enterprise Information Technology Organizational Flexibility: Managing Uncertainty and Change (United States)

    Patten, Karen Prast


    Chief Information Officers (CIOs) lead enterprise information technology organizations (EITOs) in today's dynamic competitive business environment. CIOs deal with external and internal environmental changes, changing internal customer needs, and rapidly changing technology. New models for the organization include flexibility and suggest that CIOs…

  17. Does Your Department Have a Technology Innovation Strategy? (United States)

    Felkey, Bill G; Fox, Brent I


    There are ways to facilitate the successful implementation of technological innovations. These are especially important in a time of rapid development of new tools to support safe and effective medication therapy. This installment addresses some of the key components of a successful technology innovation strategy.

  18. Mobile technology for health care in rural China

    Directory of Open Access Journals (Sweden)

    Zhao Ni


    Full Text Available With the proliferation of mobile technologies in China, the Chinese mobile medical applications market is growing rapidly. This may be particularly useful for Chinese rural populations who have limited access to quality medical care where mobile technologies can reach across geographic and socioeconomic boundaries and potentially increase access to care and improve health outcomes.

  19. Emerging methods, technologies and process management in software engineering

    CERN Document Server

    Ferrucci, Filomena; Tortora, Genny; Tucci, Maurizio


    A high-level introduction to new technologies andmethods in the field of software engineering Recent years have witnessed rapid evolution of software engineering methodologies, and until now, there has been no single-source introduction to emerging technologies in the field.

  20. Students' Attitudes toward Gene Technology: Deconstructing a Construct (United States)

    Gardner, Grant E.; Troelstrup, Angelique


    Emergent technologies are commonly characterized as involving cutting-edge developments while lacking wide-scale public implementation. Although currently prevalent in many applications, gene technology is often considered emergent in that the science changes so rapidly. Science educators at all levels of formal education are faced with a unique…

  1. The Future of Mobile Technology and Mobile Wireless Computing (United States)

    Hart, Jim; Hannan, Mike


    It is often stated that mobile wireless computing is going to be the next big technology revolution that will grip the world in the same way mobile telephones did in the 1990s. However, while the technology is rapidly improving, the rate of uptake has been lower than expected. This paper describes some of the reasons for this, and discusses some…

  2. Emerging technologies in engineering education: can we make it work?

    NARCIS (Netherlands)

    Klaassen, R.G.; de Vries, P.; Kamp, A.


    This paper deals with an explorative research into the use of emerging technologies for teaching and learning. An important stimulus for this research is the skills gap. The rapid changing demand puts a lot of pressure on education and the promise is that technology might help to solve the problem.

  3. Technology for People, Not Disabilities: Ensuring Access and Inclusion (United States)

    Foley, Alan; Ferri, Beth A.


    The potential of technology to connect people and provide access to education, commerce, employment and entertainment has never been greater or more rapidly changing. Communication technologies and new media promise to "revolutionize our lives" by breaking down barriers and expanding access for disabled people. Yet, it is also true that technology…

  4. Management, Security, and Congressional Oversight. Federal Government Information Technology. (United States)

    Congress of the U.S., Washington, DC. Office of Technology Assessment.

    This report considers the management, use, and congressional oversight of information technology in the Federal Government as rapid advances in technology--e.g., microcomputers, computer networking, computer modeling, videoconferencing, and electronic information exchange--are generating many new applications, opportunities, and issues which are…

  5. LEDs: DOE Programs Add Credibility to a Developing Technology (United States)

    Conbere, Susan


    LED (light-emitting diode) technology is moving fast, and with justification, some facility managers have viewed it with a wary eye. Some LEDs on the market do not perform as promised, and the technology is changing rapidly. But new developments from the U.S. Department of Energy (DOE) now make it easier for facility managers to find LEDs that…

  6. Values and Principles Guiding Technology Decision Making for the Future. (United States)

    Komives, Susan R.; Petersen, Rodney J.


    Explores several salient technological trends with implications for student affairs practitioners. Claims that student affairs personnel must become experts at understanding how rapid changes in technology affect human development, relationships, and learning. Concludes with principles that might be used to guide the choices and decisions to be…

  7. A new method for rapid Canine retraction

    Directory of Open Access Journals (Sweden)

    "Khavari A


    Full Text Available Distraction osteogenesis method (Do in bone lengthening and rapid midpalatal expansion have shown the great ability of osteognic tissues for rapid bone formation under distraction force and special protocol with optimum rate of one millimeter per day. Periodontal membrane of teeth (PDM is the extension of periostium in the alveolar socked. Orthodontic force distracts PDM fibers in the tension side and then bone formation will begin.Objects: Rapid retraction of canine tooth into extraction space of first premolar by DO protocol in order to show the ability of the PDM in rapid bone formation. The other objective was reducing total orthodontic treatment time of extraction cases.Patients and Methods: Tweleve maxillary canines in six patients were retracted rapidly in three weeks by a custom-made tooth-born appliance. Radiographic records were taken to evaluate the effects of heavy applied force on canine and anchorage teeth.Results: Average retraction was 7.05 mm in three weeks (2.35 mm/week. Canines rotated distal- in by mean 3.5 degrees.Anchorage loss was from 0 to 0.8 mm with average of 0.3 mm.Root resorption of canines was negligible, and was not significant clinically. Periodontium was normal after rapid retraction. No hazard for pulp vitality was observed.Discussion: PDM responded well to heavy distraction force by Do protocol. Rapid canine retraction seems to be a safe method and can considerabely reduce orthodontic time.

  8. Risks and Benefits of Rapid Clozapine Titration. (United States)

    Lochhead, Jeannie D; Nelson, Michele A; Schneider, Alan L


    Clozapine is often considered the gold standard for the treatment of schizophrenia. Clinical guidelines suggest a gradual titration over 2 weeks to reduce the risks of adverse events such as seizures, hypotension, agranulocytosis, and myocarditis. The slow titration often delays time to therapeutic response. This raises the question of whether, in some patients, it may be safe to use a more rapid clozapine titration. The following case illustrates the potential risks associated with the use of multiple antipsychotics and rapid clozapine titration. We present the case of a young man with schizophrenia who developed life threatening neuroleptic malignant syndrome (NMS) during rapid clozapine titration and treatment with multiple antipsychotics. We were unable to find another case in the literature of NMS associated with rapid clozapine titration. This case is meant to urge clinicians to carefully evaluate the risks and benefits of rapid clozapine titration, and to encourage researchers to further evaluate the safety of rapid clozapine titration. Rapid clozapine titration has implications for decreasing health care costs associated with prolonged hospitalizations, and decreasing the emotional suffering associated with uncontrolled symptoms of psychosis. Clozapine is considered the most effective antipsychotic available thus efforts should focus on developing strategies that would allow for safest and most efficient use of clozapine to encourage its utilization for treatment resistance schizophrenia.

  9. Risks and benefits of rapid clozapine titration

    Directory of Open Access Journals (Sweden)

    Jeannie D. Lochhead


    Full Text Available Clozapine is often considered the gold standard for the treatment of schizophrenia. Clinical guidelines suggest a gradual titration over 2 weeks to reduce the risks of adverse events such as seizures, hypotension, agranulocytosis, and myocarditis. The slow titration often delays time to therapeutic response. This raises the question of whether, in some patients, it may be safe to use a more rapid clozapine titration. The following case illustrates the potential risks associated with the use of multiple antipsychotics and rapid clozapine titration. We present the case of a young man with schizophrenia who developed life threatening neuroleptic malignant syndrome (NMS during rapid clozapine titration and treatment with multiple antipsychotics. We were unable to find another case in the literature of NMS associated with rapid clozapine titration. This case is meant to urge clinicians to carefully evaluate the risks and benefits of rapid clozapine titration, and to encourage researchers to further evaluate the safety of rapid clozapine titration. Rapid clozapine titration has implications for decreasing health care costs associated with prolonged hospitalizations, and decreasing the emotional suffering associated with uncontrolled symptoms of psychosis. Clozapine is considered the most effective antipsychotic available thus efforts should focus on developing strategies that would allow for safest and most efficient use of clozapine to encourage its utilization for treatment resistance schizophrenia.

  10. Evolution of Indoor Positioning Technologies: A Survey

    Directory of Open Access Journals (Sweden)

    Ramon F. Brena


    Full Text Available Indoor positioning systems (IPS use sensors and communication technologies to locate objects in indoor environments. IPS are attracting scientific and enterprise interest because there is a big market opportunity for applying these technologies. There are many previous surveys on indoor positioning systems; however, most of them lack a solid classification scheme that would structurally map a wide field such as IPS, or omit several key technologies or have a limited perspective; finally, surveys rapidly become obsolete in an area as dynamic as IPS. The goal of this paper is to provide a technological perspective of indoor positioning systems, comprising a wide range of technologies and approaches. Further, we classify the existing approaches in a structure in order to guide the review and discussion of the different approaches. Finally, we present a comparison of indoor positioning approaches and present the evolution and trends that we foresee.

  11. Innovative Technology Development Program. Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    Beller, J.


    Through the Office of Technology Development (OTD), the U.S. Department of Energy (DOE) has initiated a national applied research, development, demonstration, testing, and evaluation program, whose goal has been to resolve the major technical issues and rapidly advance technologies for environmental restoration and waste management. The Innovative Technology Development (ITD) Program was established as a part of the DOE, Research, Development, Demonstration, Testing, and Evaluation (RDDT&E) Program. The plan is part of the DOE`s program to restore sites impacted by weapons production and to upgrade future waste management operations. On July 10, 1990, DOE issued a Program Research and Development Announcement (PRDA) through the Idaho Operations Office to solicit private sector help in developing innovative technologies to support DOE`s clean-up goals. This report presents summaries of each of the seven projects, which developed and tested the technologies proposed by the seven private contractors selected through the PRDA process.

  12. Flywheel Technology (United States)

    Ritchie, Lisa M.


    Throughout the summer of 2004, I am working on a number of different projects. While located in the Space Power and Propulsion Test Engineering branch, my main area of study is flywheel technology. I have been exposed to flywheels, their components, and their uses in today's society. I have been able to experience numerous flywheels here in the flywheel lab at NASA Glenn. My first main project was to explore the attributes and physical characteristics of a flywheel. Our branch was constructing a flywheel demonstration to be presented at the public open house taking place in June. Our Flywheel Interactive Demo, or FIDO, represents a real life multi-flywheel system here at NASA. I was given the opportunity to learn about how these flywheels store energy and are able to position a satellite. With all of this new knowledge, I was able to create the posters that explained how our demonstration worked. I also composed a step-by-step process made up of four experiments that any visitor could follow and perform on FIDO. By stepping through these experiments, the individual learns how a flywheel works. They not only read the explanation of what is happening, but they are also able to see it happen. Creating these two posters not only taught me, but also helped teach the general public during the open house, how flywheel technology is a very important part of our future. Through my research, I have learned that flywheels are able to store massive amounts of energy. They can be described as an electro-mechanical battery that stores kinetic energy while rotating. The faster it rotates, the more energy it stores. Their lifetime is about triple that of an ordinary battery. Flywheels also have the ability to combine energy storage with attitude control all in a single system. Attitude control is the ability to position a satellite as required. FIDO helps us to understand the rotational force (torque) that is applied upon a turn-table or satellite during wheel acceleration

  13. Rapid E-learning Development Strategies and a Multimedia Project Design Model (United States)

    Sözcü, Ömer Faruk; Ipek, Ismail


    The purpose of the study is to discuss e-learning design strategies which can be used for multimedia projects as a design model. Recent advances in instructional technologies have been found to be very important in the design of training courses by using rapid instructional design (ID) approaches. The approaches were developed to use in training…

  14. Memory management and compiler support for rapid recovery from failures in computer systems (United States)

    Fuchs, W. K.


    This paper describes recent developments in the use of memory management and compiler technology to support rapid recovery from failures in computer systems. The techniques described include cache coherence protocols for user transparent checkpointing in multiprocessor systems, compiler-based checkpoint placement, compiler-based code modification for multiple instruction retry, and forward recovery in distributed systems utilizing optimistic execution.

  15. Microbial community structure and a core microbiome in biological rapid sand filters at Danish waterworks

    DEFF Research Database (Denmark)

    Gülay, Arda; Musovic, Sanin; Albrechtsen, Hans-Jørgen

    Rapid sand filtration is a traditional and common technology for drinking water purification from groundwater. Despite its wide scale and long-term use, the diversity and characterization of microbial communities in these engineered systems have remained unexplored and their roles in removal...

  16. A scoping review of rapid review methods. (United States)

    Tricco, Andrea C; Antony, Jesmin; Zarin, Wasifa; Strifler, Lisa; Ghassemi, Marco; Ivory, John; Perrier, Laure; Hutton, Brian; Moher, David; Straus, Sharon E


    Rapid reviews are a form of knowledge synthesis in which components of the systematic review process are simplified or omitted to produce information in a timely manner. Although numerous centers are conducting rapid reviews internationally, few studies have examined the methodological characteristics of rapid reviews. We aimed to examine articles, books, and reports that evaluated, compared, used or described rapid reviews or methods through a scoping review. MEDLINE, EMBASE, the Cochrane Library, internet websites of rapid review producers, and reference lists were searched to identify articles for inclusion. Two reviewers independently screened literature search results and abstracted data from included studies. Descriptive analysis was conducted. We included 100 articles plus one companion report that were published between 1997 and 2013. The studies were categorized as 84 application papers, seven development papers, six impact papers, and four comparison papers (one was included in two categories). The rapid reviews were conducted between 1 and 12 months, predominantly in Europe (58 %) and North America (20 %). The included studies failed to report 6 % to 73 % of the specific systematic review steps examined. Fifty unique rapid review methods were identified; 16 methods occurred more than once. Streamlined methods that were used in the 82 rapid reviews included limiting the literature search to published literature (24 %) or one database (2 %), limiting inclusion criteria by date (68 %) or language (49 %), having one person screen and another verify or screen excluded studies (6 %), having one person abstract data and another verify (23 %), not conducting risk of bias/quality appraisal (7 %) or having only one reviewer conduct the quality appraisal (7 %), and presenting results as a narrative summary (78 %). Four case studies were identified that compared the results of rapid reviews to systematic reviews. Three studies found that the conclusions between

  17. New developments in rapidly solidified magnesium alloys

    Energy Technology Data Exchange (ETDEWEB)

    Das, S.K. [Allied-Signal, Inc., Morristown, NJ (United States); Chang, C.F. [Allied-Signal, Inc., Morristown, NJ (United States); Raybould, D. [Allied-Signal, Inc., Morristown, NJ (United States); King, J.F. [Magnesium Elektron Ltd., Manchester (United Kingdom); Thistlethwaite, S. [Magnesium Elektron Ltd., Manchester (United Kingdom)


    In the present paper, we will examine the new developments in the rapidly solidified Mg-Al-Zn-Nd (EA55RS) alloy. We shall first briefly review the process scale-up currently employed for producing rapidly solidified magnesium alloys in large quantities, and then discuss the effect of billet size and processing parameters on the mechanical properties of various mill product forms such as extrusions and sheets. The superplastic behavior of EA55RS extrusions and rolled sheets are also discussed. Finally, some results on magnesium metal-matrix composites using rapidly solidified EA55RS matrix powders and SiC particulates are presented. (orig.)

  18. RAPID: real-time analytics platform for interactive data-mining in a decision support scenario (United States)

    Vanni, Michelle; Kase, Sue E.; Karunasekara, Shanika; Falzon, Lucia; Harwood, Aaron


    Real-time Analytics Platform for Interactive Data-mining (RAPID), a collaboration of University of Melbourne and Australia's Defense Science and Technology Group (DSTG), consumes data streams, performs analytics computations, and produces high-quality knowledge for analysts. RAPID takes topic seed words and autonomously identifies emerging keywords in the data. Users direct the system, setting time-windowing parameters, thresholds, update intervals and sample rates. Apache Storm and Apache Kafka permit real-time streaming while logging options support off-line processing. Decision-support scenarios feature Commander Critical Information Requirements involving comparisons over time and time-sequencing of events, capabilities particularly well-served by RAPID technology, to be demonstrated in the presentation.

  19. Hubungan antara Knowledge-Technology-Innovation (KTI), Commitment, Competence, Leadership, Government Policy, Human Capital, dan Competitive Advantage

    National Research Council Canada - National Science Library

    Darjat Sudrajat


    .... Rapid and unpredictable changes insist the companies should always be innovative, so that aspects of globalization, e-business, technology innovation, creativity, global competition, knowledge...

  20. Wireless Sensor Technologies and Applications

    Directory of Open Access Journals (Sweden)

    Feng Xia


    Full Text Available Recent years have witnessed tremendous advances in the design and applications of wirelessly networked and embedded sensors. Wireless sensor nodes are typically low-cost, low-power, small devices equipped with limited sensing, data processing and wireless communication capabilities, as well as power supplies. They leverage the concept of wireless sensor networks (WSNs, in which a large (possibly huge number of collaborative sensor nodes could be deployed. As an outcome of the convergence of micro-electro-mechanical systems (MEMS technology, wireless communications, and digital electronics, WSNs represent a significant improvement over traditional sensors. In fact, the rapid evolution of WSN technology has accelerated the development and deployment of various novel types of wireless sensors, e.g., multimedia sensors. Fulfilling Moore’s law, wireless sensors are becoming smaller and cheaper, and at the same time more powerful and ubiquitous. [...