WorldWideScience

Sample records for coherent beam combining

  1. Coherent beam combining architectures for high power tapered laser arrays

    Science.gov (United States)

    Schimmel, G.; Janicot, S.; Hanna, M.; Decker, J.; Crump, P.; Erbert, G.; Witte, U.; Traub, M.; Georges, P.; Lucas-Leclin, G.

    2017-02-01

    Coherent beam combining (CBC) aims at increasing the spatial brightness of lasers. It consists in maintaining a constant phase relationship between different emitters, in order to combine them constructively in one single beam. We have investigated the CBC of an array of five individually-addressable high-power tapered laser diodes at λ = 976 nm, in two architectures: the first one utilizes the self-organization of the lasers in an interferometric extended-cavity, which ensures their mutual coherence; the second one relies on the injection of the emitters by a single-frequency laser diode. In both cases, the coherent combining of the phase-locked beams is ensured on the front side of the array by a transmission diffractive grating with 98% efficiency. The passive phase-locking of the laser bar is obtained up to 5 A (per emitter). An optimization algorithm is implemented to find the proper currents in the five ridge sections that ensured the maximum combined power on the front side. Under these conditions we achieve a maximum combined power of 7.5 W. In the active MOPA configuration, we can increase the currents in the tapered sections up to 6 A and get a combined power of 11.5 W, corresponding to a combining efficiency of 76%. It is limited by the beam quality of the tapered emitters and by fast phase fluctuations between emitters. Still, these results confirm the potential of CBC approaches with tapered lasers to provide a high-power and high-brightness beam, and compare with the current state-of-the-art with laser diodes.

  2. Propagation of coherently combined truncated laser beam arrays with beam distortions in non-Kolmogorov turbulence.

    Science.gov (United States)

    Tao, Rumao; Si, Lei; Ma, Yanxing; Zhou, Pu; Liu, Zejin

    2012-08-10

    The propagation properties of coherently combined truncated laser beam arrays with beam distortions through non-Kolmogorov turbulence are studied in detail both analytically and numerically. The analytical expressions for the average intensity and the beam width of coherently combined truncated laser beam arrays with beam distortions propagating through turbulence are derived based on the combination of statistical optics methods and the extended Huygens-Fresnel principle. The effect of beam distortions, such as amplitude modulation and phase fluctuation, is studied by numerical examples. The numerical results reveal that phase fluctuations have significant influence on the spreading of coherently combined truncated laser beam arrays in non-Kolmogorov turbulence, and the effects of the phase fluctuations can be negligible as long as the phase fluctuations are controlled under a certain level, i.e., a>0.05 for the situation considered in the paper. Furthermore, large phase fluctuations can convert the beam distribution rapidly to a Gaussian form, vary the spreading, weaken the optimum truncation effects, and suppress the dependence of spreading on the parameters of the non-Kolmogorov turbulence.

  3. Novel adaptive fiber-optics collimator for coherent beam combination.

    Science.gov (United States)

    Zhi, Dong; Ma, Pengfei; Ma, Yanxing; Wang, Xiaolin; Zhou, Pu; Si, Lei

    2014-12-15

    In this manuscript, we experimentally validate a novel design of adaptive fiber-optics collimator (AFOC), which utilizes two levers to enlarge the movable range of the fiber end cap. The enlargement of the range makes the new AFOC possible to compensate the end-cap/tilt aberration in fiber laser beam combining system. The new AFOC based on flexible hinges and levers was fabricated and the performance of the new AFOC was tested carefully, including its control range, frequency response and control accuracy. Coherent beam combination (CBC) of two 5-W fiber amplifiers array with simultaneously end-cap/tilt control and phase-locking control was implemented successfully with the novel AFOC. Experimental results show that the average normalized power in the bucket (PIB) value increases from 0.311 to 0.934 with active phasing and tilt aberration compensation simultaneously, and with both controls on, the fringe contrast improves to more than 82% from 0% for the case with both control off. This work presents a promising structure for tilt aberration control in high power CBC system.

  4. Experimental demonstration of spatially coherent beam combining using optical parametric amplification.

    Science.gov (United States)

    Kurita, Takashi; Sueda, Keiichi; Tsubakimoto, Koji; Miyanaga, Noriaki

    2010-07-05

    We experimentally demonstrated coherent beam combining using optical parametric amplification with a nonlinear crystal pumped by random-phased multiple-beam array of the second harmonic of a Nd:YAG laser at 10-Hz repetition rate. In the proof-of-principle experiment, the phase jump between two pump beams was precisely controlled by a motorized actuator. For the demonstration of multiple-beam combining a random phase plate was used to create random-phased beamlets as a pump pulse. Far-field patterns of the pump, the signal, and the idler indicated that the spatially coherent signal beams were obtained on both cases. This approach allows scaling of the intensity of optical parametric chirped pulse amplification up to the exa-watt level while maintaining diffraction-limited beam quality.

  5. Digital holography for coherent fiber beam combining with a co-propagative scheme.

    Science.gov (United States)

    Antier, Marie; Larat, Christian; Lallier, Eric; Bourderionnet, Jérôme; Primot, Jérôme; Brignon, Arnaud

    2014-09-22

    We present a technique for passive coherent fiber beam combining based on digital holography. In this method, the phase errors between the fibers are compensated by the diffracted phase-conjugated -1 order of a digital hologram. Unlike previous digital holography technique, the probe beams measuring the phase errors between the fibers are co-propagating with the phase-locked signal beams. This architecture is compatible with the use of multi-stage isolated amplifying fibers. It does not require any phase calculation algorithm and its correction is collective. This concept is experimentally demonstrated with three fibers at 1.55 μm. A residual phase error of λ/20 is measured.

  6. Coherent beam-beam effects

    International Nuclear Information System (INIS)

    Chao, A.W.

    1992-01-01

    There are two physical pictures that describe the beam-beam interaction in a storage ring collider: The weak-strong and the strong-strong pictures. Both pictures play a role in determining the beam-beam behavior. This review addresses only the strong-strong picture. The corresponding beam dynamical effects are referred to as the coherent beam-beam effects. Some basic knowledge of the weak-strong picture is assumed. To be specific, two beams of opposite charges are considered. (orig.)

  7. Partially coherent isodiffracting pulsed beams

    Science.gov (United States)

    Koivurova, Matias; Ding, Chaoliang; Turunen, Jari; Pan, Liuzhan

    2018-02-01

    We investigate a class of isodiffracting pulsed beams, which are superpositions of transverse modes supported by spherical-mirror laser resonators. By employing modal weights that, for stationary light, produce a Gaussian Schell-model beam, we extend this standard model to pulsed beams. We first construct the two-frequency cross-spectral density function that characterizes the spatial coherence in the space-frequency domain. By assuming a power-exponential spectral profile, we then employ the generalized Wiener-Khintchine theorem for nonstationary light to derive the two-time mutual coherence function that describes the space-time coherence of the ensuing beams. The isodiffracting nature of the laser resonator modes permits all (paraxial-domain) calculations at any propagation distance to be performed analytically. Significant spatiotemporal coupling is revealed in subcycle, single-cycle, and few-cycle domains, where the partial spatial coherence also leads to reduced temporal coherence even though full spectral coherence is assumed.

  8. Coherence matrix of plasmonic beams

    DEFF Research Database (Denmark)

    Novitsky, Andrey; Lavrinenko, Andrei

    2013-01-01

    We consider monochromatic electromagnetic beams of surface plasmon-polaritons created at interfaces between dielectric media and metals. We theoretically study non-coherent superpositions of elementary surface waves and discuss their spectral degree of polarization, Stokes parameters, and the for...... of the spectral coherence matrix. We compare the polarization properties of the surface plasmonspolaritons as three-dimensional and two-dimensional fields concluding that the latter is superior....

  9. Coherent combining pulse bursts in time domain

    Science.gov (United States)

    Galvanauskas, Almantas

    2018-01-09

    A beam combining and pulse stacking technique is provided that enhances laser pulse energy by coherent stacking pulse bursts (i.e. non-periodic pulsed signals) in time domain. This energy enhancement is achieved by using various configurations of Fabry-Perot, Gires-Tournois and other types of resonant cavities, so that a multiple-pulse burst incident at either a single input or multiple inputs of the system produces an output with a solitary pulse, which contains the summed energy of the incident multiple pulses from all beams. This disclosure provides a substantial improvement over conventional coherent-combining methods in that it achieves very high pulse energies using a relatively small number of combined laser systems, thus providing with orders of magnitude reduction in system size, complexity, and cost compared to current combining approaches.

  10. Electron beam instrumentation techniques using coherent radiation

    International Nuclear Information System (INIS)

    Wang, D.X.

    1997-01-01

    Much progress has been made on coherent radiation research since coherent synchrotron radiation was first observed in 1989. The use of coherent radiation as a bunch length diagnostic tool has been studied by several groups. In this paper, brief introductions to coherent radiation and far-infrared measurement are given, the progress and status of their beam diagnostic application are reviewed, different techniques are described, and their advantages and limitations are discussed

  11. Coherent combination of ultrafast fiber amplifiers

    International Nuclear Information System (INIS)

    Hanna, Marc; Guichard, Florent; Druon, Frédéric; Georges, Patrick; Zaouter, Yoann; Papadopoulos, Dimitris N

    2016-01-01

    We review recent progress in coherent combining of femtosecond pulses amplified in optical fibers as a way to scale the peak and average power of ultrafast sources. Different methods of achieving coherent pulse addition in space (beam combining) and time (divided pulse amplification) domains are described. These architectures can be widely classified into active methods, where the relative phases between pulses are subject to a servomechanism, and passive methods, where phase matching is inherent to the geometry. Other experiments that combine pulses with different spectral contents, pulses that have been nonlinearly broadened or successive pulses from a mode-locked laser oscillator, are then presented. All these techniques allow access to unprecedented parameter range for fiber ultrafast sources. (topical review)

  12. Coherent Beam-Beam Effects in the LHC

    CERN Document Server

    Alexahin, Yu I; Herr, Werner; Zorzano-Mier, M P

    2001-01-01

    In the Large Hadron Collider (LHC) two proton beams of similar intensities collide in several interaction points. It is well known that the head-on collision of two beams of equal strength can excite coherent modes whose frequencies are separated from the incoherent spectrum of oscillations of individual particles. This can lead to the loss of Landau damping and possibly to unstable motion. The beam-beam effect in the LHC is further complicated by a large number of bunches (2808 per beam), a finite crossing angle and gaps in the bunch train. The coherent beam-beam effects under various conditions and operational scenarios are studied analytically and with multiparticle simulations. We give an overview of the main results and present proposals to overcome these difficulties together with possible side effects.

  13. Coherent Beam-Beam Oscillations at the LHC

    CERN Document Server

    Zorzano-Mier, M P

    1999-01-01

    The transverse coherent motion of the two colliding LHC beams is studied by multi-particle tracking, where the beam-beam force is calculated assuming a Gaussian beam distribution with variable barycentres and rms beam sizes. The simulation yields the coherent and incoherent oscillation frequencies, the emittance growth of either beam, and evidence for the existence or lack of Landau damping. The transverse beam sizes change with the fractional part of the tune as expected from the dynamic beta effect. For head-on collisions, we find that the pi-mode frequency lies outside of the continuum frequency spread if the ratio of the beam-beam parameters exceeds 0.6, in accordance with predictions [1]. For smaller ratios, the pi-mode is Landau damped. When long range interactions are also included, undamped coherent modes do still exist outside the continuum, both with and without alternating crossing planes at two interaction points. However, the simulation shows that separating the tunes of the two beams can restore...

  14. Coherently combined 16-channel multicore fiber laser system.

    Science.gov (United States)

    Klenke, A; Müller, M; Stark, H; Stutzki, F; Hupel, C; Schreiber, T; Tünnermann, A; Limpert, J

    2018-04-01

    We present a coherently combined laser amplifier with 16 channels from a multicore fiber in a proof-of-principle demonstration. Filled-aperture beam splitting and combination, together with temporal phasing, is realized in a compact and low-component-count setup. Combined average power of up to 70 W with 40 ps pulses is achieved with combination efficiencies around 80%.

  15. Optimal coherence for beam propagation through random media

    Science.gov (United States)

    Schulz, Timothy J.; Liu, Baoyong

    2005-08-01

    In this paper we consider the optimal coherence for beam propagation through random media. First, we demonstrate that a beam that maximizes the average receiver intensity is fully coherent, and that the upper bounds on received intensity are nearly attained by a beam that is focused for clear air. Second, we demonstrate that a beam that maximizes the scintillation index (along with other criteria that trade-off the mean and standard deviation for the received intensity) is, in general, partially coherent. We conclude with an example in which modal intensities are optimized for a beam that is constructed from Hermite-Gaussian modes.

  16. Detection of coherent beam-beam modes with digitized beam position monitor signals

    CERN Document Server

    Stancari, G.; White, S.M.

    2014-01-01

    A system for bunch-by-bunch detection of transverse proton and antiproton coherent oscillations in the Fermilab Tevatron collider is described. It is based on the signal from a single beam-position monitor located in a region of the ring with large amplitude functions. The signal is digitized over a large number of turns and Fourier-analyzed offline with a dedicated algorithm. To enhance the signal, band-limited noise is applied to the beam for about 1 s. This excitation does not adversely affect the circulating beams even at high luminosities. The device has a response time of a few seconds, a frequency resolution of $1.6\\times 10^{-5}$ in fractional tune, and it is sensitive to oscillation amplitudes of 60 nm. It complements Schottky detectors as a diagnostic tool for tunes, tune spreads, and beam-beam effects. Measurements of coherent mode spectra are presented and compared with models of beam-beam oscillations.

  17. Report on single beam stability - coherent effects

    International Nuclear Information System (INIS)

    Brouzet, E.; Gareyte, J.; Hofmann, A.; Laclare, J.C.; Leleux, G.; Miles, J.; Schindl, K.H.

    1980-01-01

    Group 1A was concerned with single beam stability, coherent effects. Theory is available. Most of the material for this work was drawn from F.J. Sacherer theory which has been left in reasonably good shape in the sense that given any coupling impedance, its effect on the beam can be estimated. The EBI computer program was extensively used in this respect. We still lack thorough knowledge of the SPS coupling impedance. Accordingly our results rest on a model. This model should be too unrealistic since it originates from various data of the SPS and other machines. Nevertheless any complementary information about the SPS impedance would be welcome. Broad-band impedance and parasitic effects on transverse and longitudinal motions will be reviewed. We shall mainly focus on the 270 GeV case with six equidistant bunches and 10 11 particles per bunch. For other schemes results can be obtained in a similar fashion. Some relevant figures will be given for the situation at injection. (orig.)

  18. Coherent Diffraction Radiation Longitudinal Beam Profile Monitor for CTF3

    CERN Document Server

    Micheler, Maximilian; Boorman, Gary; Karataev, Pavel; Lekomtsev, Konstantin; Molloy, Stephen; Corsini, Roberto; Dabrowski, Anne; Lefevre, Thibaut

    2010-01-01

    A setup for the investigation of Coherent Diffraction Radiation (CDR) from a conducting screen as a tool for noninvasive longitudinal electron beam profile diagnostics has been designed and installed in the Combiner Ring Measurement (CRM) line of the CLIC Test Facility (CTF3, CERN). In this report the status of the monitor development and results on the interferometric measurements of CDR spectra are presented. The CDR signal correlation with an RF pickup and a streak camera is reported. The future plans for the system improvements are also discussed

  19. In vivo endoscopic multi-beam optical coherence tomography

    Energy Technology Data Exchange (ETDEWEB)

    Standish, Beau A; Mariampillai, Adrian; Munce, Nigel R; Leung, Michael K K; Vitkin, I Alex [Deptartment of Medical Biophysics, University of Toronto, Toronto (Canada); Lee, Kenneth K C; Yang, Victor X D [Ontario Cancer Institute/University Health Network, Toronto (Canada)], E-mail: standish@ee.ryerson.ca

    2010-02-07

    A multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 {mu}m full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation between the structural multi-beam OCT images and H and E histology was achieved, demonstrating the feasibility of this high-resolution system and its potential for in vivo human endoscopic imaging.

  20. In vivo endoscopic multi-beam optical coherence tomography

    International Nuclear Information System (INIS)

    Standish, Beau A; Mariampillai, Adrian; Munce, Nigel R; Leung, Michael K K; Vitkin, I Alex; Lee, Kenneth K C; Yang, Victor X D

    2010-01-01

    A multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 μm full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation between the structural multi-beam OCT images and H and E histology was achieved, demonstrating the feasibility of this high-resolution system and its potential for in vivo human endoscopic imaging.

  1. Investigation of Laser Beam Combining and Clean-Up via Seeded Stimulated Brillouin Scattering in Multimode Optical Fibers

    National Research Council Canada - National Science Library

    Choi, Bryan

    2000-01-01

    .... Beam combining in multimode fibers via SBS is being considered as a method of combining low power laser beams into a single beam having higher power and superior spatial coherence for applications...

  2. Coherent instabilities of a relativistic bunched beam

    International Nuclear Information System (INIS)

    Chao, A.W.

    1982-06-01

    A charge-particle beam contained in an accelerator vacuum chamber interacts electromagnetically with its environment to create a wake field. This field than acts back on the beam, perturbing the particle motion. If the beam intensity is high enough, this beam-environment interaction may lead to an instability and to subsequent beam loss. The beam and its environment form a dynamical system, and it is this system that will be studied. 84 references

  3. Coherent instabilities of a relativistic bunched beam

    Energy Technology Data Exchange (ETDEWEB)

    Chao, A.W.

    1982-06-01

    A charge-particle beam contained in an accelerator vacuum chamber interacts electromagnetically with its environment to create a wake field. This field than acts back on the beam, perturbing the particle motion. If the beam intensity is high enough, this beam-environment interaction may lead to an instability and to subsequent beam loss. The beam and its environment form a dynamical system, and it is this system that will be studied. 84 references.

  4. Further evidence of antibunching of two coherent beams of fermions

    International Nuclear Information System (INIS)

    Iannuzzi, M.; Messi, R.; Moricciani, D.; Orecchini, A.; Sacchetti, F.; Facchi, P.; Pascazio, S.

    2011-01-01

    We describe an experiment confirming the evidence of the antibunching effect on a beam of noninteracting thermal neutrons. The comparison between the results recorded with a high-energy-resolution source of neutrons and those recorded with a broad-energy-resolution source enables us to clarify the role played by the beam coherence in the occurrence of the antibunching effect.

  5. Simulations of coherent beam-beam modes at the Large Hadron Collider

    CERN Document Server

    Zorzano-Mier, M P

    2000-01-01

    The transverse coherent motion of two colliding proton beams at the Large Hadron Collider is studied by multiparticle tracking. We use the beam-beam force for a Gaussian beam distribution with variable barycenters and rms beam sizes, and optionally include the effect of long-range collisions and external impedance. The simulation yields the coherent and incoherent oscillation frequencies, the emittance growth of either beam, and evidence for the existence or lack of Landau damping. For head-on collisions of beams with equal sizes, we find that the pi -mode frequency lies outside of the continuum frequency spread, if the ratio of the beam-beam parameters exceeds 0.6, in accordance with predictions. For smaller ratios of the beam- beam parameters, or if, for equal beam-beam parameters, the beam sizes are widely different, the pi mode is Landau damped. When long- range collisions are also included, undamped coherent modes do still exist outside the continuum, both with and without alternating crossing planes at ...

  6. Average intensity and coherence properties of a partially coherent Lorentz-Gauss beam propagating through oceanic turbulence

    Science.gov (United States)

    Liu, Dajun; Wang, Guiqiu; Wang, Yaochuan

    2018-01-01

    Based on the Huygens-Fresnel integral and the relationship of Lorentz distribution and Hermite-Gauss function, the average intensity and coherence properties of a partially coherent Lorentz-Gauss beam propagating through oceanic turbulence have been investigated by using numerical examples. The influences of beam parameters and oceanic turbulence on the propagation properties are also discussed in details. It is shown that the partially coherent Lorentz-Gauss beam with smaller coherence length will spread faster in oceanic turbulence, and the stronger oceanic turbulence will accelerate the spreading of partially coherent Lorentz-Gauss beam in oceanic turbulence.

  7. Spectral coherence along a lidar-anemometer beam

    Energy Technology Data Exchange (ETDEWEB)

    Kristensen, Leif; Kirkegaard, P.; Mann, J.; Mikkelsen, Torben; Nielsen, Morten; Sjoeholm, M.

    2010-10-15

    The theory of measuring the spectral coherence by means of a lidar anemometer has been outlined. It is based on the assumption that the turbulent velocity field can be considered statistically locally isotropic and on the validity of Taylor's hypothesis. This implies that the longitudinal coherence cannot be predicted realistically. Special emphasis has been placed on the effect of line average along the beam. One section has been devoted to the effect of spectral aliasing, which may cause severe problems in the interpretation of measured data. This work is considered the theoretical background for the understanding of the coherences calculated on basis of real date. (Author)

  8. Internal dynamics of intense twin beams and their coherence

    Czech Academy of Sciences Publication Activity Database

    Peřina Jr., J.; Haderka, Ondřej; Allevi, A.; Bondani, M.

    2016-01-01

    Roč. 6, Feb (2016), 1-8, č. článku 22320. ISSN 2045-2322 R&D Projects: GA ČR GAP205/12/0382 Institutional support: RVO:68378271 Keywords : dynamics of intense * twin beams * pump-depleted parametric * down-conversion * coherence Subject RIV: BH - Optics, Masers, Lasers Impact factor: 4.259, year: 2016

  9. A survey of beam-combining technologies for laser space power transmission

    Science.gov (United States)

    Kwon, J. H.; Williams, M. D.; Lee, J. H.

    1988-01-01

    The combination of laser beams holds much promise for obtaining powerful beams. Methods are surveyed for beam combination (coherent and incoherent) and two of them are identified as the most effective means for achieving high power transmission in space. The two methods as applied to laser diode arrays are analyzed, and potentially productive work areas for the advancement of technology are delineated.

  10. Understanding Beam Alignment in a Coherent Lidar System

    Science.gov (United States)

    Prasad, Narasimha S.; Roychoudhari, Chandrasekhar

    2015-01-01

    Optical beam alignment in a coherent lidar (or ladar) receiver system plays a critical role in optimizing its performance. Optical alignment in a coherent lidar system dictates the wavefront curvature (phase front) and Poynting vector) matching of the local oscillator beam with the incoming receiver beam on a detector. However, this alignment is often not easy to achieve and is rarely perfect. Furthermore, optical fibers are being increasingly used in coherent lidar system receivers for transporting radiation to achieve architectural elegance. Single mode fibers also require stringent mode matching for efficient light coupling. The detector response characteristics vary with the misalignment of the two pointing vectors. Misalignment can lead to increase in DC current. Also, a lens in front of the detector may exasperate phase front and Poynting vector mismatch. Non-Interaction of Waves, or the NIW property indicates the light beams do not interfere by themselves in the absence of detecting dipoles. In this paper, we will analyze the extent of misalignment on the detector specifications using pointing vectors of mixing beams in light of the NIW property.

  11. Active beam integrator for high power coherent lasers

    Energy Technology Data Exchange (ETDEWEB)

    Laguarta, F.; Armengol, J.; Vega, F.; Lupon, N. [Univ. Politecnica de Catalunya, Terrassa (Spain). Dept. d`Optica i Optometria

    1996-12-31

    In laser materials processing applications it is often necessary to work with uniform intensity distributions. This goal is quite difficult to achieve when dealing with high power laser beams, and becomes critical for a successful application involving surface heat treatment of non-metallic materials. The authors have designed and tested a very simple beam shaper for transforming the initial intensity distribution of a CO{sub 2} laser beam mode into a more uniform intensity profile. The beam shaper is a two-faceted mirror for active integration of high power coherent laser beams. After reflection in the faceted mirror, a TEM00 or TEM01 CO{sub 2} laser beam is divided into two beamlets that overlap to give a more uniform intensity distribution. A sharp interference pattern due to the high spatial coherence of the incident beam appears. This interference pattern is actively integrated by a high-frequency longitudinal displacement of one of the facets. This provides a change in the relative phase of the two beamlets, and consequently the interference pattern vibrates and its contribution to the intensity distribution averages out. When sweeping this distribution over a sample, a uniform amount of energy is deposited at every point of its surface. It must be emphasized that unlike multifaceted mirrors, the two-facet integrator may provide uniform intensity profiles over any working distance. Finally, as in other integration devices an imaging system may be used to obtain a spot of the shape and the size desired for a particular application.

  12. Experimental verification of focusability of coherent annular laser beams

    Science.gov (United States)

    Astadjov, Dimo N.; Prakash, Om

    2013-03-01

    Experiments of focusing coherent laser beams being diffracted on annular aperture are carried out in order to verify issues of a two-dimensional Fast Fourier Transform simulation of coherent pure (dark) annular flat beams done and published before. The beam pattern at focal plane (aka the far-field pattern) is a prominent central peak and faint concentrical rings around it. In the course of simulation we calculate the fraction of the central peak power to the whole power of beam that gives a notion of power spread within the focal spot. This fraction is a function of beam annularity i.e. `inside diameter /outside diameter' ratio. The experimentally-measured dependence of the central peak power to the whole power of beam versus the annularity of pure annular laser beams was the major target of the report. The purpose was to verify experimentally the issues of our earlier simulation. We found that from the five experimental points four of them are within 16% error as to the simulated dependence which is tolerable in such a measurement.

  13. Beam based feedback for the Linac coherent light source

    International Nuclear Information System (INIS)

    Fairley, D.; Kim, K.; Luchini, K; Natampalli, P.; Piccoli, L.; Rogind, D.; Straumann, T.

    2012-01-01

    Beam-based feedback control loops are required by the Linac Coherent Light Source (LCLS) program in order to provide fast, single-pulse stabilization of beam parameters. Eight transverse feedback loops, a 6*6 longitudinal feedback loop, and a loop to maintain the electron bunch charge have been commissioned on the LCLS, and have been maintaining stability of the LCLS electron beam at beam rates up to 120 Hz. This paper will discuss the design, configuration and commissioning of the beam-based Fast Feedback System for LCLS. Topics include algorithms for 120 Hz feedback, multi-cast network performance, actuator and sensor performance for single-pulse control and sensor read back, and feedback configuration and run-time control. (authors)

  14. Coherent emission from relativistic beam-plasma interactions

    International Nuclear Information System (INIS)

    Latham, P.E.

    1986-01-01

    A theoretical model for the production of high-power, high-frequency electromagnetic radiation from unmagnetized, relativistic beam-plasma interactions is studied. Emphasis is placed on the injected-beam system, for which the dominant portion of the radiation is emitted near the point where the beam enters the plasma. In such systems, frequencies much larger than the plasma frequency and power levels many orders of magnitude above that predicted by single-particle radiation have been observed experimentally. A two-step process is proposed to explain these observations: electrostatic bunching of the beam followed by coherent radiation by the bunches. The first step, beam bunching, produces large-amplitude electrostatic waves. A Green's function analysis is employed to understand the convective growth of those waves near the plasma boundary; their saturation amplitude is found by applying conservation of energy to the beam-plasma system. An azimuthally symmetric model is used to compute the saturated spectrum analytically, and a relatively simple expression is found. The second step, the interaction of the electron beam with the electrostatic spectrum, leads to the production of high-power, high-frequency electromagnetic radiation. From a detailed analysis of the phase-space evolution of the trapped beam, an analytic expression for the electromagnetic spectrum is found as a function of angle and frequency

  15. Editorial: Focus on X-ray Beams with High Coherence

    Science.gov (United States)

    Robinson, Ian; Gruebel, Gerhard; Mochrie, Simon

    2010-03-01

    This editorial serves as the preface to a special issue of New Journal of Physics, which collects together solicited papers on a common subject, x-ray beams with high coherence. We summarize the issue's content, and explain why there is so much current interest both in the sources themselves and in the applications to the study of the structure of matter and its fluctuations (both spontaneous and driven). As this collection demonstrates, the field brings together accelerator physics in the design of new sources, particle physics in the design of detectors, and chemical and materials scientists who make use of the coherent beams produced. Focus on X-ray Beams with High Coherence Contents Femtosecond pulse x-ray imaging with a large field of view B Pfau, C M Günther, S Schaffert, R Mitzner, B Siemer, S Roling, H Zacharias, O Kutz, I Rudolph, R Treusch and S Eisebitt The FERMI@Elettra free-electron-laser source for coherent x-ray physics: photon properties, beam transport system and applications E Allaria, C Callegari, D Cocco, W M Fawley, M Kiskinova, C Masciovecchio and F Parmigiani Beyond simple exponential correlation functions and equilibrium dynamics in x-ray photon correlation spectroscopy Anders Madsen, Robert L Leheny, Hongyu Guo, Michael Sprung and Orsolya Czakkel The Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS) Sébastien Boutet and Garth J Williams Dynamics and rheology under continuous shear flow studied by x-ray photon correlation spectroscopy Andrei Fluerasu, Pawel Kwasniewski, Chiara Caronna, Fanny Destremaut, Jean-Baptiste Salmon and Anders Madsen Exploration of crystal strains using coherent x-ray diffraction Wonsuk Cha, Sanghoon Song, Nak Cheon Jeong, Ross Harder, Kyung Byung Yoon, Ian K Robinson and Hyunjung Kim Coherence properties of the European XFEL G Geloni, E Saldin, L Samoylova, E Schneidmiller, H Sinn, Th Tschentscher and M Yurkov Fresnel coherent diffractive imaging: treatment and analysis of data G J

  16. Beam-based Feedback for the Linac Coherent Light Source

    Energy Technology Data Exchange (ETDEWEB)

    Fairley, D.; Allison, S.; Chevtsov, S.; Chu, P.; Decker, F.J.; Emma, P.; Frisch, J.; Himel, T.; Kim, K.; Krejcik, P.; Loos, H.; Lahey, T.; Natampalli, P.; Peng, S.; Rogind, D.; Shoaee, H.; Straumann, T.; Williams, E.; White, G.; Wu, J.; Zelazney, M.; /SLAC

    2010-02-11

    Beam-based feedback control loops are required by the Linac Coherent Light Source (LCLS) program in order to provide fast, single-pulse stabilization of beam parameters. Eight transverse feedback loops, a 6 x 6 longitudinal feedback loop, and a loop to maintain the electron bunch charge were successfully prototyped in MATLAB for the LCLS, and have been maintaining stability of the LCLS electron beam at beam rates up to 30Hz. In the final commissioning phase of LCLS the beam will be operating at up to 120Hz. In order to run the feedback loops at beam rate, the feedback loops will be implemented in EPICS IOCs with a dedicated ethernet multi-cast network. This paper will discuss the design of the beam-based Fast Feedback System for LCLS. Topics include MATLAB feedback prototyping, algorithm for 120Hz feedback, network design for fast data transport, actuator and sensor design for single-pulse control and sensor readback, and feedback configuration and runtime control.

  17. Revisit of combined parallel-beam/cone-beam or fan-beam/cone-beam imaging.

    Science.gov (United States)

    Zeng, Gengsheng L

    2013-10-01

    This aim of this paper is to revisit the parallel-beam/cone-beam or fan-beam/cone-beam imaging configuration, and to investigate whether this configuration has any advantages. Twenty years ago, it was suggested to simultaneously use a parallel-beam (or a fan-beam) collimator and a cone-beam collimator to acquire single photon emission computed tomography data. The motivation was that the parallel-beam (or the fan-beam) collimator can provide sufficient sampling, while the cone-beam collimator is able to provide higher photon counts. Even with higher total counts, this hybrid system does not give significant improvement (if any) in terms of image noise and artifacts reduction. If a conventional iterative maximum-likelihood expectation-maximization algorithm is used to reconstruct the image, the resultant reconstruction may be worse than the parallel-beam-only (or fan-beam-only) system. This paper uses the singular value decomposition (SVD) analysis to explain this phenomenon. The SVD results indicate that the parallel-beam-only and the fan-beam-only system outperform the combined systems. The optimal imaging system does not necessary to be the one that generates the projections with highest signal-to-noise ratio and best resolution.

  18. Coherent Nonlinear Longitudinal Phenomena in Unbunched Synchrotron Beams

    Energy Technology Data Exchange (ETDEWEB)

    Spentzouris, Linda Klamp [Northwestern U.

    1996-12-01

    Coherent nonlinear longitudinal phenomena are studied in proton and antiproton synchrotron beams. Theoretical development done in the eld of plasma physics for resonant wave-wave coupling is applied to the case of a particle beam. Results are given from experiments done to investigate the nature of the weakly nonlinear three-wave coupling processes known as parametric coupling and echoes. Storage ring impedances are shown to amplify the parametric coupling process, underlining the possibility that machine impedances might be extracted from coupling events instigated by external excitation. Echo amplitudes are demonstrated to be sensitive to diusion processes, such as intrabeam scattering, which degrade a beam. The result of a fast diusion rate measurement using echo amplitudes is presented. In addition to the wave-wave interactions, observations of moderately nonlinear waveparticle interactions are also included. The manifestations of these interactions that are documented include nonlinear Landau damping, higher harmonic generation, and signs of the possible formation of solitons.

  19. Characterization of stochastic spatially and spectrally partially coherent electromagnetic pulsed beams

    International Nuclear Information System (INIS)

    Ding Chaoliang; Lue Baida; Pan Liuzhan

    2009-01-01

    The unified theory of coherence and polarization proposed by Wolf is extended from stochastic stationary electromagnetic beams to stochastic spatially and spectrally partially coherent electromagnetic pulsed beams. Taking the stochastic electromagnetic Gaussian Schell-model pulsed (GSMP) beam as a typical example of stochastic spatially and spectrally partially coherent electromagnetic pulsed beams, the expressions for the spectral density, spectral degree of polarization and spectral degree of coherence of stochastic electromagnetic GSMP beams propagating in free space are derived. Some special cases are analyzed. The illustrative examples are given and the results are interpreted physically.

  20. Propagation of partially coherent Lorentz-Gauss vortex beam through oceanic turbulence.

    Science.gov (United States)

    Liu, Dajun; Yin, Hongming; Wang, Guiqiu; Wang, Yaochuan

    2017-11-01

    The partially coherent Lorentz-Gauss vortex beam generated by a Schell-model source has been introduced. Based on the extended Huygens-Fresnel principle, the cross-spectral density function of a partially coherent Lorentz-Gauss vortex beam propagating in oceanic turbulence is derived. The influences of coherence length, topological charge M, and oceanic turbulence on the spreading properties and position of the coherence vortex for a partially coherent Lorentz-Gauss vortex beam are analyzed in detail. The results show that a partially coherent Lorentz-Gauss vortex beam propagating in stronger oceanic turbulence will evolve into a Gaussian-like beam more rapidly as the propagation distance increases, and the number of coherent vortices will change.

  1. LEIR impedance model and coherent beam instability observations

    CERN Document Server

    Biancacci, N; Migliorati, M; Rijoff, T L

    2017-01-01

    The LEIR machine is the first synchrotron in the ion ac-celeration chain at CERN and it is responsible to deliverhigh intensity ion beams to the LHC. Following the recentprogress in the understanding of the intensity limitations,detailed studies of the machine impedance started. In thiswork we describe the present LEIR impedance model, detail-ing the contribution to the total longitudinal and transverseimpedance of several machine elements. We then comparethe machine tune shift versus intensity predictions againstmeasurements at injection energy and summarize the co-herent instability observations in the absence of transversefeedback.

  2. Coherently combining data between detectors for all-sky semi-coherent continuous gravitational wave searches

    Science.gov (United States)

    Goetz, E.; Riles, K.

    2016-04-01

    We present a method for coherently combining short data segments from gravitational-wave detectors to improve the sensitivity of semi-coherent searches for continuous gravitational waves. All-sky searches for continuous gravitational waves from unknown sources are computationally limited. The semi-coherent approach reduces the computational cost by dividing the entire observation timespan into short segments to be analyzed coherently, then combined together incoherently. Semi-coherent analyses that attempt to improve sensitivity by coherently combining data from multiple detectors face a computational challenge in accounting for uncertainties in signal parameters. In this article, we lay out a technique to meet this challenge using summed Fourier transform coefficients. Applying this technique to one all-sky search algorithm called TwoSpect, we confirm that the sensitivity of all-sky, semi-coherent searches can be improved by coherently combining the short data segments, e.g., by up to 42% over a single detector for an all-sky search. For misaligned detectors, however, this improvement requires careful attention when marginalizing over unknown polarization parameters. In addition, care must be taken in correcting for differential detector velocity due to the Earth’s rotation for high signal frequencies and widely separated detectors.

  3. Coherently combining data between detectors for all-sky semi-coherent continuous gravitational wave searches

    International Nuclear Information System (INIS)

    Goetz, E; Riles, K

    2016-01-01

    We present a method for coherently combining short data segments from gravitational-wave detectors to improve the sensitivity of semi-coherent searches for continuous gravitational waves. All-sky searches for continuous gravitational waves from unknown sources are computationally limited. The semi-coherent approach reduces the computational cost by dividing the entire observation timespan into short segments to be analyzed coherently, then combined together incoherently. Semi-coherent analyses that attempt to improve sensitivity by coherently combining data from multiple detectors face a computational challenge in accounting for uncertainties in signal parameters. In this article, we lay out a technique to meet this challenge using summed Fourier transform coefficients. Applying this technique to one all-sky search algorithm called TwoSpect, we confirm that the sensitivity of all-sky, semi-coherent searches can be improved by coherently combining the short data segments, e.g., by up to 42% over a single detector for an all-sky search. For misaligned detectors, however, this improvement requires careful attention when marginalizing over unknown polarization parameters. In addition, care must be taken in correcting for differential detector velocity due to the Earth’s rotation for high signal frequencies and widely separated detectors. (paper)

  4. The Theory of Coherent Radiation by Intense Electron Beams

    CERN Document Server

    Buts, Vyacheslav A; Kurilko, V.I

    2006-01-01

    Spurred by the development of high-current, high-energy relativistic electron beams this books delves into the foundations of a device and geometry independent theoretical treatment of a large collection of interacting and radiating electron bunches. Part I deals with the basics of the radiation emission of a single charged particle, paying particular attention to the effect of radiation reaction and dwelling on the corresponding well-known paradoxes. Part II investigates the collective behaviour of a high-density electron bunch where both discrete and continous beam modelling is explored. Part III treats the application to modern systems while still keeping the treatment as general as possible. This book will be mandatory reading for anyone working on the foundations of modern devices such as free electron lasers, plasma accelerators, synchroton sources and other modern sources of bright, coherent radiation with high spectral density.

  5. Coherence of the vortex Bessel-Gaussian beam in turbulent atmosphere

    Science.gov (United States)

    Lukin, Igor P.

    2017-11-01

    In this paper the theoretical research of coherent properties of the vortex Bessel-Gaussian optical beams propagating in turbulent atmosphere are developed. The approach to the analysis of this problem is based on the analytical solution of the equation for the transverse second-order mutual coherence function of a field of optical radiation. The behavior of integral scale of coherence degree of vortex Bessel-Gaussian optical beams depending on parameters of an optical beam and characteristics of turbulent atmosphere is particularly considered. It is shown that the integral scale of coherence degree of a vortex Bessel-Gaussian optical beam essentially depends on value of a topological charge of a vortex optical beam. With increase in a topological charge of a vortex Bessel-Gaussian optical beam the value of integral scale of coherence degree of a vortex Bessel-Gaussian optical beam are decreased.

  6. Coherence degree of the fundamental Bessel-Gaussian beam in turbulent atmosphere

    Science.gov (United States)

    Lukin, Igor P.

    2017-11-01

    In this article the coherence of a fundamental Bessel-Gaussian optical beam in turbulent atmosphere is analyzed. The problem analysis is based on the solution of the equation for the transverse second-order mutual coherence function of a fundamental Bessel-Gaussian optical beam of optical radiation. The behavior of a coherence degree of a fundamental Bessel-Gaussian optical beam depending on parameters of an optical beam and characteristics of turbulent atmosphere is examined. It was revealed that at low levels of fluctuations in turbulent atmosphere the coherence degree of a fundamental Bessel-Gaussian optical beam has the characteristic oscillating appearance. At high levels of fluctuations in turbulent atmosphere the coherence degree of a fundamental Bessel-Gaussian optical beam is described by an one-scale decreasing curve which in process of increase of level of fluctuations on a line of formation of a laser beam becomes closer to the same characteristic of a spherical optical wave.

  7. Experimental demonstration of passive coherent combining of fiber lasers by phase contrast filtering.

    Science.gov (United States)

    Jeux, François; Desfarges-Berthelemot, Agnès; Kermène, Vincent; Barthelemy, Alain

    2012-12-17

    We report experiments on a new laser architecture involving phase contrast filtering to coherently combine an array of fiber lasers. We demonstrate that the new technique yields a more stable phase-locking than standard methods using only amplitude filtering. A spectral analysis of the output beams shows that the new scheme generates more resonant frequencies common to the coupled lasers. This property can enhance the combining efficiency when the number of lasers to be coupled is large.

  8. Coherent combining of high brightness tapered lasers in master oscillator power amplifier configuration

    Science.gov (United States)

    Albrodt, P.; Hanna, M.; Moron, F.; Decker, J.; Winterfeldt, M.; Blume, G.; Erbert, G.; Crump, P.; Georges, P.; Lucas-Leclin, G.

    2018-02-01

    Improved diode laser beam combining techniques are in strong demand for applications in material processing. Coherent beam combining (CBC) is the only combining approach that has the potential to maintain or even improve all laser properties, and thus has high potential for future systems. As part of our ongoing studies into CBC of diode lasers, we present recent progress in the coherent superposition of high-power single-pass tapered laser amplifiers. The amplifiers are seeded by a DFB laser at λ = 976 nm, where the seed is injected into a laterally single-mode ridge-waveguide input section. The phase pistons on each beam are actively controlled by varying the current in the ridge section of each amplifier, using a sequential hill-climbing algorithm, resulting in a combined beam with power fluctuations of below 1%. The currents into the tapered sections of the amplifiers are separately controlled, and remain constant. In contrast to our previous studies, we favour a limited number of individual high-power amplifiers, in order to preserve a high extracted power per emitter in a simple, low-loss coupling arrangement. Specifically, a multi-arm interferometer architecture with only three devices is used, constructed using 6 mm-long tapered amplifiers, mounted junction up on C-mounts, to allow separate contact to single mode and amplifier sections. A maximum coherently combined power of 12.9 W is demonstrated in a nearly diffraction-limited beam, corresponding to a 65% combining efficiency, with power mainly limited by the intrinsic beam quality of the amplifiers. Further increased combined power is currently sought.

  9. Transverse characterization of focused Bessel beams with angular momentum applied to study degree of coherence

    International Nuclear Information System (INIS)

    He, Xi; Wu, Fengtie; Chen, Ziyang; Pu, Jixiong; Chavez-Cerda, Sabino

    2016-01-01

    The transverse focusing properties at the ‘pseudo-focal’ plane of coherent Bessel beams with angular momentum are analyzed in detail. The transverse magnification of the central dark region of Bessel beams at this pseudo-focal plane is derived for the first time by calculating the ratio of the magnitude of the transverse components of the corresponding wave vectors before and after the focusing lens. We test our results experimentally with coherent laser Bessel beams and excellent agreement is observed. Then, an LED light source is used to generate Bessel beams. By modifying the coherence of the LED light source, we observe that by reducing coherence a smaller and shallower central dark region of Bessel beams with angular momentum is produced at the pseudo-focal plane. This technique can be used as a method to characterize the degree of coherence of vortex beams. (paper)

  10. Self-Fourier functions and coherent laser combination

    International Nuclear Information System (INIS)

    Corcoran, C J; Pasch, K A

    2004-01-01

    The Gaussian and Comb functions are generally quoted as being the two basic functions that are their own Fourier transforms. In 1991, Caola presented a recipe for generating functions that are their own Fourier transforms by symmetrizing any transformable function and then adding its own Fourier transform to it. In this letter, we present a new method for generating a set of functions that are exactly their own Fourier transforms, and which have direct application to laser cavity design for a wide variety of applications. The generated set includes the Gaussian and Comb functions as special cases and forms a continuous bridge of functions between them. The new generating method uses the Gaussian and Comb functions as bases and does not rely on the Fourier operator itself. This self-Fourier function promises to be particularly useful in high-power laser design through coherent laser beam combination. Although these results are presented in a single dimension as with a linear array, the results are equally valid in two dimensions. (letter to the editor)

  11. Optical Ground Terminals Using Multi Aperture Digital Coherent Combining

    Science.gov (United States)

    2017-10-01

    advantages of a multi-aperture OGT are summarized in [4]. III. EXPERIMENTAL RESULTS A first experimental validation of multi-aperture digital coherent...Optical Ground Terminals Using Multi-Aperture Digital Coherent Combining (Invited Paper) D. J. Geisler, T. M. Yarnall, C. M. Schieler, M. L. Stevens...B. S. Robinson, and S. A. Hamilton Massachusetts Institute of Technology Lincoln Laboratory 244 Wood Street, Lexington, MA, USA 02420 Email

  12. Beam Combination for Sparse Aperture Telescopes Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal is for funding to continue development of an alternative beam combiner for Stellar Imager (SI), a 30-aperture, interferometric telescope chosen as one...

  13. Coherent hybrid electromagnetic field imaging

    Science.gov (United States)

    Cooke, Bradly J [Jemez Springs, NM; Guenther, David C [Los Alamos, NM

    2008-08-26

    An apparatus and corresponding method for coherent hybrid electromagnetic field imaging of a target, where an energy source is used to generate a propagating electromagnetic beam, an electromagnetic beam splitting means to split the beam into two or more coherently matched beams of about equal amplitude, and where the spatial and temporal self-coherence between each two or more coherently matched beams is preserved. Two or more differential modulation means are employed to modulate each two or more coherently matched beams with a time-varying polarization, frequency, phase, and amplitude signal. An electromagnetic beam combining means is used to coherently combine said two or more coherently matched beams into a coherent electromagnetic beam. One or more electromagnetic beam controlling means are used for collimating, guiding, or focusing the coherent electromagnetic beam. One or more apertures are used for transmitting and receiving the coherent electromagnetic beam to and from the target. A receiver is used that is capable of square-law detection of the coherent electromagnetic beam. A waveform generator is used that is capable of generation and control of time-varying polarization, frequency, phase, or amplitude modulation waveforms and sequences. A means of synchronizing time varying waveform is used between the energy source and the receiver. Finally, a means of displaying the images created by the interaction of the coherent electromagnetic beam with target is employed.

  14. 16 W output power by high-efficient spectral beam combining of DBR-tapered diode lasers

    DEFF Research Database (Denmark)

    Müller, André; Vijayakumar, Deepak; Jensen, Ole Bjarlin

    2011-01-01

    Up to 16 W output power has been obtained using spectral beam combining of two 1063 nm DBR-tapered diode lasers. Using a reflecting volume Bragg grating, a combining efficiency as high as 93.7% is achieved, resulting in a single beam with high spatial coherence. The result represents the highest...... output power achieved by spectral beam combining of two single element tapered diode lasers. Since spectral beam combining does not affect beam propagation parameters, M2-values of 1.8 (fast axis) and 3.3 (slow axis) match the M2- values of the laser with lowest spatial coherence. The principle...... of spectral beam combining used in our experiments can be expanded to combine more than two tapered diode lasers and hence it is expected that the output power may be increased even further in the future....

  15. 16 W output power by high-efficient spectral beam combining of DBR-tapered diode lasers.

    Science.gov (United States)

    Müller, André; Vijayakumar, Deepak; Jensen, Ole Bjarlin; Hasler, Karl-Heinz; Sumpf, Bernd; Erbert, Götz; Andersen, Peter E; Petersen, Paul Michael

    2011-01-17

    Up to 16 W output power has been obtained using spectral beam combining of two 1063 nm DBR-tapered diode lasers. Using a reflecting volume Bragg grating, a combining efficiency as high as 93.7% is achieved, resulting in a single beam with high spatial coherence. The result represents the highest output power achieved by spectral beam combining of two single element tapered diode lasers. Since spectral beam combining does not affect beam propagation parameters, M2-values of 1.8 (fast axis) and 3.3 (slow axis) match the M2-values of the laser with lowest spatial coherence. The principle of spectral beam combining used in our experiments can be expanded to combine more than two tapered diode lasers and hence it is expected that the output power may be increased even further in the future.

  16. Combined two-photon microscopy and angiographic optical coherence tomography

    Science.gov (United States)

    Kim, Bumju; Wang, Tae Jun; Li, Qingyun; Nam, Jutaek; Hwang, Sekyu; Chung, Euiheon; Kim, Sungjee; Kim, Ki Hean

    2013-08-01

    A combined two-photon microscopy (TPM) and angiographic optical coherence tomography (OCT) is developed, which can provide molecular, cellular, structural, and vascular information of tissue specimens in vivo. This combined system is implemented by adding an OCT vasculature visualization method to the previous combined TPM and OCT, and then is applied to in vivo tissue imaging. Two animal models, a mouse brain cranial window model and a mouse ear cancer model, are used. Both molecular, cellular information at local regions of tissues, and structural, vascular information at relatively larger regions are visualized in the same sections. In vivo tissue microenvironments are better elucidated by the combined TPM and angiographic OCT.

  17. High energy high intensity coherent photon beam for the SSC

    International Nuclear Information System (INIS)

    Tannenbaum, M.J.

    1984-01-01

    What is proposed for the 20 TeV protons hitting a fixed target is to make a tertiary electron beam similar to that which is the basis of the tagged photon beam at Fermilab. Briefly, a zero degree neutral beam is formed by sweeping out the primary proton beam and any secondary charged particles. Then the photons, from the decay of π 0 in the neutral beam, are converted to e + e - pairs in a lead converter and a high quality electron beam is formed. This beam is brought to the target area where it is converted to a photon beam by Bremsstrahlung in a radiator

  18. Generation of complete coherence in Young's interference experiment with random mutually uncorrelated electromagnetic beams

    NARCIS (Netherlands)

    Agarwal, G. S.; Dogariu, A.; Visser, T.D.; Wolf, E.

    2005-01-01

    The recently developed theory that unifies the treatments of polarization and coherence of random electro-magnetic beams is applied to study field correlations in Young's interference experiment. It is found that at certain pairs of points the transmitted field is spatially fully coherent,

  19. Free-space laser communication using a partially coherent source beam

    Science.gov (United States)

    Ricklin, Jennifer C.

    2002-01-01

    Free-space laser communication offers an attractive alternative for transferring high-bandwidth data when fiber optic cable is neither practical nor feasible. However, random fluctuations in the atmosphere's refractive index can severely degrade the signal-carrying laser beam, causing intensity fading at the receiver and increased system bit error rates. There is growing interest in developing techniques to overcome the turbulence-induced intensity fades that cause these bit error rates. It is shown here that using a partially coherent laser beam in a free-space laser communication system reduces system bit error rates by decreasing irradiance scintillations in the receiver focal plane. A partially coherent laser beam can be easily created by the placement of a phase diffuser in front of the transmitting aperture. The properties of a partially coherent laser beam are studied using a derived analytic expression for the cross-spectral density function of a partially coherent, quasi-monochromatic Gaussian laser beam propagating through atmospheric turbulence. This expression allows for the focusing or diverging characteristics of the laser beam. The beam size, average intensity phase front radius of curvature, and coherence properties of the partially coherent signal-carrying laser beam at the receiver are derived from the cross-spectral density function. The effect of receiver aperture averaging in reducing intensity scintillations for Gaussian beams of any degree of coherence is studied. An analytic expression is derived for the spatial covariance of irradiance fluctuations for a partially coherent Gaussian beam, subject to the restriction that the atmospheric turbulence-corrupted laser beam can be described as a Gaussian stochastic process. In the weak fluctuation regime this analytic expression is found to compare reasonably well with published data. A model is described for a free-space laser communication system comprised of a laser transmitter with a phase

  20. Spectral Coherence Along a Lidar-Anemometer Beam

    DEFF Research Database (Denmark)

    Kristensen, Leif; Kirkegaard, Peter; Mann, Jakob

    The theory of measuring the spectral coherence by means of a lidar anemometer has been outlined. It is based on the assumption that the turbulent velocity field can be considered statistically locally isotropic and on the validity of Taylor’s hypothesis. This implies that the longitudinal coherence...

  1. Passive cavity laser and tilted wave laser for Bessel-like beam coherently coupled bars and stacks

    Science.gov (United States)

    Ledentsov, N. N.; Shchukin, V. A.; Maximov, M. V.; Gordeev, N. Y.; Kaluzhniy, N. A.; Mintairov, S. A.; Payusov, A. S.; Shernyakov, Yu. M.; Vashanova, K. A.; Kulagina, M. M.; Schmidt, N. Y.

    2015-03-01

    Ultralarge output apertures of semiconductor gain chips facilitate novel applications that require efficient feedback of the reflected laser light. Thick (10-30 μm) and ultrabroad (>1000 μm) waveguides are suitable for coherent coupling through both near-field of the neighboring stripes in a laser bar and by applying external cavities. As a result direct laser diodes may become suitable as high-power high-brightness coherent light sources. Passive cavity laser is based on the idea of placing the active media outside of the main waveguide, for example in the cladding layers attached to the waveguide, or, as in the case of the Tilted Wave Laser (TWL) in a thin waveguide coupled to the neighboring thick waveguide wherein most of the field intensity is localized in the broad waveguide. Multimode or a single vertical mode lasing is possible depending on the coupling efficiency. We demonstrate that 1060 nm GaAs/GaAlAs-based Tilted Wave Lasers (TWL) show wall-plug efficiency up to ~55% with the power concentrated in the two symmetric vertical beams having a full width at half maximum (FWHM) of 2 degrees each. Bars with pitch sizes in the range of 25-400 μm are studied and coherent operation of the bars is manifested with the lateral far field lobes as narrow as 0.1° FWHM. As the near field of such lasers in the vertical direction represents a strongly modulated highly periodic pattern of intensity maxima such lasers or laser arrays generate Bessel-type beams. These beams are focusable similar to the case of Gaussian beams. However, opposite to the Gaussian beams, such beams are self-healing and quasi non-divergent. Previously Bessel beams were generated using Gaussian beams in combination with an axicon lens or a Fresnel biprism. A new approach does not involve such complexity and a novel generation of laser diodes evolves.

  2. A Monte Carlo approach for simulating the propagation of partially coherent x-ray beams

    DEFF Research Database (Denmark)

    Prodi, A.; Bergbäck Knudsen, Erik; Willendrup, Peter Kjær

    2011-01-01

    by sampling Huygens-Fresnel waves with Monte Carlo methods and is used to propagate each source realization to the detector plane. The sampling is implemented with a modified Monte Carlo ray tracing scheme where the optical path of each generated ray is stored. Such information is then used in the summation...... coherence function (MCF) are propagated to the exit plane. Here we present an approach based on Monte Carlo sampling of the Green function. A Gauss-Shell Stochastic Source with arbitrary spatial coherence is synthesized by means of the Gaussian copula statistical tool. The Green function is obtained......Advances at SR sources in the generation of nanofocused beams with a high degree of transverse coherence call for effective techniques to simulate the propagation of partially coherent X-ray beams through complex optical systems in order to characterize how coherence properties such as the mutual...

  3. Some fundamental aspects of fluctuations and coherence in charged-particle beams in storage rings

    International Nuclear Information System (INIS)

    Chattopadhyay, S.

    1984-01-01

    A conceptual survey and exposition is presented of some fundamental aspects of fluctuations and coherence, as well as the interplay between the two, in coasting charged-particle beams - both continuous and bunched - in storage rings. A detailed study is given of the spectral properties of the incoherent phase-space Schottky fluctuations, their propagation as waves in the beam, and the analytic complex coherent beam electromagnetic response or transfer function. The modification or distortion of these by collective interactions is examined in terms of simple regeneration mechanisms. Collective or coherent forces in the beam-storage-ring system are described by defining suitable impedance functions or propagators, and a brief discussion of the coherent collective modes and their stability is provided, including a general and rigorous description of the Nyquist stability criterion. The nature of the critical fluctuations near an instability threshold is explored. The concept of Landau damping and its connection with phase-mixing within the beam is outlined. The important connection between the incoherent fluctuations and the beam response, namely the Fluctuation-Dissipation relation, is revealed. A brief discussion is given of the information degrees of freedom, and effective temperature of the fluctuation signals. Appendices provide a short resume of some general aspects of various interactions in a charged-particle beam-environment system in a storage ring and a general introduction to kinetic theory as applied to particle beams. (orig.)

  4. Coherent undulator radiation of electron beam, microbunched for the FEL power outcoupling

    Energy Technology Data Exchange (ETDEWEB)

    Kulipanov, G.N.; Sokolov, A.S.; Vinokurov, N.A. [Budker Institute of Nuclear Physics, Novosibirsk (Russian Federation)

    1995-12-31

    The spectral intensity of the coherent undulator radiation of electron beam, preliminarily microbunched by the FEL oscillator for the FEL power outcoupling, is approximately calculated by simple analytic considerations, taking into account the transverse emittances and the energy spread of the microbunched electron beams.

  5. Vortex phase-induced changes of the statistical properties of a partially coherent radially polarized beam.

    Science.gov (United States)

    Guo, Lina; Chen, Yahong; Liu, Xianlong; Liu, Lin; Cai, Yangjian

    2016-06-27

    Partially coherent radially polarized (PCRP) beam was introduced and generated in recent years. In this paper, we investigate the statistical properties of a PCRP beam embedded with a vortex phase (i.e., PCRP vortex beam). We derive the analytical formula for the cross-spectral density matrix of a PCRP vortex beam propagating through a paraxial ABCD optical system and analyze the statistical properties of a PCRP vortex beam focused by a thin lens. It is found that the statistical properties of a PCRP vortex beam on propagation are much different from those of a PCRP beam. The vortex phase induces not only the rotation of the beam spot, but also the changes of the beam shape, the degree of polarization and the state of polarization. We also find that the vortex phase plays a role of resisting the coherence-induced degradation of the intensity distribution and the coherence-induced depolarization. Furthermore, we report experimental generation of a PCRP vortex beam for the first time. Our results will be useful for trapping and rotating particles, free-space optical communications and detection of phase object.

  6. Spectral beam combining of diode lasers with high efficiency

    DEFF Research Database (Denmark)

    Müller, André; Vijayakumar, Deepak; Jensen, Ole Bjarlin

    2012-01-01

    Based on spectral beam combining we obtain 16 W of output power, combining two 1063 nm DBR-tapered diode lasers. The spectral separation within the combined beam can be used for subsequent sum-frequency generation.......Based on spectral beam combining we obtain 16 W of output power, combining two 1063 nm DBR-tapered diode lasers. The spectral separation within the combined beam can be used for subsequent sum-frequency generation....

  7. Retrieving of the complex degree of spatial coherence of electron beams

    International Nuclear Information System (INIS)

    Carrasquilla-Alvarez, J.; Castaneda, R.; Garcia-Sucerquia, J.; Schofield, M.; Blegiia, M.; Matteucci, G.

    2005-10-01

    We discuss the applicability of a recently developed method for two-dimensionally retrieving the complex degree of spatial coherence of laser beams, in both amplitude and phase, to the case of the electron beam provided by the source of an electron microscope. Obtaining an electron beam with the highest possible coherence is critical for successful holography experiments. Therefore, the accurate measurement of the complex degree of spatial coherence is highly desirable. The method consists of the following three steps: recording of the beam spot, determining its centered-reduced moments and inserting them as coefficients of a series. This procedure is simple, fast and of higher performance than conventional procedures such Fourier analysis or Young interferometry. Experimental results are presented. (author)

  8. Enhanced coherent undulator radiation from bunched electron beams

    International Nuclear Information System (INIS)

    Berryman, K.W.; Crosson, E.R.; Ricci, K.N.; Smith, T.I.

    1996-01-01

    When energetic bunches of electrons traverse an undulator field, they can spontaneously emit radiation both coherently and incoherently. Although it has generally been assumed that undulator radiation is incoherent at wavelengths short compared to the longitudinal size of the electron bunch, several recent observations have proved this assumption false. Furthermore, the appearance of coherent radiation is often accompanied by a significant increase in radiated power. Here we report observations of strongly enhanced coherent spontaneous radiation together with direct measurements, using transition radiation techniques, of the electron distributions responsible for the coherent emission. We also report demonstrated enhancements in the predicted spontaneous radiated power by as much as 6x10 4 using electron bunch compression. copyright 1996 American Institute of Physics

  9. Coherent spontaneous radiation from highly bunched electron beams

    International Nuclear Information System (INIS)

    Berryman, K.W.; Crosson, E.R.; Ricci, K.N.

    1995-01-01

    Coherent spontaneous radiation has now been observed in several FELs, and is a subject of great importance to the design of self-amplified spontaneous emission (SASE) devices. We report observations of coherent spontaneous radiation in both FIREFLY and the mid-infrared FEL at the Stanford Picosecond FEL Center. Coherent emission has been observed at wavelengths as short as 5 microns, and enhancement over incoherent levels by as much as a factor of 4x10 4 has been observed at longer wavelengths. The latter behavior was observed at 45 microns in FIREFLY with short bunches produced by off-peak acceleration and dispersive compression. We present temporal measurements of the highly bunched electron distributions responsible for the large enhancements, using both transition radiation and energy-phase techniques

  10. Parallel simulations of partially coherent wavefront propagation from a finite emittance electron beam

    Science.gov (United States)

    Laundy, D.; Sutter, J. P.; Wagner, U. H.; Rau, C.; Thomas, C. A.; Sawhney, K. J. S.; Chubar, O.

    2013-03-01

    Hard X-ray undulator radiation at 3rd generation storage rings falls between the geometrical and the fully coherent limit. This is a result of the small but finite emittance of the electron beam source and means that the radiation cannot be completely modelled by incoherent ray tracing or by fully coherent wave propagation. We have developed using the wavefront propagation code Synchrotron Radiation Workshop (SRW) running in a Python environment, a parallel computer program using the Monte Carlo method for modelling the partially coherent emission from electron beam sources taking into account the finite emittance of the source. Using a parallel computing cluster with in excess of 500 cores and each core calculating the wavefront from in excess of a 1000 electrons, a source containing millions of electrons could be simulated. We have applied this method to the Diamond X-ray Imaging and Coherence beamline (113).

  11. Mutually incoherent beam combining through optical parametric amplification

    International Nuclear Information System (INIS)

    Tropheme, B.

    2012-01-01

    This work deals with a technique of combination of coherent beams: Optical Parametric Amplification (OPA) with Multiple Pumps. This technique is used to instantly transfer the energy of several pumps on one beam, without energy storage and thus avoiding thermal effects in the amplifying media. It can be useful to combine energy of numerous fiber lasers and to amplify with a high repetition rate very high energy lasers or broadband pulses. With a numerical and experimental study using BBO and LBO as nonlinear crystal, we determine how to dispose the pumps around the signal and the corresponding angular tolerances of such set up. Then we focus our attention on recombining mechanisms between a pump and a non-corresponding idler. We demonstrate experimentally that these cascading effects may decrease the spatial and spectral quality of the amplified signal, and that these phenomena can be avoided with a minimum angle between the different pumps. A novel modelling of multi-pumps OPA links these cascading effects to the gratings generated by the interaction between the pumps. The last part presents a 5 pump OPA experiment. We achieve a pump-to-signal efficiency of 27% and so that a signal more powerful than each pump is obtained. (author) [fr

  12. Damping of coherent oscillations in intense ion beams

    International Nuclear Information System (INIS)

    Karpov, Ivan

    2017-01-01

    Transverse decoherence of a displaced ion bunch is an important phenomenon in synchrotrons and storage rings. An offset can be caused by an injection error after the bunch-to-bucket transfer between synchrotrons or by an externally generated kick. Decoherence results in a transverse emittance blowup, which can cause particle losses and a beam quality degradation. To prevent the beam blowup, a transverse feedback system (TFS) can be used. The damping time should be shorter than the characteristic decoherence time, which can be strongly affected by the interplay of different intensity effects (e.g., space charge and impedances). This thesis describes the development of the analytical models that explain decoherence and emittance growth with chromaticity, space charge, and image charges within the first synchrotron period. The pulsed response function including intensity effects was derived from the model for beam transfer functions. For a coasting beam, the two- dimensional model shows that space charge slows down and above intensity threshold suppresses decoherence. These predictions were confirmed by particle tracking simulations with self-consistent space charge fields. Additionally, halo buildup and losses during decoherence were observed in simulations. These effects were successfully interpreted using a non self-consistent particle-core model. The two-dimensional model was extended to the bunched beams. The simulation results reproduce the analytical predictions. The intensity threshold of decoherence suppression is higher in comparison to a coasting beam, image charges can restore decoherence. In the present work dedicated experiments were performed in the SIS18 synchrotron at GSI Darmstadt and the results were compared with simulations and analytical predictions. The contribution of nonlinearities and image charges is negligible while chromaticity and space charge dominate decoherence. To study the damping efficiency of TFS, a comprehensive TFS module was

  13. Bipartite and tripartite entanglement of truncated harmonic oscillator coherent states via beam splitters

    Science.gov (United States)

    Daoud, M.; Jellal, A.; Choubabi, E. B.; El Kinani, E. H.

    2011-08-01

    We introduce a special class of truncated Weyl-Heisenberg algebra and discuss the corresponding Hilbertian and analytical representations. Subsequently, we study the effect of a quantum network of beam splitting on coherent states of this nonlinear class of harmonic oscillators. We particularly focus on quantum networks involving one and two beam splitters and examine the degree of bipartite as well as tripartite entanglement using the linear entropy.

  14. Bipartite and Tripartite Entanglement of Truncated Harmonic Oscillator Coherent States via Beam Splitters

    OpenAIRE

    Daoud, M.; Jellal, A.; Choubabi, E. B.; Kinani, E. H. El

    2012-01-01

    We introduce a special class of truncated Weyl-Heisenberg algebra and discuss the corresponding Hilbertian and analytical representations. Subsequently, we study the effect of a quantum network of beam splitting on coherent states of this nonlinear class of harmonic oscillators. We particularly focus on quantum networks involving one and two beam splitters and examine the degree of bipartite as well as tripartite entanglement using the linear entropy.

  15. Spatial and spectral coherence in propagating high-intensity twin beams

    Czech Academy of Sciences Publication Activity Database

    Haderka, O.; Machulka, R.; Peřina ml., Jan; Allevi, A.; Bondani, M.

    2015-01-01

    Roč. 5, Sep (2015), s. 14365 ISSN 2045-2322 R&D Projects: GA ČR GAP205/12/0382 Institutional support: RVO:68378271 Keywords : spatial and spectral coherence * high-intensity twin beams Subject RIV: BH - Optics, Masers, Lasers Impact factor: 5.228, year: 2015

  16. Pixel-Tilecal-MDT Combined Test Beam

    CERN Multimedia

    B. Di Girolamo

    A test with many expectations When an additional week of running (from September 11th to 18th) was allocated for the test-beam, it was decided to give priority to a combined run with the participation of the Pixel, Tilecal and MDT sub-detectors. The integration of these three sub-detectors was possible as they all use the baseline (DAQ-1/EF based) DAQ for test beams (as reported in a previous e-news). The tests and the addition of a common trigger and busy were organized in a short timescale by experts from the three sub-detectors and DAQ/EF. The expectations were many; both looking for problems and finding solutions. The setup The setup, shown in the figure, consisted of the Pixel telescope normally used during the sub-detector tests, two Tilecal barrel modules, two Tilecal extended barrel modules, and six MDT barrel chambers. This fully occupied a length of some 30 meters in the H8 line of the SPS North Area. Each sub-detector used their own specialized front-end electronics. The data collected by modu...

  17. Coherent production of {epsilon}{sup +} particles in crystal using proton beam from SSC

    Energy Technology Data Exchange (ETDEWEB)

    Okorokov, V.V.; Dubin, A.Yu. [ITER, Moscow, (Russian Federation)

    1995-05-01

    The unique possibilities of the SSC can be ideally used for a new generation of coherent generation experiments with relativistic protons which require 20 Tev energy of the incident beam. The availability of 20 Tev proton beam at SSC allows new experiments on coherent production of {var_epsilon}{sup +} particle by relativistic proton in crystal. Experiment carried out at low energies can now be extended with protons in very narrow energy region (resonance energy, which easy can be calculated) using the new accelerator facilities at SSC. We propose to study coherent production via the Coulomb field of the cristal atoms to excite the transition p + {gamma}{implies} {var_epsilon} {sup +} (1189).

  18. The 2004 ATLAS Combined Test Beam

    CERN Multimedia

    The ATLAS CTB Team, .

    2004-01-01

    In the year 2004, ATLAS has been involved in a huge combined test beam (CTB) effort in H8. A complete slice of the barrel detector and of the Muon End-cap has been tested, with the following clear goals: pre-commission the final elements and study the detector performance in a realistic combined data taking. Thanks to this experience, a lot of expertise in the operations has been acquired and much data (~ 4.6 TB of data, ~ 90 million events on castor) has been collected and is already under analysis. The CTB has been characterized by different phases with an incremental presence of sub-detectors modules and associated DAQ infrastructure, as well as incremental improvement of analysis tools for prompt data certification. The physics goals of the CTB have been defined in consultation with the physics coordinator, all the sub-detector representatives and the combined performance group representative. With all these indications, a detailed run plan day-by-day schedule was defined before the CTB start and was foll...

  19. Mitigating effect on turbulent scintillation using non-coherent multi-beam overlapped illumination

    Science.gov (United States)

    Zhou, Lu; Tian, Yuzhen; Wang, Rui; Wang, Tingfeng; Sun, Tao; Wang, Canjin; Yang, Xiaotian

    2017-12-01

    In order to find an effective method to mitigate the turbulent scintillation for applications involved laser propagation through atmosphere, we demonstrated one model using non-coherent multi-beam overlapped illumination. Based on lognormal distribution and the statistical moments of overlapped field, the reduction effect on turbulent scintillation of this method was discussed and tested against numerical wave optics simulation and laboratory experiments with phase plates. Our analysis showed that the best mitigating effect, the scintillation index of overlapped field reduced to 1/N of that when using single beam illuminating, could be obtained using this method when the intensity of N emitting beams equaled to each other.

  20. Coherent and non coherent atom optics experiment with an ultra-narrow beam of metastable rare gas atoms

    International Nuclear Information System (INIS)

    Grucker, J.

    2007-12-01

    In this thesis, we present a new type of atomic source: an ultra-narrow beam of metastable atoms produced by resonant metastability exchange inside a supersonic beam of rare gas atoms. We used the coherence properties of this beam to observe the diffraction of metastable helium, argon and neon atoms by a nano-transmission grating and by micro-reflection-gratings. Then, we evidenced transitions between Zeeman sublevels of neon metastable 3 P 2 state due to the quadrupolar part of Van der Waals potential. After we showed experimental proofs of the observation of this phenomenon, we calculated the transition probabilities in the Landau - Zener model. We discussed the interest of Van der Waals - Zeeman transitions for atom interferometry. Last, we described the Zeeman cooling of the supersonic metastable argon beam ( 3 P 2 ). We have succeeded in slowing down atoms to speeds below 100 m/s. We gave experimental details and showed the first time-of-flight measurements of slowed atoms

  1. High-precision beam shaper for coherent and incoherent light using a DLP spatial light modulator

    Science.gov (United States)

    Liang, Jinyang; Kohn, Rudolph N., Jr.; Becker, Michael F.; Heinzen, Daniel J.

    2011-03-01

    We designed a precision laser beam shaper using a Texas Instruments digital micromirror device (DMD) with a telescope system containing a pinhole low-pass filter. The performance of the beam shaper was measured by comparing the intensity and wave-front uniformity to the target function and by the energy conversion efficiency. We demonstrated flattop and other laser beam profiles with 1-1.5% root-mean-square (RMS) error for a raw camera image and nearly flat phase. A noise analysis of the system revealed that lower error is possible and that most of the error came from coherent speckle noise in the camera. A previous experiment using a 1064 nm single-mode fiber (SMF) laser produced around 7% beam power conversion efficiency. Here we report improvements in system automation and laser source flexibility that result in increasing both the speed of the system to calculate and produce a beam, and the beam uniformity and energy conversion efficiency. A LabVIEW program was written to accelerate the speed of the iterative process for beam profile refinement. A 760 nm super-luminescent light emitting diode (SLED) and a 781 nm Laser Diode (LD) were used as light sources in order to reduce the beam coherence and approach the ultimate performance of the shaper. Both sources greatly reduced the speckle noise and increased measured intensity uniformity. Experiments achieved less than 0.9% RMS error over the entire flattop area with a diameter of 1.32 mm. In addition, simulations were conducted to determine the optimized wavelengths for different types of DMDs. For the .7XGA DMD, the 5th diffraction order matches 750-800 nm. Matching the laser diode to this wavelength increased the power conversion efficiency (input beam to output beam) to 19.8%.

  2. Test Beam Coordination: 2003 ATLAS Combined Test Beam

    CERN Multimedia

    Di Girolamo, B.

    The 2003 Test Beam Period The 2003 Test Beam period has been very fruitful for ATLAS. In spite of several days lost because of the accelerator problems, ATLAS has been able to achieve many results: FCAL has completed the calibration program in H6 Tilecal has completed the calibration program in H8 Pixel has performed extensive studies with normal and high intensity beams (up to 1.4*108 hadrons/spill) SCT has completed a variety of studies with quite a high number of modules operated concurrently TRT has performed several studies at high, low and very low energy (first use of the new H8 beam in the range 1 to 9 GeV) Muons (MDT,RPC and TGC) have been operating a large setup for about 5 months. The almost final MDT ROD (MROD) has been integrated in the readout and the final trigger electronics for TGC and RPC has been tested and certified with normal beam and during dedicated 40 MHz beam periods. The TDAQ has exploited a new generation prototype successfully and the new Event Filter infrastructure f...

  3. Experimental studies on coherent synchrotron radiation at an emittance exchange beam line

    Directory of Open Access Journals (Sweden)

    J. C. T. Thangaraj

    2012-11-01

    Full Text Available One of the goals of the Fermilab A0 photoinjector is to investigate experimentally the transverse to longitudinal emittance exchange (EEX principle. Coherent synchrotron radiation in the emittance exchange line could limit the performance of the emittance exchanger at short bunch lengths. In this paper, we present experimental and simulation studies of the coherent synchrotron radiation (CSR in the emittance exchange line at the A0 photoinjector. We report on time-resolved CSR studies using a skew-quadrupole technique. We also demonstrate the advantages of running the EEX with an energy-chirped beam.

  4. Polarization-beam-splitter-less integrated dual-polarization coherent receiver.

    Science.gov (United States)

    Alonso-Ramos, C; Reyes-Iglesias, P J; Ortega-Moñux, A; Pérez-Galacho, D; Halir, R; Molina-Fernández, I

    2014-08-01

    Conventional dual-polarization coherent receivers require polarization beam splitters for either the signal or the local oscillator path. This severely hinders monolithic integration, since integrated polarization splitting devices often exhibit stringent fabrication tolerances. Here we propose a dual-polarization monolithically integrated coherent receiver architecture that completely avoids the use of polarization splitting elements. Polarization management is instead achieved by adequately engineering the birefringence of the interconnecting waveguides. The resultant receiver is highly tolerant to fabrication deviations and thus offers a completely new route for monolithic integration of dual-polarization receivers without any type of active tuning.

  5. Geometric considerations of polar mesospheric summer echoes in tilted beams using coherent radar imaging

    Science.gov (United States)

    Sommer, S.; Stober, G.; Chau, J. L.; Latteck, R.

    2014-11-01

    We present observations of polar mesospheric summer echoes (PMSE) using the Middle Atmosphere Alomar Radar System in Northern Norway (69.30° N, 16.04° E). The radar is able to resolve PMSE at high spatial and temporal resolution and to perform pulse-to-pulse beam steering. In this experiment, 81 oblique beam directions were used with off-zenith angles up to 25°. For each beam pointing direction and range gate, coherent radar imaging was applied to determine the mean backscatter location. The location of the mean scatterer in the beam volume was calculated by the deviation from the nominal off-zenith angle of the brightest pixel. It shows that in tilted beams with an off-zenith angle greater than 5°, structures appear at the altitudinal edges of the PMSE layer. Our results indicate that the mean influence of the location of the maximum depends on the tilt of the beam and on the observed area of the PMSE layer. At the upper/lower edge of the PMSE layer, the mean backscatter has a greater/smaller off-zenith angle than the nominal off-zenith angle. This effect intensifies with greater off-zenith beam pointing direction, so the beam filling factor plays an important role in the observation of PMSE layers for oblique beams.

  6. Much Ado about Microbunching: Coherent Bunching in High Brightness Electron Beams

    Energy Technology Data Exchange (ETDEWEB)

    Ratner, Daniel [Stanford Univ., CA (United States)

    2011-05-01

    The push to provide ever brighter coherent radiation sources has led to the creation of correspondingly bright electron beams. With billions of electrons packed into normalized emittances (phase space) below one micron, collective effects may dominate both the preservation and use of such ultra-bright beams. An important class of collective effects is due to density modulations within the bunch, or microbunching. Microbunching may be deleterious, as in the case of the Microbunching Instability (MBI), or it may drive radiation sources of unprecedented intensity, as in the case of Free Electron Lasers (FELs). In this work we begin by describing models of microbunching due to inherent beam shot noise, which sparks both the MBI as well as SLAC's Linac Coherent Light Source, the world's first hard X-ray laser. We first use this model to propose a mechanism for reducing the inherent beam shot noise as well as for predicting MBI effects. We then describe experimental measurements of the resulting microbunching at LCLS, including optical radiation from the MBI, as well as the first gain length and harmonic measurements from a hard X-ray FEL. In the final chapters, we describe schemes that use external laser modulations to microbunch light sources of the future. In these sections we describe coherent light source schemes for both both linacs and storage rings.

  7. Coherent control of high efficiency metasurface beam deflectors with a back partial reflector

    Directory of Open Access Journals (Sweden)

    Shota Kita

    2017-04-01

    Full Text Available Recently, coherent control of absorption in metallic metasurfaces has been demonstrated, and this phenomenon was applied to intriguing light-by-light switching operation. Here we experimentally demonstrate coherent control of beam deflection by high-efficiency metasurfaces for the first time. Although the beam deflection efficiency by a metasurface is generally small, high-efficiency metasurfaces, which consist of a single layer metasurface with a back reflector, are known to exhibit significantly high deflection efficiency. A key point of our study is to replace the back reflector with a partial reflector instead, which enables light-by-light control of a high-efficiency metasurface with a pair of counter-propagating coherent beam inputs. By adjusting the partial reflector thickness appropriately, the proposed device outperforms ones without a reflector, especially for the deflection efficiency. We finally experimentally demonstrate the expected operation of the fabricated device at a visible wavelength, which reveals that the deflection efficiency of 45% (49% in theory. This result demonstrates highly efficient light-by-light control of the beam deflection by a metasurface, which opens up possible applications to ultrathin photonic devices for linear all-optical switching and logic functions.

  8. Combined phenomena of beam-beam and beam-electron cloud interactionsin circular e^{+}e^{-} colliders

    Directory of Open Access Journals (Sweden)

    Kazuhito Ohmi

    2002-10-01

    Full Text Available An electron cloud causes various effects in high intensity positron storage rings. The positron beam and the electron cloud can be considered a typical two-stream system with a certain plasma frequency. Beam-beam interaction is another important effect for high luminosity circular colliders. Colliding two beams can be considered as a two-stream system with another plasma frequency. We study the combined phenomena of the beam-electron cloud and beam-beam interactions from a viewpoint of two complex two-stream effects with two plasma frequencies.

  9. Quantum coherent tractor beam effect for atoms trapped near a nanowaveguide

    Science.gov (United States)

    Sadgrove, Mark; Wimberger, Sandro; Nic Chormaic, Síle

    2016-01-01

    We propose several schemes to realize a tractor beam effect for ultracold atoms in the vicinity of a few-mode nanowaveguide. Atoms trapped near the waveguide are transported in a direction opposite to the guided mode propagation direction. We analyse three specific examples for ultracold 23Na atoms trapped near a specific nanowaveguide (i.e. an optical nanofibre): (i) a conveyor belt-type tractor beam effect, (ii) an accelerator tractor beam effect, and (iii) a quantum coherent tractor beam effect, all of which can effectively pull atoms along the nanofibre toward the light source. This technique provides a new tool for controlling the motion of particles near nanowaveguides with potential applications in the study of particle transport and binding as well as atom interferometry. PMID:27440516

  10. Energy harvesting from coherent resonance of horizontal vibration of beam excited by vertical base motion

    Energy Technology Data Exchange (ETDEWEB)

    Lan, C. B.; Qin, W. Y. [Department of Engineering Mechanics, Northwestern Polytechnical University, Xi' an 710072 (China)

    2014-09-15

    This letter investigates the energy harvesting from the horizontal coherent resonance of a vertical cantilever beam subjected to the vertical base excitation. The potential energy of the system has two symmetric potential wells. So, under vertical excitation, the system can jump between two potential wells, which will lead to the large vibration in horizontal direction. Two piezoelectric patches are pasted to harvest the energy. From experiment, it is found that the vertical excitation can make the beam turn to be bistable. The system can transform vertical vibration into horizontal vibration of low frequency when excited by harmonic motion. The horizontal coherence resonance can be observed when excited by a vertical white noise. The corresponding output voltages of piezoelectric films reach high values.

  11. The effect of nonlinear forces on coherently oscillating space-charge-dominated beams

    International Nuclear Information System (INIS)

    Celata, C.M.

    1987-03-01

    A particle-in-cell computer simulation code has been used to study the transverse dynamics of nonrelativistic misaligned space-charge-dominated coasting beams in an alternating gradient focusing channel. In the presence of nonlinear forces due to dodecapole or octupole imperfections of the focusing fields or to image forces, the transverse rms emittance grows in a beat pattern. Analysis indicates that this emittance dilution is due to the driving of coherent modes of the beam near their resonant frequencies by the nonlinear force. The effects of the dodecapole and images forces can be made to effectively cancel for some boundary conditions, but the mechanism is not understood at this time

  12. Coherent Combining of High-Power Yb Fiber Amplifiers

    Science.gov (United States)

    2011-04-20

    the power~in-the-bucket ( PIB ) vertical beam quality (VBQ) [J 5], which is a related to the fraction of the power within a given far-field angle...compared with a reference ideal beam (the ideal tophat in this case). The power-in- the-bucket ( PIB ) vertical beam quality (VBQ) [I 5] is given by (c/ay!ll

  13. Statistical signal processing techniques for coherent transversal beam dynamics in synchrotrons

    Energy Technology Data Exchange (ETDEWEB)

    Alhumaidi, Mouhammad

    2015-03-04

    Transversal coherent beam oscillations can occur in synchrotrons directly after injection due to errors in position and angle, which stem from inaccurate injection kicker reactions. Furthermore, the demand for higher beam intensities is always increasing in particle accelerators. The wake fields generated by the traveling particles will be increased by increasing the beam intensity. This leads to a stronger interaction between the beam and the different accelerator components, which increases the potential of coherent instabilities. Thus, undesired beam oscillations will occur when the natural damping is not enough to attenuate the oscillations generated by the coherent beam-accelerator interactions. The instabilities and oscillations can be either in transversal or longitudinal direction. In this work we are concerned with transversal beam oscillations only. In normal operation, transversal beam oscillations are undesired since they lead to beam quality deterioration and emittance blow up caused by the decoherence of the oscillating beam. This decoherence is caused by the tune spread of the beam particles. The emittance blow up reduces the luminosity of the beam, and thus the collision quality. Therefore, beam oscillations must be suppressed in order to maintain high beam quality during acceleration. A powerful way to mitigate coherent instabilities is to employ a feedback system. A Transversal Feedback System (TFS) senses instabilities of the beam by means of Pickups (PUs), and acts back on the beam through actuators, called kickers. In this thesis, a novel concept to use multiple PUs for estimating the beam displacement at the position with 90 phase advance before the kicker is proposed. The estimated values should be the driving feedback signal. The signals from the different PUs are delayed such that they correspond to the same bunch. Subsequently, a weighted sum of the delayed signals is suggested as an estimator of the feedback correction signal. The

  14. Effects of astigmatism on spectra, coherence and polarization of stochastic electromagnetic beams passing through an astigmatic optical system.

    Science.gov (United States)

    Pan, Liuzhan; Sun, Mengle; Ding, Chaoliang; Zhao, Zhiguo; Lü, Baida

    2009-04-27

    Analytical formulas for the cross-spectral density matrix of stochastic electromagnetic Gaussian Schell-model (EGSM) beams passing through an astigmatic optical system are derived. We show both analytically and by numerical examples the effects of astigmatism on spectra, coherence and polarization of stochastic electromagnetic EGSM beams propagating through an astigmatic lens. A comparison with the aberration-free case is made, and shows that the astigmatism has significant effect on the spectra, coherence and polarization.

  15. Electronic state alignment, orientation, and coherence produced by beam-foil collisions

    International Nuclear Information System (INIS)

    Church, D.A.

    1975-01-01

    The cylindrically symmetric beam-foil collision produces excitation and alignment of atom and ion levels similar, but not identical, to that resulting at comparable energies from ion-atom or ion-molecule collisions. When the foil is tilted, the macroscopic change acts on the microscopic scale to produce coherent alignment and orientation of the excited levels. The maximum beam energy range bounding this interaction has not yet been defined. The dynamic interaction which produces these effects is currently not predicted by any theory, although the dynamics of the ions subsequent to the collision are well understood. Refinement of current experimental technique can be expected to better define the final foil surface. The beam-tilted-foil collision promises to be useful in the study of ionic structure via quantum beat, radio-frequency and level-crossing spectroscopy techniques, and may provide a useful probe for certain surface interactions. 4 figs, 48 refs

  16. First measurements of subpicosecond electron beam structure by autocorrelation of coherent diffraction radiation

    CERN Document Server

    Lumpkin, Alex H; Rule, D W

    2001-01-01

    We report the initial measurements of subpicosecond electron beam structure using a nonintercepting technique based on the autocorrelation of coherent diffraction radiation (CDR). A far infrared (FIR) Michelson interferometer with a Golay detector was used to obtain the autocorrelation. The radiation was generated by a thermionic rf gun beam at 40 MeV as it passed through a 5-mm-tall slit/aperture in a metal screen whose surface was at 45 deg. to the beam direction. For the observed bunch lengths of about 450 fs (FWHM) with a shorter time spike on the leading edge, peak currents of about 100 A are indicated. Also a model was developed and used to calculate the CDR from the back of two metal strips separated by a 5-mm vertical gap. The demonstrated nonintercepting aspect of this method could allow on-line bunch length characterizations to be done during free-electron laser experiments.

  17. Concept of a tunable source of coherent THz radiation driven by a plasma modulated electron beam

    Science.gov (United States)

    Zhang, H.; Konoplev, I. V.; Doucas, G.; Smith, J.

    2018-04-01

    We have carried out numerical studies which consider the modulation of a picosecond long relativistic electron beam in a plasma channel and the generation of a micro-bunched train. The subsequent propagation of the micro-bunched beam in the vacuum area was also investigated. The same numerical model was then used to simulate the radiation arising from the interaction of the micro-bunched beam with a metallic grating. The dependence of the radiation spectrum on the parameters of the micro-bunched beam has been studied and the tunability of the radiation by the variation of the micro-bunch spacing has been demonstrated. The micro-bunch spacing can be changed easily by altering the plasma density without changing the beam energy or current. Using the results of these studies, we develop a conceptual design of a tunable source of coherent terahertz (THz) radiation driven by a plasma modulated beam. Such a source would be a potential and useful alternative to conventional vacuum THz tubes and THz free-electron laser sources.

  18. Strong reduction of the degree of spatial coherence of a laser beam propagating through a preformed plasma

    International Nuclear Information System (INIS)

    Michel, P.; Labaune, C.; Bandulet, H.C.; Michard, A.; Lewis, K.; Depierreux, S.; Hulin, S.; Bonnaud, G.; Tikhonchuk, V. T.; Weber, S.; Riazuelo, G.; Baldis, H.A.

    2004-01-01

    A strong reduction of the spatial coherence of a laser beam after its propagation through a plasma has been measured using a Fresnel biprism interferometer. The laser beam was diffraction limited; the coherence width was reduced from 40 mm in vacuum down to a few mm with the plasma. Numerical results based on a paraxial model exhibit a coherence degree close to the experimental one; they also prove the importance of taking into account the nonlocal transport effects in numerical simulations for such plasma conditions

  19. A plasma amplifier to combine multiple beams at NIF

    Science.gov (United States)

    Kirkwood, R. K.; Turnbull, D. P.; Chapman, T.; Wilks, S. C.; Rosen, M. D.; London, R. A.; Pickworth, L. A.; Colaitis, A.; Dunlop, W. H.; Poole, P.; Moody, J. D.; Strozzi, D. J.; Michel, P. A.; Divol, L.; Landen, O. L.; MacGowan, B. J.; Van Wonterghem, B. M.; Fournier, K. B.; Blue, B. E.

    2018-05-01

    Combining laser beams in a plasma is enabled by seeded stimulated Brillouin scattering which allows cross-beam energy transfer (CBET) to occur and re-distributes the energy between beams that cross with different incident angles and small differences in wavelength [Kirkwood et al. Phys. Plasmas 4, 1800 (1997)]. Indirect-drive implosions at the National Ignition Facility (NIF) [Haynam et al. Appl. Opt. 46, 3276-3303 (2007)] have controlled drive symmetry by using plasma amplifiers to transfer energy between beams [Kirkwood et al., Plasma Phys. Controlled Fusion 55, 103001 (2013); Lindl et al., Phys. Plasmas 21, 020501 (2014); and Hurricane et al. Nature 506, 343-348 (2014)]. In this work, we show that the existing models are well enough validated by experiments to allow a design of a plasma beam combiner that, once optimized, is expected to produce a pulse of light in a single beam with the energy greatly enhanced over existing sources. The scheme combines up to 61 NIF beams with 120 kJ of available energy into a single f/20 beam with a 1 ns pulse duration and a 351 nm wavelength by both resonant and off-resonance CBET. Initial experiments are also described that have already succeeded in producing a 4 kJ, 1 ns pulse in a single beam by combination of up to eight incident pump beams containing <1.1 kJ/beam, which are maintained near resonance for CBET in a plasma that is formed by 60 pre-heating beams [Kirkwood et al., Nat. Phys. 14, 80 (2018)].

  20. Characterization and mitigation of coherent-optical-transition-radiation signals from a compressed electron beam

    Directory of Open Access Journals (Sweden)

    A. H. Lumpkin

    2009-08-01

    Full Text Available The Advanced Photon Source (APS injector complex includes an option for rf photocathode (PC gun beam injection into the 450-MeV S-band linac. At the 150-MeV point, a four-dipole chicane was used to compress the micropulse bunch length from a few ps to sub-0.5 ps (FWHM. Noticeable enhancements of the optical transition radiation (OTR signal sampled after the APS chicane were then observed as has been reported in the Linac Coherent Light Source (LCLS injector commissioning. A far-infrared (FIR coherent transition radiation detector and interferometer were used to monitor the bunch compression process and correlate the appearance of localized spikes of OTR signal (5 to 10 times brighter than adjacent areas within the beam-image footprint. We have performed spectral-dependency measurements at 375 MeV with a series of bandpass filters centered in 50-nm increments from 400 to 700 nm and with an imaging spectrometer and observed a broadband enhancement in these spikes. Mitigation concepts of the observed coherent OTR, which exhibits an intensity enhancement in the red part of the visible spectrum as compared to incoherent OTR, are described.

  1. Beam profile and coherence properties of synchrotron beams after reflection on modified multilayer mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Rack, Alexander, E-mail: alexander.rack@esrf.fr; Vivo, Amparo; Morawe, Christian [European Synchrotron Radiation Facility (ESRF), BP 220, F-38043 Grenoble (France); Helfen, Lukas [European Synchrotron Radiation Facility (ESRF), BP 220, F-38043 Grenoble (France); ANKA light source, Karlsruhe Institute of Technology, PO Box 3640, D-76021 Karlsruhe (Germany)

    2016-07-27

    Multilayer mirrors present an attractive alternative for reflective hard X-ray monochromators due to their increased bandwidth compared with crystal-based systems. An issue remains the strong modulations in the reflected beam profile, i.e. an irregular stripe pattern. This is a major problem for micro-imaging applications, where multilayer-based monochromators are frequently employed to deliver higher photon flux density. A subject of particular interest is how to overcome beam profile modifications, namely the stripe patterns, induced by the reflection on a multilayer. For multilayer coatings in general it is known that the substrate and its surface quality significantly influence the performance of such kind of mirrors as the coating reproduces to a certain degree roughness and shape of the substrate. Our studies have shown that modified coatings can significantly change the impact of the multilayer reflection on the beam profile. We will present recent results as well as a critical review.

  2. New beam shaping: Matched filtering combined with GPC

    DEFF Research Database (Denmark)

    Glückstad, Jesper

    2010-01-01

    We adapt concepts frolll matched filtering 10 propose a method for generating rcconligurablc multiple beams. Combined with the Generalized Phase Contrast (GPC) technique, the proposed method coined mGPC can yield dynamically rcconfigurablc optical beam 31rdYS wilh high light efficiency for optica...

  3. Coherent multi-dimensional spectroscopy at optical frequencies in a single beam with optical readout

    Science.gov (United States)

    Seiler, Hélène; Palato, Samuel; Kambhampati, Patanjali

    2017-09-01

    Ultrafast coherent multi-dimensional spectroscopies form a powerful set of techniques to unravel complex processes, ranging from light-harvesting, chemical exchange in biological systems to many-body interactions in quantum-confined materials. Yet these spectroscopies remain complex to implement at the high frequencies of vibrational and electronic transitions, thereby limiting their widespread use. Here we demonstrate the feasibility of two-dimensional spectroscopy at optical frequencies in a single beam. Femtosecond optical pulses are spectrally broadened to a relevant bandwidth and subsequently shaped into phase coherent pulse trains. By suitably modulating the phases of the pulses within the beam, we show that it is possible to directly read out the relevant optical signals. This work shows that one needs neither complex beam geometries nor complex detection schemes in order to measure two-dimensional spectra at optical frequencies. Our setup provides not only a simplified experimental design over standard two-dimensional spectrometers but its optical readout also enables novel applications in microscopy.

  4. Experimental characterization of X-ray transverse coherence in the presence of beam transport optics

    DEFF Research Database (Denmark)

    Chubar, O.; Fluerasu, A.; Chu, Y.S.

    2013-01-01

    A simple Boron fiber based interference scheme [1] and other similar schemes are currently routinely used for X-ray coherence estimation at 3rd generation synchrotron radiation sources. If such a scheme is applied after a perfect monochromator and without any focusing / transport optics...... in the optical path, the interpretation of the measured interference pattern is relatively straightforward and can be done in terms of the basic parameters of the source [2]. However, if the interference scheme is used after some focusing optics, e.g. close to the X-ray beam waist, the visibility of fringes can...... propagation based simulations show, in particular, that new generation 1D Beryllium Compound Refractive Lenses [3, 4] do not reduce the X-ray transverse coherence in any significant manner....

  5. Modifications of the laser beam coherence inertial confinement fusion plasmas; Modifications des proprietes de coherence des faisceaux laser dans les plasmas de fusion par confinement inertiel

    Energy Technology Data Exchange (ETDEWEB)

    Grech, M

    2007-06-15

    Inertial confinement fusion by laser requires smoothed laser beam with well-controlled coherence properties. Such beams are made of many randomly distributed intensity maxima: the so-called speckles. As the laser beam propagates through plasma its temporal and spatial coherence can be reduced. This phenomenon is called plasma induced smoothing. For high laser intensities, instabilities developing independently inside the speckles are responsible for the coherence loss. At lower intensities, only collective effects, involving many speckles, can lead to induced smoothing. This thesis is a theoretical, numerical and experimental study of these mechanisms. Accounting for the partially incoherent behavior of the laser beams requires the use of statistical description of the laser-plasma interaction. A model is developed for the multiple scattering of the laser light on the self-induced density perturbations that is responsible for a spreading of the temporal and spatial spectra of the transmitted light. It also serves as a strong seed for the instability of forward stimulated Brillouin scattering that induces both, angular spreading and red-shift of the transmitted light. A statistical model is developed for this instability. A criterion is obtained that gives a laser power (below the critical power for filamentation) above which the instability growth is important. Numerical simulations with the interaction code PARAX and an experiment performed on the ALISE laser facility confirm the importance of these forward scattering mechanisms in the modification of the laser coherence properties. (author)

  6. Intensity and average orbital angular momentum of partially coherent flat-topped vortex beam in slant atmospheric turbulence

    Science.gov (United States)

    Li, Ya-qing; Wang, Li-guo

    2017-11-01

    On the basis of the extended Huygens-Fresnel principle and the cross-spectral density function (CSDF), the intensity and average orbital angular momentum (OAM) of the partially coherent flat-topped vortex beams in the slant atmospheric turbulence are presented. The effects of the order, topological charge, waist radius, and propagation distance of the beam on the intensity and average OAM are discussed. Results obtained show that the intensity of the partially coherent flat-topped vortex beam is changed due to the variations of the propagation distance, waist radius, topological charge and beam order, the average OAM is constant during the beam propagation in the atmospheric turbulence and related only to the waist radius and beam order. Results obtained by this paper may serve as theory bases for future applications in the atmospheric optical communication.

  7. Measurement of neutral current coherent neutral pion production on carbon in a few-GeV neutrino beam

    International Nuclear Information System (INIS)

    2010-01-01

    The SciBooNE Collaboration reports a measurement of neutral current coherent neutral pion production on carbon by a muon neutrino beam with average energy 0.8 GeV. The separation of coherent from inclusive neutral pion production has been improved by detecting recoil protons from resonant neutral pion production. We measure the ratio of the neutral current coherent neutral pion production to total charged current cross sections to be (1.16 +/- 0.24) x 10-2. The ratio of charged current coherent pion to neutral current coherent pion production is calculated to be 0.14+0.30 -0.28, using our published charged current coherent pion measurement.

  8. Effect of toroidal mirror on spatial coherence of synchrotron hard X-ray beams

    International Nuclear Information System (INIS)

    Wang Hua; Yan Shuai; Yan Fen; Mao Chengwen; Liang Dongxun; He Yan; Jiang Sheng; Li Aiguo; Yu Xiaohan

    2012-01-01

    The Gaussian Schell-model source theory is used to describe the hard X-ray micro focusing beamline with an undulator of the Shanghai Synchrotron Radiation Facility. Based on the model and general Huygens-Fresnel principle, propagation of cross-spectral density function in free space is studied. Equivalent source hypothesis is proposed and the effect of toroidal mirror on spatial coherence of the hard X-ray beams is studied. The theoretical results are consistent with the experimental results. Only divergence angles of the incident and outgoing X-rays are considered in the equivalent source hypothesis, hence an easy extension of the hypothesis to other beamline optical elements. (authors)

  9. A Novel Diagnostics of Ultrashort Electron Bunches Based on Detection of Coherent Radiation from Bunched Electron Beam in an Undulator

    CERN Document Server

    Saldin, Evgeny L; Yurkov, Mikhail V

    2004-01-01

    We propose a new method for measurements of the longitudinal profile of 100 femtosecond electron bunches for X-ray Free Electron Lasers (XFELs). The method is based on detection of coherent undulator radiation produced by modulated electron beam. Seed optical quantum laser is used to produce exact optical replica of ultrashort electron bunches. The replica is generated in apparatus which consists of an input undulator (energy modulator), and output undulator (radiator) separated by a dispersion section. The radiation in the output undulator is excited by the electron bunch modulated at the optical wavelength and rapidly reaches a hundred-MW-level power. We then use the now-standard method of ultrashort laser pulse-shape measurement, a tandem combination of autocorrelator and spectrum (FROG -- frequency resolved optical gating) providing real-time single-shot measurements of the electron bunch structure. The big advantage of proposed technique is that it can be used to determine the slice energy spread and emi...

  10. The impact of coherent synchrotron radiation on the beam transport of short bunches

    International Nuclear Information System (INIS)

    Li, R.

    1999-01-01

    Designs for next-generation accelerator, such as future linear colliders and short-wavelength FEL drivers, require beams of short (mm-length or smaller) bunches and high charge (nC-regime). As such a high charge microbunch traverses magnetic bends, the curvature effect on the bunch self-interaction, by way of coherent synchrotron radiation (CSR) and space charge force, may cause serious emittance degradation. This impact of CSR on the beam transport of short bunches has raised significant concern in the design of future machines and led to extensive investigations. This paper reviews some of the recent progress in the understanding of the CSR effect, presents analysis of and computational work on the CSR impact on short bunch transport, and addresses remaining issues

  11. Impact of coherent synchrotron radiation on beam qualities in a Chicane

    International Nuclear Information System (INIS)

    Xiang Dao; Huang Wenhui; He Xiaozhong

    2004-01-01

    When the bunch goes through a Chicane, the energy will be redistributed within the bunch due to CSR (coherent synchrotron radiation), which would cause nonlinearity. Present theory states that this nonlinearity would add a huge amount to emittance growth. Based on simulation results, this paper would point out that the theory is only valid under an ideal condition that the bunch initially has no nonlinearity and under some given parameters there could be a cancellation between the nonlinearity caused by CSR and the initial nonlinearity. So under these circumstances authors can expect CSR to improve the beam quality. This paper provides a brief information about CSR and a full estimation of effects of CSR on beam qualities

  12. Nonlinear beam dynamics in a funnel for combining two intense ion beams

    International Nuclear Information System (INIS)

    Whealton, J.H.; Raridon, R.J.; Rothe, K.E.; Becraft, W.R.; Owens, T.L.

    1989-01-01

    The concept of funnels was introduced over the last few years with an endeavor to increase the beam intensity by combining two beams in the following fashion: The beam is, in each case, produced by an rf accelerator and thereby composed of bunches. The beam bunches are made to occupy relatively small fractions of the longitudinal phase in these cases. The bunches form each of the two beams are made to interlace and enter and rf deflector which produced the interlacing of the beams into one beam with twice as many bunches occupying twice the phase. The funnel itself, in one embodiment called the magnetic funnel, is composed of many transport elements with strong transverse focusing produced by quadruple permanent magnetic fields. An occasional rf rebuncher is introduced to recompress the beam longitudinally so the beam occupies the appropriate small fraction of velocity space in the parallel direction. Crucial elements of the funnel are the beam dynamics in the rf rebuncher and the deflector. Beam dynamics in either case must be assessed using an analysis which is described in this paper. Several components in a magnetic funnel have been examined by dint of a full three-dimensional solution to the time-dependent Vlasov-Poisson equations with all image charges included. Specifically, the rms emittance growth of subsystems is examined in detail. 11 refs., 26 figs

  13. Calculation of Coherent Synchrotron Radiation Impedance for a Beam Moving in a Curved Trajectory

    Science.gov (United States)

    Zhou, Demin; Ohmi, Kazuhito; Oide, Katsunobu; Zang, Lei; Stupakov, Gennady

    2012-01-01

    Coherent synchrotron radiation (CSR) fields are generated when a bunched beam moves along a curved trajectory. A new code, named CSRZ, was developed using finite difference method to calculate the longitudinal CSR impedance for a beam moving along a curved chamber. The method adopted in the code was originated by Agoh and Yokoya [Phys. Rev. ST Accel. Beams 7 (2004) 054403]. It solves the parabolic equation in the frequency domain in a curvilinear coordinate system. The chamber considered has uniform rectangular cross-section along the beam trajectory. The code was used to investigate the properties of CSR impedance of a single or a series of bending magnets. The calculation results indicate that the shielding effect due to outer chamber wall can be well explained by a simple optical approximation model at high frequencies. The CSR fields reflected by the outer wall may interfere with each other along a series of bending magnets and lead to sharp narrow peaks in the CSR impedance. In a small storage ring, such interference effect can be significant and may cause microwave instability, according to a simple estimate of instability threshold.

  14. Coherent and Tunable Terahertz Radiation from Graphene Surface Plasmon Polarirons Excited by Cyclotron Electron Beam

    Science.gov (United States)

    Zhao, Tao; Gong, Sen; Hu, Min; Zhong, Renbin; Liu, Diwei; Chen, Xiaoxing; Zhang, Ping; Wang, Xinran; Zhang, Chao; Wu, Peiheng; Liu, Shenggang

    2015-01-01

    Terahertz (THz) radiation can revolutionize modern science and technology. To this date, it remains big challenges to develop intense, coherent and tunable THz radiation sources that can cover the whole THz frequency region either by means of only electronics (both vacuum electronics and semiconductor electronics) or of only photonics (lasers, for example, quantum cascade laser). Here we present a mechanism which can overcome these difficulties in THz radiation generation. Due to the natural periodicity of 2π of both the circular cylindrical graphene structure and cyclotron electron beam (CEB), the surface plasmon polaritions (SPPs) dispersion can cross the light line of dielectric, making transformation of SPPs into radiation immediately possible. The dual natural periodicity also brings significant excellences to the excitation and the transformation. The fundamental and hybrid SPPs modes can be excited and transformed into radiation. The excited SPPs propagate along the cyclotron trajectory together with the beam and gain energy from the beam continuously. The radiation density is enhanced over 300 times, up to 105 W/cm2. The radiation frequency can be widely tuned by adjusting the beam energy or chemical potential. This mechanism opens a way for developing desired THz radiation sources to cover the whole THz frequency regime. PMID:26525516

  15. Analyzing the propagation behavior of coherence and polarization degrees of a phase-locked partially coherent radial flat-topped array laser beam in underwater turbulence.

    Science.gov (United States)

    Kashani, Fatemeh Dabbagh; Yousefi, Masoud

    2016-08-10

    In this research, based on an analytical expression for cross-spectral density (CSD) matrix elements, coherence and polarization properties of phase-locked partially coherent flat-topped (PCFT) radial array laser beams propagating through weak oceanic turbulence are analyzed. Spectral degrees of coherence and polarization are analytically calculated using CSD matrix elements. Also, the effective width of spatial degree of coherence (EWSDC) is calculated numerically. The simulation is done by considering the effects of source parameters (such as radius of the array setup's circle, effective width of the spectral degree of coherence, and wavelength) and turbulent ocean factors (such as the rate of dissipation of the turbulent kinetic energy per unit mass of fluid and relative strength of temperature and salinity fluctuations, Kolmogorov micro-scale, and rate of dissipation of the mean squared temperature) in detail. Results indicate that any change in the amount of turbulence factors that increase the turbulence power reduces the EWSDC significantly and causes the reduction in the degree of polarization, and occurs at shorter propagation distances but with smaller magnitudes. In addition, being valid for all conditions, the degradation rate of the EWSDC of Gaussian array beams are more in comparison with the PCFT ones. The simulation and calculation results are shown by graphs.

  16. Multifocal spectral-domain optical coherence tomography based on Bessel beam for extended imaging depth

    Science.gov (United States)

    Yi, Luying; Sun, Liqun; Ding, Wuwen

    2017-10-01

    To advance the practical application of optical coherence tomography (OCT) in the field of biomedical imaging, the imaging depth must be extended without sacrificing resolution while maintaining sufficient sensitivity. However, there is an inherent trade-off between lateral resolution and depth of field (DOF) in OCT. To address this shortcoming, this article proposes a multifocal Bessel beam spectral-domain optical coherence tomography (MBSDOCT) capable of increasing the DOF with unchanged lateral resolution and a high signal-to-noise ratio. The proposed technique is demonstrated by simulation and experiment. A three-focal MBSDOCT with an axicon lens theoretically achieved a DOF of ˜6 mm with a lateral resolution of ˜13 μm. In imaging experiments performed on the acinar cells of orange tissue, a measured DOF of ˜4 mm was demonstrated with a sensitivity penalty of ˜18.1 dB, relative to the Gaussian beam spectral-domain OCT, with a 9-mW light source.

  17. Coherent Forward Stimulated-Brillouin Scattering of a Spatially Incoherent Laser Beam in a Plasma and Its Effect on Beam Spray

    International Nuclear Information System (INIS)

    Grech, M.; Riazuelo, G.; Pesme, D.; Weber, S.; Tikhonchuk, V. T.

    2009-01-01

    A statistical model for forward stimulated-Brillouin scattering is developed for a spatially incoherent, monochromatic, laser beam propagating in a plasma. The threshold above which the laser beam spatial incoherence cannot prevent the coherent growth of forward stimulated-Brillouin scattering is computed. It is found to be well below the threshold for self-focusing. Three-dimensional simulations confirm its existence and reveal the onset of beam spray above it. From these results, we propose a new figure of merit for the control of propagation through a plasma of a spatially incoherent laser beam

  18. Coherent-phase or random-phase acceleration of electron beams in solar flares

    Science.gov (United States)

    Aschwanden, Markus J.; Benz, Arnold O.; Montello, Maria L.

    1994-01-01

    Time structures of electron beam signatures at radio wavelengths are investigated to probe correlated versus random behavior in solar flares. In particular we address the issue whether acceleration and injection of electron beams is coherently modulated by a single source, or whether the injection is driven by a stochastic (possibly spatially fragmented) process. We analyze a total of approximately = 6000 type III bursts observed by Ikarus (Zurich) in the frequency range of 100-500 MHz, during 359 solar flares with simultaneous greater than or = 25 keV hard X-ray emission, in the years 1890-1983. In 155 flares we find a total of 260 continuous type III groups, with an average number of 13 +/- 9 bursts per group, a mean duration of D = 12 +/- 14 s, a mean period of P = 2.0 +/- 1.2 s, with the highest burst rate at a frequency of nu = 310 +/- 120 MHz. Pulse periods have been measured between 0.5 and 10 s, and can be described by an exponential distribution, i.e., N(P) varies as e (exp -P/1.0s). The period shows a frequency dependence of P(nu)=46(exp-0.6)(sub MHz)s for different flares, but is invariant during a particular flare. We measure the mean period P and its standard deviation sigma (sub p) in each type III group, and quantify the degree of periodicity (or phase-coherence) by the dimensionless parameter sigma (sub p)P. The representative sample of 260 type III burst groups shows a mean periodicity of sigma (sub p/P) = 0.37 +/- 0.12, while Monte Carlo simulations of an equivalent set of truly random time series show a distinctly different value of sigma (sub p)P = 0.93 +/- 0.26. This result indicates that the injection of electron beams is coherently modulated by a particle acceleration source which is either compact or has a global organization on a timescale of seconds, in contrast to an incoherent acceleration source, which is stochastic either in time or space. We discuss the constraints on the size of the acceleration region resulting from electron beam

  19. Self-Nulling Beam Combiner Using No External Phase Inverter

    Science.gov (United States)

    Bloemhof, Eric E.

    2010-01-01

    A self-nulling beam combiner is proposed that completely eliminates the phase inversion subsystem from the nulling interferometer, and instead uses the intrinsic phase shifts in the beam splitters. Simplifying the flight instrument in this way will be a valuable enhancement of mission reliability. The tighter tolerances on R = T (R being reflection and T being transmission coefficients) required by the self-nulling configuration actually impose no new constraints on the architecture, as two adaptive nullers must be situated between beam splitters to correct small errors in the coatings. The new feature is exploiting the natural phase shifts in beam combiners to achieve the 180 phase inversion necessary for nulling. The advantage over prior art is that an entire subsystem, the field-flipping optics, can be eliminated. For ultimate simplicity in the flight instrument, one might fabricate coatings to very high tolerances and dispense with the adaptive nullers altogether, with all their moving parts, along with the field flipper subsystem. A single adaptive nuller upstream of the beam combiner may be required to correct beam train errors (systematic noise), but in some circumstances phase chopping reduces these errors substantially, and there may be ways to further reduce the chop residuals. Though such coatings are beyond the current state of the art, the mechanical simplicity and robustness of a flight system without field flipper or adaptive nullers would perhaps justify considerable effort on coating fabrication.

  20. Coherent infrared radiation from the ALS generated via femtosecond laser modulation of the electron beam

    International Nuclear Information System (INIS)

    Byrd, J.M.; Hao, Z.; Martin, M.C.; Robin, D.S.; Sannibale, F.; Schoenlein, R.W.; Venturini, M.; Zholents, A.A.; Zolotorev, M.S.

    2004-01-01

    Interaction of an electron beam with a femtosecond laser pulse co-propagating through a wiggler at the ALS produces large modulation of the electron energies within a short ∼100 fs slice of the electron bunch. Propagating around the storage ring, this bunch develops a longitudinal density perturbation due to the dispersion of electron trajectories. The length of the perturbation evolves with a distance from the wiggler but is much shorter than the electron bunch length. This perturbation causes the electron bunch to emit short pulses of temporally and spatially coherent infrared light which are automatically synchronized to the modulating laser. The intensity and spectra of the infrared light were measured in two storage ring locations for a nominal ALS lattice and for an experimental lattice with the higher momentum compaction factor. The onset of instability stimulated by laser e-beam interaction had been discovered. The infrared signal is now routinely used as a sensitive monitor for a fine tuning of the laser beam alignment during data accumulation in the experiments with femtosecond x-ray pulses

  1. Electron beam excitation of coherent sub-terahertz radiation in periodic structures manufactured by 3D printing

    Science.gov (United States)

    Phipps, A. R.; MacLachlan, A. J.; Robertson, C. W.; Zhang, L.; Konoplev, I. V.; Cross, A. W.; Phelps, A. D. R.

    2017-07-01

    For the creation of novel coherent sub-THz sources excited by electron beams there is a requirement to manufacture intricate periodic structures to produce and radiate electromagnetic fields. The specification and the measured performance is reported of a periodic structure constructed by additive manufacturing and used successfully in an electron beam driven sub-THz radiation source. Additive manufacturing, or "3D printing", is promising to be quick and cost-effective for prototyping these periodic structures.

  2. Classical and quantum ABCD-transformations and the propagation of coherent and Gaussian beams

    International Nuclear Information System (INIS)

    Ogura, Akihiro

    2009-01-01

    We develop the mathematical properties of the ABCD-transformation from the classical and quantum mechanical points of view. First, we list the four types of generating function which generate the ABCD-transformation in classical mechanics. Second, we introduce the unitary operator of the ABCD-transformation. Next, we calculate the normal ordering of this unitary operator and derive the kernels in coordinate-momentum phase space. The kernels are comprised of the generating functions, which generate the ABCD-transformation in classical mechanics. This reveals a new correspondence between classical and quantum mechanics. As an application of these kernels, we show the propagation of coherent and Gaussian beams in the context of quantum optics which corresponds to the ABCD-transformation in matrix optics.

  3. All-fiber 7x1 signal combiner for incoherent laser beam combining

    DEFF Research Database (Denmark)

    Noordegraaf, Danny; Maack, Martin D.; Skovgaard, Peter M. W.

    2011-01-01

    We demonstrate an all-fiber 7x1 signal combiner for incoherent laser beam combining. This is a potential key component for reaching several kW of stabile laser output power. The combiner couples the output from 7 single-mode (SM) fiber lasers into a single multi-mode (MM) fiber. The input signal ...

  4. New Combined Electron-Beam Methods of Wastewater Purification

    International Nuclear Information System (INIS)

    Pikaev, A.K.; Makarov, I.E.; Ponomarev, A.V.; Kartasheva, L.I.; Podzorova, E.A.; Chulkov, V.N.; Han, B.; Kim, D.K.

    1999-01-01

    The paper is a brief review of the results obtained with the participation of the authors from the study on combined electron-beam methods for purification of some wastewaters. The data on purification of wastewaters containing dyes or hydrogen peroxide and municipal wastewater in the aerosol flow are considered

  5. Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: A proof of concept

    International Nuclear Information System (INIS)

    Rüegsegger, Michael B.; Steiner, Patrick; Kowal, Jens H.; Geiser, Dominik; Pica, Alessia; Aebersold, Daniel M.

    2014-01-01

    Purpose: External beam radiation therapy is currently considered the most common treatment modality for intraocular tumors. Localization of the tumor and efficient compensation of tumor misalignment with respect to the radiation beam are crucial. According to the state of the art procedure, localization of the target volume is indirectly performed by the invasive surgical implantation of radiopaque clips or is limited to positioning the head using stereoscopic radiographies. This work represents a proof-of-concept for direct and noninvasive tumor referencing based on anterior eye topography acquired using optical coherence tomography (OCT). Methods: A prototype of a head-mounted device has been developed for automatic monitoring of tumor position and orientation in the isocentric reference frame for LINAC based treatment of intraocular tumors. Noninvasive tumor referencing is performed with six degrees of freedom based on anterior eye topography acquired using OCT and registration of a statistical eye model. The proposed prototype was tested based on enucleated pig eyes and registration accuracy was measured by comparison of the resulting transformation with tilt and torsion angles manually induced using a custom-made test bench. Results: Validation based on 12 enucleated pig eyes revealed an overall average registration error of 0.26 ± 0.08° in 87 ± 0.7 ms for tilting and 0.52 ± 0.03° in 94 ± 1.4 ms for torsion. Furthermore, dependency of sampling density on mean registration error was quantitatively assessed. Conclusions: The tumor referencing method presented in combination with the statistical eye model introduced in the past has the potential to enable noninvasive treatment and may improve quality, efficacy, and flexibility of external beam radiotherapy of intraocular tumors

  6. Electron beam combination by RF deflectors Tolerance and requirements

    CERN Document Server

    Corsini, R

    2002-01-01

    In the framework of the new Compact Linear Collider (CLIC) Test Facility CTF3, it is planned to perform a demonstration of the bunch frequency multiplication process on which the CLIC drive beam generation scheme is based. This process relies on the combination of electron bunch trains in isochronous rings using RF deflecting cavities. Specific requirements are imposed on both the beam characteristics and the RF amplitude and phase in the deflectors. In this paper, we study and specify these requirements in the case of the Preliminary Phase of CTF3.

  7. Observation of the pulp horn by swept source optical coherence tomography and cone beam computed tomography

    Science.gov (United States)

    Iino, Yoshiko; Yoshioka, Toshihiko; Hanada, Takahiro; Ebihara, Arata; Sunakawa, Mitsuhiro; Sumi, Yasunori; Suda, Hideaki

    2015-02-01

    Cone-beam computed tomography (CBCT) is one of the most useful diagnostic techniques in dentistry but it involves ionizing radiation, while swept source optical coherence tomography (SS-OCT) has been introduced recently as a nondestructive, real-time, high resolution imaging technique using low-coherence interferometry, which involves no ionizing radiation. The purpose of this study was to evaluate the ability of SS-OCT to detect the pulp horn (PH) in comparison with that of CBCT. Ten extracted human mandibular molars were used. After horizontally removing a half of the tooth crown, the distance from the cut dentin surface to PH was measured using microfocus computed tomography (Micro CT) (SL) as the gold standard, by CBCT (CL) and by SS-OCT (OL). In the SS-OCT images, only when PH was observed beneath the overlying dentin, the distance from the cut dentin surface to PH was recorded. If the pulp was exposed, it was defined as pulp exposure (PE). The results obtained by the above three methods were statistically analyzed by Spearman's rank correlation coefficient at a significance level of p PH when the distance from the cut dentin surface to PH determined by SL was 2.33 mm or less. Strong correlations of the measured values were found between SL and CL (r=0.87), SL and OL (r=0.96), and CL and OL (r=0.86). The results showed that SS-OCT images correlated closely with CBCT images, suggesting that SS-OCT can be a useful tool for the detection of PH.

  8. Consistency of the directionality of partially coherent beams in turbulence expressed in terms of the angular spread and the far-field average intensity

    International Nuclear Information System (INIS)

    Xiao-Wen, Chen; Xiao-Ling, Ji

    2010-01-01

    Under the quadratic approximation of the Rytov's phase structure function, this paper derives the general closed-form expressions for the mean-squared width and the angular spread of partially coherent beams in turbulence. It finds that under a certain condition different types of partially coherent beams may have the same directionality as a fully coherent Gaussian beam in free space and also in atmospheric turbulence if the angular spread is chosen as the characteristic parameter of beam directionality. On the other hand, it shows that generally, the directionality of partially coherent beams expressed in terms of the angular spread is not consistent with that in terms of the normalized far-field average intensity distribution in free space, but the consistency can be achieved due to turbulence. (classical areas of phenomenology)

  9. Formation of surface nanolayers in chalcogenide crystals using coherent laser beams

    Science.gov (United States)

    Ozga, K.; Fedorchuk, A. O.; El-Naggar, A. M.; Albassam, A. A.; Kityk, V.

    2018-03-01

    We have shown a possibility to form laser modified surface nanolayers with thickness up to 60 nm in some ternary chalcogenide crystals (Ag3AsS3, Ag3SbS3, Tl3SbS3) The laser treatment was performed by two coherent laser beams split in a space. As the inducing lasers we have applied continuous wave (cw) Hesbnd Cd laser at wavelength 441 nm and doubled frequency cw Nd: YAG laser at 532 nm. The spectral energies of these lasers were higher with respect to the energy gaps of the studied crystals. The optical anisotropy was appeared and defected by monitoring of birefringence at probing wavelength of cw Hesbnd Ne laser at λ = 3390 nm. The changes of the laser stimulated near the surface layer morphology was monitored by TEM and AFM methods as well as by the reflected optical second harmonic generation at fundamental wavelength of microsecond CO2 laser generating at wavelength 10600 nm. This technique may open a new approach for the formation of the near the surface nanolayers in chalcogenides using external cw laser illumination.

  10. Experimental investigation of a coherent flute instability using a heavy ion beam probe

    International Nuclear Information System (INIS)

    Glowienka, J.C.; Jennings, W.C.; Hickok, R.L.

    1988-01-01

    A coherent, low-frequency instability found in a cylindrical, hollow cathode arc plasma has been investigated by using a heavy ion beam probe (HIBP). The energy density of the plasma was high enough to render it inaccessible to Langmuir probes, but the HIBP was able to provide measurements throughout the plasma cross section. The data clearly show that azimuthal symmetry does not exist. Radial profiles of steady-state density and space potential and of simultaneous n, phi amplitude and phase were obtained to allow detailed comparison between theory and experiment. Predictions from a cylindrically symmetric, small-perturbation theoretical model provide reasonably conclusive identification of the instability as a Kelvin--Helmholtz flute driven by and localized in a region of fluid shear. The most serious discrepancy was with regard to the oscillation frequency, which was consistently predicted to be three to four times lower than that observed experimentally. The reason for the discrepancy is not understood, but it is probably related to inadequacies in the theory caused by assumptions of azimuthal symmetry and of small linear perturbations

  11. A large-area perfect crystal neutron interferometer optimized for coherent beam-deflection experiments: Preparation and performance

    International Nuclear Information System (INIS)

    Zawisky, M.; Springer, J.; Farthofer, R.; Kuetgens, U.

    2010-01-01

    The fabrication and benefits of the actually largest perfect crystal interferometer are presented. New features are longer beam paths, precise symmetric lattice orientation and the use of several higher order reflections. The optimized design offers ample space for beam manipulators, in particular the use of different prism arrangements for coherent beam-deflection experiments. The interferometer can be utilized in one- or two-loop configuration at different wavelengths (2.7, 1.36, 0.9 and 0.7 A) by selecting (2 2 0) or higher order reflections (4 4 0), (6 6 0) and (8 8 0), without changing the beam geometry. The interferometer was tested successfully at ILL instrument S18 where 73% visibility of interference fringes have been reached in (4 4 0) reflection. This indicates that larger interferometers of this type are feasible in future.

  12. Trigger and DAQ in the Combined Test Beam

    CERN Multimedia

    Dobson, M; Padilla, C

    2004-01-01

    Introduction During the Combined Test Beam the latest prototype of the ATLAS Trigger and DAQ system is being used to support the data taking of all the detectors. Further development of the TDAQ subsystems benefits from the direct experience given by the integration in the beam test. Support of detectors for the Combined Test Beam All ATLAS detectors need their own detector-specific DAQ development. The readout electronics is controlled by a Readout Driver (ROD), custom-built for each detector. The ROD receives data for events that are accepted by the first level trigger. The detector-specific part of the DAQ system needs to control the ROD and to respond to commands of the central DAQ (e.g. to "Start" a run). The ROD module then sends event data to a Readout System (ROS), a PC with special receiver modules/buffers. At this point the data enters the realm of the ATLAS DAQ and High Level Trigger system, constructed from Linux PCs connected with gigabit Ethernet networks. Most ATLAS detectors, representing s...

  13. Experimental results on electron beam combination and bunch frequency multiplication

    Directory of Open Access Journals (Sweden)

    Roberto Corsini

    2004-04-01

    Full Text Available The aim of the CLIC Test Facility CTF3 at CERN is to demonstrate the feasibility of the key points of the two-beam acceleration based compact linear collider study. In particular, it addresses the efficient generation of a drive beam with the appropriate time structure of the electron bunches in order to produce high power rf pulses at a frequency of 30 GHz. This time structure requires a high bunch repetition frequency. It is obtained by successive injections of bunch trains into an isochronous ring using transversely deflecting rf structures. The major goal of the now completed first phase of the CTF3 was to achieve the bunch train combination at low charge. In this paper, we give a description of the project and summarize the experimental results, with a focus on the successful bunch frequency multiplication for various factors up to 5.

  14. Coherent instabilities of proton beams in accelerators and storage rings - experimental results, diagnosis and cures

    International Nuclear Information System (INIS)

    Schnell, W.

    1977-01-01

    The author discusses diagnosis and cure of proton beam instabilities in accelerators and storage rings. Coasting beams and bunched beams are treated separately and both transverse and longitudinal instabilities are considered. (B.D.)

  15. Combined electron beam and UV lithography in SU-8

    DEFF Research Database (Denmark)

    Gersborg-Hansen, Morten; Thamdrup, Lasse Højlund; Mironov, Andrej

    2007-01-01

    We present combined electron beam and UV lithography (CEUL) in SU-8 as a fast and flexible lithographic technique for prototyping of functional polymer devices and pattern transfer applications. CEUL is a lithographic technique suitable for defining both micrometer and nanometer scale features...... in a single polymer film on the wafer scale. The height of the micrometer and nanometer scale features is matched within 30 nm. As a pattern transfer application, we demonstrate stamp fabrication and thermal nanoimprint of a 2-dimensional array of 100 nm wide lines with a pitch of 380 nm in connection...

  16. High-energy coherent terahertz radiation emitted by wide-angle electron beams from a laser-wakefield accelerator

    Science.gov (United States)

    Yang, Xue; Brunetti, Enrico; Jaroszynski, Dino A.

    2018-04-01

    High-charge electron beams produced by laser-wakefield accelerators are potentially novel, scalable sources of high-power terahertz radiation suitable for applications requiring high-intensity fields. When an intense laser pulse propagates in underdense plasma, it can generate femtosecond duration, self-injected picocoulomb electron bunches that accelerate on-axis to energies from 10s of MeV to several GeV, depending on laser intensity and plasma density. The process leading to the formation of the accelerating structure also generates non-injected, sub-picosecond duration, 1–2 MeV nanocoulomb electron beams emitted obliquely into a hollow cone around the laser propagation axis. These wide-angle beams are stable and depend weakly on laser and plasma parameters. Here we perform simulations to characterise the coherent transition radiation emitted by these beams if passed through a thin metal foil, or directly at the plasma–vacuum interface, showing that coherent terahertz radiation with 10s μJ to mJ-level energy can be produced with an optical to terahertz conversion efficiency up to 10‑4–10‑3.

  17. Ultrafast transmission electron microscopy using a laser-driven field emitter: Femtosecond resolution with a high coherence electron beam.

    Science.gov (United States)

    Feist, Armin; Bach, Nora; Rubiano da Silva, Nara; Danz, Thomas; Möller, Marcel; Priebe, Katharina E; Domröse, Till; Gatzmann, J Gregor; Rost, Stefan; Schauss, Jakob; Strauch, Stefanie; Bormann, Reiner; Sivis, Murat; Schäfer, Sascha; Ropers, Claus

    2017-05-01

    We present the development of the first ultrafast transmission electron microscope (UTEM) driven by localized photoemission from a field emitter cathode. We describe the implementation of the instrument, the photoemitter concept and the quantitative electron beam parameters achieved. Establishing a new source for ultrafast TEM, the Göttingen UTEM employs nano-localized linear photoemission from a Schottky emitter, which enables operation with freely tunable temporal structure, from continuous wave to femtosecond pulsed mode. Using this emission mechanism, we achieve record pulse properties in ultrafast electron microscopy of 9Å focused beam diameter, 200fs pulse duration and 0.6eV energy width. We illustrate the possibility to conduct ultrafast imaging, diffraction, holography and spectroscopy with this instrument and also discuss opportunities to harness quantum coherent interactions between intense laser fields and free-electron beams. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  18. Nonlinear Response of Cantilever Beams to Combination and Subcombination Resonances

    Directory of Open Access Journals (Sweden)

    Ali H. Nayfeh

    1998-01-01

    Full Text Available The nonlinear planar response of cantilever metallic beams to combination parametric and external subcombination resonances is investigated, taking into account the effects of cubic geometric and inertia nonlinearities. The beams considered here are assumed to have large length-to-width aspect ratios and thin rectangular cross sections. Hence, the effects of shear deformations and rotatory inertia are neglected. For the case of combination parametric resonance, a two-mode Galerkin discretization along with Hamilton’s extended principle is used to obtain two second-order nonlinear ordinary-differential equations of motion and associated boundary conditions. Then, the method of multiple scales is applied to obtain a set of four first-order nonlinear ordinary-differential equations governing the modulation of the amplitudes and phases of the two excited modes. For the case of subcombination resonance, the method of multiple scales is applied directly to the Lagrangian and virtual-work term. Then using Hamilton’s extended principle, we obtain a set of four first-order nonlinear ordinary-differential equations governing the amplitudes and phases of the two excited modes. In both cases, the modulation equations are used to generate frequency- and force-response curves. We found that the trivial solution exhibits a jump as it undergoes a subcritical pitchfork bifurcation. Similarly, the nontrivial solutions also exhibit jumps as they undergo saddle-node bifurcations.

  19. Acousto-optical tunable filter for combined wideband, spectral, and optical coherence microscopy.

    Science.gov (United States)

    Machikhin, Alexander S; Pozhar, Vitold E; Viskovatykh, Alexander V; Burmak, Ludmila I

    2015-09-01

    A multimodal technique for inspection of microscopic objects by means of wideband optical microscopy, spectral microscopy, and optical coherence microscopy is described, implemented, and tested. The key feature is the spectral selection of light in the output arm of an interferometer with use of the specialized imaging acousto-optical tunable filter. In this filter, two interfering optical beams are diffracted via the same ultrasound wave without destruction of interference image structure. The basic requirements for the acousto-optical tunable filter are defined, and mathematical formulas for calculation of its parameters are derived. Theoretical estimation of the achievable accuracy of the 3D image reconstruction is presented and experimental proofs are given. It is demonstrated that spectral imaging can also be accompanied by measurement of the quantitative reflectance spectra. Examples of inspection of optically transparent and nontransparent samples demonstrate the applicability of the technique.

  20. Ultrafast transmission electron microscopy using a laser-driven field emitter: Femtosecond resolution with a high coherence electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Feist, Armin; Bach, Nora; Rubiano da Silva, Nara; Danz, Thomas; Möller, Marcel; Priebe, Katharina E.; Domröse, Till; Gatzmann, J. Gregor; Rost, Stefan; Schauss, Jakob; Strauch, Stefanie; Bormann, Reiner; Sivis, Murat; Schäfer, Sascha, E-mail: sascha.schaefer@phys.uni-goettingen.de; Ropers, Claus, E-mail: claus.ropers@uni-goettingen.de

    2017-05-15

    We present the development of the first ultrafast transmission electron microscope (UTEM) driven by localized photoemission from a field emitter cathode. We describe the implementation of the instrument, the photoemitter concept and the quantitative electron beam parameters achieved. Establishing a new source for ultrafast TEM, the Göttingen UTEM employs nano-localized linear photoemission from a Schottky emitter, which enables operation with freely tunable temporal structure, from continuous wave to femtosecond pulsed mode. Using this emission mechanism, we achieve record pulse properties in ultrafast electron microscopy of 9 Å focused beam diameter, 200 fs pulse duration and 0.6 eV energy width. We illustrate the possibility to conduct ultrafast imaging, diffraction, holography and spectroscopy with this instrument and also discuss opportunities to harness quantum coherent interactions between intense laser fields and free-electron beams. - Highlights: • First implementation of an ultrafast TEM employing a nanoscale photocathode. • Localized single photon-photoemission from nanoscopic field emitter yields low emittance ultrashort electron pulses. • Electron pulses focused down to ~9 Å, with a duration of 200 fs and an energy width of 0.6 eV are demonstrated. • Quantitative characterization of ultrafast electron gun emittance and brightness. • A range of applications of high coherence ultrashort electron pulses is shown.

  1. Combined performance studies for electrons at the 2004 ATLAS combined test-beam

    Science.gov (United States)

    Abat, E.; Abdallah, J. M.; Addy, T. N.; Adragna, P.; Aharrouche, M.; Ahmad, A.; Akesson, T. P. A.; Aleksa, M.; Alexa, C.; Anderson, K.; Andreazza, A.; Anghinolfi, F.; Antonaki, A.; Arabidze, G.; Arik, E.; Atkinson, T.; Baines, J.; Baker, O. K.; Banfi, D.; Baron, S.; Barr, A. J.; Beccherle, R.; Beck, H. P.; Belhorma, B.; Bell, P. J.; Benchekroun, D.; Benjamin, D. P.; Benslama, K.; Bergeaas Kuutmann, E.; Bernabeu, J.; Bertelsen, H.; Binet, S.; Biscarat, C.; Boldea, V.; Bondarenko, V. G.; Boonekamp, M.; Bosman, M.; Bourdarios, C.; Broklova, Z.; Burckhart Chromek, D.; Bychkov, V.; Callahan, J.; Calvet, D.; Canneri, M.; Capeáns Garrido, M.; Caprini, M.; Cardiel Sas, L.; Carli, T.; Carminati, L.; Carvalho, J.; Cascella, M.; Castillo, M. V.; Catinaccio, A.; Cauz, D.; Cavalli, D.; Cavalli Sforza, M.; Cavasinni, V.; Cetin, S. A.; Chen, H.; Cherkaoui, R.; Chevalier, L.; Chevallier, F.; Chouridou, S.; Ciobotaru, M.; Citterio, M.; Clark, A.; Cleland, B.; Cobal, M.; Cogneras, E.; Conde Muino, P.; Consonni, M.; Constantinescu, S.; Cornelissen, T.; Correard, S.; Corso Radu, A.; Costa, G.; Costa, M. J.; Costanzo, D.; Cuneo, S.; Cwetanski, P.; Da Silva, D.; Dam, M.; Dameri, M.; Danielsson, H. O.; Dannheim, D.; Darbo, G.; Davidek, T.; De, K.; Defay, P. O.; Dekhissi, B.; Del Peso, J.; Del Prete, T.; Delmastro, M.; Derue, F.; Di Ciaccio, L.; Di Girolamo, B.; Dita, S.; Dittus, F.; Djama, F.; Djobava, T.; Dobos, D.; Dobson, M.; Dolgoshein, B. A.; Dotti, A.; Drake, G.; Drasal, Z.; Dressnandt, N.; Driouchi, C.; Drohan, J.; Ebenstein, W. L.; Eerola, P.; Efthymiopoulos, I.; Egorov, K.; Eifert, T. F.; Einsweiler, K.; El Kacimi, M.; Elsing, M.; Emelyanov, D.; Escobar, C.; Etienvre, A. I.; Fabich, A.; Facius, K.; Fakhr-Edine, A. I.; Fanti, M.; Farbin, A.; Farthouat, P.; Fassouliotis, D.; Fayard, L.; Febbraro, R.; Fedin, O. L.; Fenyuk, A.; Fergusson, D.; Ferrari, P.; Ferrari, R.; Ferreira, B. C.; Ferrer, A.; Ferrere, D.; Filippini, G.; Flick, T.; Fournier, D.; Francavilla, P.; Francis, D.; Froeschl, R.; Froidevaux, D.; Fullana, E.; Gadomski, S.; Gagliardi, G.; Gagnon, P.; Gallas, M.; Gallop, B. J.; Gameiro, S.; Gan, K. K.; Garcia, R.; Garcia, C.; Gavrilenko, I. L.; Gemme, C.; Gerlach, P.; Ghodbane, N.; Giakoumopoulou, V.; Giangiobbe, V.; Giokaris, N.; Glonti, G.; Goettfert, T.; Golling, T.; Gollub, N.; Gomes, A.; Gomez, M. D.; Gonzalez-Sevilla, S.; Goodrick, M. J.; Gorfine, G.; Gorini, B.; Goujdami, D.; Grahn, K.-J.; Grenier, P.; Grigalashvili, N.; Grishkevich, Y.; Grosse-Knetter, J.; Gruwe, M.; Guicheney, C.; Gupta, A.; Haeberli, C.; Haertel, R.; Hajduk, Z.; Hakobyan, H.; Hance, M.; Hansen, J. D.; Hansen, P. H.; Hara, K.; Harvey, A., Jr.; Hawkings, R. J.; Heinemann, F. E. W.; Henriques Correia, A.; Henss, T.; Hervas, L.; Higon, E.; Hill, J. C.; Hoffman, J.; Hostachy, J. Y.; Hruska, I.; Hubaut, F.; Huegging, F.; Hulsbergen, W.; Hurwitz, M.; Iconomidou-Fayard, L.; Jansen, E.; Jen-La Plante, I.; Johansson, P. D. C.; Jon-And, K.; Joos, M.; Jorgensen, S.; Joseph, J.; Kaczmarska, A.; Kado, M.; Karyukhin, A.; Kataoka, M.; Kayumov, F.; Kazarov, A.; Keener, P. T.; Kekelidze, G. D.; Kerschen, N.; Kersten, S.; Khomich, A.; Khoriauli, G.; Khramov, E.; Khristachev, A.; Khubua, J.; Kittelmann, T. H.; Klingenberg, R.; Klinkby, E. B.; Kodys, P.; Koffas, T.; Kolos, S.; Konovalov, S. P.; Konstantinidis, N.; Kopikov, S.; Korolkov, I.; Kostyukhin, V.; Kovalenko, S.; Kowalski, T. Z.; Krüger, K.; Kramarenko, V.; Kudin, L. G.; Kulchitsky, Y.; Lacasta, C.; Lafaye, R.; Laforge, B.; Lampl, W.; Lanni, F.; Laplace, S.; Lari, T.; Le Bihan, A.-C.; Lechowski, M.; Ledroit-Guillon, F.; Lehmann, G.; Leitner, R.; Lelas, D.; Lester, C. G.; Liang, Z.; Lichard, P.; Liebig, W.; Lipniacka, A.; Lokajicek, M.; Louchard, L.; Lourerio, K. F.; Lucotte, A.; Luehring, F.; Lund-Jensen, B.; Lundberg, B.; Ma, H.; Mackeprang, R.; Maio, A.; Maleev, V. P.; Malek, F.; Mandelli, L.; Maneira, J.; Mangin-Brinet, M.; Manousakis, A.; Mapelli, L.; Marques, C.; Garcia, S. Marti i.; Martin, F.; Mathes, M.; Mazzanti, M.; McFarlane, K. W.; McPherson, R.; Mchedlidze, G.; Mehlhase, S.; Meirosu, C.; Meng, Z.; Meroni, C.; Mialkovski, V.; Mikulec, B.; Milstead, D.; Minashvili, I.; Mindur, B.; Mitsou, V. A.; Moed, S.; Monnier, E.; Moorhead, G.; Morettini, P.; Morozov, S. V.; Mosidze, M.; Mouraviev, S. V.; Moyse, E. W. J.; Munar, A.; Myagkov, A.; Nadtochi, A. V.; Nakamura, K.; Nechaeva, P.; Negri, A.; Nemecek, S.; Nessi, M.; Nesterov, S. Y.; Newcomer, F. M.; Nikitine, I.; Nikolaev, K.; Nikolic-Audit, I.; Ogren, H.; Oh, S. H.; Oleshko, S. B.; Olszowska, J.; Onofre, A.; Padilla Aranda, C.; Paganis, S.; Pallin, D.; Pantea, D.; Paolone, V.; Parodi, F.; Parsons, J.; Parzhitskiy, S.; Pasqualucci, E.; Passmored, S. M.; Pater, J.; Patrichev, S.; Peez, M.; Perez Reale, V.; Perini, L.; Peshekhonov, V. D.; Petersen, J.; Petersen, T. C.; Petti, R.; Phillips, P. W.; Pina, J.; Pinto, B.; Podlyski, F.; Poggioli, L.; Poppleton, A.; Poveda, J.; Pralavorio, P.; Pribyl, L.; Price, M. J.; Prieur, D.; Puigdengoles, C.; Puzo, P.; RØhne, O.; Ragusa, F.; Rajagopalan, S.; Reeves, K.; Reisinger, I.; Rembser, C.; Bruckman de Renstrom, P. A.; Reznicek, P.; Ridel, M.; Risso, P.; Riu, I.; Robinson, D.; Roda, C.; Roe, S.; Rohne, O.; Romaniouk, A.; Rousseau, D.; Rozanov, A.; Ruiz, A.; Rusakovich, N.; Rust, D.; Ryabov, Y. F.; Ryjov, V.; Salto, O.; Salvachua, B.; Salzburger, A.; Sandaker, H.; Santamarina Rios, C.; Santi, L.; Santoni, C.; Saraiva, J. G.; Sarri, F.; Sauvage, G.; Says, L. P.; Schaefer, M.; Schegelsky, V. A.; Schiavi, C.; Schieck, J.; Schlager, G.; Schlereth, J.; Schmitt, C.; Schultes, J.; Schwemling, P.; Schwindling, J.; Seixas, J. M.; Seliverstov, D. M.; Serin, L.; Sfyrla, A.; Shalanda, N.; Shaw, C.; Shin, T.; Shmeleva, A.; Silva, J.; Simion, S.; Simonyan, M.; Sloper, J. E.; Smirnov, S. Yu; Smirnova, L.; Solans, C.; Solodkov, A.; Solovianov, O.; Soloviev, I.; Sosnovtsev, V. V.; Spanò, F.; Speckmayer, P.; Stancu, S.; Stanek, R.; Starchenko, E.; Straessner, A.; Suchkov, S. I.; Suk, M.; Szczygiel, R.; Tarrade, F.; Tartarelli, F.; Tas, P.; Tayalati, Y.; Tegenfeldt, F.; Teuscher, R.; Thioye, M.; Tikhomirov, V. O.; Timmermans, C. J. W. P.; Tisserant, S.; Toczek, B.; Tremblet, L.; Troncon, C.; Tsiareshka, P.; Tyndel, M.; Karagoez Unel, M.; Unal, G.; Unel, G.; Usai, G.; Van Berg, R.; Valero, A.; Valkar, S.; Valls, J. A.; Vandelli, W.; Vannucci, F.; Vartapetian, A.; Vassilakopoulos, V. I.; Vasilyeva, L.; Vazeille, F.; Vernocchi, F.; Vetter-Cole, Y.; Vichou, I.; Vinogradov, V.; Virzi, J.; Vivarelli, I.; de Vivie, J. B.; Volpi, M.; Anh, T. Vu; Wang, C.; Warren, M.; Weber, J.; Weber, M.; Weidberg, A. R.; Weingarten, J.; Wells, P. S.; Werner, P.; Wheeler, S.; Wiessmann, M.; Wilkens, H.; Williams, H. H.; Wingerter-Seez, I.; Yasu, Y.; Zaitsev, A.; Zenin, A.; Zenis, T.; Zenonos, Z.; Zhang, H.; Zhelezko, A.; Zhou, N.

    2010-11-01

    In 2004 at the ATLAS (A Toroidal LHC ApparatuS) combined test beam, one slice of the ATLAS barrel detector (including an Inner Detector set-up and the Liquid Argon calorimeter) was exposed to particles from the H8 SPS beam line at CERN. It was the first occasion to test the combined electron performance of ATLAS. This paper presents results obtained for the momentum measurement p with the Inner Detector and for the performance of the electron measurement with the LAr calorimeter (energy E linearity and resolution) in the presence of a magnetic field in the Inner Detector for momenta ranging from 20 GeV/c to 100 GeV/c. Furthermore the particle identification capabilities of the Transition Radiation Tracker, Bremsstrahlungs-recovery algorithms relying on the LAr calorimeter and results obtained for the E/p ratio and a way how to extract scale parameters will be discussed.

  2. Dual-beam optical coherence tomography system for quantification of flow velocity in capillary phantoms

    Science.gov (United States)

    Daly, S. M.; Silien, C.; Leahy, M. J.

    2012-03-01

    The quantification of (blood) flow velocity within the vasculature has potent diagnostic and prognostic potential. Assessment of flow irregularities in the form of increased permeability (micro haemorrhaging), the presence of avascular areas, or conversely the presence of vessels with enlarged or increased tortuosity in the acral regions of the body may provide a means of non-invasive in vivo assessment. If assessment of dermal flow dynamics were performed in a routine manner, the existence and prevalence of ailments such as diabetes mellitus, psoriatic arthritis and Raynaud's condition may be confirmed prior to clinical suspicion. This may prove advantageous in cases wherein the efficacy of a prescribed treatment is dictated by a prompt diagnosis and to alleviate patient discomfort through early detection. Optical Coherence Tomography (OCT) is an imaging modality which utilises the principle of optical interferometry to distinguish between spatial changes in refractive index within the vasculature and thus formulate a multi-dimensional representation of the structure of the epi- and dermal skin layers. The use of the Doppler functionality has been the predominant force for the quantification of moving particles within media, elucidated via estimation of the phase shift in OCT A-scans. However, the theoretical formulation for the assessment of these phase shifts dictates that the angle between the incident light source and the vessel under question be known a priori; this may be achieved via excisional biopsy of the tissue segment in question, but is counter to the non-invasive premise of the OCT technique. To address the issue of angular dependence, an alternate means of estimating absolute flow velocity is presented. The design and development of a dual-beam (db) system incorporating an optical switch mechanism for signal discrimination of two spatially disparate points enabling quasi-simultaneous multiple specimen scanning is described. A crosscorrelation (c

  3. Improving external beam radiotherapy by combination with internal irradiation.

    Science.gov (United States)

    Dietrich, A; Koi, L; Zöphel, K; Sihver, W; Kotzerke, J; Baumann, M; Krause, M

    2015-07-01

    The efficacy of external beam radiotherapy (EBRT) is dose dependent, but the dose that can be applied to solid tumour lesions is limited by the sensitivity of the surrounding tissue. The combination of EBRT with systemically applied radioimmunotherapy (RIT) is a promising approach to increase efficacy of radiotherapy. Toxicities of both treatment modalities of this combination of internal and external radiotherapy (CIERT) are not additive, as different organs at risk are in target. However, advantages of both single treatments are combined, for example, precise high dose delivery to the bulk tumour via standard EBRT, which can be increased by addition of RIT, and potential targeting of micrometastases by RIT. Eventually, theragnostic radionuclide pairs can be used to predict uptake of the radiotherapeutic drug prior to and during therapy and find individual patients who may benefit from this treatment. This review aims to highlight the outcome of pre-clinical studies on CIERT and resultant questions for translation into the clinic. Few clinical data are available until now and reasons as well as challenges for clinical implementation are discussed.

  4. Preliminary Demonstration of Power Beaming With Non-Coherent Laser Diode Arrays

    National Research Council Canada - National Science Library

    Kare, Jordin

    1999-01-01

    A preliminary demonstration of free-space electric power transmission has been conducted using non-coherent laser diode arrays as the transmitter and standard silicon photovoltaic cell arrays as the receiver...

  5. Two-beam ultrabroadband coherent anti-Stokes Raman spectroscopy for high resolution gas-phase multiplex imaging

    International Nuclear Information System (INIS)

    Bohlin, Alexis; Kliewer, Christopher J.

    2014-01-01

    We propose and develop a method for wideband coherent anti-Stokes Raman spectroscopy (CARS) in the gas phase and demonstrate the single-shot measurement of N 2 , H 2 , CO 2 , O 2 , and CH 4 . Pure-rotational and vibrational O-, Q-, and S- branch spectra are collected simultaneously, with high spectral and spatial resolution, and within a single-laser-shot. The relative intensity of the rotational and vibrational signals can be tuned arbitrarily using polarization techniques. The ultrashort 7 fs pump and Stokes pulses are automatically overlapped temporally and spatially using a two-beam CARS technique, and the crossed probe beam allows for excellent spatial sectioning of the probed location

  6. Improving the efficiency of optical coherence tomography by using the non-ideal behaviour of a polarising beam splitter

    KAUST Repository

    Lippok, Norman

    2011-03-30

    We present a new way of improving the efficiency of optical coherence tomography by using the polarisation crosstalk of a polarizing beam splitter to direct most of the available source optical power to the sample. The use of a quarter wave plate in both the reference and the sample arms allows most of the sample power to be directed to the detector while adjusting the reference arm to ensure noise optimised operation. As a result, the sensitivity of such a system can be improved by 6 dB, or alternatively the acquisition time can be improved by a factor of 4 for shot noise limited performance,compared to a traditional OCT configuration using a 50/50 beam splitter. © 2011 Optical Society of America.

  7. Scintillation of partially coherent Gaussian—Schell model beam propagation in slant atmospheric turbulence considering inner- and outer-scale effects

    International Nuclear Information System (INIS)

    Li Ya-Qing; Wu Zhen-Sen; Zhang Yuan-Yuan; Wang Ming-Jun

    2014-01-01

    Based on the modified Rytov theory and the international telecommunication union-radio (ITU-R) slant atmospheric structure constant model, the uniform scintillation index of partially coherent Gaussian—Schell model (GSM) beam propagation in the slant path is derived from weak- to strong-turbulence regions considering inner- and outer-scale effects. The effects of wavelength of beams and inner- and outer-scale of turbulence on scintillation are analyzed numerically. Comparison between the scintillation of GSM beams under the von Karman spectrum and that of beams under the modified Hill spectrum is made. The results obtained show that the scintillation index obtained under the von Karman spectrum is smaller than that under the modified Hill spectrum. This study can find theory bases for the experiments of the partially coherent GSM beam propagation through atmospheric turbulence. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  8. Combined image-processing algorithms for improved optical coherence tomography of prostate nerves

    Science.gov (United States)

    Chitchian, Shahab; Weldon, Thomas P.; Fiddy, Michael A.; Fried, Nathaniel M.

    2010-07-01

    Cavernous nerves course along the surface of the prostate gland and are responsible for erectile function. These nerves are at risk of injury during surgical removal of a cancerous prostate gland. In this work, a combination of segmentation, denoising, and edge detection algorithms are applied to time-domain optical coherence tomography (OCT) images of rat prostate to improve identification of cavernous nerves. First, OCT images of the prostate are segmented to differentiate the cavernous nerves from the prostate gland. Then, a locally adaptive denoising algorithm using a dual-tree complex wavelet transform is applied to reduce speckle noise. Finally, edge detection is used to provide deeper imaging of the prostate gland. Combined application of these three algorithms results in improved signal-to-noise ratio, imaging depth, and automatic identification of the cavernous nerves, which may be of direct benefit for use in laparoscopic and robotic nerve-sparing prostate cancer surgery.

  9. Development of a coherent THz radiation source based on the ultra-short electron beam and its applications

    International Nuclear Information System (INIS)

    Kuroda, R.; Yasumoto, M.; Toyokawa, H.; Sei, N.; Koike, M.; Yamada, K.

    2011-01-01

    At the National Institute of Advanced Industrial Science and Technology (AIST), a coherent terahertz (THz) radiation source has been developed based on an ultra-short electron beam using an S-band compact electron linac. The designed THz pulse has a high peak power of more than 1 kW in the frequency range 0.1-2 THz. The entire system is located in one research room of about 10 m square. The linac consists of a laser photocathode rf gun (BNL type) with a Cs 2 Te photocathode load-lock system and two 1.5-m-long S-band accelerator tubes. The electron beam can be accelerated up to approximately 42 MeV. The electron bunch was compressed to less than 1 ps (rms) with a magnetic bunch compressor. The coherent synchrotron radiation (CSR) of the THz region was generated from the ultra-short electron bunch at the 90 o bending magnet, and it was extracted from a z-cut quartz window for THz applications. In this work, the THz scanning transmission imaging was successfully demonstrated for measuring the freshness of a vegetable leaf over a period of time.

  10. Corkscrew Motion of an Electron Beam due to Coherent Variations in Accelerating Potentials

    Energy Technology Data Exchange (ETDEWEB)

    Ekdahl, Carl August [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-13

    Corkscrew motion results from the interaction of fluctuations of beam electron energy with accidental magnetic dipoles caused by misalignment of the beam transport solenoids. Corkscrew is a serious concern for high-current linear induction accelerators (LIA). A simple scaling law for corkscrew amplitude derived from a theory based on a constant-energy beam coasting through a uniform magnetic field has often been used to assess LIA vulnerability to this effect. We use a beam dynamics code to verify that this scaling also holds for an accelerated beam in a non-uniform magnetic field, as in a real accelerator. Results of simulations with this code are strikingly similar to measurements on one of the LIAs at Los Alamos National Laboratory.

  11. Combined external beam and intraluminal radiotherapy for irresectable Klatskin tumors

    Energy Technology Data Exchange (ETDEWEB)

    Schleicher, U.M. [Klinik fuer Strahlentherapie, Technische Hochschule Aachen (Germany); Staatz, G. [Klinik fuer Radiologische Diagnostik, Technische Hochschule Aachen (Germany); Alzen, G. [Klinik fuer Radiologische Diagnostik, Technische Hochschule Aachen (Germany); Abt. Kinderradiologie, Giessen Univ. (Germany); Andreopoulos, D. [Klinik fuer Strahlentherapie, Technische Hochschule Aachen (Germany); BOC Oncology Centre, Nikosia (Cyprus)

    2002-12-01

    Background: In most cases of proximal cholangiocarcinoma, curative surgery is not possible. Radiotherapy can be used for palliative treatment. We report our experience with combined external beam and intraluminal radiotherapy of advanced Klatskin's tumors. Patients and Methods: 30 patients were treated for extrahepatic proximal bile duct cancer. Our schedule consisted for external beam radiotherapy (median dose 30 Gy) and a high-dose-rate brachytherapy boost (median dose 40 Gy) delivered in four or five fractions, which could be applied completely in twelve of our patients. 15 patients in the brachytherapy and nine patients in the non-brachytherapy group received additional low-dose chemotherapy with 5-fluorouracil. Results: The brachytherapy boost dose improved the effect of external beam radiotherapy by increasing survival from a median of 3.9 months in the non-brachytherapy group to 9.1 months in the brachytherapy group. The effect was obvious in patients receiving a brachytherapy dose above 30 Gy, and in those without jaundice at the beginning of radiotherapy (p<0.05). Conclusions: The poor prognosis in patients with advanced Klatskin's tumors may be improved by combination therapy, with the role of brachytherapy and chemotherapy still to be defined. Our results suggest that patients without jaundice should be offered brachytherapy, and that a full dose of more than 30 Gy should be applied. (orig.) [German] Hintergrund: Bei den meisten Patienten mit proximalen Cholangiokarzinomen ist eine kurative Operation nicht mehr moeglich. Im Rahmen der Palliativbehandlung kann die Strahlentherapie eingesetzt werden. Wir berichten ueber unsere Erfahrungen mit der Kombination aus perkutaner und intraluminaler Strahlentherapie fortgeschrittener Klatskin-Tumoren. Patienten und Methode: 30 Patienten wurden wegen extrahepatischer proximaler Gallengangskarzinome behandelt. Unser Therapieschema umfasste eine perkutane Strahlentherapie (mediane Dosis: 30 Gy) sowie einen

  12. Investigation of fish otoliths by combined ion beam analysis

    International Nuclear Information System (INIS)

    Huszank, R.; Simon, A.; Keresztessy, K.

    2008-01-01

    Complete text of publication follows. This work was implemented within the framework of the Hungarian Ion beam Physics Platform (http://hipp.atomki.hu/). Otoliths are small structures, 'the ear stones' of a fish, and are used to detect acceleration and orientation. They are composed of a combination of protein matrix and calcium carbonate (CaCO 3 ) forming aragonite micro crystals. They have an annually deposited layered conformation with a microstructure corresponding to the seasonal and daily increments. Trace elements, such as Sr, Zn, Fe etc., are also incorporated into the otolith from the environment and the nutrition. The elemental distribution of the otolith of fresh water fish burbot (Lota lota L.) collected in Hungary was measured with Elastic Recoil Detection Analysis (ERDA), Rutherford backscattering spectrometry (RBS) and Particle Induced X-ray Emission (PIXE) at the Nuclear Microprobe Facility of HAS ATOMKI. The spatial 3D structure of the otolith could be observed with a sub-micrometer resolution. It is confirmed that the aragonite micro-crystals are covered by an organic layer and there are some protein rich regions in the otolith, too. By applying the RBSMAST code developed for RBS on macroscopic structure, it was proven that the orientation of the needle shaped aragonite crystals is considerably different at adjacent locations in the otolith. The organic and inorganic component of the otolith could be set apart in the depth selective hydrogen and calcium maps derived by micro- ERDA and micro-RBS. Similar structural analysis could be done near the surface by combining the C, O and Ca elemental maps determined by micro-PIXE measurements. It was observed that the trace metal Zn is bound to the protein component. Acknowledgements This work was partially supported by the Hungarian OTKA Grant No. T046238 and the EU cofunded Economic Competitiveness Operative Programme (GVOP-3.2.1.-2004-04-0402/3.0)

  13. Multispectral scanning laser ophthalmoscopy combined with optical coherence tomography for simultaneous in vivo mouse retinal imaging

    Science.gov (United States)

    Zhang, Pengfei; Zam, Azhar; Jian, Yifan; Wang, Xinlei; Burns, Marie E.; Sarunic, Marinko V.; Pugh, Edward N.; Zawadzki, Robert J.

    2015-03-01

    A compact, non-invasive multi-modal system has been developed for in vivo mouse retina imaging. It is configured for simultaneously detecting green and red fluorescent protein signals with scanning laser ophthalmoscopy (SLO) back-scattered light from the SLO illumination beam, and depth information about different retinal layers by means of Optical Coherence Tomography (OCT). Simultaneous assessment of retinal characteristics with different modalities can provide a wealth of information about the structural and functional changes in the retinal neural tissue and chorio-retinal vasculature in vivo. Additionally, simultaneous acquisition of multiple channels facilitates analysis of the data of different modalities by automatic temporal and structural co-registration. As an example of the instrument's performance we imaged the retina of a mouse with constitutive expression of GFP in microglia cells (Cx3cr1GFP/+), and which also expressed the red fluorescent protein mCherry in Müller glial cells by means of adeno-associated virus delivery (AAV2) of an mCherry cDNA driven by the GFAP (glial fibrillary acid protein) promoter.

  14. Combined two-photon microscopy and optical coherence tomography using individually optimized sources

    Science.gov (United States)

    Jeong, Bosu; Lee, Byunghak; Jang, Min Seong; Nam, Hyoseok; Kim, Hae Koo; Yoon, Sang June; Doh, Junsang; Lee, Sang-Joon; Yang, Bo-Gie; Jang, Myoung Ho; Kim, Ki Hean

    2011-03-01

    Two-photon microscopy (TPM) and optical coherence tomography (OCT) are 3D tissue imaging techniques based on different contrast mechanisms. We developed a combined system of TPM and OCT to provide information of both imaging modalities for in-vivo tissue study. TPM and OCT were implemented by using separate light sources, a Ti-Sapphire laser and a wavelength-swept source centered at 1300 nm respectively, and scanners. Light from the two sources was combined for the simultaneous imaging of tissue samples. TPM provided molecular, cellular information of tissues in the region of a few hundred microns on one side at a sub-cellular resolution, and ran at approximately 40 frames per second. OCT provided structural information in the tissue region larger than TPM images at a sub-tenth micron resolution by using 0.1 numerical aperture. OCT had the field of view of 800 um × 800 um based on a 20x objective, the sensitivity of 97dB, and the imaging speed of 0.8 volumes per second. This combined system was tested with simple microsphere specimens, and then was applied to image the explanted intestine of a mouse model and the plant leaves. Morphology and micro-structures of the intestine villi and immune cells within the villi were shown in the intestine image, and chloroplasts and various microstructures of the maize leaves were visualized in 3D by the combined system.

  15. Electron beam bunch length characterizations using incoherent and coherent transition radiation on the APS SASE FEL project

    CERN Document Server

    Lumpkin, Alex H; Berg, W J; Lewellen, J W; Sereno, N S; Happek, U

    2000-01-01

    The Advanced Photon Source (APS) injector linac has been reconfigured with a low-emittance RF thermionic gun and a photocathode (PC) RF gun to support self-amplified spontaneous emission (SASE) free-electron laser (FEL) experiments. One of the most critical parameters for optimizing SASE performance (gain length) is the electron beam peak current, which requires a charge measurement and a bunch length measurement capability. We report here initial measurements of the latter using both incoherent optical transition radiation (OTR) and coherent transition radiation (CTR). A visible light Hamamatsu C5680 synchroscan streak camera was used to measure the thermionic RF gun beam's bunch length (sigma approx 2-3 ps) via OTR generated by the beam at 220 MeV and 200 mA macropulse average current. In addition, a CTR monitor (Michelson Interferometer) based on a Golay cell as the far-infrared (FIR) detector has been installed at the 40-MeV station in the beamline. Initial observations of CTR signal strength variation wi...

  16. Improved contrast for high frame rate imaging using coherent compounding combined with spatial matched filtering.

    Science.gov (United States)

    Lou, Yang; Yen, Jesse T

    2017-07-01

    The concept of high frame rate ultrasound imaging (typically greater than 1000 frames per second) has inspired new fields of clinical applications for ultrasound imaging such as fast cardiovascular imaging, fast Doppler imaging and real-time 3D imaging. Coherent plane-wave compounding is a promising beamforming technique to achieve high frame rate imaging. By combining echoes from plane waves with different angles, dynamic transmit focusing is efficiently accomplished at all points in the image field. Meanwhile, the image frame rate can still be kept at a high level. Spatial matched filtering (SMF) with plane-wave insonification is a novel ultrafast beamforming method. An analytical study shows that SMF is equivalent to synthetic aperture methods that can provide dynamic transmit-receive focusing throughout the field of view. Experimental results show that plane-wave SMF has better performance than dynamic-receive focusing. In this paper, we propose integrating coherent plane-wave compounding with SMF to obtain greater image contrast. By using a combination of SMF beamformed images, image contrast is improved without degrading its high frame rate capabilities. The performance of compounded SMF (CSMF) is evaluated and compared with that of synthetic aperture focusing technique (SAFT) beamforming and compounded dynamic-receive-focus (CDRF) beamforming. The image quality of different beamforming methods was quantified in terms of contrast-to-noise ratio (CNR). Our results show that the new SMF based plane-wave compounding method provides better contrast than DAS based compounding method. Also CSMF can obtain a similar contrast level to dynamic transmit-receive focusing with only 21 transmit events. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. T-junction waveguide-based combining high power microwave beams

    International Nuclear Information System (INIS)

    Zhang Qiang; Yuan Chengwei; Liu Lie

    2011-01-01

    Waveguide-based combining microwave beams is an attractive technique for enhancing the output capacities of narrow-band high power microwave devices. A specific T-junction combiner is designed for combining the X/X band microwave beams, and the detailed combining method and experimental results are presented. In the experiments, two microwave sources which can generate gigawatt level microwaves are driven by a single accelerator simultaneously, and their operation frequencies are 9.41 and 9.60 GHz, respectively. The two microwave beams with durations of about 35 ns have been successfully combined, and no breakdown phenomenon occurs.

  18. Pulse shape and spectrum of coherent diffraction-limited transition radiation from electron beams

    Energy Technology Data Exchange (ETDEWEB)

    van Tilborg, J.; Schroeder, C.B.; Esarey, E.; Leemans, W.P.

    2003-12-20

    The electric field in the temporal and spectral domain of coherent diffraction-limited transition radiation is studied. An electron bunch, with arbitrary longitudinal momentum distribution, propagating at normal incidence to a sharp metal-vacuum boundary with finite transverse dimension is considered. A general expression for the spatiotemporal electric field of the transition radiation is derived, and closed-form solutions for several special cases are given. The influence of parameters such as radial boundary size, electron momentum distribution, and angle of observation on the waveform (e.g., radiation pulse length and amplitude) are discussed. For a Gaussian electron bunch, the coherent radiation waveform is shown to have a single-cycle profile. Application to a novel THz source based on a laser-driven accelerator is discussed.

  19. Optical coherence tomography (OCT) combined with videokeratography to differentiate mild keratoconus subtypes

    Science.gov (United States)

    Rabinowitz, Yaron S.; Li, Xiaohui; Canedo, Ana Laura Caiado; Ambrosio, Renato; Bykhovskaya, Yelena

    2014-01-01

    Background/Aims To develop parameters using a combination of optical coherence tomography (OCT) and videokeratography to ‘early’ detect keratoconus. Methods We performed videokeratography, wavefront analysis and measured OCT indices on 180 normal, 46 moderate keratoconus, 54 early keratoconus, 7 ‘forme fruste’ keratoconus and 16 keratoconus ‘suspect” eyes, to determine the most sensitive parameters for separating these groups. Results A combination of videokeratography and OCT indices (I-S value and Minimum pachymetry) was statistically the most significant in separating the keratoconus groups from normals (Pkeratoconus as being abnormal with 7 normals misclassified (misclassification rate of 2.7%). By adding keratoconus ‘suspects’ to the analysis and an I-S value of 1.2 as a cut of point, we classified 5 ‘suspects’ as normal and 11 normals as abnormal (misclassification rate 7.8%). The PA/I-S index, with a cut of point of 100, reduced this misclassification rate to 4.4%. Conclusion These results suggest that OCT combined with videokeratography may be more useful for differentiating mild forms of keratoconus, than videokeratography alone. PMID:24763472

  20. A Design of High-Power Beam Combiner at Millimeter Wavelengths Utilizing Wire Grids

    Science.gov (United States)

    Lin, Mei; Yu, Yanzhong

    2009-05-01

    A beam combiner, which can combine multiple Gaussian beams into a single one, has many important applications, such as high-power radar and weapon. In this paper, we propose a new scheme of the design of high-power beam combiner at millimeter wavelengths by using wire grids. The design tool is to combine a genetic algorithm (GA) for global optimization and an Ansoft HFSS for rigorous electromagnetic computation. The design method is described in detail and the optimized results are presented. Finally, a brief summary is given.

  1. Beam properties of fully optimized, table-top, coherent source at 30 nm

    Czech Academy of Sciences Publication Activity Database

    Jakubczak, Krzysztof; Mocek, Tomáš; Rus, Bedřich; Polan, Jiří; Hřebíček, Jan; Sawicka, Magdalena; Sikocinski, Pawel; Sobota, Jaroslav; Fořt, Tomáš; Pína, L.

    2011-01-01

    Roč. 19, č. 2 (2011), s. 169-175 ISSN 1230-3402 R&D Projects: GA AV ČR KAN300100702; GA MŠk(CZ) LC528; GA ČR GC202/07/J008 Grant - others:AV ČR(CZ) M100100911 Institutional research plan: CEZ:AV0Z10100523; CEZ:AV0Z20650511 Keywords : laser applications * high−order harmonic generation * coherent extreme ultraviolet radiation * ultrafast optics Subject RIV: BH - Optics, Masers, Lasers Impact factor: 0.966, year: 2011 http://www.springerlink.com/content/y0057067wvw03234/

  2. Performance of a beam-multiplexing diamond crystal monochromator at the Linac Coherent Light Source

    DEFF Research Database (Denmark)

    Zhu, Diling; Feng, Yiping; Stoupin, Stanislav

    2014-01-01

    A double-crystal diamond monochromator was recently implemented at the Linac Coherent Light Source. It enables splitting pulses generated by the free electron laser in the hard x-ray regime and thus allows the simultaneous operations of two instruments. Both monochromator crystals are High......-Pressure High-Temperature grown type-IIa diamond crystal plates with the (111) orientation. The first crystal has a thickness of ∼100 μm to allow high reflectivity within the Bragg bandwidth and good transmission for the other wavelengths for downstream use. The second crystal is about 300 μm thick and makes...

  3. Wavelength beam combining of a 980-nm tapered diode laser bar in an external cavity

    DEFF Research Database (Denmark)

    Vijayakumar, Deepak; Jensen, Ole Bjarlin; Thestrup Nielsen, Birgitte

    2010-01-01

    . By adapting a bar geometry, the output power could be scaled even up to several tens of watts. Unfortunately, the high divergence which is a characteristic feature of the bar geometry could lead to a degradation of the overall beam quality of the laser bar. However, spectral beam combining is an effective...... solution for preserving the beam quality of the bar in the range of that of a single emitter and at the same time, enabling the power scaling. We report spectral beam combining applied to a 12 emitter tapered laser bar at 980 nm. The external cavity has been designed for a wavelength separation of 4.0 nm...

  4. Electron beam characterization of a combined diode rf electron gun

    Directory of Open Access Journals (Sweden)

    R. Ganter

    2010-09-01

    Full Text Available Experimental and simulation results of an electron gun test facility, based on pulsed diode acceleration followed by a two-cell rf cavity at 1.5 GHz, are presented here. The main features of this diode-rf combination are: a high peak gradient in the diode (up to 100  MV/m obtained without breakdown conditioning, a cathode shape providing an electrostatic focusing, and an in-vacuum pulsed solenoid to focus the electron beam between the diode and the rf cavity. Although the test stand was initially developed for testing field emitter arrays cathodes, it became also interesting to explore the limits of this electron gun with metallic photocathodes illuminated by laser pulses. The ultimate goal of this test facility is to fulfill the requirements of the SwissFEL project of Paul Scherrer Institute [B. D. Patterson et al., New J. Phys. 12, 035012 (2010NJOPFM1367-263010.1088/1367-2630/12/3/035012]; a projected normalized emittance below 0.4  μm for a charge of 200 pC and a bunch length of less than 10 ps (rms. A normalized projected emittance of 0.23  μm with 13 pC has been measured at 5 MeV using a Gaussian laser longitudinal intensity distribution on the photocathode. Good agreements with simulations have been obtained for different electron bunch charge and diode geometries. Emittance measurements at a bunch charge below 1 pC were performed for different laser spot sizes in agreement with intrinsic emittance theory [e.g. 0.54  μm/mm of laser spot size (rms for Cu at 274 nm]. Finally, a projected emittance of 1.25+/-0.2  μm was measured with 200 pC and 100  MV/m diode gradient.

  5. High peak current operation of x-ray free-electron laser multiple beam lines by suppressing coherent synchrotron radiation effects

    Science.gov (United States)

    Hara, Toru; Kondo, Chikara; Inagaki, Takahiro; Togawa, Kazuaki; Fukami, Kenji; Nakazawa, Shingo; Hasegawa, Taichi; Morimoto, Osamu; Yoshioka, Masamichi; Maesaka, Hirokazu; Otake, Yuji; Tanaka, Hitoshi

    2018-04-01

    The parallel operation of multiple beam lines is an important means to expand the opportunity of user experiments at x-ray free-electron laser (XFEL) facilities. At SPring-8 Angstrom free-electron laser (SACLA), the multi-beam-line operation had been tested using two beam lines, but transverse coherent synchrotron radiation (CSR) effects at a dogleg beam transport severely limited the laser performance. To suppress the CSR effects, a new beam optics based on two double bend achromat (DBA) structures was introduced for the dogleg. After the replacement of the beam optics, high peak current bunches of more than 10 kA are now stably transported through the dogleg and the laser pulse output is increased by a factor of 2-3. In the multi-beam-line operation of SACLA, the electron beam parameters, such as the beam energy and peak current, can be adjusted independently for each beam line. Thus the laser output can be optimized and wide spectral tunability is ensured for all beam lines.

  6. An All-Fiber-Optic Combined System of Noncontact Photoacoustic Tomography and Optical Coherence Tomography.

    Science.gov (United States)

    Eom, Jonghyun; Shin, Jun Geun; Park, Soongho; Rim, Sunghwan; Lee, Byeong Ha

    2016-05-20

    We propose an all-fiber-based dual-modal imaging system that combines noncontact photoacoustic tomography (PAT) and optical coherence tomography (OCT). The PAT remotely measures photoacoustic (PA) signals with a 1550-nm laser on the surface of a sample by utilizing a fiber interferometer as an ultrasound detector. The fiber-based OCT, employing a swept-source laser centered at 1310 nm, shares the sample arm of the PAT system. The fiber-optic probe for the combined system was homemade with a lensed single-mode fiber (SMF) and a large-core multimode fiber (MMF). The compact and robust common probe is capable of obtaining both the PA and the OCT signals at the same position without any physical contact. Additionally, the MMF of the probe delivers the short pulses of a Nd:YAG laser to efficiently excite the PA signals. We experimentally demonstrate the feasibility of the proposed dual-modal system with a phantom made of a fishing line and a black polyethylene terephthalate fiber in a tissue mimicking solution. The all-fiber-optic system, capable of providing complementary information about absorption and scattering, has a promising potential in minimally invasive and endoscopic imaging.

  7. Differentiation of bacterial versus viral otitis media using a combined Raman scattering spectroscopy and low coherence interferometry probe (Conference Presentation)

    Science.gov (United States)

    Zhao, Youbo; Shelton, Ryan L.; Tu, Haohua; Nolan, Ryan M.; Monroy, Guillermo L.; Chaney, Eric J.; Boppart, Stephen A.

    2016-02-01

    Otitis media (OM) is a highly prevalent disease that can be caused by either a bacterial or viral infection. Because antibiotics are only effective against bacterial infections, blind use of antibiotics without definitive knowledge of the infectious agent, though commonly practiced, can lead to the problems of potential harmful side effects, wasteful misuse of medical resources, and the development of antimicrobial resistance. In this work, we investigate the feasibility of using a combined Raman scattering spectroscopy and low coherence interferometry (LCI) device to differentiate OM infections caused by viruses and bacteria and improve our diagnostic ability of OM. Raman spectroscopy, an established tool for molecular analysis of biological tissue, has been shown capable of identifying different bacterial species, although mostly based on fixed or dried sample cultures. LCI has been demonstrated recently as a promising tool for determining tympanic membrane (TM) thickness and the presence and thickness of middle-ear biofilm located behind the TM. We have developed a fiber-based ear insert that incorporates spatially-aligned Raman and LCI probes for point-of-care diagnosis of OM. As shown in human studies, the Raman probe provides molecular signatures of bacterial- and viral-infected OM and normal middle-ear cavities, and LCI helps to identify depth-resolved structural information as well as guide and monitor positioning of the Raman spectroscopy beam for relatively longer signal acquisition time. Differentiation of OM infections is determined by correlating in vivo Raman data collected from human subjects with the Raman features of different bacterial and viral species obtained from cultured samples.

  8. MO-F-CAMPUS-I-04: Characterization of Fan Beam Coded Aperture Coherent Scatter Spectral Imaging Methods for Differentiation of Normal and Neoplastic Breast Structures

    Energy Technology Data Exchange (ETDEWEB)

    Morris, R; Albanese, K; Lakshmanan, M; Greenberg, J; Kapadia, A [Duke University Medical Center, Durham, NC, Carl E Ravin Advanced Imaging Laboratories, Durham, NC (United States)

    2015-06-15

    Purpose: This study intends to characterize the spectral and spatial resolution limits of various fan beam geometries for differentiation of normal and neoplastic breast structures via coded aperture coherent scatter spectral imaging techniques. In previous studies, pencil beam raster scanning methods using coherent scatter computed tomography and selected volume tomography have yielded excellent results for tumor discrimination. However, these methods don’t readily conform to clinical constraints; primarily prolonged scan times and excessive dose to the patient. Here, we refine a fan beam coded aperture coherent scatter imaging system to characterize the tradeoffs between dose, scan time and image quality for breast tumor discrimination. Methods: An X-ray tube (125kVp, 400mAs) illuminated the sample with collimated fan beams of varying widths (3mm to 25mm). Scatter data was collected via two linear-array energy-sensitive detectors oriented parallel and perpendicular to the beam plane. An iterative reconstruction algorithm yields images of the sample’s spatial distribution and respective spectral data for each location. To model in-vivo tumor analysis, surgically resected breast tumor samples were used in conjunction with lard, which has a form factor comparable to adipose (fat). Results: Quantitative analysis with current setup geometry indicated optimal performance for beams up to 10mm wide, with wider beams producing poorer spatial resolution. Scan time for a fixed volume was reduced by a factor of 6 when scanned with a 10mm fan beam compared to a 1.5mm pencil beam. Conclusion: The study demonstrates the utility of fan beam coherent scatter spectral imaging for differentiation of normal and neoplastic breast tissues has successfully reduced dose and scan times whilst sufficiently preserving spectral and spatial resolution. Future work to alter the coded aperture and detector geometries could potentially allow the use of even wider fans, thereby making coded

  9. Quantum fluid model of coherent stimulated radiation by a dense relativistic cold electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, L. F.; Serbeto, A.; Tsui, K. H. [Instituto de Física, Universidade Federal Fluminense, Campus da Praia Vermelha, Niterói, RJ 24210-346 (Brazil); Mendonça, J. T.; Galvão, R. M. O. [Instituto de Física, Universidade de São Paulo, São Paulo, SP 05508-090 (Brazil)

    2013-07-15

    Using a quantum fluid model, the linear dispersion relation for FEL pumped by a short wavelength laser wiggler is deduced. Subsequently, a new quantum corrected resonance condition is obtained. It is shown that, in the limit of low energy electron beam and low frequency pump, the quantum recoil effect can be neglected, recovering the classical FEL resonance condition, k{sub s}=4k{sub w}γ{sup 2}. On the other hand, for short wavelength and high energy electron beam, the quantum recoil effect becomes strong and the resonance condition turns into k{sub s}=2√(k{sub w}/λ{sub c})γ{sup 3/2}, with λ{sub c} being the reduced Compton wavelength. As a result, a set of nonlinear coupled equations, which describes the quantum FEL dynamics as a three-wave interaction, is obtained. Neglecting wave propagation effects, this set of equations is solved numerically and results are presented.

  10. Spectral beam combining of a 980 nm tapered diode laser bar

    DEFF Research Database (Denmark)

    Vijayakumar, Deepak; Jensen, Ole Bjarlin; Ostendorf, Ralf

    2010-01-01

    We demonstrate spectral beam combining of a 980 nm tapered diode laser bar. The combined beam from 12 tapered emitters on the bar yielded an output power of 9.3 W at 30 A of operating current. An M2 value of 5.3 has been achieved along the slow axis. This value is close to that of a free running...... single tapered emitter on the bar at the same current level. The overall spectral beam combining efficiency was measured to be 63%....

  11. First beam test of a combined ramp and squeeze at LHC

    CERN Document Server

    Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; Gorzawski, Arkadiusz; Redaelli, Stefano; Schaumann, Michaela; Solfaroli Camillocci, Matteo; CERN. Geneva. ATS Department

    2015-01-01

    With increasing maturity of LHC operation it is possible to envisage more complex beam manipulations. At the same time operational efficiency receives increasing attention. So far ramping the beams to their target energy and squeezing the beams to smaller or higher beta are decoupled at the LHC. (De-)squeezing is always performed at the target energy, currently 6.5 TeV. Studies to combine the ramp and squeeze processes have been made for the LHC since 2011, but so far no experimental test with beam had ever performed. This note describes the first machine experiment with beam aiming at validating the combination of ramp and squeeze, the so-called combined ramp and squeeze (CRS).

  12. Combining generalized phase contrast with matched filtering into a versatile beam shaping system

    DEFF Research Database (Denmark)

    Glückstad, Jesper

    2009-01-01

    We adapt concepts from matched filtering to propose a method for generating reconfigurable multiple beams. Combined with the Generalized Phase Contrast (GPC) technique, the proposed method coined mGPC can yield dynamically reconfigurable optical beam arrays with high light efficiency for optical ...

  13. X-ray diffraction and imaging with a coherent beam: application to X-ray optical elements and to crystals exhibiting phase inhomogeneities

    International Nuclear Information System (INIS)

    Masiello, F.

    2011-05-01

    The exceptional properties of synchrotron light sources have been exploited in very different disciplines, from archaeology to chemistry, from material science to biology, from medicine to physics. Among these properties it is important to mention the high brilliance, continuum spectrum, high degree of polarization, time structure, small source size and divergence of the beam, the last resulting in a high transversal coherence of the produced radiation. This high transversal coherence of the synchrotron sources has permitted the development of new techniques, e.g. phase contrast imaging, X-ray photon correlation spectroscopy and coherent X-ray diffraction imaging (CXDI). This thesis work will consist essentially of three parts. In the first part it will be presented the work done as a member of the X-ray Optics Group of ESRF in the characterization of high quality diamond crystals foreseen as X-ray optical elements. The characterization has been done using different complementary X-ray techniques, such as high resolution diffraction, topography, grazing incidence diffraction, reflectivity and measurements of the coherence preservation using the Talbot effect. In the second part, I will show the result obtained in the study of the temperature behaviours of the domain in periodically poled ferroelectrics crystals. This type of measurements, based on Bragg-Fresnel diffraction, are possible only thanks to the high degree of coherence of the beam. In the third part, I will present the results obtained in the characterization of diamonds foreseen for applications other than X-ray optical elements. (author)

  14. High-power beam combining: a step to a future laser weapon system

    Science.gov (United States)

    Protz, Rudolf; Zoz, Jürgen; Geidek, Franz; Dietrich, Stephan; Fall, Michael

    2012-11-01

    Due to the enormous progress in the field of high-power fiber lasers during the last years commercial industrial fiber lasers are now available, which deliver a near-diffraction limited beam with power levels up to10kW. For the realization of a future laser weapon system, which can be used for Counter-RAM or similar air defence applications, a laser source with a beam power at the level of 100kW or more is required. At MBDA Germany the concept for a high-energy laser weapon system is investigated, which is based on such existing industrial laser sources as mentioned before. A number of individual high-power fiber laser beams are combined together, using one common beam director telescope. By this "geometric" beam coupling scheme, sufficient laser beam power for an operational laser weapon system can be achieved. The individual beams from the different lasers are steered by servo-loops, using fast tip-tilt mirrors. This principle enables the concentration of the total laser beam power at the common focal point on a distant target, also allowing fine tracking of target movements and first order compensation of turbulence effects on laser beam propagation. The proposed beam combination concept was demonstrated using several experimental set-ups. Different experiments were performed, to investigate laser beam target interaction and target fine tracking also at large distances. Content and results of these investigations are reported. An example for the lay-out of an Air Defence High Energy Laser Weapon (ADHELW ) is given. It can be concluded, that geometric high-power beam combining is an important step for the realization of a laser weapon system in the near future.

  15. Coherent Diffraction Radiation as a Tool for Longitudinal Beam Profile Diagnostics at CTF3

    CERN Document Server

    Lekomtsev, K; Boorman, G E; Karataev, V; Micheler, M; Corsini, R; Lefèvre, T

    2010-01-01

    Com­pact Lin­ear Col­lid­er (CLIC) is a mul­ti-TeV elec­tron-positron col­lid­er for par­ti­cle physics based on an in­no­va­tive two-beam ac­cel­er­a­tion scheme. The CLIC Test Fa­cil­i­ty 3 (CTF3, CERN) aims to demon­strate fea­si­bil­i­ty of this con­cept. The mon­i­tor­ing of a lon­gi­tu­di­nal pro­file will be very im­por­tant for the CLIC. The op­ti­miza­tion of the lon­gi­tu­di­nal charge dis­tri­bu­tion in a bunch is cru­cial for the max­imi­sa­tion of the lu­mi­nos­i­ty and also for an op­ti­mal per­for­mance of a CLIC drive beam. A setup for the in­ves­ti­ga­tion of Co­her­ent Diffrac­tion Ra­di­a­tion (CDR) from tar­gets with var­i­ous con­fig­u­ra­tions as a tool for non-in­va­sive lon­gi­tu­di­nal elec­tron beam pro­file di­ag­nos­tics has been de­signed and in­stalled in the CRM line of the CTF3 [1, 2]. In this re­port we pre­sent the sta­tus of the ex­per­i­ment and re­sults on in­ter­fer­o­met­r...

  16. Coherent Structures and Chaos Control in High-Power Microwave and Charged-Particle Beam Devices

    Science.gov (United States)

    2009-01-31

    gating through a periodic solenoidal magnetic focusing field. For continuous beams with long pulses , the longitudinal en- ergy spread is small such...0.2 (cw) 10 ( pulsed ) Current (A) 0.11 111.1 Voltage (kV) 2.29 120 a/b 6.0 20 a (cm) 0.373 1.0 S (cm) 1.912 2.2 koy /box 6.0 20 BQ (kG) 0.263 2.0...envelope equations are d2a b2[a2-2axayJ+a 2aj 2K a2-b2 ds’ (a + b) • 2yJKz (s) ava + 2L_ a = 0. YbPbmc d2b a2\\a2v-2axav)+b 2a2 2K ~ rT\\ u

  17. Combined e-beam lithography using different energies

    Czech Academy of Sciences Publication Activity Database

    Krátký, Stanislav; Kolařík, Vladimír; Horáček, Miroslav; Meluzín, Petr; Král, Stanislav

    2017-01-01

    Roč. 177, JUN (2017), s. 30-34 ISSN 0167-9317 R&D Projects: GA TA ČR TE01020233; GA MŠk(CZ) LO1212; GA MŠk ED0017/01/01 Institutional support: RVO:68081731 Keywords : grayscale e-beam lithography * mix and match process * absorbed energy density * resist sensitivity * micro-optical elements Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering OBOR OECD: Nano-processes (applications on nano-scale) Impact factor: 1.806, year: 2016

  18. High-power direct diode laser output by spectral beam combining

    Science.gov (United States)

    Tan, Hao; Meng, Huicheng; Ruan, Xu; Du, Weichuan; Wang, Zhao

    2018-03-01

    We demonstrate a spectral beam combining scheme based on multiple mini-bar stacks, which have more diode laser combining elements, to increase the combined diode laser power and realize equal beam quality in both the fast and slow axes. A spectral beam combining diode laser output of 1130 W is achieved with an operating current of 75 A. When a 9.6 X de-magnifying telescope is introduced between the output mirror and the diffraction grating, to restrain cross-talk among diode laser emitters, a 710 W spectral beam combining diode laser output is achieved at the operating current of 70 A, and the beam quality on the fast and slow axes of the combined beam is about 7.5 mm mrad and 7.3 mm mrad respectively. The power reduction is caused by the existence of a couple resonator between the rear facet of the diode laser and the fast axis collimation lens, and it should be eliminated by using diode laser chips with higher front facet transmission efficiency and a fast axis collimation lens with lower residual reflectivity.

  19. A Plasma Based Beam Combiner for Very High Fluence and Energy

    Science.gov (United States)

    Kirkwood, Robert

    2017-10-01

    Recent work at NIF has demonstrated a plasma-based optic that combines the energy and fluence of many laser beams into a single bright beam, thus creating a new technique for designing future high energy density physics experiments. The technique uses the Cross Beam Energy Transfer (CBET) process and shows for the first time that a plasma can combine beams to produce a single beam that emerges with energy and fluence beyond that of any of those input for delivery to a range of experimental targets. In an initial demonstration multiple beams of the National Ignition Facility (NIF) laser have been combined in a plasma to produce a directed pulse of light with 4 +1 kJ of energy in its 1 ns duration which is 3.6 times the energy and 3.2 times the fluence of any of the incident beams during that period and is NIFs brightest 1ns duration beam of UV light. These enhancements are due to the non-linear interaction of the beams with a self-generated plasma diffractive optic which is far more damage resistant than existing solid state optics, and is inherently capable of producing much higher single beam fluence and radiance than solid state refractive or reflective optics can. The initial results are presently being used to further validate models of CBET which predict a larger number of non-resonant pump beams will scale up outputs still further. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  20. Development of high damage threshold multilayer thin film beam combiner for laser application

    Energy Technology Data Exchange (ETDEWEB)

    Nand, Mangla, E-mail: mnand@rrcat.gov.in; Babita,; Jena, S.; Tokas, R. B.; Rajput, P.; Thakur, S.; Jha, S. N.; Sahoo, N. K. [Atomic& Molecular Physics Division, Bhabha Atomic research Centre, Mumbai-400 085 (India); Mukharjee, C. [Mechanical and Optics Services Section, Raja Ramanna Centre for Advanced Technology, Indore, 452 013 (India)

    2016-05-23

    A polarized wavelength multiplexer with high laser induced damage threshold has been developed to combine two laser beam of high peak power in the visible region. The present wavelength multiplexer is a multilayer thin film device deposited by reactive electron beam evaporation. The developed device is capable of combining two p-polarized laser beams of peak power density of 1.7 GW/cm{sup 2} at an angle of incidence of 45°. High transmission (T> 90%) in high pass region and high reflection (R> 99%) in stop band region have been achieved.

  1. Differentiation of Basal Cell Carcinoma Subtypes in Multi-Beam Swept Source Optical Coherence Tomography (MSS-OCT).

    Science.gov (United States)

    Meekings, Adam; Utz, Sarah; Ulrich, Martina; Bienenfeld, Amanda; Nandanan, Naveen; Fisher, Juliya; McKenzie, Gordon; Siegel, Daniel M; Feldman, Eleanor; Markowitz, Orit

    2016-05-01

    Optical coherence tomography (OCT) is a technique that enables real-time in-vivo examination of tissue. This technology provides the clinician with the potential to use a non-invasive tool in the identification and diagnosis of many skin lesions. However, the diagnostic features of basal cell carcinoma have not yet been described with comparison to their histopathology. To identify and describe key features of basal cell carcinoma (BCC) and its subtypes as they present in multi-beam Swept Source - OCT (MSS-OCT), and to correlate those against conventional histopathology. A total of 40 lesions were assessed by MSS-OCT prior to biopsy. 60-slice OCT images of the lesions were obtained and correlated with histology sections taken in the same plane. OCT scans were assessed retrospectively by a panel to determine the OCT criteria for BCC and its subtypes. The following diagnostic criteria were identified: hyporeflective ovoid structures (40/40), dark halo boundaries (38/40), epidermal thinning (28/40), and collagen compression (14/40). Lesional tissue also showed a destruction of layers when compared to the surrounding normal tissue. In addition to the shared criteria, other subtypes showed distinct diagnostic criteria. With its higher sensitivity, using MSS-OCT allowed for non-invasive, accurate identification of the key diagnostic features of BCC and its subtypes with high correlation to the histopathologic features found with biopsy. J Drugs Dermatol. 2016;15(5):545-550.

  2. The FERMI@Elettra free-electron-laser source for coherent X-ray physics: photon properties, beam transport system, and applications

    Energy Technology Data Exchange (ETDEWEB)

    Allaria, Enrico; Callegari, Carlo; Cocco, Daniele; Fawley, William M.; Kiskinova, Maya; Masciovecchio, Claudio; Parmigiani, Fulvio

    2010-04-05

    FERMI@Elettra is comprised of two free electron lasers (FELs) that will generate short pulses (tau ~;; 25 to 200 fs) of highly coherent radiation in the XUV and soft X-ray region. The use of external laser seeding together with a harmonic upshift scheme to obtain short wavelengths will give FERMI@Elettra the capability to produce high quality, longitudinal coherent photon pulses. This capability together with the possibilities of temporal synchronization to external lasers and control of the output photon polarization will open new experimental opportunities not possible with currently available FELs. Here we report on the predicted radiation coherence properties and important configuration details of the photon beam transport system. We discuss the several experimental stations that will be available during initial operations in 2011, and we give a scientific perspective on possible experiments that can exploit the critical parameters of this new light source.

  3. Monitoring adipose-derived stem cells within 3D carrier by combined dielectric spectroscopy and spectral domain optical coherence topography

    Science.gov (United States)

    Bagnaninchi, P. O.

    2010-02-01

    Monitoring non-invasively the cellular events in three dimensional carriers is a major challenge for tissue engineering and regenerative medicine that prevents time-lapsed studies over large population of sample. The potential of optical coherence tomography has been demonstrated to assess tissue formation within porous matrices. In this study we explore the combination of dielectric spectroscopy (DS) and spectral domain optical coherence tomography (SDOCT) to quality assess ADSCs loaded in three dimensional carriers. A SDOCT (930nm, FWHM 90nm) was combined to an open ended coaxial probe connected to material analyser, and broadband measurements between 20MHz and 1GHz were synchronized with Labview. Both ADSCs maintained in undifferentiated state within 3D carrier and induced towards osteoblasts were monitored with this multimodality technique and their DS spectra were acquired at high cell concentration simultaneously to 3D imaging. This multimodality technique will be instrumental to assess non-invasively cell loaded carriers for cell therapy.

  4. A method for measuring coherent elastic neutrino-nucleus scattering at a far off-axis high-energy neutrino beam target

    Energy Technology Data Exchange (ETDEWEB)

    Brice, S. J. [Fermilab; Cooper, R. L. [Indiana U.; DeJongh, F. [Fermilab; Empl, A. [Houston U.; Garrison, L. M. [Indiana U.; Hime, A. [Los Alamos; Hungerford, E. [Houston U.; Kobilarcik, T. [Fermilab; Loer, B. [Fermilab; Mariani, C. [Virginia Tech.; Mocko, M. [Los Alamos; Muhrer, G. [Los Alamos; Pattie, R. [North Carolina State U.; Pavlovic, Z. [Los Alamos; Ramberg, E. [Fermilab; Scholberg, K. [Duke U.; Tayloe, R. [Indiana U.; Thornton, R. T. [Indiana U.; Yoo, J. [Fermilab; Young, A. [North Carolina State U.

    2014-04-03

    We present an experimental method for measuring the process of coherent elastic neutrino-nucleus scattering (CENNS). This method uses a detector situated transverse to a high-energy neutrino beam production target. This detector would be sensitive to the low-energy neutrinos arising from decay-at-rest pions in the target. We discuss the physics motivation for making this measurement and outline the predicted backgrounds and sensitivities using this approach. We report a measurement of neutron backgrounds as found in an off-axis surface location of the Fermilab Booster Neutrino Beam (BNB) target. The results indicate that the Fermilab BNB target is a favorable location for a CENNS experiment.

  5. Simulation of Electron Beam Dynamics in the 22 MeV Accelerator for a Coherent Electron Cooling Proof of Principle Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Owen, Justin [Stony Brook Univ., NY (United States)

    2013-12-01

    Coherent electron cooling (CeC) offers a potential new method of cooling hadron beams in colliders such as the Relativistic Heavy Ion Collider (RHIC) or the future electron ion collider eRHIC. A 22 MeV linear accelerator is currently being built as part of a proof of principle experiment for CeC at Brookhaven National Laboratory (BNL). In this thesis we present a simulation of electron beam dynamics including space charge in the 22 MeV CeC proof of principle experiment using the program ASTRA (A Space charge TRacking Algorithm).

  6. Beam-beam and impedance

    CERN Document Server

    White, S.

    2014-07-17

    As two counter-rotating beams interact they can give rise to coherent dipole modes. Under the influence of impedance these coherent beam-beam modes can couple to higher order head-tail modes and lead to strong instabilities. A fully self-consistent approach including beam-beam and impedance was used to characterize this new coupled mode instability and study possible cures such as a transverse damper and high chromaticity.

  7. Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope.

    Science.gov (United States)

    Wells-Gray, Elaine M; Choi, Stacey S; Zawadzki, Robert J; Finn, Susanna C; Greiner, Cherry; Werner, John S; Doble, Nathan

    2018-03-01

    We have designed and implemented a dual-mode adaptive optics (AO) imaging system that combines spectral domain optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) for in vivo imaging of the human retina. The system simultaneously acquires SLO frames and OCT B-scans at 60 Hz with an OCT volume acquisition time of 4.2 s. Transverse eye motion measured from the SLO is used to register the OCT B-scans to generate three-dimensional (3-D) volumes. Key optical design considerations include: minimizing system aberrations through the use of off-axis relay telescopes, conjugate pupil plane requirements, and the use of dichroic beam splitters to separate and recombine the OCT and SLO beams around the nonshared horizontal scanning mirrors. To demonstrate system performance, AO-OCT-SLO images and measurements are taken from three normal human subjects ranging in retinal eccentricity from the fovea out to 15-deg temporal and 20-deg superior. Also presented are en face OCT projections generated from the registered 3-D volumes. The ability to acquire high-resolution 3-D images of the human retina in the midperiphery and beyond has clinical importance in diseases, such as retinitis pigmentosa and cone-rod dystrophy. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

  8. Early experience of proton beam therapy combined with chemotherapy for locally advanced oropharyngeal cancer

    International Nuclear Information System (INIS)

    Ishikawa, Youjirou; Nakamura, Tatsuya; Takada, Akinori; Takayama, Kanako; Makita, Chiyoko; Suzuki, Motohisa; Azami, Yusuke; Kikuchi, Yasuhiro; Fuwa, Nobukazu

    2013-01-01

    Between 2009 and 2012, 10 patients with advanced oropharyngeal cancer underwent proton therapy combined with chemotherapy. The initial results of this therapy were 8 complete response (CR) and 2 partial response (PR), local recurrence was detected 1 patient. Proton beam therapy combined with chemotherapy is thought to be an effective treatment for locally advanced oropharyngeal cancer. (author)

  9. Adaptive optics scanning laser ophthalmoscopy in combination with en-face optical coherence tomography

    International Nuclear Information System (INIS)

    Felberer, F.

    2014-01-01

    The human retina is a most important tissue and plays a fundamental role for the vision. Diseases of the eye affect the normal retinal function which, if untreated, may lead to vision loss or ultimately to blindness. Thus, in vivo diagnostic tools that provide detailed information on the retinal status are required in order to improve diagnosis and treatment. In recent years, several new optical imaging methods of the human retina have been developed and now represent the key part in a standard ophthalmic examination process. One of these technologies is optical coherence tomography (OCT), which provides images of the retina noninvasively and with a high axial resolution. However, imperfections of the eye's optics cause aberrations of the wavefront of the imaging light, thus limiting the transverse resolution of such systems. Improvements in the resolution of retinal images are necessary to resolve individual cells (e.g. photoreceptors) which may provide new opportunities in retinal diagnostics and therapy control. Adaptive optics (AO), a technology known from astronomy, may be used to increase image resolution. Aberrations of the imaging light are measured and corrected, resulting in an increase of lateral resolution up to the diffraction limit. Within this thesis, AO was combined with a scanning laser ophthalmoscope (SLO) that enables high resolution imaging of the retina. Measurements on healthy subjects demonstrated the ability of the system to resolve foveal cones (the smallest cone photoreceptors within the retina) and even rod photoreceptors. However, the depth resolution of the system remained limited compared to OCT instruments. Thus, in a second step, the instrument was extended to a combined AO-SLO/OCT system. The OCT system is based on transversal scanning (TS)-OCT which records en-face images of the retina and incorporates a high-speed axial eye tracking device. Together with transverse motion correction based on the AO-SLO images, the system

  10. Gaussian cloning of coherent states with known phases

    International Nuclear Information System (INIS)

    Alexanian, Moorad

    2006-01-01

    The fidelity for cloning coherent states is improved over that provided by optimal Gaussian and non-Gaussian cloners for the subset of coherent states that are prepared with known phases. Gaussian quantum cloning duplicates all coherent states with an optimal fidelity of 2/3. Non-Gaussian cloners give optimal single-clone fidelity for a symmetric 1-to-2 cloner of 0.6826. Coherent states that have known phases can be cloned with a fidelity of 4/5. The latter is realized by a combination of two beam splitters and a four-wave mixer operated in the nonlinear regime, all of which are realized by interaction Hamiltonians that are quadratic in the photon operators. Therefore, the known Gaussian devices for cloning coherent states are extended when cloning coherent states with known phases by considering a nonbalanced beam splitter at the input side of the amplifier

  11. Adaptive Jamming Suppression in Coherent FFH System Using Weighted Equal Gain Combining Receiver over Fading Channels with Imperfect CSI

    Directory of Open Access Journals (Sweden)

    Yishan He

    2015-01-01

    Full Text Available Fast frequency hopping (FFH is commonly used as an antijamming communication method. In this paper, we propose efficient adaptive jamming suppression schemes for binary phase shift keying (BPSK based coherent FFH system, namely, weighted equal gain combining (W-EGC with the optimum and suboptimum weighting coefficient. We analyze the bit error ratio (BER of EGC and W-EGC receivers with partial band noise jamming (PBNJ, frequency selective Rayleigh fading, and channel estimation errors. Particularly, closed-form BER expressions are presented with diversity order two. Our analysis is verified by simulations. It is shown that W-EGC receivers significantly outperform EGC. As compared to the maximum likelihood (ML receiver in conventional noncoherent frequency shift keying (FSK based FFH, coherent FFH/BPSK W-EGC receivers also show significant advantages in terms of BER. Moreover, W-EGC receivers greatly reduce the hostile jammers’ jamming efficiency.

  12. Laser beam joining of material combinations for automotive applications

    Science.gov (United States)

    Schubert, Emil; Zerner, Ingo; Sepold, Gerd

    1997-08-01

    An ideal material for automotive applications would combine the following properties: high corrosion resistance, high strength, high stiffness and not at least a low material price. Today a single material is not able to meet all these requirements. Therefore, in the future different materials will be placed where they meet the requirements best. The result of this consideration is a car body with many different alloys and metals, which have to be joined to one another. BIAS is working on the development of laser based joining technologies for different material combinations, especially for thin sheets used in automotive applications. One result of the research is a joining technology for an aluminum-steel-joint. Using a Nd:YAG laser the problem of brittle intermetallic phases between these materials was overcome. Using suitable temperature-time cycles, elected by a FEM-simulation, the thickness of intermetallic phases was kept below 10 micrometers . This technology was also applied to coated steels, which were joined with different aluminum alloys. Further it is demonstrated that titanium alloys, e.g. used for racing cars, can also be joined with aluminum alloys.

  13. The optical design of the QUBIC beam combiner

    Science.gov (United States)

    Gayer, Donnacha; Bennett, David; O'Sullivan, Créidhe; Scully, Stephen; Curran, Gareth; Hamilton, Jean-Christophe; Bigot-Sazy, Marie-Anne; Piat, Michel; Kaplan, Jean; Tartari, Andrea; Gervasi, Massimo; Zannoni, Mario

    2012-09-01

    The Q and U Bolometric Interferometer for Cosmology (QUBIC) is a ground-based interferometer that aims to meet one of the major challenges of modern cosmology in the detection of B-mode polarization anisotropies in the Cosmic Microwave Background.B-mode anisotropies originate from tensor fluctuations of the metric produced during the inflationary phase of the early Universe. Their detection would therefore constitute a major step towards understanding the primordial Universe. The expected level of these anisotropies is however so small that detection requires instruments with high sensitivity and extremely good control of systematic effects. The QUBIC instrument is based on the novel concept of bolometric interferometry, and exploits the sensitivity advantages of bolometric detectors along with the greater control of systematics offered by interferometry.The instrument will directly observe the sky through an array of entry horns whose signals will be combined optically onto an array of bolometers cooled to around 300mK. The whole set-up is located inside a cryostat. The sensitivity of the instrument is maximised if equivalent baselines produce identical fringe patterns on the focal plane. This requires the minimization of wavefront aberrations for a wide field-of-view and a fast system.In this poster we present the quasi-optical design and analysis of the dual reflector designed to do this. We report on the loss of sensitivity for different levels of optical aberration in the combiner. The sensitivity of the QUBIC instrument is comparable with that of an imager with the same number of horns but with much greater control over systematics.

  14. Scintillation and bit error rate analysis of a phase-locked partially coherent flat-topped array laser beam in oceanic turbulence.

    Science.gov (United States)

    Yousefi, Masoud; Kashani, Fatemeh Dabbagh; Golmohammady, Shole; Mashal, Ahmad

    2017-12-01

    In this paper, the performance of underwater wireless optical communication (UWOC) links, which is made up of the partially coherent flat-topped (PCFT) array laser beam, has been investigated in detail. Providing high power, array laser beams are employed to increase the range of UWOC links. For characterization of the effects of oceanic turbulence on the propagation behavior of the considered beam, using the extended Huygens-Fresnel principle, an analytical expression for cross-spectral density matrix elements and a semi-analytical one for fourth-order statistical moment have been derived. Then, based on these expressions, the on-axis scintillation index of the mentioned beam propagating through weak oceanic turbulence has been calculated. Furthermore, in order to quantify the performance of the UWOC link, the average bit error rate (BER) has also been evaluated. The effects of some source factors and turbulent ocean parameters on the propagation behavior of the scintillation index and the BER have been studied in detail. The results of this investigation indicate that in comparison with the Gaussian array beam, when the source size of beamlets is larger than the first Fresnel zone, the PCFT array laser beam with the higher flatness order is found to have a lower scintillation index and hence lower BER. Specifically, in the sense of scintillation index reduction, using the PCFT array laser beams has a considerable benefit in comparison with the single PCFT or Gaussian laser beams and also Gaussian array beams. All the simulation results of this paper have been shown by graphs and they have been analyzed in detail.

  15. Multi-Aperture Digital Coherent Combining for Free-Space Optical Communication Receivers

    Science.gov (United States)

    2016-04-21

    723), 456-458 (1996). 1. Introduction Future space platforms, whether they are near-Earth satellites or probes to the moon or other planets...error correction (FEC), and high-performance photo -detection with low implementation loss. Recent results have demonstrated receiver sensitivities...lightwave circuit. Fig. 6. Photo of a single preamplified coherent receiver mounted on a 12” × 12” optical breadboard. Fig. 4(b) shows the parallel

  16. Rapid diagnosis and differentiation of microbial pathogens in otitis media with a combined Raman spectroscopy and low-coherence interferometry probe: toward in vivo implementation

    Science.gov (United States)

    Zhao, Youbo; Monroy, Guillermo L.; You, Sixian; Shelton, Ryan L.; Nolan, Ryan M.; Tu, Haohua; Chaney, Eric J.; Boppart, Stephen A.

    2016-10-01

    We investigate and demonstrate the feasibility of using a combined Raman scattering (RS) spectroscopy and low-coherence interferometry (LCI) probe to differentiate microbial pathogens and improve our diagnostic ability of ear infections [otitis media (OM)]. While the RS probe provides noninvasive molecular information to identify and differentiate infectious microorganisms, the LCI probe helps to identify depth-resolved structural information as well as to guide and monitor positioning of the Raman spectroscopy beam for relatively longer signal acquisition times. A series of phantom studies, including the use of human middle ear effusion samples, were performed to mimic the conditions of in vivo investigations. These were also conducted to validate the feasibility of using this combined RS/LCI probe for point-of-care diagnosis of the infectious pathogen(s) in OM patients. This work establishes important parameters for future in vivo investigations of fast and accurate determination and diagnosis of infectious microorganisms in OM patients, potentially improving the efficacy and outcome of OM treatments, and importantly reducing the misuse of antibiotics in the presence of viral infections.

  17. SPECT reconstruction of combined cone beam and parallel hole collimation with experimental data

    International Nuclear Information System (INIS)

    Li, Jianying; Jaszczak, R.J.; Turkington, T.G.; Greer, K.L.; Coleman, R.E.

    1993-01-01

    The authors have developed three methods to combine parallel and cone bean (P and CB) SPECT data using modified Maximum Likelihood-Expectation Maximization (ML-EM) algorithms. The first combination method applies both parallel and cone beam data sets to reconstruct a single intermediate image after each iteration using the ML-EM algorithm. The other two iterative methods combine the intermediate parallel beam (PB) and cone beam (CB) source estimates to enhance the uniformity of images. These two methods are ad hoc methods. In earlier studies using computer Monte Carlo simulation, they suggested that improved images might be obtained by reconstructing combined P and CB SPECT data. These combined collimation methods are qualitatively evaluated using experimental data. An attenuation compensation is performed by including the effects of attenuation in the transition matrix as a multiplicative factor. The combined P and CB images are compared with CB-only images and the result indicate that the combined P and CB approaches suppress artifacts caused by truncated projections and correct for the distortions of the CB-only images

  18. Coherent and non coherent atom optics experiment with an ultra-narrow beam of metastable rare gas atoms; Experiences d'optique atomique coherente ou non avec un jet superfin d'atomes metastables de gaz rares

    Energy Technology Data Exchange (ETDEWEB)

    Grucker, J

    2007-12-15

    In this thesis, we present a new type of atomic source: an ultra-narrow beam of metastable atoms produced by resonant metastability exchange inside a supersonic beam of rare gas atoms. We used the coherence properties of this beam to observe the diffraction of metastable helium, argon and neon atoms by a nano-transmission grating and by micro-reflection-gratings. Then, we evidenced transitions between Zeeman sublevels of neon metastable {sup 3}P{sub 2} state due to the quadrupolar part of Van der Waals potential. After we showed experimental proofs of the observation of this phenomenon, we calculated the transition probabilities in the Landau - Zener model. We discussed the interest of Van der Waals - Zeeman transitions for atom interferometry. Last, we described the Zeeman cooling of the supersonic metastable argon beam ({sup 3}P{sub 2}). We have succeeded in slowing down atoms to speeds below 100 m/s. We gave experimental details and showed the first time-of-flight measurements of slowed atoms.

  19. Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry.

    Science.gov (United States)

    Yanina, Irina Y; Popov, Alexey P; Bykov, Alexander V; Meglinski, Igor V; Tuchin, Valery V

    2018-01-01

    Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24°C to 60°C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great potential as an alternative method for obtaining accurate information on the processes occurring during thermal lipolysis. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

  20. Treatment of liquid separated from sludge by the method using electron beam and ozone in combination

    International Nuclear Information System (INIS)

    Hosono, Masakazu; Arai, Hidehiko; Aizawa, Masaki; Shimooka, Toshio; Shimizu, Ken; Sugiyama, Masashi.

    1995-01-01

    Since the liquid separated from sludge in the dehydration or concentration process of sewer sludge contains considerable amount of organic compositions that are hard to be decomposed by microorganisms, it has become difficult to be treated by conventional activated sludge process. In the case of discharging the separated liquid into closed water areas, the higher quality treatment is required. The method of using electron beam irradiation and ozone oxidation in combination for cleaning the liquid separated from sludge was examined, therefore, the results are reported. The water quality of the sample from the sludge treatment plant in A City is shown. The method of bio-pretreatment, the treatment method by using electron beam and ozone in combination, and the method of analyzing the water quality are described. The effect of the treatment by activated sludge process, as the effect of the treatment by the combined use of electron beam and ozone, the change of COD and TOC, the change of chromaticity, the change of gel chromatogram, and the reaction mechanism are reported. In this paper, only the basic concept on the model plant for applying the method of the combined use of electron beam and ozone to the treatment of the liquid separated from sludge is discussed. (K.I.)

  1. Study of the ATLAS MDT spectrometer using high energy CERN combined test beam data

    NARCIS (Netherlands)

    Adorisio, C.; et al., [Unknown; Barisonzi, M.; Bobbink, G.; Boterenbrood, H.; Brouwer, G.; Groenstege, H.; Hart, R.; Konig, A.; Linde, F.; van der Graaf, H.; Vermeulen, J.; Vreeswijk, M.; Werneke, P.

    2009-01-01

    In 2004, a combined system test was performed in the H8 beam line at the CERN SPS with a setup reproducing the geometry of sectors of the ATLAS Muon Spectrometer, formed by three stations of Monitored Drift Tubes (MDT). The full ATLAS analysis chain was used to obtain the results presented in this

  2. A large capacity time division multiplexed (TDM) laser beam combining technique enabled by nanosecond speed KTN deflector

    Science.gov (United States)

    Yin, Stuart (Shizhuo); Chao, Ju-Hung; Zhu, Wenbin; Chen, Chang-Jiang; Campbell, Adrian; Henry, Michael; Dubinskiy, Mark; Hoffman, Robert C.

    2017-08-01

    In this paper, we present a novel large capacity (a 1000+ channel) time division multiplexing (TDM) laser beam combining technique by harnessing a state-of-the-art nanosecond speed potassium tantalate niobate (KTN) electro-optic (EO) beam deflector as the time division multiplexer. The major advantages of TDM approach are: (1) large multiplexing capability (over 1000 channels), (2) high spatial beam quality (the combined beam has the same spatial profile as the individual beam), (3) high spectral beam quality (the combined beam has the same spectral width as the individual beam, and (4) insensitive to the phase fluctuation of individual laser because of the nature of the incoherent beam combining. The quantitative analyses show that it is possible to achieve over one hundred kW average power, single aperture, single transverse mode solid state and/or fiber laser by pursuing this innovative beam combining method, which represents a major technical advance in the field of high energy lasers. Such kind of 100+ kW average power diffraction limited beam quality lasers can play an important role in a variety of applications such as laser directed energy weapons (DEW) and large-capacity high-speed laser manufacturing, including cutting, welding, and printing.

  3. Broadband feedback systems for the damping of coherent beam instabilities in the stretcher ring ELSA; Breitbandige Feedback-Systeme zur Daempfung kohaerenter Strahlinstabilitaeten am Stretcherring ELSA

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Andre

    2012-12-15

    At the Electron Stretcher Facility ELSA an upgrade of the internal beam current up to 200 mA would be desirable in order to increase the intensity of the extracted electron beam for the future experimental hadron physics program. However, such an upgrade is mainly limited by the excitation of coherent beam instabilities in the stretcher ring. As active counteraction, broadband bunch-by-bunch feedback-systems for the longitudinal, as well as for both transverse planes were installed. After detection of the motion of each of the 27 4 stored bunches via beam position monitors, the systems determine independent correction signals for each bunch using digital signal processors. The amplified correction signals are applied to the beam by means of broadband longitudinal and transverse kicker structures. The detailed setup, the commissioning procedure and measurement results of the damping performance of the systems are presented. In addition, the operation of the longitudinal system during the fast energy ramp of 4 GeV/s from 1.2 GeV to 3.2 GeV is investigated.

  4. Towards 3D-photonic, multi-telescope beam combiners for mid-infrared astrointerferometry

    Science.gov (United States)

    Diener, Romina; Tepper, Jan; Labadie, Lucas; Pertsch, Thomas; Nolte, Stefan; Minardi, Stefano

    2017-08-01

    In the past two decades high precision optical astronomical interferometry has benefited from the use of photonic technologies. Today, near-infrared interferometric instruments deliver high-resolution, hyperspectral images of astronomical objects and combine up to 4 independent telescopes at a time thanks to integrated optics (IO). Following the success of IO interferometry, several initiatives aim at developing components which could combine simultaneously more telescopes and extend their operation beyond the near-infrared bands. Here we report on the development of multi-telescope IO beam combiners for mid-infrared interferometry exploiting the three-dimensional (3D) structuring capabilities of ultrafast laser inscription. We characterise the capability of a 2-telescope and a 4-telescope beam combiner to retrieve the visibility amplitude and phase of monochromatic light fields at a wavelength of 3.39 μm. The combiner prototypes exploit different 3D architectures and are written with a femtosecond laser on substrates of Gallium Lanthanum Sulfide. Supporting numerical simulations of the performance of the beam combiners show that there is still room for improvement and indicate a roadmap for the development of future prototypes.

  5. 2D Idealisation of Hollow Reinforced Concrete Beams Subjected to Combined Torsion, Bending and Shear

    Directory of Open Access Journals (Sweden)

    A.S. Al-Nuaimi

    2005-12-01

    Full Text Available This paper presents a finite element model for idealisation of reinforced concrete hollow beams using 2D plane elements. The method of ensuring compatibility between the plates using two-dimensional model to analyze this type of structures is discussed. Cross-sectional distortion was minimised by incorporating end diaphragms in the FE model. Experimental results from eight reinforced concrete hollow beams are compared with the non-linear predictions produced by a 2D in-house FE program. The beam dimensions were 300x300 mm cross section with 200x200 mm hollow core and 3800 mm long. The beam ends were filled with concrete to form solid end diaphragms to prevent local distortion. The beams were subjected to combined bending, torsion and shear. It was found that the two-dimensional idealisation of hollow beams is adequate provided that compatibility of displacements between adjoining plates along the line of intersection is maintained and the cross-sectional distortion is reduced to minimum. The results from the 2D in-house finite element program showed a good agreement with experimental results.

  6. Direct Design of T-Beams for Combined Load of Bending and Torsion

    Directory of Open Access Journals (Sweden)

    A. S. Alnuaimi

    2007-12-01

    Full Text Available Tests were conducted on five reinforced concrete T-beams subjected to combined load of bending and torsion. Elastic stress field in conjunction with Nielsen's 2D yield criterion for reinforced concrete subjected to in-plane forces were used in the Direct Design Method for the design of reinforcement. The beam dimensions were: flange width = 600mm, flange thickness = 150mm, web width = 200mm, total depth = 600mm and beam length = 5.2m. Required reinforcement calculated using the Direct Design Method was compared with the ACI and BSI codes. It was found that the Direct Design Method requires longitudinal reinforcement similar to the ACI code but less than the BSI code. In the transverse direction, the Direct Design Method requires much less reinforcement than both codes. The main variable studied was the ratio of the maximum twisting moment to the bending moment which was varied between 0.6 and 1.5. Good agreement was found between the design and experimental failure loads. Most of the longitudinal and transverse steel yielded or reached near yield stress when the design load was approached. All beams failed near the design loads and undergone ductile behaviour until failure. The results indicate that the Direct Design Method can be successfully used to design reinforced concrete T-beams for the combined effect of bending and torsion loads.

  7. Fast Transverse Beam Instability Caused by Electron Cloud Trapped in Combined Function Magnets

    Energy Technology Data Exchange (ETDEWEB)

    Antipov, Sergey [Univ. of Chicago, IL (United States)

    2017-03-01

    Electron cloud instabilities affect the performance of many circular high-intensity particle accelerators. They usually have a fast growth rate and might lead to an increase of the transverse emittance and beam loss. A peculiar example of such an instability is observed in the Fermilab Recycler proton storage ring. Although this instability might pose a challenge for future intensity upgrades, its nature had not been completely understood. The phenomena has been studied experimentally by comparing the dynamics of stable and unstable beam, numerically by simulating the build-up of the electron cloud and its interaction with the beam, and analytically by constructing a model of an electron cloud driven instability with the electrons trapped in combined function dipoles. Stabilization of the beam by a clearing bunch reveals that the instability is caused by the electron cloud, trapped in beam optics magnets. Measurements of microwave propagation confirm the presence of the cloud in the combined function dipoles. Numerical simulations show that up to 10$^{-2}$ of the particles can be trapped by their magnetic field. Since the process of electron cloud build-up is exponential, once trapped this amount of electrons significantly increases the density of the cloud on the next revolution. In a combined function dipole this multi-turn accumulation allows the electron cloud reaching final intensities orders of magnitude greater than in a pure dipole. The estimated fast instability growth rate of about 30 revolutions and low mode frequency of 0.4 MHz are consistent with experimental observations and agree with the simulations. The created instability model allows investigating the beam stability for the future intensity upgrades.

  8. The combined effects of e-beam irradiation and microwaves on starch, flour and ingredients

    International Nuclear Information System (INIS)

    Ferdes, O.S.; Martin, D.; Minea, R.; Tirlea, A.; Badea, M.

    1998-01-01

    The influences of both microwave field and electron beam irradiation, separately and combined, mainly on physical parameters of corn starch, wheat flour and black pepper were studied. These treatments have been used to achieve the hygienic and microbiological quality requirements of these materials and for their dehydration. The electron-beam irradiation has been carried out by using an ALIN-7 linear accelerator with the following parameters: electron mean energy 6 MeV, mean bean current 10 μA, pulse period 3.5 μs. repetition frequency 100 Hz. For microwave experiments, a special designed microwave applicator consisting of a special cavity, a power controlled generator with a 2.45 GHz standard frequency CW magnetron of 850 W maximum output power was used. The experiments were carried out in 5 variants: microwave treatment solely; electron beam irradiation solely; microwave treatment followed by electron beam irradiation; electron beam irradiation followed by microwave treatment; simultaneous microwave and electron beam treatment. The samples were treated by microwaves at 4 different power values from 250 W to 550 W for 5 different exposure times. The electron beam irradiation took place within the dose range of 1 - 10 kGy, at the same dose rate of approximately 2 kGy/min. The influence of these two physical fields on some common properties (r.h., pH), spectrophotometric (UV-VIS spectra), viscometric (rheograms) and microbiological (CFU/g) properties of the food materials was evaluated. A direct relationship between the variables was observed. The microwave effects are mainly thermal effects, although a non-thermal effect was also observed. The main microbiocidal action is due to the electron beam effect, although the microwave treatment affects sometimes significantly both the microbial population and its sensitivity to irradiation. The combined treatment indicates the presence of a synergistic effect of microwaves and electron-beams, which is of non

  9. Application of electron-beam irradiation combined with antioxidants for fermented sausage and its quality characteristic

    Science.gov (United States)

    Lim, D. G.; Seol, K. H.; Jeon, H. J.; Jo, C.; Lee, M.

    2008-06-01

    The effects of various doses of electron-beam irradiation on the changes in microbiological attributes of fermented sausage and the combined effect of electron-beam irradiation and various antioxidants on the oxidative stability and sensory properties during cold storage were investigated. Results indicated that 2 kGy of irradiation was the most effective in manufacturing a fermented sausage, and the addition of rosemary extracts was effective in controlling the production of off-flavor and development of lipid oxidation during cold storage.

  10. Combining active chilled beams and air cleaning technologies to improve indoor climate in offices

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Afshari, Alireza; Bergsøe, Niels Christian

    2012-01-01

    This project is part of a long-term research programme studying the possibilities of using efficient air cleaning technologies to improve the indoor air quality in buildings. The purpose of this part of the project is to study energy-saving potential by combining cooling and cleaning of air in of....... Furthermore, the measurement results of the combined system showed that adding the filter accelerated the removal rate of the particles by 2 (h-1). However, the efficiency of the chilled beam in exchanging the heat reduced by 38%....... in offices. For this purpose, a mechanical filter with low pressure drop was selected to be tested in a laboratory environment. The measurements included tests of the filter in a ductwork to study the efficiency of the filter. Moreover, the combined system of the filter and a chilled beam was tested...

  11. Combining active chilled beams and air-cleaning technologies to improve the indoor climate in offices

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Afshari, Alireza; Bergsøe, Niels Christian

    2013-01-01

    This project is part of a long-term research programme to study the possibilities of using efficient air-cleaning technologies to improve the indoor air quality in buildings. The purpose of this part of the project was to study the energy-saving potential of combining the cooling and cleaning of ...... than 5 Pa (0.104 Ibf /ft2). Furthermore, the measurement results of the combined system showed that adding the filter accelerated the removal rate of the particles by 2 h-1. However, the efficiency of the chilled beam in exchanging heat was reduced by 38%....... of air in offices. For this purpose, a mechanical filter with low pressure drop was selected for testing in a laboratory environment. The measurements included tests of the filter in a ductwork to study the efficiency of the filter. Moreover, the combined system of the filter and a chilled beam...

  12. Adaptive Beamformer Combined with Phase Coherence Weighting Applied to Ultrafast Ultrasound

    Directory of Open Access Journals (Sweden)

    Michiya Mozumi

    2018-01-01

    Full Text Available Ultrafast ultrasound imaging is a promising technique for measurement of fast moving objects. In ultrafast ultrasound imaging, the high temporal resolution is realized at the expense of the lateral spatial resolution and image contrast. The lateral resolution and image contrast are important factors determining the quality of a B-mode image, and methods for improvements of the lateral resolution and contrast have been developed. In the present study, we focused on two signal processing techniques; one is an adaptive beamformer, and the other is the phase coherence factor (PCF. By weighting the output of the modified amplitude and phase estimation (mAPES beamformer by the phase coherence factor, image quality was expected to be improved. In the present study, we investigated how to implement the PCF into the mAPES beamformer. In one of the two examined strategies, the PCF is estimated using element echo signals before application of the weight vector determined by the adaptive beamformer. In the other strategy, the PCF was evaluated from the element signals subjected to the mAPES beamformer weights. The performance of the proposed method was evaluated by the experiments using an ultrasonic imaging phantom. Using the proposed strategies, the lateral full widths at half maximum (FWHM were both 0.288 mm, which was better than that of 0.348 mm obtained by the mAPES beamformer only. Also, the image contrasts realized by the mAPES beamformer with the PCFs estimated before and after application of the mAPES beamformer weights to the element signals were 5.61 dB and 5.32 dB, respectively, which were better than that of 5.14 dB obtained by the mAPES beamformer only.

  13. Coherent x-rays from PEP

    International Nuclear Information System (INIS)

    Baird, S.; Nuhn, H.-D.; Tatchyn, R.; Winick, H.; Fisher, A.S.; Gallardo, J.C.; Pellegrini, C.

    1991-01-01

    This paper explores the use of a large-circumference, high-energy, electron-positron collider such as PEP to drive a free-electron laser (FEL), producing high levels of coherent power at short wavelengths. The author consider Self-Amplified Spontaneous Emission (SASE), in which electron bunches with low emittance, high peak current and small energy spread radiate coherently in a single passthrough a long undulator. As the electron beam passes down the undulator, its interaction with the increasingly intense spontaneous radiation causes a bunch density modulation at the optical wavelength, resulting in stimulated emissional growth of coherent power in a single pass. The need for optical-cavity mirrors, which place a lower limit on the wavelength of a conventional FEL oscillator, is avoided. The authors explore various combinations of electron-beam and undulator parameters, as well as special undulator designs and optical klystrons (OK), to reach high average or peak coherent power at wavelengths around 40 angstrom by achieving significant exponential gain or full saturation. Examples are presented for devices that achieve high peak coherent power (up to about 400 MW) with lower average coherent power (about 20 mW) and other devices which produce a few watts of average coherent power

  14. Alignment of the Pixel and SCT Modules for the 2004 ATLAS Combined Test Beam

    Energy Technology Data Exchange (ETDEWEB)

    ATLAS Collaboration; Ahmad, A.; Andreazza, A.; Atkinson, T.; Baines, J.; Barr, A.J.; Beccherle, R.; Bell, P.J.; Bernabeu, J.; Broklova, Z.; Bruckman de Renstrom, P.A.; Cauz, D.; Chevalier, L.; Chouridou, S.; Citterio, M.; Clark, A.; Cobal, M.; Cornelissen, T.; Correard, S.; Costa, M.J.; Costanzo, D.; Cuneo, S.; Dameri, M.; Darbo, G.; de Vivie, J.B.; Di Girolamo, B.; Dobos, D.; Drasal, Z.; Drohan, J.; Einsweiler, K.; Elsing, M.; Emelyanov, D.; Escobar, C.; Facius, K.; Ferrari, P.; Fergusson, D.; Ferrere, D.; Flick,, T.; Froidevaux, D.; Gagliardi, G.; Gallas, M.; Gallop, B.J.; Gan, K.K.; Garcia, C.; Gavrilenko, I.L.; Gemme, C.; Gerlach, P.; Golling, T.; Gonzalez-Sevilla, S.; Goodrick, M.J.; Gorfine, G.; Gottfert, T.; Grosse-Knetter, J.; Hansen, P.H.; Hara, K.; Hartel, R.; Harvey, A.; Hawkings, R.J.; Heinemann, F.E.W.; Henss, T.; Hill, J.C.; Huegging, F.; Jansen, E.; Joseph, J.; Unel, M. Karagoz; Kataoka, M.; Kersten, S.; Khomich, A.; Klingenberg, R.; Kodys, P.; Koffas, T.; Konstantinidis, N.; Kostyukhin, V.; Lacasta, C.; Lari, T.; Latorre, S.; Lester, C.G.; Liebig, W.; Lipniacka, A.; Lourerio, K.F.; Mangin-Brinet, M.; Marti i Garcia, S.; Mathes, M.; Meroni, C.; Mikulec, B.; Mindur, B.; Moed, S.; Moorhead, G.; Morettini, P.; Moyse, E.W.J.; Nakamura, K.; Nechaeva, P.; Nikolaev, K.; Parodi, F.; Parzhitskiy, S.; Pater, J.; Petti, R.; Phillips, P.W.; Pinto, B.; Poppleton, A.; Reeves, K.; Reisinger, I.; Reznicek, P.; Risso, P.; Robinson, D.; Roe, S.; Rozanov, A.; Salzburger, A.; Sandaker, H.; Santi, L.; Schiavi, C.; Schieck, J.; Schultes, J.; Sfyrla, A.; Shaw, C.; Tegenfeldt, F.; Timmermans, C.J.W.P.; Toczek, B.; Troncon, C.; Tyndel, M.; Vernocchi, F.; Virzi, J.; Anh, T. Vu; Warren, M.; Weber, J.; Weber, M.; Weidberg, A.R.; Weingarten, J.; Wellsf, P.S.; Zhelezkow, A.

    2008-06-02

    A small set of final prototypes of the ATLAS Inner Detector silicon tracking system(Pixel Detector and SemiConductor Tracker), were used to take data during the 2004 Combined Test Beam. Data were collected from runs with beams of different flavour (electrons, pions, muons and photons) with a momentum range of 2 to 180 GeV/c. Four independent methods were used to align the silicon modules. The corrections obtained were validated using the known momenta of the beam particles and were shown to yield consistent results among the different alignment approaches. From the residual distributions, it is concluded that the precision attained in the alignmentof the silicon modules is of the order of 5 mm in their most precise coordinate.

  15. A layer correlation technique for pion energy calibration at the 2004 ATLAS Combined Beam Test

    Science.gov (United States)

    Abat, E.; Abdallah, J. M.; Addy, T. N.; Adragna, P.; Aharrouche, M.; Ahmad, A.; Akesson, T. P. A.; Aleksa, M.; Alexa, C.; Anderson, K.; Andreazza, A.; Anghinolfi, F.; Antonaki, A.; Arabidze, G.; Arik, E.; Atkinson, T.; Baines, J.; Baker, O. K.; Banfi, D.; Baron, S.; Barr, A. J.; Beccherle, R.; Beck, H. P.; Belhorma, B.; Bell, P. J.; Benchekroun, D.; Benjamin, D. P.; Benslama, K.; Bergeaas Kuutmann, E.; Bernabeu, J.; Bertelsen, H.; Binet, S.; Biscarat, C.; Boldea, V.; Bondarenko, V. G.; Boonekamp, M.; Bosman, M.; Bourdarios, C.; Broklova, Z.; Burckhart Chromek, D.; Bychkov, V.; Callahan, J.; Calvet, D.; Canneri, M.; Capeáns Garrido, M.; Caprini, M.; Cardiel Sas, L.; Carli, T.; Carminati, L.; Carvalho, J.; Cascella, M.; Castillo, M. V.; Catinaccio, A.; Cauz, D.; Cavalli, D.; Cavalli Sforza, M.; Cavasinni, V.; Cetin, S. A.; Chen, H.; Cherkaoui, R.; Chevalier, L.; Chevallier, F.; Chouridou, S.; Ciobotaru, M.; Citterio, M.; Clark, A.; Cleland, B.; Cobal, M.; Cogneras, E.; Conde Muino, P.; Consonni, M.; Constantinescu, S.; Cornelissen, T.; Correard, S.; Corso Radu, A.; Costa, G.; Costa, M. J.; Costanzo, D.; Cuneo, S.; Cwetanski, P.; Da Silva, D.; Dam, M.; Dameri, M.; Danielsson, H. O.; Dannheim, D.; Darbo, G.; Davidek, T.; De, K.; Defay, P. O.; Dekhissi, B.; Del Peso, J.; Del Prete, T.; Delmastro, M.; Derue, F.; Di Ciaccio, L.; Di Girolamo, B.; Dita, S.; Dittus, F.; Djama, F.; Djobava, T.; Dobos, D.; Dobson, M.; Dolgoshein, B. A.; Dotti, A.; Drake, G.; Drasal, Z.; Dressnandt, N.; Driouchi, C.; Drohan, J.; Ebenstein, W. L.; Eerola, P.; Efthymiopoulos, I.; Egorov, K.; Eifert, T. F.; Einsweiler, K.; El Kacimi, M.; Elsing, M.; Emelyanov, D.; Escobar, C.; Etienvre, A. I.; Fabich, A.; Facius, K.; Fakhr-Edine, A. I.; Fanti, M.; Farbin, A.; Farthouat, P.; Fassouliotis, D.; Fayard, L.; Febbraro, R.; Fedin, O. L.; Fenyuk, A.; Fergusson, D.; Ferrari, P.; Ferrari, R.; Ferreira, B. C.; Ferrer, A.; Ferrere, D.; Filippini, G.; Flick, T.; Fournier, D.; Francavilla, P.; Francis, D.; Froeschl, R.; Froidevaux, D.; Fullana, E.; Gadomski, S.; Gagliardi, G.; Gagnon, P.; Gallas, M.; Gallop, B. J.; Gameiro, S.; Gan, K. K.; Garcia, R.; Garcia, C.; Gavrilenko, I. L.; Gemme, C.; Gerlach, P.; Ghodbane, N.; Giakoumopoulou, V.; Giangiobbe, V.; Giokaris, N.; Glonti, G.; Goettfert, T.; Golling, T.; Gollub, N.; Gomes, A.; Gomez, M. D.; Gonzalez-Sevilla, S.; Goodrick, M. J.; Gorfine, G.; Gorini, B.; Goujdami, D.; Grahn, K.-J.; Grenier, P.; Grigalashvili, N.; Grishkevich, Y.; Grosse-Knetter, J.; Gruwe, M.; Guicheney, C.; Gupta, A.; Haeberli, C.; Haertel, R.; Hajduk, Z.; Hakobyan, H.; Hance, M.; Hansen, J. D.; Hansen, P. H.; Hara, K.; Harvey, A., Jr.; Hawkings, R. J.; Heinemann, F. E. W.; Henriques Correia, A.; Henss, T.; Hervas, L.; Higon, E.; Hill, J. C.; Hoffman, J.; Hostachy, J. Y.; Hruska, I.; Hubaut, F.; Huegging, F.; Hulsbergen, W.; Hurwitz, M.; Iconomidou-Fayard, L.; Jansen, E.; Jen-La Plante, I.; Johansson, P. D. C.; Jon-And, K.; Joos, M.; Jorgensen, S.; Joseph, J.; Kaczmarska, A.; Kado, M.; Karyukhin, A.; Kataoka, M.; Kayumov, F.; Kazarov, A.; Keener, P. T.; Kekelidze, G. D.; Kerschen, N.; Kersten, S.; Khomich, A.; Khoriauli, G.; Khramov, E.; Khristachev, A.; Khubua, J.; Kittelmann, T. H.; Klingenberg, R.; Klinkby, E. B.; Kodys, P.; Koffas, T.; Kolos, S.; Konovalov, S. P.; Konstantinidis, N.; Kopikov, S.; Korolkov, I.; Kostyukhin, V.; Kovalenko, S.; Kowalski, T. Z.; Krüger, K.; Kramarenko, V.; Kudin, L. G.; Kulchitsky, Y.; Lacasta, C.; Lafaye, R.; Laforge, B.; Lampl, W.; Lanni, F.; Laplace, S.; Lari, T.; Le Bihan, A.-C.; Lechowski, M.; Ledroit-Guillon, F.; Lehmann, G.; Leitner, R.; Lelas, D.; Lester, C. G.; Liang, Z.; Lichard, P.; Liebig, W.; Lipniacka, A.; Lokajicek, M.; Louchard, L.; Lourerio, K. F.; Lucotte, A.; Luehring, F.; Lund-Jensen, B.; Lundberg, B.; Ma, H.; Mackeprang, R.; Maio, A.; Maleev, V. P.; Malek, F.; Mandelli, L.; Maneira, J.; Mangin-Brinet, M.; Manousakis, A.; Mapelli, L.; Marques, C.; Garcia, S. Marti i.; Martin, F.; Mathes, M.; Mazzanti, M.; McFarlane, K. W.; McPherson, R.; Mchedlidze, G.; Mehlhase, S.; Meirosu, C.; Meng, Z.; Meroni, C.; Mialkovski, V.; Mikulec, B.; Milstead, D.; Minashvili, I.; Mindur, B.; Mitsou, V. A.; Moed, S.; Monnier, E.; Moorhead, G.; Morettini, P.; Morozov, S. V.; Mosidze, M.; Mouraviev, S. V.; Moyse, E. W. J.; Munar, A.; Myagkov, A.; Nadtochi, A. V.; Nakamura, K.; Nechaeva, P.; Negri, A.; Nemecek, S.; Nessi, M.; Nesterov, S. Y.; Newcomer, F. M.; Nikitine, I.; Nikolaev, K.; Nikolic-Audit, I.; Ogren, H.; Oh, S. H.; Oleshko, S. B.; Olszowska, J.; Onofre, A.; Padilla Aranda, C.; Paganis, S.; Pallin, D.; Pantea, D.; Paolone, V.; Parodi, F.; Parsons, J.; Parzhitskiy, S.; Pasqualucci, E.; Passmored, S. M.; Pater, J.; Patrichev, S.; Peez, M.; Perez Reale, V.; Perini, L.; Peshekhonov, V. D.; Petersen, J.; Petersen, T. C.; Petti, R.; Phillips, P. W.; Pina, J.; Pinto, B.; Podlyski, F.; Poggioli, L.; Poppleton, A.; Poveda, J.; Pralavorio, P.; Pribyl, L.; Price, M. J.; Prieur, D.; Puigdengoles, C.; Puzo, P.; RØhne, O.; Ragusa, F.; Rajagopalan, S.; Reeves, K.; Reisinger, I.; Rembser, C.; Bruckman de Renstrom, P. A.; Reznicek, P.; Ridel, M.; Risso, P.; Riu, I.; Robinson, D.; Roda, C.; Roe, S.; Rohne, O.; Romaniouk, A.; Rousseau, D.; Rozanov, A.; Ruiz, A.; Rusakovich, N.; Rust, D.; Ryabov, Y. F.; Ryjov, V.; Salto, O.; Salvachua, B.; Salzburger, A.; Sandaker, H.; Santamarina Rios, C.; Santi, L.; Santoni, C.; Saraiva, J. G.; Sarri, F.; Sauvage, G.; Says, L. P.; Schaefer, M.; Schegelsky, V. A.; Schiavi, C.; Schieck, J.; Schlager, G.; Schlereth, J.; Schmitt, C.; Schultes, J.; Schwemling, P.; Schwindling, J.; Seixas, J. M.; Seliverstov, D. M.; Serin, L.; Sfyrla, A.; Shalanda, N.; Shaw, C.; Shin, T.; Shmeleva, A.; Silva, J.; Simion, S.; Simonyan, M.; Sloper, J. E.; Smirnov, S. Yu; Smirnova, L.; Solans, C.; Solodkov, A.; Solovianov, O.; Soloviev, I.; Sosnovtsev, V. V.; Spanò, F.; Speckmayer, P.; Stancu, S.; Stanek, R.; Starchenko, E.; Straessner, A.; Suchkov, S. I.; Suk, M.; Szczygiel, R.; Tarrade, F.; Tartarelli, F.; Tas, P.; Tayalati, Y.; Tegenfeldt, F.; Teuscher, R.; Thioye, M.; Tikhomirov, V. O.; Timmermans, C. J. W. P.; Tisserant, S.; Toczek, B.; Tremblet, L.; Troncon, C.; Tsiareshka, P.; Tyndel, M.; Karagoez Unel, M.; Unal, G.; Unel, G.; Usai, G.; Van Berg, R.; Valero, A.; Valkar, S.; Valls, J. A.; Vandelli, W.; Vannucci, F.; Vartapetian, A.; Vassilakopoulos, V. I.; Vasilyeva, L.; Vazeille, F.; Vernocchi, F.; Vetter-Cole, Y.; Vichou, I.; Vinogradov, V.; Virzi, J.; Vivarelli, I.; de Vivie, J. B.; Volpi, M.; Anh, T. Vu; Wang, C.; Warren, M.; Weber, J.; Weber, M.; Weidberg, A. R.; Weingarten, J.; Wells, P. S.; Werner, P.; Wheeler, S.; Wiessmann, M.; Wilkens, H.; Williams, H. H.; Wingerter-Seez, I.; Yasu, Y.; Zaitsev, A.; Zenin, A.; Zenis, T.; Zenonos, Z.; Zhang, H.; Zhelezko, A.; Zhou, N.

    2011-06-01

    A new method for calibrating the hadron response of a segmented calorimeter is developed and successfully applied to beam test data. It is based on a principal component analysis of energy deposits in the calorimeter layers, exploiting longitudinal shower development information to improve the measured energy resolution. Corrections for invisible hadronic energy and energy lost in dead material in front of and between the calorimeters of the ATLAS experiment were calculated with simulated Geant4 Monte Carlo events and used to reconstruct the energy of pions impinging on the calorimeters during the 2004 Barrel Combined Beam Test at the CERN H8 area. For pion beams with energies between 20GeV and 180GeV, the particle energy is reconstructed within 3% and the energy resolution is improved by between 11% and 25% compared to the resolution at the electromagnetic scale.

  16. Flat profile laser beam shaper

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Todd R.

    2017-09-12

    A system for shaping a beam comprises an emitter for emitting coherent electromagnetic radiation. Birefringent displacers are configured between the emitter and a target wherein the at least two birefringent displacers split the coherent electromagnetic radiation into a plurality of coherent parallel beams of electromagnetic radiation thereby producing a shaped wave front of the coherent parallel beams of electromagnetic radiation.

  17. LISE 3: a magnetic spectrometer-Wien filter combination for secondary radioactive beam production

    Energy Technology Data Exchange (ETDEWEB)

    Anne, R. (GANIL, 14 - Caen (France)); Mueller, A.C. (IPN, 91 - Orsay (France))

    1992-08-01

    The double achromatic spectrometer LISE installed at GANIL has been running since six years for the study of exotic nuclei and the production of secondary beams obtained by the interaction of high energy heavy ions (E/A < 100 MeV) with thick targets (up to 1 g/cm[sup 2]). Essentially it is composed of two dipole magnets selecting the nuclear reaction products according to A/Z at 0[sup 0]. Combined with an achromatic degrader located in the intermediate focal plane, it provides a selection in A[sup 3]/Z[sup 2]. Recently we have upgraded LISE by two major improvements. i) The angle of entry of the primary beam with respect to the axis of the spectrometer has been made variable (0[sup 0] to 3.5[sup 0]). This allows the suppression of remaining incomplete stripped beam-charge-states in experiments with heavy beams (Z > 30). ii) A velocity filter based on an electrostatic field crossed with a magnetic one has been installed. This filter provides a third selection which is powerful in suppressing contaminants. Furthermore, the flight path between the target and the final focus is now increased to 43 m, which allows easy time-of-flight measurements also for heavy species. LISE 3 provides separated secondary beams of increased intensity and isotopic purity. We shall review the essential properties and present some recent experiment results for illustration. (orig.).

  18. Combination photo and electron beam lithography with polymethyl methacrylate (PMMA) resist

    Science.gov (United States)

    Carbaugh, Daniel J.; Pandya, Sneha G.; Wright, Jason T.; Kaya, Savas; Rahman, Faiz

    2017-11-01

    We describe techniques for performing photolithography and electron beam lithography in succession on the same resist-covered substrate. Larger openings are defined in the resist film through photolithography whereas smaller openings are defined through conventional electron beam lithography. The two processes are carried out one after the other and without an intermediate wet development step. At the conclusion of the two exposures, the resist film is developed once to reveal both large and small openings. Interestingly, these techniques are applicable to both positive and negative tone lithographies with both optical and electron beam exposure. Polymethyl methacrylate, by itself or mixed with a photocatalytic cross-linking agent, is used for this purpose. We demonstrate that such resists are sensitive to both ultraviolet and electron beam irradiation. All four possible combinations, consisting of optical and electron beam lithographies, carried out in positive and negative tone modes have been described. Demonstration grating structures have been shown and process conditions have been described for all four cases.

  19. Analyzing the propagation behavior of scintillation index and bit error rate of a partially coherent flat-topped laser beam in oceanic turbulence.

    Science.gov (United States)

    Yousefi, Masoud; Golmohammady, Shole; Mashal, Ahmad; Kashani, Fatemeh Dabbagh

    2015-11-01

    In this paper, on the basis of the extended Huygens-Fresnel principle, a semianalytical expression for describing on-axis scintillation index of a partially coherent flat-topped (PCFT) laser beam of weak to moderate oceanic turbulence is derived; consequently, by using the log-normal intensity probability density function, the bit error rate (BER) is evaluated. The effects of source factors (such as wavelength, order of flatness, and beam width) and turbulent ocean parameters (such as Kolmogorov microscale, relative strengths of temperature and salinity fluctuations, rate of dissipation of the mean squared temperature, and rate of dissipation of the turbulent kinetic energy per unit mass of fluid) on propagation behavior of scintillation index, and, hence, on BER, are studied in detail. Results indicate that, in comparison with a Gaussian beam, a PCFT laser beam with a higher order of flatness is found to have lower scintillations. In addition, the scintillation index and BER are most affected when salinity fluctuations in the ocean dominate temperature fluctuations.

  20. csiLSFM combines light-sheet fluorescence microscopy and coherent structured illumination for a lateral resolution below 100 nm.

    Science.gov (United States)

    Chang, Bo-Jui; Perez Meza, Victor Didier; Stelzer, Ernst H K

    2017-05-09

    Light-sheet-based fluorescence microscopy (LSFM) features optical sectioning in the excitation process. It minimizes fluorophore bleaching as well as phototoxic effects and provides a true axial resolution. The detection path resembles properties of conventional fluorescence microscopy. Structured illumination microscopy (SIM) is attractive for superresolution because of its moderate excitation intensity, high acquisition speed, and compatibility with all fluorophores. We introduce SIM to LSFM because the combination pushes the lateral resolution to the physical limit of linear SIM. The instrument requires three objective lenses and relies on methods to control two counterpropagating coherent light sheets that generate excitation patterns in the focal plane of the detection lens. SIM patterns with the finest line spacing in the far field become available along multiple orientations. Flexible control of rotation, frequency, and phase shift of the perfectly modulated light sheet are demonstrated. Images of beads prove a near-isotropic lateral resolution of sub-100 nm. Images of yeast endoplasmic reticulum show that coherent structured illumination (csi) LSFM performs with physiologically relevant specimens.

  1. Research progress in plant mutation by combining ion beam irradiations and tissue culture

    International Nuclear Information System (INIS)

    Zhou Linbin; Li Wenjian; Qu Ying; Li Ping

    2007-01-01

    About a new mutation breeding method which combines plant tissue culture technique with heavy ion beam irradiations were discussed in this paper with the principles, operation steps, molecular mechanisms, etc. The mutation method developed a few advantages coming from plant tissue culture, which can produce offspring by asexual ways. Meanwhile, using this method, the study of biological effects of high energy particles with different linear energy transfer values on plant tissues or cells can be explored and optimized in theory or practice. (authors)

  2. Combined centroid-envelope dynamics of intense, magnetically focused charged beams surrounded by conducting walls

    International Nuclear Information System (INIS)

    Fiuza, K.; Rizzato, F.B.; Pakter, R.

    2006-01-01

    In this paper we analyze the combined envelope-centroid dynamics of magnetically focused high-intensity charged beams surrounded by conducting walls. Similar to the case where conducting walls are absent, it is shown that the envelope and centroid dynamics decouple from each other. Mismatched envelopes still decay into equilibrium with simultaneous emittance growth, but the centroid keeps oscillating with no appreciable energy loss. Some estimates are performed to analytically obtain characteristics of halo formation seen in the full simulations

  3. A non-destructive electron beam diagnostic for a SASE FEL using coherent off-axis undulator radiation

    International Nuclear Information System (INIS)

    Neuman, C.P.; Ponds, M.L.; Barnett, G.A.; Madey, J.M.J.; O'Shea, P.G.

    1999-01-01

    We show that by observing coherent off-axis undulator radiation (COUR) from a short diagnostic wiggler, it may be possible to determine the length and structure of a short electron bunch. Typically the on-axis undulator radiation is incoherent, but at angles of a few degrees, the wavelength of the emitted radiation may be comparable to the length of a short electron bunch, and thus coherence effects emerge. Due to such coherence effects, the intensity of the emitted radiation may change by up to a factor of 10 9 as the angle of observation is increased. The radiation becomes coherent in a way which depends on the length and structure of the electron bunch. Observing COUR disturbs the electron bunch negligibly. Thus, COUR can be used as a non-destructive diagnostic which would allow for optimization of FEL performance while an FEL is operating. Such a diagnostic could be used for proposed SASE FELs, which use short electron bunches. We present two methods to describe the theory for COUR, and we use these methods to calculate the expected outcome of a COUR experiment. We propose an experiment to demonstrate COUR effects and their applications to SASE FELs

  4. Quasi-optical coherence vibration tomography technique for damage detection in beam-like structures based on auxiliary mass induced frequency shift

    Science.gov (United States)

    Zhong, Shuncong; Zhong, Jianfeng; Zhang, Qiukun; Maia, Nuno

    2017-09-01

    A novel quasi-optical coherence vibration tomography (Quasi-OCVT) measurement system suitable for structural damage detection is proposed by taking the concept of two-dimensional optical coherence vibration tomography (2D-OCVT) technique. An artificial quasi-interferogram fringe pattern (QIFP) similar to the interferogram of 2D-OCVT system, as a sensor, was pasted on the surface of a vibrating structure. Image sequences of QIFP were captured by a high-speed camera that worked as a detector. The period density of the imaged QIFP changed due to the structural vibration, from which the vibration information of the structure could be obtained. Noise influence on the measurement accuracy, torsional sensitivity and optical distortion effect of the Quasi-OCVT system were investigated. The efficiency and reliability of the proposed method were demonstrated by applying the system to damage detection of a cracked beam-like structure with a roving auxiliary mass. The roving of the mass along the cracked beam brings about the change of natural frequencies that could be obtained by the Quasi-OCVT technique. Therefore, frequency-shift curves can be achieved and these curves provide additional spatial information for structural damage detection. Same cases were also analyzed by the finite element method (FEM) and conventional accelerometer-based measurement method. Comparisons were carried out among these results. Results obtained by the proposed Quasi-OCVT method had a good agreement with the ones obtained by FEM, from which the damage could be directly detected. However, the results obtained by conventional accelerometer showed misleading ambiguous peaks at damage position owing to the mass effect on the structure, where the damage location cannot be identified confidently without further confirmation. The good performance of the cost-effective Quasi-OCVT method makes it attractive for vibration measurement and damage detection of beam-like structures.

  5. Direct UV-Written Integrated Optical Beam Combiner for Stellar Interferometry

    DEFF Research Database (Denmark)

    Olivero, Massimo; Svalgaard, Mikael; Jocou, L.

    2007-01-01

    In this paper, we report the fabrication of an optical-beam combiner for stellar interferometry by means of direct ultraviolet (UV) writing. The component is shown to have good performance (fringe contrast > 95%, total loss similar to 0.7, -40-dB crosstalk, broadband operation covering at least...... the range 1.49-1.65 mu m, and low differential chromatic dispersion). The overall performance exceeds that of similar components currently used for astronomical research. This result, combined with the fast-prototyping ability of UV writing, opens up new possibilities for the realization of highly optimized...

  6. Superconducting toroidal combined-function magnet for a compact ion beam cancer therapy gantry

    International Nuclear Information System (INIS)

    Robin, D.S.; Arbelaez, D.; Caspi, S.; Sun, C.; Sessler, A.; Wan, W.; Yoon, M.

    2011-01-01

    A superconducting, combined-function, 5 T, 90°, toroidal magnet with a large bore is described in this paper. This magnet is designed to be the last and most difficult part of a compact superconducting magnet-based carbon gantry optics for ion beam cancer therapy. The relatively small size of this toroidal magnet allows for a gantry the size of which is smaller or at least comparable to that of a proton gantry. The gantry design places the toroidal magnet between the scanning magnets and the patient, that is the scanning magnets are placed midway through the gantry. By optimizing the coil winding configuration of this magnet, near point-to-parallel optics is achieved between the scanning magnets and the patient; while at the same time there is only a small distortion of the beam-shape when scanning. We show that the origin of the beam-shape distortion is the strong sextupole components, whose effects are greatly pronounced when the beam is widely steered in the magnet. A method to correct such an undesirable effect is suggested and demonstrated by a numerical particle tracking through the calculated three-dimensional magnetic field.

  7. Near-diffraction-limited segmented broad area diode laser based on off-axis spectral beam combining

    DEFF Research Database (Denmark)

    Jensen, O.B.; Thestrup Nielsen, Birgitte; Andersen, Peter E.

    2006-01-01

    The beam quality of a 500-mu m-wide broad area diode laser with five active segments has been improved beyond the beam quality of the individual segments. The principle of this new laser system is based on off-axis feedback in combination with spectral beam combining. By using a double......-feedback scheme we are able to improve the beam quality of the laser by a factor of 23 from M-2 = 55 for the free-running diode laser to M-2 = 2.4 for the laser with feedback at a drive current of 2.2 A. The improved M-2 value is a factor of 3.4 below M-2 = 8.2 for a single free-running segment. This is the first...... time that the beam quality of a segmented broad area diode laser has been improved beyond the beam quality of the individual segments....

  8. Monte Carlo studies of the radiation fields in the linac coherent light source undulators and of the corresponding signals in the Cerenkov beam loss monitors

    International Nuclear Information System (INIS)

    Santana Leitner, Mario; Fasso, Alberto; Fisher, Alan S.; Nuhn, Heinz D.; Dooling, Jeffrey C.; Berg, William; Yang, Bin. X.

    2010-01-01

    In 2009 the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Center started free electron laser (FEL) operation. In order to continue to produce the bright and short-pulsed x-ray laser demanded by FEL scientists, this pioneer hard x-ray FEL requires a perfectly tailored magnetic field at the undulators, so that the photons generated at the electron wiggling path interact at the right phase with the electron beam. In such a precise system, small (>0.01%) radiation-induced alterations of the magnetic field in the permanent magnets could affect FEL performance. This paper describes the simulation studies of radiation fields in permanent magnets and the expected signal in the detectors. The transport of particles from the radiation sources (i.e. diagnostic insert) to the undulator magnets and to the beam loss monitors (BLM) was simulated with the intra nuclear cascade codes FLUKA and MARS15. In order to accurately reproduce the optics of LCLS, lattice capabilities and magnetic fields were enabled in FLUKA and betatron oscillations were validated against reference data. All electron events entering the BLMs were printed in data files. The paper also introduces the Radioactive Ion Beam Optimizer (RIBO) Monte Carlo 3-D code, which was used to read from the event files, to compute Cerenkov production and then to simulate the optical coupling of the BLM detectors, accounting for the transmission of light through the quartz. (author)

  9. Spatial coherence of electron beams from field emitters and its effect on the resolution of imaged objects

    Energy Technology Data Exchange (ETDEWEB)

    Latychevskaia, Tatiana, E-mail: tatiana@physik.uzh.ch

    2017-04-15

    Sub-nanometer and nanometer-sized tips provide high coherence electron sources. Conventionally, the effective source size is estimated from the extent of the experimental biprism interference pattern created on the detector by applying the van Cittert Zernike theorem. Previously reported experimental intensity distributions on the detector exhibit Gaussian distribution and our simulations show that this is an indication that such electron sources must be at least partially coherent. This, in turn means that strictly speaking the Van Cittert Zernike theorem cannot be applied, since it assumes an incoherent source. The approach of applying the van Cittert Zernike theorem is examined in more detail by performing simulations of interference patterns for the electron sources of different size and different coherence length, evaluating the effective source size from the extent of the simulated interference pattern and comparing the obtained result with the pre-defined value. The intensity distribution of the source is assumed to be Gaussian distributed, as it is observed in experiments. The visibility or the contrast in the simulated holograms is found to be always less than 1 which agrees well with previously reported experimental results and thus can be explained solely by the Gaussian intensity distribution of the source. The effective source size estimated from the extent of the interference pattern turns out to be of about 2–3 times larger than the pre-defined size, but it is approximately equal to the intrinsic resolution of the imaging system. A simple formula for estimating the intrinsic resolution, which could be useful when employing nano-tips in in-line Gabor holography or point-projection microscopy, is provided. - Highlights: • van Cittert Zernike theorem for nano- and sub-nano electron emitting tips is revised. • Simulations show that nano- and sub-nano electron emitting tips are at least partially coherent. • A simple formula for evaluating

  10. A Layer Correlation Technique for Pion Energy Calibration at the 2004 ATLAS Combined Beam Test

    CERN Document Server

    Grahn, Karl-Johan

    2009-01-01

    A new method for calibrating the hadron response of a segmented calorimeter is developed. It is based on a principal component analysis of the calorimeter layer energy deposits, exploiting longitudinal shower development information to improve the measured energy resolution. Corrections for invisible hadronic energy and energy lost in dead material in front of and between the ATLAS calorimeters were calculated with simulated Geant4 Monte Carlo events and used to reconstruct the energy of pions impinging on the calorimeters during the 2004 Barrel Combined Beam Test at the CERN H8 area. For pion beams with energies between 20 and 180 GeV, the particle energy is reconstructed within 3% and the energy resolution is improved by about 20% compared to the electromagnetic scale.

  11. A Layer Correlation Technique for ATLAS Calorimetry Calibration at the 2004 ATLAS Combined Beam Test

    CERN Document Server

    Carli, T; Spanò, F; Speckmayer, P

    2008-01-01

    A method for calibrating the response of a segmented calorimeter to hadrons is developed. The ansatz is that information on longitudinal shower fluctuations gained from a principal component analysis of the layer energy depositions can improve energy resolution by correcting for hadronic invisible energy and dead material losses: projections along the eigenvectors of the correlation matrix are used as input for the calibration. The technique is used to reconstruct the energy of pions impinging on the ATLAS calorimeters during the 2004 Barrel Combined Beam Test at the CERN H8 area. Simulated Monte Carlo events are used to derive corrections for invisible energy lost in nuclear reactions and in dead material in front and in between the calorimeters. For pion beams with energies between 20 and 180 GeV, the particle energy is reconstructed within 3% and the resolution is improved by about 20%.

  12. Durability of Steel Fibres Reinforcement Concrete Beams in Chloride Environment Combined with Inhibitor

    Directory of Open Access Journals (Sweden)

    AbdelMonem Masmoudi

    2016-01-01

    Full Text Available This paper presented the effect of the combination of an inhibitor and steel fibre reinforced concrete (SFRC for concrete structures in chloride environments. Twelve beams were cast and tested to study their flexural behavior. The morphology of steel surfaces using the inhibitor after observing the scanning electron microscope showed a low layer of corrosion products. The steel surface immersed in the inhibitor free solution was seen to have been subject to chloride ions attacks as shown in this study. The interest to the field of the present study is the relatively higher durability of the performance when using the inhibitor. Crack width and crack spacing for beams under the same load showed that the use of SFRC with the inhibitor for concrete structures in chloride environments must have transferred tension across cracks that led to reducing crack spacing without any chloride ions attack.

  13. Photon reconstruction in the ATLAS inner detector and liquid argon barrel calorimeter at the 2004 combined test beam

    NARCIS (Netherlands)

    Abat, E.; et al., [Unknown; Ferrari, P.; Gorfine, G.; Liebig, W.

    2011-01-01

    The reconstruction of photons in the ATLAS detector is studied with data taken during the 2004 Combined Test Beam, where a full slice of the ATLAS detector was exposed to beams of particles of known energy at the CERN SPS. The results presented show significant differences in the longitudinal

  14. Self-repairing performance of concrete beams strengthened using superelastic SMA wires in combination with adhesives released from hollow fibers

    International Nuclear Information System (INIS)

    Kuang Yachuan; Ou Jinping

    2008-01-01

    By taking advantage of the superelastic effect of shape memory alloy (SMA) and the cohering characteristic of repairing adhesive, a smart self-repairing concrete beam with damage self-repairing performance has been developed. In order to verify the potential self-repairing capacity of smart concrete beams reinforced with SMA wires and brittle fibers containing adhesives, static loading tests were conducted. Experimental results show that the superelastic SMA wires added self-restoration capacity to concrete beams, the deflection of the beams reversed and the crack closed almost completely after unloading. After the release of adhesive from the broken-open fibers into the cracks from the first loading, stress was redistributed to the uncracked section where a new crack was formed, while the sealed crack remained closed during reloading for the smart concrete beams reinforced with SMA wires and brittle fibers containing adhesives. While the original cracks experienced reopening, the load was carried directly by the wires during reloading for concrete beams reinforced with SMA wires

  15. A combination-weighted Feldkamp-based reconstruction algorithm for cone-beam CT

    International Nuclear Information System (INIS)

    Mori, Shinichiro; Endo, Masahiro; Komatsu, Shuhei; Kandatsu, Susumu; Yashiro, Tomoyasu; Baba, Masayuki

    2006-01-01

    The combination-weighted Feldkamp algorithm (CW-FDK) was developed and tested in a phantom in order to reduce cone-beam artefacts and enhance cranio-caudal reconstruction coverage in an attempt to improve image quality when utilizing cone-beam computed tomography (CBCT). Using a 256-slice cone-beam CT (256CBCT), image quality (CT-number uniformity and geometrical accuracy) was quantitatively evaluated in phantom and clinical studies, and the results were compared to those obtained with the original Feldkamp algorithm. A clinical study was done in lung cancer patients under breath holding and free breathing. Image quality for the original Feldkamp algorithm is degraded at the edge of the scan region due to the missing volume, commensurate with the cranio-caudal distance between the reconstruction and central planes. The CW-FDK extended the reconstruction coverage to equal the scan coverage and improved reconstruction accuracy, unaffected by the cranio-caudal distance. The extended reconstruction coverage with good image quality provided by the CW-FDK will be clinically investigated for improving diagnostic and radiotherapy applications. In addition, this algorithm can also be adapted for use in relatively wide cone-angle CBCT such as with a flat-panel detector CBCT

  16. Tests of Local Hadron Calibration approaches in ATLAS Combined Beam Tests

    CERN Document Server

    Pospelov, G; The ATLAS collaboration

    2010-01-01

    The three Atlas calorimeter systems in the region of the forward crack at |eta| = 3.2 in the nominal Atlas setup and a typical section of the two barrel calorimeters at |eta| = 0.45 of Atlas have been exposed to combined beam tests with single electrons and pions. Detailed shower shape studies of electrons and pions with comparisons to various Geant4 based simulations utilizing different physics lists are presented for the endcap testbeam. The local hadronic calibration approach as used in the full Atlas setup has been applied to the endcap test beam data. An extension of it using layer correlations has been tested on the barrel test beam data. Both methods utilize modular correction steps based on shower shape variables to correct for invisible energy inside the reconstructed clusters in the calorimeters (compensation) and for lost energy deposits outside of the reconstructed clusters (dead material and out-of-cluster deposits). Results for both methods and comparisons to MC simulations are presented.

  17. Electromagnetic spatial coherence wavelets

    International Nuclear Information System (INIS)

    Castaneda, R.; Garcia-Sucerquia, J.

    2005-10-01

    The recently introduced concept of spatial coherence wavelets is generalized for describing the propagation of electromagnetic fields in the free space. For this aim, the spatial coherence wavelet tensor is introduced as an elementary amount, in terms of which the formerly known quantities for this domain can be expressed. It allows analyzing the relationship between the spatial coherence properties and the polarization state of the electromagnetic wave. This approach is completely consistent with the recently introduced unified theory of coherence and polarization for random electromagnetic beams, but it provides a further insight about the causal relationship between the polarization states at different planes along the propagation path. (author)

  18. A Comparison of Different Types of Coherent Radiation of a Relativistic Electron-Beam in the X-Ray Range

    NARCIS (Netherlands)

    Tulupov, A. V.

    1993-01-01

    A comparison of the spectral-angular intensity of radiation of a relativistic electron beam is carried oui in the X-ray range for different radiation types: transition radiation: parametric Cherenkov radiation; undulattor radiation: and radiation in the electromagnetic wave field. Simple analytical

  19. A combined approach to cartographic displacement for buildings based on skeleton and improved elastic beam algorithm.

    Directory of Open Access Journals (Sweden)

    Yuangang Liu

    Full Text Available Scale reduction from source to target maps inevitably leads to conflicts of map symbols in cartography and geographic information systems (GIS. Displacement is one of the most important map generalization operators and it can be used to resolve the problems that arise from conflict among two or more map objects. In this paper, we propose a combined approach based on constraint Delaunay triangulation (CDT skeleton and improved elastic beam algorithm for automated building displacement. In this approach, map data sets are first partitioned. Then the displacement operation is conducted in each partition as a cyclic and iterative process of conflict detection and resolution. In the iteration, the skeleton of the gap spaces is extracted using CDT. It then serves as an enhanced data model to detect conflicts and construct the proximity graph. Then, the proximity graph is adjusted using local grouping information. Under the action of forces derived from the detected conflicts, the proximity graph is deformed using the improved elastic beam algorithm. In this way, buildings are displaced to find an optimal compromise between related cartographic constraints. To validate this approach, two topographic map data sets (i.e., urban and suburban areas were tested. The results were reasonable with respect to each constraint when the density of the map was not extremely high. In summary, the improvements include (1 an automated parameter-setting method for elastic beams, (2 explicit enforcement regarding the positional accuracy constraint, added by introducing drag forces, (3 preservation of local building groups through displacement over an adjusted proximity graph, and (4 an iterative strategy that is more likely to resolve the proximity conflicts than the one used in the existing elastic beam algorithm.

  20. A combined approach to cartographic displacement for buildings based on skeleton and improved elastic beam algorithm.

    Science.gov (United States)

    Liu, Yuangang; Guo, Qingsheng; Sun, Yageng; Ma, Xiaoya

    2014-01-01

    Scale reduction from source to target maps inevitably leads to conflicts of map symbols in cartography and geographic information systems (GIS). Displacement is one of the most important map generalization operators and it can be used to resolve the problems that arise from conflict among two or more map objects. In this paper, we propose a combined approach based on constraint Delaunay triangulation (CDT) skeleton and improved elastic beam algorithm for automated building displacement. In this approach, map data sets are first partitioned. Then the displacement operation is conducted in each partition as a cyclic and iterative process of conflict detection and resolution. In the iteration, the skeleton of the gap spaces is extracted using CDT. It then serves as an enhanced data model to detect conflicts and construct the proximity graph. Then, the proximity graph is adjusted using local grouping information. Under the action of forces derived from the detected conflicts, the proximity graph is deformed using the improved elastic beam algorithm. In this way, buildings are displaced to find an optimal compromise between related cartographic constraints. To validate this approach, two topographic map data sets (i.e., urban and suburban areas) were tested. The results were reasonable with respect to each constraint when the density of the map was not extremely high. In summary, the improvements include (1) an automated parameter-setting method for elastic beams, (2) explicit enforcement regarding the positional accuracy constraint, added by introducing drag forces, (3) preservation of local building groups through displacement over an adjusted proximity graph, and (4) an iterative strategy that is more likely to resolve the proximity conflicts than the one used in the existing elastic beam algorithm.

  1. Coherent vertical beaming using Bragg mirrors for high-efficiency GaN light-emitting diodes.

    Science.gov (United States)

    Kim, Sun-Kyung; Park, Hong-Gyu

    2013-06-17

    We propose a dielectric Bragg mirror that utilizes coherent coupling with multiple quantum wells (MQWs) to significantly enhance light extraction from GaN light-emitting diode (LED). Full vectorial electromagnetic simulation showed that, under constructive interference conditions, the Bragg mirror consisting of two dielectric (SiO(2)/TiO(2)) stacks and a silver layer led to >30% enhancement in light extraction, as compared to a single silver mirror. Such significant enhancement by a pre-designed Bragg/metal mirror was ascribed to the vertically oriented radiation pattern and reduced plasmonic metal loss. In addition, the gap distance between the MQWs and a Bragg mirror at which the constructive interference takes place could be controlled by modulating the thickness of the first low-refractive-index layer. Moreover, a two-dimensional periodic pattern was incorporated into an upper GaN layer with the designed Bragg mirror and it was shown that a lattice constant of ~800 nm was optimal for light extraction. We believe that tailoring the radiation profile of light emitters by coherent coupling with designed high-reflectivity mirrors will be a promising route to overcome the efficiency limit of current semiconductor LED devices.

  2. Treatment of Synthetic Textile Wastewater by Combination of Coagulation/Flocculation Process and Electron Beam Irradiation

    Directory of Open Access Journals (Sweden)

    Fateme Anvari

    2014-06-01

    Full Text Available Introduction: Textile wastewaters from dyeing and finishing processes are heavily polluted with dyes, textile auxiliaries and chemicals and have a broad range of pH, high COD concentration and suspended particles. In this study, the efficiency of color and turbidity removal from synthetic textile wastewater samples were investigated by combined process of coagulation/ flocculation and electron beam irradiation. Materials and Methods: The experiments have been done on model dye solution samples which prepared from ten dyes that are supplied from Yazd Baff textile factory. Aluminum sulphate was employed to determine the optimum conditions for removal of turbidity by jar-test experiments. Then samples were irradiated by 10 MeV electron beam of Rhodotron TT200 accelerator at different doses of 1, 3 and 6 kGy. Absorption spectra of the samples were measured using UV-Vis spectrophotometer (Perkin Elmer, Lambda 25. The pH and turbidity values of the solutions were measured by a Metrohm 827 model pH meter and 2100AN turbidimeter (Hach company. Results: According to results, the degree of decoloration and turbidity removal of synthetic dye solutions increased dramatically when the alum concentration increased and reached to 64% and 90% respectively at 112 ppm. After irradiation, it is observed that absorbance at 540 nm decreased rapidly by increasing of radiation dose, because of macromolecules degradation and then decreased slowly and degree of decoloration reached to 95%. The amount of pH was decreased by irradiation and then changed very slowly or remained constant with increasing irradiation dose. Conclusion: The above results indicate that combination of coagulation/ flocculation and irradiation of 10 MeV electron beam is so effective for turbidity removal and decoloration. Coagulation process eliminates suspended particles from disperse dyes effectively, while destruction of soluble dye molecules happen by irradiation that increase decoloration

  3. Removal of diclofenac from surface water by electron beam irradiation combined with a biological aerated filter

    Science.gov (United States)

    He, Shijun; Wang, Jianlong; Ye, Longfei; Zhang, Youxue; Yu, Jiang

    2014-12-01

    The degradation of DCF was investigated in aqueous solution by using electron beam (EB) technology. When the initial concentration was between 10 and 40 mg/L, almost 100% of the DCF was degraded at a dose of 0.5 kGy. However, only about 6.5% of DCF was mineralized even at 2 kGy according to total organic carbon (TOC) measurements. A combined process of EB and biological aerated filter (BAF) was therefore developed to enhance the treatment of DCF contaminated surface water. The effluent quality of combined process was substantially improved by EB pretreatment due to the degradation of DCF and related intermediates. Both irradiation and biological treatment reduced the toxicity of the treated water. The experimental results showed that EB is effective for removing DCF from artificial aqueous solution and real surface water.

  4. Optical coherence tomography and confocal fluorescence microscopy as a combined method for studying morphological changes in lung dynamics

    Science.gov (United States)

    Gaertner, Maria; Cimalla, Peter; Knels, Lilla; Meissner, Sven; Schnabel, Christian; Kuebler, Wolfgang M.; Koch, Edmund

    2011-03-01

    Acute lung injury (ALI) is a severe pulmonary disease leading to hypoxemia accompanied by a reduced compliance and partial edema of the lung. Most of the patients have to be ventilated to compensate for the lack of oxygen. The treatment is strongly connected with ventilator induced lung injury (VILI), which is believed to introduce further stress to the lung and changes in its elastic performance. A thorough understanding of the organs micro-structure is crucial to gain more insight into the course of the disease. Due to backscattering of near-infrared light, detailed description of lung morphology can be obtained using optical coherence tomography (OCT), a non-invasive, non-contact, high resolution and fast three-dimensional imaging technique. One of its drawbacks lies in the non-specificity of light distribution in relation to defined substances, like elastic biomolecules. Using fluorescence detection, these chemical components can be visualized by introducing specifically binding fluorophores. This study presents a combined setup for studying alveolar compliance depending on volume changes and elastic fiber distributions. Simultaneously acquired OCT and confocal fluorescence images allow an entire view into morphological rearrangements during ventilation for an ex vivo mouse model using continuous pulmonary airway pressure at different values.

  5. Terahertz Coherent Synchrotron Radiation from Femtosecond Laser Modulation of the Electron Beam at the Advanced Light Source

    CERN Document Server

    Byrd, John; Martin, Michael C; Robin, David; Sannibale, Fernando; Schönlein, Robert W; Zholents, Alexander; Zolotorev, Max S

    2005-01-01

    At the Advanced Light Source (ALS), the "femtoslicing" beamline is in operation since 1999 for the production of x-ray synchrotron radiation pulses with femtosecond duration. The mechanism used for generating the short x-ray pulses induces at the same time temporary structures in the electron bunch longitudinal distribution with very short characteristic length. Such structures emit intense coherent synchrotron radiation (CSR) in the terahertz frequency range. This CSR, whose measured intensity is routinely used as a diagnostics for the tune-up of the femtoslicing experiments, represents a potential source of terahertz radiation with very interesting features. Several measurements have been performed for its characterization and in this paper an updated description of the experimental results and of their interpretation is presented.

  6. Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure

    NARCIS (Netherlands)

    Sarin, Jaakko K; Rieppo, Lassi; Brommer, Harold; Afara, Isaac O.; Saarakkala, Simo; Töyräs, Juha

    2017-01-01

    Conventional arthroscopic evaluation of articular cartilage is subjective and poorly reproducible. Therefore, implementation of quantitative diagnostic techniques, such as near infrared spectroscopy (NIRS) and optical coherence tomography (OCT), is essential. Locations (n = 44) with various

  7. Coherent backscattering in the soft x-ray region

    International Nuclear Information System (INIS)

    Matone, G.; Luccio, A.

    1986-06-01

    It is shown that coherent polarized soft x-rays can be produced by a combination of two techniques - stimulated amplification of laser light in a magnetic undulator, and Compton scattering of laser photons on an electron beam. In the combined technique, laser radiation is Compton scattered from a relativistic electron beam, whose current or charge density is periodically modulated. An electron beam and a laser beam propagate through an undulator along the same line. Inside the undulator, the laser electromagnetic waste produces a modulation of the electron energy. After some drift space, the modulation of the electron energy transforms into a modulation of the beam longitudinal charge density. The laser photons are reflected by a concave mirror against the electrons and are backscattered. In the process, their energy is greatly increased. If the electron and laser photon energy are matched properly, the modulated electron beam may act as a moving diffraction grating, and the backscattered x-rays show a high degree of coherence. The mechanism of modulation is described. The effects of electron beam energy spread, finite electron beam emittance, and undulator imperfections are discussed. The theory of scattering of a light wave by a bunched electron beam and the properties of the scattered radiation are examined

  8. Demonstration and implications when 50% beam combiners can behave as 0% or 100% reflector/transmitter inside some interferometers

    Science.gov (United States)

    Roychoudhuri, ChandraSekhar

    2017-08-01

    The purpose of this paper is to embolden students to raise basic questions regarding the feasibility of "indivisible single photon interference". We do this by presenting experimental results of well-known classical Mach-Zehnder interferometer (MZI) under two different conditions of beam alignment. We routinely do such experiments in our laboratories. In the first case, we align the light beams on the beam combiner (BC) with their Poynting vectors as perfectly collinear. The 50% dielectric boundary can now transmit 100% of the energy of both the beams into either one of the two MZI output ports, depending upon the relative phase between the two beams combined on the BC from the opposite directions. The dielectric boundary layer actively re-directs the energy from one beam to the other. This is pure classical superposition effect. In the second case, we combine the two beams on the BC with a small intersecting angle. Now the BC functions as a 50% beam splitter to both the beams. One can see spatial fringes as the relative phase varies with spatial distance by placing a photo detector array after the BC. At very low intensity, the quantum properties of the photo detector will become apparent because the photo electrons are discrete and are always bound quantum mechanically to its host molecular assembly; and not because light is definitely quantized. Students can learn to distinguish the pedagogical difference between the Superposition Principle (linear sum of wave amplitudes) and the Superposition Effect (square modulus of the sum of all the wave-induced stimulations) as observable intensity variations due to interaction with materials, classical or quantum.

  9. Electron beam combined with hydrothermal treatment for enhancing the enzymatic convertibility of sugarcane bagasse

    Science.gov (United States)

    Duarte, C. L.; Ribeiro, M. A.; Oikawa, H.; Mori, M. N.; Napolitano, C. M.; Galvão, C. A.

    2012-08-01

    The use of microbial cellulolytic enzymes is the most efficient process to liberate glucose from cellulose in biomass without the formation of fermentation inhibitors. A combination of pretreatment technologies is an alternative way to increase the access of enzymes to cellulose, and consequently, the conversion yield. In this way, the present study reports on the enzymatic hydrolysis of SCB submitted to three kinds of pretreatment: electron beam processing (EBP), and EBP followed by hydrothermal (TH) and diluted acid (AH) treatment. SCB samples were irradiated using a radiation dynamics electron beam accelerator, and then submitted to thermal and acid (0.1% sulfuric acid) hydrolysis for 40 and 60 min at 180 °C. These samples were submitted to enzymatic hydrolysis (EH) using commercial preparations, including Celluclast 1.5 L and beta-glycosidase. The addition of diluted acid improved TH treatment allowing for a shorter application time. EBP with 50 kGy increased the enzymatic hydrolysis yield of cellulose by 20% after TH and 30% after AH.

  10. Application of electron beam irradiation combined to conventional treatment to treat industrial effluents

    Science.gov (United States)

    Duarte, C. L.; Sampa, M. H. O.; Rela, P. R.; Oikawa, H.; Cherbakian, E. H.; Sena, H. C.; Abe, H.; Sciani, V.

    2000-03-01

    A preliminary study to combine electron beam irradiation process with biological treatment was carried out. Experiments were conducted using samples from a governmental wastewater treatment plant (WTP) that receives about 20% of industrial wastewater, with the objective of destroying the refractory organic pollutants and to obtain a better performance of this plant. Samples from five different steps of WTP were collected and irradiated in the electron beam accelerator in a batch system with 5.0, 10.0 and 20.0 kGy doses. The main results showed a removal of 99% of all organic compound analysed in the industrial receiver unit (IRU) effluent and in the coarse bar screen (CBS) effluent with a 20 kGy dose, and for the medium bar screen (MBS) and primary sedimentation (PS) effluent a 10 kGy dose was sufficient. In the case of final effluent (FE), a dose of 5 kGy removed the remaining organic compounds and dyes present after biological treatment.

  11. Tests of Local Hadron Calibration Approaches in ATLAS Combined Beam Tests

    CERN Document Server

    Grahn, KJ; The ATLAS collaboration; Pospelov, G

    2010-01-01

    Three ATLAS calorimeters in the region of the forward crack at $|eta| = 3.2$ in the nominal ATLAS setup and a typical section of the two barrel calorimeters at $|eta| = 0.45$ of ATLAS have been exposed to combined beam tests with single electrons and pions. Detailed shower shape studies of electrons and pions with comparisons to various Geant4 based simulations utilizing different physics lists are presented for the endcap testbeam. The local hadronic calibration approach as used in the full Atlas setup has been applied to the endcap testbeam data. An extension of it using layer correlations has been tested with the barrel test beam data. Both methods utilize modular correction steps based on shower shape variables to correct for invisible energy inside the reconstructed clusters in the calorimeters (compensation) and for lost energy deposits outside of the reconstructed clusters (dead material and out-of-cluster deposits). Results for both methods and comparisons to Monte-Carlo simulations are presented.

  12. TESTBEAM COORDINATION: 2nd ATLAS H8 Combined Test Beam Workshop

    CERN Multimedia

    Di Girolamo, B

    The second ATLAS H8 Combined Test Beam Workshop took place at CERN on 24th and 25th November. After a first workshop in July to warm up the atmosphere, a lot of work has been done in the meantime and there was a clear need to get together again before the end of 2003. The morning of the first day has been devoted to an assessment of the status of the various elements needed for next year’s test beam in H8. Each sub-detector has been presenting the status of preparation, as well as the work in progress and still to be done. The picture has been completed with the first plans for the DAQ from the point of view of the sub-detectors requirements, and a status of the LVL1 elements. Finally, the status and the timescale for availability of the LVL2 and EF infrastructure have been presented. The final draft layout of the sub-detectors has been discussed (figures 1 and 2). A more detailed description of the layout is in preparation to include more information on dead material and on the ancillary detectors (scint...

  13. Terahertz Coherent Synchrotron Radiation from Femtosecond Laser Modulation of the Electron Beam at the Advanced Light Source

    International Nuclear Information System (INIS)

    Byrd, John M.; Hao, Zhao; Martin, Michael C.; Robin, David S.; Sannibale, Fernando; Schoenlein, Robert W.; Zholents, Alexander A.; Zolotorev, Max S.

    2005-01-01

    At the Advanced Light Source (ALS), the ''femtoslicing'' beamline is in operation since 1999 for the production of x-ray synchrotron radiation pulses with femtosecond duration. The mechanism used for generating the short x-ray pulses induces at the same time temporary structures in the electron bunch longitudinal distribution with very short characteristic length. Such structures emit intense coherent synchrotron radiation (CSR) in the terahertz frequency range. These CSR pulses were first observed at the ALS, and the measurement of their intensity is now routinely used as a diagnostics for the tune-up of the femtoslicing x-ray experiments. At the same time, these CSR pulses synchronous with the modulating laser, represent a potential source of terahertz radiation with very interesting features. Several measurements have been performed for their characterization and in this paper we present an updated description of the experimental results and of their interpretation. In particular, we include more data on the interesting interaction, previously observed at the ALS, between the slicing and the microbunching instability (MBI), where under particular circumstances, the slicing seems to trigger the onset of the instability

  14. Continuous and pulsed laser high power beam combiner for additive manufacturing applications

    Science.gov (United States)

    Bassignana, Marta; Califano, Alessio; Pescarmona, Francesco; Braglia, Andrea; Perrone, Guido

    2018-02-01

    Laser-based additive manufacturing (AM) from metal powders is emerging as the new industrial revolution, although current fabrication approaches still require long mechanical post-processing to improve the final surface quality and meet the design tolerances. To overcome this limitation, the next generation machines are expected to complement laser AM with laser ablation (LA) to implement surface finishing and micro texturing already during the device growth process. With this aim, a new beam combiner to allow the real-time interchange of additive and subtractive processes using the same scanner head has been designed. Extensive tests have been carried out using a 6 kW continuous-wave laser similar to that used for the metal powder fusion and a nanosecond 100W pulsed source similar to that used for laser ablation.

  15. JouFLU: upgrades to the fiber linked unit for optical recombination (FLUOR) interferometric beam combiner.

    Science.gov (United States)

    Scott, N. J.; Lhomé, E.; ten Brummelaar, T. A.; Coudé du Foresto, V.; Millan-Gabet, R.; Sturmann, J.; Sturmann, L.

    2014-07-01

    The Fiber Linked Unit for Optical Recombination (FLUOR) is a precision interferometric beam combiner operating at the CHARA Array on Mt. Wilson, CA. It has recently been upgraded as part of a mission known as "Jouvence of FLUOR" or JouFLU. As part of this program JouFLU has new mechanic stages and optical payloads, new alignment systems, and new command/control software. Furthermore, new capabilities have been implemented such as a Fourier Transform Spectrograph (FTS) mode and spectral dispersion mode. These upgrades provide new capabilities to JouFLU as well as improving statistical precision and increasing observing efficiency. With these new systems, measurements of interferometric visibility to the level of 0.1% precision are expected on targets as faint as 6th magnitude in the K band. Here we detail the upgrades of JouFLU and report on its current status.

  16. Accessible coherence and coherence distribution

    Science.gov (United States)

    Ma, Teng; Zhao, Ming-Jing; Zhang, Hai-Jun; Fei, Shao-Ming; Long, Gui-Lu

    2017-04-01

    The definition of accessible coherence is proposed. Through local measurement on the other subsystem and one-way classical communication, a subsystem can access more coherence than the coherence of its density matrix. Based on the local accessible coherence, the part that cannot be locally accessed is also studied, which we call it remaining coherence. We study how the bipartite coherence is distributed by partition for both l1 norm coherence and relative entropy coherence, and the expressions for local accessible coherence and remaining coherence are derived. We also study some examples to illustrate the distribution.

  17. Electron-beam and combined e-b and microwave processing of dried food ingredients

    International Nuclear Information System (INIS)

    Ferdes, O.; Minea, R.; Martin, D.; Tirlea, A.; Badea, M.; Oproiu, C.

    1998-01-01

    Complete text of publication follows. There are summarized and presented the results on the irradiated dried food ingredients, as starches, flour, spices, enzymes, pigments. It has investigated the electron-beam and microwave processing to achieve the hygienic and microbiological quality requirements for these materials. There are presented the results regarding the e-b and microwave effects on the main specific parameters (nutritional; microbiological; physical and chemical) for each item. Irradiation has carried out to different electron accelerators, mainly to ALIN-7 linac (W e ∼6 MeV) and using a special designed microwave equipment (2.45 GHz magnetron of 850 W maximum output power). The samples have been irradiated up to 25 kGy (dose rate ∼ 2.0 kGy/min) and there were treated by microwaves (250 W-550 W) for different exposure time. There have analyzed and presented the influence of these two physical fields on some common physical, biochemical and microbiological properties (mainly the total germ count, CFU/g) of these food materials. The main technological and physical characteristics of the materials are preserved, under irradiation up to 10 kGy and microwave treatment in the case of satisfying the national requirements for food and food grade additives microbiological load. The combined treatment seems to be present a synergistic effect arising on non-thermal basis. From these results it could be pointed out that electron-beam and microwave treatment is feasible and represents an alternative to other hygienization techniques for the dried food ingredients. It should be considered that combined treatments lead to reducing irradiation dose without losing the microbicidal effects

  18. Interaction of electron beams with optical nanostructures and metamaterials: from coherent photon sources towards shaping the wave function

    Science.gov (United States)

    Talebi, Nahid

    2017-10-01

    Investigating the interaction of electron beams with materials and light has been a field of research for more than a century. The field was advanced theoretically by the rise of quantum mechanics and technically by the introduction of electron microscopes and accelerators. It is possible nowadays to uncover a multitude of information from electron-induced excitations in matter by means of advanced techniques like holography, tomography, and, most recently, photon-induced near-field electron microscopy. The question is whether the interaction can be controlled in an even, more efficient way in order to unravel important questions like modal decomposition of the electron-induced polarization by performing experiments with better spatial, temporal, and energy resolutions. This review discusses recent advances in controlling electron and light interactions at the nanoscale. Theoretical and numerical aspects of the interaction of electrons with nanostructures and metamaterials will be discussed with the aim of understanding the mechanisms of radiation in the interaction of electrons with even more sophisticated structures. Based on these mechanisms of radiation, state-of-the art and novel electron-driven few-photon sources will be discussed. Applications of such sources to gain an understanding of quantum optical effects and also to perform spectral interferometry with electron microscopes will be covered. In an inverse approach, as in the case of the inverse Smith-Purcell effect, laser-induced excitations of nanostructures can cause electron beams traveling in the near-field of such structures to accelerate, provided a synchronization criterion is satisfied. This effect is the basis for linear dielectric and metallic electron accelerators. Moreover, acceleration is accompanied by bunching of the electrons. When single electrons are considered, an efficient design of nanostructures can lead to the shaping of the electron wave function travelling adjacent to them, for

  19. Study of combined concurrent chemoradiotherapy using proton beam and X-ray

    International Nuclear Information System (INIS)

    Sasaki, Makoto; Tamamura, Hiroyasu; Shibata, Satoshi

    2016-01-01

    Esophageal cancer and head and neck cancer are prone to metastases in lymph node since early disease stage. In treatment for these tumors, it is necessary to consider overall treatment method together with treatment to the wide preventing region as well as to the local region including a tumor and a lymph node metastasis. Although a concurrent chemoradiotherapy is recommended as a standard treatment to esophageal cancer of stage I ∼ III as well as a surgical operation, the adverse event to the surrounding organs by a high dose x-ray irradiation both in wide and local region is a significant problem. Therefore, the new 'combined concurrent chemoradiotherapy', which changed a part of the x-ray irradiation in conventional concurrent chemoradiotherapy to proton beam irradiation with the high local concentration, was contrived in this hospital. In order to achieve this treatment, we constructed the system which enables the overall evaluation of the prescription dose and dose distribution by accumulating the ones independently calculated in x-ray radiotherapy planning and proton radiotherapy planning. In addition, in order to achieve the safe and effective treatment in every case, we established the treatment practical use with which many medical staff, such as gastrointestinal physicians, surgeons, radiation oncologists, medical physicists, radiological technologists, and nurses in a general hospital, could cooperate. As a result, the serious acute-phase adverse event is not admitted in our early experience of the combined concurrent chemoradiotherapy for advanced esophageal cancer. By a follow-up including late-onset adverse event, it is expected that the combined concurrent chemoradiotherapy can reduce influence to surrounding organs. On the other hand, it is also important to establish the most suitable tumor control protocol. As a result of the experiments in the Wakasa-wan energy research center, it was found that the cytotoxic effect by irradiation

  20. Concepts, features, and design of a sixteen-to-four beam combiner for ILSE [Induction Linac Systems Experiment

    International Nuclear Information System (INIS)

    Judd, D.L.; Celata, C.; Close, E.; Faltens, A.; Hahn, K.; La Mon, K.; Lee, E.P.; Smith, L.; Thur, W.

    1989-03-01

    Sixteen intense parallel ion beams are to be transversely combined into four by dispersionless double bends. Emittance growth due to electrostatic energy redistribution and to the geometry is evaluated. Most bending elements are electric, and alternate with AG electrostatic quadrupoles similar to those upstream. The final elements are magnetic, combining focusing and ''unbending''. Electrode shapes and pulsed-current arrays (having very small clearances), and mechanical and electric features of the combiner, and described. 1 ref., 7 figs

  1. Structure and properties of combined protective coatings with use high-current electron beam irradiation

    International Nuclear Information System (INIS)

    Ruzimov, Sh.M.

    2004-01-01

    Full text: Improvement of superficial materials and products is the important task. The high-efficiency vacuum - arc sources created recently open more ample opportunities for change of properties of a surface of metal materials. Now there is a number of known technologies on drawing coverings for updating a surface of working parts of metals. Today the protecting coatings, which were deposited on tools applied in electrochemical and chemical devices, acquired a great interest. It is known that some kinds of treatment, such as, for example, ion implantation, ion-assisted deposition of thin films, electron beam irradiation, CVD, PVD, etc. cannot result directly in desired effect. Therefore to resolve some application problems, one has to use combined methods of treatment, which allow one to resolve complicated serious problems of material science and industrial fields, for example, in space, automobile, aviation, ship building, etc. So, the goal of this work was to study the structure, element composition and properties of hybrid coatings on TiNi/Cr/Al 2 O 3 and TiN/Al 2 O 3 base, which were deposited on AISI 321 stainless steel before and after electron beam irradiation. A special attention was paid to studies of diffusion and mass-transfer processes. We applied XRD, RBS, AES, SEM with micro-analysis as well as corrosion in sulfur acid, adhesion and hardness tests. It had been demonstrated that these coatings were able to perform different functions as protecting coatings. Tests of TiN/Al 2 O 3 and TiN/Cr/Al 2 O 3 coatings, which were deposited on AISI 321 steel, after high-current electron beam irradiation demonstrated significant increase in corrosion resistance in H 2 SO 4 solution under 400 0 C temperature. Hardness and adhesion of these coatings to substrate increased, and significant decrease in friction wear of coating surfaces was found. In such a way, in this report it was demonstrated that hybrid coatings on TiN/Cr/Al 2 O 3 and TiN/Al 2 O 3 base after

  2. Effects of the combined action of axial and transversal loads on the failure time of a wooden beam under fire

    International Nuclear Information System (INIS)

    Nubissie, A.; Kingne Talla, E.; Woafo, P.

    2012-01-01

    Highlights: ► A wooden beam submitted to fire and axial and transversal loads is considered. ► The failure time is found to increase with the intensity of the loads. ► Implication for safety consideration is indicated. -- Abstract: This paper presents the variations of the failure time of a wooden beam (Baillonella toxisperma also called Moabi) in fire subjected to the combined effect of axial and transversal loads. Using the recommendation of the structural Eurocodes that the failure can occur when the deflection attains 1/300 of the length of the beam or when the bending moment attains the resistant moment, the partial differential equation describing the beam dynamics is solved numerically and the failure time calculated. It is found that the failure time decreases when either the axial or transversal loads increases.

  3. Ultrahigh-Resolution Combined Coronal Optical Coherence Tomography Confocal Scanning Ophthalmoscope (OCT/SLO): a pilot study

    International Nuclear Information System (INIS)

    Rosen, R.B.; Garcia, P.M.T.; Muldoon, T.O.; Velthoven van, M.E.J.; Cucu, R.G.; Podoleanu, A.G.; De Smet, M.D.

    2007-01-01

    To evaluate clinical images from a prototype ultrahigh resolution (UHR) combined coronal optical coherence tomography/confocal scanning ophthalmoscope (OCT/SLO) and to compare them to standard-resolution OCT/SLO images on the same patients. Cross-sectional pilot-study. Sixty-six eyes of 42 patients with various macular pathologies, such as age-related macular degeneration, macular edema, macular hole, central serous retinopathy, epiretinal membrane and posterior vitreous traction syndrome. Each subject was first scanned with a standard-resolution OCT/SLO that has an axial resolution of ∼ 10 micron. Immediately following, patients were scanned with the prototype UHR OCT/SLO device. The UHR system employs a compact super luminescent diode (SLD) with a 150 nm bandwidth centered at 890 nm, which allows imaging of the retina with an axial resolution of 3 microns. Both coronal and longitudinal OCT scans were acquired with each system, and compared side-by-side. Scan quality was assessed for the observer's ability to visualize the vitreo-retinal interface and retinal layers - in particular of the outer retina/RPE/choroidal interface, increased discrimination of pathological changes, and better signal intensity. Ultrahigh and standard-resolution coronal and longitudinal OCT/SLO images of macular pathologies. In the side-by-side comparison with the commercial standard-resolution OCT/SLO images, the scans in the Ultrahigh resolution OCT/SLO images were superior in 85 % of cases. Relatively poor quality images were attributed to lower signal-to-noise ratio, limited focusing, or media opacities. Several images that had a better signal intensity in the standard-resolution OCT/SLO system were found to show more retinal detail in the UHR system. In general, intraretinal layers in the UHR OCT/SLO images were better delineated in both coronal and longitudinal scans. Enhanced details were also seen in the outer retina/RPE/choroidal complex. The UHR OCT/SLO system produced better

  4. If Frisch is true - impacts of varying beam width, resolution, frequency combinations and beam overlap when retrieving liquid water content profiles

    Science.gov (United States)

    Küchler, N.; Kneifel, S.; Kollias, P.; Loehnert, U.

    2017-12-01

    Cumulus and stratocumulus clouds strongly affect the Earth's radiation budget and are a major uncertainty source in weather and climate prediction models. To improve and evaluate models, a comprehensive understanding of cloud processes is necessary and references are needed. Therefore active and passive microwave remote sensing of clouds can be used to derive cloud properties such as liquid water path and liquid water content (LWC), which can serve as a reference for model evaluation. However, both the measurements and the assumptions when retrieving physical quantities from the measurements involve uncertainty sources. Frisch et al. (1998) combined radar and radiometer observations to derive LWC profiles. Assuming their assumptions are correct, there will be still uncertainties regarding the measurement setup. We investigate how varying beam width, temporal and vertical resolutions, frequency combinations, and beam overlap of and between the two instruments influence the retrieval of LWC profiles. Especially, we discuss the benefit of combining vertically, high resolved radar and radiometer measurements using the same antenna, i.e. having ideal beam overlap. Frisch, A. S., G. Feingold, C. W. Fairall, T. Uttal, and J. B. Snider, 1998: On cloud radar and microwave radiometer measurements of stratus cloud liquid water profiles. J. Geophys. Res.: Atmos., 103 (18), 23 195-23 197, doi:0148-0227/98/98JD-01827509.00.

  5. A method to combine three dimensional dose distributions for external beam and brachytherapy radiation treatments for gynecological neoplasms

    International Nuclear Information System (INIS)

    Narayana, V.; Sahijdak, W.M.; Orton, C.G.

    1997-01-01

    Purpose: Radiation treatment of gynecological neoplasms, such as cervical carcinoma, usually combines external radiation therapy with one or more intracavitary brachytherapy applications. Although the dose from external beam radiation therapy and brachytherapy can be calculated and displayed in 3D individually, the dose distributions are not combined. At most, combined point doses are calculated for select points using various time-dose models. In this study, we present a methodology to combine external beam and brachytherapy treatments for gynecological neoplasms. Material and Methods: Three dimensional bio-effect treatment planning to obtain complication probability has been outlined. CT scans of the patient's pelvis with the gynecological applicator in place are used to outline normal tissue and tumor volumes. 3D external beam and brachytherapy treatment plans are developed separately and an external beam dose matrix and a brachytherapy dose matrix was calculated. The dose in each voxel was assumed to be homogeneous. The physical dose in each voxel of the dose matrix was then converted into extrapolated response dose (ERD) based on the linear quadratic model that accounts for the dose per fraction, number of fractions, dose rate, and complete or incomplete repair of sublethal damage (time between fractions). The net biological dose delivered was obtained by summing the ERD grids from external beam and brachytherapy since there was complete repair of sublethal damage between external beam and brachytherapy treatments. The normal tissue complication probability and tumor control probability were obtained using the biological dose matrix based on the critical element model. Results: The outlined method of combining external beam and brachytherapy treatments was implemented on gynecological treatments using an applicator for brachytherapy treatments. Conclusion: Implementation of the biological dose calculation that combine different modalities is extremely useful

  6. IEC 61267: Feasibility of type 1100 aluminium and a copper/aluminium combination for RQA beam qualities.

    Science.gov (United States)

    Leong, David L; Rainford, Louise; Zhao, Wei; Brennan, Patrick C

    2016-01-01

    In the course of performance acceptance testing, benchmarking or quality control of X-ray imaging systems, it is sometimes necessary to harden the X-ray beam spectrum. IEC 61267 specifies materials and methods to accomplish beam hardening and, unfortunately, requires the use of 99.9% pure aluminium (Alloy 1190) for the RQA beam quality, which is expensive and difficult to obtain. Less expensive and more readily available filters, such as Alloy 1100 (99.0% pure) aluminium and copper/aluminium combinations, have been used clinically to produce RQA series without rigorous scientific investigation to support their use. In this paper, simulation and experimental methods are developed to determine the differences in beam quality using Alloy 1190 and Alloy 1100. Additional simulation investigated copper/aluminium combinations to produce RQA5 and outputs from this simulation are verified with laboratory tests using different filter samples. The results of the study demonstrate that although Alloy 1100 produces a harder beam spectrum compared to Alloy 1190, it is a reasonable substitute. A combination filter of 0.5 mm copper and 2 mm aluminium produced a spectrum closer to that of Alloy 1190 than Alloy 1100 with the added benefits of lower exposures and lower batch variability. Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  7. Fourier Domain Optical Coherence Tomography integrated into a slit lamp; a novel technique combining anterior and posterior segment OCT

    NARCIS (Netherlands)

    Stehouwer, M.; Verbraak, F. D.; de Vries, H.; Kok, P. H. B.; van Leeuwen, T. G.

    2010-01-01

    Purpose Fourier Domain Optical Coherence Tomography (FD-OCT) provides high resolution cross-sectional images of the retina and the anterior segment. It has become an important tool in ophthalmology in the examination, diagnosis, and treatment of important and common diseases. Present OCT imaging

  8. Experimental generation of optical coherence lattices

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yahong; Cai, Yangjian, E-mail: serpo@dal.ca, E-mail: yangjiancai@suda.edu.cn [College of Physics, Optoelectronics and Energy and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215006 (China); Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province and Key Lab of Modern Optical Technologies of Education Ministry of China, Soochow University, Suzhou 215006 (China); Ponomarenko, Sergey A., E-mail: serpo@dal.ca, E-mail: yangjiancai@suda.edu.cn [Department of Electrical and Computer Engineering, Dalhousie University, Halifax, Nova Scotia B3J 2X4 (Canada)

    2016-08-08

    We report experimental generation and measurement of recently introduced optical coherence lattices. The presented optical coherence lattice realization technique hinges on a superposition of mutually uncorrelated partially coherent Schell-model beams with tailored coherence properties. We show theoretically that information can be encoded into and, in principle, recovered from the lattice degree of coherence. Our results can find applications to image transmission and optical encryption.

  9. Coherence vortices in Mie scattering of statistically stationary partially coherent fields.

    Science.gov (United States)

    Marasinghe, Madara L; Premaratne, Malin; Paganin, David M

    2010-03-29

    Points within a fully coherent complex scalar optical field, where the amplitude is identically zero but the optical phase has a jump discontinuity, have been widely investigated by the singular-optics community. More recent researches have extended the domain of singular optics to include partially coherent fields. For example, in coherence vortices the phase of the two-point spectral degree of coherence of a partially coherent field exhibits vortex structure around a point where the magnitude of the spectral degree of coherence vanishes. We show that the spectral degree of coherence of Mie scattered partially coherent statistically stationary electromagnetic fields exhibits a rich set of coherence vortices in both the internal and external fields. Specifically, we look at Mie scattering of a stationary beam from a dielectric sphere and study the formation of coherence vortices and their evolution with both the properties of the scattering sphere, and of the incident partially coherent beam.

  10. Note: Determination of torsional spring constant of atomic force microscopy cantilevers: Combining normal spring constant and classical beam theory

    DEFF Research Database (Denmark)

    Álvarez-Asencio, R.; Thormann, Esben; Rutland, M.W.

    2013-01-01

    A technique has been developed for the calculation of torsional spring constants for AFM cantilevers based on the combination of the normal spring constant and plate/beam theory. It is easy to apply and allow the determination of torsional constants for stiff cantilevers where the thermal power...

  11. Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer

    Science.gov (United States)

    Johansson, Silvia; Åström, Lennart; Sandin, Fredrik; Isacsson, Ulf; Montelius, Anders; Turesson, Ingela

    2012-01-01

    Proton boost of 20 Gy in daily 5 Gy fractions followed by external beam radiotherapy (EBRT) of 50 Gy in daily 2 Gy fractions were given to 278 patients with prostate cancer with T1b to T4N0M0 disease. Fifty-three percent of the patients received neoadjuvant androgen deprivation therapy (N-ADT). The medium followup was 57 months. The 5-year PSA progression-free survival was 100%, 95%, and 74% for low-, intermediate-, and high-risk patients, respectively. The toxicity evaluation was supported by a patient-reported questionnaire before every consultant visit. Cumulative probability and actuarial prevalence of genitourinary (GU) and gastrointestinal (GI) toxicities are presented according to the RTOG classification. N-ADT did not influence curability. Mild pretreatment GU-symptoms were found to be a strong predictive factor for GU-toxicity attributable to treatment. The actuarial prevalence declined over 3 to 5 years for both GU and GI toxicities, indicating slow resolution of epithelial damage to the genitourinary and gastrointestinal tract. Bladder toxicities rather than gastrointestinal toxicities seem to be dose limiting. More than 5-year followup is necessary to reveal any sign of true progressive late side effects of the given treatment. Hypofractionated proton-boost combined with EBRT is associated with excellent curability of localized PC and acceptable frequencies of treatment toxicity. PMID:22848840

  12. Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Silvia Johansson

    2012-01-01

    Full Text Available Proton boost of 20 Gy in daily 5 Gy fractions followed by external beam radiotherapy (EBRT of 50 Gy in daily 2 Gy fractions were given to 278 patients with prostate cancer with T1b to T4N0M0 disease. Fifty-three percent of the patients received neoadjuvant androgen deprivation therapy (N-ADT. The medium followup was 57 months. The 5-year PSA progression-free survival was 100%, 95%, and 74% for low-, intermediate-, and high-risk patients, respectively. The toxicity evaluation was supported by a patient-reported questionnaire before every consultant visit. Cumulative probability and actuarial prevalence of genitourinary (GU and gastrointestinal (GI toxicities are presented according to the RTOG classification. N-ADT did not influence curability. Mild pretreatment GU-symptoms were found to be a strong predictive factor for GU-toxicity attributable to treatment. The actuarial prevalence declined over 3 to 5 years for both GU and GI toxicities, indicating slow resolution of epithelial damage to the genitourinary and gastrointestinal tract. Bladder toxicities rather than gastrointestinal toxicities seem to be dose limiting. More than 5-year followup is necessary to reveal any sign of true progressive late side effects of the given treatment. Hypofractionated proton-boost combined with EBRT is associated with excellent curability of localized PC and acceptable frequencies of treatment toxicity.

  13. Proposal of coherent Cherenkov radiation matched to circular plane wave for intense terahertz light source

    International Nuclear Information System (INIS)

    Sei, Norihiro; Sakai, Takeshi; Hayakawa, Ken; Tanaka, Toshinari; Hayakawa, Yasushi; Nakao, Keisuke; Nogami, Kyoko; Inagaki, Manabu

    2015-01-01

    Highlights: • We proposed a new intense terahertz-wave source based on coherent Cherenkov radiation (CCR). • A hollow conical dielectric is used to generate the CCR beam. • The wave front of the CCR beam can be matched to the basal plane. • The peak-power of the CCR beam is above 1 MW per micropulse with a short interval of 350 ps. - Abstract: We propose a high-peak-power terahertz-wave source based on an electron accelerator. By passing an electron beam through a hollow conical dielectric with apex facing the incident electron beam, the wave front of coherent Cherenkov radiation generated on the inner surface of the hollow conical dielectric matches the basal plane. Using the electron beam generated at the Laboratory for Electron Beam Research and Application at Nihon University, the calculated power of coherent Cherenkov radiation that matched the circular plane (CCR-MCP) was above 1 MW per micropulse with a short interval of 350 ps, for wavelengths ranging from 0.5 to 5 mm. The electron beam is not lost for generating the CCR-MCP beam by using the hollow conical dielectric. It is possible to combine the CCR-MCP beams with other light sources based on an accelerator

  14. Human perception of indoor environment generated by chilled ceiling combined with mixing ventilation or localised chilled beam under cooling mode

    DEFF Research Database (Denmark)

    Bolashikov, Zhecho Dimitrov; Nygaard, Linette; Uth, Simon C.

    2014-01-01

    Experiments with 24 subjects were performed to study and compare the human perception of the indoor environment under summer conditions generated by a chilled ceiling combined with overhead mixing ventilation and localised chilled beam. The experiments were performed in an experimental chamber (4....../s during the 20 min period of physical activity, when the occupant was not at the desk with the localised chilled beam, resulting in increase of the air temperature in the room. Subjects used questionnaires to answer on thermal sensation and acceptability, perceived air quality, air movement and SBS...

  15. Fabrication of nanoscale gaps using a combination of self-assembled molecular and electron beam lithographic techniques

    International Nuclear Information System (INIS)

    Negishi, R.; Hasegawa, T.; Terabe, K.; Aono, M.; Ebihara, T.; Tanaka, H.; Ogawa, T.

    2006-01-01

    We have developed and tested a new method of fabricating nanogaps using a combination of self-assembled molecular and electron beam lithographic techniques. The method enables us to control the gap size with an accuracy of approximately 2 nm and designate the positions where the nanogaps should be formed with high-resolution patterning by using electron beam lithography. We have demonstrated the utility of the fabricated nanogaps by measuring a single electron tunneling phenomenon through dodecanethiol-coated Au nanoparticles placed in the fabricated nanogap

  16. Laser systems configured to output a spectrally-consolidated laser beam and related methods

    Science.gov (United States)

    Koplow, Jeffrey P [San Ramon, CA

    2012-01-10

    A laser apparatus includes a plurality of pumps each of which is configured to emit a corresponding pump laser beam having a unique peak wavelength. The laser apparatus includes a spectral beam combiner configured to combine the corresponding pump laser beams into a substantially spatially-coherent pump laser beam having a pump spectrum that includes the unique peak wavelengths, and first and second selectively reflective elements spaced from each other to define a lasing cavity including a lasing medium therein. The lasing medium generates a plurality of gain spectra responsive to absorbing the pump laser beam. Each gain spectrum corresponds to a respective one of the unique peak wavelengths of the substantially spatially-coherent pump laser beam and partially overlaps with all other ones of the gain spectra. The reflective elements are configured to promote emission of a laser beam from the lasing medium with a peak wavelength common to each gain spectrum.

  17. Photon reconstruction in the ATLAS Inner Detector and Liquid Argon Barrel Calorimeter at the 2004 Combined Test Beam

    CERN Document Server

    Abat, E; Addy, T N; Adragna, P; Aharrouche, M; Ahmad, A; Akesson, T.P A; Aleksa, M; Alexa, C; Anderson, K; Andreazza, A; Anghinolfi, F; Antonaki, A; Arabidze, G; Arik, E; Atkinson, T; Baines, J; Baker, O K; Banfi, D; Baron, S; Barr, A J; Beccherle, R; Beck, H P; Belhorma, B; Bell, P J; Benchekroun, D; Benjamin, D P; Benslama, K; Bergeaas Kuutmann, E; Bernabeu, J; Bertelsen, H; Binet, S; Biscarat, C; Boldea, V; Bondarenko, V G; Boonekamp, M; Bosman, M; Bourdarios, C; Broklova, Z; Burckhart-Chromek, D; Bychkov, V; Callahan, J; Calvet, D; Canneri, M; Capeans Garrido, M; Caprini, M; Cardiel Sas, L; Carli, T; Carminati, L; Carvalho, J; Cascella, M; Castillo, M V; Catinaccio, A; Cauz, D; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Cetin, S A; Chen, H; Cherkaoui, R; Chevalier, L; Chevallier, F; Chouridou, S; Ciobotaru, M; Citterio, M; Clark, A; Cleland, B; Cobal, M; Cogneras, E; Conde Muino, P; Consonni, M; Constantinescu, S; Cornelissen, T; Correard, S; Corso-Radu, A; Costa, G; Costa, M J; Costanzo, D; Cuneo, S; Cwetanski, P; Da Silva, D; Dam, M; Dameri, M; Danielsson, H O; Dannheim, D; Darbo, G; Davidek, T; De, K; Defay, P O; Dekhissi, B; Del Peso, J; Del Prete, T; Delmastro, M; Derue, F; Di Ciaccio, L; Di Girolamo, B; Dita, S; Dittus, F; Djama, F; Djobava, T; Dobos, D; Dobson, M; Dolgoshein, B A; Dotti, A; Drake, G; Drasal, Z; Dressnandt, N; Driouchi, C; Drohan, J; Ebenstein, W L; Eerola, P; Efthymiopoulos, I; Egorov, K; Eifert, T F; Einsweiler, K; El Kacimi, M; Elsing, M; Emelyanov, D; Escobar, C; Etienvre, A I; Fabich, A; Facius, K; Idrissi Fakhr-Eddine, A; Fanti, M; Farbin, A; Farthouat, P; Fassouliotis, D; Fayard, L; Febbraro, R; Fedin, O L; Fenyuk, A; Fergusson, D; Ferrari, P; Ferrari, R; Ferreira, B C; Ferrer, A; Ferrere, D; Filippini, G; Flick, T; Fournier, D; Francavilla, P; Francis, D; Froeschl, R; Froidevaux, D; Fullana, E; Gadomski, S; Gagliardi, G; Gagnon, P; Gallas, M; Gallop, B J; Gameiro, S; Gan, K K; Garcia, R; Garcia, C; Gavrilenko, I L; Gemme, C; Gerlach, P; Ghodbane, N; Giakoumopoulou, V; Giangiobbe, V; Giokaris, N; Glonti, G; Gottfert, T.; Golling, T; Gollub, N; Gomes, A; Gomez, M D; Gonzalez-Sevilla, S; Goodrick, M J; Gorfine, G; Gorini, B; Goujdami, D; Grahn, K J; Grenier, P; Grigalashvili, N; Grishkevich, Y; Grosse-Knetter, J; Gruwe, M; Guicheney, C; Gupta, A; Haeberli, C; Hartel, R.; Hajduk, Z; Hakobyan, H; Hance, M; Hansen, J D; Hansen, P H; Hara, K; Harvey, A., Jr; Hawkings, R J; Heinemann, F.E W; Henriques Correia, A; Henss, T; Hervas, L; Higon, E; Hill, J C; Hoffman, J; Hostachy, J Y; Hruska, I; Hubaut, F; Huegging, F; Hulsbergen, W; Hurwitz, M; Iconomidou-Fayard, L; Jansen, E; Jen-La Plante, I; Johansson, P.D C; Jon-And, K; Joos, M; Jorgensen, S; Joseph, J; Kaczmarska, A; Kado, M; Karyukhin, A; Kataoka, M; Kayumov, F; Kazarov, A; Keener, P T; Kekelidze, G D; Kerschen, N; Kersten, S; Khomich, A; Khoriauli, G; Khramov, E; Khristachev, A; Khubua, J; Kittelmann, T H; Klingenberg, R; Klinkby, E B; Kodys, P; Koffas, T; Kolos, S; Konovalov, S P; Konstantinidis, N; Kopikov, S; Korolkov, I; Kostyukhin, V; Kovalenko, S; Kowalski, T Z; Kruger, K.; Kramarenko, V; Kudin, L G; Kulchitsky, Y; Lacasta, C; Lafaye, R; Laforge, B; Lampl, W; Lanni, F; Laplace, S; Lari, T; Le Bihan, A C; Lechowski, M; Ledroit-Guillon, F; Lehmann, G; Leitner, R; Lelas, D; Lester, C G; Liang, Z; Lichard, P; Liebig, W; Lipniacka, A; Lokajicek, M; Louchard, L; Loureiro, K F; Lucotte, A; Luehring, F; Lund-Jensen, B; Lundberg, B; Ma, H; Mackeprang, R; Maio, A; Maleev, V P; Malek, F; Mandelli, L; Maneira, J; Mangin-Brinet, M; Manousakis, A; Mapelli, L; Marques, C; Marti i Garcia, S; Martin, F; Mathes, M; Mazzanti, M; McFarlane, K W; McPherson, R; Mchedlidze, G; Mehlhase, S; Meirosu, C; Meng, Z; Meroni, C; Mialkovski, V; Mikulec, B; Milstead, D; Minashvili, I; Mindur, B; Mitsou, V A; Moed, S; Monnier, E; Moorhead, G; Morettini, P; Morozov, S V; Mosidze, M; Mouraviev, S V; Moyse, E.W J; Munar, A; Myagkov, A; Nadtochi, A V; Nakamura, K; Nechaeva, P; Negri, A; Nemecek, S; Nessi, M; Nesterov, S Y; Newcomer, F M; Nikitine, I; Nikolaev, K; Nikolic-Audit, I; Ogren, H; Oh, S H; Oleshko, S B; Olszowska, J; Onofre, A; Padilla Aranda, C; Paganis, S; Pallin, D; Pantea, D; Paolone, V; Parodi, F; Parsons, J; Parzhitski, S; Pasqualucci, E; Passmore, S M; Pater, J; Patrichev, S; Peez, M; Perez Reale, V; Perini, L; Peshekhonov, V D; Petersen, J; Petersen, T C; Petti, R; Phillips, P W; Pilcher, J; Pina, J; Pinto, B; Podlyski, F; Poggioli, L; Poppleton, A; Poveda, J; Pralavorio, P; Pribyl, L; Price, M J; Prieur, D; Puigdengoles, C; Puzo, P; Ragusa, F; Rajagopalan, S; Reeves, K; Reisinger, I; Rembser, C; Bruckman de Renstrom, P.A.; Reznicek, P; Ridel, M; Risso, P; Riu, I; Robinson, D; Roda, C; Roe, S; Rohne, O.; Romaniouk, A; Rousseau, D; Rozanov, A; Ruiz, A; Rusakovich, N; Rust, D; Ryabov, Y F; Ryjov, V; Salto, O; Salvachua, B; Salzburger, A; Sandaker, H; Santamarina Rios, C.Santamarina; Santi, L; Santoni, C; Saraiva, J G; Sarri, F; Sauvage, G; Says, L P; Schaefer, M; Schegelsky, V A; Schiavi, C; Schieck, J; Schlager, G; Schlereth, J; Schmitt, C; Schultes, J; Schwemling, P; Schwindling, J; Seixas, J M; Seliverstov, D M; Serin, L; Sfyrla, A; Shalanda, N; Shaw, C; Shin, T; Shmeleva, A; Silva, J; Simion, S; Simonyan, M; Sloper, J E; Smirnov, S.Yu; Smirnova, L; Solans, C; Solodkov, A; Solovianov, O; Soloviev, I; Sosnovtsev, V V; Spano, F; Speckmayer, P; Stancu, S; Stanek, R; Starchenko, E; Straessner, A; Suchkov, S I; Suk, M; Szczygiel, R; Tarrade, F; Tartarelli, F; Tas, P; Tayalati, Y; Tegenfeldt, F; Teuscher, R; Thioye, M; Tikhomirov, V O; Timmermans, C.J.W P; Tisserant, S; Toczek, B; Tremblet, L; Troncon, C; Tsiareshka, P; Tyndel, M; Karagoz Unel, M.; Unal, G; Unel, G; Usai, G; Van Berg, R; Valero, A; Valkar, S; Valls, J A; Vandelli, W; Vannucci, F; Vartapetian, A; Vassilakopoulos, V I; Vasilyeva, L; Vazeille, F; Vernocchi, F; Vetter-Cole, Y; Vichou, I; Vinogradov, V; Virzi, J; Vivarelli, I; de Vivie, J B; Volpi, M; Vu Anh, T; Wang, C; Warren, M; Weber, J; Weber, M; Weidberg, A R; Weingarten, J; Wells, P S; Werner, P; Wheeler, S; Wiesmann, M; Wilkens, H; Williams, H H; Wingerter-Seez, I; Yasu, Y; Zaitsev, A; Zenin, A; Zenis, T; Zenonos, Z; Zhang, H; Zhelezko, A; Zhou, N

    2011-01-01

    The reconstruction of photons in the ATLAS detector is studied with data taken during the 2004 Combined Test Beam, where a full slice of the ATLAS detector was exposed to beams of particles of known energy at the CERN SPS. The results presented show significant differences in the longitudinal development of the electromagnetic shower between converted and unconverted photons as well as in the total measured energy. The potential to use the reconstructed converted photons as a means to precisely map the material of the tracker in front of the electromagnetic calorimeter is also considered. All results obtained are compared with a detailed Monte-Carlo simulation of the test-beam setup which is based on the same simulation and reconstruction tools as those used for the ATLAS detector itself.

  18. Photon reconstruction in the ATLAS Inner Detector and Liquid Argon Barrel Calorimeter at the 2004 Combined Test Beam

    Science.gov (United States)

    Abat, E.; Abdallah, J. M.; Addy, T. N.; Adragna, P.; Aharrouche, M.; Ahmad, A.; Akesson, T. P. A.; Aleksa, M.; Alexa, C.; Anderson, K.; Andreazza, A.; Anghinolfi, F.; Antonaki, A.; Arabidze, G.; Arik, E.; Atkinson, T.; Baines, J.; Baker, O. K.; Banfi, D.; Baron, S.; Barr, A. J.; Beccherle, R.; Beck, H. P.; Belhorma, B.; Bell, P. J.; Benchekroun, D.; Benjamin, D. P.; Benslama, K.; Bergeaas Kuutmann, E.; Bernabeu, J.; Bertelsen, H.; Binet, S.; Biscarat, C.; Boldea, V.; Bondarenko, V. G.; Boonekamp, M.; Bosman, M.; Bourdarios, C.; Broklova, Z.; Burckhart Chromek, D.; Bychkov, V.; Callahan, J.; Calvet, D.; Canneri, M.; Capeáns Garrido, M.; Caprini, M.; Cardiel Sas, L.; Carli, T.; Carminati, L.; Carvalho, J.; Cascella, M.; Castillo, M. V.; Catinaccio, A.; Cauz, D.; Cavalli, D.; Cavalli Sforza, M.; Cavasinni, V.; Cetin, S. A.; Chen, H.; Cherkaoui, R.; Chevalier, L.; Chevallier, F.; Chouridou, S.; Ciobotaru, M.; Citterio, M.; Clark, A.; Cleland, B.; Cobal, M.; Cogneras, E.; Conde Muino, P.; Consonni, M.; Constantinescu, S.; Cornelissen, T.; Correard, S.; Corso Radu, A.; Costa, G.; Costa, M. J.; Costanzo, D.; Cuneo, S.; Cwetanski, P.; Da Silva, D.; Dam, M.; Dameri, M.; Danielsson, H. O.; Dannheim, D.; Darbo, G.; Davidek, T.; De, K.; Defay, P. O.; Dekhissi, B.; Del Peso, J.; Del Prete, T.; Delmastro, M.; Derue, F.; Di Ciaccio, L.; Di Girolamo, B.; Dita, S.; Dittus, F.; Djama, F.; Djobava, T.; Dobos, D.; Dobson, M.; Dolgoshein, B. A.; Dotti, A.; Drake, G.; Drasal, Z.; Dressnandt, N.; Driouchi, C.; Drohan, J.; Ebenstein, W. L.; Eerola, P.; Efthymiopoulos, I.; Egorov, K.; Eifert, T. F.; Einsweiler, K.; El Kacimi, M.; Elsing, M.; Emelyanov, D.; Escobar, C.; Etienvre, A. I.; Fabich, A.; Facius, K.; Fakhr-Edine, A. I.; Fanti, M.; Farbin, A.; Farthouat, P.; Fassouliotis, D.; Fayard, L.; Febbraro, R.; Fedin, O. L.; Fenyuk, A.; Fergusson, D.; Ferrari, P.; Ferrari, R.; Ferreira, B. C.; Ferrer, A.; Ferrere, D.; Filippini, G.; Flick, T.; Fournier, D.; Francavilla, P.; Francis, D.; Froeschl, R.; Froidevaux, D.; Fullana, E.; Gadomski, S.; Gagliardi, G.; Gagnon, P.; Gallas, M.; Gallop, B. J.; Gameiro, S.; Gan, K. K.; Garcia, R.; Garcia, C.; Gavrilenko, I. L.; Gemme, C.; Gerlach, P.; Ghodbane, N.; Giakoumopoulou, V.; Giangiobbe, V.; Giokaris, N.; Glonti, G.; Goettfert, T.; Golling, T.; Gollub, N.; Gomes, A.; Gomez, M. D.; Gonzalez-Sevilla, S.; Goodrick, M. J.; Gorfine, G.; Gorini, B.; Goujdami, D.; Grahn, K.-J.; Grenier, P.; Grigalashvili, N.; Grishkevich, Y.; Grosse-Knetter, J.; Gruwe, M.; Guicheney, C.; Gupta, A.; Haeberli, C.; Haertel, R.; Hajduk, Z.; Hakobyan, H.; Hance, M.; Hansen, J. D.; Hansen, P. H.; Hara, K.; Harvey, A., Jr.; Hawkings, R. J.; Heinemann, F. E. W.; Henriques Correia, A.; Henss, T.; Hervas, L.; Higon, E.; Hill, J. C.; Hoffman, J.; Hostachy, J. Y.; Hruska, I.; Hubaut, F.; Huegging, F.; Hulsbergen, W.; Hurwitz, M.; Iconomidou-Fayard, L.; Jansen, E.; Jen-La Plante, I.; Johansson, P. D. C.; Jon-And, K.; Joos, M.; Jorgensen, S.; Joseph, J.; Kaczmarska, A.; Kado, M.; Karyukhin, A.; Kataoka, M.; Kayumov, F.; Kazarov, A.; Keener, P. T.; Kekelidze, G. D.; Kerschen, N.; Kersten, S.; Khomich, A.; Khoriauli, G.; Khramov, E.; Khristachev, A.; Khubua, J.; Kittelmann, T. H.; Klingenberg, R.; Klinkby, E. B.; Kodys, P.; Koffas, T.; Kolos, S.; Konovalov, S. P.; Konstantinidis, N.; Kopikov, S.; Korolkov, I.; Kostyukhin, V.; Kovalenko, S.; Kowalski, T. Z.; Krüger, K.; Kramarenko, V.; Kudin, L. G.; Kulchitsky, Y.; Lacasta, C.; Lafaye, R.; Laforge, B.; Lampl, W.; Lanni, F.; Laplace, S.; Lari, T.; Le Bihan, A.-C.; Lechowski, M.; Ledroit-Guillon, F.; Lehmann, G.; Leitner, R.; Lelas, D.; Lester, C. G.; Liang, Z.; Lichard, P.; Liebig, W.; Lipniacka, A.; Lokajicek, M.; Louchard, L.; Loureiro, K. F.; Lucotte, A.; Luehring, F.; Lund-Jensen, B.; Lundberg, B.; Ma, H.; Mackeprang, R.; Maio, A.; Maleev, V. P.; Malek, F.; Mandelli, L.; Maneira, J.; Mangin-Brinet, M.; Manousakis, A.; Mapelli, L.; Marques, C.; Garcia, S. Marti i.; Martin, F.; Mathes, M.; Mazzanti, M.; McFarlane, K. W.; McPherson, R.; Mchedlidze, G.; Mehlhase, S.; Meirosu, C.; Meng, Z.; Meroni, C.; Mialkovski, V.; Mikulec, B.; Milstead, D.; Minashvili, I.; Mindur, B.; Mitsou, V. A.; Moed, S.; Monnier, E.; Moorhead, G.; Morettini, P.; Morozov, S. V.; Mosidze, M.; Mouraviev, S. V.; Moyse, E. W. J.; Munar, A.; Myagkov, A.; Nadtochi, A. V.; Nakamura, K.; Nechaeva, P.; Negri, A.; Nemecek, S.; Nessi, M.; Nesterov, S. Y.; Newcomer, F. M.; Nikitine, I.; Nikolaev, K.; Nikolic-Audit, I.; Ogren, H.; Oh, S. H.; Oleshko, S. B.; Olszowska, J.; Onofre, A.; Padilla Aranda, C.; Paganis, S.; Pallin, D.; Pantea, D.; Paolone, V.; Parodi, F.; Parsons, J.; Parzhitskiy, S.; Pasqualucci, E.; Passmored, S. M.; Pater, J.; Patrichev, S.; Peez, M.; Perez Reale, V.; Perini, L.; Peshekhonov, V. D.; Petersen, J.; Petersen, T. C.; Petti, R.; Phillips, P. W.; Pilcher, J.; Pina, J.; Pinto, B.; Podlyski, F.; Poggioli, L.; Poppleton, A.; Poveda, J.; Pralavorio, P.; Pribyl, L.; Price, M. J.; Prieur, D.; Puigdengoles, C.; Puzo, P.; Ragusa, F.; Rajagopalan, S.; Reeves, K.; Reisinger, I.; Rembser, C.; Bruckman de Renstrom, P. A.; Reznicek, P.; Ridel, M.; Risso, P.; Riu, I.; Robinson, D.; Roda, C.; Roe, S.; Røhne, O.; Romaniouk, A.; Rousseau, D.; Rozanov, A.; Ruiz, A.; Rusakovich, N.; Rust, D.; Ryabov, Y. F.; Ryjov, V.; Salto, O.; Salvachua, B.; Salzburger, A.; Sandaker, H.; Santamarina Rios, C.; Santi, L.; Santoni, C.; Saraiva, J. G.; Sarri, F.; Sauvage, G.; Says, L. P.; Schaefer, M.; Schegelsky, V. A.; Schiavi, C.; Schieck, J.; Schlager, G.; Schlereth, J.; Schmitt, C.; Schultes, J.; Schwemling, P.; Schwindling, J.; Seixas, J. M.; Seliverstov, D. M.; Serin, L.; Sfyrla, A.; Shalanda, N.; Shaw, C.; Shin, T.; Shmeleva, A.; Silva, J.; Simion, S.; Simonyan, M.; Sloper, J. E.; Smirnov, S. Yu; Smirnova, L.; Solans, C.; Solodkov, A.; Solovianov, O.; Soloviev, I.; Sosnovtsev, V. V.; Spanò, F.; Speckmayer, P.; Stancu, S.; Stanek, R.; Starchenko, E.; Straessner, A.; Suchkov, S. I.; Suk, M.; Szczygiel, R.; Tarrade, F.; Tartarelli, F.; Tas, P.; Tayalati, Y.; Tegenfeldt, F.; Teuscher, R.; Thioye, M.; Tikhomirov, V. O.; Timmermans, C. J. W. P.; Tisserant, S.; Toczek, B.; Tremblet, L.; Troncon, C.; Tsiareshka, P.; Tyndel, M.; Karagoez Unel, M.; Unal, G.; Unel, G.; Usai, G.; Van Berg, R.; Valero, A.; Valkar, S.; Valls, J. A.; Vandelli, W.; Vannucci, F.; Vartapetian, A.; Vassilakopoulos, V. I.; Vasilyeva, L.; Vazeille, F.; Vernocchi, F.; Vetter-Cole, Y.; Vichou, I.; Vinogradov, V.; Virzi, J.; Vivarelli, I.; de Vivie, J. B.; Volpi, M.; Anh, T. Vu; Wang, C.; Warren, M.; Weber, J.; Weber, M.; Weidberg, A. R.; Weingarten, J.; Wells, P. S.; Werner, P.; Wheeler, S.; Wiessmann, M.; Wilkens, H.; Williams, H. H.; Wingerter-Seez, I.; Yasu, Y.; Zaitsev, A.; Zenin, A.; Zenis, T.; Zenonos, Z.; Zhang, H.; Zhelezko, A.; Zhou, N.

    2011-04-01

    The reconstruction of photons in the ATLAS detector is studied with data taken during the 2004 Combined Test Beam, where a full slice of the ATLAS detector was exposed to beams of particles of known energy at the CERN SPS. The results presented show significant differences in the longitudinal development of the electromagnetic shower between converted and unconverted photons as well as in the total measured energy. The potential to use the reconstructed converted photons as a means to precisely map the material of the tracker in front of the electromagnetic calorimeter is also considered. All results obtained are compared with a detailed Monte-Carlo simulation of the test-beam setup which is based on the same simulation and reconstruction tools as those used for the ATLAS detector itself.

  19. Combined hydrogen and lithium beam emission spectroscopy observation system for Korea Superconducting Tokamak Advanced Research

    Energy Technology Data Exchange (ETDEWEB)

    Lampert, M. [Wigner RCP, Euratom Association-HAS, Budapest (Hungary); BME NTI, Budapest (Hungary); Anda, G.; Réfy, D.; Zoletnik, S. [Wigner RCP, Euratom Association-HAS, Budapest (Hungary); Czopf, A.; Erdei, G. [Department of Atomic Physics, BME IOP, Budapest (Hungary); Guszejnov, D.; Kovácsik, Á.; Pokol, G. I. [BME NTI, Budapest (Hungary); Nam, Y. U. [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2015-07-15

    A novel beam emission spectroscopy observation system was designed, built, and installed onto the Korea Superconducting Tokamak Advanced Research tokamak. The system is designed in a way to be capable of measuring beam emission either from a heating deuterium or from a diagnostic lithium beam. The two beams have somewhat complementary capabilities: edge density profile and turbulence measurement with the lithium beam and two dimensional turbulence measurement with the heating beam. Two detectors can be used in parallel: a CMOS camera provides overview of the scene and lithium beam light intensity distribution at maximum few hundred Hz frame rate, while a 4 × 16 pixel avalanche photo-diode (APD) camera gives 500 kHz bandwidth data from a 4 cm × 16 cm region. The optics use direct imaging through lenses and mirrors from the observation window to the detectors, thus avoid the use of costly and inflexible fiber guides. Remotely controlled mechanisms allow adjustment of the APD camera’s measurement location on a shot-to-shot basis, while temperature stabilized filter holders provide selection of either the Doppler shifted deuterium alpha or lithium resonance line. The capabilities of the system are illustrated by measurements of basic plasma turbulence properties.

  20. Dynamic Finite Element Analysis of Bending-Torsion Coupled Beams Subjected to Combined Axial Load and End Moment

    Directory of Open Access Journals (Sweden)

    Mir Tahmaseb Kashani

    2015-01-01

    Full Text Available The dynamic analysis of prestressed, bending-torsion coupled beams is revisited. The axially loaded beam is assumed to be slender, isotropic, homogeneous, and linearly elastic, exhibiting coupled flexural-torsional displacement caused by the end moment. Based on the Euler-Bernoulli bending and St. Venant torsion beam theories, the vibration and stability of such beams are explored. Using the closed-form solutions of the uncoupled portions of the governing equations as the basis functions of approximation space, the dynamic, frequency-dependent, interpolation functions are developed, which are then used in conjunction with the weighted residual method to develop the Dynamic Finite Element (DFE of the system. Having implemented the DFE in a MATLAB-based code, the resulting nonlinear eigenvalue problem is then solved to determine the coupled natural frequencies of illustrative beam examples, subjected to various boundary and load conditions. The proposed method is validated against limited available experimental and analytical data, those obtained from an in-house conventional Finite Element Method (FEM code and FEM-based commercial software (ANSYS. In comparison with FEM, the DFE exhibits higher convergence rates and in the absence of end moment it produces exact results. Buckling analysis is also carried out to determine the critical end moment and compressive force for various load combinations.

  1. Deflection and Supporting Force Analysis of a Slender Beam under Combined Transverse and Tensile Axial Loads

    Science.gov (United States)

    2016-05-01

    testing, digital filtering of flight test data , nonlinear optimisation, and spectral analysis. His recent work has been in the areas of structural shape...formula [2]: = 4 8 (26) 3.3 Nonlinear FEA solution for tension force T ≥ 0 case The Abaqus 6.14-2 finite element analysis code...accurately determine the peak deflection and its location along the span of the beam. The Abaqus beam element type B23 was used, which corresponds to a 2

  2. Combining Coherent Hard X-Ray Tomographies with Phase Retrieval to Generate Three-Dimensional Models of Forming Bone

    Directory of Open Access Journals (Sweden)

    Emely L. Bortel

    2017-11-01

    Full Text Available Holotomography, a phase-sensitive synchrotron-based (µCT modality, is a quantitative 3D imaging method. By exploiting partial spatial X-ray coherence, bones can be imaged volumetrically with high resolution coupled with impressive density sensitivity. This tomographic method reveals the main characteristics of the important tissue compartments in forming bones, including the rapidly changing soft tissue and the partially or fully mineralized bone regions, while revealing subtle density differences in 3D. Here, we show typical results observed within the growing femur bone midshafts of healthy mice that are 1, 3, 7, 10, and 14 days old (postpartum. Our results make use of partially coherent synchrotron radiation employing inline Fresnel propagation in multiple tomographic datasets obtained in the imaging beamline ID19 of the European Synchrotron Radiation Facility. The exquisite detail creates maps of the juxtaposed soft, partially mineralized and highly mineralized bone revealing the environment in which bone cells create and shape the matrix. This high-resolution 3D data can be used to create detailed computational models to study the dynamic processes involved in bone tissue formation and adaptation. Such data can enhance our understanding of the important biomechanical interactions directing maturation and shaping of the bone micro- and macro-geometries.

  3. Interference due to coherence swapping

    Indian Academy of Sciences (India)

    pinhole arrangement in a diaphragm behind the crystal and/or with the use of filters. 4.2 Proposed observation of coherence swapping. We take two separate down conversion crystals, A, B, however pumped by the same pulsed laser (see figure 2). The pump beam is beam-split in such a way that the pulses enter both. 398.

  4. Coherence effects in Mie scattering

    NARCIS (Netherlands)

    Fischer, D.G.; van Dijk, T.; Visser, T.D.; Wolf, E.

    2012-01-01

    The scattering of a partially coherent beam by a deterministic, spherical scatterer is studied. In particular, the Mie scattering by a Gaussian Schell-model beam is analyzed. Expressions are derived for (a) the extinguished power, (b) the radiant intensity of the scattered field, and (c) the

  5. Treatment of keloid in upper limb by combined surgical excision and immediate postoperative electron beam irradiation

    International Nuclear Information System (INIS)

    Shimada, Kenichi; Yoshida, Jun; Heshiki, Takaya; Ishikura, Naotaka; Kawakami, Shigehiko

    2002-01-01

    A scar in the upper extremities sometimes leads to onset of keloid, whose treatment is difficult and many treatment methods have been tried. Recently our hospital has performed electron beam radiation for treatment of keloid. In this report, we describe our examination on patients with keloid in the upper extremities who visited our hospital and underwent electron beam irradiation in these past 7 years. The patients were 9 males and 15 females, age between 9 and 84 (average age 26.6 years). Treatments included the following: Total ablation of keloid plus electron beam radiation, electron beam radiation alone, localized administration of triamcinolone. Treatment evaluation and presence or absence of pigmentation was examined. Electron beam radiation was performed with a total of 25 Gy for consecutive 5 days by 5 Gy electron beam since 1 week after keloid ablation with sufficient informed consent. Onset site of 24 patients with keloid in the upper extremities was the shoulder in 12 patients, the upper arm in 11, and the elbow in one patient. Development cause was BCG inoculation in 8 patients, wound associated with surgery in 6, unknown cause in 6, and others in 4 patients. The number of patients who were followed-up after treatment was 16 for each examination respectively, and mean followed-up period was 2 years and 10 months. Postoperative evaluation for ablation plus electron beam was good in 1 patient and fair in 6, that for electron beam radiation alone was good in 1, fair in 2, and unknown in 2, and that for triamcinolone was fair in 2, poor in 4, and unknown in 1 patient. Postoperative pigmentation was observed in all the patients immediately after radiation, and at the time of final follow-up, in 6 (33%) out of 9 patients confirmed. Ablation plus electron beam irradiation for keloid in the upper extremities was effective. However, this treatment cannot avoid a possibility of cancerogenesis. Thus, sufficient explanation and consent may be essential after full

  6. Optical microscope using an interferometric source of two-color, two-beam entangled photons

    Science.gov (United States)

    Dress, William B.; Kisner, Roger A.; Richards, Roger K.

    2004-07-13

    Systems and methods are described for an optical microscope using an interferometric source of multi-color, multi-beam entangled photons. A method includes: downconverting a beam of coherent energy to provide a beam of multi-color entangled photons; converging two spatially resolved portions of the beam of multi-color entangled photons into a converged multi-color entangled photon beam; transforming at least a portion of the converged multi-color entangled photon beam by interaction with a sample to generate an entangled photon specimen beam; and combining the entangled photon specimen beam with an entangled photon reference beam within a single beamsplitter. An apparatus includes: a multi-refringent device providing a beam of multi-color entangled photons; a condenser device optically coupled to the multi-refringent device, the condenser device converging two spatially resolved portions of the beam of multi-color entangled photons into a converged multi-color entangled photon beam; a beam probe director and specimen assembly optically coupled to the condenser device; and a beam splitter optically coupled to the beam probe director and specimen assembly, the beam splitter combining an entangled photon specimen beam from the beam probe director and specimen assembly with an entangled photon reference beam.

  7. Combining deep learning and coherent anti-Stokes Raman scattering imaging for automated differential diagnosis of lung cancer

    Science.gov (United States)

    Weng, Sheng; Xu, Xiaoyun; Li, Jiasong; Wong, Stephen T. C.

    2017-10-01

    Lung cancer is the most prevalent type of cancer and the leading cause of cancer-related deaths worldwide. Coherent anti-Stokes Raman scattering (CARS) is capable of providing cellular-level images and resolving pathologically related features on human lung tissues. However, conventional means of analyzing CARS images requires extensive image processing, feature engineering, and human intervention. This study demonstrates the feasibility of applying a deep learning algorithm to automatically differentiate normal and cancerous lung tissue images acquired by CARS. We leverage the features learned by pretrained deep neural networks and retrain the model using CARS images as the input. We achieve 89.2% accuracy in classifying normal, small-cell carcinoma, adenocarcinoma, and squamous cell carcinoma lung images. This computational method is a step toward on-the-spot diagnosis of lung cancer and can be further strengthened by the efforts aimed at miniaturizing the CARS technique for fiber-based microendoscopic imaging.

  8. Compact multiple laser beam scanning module for high-resolution pico-projector applications using a fiber bundle combiner

    Science.gov (United States)

    Ide, Masafumi; Fukaya, Shinpei; Yoda, Kaoru; Suzuki, Masaya

    2014-02-01

    We present a novel multiple laser beam scanning projection module using compact red-green-blue (RGB) fiber pigtailed laser modules for use in a high resolution pico-projector display system using a fiber bundle combiner in combination with a single MEMS mirror. This system can be used to create accurate multiple-projection images on a screen without overlaps or spaces among the projection images. The system uses very simple projection optics and has the potential to become a light engine unit for use in multiple projection systems, particularly those for light field displays. As such, light field display applications are also discussed.

  9. Coherence effects in Mie scattering.

    Science.gov (United States)

    Fischer, David G; van Dijk, Thomas; Visser, Taco D; Wolf, Emil

    2012-01-01

    The scattering of a partially coherent beam by a deterministic, spherical scatterer is studied. In particular, the Mie scattering by a Gaussian Schell-model beam is analyzed. Expressions are derived for (a) the extinguished power, (b) the radiant intensity of the scattered field, and (c) the encircled energy in the far field. It is found that the radiant intensity and the encircled energy in the far field depend on the degree of coherence of the incident beam, whereas the extinguished power does not.

  10. Ion-optical studies for a range adaptation method in ion beam therapy using a static wedge degrader combined with magnetic beam deflection

    International Nuclear Information System (INIS)

    Chaudhri, Naved; Saito, Nami; Bert, Christoph; Franczak, Bernhard; Steidl, Peter; Durante, Marco; Schardt, Dieter; Rietzel, Eike

    2010-01-01

    Fast radiological range adaptation of the ion beam is essential when target motion is mitigated by beam tracking using scanned ion beams for dose delivery. Electromagnetically controlled deflection of a well-focused ion beam on a small static wedge degrader positioned between two dipole magnets, inside the beam delivery system, has been considered as a fast range adaptation method. The principle of the range adaptation method was tested in experiments and Monte Carlo simulations for the therapy beam line at the GSI Helmholtz Centre for Heavy Ions Research. Based on the simulations, ion optical settings of beam deflection and realignment of the adapted beam were experimentally applied to the beam line, and additional tuning was manually performed. Different degrader shapes were employed for the energy adaptation. Measured and simulated beam profiles, i.e. lateral distribution and range in water at isocentre, were analysed and compared with the therapy beam values for beam scanning. Deflected beam positions of up to ±28 mm on degrader were performed which resulted in a range adaptation of up to ±15 mm water equivalence (WE). The maximum deviation between the measured adapted range from the nominal range adaptation was below 0.4 mm WE. In experiments, the width of the adapted beam at the isocentre was adjustable between 5 and 11 mm full width at half maximum. The results demonstrate the feasibility/proof of the proposed range adaptation method for beam tracking from the beam quality point of view.

  11. Ion-optical studies for a range adaptation method in ion beam therapy using a static wedge degrader combined with magnetic beam deflection

    Science.gov (United States)

    Chaudhri, Naved; Saito, Nami; Bert, Christoph; Franczak, Bernhard; Steidl, Peter; Durante, Marco; Rietzel, Eike; Schardt, Dieter

    2010-06-01

    Fast radiological range adaptation of the ion beam is essential when target motion is mitigated by beam tracking using scanned ion beams for dose delivery. Electromagnetically controlled deflection of a well-focused ion beam on a small static wedge degrader positioned between two dipole magnets, inside the beam delivery system, has been considered as a fast range adaptation method. The principle of the range adaptation method was tested in experiments and Monte Carlo simulations for the therapy beam line at the GSI Helmholtz Centre for Heavy Ions Research. Based on the simulations, ion optical settings of beam deflection and realignment of the adapted beam were experimentally applied to the beam line, and additional tuning was manually performed. Different degrader shapes were employed for the energy adaptation. Measured and simulated beam profiles, i.e. lateral distribution and range in water at isocentre, were analysed and compared with the therapy beam values for beam scanning. Deflected beam positions of up to ±28 mm on degrader were performed which resulted in a range adaptation of up to ±15 mm water equivalence (WE). The maximum deviation between the measured adapted range from the nominal range adaptation was below 0.4 mm WE. In experiments, the width of the adapted beam at the isocentre was adjustable between 5 and 11 mm full width at half maximum. The results demonstrate the feasibility/proof of the proposed range adaptation method for beam tracking from the beam quality point of view.

  12. Effects of the beam loading in the rf deflectors of the CLIC test facility CTF3 combiner ring

    Directory of Open Access Journals (Sweden)

    David Alesini

    2004-04-01

    Full Text Available In this paper we study the impact of the rf deflectors beam loading on the transverse beam dynamics of the CTF3 combiner ring. A general expression for the single-passage wake field is obtained. Different approximated formulas are derived applying linearization of the rf deflector dispersion curve either on a limited or an unlimited frequency range. A dedicated tracking code has been written to study the multibunch multiturn effects on the transverse beam dynamics. The numerical simulations reveal that the beam emittance growth due to the wake field in the rf deflectors is a small fraction of the design emittance if the trains are injected perfectly on axis. Nevertheless in case of injection errors the final emittance growth strongly depends on the betatron phase advance between the rf deflectors. If the finite bunch length is included in the tracking code, the scenario for the central part of the bunches does not change. However, for some particular injection errors, the tails of the bunches can increase the total transverse bunch emittances.

  13. Dynamics of combined electron beam and laser dispersion of polymers in vacuum

    OpenAIRE

    Luchnikov, P. A.; Rogachev, A. V.; Yarmolenko, M. A.; Rogachev, A. A.; Bespalko (Bespal'ko), Anatoly Alekseevich

    2016-01-01

    The mechanisms of the impact of the laser assisting effect on the dispersion kinetics and on the structure of the deposited layers in electron beam dispersion of a polymer target were analyzed. The proposed model and analytical expressions adequately describe the kinetic dependence of the polymer materials dispersion rate in a vacuum on the intensity of laser processing of their dispersion zone.

  14. Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration

    Science.gov (United States)

    Wei, David Wei; Deegan, Anthony J.; Wang, Ruikang K.

    2017-06-01

    When using optical coherence tomography angiography (OCTA), the development of artifacts due to involuntary movements can severely compromise the visualization and subsequent quantitation of tissue microvasculatures. To correct such an occurrence, we propose a motion compensation method to eliminate artifacts from human skin OCTA by means of step-by-step rigid affine registration, rigid subpixel registration, and nonrigid B-spline registration. To accommodate this remedial process, OCTA is conducted using two matching all-depth volume scans. Affine transformation is first performed on the large vessels of the deep reticular dermis, and then the resulting affine parameters are applied to all-depth vasculatures with a further subpixel registration to refine the alignment between superficial smaller vessels. Finally, the coregistration of both volumes is carried out to result in the final artifact-free composite image via an algorithm based upon cubic B-spline free-form deformation. We demonstrate that the proposed method can provide a considerable improvement to the final en face OCTA images with substantial artifact removal. In addition, the correlation coefficients and peak signal-to-noise ratios of the corrected images are evaluated and compared with those of the original images, further validating the effectiveness of the proposed method. We expect that the proposed method can be useful in improving qualitative and quantitative assessment of the OCTA images of scanned tissue beds.

  15. A Layer Correlation Technique for Pion Energy Calibration at the 2004 ATLAS Combined Beam Test (Conference record)

    CERN Document Server

    Grahn, K-J; The ATLAS collaboration

    2009-01-01

    A new method for calibrating the hadron response of a segmented calorimeter is developed. It is based on a principal component analysis of the calorimeter layer energy deposits, exploiting longitudinal shower development information to improve the measured energy resolution. Corrections for invisible hadronic energy and energy lost in dead material in front of and between the ATLAS calorimeters were calculated with simulated Geant4 Monte Carlo events and used to reconstruct the energy of pions impinging on the calorimeters during the 2004 Barrel Combined Beam Test at the CERN H8 area. For pion beams with energies between 20 and 180 GeV, the particle energy is reconstructed within 3% and the energy resolution is improved by about 20% compared to the electromagnetic scale.

  16. Respiratory gated beam delivery cannot facilitate margin reduction, unless combined with respiratory correlated image guidance

    DEFF Research Database (Denmark)

    Korreman, S.S.; Boyer, A.L.; Juhler-Nøttrup, Trine

    2008-01-01

    PURPOSE/OBJECTIVE: In radiotherapy of targets moving with respiration, beam gating is offered as a means of reducing the target motion. The purpose of this study is to evaluate the safe magnitude of margin reduction for respiratory gated beam delivery. MATERIALS/METHODS: The study is based on data...... for 17 lung cancer patients in separate protocols at Rigshospitalet and Stanford Cancer Center. Respiratory curves for external optical markers and implanted fiducials were collected using equipment based on the RPM system (Varian Medical Systems). A total of 861 respiratory curves represented external...... measurements over 30 fraction treatment courses for 10 patients, and synchronous external/internal measurements in single sessions for seven patients. Variations in respiratory amplitude (simulated coaching) and external/internal phase shifts were simulated by perturbation with realistic values. Variations...

  17. LISE 3: a magnetic spectrometer—Wien filter combination for secondary radioactive beam production

    Science.gov (United States)

    Anne, Remy; Mueller, Alex C.

    1992-08-01

    The doubly achromatic spectrometer LISE installed at GANIL has been running since six years for the study of exotic nuclei and the production of secondary beams obtained by the interaction of high energy heavy ions ( E/ A 30). ii) A velocity filter based on an electrostatic field crossed with a magnetic one has been installed. This filter provides a third selection which is powerful in suppressing contaminants. Furthermore, the flight path between the target and the final focus is now increased to 43 m, which allows easy time-of-flight measurements also for heavy species. LISE 3 provides separated secondary beams of increased intensity and isotopic purity. We shall review the essential properties and present some recent experimental results for illustration.

  18. Investigation of the combined effect of neutron irradiation and electron beam exposure on pure tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Van Renterghem, W., E-mail: wvrenter@sckcen.be; Uytdenhouwen, I., E-mail: iuytdenh@sckcen.be

    2016-08-15

    Pure tungsten samples were neutron irradiated in the BR2 reactor of SCK·CEN to fluences of 1.47 × 10{sup 20} n/cm{sup 2} and 4.74 × 10{sup 20} n/cm{sup 2} at 300 °C under Helium atmosphere and exposed to the electron beam of the Judith 1 installation The effect of these treatments on the defect structure was studied with transmission electron microscopy. In the irradiated samples the defect structure in the bulk is compared to the structure at the surface. The neutron irradiation created a large amount of a/2‹111› type dislocation loops forming dislocation rafts. The loop density increased from 8.5 × 10{sup 21}/m³ to 9 × 10{sup 22}/m³ with increasing dose, while the loop size decreased from 5.2 nm to 3.5 nm. The electron beam exposure induced significant annealing of the defects and almost all of the dislocation loops were removed. The number of line dislocations in that area increased as a result of the thermal stresses from the thermal shock. - Highlights: • Neutron irradiated and electron beam exposed tungsten samples were studied with transmission electron microscopy. • Neutron irradiation creates dislocation loops and rafts, while voids are created at higher irradiation dose. • No precipitates of transmutation products were found under these low dose irradiation conditions. • Electron beam exposure annihilates the dislocation loops and rafts.

  19. Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement

    Science.gov (United States)

    Wang, Shang; Li, Jiasong; Vantipalli, Srilatha; Manapuram, Ravi Kiran; Ingram, Davis R.; Twa, Michael D.; Lazar, Alexander J.; Lev, Dina C.; Pollock, Raphael E.; Larin, Kirill V.

    2013-03-01

    We combine a focused air-puff system with phase-sensitive optical coherence tomography (PhS-OCT) to measure the elasticity of soft tissues. Surface waves (SWs) on soft tissues are induced by a low-pressure, short-duration air stream from an air-puff system and measured using a high-sensitivity PhS-OCT imaging system. Young's modulus of soft tissues can be quantified based on the group velocity of SWs. To precisely control the excitation pressure, the air-puff system was characterized with a high-resolution analog pressure transducer. We studied the feasibility of this method for the non-contact detection of soft-tissue tumors. Ex vivo human fat and myxoma were used for these pilot experiments. Results demonstrate that this optical non-contact technique can be used to differentiate soft-tissue tumors from normal tissues based on measurements of their elasticity.

  20. High Charge PHIN Photo Injector at CERN with Fast Phase switching within the Bunch Train for Beam Combination

    CERN Document Server

    Csatari Divall, M; Bolzon, B; Bravin, E; Chevallay, E; Dabrowski, A; Doebert, S; Drozdy, A; Fedosseev, V; Hessler, C; Lefevre, T; Livesley, S; Losito, R; Olvegaard, M; Petrarca, M; Rabiller, A N; Egger, D; Mete, O

    2011-01-01

    The high charge PHIN photo-injector was developed within the framework of the European CARE program to provide an alternative to the drive beam thermionic gun in the CTF3 (CLIC Test Facility) at CERN. In PHIN 1908 electron bunches are delivered with bunch spacing of 1.5 GHz and 2.33 nC charge per bunch. Furthermore the drive beam generated by CTF3 requires several fast 180 deg phase-shifts with respect to the 1.5 GHz bunch repetition frequency in order to allow the beam combination scheme developed at CTF3. A total of 8 subtrains, each 140 ns long and shifted in phase with respect to each other, have to be produced with very high phase and amplitude stability. A novel fiber modulator based phase-switching technique developed on the laser system provides this phase-shift between two consecutive pulses much faster and cleaner than the base line scheme, where a thermionic electron gun and sub-harmonic bunching are used. The paper describes the fiber-based switching system and the measurements verifying the schem...

  1. X-ray interferometry with transmissive beam combiners for ultra-high angular resolution astronomy

    OpenAIRE

    Skinner, G. K.; Krizmanic, J. F.

    2009-01-01

    Interferometry provides one of the possible routes to ultra-high angular resolution for X-ray and gamma-ray astronomy. Sub-micro-arc-second angular resolution, necessary to achieve objectives such as imaging the regions around the event horizon of a super-massive black hole at the center of an active galaxy, can be achieved if beams from parts of the incoming wavefront separated by 100s of meters can be stably and accurately brought together at small angles. One way of achieving this is by us...

  2. Coherence, Complexity and Creativity

    Science.gov (United States)

    Arecchi, Fortunato Tito

    We review the ideas and experiments that established the onset of laser coherence beyond a suitable threshold. That threshold is the first of a chain of bifurcations in a non linear dynamics, leading eventually to deterministic chaos in lasers. In particular, the so called HC behavior has striking analogies with the electrical activity of neurons. Based on these considerations, we develop a dynamical model of neuron synchronization leading to coherent global perceptions. Synchronization implies a transitory control of neuron chaos. Depending on the time duration of this control, a cognitive agent has different amounts of awareness. Combining this with a stream of external inputs, one can point at an optimal use of internal resources, that is called cognitive creativity. While coherence is associated with long range correlations, complexity arises whenever an array of coupled dynamical systems displays multiple paths of coherence. What is the relation among the three concepts in the title? While coherence is associated with long range correlations, complexity arises whenever an array of coupled dynamical systems displays multiple paths of coherence. Creativity corresponds to a free selection of a coherence path within a complex nest. As sketched above, it seems dynamically related to chaos control.

  3. Enhanced delegated computing using coherence

    Science.gov (United States)

    Barz, Stefanie; Dunjko, Vedran; Schlederer, Florian; Moore, Merritt; Kashefi, Elham; Walmsley, Ian A.

    2016-03-01

    A longstanding question is whether it is possible to delegate computational tasks securely—such that neither the computation nor the data is revealed to the server. Recently, both a classical and a quantum solution to this problem were found [C. Gentry, in Proceedings of the 41st Annual ACM Symposium on the Theory of Computing (Association for Computing Machinery, New York, 2009), pp. 167-178; A. Broadbent, J. Fitzsimons, and E. Kashefi, in Proceedings of the 50th Annual Symposium on Foundations of Computer Science (IEEE Computer Society, Los Alamitos, CA, 2009), pp. 517-526]. Here, we study the first step towards the interplay between classical and quantum approaches and show how coherence can be used as a tool for secure delegated classical computation. We show that a client with limited computational capacity—restricted to an XOR gate—can perform universal classical computation by manipulating information carriers that may occupy superpositions of two states. Using single photonic qubits or coherent light, we experimentally implement secure delegated classical computations between an independent client and a server, which are installed in two different laboratories and separated by 50 m . The server has access to the light sources and measurement devices, whereas the client may use only a restricted set of passive optical devices to manipulate the information-carrying light beams. Thus, our work highlights how minimal quantum and classical resources can be combined and exploited for classical computing.

  4. Influence of external beam technique and brachytherapy quality assurance on the side effects in the combined external beam- and brachytherapy treatment of local advanced prostate cancer

    International Nuclear Information System (INIS)

    Kovacs, G.; Galalae, R.; Wirth, B.; Bertermann, H.; Wilhelm, R.; Kohr, P.; Kimmig, B.

    1996-01-01

    Transrectal ultrasound(TRUS) guided HDR implantation of the prostate has been established at the Kiel University by Bertermann and Brix in 1986 and there are to date 179 (T1b-T3 No Mo) patients treated in a combined modality. The dose for the implant was 2x 15 Gy on the capsule of the prostate in 14-20 days. For local and regional lymph nodes 20 Gy external beam therapy (AP-PA pelvic portals), 20 Gy with an individual transmission block (100% for subclinical disease, 70% and 50% according to the implant dosimetry for the prostate) and 10 Gy small volume irradiation for the prostate was applied, conventional fractioned. Total dose after the therapy 70 Gy for the prostate and 50 Gy for the subclinical disease in 6-7 weeks. As a quality control method we use since 1991 in vivo dosimetry on the medial rectum wall as well as in the prostatic part of the urethra. Regular follow-up 3-118 months after therapy (median 55) with PSA, digital rectal examination, control TRUS with volumetry (after one year with biopsy) and bone scan. There were no major early side effects within the first three months. Proctitis till 1991 with a duration up to 12 months 49%, prolonging more than one year in 23 %, (total proctitis 72.6%). Dysuria in up to 12 months 30 %, long lasting 30% (total number of dysuria 60 %). Erectile dysfunction in 56 %. Because of the number of the side effects 1991 we changed the external beam technique: instead of the biaxial arch therapy the AP-PA portals, and reduced irradiated volume (from 6480 cm 3 to 5040 cm 3 ). We introduced instead of the small volume arch therapy for 10 Gy external boost the box-technique with shielding the back part of the rectum and the upper part of the bladder resulting additional volume reduction. Through the 15 Gy HDR brachytherapy dose on the prostate capsule there are up to 8 Gy on the medial rectal wall, measured by in vivo dosimetry. This dose could not be responsible for the high number of side effects (see gynecological

  5. Experimental study on partial coherence source

    CERN Document Server

    Zhao Xue Qing; Yuan Xiao; LiuJingRu; Wang Long Hua; Tang Ying; Huang, Kerson

    2002-01-01

    Partial coherence source is a key part in the laser system using echelon-free introduced spatial incoherence beam smoothing technique. Different kinds of partial coherence sources have been studied experimentally for improving the uniformity of laser intensity distribution. It is found that the source produced by excimer laser scattering on the surface of a teflon plate is ideal. The properties of this kind of source are studied. As a result, the uniformity of source beam intensity distribution, the beam spatial coherence and energy transfer efficiency of the source are obtained

  6. Respiratory gated beam delivery cannot facilitate margin reduction, unless combined with respiratory correlated image guidance

    International Nuclear Information System (INIS)

    Korreman, Stine S.; Juhler-Nottrup, Trine; Boyer, Arthur L.

    2008-01-01

    Purpose/objective: In radiotherapy of targets moving with respiration, beam gating is offered as a means of reducing the target motion. The purpose of this study is to evaluate the safe magnitude of margin reduction for respiratory gated beam delivery. Materials/methods: The study is based on data for 17 lung cancer patients in separate protocols at Rigshospitalet and Stanford Cancer Center. Respiratory curves for external optical markers and implanted fiducials were collected using equipment based on the RPM system (Varian Medical Systems). A total of 861 respiratory curves represented external measurements over 30 fraction treatment courses for 10 patients, and synchronous external/internal measurements in single sessions for seven patients. Variations in respiratory amplitude (simulated coaching) and external/internal phase shifts were simulated by perturbation with realistic values. Variations were described by medians and standard deviations (SDs) of position distributions of the markers. Gating windows (35% duty cycle) were retrospectively applied to the respiratory data for each session, mimicking the use of commercially available gating systems. Medians and SDs of gated data were compared to those of ungated data, to assess potential margin reductions. Results: External respiratory data collected over entire treatment courses showed SDs from 1.6 to 8.1 mm, the major part arising from baseline variations. The gated data had SDs from 1.5 to 7.7 mm, with a mean reduction of 0.3 mm (6%). Gated distributions were more skewed than ungated, and in a few cases a marginal miss of gated respiration would be found even if no margin reduction was applied. Regularization of breathing amplitude to simulate coaching did not alter these results significantly. Simulation of varying phase shifts between internal and external respiratory signals showed that the SDs of gated distributions were the same as for the ungated or smaller, but the median values were markedly shifted

  7. Coherent betatron instability in the Tevatron

    International Nuclear Information System (INIS)

    Bogacz, S.A.; Harrison, M.; Ng, K.Y.

    1988-01-01

    The coherent betatron instability was first observed during the recent 1987-88 Tevatron fixed target run. In this operating mode 1000 consecutive bunches are loaded into the machine at 150 GeV with a bunch spacing of 18.8 /times/ 10 -9 sec (53 MHz). The normalized transverse emittance is typically 15 π /times/ 10 -6 m rad in each plane with a longitudinal emittance of about 1.5 eV-sec. The beam is accelerated to 800 GeV in 13 sec. and then it is resonantly extracted during a 23 sec flat top. As the run progressed the bunch intensities were increased until at about 1.4 /times/ 10 10 ppb (protons per bunch) we experienced the onset of a coherent horizontal oscillation taking place in the later stages of the acceleration cycle (>600 GeV). This rapidly developing coherent instability results in a significant emittance growth, which limits machine performance and in a catastrophic scenario it even prevents extraction of the beam. In this paper we will present a simple analytic description of the observed instability. We will show that a combination of a resistive wall coupled bunch effect and a single bunch slow head-tail instability is consistent with the above observations. Finally, a systematic numerical analysis of our model (growth-time vs chromaticity plots) points to the existence of the ≥1 slow head-tail modes as a plausible mechanism for the observed coherent instability. This last claim, as mentioned before, does not have conclusive experimental evidence, although it is based on a very good agreement between the measured values of the instability growth-time and the ones calculated on the basis of our model. 4 refs., 3 figs

  8. Silicon-based photonic crystals fabricated using proton beam writing combined with electrochemical etching method.

    Science.gov (United States)

    Dang, Zhiya; Breese, Mark Bh; Recio-Sánchez, Gonzalo; Azimi, Sara; Song, Jiao; Liang, Haidong; Banas, Agnieszka; Torres-Costa, Vicente; Martín-Palma, Raúl José

    2012-07-23

    A method for fabrication of three-dimensional (3D) silicon nanostructures based on selective formation of porous silicon using ion beam irradiation of bulk p-type silicon followed by electrochemical etching is shown. It opens a route towards the fabrication of two-dimensional (2D) and 3D silicon-based photonic crystals with high flexibility and industrial compatibility. In this work, we present the fabrication of 2D photonic lattice and photonic slab structures and propose a process for the fabrication of 3D woodpile photonic crystals based on this approach. Simulated results of photonic band structures for the fabricated 2D photonic crystals show the presence of TE or TM gap in mid-infrared range.

  9. Respiratory gated beam delivery cannot facilitate margin reduction, unless combined with respiratory correlated image guidance

    DEFF Research Database (Denmark)

    Korreman, S.S.; Boyer, A.L.; Juhler-Nøttrup, Trine

    2008-01-01

    was not accounted for. CONCLUSIONS: Margins can only be reduced for respiratory gated radiotherapy, if respiratory baseline shifts and variations in external/internal motion correlation are accounted for. Gated beam delivery alone cannot facilitate margin reduction. In the worst case, margins must be increased...... measurements over 30 fraction treatment courses for 10 patients, and synchronous external/internal measurements in single sessions for seven patients. Variations in respiratory amplitude (simulated coaching) and external/internal phase shifts were simulated by perturbation with realistic values. Variations...... compared to those of ungated data, to assess potential margin reductions. RESULTS: External respiratory data collected over entire treatment courses showed SDs from 1.6 to 8.1mm, the major part arising from baseline variations. The gated data had SDs from 1.5 to 7.7mm, with a mean reduction of 0.3mm (6...

  10. Low-dose-rate intraoperative brachytherapy combined with external beam irradiation in the conservative treatment of soft tissue sarcoma

    International Nuclear Information System (INIS)

    Delannes, M.; Thomas, L.; Martel, P.; Bonnevialle, P.; Stoeckle, E.; Chevreau, Ch.; Bui, B.N.; Daly-Schveitzer, N.; Pigneux, J.; Kantor, G.

    2000-01-01

    Purpose: Conservative treatment of soft tissue sarcomas most often implies combination of surgical resection and irradiation. The aim of this study was to evaluate low-dose-rate intraoperative brachytherapy, delivered as a boost, in the local control of primary tumors, with special concern about treatment complications. Methods and Materials: Between 1986 and 1995, 112 patients underwent intraoperative implant. This report focuses on the group of 58 patients with primary sarcomas treated by combination of conservative surgery, intraoperative brachytherapy, and external irradiation. Most of the tumors were located in the lower limbs (46/58--79%). Median size of the tumor was 10 cm, most of the lesions being T2-T3 (51/58--88%), Grade 2 or 3 (48/58--83%). The mean brachytherapy dose was 20 Gy and external beam irradiation dose 45 Gy. In 36/58 cases, iridium wires had to be placed on contact with neurovascular structures. Results: With a median follow-up of 54 months, the 5-year actuarial survival was 64.9%, with a 5-year actuarial local control of 89%. Of the 6 patients with local relapse, 3 were salvaged. Acute side effects, essentially wound healing problems, occurred in 20/58 patients, late side effects in 16/58 patients (7 neuropathies G2 to G4). No amputation was required. The only significant factor correlated with early side effects was the location of the tumor in the lower limb (p = 0.003), and with late side effects the vicinity of the tumor with neurovascular structures (p = 0.009). Conclusion: Brachytherapy allows early delivery of a boost dose in a reduced volume of tissue, precisely mapped by the intraoperative procedure. Combined with external beam irradiation, it is a safe and efficient treatment technique leading to high local control rates and limited functional impairment

  11. Beam steering for circular switched parasitic arrays using a combinational approach

    CSIR Research Space (South Africa)

    Mofolo, ROM

    2011-09-01

    Full Text Available of parasitic elements (P): ( )PsTotal Combinations = L . (4) If an On/Off switch is assumed and the antenna system in Fig. 1 is modelled, 16=24 combinations or parasitic loading configurations can be tested [19]. A. CPLM selection criteria..., Lenght?Width=300 mm?300 mm; and ? SubMiniature version A (SMA) connector 50 ?; used for feeding the active element. Although we assumed the use of an ideal On/Off RF switch in this work, the open-circuited parasitic elements were isolated from...

  12. Analysis on partial coherence propagation using the four-dimensional coherence function

    Science.gov (United States)

    Meng, Xiangyu; Xue, Chaofan; Yu, Huaina; Wang, Yong; Wu, Yanqing; Tai, Renzhong

    2017-08-01

    The mutual optical intensity (MOI) is a four-dimensional coherence function and contains the full coherence information of the beam. The propagation of mutual optical intensity through a soft x-ray beamline is analyzed with a new developed model named MOI. The MOI model is based on statistical optics. The wavefront is separated into many elements and every element is assumed to has full coherence and constant complex amplitude, which is reasonable if the dimension of element is much smaller than the coherent length and beam spot size. The propagation of MOI for every element can be analytically solved with Fraunhofer or Fresnel approximations. The total MOI propagation through free space can be obtained by summing the contribution of all elements. Local stationary phase approximation is implemented to simulate MOI propagating through ideal mirrors and gratings. The MOI model provides not only intensity profile, but also wavefront and coherence information of the beam. These advantages make MOI model a useful tool for beamline design and optimization. The nano-ARPES beamline at SSRF is analyzed using the MOI model. A zone plate is used to focus the beam. The intensity profile and local coherence degree at the zone plate are acquired. The horizontal coherence is much worse than the vertical one. By cutting the horizontal beam with the exit slit the horizontal coherence can be improved but at the flux loss. The quantitative analysis on the coherence improvement and flux loss at different exit slit size are obtained with the MOI model.

  13. Coherent Structures in Numerically Simulated Plasma Turbulence

    DEFF Research Database (Denmark)

    Kofoed-Hansen, O.; Pécseli, H.L.; Trulsen, J.

    1989-01-01

    Low level electrostatic ion acoustic turbulence generated by the ion-ion beam instability was investigated numerically. The fluctuations in potential were investigated by a conditional statistical analysis revealing propagating coherent structures having the form of negative potential wells which...

  14. On the combination of a low energy hydrogen atom beam with a cold multipole ion trap

    Energy Technology Data Exchange (ETDEWEB)

    Borodi, Gheorghe

    2008-12-09

    The first part of the activities of this thesis was to develop a sophisticated ion storage apparatus dedicated to study chemical processes with atomic hydrogen. The integration of a differentially pumped radical beam source into an existing temperature variable 22- pole trapping machine has required major modifications. Since astrophysical questions have been in the center of our interest, the introduction first gives a short overview of astrophysics and -chemistry. The basics of ion trapping in temperature variable rf traps is well-documented in the literature; therefore, the description of the basic instrument (Chapter 2) is kept rather short. Much effort has been put into the development of an intense and stable source for hydrogen atoms the kinetic energy of which can be changed. Chapter 3 describes this module in detail with emphasis on the integration of magnetic hexapoles for guiding the atoms and special treatments of the surfaces for reducing H-H recombination. Due to the unique sensitivity of the rf ion trapping technique, this instrument allows one to study a variety of reactions of astrochemical and fundamental interest. The results of this work are summarized in Chapter 4. Reactions of CO{sub 2}{sup +} with hydrogen atoms and molecules have been established as calibration standard for in situ determination of H and H{sub 2} densities over the full temperature range of the apparatus (10 K-300 K). For the first time, reactions of H- and D-atoms with the ionic hydrocarbons CH{sup +}, CH{sub 2}{sup +}, and CH{sub 4}{sup +} have been studied at temperatures of interstellar space. A very interesting, not yet fully understood collision system is the interaction of protonated methane with H. The outlook presents some ideas, how to improve the new instrument and a few reaction systems are mentioned which may be studied next. (orig.)

  15. Combined external-beam PIXE and {mu}-Raman characterisation of garnets used in Merovingian jewellery

    Energy Technology Data Exchange (ETDEWEB)

    Calligaro, T. E-mail: thomas.calligaro@culture.gouv.fr; Colinart, S.; Poirot, J.-P.; Sudres, C

    2002-04-01

    Red garnets were the dominant gemstones used for jewels in Europe during the Early Middle Ages. We have studied over 350 garnets set on 12 jewels unearthed in the royal necropolis of the Saint-Denis Basilica, close to Paris. This famous collection of 'cloisonne' style artefacts dates from the Merovingian period (late fifth century AD to early seventh century AD). The archaeological issue addressed is the identification of the geographical origin of these garnets, in view to establish the gem trading routes during the Dark Ages. External beam PIXE was used to determine the major constituents (Mg, Al, Si, Ca, Mn, Fe), specifying the garnet type (composition in various mineralogical end-members, e.g. almandine, pyrope, spessartite, ...), and the trace element content (Cr, Y). Three sorts of garnets were identified. Ten jewels are adorned with almandine garnets (Fe-rich). One jewel has intermediate almandine-pyrope garnets ('rhodolite'). The last and most recent jewel is inlaid with pyrope (Mg-rich) garnets. Trace element content and slight differences in major composition allowed to distinguish five different sources: two sources for pyrope garnets (with and without chromium), and two sources for almandine garnets (distinctive calcium, magnesium and yttrium contents). A preliminary comparison with literature data suggested that almandine garnets may have been mined from India while the 'rhodolite' garnets may have been imported from Sri Lanka. The sources of pyrope garnets could be the Bohemian deposits (Czech republic). In addition, {mu}-Raman spectrometry was used to identify most of the mineral inclusions (apatite, zircon, ilmenite, monazite, calcite, quartz) present in almandine garnets. Even if two specific types of inclusions were not identified, due to the lack of corresponding reference spectra in our database, the Raman spectra collected provided an interesting inclusion fingerprint.

  16. On the combination of a low energy hydrogen atom beam with a cold multipole ion trap

    International Nuclear Information System (INIS)

    Borodi, Gheorghe

    2008-01-01

    The first part of the activities of this thesis was to develop a sophisticated ion storage apparatus dedicated to study chemical processes with atomic hydrogen. The integration of a differentially pumped radical beam source into an existing temperature variable 22- pole trapping machine has required major modifications. Since astrophysical questions have been in the center of our interest, the introduction first gives a short overview of astrophysics and -chemistry. The basics of ion trapping in temperature variable rf traps is well-documented in the literature; therefore, the description of the basic instrument (Chapter 2) is kept rather short. Much effort has been put into the development of an intense and stable source for hydrogen atoms the kinetic energy of which can be changed. Chapter 3 describes this module in detail with emphasis on the integration of magnetic hexapoles for guiding the atoms and special treatments of the surfaces for reducing H-H recombination. Due to the unique sensitivity of the rf ion trapping technique, this instrument allows one to study a variety of reactions of astrochemical and fundamental interest. The results of this work are summarized in Chapter 4. Reactions of CO 2 + with hydrogen atoms and molecules have been established as calibration standard for in situ determination of H and H 2 densities over the full temperature range of the apparatus (10 K-300 K). For the first time, reactions of H- and D-atoms with the ionic hydrocarbons CH + , CH 2 + , and CH 4 + have been studied at temperatures of interstellar space. A very interesting, not yet fully understood collision system is the interaction of protonated methane with H. The outlook presents some ideas, how to improve the new instrument and a few reaction systems are mentioned which may be studied next. (orig.)

  17. Super-Monte Carla : a combined approach to x-ray beam planning

    International Nuclear Information System (INIS)

    Keall, P.; Hoban, P.

    1996-01-01

    A new accurate 3-D radiotherapy dose calculation algorithm, Super-Monte Carlo (SMC), has been developed which combines elements of both superposition/convolution and Monte Carlo methods. Currently used clinical dose calculation algorithms (except those based on the superposition method) can have errors of over 10%, especially where significant density inhomogeneities exist, such as in the head and neck, and lung regions. Errors of this magnitude can cause significan departures in the tumour control probability of the actual treatment. (author)

  18. Combining high power diode lasers using fiber bundles for beam delivery in optoacoustic endoscopy applications

    Science.gov (United States)

    Gawali, Sandeep Babu; Leggio, Luca; Sánchez, Miguel; Rodríguez, Sergio; Dadrasnia, Ehsan; Gallego, Daniel C.; Lamela, Horacio

    2016-05-01

    Optoacoustic (OA) effect refers to the generation of the acoustic waves due to absorption of light energy in a biological tissue. The incident laser pulse is absorbed by the tissue, resulting in the generation of ultrasound that is typically detected by a piezoelectric detector. Compared to other techniques, the advantage of OA imaging (OAI) technique consists in combining the high resolution of ultrasound technique with the high contrast of optical imaging. Generally, Nd:YAG and OPO systems are used for the generation of OA waves but their use in clinical environment is limited for many aspects. On the other hand, high-power diode lasers (HPDLs) emerge as potential alternative. However, the power of HPDLs is still relatively low compared to solid-state lasers. We show a side-by-side combination of several HPDLs in an optical fiber bundle to increase the amount of power for OA applications. Initially, we combine the output optical power of several HPDLs at 905 nm using two 7 to 1 round optical fiber bundles featuring a 675 μm and 1.2 mm bundle aperture. In a second step, we couple the output light of these fiber bundles to a 600 μm core diameter endoscopic fiber, reporting the corresponding coupling efficiencies. The fiber bundles with reasonable small diameter are likely to be used for providing sufficient light energy to potential OA endoscopy (OAE) applications.

  19. Coherent electron cooling

    Energy Technology Data Exchange (ETDEWEB)

    Litvinenko,V.

    2009-05-04

    Cooling intense high-energy hadron beams remains a major challenge in modern accelerator physics. Synchrotron radiation is still too feeble, while the efficiency of two other cooling methods, stochastic and electron, falls rapidly either at high bunch intensities (i.e. stochastic of protons) or at high energies (e-cooling). In this talk a specific scheme of a unique cooling technique, Coherent Electron Cooling, will be discussed. The idea of coherent electron cooling using electron beam instabilities was suggested by Derbenev in the early 1980s, but the scheme presented in this talk, with cooling times under an hour for 7 TeV protons in the LHC, would be possible only with present-day accelerator technology. This talk will discuss the principles and the main limitations of the Coherent Electron Cooling process. The talk will describe the main system components, based on a high-gain free electron laser driven by an energy recovery linac, and will present some numerical examples for ions and protons in RHIC and the LHC and for electron-hadron options for these colliders. BNL plans a demonstration of the idea in the near future.

  20. Combined binary collision and continuum mechanics model applied to focused ion beam milling of a silicon membrane

    International Nuclear Information System (INIS)

    Hobler, Gerhard

    2015-01-01

    Many experiments indicate the importance of stress and stress relaxation upon ion implantation. In this paper, a model is proposed that is capable of describing ballistic effects as well as stress relaxation by viscous flow. It combines atomistic binary collision simulation with continuum mechanics. The only parameters that enter the continuum model are the bulk modulus and the radiation-induced viscosity. The shear modulus can also be considered but shows only minor effects. A boundary-fitted grid is proposed that is usable both during the binary collision simulation and for the spatial discretization of the force balance equations. As an application, the milling of a slit into an amorphous silicon membrane with a 30 keV focused Ga beam is studied, which demonstrates the relevance of the new model compared to a more heuristic approach used in previous work

  1. Dry fabrication of microdevices by the combination of focused ion beam and cryogenic deep reactive ion etching

    International Nuclear Information System (INIS)

    Chekurov, N; Tittonen, I; Grigoras, K; Sainiemi, L; Franssila, S; Peltonen, A

    2010-01-01

    In this paper, we demonstrate silicon microdevice fabrication by a combination of focused ion beam (FIB) and cryogenic deep reactive ion etching (DRIE). Applying FIB treatment only to a thin surface layer enables very high writing speed compared with FIB milling. The use of DRIE then defines the micro- and nanodevices utilizing the FIB-modified silicon as a mask. We demonstrate the ability to create patterns on highly 3D structures, which is extremely challenging by other nanofabrication methods. The alignment of optically made and FIB-defined patterns is also demonstrated. We also show that complete microelectromechanical systems (MEMS) can be fabricated by this method by presenting a double-ended tuning fork resonator as an example. Extremely short process time is achieved as the full fabrication cycle from mask design to electrical measurements can be completed during one working day.

  2. Comparison of three-dimensional optical coherence tomography and combining a rotating Scheimpflug camera with a Placido topography system for forme fruste keratoconus diagnosis.

    Science.gov (United States)

    Fukuda, Shinichi; Beheregaray, Simone; Hoshi, Sujin; Yamanari, Masahiro; Lim, Yiheng; Hiraoka, Takahiro; Yasuno, Yoshiaki; Oshika, Tetsuro

    2013-12-01

    To evaluate the ability of parameters measured by three-dimensional (3D) corneal and anterior segment optical coherence tomography (CAS-OCT) and a rotating Scheimpflug camera combined with a Placido topography system (Scheimpflug camera with topography) to discriminate between normal eyes and forme fruste keratoconus. Forty-eight eyes of 48 patients with keratoconus, 25 eyes of 25 patients with forme fruste keratoconus and 128 eyes of 128 normal subjects were evaluated. Anterior and posterior keratometric parameters (steep K, flat K, average K), elevation, topographic parameters, regular and irregular astigmatism (spherical, asymmetry, regular and higher-order astigmatism) and five pachymetric parameters (minimum, minimum-median, inferior-superior, inferotemporal-superonasal, vertical thinnest location of the cornea) were measured using 3D CAS-OCT and a Scheimpflug camera with topography. The area under the receiver operating curve (AUROC) was calculated to assess the discrimination ability. Compatibility and repeatability of both devices were evaluated. Posterior surface elevation showed higher AUROC values in discrimination analysis of forme fruste keratoconus using both devices. Both instruments showed significant linear correlations (p<0.05, Pearson's correlation coefficient) and good repeatability (ICCs: 0.885-0.999) for normal and forme fruste keratoconus. Posterior elevation was the best discrimination parameter for forme fruste keratoconus. Both instruments presented good correlation and repeatability for this condition.

  3. The potential of high intensity focused ultrasound (HIFU) combine phase-sensitive optical coherence tomography (PhS-OCT) for diseases diagnosis, treatment and monitoring

    Science.gov (United States)

    Zhou, Kanheng; Wang, Yan; Feng, Kairui; Li, Chunhui; Huang, Zhihong

    2018-02-01

    HIFU is a truly noninvasive, acoustic therapeutic technique that utilizes high intensity acoustic field in the focus to kill the targeted tissue for disease treatment purpose. The mechanical properties of targeted tissue changes before and after treatment, and this change can be accurately detected by shear wave elastography. Hence, shear wave elastography is usually used for monitoring HIFU treatment asynchronously. To improve the low spatial resolution in ultrasound shear wave elastography, and to perform diseases diagnosis, treatment and monitoring in the same system, a new setup that combines HIFU and PhS-OCT system was proposed in this study. This proposed setup could do 1) HIFU treatment when the transducer works at high energy level, 2) ultrasound induced shear wave optical coherence elastography for HIFU treatment asynchronous monitoring when the transducer works at low energy level. Ex-vivo bovine liver tissue was treated at the same energy level for different time (0s, 1s, 5s, 9s) in this research. Elastography was performed on the lesion area of the sample after HIFU treatment, and the elastogram was reconstructed by the time of flight time method. The elastogram results clearly show the boundary of HIFU lesion area and surrounding normal tissue, even for 1s treatment time. And the average elasticity of the lesion grows linearly as the treatment time increases. Combined with OCT needle probe, the proposed method has a large potential not only to be used for superficial diseases treatment, but also to be used for high-precision-demanded diseases treatment, e.g. nervous disease treatment.

  4. Quantum coherence of electrons in random networks of c-axis oriented wedge-shaped GaN nanowalls grown by molecular beam epitaxy

    Science.gov (United States)

    Bhasker, H. P.; Thakur, Varun; Shivaprasad, S. M.; Dhar, S.

    2015-06-01

    The depth distribution of the transport properties as well as the temperature dependence of the low field magneto-conductance for c -axis oriented GaN nanowall network samples grown with different average wall-widths ({{t}\\text{av}} ) are investigated. Magneto-conductance recorded at low temperatures shows clear signature of weak localization effect in all samples studied here. The scattering mean free path {{l}e} and the phase coherence time {τφ} , are extracted from the magneto-conductance profile. Electron mobility estimated from {{l}e} is found to be comparable with those estimated previously from room temperature conductivity data for these samples, confirming independently the substantial mobility enhancement in these nanowalls as compared to bulk. Our study furthermore reveals that the high electron mobility region extends down to several hundreds of nanometer below the tip of the walls. Like mobility, phase coherence length ({{l}φ} ) is found to increase with the reduction of the average wall width. Interestingly, for samples with lower values of the average wall width, {{l}φ} is estimated to be as high as 60 μm, which is much larger than those reported for GaN/AlGaN heterostructure based two-dimensional electron gas (2DEG) systems.

  5. Nuclear-mass dependence of azimuthal beam-helicity and beam-charge asymmetries in deeply virtual Compton scattering

    Science.gov (United States)

    Airapetian, A.; Akopov, N.; Akopov, Z.; Amarian, M.; Aschenauer, E. C.; Augustyniak, W.; Avakian, R.; Avetissian, A.; Avetisyan, E.; Ball, B.; Belostotski, S.; Bianchi, N.; Blok, H. P.; Böttcher, H.; Borissov, A.; Bowles, J.; Bryzgalov, V.; Burns, J.; Capiluppi, M.; Capitani, G. P.; Cisbani, E.; Ciullo, G.; Contalbrigo, M.; Dalpiaz, P. F.; Deconinck, W.; Leo, R. De; Nardo, L. De; Sanctis, E. De; Diefenthaler, M.; Nezza, P. Di; Düren, M.; Ehrenfried, M.; Elbakian, G.; Ellinghaus, F.; Fabbri, R.; Fantoni, A.; Felawka, L.; Frullani, S.; Gabbert, D.; Gapienko, G.; Gapienko, V.; Garibaldi, F.; Gavrilov, G.; Gharibyan, V.; Giordano, F.; Gliske, S.; Guler, H.; Guzey, V.; Haan, S.; Hadjidakis, C.; Hartig, M.; Hasch, D.; Hill, G.; Hillenbrand, A.; Hoek, M.; Holler, Y.; Hristova, I.; Imazu, Y.; Ivanilov, A.; Jackson, H. E.; Jo, H. S.; Joosten, S.; Kaiser, R.; Karyan, G.; Keri, T.; Kinney, E.; Kisselev, A.; Korotkov, V.; Kozlov, V.; Kravchenko, P.; Lagamba, L.; Lamb, R.; Lapikás, L.; Lehmann, I.; Lenisa, P.; López Ruiz, A.; Lorenzon, W.; Lu, X.-G.; Lu, X.-R.; Ma, B.-Q.; Mahon, D.; Makins, N. C. R.; Manaenkov, S. I.; Manfré, L.; Mao, Y.; Marianski, B.; de La Ossa, A. Martinez; Marukyan, H.; Miller, C. A.; Miyachi, Y.; Movsisyan, A.; Muccifora, V.; Murray, M.; Mussgiller, A.; Nappi, E.; Naryshkin, Y.; Nass, A.; Negodaev, M.; Nowak, W.-D.; Pappalardo, L. L.; Perez-Benito, R.; Raithel, M.; Reimer, P. E.; Reolon, A. R.; Riedl, C.; Rith, K.; Rosner, G.; Rostomyan, A.; Rubin, J.; Ryckbosch, D.; Salomatin, Y.; Schäfer, A.; Schnell, G.; Schüler, K. P.; Shanidze, R.; Shibata, T.-A.; Shutov, V.; Stancari, M.; Statera, M.; Steffens, E.; Steijger, J. J. M.; Stewart, J.; Stinzing, F.; Taroian, S.; Terkulov, A.; Trzcinski, A.; Tytgat, M.; Vandenbroucke, A.; Haarlem, Y. Van; Hulse, C. Van; Varanda, M.; Veretennikov, D.; Vikhrov, V.; Vilardi, I.; Wang, S.; Yaschenko, S.; Ye, H.; Ye, Z.; Yu, W.; Zeiler, D.; Zihlmann, B.; Zupranski, P.; sHERMES Collaboration

    2010-03-01

    The nuclear-mass dependence of azimuthal cross-section asymmetries with respect to charge and longitudinal polarization of the lepton beam is studied for hard exclusive electroproduction of real photons. The observed beam-charge and beam-helicity asymmetries are attributed to the interference between the Bethe-Heitler and the deeply virtual Compton scattering processes. For various nuclei, the asymmetries are extracted for both coherent and incoherent-enriched regions, which involve different (combinations of) generalized parton distributions. For both regions, the asymmetries are compared to those for a free proton, and no nuclear-mass dependence is found.

  6. Nuclear-mass dependence of azimuthal beam-helicity and beam-charge asymmetries in deeply virtual Compton scattering

    Energy Technology Data Exchange (ETDEWEB)

    Airapetian, A. [Giessen Univ. (Germany). Physikalisches Inst.; Michigan Univ., Ann Arbor, MI (United States). Randall Lab. of Physics; Akopov, N. [Yerevan Physics Institute (Armenia); Akopov, Z. [DESY, Hamburg (DE)] (and others)

    2009-11-15

    The nuclear-mass dependence of azimuthal cross section asymmetries with respect to charge and longitudinal polarization of the lepton beam is studied for hard exclusive electroproduction of real photons. The observed beam-charge and beam-helicity asymmetries are attributed to the interference between the Bethe-Heitler and deeply virtual Compton scattering processes. For various nuclei, the asymmetries are extracted for both coherent and incoherent-enriched regions, which involve different (combinations of) generalized parton distributions. For both regions, the asymmetries are compared to those for a free proton, and no nuclear-mass dependence is found. (orig.)

  7. Combination of electron beam irradiation and thermal treatment to enhance the shelf-life of traditional Indian fermented food (Idli)

    Science.gov (United States)

    Mulmule, Manoj D.; Shimmy, Shankar M.; Bambole, Vaishali; Jamdar, Sahayog N.; Rawat, K. P.; Sarma, K. S. S.

    2017-02-01

    Idli, a steam-cooked breakfast food item consumed in India, is famous as a staple food for its spongy texture and unique fermented taste. Idli preparation is a time consuming process; although instant Idli pre-mixes as powder or batter are available in the market, they do not have the distinctive taste and aroma similar to the Idli prepared at home. Hence ready-to-eat (RTE) form of this food is in demand. Therefore, an attempt was made to prepare RTE Idli bearing similar taste as home-cooked Idli with an extended shelf-life of up to two months at an ambient temperature using Electron Beam Irradiation (EBI) at dosages 2.5 kGy, 5 kGy and 7.5 kGy and combination processing comprised of EBI dosage at 2.5 kGy and thermal treatment (80 °C for 20 min). The treated Idli's were microbiologically and sensorially evaluated at storage periods of zero day, 14 days, 30 days and 60 days. Idli's irradiated at 7.5 kGy and subjected to combination processing at 2.5 kGy and thermal treatment were shelf-stable for 60 days. 2.5 kGy and 5 kGy radiation dosages alone were not sufficient to preserve Idli samples for more than 14 days. Undesirable change in sensory properties of Idli was observed at an EBI dosage of 7.5 kGy. Sensory properties of combination processed Idli's were found to undergo minor change over the storage period. The present work suggests that lowest radiation dosage in combination with thermal treatment could be useful to achieve the extended shelf-life without considerably impairing the organoleptic quality of Ready-to-Eat Idli.

  8. Californium-252 neutron brachytherapy combined with external beam radiotherapy for esophageal cancer: long-term treatment results.

    Science.gov (United States)

    Liu, Huiming; Wang, Qifeng; Wan, Xin; Jia, Xitang; Liu, Bo; Wang, C-K Chris

    2014-01-01

    The aim of this study was to retrospectively observe and analyze the long-term treatment outcomes for a total of 952 esophageal cancer patients who were treated with (252)Cf neutron brachytherapy (NBT) in combination with external beam radiotherapy (EBRT). From November 2001 to March 2012, 952 patients with esophageal cancer underwent NBT in combination with EBRT. The patient numbers distributed over various cancer Stages I, IIA, IIB, III, and IVA were 9, 290, 51, 579, and 23, respectively. The total radiation dose to the reference point via NBT was 8-25 Gy-eq in three to five fractions with one fraction/week. The total dose via EBRT was 40-60 Gy delivered over a period of 5-6 weeks with normal fractionation. The overall median survival time was 20.3 months. The 1-, 3-, and 5-year survival rates were 67.1%, 36.3%, and 26.6%, respectively. These results compare favorably with the results obtained from conventional high-dose rate in combination with EBRT. Although a majority of the patients (860 or 90.3%) developed Grades 1 and 2 esophagitis during treatment, the symptoms were effectively relieved after the application of antacid and surface anesthesia. The clinical data show that NBT in combination with EBRT produced favorable local control and long-term survival rates for patients with esophageal cancer and that the side effects are tolerable. As such, we conclude that this dual-modality method is an effective and safe way for treating esophageal cancer. Published by Elsevier Inc.

  9. Combination of electron beam irradiation and thermal treatment to enhance the shelf-life of traditional Indian fermented food (Idli)

    International Nuclear Information System (INIS)

    Mulmule, Manoj D.; Shimmy, Shankar M.; Bambole, Vaishali; Jamdar, Sahayog N.; Rawat, K.P.; Sarma, K.S.S.

    2017-01-01

    Idli, a steam-cooked breakfast food item consumed in India, is famous as a staple food for its spongy texture and unique fermented taste. Idli preparation is a time consuming process; although instant Idli pre-mixes as powder or batter are available in the market, they do not have the distinctive taste and aroma similar to the Idli prepared at home. Hence ready-to-eat (RTE) form of this food is in demand. Therefore, an attempt was made to prepare RTE Idli bearing similar taste as home-cooked Idli with an extended shelf-life of up to two months at an ambient temperature using Electron Beam Irradiation (EBI) at dosages 2.5 kGy, 5 kGy and 7.5 kGy and combination processing comprised of EBI dosage at 2.5 kGy and thermal treatment (80 °C for 20 min). The treated Idli's were microbiologically and sensorially evaluated at storage periods of zero day, 14 days, 30 days and 60 days. Idli's irradiated at 7.5 kGy and subjected to combination processing at 2.5 kGy and thermal treatment were shelf-stable for 60 days. 2.5 kGy and 5 kGy radiation dosages alone were not sufficient to preserve Idli samples for more than 14 days. Undesirable change in sensory properties of Idli was observed at an EBI dosage of 7.5 kGy. Sensory properties of combination processed Idli's were found to undergo minor change over the storage period. The present work suggests that lowest radiation dosage in combination with thermal treatment could be useful to achieve the extended shelf-life without considerably impairing the organoleptic quality of Ready-to-Eat Idli. - Highlights: • Idli (traditional Indian fermented food) was prepared in ready-to-eat (RTE) form. • Ready-to-eat Idli was then subjected to combination processing comprised of lowest irradiation dosage of 2.5 kGy with mild heat treatment to extend its shelf life. • Increase in hardness and decrease in brightness of combination processed Idli was observed. • Combination processed Idli was microbiologically safe and

  10. Effects of electron beam irradiation combined with hot water immersion treatment for shelf life extension of bananas

    International Nuclear Information System (INIS)

    Russly Abdul Rahman

    1996-01-01

    A study of the effects of minimal processing treatments, both individually or in combinations, was carried out in order to extend the shelf life and to improve the quality of bananas. Pre climacteric bananas at light full three-quarter grade, were either treated with hot water immersion for 1-30 min at 45-55 degree C, or irradiated with electron beams (2.0 MeV, Van de Graaff accelerator), to a dose of 0.1-1.5 kGy. All fruit was stored at 21 ± 1 degree C and relative humidity of 85-95 %. There was no significant delay in ripening of fruit treated with hot water immersion at the above temperatures. Some damage to fruit particularly peel scalding at ends occurred at the higher temperatures (>50 degree C). The 50 degree C, 5 minutes immersion was selected for further study. Irradiation to 0.1-0.3 kGy delayed the ripening (up to 3 days) without affecting fruit quality. Doses greater than 0.4 kGy resulted in extensive discoloration and fruit splitting. No significant differences could be detected organoleptically between bananas irradiated at 0.15 kGy and the control. Results of the physico-chemical attributes of the bananas were reported for fruits at colour stage 5 and after 10 and 15 days of storage. The combination treatment of hot water immersion and irradiation at the above settings further extended the shelf life of the banana fruits

  11. Osteogenesis effect of guided bone regeneration combined with alveolar cleft grafting: assessment by cone beam computed tomography.

    Science.gov (United States)

    Xiao, W-L; Zhang, D-Z; Chen, X-J; Yuan, C; Xue, L-F

    2016-06-01

    Cone beam computed tomography (CBCT) allows for a significantly lower radiation dose than conventional computed tomography (CT) scans and provides accurate images of the alveolar cleft area. The osteogenic effect of guided bone regeneration (GBR) vs. conventional alveolar bone grafting alone for alveolar cleft defects was evaluated in this study. Sixty alveolar cleft patients were divided randomly into two groups. One group underwent GBR using acellular dermal matrix film combined with alveolar bone grafting using iliac crest bone grafts (GBR group), while the other group underwent alveolar bone grafting only (non-GBR group). CBCT images were obtained at 1 week and at 3 months following the procedure. Using Simplant 11.04 software, the bone resorption rate was calculated and compared between the two groups. The bone resorption rate from 1 week to 3 months following bone grafting without the GBR technique was 36.50±5.04%, whereas the bone resorption rate using the GBR technique was 31.69±5.50% (P=0.017). The application of autogenous iliac bone combined with the GBR technique for alveolar bone grafting of alveolar cleft patients can reduce bone resorption and result in better osteogenesis. Copyright © 2016. Published by Elsevier Ltd.

  12. Scintillation reduction for laser beams propagating through turbulent atmosphere

    International Nuclear Information System (INIS)

    Berman, G P; Gorshkov, V N; Torous, S V

    2011-01-01

    We numerically examine the spatial evolution of the structure of coherent and partially coherent laser beams, including the optical vortices, propagating in turbulent atmospheres. The influence of beam fragmentation and wandering relative to the axis of propagation (z-axis) on the value of the scintillation index (SI) of the signal at the detector is analysed. These studies were performed for different dimensions of the detector, distances of propagation, and strengths of the atmospheric turbulence. Methods for significantly reducing the SI are described. These methods utilize averaging of the signal at the detector over a set of partially coherent beams (PCBs). It is demonstrated that the most effective approach is using a set of PCBs with definite initial directions of propagation relative to the z-axis. This approach results in a significant compensation of the beam wandering which in many cases is the main contributor to the SI. A novel method is to generate the PCBs by combining two laser beams-Gaussian and vortex beams, with different frequencies (the difference between these two frequencies being significantly smaller than the frequencies themselves). In this case, the effective suppression of the SI does not require high-frequency modulators. This result is important for achieving gigabit data rates in long-distance laser communication through turbulent atmospheres.

  13. The prophylactic effect of neck irradiation combined with intra-oral electron beam irradiation for early tongue cancer

    International Nuclear Information System (INIS)

    Kawamori, Jiro; Kamata, Rikisaburo; Sanuki, Eiichi

    1993-01-01

    Between 1967 and 1988, 102 patients with Stage T1-2N0 squamous cell carcinoma of the tongue were treated with uneven fractional irradiation therapy (intra-oral electron beam irradiation with and without prophylactic ipsilateral upper neck irradiation at the Dept. of Radiology, Nihon University School of Medicine. Of 102 primary lesions, 89 cases were controlled with this therapy. In this study, these 89 cases were investigated in order to analyze the prophylactic effect of upper neck irradiation. Of the 89 patients, 42 received only intra-oral electron beam irradiation, while the remaining 47 received a combination of intra-oral electron beam irradiation and prophylactic irradiation to the ipsilateral upper neck. Twenty three of the 89 (25.8%) developed metastasis to the neck after the radiotherapy. A breakdown of these 23 cases reveals that 3/21 (14.3%) received 40-50 Gy to the neck, 9/26 (34.6%) received 20-40 Gy to the neck, and 11/42 (26.2%) received no irradiation to the neck (p<0.05 between first and second groups, and between first and third groups). The neck metastasis was classified into one of three categories based on the region in which it first appeared (ipsilateral upper neck, ipsilateral lower neck or contralateral neck). The first metastasis was seen in the ipsilateral upper neck, in the ipsilateral lower neck and in the contralateral neck in 17, 4 and 2 patients, respectively. In 1/19 who had received 40-50 Gy, in 5/21 who had received 20-40 Gy and in 11/42 who had not received neck irradiation the first metastasis appeared in the ipsilateral upper neck. The five year survival rate was 94%, 75% and 85% in the patients receiving 40-50 Gy, 20-40 Gy and no neck irradiation, respectively. These results suggest that prophylactic irradiation of 40-50 Gy to the ipsilateral upper neck might decrease the incidence of neck metastasis and slightly prolong survival time. (author)

  14. Design of a Multi-Pinhole Collimator for I-123 DaTscan Imaging on Dual-Headed SPECT Systems in Combination with a Fan-Beam Collimator.

    Science.gov (United States)

    King, Michael A; Mukherjee, Joyeeta M; Könik, Arda; Zubal, I George; Dey, Joyoni; Licho, Robert

    2016-02-01

    For the 2011 FDA approved Parkinson's Disease (PD) SPECT imaging agent I-123 labeled DaTscan, the volume of interest (VOI) is the interior portion of the brain. However imaging of the occipital lobe is also required with PD for calculation of the striatal binding ratio (SBR), a parameter of significance in early diagnosis, differentiation of PD from other disorders with similar clinical presentations, and monitoring progression. Thus we propose the usage of a combination of a multi-pinhole (MPH) collimator on one head of the SPECT system and a fan-beam on the other. The MPH would be designed to provide high resolution and sensitivity for imaging of the interior portion of the brain. The fan-beam collimator would provide lower resolution but complete sampling of the brain addressing data sufficiency and allowing a volume-of-interest to be defined over the occipital lobe for calculation of SBR's. Herein we focus on the design of the MPH component of the combined system. Combined reconstruction will be addressed in a subsequent publication. An analysis of 46 clinical DaTscan studies was performed to provide information to define the VOI, and design of a MPH collimator to image this VOI. The system spatial resolution for the MPH was set to 4.7 mm, which is comparable to that of clinical PET systems, and significantly smaller than that of fan-beam collimators employed in SPECT. With this set, we compared system sensitivities for three aperture array designs, and selected the 3 × 3 array due to it being the highest of the three. The combined sensitivity of the apertures for it was similar to that of an ultra-high resolution fan-beam (LEUHRF) collimator, but smaller than that of a high-resolution fan-beam collimator (LEHRF). On the basis of these results we propose the further exploration of this design through simulations, and the development of combined MPH and fan-beam reconstruction.

  15. Young adults' medicine use for headache: the combined effect of socioeconomic position and perceived stress, and the contribution of sense of coherence.

    Science.gov (United States)

    Koushede, Vibeke; Hansen, Ebba Holme; Andersen, Anette; Holstein, Bjørn E

    2012-01-01

    Over-the-counter analgesic (OTCA) use is increasingly common and may have potential harmful side effects. The primary reason for using analgesics is headache symptoms. Whether OTCA use for headache is sensitive to psychosocial and social circumstances is an understudied topic. The purpose of this study was to examine the combined effect of socioeconomic position (SEP) and perceived stress on OTCA use for headache. An additional objective was to determine whether sense of coherence (SOC) modifies the association. Data derived from the cross-sectional "Danish Lifestyle and Medicine Use Study," 2009. The study population consisted of men and women ages 25-44 years (n = 955). The dependent variable was OTCA use for headache within the past 14 days. The independent variables were SEP, perceived stress, and SOC. Gender, headache prevalence, and response method were included as covariates. Associations were examined by means of logistic regression analyses, and reported as odds ratios (ORs) with 95% confidence intervals. The OR for OTCA use was 1.42 (0.94-2.14) (statistically nonsignificant) among participants with low SEP but no perceived stress (reference high SEP, no perceived stress), 2.09 (1.53-2.85) for participants with perceived stress and high SEP, and 2.65 (1.66-4.25) among participants with perceived stress and low SEP. In analysis, stratified by SOC associations were stronger among participants with low SOC than among those with high SOC. Individuals exposed to both low SEP and high perceived stress have high odds for using OTCA for headache, apparently higher than participants only exposed to 1 of these factors. SOC may act as a buffer against the harmful effects of perceived stress and low SEP on OTCA use. Health care professionals and policymakers need to be aware of the sensitivity of OTCA use to psychosocial and social circumstances. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Measurement of the Intertablet Coating Uniformity of a Pharmaceutical Pan Coating Process With Combined Terahertz and Optical Coherence Tomography In-Line Sensing.

    Science.gov (United States)

    Lin, Hungyen; Dong, Yue; Markl, Daniel; Williams, Bryan M; Zheng, Yalin; Shen, Yaochun; Zeitler, J Axel

    2017-04-01

    We present in-line coating thickness measurements acquired simultaneously using 2 independent sensing modalities: terahertz pulsed imaging (TPI) and optical coherence tomography (OCT). Both techniques are sufficiently fast to resolve the coating thickness of individual pharmaceutical tablets in situ during the film coating operation, and both techniques are direct structural imaging techniques that do not require multivariate calibration. The TPI sensor is suitable to measure coatings greater than 50 μm and can penetrate through thick coatings even in the presence of pigments over a wide range of excipients. Due to the long wavelength, terahertz radiation is not affected by scattering from dust within the coater. In contrast, OCT can resolve coating layers as thin as 20 μm and is capable of measuring the intratablet coating uniformity and the intertablet coating thickness distribution within the coating pan. However, the OCT technique is less robust when it comes to the compatibility with excipients, dust, and potentially the maximum coating thickness that can be resolved. Using a custom-built laboratory scale coating unit, the coating thickness measurements were acquired independently by the TPI and OCT sensors throughout a film coating operation. Results of the in-line TPI and OCT measurements were compared against one another and validated with off-line TPI and weight gain measurements. Compared with other process analytical technology sensors, such as near-infrared and Raman spectroscopy, the TPI and OCT sensors can resolve the intertablet thickness distribution based on sampling a significant fraction of the tablet populations in the process. By combining 2 complementary sensing modalities, it was possible to seamlessly monitor the coating process over the range of film thickness from 20 μm to greater than 250 μm. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Combined multimodal photoacoustic tomography, optical coherence tomography (OCT) and OCT based angiography system for in vivo imaging of multiple skin disorders in human(Conference Presentation)

    Science.gov (United States)

    Liu, Mengyang; Chen, Zhe; Sinz, Christoph; Rank, Elisabet; Zabihian, Behrooz; Zhang, Edward Z.; Beard, Paul C.; Kittler, Harald; Drexler, Wolfgang

    2017-02-01

    All optical photoacoustic tomography (PAT) using a planar Fabry-Perot interferometer polymer film sensor has been demonstrated for in vivo human palm imaging with an imaging penetration depth of 5 mm. The relatively larger vessels in the superficial plexus and the vessels in the dermal plexus are visible in PAT. However, due to both resolution and sensitivity limits, all optical PAT cannot reveal the smaller vessels such as capillary loops and venules. Melanin absorption also sometimes causes difficulties in PAT to resolve vessels. Optical coherence tomography (OCT) based angiography, on the other hand, has been proven suitable for microvasculature visualization in the first couple millimeters in human. In our work, we combine an all optical PAT system with an OCT system featuring a phase stable akinetic swept source. This multimodal PAT/OCT/OCT-angiography system provides us co-registered human skin vasculature information as well as the structural information of cutaneous. The scanning units of the sub-systems are assembled into one probe, which is then mounted onto a portable rack. The probe and rack design gives six degrees of freedom, allowing the multimodal optical imaging probe to access nearly all regions of human body. Utilizing this probe, we perform imaging on patients with various skin disorders as well as on healthy controls. Fused PAT/OCT-angiography volume shows the complete blood vessel network in human skin, which is further embedded in the morphology provided by OCT. A comparison between the results from the disordered regions and the normal regions demonstrates the clinical translational value of this multimodal optical imaging system in dermatology.

  18. Breast conserving surgery in combination with intraoperative radiotherapy after previous external beam therapy: an option to avoid mastectomy.

    Science.gov (United States)

    Thangarajah, F; Heilmann, J; Malter, W; Kunze, S; Marnitz, S; Mallmann, P; Wenz, F; Sperk, E

    2018-04-01

    Mastectomy is the standard procedure in patients with in-breast tumor recurrence (IBTR) or breast cancer after irradiation of the chest due to Hodgkin's disease. In certain cases a second breast conserving surgery (BCS) in combination with intraoperative radiotherapy (IORT) is possible. To date, data concerning BCS in combination with IORT in pre-irradiated patients are limited. This is the first pooled analysis of this special indication with a mature follow-up of 5 years. Patients with IBTR after external beam radiotherapy (EBRT; treated in two centers) for breast cancer were included. Patients with previous EBRT including the breast tissue due to other diseases were also included. IORT was performed with the Intrabeam™-device using low kV X-rays. Clinical data including outcome for all patients and toxicity for a representative cohort (LENT-SOMA scales) were obtained. Statistical analyses were done including Kaplan-Meier estimates for local recurrence, distant metastasis and overall survival. A total of 41 patients were identified (39 patients with IBTR, 2 with Hodgkin`s disease in previous medical history). Median follow-up was 58 months (range 4-170). No grade 3/4 acute toxicity occurred within 9 weeks. Local recurrence-free survival rate was 89.9% and overall survival was 82.7% at 5 years. Seven patients developed metastasis within the whole follow-up. BCS in combination with IORT in IBTR in pre-irradiated patients is a feasible method to avoid mastectomy with a low risk of side effects and an excellent local control and good overall survival.

  19. Californium-252 Brachytherapy Combined With External-Beam Radiotherapy for Cervical Cancer: Long-Term Treatment Results

    International Nuclear Information System (INIS)

    Lei Xin; Qian Chengyuan; Qing Yi; Zhao Kewei; Yang Zhengzhou; Dai Nan; Zhong Zhaoyang; Tang Cheng; Li Zheng; Gu Xianqing; Zhou Qian; Feng Yan; Xiong Yanli; Shan Jinlu; Wang Dong

    2011-01-01

    Purpose: To observe, by retrospective analysis, the curative effects and complications due to californium-252 ( 252 Cf) neutron intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT) in the treatment of cervical cancer. Methods and Materials: From February 1999 to December 2007, 696 patients with cervical cancer (Stages IB to IIIB) were treated with 252 Cf-ICBT in combination of EBRT. Of all, 31 patients were at Stage IB, 104 at IIA, 363 at IIB, 64 at IIIA, and 134 at IIIB. Californium-252 ICBT was delivered at 7–12 Gy per insertion per week, with a total dose of 29–45 Gy to reference point A in three to five insertions. The whole pelvic cavity was treated with 8-MV X-ray external irradiation at 2 Gy per fraction, four times per week. After 16–38 Gy of external irradiation, the center of the whole pelvic field was blocked with a 4-cm-wide lead shield, with a total external irradiation dose of 44–56 Gy. The total treatment course was 5 to 6 weeks. Results: Overall survival rate at 3 and 5 years for all patients was 76.0% and 64.9%, respectively. Disease-free 3- and 5-year survival rates of patients were 71.2% and 58.4%, respectively. Late complications included vaginal contracture and adhesion, radiation proctitis, radiation cystitis, and inflammatory bowel, which accounted for 5.8%, 7.1%, 6.2%, and 4.9%, respectively. Univariate analysis results showed significant correlation of stage, age, histopathologic grade, and lymph node status with overall survival. Cox multiple regression analysis showed that the independent variables were stage, histopathologic grade, tumor size, and lymphatic metastasis in all patients. Conclusion: Results of this series suggest that the combined use of 252 Cf-ICBT with EBRT is an effective method for treatment of cervical cancer.

  20. Californium-252 Brachytherapy Combined With External-Beam Radiotherapy for Cervical Cancer: Long-Term Treatment Results

    Energy Technology Data Exchange (ETDEWEB)

    Lei Xin; Qian Chengyuan; Qing Yi; Zhao Kewei; Yang Zhengzhou; Dai Nan; Zhong Zhaoyang; Tang Cheng; Li Zheng; Gu Xianqing; Zhou Qian; Feng Yan; Xiong Yanli; Shan Jinlu [Cancer Center, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing (China); Wang Dong, E-mail: dongwang64@hotmail.com [Cancer Center, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing (China)

    2011-12-01

    Purpose: To observe, by retrospective analysis, the curative effects and complications due to californium-252 ({sup 252}Cf) neutron intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT) in the treatment of cervical cancer. Methods and Materials: From February 1999 to December 2007, 696 patients with cervical cancer (Stages IB to IIIB) were treated with {sup 252}Cf-ICBT in combination of EBRT. Of all, 31 patients were at Stage IB, 104 at IIA, 363 at IIB, 64 at IIIA, and 134 at IIIB. Californium-252 ICBT was delivered at 7-12 Gy per insertion per week, with a total dose of 29-45 Gy to reference point A in three to five insertions. The whole pelvic cavity was treated with 8-MV X-ray external irradiation at 2 Gy per fraction, four times per week. After 16-38 Gy of external irradiation, the center of the whole pelvic field was blocked with a 4-cm-wide lead shield, with a total external irradiation dose of 44-56 Gy. The total treatment course was 5 to 6 weeks. Results: Overall survival rate at 3 and 5 years for all patients was 76.0% and 64.9%, respectively. Disease-free 3- and 5-year survival rates of patients were 71.2% and 58.4%, respectively. Late complications included vaginal contracture and adhesion, radiation proctitis, radiation cystitis, and inflammatory bowel, which accounted for 5.8%, 7.1%, 6.2%, and 4.9%, respectively. Univariate analysis results showed significant correlation of stage, age, histopathologic grade, and lymph node status with overall survival. Cox multiple regression analysis showed that the independent variables were stage, histopathologic grade, tumor size, and lymphatic metastasis in all patients. Conclusion: Results of this series suggest that the combined use of {sup 252}Cf-ICBT with EBRT is an effective method for treatment of cervical cancer.

  1. Californium-252 brachytherapy combined with external-beam radiotherapy for cervical cancer: long-term treatment results.

    Science.gov (United States)

    Lei, Xin; Qian, Cheng-Yuan; Qing, Yi; Zhao, Ke-Wei; Yang, Zheng-Zhou; Dai, Nan; Zhong, Zhao-Yang; Tang, Cheng; Li, Zheng; Gu, Xian-Qing; Zhou, Qian; Feng, Yan; Xiong, Yan-Li; Shan, Jin-Lu; Wang, Dong

    2011-12-01

    To observe, by retrospective analysis, the curative effects and complications due to californium-252 (252Cf) neutron intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT) in the treatment of cervical cancer. From February 1999 to December 2007, 696 patients with cervical cancer (Stages IB to IIIB) were treated with 252Cf-ICBT in combination of EBRT. Of all, 31 patients were at Stage IB, 104 at IIA, 363 at IIB, 64 at IIIA, and 134 at IIIB. Californium-252 ICBT was delivered at 7-12 Gy per insertion per week, with a total dose of 29-45 Gy to reference point A in three to five insertions. The whole pelvic cavity was treated with 8-MV X-ray external irradiation at 2 Gy per fraction, four times per week. After 16-38 Gy of external irradiation, the center of the whole pelvic field was blocked with a 4-cm-wide lead shield, with a total external irradiation dose of 44-56 Gy. The total treatment course was 5 to 6 weeks. Overall survival rate at 3 and 5 years for all patients was 76.0% and 64.9%, respectively. Disease-free 3- and 5-year survival rates of patients were 71.2% and 58.4%, respectively. Late complications included vaginal contracture and adhesion, radiation proctitis, radiation cystitis, and inflammatory bowel, which accounted for 5.8%, 7.1%, 6.2%, and 4.9%, respectively. Univariate analysis results showed significant correlation of stage, age, histopathologic grade, and lymph node status with overall survival. Cox multiple regression analysis showed that the independent variables were stage, histopathologic grade, tumor size, and lymphatic metastasis in all patients. Results of this series suggest that the combined use of 252Cf-ICBT with EBRT is an effective method for treatment of cervical cancer. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non- culprit lesions to better predict adverse event outcomes in diabetes mellitus patients: COMBINE (OCT-FFR) prospective study. Rationale and design.

    Science.gov (United States)

    Kennedy, Mark W; Fabris, Enrico; Ijsselmuiden, Alexander J; Nef, Holger; Reith, Sebastian; Escaned, Javier; Alfonso, Fernando; van Royen, Niels; Wojakowski, Wojtek; Witkowski, Adam; Indolfi, Ciro; Ottervanger, Jan Paul; Suryapranata, Harry; Kedhi, Elvin

    2016-10-10

    Fractional flow reserve (FFR) is a widely used tool for the identification of ischaemia-generating stenoses and to guide decisions on coronary revascularisation. However, the safety of FFR-based decisions in high-risk subsets, such as patients with Diabetes Mellitus (DM) or vulnerable stenoses presenting thin-cap fibro-atheroma (TCFA), is unknown. This study will examine the impact of optical coherence tomography (OCT) plaque morphological assessment and the identification of TCFA, in combination with FFR to better predict clinical outcomes in DM patients. COMBINE (OCT-FFR) is a prospective, multi-centre study investigating the natural history of DM patients with ≥1 angiographically intermediate target lesion in three subgroups of patients; patients with FFR negative lesions without TCFA (group A) and patients with FFR negative lesions with TCFA (group B) as detected by OCT and to compare these two groups with each other, as well as to a third group with FFR-positive, PCI-treated intermediate lesions (group C). The study hypothesis is that DM patients with TCFA (group B) have a worse outcome than those without TCFA (group A) and also when compared to those patients with lesions FFR ≤0.80 who underwent complete revascularisation. The primary endpoint is the incidence of target lesion major adverse cardiac events (MACE); a composite of cardiac death, myocardial infarction or rehospitalisation for unstable/progressive angina in group B vs. group A. COMBINE (OCT-FFR) is the first prospective study to examine whether the addition of OCT plaque morphological evaluation to FFR haemodynamic assessment of intermediate lesions in DM patients will better predict MACE and possibly lead to new revascularisation strategies. Trial Registration Netherlands Trial Register: NTR5376.

  3. Application of Frequency Diversity to Suppress Grating Lobes in Coherent MIMO Radar with Separated Subapertures

    Directory of Open Access Journals (Sweden)

    Xingzhao Liu

    2009-01-01

    Full Text Available A method based on frequency diversity to suppress grating lobes in coherent MIMO radar with separated subapertures is proposed. By transmitting orthogonal waveforms from M separated subapertures or subarrays, M receiving beams can be formed at the receiving end with the same mainlobe direction. However, grating lobes would change to different positions if the frequencies of the radiated waveforms are incremented by a frequency offset Δf from subarray to subarray. Coherently combining the M beams can suppress or average grating lobes to a low level. We show that the resultant transmit-receive beampattern is composed of the range-dependent transmitting beam and the combined receiving beam. It is demonstrated that the range-dependent transmitting beam can also be frequency offset-dependent. Precisely directing the transmitting beam to a target with a known range and a known angle can be achieved by properly selecting a set of Δf. The suppression effects of different schemes of selecting Δf are evaluated and studied by simulation.

  4. Comparison of treatment using teletherapy (external beam radiation) alone versus teletherapy combined with brachytherapy for advanced squamous cell carcinoma of the esophagus

    International Nuclear Information System (INIS)

    Samea, Renato; Lourenco, Laercio Gomes

    2011-01-01

    Background - Squamous cell carcinoma of the esophagus is still a difficult tumor to treat with very poor prognosis. Aim - To compare the response to teletherapy treatment (external beam radiotherapy) alone versus teletherapy combined with brachytherapy for patients with advanced squamous cell carcinoma of the esophagus. Methods - Were studied 49 patients with advanced squamous cell carcinoma of the esophagus on clinical stage III (TNM-1999). They were separated into two groups. The first, underwent radiation therapy alone with linear accelerator of particles, average dose of 6000 cGy and the second to external beam radiation therapy at a dose of 5040 cGy combined with brachytherapy with Iridium 192 at a dose of 1500 cGy. Brachytherapy started one to two weeks after the end of teletherapy, and it was divided into three weekly applications of 500 cGy. Age, gender, race, habits (smoking and drinking), body mass index (BMI), complications with treatment benefits (pain relief and food satisfaction) and survival were analyzed. Results - The quality of life (food satisfaction, and pain palliation of dysphagia) were better in the group treated with external beam radiation therapy combined with brachytherapy. Survival was higher in the brachytherapy combined with external beam radiation therapy alone. Conclusion - Although the cure rate of squamous cell cancer of the esophagus is almost nil when treated with irradiation alone, this therapy is a form of palliative treatment for most patients in whom surgical contraindication exists. (author)

  5. Beam instability induced by rf deflectors in the combiner ring of the CLIC test facility and mitigation by damped deflecting structures

    Directory of Open Access Journals (Sweden)

    David Alesini

    2011-02-01

    Full Text Available In the CTF3 (CLIC test facility 3 run of November 2007, a vertical beam instability has been found in the combiner ring during operation. After a careful analysis, the source of the instability has been identified in the vertical deflecting modes trapped in the rf deflectors and excited by the beam passage. A dedicated tracking code that includes the induced transverse wakefield and the multibunch multipassage effects has been written and the results of the beam dynamics analysis are presented in the paper. The mechanism of the instability was similar to the beam breakup in a linear accelerator or in an energy recovery linac. The results of the code allowed identifying the main key parameters driving such instability and allowed finding the main knobs to mitigate it. To completely suppress such beam instability, two new rf deflectors have been designed, constructed, and installed in the ring. In the new structures the frequency separation between the vertical and horizontal deflecting modes has been increased, changing the position of the rods inside the cells, and special antennas have been inserted to absorb the power released by the beam to the modes. The deflectors have been made in aluminum to reduce the costs and delivery time and have been successfully tested and installed in the ring. The design, the realization procedures, and the rf test results are illustrated.

  6. Coherence and Sense of Coherence

    DEFF Research Database (Denmark)

    Dau, Susanne

    2014-01-01

    of coherence is both related to conditional matters as learning environments, structure, clarity and linkage but also preconditioned matters and prerequisites among participants related to experiences and convenience. It is stressed that this calls for continuous assessment and reflections upon these terms...

  7. Transverse mode coupling instability of colliding beams

    Directory of Open Access Journals (Sweden)

    S. White

    2014-04-01

    Full Text Available In high brightness circular colliders, coherent and incoherent beam dynamics are dominated by beam-beam interactions. It is generally assumed that the incoherent tune spread introduced by the beam-beam interactions is sufficiently large to cure any instabilities originating from impedance. However, as the two counterrotating beams interact they can give rise to coherent dipole modes and therefore modify the coherent beam dynamics and stability conditions. In this case, coherent beam-beam effects and impedance cannot be treated independently and their interplay should be taken into account in any realistic attempt to study the beam stability of colliding beams. Due to the complexity of these physics processes, numerical simulations become an important tool for the analysis of this system. Two approaches are proposed in this paper: a fully self-consistent multiparticle tracking including particle-in-cell Poisson solver for the beam-beam interactions and a linearized model taking into account finite bunch length effects. To ensure the validity of the results a detailed benchmarking of these models was performed. It will be shown that under certain conditions coherent beam-beam dipole modes can couple with higher order headtail modes and lead to strong instabilities with characteristics similar to the classical transverse mode coupling instability originating from impedance alone. Possible cures for this instability are explored both for single bunch and multibunch interactions. Simulation results and experimental evidences of the existence of this instability at the LHC will be presented for the specific case of offset collisions.

  8. Emittance preservation during bunch compression with a magnetized beam

    Energy Technology Data Exchange (ETDEWEB)

    Stratakis, Diktys [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-09-02

    The deleterious effects of coherent synchrotron radiation (CSR) on the phase-space and energy spread of high-energy beams in accelerator light sources can significantly constrain the machine design and performance. In this paper, we present a simple method to preserve the beam emittance by means of using magnetized beams that exhibit a large aspect ratio on their transverse dimensions. The concept is based on combining a finite solenoid field where the beam is generated together with a special optics adapter. Numerical simulations of this new type of beam source show that the induced phase-space density growth can be notably suppressed to less than 1% for any bunch charge. This work elucidates the key parameters that are needed for emittance preservation, such as the required field and aspect ratio for a given bunch charge.

  9. Validation of the Local Hadronic Calibration Scheme of ATLAS with Combined Beam Test Data in the End-Cap and Forward Regions of ATLAS

    CERN Document Server

    Kiryunin, A; The ATLAS collaboration

    2011-01-01

    The three Atlas calorimeter systems in the region of the forward crack at |eta| = 3.2 in the nominal Atlas setup have been exposed to combined beam tests with single electrons and pions. Detailed shower shape studies of electrons and pions with comparisons to various Geant4 based simulations utilizing different physics lists are presented. The Local Hadron Calibration developed for the energy reconstruction and the calibration of jets and missing transverse energy in ATLAS, has been validated using data obtained during these beam tests. The analysis has been carried out by using special sets of calibration weights and corrections obtained with the Geant4 simulation of a detailed beam test set-up. The validation itself has been performed by careful studying specific calorimeter performance parameters such as e.g. energy response, energy resolution, shower shapes, cluster energy density as well as different physics lists of the Geant4 simulation.

  10. Improvement of an infrared/millimeter wave mirror array beam combiner by the wavefront division imaging technique.

    Science.gov (United States)

    Tian, Yi; Sun, Gang; Yan, Hui; Zhang, Li; Li, Zhuo

    2014-10-10

    In order to reduce the complexity of splicing the mirrors of an infrared (IR)/millimeter wave (MMW) beam combiner into a plane, the wavefront division imaging technique (WDIT) was proposed. However, WDIT would lead to the difference of air gap thicknesses among different mirrors, which will further cause the nonuniformity of the MMW field. Simultaneously, there were slots between every two mirrors after the mirror array was spliced and adjusted, which would also affect MMW and IR diffraction. Thus, the aperture field integration method (AFIM) was proposed to compute the MMW near field distribution and the IR far field distribution. The method was validated by comparing the results obtained from the multilevel fast multipole method and experiment. The experimental results showed that the diffraction phenomenon caused by a tilt slot or a hole can approximate that caused by a slot with the width or a hole with the edge diameter along the tilt direction multiplied by cosine of the tilt angle. The variations of both MMW and IR field distributions were caused by three factors: different tilt angles, air gap thicknesses, and slot widths were analyzed by using AFIM in the spatial domain and the time domain. The simulation results showed that the three factors will affect the uniformity of the MMW field. And the uniformity introduced by the air gap thicknesses was the worst. However, the uniformity still satisfied the requirement for phase error when the variation of the air gap thicknesses was less than 1 mm. Although the three factors would cause the loss of energy and an enhancement in the background noise received by an IR focal plane array, the resolution of the IR system would not be affected. Thus, the WDIT was validated through the above analysis.

  11. Theory of coherent resonance energy transfer

    International Nuclear Information System (INIS)

    Jang, Seogjoo; Cheng, Y.-C.; Reichman, David R.; Eaves, Joel D.

    2008-01-01

    A theory of coherent resonance energy transfer is developed combining the polaron transformation and a time-local quantum master equation formulation, which is valid for arbitrary spectral densities including common modes. The theory contains inhomogeneous terms accounting for nonequilibrium initial preparation effects and elucidates how quantum coherence and nonequilibrium effects manifest themselves in the coherent energy transfer dynamics beyond the weak resonance coupling limit of the Foerster and Dexter (FD) theory. Numerical tests show that quantum coherence can cause significant changes in steady state donor/acceptor populations from those predicted by the FD theory and illustrate delicate cooperation of nonequilibrium and quantum coherence effects on the transient population dynamics.

  12. Coherent Pair Production by Photons in the 20-170 GeV Energy Range Incident on Crystals and Birefringence

    CERN Document Server

    Apyan, A.; Badelek, B.; Ballestrero, S.; Biino, C.; Birol, I.; Cenci, P.; Connell, S.H.; Eichblatt, S.; Fonseca, T.; Freund, A.; Gorini, B.; Groess, R.; Ispirian, K.; Ketel, T.J.; Kononets, Yu.V.; Lopez, A.; Mangiarotti, A.; van Rens, B.; Sellschop, J.P.F.; Shieh, M.; Sona, P.; Strakhovenko, V.; Uggerhoj, E.; Uggerhj, Ulrik Ingerslev; Unel, G.; Velasco, M.; Vilakazi, Z.Z.; Wessely, O.; Kononets, Yu.V.

    2003-01-01

    The cross section for coherent pair production by linearly polarised photons in the 20-170 GeV energy range was measured for photon aligned incidence on ultra-high quality diamond and germanium crystals. The theoretical description of coherent bremsstrahlung and coherent pair production phenomena is an area of active theoretical debate and development. However, under our experimental conditions, the theory predicted the combined cross section and polarisation experimental observables very well indeed. In macroscopic terms, our experiment measured a birefringence effect in pair production in a crystal. This study of this effect also constituted a measurement of the energy dependent linear polarisation of photons produced by coherent bremsstrahlung in aligned crystals. New technologies for manipulating high energy photon beams can be realised based on an improved understanding of QED phenomena at these energies. In particular, this experiment demonstrates an efficient new polarimetry technique. The pair product...

  13. Metaoptics for Spectral and Spatial Beam Manipulation

    Science.gov (United States)

    Raghu Srimathi, Indumathi

    Laser beam combining and beam shaping are two important areas with applications in optical communications, high power lasers, and atmospheric propagation studies. In this dissertation, metaoptical elements have been developed for spectral and spatial beam shaping, and multiplexing. Beams carrying orbital angular momentum (OAM), referred to as optical vortices, have unique propagation properties. Optical vortex beams carrying different topological charges are orthogonal to each other and have low inter-modal crosstalk which allows for them to be (de)multiplexed. Efficient spatial (de)multiplexing of these beams have been carried out by using diffractive optical geometrical coordinate transformation elements. The spatial beam combining technique shown here is advantageous because the efficiency of the system is not dependent on the number of OAM states being combined. The system is capable of generating coaxially propagating beams in the far-field and the beams generated can either be incoherently or coherently multiplexed with applications in power scaling and dynamic intensity profile manipulations. Spectral beam combining can also be achieved with the coordinate transformation elements. The different wavelengths emitted by fiber sources can be spatially overlapped in the far-field plane and the generated beams are Bessel-Gauss in nature with enhanced depth of focus properties. Unique system responses and beam shapes in the far-field can be realized by controlling amplitude, phase, and polarization at the micro-scale. This has been achieved by spatially varying the structural parameters at the subwavelength scale and is analogous to local modification of material properties. With advancements in fabrication technology, it is possible to control not just the lithographic process, but also the deposition process. In this work, a unique combination of spatial structure variations in conjunction with the conformal coating properties of an atomic layer deposition tool

  14. Local characterization of fiber-Bragg gratings through combined use of low-coherence interferometry and a layer-peeling algorithm

    International Nuclear Information System (INIS)

    Chapeleau, Xavier; Leduc, Dominique; Lupi, Cyril; Lopez-Gejo, Francisco; Douay, Marc; Le Ny, Roger; Boisrobert, Christian

    2006-01-01

    The technique presented here allows us to obtain an accurate determination of the refractive index modulation amplitude, the mean effective index, and the chirp of fiber-Bragg gratings. A layer-peeling algorithm is used to extract this information from low-coherence interferometry measurements. Finally, we present a systematic study over 10 uniform and chirped gratings to proof the reliability and accuracy of this technique

  15. Construction of a 100 m3/h demonstration plant in Bad Fischau-Brunn for groundwater remediation by a combined ozone/electron beam irradiation treatment process

    International Nuclear Information System (INIS)

    Gehringer, P.

    1997-06-01

    Groundwater contaminated with about 60 μg/L perchloroethylene (PCE) is purified by a combined ozone/electron beam irradiation process for subsequent use as drinking water. The design of the first commercial plant for such a groundwater remediation having a capacity of 108 m 3 /h is described. The mechanism of the combined ozone/electron beam process for PCE decomposition is discussed with respect to other ozone based advanced oxidation processes like ozone/U.V. and ozone/hydrogen peroxide. The formation of trace amounts of trichloroacetic acid as the only organic by-product in all these processes has been interpreted as an indication that PCE decomposition proceeds via the same mechanism in all cases. (author)

  16. Clinical assessment of 252Californium neutron intracavitary brachytherapy using a two-channel Y applicator combined with external beam radiotherapy for endometrial cancer

    OpenAIRE

    Qian Zhou; Cheng Tang; Ke-Wei Zhao; Yan-Li Xiong; Shu Chen; Wen-Jing Xu; Xin Lei

    2016-01-01

    OBJECTIVE: The aim of this study was to determine the efficacy of 252Californium neutron intracavitary brachytherapy using a two-channel Y applicator combined with external beam radiotherapy for the treatment of endometrial cancer. METHODS: Thirty-one patients with stage I-III endometrial cancer were recruited for this study. The stage I patients received only 252Californium neutron intracavitary brachytherapy with a two-channel applicator. The stage II and III patients received both 252Cali...

  17. Interior tomographic imaging for x-ray coherent scattering (Conference Presentation)

    Science.gov (United States)

    Pang, Sean; Zhu, Zheyuan

    2017-05-01

    Conventional computed tomography reconstructs the attenuation only high-dimensional images. Coherent scatter computed tomography, which reconstructs the angular dependent scattering profiles of 3D objects, can provide molecular signatures that improves the accuracy of material identification and classification. Coherent scatter tomography are traditionally acquired by setups similar to x-ray powder diffraction machine; a collimated source in combination with 2D or 1D detector collimation in order to localize the scattering point. In addition, the coherent scatter cross-section is often 3 orders of magnitude lower than that of the absorption cross-section for the same material. Coded aperture and structured illumination approaches has been shown to greatly improve the collection efficiency. In many applications, especially in security imaging and medical diagnosis, fast and accurate identification of the material composition of a small volume within the whole object would lead to an accelerated imaging procedure and reduced radiation dose. Here, we report an imaging method to reconstruct the material coherent scatter profile within a small volume. The reconstruction along one radial direction can reconstruct a scalar coherent scattering tomographic image. Our methods takes advantage of the finite support of the scattering profile in small angle regime. Our system uses a pencil beam setup without using any detector side collimation. Coherent scatter profile of a 10 mm scattering sample embedded in a 30 mm diameter phantom was reconstructed. The setup has small form factor and is suitable for various portable non-destructive detection applications.

  18. Coherence and Sense of Coherence

    DEFF Research Database (Denmark)

    Dau, Susanne

    2014-01-01

    examined is how activating of models of blended learning in undergraduate education for teacher and radiograph affects the knowledge development. This is approached by mixed methods. The empirical data consist of data from surveys as well as focus group interviews and some observation studies. These data...... are analyzed and interpreted through a critical hermeneutical process of prefiguration, configuration and re-figuration. The findings illustrate significantly importance of sense of coherence among participants as a condition for implementing new designs and new learning environments. It is revealed that sense...

  19. Coherent Bichromatic Force Deflection of Molecules

    Science.gov (United States)

    Kozyryev, Ivan; Baum, Louis; Aldridge, Leland; Yu, Phelan; Eyler, Edward E.; Doyle, John M.

    2018-02-01

    We demonstrate the effect of the coherent optical bichromatic force on a molecule, the polar free radical strontium monohydroxide (SrOH). A dual-frequency retroreflected laser beam addressing the X˜2Σ+↔A˜2Π1 /2 electronic transition coherently imparts momentum onto a cryogenic beam of SrOH. This directional photon exchange creates a bichromatic force that transversely deflects the molecules. By adjusting the relative phase between the forward and counterpropagating laser beams we reverse the direction of the applied force. A momentum transfer of 70 ℏk is achieved with minimal loss of molecules to dark states. Modeling of the bichromatic force is performed via direct numerical solution of the time-dependent density matrix and is compared with experimental observations. Our results open the door to further coherent manipulation of molecular motion, including the efficient optical deceleration of diatomic and polyatomic molecules with complex level structures.

  20. Olfactory Neuroblastoma Treated by Endoscopic Surgery Followed by Combined External Beam Radiation and Gamma Knife for Optic Nerve and Chiasm Sparing: A Case Report

    Directory of Open Access Journals (Sweden)

    Hansi Z. Jiang

    2011-01-01

    Full Text Available We describe the multimodality treatment regimen of a 53-year-old man diagnosed with olfactory neuroblastoma (Kadish stage C in the right nasal cavity extending into the ethmoid sinus and across the cribriform plate. Endoscopic surgery for tumor resection was followed by a combination of external beam radiotherapy and stereotactic radiosurgery boost with concurrent chemotherapy. The novel combination of dual radiation therapies allowed for the preservation of the nearby optic structures while providing an adequate dosage to a sufficient volume of the afflicted tissue.

  1. Operational Performance of LCLS Beam Instrumentation

    International Nuclear Information System (INIS)

    Loos, Henrik; Akre, R.; Brachmann, A.; Coffee, R.; Decker, F.-J.; Ding, Y.; Dowell, D.; Edstrom, S.; Emma, P.; Fisher, A.; Frisch, J.; Gilevich, S.; Hays, G.; Hering, Ph.; Huang, Z.; Iverson, R.; Messerschmidt, M.; Miahnahri, A.; Moeller, S.; Nuhn, H.-D.; Ratner, D.

    2010-01-01

    The Linac Coherent Light Source (LCLS) X-ray FEL utilizing the last km of the SLAC linac has been operational since April 2009 and finished its first successful user run last December. The various diagnostics for electron beam properties including beam position monitors, wire scanners, beam profile monitors, and bunch length diagnostics are presented as well as diagnostics for the X-ray beam. The low emittance and ultra-short electron beam required for X-ray FEL operation has implications on the transverse and longitudinal diagnostics. The coherence effects of the beam profile monitors and the challenges of measuring fs long bunches are discussed.

  2. Operational Performance of LCLS Beam Instrumentation

    Energy Technology Data Exchange (ETDEWEB)

    Loos, Henrik; Akre, R.; Brachmann, A.; Coffee, R.; Decker, F.-J.; Ding, Y.; Dowell, D.; Edstrom, S.; Emma, P.; Fisher, A.; Frisch, J.; Gilevich, S.; Hays, G.; Hering, Ph.; Huang, Z.; Iverson, R.; Messerschmidt, M.; Miahnahri, A.; Moeller, S.; Nuhn, H.-D.; Ratner, D.; /SLAC /LLNL, Livermore

    2010-06-15

    The Linac Coherent Light Source (LCLS) X-ray FEL utilizing the last km of the SLAC linac has been operational since April 2009 and finished its first successful user run last December. The various diagnostics for electron beam properties including beam position monitors, wire scanners, beam profile monitors, and bunch length diagnostics are presented as well as diagnostics for the X-ray beam. The low emittance and ultra-short electron beam required for X-ray FEL operation has implications on the transverse and longitudinal diagnostics. The coherence effects of the beam profile monitors and the challenges of measuring fs long bunches are discussed.

  3. Terascale Beam-Beam Simulations for Tevatron, RHIC and LHC

    Energy Technology Data Exchange (ETDEWEB)

    Qiang, J.

    2005-05-16

    In this paper, we report on recent advances in terascale simulations of the beam-beam interaction in Tevatron, RHIC and LHC.Computational methods for self consistent calculation of beam-beam forces are reviewed. New method for solving the two-dimensional Poisson equation with open boundary conditions is proposed and tested. This new spectral-finite difference method is a factor of four faster than the widely used FFT based Green function method for beam-beam interaction on axis. We also present applications to the study of antiproton losses during the injection stage at Tevatron, to the study of multiple bunch coherent beam-beam modes at RHIC, and to the study of beam-beam driven emittance growth at LHC.

  4. Terascale Beam-Beam Simulations for Tevatron, RHIC and LHC

    International Nuclear Information System (INIS)

    Qiang, J.

    2005-01-01

    In this paper, we report on recent advances in terascale simulations of the beam-beam interaction in Tevatron, RHIC and LHC.Computational methods for self consistent calculation of beam-beam forces are reviewed. New method for solving the two-dimensional Poisson equation with open boundary conditions is proposed and tested. This new spectral-finite difference method is a factor of four faster than the widely used FFT based Green function method for beam-beam interaction on axis. We also present applications to the study of antiproton losses during the injection stage at Tevatron, to the study of multiple bunch coherent beam-beam modes at RHIC, and to the study of beam-beam driven emittance growth at LHC

  5. Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: a combined optical coherence tomography and diffusion tensor imaging study.

    Science.gov (United States)

    Scheel, Michael; Finke, Carsten; Oberwahrenbrock, Timm; Freing, Alina; Pech, Luisa-Maria; Schlichting, Jeremias; Sömmer, Carina; Wuerfel, Jens; Paul, Friedemann; Brandt, Alexander U

    2014-12-01

    We investigated the association of retinal nerve fibre layer thickness (RNFL) with white matter damage assessed by diffusion tensor imaging (DTI). Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography. DTI was analysed with a voxel-based whole brain and region-based analysis of optic radiation, corpus callosum and further white matter. Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls. RNFL correlated with optic radiation FA, but also with corpus callosum and remaining white matter FA. Our findings demonstrate that RNFL changes indicate white matter damage exceeding the visual pathway. © The Author(s), 2014.

  6. A Corotational Finite Element Method Combined with Floating Frame Method for Large Steady-State Deformation and Free Vibration Analysis of a Rotating-Inclined Beam

    Directory of Open Access Journals (Sweden)

    Ming Hsu Tsai

    2011-01-01

    Full Text Available A corotational finite element method combined with floating frame method and a numerical procedure is proposed to investigate large steady-state deformation and infinitesimal-free vibrationaround the steady-state deformation of a rotating-inclined Euler beam at constant angular velocity. The element nodal forces are derived using the consistent second-order linearization of the nonlinear beam theory, the d'Alembert principle, and the virtual work principle in a current inertia element coordinates, which is coincident with a rotating element coordinate system constructed at the current configuration of the beam element. The governing equations for linear vibration are obtained by the first-order Taylor series expansion of the equation of motion at the position of steady-state deformation. Numerical examples are studied to demonstrate the accuracy and efficiency of the proposed method and to investigate the steady-state deformation and natural frequency of the rotating beam with different inclined angle, angular velocities, radius of the hub, and slenderness ratios.

  7. Combined photon-electron beams in the treatment of the supraclavicular lymph nodes in breast cancer: A novel technique that achieves adequate coverage while reducing lung dose.

    Science.gov (United States)

    Salem, Ahmed; Mohamad, Issa; Dayyat, Abdulmajeed; Kanaa'n, Haitham; Sarhan, Nasim; Roujob, Ibrahim; Salem, Abdel-Fattah; Afifi, Shatha; Jaradat, Imad; Mubiden, Rasmi; Almousa, Abdelateif

    2015-01-01

    Radiation pneumonitis is a well-documented side effect of radiation therapy for breast cancer. The purpose of this study was to compare combined photon-electron, photon-only, and electron-only plans in the radiation treatment of the supraclavicular lymph nodes. In total, 13 patients requiring chest wall and supraclavicular nodal irradiation were planned retrospectively using combined photon-electron, photon-only, and electron-only supraclavicular beams. A dose of 50Gy over 25 fractions was prescribed. Chest wall irradiation parameters were fixed for all plans. The goal of this planning effort was to cover 95% of the supraclavicular clinical target volume (CTV) with 95% of the prescribed dose and to minimize the volume receiving ≥ 105% of the dose. Comparative end points were supraclavicular CTV coverage (volume covered by the 95% isodose line), hotspot volume, maximum radiation dose, contralateral breast dose, mean total lung dose, total lung volume percentage receiving at least 20 Gy (V(20 Gy)), heart volume percentage receiving at least 25 Gy (V(25 Gy)). Electron and photon energies ranged from 8 to 18 MeV and 4 to 6 MV, respectively. The ratio of photon-to-electron fractions in combined beams ranged from 5:20 to 15:10. Supraclavicular nodal coverage was highest in photon-only (mean = 96.2 ± 3.5%) followed closely by combined photon-electron (mean = 94.2 ± 2.5%) and lowest in electron-only plans (mean = 81.7 ± 14.8%, p dose was higher in the electron-only (mean = 69.7 ± 56.1 cm(3)) as opposed to combined photon-electron (mean = 50.8 ± 40.9 cm(3)) and photon-only beams (mean = 32.2 ± 28.1 cm(3), p = 0.114). Heart V(25 Gy) was not statistically different among the plans (p = 0.999). Total lung V(20 Gy) was lowest in electron-only (mean = 10.9 ± 2.3%) followed by combined photon-electron (mean = 13.8 ± 2.3%) and highest in photon-only plans (mean = 16.2 ± 3%, p electron-only beams, in terms of decreasing lung dose, is set back by the dosimetric hotspots

  8. Laser Coherence Meter Based on Nanostructured Liquid Crystals

    Directory of Open Access Journals (Sweden)

    A. Anczykowska

    2013-01-01

    Full Text Available We present the method for coherence length measurement using coherence meter based on hybrid liquid crystal structures doped with gold nanoparticles. The results indicate that the method is able to determine the coherence length of coherent light sources with precision of 0.01 m at wavelength range from 200 to 800 nm for wide range of initial beam powers starting from 1 mW. Given the increasing use of laser technology in industry, military, or medicine, our research may open up a possible route for the development of improved techniques of coherent diagnostic light sources.

  9. Spectral-domain optical coherence phase and multiphoton microscopy

    NARCIS (Netherlands)

    Joo, C.; Kim, K.I.; de Boer, J.F.

    2007-01-01

    We describe simultaneous quantitative phase contrast and multiphoton fluorescence imaging by combined spectral-domain optical coherence phase and multiphoton microscopy. The instrument employs two light sources for efficient optical coherence microscopic and multiphoton imaging and can generate

  10. Modes of storage ring coherent instabilities

    International Nuclear Information System (INIS)

    Wang, J.M.

    1986-12-01

    Longitudinal impedance in a beam and various modes of longitudinal coherent instabilities are discussed. The coasting beam coherent instability, microwave instability, and single-bunch longitudinal coherent instabilities are considered. The Vlasov equation is formulated, and a method of solving it is developed. The synchrotron modes are treated, which take the possible bunch shape distortion fully into consideration. A method of treating the synchrotron mode coupling in the case of a small bunch is discussed which takes advantage of the fact that only a few of the synchrotron modes can contribute in such a case. The effect of many bunches on the coherent motion of the beam and the longitudinal symmetric coupled bunch modes are discussed. The transverse impedance is then introduced, and the transverse coasting beam instability is discussed. Various bunched beam instabilities are discussed, including both single bunch instabilities and coupled bunch instabilities. The Vlasov equation for transverse as well as longitudinal motion of particles is introduced as well as a method of solving it within a linear approximation. Head-tail modes and short bunch instabilities and strong coupling instabilities in the long bunch case are covered

  11. Modes of storage ring coherent instabilities

    Energy Technology Data Exchange (ETDEWEB)

    Wang, J.M.

    1986-12-01

    Longitudinal impedance in a beam and various modes of longitudinal coherent instabilities are discussed. The coasting beam coherent instability, microwave instability, and single-bunch longitudinal coherent instabilities are considered. The Vlasov equation is formulated, and a method of solving it is developed. The synchrotron modes are treated, which take the possible bunch shape distortion fully into consideration. A method of treating the synchrotron mode coupling in the case of a small bunch is discussed which takes advantage of the fact that only a few of the synchrotron modes can contribute in such a case. The effect of many bunches on the coherent motion of the beam and the longitudinal symmetric coupled bunch modes are discussed. The transverse impedance is then introduced, and the transverse coasting beam instability is discussed. Various bunched beam instabilities are discussed, including both single bunch instabilities and coupled bunch instabilities. The Vlasov equation for transverse as well as longitudinal motion of particles is introduced as well as a method of solving it within a linear approximation. Head-tail modes and short bunch instabilities and strong coupling instabilities in the long bunch case are covered. (LEW)

  12. Comparison between Experimental and 3D Finite Element Analysis of Reinforced and Partially Pre-Stressed Concrete Solid Beams Subjected to Combined Load of Bending, Torsion and Shear

    Directory of Open Access Journals (Sweden)

    A. S. Alnuaimi

    2008-12-01

    Full Text Available This paper presents a non-linear analysis of three reinforced and two partially prestressed concrete solid beams based on a 20 node isoparametric element using an in-house 3D finite element program. Anon linear elastic isotropic model, proposed by Kotsovos, was used to model concrete behaviour, while steel was modelled as an embedded element exhibiting elastic-perfectly plastic response. Allowance was made for shear retention and for tension stiffening in concrete after cracking. Only in a fixed direction, smeared cracking modelling was adopted. The beams dimensions were 300x300 mm cross section, 3800 mm length and were subjected to combined bending, torsion and shear. Experimental results were compared with the non-linear predictions. The comparison was judged by load displacement relationship, steel strain, angle of twist, failure load, crack pattern and mode of failure. Good agreement was observed between the predicted ultimate load and the experimentally measured loads. It was concluded that the present program can confidently be used to predict the behaviour and failure load of reinforced and partially prestressed concrete solid beams subjected to a combined load of bending, torsion and shear.

  13. Computation of beam quality parameters for Mo/Mo, Mo/Rh, Rh/Rh, and W/Al target/filter combinations in mammography

    International Nuclear Information System (INIS)

    Kharrati, Hedi; Zarrad, Boubaker

    2003-01-01

    A computer program was implemented to predict mammography x-ray beam parameters in the range 20-40 kV for Mo/Mo, Mo/Rh, Rh/Rh, and W/Al target/filter combinations. The computation method used to simulate mammography x-ray spectra is based on the Boone et al. model. The beam quality parameters such as the half-value layer (HVL), the homogeneity coefficient (HC), and the average photon energy were computed by simulating the interaction of the spectrum photons with matter. The checking of this computation was done using a comparison of the results with published data and measured values obtained at the Netherlands Metrology Institute Van Swinden Laboratorium, National Institute of Standards and Technology, and International Atomic Energy Agency. The predicted values with a mean deviation of 3.3% of HVL, 3.7% of HC, and 1.5% of average photon energy show acceptable agreement with published data and measurements for all target/filter combinations in the 23-40 kV range. The accuracy of this computation can be considered clinically acceptable and can allow an appreciable estimation for the beam quality parameters

  14. Combined thermochemical treatment and electron beam treatment of weld edges. Final report; Kombination einer thermochemischen Behandlung mit einer Elektronenstrahl-Randschichtbehandlung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Zenker, R. [Ratoma Consulting-Engineering GmbH-ETC, Chemnitz (Germany); Spies, H.J. [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Werkstofftechnik; Finkbeiner, S. [Arburg Maschinenfabrik Hehl und Soehne GmbH und Co. KG, Lossburg (Germany)

    1996-01-01

    A process for generating weld edges of high abrasive strength was developed. It is a combination of two processes: Nitration - electron beam hardening and boration - electron beam hardening. Experiments were made on the steels X155CrVMo12 1 (1 2379) and X220CrVMo13 4 (1 2380). Further experiments were made on steel 39 CrMoV13 9 (1.8523) as reference steel. (orig./MM) [Deutsch] Das Ziel des Vorhabens bestand in der Erzeugung von Randschichten hoher Verschleissbestaendigkeit durch die Verfahrenskombinationen Nitrieren - Elektronenstrahlhaerten (N+ESH) und Borieren - Elektronenstrahlhaerten (B+ESH). Fuer die Versuche wurden die Staehle X155CrVMo12 1 (1.2379) und X220CrVMo13 4 (1.2380) ausgewaehlt. Untersuchungen an dem Stahl 39CrMoV13 9 (1.8523) dienten Vergleichszwecken. (orig./MM)

  15. Coherent optical communication detection device based on modified balanced optical phase-locked loop

    Science.gov (United States)

    Zhang, Bo; Sun, Jianfeng; Xu, Mengmeng; Li, Guangyuan; Zhang, Guo; Lao, Chenzhe; He, Hongyu; Lu, Zhiyong

    2017-08-01

    In the field of satellite communication, space laser communication technology is famous for its high communication rate, good confidentiality, small size, low power consumption and so on. The design of coherent optical communication detection device based on modified balanced optical phase-locked loop (OPLL) is presented in the paper. It combined by local oscillator beam, modulator, voltage controlled oscillator, signal beam, optical filter, 180 degree hybrid, balanced detector, loop filter and signal receiver. Local oscillator beam and voltage controlled oscillator trace the phase variation of signal beam simultaneously. That taking the advantage of voltage controlled oscillator which responses sensitively and tunable local oscillator laser source with large tuning range can trace the phase variation of signal beam rapidly and achieve phase locking. The demand of the phase deviation is very low, and the system is easy to adjust. When the transmitter transmits the binary phase shift keying (BPSK) signal, the receiver can demodulate the baseband signal quickly, which has important significance for the free space coherent laser communication.

  16. Numerical simulations on conformable laser-induced interstitial thermotherapy through combined use of multi-beam heating and biodegradable nanoparticles.

    Science.gov (United States)

    Zhang, Jie; Jin, Chao; He, Zhi-Zhu; Liu, Jing

    2014-07-01

    Clinically, precisely heating and thus completely ablating diseased tumor tissue through laser beam is still facing many technical challenges. In this study, numerical simulation of a conformal heating modality based on multi-beam laser along with biodegradable magnesium nanoparticles (Mg-NPs) was put forward to treat liver tumor with large size or irregular shape. Further, a Gaussian-like distribution was proposed to investigate the influence of Mg-NP deposition on the nanoenhanced laser-induced interstitial thermotherapy (LITT). A temperature feedback system was adopted to control the temperature range to avoid overheating. To preliminarily validate the heating enhancement induced by the applied multi-beam laser and Mg-NPs, a conceptual experiment was performed. Both theoretical simulation and experimental measurements demonstrated that multi-beam laser with Mg-NPs could improve efficiency in the conformal heating of tumors with irregular shape or large size. In addition, the distribution and content of Mg-NPs produced significant impact on thermotherapy: (1) The adjustable parameter σ in the Gaussian-like distribution could reflect various practical situations and diffusivities of Mg-NPs; (2) under the premise of the same concentration of Mg-NPs and short time to heat a small-sized target, the whole liver tumor containing Mg-NPs could not improve the efficiency as the nanoparticles limited the photons to be absorbed only around the fibers, while liver tumor partially containing Mg-NPs could improve the thermotherapy efficiency up to 20 %; and (3) the addition of Mg-NPs was rather beneficial for realizing a conformal heating as the residual thermal energy was much less than that without Mg-NPs. This study suggests a feasible and promising modality for planning a high-performance LITT in future clinics.

  17. Diffusion filter eliminates fringe effects of coherent laser light source

    Science.gov (United States)

    Olsasky, M. J.

    1970-01-01

    Diffusion filter comprised of small particles in colloidal suspension reduces the coherence of a laser beam used as a photographic light source. Interference patterns which obscure details in photographic film are eliminated, the intensity and collimation are moderately affected.

  18. Coherent compounding in doppler imaging.

    Science.gov (United States)

    Ekroll, Ingvild K; Voormolen, Marco M; Standal, Oyvind K-V; Rau, Jochen M; Lovstakken, Lasse

    2015-09-01

    Coherent compounding can provide high frame rates and wide regions of interest for imaging of blood flow. However, motion will cause out-of-phase summation, potentially causing image degradation. In this work the impact of blood motion on SNR and the accuracy of Doppler velocity estimates are investigated. A simplified model for the compounded Doppler signal is proposed. The model is used to show that coherent compounding acts as a low-pass filter on the coherent compounding Doppler signal, resulting in negatively biased velocity estimates. Simulations and flow phantom experiments are used to quantify the bias and Doppler SNR for different velocities and beam-to-flow (BTF) angles. It is shown that the bias in the mean velocity increases with increasing beam-to-flow angle and/or blood velocity, whereas the SNR decreases; losses up to 4 dB were observed in the investigated scenarios. Further, a 2-D motion correction scheme is proposed based on multi-angle vector Doppler velocity estimates. For a velocity of 1.1 v(Nyq) and a BTF angle of 75°, the bias was reduced from 30% to less than 4% in simulations. The motion correction scheme was also applied to flow phantom and in vivo recordings, in both cases resulting in a substantially reduced mean velocity bias and an SNR less dependent on blood velocity and direction.

  19. Beam geometry selection using sequential beam addition.

    Science.gov (United States)

    Popple, Richard A; Brezovich, Ivan A; Fiveash, John B

    2014-05-01

    The selection of optimal beam geometry has been of interest since the inception of conformal radiotherapy. The authors report on sequential beam addition, a simple beam geometry selection method, for intensity modulated radiation therapy. The sequential beam addition algorithm (SBA) requires definition of an objective function (score) and a set of candidate beam geometries (pool). In the first iteration, the optimal score is determined for each beam in the pool and the beam with the best score selected. In the next iteration, the optimal score is calculated for each beam remaining in the pool combined with the beam selected in the first iteration, and the best scoring beam is selected. The process is repeated until the desired number of beams is reached. The authors selected three treatment sites, breast, lung, and brain, and determined beam arrangements for up to 11 beams from a pool comprised of 25 equiangular transverse beams. For the brain, arrangements were additionally selected from a pool of 22 noncoplanar beams. Scores were determined for geometries comprised equiangular transverse beams (EQA), as well as two tangential beams for the breast case. In all cases, SBA resulted in scores superior to EQA. The breast case had the strongest dependence on beam geometry, for which only the 7-beam EQA geometry had a score better than the two tangential beams, whereas all SBA geometries with more than two beams were superior. In the lung case, EQA and SBA scores monotonically improved with increasing number of beams; however, SBA required fewer beams to achieve scores equivalent to EQA. For the brain case, SBA with a coplanar pool was equivalent to EQA, while the noncoplanar pool resulted in slightly better scores; however, the dose-volume histograms demonstrated that the differences were not clinically significant. For situations in which beam geometry has a significant effect on the objective function, SBA can identify arrangements equivalent to equiangular

  20. Beam geometry selection using sequential beam addition

    Energy Technology Data Exchange (ETDEWEB)

    Popple, Richard A., E-mail: rpopple@uabmc.edu; Brezovich, Ivan A.; Fiveash, John B. [Department of Radiation Oncology, The University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, Alabama 35294 (United States)

    2014-05-15

    Purpose: The selection of optimal beam geometry has been of interest since the inception of conformal radiotherapy. The authors report on sequential beam addition, a simple beam geometry selection method, for intensity modulated radiation therapy. Methods: The sequential beam addition algorithm (SBA) requires definition of an objective function (score) and a set of candidate beam geometries (pool). In the first iteration, the optimal score is determined for each beam in the pool and the beam with the best score selected. In the next iteration, the optimal score is calculated for each beam remaining in the pool combined with the beam selected in the first iteration, and the best scoring beam is selected. The process is repeated until the desired number of beams is reached. The authors selected three treatment sites, breast, lung, and brain, and determined beam arrangements for up to 11 beams from a pool comprised of 25 equiangular transverse beams. For the brain, arrangements were additionally selected from a pool of 22 noncoplanar beams. Scores were determined for geometries comprised equiangular transverse beams (EQA), as well as two tangential beams for the breast case. Results: In all cases, SBA resulted in scores superior to EQA. The breast case had the strongest dependence on beam geometry, for which only the 7-beam EQA geometry had a score better than the two tangential beams, whereas all SBA geometries with more than two beams were superior. In the lung case, EQA and SBA scores monotonically improved with increasing number of beams; however, SBA required fewer beams to achieve scores equivalent to EQA. For the brain case, SBA with a coplanar pool was equivalent to EQA, while the noncoplanar pool resulted in slightly better scores; however, the dose-volume histograms demonstrated that the differences were not clinically significant. Conclusions: For situations in which beam geometry has a significant effect on the objective function, SBA can identify

  1. OBSERVATION OF STRONG - STRONG AND OTHER BEAM - BEAM EFFECTS IN RHIC

    International Nuclear Information System (INIS)

    FISCHER, W.; BLASKIEWICZ, M.; BRENNAN, J.M.; CAMERON, P.; CONNOLLY, R.; MONTAG, C.; PEGGS, S.; PILAT, F.; PTITSYN, V.; TEPIKIAN, S.; TRBOJEVIC, D.; VAN ZEIJTS, J.

    2003-01-01

    RHIC is currently the only hadron collider in which strong-strong beam-beam effects can be seen. For the first time, coherent beam-beam modes were observed in a bunched beam hadron collider. Other beam-beam effects in RHIC were observed in operation and in dedicated experiments with gold ions, deuterons and protons. Observations include measurements of beam-beam induced tune shifts, lifetime and emittance growth measurements with and without beam-beam interaction, and background rates as a function of tunes. During ramps unequal radio frequencies in the two rings cause the crossing points to move longitudinally. Thus bunches experience beam-beam interactions only in intervals and the tunes are modulated. In this article we summarize the most important beam-beam observations made so far

  2. Clinical assessment of 252Californium neutron intracavitary brachytherapy using a two-channel Y applicator combined with external beam radiotherapy for endometrial cancer

    Directory of Open Access Journals (Sweden)

    Qian Zhou

    2016-01-01

    Full Text Available OBJECTIVE: The aim of this study was to determine the efficacy of 252Californium neutron intracavitary brachytherapy using a two-channel Y applicator combined with external beam radiotherapy for the treatment of endometrial cancer. METHODS: Thirty-one patients with stage I-III endometrial cancer were recruited for this study. The stage I patients received only 252Californium neutron intracavitary brachytherapy with a two-channel applicator. The stage II and III patients received both 252Californium neutron intracavitary brachytherapy using a two-channel applicator and parallel-opposed whole pelvic radiotherapy. RESULTS: The five-year local control rate was 80.6% (25/31, the overall survival rate was 51.6% (16/31, and the disease-free survival rate was 54.8% (17/31. The incidence of serious late complications was 12.9% (4/31. CONCLUSIONS: 252Californium neutron intracavitary brachytherapy using a two-channel applicator combined with external beam radiotherapy was effective for treating endometrial cancer and the incidence of serious late complications related to this combination was within an acceptable range.

  3. Water window ptychographic imaging with characterized coherent X-rays

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Max [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg (Germany); Skopintsev, Petr [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg (Germany); Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region 141700 (Russian Federation); Dzhigaev, Dmitry [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg (Germany); National Research Nuclear University ‘MEPhI’ (Moscow Engineering Physics Institute), Kashirskoe shosse 31, 115409 Moscow (Russian Federation); Gorobtsov, Oleg [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg (Germany); National Research Center, ‘Kurchatov Institute’, Kurchatov Square 1, 123182 Moscow (Russian Federation); Senkbeil, Tobias; Gundlach, Andreas von; Gorniak, Thomas [Analytical Chemistry - Biointerfaces, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum (Germany); Applied Physical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120 Heidelberg (Germany); Institute of Functional Interfaces, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen (Germany); Shabalin, Anatoly; Viefhaus, Jens [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg (Germany); Rosenhahn, Axel, E-mail: axel.rosenhahn@rub.de [Analytical Chemistry - Biointerfaces, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum (Germany); Applied Physical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, 69120 Heidelberg (Germany); Institute of Functional Interfaces, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen (Germany); Vartanyants, Ivan, E-mail: axel.rosenhahn@rub.de [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg (Germany); National Research Nuclear University ‘MEPhI’ (Moscow Engineering Physics Institute), Kashirskoe shosse 31, 115409 Moscow (Russian Federation)

    2015-04-23

    Water window ptychographic coherent diffractive imaging was demonstrated at the P04 beamline of PETRA III synchrotron radiation source. The beam coherence was characterized with the non-redundant array method. A ptychographical coherent diffractive imaging experiment in the water window with focused soft X-rays at 500 eV is reported. An X-ray beam with high degree of coherence was selected for ptychography at the P04 beamline of PETRA III synchrotron radiation source. The beam coherence was measured with the newly developed non-redundant array method, and a coherence length of 4.1 µm and global degree of coherence of 35% at 100 µm exit slit opening in the vertical direction were determined. A pinhole, 2.6 µm in size, selected the coherent part of the beam that was used to obtain ptychographic reconstruction results of a lithographically manufactured test sample and a fossil diatom. The achieved resolution was 53 nm for the test sample and was only limited by the size of the detector. The diatom was imaged at a resolution better than 90 nm.

  4. Coherent artifact suppression in line-field reflection confocal microscopy using a low spatial coherence light source.

    Science.gov (United States)

    Liu, Changgeng; Cao, Hui; Choma, Michael A

    2016-10-15

    Line-field reflection confocal microscopy (LF-RCM) has the potential to add a dimension of parallelization to traditional confocal microscopy while reducing the need for two-axis beam scanning. LF-RCM systems often employ light sources with a high degree of spatial coherence. This high degree of spatial coherence potentially leads to unwanted coherent artifact in the setting of nontrivial sample scattering. Here, we (a) confirm that a coherent artifact is a nontrivial problem in LF-RCM when using spatially coherent light, and (b) demonstrate that such a coherent artifact can be mitigated through the use of reduced spatial coherence line-field sources. We demonstrate coherent noise suppression in a full-pupil line-field confocal microscope using a large number of mutually incoherent emitters from a vertical-cavity surface-emitting lasers (VCSEL) array. The coherent noise from a highly scattering sample is significantly suppressed by the use of this synthesized reduced spatial coherence light source compared to a fully coherent light source. Lastly, with scattering samples, the axial confocality of line-field confocal microscopy is compromised independent of the source spatial coherence, as demonstrated by our experimental result. Our results highlight the importance of spatial coherence engineering in parallelized reflection confocal microscopy.

  5. Colloquium: Quantum coherence as a resource

    Science.gov (United States)

    Streltsov, Alexander; Adesso, Gerardo; Plenio, Martin B.

    2017-10-01

    The coherent superposition of states, in combination with the quantization of observables, represents one of the most fundamental features that mark the departure of quantum mechanics from the classical realm. Quantum coherence in many-body systems embodies the essence of entanglement and is an essential ingredient for a plethora of physical phenomena in quantum optics, quantum information, solid state physics, and nanoscale thermodynamics. In recent years, research on the presence and functional role of quantum coherence in biological systems has also attracted considerable interest. Despite the fundamental importance of quantum coherence, the development of a rigorous theory of quantum coherence as a physical resource has been initiated only recently. This Colloquium discusses and reviews the development of this rapidly growing research field that encompasses the characterization, quantification, manipulation, dynamical evolution, and operational application of quantum coherence.

  6. ZnTe-ZnO core-shell radial heterostructures grown by the combination of molecular beam epitaxy and atomic layer deposition.

    Science.gov (United States)

    Janik, E; Wachnicka, A; Guziewicz, E; Godlewski, M; Kret, S; Zaleszczyk, W; Dynowska, E; Presz, A; Karczewski, G; Wojtowicz, T

    2010-01-08

    ZnTe-ZnO core-shell radial heterostructures were grown using a new method of combining molecular beam epitaxy (MBE) and atomic layer deposition (ALD). Zinc telluride nanowires (core) were grown on a GaAs substrate using gold catalyzed vapor-liquid-solid mechanism. An atomic layer deposition technique using diethyl zinc and deionized water as precursors was applied for zinc oxide shell formation. The core-shell ZnTe-ZnO heterostructures thus obtained were characterized by scanning electron microscopy, transmission electron microscopy, x-ray diffraction and photoluminescence measurements.

  7. Evaluation of the structure of amorphous tungsten oxide W28O72 by the combination of electron-, X-ray- and neutron-diffraction (three-beam experiment)

    International Nuclear Information System (INIS)

    Ankele, J.; Mayer, J.

    2006-01-01

    From the combination of quantitative electron-diffraction data with X-ray- and neutron-diffraction data (so-called three-beam experiment) the partial structure factors and pair correlation functions of amorphous sputter deposited W 28 O 72 were determined. On the basis of the experimental atomic distances and coordination numbers, and by comparison with crystalline WO 3 , a structural model was developed, which consists of twisted WO 6 octahedra. Reverse Monte Carlo simulation in accordance with the experimental data was performed to verify the results. (orig.)

  8. Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute

    OpenAIRE

    Janulionis, Ernestas; Valuckas, Konstantinas Povilas; Liukpetryte, Sarune; Samerdokiene, Vitalija; Atkocius, Vydmantas

    2015-01-01

    Purpose The purpose of this paper was to observe and compare long-term curative effects and complications of FIGO stage IIB cervical cancer patients (n = 232) treated with high-dose-rate (HDR) californium (252Cf) neutron or cobalt (60Co) photon intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT). Material and methods The EBRT dose to the small pelvis was 50 Gy in both groups. The brachytherapy component of 252Cf or 60Co was added in the 3rd week of EBRT, 5 fract...

  9. Three-dimensional high dose rate dosimetry of electron beams. A combined radiochromic film, EPR and calorimetric dosimetry

    International Nuclear Information System (INIS)

    Secerov, B.; Milosavljevic, B.H.; Bacic, G.; Belgrade Univ.

    2002-01-01

    Complete text of publication follows. Aim. To examine the suitability of radiochromic film (RCF) dosimeters in determining 3D dose distribution from a pulsed electron beam source by comparing their response with alanine EPR dosimetry and calorimetry. Experimental. A FWT-60 radiochromic films (Far West Technology Inc) were used while alanine films were home made. To obtain the dose vs. penetration depth relationship, a stack of 13 films separated by aluminium plates and/or alanine films was placed perpendicular to the electron beam (Febetron, 20 ns, 1.8 MeV, 10 12 Gy/s, dose range up to 100 kGy). RC films were calibrated using 60-Co source and Fricke dosimetry. The absorbance of irradiated films was measured using 2D microdensitometry. Calorimetry was performed with a homemade quasy-adiabatic aluminum calorimeter. Results and Discussion. Microdensitometry of films (5 x 5 cm) enabled the 3D mapping of the entire radiation field with in plane resolution of 0.12 mm. The total dose for each film was obtained by image segmentation to correct for the non-linear response of films. Integrated dose for the entire stack was in good agreement (within 5%) with total absorbed energy as determined with calorimetry. The dose distribution along the beam center was determined using alanine films (1 x 1 cm) and EPR spectroscopy, and again a good agreement with the dose determined by microdensitometry of the central portion of RC films. In conclusion, the results indicate that RC films can be used for determination of 3D dose distribution even at very high dose rates

  10. A Treatment Planning Comparison of Combined Photon-Proton Beams Versus Proton Beams-Only for the Treatment of Skull Base Tumors

    International Nuclear Information System (INIS)

    Feuvret, Loic; Noel, Georges; Weber, Damien C.; Pommier, Pascal; Ferrand, Regis; De Marzi, Ludovic; Dhermain, Frederic; Alapetite, Claire; Mammar, Hamid; Boisserie, Gilbert; Habrand, Jean-Louis; Mazeron, Jean-Jacques

    2007-01-01

    Purpose: To compare treatment planning between combined photon-proton planning (CP) and proton planning (PP) for skull base tumors, so as to assess the potential limitations of CP for these tumors. Methods and Materials: Plans for 10 patients were computed for both CP and PP. Prescribed dose was 67 cobalt Gray equivalent (CGE) for PP; 45 Gy (photons) and 22 CGE (protons) for CP. Dose-volume histograms (DVHs) were calculated for gross target volume (GTV), clinical target volume (CTV), normal tissues (NT), and organs at risk (OARs) for each plan. Results were analyzed using DVH parameters, inhomogeneity coefficient (IC), and conformity index (CI). Results: Mean doses delivered to the GTVs and CTVs with CP (65.0 and 61.7 CGE) and PP (65.3 and 62.2 Gy CGE) were not significantly different (p > 0.1 and p = 0.72). However, the dose inhomogeneity was drastically increased with CP, with a mean significant incremental IC value of 10.5% and CP of 6.8%, for both the GTV (p = 0.01) and CTV (p = 0.04), respectively. The CI 80% values for the GTV and CTV were significantly higher with PP compared with CP. Compared with CP, the use of protons only led to a significant reduction of NT and OAR irradiation, in the intermediate-to-low dose (≤80% isodose line) range. Conclusions: These results suggest that the use of CP results in levels of target dose conformation similar to those with PP. Use of PP significantly reduced the tumor dose inhomogeneity and the delivered intermediate-to-low dose to NT and OARs, leading us to conclude that this treatment is mainly appropriate for tumors in children

  11. SU-G-JeP1-01: A Combination of Real Time Electromagnetic Localization and Tracking with Cone Beam Computed Tomography in Stereotactic Radiosurgery for Brain Tumors

    Energy Technology Data Exchange (ETDEWEB)

    Muralidhar, K Raja; Pangam, Suresh; Ponaganti, Srinivas; Krishna, Jayarama; Sujana, Kolla V; Komanduri, Priya K [American Oncology Institute, Hyderabad, Telangana (India)

    2016-06-15

    Purpose: 1. online verification of patient position during treatment using calypso electromagnetic localization and tracking system. 2. Verification and comparison of positional accuracy between cone beam computed tomography and calypso system. 3. Presenting the advantage of continuation localization in Stereotactic radiosurgery treatments. Methods: Ten brain tumor cases were taken for this study. Patients with head mask were under gone Computed Tomography (CT). Before scanning, mask was cut on the fore head area to keep surface beacons on the skin. Slice thickness of 0.65 mm were taken for this study. x, y, z coordinates of these beacons in TPS were entered into tracking station. Varian True Beam accelerator, equipped with On Board Imager was used to take Cone beam Computed Tomography (CBCT) to localize the patient. Simultaneously Surface beacons were used to localize and track the patient throughout the treatment. The localization values were compared in both systems. For localization CBCT considered as reference. Tracking was done throughout the treatment using Calypso tracking system using electromagnetic array. This array was in tracking position during imaging and treatment. Flattening Filter free beams of 6MV photons along with Volumetric Modulated Arc Therapy was used for the treatment. The patient movement was observed throughout the treatment ranging from 2 min to 4 min. Results: The average variation observed between calypso system and CBCT localization was less than 0.5 mm. These variations were due to manual errors while keeping beacon on the patient. Less than 0.05 cm intra-fraction motion was observed throughout the treatment with the help of continuous tracking. Conclusion: Calypso target localization system is one of the finest tools to perform radiosurgery in combination with CBCT. This non radiographic method of tracking is a real beneficial method to treat patients confidently while observing real-time motion information of the patient.

  12. A combined molecular dynamics and Monte Carlo simulation of the spatial distribution of energy deposition by proton beams in liquid water

    International Nuclear Information System (INIS)

    Garcia-Molina, Rafael; Abril, Isabel; Heredia-Avalos, Santiago; Kyriakou, Ioanna; Emfietzoglou, Dimitris

    2011-01-01

    We have evaluated the spatial distribution of energy deposition by proton beams in liquid water using the simulation code SEICS (Simulation of Energetic Ions and Clusters through Solids), which combines molecular dynamics and Monte Carlo techniques and includes the main interaction phenomena between the projectile and the target constituents: (i) the electronic stopping force due to energy loss to target electronic excitations, including fluctuations due to the energy-loss straggling, (ii) the elastic scattering with the target nuclei, with their corresponding energy loss and (iii) the dynamical changes in projectile charge state due to electronic capture and loss processes. An important feature of SEICS is the accurate account of the excitation spectrum of liquid water, based on a consistent solid-state description of its energy-loss-function over the whole energy and momentum space. We analyse how the above-mentioned interactions affect the depth distribution of the energy delivered in liquid water by proton beams with incident energies of the order of several MeV. Our simulations show that the position of the Bragg peak is determined mainly by the stopping power, whereas its width can be attributed to the energy-loss straggling. Multiple elastic scattering processes contribute slightly only at the distal part of the Bragg peak. The charge state of the projectiles only changes when approaching the end of their trajectories, i.e. near the Bragg peak. We have also simulated the proton-beam energy distribution at several depths in the liquid water target, and found that it is determined mainly by the fluctuation in the energy loss of the projectile, evaluated through the energy-loss straggling. We conclude that a proper description of the target excitation spectrum as well as the inclusion of the energy-loss straggling is essential in the calculation of the proton beam depth-dose distribution.

  13. The Relationships of the Maxillary Sinus With the Superior Alveolar Nerves and Vessels as Demonstrated by Cone-Beam CT Combined With μ-CT and Histological Analyses.

    Science.gov (United States)

    Kasahara, Norio; Morita, Wataru; Tanaka, Ray; Hayashi, Takafumi; Kenmotsu, Shinichi; Ohshima, Hayato

    2016-05-01

    There are no available detailed data on the three-dimensional courses of the human superior alveolar nerves and vessels. This study aimed to clarify the relationships of the maxillary sinus with the superior alveolar nerves and vessels using cone-beam computed tomography (CT) combined with μ-CT and histological analyses. Digital imaging and communication in medicine data obtained from the scanned heads/maxillae of cadavers used for undergraduate/postgraduate dissection practice and skulls using cone-beam CT were reconstructed into three-dimensional (3D) images using software. The 3D images were compared with μ-CT images and histological sections. Cone-beam CT clarified the relationships of the maxillary sinus with the superior alveolar canals/grooves. The main anterior superior alveolar canal/groove ran anteriorly through the upper part of the sinus and terminated at the bottom of the nasal cavity near the piriform aperture. The main middle alveolar canal ran downward from the upper part of the sinus to ultimately join the anterior one. The main posterior alveolar canal ran through the lateral lower part of the sinus and communicated with the anterior one. Histological analyses demonstrated the existence of nerves and vessels in these canals/grooves, and the quantities of these structures varied across each canal/groove. Furthermore, the superior dental nerve plexus exhibited a network that was located horizontally to the occlusal plane, although these nerve plexuses appeared to be the vertical network that is described in most textbooks. In conclusion, cone-beam CT is suggested to be a useful method for clarifying the superior alveolar canals/grooves including the nerves and vessels. © 2016 Wiley Periodicals, Inc.

  14. Polarization fluctuations in stationary light beams

    International Nuclear Information System (INIS)

    Shevchenko, A.; Setaelae, T.; Kaivola, M.; Friberg, A.T.; Royal Institute of Technology , Department of Microelectronics and Applied Physics; Sweden)

    2009-01-01

    For stationary beams the degree of polarization contains only limited information on time dependent polarization. Two approaches towards assessing a beams polarization dynamics, one based on Poincare and the other on Jones vector formalism, are described leading to the notion of polarization time. Specific examples of partially temporally coherent electromagnetic beams are discussed. (Author)

  15. Arrays of suspended silicon nanowires defined by ion beam implantation: mechanical coupling and combination with CMOS technology

    Science.gov (United States)

    Llobet, J.; Rius, G.; Chuquitarqui, A.; Borrisé, X.; Koops, R.; van Veghel, M.; Perez-Murano, F.

    2018-04-01

    We present the fabrication, operation, and CMOS integration of arrays of suspended silicon nanowires (SiNWs). The functional structures are obtained by a top-down fabrication approach consisting in a resistless process based on focused ion beam irradiation, causing local gallium implantation and silicon amorphization, plus selective silicon etching by tetramethylammonium hydroxide, and a thermal annealing process in a boron rich atmosphere. The last step enables the electrical functionality of the irradiated material. Doubly clamped silicon beams are fabricated by this method. The electrical readout of their mechanical response can be addressed by a frequency down-mixing detection technique thanks to an enhanced piezoresistive transduction mechanism. Three specific aspects are discussed: (i) the engineering of mechanically coupled SiNWs, by making use of the nanometer scale overhang that it is inherently-generated with this fabrication process, (ii) the statistical distribution of patterned lateral dimensions when fabricating large arrays of identical devices, and (iii) the compatibility of the patterning methodology with CMOS circuits. Our results suggest that the application of this method to the integration of large arrays of suspended SiNWs with CMOS circuitry is interesting in view of applications such as advanced radio frequency band pass filters and ultra-high-sensitivity mass sensors.

  16. A combined crossed molecular beams and theoretical study of the reaction CN + C{sub 2}H{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Balucani, Nadia, E-mail: nadia.balucani@unipg.it [Dipartimento di Chimica, Biologia e Biotecnologie, Università degli Studi di Perugia, Perugia (Italy); Leonori, Francesca; Petrucci, Raffaele [Dipartimento di Chimica, Biologia e Biotecnologie, Università degli Studi di Perugia, Perugia (Italy); Wang, Xingan [Dipartimento di Chimica, Biologia e Biotecnologie, Università degli Studi di Perugia, Perugia (Italy); Department of Chemical Physics, University of Science and Technology of China, Hefei 230026 (China); Casavecchia, Piergiorgio [Dipartimento di Chimica, Biologia e Biotecnologie, Università degli Studi di Perugia, Perugia (Italy); Skouteris, Dimitrios [Scuola Normale Superiore, Pisa (Italy); Albernaz, Alessandra F. [Instituto de Física, Universidade de Brasília, Brasília (Brazil); Gargano, Ricardo [Instituto de Física, Universidade de Brasília, Brasília (Brazil); Departments of Chemistry and Physics, University of Florida, Quantum Theory Project, Gainesville, FL 32611 (United States)

    2015-03-01

    Highlights: • The CN + C{sub 2}H{sub 4} reaction was investigated in crossed beam experiments. • Electronic structure calculations of the potential energy surface were performed. • RRKM estimates qualitatively reproduce the experimental C{sub 2}H{sub 3}NC yield. - Abstract: The CN + C{sub 2}H{sub 4} reaction has been investigated experimentally, in crossed molecular beam (CMB) experiments at the collision energy of 33.4 kJ/mol, and theoretically, by electronic structure calculations of the relevant potential energy surface and Rice–Ramsperger–Kassel–Marcus (RRKM) estimates of the product branching ratio. Differently from previous CMB experiments at lower collision energies, but similarly to a high energy study, we have some indication that a second reaction channel is open at this collision energy, the characteristics of which are consistent with the channel leading to CH{sub 2}CHNC + H. The RRKM estimates using M06L electronic structure calculations qualitatively support the experimental observation of C{sub 2}H{sub 3}NC formation at this and at the higher collision energy of 42.7 kJ/mol of previous experiments.

  17. Improving 4D plan quality for PBS-based liver tumour treatments by combining online image guided beam gating with rescanning

    Science.gov (United States)

    Zhang, Ye; Knopf, Antje-Christin; Weber, Damien Charles; Lomax, Antony John

    2015-10-01

    Pencil beam scanned (PBS) proton therapy has many advantages over conventional radiotherapy, but its effectiveness for treating mobile tumours remains questionable. Gating dose delivery to the breathing pattern is a well-developed method in conventional radiotherapy for mitigating tumour-motion, but its clinical efficiency for PBS proton therapy is not yet well documented. In this study, the dosimetric benefits and the treatment efficiency of beam gating for PBS proton therapy has been comprehensively evaluated. A series of dedicated 4D dose calculations (4DDC) have been performed on 9 different 4DCT(MRI) liver data sets, which give realistic 4DCT extracting motion information from 4DMRI. The value of 4DCT(MRI) is its capability of providing not only patient geometries and deformable breathing characteristics, but also includes variations in the breathing patterns between breathing cycles. In order to monitor target motion and derive a gating signal, we simulate time-resolved beams’ eye view (BEV) x-ray images as an online motion surrogate. 4DDCs have been performed using three amplitude-based gating window sizes (10/5/3 mm) with motion surrogates derived from either pre-implanted fiducial markers or the diaphragm. In addition, gating has also been simulated in combination with up to 19 times rescanning using either volumetric or layered approaches. The quality of the resulting 4DDC plans has been quantified in terms of the plan homogeneity index (HI), total treatment time and duty cycle. Results show that neither beam gating nor rescanning alone can fully retrieve the plan homogeneity of the static reference plan. Especially for variable breathing patterns, reductions of the effective duty cycle to as low as 10% have been observed with the smallest gating rescanning window (3 mm), implying that gating on its own for such cases would result in much longer treatment times. In addition, when rescanning is applied on its own, large differences between volumetric

  18. In situ investigation of the surface silvering of late Roman coins by combined use of high energy broad-beam and low energy micro-beam X-ray fluorescence techniques

    International Nuclear Information System (INIS)

    Romano, F.P.; Garraffo, S.; Pappalardo, L.; Rizzo, F.

    2012-01-01

    The compositional analysis of archeological metals performed with the X-ray Fluorescence technique (XRF) provides information on the ancient technology. One of the most interesting case-study concerns the techniques used by Romans for silvering the surface of coins. Different metallurgical processes have been suggested in previous studies. Recently the investigation has been addressed to the mercury-silvering and to its possible use in the mass-production of coins minted during the late period (after 294 AD). In the present paper the non-destructive investigation of the silvering process used for manufacturing the Roman nummi – the important typology of coin introduced by Diocletian in his monetary reform – is approached by the combined use of the standard X-Ray Fluorescence (XRF) and the low energy micro-X-Ray Fluorescence (LE-μXRF) portable methods. The research was focused on the systematic determination of the mercury presence in a large number of samples and on its correlation with silver in the surface of the coins. 1041 Roman nummi belonging to the Misurata Treasure were analyzed in situ, at the Leptis Magna Museum (Al Khums, Libya). The treasure, composed of about 108 thousand silvered coins, gives the unique opportunity to study the Roman coinage in a wide interval of time (about 40 years in the period 294–333 AD) and in almost all the imperial mints operating in the Roman world. - Highlights: ► Custom-building of a high energy broad-beam and a low energy micro-beam XRF ► In situ analysis of the silvering methods in late Roman nummi with plated surfaces ► The broad-beam XRF was applied for the detection of mercury traces in the coin alloy. ► The low energy micro-XRF was used to scan the surface patina of the coins. ► The correlation between mercury and silver at the coin surface was evidenced.

  19. [Comparative study of radical prostatectomy versus external beam radiotherapy (75.6 Gy) combined with hormone therapy for prostate cancer of intermediate D'Amico risk classification].

    Science.gov (United States)

    Boissier, R; Karsenty, G; Muracciole, X; Daniel, L; Delaporte, V; Maurin, C; Coulange, C; Lechevallier, E

    2013-09-01

    Thirty-three percent of the localized cancers belongs initially to the group of intermediate risk of D'Amico. The standard treatments validated by the French Association of Urology are the radical prostatectomy and the external beam radiotherapy. We retrospectively compared the carcinologic results of the radical prostatectomy±adjuvant treatment (RP) and the external beam radiotherapy combining high dose (75.6 Gy) and short hormonotherapy (RH), in the treatment of intermediate risk prostate cancer. The series consisted of 143 patients treated between 2000 and 2006 in the department of Urology and Kidney transplantation of the Conception Hospital, Marseilles. The main assessment criteria was the survival without biological recurrence (SBR). The median follow-up was 90 months [59-51]. The 5 years and 8 years SBR were 85% and 73% in the RH group, versus 74% and 65% with RP (P=0.196). There was a significant difference between the series: on the age of diagnosis (63.9 versus 73.3 years, P<0.001), the Charlson score of comorbidity (2 versus 3, P<0.001) and the number of intermediate criteria per patients (one intermediate criteria: RP 74% versus 57%, P<0.01). According to our study, there was no superiority of the radical prostatectomy±adjuvant treatment or the external radiotherapy combining high dose and concomitant short hormonotherapy on the survival without biological recurrence at 5 and 8 years. Many studies confirm that a concomitant hormonotherapy increases the carcinologic control, even with a high rate external beam radiotherapy. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  20. Impact of age on quality of life in patients with localized prostate cancer treated with high-dose rate brachytherapy combined with external beam radiotherapy.

    Science.gov (United States)

    Kikkawa, Kazuro; Iba, Akinori; Kohjimoto, Yasuo; Noda, Yasutaka; Sonomura, Tetsuo; Hara, Isao

    2018-02-04

    To evaluate age-related quality of life changes in patients with localized prostate cancer treated by high-dose rate brachytherapy combined with external beam radiation therapy. A total of 172 patients with clinically localized prostate cancer were categorized to age groups <75 years and ≥75 years. Changes in their quality of life were evaluated using the Japanese version of Medical Outcome Study 8-Items Short Form Health Survey, Expanded Prostate Cancer Index Composite and International Index of Erectile Function-5 at baseline, and followed up to 24 months after treatment. There were no significant differences in Medical Outcome Study 8-Items Short Form Health Survey scores, and urinary and bowel scores of the Expanded Prostate Cancer Index Composite for older men after treatment. International Index of Erectile Function-5 summary scores were significantly decreased in both groups. Although sexual function and sexual bother scores were decreased in patients aged <75 years, these scores were maintained in patients aged ≥75 years. Quality of life of prostate cancer patients undergoing high-dose rate brachytherapy combined with external beam radiation therapy does not seem to be significantly affected by age. © 2018 The Japanese Urological Association.

  1. Bunched beam diagnostics

    International Nuclear Information System (INIS)

    Siemann, R.H.

    1989-01-01

    There is a remarkable diversity in the field of accelerator physics. Look at the proceedings of any conference. Papers range from Hamiltonian dynamics to the latest improvements of performance in accelerator X to the engineering of specialized equipment. Beam diagnostics is somewhere in the middle of this. Diagnostic instruments make the connection between theories and observations, and the capabilities of these instruments influence strongly our ability to improve performance. The gave a series of lectures in 1987 on the general topic of Principles of Beam Observation. The emphasis was on frequency domain analysis of beam generated signals in storage rings, and that is the subject of this paper. The goal is to connect spectrum analyzer observations to what the beam is doing. In addition, understanding beam spectra is essential for understanding coherent effects and instabilities in storage rings, and this is discussed extensively. 23 figures, 4 tables

  2. Combined experimental and numerical investigation of energy harness utilizing vortex induced vibration over half cylinder using piezoelectric beams

    Science.gov (United States)

    Ahmed, Md. Tusher; Hossain, Md. Tanver; Rahman, Md. Ashiqur

    2017-06-01

    Energy harvesting technology has the ability to create self-powered electronic systems that do not rely on battery power for their operation. Wind energy can be converted into electricity via a piezoelectric transducer during the air flow over a cylinder. The vortex-induced vibration over the cylinder causes the piezoelectric beam to vibrate. Thus useful electric energy at the range 0.2-0.3V is found which can be useful for self-powering small electronic devices. In the present study, prototypes of micro-energy harvester with a shape of 65 mm × 37 mm × 0.4 mm are developed and tested for airflow over D-shaped bluff body for diameters of 15, 20 and 28mm in an experimental setup consisting of a long wind tunnel of 57cm × 57cm with variable speeds of the motor for different flow velocities and the experimental setup is connected at the downstream where flow velocity is the maximum. Experimental results show that the velocity and induced voltage follows a regular linear pattern. A maximum electrical potential of 140 mV for velocity of 1.1 ms-1 at a bluff body diameter of 15 mm is observed in the energy harvester that can be applied in many practical cases for self-powering electronic devices. The simulation of this energy harvesting phenomena is then simulated using COMSOLE multi-physics. Diameter of the bluff bodies as well as flow velocity and size of cantilever beam are varied and the experimental findings are found to be in good agreement with the simulated ones. The simulations along with the experimental data show the possibility of generating electricity from vortex induced vibration and can be applied in many practical cases for self-powering electronic devices.

  3. Second malignancies following conventional or combined 252Cf neutron brachytherapy with external beam radiotherapy for breast cancer

    Science.gov (United States)

    Valuckas, Konstantinas Povilas; Atkocius, Vydmantas; Kuzmickiene, Irena; Aleknavicius, Eduardas; Liukpetryte, Sarune; Ostapenko, Valerijus

    2013-01-01

    We retrospectively evaluated the risk of second malignancies among 832 patients with inner or central breast cancer treated with conventional external beam schedule (CRT group), or neutron brachytherapy using Californium-252 (252Cf) sources and hypofractionated external beam radiotherapy (HRTC group), between 1987 and 1996 at the Institute of Oncology, Vilnius University. Patients were observed until the occurrences of death or development of a second malignancy, or until 31 December 2009, whichever was earlier. Median follow-up time was 10.4 years (range, 1.2–24.1 years). Risk of second primary cancers was quantified using standardized incidence ratios (SIRs). Cox proportional hazards regression models were used to estimate hazard ratios (HRs). There was a significant increase in the risk of second primary cancers compared with the general population (SIR 1.3, 95% CI 1.1–1.5). The observed number of second primary cancers was also higher than expected for breast (SIR 1.8, 95% CI 1.3–2.4) and lung cancer (SIR 3.8, 95% CI 2.0–6.7). For second breast cancer, no raised relative risk was observed during the period ≥10 or more years after radiotherapy. Compared with the CRT group, HRTC patients had a not statistically significant higher risk of breast cancer. Increased relative risks were observed specifically for age at initial diagnosis of <50 years (HR 2.9, 95% CI 1.6–5.2) and for obesity (HR 2.8, 95% CI 1.1–7.2). PMID:23397075

  4. Hypoxic versus normoxic external-beam irradiation of cervical carcinoma combined with californium-252 neutron brachytherapy. Comparative treatment results of a 5-year randomized study.

    Science.gov (United States)

    Tacev, Taco; Vacek, Antonín; Ptácková, Blanka; Strnad, Vratislav

    2005-05-01

    The article focuses on the treatment and protective effects of hypoxyradiotherapy during external-beam irradiation of cervical carcinoma, including paraaortic lymph nodes, combining radiotherapy with californium-252 ((252)Cf) neutron brachytherapy. An analysis of treatment results, early and late side effects and complications is presented. From January 1989 to May 1997, 307 women with stage IIb and IIIb cervical carcinoma, treated with (252)Cf neutron brachytherapy, were randomly divided into two groups and treated with external-beam irradiation to the paraaortic lymph nodes as follows: 155 patients (59 with stage IIb, 96 with stage IIIb) were treated by external-beam irradiation administered as a 60-Gy dose applied under conditions of acute hypoxia; 77 patients (30 with stage IIb and 47 with stage IIIb) received extended-field irradiation up to L4 and 78 patients (29 with stage IIb and 49 with stage IIIb) up to T12. 152 patients (58 with stage IIb, 94 with stage IIIb) were treated by external-beam irradiation administered as a 40-Gy dose applied under normal oxygenation conditions. 73 patients (29 with stage IIb and 44 with stage IIIb) received extended-field irradiaton up to L4 and 79 patients (29 with stage IIb and 50 with stage IIIb) up to T12. The same 56 Gy-equivalent (eq) doses at point A and 19 Gy-eq doses at point B were applied intracavitarily in both groups. The total radiation doses at points A and B were 99 and 79 Gy-eq, respectively, for patients treated with external-beam irradiation to 60 Gy under conditions of acute hypoxia. For patients treated with external-beam irradiation to 40 Gy under normal oxygenation conditions, the doses at points A and B were 85 and 59 Gy-eq, respectively. The 5-year overall survival rate for all patients (stages IIb and IIIb) was 7.0% better for patients treated in acute hypoxia than for patients treated under normal oxygenation conditions (78.7% vs. 71.7% [p < 0.16]). The 5-year metastases-free survival rate was

  5. Combined photon-electron beams in the treatment of the supraclavicular lymph nodes in breast cancer: A novel technique that achieves adequate coverage while reducing lung dose

    Energy Technology Data Exchange (ETDEWEB)

    Salem, Ahmed, E-mail: ahmed.salem@doctors.org.uk [Department of Radiation Oncology, King Hussein Cancer Center, Amman (Jordan); Mohamad, Issa; Dayyat, Abdulmajeed [Department of Radiation Oncology, King Hussein Cancer Center, Amman (Jordan); Kanaa’n, Haitham [Section of Medical Physics, Department of Radiation Oncology, King Hussein Cancer Center, Amman (Jordan); Sarhan, Nasim [Department of Radiation Oncology, King Hussein Cancer Center, Amman (Jordan); Roujob, Ibrahim [Section of Medical Physics, Department of Radiation Oncology, King Hussein Cancer Center, Amman (Jordan); Salem, Abdel-Fattah [Department of Obstetrics and Gynecology, Hashemite University, Zarqa (Jordan); Afifi, Shatha [Section of Medical Physics, Department of Radiation Oncology, King Hussein Cancer Center, Amman (Jordan); Jaradat, Imad; Mubiden, Rasmi; Almousa, Abdelateif [Department of Radiation Oncology, King Hussein Cancer Center, Amman (Jordan)

    2015-10-01

    Radiation pneumonitis is a well-documented side effect of radiation therapy for breast cancer. The purpose of this study was to compare combined photon-electron, photon-only, and electron-only plans in the radiation treatment of the supraclavicular lymph nodes. In total, 13 patients requiring chest wall and supraclavicular nodal irradiation were planned retrospectively using combined photon-electron, photon-only, and electron-only supraclavicular beams. A dose of 50 Gy over 25 fractions was prescribed. Chest wall irradiation parameters were fixed for all plans. The goal of this planning effort was to cover 95% of the supraclavicular clinical target volume (CTV) with 95% of the prescribed dose and to minimize the volume receiving ≥ 105% of the dose. Comparative end points were supraclavicular CTV coverage (volume covered by the 95% isodose line), hotspot volume, maximum radiation dose, contralateral breast dose, mean total lung dose, total lung volume percentage receiving at least 20 Gy (V{sub 20} {sub Gy}), heart volume percentage receiving at least 25 Gy (V{sub 25} {sub Gy}). Electron and photon energies ranged from 8 to 18 MeV and 4 to 6 MV, respectively. The ratio of photon-to-electron fractions in combined beams ranged from 5:20 to 15:10. Supraclavicular nodal coverage was highest in photon-only (mean = 96.2 ± 3.5%) followed closely by combined photon-electron (mean = 94.2 ± 2.5%) and lowest in electron-only plans (mean = 81.7 ± 14.8%, p < 0.001). The volume of tissue receiving ≥ 105% of the prescription dose was higher in the electron-only (mean = 69.7 ± 56.1 cm{sup 3}) as opposed to combined photon-electron (mean = 50.8 ± 40.9 cm{sup 3}) and photon-only beams (mean = 32.2 ± 28.1 cm{sup 3}, p = 0.114). Heart V{sub 25} {sub Gy} was not statistically different among the plans (p = 0.999). Total lung V{sub 20} {sub Gy} was lowest in electron-only (mean = 10.9 ± 2.3%) followed by combined photon-electron (mean = 13.8 ± 2.3%) and highest in photon

  6. Observation of Frequency Locked Coherent Transition Radiation

    CERN Document Server

    Marsh, Roark A; Temkin, Richard J

    2005-01-01

    Measurements of frequency locked, coherent transition radiation (CTR) were performed at the 17 GHz high-gradient accelerator facility built by Haimson Research Corporation at MIT PSFC. CTR produced from a metallic foil placed in the beam path was extracted through a window, and measured with a variety of detectors, including: diode, Helium cooled Si Bolometer, and double heterodyne receiver system. The angular energy distribution measured by the diode and bolometer are in agreement and consistent with calculations for a 15 MeV 200 mA 110 ns beam of 1 ps bunches. Heterodyne receiver measurements were able to show frequency locking, namely inter-bunch coherence at integer multiples of the accelerator RF frequency of 17.14 GHz. At the locked frequencies the power levels are enhanced by the number of bunches in a single beam pulse. The CTR was measured as a comb of locked frequencies up to 240 GHz, with a bandwidth of 50 MHz.

  7. Cohering power of quantum operations

    Energy Technology Data Exchange (ETDEWEB)

    Bu, Kaifeng, E-mail: bkf@zju.edu.cn [School of Mathematical Sciences, Zhejiang University, Hangzhou 310027 (China); Kumar, Asutosh, E-mail: asukumar@hri.res.in [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhabha National Institute, Anushaktinagar, Mumbai 400094 (India); Zhang, Lin, E-mail: linyz@zju.edu.cn [Institute of Mathematics, Hangzhou Dianzi University, Hangzhou 310018 (China); Wu, Junde, E-mail: wjd@zju.edu.cn [School of Mathematical Sciences, Zhejiang University, Hangzhou 310027 (China)

    2017-05-18

    Highlights: • Quantum coherence. • Cohering power: production of quantum coherence by quantum operations. • Study of cohering power and generalized cohering power, and their comparison for differentmeasures of quantum coherence. • Operational interpretation of cohering power. • Bound on cohering power of a generic quantum operation. - Abstract: Quantum coherence and entanglement, which play a crucial role in quantum information processing tasks, are usually fragile under decoherence. Therefore, the production of quantum coherence by quantum operations is important to preserve quantum correlations including entanglement. In this paper, we study cohering power–the ability of quantum operations to produce coherence. First, we provide an operational interpretation of cohering power. Then, we decompose a generic quantum operation into three basic operations, namely, unitary, appending and dismissal operations, and show that the cohering power of any quantum operation is upper bounded by the corresponding unitary operation. Furthermore, we compare cohering power and generalized cohering power of quantum operations for different measures of coherence.

  8. External beam radiation therapy for recurrent sigmoid colorectal cancer. Retrospective analysis by group comparison between the radiation therapy alone and the radiation therapy combined with other therapies

    International Nuclear Information System (INIS)

    Churei, Hisahiko; Takeshita, Tsuyoshi; Hiraki, Yoshiyuki; Baba, Yasutaka; Hokotate, Hirohumi; Nakajo, Masayuki; Ohkubo, Kouichi; Miyaji, Noriaki

    1999-01-01

    The purpose of this study is to evaluate retrospectively clinical efficacy of curativeintent external beam radiation therapy for recurrent sigmoid colorectal cancer. As the radiation therapy of higher dose level combined with other therapies might improve pain control, tumor response, and prognosis, the total dose over 60 Gy was delivered except cases that were received surgery for the recurrent tumor. The study population consisted of 25 patients received the radiation therapy alone (RTA) and 24 patients received the radiation therapy combined with other one or two treatment modalities (RTC), which included surgery (tumor resection) in 15 cases, chemotherapy (low dose daily CDDP) in 13 cases, and hyperthermia in 6 cases. They received the radiation therapy from January, 1989 to June, 1996. Data on pain relief and tumor response were compared between the groups of RTA and RTC. The effect on pain relief was not different between the two groups. Tumor response appeared to be high in the patients combined with chemotherapy, but the difference was not statistically significant between the groups. There were no differences in the prognosis by the recurrent tumor size, the pain relief, and the tumor response. There was a statistically significant difference in the prognosis between the groups with and without extrapelvic distant metastases. A more effective treatment modality combined with the external radiation therapy is necessary to improve the clinical efficacy for the recurrent sigmoid colorectal cancer. (author)

  9. Partially coherent imaging and spatial coherence wavelets

    International Nuclear Information System (INIS)

    Castaneda, Roman

    2003-03-01

    A description of spatially partially coherent imaging based on the propagation of second order spatial coherence wavelets and marginal power spectra (Wigner distribution functions) is presented. In this dynamics, the spatial coherence wavelets will be affected by the system through its elementary transfer function. The consistency of the model with the both extreme cases of full coherent and incoherent imaging was proved. In the last case we obtained the classical concept of optical transfer function as a simple integral of the elementary transfer function. Furthermore, the elementary incoherent response function was introduced as the Fourier transform of the elementary transfer function. It describes the propagation of spatial coherence wavelets form each object point to each image point through a specific point on the pupil planes. The point spread function of the system was obtained by a simple integral of the elementary incoherent response function. (author)

  10. Combined elemental analysis of ancient glass beads by means of ion beam, portable XRF, and EPMA techniques.

    Science.gov (United States)

    Sokaras, D; Karydas, A G; Oikonomou, A; Zacharias, N; Beltsios, K; Kantarelou, V

    2009-12-01

    Ion beam analysis (IBA)- and X-ray fluorescence (XRF)-based techniques have been well adopted in cultural-heritage-related analytical studies covering a wide range of diagnostic role, i.e., from screening purposes up to full quantitative characterization. In this work, a systematic research was carried out towards the identification and evaluation of the advantages and the limitations of laboratory-based (IBA, electron probe microanalyzer) and portable (milli-XRF and micro-XRF) techniques. The study focused on the analysis of an Archaic glass bead collection recently excavated from the city of Thebes (mainland, Greece), in order to suggest an optimized and synergistic analytical methodology for similar studies and to assess the reliability of the quantification procedure of analyses conducted in particular by portable XRF spectrometers. All the employed analytical techniques and methodologies proved efficient to provide in a consistent way characterization of the glass bead composition, with analytical range and sensitivity depending on the particular technique. The obtained compositional data suggest a solid basis for the understanding of the main technological features related to the raw major and minor materials utilized for the manufacture of the Thebian ancient glass bead collection.

  11. Hypoxic versus normoxic external-beam irradiation of cervical carcinoma combined with californium-252 neutron brachytherapy. Comparative treatment results of a 5-year randomized study

    International Nuclear Information System (INIS)

    Tacev, T.; Ptackova, B.; Vacek, A.; Strnad, V.

    2005-01-01

    Purpose: the article focuses on the treatment and protective effects of hypoxyradiotherapy during external-beam irradiation of cervical carcinoma, including paraaortic lymph nodes, combining radiotherapy with californium-252 ( 252 Cf) neutron brachytherapy. An analysis of treatment results, early and late side effects and complications is presented. Results: the 5-year overall survival rate for all patients (stages IIb and IIIb) was 7.0% better for patients treated in acute hypoxia than for patients treated under normal oxygenation conditions (78.7% vs. 71.7% [p < 0.16]). The 5-year metastases-free survival rate was better by 11.7% for stage IIIb patients in the hypoxyradiotherapy group with extended field up to T12 as compared to patients with extended field up to L4 (97.4% vs. 85.7% [p < 0.05]). Comparison of metastases-free survival rate of stage IIIb patients after external-beam irradiation with extended field up to T12 in hypoxic condition versus normoxic condition showed a 12% better result for patients in hypoxic condition (97.4% vs. 85.4% [p < 0.04]). Occurrences of symptomatic radiation-induced reactions during or shortly after irradiation were more frequently observed in patients treated with a lower dose under normoxic conditions. During the period of 6-12 years after treatment there were no changes in the frequencies of occurrences of late effects and complications. Conclusion: the importance of the protective effects of hypoxyradiotherapy for dose escalation in external-beam irradiation of cervical carcinoma, including paraaortic lymph nodes, with regard to an improvement of the cure rates of metastases in paraaortic lymph nodes has been confirmed. (orig.)

  12. Relationship between the position of the mental foramen and the anterior loop of the inferior alveolar nerve as determined by cone beam computed tomography combined with mimics.

    Science.gov (United States)

    Chen, Zhuogeng; Chen, Donghui; Tang, Li; Wang, Fenfen

    2015-01-01

    The position of the mental foramen and the anterior loop length of the inferior alveolar nerve serve as important anatomical landmarks for surgical procedures in the anterior mandibular region. The purpose of this study was to determine the relationship between the anterior loop of the inferior alveolar nerve and the mental foramen by combining cone beam computed tomography and Mimics, a software used to construct 3-dimensional (3D) interactive models of anatomical structures. Cone beam computed tomography images from a total of 60 patients were obtained and studied using GALAXY viewer or were imported into Mimics. The anterior loop of the inferior alveolar nerve was reconstructed 3-dimensionally, and then relevant parameters were measured. The parameters were measured, and their values include mean (SD) anterior loop length, 1.16 (1.78) mm; anterior loop angle, 19.13 (26.89) degrees; inferior alveolar canal diameter, 3.01 (0.67) mm; height of the inferior alveolar canal, 10.32 (1.56) mm; 2-dimensional mental foramen diameter, 2.97 (0.61) mm; 3D mental foramen diameter, 2.95 (0.59) mm; 2-dimensional vertical height of the mental foramen, 14.67 (1.67) mm; and 3D vertical height of the mental foramen, 14.61 (1.69) mm. The mental foramen was located apically between the first and second premolars in 51.67% and below the second premolar in 40.83% of the cases. A relationship was observed between the location of the mental foramen and the presence of the anterior loop of the inferior alveolar nerve. We highlight the effectiveness of cone beam computed tomography and 3D reconstruction in the identification of important anatomical structures relevant for preoperative assessment for surgical procedures in the anterior region of the mandible.

  13. Application of the relativistic electron beams originating in the discharges of plasma focus type for the combined laser-REB plasma heating

    International Nuclear Information System (INIS)

    Gribkov, V.A.

    1976-01-01

    Experimental investigations of the recent years allow to treat the discharge of plasma-focus-type (DPF) as an inductive storage with the switching time of the order of tens nsec. It results from the interferometry and X-ray measurements. The moment of the current sheath rupture coincides with the beginning of hard X-ray pulse. A considerable part of the bank energy (concentrated in the magnetic field near focus) converts into the electron beam energy with the mean energy of electrons of the order of 100 keV after the disruption of the current. The interferometry is allowed to investigate the dynamics of REB in DPF. The beam appeared to be divided into several filaments, and disturbed by ''hose'' instability and self-focusing inside the residual plasma. The X-ray pinhole pictures showed high plasma luminosity in the regions of beam focus, a neutron yield of the set-up had its maximum at this moment. All these data with anomalous scattering of diagnostic laser light in this region, high level of plasma noise with the frequency of the order of Langmuir frequency (by the factor of 10 6 ) and broad neutron spectra show us that an effective turbulent interaction of REB with plasma takes place in DPF. An experiment of particular interest for us involves the realization of laser initiated breakdown in the insulator and a combined laser-REB plasma heating. Analytical calculations indicate that when the REB energy is of the order of 10 4 to 10 6 J and the laser pulse duration of 10 -9 to 10 -10 sec, the laser energy of the order of 10 3 J is required for the experiment

  14. COHERENT LIDAR SYSTEM BASED ON A SEMICONDUCTOR LASER AND AMPLIFIER

    DEFF Research Database (Denmark)

    2009-01-01

    The present invention relates to a compact, reliable and low-cost coherent LIDAR (Light Detection And Ranging) system for remote wind-speed determination, determination of particle concentration, and/or temperature based on an all semiconductor light source and related methods. The present...... invention provides a coherent LIDAR system comprising a semiconductor laser for emission of a measurement beam of electromagnetic radiation directed towards a measurement volume for illumination of particles in the measurement volume, a reference beam generator for generation of a reference beam, a detector...

  15. Development of Raman-shifted probe laser beam for plasma ...

    Indian Academy of Sciences (India)

    Abstract. Optical diagnostics of laser-produced plasma requires a coherent, polarized probe beam synchronized with the pump beam. The probe beam should have energy above the background emission of plasma. Though the second harmonic probe beam satisfies most of the requirements, the plasma emission is larger ...

  16. Augmented corticotomy combined with accelerated orthodontic forces in class III orthognathic patients: morphologic aspects of the mandibular anterior ridge with cone-beam computed tomography.

    Science.gov (United States)

    Coscia, Giuseppe; Coscia, Vincenzo; Peluso, Vincenzo; Addabbo, Francesco

    2013-10-01

    This study used cone-beam computed tomography to evaluate morphologic changes of the mandibular anterior ridge after using augmented corticotomy plus accelerated orthodontia to decompensate mandibular incisors in patients with surgical skeletal Class III. Fourteen patients (8 men, 6 women; mean age, 26.14 yr) with skeletal Class III were treated before orthognathic surgery with a technique that combined corticotomy, bone grafting, and accelerated orthodontic forces to decompensate the lower incisors. Three-dimensional cone-beam computed tomograms were taken before treatment (T0) and at the completion of presurgical orthodontic treatment (T1). Measurements of the amount of vertical alveolar bone changes and horizontal bone thickness at the midroot and root apex levels of the mandibular incisors were evaluated. All patients showed significant proclination of the mandibular incisors at T1. The mean alveolar bone thickness from T0 to T1 increased buccally at the midroot and apex levels, showing statistically significant horizontal bone augmentation at the labial side of the lower anterior mandibular teeth (P orthodontics, such as marginal bone loss and gingival recession. Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  17. Direct writing of gold nanostructures with an electron beam: On the way to pure nanostructures by combining optimized deposition with oxygen-plasma treatment

    Directory of Open Access Journals (Sweden)

    Domagoj Belić

    2017-11-01

    Full Text Available This work presents a highly effective approach for the chemical purification of directly written 2D and 3D gold nanostructures suitable for plasmonics, biomolecule immobilisation, and nanoelectronics. Gold nano- and microstructures can be fabricated by one-step direct-write lithography process using focused electron beam induced deposition (FEBID. Typically, as-deposited gold nanostructures suffer from a low Au content and unacceptably high carbon contamination. We show that the undesirable carbon contamination can be diminished using a two-step process – a combination of optimized deposition followed by appropriate postdeposition cleaning. Starting from the common metal-organic precursor Me2-Au-tfac, it is demonstrated that the Au content in pristine FEBID nanostructures can be increased from 30 atom % to as much as 72 atom %, depending on the sustained electron beam dose. As a second step, oxygen-plasma treatment is established to further enhance the Au content in the structures, while preserving their morphology to a high degree. This two-step process represents a simple, feasible and high-throughput method for direct writing of purer gold nanostructures that can enable their future use for demanding applications.

  18. Direct visualization of fiber information by coherence.

    Science.gov (United States)

    Hlawitschka, Mario; Garth, Christoph; Tricoche, Xavier; Kindlmann, Gordon; Scheuermann, Gerik; Joy, Kenneth I; Hamann, Bernd

    2010-03-01

    The structure of fiber tracts in DT-MRI data presents a challenging problem for visualization and analysis. We derive visualization of such traces from a local coherence measure and achieve much improved visual segmentation. We introduce a coherence measure defined for fiber tracts. This quantitative assessment is based on infinitesimal deviations of neighboring tracts and allows identification and segmentation of coherent fiber regions. We use a hardware-accelerated implementation to achieve interactive visualization on slices and provide several approaches to visualize coherence information. Furthermore, we enhance existing techniques by combining them with coherence. We demonstrate our method on both a canine heart, where the myocardial structure is visualized, and a human brain, where we achieve detailed visualization of major and minor fiber bundles in a quality similar to and exceeding fiber clustering approaches. Our approach allows detailed and fast visualization of important anatomical structures in DT-MRI data sets.

  19. COHERENCE PROPERTIES OF ELECTROMAGNETIC RADIATION,

    Science.gov (United States)

    ELECTROMAGNETIC RADIATION , COHERENT SCATTERING), (*COHERENT SCATTERING, ELECTROMAGNETIC RADIATION ), LIGHT, INTERFERENCE, INTENSITY, STATISTICAL FUNCTIONS, QUANTUM THEORY, BOSONS, INTERFEROMETERS, CHINA

  20. Collapse of Incoherent Light Beams in Inertial Bulk Kerr Media

    DEFF Research Database (Denmark)

    Bang, Ole; Edmundson, Darran; Królikowski, Wieslaw

    1999-01-01

    We use the coherent density function theory to show that partially coherent beams are unstable and may collapse in inertial bulk Kerr media. The threshold power for collapse, and its dependence on the degree of coherence, is found analytically and checked-numerically. The internal dynamics of the...

  1. Combined Fluoroscopy- and CT-Guided Transthoracic Needle Biopsy Using a C-Arm Cone-Beam CT System: Comparison with Fluoroscopy-Guided Biopsy

    Science.gov (United States)

    Cheung, Joo Yeon; Shim, Sung Shine; Lim, Soo Mee

    2011-01-01

    Objective The aim of this study was to evaluate the usefulness of combined fluoroscopy- and CT-guided transthoracic needle biopsy (FC-TNB) using a cone beam CT system in comparison to fluoroscopy-guided TNB (F-TNB). Materials and Methods We retrospectively evaluated 74 FC-TNB cases (group A) and 97 F-TNB cases (group B) to compare their respective diagnostic accuracies according to the size and depth of the lesion, as well as complications, procedure time, and radiation dose. Results The sensitivity for malignancy and diagnostic accuracy for small ( 0.05). Concerning lesions ≥ 30 mm in size and fluoroscopy- and CT-guided TNB allows the biopsy of small (< 30 mm) and deep lesions (≥ 50 mm) with high diagnostic accuracy and short procedure times, whereas F-TNB is still a useful method for large and superficial lesions with a low radiation dose. PMID:21228944

  2. New flexible origination technology based on electron-beam lithography and its integration into security devices in combination with covert features based on DNA authentication

    Science.gov (United States)

    Drinkwater, John K.; Ryzi, Zbynek; Outwater, Chris S.

    2002-04-01

    Embossed diffractive optically variable devices are becoming increasingly familiar security items on plastic cards, banknotes, security documents and on branded goods and media to protect against counterfeit, protect copyright and to evidence tamper. Equally as this devices become both more widely available there is a pressing requirement for security technology upgrades to keep ahead of technology advances available to potential counterfeiters. This paper describes a new generation electron beam DOVID origination technology particularly suitable for high security applications. Covert marking of security devices is provided using the DNA matrix by creating and verifying unique DNA sequences. This integration of this into practical security features in combination with covert features based on DNA matrix authentication and other more straightforwardly authenticable features to provide multi- technology security solutions will be described.

  3. Optimal beam forming for laser beam propagation through random media

    Science.gov (United States)

    Liu, Baoyong

    Focusing optical beams on a target through random propagation media is very important in many applications such as free space optical communications and laser weapons. Random media effects such as beam spread and scintillation can degrade the optical system's performance severely. Compensation schemes are needed in these applications to overcome these random media effects. In this research, we investigated the optimal beams for two different optimization criteria: one is to maximize the concentrated received intensity and the other is to minimize the scintillation index at the target plane. In the study of the optimal beam to maximize the weighted integrated intensity, we derive a similarity relationship between pupil-plane phase screen and extended Huygens-Fresnel model, and demonstrate the limited utility of maximizing the average integrated intensity. In the study of the optimal beam to minimize the scintillation index, we derive the first- and second-order moments for the integrated intensity of multiple coherent modes. Hermite-Gaussian and Laguerre-Gaussian modes are used as the coherent modes to synthesize an optimal partially coherent beam. The optimal beams demonstrate evident reduction of scintillation index, and prove to be insensitive to the aperture averaging effect.

  4. Polyethylene glycol hydrogel rectal spacer implantation in patients with prostate cancer undergoing combination high-dose-rate brachytherapy and external beam radiotherapy.

    Science.gov (United States)

    Yeh, Jekwon; Lehrich, Brandon; Tran, Carolyn; Mesa, Albert; Baghdassarian, Ruben; Yoshida, Jeffrey; Torrey, Robert; Gazzaniga, Michael; Weinberg, Alan; Chalfin, Stuart; Ravera, John; Tokita, Kenneth

    2016-01-01

    To present rectal toxicity rates in patients administered a polyethylene glycol (PEG) hydrogel rectal spacer in conjunction with combination high-dose-rate brachytherapy and external beam radiotherapy. Between February 2010 and April 2015, 326 prostate carcinoma patients underwent combination high-dose-rate brachytherapy of 16 Gy (average dose 15.5 Gy; standard deviation [SD] = 1.6 Gy) and external beam radiotherapy of 59.4 Gy (average dose 60.2 Gy; SD = 2.9 Gy). In conjunction with the radiation therapy regimen, each patient was injected with 10 mL of a PEG hydrogel in the anterior perirectal fat space. The injectable spacer (rectal spacer) creates a gap between the prostate and the rectum. The rectum is displaced from the radiation field, and rectal dose is substantially reduced. The goal is a reduction in rectal radiation toxicity. Clinical efficacy was determined by measuring acute and chronic rectal toxicity using the National Cancer Center Institute Common Terminology Criteria for Adverse Events v4.0 grading scheme. Median followup was 16 months. The mean anterior-posterior separation achieved was 1.6 cm (SD = 0.4 cm). Rates of acute Grade 1 and 2 rectal toxicity were 37.4% and 2.8%, respectively. There were no acute Grade 3/4 toxicities. Rates of late Grade 1, 2, and 3 rectal toxicity were 12.7%, 1.4%, and 0.7%, respectively. There were no late Grade 4 toxicities. PEG rectal spacer implantation is safe and well tolerated. Acute and chronic rectal toxicities are low despite aggressive dose escalation. Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  5. Pretreatment Endorectal Coil Magnetic Resonance Imaging Findings Predict Biochemical Tumor Control in Prostate Cancer Patients Treated With Combination Brachytherapy and External-Beam Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Riaz, Nadeem [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Afaq, Asim; Akin, Oguz [Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Pei Xin; Kollmeier, Marisa A.; Cox, Brett [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Hricak, Hedvig [Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Zelefsky, Michael J., E-mail: zelefskm@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

    2012-11-01

    Purpose: To investigate the utility of endorectal coil magenetic resonance imaging (eMRI) in predicting biochemical relapse in prostate cancer patients treated with combination brachytherapy and external-beam radiotherapy. Methods and Materials: Between 2000 and 2008, 279 men with intermediate- or high-risk prostate cancer underwent eMRI of their prostate before receiving brachytherapy and supplemental intensity-modulated radiotherapy. Endorectal coil MRI was performed before treatment and retrospectively reviewed by two radiologists experienced in genitourinary MRI. Image-based variables, including tumor diameter, location, number of sextants involved, and the presence of extracapsular extension (ECE), were incorporated with other established clinical variables to predict biochemical control outcomes. The median follow-up was 49 months (range, 1-13 years). Results: The 5-year biochemical relapse-free survival for the cohort was 92%. Clinical findings predicting recurrence on univariate analysis included Gleason score (hazard ratio [HR] 3.6, p = 0.001), PSA (HR 1.04, p = 0.005), and National Comprehensive Cancer Network risk group (HR 4.1, p = 0.002). Clinical T stage and the use of androgen deprivation therapy were not correlated with biochemical failure. Imaging findings on univariate analysis associated with relapse included ECE on MRI (HR 3.79, p = 0.003), tumor size (HR 2.58, p = 0.04), and T stage (HR 1.71, p = 0.004). On multivariate analysis incorporating both clinical and imaging findings, only ECE on MRI and Gleason score were independent predictors of recurrence. Conclusions: Pretreatment eMRI findings predict for biochemical recurrence in intermediate- and high-risk prostate cancer patients treated with combination brachytherapy and external-beam radiotherapy. Gleason score and the presence of ECE on MRI were the only significant predictors of biochemical relapse in this group of patients.

  6. Adaptive optics-assisted optical coherence tomography for imaging of patients with age related macular degeneration

    Science.gov (United States)

    Sudo, Kenta; Cense, Barry

    2013-03-01

    We developed an optical coherence tomography (OCT) prototype with a sample arm that uses a 3.4 mm beam, which is considerably larger than the 1.2 to 1.5 mm beam that is used in commercialized OCT systems. The system is equipped with adaptive optics (AO), and to distinguish it from traditional AO-OCT systems with a larger 6 mm beam we have coined this concept AO-assisted OCT. Compared to commercialized OCT systems, the 3.4 mm aperture combined with AO improves light collection efficiency and imaging lateral resolution. In this paper, the performance of the AOa-OCT system was compared to a standard OCT system and demonstrated for imaging of age-related macular degeneration (AMD). Measurements were performed on the retinas of three human volunteers with healthy eyes and on one eye of a patient diagnosed with AMD. The AO-assisted OCT system imaged retinal structures of healthy human eyes and a patient eye affected by AMD with higher lateral resolution and a 9° by 9° field of view. This combination of a large isoplanatic patch and high lateral resolution can be expected to fill a gap between standard OCT with a 1.2 mm beam and conventional AO-OCT with a 6 mm beam and a 1.5° by 1.5° isoplanatic patch.

  7. Combination of External Beam Radiotherapy (EBRT) With Intratumoral Injection of Dendritic Cells as Neo-Adjuvant Treatment of High-Risk Soft Tissue Sarcoma Patients

    Energy Technology Data Exchange (ETDEWEB)

    Finkelstein, Steven E., E-mail: steven.finkelstein@moffitt.org [H. Lee Moffitt Cancer Center, Tampa, FL (United States); Iclozan, Cristina; Bui, Marilyn M.; Cotter, Matthew J.; Ramakrishnan, Rupal; Ahmed, Jamil; Noyes, David R.; Cheong, David; Gonzalez, Ricardo J.; Heysek, Randy V.; Berman, Claudia; Lenox, Brianna C.; Janssen, William; Zager, Jonathan S.; Sondak, Vernon K.; Letson, G. Douglas; Antonia, Scott J. [H. Lee Moffitt Cancer Center, Tampa, FL (United States); Gabrilovich, Dmitry I., E-mail: dmitry.gabrilovich@moffitt.org [H. Lee Moffitt Cancer Center, Tampa, FL (United States)

    2012-02-01

    Purpose: The goal of this study was to determine the effect of combination of intratumoral administration of dendritic cells (DC) and fractionated external beam radiation (EBRT) on tumor-specific immune responses in patients with soft-tissue sarcoma (STS). Methods and Material: Seventeen patients with large (>5 cm) high-grade STS were enrolled in the study. They were treated in the neoadjuvant setting with 5,040 cGy of EBRT, split into 28 fractions and delivered 5 days per week, combined with intratumoral injection of 10{sup 7} DCs followed by complete resection. DCs were injected on the second, third, and fourth Friday of the treatment cycle. Clinical evaluation and immunological assessments were performed. Results: The treatment was well tolerated. No patient had tumor-specific immune responses before combined EBRT/DC therapy; 9 patients (52.9%) developed tumor-specific immune responses, which lasted from 11 to 42 weeks. Twelve of 17 patients (70.6%) were progression free after 1 year. Treatment caused a dramatic accumulation of T cells in the tumor. The presence of CD4{sup +} T cells in the tumor positively correlated with tumor-specific immune responses that developed following combined therapy. Accumulation of myeloid-derived suppressor cells but not regulatory T cells negatively correlated with the development of tumor-specific immune responses. Experiments with {sup 111}In labeled DCs demonstrated that these antigen presenting cells need at least 48 h to start migrating from tumor site. Conclusions: Combination of intratumoral DC administration with EBRT was safe and resulted in induction of antitumor immune responses. This suggests that this therapy is promising and needs further testing in clinical trials design to assess clinical efficacy.

  8. Lack of Apparent Survival Benefit With Use of Androgen Deprivation Therapy in Patients With High-risk Prostate Cancer Receiving Combined External Beam Radiation Therapy and Brachytherapy.

    Science.gov (United States)

    Yang, David D; Muralidhar, Vinayak; Mahal, Brandon A; Nguyen, Paul L; Devlin, Phillip M; King, Martin T; Orio, Peter F

    2018-01-01

    Although level 1 evidence has demonstrated a survival benefit from the addition of androgen deprivation therapy (ADT) to external beam radiation therapy (EBRT) for patients with high-risk prostate cancer, the benefits of ADT with combined EBRT and brachytherapy for high-risk patients are unclear. We examined the association between ADT and overall survival in a national cohort of high-risk patients treated with EBRT with or without brachytherapy. We identified 46,325 men in the National Cancer Database with a diagnosis of high-risk prostate cancer (Gleason score 8-10, clinical stage T3-T4, or prostate-specific antigen >20 ng/mL) who were treated with EBRT with or without brachytherapy and ADT from 2004 through 2011. Multivariable Cox regression analysis adjusting for sociodemographic and clinicopathologic factors was used to identify the association between ADT and overall survival. The median follow-up period was 48.6 and 59.2 months for patients treated with EBRT only and combined modality RT, respectively. ADT was associated with an improvement in overall survival for the 85.0% (39,361) of the study cohort who underwent EBRT alone (adjusted hazard ratio 0.91, P=.001) but not for patients treated with combined modality RT (adjusted hazard ratio 1.05, P=.496), with a significant interaction (P interaction =.036). In contrast to the known survival benefit when ADT is given with EBRT, our results suggest that ADT might not improve survival for high-risk patients who undergo combined EBRT and brachytherapy. Given the significant adverse effects of ADT, in particular, with long-term therapy, a randomized controlled trial of combined EBRT and brachytherapy with or without ADT for select high-risk patients using a noninferiority design should be undertaken. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. The Coherent X-ray Imaging (CXI) Instrument at the Linac Coherent Light Source (LCLS)

    International Nuclear Information System (INIS)

    Boutet, Sebastien

    2011-01-01

    The Linac Coherent Light Source (LCLS) has become the first ever operational hard X-ray Free Electron Laser in 2009. It will operate as a user facility capable of delivering unique research opportunities in multiple fields of science. The LCLS and the LCLS Ultrafast Science Instruments (LUSI) construction projects are developing instruments designed to make full use of the capabilities afforded by the LCLS beam. One such instrument is being designed to utilize the LCLS coherent beam to image with high resolution any sub-micron object. This instrument is called the Coherent X-ray Imaging (CXI) instrument. This instrument will provide a flexible optical system capable of tailoring key beam parameters for the users. A suite of shot-to-shot diagnostics will also be provided to characterize the beam on every pulse. The provided instrumentation will include multi-purpose sample environments, sample delivery and a custom detector capable of collecting 2D data at 120 Hz. In this article, the LCLS will be briefly introduced along with the technique of Coherent X-ray Diffractive Imaging (CXDI). A few examples of scientific opportunities using the CXI instrument will be described. Finally, the conceptual layout of the instrument will be presented along with a description of the key requirements for the overall system and specific devices required.

  10. The Coherent X-ray Imaging (CXI) Instrument at the Linac Coherent Light Source (LCLS)

    Energy Technology Data Exchange (ETDEWEB)

    Boutet, Sebastien; Williams, Garth J.; /SLAC

    2011-08-16

    The Linac Coherent Light Source (LCLS) has become the first ever operational hard X-ray Free Electron Laser in 2009. It will operate as a user facility capable of delivering unique research opportunities in multiple fields of science. The LCLS and the LCLS Ultrafast Science Instruments (LUSI) construction projects are developing instruments designed to make full use of the capabilities afforded by the LCLS beam. One such instrument is being designed to utilize the LCLS coherent beam to image with high resolution any sub-micron object. This instrument is called the Coherent X-ray Imaging (CXI) instrument. This instrument will provide a flexible optical system capable of tailoring key beam parameters for the users. A suite of shot-to-shot diagnostics will also be provided to characterize the beam on every pulse. The provided instrumentation will include multi-purpose sample environments, sample delivery and a custom detector capable of collecting 2D data at 120 Hz. In this article, the LCLS will be briefly introduced along with the technique of Coherent X-ray Diffractive Imaging (CXDI). A few examples of scientific opportunities using the CXI instrument will be described. Finally, the conceptual layout of the instrument will be presented along with a description of the key requirements for the overall system and specific devices required.

  11. Determination of beam coupling impedance in the frequency domain

    Energy Technology Data Exchange (ETDEWEB)

    Niedermayer, Uwe

    2016-07-01

    The concept of beam coupling impedance describes the electromagnetic interaction of uniformly moving charged particles with their surrounding structures in the Frequency Domain (FD). In synchrotron accelerators, beam coupling impedances can lead to beam induced component heating and coherent beam instabilities. Thus, in order to ensure the stable operation of a synchrotron, its impedances have to be quantified and their effects have to be controlled. Nowadays, beam coupling impedances are mostly obtained by Fourier transform of wake potentials, which are the results of Time Domain (TD) simulations. However, at low frequencies, low beam velocity, or for dispersive materials, TD simulations become unhandy. In this area, analytical calculations of beam coupling impedance in the FD, combined with geometry approximations, are still widely used. This thesis describes the development of two electromagnetic field solvers to obtain the beam coupling impedance directly in the FD, where the beam velocity is only a parameter and dispersive materials can be included easily. One solver is based on the Finite Integration Technique (FIT) on a staircase mesh. It is implemented both in 2D and 3D. However, the staircase mesh is inefficient on curved structures, which is particularly problematic for the modeling of a dipole source, that is required for the computation of the transverse beam coupling impedance. This issue is overcome by the second solver developed in this thesis, which is based on the Finite Element Method (FEM) on an unstructured triangular mesh. It is implemented in 2D and includes an optional Surface Impedance Boundary Condition (SIBC). Thus, it is well suited for the computation of longitudinal and transverse impedances of long beam pipe structures of arbitrary cross-section. Besides arbitrary frequency and beam velocity, also dispersive materials can be chosen, which is crucial for the computation of the impedance of ferrite kicker magnets. Numerical impedance

  12. Treatment Results of PDR Brachytherapy Combined With External Beam Radiotherapy in 106 Patients With Intermediate- to High-Risk Prostate Cancer

    International Nuclear Information System (INIS)

    Pieters, Bradley R.; Geijsen, Elisabeth D.; Koedooder, Kees; Blank, Leo E.C.M.; Rezaie, Elisa; Grient, Johan N.B. van der; Reijke, Theo M. de; Koning, Caro C.E.

    2011-01-01

    Purpose: To evaluate treatment outcome of pulsed dose-rate brachytherapy (PDR) combined with external-beam radiotherapy (EBRT) for the treatment of prostate cancer. Methods and Materials: Between 2002 and 2007, 106 patients were treated by EBRT combined with PDR and followed prospectively. Two, 38, and 66 patients were classified as low-, intermediate-, and high-risk disease respectively according to the National Comprehensive Cancer Network criteria. EBRT dose was 46 Gy in 2.0-Gy fractions. PDR dose was increased stepwise from 24.96 to 28.80 Gy. Biochemical disease free survival and overall survival were determined by the Kaplan-Meier method. Cumulative incidence of late gastrointestinal (GI) and genitourinary (GU) toxicity were scored, according to the Common Terminology Criteria for Adverse Events. Results: The 3- and 5-year biochemical nonevidence of disease (bNED) were 92.8% (95% confidence interval [CI], 87.1-98.5) and 89.5% (95% CI, 85.2-93.8), respectively. Overall survival at 3 and 5 years was 99% (95% CI, 96-100) and 96% (95% CI, 90-100), respectively. The 3- and 5-year Grade 2 GI toxicity was 5.3% (95% CI, 0-10.6) and 12.0% (95% CI, 1.4-22.6), respectively. No Grade 3 or higher GI toxicity was observed. The 3- and 5-year Grade 2 or higher GU toxicity was 18.7% (95% CI, 10.3-27.1) and 26.9% (95% CI, 15.1-38.7), respectively. Conclusion: Results on tumor control and late toxicity of EBRT combined with PDR are good and comparable to results obtained with EBRT combined with high-dose-rate brachytherapy for the treatment of prostate cancer.

  13. Performance of quantum cloning and deleting machines over coherence

    Science.gov (United States)

    Karmakar, Sumana; Sen, Ajoy; Sarkar, Debasis

    2017-10-01

    Coherence, being at the heart of interference phenomena, is found to be an useful resource in quantum information theory. Here we want to understand quantum coherence under the combination of two fundamentally dual processes, viz., cloning and deleting. We found the role of quantum cloning and deletion machines with the consumption and generation of quantum coherence. We establish cloning as a cohering process and deletion as a decohering process. Fidelity of the process will be shown to have connection with coherence generation and consumption of the processes.

  14. SU-F-T-430: Validation of IBEAM Evo Couch Top for Different Relative Electron Density (RED) Combination During Photon Beam Dose Calculation in Monaco− Treatment Planning System

    Energy Technology Data Exchange (ETDEWEB)

    Manigandan, D; Kumar, M; Mohandas, P; Puri, A; Bhalla, N [Fortis Cancer Institute, Mohali, Punjab (India)

    2016-06-15

    Purpose: Validation of iBEAM™ evo couch-top for different relative electron density (RED) combination during photon beam dose calculation in Monaco− TPS. Methods: The iBEAM™ evo couch-top has two layers:outer carbon fiber (CF) and inner foam core (FC). To study the beam intensity attenuation of couch-top, measured doses were compared with doses calculated for different REDs. Measurements were performed in solid water phantom with PTW-0.125cc ion-chamber positioned at center of the phantom with 5.3cm thickness slabs placed above and below the chamber. Similarly, in TPS, iBEAM™ evo couch-top was simulated and doses were calculated for different RED combinations (0.2CF-0.2FC, 0.4CF-0.2FC, 0.6CF-0.2FC, 0.8CF-0.2FC, and 1.0CF-0.2FC) by using Monte Carlo dose calculation algorithm in Monaco TPS (V5.1). Doses were measured for every 10 degree gantry angle separation, 10×10cm{sup 2} field size and 6MV photons. Then, attenuation is defined as the ratio of output at posterior gantry angle to output of its opposed anterior gantry angle (e.g.225°/45°). output fluctuation with different gantry angle was within ±0.21%. To confirm above results, dose-planes were measured for five pelvic VMAT plans (360°arc) in PTW two-dimensional array and compared with different calculated dose-planes of above-mentioned couch REDs. Gamma pass rates<1.00) were analyzed for 3%/2mm criteria. Results: Measured and calculated attenuation was in good agreement for the RED combination of 0.2CF-0.2FC and difference was within ±0.515%. However, other density combination showed difference of ±0.9841%, ±1.667%, ±2.9241% and ±2.8832% for 0.4CF-0.2FC, 0.6CF-0.2FC, 0.8CF-0.2FC, and 1.0CF-0.2FC, respectively. Maximum couch-top attenuation was observed at 110°–120° and 240°–250° and decreases linearly as the gantry angle approaches 180°. Moreover, gamma pass rate confirmed the above results and showed maximum pass rate of 96.23% for 0.2CF-0.2FC, whereas others were 95.72%, 95.12%, 94

  15. Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice

    International Nuclear Information System (INIS)

    Chang Mengya; Chen Yuhung; Chang Chihjui; Chen Helen H-W; Wu Chaoliang; Shiau Aili

    2008-01-01

    High atomic number material, such as gold, may be used in conjunction with radiation to provide dose enhancement in tumors. In the current study, we investigated the dose-enhancing effect and apoptotic potential of gold nanoparticles in combination with single-dose clinical electron beams on B16F10 melanoma tumor-bearing mice. We revealed that the accumulation of gold nanoparticles was detected inside B16F10 culture cells after 18 h of incubation, and moreover, the gold nanoparticles were shown to be colocalized with endoplasmic reticulum and Golgi apparatus in cells. Furthermore, gold nanoparticles radiosensitized melanoma cells in the colony formation assay (P=0.02). Using a B16F10 tumor-bearing mouse model, we further demonstrated that gold nanoparticles in conjunction with ionizing radiation significantly retarded tumor growth and prolonged survival compared to the radiation alone controls (P<0.05). Importantly, an increase of apoptotic signals was detected inside tumors in the combined treatment group (P<0.05). Knowing that radiation-induced apoptosis has been considered a determinant of tumor responses to radiation therapy, and the length of tumor regrowth delay correlated with the extent of apoptosis after single-dose radiotherapy, these results may suggest the clinical potential of gold nanoparticles in improving the outcome of melanoma radiotherapy. (author)

  16. Coherent interference effects in SIEM and CBED

    International Nuclear Information System (INIS)

    Cowley, J.M.

    1981-01-01

    The coherent convergent incident beam produced by the field emission gun of a STEM instrument allows the observation of a number of unusual interference effects in the shadow images (SIEM) and convergent beam diffraction (CBED) patterns visible on the detector plane. Shadow images of thin crystals display the electron Ronchigrams having a form sensitive to the defocus and aberrations of the objective lens. For large crystal lattice spacings the Ronchigrams show characteristic ellipses of low contrast. CBED patterns of thin crystal show symmetries and intensities which vary with the position of the incident beam within the unit cell. Discontinuities in the specimen such as the edges of crystals show striking Fresnel diffraction effects in SIEM. In CBED patterns they give rise to the splitting of diffraction spots. If the incident beam is parallel to a smooth face of a small crystal the potential field outside the crystal gives rise to strong refraction effects. (orig.)

  17. Ultrafast Coherent Absorption in Diamond Metamaterials.

    Science.gov (United States)

    Karvounis, Artemios; Nalla, Venkatram; MacDonald, Kevin F; Zheludev, Nikolay I

    2018-02-27

    Diamond is introduced as a material platform for visible/near-infrared photonic metamaterials, with a nanostructured polycrystalline diamond metasurface only 170 nm thick providing an experimental demonstration of coherent light-by-light modulation at few-optical-cycle (6 fs) pulse durations. "Coherent control" of absorption in planar (subwavelength-thickness) materials has emerged recently as a mechanism for high-contrast all-optical gating, with a speed of response that is limited only by the spectral width of the absorption line. It is shown here that a free-standing diamond membrane structured by focused ion beam milling can provide strong, spectrally near-flat absorption over a visible to near-infrared wavelength range that is wide enough (wider than is characteristically achievable in plasmonic metal metasurfaces) to facilitate coherent modulation of ultrashort optical pulses comprising only a few oscillations of electromagnetic field. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Fractionated perineal high-dose-rate temporary brachytherapy combined with external beam radiation in the treatment of localized prostate cancer: is lymph node sampling necessary?

    International Nuclear Information System (INIS)

    Gyorgy, Kovacs; Razvan, Galalae

    2003-01-01

    To study the influence of imaging based nodal staging and local dose escalation by a high-dose-rate brachytherapy (HDR-BT) boost in the treatment of locally confined prostate cancer in terms of prostate specific antigen (PSA) recurrence-free survival (biochemical non-evidence of disease (bNED)), treatment toxicity and prognostic variables. The prospectively recorded files of 144 men aged in a median of 68 years with a mean follow-up of 8 years (60-171 months) receiving curatively intended, transrectal ultrasound guided high-dose-rate 192-iridium-brachytherapy (HDR-BT) combined with external beam radiation therapy (EBRT) for locally confined prostate cancer were analyzed. T-stages were defined by digital rectal investigation and transrectal sonography (TRUS), nodal staging was performed with computed tomography (CT)/magnetic resonance imaging (MRI) (UICC/AJCR 1992). Twenty-nine patients (20.1%) had T1b-T2a tumors, and 115 patients had T2b-T3 tumors. Median initial PSA (iPSA) was 12.15 ng mL -1 (mean 25.61 ng mL -1 ). The total planned dose applied by external beam radiation was 50 Gy in the pelvis, and 40 Gy in the prostate by in-field-dose modification by individual compensators. The perineal, TRUS guided HDR-BT was delivered in two fractions of 15 Gy each. The target of BT boost was the peripheral zone of the prostate. The overall survival was 71.5%o and that of the disease free survival 82.6%. Freedom from distant metastases in T3 stage was 91.3%, whereas for G3 lesions, it was 88.23%. The bNED rate was 72.9%. Regarding treatment related late toxicity according to the EORTC/RTOG score, we observed grade 1, 2, 3 proctitis in 9.72%, 6.94%, 4.10% as well as grade 1, 2, 3 cystitis in 12.5%, 4.16%2.08%, respectively. Grade 4 and 5 proctitis or cystitis were not registered. The minimum 5-year and mean 8-year results confirm that local dose escalation by TRUS guided perineal HDR-BT and complementary external beam radiation of the pelvic lymphatics has curative potential

  19. High-dose-rate iridium-192 afterloading therapy combined with external beam radiotherapy for T1c-T3bN0M0 prostate cancer.

    Science.gov (United States)

    Jo, Yoshimasa; Hiratsuka, Junichi; Fujii, Tomohiro; Takenaka, Atsushi; Fujisawa, Masato

    2004-09-01

    To determine the efficacy of radiotherapy (RT) for T1c-T3bN0M0 prostate cancer in a prospective clinical trial of concurrent external beam RT and fractionated iridium-192 high-dose-rate brachytherapy. Included in the study were 98 patients with T1c-T3bN0M0 prostate cancer who were diagnosed between October 1997 and September 2002 and underwent high-dose-rate brachytherapy with external beam RT. Treatment consisted of external beam RT (four ports) to the prostate of 16 fractions of 2.3 Gy to a total dose of 36.8 Gy and high-dose-rate brachytherapy of 4 fractions of 6.0 Gy within 30 hours to a total dose of 24.0 Gy. No patient received adjuvant hormonal therapy after RT. The most recent prostate-specific antigen level was 0.0 to 3.9 ng/mL (median 0.4). Seven patients (7.1%) developed recurrence and treatment was considered a failure (bone metastasis in two and biochemical failure in five). The overall biochemical disease-free survival (bDFS) rate was 95.9% at 2 years and 92.9% at 5 years. The bDFS rate by T stage was 98.6% at 2 years and 95.9% at 5 years for Stage T1c-T2b and 88.0% and 84.0% for Stage T3a-b, respectively (P = 0.047). The 2-year and 5-year bDFS rate was better in patients with an initial prostate-specific antigen level of less than 20 ng/mL compared with 20 ng/mL or greater (98.6% and 97.1% versus 93.1% and 82.8%, respectively, P = 0.0261). Acute toxicity was mild to moderate (Radiation Therapy Oncology Group grade 1-2) and consisted of cystourethritis or proctitis in 29 (29.6%) of 98 patients. With a low complication rate and satisfactory bDFS rates, this combination therapy can be considered an alternative method for clinical Stage T1c-T3b prostate cancer and is expected to improve patient quality of life. Additional long-term follow-up is needed to confirm this treatment.

  20. Tunable, anomalous Mie scattering using spatial coherence.

    Science.gov (United States)

    Wang, Yangyundou; Schouten, Hugo F; Visser, Taco D

    2015-10-15

    We demonstrate that a J0-Bessel-correlated beam that is incident on a homogeneous sphere produces a highly unusual distribution of the scattered field, with the maximum no longer occurring in the forward direction. Such a beam can be easily generated using a spatially incoherent, annular source. Moreover, the direction of maximal scattering can be shifted by changing the spatial coherence length. In this process, the total power that is scattered remains constant. This new tool to control scattering directionality may be used to steer the scattered field away from the forward direction and selectively address detectors situated at different angles.

  1. Coherent error study in a retarding field energy analyzer

    International Nuclear Information System (INIS)

    Cui, Y.; Zou, Y.; Reiser, M.; Kishek, R.A.; Haber, I.; Bernal, S.; O'Shea, P.G.

    2005-01-01

    A novel cylindrical retarding electrostatic field energy analyzer for low-energy beams has been designed, simulated, and tested with electron beams of several keV, in which space charge effects play an important role. A cylindrical focusing electrode is used to overcome the beam expansion inside the device due to space-charge forces, beam emittance, etc. In this paper, we present the coherent error analysis for this energy analyzer with beam envelope equation including space charge and emittance effects. The study shows that this energy analyzer can achieve very high resolution (with relative error of around 10 -5 ) if taking away the coherent errors by using proper focusing voltages. The theoretical analysis is compared with experimental results

  2. Spin-polarized free electron beam interaction with radiation and superradiant spin-flip radiative emission

    Directory of Open Access Journals (Sweden)

    A. Gover

    2006-06-01

    Full Text Available The problems of spin-polarized free-electron beam interaction with electromagnetic wave at electron-spin resonance conditions in a magnetic field and of superradiant spin-flip radiative emission are analyzed in the framework of a comprehensive classical model. The spontaneous emission of spin-flip radiation from electron beams is very weak. We show that the detectivity of electron spin resonant spin-flip and combined spin-flip/cyclotron-resonance-emission radiation can be substantially enhanced by operating with ultrashort spin-polarized electron beam bunches under conditions of superradiant (coherent emission. The proposed radiative spin-state modulation and the spin-flip radiative emission schemes can be used for control and noninvasive diagnostics of polarized electron/positron beams. Such schemes are of relevance in important scattering experiments off nucleons in nuclear physics and off magnetic targets in condensed matter physics.

  3. Improved outcome of131I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma.

    Science.gov (United States)

    Corroyer-Dulmont, Aurélien; Falzone, Nadia; Kersemans, Veerle; Thompson, James; Allen, Danny P; Able, Sarah; Kartsonaki, Christiana; Malcolm, Javian; Kinchesh, Paul; Hill, Mark A; Vojnovic, Boris; Smart, Sean C; Gaze, Mark N; Vallis, Katherine A

    2017-09-01

    To assess the efficacy of different schedules for combining external beam radiotherapy (EBRT) with molecular radiotherapy (MRT) using 131 I-mIBG in the management of neuroblastoma. BALB/c nu/nu mice bearing SK-N-SH neuroblastoma xenografts were assigned to five treatment groups: 131 I-mIBG 24h after EBRT, EBRT 6days after 131 I-mIBG, EBRT alone, 131 I-mIBG alone and control (untreated). A total of 56 mice were assigned to 3 studies. Study 1: Vessel permeability was evaluated using dynamic contrast-enhanced (DCE)-MRI (n=3). Study 2: Tumour uptake of 131 I-mIBG in excised lesions was evaluated by γ-counting and autoradiography (n=28). Study 3: Tumour volume was assessed by longitudinal MR imaging and survival was analysed (n=25). Tumour dosimetry was performed using Monte Carlo simulations of absorbed fractions with the radiation transport code PENELOPE. Given alone, both 131 I-mIBG and EBRT resulted in a seven-day delay in tumour regrowth. Following EBRT, vessel permeability was evaluated by DCE-MRI and showed an increase at 24h post irradiation that correlated with an increase in 131 I-mIBG tumour uptake, absorbed dose and overall survival in the case of combined treatment. Similarly, EBRT administered seven days after MRT to coincide with tumour regrowth, significantly decreased the tumour volume and increased overall survival. This study demonstrates that combining EBRT and MRT has an enhanced therapeutic effect and emphasizes the importance of treatment scheduling according to pathophysiological criteria such as tumour vessel permeability and tumour growth kinetics. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  4. Coherent Raman spectroscopy

    CERN Document Server

    Eesley, G L

    1981-01-01

    Coherent Raman Spectroscopy provides a unified and general account of the fundamental aspects of nonlinear Raman spectroscopy, also known as coherent Raman spectroscopy. The theoretical basis from which coherent Raman spectroscopy developed is described, along with its applications, utility, and implementation as well as advantages and disadvantages. Experimental data which typifies each technique is presented. This book is comprised of four chapters and opens with an overview of nonlinear optics and coherent Raman spectroscopy, followed by a discussion on nonlinear transfer function of matter

  5. New high power coherent radiation sources

    Science.gov (United States)

    Sprangle, P.; Coffey, T.

    1984-01-01

    In recent years, there has been considerable renewed interest in the development of novel devices for the production of high power coherent electromagnetic radiation. This interest has been motivated largely by the realization that, with existing technology, certain processes utilizing relativistic electron beams can produce coherent electromagnetic radiation at power levels far in excess of those achieved by conventional electron devices. This paper will review the current status of this rapidly developing field, with emphasis on two generic devices. The major thrust in the recent development of electron beam driven radiation sources has been directed towards achieving shorter wavelengths, greater power and higher efficiencies. Shortly after the development of such successful sources as the magnetron, kylstron and various traveling wave devices, it became clear that, in their original form, they were limited in their ability to produce high levels of radiation efficiently at short wavelengths. To circumvent the inherent limitations of these conventional coherent radiation sources, many new concepts and mechanisms, as well as variations on conventional concepts, were proposed. This paper is concerned primarily with two devices which are, relatively speaking, newcomers to the list of coherent classical radiation sources. They are the free electron laser and the cyclotron resonance maser (CRM); one well known type of CRM is the gyrotron.

  6. Multipulse addressing of a Raman quantum memory: configurable beam splitting and efficient readout.

    Science.gov (United States)

    Reim, K F; Nunn, J; Jin, X-M; Michelberger, P S; Champion, T F M; England, D G; Lee, K C; Kolthammer, W S; Langford, N K; Walmsley, I A

    2012-06-29

    Quantum memories are vital to the scalability of photonic quantum information processing (PQIP), since the storage of photons enables repeat-until-success strategies. On the other hand, the key element of all PQIP architectures is the beam splitter, which allows us to coherently couple optical modes. Here, we show how to combine these crucial functionalities by addressing a Raman quantum memory with multiple control pulses. The result is a coherent optical storage device with an extremely large time bandwidth product, that functions as an array of dynamically configurable beam splitters, and that can be read out with arbitrarily high efficiency. Networks of such devices would allow fully scalable PQIP, with applications in quantum computation, long distance quantum communications and quantum metrology.

  7. Terahertz Coherent Synchrotron Radiation in the MIT-Bates South Hall Ring

    CERN Document Server

    Wang, Fuhua; Cheever, Dan; Farkhondeh, Manouchehr; Franklin, Wilbur; Graves, William; Ihloff, Ernie; Podobedov, Boris; Sannibale, Fernando; Tschalär, C; Wang, Defa; Wang, Dong; Zwart, Townsend; van der Laan, Jan

    2005-01-01

    We investigate the terahertz coherent synchrotron radiation (CSR) potential of the South Hall Ring (SHR) at MIT-Bates Linear Accelerator Center. The SHR is equipped with a unique single cavity, 2.856 GHz RF system. The high RF frequency is advantageous for producing short bunch length and for having higher bunch current threshold to generate stable CSR. Combining with other techniques such as external pulse stacking cavity, femtosecond laser slicing, the potential for generating ultra-stable, high power, broadband terahertz CSR is very attractive. Beam dynamics issues related to short bunch length operation, and may associated with the high frequency RF system, such as multi-bunch instability are concerned. They could affect bunch length, bunch intensity and beam stability. The SHR is ideal for experimental exploration of these problems. Results of initial test of low momentum compaction lattice and bunch length measurements are presented and compared to expectations.

  8. Propagation properties of partially coherent super-Lorentz–Gauss modes through a paraxial and real ABCD optical system

    International Nuclear Information System (INIS)

    Zhou, Guoquan

    2010-01-01

    Based on the generalized Huygens–Fresnel integral and the Hermite–Gaussian expansion of a Lorentzian distribution, analytical expressions for the mutual coherence functions and the spatial complex degrees of coherence of the partially coherent super-Lorentz–Gauss (SLG) modes SLG 01 and SLG 11 through a paraxial and real ABCD optical system are derived. As a numerical example, the focusing of the partially coherent SLG 01 and SLG 11 modes is illustrated, and the influence of the spatial correlation length on the normalized intensity distributions and the spatial complex degrees of coherence is examined. The analytical formulae of the beam propagation factors of the partially coherent SLG 01 and SLG 11 modes are also presented. The effects of the beam parameter and the coherent parameter on the beam propagation factors are numerically investigated

  9. Coherence, Cohesion, and Deixis.

    Science.gov (United States)

    Foster, Dan

    Composition theory accounts of coherence have tended to look at relationships within the text rather than at those between the text and the real world. In fact, empirical evidence suggests that the relationships between the text and the real world may be just as important for coherence. Forty-eight short papers were selected at random from those…

  10. Combined Yttrium-90 microsphere selective internal radiation therapy and external beam radiotherapy in patients with hepatocellular carcinoma: From clinical aspects to dosimetry.

    Directory of Open Access Journals (Sweden)

    Ti-Hao Wang

    Full Text Available Selective internal radiation therapy (SIRT is an effective treatment strategy for unresectable hepatocellular carcinoma (HCC patients. However, the prognoses of patients with portal vein thrombosis, extra-hepatic metastases, or residual tumors remain poor when treated with SIRT alone. In these patients, sequential external beam radiotherapy (EBRT may offer a chance of salvage. Here, we reported the clinical outcomes and the detailed dosimetry analysis of 22 patients treated with combination therapy.Between October 2011 and May 2015, 22 consecutive patients who underwent EBRT after yttrium-90 (90Y SIRT were included in this study. The post-SIRT 90Y bremsstrahlung SPECT/CT of each patient was transferred to dose distribution by adopting the local deposition hypothesis. The patient-specific 3-dimensional biological effective dose distribution of combined SIRT and EBRT was generated. The overall survival and safety were evaluated. The relationship between dosimetric parameters and liver toxicity was analyzed.The mean administered activity of SIRT was 1.50 GBq (range: 0.5-2.8. The mean prescribed dose of EBRT was 42.3 Gy (range: 15-63 in 14 fractions (range: 5-15 and was targeted to the residual liver tumor in 12 patients (55%, portal vein thrombosis in 11 patients (50%, and perihilar lymphadenopathies in 4 patients (18%. The overall 1-, 2-, and 3-year survival rates were 59.8%, 47.9%, and 47.9%, respectively. Overall, 8 patients (36% developed > grade 2 liver toxicities, and the Child-Pugh score prior to EBRT strongly affected the toxicity risk. A dosimetry analysis restricted to 18 Child-Pugh A/B patients showed that the V100 (The fraction of normal liver exposed to more than 100 Gy to V140 significance differed between patients who did or did not experience hepatotoxicity. The V110 was the strongest predictor of hepatotoxicity (18.6±11.6% vs 29.5±5.8%; P = 0.030.Combined therapy is feasible and safe if patients are carefully selected

  11. Combined Yttrium-90 microsphere selective internal radiation therapy and external beam radiotherapy in patients with hepatocellular carcinoma: From clinical aspects to dosimetry.

    Science.gov (United States)

    Wang, Ti-Hao; Huang, Pin-I; Hu, Yu-Wen; Lin, Ko-Han; Liu, Ching-Sheng; Lin, Yi-Yang; Liu, Chien-An; Tseng, Hsiou-Shan; Liu, Yu-Ming; Lee, Rheun-Chuan

    2018-01-01

    Selective internal radiation therapy (SIRT) is an effective treatment strategy for unresectable hepatocellular carcinoma (HCC) patients. However, the prognoses of patients with portal vein thrombosis, extra-hepatic metastases, or residual tumors remain poor when treated with SIRT alone. In these patients, sequential external beam radiotherapy (EBRT) may offer a chance of salvage. Here, we reported the clinical outcomes and the detailed dosimetry analysis of 22 patients treated with combination therapy. Between October 2011 and May 2015, 22 consecutive patients who underwent EBRT after yttrium-90 (90Y) SIRT were included in this study. The post-SIRT 90Y bremsstrahlung SPECT/CT of each patient was transferred to dose distribution by adopting the local deposition hypothesis. The patient-specific 3-dimensional biological effective dose distribution of combined SIRT and EBRT was generated. The overall survival and safety were evaluated. The relationship between dosimetric parameters and liver toxicity was analyzed. The mean administered activity of SIRT was 1.50 GBq (range: 0.5-2.8). The mean prescribed dose of EBRT was 42.3 Gy (range: 15-63) in 14 fractions (range: 5-15) and was targeted to the residual liver tumor in 12 patients (55%), portal vein thrombosis in 11 patients (50%), and perihilar lymphadenopathies in 4 patients (18%). The overall 1-, 2-, and 3-year survival rates were 59.8%, 47.9%, and 47.9%, respectively. Overall, 8 patients (36%) developed > grade 2 liver toxicities, and the Child-Pugh score prior to EBRT strongly affected the toxicity risk. A dosimetry analysis restricted to 18 Child-Pugh A/B patients showed that the V100 (The fraction of normal liver exposed to more than 100 Gy) to V140 significance differed between patients who did or did not experience hepatotoxicity. The V110 was the strongest predictor of hepatotoxicity (18.6±11.6% vs 29.5±5.8%; P = 0.030). Combined therapy is feasible and safe if patients are carefully selected. Specifically

  12. Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute.

    Science.gov (United States)

    Janulionis, Ernestas; Valuckas, Konstantinas Povilas; Liukpetryte, Sarune; Samerdokiene, Vitalija; Atkocius, Vydmantas

    2015-10-01

    The purpose of this paper was to observe and compare long-term curative effects and complications of FIGO stage IIB cervical cancer patients (n = 232) treated with high-dose-rate (HDR) californium ((252)Cf) neutron or cobalt ((60)Co) photon intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT). The EBRT dose to the small pelvis was 50 Gy in both groups. The brachytherapy component of (252)Cf or (60)Co was added in the 3(rd) week of EBRT, 5 fractions were performed once per week resulting in a total ICBT dose of 40 Gy/Gyeq (point A). Overall survival (OS) at 5, 10 and 15 years was 63.6%, 50.4% and 38.8% in the (252)Cf group and 62.2%, 50.5%, 39.9%, in the (60)Co group, respectively (p = 0.74). The percentage of tumour recurrence was statistically significantly lower in the (252)Cf group with 7.4% versus 17.1% in the (60)Co group (p = 0.02). Second primary cancers have developed similarly 9.1% and 8.1% cases for (252)Cf and (60)Co groups, respectively. Our long-term retrospective study comparing (252)Cf and (60)Co isotopes with brachytherapy in combined treatment of FIGO IIB stage cervix carcinoma patients shows, that overall survival in the both groups are similar. However, the recurrence of tumour was significantly lower in the (252)Cf group. The incidence of second primary cancers was similar in both groups.

  13. Combination of external beam radiotherapy and Californium (Cf)-252 neutron intracavity brachytherapy is more effective in control of cervical squamous cell carcinoma than that of cervical adenocarcinoma.

    Science.gov (United States)

    Xiong, Yanli; Liu, Jia; Chen, Shu; Zhou, Qian; Xu, Wenjing; Tang, Chen; Chen, Yonghong; Yang, Mei; Lei, Xin

    2015-09-01

    The objective of this study was to compare the effect of combined external beam radiotherapy (EBRT) and Californium (Cf)-252 neutron intracavity brachytherapy (ICBT) on cervical squamous versus adenocarcinoma. A total of 106 patients with stage IB-IIIB cervical cancer were accrued between January 2005 and May 2011 and divided into squamous cell carcinoma (SCC) and adenocarcinoma (AC) as a pair with 53 patients in each group according to tumor size, stage, age, and hemoglobin level using matched-pair design. The whole pelvic EBRT was performed with 2 Gy/fraction, 4 fractions/week. The total dose was 48-54 Gy (the center of whole pelvic field was blocked by 4 cm in width after 20-36 Gy). Cf-252 neutron ICBT was delivered with 11 and 12 Gy-eq/f with the total dose at point A of 44 and 48 Gy-eq for SCC and AC patients, respectively. The mean follow-up time was 43 months. The 5-year LC, OS, DFS, LAC rates, and mean survival time were 66.0, 56.6, 52.8.0, 17.0%, and 76.4 ± 6.2 months, respectively, for AC patients, whereas they were 81.1, 69.8, 67.9, 11.3%, and 93.3 ± 4.3 months, respectively, for SCC patients. Furthermore, the early treatment toxicity was mild in both groups, the late treatment complications were mainly radiation-induced proctitis and cystitis, and there were no grade 3 or higher complications. Although the combination of Cf-252 neutron ICBT and EBRT was effective in both histology types of cervical cancer, a more aggressive strategy is needed to control cervical AC.

  14. Scalable coherent interface

    International Nuclear Information System (INIS)

    Alnaes, K.; Kristiansen, E.H.; Gustavson, D.B.; James, D.V.

    1990-01-01

    The Scalable Coherent Interface (IEEE P1596) is establishing an interface standard for very high performance multiprocessors, supporting a cache-coherent-memory model scalable to systems with up to 64K nodes. This Scalable Coherent Interface (SCI) will supply a peak bandwidth per node of 1 GigaByte/second. The SCI standard should facilitate assembly of processor, memory, I/O and bus bridge cards from multiple vendors into massively parallel systems with throughput far above what is possible today. The SCI standard encompasses two levels of interface, a physical level and a logical level. The physical level specifies electrical, mechanical and thermal characteristics of connectors and cards that meet the standard. The logical level describes the address space, data transfer protocols, cache coherence mechanisms, synchronization primitives and error recovery. In this paper we address logical level issues such as packet formats, packet transmission, transaction handshake, flow control, and cache coherence. 11 refs., 10 figs

  15. Compact compressive arc and beam switchyard for energy recovery linac-driven ultraviolet free electron lasers

    Science.gov (United States)

    Akkermans, J. A. G.; Di Mitri, S.; Douglas, D.; Setija, I. D.

    2017-08-01

    High gain free electron lasers (FELs) driven by high repetition rate recirculating accelerators have received considerable attention in the scientific and industrial communities in recent years. Cost-performance optimization of such facilities encourages limiting machine size and complexity, and a compact machine can be realized by combining bending and bunch length compression during the last stage of recirculation, just before lasing. The impact of coherent synchrotron radiation (CSR) on electron beam quality during compression can, however, limit FEL output power. When methods to counteract CSR are implemented, appropriate beam diagnostics become critical to ensure that the target beam parameters are met before lasing, as well as to guarantee reliable, predictable performance and rapid machine setup and recovery. This article describes a beam line for bunch compression and recirculation, and beam switchyard accessing a diagnostic line for EUV lasing at 1 GeV beam energy. The footprint is modest, with 12 m compressive arc diameter and ˜20 m diagnostic line length. The design limits beam quality degradation due to CSR both in the compressor and in the switchyard. Advantages and drawbacks of two switchyard lines providing, respectively, off-line and on-line measurements are discussed. The entire design is scalable to different beam energies and charges.

  16. Collecting optical coherence elastography depth profiles with a micromachined cantilever probe

    NARCIS (Netherlands)

    Chavan, D.C.; Mo, J.; de Groot, M.; Meijering, A.E.C.; de Boer, J.F.; Iannuzzi, D.

    2013-01-01

    We present an experimental setup that combines optical coherence elastography depth sensing with atomic force microscope indentation. The instrument relies on a miniaturized cantilever probe that compresses a sample with a small footprint force and simultaneously collects an optical coherence

  17. Bunch Length Measurements using Coherent Radiation

    CERN Document Server

    Ischebeck, Rasmus; Barnes, Christopher; Blumenfeld, Ian; Clayton, Chris; Decker, Franz Josef; Deng, Suzhi; Hogan, Mark; Huang Cheng Kun; Iverson, Richard; Johnson, Devon K; Krejcik, Patrick; Lu, Wei; Marsh, Kenneth; Oz, Erdem; Siemann, Robert; Walz, Dieter

    2005-01-01

    The accelerating field that can be obtained in a beam-driven plasma wakefield accelerator depends on the current of the electron beam that excites the wake. In the E-167 experiment, a peak current above 10kA will be delivered at a particle energy of 28GeV. The bunch has a length of a few ten micrometers and several methods are used to measure its longitudinal profile. Among these, autocorrelation of coherent transition radiation (CTR) is employed. The beam passes a thin metallic foil, where it emits transition radiation. For wavelengths greater than the bunch length, this transition radiation is emitted coherently. This amplifies the long-wavelength part of the spectrum. A scanning Michelson interferometer is used to autocorrelate the CTR. However, this method requires the contribution of many bunches to build an autocorrelation trace. The measurement is influenced by the transmission characteristics of the vacuum window and beam splitter. We present here an analysis of materials, as well as possible layouts ...

  18. Multiple-Symbol, Partially Coherent Detection of MPSK

    Science.gov (United States)

    Simon, Marvin K.; Divsalar, Dariush

    1994-01-01

    Proposed method of reception of multiple-phase-shift-keyed (MPSK) radio signals involves multiple-symbol, partially coherent detection. Instead of attempting to determine phase of transmitted signal during each symbol period as in coherent detection, receiver acquires signal data during multiple-symbol observation interval, then produces maximum-likelihood-sequence estimate of phases transmitted during interval. Combination of coherent-reception and incoherent-reception decision rules are used.

  19. Frontiers of particle beams: Intensity limitations

    International Nuclear Information System (INIS)

    Dienes, M.; Month, M.; Turner, S.

    1992-01-01

    The present volume is the proceedings of the latest of these joint schools, held on Hilton Head Island, South Carolina, in 1990. This course dealt with intensity limitations and was centered on a series of lectures which could be divided into the following main categories: Self and environmental fields, Coherent instabilities and their simulation, Beam-beam interaction, Other multiparticle effects, Beam source limitations, Engineering limitations. (orig.)

  20. Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach.

    Science.gov (United States)

    Guo, Xiaoya; Giddens, Don P; Molony, David; Yang, Chun; Samady, Habib; Zheng, Jie; Mintz, Gary S; Maehara, Akiko; Wang, Liang; Pei, Xuan; Li, Zhi-Yong; Tang, Dalin

    2018-04-01

    Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular ultrasound (VH-IVUS) sets cap thickness to zero when cap is under resolution limit and IVUS does not see it. An innovative modeling approach combining IVUS and optical coherence tomography (OCT) is introduced for cap thickness quantification and more accurate cap stress/strain calculations. In vivo IVUS and OCT coronary plaque data were acquired with informed consent obtained. IVUS and OCT images were merged to form the IVUS + OCT data set, with biplane angiography providing three-dimensional (3D) vessel curvature. For components where VH-IVUS set zero cap thickness (i.e., no cap), a cap was added with minimum cap thickness set as 50 and 180 μm to generate IVUS50 and IVUS180 data sets for model construction, respectively. 3D fluid-structure interaction (FSI) models based on IVUS + OCT, IVUS50, and IVUS180 data sets were constructed to investigate cap thickness impact on stress/strain calculations. Compared to IVUS + OCT, IVUS50 underestimated mean cap thickness (27 slices) by 34.5%, overestimated mean cap stress by 45.8%, (96.4 versus 66.1 kPa). IVUS50 maximum cap stress was 59.2% higher than that from IVUS + OCT model (564.2 versus 354.5 kPa). Differences between IVUS and IVUS + OCT models for cap strain and flow shear stress (FSS) were modest (cap strain <12%; FSS <6%). IVUS + OCT data and models could provide more accurate cap thickness and stress/strain calculations which will serve as basis for further plaque investigations.

  1. Energy transparency and symmetries in the beam-beam interaction

    Directory of Open Access Journals (Sweden)

    S. Krishnagopal

    2000-02-01

    Full Text Available We have modified the beam-beam simulation code CBI to handle asymmetric beams and used it to look at energy transparency and symmetries in the beam-beam interaction. We find that even a small violation of energy transparency, or of the symmetry between the two beams, changes the character of the collective (coherent motion; in particular, period-n oscillations are no longer seen. We speculate that the one-time observation of these oscillations at LEP, and the more ubiquitous observation of the flip-flop instability in colliders around the world, may be a consequence of breaking the symmetry between the electron and positron beams. We also apply this code to the asymmetric collider PEP-II, and find that for the nominal parameters of PEP-II, in particular, the nominal tune-shift parameter of ξ_{0}=0.03, there are no collective beam-beam issues. Collective quadrupole motion sets in only at ξ_{0}=0.06 and above, consistent with earlier observations for symmetric beams.

  2. Coherent Polariton Laser

    Science.gov (United States)

    Kim, Seonghoon; Zhang, Bo; Wang, Zhaorong; Fischer, Julian; Brodbeck, Sebastian; Kamp, Martin; Schneider, Christian; Höfling, Sven; Deng, Hui

    2016-01-01

    The semiconductor polariton laser promises a new source of coherent light, which, compared to conventional semiconductor photon lasers, has input-energy threshold orders of magnitude lower. However, intensity stability, a defining feature of a coherent state, has remained poor. Intensity noise many times the shot noise of a coherent state has persisted, attributed to multiple mechanisms that are difficult to separate in conventional polariton systems. The large intensity noise, in turn, limits the phase coherence. Thus, the capability of the polariton laser as a source of coherence light is limited. Here, we demonstrate a polariton laser with shot-noise-limited intensity stability, as expected from a fully coherent state. This stability is achieved by using an optical cavity with high mode selectivity to enforce single-mode lasing, suppress condensate depletion, and establish gain saturation. Moreover, the absence of spurious intensity fluctuations enables the measurement of a transition from exponential to Gaussian decay of the phase coherence of the polariton laser. It suggests large self-interaction energies in the polariton condensate, exceeding the laser bandwidth. Such strong interactions are unique to matter-wave lasers and important for nonlinear polariton devices. The results will guide future development of polariton lasers and nonlinear polariton devices.

  3. Coherent Polariton Laser

    Directory of Open Access Journals (Sweden)

    Seonghoon Kim

    2016-03-01

    Full Text Available The semiconductor polariton laser promises a new source of coherent light, which, compared to conventional semiconductor photon lasers, has input-energy threshold orders of magnitude lower. However, intensity stability, a defining feature of a coherent state, has remained poor. Intensity noise many times the shot noise of a coherent state has persisted, attributed to multiple mechanisms that are difficult to separate in conventional polariton systems. The large intensity noise, in turn, limits the phase coherence. Thus, the capability of the polariton laser as a source of coherence light is limited. Here, we demonstrate a polariton laser with shot-noise-limited intensity stability, as expected from a fully coherent state. This stability is achieved by using an optical cavity with high mode selectivity to enforce single-mode lasing, suppress condensate depletion, and establish gain saturation. Moreover, the absence of spurious intensity fluctuations enables the measurement of a transition from exponential to Gaussian decay of the phase coherence of the polariton laser. It suggests large self-interaction energies in the polariton condensate, exceeding the laser bandwidth. Such strong interactions are unique to matter-wave lasers and important for nonlinear polariton devices. The results will guide future development of polariton lasers and nonlinear polariton devices.

  4. Estimations of Coherent Instabilities for JLEIC

    Energy Technology Data Exchange (ETDEWEB)

    Li, Rui [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2017-05-01

    JLEIC is the medium energy electron-ion collider currently under active design at Jefferson Lab*. The design goals of JLEIC are both high luminosity (1033-1034 cm-2ses-1) and high polarization (>70%) for the electron and light ion beams, for a wide range of electron and ion beam energies and for a wide spectrum of ion species. The unprecedented luminosity goal for this electron-ion collider sets strong requirements for the understanding and management of potential collective effects in JLEIC. In this paper, we present preliminary estimations of single and coupled bunch coherent instabilities for the electron and proton beams at collision energies for the JLEIC design. Further improvement of the estimations and mitigation methods are discussed.

  5. Wien filter: A wave-packet-shifting device for restoring longitudinal coherence in charged-matter-wave interferometers

    Science.gov (United States)

    Nicklaus, Marc; Hasselbach, Franz

    1993-07-01

    Longitudinal coherence in two-beam interferometers means that the two partial wave packets arrive in the plane of interference simultaneously. In charged-particle interferometers, this simultaneity can be lost due to a difference in the geometrical path lengths, a difference in the optical path length, or a difference in the group velocities for the two wave packets on parts of or all of the beam paths. Several of those influences can combine to yield a net relative spatial delay between the wave packets in the interference plane, thus causing a reduction of the interference fringe contrast. A Wien filter can be used in charged-matter-wave interferometry to compensate for this relative delay and thus to reestablish longitudinal coherence. A Wien filter consists of an electric and a magnetic field perpendicular both to each other and the beam path. In its matched state, i.e., when the electrostatic and the magnetic forces on the electrons exactly cancel each other, the Wien filter neither deflects the beams nor exerts any phase shift on the wave packets. However, wave packets traveling through the Wien filter on laterally separated paths propagate in regions of different electric potentials and in turn with different group velocities, which leads to a longitudinal shift of the wave packets relative to each other. Maximum longitudinal coherence (and thereby fringe contrast) can be restored by choosing the compensating delay caused by the Wien filter exactly opposite to the net relative delay caused by the influences mentioned. An experiment is presented that demonstrates this property of a Wien filter. The coherence-reviving action of a Wien filter is discussed in the context of the incoherent superposition in the registration plane of the plane waves corresponding to different wavelengths in the electron spectrum. It demonstrates that the quantum-mechanical coherence of the self-interacting plane-wave components of the wave packets describing the particle ensemble

  6. Multi-focus beam shaping of high power multimode lasers

    Science.gov (United States)

    Laskin, Alexander; Volpp, Joerg; Laskin, Vadim; Ostrun, Aleksei

    2017-08-01

    Beam shaping of powerful multimode fiber lasers, fiber-coupled solid-state and diode lasers is of great importance for improvements of industrial laser applications. Welding, cladding with millimetre scale working spots benefit from "inverseGauss" intensity profiles; performance of thick metal sheet cutting, deep penetration welding can be enhanced when distributing the laser energy along the optical axis as more efficient usage of laser energy, higher edge quality and reduction of the heat affected zone can be achieved. Building of beam shaping optics for multimode lasers encounters physical limitations due to the low beam spatial coherence of multimode fiber-coupled lasers resulting in big Beam Parameter Products (BPP) or M² values. The laser radiation emerging from a multimode fiber presents a mixture of wavefronts. The fiber end can be considered as a light source which optical properties are intermediate between a Lambertian source and a single mode laser beam. Imaging of the fiber end, using a collimator and a focusing objective, is a robust and widely used beam delivery approach. Beam shaping solutions are suggested in form of optics combining fiber end imaging and geometrical separation of focused spots either perpendicular to or along the optical axis. Thus, energy of high power lasers is distributed among multiple foci. In order to provide reliable operation with multi-kW lasers and avoid damages the optics are designed as refractive elements with smooth optical surfaces. The paper presents descriptions of multi-focus optics as well as examples of intensity profile measurements of beam caustics and application results.

  7. Method and system to measure temperature of gases using coherent anti-stokes doppler spectroscopy

    Science.gov (United States)

    Rhodes, Mark

    2013-12-17

    A method of measuring a temperature of a noble gas in a chamber includes providing the noble gas in the chamber. The noble gas is characterized by a pressure and a temperature. The method also includes directing a first laser beam into the chamber and directing a second laser beam into the chamber. The first laser beam is characterized by a first frequency and the second laser beam is characterized by a second frequency. The method further includes converting at least a portion of the first laser beam and the second laser beam into a coherent anti-Stokes beam, measuring a Doppler broadening of the coherent anti-Stokes beam, and computing the temperature using the Doppler broadening.

  8. Removal of SO2 and NO/sub x/ from flue gas by means of a spray dryer/electron beam combination: a feasibility study

    International Nuclear Information System (INIS)

    Helfritch, D.J.; Feldman, P.L.; Ray, A.B.; Morgan, J.R.; Hildreth, G.A.

    1982-04-01

    This study examines the feasibility of adding an electron beam between the spray dryer and the fabric filter of dry scrubber flue gas desulfurization (FGD) systems. The beam promises effective removal of nitrogen oxides (NO/sub x/) and sulfur dioxide (SO 2 ), even at higher coal-sulfur levels than usually economic for dry scrubbers. The beam excites gas molecules, promoting reactions that convert SO 2 and NO/sub x/ to acids that then react with calcium compounds and are removed by the filter. Concerns examined here are feasibility and waste disposal. The cost findings are promising for both manufacture and operation. The system uses commercially available components. The relatively low temperatures and high humidity downstream of the spray dryer favor economic beam operation. The beam removes SO 2 , so the dryer can be run for economy, not high removal. The beam's incidental heating effect reduces reheat cost. Safe landfilling of the nitrate-rich waste appears practical, with leachate carrying no more nitrate than natural rain and dustfall. We expect natural pozzolanic reactions between alumina-silica compounds in the fly ash and lime compounds from the spray dryer to form an impermeable concrete-like material within 10 days after landfilling. Dry scrubber with electron beam appears competitive with commercial FGD systems, and we recommend a pilot scale operation

  9. Diffusion tensor optical coherence tomography

    Science.gov (United States)

    Marks, Daniel L.; Blackmon, Richard L.; Oldenburg, Amy L.

    2018-01-01

    In situ measurements of diffusive particle transport provide insight into tissue architecture, drug delivery, and cellular function. Analogous to diffusion-tensor magnetic resonance imaging (DT-MRI), where the anisotropic diffusion of water molecules is mapped on the millimeter scale to elucidate the fibrous structure of tissue, here we propose diffusion-tensor optical coherence tomography (DT-OCT) for measuring directional diffusivity and flow of optically scattering particles within tissue. Because DT-OCT is sensitive to the sub-resolution motion of Brownian particles as they are constrained by tissue macromolecules, it has the potential to quantify nanoporous anisotropic tissue structure at micrometer resolution as relevant to extracellular matrices, neurons, and capillaries. Here we derive the principles of DT-OCT, relating the detected optical signal from a minimum of six probe beams with the six unique diffusion tensor and three flow vector components. The optimal geometry of the probe beams is determined given a finite numerical aperture, and a high-speed hardware implementation is proposed. Finally, Monte Carlo simulations are employed to assess the ability of the proposed DT-OCT system to quantify anisotropic diffusion of nanoparticles in a collagen matrix, an extracellular constituent that is known to become highly aligned during tumor development.

  10. The adsorption of NO on an oxygen pre-covered Pt(1 1 1) surface: in situ high-resolution XPS combined with molecular beam studies

    Science.gov (United States)

    Zhu, J. F.; Kinne, M.; Fuhrmann, T.; Tränkenschuh, B.; Denecke, R.; Steinrück, H.-P.

    2003-12-01

    Adsorption of NO on a Pt(1 1 1) surface pre-covered with a p(2 × 2) atomic oxygen layer has been studied in situ by high-resolution X-ray photoelectron spectroscopy and temperature-programmed XPS using third-generation synchrotron radiation at BESSY II, Berlin, combined with molecular beam techniques and ex situ by low energy electron diffraction and temperature-programmed desorption. O 1s XP spectra reveal that an ordered p(2 × 2)-O layer dramatically changes the adsorption behavior of NO as compared to the clean surface. The atomic oxygen occupies fcc hollow sites, and therefore blocks NO adsorption on these sites, which are energetically preferred on clean Pt(1 1 1). As a consequence, NO populates on-top sites at low coverage. At 110 K for higher coverages, NO can additionally adsorb on hcp hollow sites, thereby inducing a shift of the O 1s binding energy of atomic oxygen towards lower energies by about 0.25 eV. The bond strength of the hcp hollow NO species to the substrate is weakened by the presence of atomic oxygen. A sharp p(2 × 2) LEED pattern is observed for NO adsorption on the oxygen pre-covered surface, up to saturation coverage. The total saturation coverage of NO on Pt(1 1 1) pre-covered with varying amounts of oxygen (below 0.25 ML) decreases linearly with the coverage of oxygen. The initial sticking coefficient of NO is reduced from 0.96 on clean Pt(1 1 1) to 0.88 on a p(2 × 2) oxygen pre-covered surface.

  11. Construction of coherent antistokes Raman spectroscopy (CARS)

    International Nuclear Information System (INIS)

    Zidan, M. D.; Jazmati, A.

    2007-01-01

    Coherent Antistokes Raman Spectroscopy (CARS) has been built. It consists of a Raman cell, which is filled with CO 2 gas at 5 atm pressure and a frequency doubled Nd-YAG laser pumped dye laser. The two beams are focused by means of a bi-convex lens into Raman cell. The Antistokes signals (CARS signals) are generated due to Four-wave mixing process. The antistokes signals were directed to monochrometer entrance slit by prism . The signals are detected by photomultiplier detector which is fixed on the exit slit and connected to data acquisition card located inside the computed case. The dye laser frequency has to be tuned to satisfy the energy difference between the ν 1 beam (Nd- YAG laser beam) and the ν 2 beam (the stokes beam or the dye laser beam) exactly corresponds to a vibrational - rotational Raman resonance (ν 2 - ν 1 = ν M ) in the 12 CO 2 or 13 CO 2 molecule, then the antistokes signals (ν 3 ) will be generated. The spectra of the CARS signals have been recorded to determine the isotope shift of 12 CO 2 , 13 CO 2 , which is 18.3 cm -1 . (author)

  12. Generation of Coherent Synchrotron Radiation from JAERI-ERL

    CERN Document Server

    Hajima, R; Kikuzawa, N; Minehara, E J; Nagai, R; Nishitani, T; Sawamura, M

    2005-01-01

    An electron beam with high-average current and short bunch length can be accelerated by energy-recovery linac. Coherent synchrotron radiation (CSR) from such an electron beam will be a useful light source around millimeter wavelength. We report results from a preliminary measurement of CSR emitted from a bending magnet of JAERI-ERL. Possible enhancement of CSR power by FEL micro-bunching is also discussed.

  13. Macroscopic coherent magnetic islands

    International Nuclear Information System (INIS)

    Porcelli, F.; Airoldi, A.; Angioni, C.

    2001-01-01

    We present experimental and theoretical investigations on the dynamics of coherent magnetic islands in high temperature, magnetically confined plasmas of thermonuclear interest, and of their effects on plasma transport. (author)

  14. Coherence in Industrial Transformation

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik; Lauridsen, Erik Hagelskjær

    2003-01-01

    The notion of coherence is used to illustrate the general finding, that the impact of environmental management systems and environmental policy is highly dependent of the context and interrelatedness of the systems, procedures and regimes established in society....

  15. Intracoronary optical coherence tomography

    DEFF Research Database (Denmark)

    Tenekecioglu, Erhan; Albuquerque, Felipe N; Sotomi, Yohei

    2017-01-01

    By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT)...

  16. Late rectal bleeding and genitourinary morbidity after high dose rate brachytherapy combined with hypofractionated external beam radiotherapy for localized prostate cancer

    International Nuclear Information System (INIS)

    Ebara, Takeshi; Akimoto, Tetsuo; Kato, Hiroyuki

    2007-01-01

    The purpose of this study was to evaluate late rectal bleeding and genitourinary (GU) morbidity in patients consecutively treated with combined high-dose-rate (HDR) brachytherapy and external beam radiation therapy (EBRT). Data from 80 patients treated consecutively from October 2000 to May 2004 were analyzed. The median age was 69 years old, median follow-up 31 months, ranging from 17-59 months. All patients received endocrine therapy before radiation therapy. The patients were divided into low-, intermediate- and high-risk groups (4/24/52 patients) according to the risk factors defined by T-classification, prostatic specific antigen (PSA) and Gleason score. Fractionation schedules for HDR brachytherapy were prospectively changed, and EBRT was fixed with 3 Gy fractions to 51 Gy. The distribution of fractionation was scheduled as follows; 5 Gy x 5 times in 14 patients, 7 Gy x 3 times in 19 patients, and 9 Gy x 2 times in 47 patients. The rectal bleeding was graded using the toxicity criteria of the Radiation Therapy Oncology Group and European Organization for Research and Treatment of Cancer while the genitourinary morbidities were graded using the toxicity criteria of the Common Terminology Criteria for Adverse Events v.3.0. Grade 2 or worse rectal bleeding developed in 9 patients (11.3%) with the 2-year actuarial probability at 11.2%. Grade 2 and 3 rectal bleeding was recognized in 8 and 1 patients, respectively. Grade 3 morbidity developed in the biopsied sites that were performed in the other hospital. No significant difference was observed in any HDR brachytherapy fractionation schedule. Grade 2 or worse GU morbidities were recognized in 30 patients (37.5%), consisting of 29 Grade 2 patients and 1 Grade 3 patient. Twenty-one patients in Grade 2 morbidity had an increase in the frequency of urination or nocturia, and urethral strictures developed in 3 patients. The 3-year actuarial probability of urethral stricture was 6.0%. One patient experienced Grade 3

  17. Long-term results for Stage IIIB cervical cancer patients receiving external beam radiotherapy combined with either HDR (252)Cf or HDR (60)Co intracavitary brachytherapy.

    Science.gov (United States)

    Ulinskas, K; Janulionis, E; Valuckas, K P; Samerdokiene, V; Atkocius, V; Rivard, M J

    2016-01-01

    The aim of this work was to compare the long-term curative effects and complications of patients diagnosed with cervical cancer International Federation of Gynecology and Obstetrics IIIB (n = 430) as treated with Californium-252 ((252)Cf) or cobalt-60 ((60)Co) intracavitary brachytherapy (ICBT) combined with external beam radiotherapy (EBRT). Cervical cancer cases with a history of treatment with (252)Cf or (60)Co ICBT combined with EBRT were selected from the Lithuanian National Cancer Institute database. Complications and second primary malignancies were compared in both patients groups. Estimates of the 5-, 10-, and 15-year overall survival and disease-free survival rates were computed with the Kaplan-Meier method and a Cox proportional hazards model applied using STATA software. At 5, 10, and 15 years, the overall survival rates were 46.9%, 39.3%, and 34.6% for the (252)Cf group and 35.4%, 26.9%, and 22.5% for the (60)Co group (p = 0.004), respectively. The disease-free survival rates were 42.1%, 35.0%, and 31.0% for the (252)Cf group and 32.0%, 25.1%, and 21.4% for the (60)Co group (p = 0.009), respectively. Histopathologic type of adenocarcinoma increased the risk of death for the (252)Cf group (hazard ratio 3.62). Histopathologic tumor type (hazard ratio 7.48) and recurrence (hazard ratio 2.83) were factors that statistically and significantly influenced the patient prognosis for the (60)Co group. Applying (252)Cf ICBT with EBRT was effective for International Federation of Gynecology and Obstetrics IIIB cervical cancer patients. Moreover, long-term followup data demonstrated higher survival rates in patients treated with (252)Cf ICBT than (60)Co ICBT. Complications in patients treated with neutron ICBT were not more frequent or severe than those treated with (60)Co ICBT. Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  18. Symmetry breaking by quantum coherence in single electron attachment

    Science.gov (United States)

    Krishnakumar, E.; Prabhudesai, Vaibhav S.; Mason, Nigel J.

    2018-02-01

    Quantum coherence-induced effects in atomic and molecular systems are the basis of several proposals for laser-based control of chemical reactions. So far, these rely on coherent photon beams inducing coherent reaction pathways that may interfere with one another, to achieve the desired outcome. This concept has been successfully exploited for removing the inversion symmetry in the dissociation of homonuclear diatomic molecules, but it remains to be seen if such quantum coherent effects can also be generated by the interaction of incoherent electrons with such molecules. Here we show that resonant electron attachment to H2 and the subsequent dissociation into H (n = 2) + H- is asymmetric about the inter-nuclear axis, whereas the asymmetry in D2 is far less pronounced. We explain this observation as due to attachment of a single electron resulting in a coherent superposition of two resonances of opposite parity. In addition to exemplifying a new quantum coherent process, our observation of coherent quantum dynamics involves the active participation of all three electrons and two nuclei, which could provide new tools for studying electron correlations as a means to control chemical processes, and demonstrates the role of coherent effects in electron-induced chemistry.

  19. Coherence and chaos

    International Nuclear Information System (INIS)

    Sudarshan, E.C.G.

    1993-01-01

    The annihilation operator for harmonic oscillator is a weighted shift operator and can be realized on a family of over complete coherent states. Shift operators arise in dynamical maps of systems exhibiting deterministic chaos. Generalized coherent states, called harmonious states, realize these maps in a simple manner. By analytic continuation the spectral family can be altered, thus furnishing an alternative perspective on resonant scattering. Singular distributions are necessary to reproduce the rich structure of chaotic and scattering systems

  20. Coherent imaging at FLASH

    International Nuclear Information System (INIS)

    Chapman, H N; Bajt, S; Duesterer, S; Treusch, R; Barty, A; Benner, W H; Bogan, M J; Frank, M; Hau-Riege, S P; Woods, B W; Boutet, S; Cavalleri, A; Hajdu, J; Iwan, B; Seibert, M M; Timneanu, N; Marchesini, S; Sakdinawat, A; Sokolowski-Tinten, K

    2009-01-01

    We have carried out high-resolution single-pulse coherent diffractive imaging at the FLASH free-electron laser. The intense focused FEL pulse gives a high-resolution low-noise coherent diffraction pattern of an object before that object turns into a plasma and explodes. In particular we are developing imaging of biological specimens beyond conventional radiation damage resolution limits, developing imaging of ultrafast processes, and testing methods to characterize and perform single-particle imaging.

  1. Combination of the H1 and ZEUS inclusive cross-section measurements at proton beam energies of 460 GeV and 575 GeV and tests of low Bjorken-x phenomenological models

    Energy Technology Data Exchange (ETDEWEB)

    Belov, Pavel

    2013-06-15

    A combination is presented of the inclusive neutral current e{sup {+-}}p scattering cross section data collected by the H1 and ZEUS collaborations during the last months of the HERA II operation period with proton beam energies E{sub p} of 460 and 575 GeV. The kinematic range of the cross section data covers low absolute four-momentum transfers squared, 1.5 GeV{sup 2} {<=} Q{sup 2} {<=} 110 GeV{sup 2}, small values of Bjorken-x, 2.8.10{sup -5} {<=} x {<=} 1.5.10{sup -2}, and high inelasticity y {<=} 0.85. The combination algorithm is based on the method of least squares and takes into account correlations of the systematic uncertainties. The combined data are used in the QCD fits to extract the parton distribution functions. The phenomenological low-x dipole models are tested and parameters of the models are obtained. A good description of the data by the dipole model taking into account the evolution of the gluon distribution is observed. The longitudinal structure function F{sub L} is extracted from the combination of the currently used H1 and ZEUS reduced proton beam energy data with previously published H1 nominal proton beam energy data of 920 GeV. A precision of the obtained values of F{sub L} is improved at medium Q{sup 2} compared to the published results of the H1 collaboration.

  2. Excitonic Coherence in Semiconductor Nanostructures Measured by Speckle Analysis

    DEFF Research Database (Denmark)

    Langbein, Wolfgang; Hvam, Jørn Märcher

    1999-01-01

    A new method to measure the time-dependent coherence of optical excitations in solids is presented, in which the coherence degree of light emission is deduced from its intensity fluctuations over the emission directions (speckles). With this method the decays of intensity and coherence...... are determined separately, thus distinguishing lifetime from pure dephasing. In particular, the secondary emission of excitons in semiconductor quantum wells is investigated. Here, the combination of static disorder and inelastic scattering leads to a partially coherent emission. The temperature dependence...

  3. High-brightness electron beam diagnostics at the ATF

    International Nuclear Information System (INIS)

    Wang, X.J.; Ben-Zvi, I.

    1996-01-01

    The Brookhaven Accelerator Test Facility (ATF) is a dedicated user facility for accelerator physicists. Its design is optimized to explore laser acceleration and coherent radiation production. To characterize the low-emittance, picoseconds long electron beam produced by the ATF's photocathode RF gun, we have installed electron beam profile monitors for transverse emittance measurement, and developed a new technique to measure electron beam pulse length by chirping the electron beam energy. We have also developed a new technique to measure the ps slice emittance of a 10 ps long electron beam. Stripline beam position monitors were installed along the beam to monitor the electron beam position and intensity. A stripline beam position monitor was also used to monitor the timing jitter between the RF system and laser pulses. Transition radiation was used to measure electron beam energy, beam profile and electron beam bunch length

  4. Superresolution beams

    CSIR Research Space (South Africa)

    Ngcobo, S

    2011-11-01

    Full Text Available zones capable of introducing a phase shift of zero or p on the alternately out of phase rings of the TEMp0 beams into a unified phase and then focusing the rectified beam to generate a high resolution beam which has a Gaussian beam intensity distribution...

  5. ICFA Beam Dynamics Newsletter

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Zvi I.; Kuczewski A.; Altinbas, Z.; Beavis, D.; Belomestnykh,; Dai, J. et al

    2012-07-01

    The Collider-Accelerator Department at Brookhaven National Laboratory is building a high-brightness 500 mA capable Energy Recovery Linac (ERL) as one of its main R&D thrusts towards eRHIC, the polarized electron - hadron collider as an upgrade of the operating RHIC facility. The ERL is in final assembly stages, with injection commisioning starting in October 2012. The objective of this ERL is to serve as a platform for R&D into high current ERL, in particular issues of halo generation and control, Higher-Order Mode (HOM) issues, coherent emissions for the beam and high-brightness, high-power beam generation and preservation. The R&D ERL features a superconducting laser-photocathode RF gun with a high quantum efficiency photoccathode served with a load-lock cathode delivery system, a highly damped 5-cell accelerating cavity, a highly flexible single-pass loop and a comprehensive system of beam instrumentation. In this ICFA Beam Dynamics Newsletter article we will describe the ERL in a degree of detail that is not usually found in regular publications. We will discuss the various systems of the ERL, following the electrons from the photocathode to the beam dump, cover the control system, machine protection etc and summarize with the status of the ERL systems.

  6. Transverse steering of two-component beams

    International Nuclear Information System (INIS)

    Murin, B.P.; Bondarev, B.U.; Durkin, A.P.; Lomize, L.G.; Soloviev, L.Yu.; Fedotov, A.P.

    Coherent transverse oscillations are considered which occur during simultaneous acceleration of proton and H - beams due to arbitrary displacements in elements of the focusing channel. To suppress these oscillations, a beam adjustment station is proposed, in which each quadrupole lens of two doublets is provided with a special dipole component of the magnetic field. These steering elements, together with the beam transverse position monitors, permit steering the transverse position of beams of opposite signs in both transverse planes. The number of steering stations needed is chosen, and some algorithms for control are discussed. It is shown that some of the control algorithms will permit not only the suppression of coherent oscillations, but a decrease in the radius and emittance of the beam

  7. Stimulated coherent transition radiation

    International Nuclear Information System (INIS)

    Hung-chi Lihn.

    1996-03-01

    Coherent radiation emitted from a relativistic electron bunch consists of wavelengths longer than or comparable to the bunch length. The intensity of this radiation out-numbers that of its incoherent counterpart, which extends to wavelengths shorter than the bunch length, by a factor equal to the number of electrons in the bunch. In typical accelerators, this factor is about 8 to 11 orders of magnitude. The spectrum of the coherent radiation is determined by the Fourier transform of the electron bunch distribution and, therefore, contains information of the bunch distribution. Coherent transition radiation emitted from subpicosecond electron bunches at the Stanford SUNSHINE facility is observed in the far-infrared regime through a room-temperature pyroelectric bolometer and characterized through the electron bunch-length study. To measure the bunch length, a new frequency-resolved subpicosecond bunch-length measuring system is developed. This system uses a far-infrared Michelson interferometer to measure the spectrum of coherent transition radiation through optical autocorrelation with resolution far better than existing time-resolved methods. Hence, the radiation spectrum and the bunch length are deduced from the autocorrelation measurement. To study the stimulation of coherent transition radiation, a special cavity named BRAICER is invented. Far-infrared light pulses of coherent transition radiation emitted from electron bunches are delayed and circulated in the cavity to coincide with subsequent incoming electron bunches. This coincidence of light pulses with electron bunches enables the light to do work on electrons, and thus stimulates more radiated energy. The possibilities of extending the bunch-length measuring system to measure the three-dimensional bunch distribution and making the BRAICER cavity a broadband, high-intensity, coherent, far-infrared light source are also discussed

  8. Multiple Scattering Model for Optical Coherence Tomography with Rytov Approximation

    KAUST Repository

    Li, Muxingzi

    2017-04-24

    Optical Coherence Tomography (OCT) is a coherence-gated, micrometer-resolution imaging technique that focuses a broadband near-infrared laser beam to penetrate into optical scattering media, e.g. biological tissues. The OCT resolution is split into two parts, with the axial resolution defined by half the coherence length, and the depth-dependent lateral resolution determined by the beam geometry, which is well described by a Gaussian beam model. The depth dependence of lateral resolution directly results in the defocusing effect outside the confocal region and restricts current OCT probes to small numerical aperture (NA) at the expense of lateral resolution near the focus. Another limitation on OCT development is the presence of a mixture of speckles due to multiple scatterers within the coherence length, and other random noise. Motivated by the above two challenges, a multiple scattering model based on Rytov approximation and Gaussian beam optics is proposed for the OCT setup. Some previous papers have adopted the first Born approximation with the assumption of small perturbation of the incident field in inhomogeneous media. The Rytov method of the same order with smooth phase perturbation assumption benefits from a wider spatial range of validity. A deconvolution method for solving the inverse problem associated with the first Rytov approximation is developed, significantly reducing the defocusing effect through depth and therefore extending the feasible range of NA.

  9. A compact FEL upconverter of coherent radiation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Y.; Marshall, T.C. [Columbia Univ., New York, NY (United States)

    1995-12-31

    The objective is to generate a powerful millimeter-wave FEL signal in a single pass, using a coherent microwave source (24GHz) to prebunch the electron beam for a harmonically-related wave (72GHz). We use the Columbia FEL facility, operating the electron beam at 600kV, 100A; undulator period = 1.85cm and 250G (K = 0.25); electron beam diameter = 3mm inside a 8.5 mm ID drift tube; guiding field of 8800G. Under these conditions, both the microwave signal (5kW input) and the millimeter signal will show travelling-wave gain in the TE11 mode. We report initial experimental results for the millimeter wave spectrum and find an overall power gain of {approximately}20 for the 24GHz input wave. Also presented will be numerical solutions of the wave growth using the FEL equations with slippage. This device has the advantage of producing a high-power FEL output in a single-pass travelling-wave configuration, obtaining a millimeter wave which is phase-referenced to a coherent laboratory source.

  10. Overlap junctions for high coherence superconducting qubits

    Science.gov (United States)

    Wu, X.; Long, J. L.; Ku, H. S.; Lake, R. E.; Bal, M.; Pappas, D. P.

    2017-07-01

    Fabrication of sub-micron Josephson junctions is demonstrated using standard processing techniques for high-coherence, superconducting qubits. These junctions are made in two separate lithography steps with normal-angle evaporation. Most significantly, this work demonstrates that it is possible to achieve high coherence with junctions formed on aluminum surfaces cleaned in situ by Ar plasma before junction oxidation. This method eliminates the angle-dependent shadow masks typically used for small junctions. Therefore, this is conducive to the implementation of typical methods for improving margins and yield using conventional CMOS processing. The current method uses electron-beam lithography and an additive process to define the top and bottom electrodes. Extension of this work to optical lithography and subtractive processes is discussed.

  11. Recent Progress on the Marylie/Impact Beam Dynamics Code

    International Nuclear Information System (INIS)

    Ryne, R.D.; Qiang, J.; Bethel, E.W.; Pogorelov, I.; Shalf, J.; Siegerist, C.; Venturini, M.; Dragt, A.J.; Adelmann, A.; Abell, D.; Amundson, J.; Spentzouris, P.; Neri, F.; Walstrom, P.; Mottershead, C.T.; Samulyak, R.

    2006-01-01

    MARYLIE/IMPACT (ML/I) is a hybrid code that combines the beam optics capabilities of MARYLIE with the parallel Particle-In-Cell capabilities of IMPACT. In addition to combining the capabilities of these codes, ML/I has a number of powerful features, including a choice of Poisson solvers, a fifth-order rf cavity model, multiple reference particles for rf cavities, a library of soft-edge magnet models, representation of magnet systems in terms of coil stacks with possibly overlapping fields, and wakefield effects. The code allows for map production, map analysis, particle tracking, and 3D envelope tracking, all within a single, coherent user environment. ML/I has a front end that can read both MARYLIE input and MAD lattice descriptions. The code can model beams with or without acceleration, and with or without space charge. Developed under a US DOE Scientific Discovery through Advanced Computing (SciDAC) project, ML/I is well suited to large-scale modeling, simulations having been performed with up to 100M macroparticles. The code inherits the powerful fitting and optimizing capabilities of MARYLIE augmented for the new features of ML/I. The combination of soft-edge magnet models, high-order capability, space charge effects, and fitting/optimization capabilities, make ML/I a powerful code for a wide range of beam optics design problems. This paper provides a description of the code and its unique capabilities

  12. Stable beams

    CERN Multimedia

    2015-01-01

    Stable beams: two simple words that carry so much meaning at CERN. When LHC page one switched from "squeeze" to "stable beams" at 10.40 a.m. on Wednesday, 3 June, it triggered scenes of jubilation in control rooms around the CERN sites, as the LHC experiments started to record physics data for the first time in 27 months. This is what CERN is here for, and it’s great to be back in business after such a long period of preparation for the next stage in the LHC adventure.   I’ve said it before, but I’ll say it again. This was a great achievement, and testimony to the hard and dedicated work of so many people in the global CERN community. I could start to list the teams that have contributed, but that would be a mistake. Instead, I’d simply like to say that an achievement as impressive as running the LHC – a machine of superlatives in every respect – takes the combined effort and enthusiasm of everyone ...

  13. Prognostic Significance of 5-Year PSA Value for Predicting Prostate Cancer Recurrence After Brachytherapy Alone and Combined With Hormonal Therapy and/or External Beam Radiotherapy

    International Nuclear Information System (INIS)

    Stock, Richard G.; Klein, Thomas J.; Cesaretti, Jamie A.; Stone, Nelson N.

    2009-01-01

    Purpose: To analyze the prognosis and outcomes of patients who remain free of biochemical failure during the first 5 years after treatment. Methods and Materials: Between 1991 and 2002, 742 patients with prostate cancer were treated with brachytherapy alone (n = 306), brachytherapy and hormonal therapy (n = 212), or combined implantation and external beam radiotherapy (with or without hormonal therapy; n = 224). These patients were free of biochemical failure (American Society for Therapeutic Radiology and Oncology [ASTRO] definition) during the first 5 post-treatment years and had a documented 5-year prostate-specific antigen (PSA) value. The median follow-up was 6.93 years. Results: The actuarial 10-year freedom from PSA failure rate was 97% using the ASTRO definition and 95% using the Phoenix definition. The median 5-year PSA level was 0.03 ng/mL (range, 0-3.6). The 5-year PSA value was ≤0.01 in 47.7%, >0.01-0.10 in 31.1%, >0.10-0.2 in 10.2%, >0.2-0.5 in 7.82%, and >0.5 in 3.10%. The 5-year PSA value had prognostic significance, with a PSA value of ≤0.2 ng/mL (n = 661) corresponding to a 10-year freedom from PSA failure rate of 99% with the ASTRO definition and 98% with the Phoenix definition vs. 86% (ASTRO definition) and 81% (Phoenix definition) for a PSA value ≥0.2 ng/mL (n = 81; p < .0001). The treatment regimen had no effect on biochemical failure. None of the 742 patients in this study developed metastatic disease or died of prostate cancer. Conclusion: The results of this study have shown that the prognosis for patients treated with brachytherapy and who remain biochemically free of disease for ≥5 years is excellent and none developed metastatic disease during the first 10 years after treatment. The 5-year PSA value is prognostic, and patients with a PSA value <0.2 ng/mL are unlikely to develop subsequent biochemical relapse.

  14. Pulsed dose rate brachytherapy as the boost in combination with external beam irradiation in base of tongue cancer. Long-term results from a uniform clinical series

    Directory of Open Access Journals (Sweden)

    Bengt Johansson

    2011-03-01

    Full Text Available Purpose: To evaluate long time outcome with regard to local tumour control, side effects and quality of life of