WorldWideScience

Sample records for clinico radiologica patologica

  1. Clinico- Pathological Study Of Ichthyosis Vulgaris

    Directory of Open Access Journals (Sweden)

    Nandy Utpal

    1997-01-01

    Full Text Available A clinico- pathological study of 28 cases of ichthyosis vulgaris appeared with in the age of 5 years. The presence of the disease since birth was also found. While most (24 patients showed a diminution of severity in summer with an aggravation during winter, 4 patients followed the opposite seasonal pattern. Only in 4 patients, fine scales in the scalp were detected. One patient showed an affection of flexures. There was also a low occurrence of palmo- planter hyperkeratosis, follicular keratosis, fissuring of hands and feet and atopy.

  2. [Clinico-roentgenological semiotics of the chest damage in polytrauma].

    Science.gov (United States)

    Zamiatin, P N; Panchenko, E V; Grigor'ian, G O; Goloshchapova, E V

    2006-10-01

    There are presented the main clinico-roentgenological signs of the chest damage in the injured persons, suffering polytrauma, according to the data from the specialized department of traumatic shock and polytrauma.

  3. Dermopathy of Graves′ disease: Clinico-pathological correlation

    Directory of Open Access Journals (Sweden)

    Sagili Vijaya Bhaskar Reddy

    2012-01-01

    Full Text Available Dermopathy of Graves′ disease is a classical, but uncommon extrathyroidal manifestation of Graves′ disease. The images of a typical case of dermopathy of Graves′ disease are presented along with clinico-pathological correlation.

  4. Clinico-lymphographic diagnosis of post-traumatic edema

    International Nuclear Information System (INIS)

    Chepelenko, G.V.

    1989-01-01

    Clinico-lymphographic comparisons in various manifestations of posttraumatic edema are presented. Early and delayed stages of chronic lymph flow violations are singled out. Data on distal non-progressing edema above foot edema following bone fractures in the low third of shank, in case of chronic edema of various limb segments occuring on the back-ground of muscle tissue atrophy are given. A clinico-lymphographic classification of posttraumatic edema is developed. Some new information on the value of lymphography in assessment of lymphographic lumen in bone defects, its substitution and elongation is reported

  5. Hepatocellular carcinoma: a clinico pathological study

    International Nuclear Information System (INIS)

    Abbasi, A.; Butt, N.; Bhutto, A.R.; Gulzar, K.; Munir, S.M.

    2010-01-01

    To describe the clinico-pathological and radiological profile of hepatocellular carcinoma. All consecutive patients suspected of having hepatocellular carcinoma (HCC), were admitted and included in this study. Diagnosis of HCC was established by clinical, biochemical, ultrasonographic and histopathologic findings. Patients with primary carcinoma elsewhere in the body, metastatic in the liver, fibrolamellar carcinoma and benign tumours were excluded from the study. At ultrasonography, the details of tumour size and number, portal vein thrombosis and presence of ascites were recorded. Patients were staged according to Okuda staging system. Results were described in mean and percentage values. There were 82 patients with hepatocellular carcinoma including 58 males and 24 females, with male to female ratio of 2.8:1. The mean age of patients was 56.24 +- 13.65 years. Right hypochondrial pain was the main symptom in 52 (63.4%) patients. The duration of symptoms varied from 1 month to 2 years. Tumour size was larger than 50% of liver size in 42 (51.2%) with portal vein thrombosis in 10 (12.19%). Anti HCV was positive in 44 (53.7%), HBsAg in 26 (31.7%) and both were found positive in 2 (2.44%) patients. Ten patients (12.2/%) found negative both for anti-HCV and HBsAg. According to Okuda staging system 18 patients had stage 1, 50 had stage 2 and 14 had stage 3 hepatocellular carcinoma. The mean age of presentation of hepatocellular carcinoma was younger as compared to western countries with potentially large non-resectable lesions. Chronic hepatitis C and B was found to be the major known factors. Patients with chronic hepatitis C and B should undergo vigorous HCC surveillance to detect early, potentially respectable HCC. (author)

  6. CLINICO-PATHOLOGICAL STUDY OF CERVICAL LYMPHADENOPATHY

    Directory of Open Access Journals (Sweden)

    Dova Subba

    2016-03-01

    Full Text Available OBJECTIVES To know the incidence and aetiological factors of cervical lymphadenopathy. To know the most common group of lymph nodes enlarged. To assess the response to management. MATERIALS AND METHODS This study includes 50 patients who attended the Surgical OPD, studied taking detailed clinical history, after physical examination and arriving at clinical diagnosis, confirmation was done by FNAC and biopsy. RESULTS Tuberculous lymphadenopathy is the commonest cause of cervical lymphadenopathy with 68% followed by chronic nonspecific lymphadenopathy with 32%. There was no case of sarcoidosis in this series. Disease commonly affected the 2 nd and 3 rd decades with 19% and 18% respectively. There is comparatively an increased incidence of tuberculous cervical lymphadenopathy in females than males. The average age of presentation was 30.5 years. There was no definite history of contact with tuberculosis in 82% of cases. In this study series, 44% of the patients belonged to the low income group, 46% belonged to the middle income group. There was only unilateral involvement of node in 72% of cases right side was affected in 32% and left side was affected in 40% of cases. Bilateral involvement was seen in 14% of the cases. The lymph nodes were associated with other groups of lymph nodes in 10% of cases. Chest radiography findings showed the evidence of coexisting active tuberculosis lesions in 8 out of 50 cases (16% and normal was 42(84%. CONCLUSION Knowledge about clinico-demographic perspectives of cervical lymphadenopathy in respect to their cytopathological diagnosis will help to detect/refer the respective cases early for investigations and treatment. Surgical intervention is definitely required in many cases, though most of the cases are medically curable.

  7. Clinico-Electroencephalography Pattern and Determinant of 2-year ...

    African Journals Online (AJOL)

    Clinico-Electroencephalography Pattern and Determinant of 2-year Seizure Control in Patients with Complex Partial Seizure Disorder in Kano, Northwestern ... Ability to predict seizure control on first diagnosis can be very useful in the management of patients with CPS. ... Data were analyzed using STATA version 10.

  8. Clinico-epidemiologic features of oculocutaneous albinism in ...

    African Journals Online (AJOL)

    Background: Oculocutaneous albinism (OCA) is a genetically heterogeneous group of disorders characterized by the absence or reduced pigmentation of the skin, hair and eyes. To assess the clinico-epidemiologic features of different forms of OCA among Egyptian patients, we performed a retrospective study to determine ...

  9. Clinico-histopathologic types of maxillofacial malignancies with ...

    African Journals Online (AJOL)

    Clinico-histopathologic types of maxillofacial malignancies with emphasis on sarcomas: A 10-year review. ... Sarcomas peaked in the third decade with 70% occurring below the age of 40 years. The maxilla and the mandible were the most afflicted sites in the maxillofacial region accounting for 52%. The patients on average

  10. Implementation of the procedure of high radiation of the forum about radiological protection in the health care environment; Implantacion del procedimiento de alta radiologica del foro sobre proteccion radiologica en el medio sanitario

    Energy Technology Data Exchange (ETDEWEB)

    Castro Novais, J.; Pardo Perez, E.; Molina Lopez, M. Y.; Ruiz Maqueda, S.; Maldonado Suarez, A.

    2013-07-01

    The objective of this work is to present the results of the implementation in our hospital the procedure of high radiological in patients treated with 131 I described in the document presented by the Forum on Radiation Protection in the Health Environment formed by the Consejo de Seguridad Nuclear and the Spanish societies of Fisica Medica and Proteccion Radiologica. (Author)

  11. Intraocular osseous metaplasia. A clinico-pathological study

    OpenAIRE

    Vemuganti Geeta; Honavar Santosh; Jalali Subhadra

    2002-01-01

    Purpose: To evaluate the clinico-pathologic features of intraocular osseous metaplasia. Methods: Pathology specimens of enucleated eyes submitted to the ophthalmic pathology service at a tertiary eye-care referral center between January 1995 and June 1999 were studied for intraocular osseous metaplasia. Specific histopathologic features noted in specimens with osseous metaplasia were the presence of retinal detachment, gliosis, retinal pigment epithelial hyperplasia, drusen, epiretinal membra...

  12. Varied clinico-radiological presentations of transmigrated canines

    Directory of Open Access Journals (Sweden)

    Ishita Gupta

    2015-01-01

    Full Text Available Canine is one of the most commonly impacted teeth in the dental arch. An unerupted permanent canine crossing the midline is called transmigration and is an unusual event. We report nine cases of impacted canine transmigration. Maxillary canine transmigration, bilateral transmigration, and transmigration associated with odontoma are rare presentations. This article discusses the varied clinico-radiologic presentations, etiology, and treatment options of transmigration. It also emphasizes the importance of panoramic radiographs for evaluation of over-retained deciduous canines or missing permanent canines.

  13. Clinico-pathological features of kidney disease in diabetic cases.

    Science.gov (United States)

    Furuichi, Kengo; Shimizu, Miho; Okada, Hirokazu; Narita, Ichiei; Wada, Takashi

    2018-03-21

    Diabetic kidney disease is the major cause of end-stage kidney disease in developed countries. However, the onset of kidney disorder and the progression pattern of kidney dysfunction and proteinuria greatly vary cases by cases. Therefore, risk classification with clinical data and pathological findings is important. Recent clinico-pathological study with kidney biopsy samples from diabetic patients revealed that pathological changes of diabetic nephropathy are characteristic and have special impacts on prognosis in each clinical stage. Moreover, comparison of the clinico-pathological findings of diabetic nephropathy with hypertensive nephrosclerosis revealed that there are few differences in their pathological findings in cases with low albuminuria and preserved estimated glomerular filtration rate (eGFR). Because it is so difficult to clearly distinguish pure kidney lesions caused by diabetes and kidney lesions due to effects other than diabetes, it is vital that these overlapped pathological findings be confirmed on kidney biopsy in cases of early stage diabetes. Further research is warranted regarding the pathogenesis of diabetic nephropathy and indication of kidney biopsy in diabetic cases.

  14. Solitary pulmonary nodule: radiologic features and diagnostic approach; Nodulo pulmonar solitario: caracteristicas radiologicas y abordaje diagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Cambronero, Luis Enrique

    2012-07-01

    A literature review is conducted on the solitary pulmonary nodule, to determine the diagnostic methods and specific characteristics. The diagnostic methods used have been: chest radiography, computed tomography, positron emission tomography and magnetic resonance imaging. The radiological features are defined: location, size, definition of contours or edges (margins), densitometric and attenuation characteristics, cavitation, air bronchogram, growth, doubling time, satellite nodules, nutrient vessels [Spanish] Una revision bibliografica es realizada sobre el nodulo pulmonar solitario, para determinar los metodos de diagnostico y caracteristicas especificas. Los metodos de diagnostico utilizados han sido: la radiografia de torax, tomografia computarizada, tomografia por emision de positrones y resonancia magnetica. Las caracteristicas radiologicas son definidas: localizacion, tamano, definicion de los bordes o contornos (margenes), caracteristicas densitometricas y de atenuacion, cavitacion, broncograma aereo, crecimiento, tiempo de duplicacion, nodulos satelite, vasos nutrientes.

  15. Aplastic anemia: clinico haematological features, treatment and outcome analysis

    International Nuclear Information System (INIS)

    Wali, R.; Fadoo, Z.; Naqvi, M.A.

    2011-01-01

    To determine the clinico haematological features, treatment and outcome of children diagnosed with aplastic anemia at a single institution. Study Design: Observational study. Place and Duration of Study: The Aga Khan University Hospital, Karachi, from January 1999 till December 2008. Methodology: Medical records of children aged less than 15 years of age diagnosed with aplastic anemia were reviewed. Clinico haematological features, treatment and its response to therapy and outcome were recorded. Results were described in percentages. Results: Ninety patients were diagnosed to have aplastic anemia (AA); 65 were male during the study period. Age ranged from 1 to 15 years. Fever in 65 patients (72.2%), pallor in 53 (58.8%), skin bleeding in 49 (54.4%) and epistaxis in 31(34.4%) were the most common and frequent presenting features. Congenital (Fanconi's) anemia was found in 15 (16.6%) and acquired idiopathic in 75 (83.4%) of patients. Very severe aplastic anemia (VSAA) was seen in 29 (32.2%), 26 (28.9%) had severe AA and 17 (18.9%) had moderate AA. Eight patients (8.9%) underwent haematopoietic stem cell transplantation (HSCT), 12 (13.3%) received immunosuppressive therapy (IST) and 70 patients (77.7%) received other and supportive therapy. Five (62.5%) patients showed complete response to HSCT and 3 (37.5%) failed to engraft. IST showed complete response in 3 (25%), partial response in 5 (41.6%) and no response in 4 (33.3%). Twenty two patients (24.4%) expired either due to infection in 16 (72.7%, fungal in 6, bacterial in 10) and intracranial haemorrhage in 6 (27.3%) cases. Conclusion: Majority of cases with AA were acquired and idiopathic in etiology. VSAA and SAA were frequent. Response to HSCT and IST was sub-optimal. (author)

  16. Pericoronal radiolucencies with significant pathology: Clinico-histopathologic evaluation

    Directory of Open Access Journals (Sweden)

    Sanjeev Anand

    2015-04-01

    Full Text Available Background: The purpose of the study was to correlate the provisional diagnosis of pericoronal radiolucencies associated with impacted, embedded, or unerupted teeth with the histopathologic diagnosis, and also to emphasize the importance of early detection for better diagnosis and management. Methods: This is a retrospective study involving 18 cases of pericoronal radiolucencies associated with unerupted, embedded, or impacted teeth whose data during 1-year period were retrieved, and were reviewed for clinical, radiological, and histopathologic data. Also, comparison and correlation of clinico-histopathologic diagnosis was made. Results: Of the 18 cases, 11 were provisionally diagnosed as dentigerous cyst and the remaining were diagnosed as ameloblastoma, odontogenic keratocyst, adenomatoid odontogenic tumor, and calcifying epithelial odontogenic cyst. Histopathologic diagnosis of the 18 cases showed varied results, with only 10% correlating with the provisional diagnosis. Conclusion: Although many pathological processes may present radiographically as pericoronal radiolucencies associated with unerupted teeth, the most common is the dentigerous cyst. Hence, it is crucial for the clinician to fully investigate all teeth that fail to erupt at the expected time, and promptly initiate appropriate assessment and management of suspected cystic lesions.

  17. Chordoma: review of clinico radiological features and factors affecting survival

    International Nuclear Information System (INIS)

    Soo, M.Y.S.

    2001-01-01

    This study reviews the clinico radiological features of cranial and sacrospinal chordomas and identifies factors affecting survival. Nineteen patients seen between January 1980 and December 2000 with histopathological diagnosis of chordomas were retrospectively reviewed with reference to clinical presentation, imaging features, treatment modalities and post-therapy status. Eight had tumours in the skull base while 11 patients had spinal and sacro-coccygeal lesions. Surgical resection was performed in 16 patients whose subsequent natural history was used to identify clinical indicators that may influence survival. Completeness of resection, age, gender and postoperative irradiation were subjected to analysis using the Cox proportional hazard models. Kaplan-Meir survival curves illustrate the survival distributions. Diplopia and facial pain are prime clinical presentations in cranial lesions, while extremity weakness and a sacrogluteal mass are common complaints in the sacrospinal group. Lesional calcifications are present in 40% while an osteolytic soft tissue mass is detectable by CT in all cases. Heterogeneous signals and internal septations on T 2 -weighted MRI are predominant features. In sacrospinal tumours, complete excision with adjuvant radiotherapy achieves the best results with a disease-free survival of more than 5 years. The clinical and imaging findings in this study are in accordance with those of other series. Except for complete surgical excision followed by radiotherapy in the subset of patients with sacrospinal tumours, none of the other clinical indicators show a statistical significant influence on survival. Copyright (2001) Blackwell Science Pty Ltd

  18. Ulcerative Granular Cell Tumor: A Clinico pathological and Immunohistochemical Study

    International Nuclear Information System (INIS)

    El-Khalawan, M.; Mosbeh, A.; Abd-Al Salam, F.; Abou-Bakr, A.

    2011-01-01

    Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinico pathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study included 11 males and 3 females with a mean age 31.5± 7.42 years. All cases were presented with large solitary ulcer with indurated base, elevated border, skin colored margin, and necrotic floor. Twelve lesions were located on the extremities and two lesions on the genital region. Histologically, the lesions showed dermal infiltrate composed of large polygonal cells with granular cytoplasm and characteristic infiltration of the dermal muscles in all cases. Immunostaining showed positive reaction for S100 (14/14), NSE (14/14), CD68 (5/14), and Vimentin (7/14) while HMB45, CK, EMA, and Desmin were negative. We hope that this paper increases the awareness of ulcerative GCT and consider it in the differential diagnosis of ulcerative lesions

  19. A Clinico-epidemiologic Profile of Herpeszoster in Norht India

    Directory of Open Access Journals (Sweden)

    S D Chaudhary

    1987-01-01

    Full Text Available A clinico-epidemiological study of 230 cases of herpes zoster revealed an overallincidence of 0.6 percent. Out of 230 patients 160 were males and 70 females (male and female ratio being 2.2:1. The maximum incidence was noted in the second and third decades. A higher incidence was observed in the months of March, April, May and then in August, September and October. A confirmative history of chicken poxin the past was available in 34 (14.7% patients only. There was no appreciable difference between right and left side involvement, except for the cranial segments, where the right side was predominantly involved. Thoracic segments were most commonly (55.2% involved followed by cervical (19.5%, lumbo-sacral (13.9% , and cranial (11.3% segments. Prodromal symptoms were recorded in 20% patients. Among the cranial nerves, ophthalmic branch of trigeminal nerve was most commonly (57.7% affected. Post herpetic neuralgia was noticed in 14.3% patients.

  20. A clinico-epidemiological study of herpes zoster.

    Science.gov (United States)

    Aggarwal, S K; Radhakrishnan, S

    2016-04-01

    Herpes zoster is a common viral infection of skin caused by reactivation of varicella zoster virus infection from the spinal ganglia. The clinico-epidemiological patterns of this disease in an Indian setting required to be studied. A cross sectional study was conducted on all consecutive cases of herpes zoster reporting to the Dermatology Outpatient Department at a Tertiary Care Hospital in Bangalore during a period of one year from 01 Jun 2013 to 31 May 2014. Detailed history, examination, HIV screening and Tzanck smear were carried out in all cases. 84 cases of herpes zoster were seen with a mean age of 30 years. Majority (39%) of cases were seen in the 21-30 year age group. Thoracic segments were involved in 65.4%, cervical in 11.9%, cranial in 11.5%, lumbar in 8.3% and sacral segments in 3.5%. 63% of cases had zoster associated pain. One case had motor involvement.3.57% of the patients were HIV positive. This study shows a lower age incidence of herpes zoster HIV positivity and zoster associated pain as compared to other studies. The pattern of segmental involvement in herpes zoster seen in this study was similar to other studies.

  1. Intraocular osseous metaplasia. A clinico-pathological study.

    Science.gov (United States)

    Vemuganti, Geeta K; Honavar, Santosh G; Jalali, Subhadra

    2002-09-01

    To evaluate the clinico-pathologic features of intraocular osseous metaplasia. Pathology specimens of enucleated eyes submitted to the ophthalmic pathology service at a tertiary eye-care referral center between January 1995 and June 1999 were studied for intraocular osseous metaplasia. Specific histopathologic features noted in specimens with osseous metaplasia were the presence of retinal detachment, gliosis, retinal pigment epithelial hyperplasia, drusen, epiretinal membrane, fibrovascular proliferation and inflammation. Immunohistochemistry using monoclonal antibody against glial fibrillary acidic protein was performed to assess the glial component within the membranes and the proliferative vitreoretinal mass. Clinical records were reviewed and correlated with histopathologic findings. Osseous metaplasiaS was noted in 8 of 151 (5.2%) eyes examined. Clinical diagnosis in these was phthisis bulbi, staphyloma, absolute glaucoma and microphthalmos. Enucleation was performed for relief of symptoms (in painful blind eyes) or for cosmesis, and in an eye inciting sympathetic ophthalmia. Retinal detachment, gliosis and retinal pigment epithelial hyperplasia were noted in all the cases. Drusen with calcification or ossification (5 of 8), fibrovascular proliferation in the vitreous (5 of 8) and active inflammation (4 of 8) were the other associated histologic features. Location of ossification was subretinal in 3 cases, preretinal (ora serrata) in 1 case and in both locations in 4 cases. The eyes with subretinal osseous metaplasia had associated calcified drusen, while preretinal ossification was seen within the fibrovascular membranes. Chronic retinal detachment, hyperplasia and transdifferentiation of retinal pigment epithelium appear to be a few of the prerequisites for intraocular osseous metaplasia. Ossification can occur at isolated subretinal and preretinal locations or can involve both. Though a larger study is required to postulate the chronology of events, in

  2. Intraocular osseous metaplasia. A clinico-pathological study

    Directory of Open Access Journals (Sweden)

    Vemuganti Geeta

    2002-01-01

    Full Text Available Purpose: To evaluate the clinico-pathologic features of intraocular osseous metaplasia. Methods: Pathology specimens of enucleated eyes submitted to the ophthalmic pathology service at a tertiary eye-care referral center between January 1995 and June 1999 were studied for intraocular osseous metaplasia. Specific histopathologic features noted in specimens with osseous metaplasia were the presence of retinal detachment, gliosis, retinal pigment epithelial hyperplasia, drusen, epiretinal membrane, fibrovascular proliferation and inflammation. Immunohistochemistry using monoclonal antibody against glial fibrillary acidic protein was performed to assess the glial component within the membranes and the proliferative vitreoretinal mass. Clinical records were reviewed and correlated with histopathologic findings. Results: Osseous metaplasiaS was noted in 8 of 151 (5.2% eyes examined. Clinical diagnosis in these was phthisis bulbi, staphyloma, absolute glaucoma and microphthalmos. Enucleation was performed for relief of symptoms (in painful blind eyes or for cosmesis, and in an eye inciting sympathetic ophthalmia. Retinal detachment, gliosis and retinal pigment epithelial hyperplasia were noted in all the cases. Drusen with calcification or ossification (5 of 8, fibrovascular proliferation in the vitreous (5 of 8 and active inflammation (4 of 8 were the other associated histologic features. Location of ossification was subretinal in 3 cases, preretinal (ora serrata in 1 case and in both locations in 4 cases. The eyes with subretinal osseous metaplasia had associated calcified drusen, while preretinal ossification was seen within the fibrovascular membranes. Conclusion: Chronic retinal detachment, hyperplasia and transdifferentiation of retinal pigment epithelium appear to be a few of the prerequisites for intraocular osseous metaplasia. Ossification can occur at isolated subretinal and preretinal locations or can involve both. Though a larger study is

  3. Clinico-hemato-biochemical profile of dogs with liver cirrhosis

    Directory of Open Access Journals (Sweden)

    M. A. Elhiblu

    2015-04-01

    Full Text Available Aim: The aim of this study was to determine the relevant tools in the diagnosis of liver cirrhosis in dogs. Material and Methods: A total of 140 dogs presented at Veterinary Teaching Hospital, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, showing clinical signs of hepatic insufficiency were subjected to clinico-hemato biochemical, urological, ultrasonographic (USG, and USG guided fine-needle biopsy examinations by standard methods. On the basis of these results, 6 dogs out of 140 dogs were found to be suffering from liver cirrhosis. Six clinically healthy dogs constituted the control group. Results: The dogs suffering from liver cirrhosis manifested inappetence, halitosis, abdominal distension, weight loss, melena, icterus, anemia, and neutrophilic leukocytosis with the left shift. Levels of hemoglobin, lymphocytes, packed cell volume, mean corpuscular volume, mean corpuscular Hb (MCH, and platelet count were significantly lower in liver cirrhosis group than control group while total leukocyte count, neutrophils, and MCH concentration were significantly higher. Glucose, total protein, albumin, A/G ratio, and fibrinogen were significantly lower, and creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, prothrombin time, and APTT were significantly higher than the control values. Ultrasound revealed diffuse increase in echogenicity with rounded and irregular liver margins. Cytological examination of the ascitic fluid and fine-needle aspiration biopsy of liver was not fruitful in the diagnosis of liver cirrhosis. Conclusions: Liver cirrhosis causes clinical and hemo-biochemical alterations, which require special consideration when treating diseased animals. USG, diffuse increase in echogenicity of liver, rounding and irregularity of liver margins and microhepatica were the consistent findings. It is suggested that USG along with hemo-biochemical alterations may be used as a diagnostic tool for

  4. Prevalence and Clinico-Pathology of Ketosis in Dairy Cows in Tigray ...

    African Journals Online (AJOL)

    Tadesse

    An investigation to study the prevalence and clinico-pathology of ketosis in dairy cows ... The clinical observations in ketotic cows were anorexia, refusal to .... The decrease in milk yield was 36-100% in 5 cases followed by 30-36% in 5 cases.

  5. [The clinico-psychopathological differentiation of schizoaffective psychoses with a predominance of affective disorders].

    Science.gov (United States)

    Korenev, A N

    1994-01-01

    Basing on the clinico-psychopathological analysis of 43 patients with an affect-dominant form of schizoaffective psychosis, their typological division has been suggested. The interrelations of clinical types of delusional disturbances with affective disorders, their polarity, congruent and noncongruent delusions were shown. The discussion covers differential-diagnostic characteristics of affective states in schizoaffective and affective psychoses.

  6. Clinico pathological presentation of tongue cancers and early cancer treatment

    International Nuclear Information System (INIS)

    Najeeb, T.

    2006-01-01

    Objective: To analyze clinico pathological presentation of tongue cancers and to calculate survival rates (SR) with disease free survival rates (DFSR) and recurrence rates (RR) in different treatment modalities and to compare the results of surgery alone and radiotherapy alone in stage I and stage II disease and to calculate better option of treatment in early tongue cancers. Design: A longitudinal study. Place and Duration of Study: Department of Otolaryngology and Head and Neck Surgery, Pakistan Institute of Medical Sciences, Islamabad (PIMS) from January 1987 to June 1998. Patients and Methods: Case histories of 67 patients were collected from departmental record. Clinical data included age at diagnosis, gender of patient, location of tumor, presenting symptoms and their duration, biopsy report, predominant histological pattern of tumor, nodal status, stage of tumor, treatment modality employed, tumor recurrence, metastasis and survival rates with disease-free survival rates after 2 years' follow-up. Results: Among 67 patients there were 31 males and 36 females. Mean age was 50 years (range 20 - 80 years). Sixty seven patients with primary cancer of tongue constituted 38.8% of oral cavity cancers during period of 1987 - 1998 in PIMS. Smoking, poor oro dental hygiene (POOH) and betel nuts chewing were the main risk factors. Odynophagia and painful ulcers on lateral border of tongue were the main clinical symptoms with average duration of 7 months. Regional lymph nodes were palpable in 32.8%, 5.5% was in stage I, 35.8% in stage II, 29.8% in stage III, and 28.3% was in stage IV. No patient was found to have distant metastasis. Histopathology in 94% of cases was squamous cell carcinoma (SCC). Recurrence and survival rates were determined in 49 patients. Average time of recurrence was 12.5 months. Recurrence was 100% loco regional (LR). It was 85.7% in patients treated with radiotherapy (RT) alone, 42.1% in patients treated with surgery alone and 31.2% in patients

  7. [Autosomal-recessive renal cystic disease and congenital hepatic fibrosis: clinico-anatomic case].

    Science.gov (United States)

    Rostol'tsev, K V; Burenkov, R A; Kuz'micheva, I A

    2012-01-01

    Clinico-anatomic observation of autosomal-recessive renal cystic disease and congenital hepatic fibrosis at two fetuses from the same family was done. Mutation of His3124Tyr in 58 exon of PKHD1 gene in heterozygous state was found out. The same pathomorphological changes in the epithelium of cystic renal tubules and bile ducts of the liver were noted. We suggest that the autopsy research of fetuses with congenital abnormalities, detected after prenatal ultrasonic screening, has high diagnostic importance.

  8. Ricerca clinico-epidemiologica sullo stato di salute del cavo orale nei pazienti tossicodipendenti

    OpenAIRE

    Bromo, Francesco

    2010-01-01

    Obiettivo: Lo scopo della ricerca è stato quello di mettere in evidenza la presenza di patologie del cavo orale in soggetti tossicodipendenti Materiali e Metodi: Sono stati reclutati 71 pazienti in terapia di recupero presso la Comunità Incontro di Amelia. I soggetti sono stati sottoposti a visite clinico-anamnestiche adottando una cartella clinica da noi stessi costruita. Risultati: Dei 71 soggetti tossicodipendenti, 42 facevano uso di eroina e 39 assumevano droghe per v...

  9. Optimization of the standards clinico-neurology and beam diagnostics of an easy brain injury

    International Nuclear Information System (INIS)

    Vakulenko, I.P.; Semisalov, S.Ya.; Sajko, D.Yu.

    2003-01-01

    16825 cases of a brain injury (BI) at the persons are investigated is more senior than 14 years. Axial computer topography (ACT) at concussion of a head brain was made 1/3 injureds. The careful analysis clinico-neuralgic symptoms allows to optimize purpose the ACT at easy BI, that not only improves quality of diagnostics, but in the certain degree normalizes beam loading on the injureds

  10. National subprogram 'Sistema Nacional de Vigilancia Radiologica Ambiental y de los Alimentos en la Republica de Cuba'

    International Nuclear Information System (INIS)

    Fernandez Gomez, Isis Maria

    2008-01-01

    The purpose of this work is to inform and raise awareness about the Sistema Nacional de Vigilancia Radiologica Ambiental y de los Alimentos in the Republica de Cuba. The radiological environmental monitoring is defined as the assessment of current or potential exposure of the population to radiation and radioactive materials released into the environment. It determines when is required the radiological environmental monitoring, what is a radiological environmental monitoring program, which are the points to consider during the design of this kind of program and what are their objectives. In addition, the program on the Republica de Cuba is focused, referring to the components of a radiological environmental monitoring program; equipment for the detection of radiations; the procedures for collecting environmental samples and laboratory analysis capabilities. It also noted the techniques of radiological environmental monitoring and is described extensively the Red Nacional de Vigilancia Ambiental of the Republica de Cuba. Likewise, it is included the table on radiological monitoring of food and water. Other radiological monitoring programs in Cuba are commented as the radiological control of industrial scrap [es

  11. Students perception about the clinico-anatomical conferences as a teaching methodology

    International Nuclear Information System (INIS)

    Saeed, K.; Baptist, M.; Mukhtar, F.

    2015-01-01

    Anatomy has always been considered as an essential basis for clinical sciences. In recent decades there has been an increased trend towards incorporation of clinical problems in the teaching of anatomy. To promote clinical knowledge clinico-anatomical conferences have been conducted in our department for the last five years. This study has been undertaken to determine perception of medical students regarding these conferences and to formulate recommendations for their improvement based on feedback obtained from students. Method: A cross-sectional study was conducted from December 2013 to January 2014 at the Lahore Medical and Dental College (LMDC), Lahore. A sample of 200 students of first and second year MBBS classes was selected for the study through convenience sampling technique. A 5-point Likert scale ranging from 1 (strongly agree) to 5 (strongly disagree) was used to determine students perception about clinic-anatomical conferences, using a self-administered questionnaire. Data was analysed using SPSS-19.0. Results: Out of total 144 (72%) students were of the opinion that clinico-anatomical conferences were a good source of clinical knowledge, 126 (63%) opined that these conferences promoted understanding rather than memorization, 122 (61%) found them interesting, and 15 (30%) found improvement in their grades in the subject of anatomy after attending the conferences. Conclusion: The clinico-anatomical conferences were found interesting and reported to be a good source of clinical knowledge. It is recommended that these conferences should be conducted frequently, made interactive and patients should be presented as case studies during the conferences. (author)

  12. Papers of the Fifth Annual Congress of the Sociedad Mexicana de Seguridad Radiologica, A.C., 2. Regional Congress on Radiological and Nuclear Safety. Vol. 2 (pt.2)

    International Nuclear Information System (INIS)

    1993-11-01

    The fulfillment of the Fifth Annual Congress of the Sociedad Mexicana de Seguridad Radiologica, A.C., this time inside the frame of the Second Regional Congress of Radiological and Nuclear Safety, is no doubt an event that approach us to make of this forum the most important for the exchange of ideas and the approaching among the members of our nuclear community. This time, the beautiful colonial city of Zacatecas, welcome us for this event, gathering fifty works in the areas of fuel cycle, power reactor operation, reactor physics, research reactors, transient analysis and instrumentation and experimental techniques. This significant number of works reaffirm the great interest of the nuclear community in to take part, presenting its most recent developments. The reporting belongs to seven of the main institutions of the country who dedicate, or are related with the technological development of the nuclear area and its different branches. With regard to participants of foreign countries, papers representing to Argentina, Brazil, Chile, United States of North America and Peru are included. The efforts of all the members of the Sociedad Mexicana de Seguridad Radiologica, A.C. has been addressed to do of the event a mean to make easy the exchange of ideas and to get acquainted with the work of other colleagues, in an ambient of warmth and surmounting. (Author)

  13. Onychomycosis: Clinico-mycologic study of 130 patients from Himachal Pradesh, India

    Directory of Open Access Journals (Sweden)

    Gupta Mudita

    2007-01-01

    Full Text Available Background: Onychomycosis is a common nail infection caused by dermatophytes, yeast or other nondermatophyte molds and has diverse clinical presentations. Although common in this part of the country, no significant clinico-mycologic data is available. Objectives: This study was carried out to document the clinico-mycologic pattern of onychomycosis in Himachal Pradesh (India. Methods: All consecutive patients of onychomycosis diagnosed clinically during March 2005 to February 2006 were studied for clinical forms, number of nails involved and severity of infection. The clippings from the most severely affected nails were subjected to potassium hydroxide (KOH mounts for direct microscopy and fungal culture on Sabouraud′s dextrose agar. Results: These 130 patients (M:F 98:32 were between 8-76 years of age (mean 41.35 ± 14.98 years. The prevalence of onychomycosis was higher among farmers and office workers (20% each. Finger or toe nails were exclusively involved in 56.9 and 32.3% patients respectively while these were involved concurrently in the rest of the 10.8% patients. Distal and lateral subungual onychomycosis seen in 73.1% of the specimens was the most common clinical type. KOH- and culture-positivity were recorded in 59.2 and 37.6% cases respectively. Dermatophytes and yeast (Candida albicans were isolated in 40.8% each of the cultured nail specimens while nondermatophytic molds (NDM were cultured in 18.6% of the samples. Various dermatophytes cultured were Trichophyton rubrum (32.6%, T. mentagrophytes (6.1% and T. verrucosum (2.1% respectively. Aspergillus spp. (6.1% was the most commonly isolated NDM while other detected molds were Acremonium spp., Fusarium spp,, Scopulariopsis spp., Curvularia spp. and Penicillium marneffei. Peripheral vascular disorders (7.69%, occupational trauma (13.8%, close association with animals (60.78% and a family history of onychomycosis (26.15% were a few of the predisposing factors identified. Conclusion

  14. [Peculiarities of clinico-neurological signs of the intervertebral discs protrusions in lumbar portion of vertebral column in patients of various age].

    Science.gov (United States)

    Khyzniak, M V; Pryĭmak, E V

    2013-11-01

    Clinico-neurological signs of the discogenic pain syndromes, caused by intervertebral disc (IVD) protrusion in a lumbar portion of vertebral column, were analyzed. The strict indications were substantiated for application of the puncture treatment methods for the discogenic pain syndromes in patients of various ages. Clinico-neurological signs of the IVD protrusions constitute the important criterion while the treatment method selection. Differentiated application of the puncture methods permits to improve the treatment results in the patients of various age.

  15. Clinico-pathological studies of CSF dissemination of glioblastoma and medulloblastoma

    International Nuclear Information System (INIS)

    Kato, Kyozo; Yoshida, Jun; Kageyama, Naoki

    1986-01-01

    Clinico-pathological findings of CSF dissemination which was diagnosed on CT scan, were studied on 13 cases of glioblastoma and 9 cases of medulloblastoma. The type of CSF dissemination and the prognosis of patients were both different between glioblastoma and medulloblastoma. In the former, the dissemination was predominantly in ventricular walls and in the latter, in basal cisterns. The mean survival time after the diagnosis of dissemination is 6 months of glioblastoma as compared with 13 months of medulloblastoma. The Pathological studies show that subependymal and/or subpial infiltration of tumor cells, and thickness of arachnoid membrane by marked mesodermal reaction were demonstrated in cases of glioblastoma. On the contrary, tumor cells of medulloblastoma grow markedly in the subarachnoid space and/or on the ependymal layers. From these pathological findings of CSF dissemination, it will be resulted that the prognosis of glioblastoma is much more poor that of medulloblastoma. (author)

  16. [Clinico-morphological peculiarities of thyroid cancer among children exposed to the Chernobyl disaster radiation].

    Science.gov (United States)

    Iakovleva, I N; Shishkov, R V; Poliakov, V G; Pankova, P A

    2008-01-01

    The paper deals with a comparison of clinico-morphological patterns of sporadic thyroid cancer and that in pediatric patients exposed to radiation during the Chernobyl disaster. The latter are highly prone to both local and regional metastatic spread to the lymph nodes (intrathyroid distribution--61%; extension through capsule--42%, and metastases to the neck lymph nodes--66%). However, these data do not differ significantly from those for intact areas. Yet, cancer occurs in exposed cohorts at an earlier stage: its incidence at age 4-6 is 2-3.5 higher and that of relapse such as presentation of latent metastases to the lymph nodes and tumor foci development in residual tumor tissue is 1.6 times the average. Also, morphological patterns have changed: typical papillary cancer incidence has dropped by half while the diffuse follicular variety has grown 1.8-fold.

  17. Screenings of lung cancer with low dose spiral CT: results of a three year pilot study and design of the randomised controlled trial Italung-CT; Screening della neoplasia polmonare con TC spirale a bassa dose: risultati di uno studio pilota triennale e disegno dello studio clinico randomizzato Italung-CT

    Energy Technology Data Exchange (ETDEWEB)

    Picozzi, Giulia [Firenze Univ., Firenze (Italy). Radiodiagnostica I-Dipartimento di Fisiopatologia Clinica; Paci, Enrico [Azienda Ospedaliera Universitaria di Careggi, Firenze (Italy). Unita' di Epidemiologia Clinica e Descrittiva Centro per lo Studio e la Prevenzione Oncologica; Lopes Pegna, Andrea [Azienda Ospedaliera Universitaria di Careggi, Firenze (Italy). U.O. Pneumologia] [and others

    2005-02-01

    multislice. Per la gestione clinico-radiologica dei noduli indeterminati riscontrati sono state seguite le raccomandazioni dell'Early Lung Cancer Action Project. Risultati: Complessivamente, sono stati riscontrati noduli indeterminati in 33 (55%) soggetti (60% alla TC di base, 24% al primo controllo annuale e 16% al secondo). Il nodulo di maggiori dimensioni aveva un diametro <5mm in 20 soggetti, in 10 dei quali il nodulo veniva rilevato all'esame di base. Quarantacinque (75%) soggetti hanno effettuato il primo controllo annuale e quarantadue (70%) il secondo. Sono stati riscontrati un tumore polmonare prevalente (1,6%) (carcinoma adenosquamoso), un tumore polmonare incidente (2,2%) (un tumore a piccole cellule, al primo controllo annuale), ed una localizzazione polmonare di un linfoma di Hodkin (al secondo controllo annuale). Inoltre un soggetto e' stato sottoposto ad intervento chirurgico polmonare per amartocondroma. Conclusioni: I risultati dello studio pilota sono sostanzialmente in linea con quelli di altri studi osservazionali su campioni di maggiori dimensioni e sono tali da giustificare ottimismo circa la affidabilita' dei risultati che saranno ottenuti nel braccio attivo dello studio randomizzato Italung-CT appena iniziato.

  18. Clinico-Histopathological Spectrum of Infectious Granulomatous Dermatoses in Western India- A Representative Study from Mumbai.

    Science.gov (United States)

    Grover, Sumit; Agale, Shubhangi Vinayak; D'Costa, Grace F; Valand, Arvind G; Gupta, Vikram Kumar

    2016-04-01

    Infectious Granulomatous Dermatoses (IGDS) have various aetiological factors with a considerable overlap in the histopathological and clinical features, thus posing a diagnostic dilemma for dermatologists and pathologists. We aimed at determining the histopathological profile of IGDS correlating it with clinical features with an attempt to find the aetiology. In a cross-sectional study conducted in a tertiary referral center of Mumbai over two years, out of 1872 skin biopsies received, 239 histopathologically diagnosed cases of IGDS were studied for histopathological features of granuloma. A clinico-histopathological correlation was attempted. Chi-square test was used for comparison of proportions of different groups. Leprosy (211 cases) and tuberculosis (28 cases) were the commonest histopathologically diagnosed IGDS. Leprosy spectrum included BT (30.33% cases), followed by TT (21.32%), BL and LL and 21.79% cases of lepra reactions. Skin TB biopsies on histopathology showed lupus vulgaris (53.85% cases), scrofuloderma (15.38%), TBVC and papulonecrotic tuberculid (11.54% each). In leprosy maximum clinico-pathological agreement was seen at tuberculoid pole (TT 72.7% and BT 56.6%). Among tuberculosis cases, scrofuloderma (100%) and lupus vulgaris (53.8%) showed maximum agreement. Leprosy and skin TB are the commonest IGDS in Mumbai region though difficult to diagnose and subcategorize with certainty during initial stages. Histopathology plays the important role to elucidate the dilemma. This being a single center study, more such studies with a larger sample size are recommended to get more elaborate data and regional prevalence of these IGDS for a better overall approach to prevention, treatment and control.

  19. A clinico-pathological study of 163 untreated cases of chronic hepatitis C

    Directory of Open Access Journals (Sweden)

    Joachim Graf

    1996-02-01

    Full Text Available We performed a clinico-pathological study of 163 untreated cases of chronic hepatitis C. Eighty five percent of the patients were clinically asymptomatic and their physical examinations sbowed unremarkable or minimal changes at the time of the liver biopsy Liver function tests tended to present slight abnormalities, involving mild elevations of the activity of the aminotransferases and gamma-glutamil transferase levels. In spite of these mild abnormalities advanced chronic liver disease ivas histologically detected in eighty nine percent of the patients, mainly showing chronic active hepatitis. The most characteristic histological finding ivas an interlobular bile duct damage which correlated with the presence of tymphoid aggregates in the portal tracts and with the development of fibrosis.Realizou-se estudo clinico-patológico de 163 casos não tratados de hepatite crônica C. A maioria dos pacientes era clinicamente assintomática e seus exames físicos demonstravam alterações inespecíficas ou mínimas por ocasião da biópsia hepática. As provas de função hepática tendiam a apresentar alterações discretas, envolvendo especialmente os níveis séricos das aminotransferases e gama-glutamil transpeptidase. Apesar destas alterações discretas, detectou-se doença hepática crônica histologicamente avançada, consistindo principalmente de hepatite crônica ativa. O achado histológico mais característico foi lesão de dueto biliar interlobular, que se correlacionou com a presença de agregados linfóides nos tratos portais e com o desenvolvimento de fibrose.

  20. Incidental benign parotid lesions on FDG-PET: prevalence and clinico-pathologic findings

    International Nuclear Information System (INIS)

    Lim, Il Han; Lee, Won Woo; Chung, Jin Haeng; Park, So Yeon; Kim, Sang Hee; Kim, Yu Kyeong; Kim, Sang Eun

    2007-01-01

    Incidental parotid lesions on F-18 FDG-PET can mimic distant metastasis of underlying malignancy. The prevalence and the clinico-pathologic findings of PET positive parotid lesions have not been known. We investigated how often incidental parotid lesions are found on clinical FDG-PET studies and what the clinico-pathologic characteristics of those parotid lesions are in the present study. We retrospectively reviewed 3,344 cases of FDG-PET which had been obtained in our hospital from May 2003 to Dec 2006. The indications of FDG-PET were: evaluation of known/suspected cancer (n = 3,212) or screening of cancer in healthy subjects (n = 132). Incidental parotid lesion on FDG-PET was defined as an un-expected FDG uptake in one of parotid glands which was not primary target lesion of current FDG/PET. FDG uptake was represented by maximum standardized uptake value (maxSUV). Final diagnosis was made by pathologic analysis or clinical follow-up assessment. Fifteen (0.45% = 15/3,344) incidental parotid lesions were found and they were all benign lesions. The maxSUV ranged from 1.7 to 8.6 (mean ± s.d. = 3.7 ± 1.9). Final diagnoses of the incidental parotid lesions were; Warthin's tumor (n = 2), pleomorphic adenoma (n = 1), other un-specified benign lesion (n 1), and benign lesions under bases of imaging studies (n = 3) and of clinical follow-up (n = 8). All of incidentally found parotid lesions in clinical FDG-PET studies were confirmed as benign lesions with prevalence of 0.45%. Close follow up using PET or CT might be a reasonable approach for determining the nature of incidentally found parotid lesions

  1. Modified Mason's vertical banded gastroplasty. Radiological follow-up 322 patients with morbid obesity; Ruolo della radiologia nella valutazione dei pazienti affetti da obesita' patologica sottoposti a gastroplastica verticale secondo Mason modificata. Studio di 322 casi

    Energy Technology Data Exchange (ETDEWEB)

    Monteduro, F.; Cappello, I.; Pezzi, A.; Spagnol, A. [Bologna Univ., Bologna (Italy). Policlinico S. Orsola, Servizio Radiologia 2; Ghetti, A. [Bologna Univ., Bologna (Italy). Clinica Chirurgica 2

    1999-12-01

    the neo stomach and permit to correlate the pouch volume with weight loss. [Italian] La gastroplastica verticale secondo Mason rappresenta una delle tecniche piu' utilizzate nel trattamento dell'obesita' patologica in quanto ha semplice esecuzione, buoni risultati e scarsa incidenza di complicanze a distanza. Nel presente lavoro venogno presentati i risultati del controllo radiologico postoperatorio condotto su 322 pazienti sottoposti a gastroplastica verticale secondo Mason modificata. In 322 pazienti sottoposti a gastroplastica verticale secondo Mason modificata sono state valutate mediante studio radiologico con pasto semiliquido e tecnica con mdc semplice le caratteristiche morfologiche, funzionali e volumetriche della tasca gastrica e le eventuali complicanze dell'intervento. Di questi 322 pazienti 272 erano femmine con eta' compresa tra 17 e 69 anni (media 37) e 50 maschi con eta' compresa tra 19 a 64 anni (media 36); il peso medio era di 124 kg (con intervallo da 78 a 218). Solo nei pochi casi in cui e' risultata necessaria la valutazione dettagliata della mucosa del neostomaco e' stato utilizzato il doppio mdc on minime dosi di polvere effervescente. La valutazione e' stata effettuata dopo uno e 12 mesi dall'intervento. Controlli al di fuori di questo protocollo sono stati effettuati solo su precisa indicazione clinica per sospetta insorgenza di complicanze compreso il non adeguato calo ponderale. Nella nostra serie si sono osservate 9 complicanze precoci: edema persistente dello pseudopiloro (8 casi) ed emorragia endogastrica (un caso) e 8 complicanze tardive: aderenza dello pseudopiloro al letto della colecisti (un caso), formazione di pseudo-diverticolo della parete posteriore del neostomaco (un caso), orizzontalizzazione del neostomaco (4 casi), deiscenza della sutura lineare (2 casi). In 305 pazienti non si e' avuta nessuna complicanza con calo ponderale soddisfacente e volumetria del neostomaco uno e

  2. Loss of Maspin Expression in Bladder Cancer: Its Relationship with p53 and Clinico pathological Parameters

    International Nuclear Information System (INIS)

    Abd El-Maqsoud, N.M.R.; Tawfiek, E.R.

    2010-01-01

    Maspin (mammary serine protease inhibitor) is a member of the serpin super family of protease inhibitors and is known to have tumor-suppressor function in breast and prostate cancers, acting at the level of tumor invasion and metastasis. However, there have been no published data regarding the role of Maspin in squamous cell carcinoma (SCC) and transitional cell carcinoma (TCC) of urinary bladder. Patients and Methods: We have evaluated the immunohistochemical expression of Maspin and p53 in a series of 134 bladder cancer patients (56 SCC and 78 TCC) and the interrelationship between Clinico pathological features and Maspin and p53 expression. Results: There was positive Maspin expression in 53.7% in all cases. In TCC, expression was found in 48/78 cases (61.5%). High Maspin expression was found in low grade (p<0.001) and advanced stage (p=0.02). In SCC, expression was found in 24/56 (42.8%). There was a statistically significant association between lost Maspin expression and grading (p=0.001). No correlation was found between Maspin expression and other Clinico pathological parameters including gender, clinical stage and Bilharzial infestation. These results indicated that Maspin expression might predict a better prognosis for bladder carcinoma. Also Maspin probably could play a role in tumor progression. p53 was positive in 70 cases (52.2%) of all patients evaluated. In TCC, it was positive in 36/78 cases (46.1%) and correlated with high grade (p=0.01) and advanced stage (p=0.01). In SCC, it was positive in 34/56 cases (60.7%). There was a statistically significant association between p53 expression and high grade (p=0.01) and advanced stage (p=0.01). There was an inverse correlation between the Maspin and p53 expression in TCC and SCC of bladder cancer. We found no significant association between both Maspin and p53 expression and bilharziasis in TCC and SCC; this indicated that Maspin and p53 expression could be prognostic factors in both bilharzial and non

  3. Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

    Directory of Open Access Journals (Sweden)

    Tsang Percy CK

    2006-08-01

    Full Text Available Abstract Background Epigenetic gene silencing is one of the major causes of carcinogenesis. Its widespread occurrence in cancer genome could inactivate many cellular pathways including DNA repair, cell cycle control, apoptosis, cell adherence, and detoxification. The abnormal promoter methylation might be a potential molecular marker for cancer management. Methods For rapid identification of potential targets for aberrant methylation in gynecological cancers, methylation status of the CpG islands of 34 genes was determined using pooled DNA approach and methylation-specific PCR. Pooled DNA mixture from each cancer type (50 cervical cancers, 50 endometrial cancers and 50 ovarian cancers was made to form three test samples. The corresponding normal DNA from the patients of each cancer type was also pooled to form the other three control samples. Methylated alleles detected in tumors, but not in normal controls, were indicative of aberrant methylation in tumors. Having identified potential markers, frequencies of methylation were further analyzed in individual samples. Markers identified are used to correlate with clinico-pathological data of tumors using χ2 or Fisher's exact test. Results APC and p16 were hypermethylated across the three cancers. MINT31 and PTEN were hypermethylated in cervical and ovarian cancers. Specific methylation was found in cervical cancer (including CDH1, DAPK, MGMT and MINT2, endometrial cancer (CASP8, CDH13, hMLH1 and p73, and ovarian cancer (BRCA1, p14, p15, RIZ1 and TMS1. The frequencies of occurrence of hypermethylation in 4 candidate genes in individual samples of each cancer type (DAPK, MGMT, p16 and PTEN in 127 cervical cancers; APC, CDH13, hMLH1 and p16 in 60 endometrial cancers; and BRCA1, p14, p16 and PTEN in 49 ovarian cancers were examined for further confirmation. Incidence varied among different genes and in different cancer types ranging from the lowest 8.2% (PTEN in ovarian cancer to the highest 56

  4. Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

    International Nuclear Information System (INIS)

    Yang, Hui-Juan; Liu, Vincent WS; Wang, Yue; Tsang, Percy CK; Ngan, Hextan YS

    2006-01-01

    Epigenetic gene silencing is one of the major causes of carcinogenesis. Its widespread occurrence in cancer genome could inactivate many cellular pathways including DNA repair, cell cycle control, apoptosis, cell adherence, and detoxification. The abnormal promoter methylation might be a potential molecular marker for cancer management. For rapid identification of potential targets for aberrant methylation in gynecological cancers, methylation status of the CpG islands of 34 genes was determined using pooled DNA approach and methylation-specific PCR. Pooled DNA mixture from each cancer type (50 cervical cancers, 50 endometrial cancers and 50 ovarian cancers) was made to form three test samples. The corresponding normal DNA from the patients of each cancer type was also pooled to form the other three control samples. Methylated alleles detected in tumors, but not in normal controls, were indicative of aberrant methylation in tumors. Having identified potential markers, frequencies of methylation were further analyzed in individual samples. Markers identified are used to correlate with clinico-pathological data of tumors using χ 2 or Fisher's exact test. APC and p16 were hypermethylated across the three cancers. MINT31 and PTEN were hypermethylated in cervical and ovarian cancers. Specific methylation was found in cervical cancer (including CDH1, DAPK, MGMT and MINT2), endometrial cancer (CASP8, CDH13, hMLH1 and p73), and ovarian cancer (BRCA1, p14, p15, RIZ1 and TMS1). The frequencies of occurrence of hypermethylation in 4 candidate genes in individual samples of each cancer type (DAPK, MGMT, p16 and PTEN in 127 cervical cancers; APC, CDH13, hMLH1 and p16 in 60 endometrial cancers; and BRCA1, p14, p16 and PTEN in 49 ovarian cancers) were examined for further confirmation. Incidence varied among different genes and in different cancer types ranging from the lowest 8.2% (PTEN in ovarian cancer) to the highest 56.7% (DAPK in cervical cancer). Aberrant methylation

  5. Primary melanoma lung purposely clinico pathologic considerations of a clinical case

    International Nuclear Information System (INIS)

    Rodríguez, R.; Roldán, G.; Sosa, A.; Mañana, G.; Rodríguez, A.; Panuncio, A.

    2004-01-01

    Introduction: There are few reports of primary malignant melanomas (M M) of visceral organs, general case of metastatic cutaneous and ocular M M regression suffering go unnoticed or diagnosis. Cases of lung primary melanomas (MPP) that meet the clinico pathologic to be considered as such criteria constitute about 0.01% lung tumors and are published as individual case analysis is impossible series of patients. These criteria are under constant review, constituting a field permanent controversial.Materials and method: A case review of the clinical literature on the most relevant of MPP clinico pathological aspects is performed. Case: This is a patient (Pt), 58 years old, smoker, who consults for elements progressive intracranial hypertension installation without other symptoms to note. the Computed tomography (CT) of the skull shows an expansive process only right temporal. Radiography and CT of the chest then show a right parahiliar single nodule without liver involvement without mediastinal symphadenopathy. Flexible bronchoscopy and bronchial brushing are negative. With the proposition that it is a bearer of a lung carcinoma with second only symptomatic brain macroscopically complete resection is performed head injury. The pathology reports that metastasis is a M M. Is discarded the presence of other injuries, especially to skin and eye. Receive brain radiotherapy and a right lower lobectomy whose analysis confirms that this is a M M is performed and that no there are other lesions in the resected lobe. Analyzed the cost / benefit profile indication treatment (t to) with systemic disease in the absence of other obvious injuries continues regular clinical exams. Remained asymptomatic for 5 months relapsing to brain level no new lesions in the lungs. The p te refuses to receive palliative systemic t to reaching, to the presentation of this work, a survival of 11 months. Discussion: Within the clinical criteria that state that is an MPP, the absence of a history of

  6. Basal Cell Epithelioma (A Clinico-pathological Study of 172 Cases

    Directory of Open Access Journals (Sweden)

    R L Solanki

    1989-01-01

    Full Text Available The present paper deals with a clinico-pathological analysis of 172 cases of basal cell epithelioma representing 28% of the total skin cancer case. 1.44% of the total malignant tumours, 1% of the total tumours and 0.24% of the hospital admissions. M:F ratio was 1.26:1. The mean age was 54.06 years with the maximum number of cases in the fifth decade., Most (94% of the lesions were seen on the head and neck region. Histopathologically it showed solid (60.5%, adenoid cystic (15,7%, keratotic (9.3%, pigmented (6.4%, basi-squamous (3.5% and morphoea patterns (2.3%. Perineural lymphatic invasion was seen in 52% of the adenoid cystic basal call epithelioma. Amyloid (12.8% and amyloid like deposits (29.65% were seen in 42% of the case. Amyloid deposits were seen as lichen amyloidosis in 10.46% cases and in or around the tumour cell masses in 16.8% cases. It appeared as structureless homogeneous eosinophilic material and showed congophilia with apple green birefringence on polarising microscopy. It was found to be KMN04 sensitive (AA type protein- secondary amyloidosis. Amyloid like deposits appeared as less homogeneous,, basophilic, fractured material which showed non-specific congophilia with apple- green birefringence and stained with acid orcein stain indicating degenerated collagen (elastoid-degeneration.

  7. Clinico-allergological pattern of allergic contact dermatitis among 70 Indian children

    Directory of Open Access Journals (Sweden)

    Sarma Nilendu

    2010-01-01

    Full Text Available Background: Rapid urbanization, westernization of lifestyles, poor quality of objects available and extremely relaxed vigilance on adherence to ′product safety guidelines′ make any developing country like India highly susceptible to allergic contact dermatitis (ACD even in children. There has been no previous attempts to assess the magnitude of childhood ACD in India. Aims: To assess the clinico-allergological profile of ACD in Indian children. Methods: All consecutive children up to 15 completed years of age who were patch tested over the last 3 years were analyzed from the records. Results: A total of 70 children were studied (average age of disease onset 8.39±3.59 years [SD], range 1-15 years and average age of presentation 10.8 ± 2.99 years [SD], range 5-15 years. Relevant allergy was noted in 48.6% of the patients. Age and sex had no significant role on the prevalence of ACD. Common allergens were paraben (43%, potassium dichromate (27% and fragrance mix (26%. Most relevant allergens were potassium dichromate, paraben and fragrance. Foot was the most commonly involved site (25.7% of patients. Atopy was present in 18 patients (25.7%. A total of 22 irritant reactions were noted in 13 patients. Conclusion: This study reflects the current status of childhood ACD of this region.

  8. Bilirubin-Induced Neurological Dysfunction: A Clinico-Radiological-Neurophysiological Correlation in 30 Consecutive Children.

    Science.gov (United States)

    van Toorn, Ronald; Brink, Philip; Smith, Johan; Ackermann, Christelle; Solomons, Regan

    2016-12-01

    The clinical expression of bilirubin-induced neurological dysfunction varies according to severity and location of the disease. Definitions have been proposed to describe different bilirubin-induced neurological dysfunction subtypes. Our objective was to describe the severity and clinico-radiological-neurophysiological correlation in 30 consecutive children with bilirubin-induced neurological dysfunction seen over a period of 5 years. Thirty children exposed to acute neonatal bilirubin encephalopathy were included in the study. The mean peak total serum bilirubin level was 625 μmol/L (range 480-900 μmol/L). Acoustic brainstem responses were abnormal in 73% (n = 22). Pallidal hyperintensity was observed on magnetic resonance imaging in 20 children. Peak total serum bilirubin levels correlated with motor severity (P = .03). Children with severe motor impairment were likely to manifest severe auditory neuropathy (P bilirubin-induced neurological dysfunction subtype, and the majority of children had abnormal acoustic brainstem responses and magnetic resonance imaging. © The Author(s) 2016.

  9. Ten-year clinico-statistical study of oral squamous cell carcinoma

    International Nuclear Information System (INIS)

    Aoki, Shinjiro; Kawabe, Ryoichi; Chikumaru, Hiroshi; Saito, Tomokatsu; Hirota, Makoto; Miyake, Tetsumi; Omura, Susumu; Fujita, Kiyohide

    2003-01-01

    This clinico-statistical study includes 232 cases of oral squamous cell carcinoma that underwent radical treatment in the Department of Oral and Maxillofacial Surgery, Yokohama City University Hospital, during the decade from 1991 to 2000. Surgery was principally adopted as the first line for treatment in 199 cases, and radiotherapy in 33 cases. The 5-year overall survival rate was 73.4%. The results according to stage were as follows: stage I, 87.5%; Stage II, 77.9%; Stage III, 63.5%; and Stage IV A, 44.7%. The primary sites were classified as follows: upper gingiva, 85.2%; tongue, 73.7%; floor of mouth, 68.9%; lower gingiva, 66.3%; buccal mucosa, 63.9%; and hard palate, 50%. For tongue cancer, the 5-year overall survival rates by stage were: Stage I, 90.8%; Stage II, 82.1%; Stage III, 40.3%; and Stage IV A, 45.7%. Statistical significance was seen between cases of Stages I and II and those of Stages III and IV A stage. For lower gingival cancer, the 5-year overall survival rates by stage were: Stage I, 90.8%; Stage II, 82.1%; Stage III, 40.3%; and Stage IV A, 45.7%. Even in Stage I lower gingival cancers had unfavorable clinical outcomes. Preventive neck dissections were performed on 52 N 0 neck patients, but clinically negative nodes however showed metastasis in 14 patients (26.9%). (author)

  10. Epidemiology and clinico-investigative study of organisms causing vaginal discharge

    Science.gov (United States)

    Venugopal, Swetha; Gopalan, Kannan; Devi, Asha; Kavitha, A.

    2017-01-01

    Background: Abnormal vaginal discharge is a common clinical problem in reproductive age group. It is the second most common problem after abnormal uterine bleeding. It is a neglected health problem, most commonly caused due to vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis (BV). Objectives: The present study was conducted to determine the prevalence of common organisms causing vaginal discharge and also to know the variety of clinical presentation. Materials and Methods: A cross-sectional descriptive study was conducted in the Skin and STD Outpatient Department of Vinayaka Mission Kirupananda Variyar Medical College Hospital, Salem, who presented with abnormal vaginal discharge between September 2012 and September 2014. A total of 100 women in the reproductive age group who had symptoms of vaginitis were examined. Data were coded and analyzed. Results: Out of the 100 patients examined, 77 (77%) cases were organism positive. Among the positive cases, BV (27%) was the most common microbiological cause of abnormal vaginal discharge, followed by trichomoniasis (25%), vaginal candidiasis (22%), combined infection (Candida and BV) (3%), and nonspecific cases (23%). Conclusion: Out of 100 cases, few cases showed discordance between clinical and laboratory diagnosis. This discordance can be due to pitfalls in identifying the causative agent clinically or obscuring of the findings due to improper treatment received for other ailments. Thus, clinico-investigative correlation is more important than other clinical findings alone. PMID:28442807

  11. Clinico-radiological study of fibro-osseous lesions of the jaw

    International Nuclear Information System (INIS)

    Nah, Kyung Sik; Park, Tae Won

    1982-01-01

    Since the fibro-osseous lesion is not a specific diagnostic term, the author studied clinically and radiologically 44 cases which had been diagnosed as fibro-osseous lesion in SNUDH (1972-1981.12). The obtained results were as follows. 1. Clinico-radiologically, the cases of fibro-osseous lesions were divided into two groups. 2. The first group was fibrous dysplasia(21 cases). 3. The second group was tumors of periodontal ligament origin, including ossifying fibroma, cementifying fibroma and cemento-ossifying fibroma (23 cases). 4. In most cases the chief complaint was painless swelling of the jaw and the mean age of the fibrous dysplasia (24.6 yrs) was a little younger than that of the periodontal ligament origin lesions (29.2 yrs). 5. In fibrous dysplasia, maxilla was often involved and showed ground-glass of smoke pattern radiologically. 6. The tumors of periodontal ligament origin occurred more in female, mandible and radiologically showed varying amounts of radiopaque foci in well-circumscribed osteolytic lesion.

  12. A template for a clinico-pathological audit of medical liver biopsies.

    Science.gov (United States)

    Colling, Richard; Fryer, Eve; Cobbold, Jeremy; Collier, Jane; Collantes, Elena; Wang, Lai Mun; Hubscher, Stefan; Wyatt, Judith; Fleming, Kenneth

    2015-11-01

    With changing indications for performing medical liver biopsies, we aimed to develop a tool to allow pathologists to evaluate the current usefulness, value and impact of their medical liver biopsy service. We designed and piloted a questionnaire-based clinico-pathological audit for medical liver biopsies. The audit tool was simple to implement and provided useful information about our service. Hepatologists felt that 96% of reports were clinically useful. 56% of biopsies confirmed clinical diagnoses, 46% helped differentiate between diagnoses and 42% were able to exclude possible diagnoses. 74% resulted in a change of management and 27% of liver biopsies resulted in a diagnosis which was not clinically suspected. We demonstrate the usefulness of an audit tool in providing evidence of the value of the liver pathology service in a large UK regional centre. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  13. Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings.

    Science.gov (United States)

    Mizukami, Keijiro; Shoubudani, Tomoaki; Nishimoto, Seira; Kawamura, Ryuta; Yabuki, Akira; Yamato, Osamu

    2012-06-01

    Trapped neutrophil syndrome (TNS) is an autosomal recessive inherited neutropenia known in Border Collies since the 1990's. Recently, the causative mutation has been identified in the canine VPS13B gene and a DNA-based diagnosis has now become available. The present paper describes clinical and clinico-pathologic findings in a Border Collie with TNS that was molecularly diagnosed for the first time in Japan. In a 10-week-old male Border Collie with microgenesis and symptoms related to recurrent infections, a hematological examination revealed severe leukopenia due to neutropenia, suggesting the dog to be affected by inherited neutropenic immunodeficiency. Direct DNA sequencing demonstrated that the dog was homozygous for the causative mutation of TNS and both its parents were heterozygous carriers. In addition, a simple and rapid polymerase chain reaction-based length polymorphism analysis coupled with microchip electrophoresis was developed for the genotyping of TNS. This assay could discriminate clearly all genotypes, suggesting that it was suitable for both individual diagnosis and large-scale surveys for prevention.

  14. Pulmonary sporotrichosis: case series and systematic analysis of literature on clinico-radiological patterns and management outcomes.

    Science.gov (United States)

    Aung, Ar Kar; Teh, Bing Mei; McGrath, Christopher; Thompson, Philip J

    2013-07-01

    Pulmonary infections by Sporothrix spp. manifest radiologically as cavitary or non-cavitary disease depending on whether the infection is primary pulmonary or multifocal sporotrichosis. Despite current guidelines, the optimal management for pulmonary sporotrichosis remains unclear. In order to clarify this, we present two cases of pulmonary sporotrichosis, as well as the results of a comprehensive literature review of treatment outcomes based on clinico-radiological presentation patterns of the disease. A literature search of all case reports in English language over the last 50 years (1960-2010) was conducted. Data on patient characteristics, risk factors, clinico-radiological patterns, treatment modalities and outcomes were collected and analyzed. A total of 86 cases were identified, i.e., 64 (74.4%) primary pulmonary and 22 (25.6%) multifocal sporotrichosis. Radiologically, primary pulmonary disease was commonly characterized by cavity formation which was lacking in multifocal infections (P = 0.0001). Immunosuppressant use was more common in multifocal sporotrichosis (P = 0.0001), while hemoptysis was more common in primary pulmonary form (P = 0.01). No other differences in patient characteristics or risk factors were noted. Extra-pulmonary multifocal sporotrichosis most commonly involved skin (81.8%) and joints (45.4%). For patients with cavitary primary pulmonary sporotrichosis, outcomes from medical therapy alone were inferior to surgical intervention (P = 0.02). However, for both primary pulmonary and multifocal sporotrichosis with non-cavitary disease, medical therapy alone provided good outcomes. Only 12 (16.7%) cases were treated with itraconazole. Treatment of pulmonary sporotrichosis should be guided by the clinico-radiological patterns of presentation. Medical therapy alone is likely sufficient for non-cavitary disease while early surgery should be considered for cavitary primary pulmonary sporotrichosis. The experience in treating cavitary disease

  15. Thyroiditis: a Clinico-cytomorphological Study with a Reference to the Ethnic Groups of Northeast Regions of India.

    Science.gov (United States)

    Kalita, Abhijit; Baruah, Ronica

    2015-12-01

    Definite clinico-cytological criterion is outlined for thyroid lesions. Fine needle aspiration cytology (FNAC) makes it easier to segregate cases of thyroiditis (Chronic lymphocytic thyroiditis/Hashimoto's thyroiditis-CLT/HT, and subacute thyroiditis-SAT) from other benign and malignant lesions of thyroid. The study was done for a period of 5½ years at a diagnostic centre in Guwahati. Patients underwent FNAC and smears were studied for cytomorphology. A correlation with clinical features and thyroid function, including antithyroid antibody estimation, was done, wherever possible. 792 thyroid lesions were encountered during the study, of which 213 (26.89 %) were cases of thyroiditis (70.43 % CLT/HT, 24.9 % SAT and 3.76 % having overlapping features of CLT/HT and SAT); 2 cases (0.9 %) of CLT showed suspicion of Non-Hodgkin's Lymphoma (NHL), which was confirmed on histopathology. 24 cases (11.26 %) belonged to different ethnic tribal groups of Northeast India. CLT/HT presented predominantly with diffuse thyroid enlargement, but 12 cases (8 % of CLT/HT cases) had nodular enlargement. Patients presented with predominantly hypothyroidism; however occasional hyperthyroid cases were also seen. SAT showed signs of inflammation and presented with hyperthyroidism. Overlap cases of CLT/HT and SAT showed combined clinico-cytomorphological features of both lesions. 37.5 % cases with overlapping features belonged to tribal communities. A rise in incidence of thyroiditis, particularly CLT/HT, was seen. Overlap features of CLT/HT and SAT was noticed in significant percentage. No bias was noticed amongst any specific tribal community. FNAC, coupled with clinico-serological study, helps to diagnose thyroiditis at early stage.

  16. Clinico-pathological study to evaluate oral lichen planus for the establishment of clinical and histopathological diagnostic criteria.

    Science.gov (United States)

    Hiremath, Santhosh; Kale, Alka D; Hallikerimath, Seema

    2015-01-01

    Lichen planus and lichenoid lesions affecting the oral cavity show similar clinico-pathological features creating a diagnostic dilemma. Hence, the aim of the present study was to establish a clinical and histopathological correlation in the diagnosis of oral lichen planus, based on the modified WHO diagnostic criteria of oral lichen planus and oral lichenoid lesions proposed by Van der Meij and Van der Waal in 2003. In the present study, 100 cases of oral lichen planus were clinically and histopathologically analyzed. Out of the 100 cases, 50 were prospective and 50 were retrospective cases. Prospective cases were collected based on the clinical diagnosis of oral lichen planus and oral lichenoid lesion. Retrospective cases were collected based on the histopathological diagnosis of oral lichen planus. Both the clinical and histopathological analyses were performed based on a proposal for a set of modified diagnostic criteria of oral lichen planus and oral lichenoid lesion. A final diagnosis of oral lichen planus was made only after the correlation of the clinical diagnosis with the histopathological diagnosis. The interobserver agreement among three observers for both prospective and retrospective cases in the final diagnosis of oral lichen planus was found to be "good" to "very good" indicating high reproducibility. However, the final diagnoses of true oral lichen planus after clinico-pathological correlation in prospective and retrospective study groups appeared to be 38.0% and 54.0% respectively. The results of the present study revealed mild to moderate clinico-pathological correlation in the final diagnosis of oral lichen planus for the prospective and retrospective study groups respectively.

  17. Occipito-atlanto-axial osteoarthritis: a cross sectional clinico-radiological prevalence study in high risk and general population.

    Science.gov (United States)

    Badve, Siddharth A; Bhojraj, Shekhar; Nene, Abhay; Raut, Abhijit; Ramakanthan, Ravi

    2010-02-15

    A cross-sectional clinico-radiologic evaluation of occipito-atlantoaxial (OC1C2) region of 2 population groups. Determine the prevalence of OC1C2 osteoarthritis in porters involved in carrying loads on the head and general male population. Describe its clinico-radiologic manifestations. In addition to age, head loading is a known cause of degeneration affecting the occipito-cervical region. The impact of head loading in the population aged between third and sixth decade is unknown. Head loading is a common custom in the developing countries. Study group (n = 107) included randomly selected male porters from railway stations who underwent computed tomography (CT) study of the OC1C2 region, plain radiographs of the cervical spine and detailed clinical examination. Control group (n = 107) included randomly selected male patients undergoing CT scan study for diseases of paranasal sinuses with coincidental screening of OC1C2 region along with clinical assessment. The data were analyzed using SPSS 15 software. Mean age for study group was 32.6 years and controls was 34.6 years (P = 0.156). In the study group, duration of occupational exposure was 10.9 (+/-8.7) years; 81.3% porters being symptomatic with an age of 33.4 (+/-9.6) years. Radiologic prevalence of OC1C2 osteoarthritis in study group was 91.6% and in control group was 6.8%; age of affected individuals was 33.4 (+/-9.3) and 47.9 (+/-8.0) years, respectively. Most common complaint was suboccipital neck pain (69.7%); while the CT finding was decreased joint space with sclerosis and irregularity of the margins (81.3%). No statistically significant association was found between presence of radiologic changes and symptoms. Age, duration of occupational exposure and its relationship with various clinico-radiologic manifestations was studied. This condition has significant prevalence in porters, beginning at an early age. Diagnosis is based on the clinico-radiologic presentation. CT is the investigation of choice

  18. Clinico-serologic co-relation in bi-directional ABO incompatible hemopoietic stem cell transplantation

    Directory of Open Access Journals (Sweden)

    Sabita Basu

    2015-01-01

    Full Text Available Background: The ABO blood group system is of prime significance in red cell transfusion and organ transplantation. However, ABO compatibility is not critical in allogenic hemopoietic stem cell transplantation (HSCT and approximately 40-50% of hemopoietic stem cell transplants are ABO incompatible. This incompatibility may be major, minor or bi-directional. Though there are descriptions of transfusion practice and protocols in ABO incompatible HSCT, there are considerable variations and transfusion support in these patients can be very challenging. Aims: The immunohematologic observations in two cases of bi-directional ABO incompatible HSCT have been described, and clinico-serologic correlation has been attempted. Materials and Methods: In both cases, peripheral blood stem cell harvests were obtained using the Cobe spectra cell separator. Immunohematologic assessments in the donor and recipient were done as a part of pre HSCT evaluation. Both the standard tube technique and column agglutination method (Ortho Biovue Micro Bead System was used. Antibody screen was done by column agglutination method using three cell panel (Surgiscreen cells. Isoagglutinin titration was done by the master dilution method and standard validated techniques were used. Results: The pattern of laboratory findings in the two cases was different and so were the clinical outcomes. Although there was early engraftment in the first case, the second case developed pure red cell aplasia and this was well-reflected in the immunohematologic assessments. Conclusion: Immunohematologic assessment correlated well with the clinical picture and could be used to predict clinical outcome and onset of complications in ABO incompatible HSCT.

  19. Hemato-biochemical and clinico-epidemiological aspects of parturient hemoglobinuria in Nili-Ravi buffaloes

    Directory of Open Access Journals (Sweden)

    A. Khan

    2010-02-01

    Full Text Available For this study, 60 buffaloes suffering from parturient hemoglobinuria (PHU were randomly selected from field cases occurring in three districts of Punjab, Pakistan and simultaneously, 60 clinically healthy buffaloes of similar description from the same localities were included for case control study. Clinico-epidemiological data were collected. Blood/serum samples from all buffaloes were collected and analyzed. The most prominent clinical sign was passing of red to coffee colored urine. Milk production was reduced and respiration and pulse rates were significantly accelerated. Ruminal motility was significantly weak and reduced along with characteristic straining while defecating. The case fatality was 15%. A significantly high occurrence of PHU was observed in the winter season (41.8%. Maximum number of affected buffaloes (25.0% was in 4th lactation. Twenty-seven (45.0% buffaloes developed hemoglobinuria in the post calving period and majority (59.3% of these were within 1-23 days of calving. Of the 33 (55.0% PHU affected pregnant buffaloes, 18 (54.6% were in their third trimester. The highest cases of PHU were observed in buffaloes producing 10 or more liters of milk/day (42.5%. Recurrence of PHU was observed in 18.3% buffaloes. Mean values of total erythrocyte counts, hemoglobin concentration and packed cell volume were lower (P<0.001, while erythrocyte sediment rate was higher (P<0.001 in PHU affected buffaloes as compared to the values in healthy buffaloes. Neutrophils were significantly higher, while lymphocytes and erythrocytic glucose-6-phosphate dehydrogenase (G6PD were lower, in PHU affected buffaloes than in healthy buffaloes. Serum phosphorus, copper and selenium were significantly (P<0.001 lower, whereas potassium, iron and molybdenum (P<0.001 were higher in buffaloes suffering from PHU than healthy buffaloes.

  20. Medication adherence among Nigerians with schizophrenia: correlation between clinico-demographic factors and quality of life

    Directory of Open Access Journals (Sweden)

    Oluseun P. Ogunnubi

    2017-03-01

    Full Text Available Medication adherence contributes significantly to symptom remission, recovery and wellbeing in mental illnesses. We evaluated how medication adherence correlates with clinico-demographic factors and quality of life (QoL in a sample of Nigerians with schizophrenia. This descriptive crosssectional study involved 160 randomly selected participants with confirmed diagnosis of schizophrenia based on MINI International Neuropsychiatric Interview. Data on socio-demographic and clinical characteristics of participants were collected with a questionnaire. Medication adherence was assessed with Morisky Medication Adherence Questionnaire, and participants completed the World Health Organization Quality of Life Scale-BREF. The mean age of participants was 38.54 (±11.30 years, and all the participants were on antipsychotics, but only 45% were adherent to their medication. Out of all the participants, 45 (28.2% considered their overall QoL to be good, 97 (60.6% considered theirs to be fair, while 18 (11.2% reported poor QoL. Medication non-adherence correlated negatively with good QoL across multiple dimensions including overall QoL (r=- 0.175, health satisfaction (r=-0.161, physical (r=-0.186 and psychological domain (r=-0.175. Again, participant’s age (r=- 0.190 and age of onset of illness (r=-0.172 correlated negatively with medication nonadherence, and a trend towards relapse delay with medication adherence was also observed (r=-0.155. The effect size of these correlations were however small. Our findings suggest a link between medication adherence and QoL in schizophrenia, such that strategy that addresses medication nonadherence and its determinants may have potential benefits on wellbeing. Further hypotheses-driven studies are desirable.

  1. Lymphatic Vessel Density as Prognostic Factor in Breast Carcinoma: Relation to Clinico pathologic Parameters

    International Nuclear Information System (INIS)

    El-Gendi, S.; Abdel-Hadi, M.

    2009-01-01

    Angiogenesis and lymphangiogenesis are essential for breast cancer growth and progression. This study aimed at investigating lymphatic micro vessel density (LVD) and microvessel density (MVD) as prognostic markers in breast carcinoma. Forty breast carcinomas were immuno stained for D2-40, CD31 and VEGF. Median lymphatic and blood micro vessel densities, as well as VEGF expression, were related to each other and to clinico pathologic parameters including lymph node (Ln) status. The efficacy of haematoxylin and eosin (H and E) in detecting lymphatic vessel invasion (LVI) compared to D2-40 immunostaining was also investigated. D2-40 stained normal lymphatic endothelium and myoepithelial cells, but with different staining patterns. D2-40 LVD related significantly to CD31 counts (r=0.470; p=0.002), and LN metastasis (Mann-Whitney U=101.500; p=0.043); however, it did not relate to age, tumor grade, tumor size or LVI. D2-40 identified LVI in 3 more cases (7.5%) than those detected by H and E. VEGF was expressed in 85% of cases, and was significantly related to CD31 and D2-40 counts (p=0.033 and 0.007, respectively). In conclusion, D2-40 LVD showed a significant association with LN metastasis, and can be considered to segregate patients with positive from those with negative LNs. D2-40 enhances the detection of LVI relative to H and E staining reflecting a potential for lymphatic metastatic spread and possible poor prognosis

  2. [Clinico-epidemiological characteristics of HIV-positive immigrants: study of 371 cases].

    Science.gov (United States)

    Llenas-García, Jara; Rubio, Rafael; Hernando, Asunción; Fiorante, Silvana; Maseda, Diego; Matarranz, Mariano; Costa, José Ramón; Alonso, Beatriz; Pulido, Federico

    2012-10-01

    The number of HIV-positive immigrants have increased in Spain in the last few years, and now represent a significant proportion of the epidemic. Our objective is to describe the clinico-epidemiological characteristics of HIV-positive immigrants seen in a specialist unit in Madrid. Retrospective study. Every patient born in a country other than Spain and attended an HIV Unit in Madrid between 1992 and 2009 was included. Of the 371 patients included, 53.1% were Latin Americans, 24.5% Sub-Saharan Africans, and 22.4% others), and 60% were males. Immigrants represented 0.3% of new patients in 1992 and rose to 49.2% in 2009. The principal reason for HIV testing had been pregnancy/delivery among women (32.7%) and having a category-B disease among men (17.4%). Sexual transmission accounted for 92% of patients. Tuberculosis was the principal AIDS-diagnosing illness. Respectively 90%, 7.7%, 60%, 26.7%, 96% and 95% of patients had an IgG for HAV, HCV, Toxoplasma, Treponema, CMV and VZV. VHB-Ags+: 5.4%; PPD+: 17%. At least one syphilis episode was recorded in 62% of the men who have sex with men (MSM). Prevalence of HLA-B5701 was 6%, 0.9% and 3.8% in Caucasians, Amerindians and Afro-Americans, respectively. Immigrants represent a significant proportion of new HIV-positive patients. It is a very heterogeneous group according to their clinical and epidemiological characteristics. Copyright © 2011 Elsevier España, S.L. All rights reserved.

  3. Immunohistochemical Expression of Survivin in Breast Carcinoma: Relationship with Clinico pathological Parameters, Proliferation and Molecular Classification

    International Nuclear Information System (INIS)

    YOUSSEF, N.S.; HEWEDI, I.H.; ABD RABOH, N.M.

    2008-01-01

    Background and Objective: Survivin is a novel member of the inhibitor of apoptosis (IAP) gene family. It is associated with more aggressive behavior and parameters of poor prognosis in most human cancers including gastric, colorectal and bladder carcinomas. However, conflicting data exist on its prognostic effect in breast cancer. This current study is designed to assess survivin expression in breast carcinoma relating results with clinico pathological parameters, proliferation (MIB-1) and molecular classification. Material and Methods: Our retrospective study com- prised of 65 archived cases of breast carcinoma. Samples from the tumor and the adjacent normal breast tissue were immuno stained for survivin and MIB-1. Nuclear and cytoplasmic survivin expression was evaluated in normal breast tissue and carcinoma regarding both the intensity and the percentage of positive cells. ER, PR, HER2 were used as surrogate markers to classify the cases into four molecular subtypes. Results: Survivin expression was detected in 78.5% of breast carcinomas. The adjacent normal breast tissue was immuno negative. Survivin expression showed significant association with increased tumor size ( p <0.0001), high histologic grade ( p =0.04), lymph node metastases ( p <0.001), advanced tumor stage ( p <0.0001), MIB-1 expression ( p =0.02), negative estrogen receptor status ( p =0.01) and negative progesterone receptor status ( p <0.0001). The subcellular localization of survivin significantly related to histologic grade, stage and lymph node involvement. The percentage of TNP (triple negative phenotype) and HER2+/ER-PR- tumors expressing survivin were significantly higher compared to the Luminal subtypes ( p =0.01). Conclusion: Survivin expression was associated with parameters of poor prognosis in breast cancer. Moreover, the cancer-specific expression of survivin, coupled with its importance in inhibiting cell death and in regulating cell division, makes it a potential target for novel

  4. [Clinico-pathological features of papillary thyroid cancer coexistent with Hashimoto's thyroiditis].

    Science.gov (United States)

    Molnár, Sarolta; Győry, Ferenc; Nagy, Endre; Méhes, Gábor; Molnár, Csaba

    2017-02-01

    Former studies suggest the frequent coexistence of Hashimoto's thyreoditis with papillary thyroid cancer, frequently featured by multifocal carcinogenesis but lower clinical stages compared to thyroid cancers lacking thyroiditis. We examined the clinico-pathological correlations between Hashimoto's thyroditis and papillary thyroid cancer in our region in the North-Eastern part of Hungary. We included a total of 230 patients with papillary thyroid cancer who underwent thyroid surgery at the Surgical Department of the University of Debrecen. Patients' sex, age, multifocality of thyroid cancer and clinical stage were evaluated. Cases included 40 patients (17.4%) with (4 male, 36 female) and 190 (82.6%) patients without HT (44 male, 146 female). Hashimoto's thyroiditis related thyroid cancer was almost exclusively associated with the papillary histological type. Multifocality of papillary cancer was significantly more frequent with coexisting Hashimoto's thyroiditis (16/40; 40.0%) compared to cases uninvolved (45/190; 23.7%; p = 0.034). In contrast, lymph node metastasis was significantly less frequent among patients with Hashimoto's thyroiditis (4 pN1 [36.4%]; 7 pN0 [63.6%]) then without it (34 pN1 [82.9%]; 7 pN0 [17.1%]; p = 0.002). Higher frequency and multifocality of papillary thyroid cancer might be the consequence of preexisting Hashimoto's thyroiditis to be considered as a preneoplastic stimulus supporting carcinogenesis, though the exact pathomechanism of this correlation is not clear yet. Orv. Hetil., 2017, 158(5), 178-182.

  5. Clinico-pathological profile in the infants and children in dengue 2012 epidemic, Kolkata

    Directory of Open Access Journals (Sweden)

    Saha K Ashis, Ghosh Shibendu

    2014-03-01

    Full Text Available Background: Dengue fever (DF is responsible for cyclical and frequent epidemic in different parts of India in its varieties of presentations. In 1992 large number of children died of Dengue hemorrhagic fever (DHF. Aims and objective: In this study, we evaluated the demography and clinico-pathological profile in dengue affected infants and children in 2012 Kolkata epidemic. Materials and methods: Total 233 patients (between 1-18 years, with either Non structural protein 1 antigen or dengue Immunoglobulin positive admitted in our hospital. After taking proper history and physical examination, blood were sent for different hematological and biochemical examinations on the day of admission and after 24-48 hours of admission. We differentiated the dengue patients into DF and DHF based on platelet count. Results: Male female ratio and DF to DHF ratio were 1: 0.86 and 1: 3.5 respectively. Mean age of DF and DHF were 10.31±5.41 years and 12.6±4.51 years respectively. Mean duration of fever in DF and DHF cases were 5.33±1.13 and 6.08±1.79 days respectively. Headache, backache, nausea/vomiting, rash, anorexia, loose motions were statistically significant in DF. In spite of significant positive tourniquet test in DHF patients (76.92%, only 13 patients showed evidence of bleeding. Hematocrit (Hct values between 30-40 and below 30 were significant in DHF and DF patients respectively. Leucopenia and increased liver enzymes (SGOT and SGPT were commonly observed in both DF and DHF patients. Hepatomegaly was observed in 13.72% of DF patients, whereas, isolated hepatomegaly, ascites, combined hepatomegaly with ascites and evidence of pleural effusion were observed in 4.94%, 1.64%, 3.29% and 7.14% of DHF patients respectively. Conclusion: In seropositive DHF patients, fever, headache, backache, loose motions were the predominant symptoms associated with hepatomegaly, elevated liver enzymes and evidence of plasma leakage.

  6. Clinico pathological spectrum of mycosis fungoides type cutaneous t-cell lymphoma

    International Nuclear Information System (INIS)

    Shaikh, Z.I.; Rahman, S.B.

    2006-01-01

    Objective: To determine the clinical, histological, and immuno phenotypic characteristics of mycosis fungoides type cutaneous T-cell lymphoma. Design: Descriptive study. Place and Duration of Study: This study was conducted from January 2000 to December 2004 at the Department of Dermatology, Military Hospital and the Department of Dermatopathology, Armed Forces Institute of Pathology, Rawalpindi. Materials and Methods: The medical case records of patients with mycosis fungoides diagnosed during the period of study were surveyed. Data was collected pertaining to patients' characteristics, clinical descriptions, histopathological features, immuno phenotypic analysis and stage of disease at the time of diagnosis. Results: A total of 33 cases of mycosis fungoides were diagnosed between the years 2000 and 2004. There were 24 male and 9 female patients with male to female ratio of 2.6:1 The age ranged from 24 to 68 years and the duration of disease prior to diagnosis varied between 2 to 36 months. The number of skin biopsies performed for definite diagnosis ranged from 01 to 5. The various clinical presentations recorded in these patients were hypo pigmented patches in 7 (21.3%), infiltrated papules and plaques in 6 (18.2%), erythroderma in 5 (15.2%), psoriasiform lesions in 3 (9%), and nodular lesions in 3 (9%) patients. There were 2 (6%) cases respectively of noduloulcerative, ichthyosiform and poikilodermatous lesions, and 1 (3%) case each of follicular, morphoea-like and purpuric skin lesions. The predominant histological features were lymphocytic infiltrate in the upper dermis, epidermotropism, haloed lymphocytes in epidermis, Pautrier's micro abscesses, and interface dermatitis. The immunohistochemical studies (n=12) showed predominantly T helper cell immuno phenotype (CD3+, CD45RO+) in 11 (92%) cases and T suppressor cell immuno phenotype (CD3+, CD8+) in 1 (8%) patient. Conclusion: The mycosis fungoides type cutaneous T-cell lymphoma has a wide clinico

  7. CLINICO-EPIDEMIOLOGICAL PROFILE OF ORAL CANCER: A HOSPITAL BASED STUDY

    Directory of Open Access Journals (Sweden)

    Kapil H Agrawal

    2012-07-01

    Full Text Available Background: India is heading towards various types of non-communicable diseases, which are also known as modern epidemics. Among these modern epidemics cancer is among the ten commonest cause of mortality in developing countries including India. Oral cancer is a major problem in India and accounts for 50-70% of all the cancers diagnosed. Ninety percent (90% of oral cancers in South East Asia including India are linked to tobacco chewing and tobacco smoking. Research question: What is the profile of Oral cancer (Oral cavity cases reported in the hospital? Objective: To study the clinico-epidemiological profile associated with Oral cancer cases. Methods: Study Design: Hospital based, Cross -sectional study. Settings: Shri Siddhivinayak Ganapati Cancer Hospital, Miraj, Maharashtra. Participants and Sample size: As it is a time bound study sample size comprised of all the confirmed cases of oral cancer reported in the hospital during the study period. The study was carried out from 1st March 2005 to 28th February 2006. Study variables included demographic factors, socioeconomic factors, enquiries regarding modifiable risk factors such as tobacco usage, alcohol consumption, site involved (within oral cavity, staging, histopathological examination, treatment modality used. Data entry and statistical analysis was done using Microsoft excel. Data presented in form of percentages and proportions. Results: Out of the total 160 cases, majority of the subjects were above 40 years age. 36 (22% of subjects were young adults (below 40 years age. 125 (78% subjects were male. Most of the subjects belonged to upper lower and lower middle socio-economic scale according to modified Kuppuswamy classification. It was observed that 139 (87% cases consumed tobacco in all forms. Out of these, ninety cases consumed tobacco in chewable form. Tobacco was chewed mainly in the form of gutka. Only ten (10 female subjects chewed tobacco. No female subjects smoked. The most

  8. Radiation protection; Proteccion Radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Ures Pantazi, M [Universidad de la Republica, Facultad de Quimica (Uruguay)

    1994-12-31

    This work define procedures and controls about ionizing radiations. Between some definitions it found the following topics: radiation dose, risk, biological effects, international radioprotection bodies, workers exposure, accidental exposure, emergencies and radiation protection.

  9. Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations.

    Directory of Open Access Journals (Sweden)

    Nalini Venkatesan

    Full Text Available To correlate the differentially expressed miRNAs with clinico-pathological features in uveal melanoma (UM tumors harbouring chromosomal 3 aberrations among South Asian Indian cohort.Based on chromosomal 3 aberration, UM (n = 86 were grouped into monosomy 3 (M3; n = 51 and disomy 3 (D3; n = 35 by chromogenic in-situ hybridisation (CISH. The clinico-pathological features were recorded. miRNA profiling was performed in formalin fixed paraffin embedded (FFPE UM samples (n = 6 using Agilent, Human miRNA microarray, 8x15KV3 arrays. The association between miRNAs and clinico-pathological features were studied using univariate and multivariate analysis. miRNA-gene targets were predicted using Target-scan and MiRanda database. Significantly dys-regulated miRNAs were validated in FFPE UM (n = 86 and mRNAs were validated in frozen UM (n = 10 by qRT-PCR. Metastasis free-survival and miRNA expressions were analysed by Kaplen-Meier analysis in UM tissues (n = 52.Unsupervised analysis revealed 585 differentially expressed miRNAs while supervised analysis demonstrated 82 miRNAs (FDR; Q = 0.0. Differential expression of 8 miRNAs: miR-214, miR-149*, miR-143, miR-146b, miR-199a, let7b, miR-1238 and miR-134 were studied. Gene target prediction revealed SMAD4, WISP1, HIPK1, HDAC8 and C-KIT as the post-transcriptional regulators of miR-146b, miR-199a, miR-1238 and miR-134. Five miRNAs (miR-214, miR146b, miR-143, miR-199a and miR-134 were found to be differentially expressed in M3/ D3 UM tumors. In UM patients with liver metastasis, miR-149* and miR-134 expressions were strongly correlated.UM can be stratified using miRNAs from FFPE sections. miRNAs predicting liver metastasis and survival have been identified. Mechanistic linkage of de-regulated miRNA/mRNA expressions provide new insights on their role in UM progression and aggressiveness.

  10. Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinico pathological Correlation

    International Nuclear Information System (INIS)

    Tan, K. B.; Tan, S. H.; Lee, Y. S.; Wee Aw, D. C.; Jaffar, H.; Lim, T. C.; Lee, S. J.

    2013-01-01

    Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinisation, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist. Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinico pathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases

  11. Pituitary stalk transection syndrome: Comparison of clinico-radiological features in adults and children with review of literature

    International Nuclear Information System (INIS)

    Kulkarni, Chinmay; Moorthy, Srikanth; Pullara, Sreekumar K; Rajeshkannan, R; Unnikrishnan, Ambika G

    2012-01-01

    Hypo-pituitarism results from impaired production of one or more of anterior pituitary trophic hormones. A rare cause of hypo-pituitarism is pituitary stalk transection syndrome. The MRI features of this condition in children and its association with hormonal deficiencies have been reported earlier. Reports on adults with this disorder are scarce, with only one small case series published in the recent literature. We studied the hormonal deficiency pattern and MRI findings of 12 patients with pituitary stalk transection syndrome who presented to our department between 2004 and 2011. Six patients were children and six were adults (≥18 years). This article compares the adult clinico-radiological phenotype of pituitary transection syndrome with the pediatric group of patients with same condition

  12. Comparison of clinico-radiological features of patients with positive cultures of nontuberculous mycobacteria and patients with tuberculosis

    International Nuclear Information System (INIS)

    Ba-Hammam, Ahmed; Sharif, Yasir; Masood, Mohammad; Isnani, Arthur; Youssef, Ismael; Kambal, Abdelmageed; Shaikh, Shaffi

    2005-01-01

    To identify the clinico-radiological features of patients with positive cultures for nontuberculous mycobacteria (NTM) and compare those to a sample of patients with tuberculosis (MTB). A laboratory database was used to retrieve all specimens submitted to King Khalid University Hospital, Riyadh, mycobacteriology laboratory for mycobacterial smears and cultures during the period from October 1999-April 2002. Using this database, the original records of the mycobacteriology laboratory and a review of the patient's health records, a standard proforma was completed that included demographic, clinical, radiological and laboratory information on patients included in this study. The patients were divided into 2 groups; the NTM group, which included patients with positive cultures for NTM and the MTB group, which included a sample of patients with documented tuberculosis. During the study period, 286 patients had positive mycobacterial cultures. Seventy patients (24.5%) grew NTM and 216 (75.5%) grew MTB. For patients with MTB, 54 patients were included as per the selection protocol of the study. There was no difference between the 2 groups in all measured demographic variables. The presence of weight loss and fever was significantly more in the MTB group. Radiologically, the presence of hilar adenopathy was more significant among patients with MTB than those with NTM (17% versus 4%, p=0.02). However, bronchiectatic changes were seen significantly more among NTM patients compared to patients with MTB (26% versus 11%, p=0.03). The isolation of NTM in the mycobacteriology laboratory is high. The clinico-radiological features were not sufficiently specific to differentiate patients with NTM from patients with MTB. Local studies are needed to explore NTM disease in various developing countries and identify the NTM species causing infections in non-immunosuppressed patients in each locality. (author)

  13. Clinico-laboratory spectrum of dengue viral infection and risk factors associated with dengue hemorrhagic fever: a retrospective study.

    Science.gov (United States)

    Mallhi, Tauqeer Hussain; Khan, Amer Hayat; Adnan, Azreen Syazril; Sarriff, Azmi; Khan, Yusra Habib; Jummaat, Fauziah

    2015-09-30

    The incidence of dengue is rising steadily in Malaysia since the first major outbreak in 1973. Despite aggressive measures taken by the relevant authorities, Malaysia is still facing worsening dengue crisis over the past few years. There is an urgent need to evaluate dengue cases for better understanding of clinic-laboratory spectrum in order to combat this disease. A retrospective analysis of dengue patients admitted to a tertiary care teaching hospital during the period of six years (2008 - 2013) was performed. Patient's demographics, clinical and laboratory findings were recorded via structured data collection form. Patients were categorized into dengue fever (DF) and dengue hemorrhagic fever (DHF). Appropriate statistical methods were used to compare these two groups in order to determine difference in clinico-laboratory characteristics and to identify independent risk factors of DHF. A total 667 dengue patients (30.69 ± 16.13 years; Male: 56.7 %) were reviewed. Typical manifestations of dengue like fever, myalgia, arthralgia, headache, vomiting, abdominal pain and skin rash were observed in more than 40 % patients. DHF was observed in 79 (11.8 %) cases. Skin rash, dehydration, shortness of breath, pleural effusion and thick gall bladder were more significantly (P  40 years (OR: 4.1, P hospitalization (OR: 2.3, P = 0.037) as independent predictors of DHF. Overall mortality was 1.2 % in our study. Current study demonstrated that DF and DHF present significantly different clinico-laboratory profile. Older age, secondary infection, diabetes mellitus, lethargy, thick gallbladder and delayed hospitalization significantly predict DHF. Prior knowledge of expected clinical profile and predictors of DHF/DSS development would provide information to identify individuals at higher risk and on the other hand, give sufficient time to clinicians for reducing dengue related morbidity and mortality.

  14. Advance of the National Program of Radiological Protection and Safety for medical diagnostic with X-rays; Avance del Programa Nacional de Proteccion y Seguridad Radiologica para diagnostico medico con rayos X

    Energy Technology Data Exchange (ETDEWEB)

    Verdejo S, M. [Direccion de Riesgos Radiologicos, Direccion General de Salud Ambiental (Mexico)

    1999-07-01

    The National Program of Radiological Protection and Safety for medical diagnostic with X-ray (Programa Nacional de Proteccion y Seguridad Radiologica para diagnostico medico con rayos X) was initiated in the General Direction of Environmental Health (Direccion General de Salud Ambiental) in 1995. Task coordinated with different dependences of the Public Sector in collaboration between the Secretary of Health (Secretaria de Salud), the National Commission of Nuclear Safety and Safeguards (Comision Nacional de Seguridad Nuclear y Salvaguardias) and, the National Institute of Nuclear Research (Instituto Nacional de Investigaciones Nucleares). The surveillance to the fulfilment of the standardization in matter of Radiological Protection and Safety in the medical diagnostic with X-rays has been obtained for an important advance in the Public sector and it has been arousing interest in the Private sector. (Author)

  15. Clinico-pathological studies on the effects of preoperative hyperthermo-chemo-radiotherapy for advanced esophageal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Tsutomu; Ide, Hiroko; Eguchi, Reiki (Tokyo Women' s Medical Coll. (Japan)) (and others)

    1991-12-01

    We report clinico-pathological studies on the effect of preoperative hyperthermia and chemotherapy combined with radiotherapy (HCR) for progress of the local curability of advanced esophageal carcinoma. The subjects of these studies were 17 patients who underwent subtotal esophagectomy after preoperative irradiation of 40 Gy from 1980 to 1989, of which 8 patients had HCR, 6 patients irradiation only (R), 3 patients both irradiation and chemotherapy (CR). The clinical response rate of the patients with R or CR was 33% (PR 3, MR 3, NC 3), and the histological effective (Ef{sub 3} or Ef{sub 2}) rate was 56% (Ef{sub 3} 1, Ef{sub 2} 4, Ef{sub 1} 4). The clinical response rate of the patients with HCR was 88% (PR 7, MR 1), and the histological effective rate was 100% (Ef{sub 3} 1, Ef{sub 2} 7). HCR was more effective than R or CR for the local lesion of esophageal carcinoma histopathologically (p<0.05). However, the survival rate of patients with HCR was similar to R and CR, respectively. These results suggest that further improvement of the heating methods and the methods of combining hyperthermia with irradiation and chemotherapy is needed. (author).

  16. Clinico-pathological studies on the effects of preoperative hyperthermo-chemo-radiotherapy for advanced esophageal carcinoma

    International Nuclear Information System (INIS)

    Nakamura, Tsutomu; Ide, Hiroko; Eguchi, Reiki

    1991-01-01

    We report clinico-pathological studies on the effect of preoperative hyperthermia and chemotherapy combined with radiotherapy (HCR) for progress of the local curability of advanced esophageal carcinoma. The subjects of these studies were 17 patients who underwent subtotal esophagectomy after preoperative irradiation of 40 Gy from 1980 to 1989, of which 8 patients had HCR, 6 patients irradiation only (R), 3 patients both irradiation and chemotherapy (CR). The clinical response rate of the patients with R or CR was 33% (PR 3, MR 3, NC 3), and the histological effective (Ef 3 or Ef 2 ) rate was 56% (Ef 3 1, Ef 2 4, Ef 1 4). The clinical response rate of the patients with HCR was 88% (PR 7, MR 1), and the histological effective rate was 100% (Ef 3 1, Ef 2 7). HCR was more effective than R or CR for the local lesion of esophageal carcinoma histopathologically (p<0.05). However, the survival rate of patients with HCR was similar to R and CR, respectively. These results suggest that further improvement of the heating methods and the methods of combining hyperthermia with irradiation and chemotherapy is needed. (author)

  17. Clinico-statistical study of preoperative examination for the dental implant using multi-detector row computed tomography

    International Nuclear Information System (INIS)

    Sekiya, Keiko; Mori, Shintaro; Sekiya, Kotaro

    2008-01-01

    In April 2006, a new affiliated hospital opened at Nihon University School of Dentistry at Matsudo, and the latest model was introduced into the department of radiology. CT examinations for preoperative dental implant going on 64 multi-detector row CT, the number of cases has increased. CT examination is useful for preoperative dental implant, and many studies of concerning clinical studies using CT images have been reported. The purpose of this study was to the clinico-statistical studies of preoperative CT examinations for dental implant at our radiology department using 64 multi-detector row CT. The subjects consisted of 5174 regions in 1312 cases of preoperative CT examinations, between April 2006 and December 2007. CT machine used was the Aquilion TM 64 (Toshiba Medical Systems, Japan), and the workstation used was the ZIOSTATION (ZIOSOFT, Japan). All of CT examinations were performed the position of implant placement and disease examined from CT findings. The following results were obtained: The 1312 cases consisted of 426 males and 886 females. Patient age ranged from 16 yrs to 86 yrs old, the average age were 55.5 yrs old. Six hundred and seventy four cases were ordered at another private dental office not our hospital, and 638 cases were ordered at our hospital. The numbers of implant placement were on the average of 3.9, and the rate got higher with age. The lesions which detected by preoperative CT examination were maxillary sinusitis, periodontitis, ectopic calcification, and mucous retention cyst. (author)

  18. Gastritis OLGA-staging and gastric cancer risk: a twelve-year clinico-pathological follow-up study.

    Science.gov (United States)

    Rugge, M; de Boni, M; Pennelli, G; de Bona, M; Giacomelli, L; Fassan, M; Basso, D; Plebani, M; Graham, D Y

    2010-05-01

    Intestinal-type gastric cancer (GC) still ranks among the high-incidence, highly lethal malignancies. Atrophic gastritis is the cancerization field in which GC develops. The current histological reporting formats for gastritis do not include any (atrophy-based) ranking of GC risk. To test the gastritis OLGA-staging (Operative Link for Gastritis Assessment) in prognosticating neoplastic progression. Ninety-three Italian patients were followed up for more than 12 years (range: 144-204 months). Clinical examinations, pepsinogen serology, endoscopy and histology (also assessing Helicobacter pylori status) were performed both at enrolment (T1) and at the end of the follow-up (T2). All invasive or intra-epithelial gastric neoplasia were consistently associated with high-risk (III/IV) OLGA stages. There was a significant inverse correlation between the mean pepsinogen ratio and the OLGA stage (test for trend; P gastritis OLGA-staging conveys relevant information on the clinico-pathological outcome of gastritis and therefore for patient management. According to OLGA-staging and H. pylori-status, gastritis patients could be confidently stratified and managed according to their different cancer risks.

  19. Recurrent pyogenic cholangitis: clinico-pathologic correlation of focal attenuation differences on multi-phasic spiral CT

    International Nuclear Information System (INIS)

    Jeong, Jun Yong; Han, Joon Koo; Kim, Tae Kyoung; Kim, Seog Joon; Kim, Hyun Bum; Choi, Byung Ihn

    2002-01-01

    To determine the clinical and the pathologic significance of the focal attenuation differences (FAD) and bile duct wall enhancement occurring in recurrent pyogenic cholangitis (RPC) and seen at multiphasic spiral CT. Among the multiphasic (non-contrast, arterial and portal or delayed phase) spiral CT findings of 60 consecutive patients, two types of FAD were noted during the non-contrast phase. These were Type A (iso) and Type B (low attenuation), and their distribution pattern (lobar versus patchy, multifocal) and the and the presence or absence of bile duct wall enhancement were recorded. The radiologic findings were correlated with the clinical and pathologic findings. Two types of FAD were noted in 40 of the 60 patients. Active in flammation was present in 19 of the 27 with Type-A and in ten of the 15 in whom the presence of RPC was pathologically proven. Ten of the 13 with Type-B FAD were in a subclinical state, and nine of the ten in whom RPC was pathologically proven had chronic inflammation. Among 20 patients who did not have FAD, RPC was subclinical in 18 and dormant in nine of the eleven in whom its presence was pathologically proven (p<0.001). Clinico-pathologic correlation with bile duct wall enhancement and the distribution pattern of FAD showed no statistical significance. The inflammatory activity of RPC can be predicted by analysis of the FAD seen at multiphasic spiral CT

  20. Real-World Evidence In Support Of Precision Medicine: Clinico-Genomic Cancer Data As A Case Study.

    Science.gov (United States)

    Agarwala, Vineeta; Khozin, Sean; Singal, Gaurav; O'Connell, Claire; Kuk, Deborah; Li, Gerald; Gossai, Anala; Miller, Vincent; Abernethy, Amy P

    2018-05-01

    The majority of US adult cancer patients today are diagnosed and treated outside the context of any clinical trial (that is, in the real world). Although these patients are not part of a research study, their clinical data are still recorded. Indeed, data captured in electronic health records form an ever-growing, rich digital repository of longitudinal patient experiences, treatments, and outcomes. Likewise, genomic data from tumor molecular profiling are increasingly guiding oncology care. Linking real-world clinical and genomic data, as well as information from other co-occurring data sets, could create study populations that provide generalizable evidence for precision medicine interventions. However, the infrastructure required to link, ensure quality, and rapidly learn from such composite data is complex. We outline the challenges and describe a novel approach to building a real-world clinico-genomic database of patients with cancer. This work represents a case study in how data collected during routine patient care can inform precision medicine efforts for the population at large. We suggest that health policies can promote innovation by defining appropriate uses of real-world evidence, establishing data standards, and incentivizing data sharing.

  1. Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy

    International Nuclear Information System (INIS)

    Guiu, Boris; Krause, Denis; Cercueil, Jean-Pierre; Crevisy-Girod, Elodie; Binquet, Christine; Duvillard, Laurence; Masson, David; Lepage, Come; Hamza, Samia; Minello, Anne; Hillon, Patrick; Verges, Bruno; Petit, Jean-Michel

    2012-01-01

    The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI) are clinico-biological scores of steatosis validated in general or selected populations. Serum adiponectin (s-adiponectin) and retinol binding protein 4 (s-RBP4) are adipokines that could predict liver steatosis. We investigated whether the Steatotest, FLI, HSI, s-adiponectin and s-RBP4 could be valid predictors of liver steatosis in type-2 diabetic (T2D) patients. We enrolled 220 consecutive T2D patients. Reference standard was 3.0 T 1 H-MR spectroscopy (corrected for T1 and T2 decays). Intraclass correlation coefficients (ICCs), Kappa statistic measures of agreement, receiver operating characteristic (ROC) curves were assessed. Median liver fat content was 91 mg triglyceride/g liver tissue (range: 0-392). ICCs among the Steatotest, FLI, HSI, s-adiponectin, s-RBP4 and spectroscopy were low: 0.384, 0.281, 0.087, -0.297 and 0.048. Agreement between scores and spectroscopy was poor (Kappa range: 0.042-0.281). The areas under the ROC curves were low: 0.674, 0.647, 0.637, 0.616 and 0.540. S-adiponectin and s-RBP4 levels were strongly related to the presence of diabetic nephropathy (P = 0.0037 and P = 0.004; Mann-Whitney). The SteatoTest, FLI, HSI, s-adiponectin, s-RBP4 are not valid predictors of steatosis in T2D patients. Clino-biological markers cannot replace 1 H-MR spectroscopy for the assessment of liver fat in this population. (orig.)

  2. Neuroendocrine tumours of the ampulla of Vater: clinico-pathological features, surgical approach and assessment of prognosis.

    Science.gov (United States)

    Dumitrascu, Traian; Dima, Simona; Herlea, Vlad; Tomulescu, Victor; Ionescu, Mihnea; Popescu, Irinel

    2012-08-01

    Neuroendocrine tumours occur very rarely in the ampulla of Vater and their clinical behaviour is unknown. The aim of this study is to assess the clinico-pathological features, surgical approach and prognosis of these patients. Six patients with neuroendocrine tumours of the ampulla of Vater treated with curative intent surgery at a single centre were retrospectively analysed. A univariate analysis of potential prognostic factors was also performed (data provided from the present study and literature review). Pancreaticoduodenectomy was curative in all the patients. Overall and disease-free survival rates were significantly better for G1/G2 tumours (p = 0.006 and p = 0.004, respectively). Although frequent, lymph node metastases did not influenced both overall (p = 0.760) and disease-free survival rates (p = 0.745). No significant differences of survival were observed in patients with ENETS stage I/II disease, as compared to ENETS stage III disease (p = 0.169 and p = 0.137, respectively). No differences were observed according to UICC staging system (p = 0.073 and p = 0.177, respectively). Tumours that are less than 2 cm or limited to the ampulla appear to have a better prognosis. The WHO 2010 classification appear to accurately predict patient prognosis, while the ENETS or UICC staging systems have a limited value (especially in regard to lymph node metastases). Radical surgery (i.e. pancreaticoduodenectomy with lymphadenectomy) should be the standard approach in most patients with NET of the ampulla of Vater because this procedure removes all the potential tumour-bearing tissue.

  3. Impact of body mass index on clinico-pathological parameters and outcome in patients with metastatic prostate cancer

    International Nuclear Information System (INIS)

    Mohammed, A.A.; EL-Tanni, H.; Ghanem, H.M.; El Saify, A.M.; Al-Zahrani, A.S.; EL-Khatib, H.M.; Mohammed, A.A.; Farooq, M.U.; EL-Shentenawy, A.

    2015-01-01

    This study evaluates the correlation between body mass index (BMI) and clinico pathological parameters of metastatic prostate cancer (MPC) and its impact on survival. Method During the study period, 71 MPC patients were eligible. Patients with BMI < 25.0 kg/m2 were categorized as level I and patients with BMI ⩾ 25.0 kg/m2 were categorized as level II. Demographic features and survival rates were evaluated by the Kaplan–Meier method and Cox proportional models. Results 31 patients belonged to level I while the rest belonged to level II with insignificant higher median follow-up duration in level II; ρ=0.5. In terms of age, metastasis, serum level of albumin, prostatic specific antigen, alkaline phosphatase (AKP) and Gleason score, there was no significant difference between the two levels. The cumulative survival probability in the 12th, 24th and 36th month in level I vs; level II was; 86.7%, 68.7%, 64.1% vs; 74.4%, 67.7%, 55.1%, respectively with 7 patients dead in level I compared to 14 patients dead in level II denoting a higher PC-specific death rate in the level II group. In univariate and multivariate analysis, poor prognosis was associated with increasing AKP (HR = 1.0005, 95% CI, p = 0.03; HR=1.001, 95% CI, ρ=0.03) respectively, while better prognosis was associated with no visceral metastasis (HR = 0.09, 95% CI, ρ=0.000; HR = 0.04, 95% CI, ρ=0.000) and increasing albumin levels (HR = 0.17, 95% CI, ρ=0.000; HR = 0.15, 95% CI, ρ=0.000) respectively. In multivariate analysis only, patients belonging to level I were associated with better prognosis (HR = 0.17, 95% CI, ρ=0.02). Conclusion BMI is dependent on prognostic factors in patients with MPC

  4. Prediction for steatosis in type-2 diabetes: clinico-biological markers versus {sup 1}H-MR spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Guiu, Boris; Krause, Denis; Cercueil, Jean-Pierre [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Radiology, 2 boulevard Marechal de Lattre de Tassigny, BP 77908, Dijon (France); Crevisy-Girod, Elodie [CHU (University Hospital), Department of Endocrinology, Diabetology, and Metabolic Diseases, BP 77908, Dijon (France); Binquet, Christine [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Biostatistics and Medical Informatics, BP 77908, Dijon (France); Duvillard, Laurence [University of Burgundy, INSERM U866, BP 87900, Dijon (France); Masson, David [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Biochemistry, BP 77908, Dijon (France); Lepage, Come; Hamza, Samia; Minello, Anne; Hillon, Patrick [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Hepatology, BP 77908, Dijon (France); Verges, Bruno; Petit, Jean-Michel [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Endocrinology, Diabetology, and Metabolic Diseases, BP 77908, Dijon (France)

    2012-04-15

    The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI) are clinico-biological scores of steatosis validated in general or selected populations. Serum adiponectin (s-adiponectin) and retinol binding protein 4 (s-RBP4) are adipokines that could predict liver steatosis. We investigated whether the Steatotest, FLI, HSI, s-adiponectin and s-RBP4 could be valid predictors of liver steatosis in type-2 diabetic (T2D) patients. We enrolled 220 consecutive T2D patients. Reference standard was 3.0 T {sup 1}H-MR spectroscopy (corrected for T1 and T2 decays). Intraclass correlation coefficients (ICCs), Kappa statistic measures of agreement, receiver operating characteristic (ROC) curves were assessed. Median liver fat content was 91 mg triglyceride/g liver tissue (range: 0-392). ICCs among the Steatotest, FLI, HSI, s-adiponectin, s-RBP4 and spectroscopy were low: 0.384, 0.281, 0.087, -0.297 and 0.048. Agreement between scores and spectroscopy was poor (Kappa range: 0.042-0.281). The areas under the ROC curves were low: 0.674, 0.647, 0.637, 0.616 and 0.540. S-adiponectin and s-RBP4 levels were strongly related to the presence of diabetic nephropathy (P = 0.0037 and P = 0.004; Mann-Whitney). The SteatoTest, FLI, HSI, s-adiponectin, s-RBP4 are not valid predictors of steatosis in T2D patients. Clino-biological markers cannot replace {sup 1}H-MR spectroscopy for the assessment of liver fat in this population. (orig.)

  5. Clinico-Biochemical Correlation to Histological Findings in Alcoholic Liver Disease: A Single Centre Study from Eastern India

    Science.gov (United States)

    Khanra, Dibbendhu; Sonthalia, Nikhil; Kundu, Supratip; Biswas, Kaushik; Talukdar, Arunansu; Saha, Manjari; Bera, Himel

    2014-01-01

    Background: Alcoholism is a health problem not only in developed countries but also in developing countries. Cirrhosis due to alcohol is a common cause of death among individuals abusing alcohol. A better knowledge of the spectrum of alcoholic liver diseases, its clinical, biochemical and histopathological features could result in early detection and prevention of alcoholic liver diseases before it’s catastrophic and life threatening effects. Materials and Methods: A total of 200 patients with alcoholic liver diseases were studied with respect to alcohol consumption, clinical features, biochemical and histopathological changes. The clinical features, biochemical parameters, and histopathology of liver including Ishak’s modified histological activity index (HAI) were correlated with the amount and duration of alcohol consumed. Result: Majority of the patients were in the age group of 40-49 years and all the cases were males. Majority consumed alcohol of about 75-90 grams per day for a duration of 10–12 years. Anorexia and jaundice were the most common symptom and clinical finding respectively. Hyperbilirubinemia and hypoalbuminemia were the most common abnormalities observed in liver function tests. Advanced HAI stages with features of cirrhosis were most frequent histo-pathological finding noted in this study. Clinico-biochemical profile was significantly correlated with degree of alcohol ingestion as well as with liver histopathology. Conclusion: The wide prevalence of alcoholic liver disease including cirrhosis among Indian males was noted with significantly lower quantity and duration of alcohol ingestion. The severity of liver damage is directly proportional to the quantity and duration of alcohol consumed. Clinical features and biochemical changes may forecast the liver histopathology among the patients of alcoholic liver disease. PMID:25478382

  6. Andean cutaneous leishmaniasis (Andean-CL, uta) in Peru and Ecuador: the causative Leishmania parasites and clinico-epidemiological features.

    Science.gov (United States)

    Hashiguchi, Yoshihisa; Gomez, Eduardo A L; Cáceres, Abraham G; Velez, Lenin N; Villegas, Nancy V; Hashiguchi, Kazue; Mimori, Tatsuyuki; Uezato, Hiroshi; Kato, Hirotomo

    2018-01-01

    This study provides comprehensive information on the past and current status of the Andean cutaneous leishmaniasis (Andean-CL, uta) in Peru and Ecuador, mainly focusing on the causative Leishmania parasites and clinico-epidemiological features. Available information and data including our unpublished works were analyzed thoroughly. Endemic regions of the Andean-CL (uta) in Peru run from the north Piura/Cajamarca to the south Ayacucho at a wide range of the Pacific watersheds of the Andes through several departments, while in Ecuador those exist at limited and spotted areas in the country's mid-southwestern two provinces, Azuay and Chimborazo. The principal species of the genus Leishmania are completely different at subgenus level, L. (Viannia) peruviana in Peru, and L. (Leishmania) mexicana and L. (L.) major-like (infrequent occurrence) in Ecuador. The Peruvian uta is now prevalent in different age and sex groups, being not clearly defined as found in the past. The precise reasons are not known and should be elucidated further, though probable factors, such as emergence of other Leishmania parasites, non-immune peoples' migration into the areas, etc., were discussed briefly in the text. The Andean-CL cases in Ecuador are more rural than before, probably because of a rapid development of the Leishmania-positive communities and towns, and the change of life-styles of the inhabitants, including newly constructed houses and roads in the endemic areas. Such information is helpful for future management of the disease, not only for Leishmania-endemic areas in the Andes but also for other endemic areas. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Brain MRI lesions in neuromyelitis optica: clinical case; Lesiones cerebrales de resonancia magnetica en neuromielitis optica: caso clinico

    Energy Technology Data Exchange (ETDEWEB)

    Rosales Bravo, Luis Guillermo; Heyden Cordero, Marvin; Chinchilla Weinstok, Dennis; Mendelewicz Goldwaig, Isaias, E-mail: neurologia.cima@gmail.com [Caja Costarricense del Seguro Social, Hospital Mexico, Div. de Neurologia, San Jose (Costa Rica)

    2011-10-15

    Many cases of patients with neuromyelitis optica have submitted without demyelinating lesions in the cerebral white matter, it has documented that this entity can cause from the onset of illness or through its natural evolution. Diagnostic methods currently as Magnetic Resonance Imaging (MRI) and specific antibodies in plasma (such as antiaquaporin-4) have been diagnosed of neuromyelitis optica cases that were initially confused with multiple sclerosis. Disease in Costa Rica has been little prevalent and is not exactly known what the prevalence and incidence. The degree of disorder is illustrated through a case study, both in the cerebral white matter as spinal cord, in a patient with neuromyelitis optica during a follow-up period of 4 years. This is the first case that has been reported in the scientific literature of Costa Rica. (author) [Spanish] Muchos casos de pacientes con neuromielitis optica se han presentado sin lesiones desmielinizantes en la sustancia blanca cerebral, se ha documentado que esta entidad puede causarlas desde el inicio de la enfermedad o a traves de su evolucion natural. Los metodos de diagnostico en la actualidad como la Imagen por Resonancia Magnetica (IRM) y la determinacion de anticuerpos especificos en plasma (como la antiaquaporina-4) han logrado diagnosticar algunos casos de neuromielitis optica que inicialmente fueron confundidos con esclerosis multiple. La enfermedad en Costa Rica ha sido poco prevalente y no se ha conocido con exactitud cual es la prevalencia e incidencia. El grado de afeccion ha sido ilustrado a traves de un caso clinico, tanto en la sustancia blanca cerebral como espinal, en un paciente con neuromielitis optica durante un periodo de seguimiento de 4 anos. Este es el primer caso que ha sido reportado en la literatura cientifica de Costa Rica. (autor)

  8. Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinico-pathologic and immunohistochemical findings in cysts treated by enucleation.

    Science.gov (United States)

    Kuroyanagi, Norio; Sakuma, Hidenori; Miyabe, Satoru; Machida, Junichiro; Kaetsu, Atsuo; Yokoi, Motoo; Maeda, Hatsuhiko; Warnakulasuriya, Saman; Nagao, Toru; Shimozato, Kazuo

    2009-04-01

    The purpose of this study was to determine prognostic factors for the recurrence of keratocystic odontogenic tumors (KCOTs) following simple enucleation by examining clinico-pathologic and immunohistochemical findings. Following enucleation, the frequency of recurrence among 32 subjects diagnosed with KCOT was analyzed for tumor site, radiographic and histologic features, and immunopositivity for Ki-67 and p53. Keratocystic odontogenic tumors in four out of 32 subjects (12.5%) recurred during the follow-up period (median: 33 months, range: 7-114 months). Three out of four subjects (75.0%) among recurrent group showed high expression of Ki-67 (LI >10%) in basal layer and four (4/28; 14.3%) among non-recurrence group (P = 0.025). Expression of p53 among non-recurrent group was observed in 11 subjects (11/28; 39.3%), and in three subjects (3/4; 75.0%) among the recurrent group (P = 0.295). Hazard risk for the recurrence of KCOT was 4.02 (95% CI 1.42-18.14) for high Ki-67 expression in the basal layer by the Cox proportional hazard model (P = 0.009). In our study, none of the other clinico-pathologic variables were associated with the recurrence of KCOT. The results suggested that the evaluation of Ki-67 expression in KCOT at the time of pathological diagnosis might be helpful for consideration of appropriate adjunctive surgical procedures to avoid a recurrence and may serve as a prognostic marker.

  9. A comparison of the time required by radiologists for the preparation of clinico-radiological meetings when film and PACS are used

    International Nuclear Information System (INIS)

    Weatherburn, G.; Bryan, S.; Cousins, C.

    2000-01-01

    The hypothesis was that when a hospital-wide Picture Archive and Communications System (PACS) is used, preparation for clinico-radiological meetings is faster, and more images are available, than when a conventional film system is used. This paper reports a study which compared the preparation time by radiologists when film was used with the time for the same activity when a hospital-wide PACS was used at Hammersmith Hospital for the preparation of the respiratory medicine and hepato-biliary meetings. It was found that when PACS was used the time per patient to prepare for the respiratory medicine session was reduced by 11.1 min and that similarly, 16 min per patient was saved in the preparation of the hepato-biliary sessions. The number of images which were unavailable for the session was reduced when PACS was in operation, but this reduction was not shown to be statistically significant. The introduction of PACS at Hammersmith Hospital has significantly reduced the time spent by radiologists in preparing for the two clinico-radiological sessions studied and, if this is extended to the other numerous sessions held each week, contributes to a considerable saving of staff time within the radiology department. (orig.)

  10. Health status of the elderly population among four primitive tribes of Orissa, India: a clinico-epidemiological study.

    Science.gov (United States)

    Kerketta, A S; Bulliyya, G; Babu, B V; Mohapatra, S S S; Nayak, R N

    2009-02-01

    Primitive tribal groups (PTGs) are the most marginalised and vulnerable communities in India. Clinico-epidemiological studies on morbidity patterns among the elderly primitive tribe members are essential to recommend special intervention programmes to improve the health of the elderly in these communities. A community-based cross-sectional study was carried out among the elderly populations of four different PTGs, namely Langia Saora (LS), Paudi Bhuiyan (PB), Kutia Kondh (KK) and Dongria Kondh (DK) living in the forests of Orissa, India. Clinical and anthropometric data were collected using standard methods and haemoglobin was estimated by the cyanomethaemoglobin method. The average number of illnesses per person was 3.0. Common disabilities like vision and hearing impairment and mobility-related problems were found in considerable numbers. Gastrointestinal problems like acid peptic disease were found among 2.6% to 20% of cases. Non-specific fever was marked in 10.2% to 24.2% of individuals. The iodine deficiency disorder, namely goitre, was found among 4.2% to 6.0% of individuals. Diseases of the respiratory tract, like upper and lower respiratory tract infection, asthma, tuberculosis and leprosy, were found in small numbers. The prevalence of hypertension among males and females was 31.8% and 42.2%, respectively. The LS had the highest prevalence of hypertension (63% among men and 68% among women). With regard to anaemia status, severe anaemia was marked in 70% of males and 76.7% of females in the LS, while in other groups the prevalence of severe anaemia ranged from 15% to 33%. Although the prevalence of severe anaemia in other tribal communities is lower than in the LS, mild to moderate anaemia was found to range from 60% to 80%. The present study revealed a high prevalence of physical disabilities with both non-communicable as well as communicable diseases among the elderly primitive tribal members. This warrants the implementation of a special health care

  11. Mass spectrometry protein expression profiles in colorectal cancer tissue associated with clinico-pathological features of disease

    International Nuclear Information System (INIS)

    Liao, Christopher CL; Ward, Nicholas; Marsh, Simon; Arulampalam, Tan; Norton, John D

    2010-01-01

    Studies of several tumour types have shown that expression profiling of cellular protein extracted from surgical tissue specimens by direct mass spectrometry analysis can accurately discriminate tumour from normal tissue and in some cases can sub-classify disease. We have evaluated the potential value of this approach to classify various clinico-pathological features in colorectal cancer by employing matrix-assisted laser desorption ionisation time of-flight-mass spectrometry (MALDI-TOF MS). Protein extracts from 31 tumour and 33 normal mucosa specimens were purified, subjected to MALDI-Tof MS and then analysed using the 'GenePattern' suite of computational tools (Broad Institute, MIT, USA). Comparative Gene Marker Selection with either a t-test or a signal-to-noise ratio (SNR) test statistic was used to identify and rank differentially expressed marker peaks. The k-nearest neighbours algorithm was used to build classification models either using separate training and test datasets or else by using an iterative, 'leave-one-out' cross-validation method. 73 protein peaks in the mass range 1800-16000Da were differentially expressed in tumour verses adjacent normal mucosa tissue (P ≤ 0.01, false discovery rate ≤ 0.05). Unsupervised hierarchical cluster analysis classified most tumour and normal mucosa into distinct cluster groups. Supervised prediction correctly classified the tumour/normal mucosa status of specimens in an independent test spectra dataset with 100% sensitivity and specificity (95% confidence interval: 67.9-99.2%). Supervised prediction using 'leave-one-out' cross validation algorithms for tumour spectra correctly classified 10/13 poorly differentiated and 16/18 well/moderately differentiated tumours (P = < 0.001; receiver-operator characteristics - ROC - error, 0.171); disease recurrence was correctly predicted in 5/6 cases and disease-free survival (median follow-up time, 25 months) was correctly predicted in 22

  12. Mass spectrometry protein expression profiles in colorectal cancer tissue associated with clinico-pathological features of disease

    Directory of Open Access Journals (Sweden)

    Liao Christopher CL

    2010-08-01

    Full Text Available Abstract Background Studies of several tumour types have shown that expression profiling of cellular protein extracted from surgical tissue specimens by direct mass spectrometry analysis can accurately discriminate tumour from normal tissue and in some cases can sub-classify disease. We have evaluated the potential value of this approach to classify various clinico-pathological features in colorectal cancer by employing matrix-assisted laser desorption ionisation time of-flight-mass spectrometry (MALDI-TOF MS. Methods Protein extracts from 31 tumour and 33 normal mucosa specimens were purified, subjected to MALDI-Tof MS and then analysed using the 'GenePattern' suite of computational tools (Broad Institute, MIT, USA. Comparative Gene Marker Selection with either a t-test or a signal-to-noise ratio (SNR test statistic was used to identify and rank differentially expressed marker peaks. The k-nearest neighbours algorithm was used to build classification models either using separate training and test datasets or else by using an iterative, 'leave-one-out' cross-validation method. Results 73 protein peaks in the mass range 1800-16000Da were differentially expressed in tumour verses adjacent normal mucosa tissue (P ≤ 0.01, false discovery rate ≤ 0.05. Unsupervised hierarchical cluster analysis classified most tumour and normal mucosa into distinct cluster groups. Supervised prediction correctly classified the tumour/normal mucosa status of specimens in an independent test spectra dataset with 100% sensitivity and specificity (95% confidence interval: 67.9-99.2%. Supervised prediction using 'leave-one-out' cross validation algorithms for tumour spectra correctly classified 10/13 poorly differentiated and 16/18 well/moderately differentiated tumours (P = P = P = 0.001; ROC error, 0.212. Conclusions Protein expression profiling of surgically resected CRC tissue extracts by MALDI-TOF MS has potential value in studies aimed at improved molecular

  13. Surgical treatment of pathological obesity; Tratamiento quirurgico de la obesidad patologica

    Energy Technology Data Exchange (ETDEWEB)

    Portie Felix, Antonio; Navarro Sanchez, Gustavo; Hernandez Solar, Abel; Grass Baldoquin, Jorge Alberto; Domloge Fernandez, Joana, E-mail: antonio.portilles@infomed.sld.cu [Hospital Universitario General Calixto Garcia, La Havana (Cuba)

    2011-07-01

    The obesity is the chronic non-communicable disease with a higher rate of growth in past 20 years. It is a risk factor for type 2 diabetes mellitus, high blood pressure, cardiovascular and respiratory affections, infertility, sexual and functional impotence, metabolic syndrome, load joint disorders and some types of cancer (breast, colon, prostate). The metabolic bariatric surgery is the surgical treatment more effective for the morbid obesity at long -and medium- term and not the pharmacologic treatment and the isolated diets. The aim of present historical review of the international literature on the evolution of surgical techniques of the bariatric surgery (malabsorption techniques, gastric restrictive techniques and mixed techniques), is to make available to those interested in this subject, a valuable therapeutic tool to be rationally used. (author)

  14. Genetic counselling, BRCA1/2 status and clinico-pathologic characteristics of patients with ovarian cancer before 50 years of age

    Directory of Open Access Journals (Sweden)

    Cvelbar Mirjam

    2017-05-01

    Full Text Available In Slovenia like in other countries, till recently, personal history of epithelial ovarian cancer (EOC has not been included among indications for genetic counselling. Recent studies reported up to 17% rate of germinal BRCA1/2 mutation (gBRCA1/2m within the age group under 50 years at diagnosis. The original aim of this study was to invite to the genetic counselling still living patients with EOC under 45 years, to offer gBRCA1/2m testing and to perform analysis of gBRCA1/2m rate and of clinico-pathologic characteristics. Later, we added also the data of previously genetically tested patients with EOC aged 45 to 49 years.

  15. Radiation protection of patients in medical exposures: regional project IAEA 2007-2008 RLA/9/57;Proteccion radiologica de pacientes en exposiciones medicas: proyecto regional IAEA 2007-2008 RLA/9/57

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    -area product (Pk, a); Mammography theme contains: Application and criteria for image quality: a study of the mammography - skull flow, Sheet for data collection in patients CC and MLO, Sheet for data collection in mammography practices, include equipment description, determination of yields, Hemi reducer thickness, determination of {sup c,} data from the patient and glandular dose; Tomography theme contains: General data about computed tomography services in the Hospital Max Peralta which include report of tests and dosimetry in phantom, in air, information from used scanners; Radiology theme contains: Dosimetry of patients in general radiology where shows forms for determining the performance of x-ray tube; Minimum values, maximum and Kerma in air average in surface of entry for PA Chest radiographs; Measures to generate the yield curve; Patient data, the technical parameters and image quality; Forms by country; Kerma in air at the entrance to the PA Chest skin, the dosimetry in general radiology is included with practices and methodology for the measurement and evaluation, also shows forms with protocols for measurements with TLDS;La proteccion radiologica de pacientes en exposiciones medicas como proyecto esta integrado por 5 regionales que abarcan unos 80 paises, 94 hospitales y 120 actividades relacionadas con radiologia y radiacion. Un taller fue desarrollado con los siguientes objetivos: proporcionar los elementos teoricos y practicos para que los profesionales en proteccion radiologica de pacientes desarrollen tareas encomendadas, identificar la metodologia de medicion mediante hojas para la captura de datos e interpretacion de los mismos, realizar ejercicios practicos de los procedimientos a aplicar en radiologia, mamografia, tomografia computarizada e intervencionismo. Dicho taller se dividio en secciones teoricas y practicas, secciones de analisis e interpretacion de datos y un examen final. Este proyecto pretende identificar fortalezas y debilidades, objetivos

  16. Radiation protection of patients in medical exposures: regional project IAEA 2007-2008 RLA/9/57; Proteccion radiologica de pacientes en exposiciones medicas: proyecto regional IAEA 2007-2008 RLA/9/57

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    -area product (Pk, a); Mammography theme contains: Application and criteria for image quality: a study of the mammography - skull flow, Sheet for data collection in patients CC and MLO, Sheet for data collection in mammography practices, include equipment description, determination of yields, Hemi reducer thickness, determination of {sup c,} data from the patient and glandular dose; Tomography theme contains: General data about computed tomography services in the Hospital Max Peralta which include report of tests and dosimetry in phantom, in air, information from used scanners; Radiology theme contains: Dosimetry of patients in general radiology where shows forms for determining the performance of x-ray tube; Minimum values, maximum and Kerma in air average in surface of entry for PA Chest radiographs; Measures to generate the yield curve; Patient data, the technical parameters and image quality; Forms by country; Kerma in air at the entrance to the PA Chest skin, the dosimetry in general radiology is included with practices and methodology for the measurement and evaluation, also shows forms with protocols for measurements with TLDS;La proteccion radiologica de pacientes en exposiciones medicas como proyecto esta integrado por 5 regionales que abarcan unos 80 paises, 94 hospitales y 120 actividades relacionadas con radiologia y radiacion. Un taller fue desarrollado con los siguientes objetivos: proporcionar los elementos teoricos y practicos para que los profesionales en proteccion radiologica de pacientes desarrollen tareas encomendadas, identificar la metodologia de medicion mediante hojas para la captura de datos e interpretacion de los mismos, realizar ejercicios practicos de los procedimientos a aplicar en radiologia, mamografia, tomografia computarizada e intervencionismo. Dicho taller se dividio en secciones teoricas y practicas, secciones de analisis e interpretacion de datos y un examen final. Este proyecto pretende identificar fortalezas y debilidades, objetivos

  17. NonScarring Diffuse Hair Loss in Women: a Clinico-Etiological Study from tertiary care center in North-West India.

    Science.gov (United States)

    Poonia, Kavita; Thami, Gurvinder Pal; Bhalla, Mala; Jaiswal, Shivani; Sandhu, Jasleen

    2018-05-17

    Diffuse hair loss (DHL) is a common problem in adult women and has a major impact on quality of life. Ascertaining the etiological diagnosis is a challenging task in such patients. Satisfactory treatment can only be instituted after ascertaining the cause of hair loss. To study the clinico-epidemiological profile of nonscarring DHL in females and to ascertain its underlying etiological factors. Of a total of 110 females, who presented with nonscarring DHL to the outpatient dermatology department, 100 qualified for inclusion in the study. A detailed history, clinical examination, and laboratory investigations were performed in all the patients. Statistical analysis was performed on the data collected. Of 100 cases of DHL which were included in the study, commonest was chronic telogen effluvium (CTE) (62%), followed by female pattern hair loss (FPHL) (22%) and acute telogen effluvium (ATE) (16%). Incidence of hair loss was highest in 21-40 years age group. Psychological stress was seen to be a precipitating factor in 18 patients and found most commonly in women belong to CTE group (n-16, 25.8%). Hemoglobin levels ranged from 80 to 142 gm/L (mean: 119 ± 110). Low hemoglobin level (hair loss, and their supplementation may be needed for a faster regrowth of hair in all cases of hair loss irrespective of the pattern. © 2018 Wiley Periodicals, Inc.

  18. [Non-metastatic clear cell renal cancer: dependence of the tumour stage on clinico-anatomic and morphologic factors; prognostic value of macro- and karyometric characteristics].

    Science.gov (United States)

    Iurin, A G

    2010-01-01

    Non-metastatic clear-cell renal cancer: dependence of the tumour stage on clinico-anatomic and morphologic factors; prognostic value of macro- and karyometric characteristics Sankt Peterburg Pathology Bureau, Sankt Peterburg It was shown based on multivariate regression analysis that pT1a3bN0MO stages of non-metastatic clear-cell renal cancer significantly correlate not only with the tumor size and invasion into the fatty tissue and/or renal vein but also with the invasion into the renal capsule and with the mean maximum diameter and mean nucleus area of tumor cells. There was no correlation of clear-cell renal cancer stages with tumor proliferative activity, gene p53 mutation, oncosuppressor gene PTEN expression, fraction of tumour clear-cell component, and such clinical characteristics as patients' sex, age, and body mass index. Taking into account statistically significant differences between the patients' survival rates, the regression equations developed in this work may be used for the prediction of disease outcome.

  19. Validation of the prognostic gene portfolio, ClinicoMolecular Triad Classification, using an independent prospective breast cancer cohort and external patient populations

    Science.gov (United States)

    2014-01-01

    Introduction Using genome-wide expression profiles of a prospective training cohort of breast cancer patients, ClinicoMolecular Triad Classification (CMTC) was recently developed to classify breast cancers into three clinically relevant groups to aid treatment decisions. CMTC was found to be both prognostic and predictive in a large external breast cancer cohort in that study. This study serves to validate the reproducibility of CMTC and its prognostic value using independent patient cohorts. Methods An independent internal cohort (n = 284) and a new external cohort (n = 2,181) were used to validate the association of CMTC between clinicopathological factors, 12 known gene signatures, two molecular subtype classifiers, and 19 oncogenic signalling pathway activities, and to reproduce the abilities of CMTC to predict clinical outcomes of breast cancer. In addition, we also updated the outcome data of the original training cohort (n = 147). Results The original training cohort reached a statistically significant difference (p risk groups. Conclusions Both prospective internal cohorts and the independent external cohorts reproduced the triad classification of CMTC and its prognostic significance. CMTC is an independent prognostic predictor, and it outperformed 12 other known prognostic gene signatures, molecular subtype classifications, and all other standard prognostic clinicopathological factors. Our results support further development of CMTC portfolio into a guide for personalized breast cancer treatments. PMID:24996446

  20. Non-Small-Cell Lung Cancer Clinico pathologic Features and Survival Outcomes in Asian Pacific Islanders Residing in the United States: A SEER Analysis

    International Nuclear Information System (INIS)

    Hamid, M. S.; Shameem, R.; Gafoor, K.; George, J.; Mina, B.; Sullivan, K.

    2015-01-01

    The objective of our study was to ascertain racial/ethnic disparities in Asian/Pacific Islanders (API) for non-small-cell lung cancer (NSCLC) clinico pathologic features and survival outcomes based on various tumor characteristics and treatment modalities. Method. SEER database identified invasive NSCLC cases from 2004 to 2010. Variables included American Joint Committee on Cancer (AJCC) stage 7, tumor grade, tumor size, histology, age, marital status, radiation, surgery, and reason for no surgery. The Kruskall-Wallis test and the Z test were used to examine differences between races/ethnicities and the referent, non-Hispanic white (NHW). Multivariate Cox proportional analyses were used to establish the weight of the prognostic significance contributing to disease-specific survival (DSS) in each AJCC stage. Result. Improved DSS was seen in API across stage I (HR: 0.78), stage II (HR: 0.79), and stage IV (HR: 0.86), respectively, compared to the referent NHW (P<0.01). being female gender, AIS histology, and birth outside the US (P<0.01). Conclusion. We have demonstrated improved survival among API in early stage and stage IV NSCLC. Further research is necessary to clarify the role of lifestyle and tumor biology for these differences.

  1. Clinico-statistical study on the patients who were applied preoperative CT imaging for dental implant treatment in Iwate Medical University Hospital

    International Nuclear Information System (INIS)

    Shoji, Satoru; Izumisawa, Mitsuru; Satoh, Hitoshi; Hoshino, Masayuki; Takahashi, Noriaki; Shozushima, Masanori; Nakasato, Tatsuhiko

    2007-01-01

    The diagnosis of jaw bones using X-ray computed tomography (CT) is important to determine placement of dental implants. A Clinico-statistical study were made on 490 cases which applied preoperative dental mutiplannar reconstructing CT (dental MPR) imaging for dental implant treatment in Iwate Medical University Hospital, during a five-year period from 2002 to 2006. The following results were obtained: The 490 cases consisted of 179 males and 311 females. They ranged in age from 16 to 80 years, the average age was 53.6 years old. The largest number of cases were in their 50's and, in most generations, there were more female cases than male. Similar cases have been increasing every year. Most patients were referred from other clinics to our hospital. Of the cases that underwent CT scanning more were mandible than maxilla. Implantation prearranged region revealed a predominance of mandible in anterior teeth, and maxilla in molar teeth. The cases that were using diagnostic surgical stents increased in the first three years, but were constant afterwards. (author)

  2. Relationships between socio-clinico-demographic factors and global cognitive function in the oldest old living in the Tokyo Metropolitan area: Reanalysis of the Tokyo Oldest Old Survey on Total Health (TOOTH).

    Science.gov (United States)

    Eguchi, Yoko; Tasato, Kumiko; Nakajima, Shinichiro; Noda, Yoshihiro; Tsugawa, Sakiko; Shinagawa, Shunichiro; Niimura, Hidehito; Hirose, Nobuyoshi; Arai, Yasumichi; Mimura, Masaru

    2018-03-07

    Despite a steady increase in life expectancy, a few studies have investigated cross-sectional correlates and longitudinal predictors of cognitive function, a core domain of the successful aging, among socio-clinico-demographic factors in the oldest-old exclusively. The aims of this study were to examine socio-clinico-demographic characteristics associated with global cognition and its changes in the oldest-old. We reanalyzed a dataset of cognitively preserved community-dwelling subjects aged 85 years and older in the Tokyo Oldest Old Survey on Total Health, a 6-year longitudinal observational study. This study consisted of (1) baseline cross-sectional analyses examining correlates of global cognition (n = 248) among socio-clinico-demographic factors and (2) longitudinal analyses examining baseline predictors for changes of global cognition in 3-year follow-up (n = 195). The Mini-Mental State Examination was used as a screening test to assess global cognition. At baseline, higher weights were related to higher cognitive function in the oldest-old. The baseline predictors of global cognitive decline in 3-year follow-up were higher global cognition, shorter education period, and lower sociocultural activities and lower instrumental activity of daily living, in this order. The present study suggests that it is crucial to attain higher education during early life and avoid leanness or obesity, participate in sociocultural cognitive activities during late life, and maintain instrumental activity of daily living to preserve optimal cognitive function in the oldest-old, which will facilitate developing prevention strategies for cognitive decline and promoting successful aging in this increasing population. Copyright © 2018 John Wiley & Sons, Ltd.

  3. Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: A study of the TGRbetaRII, BAX, hMSH3, hMSH6, IGFIIR and BLM genes.

    Science.gov (United States)

    Calin, G A; Gafà, R; Tibiletti, M G; Herlea, V; Becheanu, G; Cavazzini, L; Barbanti-Brodano, G; Nenci, I; Negrini, M; Lanza, G

    2000-05-20

    Colon carcinomas with microsatellite mutator phenotype exhibit specific genetic and clinico-pathological features. This report describes the analysis of 63 "microsatellite instability-high" (MSI-H) tumors for the presence of mutations in microsatellites located in the coding regions (CDRs) of 6 genes: TGFbetaRII, BAX, hMSH3, hMSH6, IGFIIR, and BLM. The following frequencies of mutations were detected: TGFbetaRII (70%), BAX (54%), hMSH3 (36.5%), IGFIIR (22%), hMSH6 (17.5%), and BLM (16%). The overall picture revealed combinations of mutations suggestive of a progressive order of accumulation, with mutations of TGFbetaRII and BAX first, followed by frameshifts in hMSH3, hMSH6, IGFIIR, and BLM. Correlations with 12 clinico-pathological parameters revealed that tumors with frameshifts in 1 or 2 CDRs were significantly better differentiated than tumors with frameshifts in more than 2 CDRs. We also found that mutations in the hMSH3 gene were significantly associated with decreased wall invasiveness and aneuploidy, and frameshifts in the BLM gene were significantly associated with the mucinous histotype. A trend toward an association between hMSH3 and IGFIIR with the medullary and conventional adenocarcinoma histotypes, respectively, was seen. Our results strengthen the concept that mutations in target genes have a role in the tumorigenic process of MSI-H tumors, and indicate that frameshifts in microsatellites located in CDRs occur in a limited number of combinations that could determine distinct clinico-pathological traits. Copyright 2000 Wiley-Liss, Inc.

  4. Radiological clinical correlation of pulmonary and extrapulmonary tuberculosis with CD4 T lymphocyte counts in patients with V.I.H. in the San Juan de Dios Hospital during the period 2004 to the first half of 2009; Correlacion clinico radiologica de la tuberculosis pulmonar y extrapulmonar con el conteo de linfocitos T CD4 en pacientes con V.I.H. en el Hospital San Juan de Dios durante el periodo 2004 hasta el primer semestre de 2009

    Energy Technology Data Exchange (ETDEWEB)

    Campos Fallas, Christian

    2010-07-01

    The association between radiographic presentation of tuberculosis (TB), pulmonary and extrapulmonary, and the count of CD4 T lymphocytes in patients infected with Human Immunodeficiency Virus (HIV), are investigated. The order has been to achieve a diagnosis and isolation early of coinfected patients. A retrospective analysis was performed of the clinical history, chest radiograph, CD4 T lymphocyte count of 25 HIV-infected patients with documented pulmonary or extrapulmonary tuberculosis diagnosis. 18 patients diagnosed (72%) with radiologic atypical skipper, 14 of them with significant immunosuppression (TB patients with CD4 T count <200 / mm {sup 3}), while only 6 (24%) with radiologic typical skipper of TB was associated with negative sputum smears (p=0.06). In HIV patients with CD4 T lymphocyte counts T <200 / mm {sup 3}, no respiratory symptoms and atypical radiographic pattern, may be suspected active TB, even with negative sputum smears. (Author) [Spanish] La asociacion entre la presentacion radiografica de tuberculosis (TB), pulmonar y extrapulmonar, y el conteo de linfocitos T CD4 en pacientes con infeccion por Virus de Inmuno Deficiencia Humana (VIH), son investigados. El fin ha sido lograr un diagnostico y aislamiento temprano de pacientes coinfectados. Un analisis retrospectivo fue realizado de la historia clinica, radiografia de torax, conteo de Linfocitos T CD4, de 25 pacientes con infeccion por VIH con diagnostico documentado de tuberculosis pulmonar o extrapulmonar. 18 pacientes diagnosticados (72%) con patron radiologico atipico, 14 de ellos con inmunosupresion significativa (pacientes con TB con conteo de Linfocitos T CD4 <200/mm{sup 3}), mientras que solo 6 (24%) con patron radiologico tipico de TB fue asociado con baciloscopias negativas, (p=0.06). En pacientes con VIH con conteos de Linfocitos T CD4 <200/mm{sup 3}, no sintomaticos respiratorios y con patron radiologico atipico, puede ser sospechado TB activa, aun con baciloscopias negativas. (autor)

  5. Clinico-pathological features and prognosis of invasive micropapillary carcinoma compared to invasive ductal carcinoma: a population-based study from China.

    Directory of Open Access Journals (Sweden)

    Wen-Biao Shi

    Full Text Available Invasive micropapillary carcinoma (IMPC of the breast is a rare subtype of breast cancer that is associated with a high incidence of regional lymph node metastases and a poor clinical outcome. However, the clinico-pathological features and prognostic factors of IMPC are not well understood.A total of 188 IMPC cases and 1,289 invasive ductal carcinoma (IDC cases were included. The clinical features, breast cancer-specific survival (BCSS and recurrence/metastasis-free survival (RFS of the patients were compared between these two groups.The IMPC patients exhibited more features of aggressive carcinoma than the IDC patients, including larger tumor size, higher tumor stage, a greater proportion of nodal involvement and an increased incidence of lymphovascular invasion. Patients with IMPC had lower 5-year BCSS and RFS rates (75.9% and 67.1%, respectively than patients with IDC (89.5% and 84.5%, respectively. Compared to IDC patients, the patients with IMPC had a significantly higher percentage of stage III breast cancer (51.3% versus 21.7%. In a stage-matched Kaplan-Meier analysis, the patients with stage III IMPC had lower 5-year BCSS and RFS rates than patients with stage III IDC (BCSS, P = 0.004; RFS, P = 0.034. A multivariate analysis revealed that TNM stage was an independent prognostic factor for patients with IMPC. The proportion of cancers with a luminal-like subtype was significantly higher in IMPC than in IDC (P<0.001. However, after matching by molecular subtype, the patients with IMPC had significantly worse clinical outcomes than patients with IDC.In Chinese women, IMPCs displayed more aggressive behaviors than IDCs, resulting in poorer clinical outcomes for patients with IMPC, regardless of a favorable molecular subtype. Our findings illustrate that the poorer survival of patients with IMPC might be due to an increased incidence and aggressiveness of tumors in TNM stage III.

  6. Tumoral expression on Her-2, E R and P R and its Clinico pathological characteristics relation in Uruguayan and Argentine patients with operable breast cancer

    International Nuclear Information System (INIS)

    Delgado, L; Richardet, E; Pallotta, G; Fresco, R; Aguiar, S; Camejo, N; Gonzalez, V; Ferrero, L; Heinzen, S; Martinez, A. and others

    2010-01-01

    Introduction: the study of biological subtype of breast cancer (B C) given by the expression tumor estrogen receptors (E R), progesterone (P R) and growth factor receptor and evolutionary. Objective: To know the profile of tumor expression of HER2, ER and P R and their relation with to characteristics clinico pathological characteristics in Uruguayan and Argentine patients with breast cancer. Material and Methods: The medical records of patients who underwent analyzed C M I-III invasive stages between 03/2006 and 03/2008 and assisted in Oncology Services where the authors are performing, which had selected determination ER, P R and HER2 by immunohistochemistry. The expression profile of these was markers compared with age at diagnosis, type and histological grade (GH) and pathological stage (TNM). Results: 291 patients (197 Uruguayan and 94 Argentine) were included whose characteristics were: mean age: 56 years, ductal carcinoma: 85%, GH 1-2: 55% stage I-II: 70%, metastasis axillary: 51%, ER / P R +: 78% HER2 + 12%. Three subtypes were defined: HER2 ER / P R + (71%), HER2 + (12% Uruguayan patients: 10%, Argentine patients: 17%) and negative Triple (TN) (17%). The joint analysis of the patients in both countries showed that subtypes TN and HER2 is associated with greater histological grade (p <0.05). Furthermore, in the group of patients Uruguayan, TN subtype was associated with younger age at diagnosis (p <0.05) subtype HER2, ER / PR +. Conclusions: The percentage of patients with CM Uruguayan invasive HER2 + subtype (10%) is smaller than that reported by other studies (17-28%) and that observed in our study Argentine group of patients. Consistent with previous studies, TN subtypes and HER2 + correlated with more undifferentiated tumors and in the group of Uruguayan patients TN appeared in younger patients

  7. Clinico-psycho-social profile of patients brought under consultation-liaison psychiatry care in a large tertiary care referral hospital

    Directory of Open Access Journals (Sweden)

    P Patra

    2017-01-01

    Full Text Available Objective: The aim of this study was to access the clinico-psycho-social profile of patients brought under consultation-liaison (CL psychiatry care in a large tertiary care referral hospital. Materials and Methods: This study included all patients who were referred for CL psychiatry from among the inpatients in the hospital and the emergency department (during off working hours of the hospital over a period of 1 year. Data were obtained and analyzed in terms of where was the referral placed, by whom, the reason for placing the referral, the primary medical/surgical diagnosis of the patient, the presenting complaints, any past psychiatric history, the psychiatric diagnosis (as per the International Classification of Diseases, Tenth Edition, the investigations advised and their reports, the treatment advised (psychotherapeutic and psychopharmacological, the sociodemographic profile of the patients, and the follow-up details. Results: A total of 157 patients were referred to the CL unit over the study period. Out of these, 125 patients were referred among the inpatients and 32 from the emergency department of the hospital. Majority of the patients were in the age group of 25–50 years and were male. The majority of the referrals were made by general physician; most of the referrals were placed from emergency department. The most common reason for referral was for altered sensorium and behavioral abnormalities. The most common diagnosis was delirium followed by depressive episode and alcohol dependence syndrome. Conclusion: There was higher representation of delirium and alcohol-related cases in our study compared to older studies.

  8. Clinico-Pathological Profile and Outcomes of Patients with Polycythaemia Vera, Essential Thrombocythaemaia and Idiopathic Myelofibrosis: A Tertiary Care Center Experience from Southern Pakistan

    International Nuclear Information System (INIS)

    Shaikh, M. S.; Shaikh, M. U.; Adil, S. N.; Ahmed, Z. A.; Khurshid, M.

    2016-01-01

    Background: The P hiladelphia Negative Classic Myeloproliferative Neoplasms include polycythaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF). These three disorders share several clinical and laboratory features including JAK2 V617F mutation. Our objectives were to determine the clinico-pathological profile and outcomes of Pakistani patients with polycythaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF) in order to have an insight regarding behaviour of these conditions. Methods: A retrospective analysis of all the cases of PV, ET and IMF diagnosed at our institute from January 1995 to December 2013 was performed. Age, gender, clinical presentation, laboratory investigations, treatment provided and duration of follow-up were included for analysis. Appropriate statistics were utilized for calculation of data. Results: A total of 58 patients were diagnosed as PV, ET or IMF during the study period. Male to female ratio was 1.1:1. Forty five percent (n=27) patients came to medical attention due to abnormal laboratory results, 3 had cerebrovascular events, 3 had pruritus, and 1 patient each with gangrene and Budd-Chiari syndrome. Haemorrhage was not seen in any patient. Sixty percent (n=35) patients were treated with phlebotomy, hydroxyurea and aspirin alone or in combination. None of the patients transformed to myelofibrosis (MF) or myelodysplasia (MDS) during the mean (±SD) follow-up period of 57.2±50 months. One patient with ET transformed to acute myeloid leukaemia 9 years after the diagnosis. Conclusions: This study demonstrated a relatively more benign form of PV, ET and IMF with lesser frequency of symptoms, good response to treatment and less likelihood of transformation to MF, MDS or AML. (author)

  9. Cerebellar liponeurocytoma: a newly recognized clinico-pathological entity Liponeurocitoma cerebelar: uma nova entidade clínico-patológica

    Directory of Open Access Journals (Sweden)

    Nádia Montagna

    2002-09-01

    Full Text Available The term "cerebellar liponeurocytoma", recently adopted by the World Health Organization Working Group (WHO, replaced many other different terms used up to now to give name to this rare tumor. To our knowledge, less than 20 cases have been related up to now under different names like as "lipomatous medulloblastoma, lipidized medulloblastoma, neurolipocytoma, medullocytoma and lipomatous glioneurocytoma". The new nomenclature eliminates the word "medulloblastoma", reinforces its benign caracter, and includes it in the category of glioneuronal tumors. We describe an adictional case of this distinct clinico-pathological entity removed from the right cerebellar hemisphere of a 53-year-old woman. With the present case report, we hope to contribute to the knowledge on the diagnostic and prognostic implications derived from the finding of mature adipose-like tissue within a medulloblastomatous tumour.O termo "liponeurocitoma cerebelar" recentemente adotado pela Organização Mundial de Saúde (Classificação de Tumores Cerebrais - versão 2000, surgiu em substituição a vários outros utilizados até então, para denominar esta rara neoplasia. De nosso conhecimento há na literatura menos de 20 casos relatados sob termos diferentes tais como "meduloblastoma lipomatoso, meduloblastoma lipidizado, neurolipocitoma, medulocitoma e glioneurocitoma lipomatoso". A nova nomenclatura elimina a palavra "meduloblastoma", enfatiza seu caráter benigno e o coloca na categoria dos tumores glioneuronais. Descrevemos mais um caso desta rara entidade clínico-patológica, ressecada do hemisfério cerebelar direito em uma mulher de 53 anos. Com este caso esperamos contribuir para o melhor conhecimento sobre o diagnóstico, prognóstico e possibilidades terapêuticas advindas da presença de tecido adiposo em tumor meduloblastomatoso de adultos.

  10. Validation of the prognostic gene portfolio, ClinicoMolecular Triad Classification, using an independent prospective breast cancer cohort and external patient populations.

    Science.gov (United States)

    Wang, Dong-Yu; Done, Susan J; Mc Cready, David R; Leong, Wey L

    2014-07-04

    Using genome-wide expression profiles of a prospective training cohort of breast cancer patients, ClinicoMolecular Triad Classification (CMTC) was recently developed to classify breast cancers into three clinically relevant groups to aid treatment decisions. CMTC was found to be both prognostic and predictive in a large external breast cancer cohort in that study. This study serves to validate the reproducibility of CMTC and its prognostic value using independent patient cohorts. An independent internal cohort (n = 284) and a new external cohort (n = 2,181) were used to validate the association of CMTC between clinicopathological factors, 12 known gene signatures, two molecular subtype classifiers, and 19 oncogenic signalling pathway activities, and to reproduce the abilities of CMTC to predict clinical outcomes of breast cancer. In addition, we also updated the outcome data of the original training cohort (n = 147). The original training cohort reached a statistically significant difference (p value of the triad classification was reproduced in the second independent internal cohort and the new external validation cohort. CMTC achieved even higher prognostic significance when all available patients were analyzed (n = 4,851). Oncogenic pathways Myc, E2F1, Ras and β-catenin were again implicated in the high-risk groups. Both prospective internal cohorts and the independent external cohorts reproduced the triad classification of CMTC and its prognostic significance. CMTC is an independent prognostic predictor, and it outperformed 12 other known prognostic gene signatures, molecular subtype classifications, and all other standard prognostic clinicopathological factors. Our results support further development of CMTC portfolio into a guide for personalized breast cancer treatments.

  11. Clinico-radiological profile and outcome of dengue patients with central nervous system manifestations: A case series in an Eastern India tertiary care hospital

    Directory of Open Access Journals (Sweden)

    Souren Pal

    2016-01-01

    Full Text Available Background and Objective: Dengue, an acute viral disease, transmitted by Aedes mosquitoes, has a variable clinical spectrum ranging from asymptomatic infection to life-threatening dengue hemorrhagic fever and dengue shock syndrome. However, neurological complications, in general, are unusual but have been observed more frequently in the recent past, and some studies highlighted varied neurological complications during the course of illness. Although dengue is classically considered a nonneurotropic virus, there is increasing evidence for dengue viral neurotropism. In this study, we have evaluated clinico-radiological profile and outcome of nine serologically confirmed dengue patients having varied manifestations of central nervous system (CNS involvement. Materials and Methods: All the consecutive patients presented with neurological complications with positive serology for dengue infection (IgM positivity in Department of Medicine, in a tertiary care hospital in Eastern India from August 2013 to October 2014 were included in the study. These patients were subjected to a detailed clinical evaluation, laboratory assessment including complete hemogram, coagulation profile, liver function test, serum electrolytes, and routine CSF (Cerebrospinal Fluid study with the exclusion of other common neuroinvasive pathogens. Results: Out of 9 patients with neurological complications associated with confirmed dengue infection, 2 (22% patients had dengue encephalopathy, 5 (56% patients have dengue encephalitis, 1 (11% patient had dengue meningitis, and 1 (11% patient had postdengue immune-mediated CNS involvement. Conclusion: This case series reaffirms the occurrence of varied CNS manifestations in dengue virus infection and underlines the importance of inclusion of dengue in the differential diagnosis of acute encephalitis syndrome.

  12. Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Cass, Jamaica D. [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Varma, Sonal [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Day, Andrew G. [Kingston General Hospital, Kingston K7L 2V7 (Canada); Sangrar, Waheed [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Rajput, Ashish B. [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Raptis, Leda H.; Squire, Jeremy [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Madarnas, Yolanda [Department of Oncology, Queen’s University, Kingston K7L 3N6 (Canada); SenGupta, Sandip K. [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Elliott, Bruce E., E-mail: elliottb@queensu.ca [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada)

    2012-07-18

    There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a tissue microarray (TMA) of 63 human breast cancer cases, and correlates these markers with clinico-pathological data. TMA slides were scanned into an Ariol Imaging System, and histologic (H) scores (% positive tumor area x staining intensity 0–3) were calculated using trained algorithms. H scores for all five biomarkers concurred with pathologists’ scores, based on Pearson correlation coefficients (0.80–0.90) for continuous data and Kappa statistics (0.55–0.92) for positive vs. negative stain. Using continuous data, significant association of pERK expression with absence of LVI (p = 0.005) and lymph node negativity (p = 0.002) was observed. p53 over-expression, characteristic of dysfunctional p53 in cancer, and Ki67 were associated with high grade (p = 0.032 and 0.0007, respectively). Cyclin D1 correlated inversely with ER/PR/HER2-ve (triple negative) tumors (p = 0.0002). Thus automated quantitation of immunostaining concurs with pathologists’ scoring, and provides meaningful associations with clinico-pathological data.

  13. Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics

    International Nuclear Information System (INIS)

    Cass, Jamaica D.; Varma, Sonal; Day, Andrew G.; Sangrar, Waheed; Rajput, Ashish B.; Raptis, Leda H.; Squire, Jeremy; Madarnas, Yolanda; SenGupta, Sandip K.; Elliott, Bruce E.

    2012-01-01

    There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a tissue microarray (TMA) of 63 human breast cancer cases, and correlates these markers with clinico-pathological data. TMA slides were scanned into an Ariol Imaging System, and histologic (H) scores (% positive tumor area x staining intensity 0–3) were calculated using trained algorithms. H scores for all five biomarkers concurred with pathologists’ scores, based on Pearson correlation coefficients (0.80–0.90) for continuous data and Kappa statistics (0.55–0.92) for positive vs. negative stain. Using continuous data, significant association of pERK expression with absence of LVI (p = 0.005) and lymph node negativity (p = 0.002) was observed. p53 over-expression, characteristic of dysfunctional p53 in cancer, and Ki67 were associated with high grade (p = 0.032 and 0.0007, respectively). Cyclin D1 correlated inversely with ER/PR/HER2-ve (triple negative) tumors (p = 0.0002). Thus automated quantitation of immunostaining concurs with pathologists’ scoring, and provides meaningful associations with clinico-pathological data

  14. Broca's aphemia: an illustrated account of its clinico-anatomic validity Afemia de Broca: um relato ilustrado sobre sua validade anátomo-clínica

    Directory of Open Access Journals (Sweden)

    Ricardo de Oliveira-Souza

    2007-12-01

    Full Text Available OBJECTIVE: To present the case of a 54-year-old man with loss of speech, but with preservation of voluntary facio-lingual motility, language and other cognitive abilities (Broca's aphemia. METHOD: Observation of patient oral communicative abilities and general behavior, neuropsychological assessment and cranial computed tomography. RESULTS: Computed tomography showed a hyperdense lesion in the subcortex of the left precentral gyrus corresponding to Brodmann's area 6 and 44. Neuropsychological assessment confirmed that the major cognitive domains were intact. CONCLUSION: Our patient reiterates the validity of Broca's aphemia as a clinico-anatomic entity allowing us to portray it for the first time in pictures. From a neurobehavioral perspective, aphemia is related to apraxia rather than to aphasia, a fact that may have hampered the full grasp of its far-reaching implications for neurology and aphasiology.OBJETIVO: Apresentar o caso de um paciente de 54 anos de idade com perda da fala, mas preservação da linguagem, das demais capacidades cognitivas, e da motilidade fácio-lingual voluntária (afemia de Broca. MÉTODO: Observação da capacidade de comunicação oral e do comportamento geral, exame neuropsicológico e tomografia computadorizada do crânio. RESULTADOS: A tomografia computadorizada revelou lesão hiperdensa no subcórtex do giro precentral esquerdo correspondendo às áreas 6 e 44 de Brodmann. O exame neuropsicológico confirmou que os principais domínios cognitivos se encontravam intactos. CONCLUSÃO: Nosso paciente reiterou a validade da afemia de Broca como entidade anátomo-clínico permitindo documentá-la em fotos pela primeira vez. Da perspectiva neurocomportamental, a afemia está vinculada às apraxias e não às afasias, o que pode ter prejudicado a apreensão plena do seu profundo significado para a neurologia e para a afasiologia.

  15. Recent outbreak of cutaneous anthrax in Bangladesh: clinico-demographic profile and treatment outcome of cases attended at Rajshahi Medical College Hospital

    Directory of Open Access Journals (Sweden)

    Siddiqui Muhammad

    2012-08-01

    Full Text Available Abstract Background Human cutaneous anthrax results from skin exposure to B. anthracis, primarily due to occupational exposure. Bangladesh has experienced a number of outbreaks of cutaneous anthrax in recent years. The last episode occurred from April to August, 2011 and created mass havoc due to its dreadful clinical outcome and socio-cultural consequences. We report here the clinico-demographic profile and treatment outcome of 15 cutaneous anthrax cases attended at the Dermatology Outpatient Department of Rajshahi Medical College Hospital, Bangladesh between April and August, 2011 with an aim to create awareness for early case detection and management. Findings Anthrax was suspected primarily based on cutaneous manifestations of typical non-tender ulcer with black eschar, with or without oedema, and a history of butchering, or dressing/washing of cattle/goat or their meat. Diagnosis was established by demonstration of large gram-positive rods, typically resembling B. anthracis under light microscope where possible and also by ascertaining therapeutic success. The mean age of cases was 21.4 years (ranging from 3 to 46 years, 7 (46.7% being males and 8 (53.3% females. The majority of cases were from lower middle socioeconomic status. Types of exposures included butchering (20%, contact with raw meat (46.7%, and live animals (33.3%. Malignant pustule was present in upper extremity, both extremities, face, and trunk at frequencies of 11 (73.3%, 2 (13.3%, 1 (6.7% and 1 (6.7% respectively. Eight (53.3% patients presented with fever, 7 (46.7% had localized oedema and 5 (33.3% had regional lymphadenopathy. Anthrax was confirmed in 13 (86.7% cases by demonstration of gram-positive rods. All cases were cured with 2 months oral ciprofloxacin combined with flucoxacillin for 2 weeks. Conclusions We present the findings from this series of cases to reinforce the criteria for clinical diagnosis and to urge prompt therapeutic measures to treat

  16. STUDY OF CLINICO- EPIDEMIOLOGICAL PROFILE OF PATIENTS ADMITTED WITH INFANTILE TREMOR SYNDROME (ITS AND STATUS OF TRACE ELEMENTS (ZINC, COPPER DEFICIENCY IN THEM

    Directory of Open Access Journals (Sweden)

    Mohan Makwana

    2017-03-01

    Full Text Available BACKGROUND Under nutrition is one of the major problems in the field of Paediatrics. The greatest risk of malnutrition is in the first two years of life. The effects of this early damage on health, brain development, intelligence, educability and productivity are potentially reversible. The current study was an attempt to find out the clinico epidemiological profile, evaluate them for trace elements deficiency and most appropriate management options in those who are admitted with infantile tremor syndrome. MATERIALS AND METHODS The current study was a hospital based cross sectional study that was conducted in the Department of Paediatrics, Dr. S. N. Medical College Jodhpur. Duration of study was One Year. Any child up to the age of three years of age admitted in the paediatric wards with typical features of infantile tremor syndrome. RESULTS Maximum numbers of patients were found between 6 months to 12 months of age, there was slight male predominance. The majority of infants in our study (85% were exclusively breast fed, 66% of cases were having low serum Copper level. 9% of cases were having low serum zinc level. 8% of cases were having low serum copper level with tremors. CONCLUSION In our study the fact that NTS is mainly seen in children who are exclusively breast feed for a longer period with delayed introduction of weaning foods. The main presenting features remain developmental delay, hyper pigmentation and anemia. Among nutritional factors, deficiency of copper and zinc in children plays a big role in development of disease. Thus to prevent the development of nutritional tremor syndrome stress should be on early timely introduction of weaning foods, especially rich in copper and zinc. What is already known about this Study- low levels of trace elements like copper and zinc may be responsible for typical clinical manifestations in patients of infantile tremor syndrome. Pronged and Exclusive breast feeding further aggravate these features

  17. Enfermedad de Hodgkin: nuevos conceptos clínico-patológicos Hodgkin´s disease: new clinico-pathologic features

    Directory of Open Access Journals (Sweden)

    José René Mesa Cuervo

    2000-04-01

    Full Text Available La enfermedad de Hodgkin, considerada una neoplasia linfoide, se clasifica en 5 grupos a partir de la conferencia de Rye en 1966. La variedad esclerosis nodular es la más frecuente, afecta generalmente regiones supradiafragmáticas y se divide en 2 grados, con características morfológicas y pronósticas diferentes. El grado II, de mal pronóstico, exige formas de tratamiento más agresivas. La celularidad mixta suele tener mayor diseminación de la enfermedad y junto a la esclerosis nodular, se catalogan como formas clásicas de la enfermedad, con positividad para los marcadores inmunofenotípicos CD15 y CD30. El predominio linfocítico se considera un linfoma de células del centro germinal y emerge como entidad clínicopatológica diferente. La depleción linfocítica se diagnostica con baja frecuencia y tiene un pronóstico desfavorable. El diagnóstico diferencial con linfomas no hodgkinianos no siempre es posible y actualmente se señala que la delimitación entre ambos tipos de linfomas no está bien definida. El grupo no clasificado tiende a desaparecerHodgkin´s disease, considered a lymphoid neoplasia, is classified in 5 groups, since Rye Conference in 1960. Nodular sclerosis variety is commonest, generally involve supradiaphragmatic regions and is divided in two grades with distinct morphologic ant prognostic features. Grade II of badly prognosis demand a more aggresive treatment. Mixed cellularity ussualy has a greater disease spreading level and joined with nodular sclerosis, are classified as classic forms of disease, positive to immunophenotypical markers, CD15 and CD30. Lymphocytic predominance is to be considered as a cell lymphoma of germinal center and emerge as a distinct clinico-pathologic entity with a unfavourable prognosis. Differential diagnosis in non-Hodgkin´s lymphomas, unusually is possible and at present, delimitation between both types of lymphoma, es not well defined. Non classified group have a tendency to

  18. Genetic Counselling, BRCA1/2 Status and Clinico-pathologic Characteristics of Patients with Ovarian Cancer before 50 Years of Age

    Science.gov (United States)

    Cvelbar, Mirjam; Hocevar, Marko; Novakovic, Srdjan; Stegel, Vida; Perhavec, Andraz

    2017-01-01

    Abstract Background In Slovenia like in other countries, till recently, personal history of epithelial ovarian cancer (EOC) has not been included among indications for genetic counselling. Recent studies reported up to 17% rate of germinal BRCA1/2 mutation (gBRCA1/2m) within the age group under 50 years at diagnosis. The original aim of this study was to invite to the genetic counselling still living patients with EOC under 45 years, to offer gBRCA1/2m testing and to perform analysis of gBRCA1/2m rate and of clinico-pathologic characteristics. Later, we added also the data of previously genetically tested patients with EOC aged 45 to 49 years. Patients and methods All clinical data have to be interpreted in the light of many changes happened in the field of EOC just in the last few years: new hystology stage classification (FIGO), new hystology types and differentiation grades classification, new therapeutic possibilities (PARP inhibitors available, also in Slovenia) and new guidelines for genetic counselling of EOC patients (National Comprehensive Cancer Network, NCCN), together with next-generation sequencing possibilities. Results Compliance rate at the invitation was 43.1%. In the group of 27 invited or previously tested patients with EOC diagnosed before the age of 45 years, five gBRCA1/2 mutations were found. The gBRCA1/2m detection rate within the group was 18.5%. There were 4 gBRCA1 and 1 gBRCA2 mutations detected. In the extended group of 42 tested patients with EOC diagnosed before the age of 50 years, 14 gBRCA1/2 mutations were found. The gBRCA1/2m detection rate within this extended, partially selected group was 33.3%. There were 11 gBRCA1 and 3 gBRCA2 mutations detected. Conclusions The rate of gBRCA1/2 mutation in tested unselected EOC patients under the age of 50 years was higher than 10%, namely 18.5%. Considering also a direct therapeuthic benefit of PARP inhibitors for BRCA positive patients, there is a double reason to offer genetic testing to

  19. [Quality control at the Istituto di Anatomia e Istologia patologica at the Università di Bologna].

    Science.gov (United States)

    Alampi, G; Baroni, R; Berti, E; Ceccarelli, C; Dina, R; Eusebi, V; Giangaspero, F; Grigioni, F W; Lecce, S; Losi, L

    1994-04-01

    The growing importance in medical practice of a standardized diagnosis in cyto- and histopathology and the recent recommendations for the adoption of standardized schemes for quality control in anatomic pathology by International Committees stimulated the medical staff of the Institute of Anatomic Pathology of the University of Bologna to adopt a pertinent method. The method used by the Department of Pathology of the Yale University (New Haven, Connecticut, USA) was chosen. A Committee for the quality control was appointed and two kinds of controls were set up: an External Quality Assessment (review of the difficult cases by external experts, slide seminars) and an Internal Quality Assessment performed by the members of the Committee on the diagnostic and laboratory routine of the Institute. Such a survey is periodically monitored during the monthly meetings of the Committee and described in the monthly reports. The present paper illustrates the method adopted and the preliminary results obtained in order to stimulate the discussion of such a critical theme in contemporary Anatomic Pathology at a national level.

  20. Controversies on Hodgkin's disease and anaplastic large cell lymphoma. Hematopathology Study Group of the Società Italiana di Anatomia Patologica.

    Science.gov (United States)

    Pileri, S

    1994-01-01

    Just one year ago the Italian Society of Pathology (S.I.A.P.) created a Study Group which included members of the most active Italian hematopathology teams. Prof. Pasquale Calapso was asked to chair the Group and Prof. Stefano Pileri to take care of secretarial duties. The aim of the Group is to spread hematopathologic knowledge among young pathologists and to promote activities that can contribute to updating Italian pathologists on topics of both speculative and diagnostic interest. The first Workshop of the S.I.A.P. Hematopathology Group was held at the Palazzo dei Congressi in Bologna, November 20, 1993. About 150 pathologists from all over Italy took part in the meeting, which consisted of two sections devoted to: a) discussion of the boundaries between Hodgkin's disease and non-Hodgkin's lymphomas, and b) a case seminar illustrating the impact of immunohistochemistry in the diagnosis of bone-marrow biopsy. The first section included 5 presentations and a Round Table chaired by Prof. Luciano Fiore-Donati. Below, the contributors to this section summarize the content of their presentations, which were aimed at answering specific questions the Organizers had put to them.

  1. O aprendizado da construção decaso clínico em saúde mental El aprendizaje de la construccion del caso clinico en salud mental Learning to construct a clinical case in mental health

    Directory of Open Access Journals (Sweden)

    Aline Maino Pergola

    2008-06-01

    Full Text Available Este estudo objetivou relatar a experiencia de uma aluna na construção de caso clinico em Saude Mental, desenvolvida nas disciplinas de Enfermagem em Saude Mental II e Enfermagem Psiquiátrica da Graduação em Enfermagem (Unicamp. Para estas disciplinas, a construção de caso é entendida como a articulação entre a entrevista psiquiátrica e alguns conceitos da teoria psicanalítica, aprendidos nas aulas, supervisao e leitura de textos, pretendendo estruturar um cuidado de Enfermagem coerente com a concepção de homem do referencial psicanalítico: um sujeito dividido pela existência do inconsciente, estruturado como linguagem. O relato baseou-se na experiência vivida pela aluna, durante as disciplinas, na produção de relatórios e construção de caso sob a forma de trabalho final. Foi possivel a aluna desenvolver a leitura do caso e construir uma teoria sustentadora do atendimento, por meio das demandas levantadas no diálogo com o paciente que direcionaram os pontos passíveis de intervenção.En este estudio se tuvo como objetivo relatar la experiencia de una alumna en la construcción del caso clínico en Salud Mental, desarrollada en las disciplinas de Enfermería en Salud Mental II y Enfermería Psiquiátrica del Pregrado en Enfermería (Unicamp. Para estas disciplinas, la construcción del caso es entendida como la articulación entre la entrevista psiquiátrica y algunos conceptos de la teoría psicoanalítica, aprendidos en las clases, supervisión y lectura de textos, pretendiendo estructurar un cuidado de Enfermería coherente con la concepción de hombre del referencial psicoanalítico: un sujeto dividido por la existencia del inconsciente, estructurado como lenguaje. El relato se basó en la experiencia vivida por la alumna, durante las disciplinas, en la producción de informes y construcción del caso bajo la forma de un trabajo final. Fue posible que la alumna desarrolle la lectura del caso y construir una teor

  2. Clinico epidemiological study of pitted keratolysis

    Directory of Open Access Journals (Sweden)

    Naik Chandra

    2007-01-01

    Full Text Available Background: Pitted keratolysis is a common dermatological condition. However, very few studies are available on the clinical characteristics and epidemiological features of this disorder from India and abroad. Materials and Methods: Fifty patients from rural area of Kolar at Sri R.L.J.H. and S.N.R. Hospital, presenting with clinically distinctive lesions of pitted keratolysis were included in the study. Cases were interviewed with particular emphasis on triggering factors and findings were recorded. Investigations like Gram′s stain, culture studies, Wood′s ultraviolet light examination, histopathology etc, was done in selected cases to ascertain the clinical diagnosis. Results: Age of the patients varied from 20 to 40 years in 52% with male preponderance in 82% of cases. Duration of the disease varied from 15 days to five years, most of the patients were bare-footed farmers (62% of cases. Hyperhidrosis and pruritus were most frequently observed symptoms in 70% and 60% of patients. Most of the patients presented with the characteristic pits which varied from 1 to 50 in number in 56 % of cases, located predominantly on the pressure bearing areas in 92% of cases and depth of the pits varied from 1 to 2 mm in 60% of cases. Associated skin conditions recorded in present study were fissuring of soles in 38%, psoriasis 10%, dermatophyte infections in 6%, planter warts 6% and Corynebacterial triad and corn in 2% of patients each. Discussion: Affection of bare-footed individuals, male preponderance, presence of hyperhidrosis and occurrence of lesions over pressure bearing areas of soles, observed in the present study were consistent with earlier studies on the subject. However, pruritus as commonest presenting symptom reported by 60% patients in the present study, has not been documented in the previous studies. Conclusion: Pitted keratolysis is fairly common in bare footed male farmers of rural India. The condition is predominantly seen over the pressure bearing areas of sole and hyperhidrosis is common precipitating factor. Pruritus, a common presenting symptom observed in this study has not been reported earlier.

  3. Pancytopenia: A clinico-hematological study

    Directory of Open Access Journals (Sweden)

    Fahim Manzoor

    2014-01-01

    Full Text Available Background: A review of both Western and Indian literature shows that there are few comprehensive studies on pancytopenia. In India, the causes of pancytopenia are not well defined. This data, if available, would help in planning the diagnostic and therapeutic approach in patients with pancytopenia. Aim: To evaluate the cases of pancytopenia by peripheral smear and/or bone marrow aspiration and/or bone marrow biopsy to find out the etiology, clinical, hematological, and histomorphologic features of pancytopenia. Materials and Methods: Detailed hematological investigations a complete hemogram, peripheral smear examination, bone marrow aspiration, and biopsy examination were done. Results: The most common cause of pancytopenia in our study was megaloblastic anemia (56%, followed by hypoplastic/aplastic anemia (14%, hypersplenism (8% and post viral illness (6%. Conclusion: Megaloblastic anemia due to vitamin B12/folate deficiency seems to reflect the higher prevalence of pancytopenia in Indian subjects, putting hypoplastic/aplastic anemia in the second position, which is the leading cause for pancytopenia in the Western countries.

  4. CYSTIC AMELOBLASTOMA: A CLINICO-PATHOLOGIC REVIEW

    African Journals Online (AJOL)

    a tertiary health care centre. Materials: All cases diagnosed as cystic ameloblastoma in the ..... Unicystic amelobla- stoma. A prognostically distinct entity. Cancer. 1977;40: 2278-2285. 4. Ackermann GL, Altini M, Shear M: The unicystic ameloblastoma: A clinicopathologic study of 57 cases. J Oral Pathol. 1988;17: 541-546. 5.

  5. Clinico-Pathologic Presentation and Management of ...

    African Journals Online (AJOL)

    Von Recklinghausen's) Disease among North-Eastern Nigerians: A six year review. ... presentation and to highlight the need of multi disciplinary approach in the management of this condition. Methodology: The case records of patients who ...

  6. Disordered eating attitudes: demographic and clinico ...

    African Journals Online (AJOL)

    Department of Psychiatry, Lagos University Teaching Hospital, PMB12003, ... attitudes among undergraduate students of two higher institutions in Lagos, Nigeria. .... as a profile of the eating attitudes of the sub-scale scores ..... lar studies conducted in Iran, Brazil and Canada where ..... Educational Research and Evaluation.

  7. Neonatal mastitis: a clinico-microbiological study.

    Science.gov (United States)

    Masoodi, Talat; Mufti, Gowhar Nazir; Bhat, Javeed Iqbal; Lone, Rubina; Arshi, Syed; Ahmad, Syed Khurshid

    2014-01-01

    Neonatal breast hypertrophy is a common phenomenon in term infants, superadded infection can lead to mastitis and that can progress to breast abscess with short and long term detrimental effects. Our effort is to study the prevalence, risk factors, the current microbial profile and sensitivity pattern in these infections in order to suggest an optimal treatment plan for these patients. Case series. Hospital based study conducted in Kashmir on the native population. 2011 to 2013. 32 neonates with features of mastitis or abscess were included in the study. Demographic and clinical data, laboratory work-up were recorded for all these patients in a patient form. Gram stain of the purulent nipple discharge or pus obtained on drainage was done and the specimens were culture plated. Antibiotic sensitivity was determined by disk diffusion and categorized by current Clinical and Laboratory Standards Institute (CLSI) guidelines. Most babies were full term, the age range was 6-48 days. Peak incidence for mastitis was in the 2nd week and for abscess in the 4th week. The ratio of male: female was 1:2 in the entire group, there was greater preponderance of female involvement with increasing age. Massage for expression of secretions a common practice in the study population had been done in 15 patients, especially in male babies. The babies were generally well and associated skin pustulosis was common. Laboratory workup showed polymorphonuclear leucocytosis and CRP positivity. Gram staining showed gram positive cocci in 13 patients and gram negative rods in 1 patient. Culture revealed Staphylococcus aureus in 18, E.col in 2, klebsiella in 1 patient and was sterile in 2 patients. Most strains of Staphylococcus aureus were resistant to macrolides and penicillins. Fifteen were methicillin sensitive and 3 were resistant but were sensitive to amikacin, ofloxacin and vancomycin. Gram negative rods were sensitive to, aminoglycosides, chloramphenicol, quinolones, piperacillin-tazobactum and cefoperazone-sulbactum, but were resistant to cephalosporins including third generation cephalosporins. Treatment with oral antibiotic was not successful. Patients responded well to open drainage via a stab incision away from the breast mound; 4 patients were managed by repeated needle aspirations. IV antibiotics were prescribed in all patients for 2-5 days, followed by oral continuation therapy of 7-14 days. From our study, we can conclude that parental counseling to avoid massage, and early treatment for pustulosis is important to prevent mastitis. Intravenous antibiotics should be used for this condition guided by gram stain or culture sensitivity once available. Empirically a drug with good anti-staph cover may be instituted till appropriate reports are available. Incision drainage gives uniformly good results, though; multiple sittings of needle drainage may obviate the need for incision drainage. Therapy can be shifted to oral drugs once clinical improvement is seen.

  8. Clinico Mycological Study of Superficial Mycoses

    Directory of Open Access Journals (Sweden)

    Rachana J. Magdum

    2016-10-01

    Full Text Available Background: Generally it is well established fact that geographical distribution of the fungi may change from time to time; hence this study was planned. Aim and Objectives: To analyze the prevalence of superficial mycoses, its clinical presentation and species identification of the fungal isolates responsible for the disease. Material and Methods: A total 125 clinically diagnosed cases of superficial mycoses visiting Dermatology and Venereology outpatient department of Bharati Hospital, Sangli, for a period of one year were included in the study. Specimens like skin scrapping, nail clipping, hair were collected and subjected to KOH mount and culture. Identification of species was done by macroscopic examination of culture, tease mount and other physiological tests including Urease test, Hair perforation tests and Germ tube test. Results: Superficial mycosis was more common in the age group of 21-30 years (28% and in males (60.8%. The infection was more common in students (29.6%. Tinea corporis (42.4% was the commonest clinical type followed by tinea cruris (22.4%. 61.6% cases were positive by direct microscopy and 60.8% cases showed culture positive. Out of 125 samples, dermatophytes were grown in 63 cases (82.89% followed by non dermatophytic moulds in 10 cases (13.16% and Candida albicans in 3 cases (3.95%. The most common isolate among dermtophytosis was T. rubrum (46.05% followed by T. mentagrophyte (25%. Conclusion: It was concluded that along with dermatophytes, non dermatophytic moulds are also important to cause of superficial mycoses

  9. A CLINICO PATHOLOGICAL STUDY OF CERVICAL LYMPHADENOPATHY

    Directory of Open Access Journals (Sweden)

    Shaik Ahmed Sheriff

    2017-10-01

    Full Text Available BACKGROUND Cervical lymphadenopathy is a common finding in day today surgical practice which poses a challenge to the clinician because clinical findings may not always help in arriving at a possible cause. Meticulous history taking and thorough clinical examination most of the times helps the clinician in diagnosis but for confirmation and planning management histological examination always helps. Fine Needle Aspiration Cytology is emerging as a first line diagnostic tool in evaluating lymphadenopathy. The aim of this study was to identify various causes of cervical lymphadenopathy and to identify the distribution in various age groups and to compare clinical findings with pathological findings. This is a prospective study on Cervical Lymphadenopathy conducted on 130 patients in Department of General Surgery at Sri Venkateswara Ramnarain Ruia Government General Hospital, Tirupati from September 2015 to October 2016. MATERIALS AND METHODS This was a prospective study conducted in department of general surgery in Sri Venkateswara Ramnarain Ruia Government General Hospital, Tirupati from September 2015 to October 2016. A total of 130 patients were included in the study. Detailed history was taken and clinical examination was done, required investigations were done, Fine Needle Aspiration Cytology was done in all the cases. Results were analysed. RESULTS Tuberculosis was the most common cause (42% followed by non-specific lymphadenitis (25%. Women were more affected than men. Young adults in 18-30 years age group were more affected by TB whereas patients in age group 51-60 were affected with malignancy. Fine Needle Aspiration Cytology was conclusive in 125 cases. CONCLUSION Tuberculosis is the most common cause followed by non-specific lymphadenitis, metastatic lymph nodes. Fine Needle Aspiration Cytology is simple, quick and cheap investigative tool in cervical lymphadenitis evaluation.

  10. [Clinico-pathogenetic variants of chronic gastritis].

    Science.gov (United States)

    Chernin, V V; Dzhulaĭ, G S

    2004-01-01

    To evaluate specific features of the course of chronic gastritis (CG), morphofunctional condition of gastric mucosa, vegetative regulation, adrenergic and cholinergic shifts, histamine metabolism and effects of exogenic and endogenic risk factors in CG patients; to study clinicopathogenetic variants of CG. A total of 311 CG patients aged from 16 to 72 years were studied. They were divided into three groups by their gastric mucosa condition. The control group consisted of 30 healthy donors. The following parameters were studied: visual and histological condition of gastric mucosa, total acidity, the levels of free hydrochloric acid, pepsin, bioelectric gastric activity, general autonomic tonicity, cholinesterase activity. Three clinicopathogenetic variants of the disease have been identified. Variant 1 was characterized by a recurrent course, subjective manifestation of the disease only in exacerbation, surface (primarily antral) mucosal affection, normal or enhanced secretory and motor functions of the stomach, adequate reaction of acid production to caffeine and histamine stimulation, parasympathicotonia, absolute hyperhistaminemia, relative hypoacetylcholinemia, subnormal urinary excretion of adrenalin. Variant 2 manifested with rare recurrences, longer and more severe exacerbations, frequent spontaneous and provoked aggravations, moderate focal atrophy of the mucosa, secretory insufficiency with adequate reaction to histamine and minor to caffeine stimuli, hypomotor gastric dyskinesia, vegetative eutonia, normohistaminemia, absolute hypoacetylcholinemia, subnormal urinary excretion of noradrenaline. Variant 3 runs without definite remissions and exacerbations, with continuous abdominal pain and dyspepsia, frequent spontaneous aggravations, marked extended mucosal atrophy with secretory insufficiency up to achlorhydria, no stimulation of acid production in response to caffeine and histamine, gastric hypomotility, sympathicotonia, absolute hypohistaminemia, hypoacetylcholinemia, normal urinary excretion of catecholamines. The findings expand our knowledge about clinicopathogenetic variants of CG and necessitate new approaches to development of effective methods of CG prevention and treatment.

  11. Childhood AIDS: pulmonary involvement. Clinico radiological correlation

    International Nuclear Information System (INIS)

    Cinta, C.; Muro, D.; Perez, A.; Otero, M.C.

    1997-01-01

    To determine the different radiological findings in the lung of children presenting human ummunodeficiency virus (HIV) infection. We assess the different radiological patterns and their prevalence. The study deals with 58 children presenting HIV infection. All underwent plain chest radiography at some time during the course of their disease to determine the cause of different respiratory symptoms (dyspnea, fever, cough, etc.).Bronchial lavage was performed in all the children who required intubation due to severe respiratory distress. The results of chest X-ray were normal in 29 children despite the existence of pulmonary symptomatology. The other 29 patients presented pulmonary, including 21 cases of pneumonia (36,2%) in 16 patients, in seven of whom the pathogen was determined by blood culture. Four cases of Pneumocystis carinii (6.89%) were diagnosed by means of bronchial lavage. There were nine children with interstitial pneumonitis, five of the lym-phoid variant (8.62%) and four of unknown origin (6.89%). In contrast to the findings in adults, we have had no cases of pulmonary tuberculosis among our patients The rates of morbidity and mortality among HIV-infected children are associated with lung involvement. However, the prevalence has decreased progressively since the introduction of antiviral agents. Recurrent bacterial pneumonia and opportunistic Pneumocystis carinii infection are the most common types of acute pulmonary involvement. Interstitial pneumonitis usually develops a chronic course. (Author) 15 refs

  12. Receptor Status and Associated Clinico- Histopathological ...

    African Journals Online (AJOL)

    Key Words: Breast cancer, Advanced stage,. Hormonal ..... A woman's risk of breast cancer is higher if her first degree ... are consistent with the emerging picture of breast ... duration of onset of symptoms is subject to recall bias and may not ...

  13. Clinico - demographic factors associated with diarrhoeal disease ...

    African Journals Online (AJOL)

    Objectives: To determine the proportion of under-5 children presenting with diarrhoeal disease, and the clinicodemographic variables associated with the outcome at the emergency paediatric ward (CHER) of the Nnamdi Azikiwe University Teaching Hospital, Nnewi, South- East Nigeria. Methods: Clinical and demographic ...

  14. Schistosoma liver disease; a clinico- pathological study

    International Nuclear Information System (INIS)

    Ali, Suzan Ibrahim

    1996-05-01

    Schistomiasis mansoni infection is a leading cause of severe morbidity in the Sudan. Most of the morbidity and mortality are due to the development of hepatic periportal fibrosis and consequent portal hypertension and bleeding varices. This is a hospital-based, retro-prospective study in the period from 1980-1995. Liver disease (i.e. periportal fibrosis) and its clinical presentation were studied in relation to the degree of fibrosis and other pathological, haematological, and biochemical parameters. The study identified the common hospital presenting symptoms, assessed factors that influence pathogenesis of periportal fibrosis and its severity, as well as, defined criteria which predict those patients who are at risk of bleeding. 898 patients were included. The common presenting symptoms were left hypochondrial pain, haematemesis and enlarged spleen (Towal). Males were found to have an increase prevalence of periportal fibrosis. Splenomegaly was found in almost all patients of the study of different age groups, but spleen size didn't show any significant difference between bleeders and non-bleeders (p=0.28). A sharp rise in the prevalence of bleeding was noted after the age of 16 years. Upper gastrointestinal bleeding was found to be more common

  15. Clinico-Histologic Conferences: Histology and Disease

    Science.gov (United States)

    Shaw, Phyllis A.; Friedman, Erica S.

    2012-01-01

    Providing a context for learning information and requiring learners to teach specific content has been demonstrated to enhance knowledge retention. To enhance students' appreciation of the role of science and specifically histology in clinical reasoning, disease diagnosis, and treatment, a new teaching format was created to provide clinical…

  16. Radiologic evaluation of facial injury; Avaliacao radiologica dos traumatismos faciais

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Ricardo Pires de; Volpato, Richard [Complexo Hospitalar Heliopolis, Sao Paulo, SP (Brazil). Servico de Diagnostico por Imagem]. E-mail: richard_volpato@uol.com.br; Nascimento, Lia Paula [Complexo Hospitalar Heliopolis, Sao Paulo, SP (Brazil)

    2003-03-01

    A detailed radiological investigation of the maxillofacial injuries is essential to achieve good treatment results. The images should identify every lesion and guide the treatment, thus improving esthetic and functional results. With the aim of simplifying the diagnostic task, the face may be seen as a five regions structure that may suffer a regional fracture or combined fractures involving the adjacent regions. These regions represent areas of focus for pre surgical planning and are as follows: nasal, orbital, zygomatic, maxillary, and mandibular. In order to understand the injury mechanisms and their consequences it is useful to know the supporting buttresses, which are divided in five sagittal planes, three horizontal planes and two coronal planes. We reviewed the cases of patients with facial trauma treated at Complexo Hospitalar Heliopolis, Sao Paulo, Brazil. A review of the relevant issues concerning radiological investigation of these injuries is presented. This study allowed standardization and ordering of the radiological investigation in patients with facial trauma. (author)

  17. Radiological monitoring in borders; Vigilancia radiologica en fronteras

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Garcia, I.

    2008-07-01

    Traditionally customs fulfilled a mission of collecting taxes levied for different purposes, one of which was to protect national industries. In recent years, and considering the changes that have occurred in international security, the security of the transport chain as the mainstay of trade and the need to control weapons of mass destruction have been identified as specific goals, and at the same time the need to control illegal trafficking to reduce the drug trade and contraband of counterfeit products has intensified. (Author)

  18. The male breast: radiological abnormalities; Anormalidades radiologicas da mama masculina

    Energy Technology Data Exchange (ETDEWEB)

    Maranhao, Norma; Costa, Isis; Nascimento, Raquel Cristine Gomes do [Clinica Radiologica Lucilo Maranhao, Recife, PE (Brazil)

    1998-01-01

    Mammography of male breast account for less than 1% of mammographic examinations in most breast services. Due to the low incidence of breast cancer in men the significant majority of mammographic diagnosis reveals benign diseases, mostly gynecomastia. Therefore it is most important to identify features of benign conditions, such as gynecomastia, in order to reduce the number of unnecessary surgical biopsies performed in these patients, for the same reason suspicious lesions must be recognized as well. Indications for mammography in men include evaluation of palpable mass, recent onset of breast nipple-areolar skin changes or papillary discharge, and previous history of cancer. (author) 10 refs., 12 figs.

  19. Laboratory of environmental radiological surveillance; Laboratorio de vigilancia radiologica ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Mendez G, A.; Marcial M, F.; Giber F, J.; Montiel R, E.; Leon del V, E.; Rivas C, I.; Leon G, M.V.; Lagunas G, E.; Aragon S, R.; Juarez N, A.; Alfaro L, M.M

    1991-12-15

    The department of radiological protection of the ININ requests the collaboration of the Engineering Unit for the elaboration of the work project of the laboratory of environmental radiological surveillance. The emission of radioactive substances to the atmosphere like consequence of the normal operation of the Nuclear Center, constitutes an exhibition source from the man to the radiations that it should be appropriately watched over and controlled to be able to determine the population's potential exhibition that it lives in the area of influence of the installation. (Author)

  20. External plans for radiological emergency; Plan de emergencia radiologica externo

    Energy Technology Data Exchange (ETDEWEB)

    Suarez, G; Vizuet G, J; Benitez S, J A [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    Since 1989, the National Institute of Nuclear Research in Mexico shares in the task of Food and Water Control corresponding to the FT-86 task force of External Plans for Radiological Emergency (PERE), in charge of the Veracruz Health Services. In the PERE preparation stage previous actions are necessary developed for the preparation and updating of this plan and the task organization with the purpose to maintaining standing and operable in any time and circumstance, the capability to response in the face of an emergency. This stage englobes activities which must be realized before to carry out the Plan as they are the specialized training of personnel which participates and the execution of exercises and simulacrums. Until 1998, training and exercises for this task had been realized under diverse possible sceneries but in conditions that simulated the presence of radioactive material. For this reason, it should be emphasized the training realized during the days 6th, 7th, 8th July, 1999, in the emergency planning zone of the Plan, which to carry out using radioactive material. The National Institute of Nuclear Research had in charge of the training. This work describes all the activities for the realization of this training. (Author)

  1. Laboratory of environmental radiological surveillance; Laboratorio de vigilancia radiologica ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Mendez G, A; Marcial M, F; Giber F, J; Montiel R, E; Leon del V, E; Rivas C, I; Leon G, M V; Lagunas G, E; Aragon S, R; Juarez N, A; Alfaro L, M M

    1991-12-15

    The department of radiological protection of the ININ requests the collaboration of the Engineering Unit for the elaboration of the work project of the laboratory of environmental radiological surveillance. The emission of radioactive substances to the atmosphere like consequence of the normal operation of the Nuclear Center, constitutes an exhibition source from the man to the radiations that it should be appropriately watched over and controlled to be able to determine the population's potential exhibition that it lives in the area of influence of the installation. (Author)

  2. Training in radiological protection; Capacitacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Medina G, E., E-mail: medina@ipen.gob.pe [Instituto Peruano de Energia Nuclear, Av. Canada 1470, San Borja, Lima 41 (Peru)

    2014-08-15

    In the Peru, according to the current regulations, people that work with ionizing radiations should have an authorization (individual license), which is granted by the Technical Office of the National Authority that is the technical body of the Instituto Peruano de Energia Nuclear (IPEN) manager of the control of ionizing radiations in the country. The individual license is obtained after the applicant fulfills the requested requirements, as having safety knowledge and radiological protection. Since its founding in 1972, the Centro Superior de Estudios Nucleares (CSEN) of the IPEN has carried out diverse training courses in order to that people can work in a safe way with ionizing radiations in medicine, industry and research, until the year 2013 have been organized 2231 courses that have allowed the training of 26213 people. The courses are organized according to the specific work that is carried out with radiations (medical radio-diagnostic, dental radiology, nuclear medicine, radiotherapy, industrial radiography, nuclear meters, logging while drilling, etc.). In their majority the courses are directed to people that will make use of radiations for first time, but refresher courses are also granted in the topic. The CSEN also carries out the Master degree programs highlighting the Second Professional Specialization in Radiological Protection carried out from the year 2004 with the support of the National University of Engineering. To the present has been carried out 2 programs and there is other being developed. In this work is shown the historical evolution of the radiological protection courses as well as the important thing that they are to work in a safe way in the country. (Author)

  3. Measurements and Clinical Findings on Thorotrast Deposits in the Kidney; Mesures et Observations Cliniques Faites sur des Depots de Thorotrast dans le Rein; 0418 0417 041c 0414 ; Determinaciones y Datos Clinicos Relativos a los Depositos Renales de Torotrasto

    Energy Technology Data Exchange (ETDEWEB)

    Oberhausen, E.; Muth, H.; Grillmaier, R. [Institut Fuer Biophysik der Universitaet des Saarlandes, Homburg (Saar), Federal Republic of Germany (Germany)

    1964-11-15

    thorotrast dans le rein. Il n'en faut pas moins s'attendre a trouver de nombreux malades dont les reins contiennent des depots de thorotrast car le thorotrast a ete utilise tres souvent comme substance opaque dans les pyelographies retrogrades. Dans les conditions normales, tout le thorotrast aurait du etre emporte par l'urine. Cependant, si l'application a ete faite sous forte pression ou qu'il y eut a l'epoque une infection renale, il se peut qu'une partie du thorotrast se soit deposee dans les tissus. Il est possible qu'un nombre important de ces depots ne puisse etre identifie sur les radiographies, car ils ressemblent beaucoup a des depots de calcium dans le rein et il faut une certaine experience pour distinguer les depots de calcium des depots de thorotrast. Au cours des dernieres annees, les auteurs, en collaboration avec des urologues, ont pu reperer sept cas de ce genre. Lorsqu'il n'y avait de depot que dans un seul'rein, ce qui etait le- cas chez six sujets, on a procede a l'ablation de l'organe. L'examen histol ogique a'revele cinq carcinomes ainsi'qu'une degenerescence tres poussee d'un rein. D'apres les observations des auteurs, il faut entre 20 et 25 annees pour qu'un carcinome se developpe. Dans deux cas, il a ete possible d'examiner le sujet dans l'anthropogamraametre et de doser les{sup r}adionucleides contenus dans l'urine et le thoron contenu dans l'air exhale. Ces dosages ont ete effectues avant et apres la nephrectomie. On a egalement mesure les rayons gamma emis par l'organe isole. Ces diverses mesures ont permis de proceder a une evaluation de la dose de rayonnements. (author) [Spanish] Los trabajos publicados acerca de los depositos de torotrasto en el sistema reticuloendotelial y de los datos clinicos obtenidos son bastante abundantes. En cambio, son contados los casos de depositos renales de toro- trasto descritos en la bibliografia. Sin embargo, es de suponer que hay muchos pacientes con estos ultimos depositos, ya que el torotrasto se utilizo con

  4. Estudio clinico micologico de onimicosis en ancianos Clinico-mycological study of onychomycosis in elderly patients

    Directory of Open Access Journals (Sweden)

    Mayda Elena Rodriguez-Soto

    1993-06-01

    Full Text Available Se realizó examen físico de las uñas a 210 ancianos y a aquellos que presentaron lesiones sugestivas de onicomicosis se les realizó toma de muestra con el objetivo de conocer los principales agentes causales, las características e incidencia de las lesiones. Se confirmó el diagnóstico mediante el aislamiento del agente causal en 74 de los casos procedentes principalmente de las uñas de los pies, para una incidencia de 35,2. La tinea pedis se presentó en el 25,7% de los casos, mientras que la enfermedad asociada más frecuente fue la Diabetes mellitus; entre las características clínicas de las uñas predominaron el engrosamiento, la pérdida del brillo y la aparición de estrías longitudinales. Existió una correspondencia significativa entre el examen microscópico directo y el cultivo. La especie de dermatofito predominate fue Trichophyton rubrum, mientras que Candida parapsilosis fue la más aislada entre las especies de Candida.Physical examination of nails was carried out in 210 elderly patients and nail scrapings were obtained from onychomycosis suggested lesions in order to determine their causative agents, incidence and clinical characteristics. Diagnostic was confirmed by the isolation of the agents from 74 patients, mainly from toe-nails (incidence 35,2. Tinea pedis occurred in 25% of the cases and Diabetes mellitus was the most prevalent associated disease and the most frequent clinical characteristics were the thickening, the opacity and the presence of longitudinal strias in the surface of the nails. It was compared the results obtained by microscopic examination and by culture. Trichophyton ru-brum was the most common dermatophyte isolated; Candida parapsilosis was dominant among Candida species.

  5. Motor neuron diseases in the University Hospital of Fortaleza (Northeastern Brazil: a clinico-demographic analysis of 87 cases Doenças do neurônio motor no Hospital Universitário de Fortaleza (Nordeste do Brasil: análise clínico-demográfica de 87 casos

    Directory of Open Access Journals (Sweden)

    CARLOS M. DE CASTRO-COSTA

    2000-12-01

    Full Text Available In this retrospective (1980-1998 study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil, a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs. Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA, 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP, 2 as progressive muscular atrophy (PMA and 1 as monomelic amyotrophy (MA, and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17, 30 to 39 years (n= 18, 40 to 69 years (n= 39 and 70 to 78 years (n= 4. From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS.Neste estudo retrospectivo (1980-1998, analisamos clínico-demograficamente, a partir dos prontuários do Hospital Universitário de Fortaleza (Brasil, um grupo de 87 pacientes que apresentavam sinais e sintomas de doenças do neurônio motor (DNMs. Eles foram diagnosticados clinicamente, e através de exames complementares. Para o diagnóstico da esclerose lateral amiotrófica (ELA, usamos os critérios da Federação Mundial de Neurologia. A análise clínico-demográfica dos 87 casos de DNMs evidenciou a existência de 4 casos de atrofia muscular espinhal (AME, 5 casos de variantes da ELA: 2 de paralisia bulbar progressiva (PBP, 2 de atrofia muscular progressiva (AMP e 1 de amiotrofia monomélica (AM, e 78 casos de ELA. Esses últimos eram constituídos de 51 homens e 27 mulheres, com

  6. Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus

    Directory of Open Access Journals (Sweden)

    Kyung-Ja Cho

    2017-07-01

    Full Text Available Background Basaloid squamous cell carcinoma (BSCC is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has been suggested to originate from a totipotent primitive cell in the basal cell layer of the surface epithelium or in the proximal duct of secretory glands. Methods Twenty-six cases of head and neck BSCC from Asan Medical Center, Seoul, Korea, reported during a 14-year-period were subclassified into basal, ductal, and mixed subtypes according to the expression of basal (cytokeratin [CK] 5/6, p63 or ductal markers (CK7, CK8/18. The cases were also subject to immunohistochemical study for CK19, p53, cyclin D1, epidermal growth factor receptor (EGFR, and p16 and to in situ hybridization for human papillomavirus (HPV, and the results were clinico-pathologically compared. Results Mixed subtype (12 cases was the most common, and these cases showed hypopharyngeal predilection, older age, and higher expression of CK19, p53, and EGFR than other subtypes. The basal subtype (nine cases showed frequent comedo-necrosis and high expression of cyclin D1. The ductal subtype (five cases showed the lowest expression of p53, cyclin D1, and EGFR. A small number of p16- and/or HPV-positive cases were not restricted to one subtype. BSCC was the cause of death in 19 patients, and the average follow-up period for all patients was 79.5 months. Overall survival among the three subtypes was not significantly different. Conclusions The results of this study suggest a heterogeneous pathogenesis of head and neck BSCC. Each subtype showed variable histology and immunoprofiles, although the clinical implication of heterogeneity was not determined in this study.

  7. Acute subdural hematoma and diffuse axonal injury in fatal road traffic accident victims: a clinico-pathological study of 15 patients Hematoma subdural agudo e lesão axonal difusa em vítimas fatais de acidente de trânsito: estudo clínico-patológico de 15 pacientes

    Directory of Open Access Journals (Sweden)

    Sebastião Nataniel Silva Gusmão

    2003-09-01

    Full Text Available OBJECTIVE: Although acute subdural hematoma (ASDH and diffuse axonal injury (DAI are commonly associated in victims of head injury due to road traffic accidents, there are only two clinico-pathological studies of this association. We report a clinical and pathological study of 15 patients with ASDH associated with DAI. METHOD: The patients were victims of road traffic accidents and were randomly chosen. The state of consciousness on hospital admission was evaluated by the Glasgow coma scale. For the identification of axons the histological sections of the brain were stained with anti-neurofilament proteins. RESULTS: Twelve of the 15 patients were admitted to hospital in a state of coma; in three patients, the level of consciousness was not evaluated, as they died before hospital admission. CONCLUSION: The poorer prognosis in patients with ASDH who lapse into coma immediately after sustaining a head injury, as described by several authors, can be explained by the almost constant association between ASDH and DAI in victims of fatal road traffic accidents.OBJETIVO: Embora o hematoma subdural agudo (HSDA e a lesão axonal difusa (LAD estejam frequentemente associados em vítimas de trauma crânio-encefálico causado por acidentes de trânsito, há somente dois estudos clínico-patológicos sobre esta associação. Relatamos o estudo clínico-patológico de 15 pacientes com HSDA associado com LAD. MÉTODO: Os pacientes, vítimas de acidentes de trânsito, foram selecionados aleatoriamente. O estado de consciência à admissão hospitalar foi avaliado pela escala de coma de Glasgow. Para a identificação dos axônios, os cortes histológicos do cérebro foram corados com antisoro anti-proteínas do neurofilamento. RESULTADOS: Doze dos 15 pacientes foram admitidos no hospital em estado de coma; em três pacientes, o nível de consciência não foi avaliado, pois eles faleceram antes da admissão hospitalar. CONCLUSÃO: O pior prognóstico em pacientes

  8. Sporadic Creutzfeldt-Jakob disease: a clinico-neuropathological analysis of nine definite cases Doença de Creutzfeldt-Jakob do tipo esporádico: análise clínico-neuropatológica de nove casos da forma definida

    Directory of Open Access Journals (Sweden)

    CARLOS M. DE CASTRO COSTA

    1998-09-01

    Full Text Available The authors have analyzed clinico-neuropathologically nine cases of the definite sporadic form of Creutzfeldt-Jakob disease (CJD. All cases were female, with mean age of 62.7 years. Eighty-nine percent of the patients exhibited prodromal and initial psychiatric symptoms; definite signs of dementia, and myoclonus were present in 100% of cases. The EEG was abnormal in all cases and pseudoperiodic paroxysms were present in 56% of the patients. Their evolution time ranged from 3 to 19 months. Neuropathologically, brain and cerebellar atrophy, spongiosis, astrocytosis and neuronal loss were present in 100% of the patients. In 5 (56% of these 9 cases, prion protein (PrP amyloid plaques were detected in the cerebellum, by optical- and electronmicroscopy. There was a positive correlation between the number of plaques and the evolution time. The authors outline the similarities of their cases in the elderly with the new variant of CJD described in young people.Os autores analisaram, do ponto de vista clínico e neuropatológico, nove casos da forma esporádica definida da doença de Creutzfeldt-Jakob (DCJ. Todos eles eram mulheres, com idade média de 62,7 anos. Oitenta e nove por cento dos pacientes exibiram sintomas psiquiátricos prodrômicos e iniciais; sinais típicos de demência e mioclonias estavam presentes em 100% deles. O EEG foi anormal em todos os casos e apresentou paroxismos pseudoperiódicos em 56% dos pacientes. O tempo de evolução da doença variou de 3 a 19 meses. Do ponto de vista neuropatológico, atrofia cerebral e cerebelar, espongiose, astrocitose e perda neuronal estavam presentes em 100% dos pacientes. Em 5 (56% dos 9 casos, foi evidenciada, por microscopia óptica e eletrônica, a presença de placas amilóides de proteína prion (PrP no cerebelo. Havia correlação positiva entre o número de placas e o tempo de evolução da doença. Os autores salientam as semelhanças desses seus casos de pacientes idosos com a nova

  9. Quistes de los maxilares

    Directory of Open Access Journals (Sweden)

    Ivan Alberto Manotas Arevalo

    2013-12-01

    Full Text Available Los Grandes Quistes de los Maxilares han estado vinculados siempre a la humanidad, desde tiempos remotos, pues han sido halladas en restos de especimenes fosiles, han llamado la atencion de los clínicos, en torno a su etiologia, en la que se ha introducido la participacion de la genetica, (demostrada en el desarrollo de los queratoquistes maxilares, la fisiopatologia, caracteristicas histologicas (inmunohistoquimica, posibilidades diagnosticas por la imagen, (como la tomografia computarizada y la resonancia nuclear magnetica y otras pruebas. Además llaman la atención al estudio, por sus alternativas de manejo especialmente las formas radicales, y el analisis de asociaciones a otras patolo-gias benignas y malignas, y de la recurrencia muy alto de algunas de estas lesiones. Mucho se ha desarrollado para elucidar su naturaleza real, estadificar adecuadamente la lesion descartando asocia-ciones patologicas sindromicas, indicar un tratamiento apropiado, y realizar seguimientos a largo plazo. Este articulo pretende recaudar una information general que de parametros para abordar el estudio de los quistes maxilares a partir de la presentacion de un caso clinico.

  10. Neurosyphilis: A Clinico- Radiological Study | Patel | African Journal ...

    African Journals Online (AJOL)

    Imaging changes included normal findings, infarcts, meningeal based mass lesions, spinal intra-medullary hyper-intensities, cranial nerve enhancement and intra-medullary enhancing mass lesions. There was no difference in CSF cellular or chemistry findings between those with neurosyphilis who were HIV positive and ...

  11. Clinico-hysteroscopic analysis of severe intrauterine adhesions ...

    African Journals Online (AJOL)

    Secondary dysmenorrhea and cyclical abdominal pain were found in 10.8% and 31.6% of the women respectively. The main aetiological events were complicated caesarean section (42.1%) and abdominal myomectomy (26.3%). The adhesions were mainly dense (52.6%) and multiple (94.7%) with complete involvement of ...

  12. CLINICO PATHOLOGICAL STUDY OF NEPHROTIC SYNDROME IN ADULTS

    Directory of Open Access Journals (Sweden)

    Deepa

    2015-11-01

    Full Text Available CONTEXT: Etiology of nephrotic syndrome (NS in adults varies depending on the geographical location and is poorly studied in the Indian subcontinent. AIMS: To study the clinical features, biochemical profile and histopathological pattern of various types of glomerulonephritis in adult patients with nephrotic syndrome. METHODS AND MATERIAL: Patients (≥15 years old with nephrotic syndrome presenting to our center and undergoing a kidney biopsy from May 2009 to August 2011 were included for this study. All biopsies were subjected to light microscopy.The histopathological spectrum was analyzed according to the various clinical parameters. STATISTICAL ANALYSIS USED: Analysis was performed using SPSS software version 19.Measures obtained included percentages,medians,correlation coefficients and chi square tests. RESULTS: A total of 50 kidney biopsies were included in analysis. Twenty six(52% patients were male and twenty four(48% patients were female. The average age at presentation was 15-24 years. Among the patients, 22(44% were diagnosed with primary glomerular diseases (PGD and 4(8% with secondary glomerular diseases (SGD. The most common histological lesions was membranous nephropathy(24.4% followed by minimal change disease (MCD (17% and membranous nephropathy (MN (17%. The most common form of SGD was lupus nephritis (LN (10%. Membranous nephropathy and focal segmental glomerulosclerosis were the commonest lesions in males.Among females,membranous nephropathy was the commonest. 31(62% patients were in the age group of 15-34 yrs, 17(34% were in the age group 34- 54yrs and only 2(4% were aged above 55yrs. Among the patients, 6(12% had serum creatinine ≥1.5 mg/dL and 12(24% had either macroscopic or microscopic hematuria. CONCLUSIONS: Membranous nephropathy is still the commonest type of nephrotic syndrome in adults followed closely by focal segmental glomerulosclerosis and minimal change disease as per this study.

  13. Clinico-epidemiologic characteristics of spinal muscular atrophy ...

    African Journals Online (AJOL)

    Type I was the commonest type (60.6%), followed by type II (26.79%), and type III (8.8%). Consanguinity was reported in 45.5 and family history in 47.8% of patients. Molecular study was done and 54.5% of patients (types I and II) have homozygous deletion of exon 7, 36.3% of whom had also homozygous deletion of exon 8 ...

  14. Clinico-epidemiologic characteristics of spinal muscular atrophy ...

    African Journals Online (AJOL)

    Rabah M. Shawky

    Deletion;. Chromosome 5;. Mutations. Abstract Spinal muscular atrophy (SMA) is characterized by progressive hypotonia and muscular weakness because of progressive degeneration of alpha motor neuron from anterior horn cells in the spinal cord. It is inherited by an autosomal recessive pattern. The precise frequency of ...

  15. Oral submucous fibrosis: A clinico-histopathological study in Chennai

    Directory of Open Access Journals (Sweden)

    Kiran Kumar K

    2007-01-01

    Full Text Available Background: Oral submucous fibrosis (OSF is a precancerous condition associated with the use of areca nut in various forms. There are very few reports to correlate the clinical stage to histopathological grading in OSF. Materials and Methods: A hospital-based study was conducted on 75 OSF cases who visited our hospital in Chennai from 2000-2003. A detailed history of each patient was recorded along with a clinical examination. Biopsy was performed for histopathological correlation. Clinical stage of the disease in terms of the ability to open one′s mouth was correlated with histopathological grading. Results: The male to female ratio of OSF cases was 6:1. All forms of areca nut products were associated with OSF. Chewing of paanmasala was associated with early presentation of OSF as compared to chewing of the betel nut. Out of 57 cases, which were in clinical stage II, 91.2% had histological grading of I and II in equal proportions and 8.8% had histological grade III. Out of 13 cases that showed a clinical stage of III, 52% showed a histological grade of II, 40% grade III and 8% grade I. Conclusion: In the present study, there was no direct correlation between clinical stages and histopathological grading. The possibility of difference in the severity and extent of fibrosis in different regions of the oral mucosa and involved muscles were considered as contributory factors for this variation.

  16. Clinico-morphological characteristics of reparation of acute radiation ulcer

    International Nuclear Information System (INIS)

    Petrik, V.D.; Yakovleva, N.D.; Bardychev, M.S.

    1979-01-01

    The mechanism of reparative processes under the effect of various drugs was studied in experimental acute radiation ulcer of rats. It was established that at the stage of marked exudative-necrotic processes the use of antiinflammatory and antiexudative substances (bariz, dimethylsulfoxyde) led to normalization of the microcirculation that reduced the time of radiation ulcer healing. The use of anabolic steroids (retabolil) intensified metabolism that also produced a favourable effect on the reparative processes

  17. AIDS-related malignancies: clinico-radiological correlation

    International Nuclear Information System (INIS)

    Ferrozzi, F.; Bova, D.; Campodonico, F.; DeChiara, F.; Marini, M.; Bassi, P.

    1995-01-01

    Our goal is to report the imaging findings of the most frequent HIV-related malignant neoplasms and outline them in relation to their atypical biological and structural behaviour. It is our opinion that a careful evaluation of clinical history and status is mandatory for the proper diagnosis and staging in such pathologies. We also review the current etiopathogenetic theories that attempt to link these two deadly pathologies. (orig./MG)

  18. CLINICO-PATHOLOGICAL STUDY OF CARCINOMA GALL BLADDER

    Directory of Open Access Journals (Sweden)

    Ravindra

    2015-12-01

    Full Text Available INTRODUCTION Gall bladder cancer is 5th most common cancer of GIT. It is associated with cholelithiasis in significant number of patients. Cholelithiasis is cause or effect of gall bladder cancer is still uncertain. There are many risk factors which are common to both gall stones and cancer. Preoperative diagnosis of gall bladder cancer is increased with better and new investigation facilities. AIM The study was aimed to assess clinicopathological behaviour, sociodemography, diagnostic modalities and treatment of cancer gall bladder. MATERIAL AND METHODS It was a type of prospective study which included 75 patients with clinical features suggestive of biliary disease. Various diagnostic modalities and treatment options were assessed along with sociodemography and clinical picture. RESULT Common clinical features were pain abdomen, obstructive jaundice and lump. Nearly one third of the patients were having anaemia and abnormal liver function tests. Majority had gall bladder fossa mass with liver extension and gall stones. The most common histopathological variety of carcinoma Gallbladder was Adenocarcinoma. CONCLUSION Carcinoma Gallbladder was found to affect predominantly the older female patients after the age of 40 years. Cholelithiasis was found in 69.3% patients of carcinoma Gallbladder. The most common clinical presentation was pain abdomen (90.7%. The most common histopathological variety of carcinoma Gallbladder was Adenocarcinoma. Majority of patients were treated with palliative measures.

  19. A prospective study on the clinico-pathological presentation and ...

    African Journals Online (AJOL)

    Postoperative complications included disfigurement in cases with big tumours, recurrence, loss of masticatory function and difficulties with speech in cases of maxillary OM. Conclusion: Aggressive local resections in both the maxilla and the mandible result in low rates of recurrence. Early suspicion of the possibility of ...

  20. Effect of xylazine sedation on some clinico-physiological and ...

    African Journals Online (AJOL)

    Xylazine is classified pharmacologically as an effective sedative, analgesic, muscle relaxant, immobilizing and hypnotic agent in domestic animals (Torre and Erausquine, 1988; Ewing, 1990; Adams, 2001). Xylazine is also known to significantly ameliorate the effects induced by stress stimuli (Ali et al., 2006). It does not ...

  1. CLINICO-AETIOLOGICAL STUDY OF LOWER MOTOR NEURON FACIAL PALSY

    Directory of Open Access Journals (Sweden)

    Souvagini Acharya

    2017-05-01

    Full Text Available BACKGROUND The facial nerve paralysis is a broad term having so many differential diagnoses starting from congenital causes to malignant tumour. Accurate diagnosis with localisation of the site of injury or compression and timely intervention has become a challenge to an otorhinolaryngologist. Objective- To outline the incidence of the different aetiologies and the profile of peripheral facial nerve paralysis patients in the Otolaryngology Dept. of ENT in VIMSAR, Burla. MATERIALS AND METHODS The records of 53 patients with facial nerve paralysis seen during the years of 2016 & 2017 were analysed. RESULTS From the 53 patients analysed, 60.4% were male, maximum cases 35.85% were in 3 rd decade of age and had the right side of the face involved in 62.26%. Bell´s palsy was the most frequent aetiology (66.04%, others are traumatic (11.32%, Ramsay Hunt syndrome (1.89%, CSOM (16.98%, malignant otitis externa (1.89%. One case of Bell´s palsy during pregnancy was also seen in this series. CONCLUSION The data found are similar to the most of the literature showing that Bell´s palsy is still the most frequent. Males are more commonly affected with a preponderance to involve right side of face.

  2. Neonatal necrotizing entero-colitis: A clinico-surgical study

    Directory of Open Access Journals (Sweden)

    A.I. Eid*

    2013-12-01

    Conclusion: Early diagnosis and intensive medical and surgical treatment were mandatory to minimize both morbidity and mortality from NEC. Surgical management should be determined according to the special circumstances of each case. However, the optimum choice between peritoneal drainage and laparotomy remains controversial. Gestational age, birth weight, age at admission, and treatment modality are definite prognostic factors as regard morbidity and mortality of patients with NEC.

  3. [Clinico-endoscopic characteristics of gastroduodenal Campylobacter infection in children].

    Science.gov (United States)

    Korovina, N A; Levitskaia, S V; Bokser, G V; Spirina, T S; Girshovich, E S

    1989-01-01

    During diagnostic esophagogastroduodenoscopy, 104 children aged 6 months to 14 years were subjected to spot biopsy of the mucous membrane of the antral part of the stomach and duodenal bulb with a purpose of subsequent studies for Campylobacter pyloris (C. P.) including primary microscopy, the screening-urease test and culture isolation followed by its identification according to all the necessary biochemical tests. C. P. were detected in 50% of the children examined including 9 out of 12 patients suffering from ulcer disease of the duodenum. It was shown that the C. P. incidence noticeably rose with an increase of the period of the gastroenterologic anamnesis. The characteristic clinical and endoscopic signs of the illness were defined, associated with most or less probable C. P. isolation. It has been established that the findings of the screening-urease test cannot form the basis for the final diagnosis of pyloric campylobacteriosis in children.

  4. Clinico-haematological and serum biochemical alterations in ...

    African Journals Online (AJOL)

    An increase in serum CRE and BUN values were recorded in all cases of pyometra which reduced to lower levels during both treatments in follow-ups. All the haemato-biochemical parameters were comparable to their respective reference values after either medicinal treatment or ovariohysterectomy of dogs. Thus the dogs ...

  5. A Clinico-epidemilogical Study of Gental Warts

    Directory of Open Access Journals (Sweden)

    D D Ganguli

    1983-01-01

    Full Text Available The epidemiological and clinical, characteristics of 109 patients (94 then and 15 women with gental warts were studied at the STD Training and Denimonstration Centre, Safdarjang Hospital, New Delhi. Genital warts is a disease of young adults and correlates with sexual maturity. The majority of patients were poor socio-economically, non-promiscuous and not addicted to alcohool. Most of the with the disease, were single and the women . married, reflecting the differing sources of acquisition of the disease. Homosexuality played a significant role in the acquisition of perianal warts in males. The mean incubation period. Warts were more numerous in women.. Long foreskins, by presenting a more moist environment probably preispose to the acquisition and propagation of warts. Personal hygiene soon after coitus did not seem significant, in the prevention of warts Cutaneous warts were associated in 8% of the cases. Concomitant sexually transmitted infections were present in 38.5% of the patients. Genital warts showed a preferential distribution at sites frequently subjected to the trauma of coitus.

  6. Clinico-chemical studies on subacute cadmium poisoning in rabbits

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikawa, H; Ohsawa, M; Kaneta, M

    1974-01-01

    GOT, GPT, LDH, total Ac-P, prostatic Ac-P, cholesterol, free fatty acid, Ca, and P in plasma were measured once a week on rabbits injected subcutaneously with 0.5 and 1.0 mg Cd/kg daily for 11 weeks respectively, and Cd, Cu, Mn, and Zn contents in organs were determined at the termination of the experiment. Prostatic Ac-P activity, cholesterol, and free fatty acid levels in plasma rose in the early stage of administration, and GOT, GPT, LDH, and Al-P activities rose in the latter stage of administration. Ca and P levels in plasma did not change in any periods of the experiment. From these results, it could be concluded that a measurement of prostatic Ac-P, cholesterol, and free fatty acid is adequate to evaluate excess intake of Cd. Cd contents in heart, lungs, spleen, and testes of rabbits injected with 1.0 mg Cd/kg increased significantly compared with those with 0.5 mg Cd/kg, but a difference between the two groups in Cd contents in liver, kidneys and submandibular glands which contained high concentration of Cd was not recognized. Zn contents in organs of rabbits injected with Cd increased remarkably, while Cu contents decreased generally. This phenomenon was especially remarkable in liver and kidneys. 31 references, 7 figures, 2 tables.

  7. [Cerebral gliosarcoma: clinico-pathologic study of 8 cases].

    Science.gov (United States)

    Ayadi, Lobna; Charfi, Slim; Khabir, Abdemajid; Kalle, Rim; Sellami, Ahmed; Makni, Saloua; Boudawara, Zaher; Sellami-Boudawara, Tahya

    2010-03-01

    Gliosarcomas are biphasic neoplasms composed of a glioblastoma admixed to a sarcomatous component with different lines of differentiation. Histogenesis of these tumors is still discussed. Our objective is to specify clinical and pathological characteristics of this rare neoplasm and to discuss its histogenesis. Retrospective study of eight cases of gliosarcomas diagnosed between January 1998 and December 2004. Clinical, radiological, therapeutic and follow-up data were reviewed. Histological features and immunohistochemical results were also included in this review. Five patients were male, three women with a median age of 50.7 (range 31-74 years). Symptoms were dominated by intracranial hypertension and paralysis. The most common location was parietal or temporo-parietal (5 cases: 62.5%). Pathological exam including histochemical and immunohistochemical study confirmed the diagnosis of gliosarcoma in all cases. Sarcomatous component had features of fibrosarcoma in 5 cases, osteosarcoma in 2 cases and malignant fibrous histiocytoma in 1 case. All patients were treated by surgical excision (complete in five cases and partial in three cases). Adjuvant radiotherapy was received in three cases. One patient was lost on follow-up. Two patients died from postoperative. complications and the five remaining patients died with a medium follow up of 9 months (extremes: 2-24 months). Clinical, radiological and follow-up features of gliosarcomas share great similarities with glioblastomas. Histopathological, histochemical and immunohistochemical studies are helpful in accuracy diagnosis. Recent cytogenetic and molecular data support a monoclonal origin for these tumors.

  8. Angina monocitica con sovrainfezione da Prevotella denticola: caso clinico

    Directory of Open Access Journals (Sweden)

    Maria Teresa Allù

    2005-06-01

    Full Text Available Monocytic angina with superinfection of Prevotella denticola: clinical case Monocytic angina is a clinical sindrome caused by Epstein-Barr virus characterized by fever, pharyngitis, exudative tonsillitis, swollen lymphoglands, splenomegaly and hepatomegaly.The inflamed pharynx and necrotic tonsils of infectious mononucleosis are subject to bacterial superinfection initially or during the course of the illness; the reduced PO2 tension and low oxidation-reduction potential that prevail in a vascular and necrotic tissues favour the growth of anaerobes. In this article we reported the clinical case of a ten years old children, who presented fever and tonsillopharyngitis; he was treated with cefotaxime and piperacillin, he did not improve in health. He was admitted to hospital (Department of Otorhinolaryngology. The patient was treated with aminoglycoside (tobramycin, piperacillin and cortisone; the clinical situation deteriorated. Pus sample was collected from the tonsils and cultured. Isolated strain from culture anaerobic was identified biochemically (Rapid-ID32ANA.The microorganism isolated was: Prevotella denticola (oral anaerobic gram-negative rods; β-lactamase production was tested by using the chromogenic cephalosporin disk test.The susceptibility to antibiotics was performed according to NCCLS recommendations. Prevotella denticola (β-lactamase production was resistant to penicillin, cefoxitin, cefotetan, piperacillin, clindamycin and metronidazole it was susceptible to piperacillin-tazobactam, amoxicillin-clavulanate, ticarcillin-clavulanate, imipenem and chloramphenicol. Children was treated with piperacillin-tazobactam, with rapid symptomatic relief.

  9. Clinico-roentgenological semiotics of malignant contact bone tumors

    International Nuclear Information System (INIS)

    Akperbekov, A.A.; Polatkhanova, K.B.; Murtuzaeva, Z.D.

    1986-01-01

    Bone changes were analyzed in 42 patients (aged 18 to 65) with malignant contact bone tumors. Probable causes of their origin were discussed. Of 42 patients corticopleural cancer (Pancoast's tumor) was noted in 24, skin cancer developing against a background of a chronic inflammatory process or trauma, was noted in 13, sarcomatous soft tissue tumors in 5. A method of roentgenography using routine and spot radiographs was used for X-ray examination of the patients. In some cases the examination was supplemented with hard and soft X-ray films, tomography and electroroentgenography

  10. Ipertensione arteriosa, continuum cardiovascolare e ruolo clinico dei sartanii

    Directory of Open Access Journals (Sweden)

    Maurizio Destro

    2011-03-01

    Full Text Available The cardiovascular and cardiorenal continuum comprises the transition from cardiovascular risk factors to endothelial dysfunction and atherosclerosis, to chronic congestive heart failure, and-stage renal disease or premature death. RAAS (renin-angiotensin-aldosterone system is involved in all steps along this pathway. Data from clinical studies involving valsartan and other ARBs provide evidence of the reduction of risk of cardiovascular events, and end-organ damage in the heart, kidneys and brain. This paper summarizes the status on research of ARBs based on clinical trials and regulatory approval.

  11. A clinico-pathological study of 70 cases of pemphigus

    Directory of Open Access Journals (Sweden)

    Arya S

    1999-01-01

    Full Text Available A clinicopalhological study of 70 cases of pemphigus observed over a span of four and a half years from January 1992 to June 1996 at the Sir J.J. Group of Hospitals and Grant Medical College, Mumbai is reported. Pemphigus vulgaris constituted the single largest group of 43 cases, followed by pemphigus foliaceus (25 cases and pemphigus vegetans (2 cases. Majority of the cases were seen in the age group of 21-60 years, with a slight male predominance. The youngest patient was 14 years while the eldest was aged 75 years. Mucosal involvement was seen in 31 cases of pemphigus vulgaris, as opposed to only 5 cases of pemphigus foliaceus. Flaccid bullae were present in 100% cases. Pruritus was complained of in 14 cases, though it was more common in pemphigus vegetans and vulgaris. Salient histopathological features of pemphigus vulgaris observed were (I intraepidermal suprabasal blisters (35 cases, (2 presence of acantholytic cells (40 cases, (3 "Row of tombstone appearance" (I8 cases and (4 acantholysis involving follicular sheath (20 cases. Main histopathological features of pemphigus foliaceus were (1 subcorneal blister (15 case, (2 acantholysis (24 cases and (3 bulla cavity containing inflammatory infiltrate (12 cases. Both cases of pemphigus vegetans showed hyperkeratosis, papillomatosis and irregular acanthosis with intra-epidermal eosinophilic abscesses besides suprabasal lacunae.

  12. Clinico-roentgenological characteristic of early stomach neoplasm

    International Nuclear Information System (INIS)

    Golub, G.D.

    1988-01-01

    Peculiarities of clinic and roentgenosemiotics of early stomach neoplasms in patients were analyzed. Roentgenological picture of early stomach neoplasms depends on anatomic growth shape and size of neoplasms, its localization and on manifestation of inflammatory and functional chages accompanying the neoplasm. Application of complex of gastrological examination including roentgenological diagnostic method, gastrofibroscopy and morphological examination of the tissue permits to diagnose early stomach neoplasm in 95,4 % of patients. 8 refs

  13. Case Presentation at a Clinico-Pathological Conference*

    African Journals Online (AJOL)

    of low-strength mannitoi to reduce possible cerebral oede- ma. His convulsions were ..... No vascular lesions were noted but a few degenerate muscle fibres were ... The liver necrosis appears to have been a terminal event. Cases of fibrosing ...

  14. Viral Warts-A Clinico-Epidemiological Study

    Directory of Open Access Journals (Sweden)

    Laxmisha Chandrashekar

    2003-01-01

    Full Text Available Although clinical criteria, laboratory diagnosis and treatment are well established, scanty attention has been paid to prevalence and pattern of viral warts in India. HIV is widely prevalent and its influence on the number and morphology of viral warts has not yet been studied in our setup. Hence, this study was undertaken. One hindered and forty four cases of viral warts were studied between September 2000 and June 2002 at the department of Dermatology and STD, JIPMER, Pondicherry. These included 81childeren and 63 adults. In Children, viral warts were most commonly seen in the age group of 10to14 years (41.9%, whereas in adults, the most commonly seen in the age 14to20 years (46.03%. The average age at presentation was 11.5 years. The male to female ratio was 2.2 to 1 in children and 1.8 to 1 in adults. Family history of warts was observed in 27.7% of the cases. In children, multiple site involvement (62.9% was more common than single site involvement. The most commonly involved site was hand in children as also in adults. In adults, single site involvement (66.6%was more common than multiple site involvement. The most common type of wart seen in both children and adults was the common wart. Twenty percent of the cases showed koebnerization. Four cases were found to be seropositive for HIV infection, who were adult with genital warts, but florid manifestations were not seen.

  15. Hemangiopericytome Meninge: Rapport clinico-pathologique d\\'un cas

    African Journals Online (AJOL)

    Nous rapportons l\\'observation d\\'un hémangiopéricytome de localisation méningée (HPCM) chez une femme de 42 ans reçue à l\\'Hôpital Général de Yaoundé, Cameroun. Cette tumeur est rare chez nous, et la localisation méningée exceptionnelle. Le diagnostic histologique est difficile, la tumeur étant souvent confondue ...

  16. PICTORIAL ESSAY Traumatic Brown-Sequard syndrome– clinico ...

    African Journals Online (AJOL)

    A 34-year-old man presented with a history of a stab wound to the left side of the neck. Physical examination revealed an ipsilateral left-sided hemiplegia and contralateral loss of sensation. A clinical diagnosis of. Brown-Sequard syndrome was made. Magnetic resonance imaging. (MRI) findings demonstrated ...

  17. Clinico-etiologic correlates of onychomycosis in Sikkim

    Directory of Open Access Journals (Sweden)

    Adhikari Luna

    2009-04-01

    Full Text Available Aims and objectives: The etiological spectrum of any superficial mycosis is largely dependent on the flora in the immediate environment of the individual. It is influenced by the geographic, climatic and occupational factors. The study is basically to formulate baseline data for the species prevalence of various dermatophytes in patients with onychomycosis attending the Central Referral Hospital, Gangtok, Sikkim. Materials and Methods: Thirty-four clinically suspected cases of onychomycosis were subjected to mycological studies. Results: Thirty-two (94.12% cases were positive for fungal elements by direct microscopy and 28 (82.35% by culture. Young adults in the age group of 21-30 years were mainly affected. The male:female ratio was 1.125:1. Dermatophytes were isolated in 18 cases (64.29%. Trichophyton tonsurans (44.44% was the most common isolate followed by T. mentagrophytes (22.22%, T. rubrum (11.11%, T. verrucosum (11.11% and Microsporum audouinii (11.11%. Apart from dermatophytes, Aspergillus niger (21.43% and Penicillium marneffei (14.28% were also isolated. Conclusion: Dermatophytes, mainly T. tonsurans, as well as moulds other than dermatophytes were isolated from onychomycosis patients in Gangtok, Sikkim.

  18. Clinico-etiologic correlates of onychomycosis in Sikkim

    OpenAIRE

    Adhikari Luna; Gupta Atrayee; Pal Ranabir; Singh T.S.K

    2009-01-01

    Aims and objectives: The etiological spectrum of any superficial mycosis is largely dependent on the flora in the immediate environment of the individual. It is influenced by the geographic, climatic and occupational factors. The study is basically to formulate baseline data for the species prevalence of various dermatophytes in patients with onychomycosis attending the Central Referral Hospital, Gangtok, Sikkim. Materials and Methods: Thirty-four clinically suspected cases of onychomycosi...

  19. [Pyramidal syndrome in lateral amyotrophic sclerosis: clinico-morphological analysis].

    Science.gov (United States)

    Musaeva, L S; Zavalishin, I A; Gulevskaia, T S

    2003-01-01

    Retrospective clinical analysis with a special focus on pyramidal syndrome expression in the disease course as well as morphological study of brain and spinal structures in all levels of cortical-spinal projection (from brain motor cortex to spinal lumbar segments) have been conducted for 11 section cases of lateral amyotrophic sclerosis (LAS), sporadic type. Two groups of patients were studied: with pronounced pyramidal syndrome (spasticity, hyperreflexia, etc)--7 cases and with some signs of pyramidal deficiency (anisoreflexia, stability of peritoneal reflexes)--4 cases. Pyramidal syndrome in LAS is considered as an emergence of current neurodegenerative process, embracing a significant part of upper motor neurons of both precentral convolution and its axons along the whole length of cerebrospinal axis in the form of cytoplasmic inclusions and axonal spheroids. A presence of pathomorphological changes in other upper segmental structures of motor control reveals their role in pyramidal deficiency. Comparative analysis showed that expression of pyramidal syndrome signs and its correlation to atrophic paresis appearances is specifically determined by the severity of upper and lower motor neurons lesions. With regard to morphological changes in CNS structures, the peculiarities of some pyramidal syndrome appearances in LAS are analyzed.

  20. A clinico-pathological study of hypopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Ahmed, M.; Khan, N.U.

    2002-01-01

    Objective: To evaluate the risk factors involved, mode of presentation and the pattern of malignancies in hypopharynx. Design: It was a prospective study. Place and Duration of Study: The study was conducted at the Departments of Otolaryngology and pathology, Combined Military Hospital Kharian, over a period of two years (may 1998 to April 2000). Subject and Methods: Thirty patients with malignant tumors of the hypopharynx were studied. Evaluation was done by detailed history for presenting symptoms and possible risk factors, endoscopy and histological examination of the specimen. Results: out of 30 patients, 24 were males and 6 females with a male to female ratio of 4:1. A majority of them was in the 7th decade. History of tobacco intake in the form to smoking or chewing was present in 87%. Presenting symptoms were dysphagia, pain in the throat and neck mass. Most common site of origin was pyriform fossa (53%). All the malignant tumors were squamous cell carcinomas. Well-differentiated category was the most common (60%), followed by moderately-differentiated (26.5%) and poorly-differentiated (13.5%) varieties. Conclusion: Our findings are consistent with contemporary literature. There are close similarities with regard to sex tobacco use, presentation and type of malignancy. In our study, well-differentiated category was more common than the poorly differentiated one. (author)

  1. Clinico-pathological Correlation of Digital Rectal Examination ...

    African Journals Online (AJOL)

    Aims and Objective: This study aims at correlating different digital rectal examination (DRE) abnormalities with histopathological results in patients with prostatic diseases. Materials and Methods: A prospective study of 236 patients who underwent prostate needle biopsy (PNB). Inclusion criteria were presence of abnormal ...

  2. POLYPOIDAL MASSES IN NOSE: A CLINICO - PATHOLOGICAL CORRELATION STUDY

    Directory of Open Access Journals (Sweden)

    Vijay Peruvaje

    2015-01-01

    Full Text Available INTRODUCTION : A polypoidal mass in the nasal cavity is a condition commonly encountered by the Otorhinolaryngologist. A diverse group of lesions may present themselves as polypoidal masses. A number of benign looking polyps often turn out to be malignant lesions or vice versa. OBJE CTIVES : This study is intended to clinically differentiate the various conditions presenting as nasal polypoidal lesions , to understand their exact nature by histopathological examination and thereby learn the relative incidence of individual conditions en countered. METHODOLOGY : D etailed history , clinical examination and histopathological examination of nasal polypoid masses were done in 73 patients. Incidence , clinical features and histopathological correlation of all the polypoidal masses were ascertained. RESULTS : O f the 73 cases , 53 (72.6% cases were non - neoplastic and 20 (27.4% were neoplastic lesions. The non - neoplastic lesions included nasal polyps , rhinosporidiosis , pyogenic granuloma and mucocoele. Benign neoplasms included inverted papilloma , haemangioma , angiofibroma , neurilemmoma and pleomorphic adenoma. Malignant neoplasms included squamous cell carcinoma , adenoid cystic carcinoma and olfactory neuroblastoma. CONCLUSION : P olypoidal masses in the nose may range from non - n eoplastic lesions to benign and malignant neoplasms with various histopathologic findings. It is impossible to distinguish between such lesions clinically. Hence , it is essential that all polypoidal masses removed should be evaluated histopathologically , t o make a correct diagnosis.

  3. A Clinico-Pathological Study on Benign Breast Diseases

    Science.gov (United States)

    Sangma, Mima B. Maychet; Panda, Kishori; Dasiah, Simon

    2013-01-01

    Background: To study the patterns of clinically benign breast disease in females and to co-relate them with the pathological findings. Methods: One hundred females who attended the Surgery Outpatients Department in Indira Gandhi Medical College and Research Institute, Pondicherry, with various forms of benign breast diseases during the period from October 2011 to September 2012, were studied. Early diagnoses by doing a triple assessment like a clinical examination, FNAC or a core needle biopsy and imaging methods like ultrasonography or mammography, were made within 72 hrs from the first consultation. The clinical diagnoses were compared with the cytological or histological findings wherever possible and their accuracies were evaluated. Results: Out of the 100 female patients who were studied, 87 patients who presented with breast lumps and fibroadenoma, accounted for 48% of the cases, which was the highest number of patients. Fibrocystic changes and breast abscesses came next with 18% and 12% cases respectively. We detected 3 cases of proliferative disease with atypia and one case with florid hyperplasia, which had high and low risk factors respectively, for developing invasive carcinoma. The oldest lady of the group who was clinically diagnosed to have benign disease, was detected to have invasive ductal carcinoma. They were treated in our hospital and were advised follow up. Conclusion: Benign breast diseases are common in female patients and fibroadenoma is the commonest of them all. Triple assessment provided a quick diagnosis and it alleviated unnecessary anxiety from the patients about breast cancer. The clinical diagnosis of a breast lump, as confirmed by cytology and histology, was accurate in 91.95 % of the cases. PMID:23634406

  4. Clinico-pathological analysis of malignant salivary gland tumours in ...

    African Journals Online (AJOL)

    They were made into slides and stained with hematoxylin and eosin (H and E) and periodic acid Schiff (PAS) stains. The slides were reported independently by four pathologists. Diagnosis was made according to the world health organisation (WHO) classification of salivary gland tumours. Case files of these patients were ...

  5. A Clinico- Epidemiological Study Of Filarial Related Orthopaedic Manifestations

    Directory of Open Access Journals (Sweden)

    Patond K.R

    1992-01-01

    Full Text Available An epidemiological study was undertaken to study the incidence and distribution of orthopaedic manifestations of filariasis in an endemic area. A total of 207 cases were clinically examined and investigated. Patients were divided into three groups , viz., Group A: Orthopaedic manifestations with no history of filariasis . Group B: Orthopaedic manifestations with history of filariasis such as microfilaraemia or filarial fevers etc., Group C: Orthopaedic manifestations with chronic manifestations such as elephantiasis, hydrocele etc. To confirm filarial etiology, all the cases were examined for the presence of filarial antibody by indirect ELISA using wuchereda bancrofti microfilarial excretory- secretary antigen (wd Mf ESAg . A total of 61 of 102 patients of Group A, 14 of 21 patients of group B, and 73 of 84 patients of Group C were positive for filarial antibody. This study showed the prevalence of filarial antibody in about 71.4% of various orthopaedic manifestations.

  6. Clinico-roentgenological atlas of congenital malformations in human limbs

    International Nuclear Information System (INIS)

    Luzina, E.V.; Shakirov, Eh.A.

    1990-01-01

    The objective of the present atlas is to familiarize a wide range of physicians with localizations of congenital malformations in human limbs which are little studied clinically and roentgenologically. The atlas illustrates different variants of malformations of upper and lower limbs systematized by nosological principle; multiple and some, rarely occuring system deformations of the skeleton. Malformation features are described and their names are presented in compliance with the international classification taking into account the vocabulary of medical terms. 102 refs.; 121 figs

  7. Case Presentation at a Clinico-Pathological Conference*

    African Journals Online (AJOL)

    globin 15 g/lOO ml, and his white blood cell count 22000/ mm', with 80% neutrophil .... respiration commenced. ... exception a cardiac granuloma may occur with minimal or no joint .... thickened because of oedema and a limited cellular infiltra-.

  8. A clinico-radiological reappraisal of intestinal tuberculosis

    International Nuclear Information System (INIS)

    Tandon, R.K.; Sarin, S.K.; Bose, S.L.; Berry, M.; Tandon, B.N.

    1986-01-01

    Intestinal tuberculosis is still common in developing countries. In 186 patients with intestinal tuberculosis, clinical features, radiological findings and complications were carefully recorded and compared with those from earlier studies with a view to study any possible changes after the liberal use of antitubercular drugs. Sixty two percent of the patients in the present series had had prior exposure to antitubercular drugs. The incidence of systemic symptoms like fever and anorexia, alternating diarrhoea and constipation, peritoneal and lymph node involvements and associated pulmonary lesions were less frequently observed. On the other hand, an indolent and complicated course with intestinal obstruction (47 %) and lower gastrointestinal bleeding (5.5 %) and frequent colonic involvement (19 %) often necessitating surgical intervention appeared to have become more frequent than reported in earlier series. Awareness of these changes in the clinical profile of intestinal tuberculosis should be helpful in the diagnosis and management of the condition. (author)

  9. Miopatia miotubular: estudo clinico, eletrofisiologico e histologico de um caso

    Directory of Open Access Journals (Sweden)

    José L. Alonso

    1981-12-01

    Full Text Available São apresentados os resultados dos exames clínicos, eletrofisiológicos e do estudo do ponto motor, da imunofluorescência, da histoquímica e da ultrami-croscopia da biópsia muscular de um caso de miopatia miotubular. São discutidos estes resultados em relação aos achados de 56 casos desta moléstia consignados na literatura até 1978, sendo dada enfase à etiopatogenia.

  10. Fibrolamellar carcinoma: an unusual clinico-radiological presentation

    International Nuclear Information System (INIS)

    Gupta, Preeti; Dhar, Sunanda; Strickland, Nicola H.

    1999-01-01

    We report a case of fibrolamellar carcinoma presenting in a 26-year old female. The patient had gross ascites at presentation. Imaging studies (ultrasonography and computed tomography) strongly suggested extensive intraperitoneal drop metastases

  11. A Clinico-pathological Study Of Cervical Carcinoma In South ...

    African Journals Online (AJOL)

    (51.2%), vaginal discharge (32.6%), postcoital bleeding (9.3%) and irregular vaginal bleeding (7%). Nearly 80% presented with the advanced form of the disease with 20 (46.5%) and 14 (32.6%) presenting in stage III and IV respectively. 27( 62.8% ) were lost to follow up at various stages of management. Conclusion : The ...

  12. Mogadon endovenoso em pacientes epilepticos: estudo clinico-eletrencefalografico

    Directory of Open Access Journals (Sweden)

    Roberto Sergio Pires de Oliveira

    1979-03-01

    Full Text Available Foi utilizado o Mogadon injetável para o tratamento de 15 casos de "status epilépticus", 10 casos de crises intermitentes de mal epiléptico, 14 casos de síndrome de Lennox, 5 casos de crises mioclônicas e 6 casos de ausências simples. As doses utilizadas variaram entre 3,3 mg e 10 mg. Nos casos de "status epilépticus" e crises intermitentes de mal epiléptico o medicamento fez desaparecer as crises e as alterações irritativas do EEG. Houve remissão em 10 casos e melhora de outros 4 com síndrome de Lennox. A medicação produziu a abolição da sintomatologia em alguns casos de ausências puras; a melhora foi evidente, embora de duração mais curta do que a melhora nas mioclônicas. O único efeito secundário foi a sonolência, observada em alguns casos.

  13. Distrofia muscular congênita estudo clinico de 17 pacientes

    Directory of Open Access Journals (Sweden)

    A. S. B. Oliveira

    1991-09-01

    Full Text Available Descrevemos 17 pacientes (12m, 5f com idades que variaram de 1 a 24 anos (mediana 6 anos com distrofia muscular congênita (DMC, que foram estudados do ponto de vista genético, clínico, laboratorial, eletrofisiológico e anátomo-patológico. A apresentação segundo a herança foi da forma esporádica (76,5% ou possivelmente autossômica recessiva (23,5%. A diminuição da movimentação fetal intra-uterina foi referida em 57% dos casos, hipotonia neonatal em 82% e retardo no desenvolvimento motor em 88,2%. Fraqueza muscular, diminuição dos reflexos profundos e contraturas articulares estavam presentes em todos os casos. A piora na função motora estava muito relacionada ao aumento ou aparecimento de novas retrações articulares. A CK nunca ultrapassou valores acima de 8 vezes o normal. O ENMG foi de padrão miopático em 73,3%, neuropático em 13,3% e normal em 13,3% dos casos. Aspectos tomográficos com hipodensidade da substância branca subcortical foram vistos em 8 casos. Ao tratamento impôs-se fisioterapia adequada e cirurgia corretiva das deformidades articulares. Novas contraturas desenvolveram-se mais tarde e estavam relacionadas freqüentemente a fisioterapia insuficiente.

  14. Adrenoleucodistrofia (leucodistrofia melanodermica: registro de um caso anatomo-clinico

    Directory of Open Access Journals (Sweden)

    Mario Wilson Iervolino Brotto

    1979-06-01

    Full Text Available É relatado o caso de um paciente de 14 anos, do sexo masculino, com esclerose cerebral difusa precedida em 7 anos de sinais de insuficiência do córtex supra-renal, com antecedentes familiares. Clinicamente a doença é caracterizada por deterioração mental, distúrbios da marcha e da visão, associados com insuficiência do córtex supra-renal. Confirmando os dados da literatura, em nosso caso o estudo anátomo-patológico revelou desmielinização e gliose difusa na substância branca cerebral, poupando as fibras subcorticais. Células inflamatórias são comuns e têm distribuição perivascular. Na zona fasciculada e reticular da supra-renal, células "balonadas" são evidentes, muitas delas apresentando citoplasma vacuolizado e com estriações. Inclusões lipídicas similares têm sido encontradas nas células de Schwann dos nervos periféricos e dos testículos. Os achados são comparados com vinte casos da literatura.

  15. Angiomyolipoma of the kidney: Clinico pathological and immunohistochemical study

    International Nuclear Information System (INIS)

    Esheba, Gh.E.; Esheba, N.E.

    2013-01-01

    Overview: Although angiomyolipoma (AML) is a relatively rare entity, it is the most common benign mesenchymal neoplasm of the kidney. The aim of this study: To highlight the clinicopathological characteristics of AML and to assess the role of Human Melanoma Black-45 (HMB-45), Melan-A, smooth muscle actin (SMA), S-100 and cytokeratin in its diagnosis. Materials and methods: The study included 15 cases of AML. Clinical and radiological data were retrieved from the archival files and all cases were subjected to a histopathological evaluation as well as immunohistochemical staining for HMB-45, Melan-A, SMA, S-100, and cytokeratin. Results: AML was more common in females (female:male = 4:1), the mean age was 53.9 ± 6.45 years. 60% of patients were symptomatic while the remaining 40% were asymptomatic. A statistically significant relationship was found between size of the tumor and the presence of the symptoms (P = 0.02). Patients with tumor size less than 4 cm were asymptomatic, while those with tumor size larger than 4 cm had different symptoms. Thirteen cases were classic AML, while 2 cases were epithelioid AML. Classic AML demonstrated admixture of fatty tissue, thick-walled blood vessels, and smooth muscle, while epithelioid AML was composed mainly of epithelioid cells and contained no fat. HMB-45 was positive in all cases of AML (100%), Melan-A was positive in 13/15 (87%) while SMA was positive in 11/15 (73%) of AML with variable staining intensity. All cases of AML were negative for S-100 and cytokeratin. Conclusion: AMLs have characteristic clinicopathological and immunohistochemical features and their recognition is crucial for proper diagnosis and treatment

  16. Clinico-pathological characteristics of cervical cancer in Ghanaian

    African Journals Online (AJOL)

    User

    This study found high prevalence of cervical cancer among female geni- tal tract cancers in Accra Ghana. ..... (serotypes 16, 18, 33, 35, 45) of human papilloma- virus (HPV), that are known to cause the condition and the high prevalence of HIV ...

  17. CLINICO-THERAPEUTIC STUDIES ON CANINE TRANSMISSIBLE VENEREAL TUMOUR

    Directory of Open Access Journals (Sweden)

    M. Athar, A. Suhail, G. uhammad, A. Shakoor and F. Azim

    2001-01-01

    Full Text Available Ten-bitches and 8-male dogs afflicted with transmissible venereal tumour (TVT randomly divided into 3 groups viz. Group-I, Group-II and Group-III comprising 6 dogs each, were subjected to three different protocols. Group-I was treated surgically. A complete regression of the tumour mass was observed in 4 (66.67% dogs, while 2 (33.34% had incomplete regression at the end of first 5 weeks. A 16.67% recurrence rate was also observed at the end of 6 months study period. In Group-III, chemotherapy with intravenous injection of vincristine sulphate @ 0.025 mg/kg b.wt. affected 80.33% (n=5 complete regression whereas incomplete regression was recorded in only one (16.67% subject at the end of 5th week. Vomiting and inappetance as side-effects were also noticed. Group-III was subjected to a combination of surgery and chemotherapy where vincristine sulphate was used after surgical debulking of tumour mass. A 100% regression even after 2-3 injections with no recurrence was achieved till 6 months post-treatment. There was a significant increase (P≤0.01 in erythrocyte sedimentation rate and total leukocyte count (TLC in TVT -afflicted dogs which returned to normal after 2-5 weeks of treatment. Vincristine sulphate had a significant decreasing effect on TLC in both Group-II and Group-III, which was transient.

  18. Macrodystrophia lipomatosa: Review of clinico-radio-histopathological features

    Directory of Open Access Journals (Sweden)

    Banashree Majumdar

    2016-01-01

    Full Text Available We report clinical, radiological, and pathological features of three cases of macrodystrophia lipomatosa, which is characterized by progressive proliferation of all mesenchymal elements, with a disproportionate increase in fibroadipose tissue. The peculiarity in our report is the involvement of contralateral hand and feet in our 1st case in contrast to usual presentations of this rare condition, which is often unilateral. In our 2nd case, the lateral aspect of foot was involved as against the usual finding of involvement of medial aspect in lower limbs, also another surprising finding in this case is increase in the size of lesion after puberty. Coming to our 3rd case, enlargement of almost whole of an upper extremity with profound involvement of middle, ring and little finger along with total sparing of the thumb is in itself an extremely rare occurrence as in upper limb, mainly the lateral aspect of hand and related digits bear the burnt and more over involvement of whole limb is itself an unique phenomenon.

  19. [Acute appendicitis: clinico-diagnostic and therapeutic considerations].

    Science.gov (United States)

    Carditello, A; Bartolotta, M; Bonavita, G; Lentini, B; Sturniolo, G

    1985-04-01

    Since january 1970-december 1982, 58 patients underwent emergently appendectomy for acute appendicitis. 31 (53,4 percent) where males; the average age was 21 +/- 2,3 years (M +/- SEM). The duration of symptoms ranged from 1-6 hours (10,3 percent of cases) to over 48 hours, before the hospital admission (15,4 percent of cases). 27 patients (46,5 percent) had a clinical examination at home by a physician. 21 patients (36,4 percent) came to hospital emergency unit without previous physical examination; 10 (17,2 percent) were transferred from other departments. In 6,9 percent of cases was present a perforated appendicitis with peritonitis. During operation, in 50 percent of patients was performed a therapeutic peritoneal lavage. In 63,7 percent of cases multiple drains were placed in peritoneal cavity. In all patients was effected postoperative antibiotic profilaxis. The mortality rate was 3,4 percent. General complications were observed more in patients with perforated appendicitis. This review suggests the following remarcable data: morbidity of this disease is still high; the physical examination is more important than laboratory work (especially in the elderly patients, which are often immunodepressed and in children, with leucocitosis-lack at hospital admission); early surgery is the most important factor to the improvement of prognosis in these cases and the results of surgical treatment are improved by large vertical incisions, peritoneal lavage and application of multiple intracavitary drains.

  20. Clinico-pathological pattern of nasopharyngeal carcinoma in Ilorin ...

    African Journals Online (AJOL)

    There were 20 males and 10 females with a mean age of 48.7 ± 15.9 years. The commonest presenting complaint was cervical lymphadenopathy in 96.7% of patients followed by epistaxis (66.7%) and hearing loss (66.7%). Identifiable risk factors included regular intake of ungutted salted smoked fish (76.7%) and tobacco ...

  1. Clinico-anatomical correlations of left posterior cerebral artery occlusion

    International Nuclear Information System (INIS)

    Isono, Osamu; Shiota, Junichi; Kawamura, Mitsuru; Hirayama, Keizou; Maki, Toshiyuki.

    1988-01-01

    The relation between neurological signs and symptoms and computed tomography (CT) and magnetic resonance imaging (MRI) was examined in 11 cases of occlusion of the left posterior cerebral artery. All the patients were righthanded. Right homonimous hemianopia was noted in 8 cases, right upper quadrantanopia in 2 cases, and right lower quadrantanopia in 1 case. Of the 11 cases, alexia without agraphia was noted in 9 cases, all 9 of which showed lesions of inferior occipital cortex (lingual and fusiform gyri) and subjacent white matter. Lesions of splenium were found in only 5 of the cases of alexia without agraphia. In 2 cases with neither alexia nor agraphia, lesions were seen in the medial occipital cortex and the subjacent white matter but not in the inferior occipital lobe. Three patients had color anomia which was accompanied by memory disturbances and alexia without agraphia. In 2 of these 3, lesions were widespread in the region of the left posterior cerebral artery. Memory disturbances were observed in 6 cases, all of which also showed alexia without agraphia. The lesions extended not only of the inferior surface of the occipital lobe and along the interhemispheric fissure, but also of hippocampal and parahippocampal gyri. In 3 cases of alexia without agraphia in which no memory distrubance was found, the symptoms of alexia were slight and disappeared at an early stage. (J.P.N.)

  2. Clinico-pathological evaluation of two patients presenting with the ...

    African Journals Online (AJOL)

    The discovery of the Aquaporin 4 (AQP4) antibody in patients with neuromyelitis optica (NMO) has expanded clinical spectrum of disorders associated with this antibody. It has also become clear that NMO can be a paraneoplastic manifestation of an underlying malignancy. We report on the pathological changes in the ...

  3. HIV in females: A clinico-epidemiological study

    Directory of Open Access Journals (Sweden)

    Mahesha Padyana

    2013-01-01

    Full Text Available Background: Human Immunodeficiency Virusinfected women account for almost half the number of cases of HIV worldwide. Despite reduction in HIV prevalence among the population, the percentage of Indian women contracting the disease seems to have increased. The social implications are also different in females. Materials and Methods: This prospective observational study was conducted from September 2009 to July 2011 at tertiary care hospitals attached to the Kasturba Medical College Mangalore, on a group of 200 HIV-positive patients. Patients above 18 years of age diagnosed with HIV as per National AIDS Control Organisation guidelines were included in the study. Clinical profile among women and men was compared with respect to clinical presentation, disease detection, CD4 count and response of family and society. Results: Clinical presentation was similar among both men and women. Eighty-one percent men had promiscual sexual exposure, 19% of women had so. Males were identified to be HIV-positive earlier than their spouse (tested later, time lag being 27.6 weeks. After detection of positivity 77% of females felt being less cared for by the in-laws. CD4 count less than 50 was detected in more number of females as compared to men (11% females and 1% males. Death of spouse was seen more often in females (among 35% of women and 11% of men. Conclusion: Most of the females were likely to acquire infection from their spouse. Females tend to seek and get medical attention at the late stage of disease as compared to men. HIV in females has different social implications which includes discrimination within the family.

  4. CLINICO PATHOLOGICAL STUDY OF PATTERNS OF ANEMIA DURING PREGNANCY

    Directory of Open Access Journals (Sweden)

    Chamakuri

    2015-10-01

    Full Text Available INTRODUCTION: Anemia is defined as haemoglobin level in the blood below the lower extreme of the normal range for the age and sex of the individual. According to WHO, in developing countries the prevalence of anemia among pregnant women averages 60%, ranging between 35 to 100% among different regions of the world. A hemoglobin concentration below 11.0g/dl or packed cell volume (PCV of less than 33.0% is regarded as anemia during pregnancy by the WHO. It occurs in 40 - 80% of the pregnant women. Iron and folic acid defici encies, malaria, intestinal parasitic infections and hemoglobinopathies are the principal causes of anemia in pregnancy. Predisposing factors include young age, grand multiparity, low socioeconomic status, illiteracy, ignorance and short intervals of pregn ancy. AIM AND OBJECTIVES: 1. To study various patterns of anemia in pregnant women having haemoglobin level < 11 gm%. 2. To determine the most common pattern of anemia in pregnancy based on red cell morphology. MATERIALS AND METHODS: This study is a prospe ctive study over a period of one year from September 2014 to August 2015 in the department of pathology, Andhra medical college, Visakhapatnam . The study was conducted on 120 pregnant women whose haemoglobin level is < 11 gm/dl. All the haemotological parameters & peripheral blood smear stained by Leishman’s stain were evaluated. Complete clinical & obstetric history was recorded. Socioeconomic status was also noted. RESULTS: Out of 120 cases of anemia, we found 47 patie nts (39.1% having dimorphic anemia, 36(30% – microcytic hypochromic anemia, 23(19.1% - normocytic hypochromic anemia, 11(9.16% - sickle cell anemia and 1(0.83% case of pancytopenia. Maximum cases were seen in the age group of 21 - 30 years. 52 cases (43. 3% were primigravida and remaining 68 cases (56.6% were gravida two to four. 20 cases (16.6% were diagnosed in the first trimester, 38 cases (31.6% in the second trimester & 62 cases (51.6s% in the third trimester. CONCLUSION: In conclusion, the commo n morphological patterns of anemia in this study are dimorphic anemia and microcytic hypochromic anemia. More common in the multigravida & in the third trimester of pregnancy. After the 1 st trimester there is increased fetal demand & hemodilution effect an d thus anemia occurs commonly in this period. The risk factors for anemia in this study are low socioeconomic status, multiparity & H/O complications during previous pregnancy. The socioeconomic conditions must be improved, early detection & good antenatal care to be provided for the prevention of anemia in pregnancy

  5. Aspectos virológicos e clínico-patológicos da infecção genital aguda e latente pelo herpesvírus bovino tipo 1.2 em bezerras infectadas experimentalmente Virological and clinico-pathological features of acute vulvovaginitis and latent infection by bovine herpesvirus 1.2 in heifers experimentally infected

    Directory of Open Access Journals (Sweden)

    Andréia Henzel

    2008-03-01

    and cows with bovine herpesvirus type 1.2 (BoHV-1.2 may result in vulvovaginitis and transient infertility. The acute infection is followed by the establishment of latent infection which can be periodically reactivated. We herein describe the virology and clinico-pathological aspects of acute and recrudescent vulvovaginitis in heifers inoculated with a Brazilian BoHV-1.2 isolate recovered from an outbreak of balanoposthitis. Genital inoculation of isolate SV-56/90 (10(8.1TCID50/animal in four eight-months-old heifers resulted in efficient virus replication in the genital mucosa and the development of moderate to severe vulvovaginitis. The inoculated heifers shed virus in genital secretions in titers up to 10(7.3TCID50/mL until day 10 pi and developed genital congestion, swelling, vesicles and pustules. The vesicles and pustules increased in size eventually coalesced and became covered with a yellowish exsudate. These signs appeared at day 2 pi, increased in severity up to days 5 - 8 pi and progressively subsided thereafter. Dexamethasone administration at day 55 pi resulted in virus shedding in vaginal secretions for up to 10 days. Virus reactivation in all animals was accompanied by clinical recrudescence of the disease, yet less severe than during acute infection. Examination of sacral ganglia and lymph nodes by PCR at day 36 post-reactivation revealed the presence of latent viral DNA in the pudendal (4/4, genito-femoral, sciatic and rectal caudal (3/4 and obturator nerve ganglia (1/4; in addition to several regional lymph nodes. These results demonstrate the virulence of isolate SV-56/90 for heifers and pave the way for its use in further pathogenesis studies and vaccine-challenge trials.

  6. Hyperlucent lung; Pulmon hiperlucente

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez-Gutierrez, Florana; Soto-Quiros, Manuel E [Hospital Nacional de Ninos, Servicio de Neumologia, apartado 1654-1000, San Jose (Costa Rica)

    2007-10-15

    infecciones de vias respiratorias bajas a repeticion, desde los primeros anos de vida y los que presentan disnea de esfuerzo. El diagnostico se suele realizar como un hallazgo incidental al hacer una radiografia de torax a un nino por infecciones respiratorias repetidas, o en la edad adulta en una exploracion radiologica de rutina, en una persona por lo demas asintomatica. Es importante diferenciar este sindrome de otras causas de hiperclaridad pulmonar unilateral en las radiografias de torax convencionales. Pocos casos del Sindrome Swyer-James han sido reportados en ninos. Se presenta el caso clinico de un paciente quien tuvo una bronconeomonia parainfluenza 3 al mes y 18 dias de edad. El diagnostico diferencial de este sindrome se debe hacer con otras entidades toracicas que disminuyen la densidad radiologica pulmonar unilateral. Se describe el caso clinico de un nino que es portador de pulmon hiperlucente. (autor)

  7. Blended learning specialists in radiation protection; Formacion semipresencial de especialistas en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Mayo, P.; Campayo, J. M.; Verdu, G.

    2011-07-01

    In this paper, we present a blended learning Radiation Protection Technician through an approved degree from the Polytechnic University of Valencia, which covers the knowledge and skills of functions relating to operators and supervisors in various areas and skilled workers to be to perform their work in technical units or Radiation Protection Radiation Protection Services. The benefits of this work are those related to achieving quality training flexible and adapted to follow the check off the person conducting the course, adapted to internal and external training of the applicant companies.

  8. Design an online course of radiological protection; Diseno de un curso en linea de proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Garcia S, R.; Del Sol F, S.; Rivera M, T.; Sanchez G, D., E-mail: rigarcias@ipn.mx [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria No. 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico)

    2015-10-15

    Currently there is a vast research about the harmful effects of the use of ionizing radiation in medical procedures and in recent years struck by the rapid innovation in imaging equipment, considerably increasing the radiation dose received both patients and professionals in the radiodiagnosis area, service having the greatest demand in our country. The main strategy that has so far is education, that is, to inform all those involved in managing ionizing radiation about the applications and risks associated with them. Generally it requires that all personnel occupationally exposed attesting a course of radiation protection. However, the high demand for this type of medical services and poorly trained staff, makes taking a classroom course for personnel occupationally exposed is complicated. So that in the Instituto Politecnico Nacional (IPN) we are designing a course in radiation protection to be implemented online, through the virtual platform Moodle in a first stage, and a massive open online course as the second stage so that can be carried by anyone interested in the subject, without having to appear in person. This will allows to reach the largest possible number of personnel occupationally exposed to just have a computer with internet access. (Author)

  9. Second level courses in radiation protection training; Cursos de segundo nivel de formacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Ribas, M.; Vanom, E.; Alonso, M.; Arranz, L.; Cordoba, D.; Ferrer, N.; Gomez, A.; Hernandez Armas, P.; Plallares, L.; Pombar, M. A.; Rubio, A.; Tellez de Cepeda, M.

    2011-07-01

    The aim of this paper is to present as being carried out the implementation of this standard in Spain by conducting specific courses, following the guide 116 of the Radiation Protection Commission, and the degree of acceptance of same among physicians who perform it.

  10. The regulation of the radiological protection in Mexico; La reglamentacion de la proteccion radiologica en Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Eibenschutz H, J. [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Jose Ma. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2008-12-15

    The regulation antecedents in nuclear question in Mexico are placed in 1950, with the promulgation of {sup L}aw that declares national mining reserves the uranium deposits, thorium and the other substances of which obtains fissionable isotopes that can produce nuclear energy{sup ,} instrument that stipulated the control of uranium, thorium, as to its it indicated it name, and other fissionable substances, on the part of the state, although they were without a doubt the respective institutions, the National Commission of Nuclear Energy in 1955, and the one of the National Commission of Nuclear Safety and Safeguards (CNSNS) in 1979, those that allowed the development of a prescribed frame in the nuclear and radiological areas. One characteristic of the regulation in radiological protection is the variety in the authorities type that have incidence in the regulation, as a result of the different approaches with which it can be approached. For example, in Mexico normative instruments with content in radiological protection exist and are watched over the Health Secretary, who is oriented to the protection of the patient, their relatives and the medical body; Work and Social Welfare Secretary, with a labor approach; Communications and Transport Secretary, which regulates the transport of nuclear and radioactive materials; Finance and Public Credit Secretary, who regulates the import and export of radioactive materials; Environment and Natural Resources Secretary, which regulates the environment protection; Energy Secretary who has responsibilities inside of the {sup p}rescribed law of article 27 constitutional in nuclear matter{sup ;} and within the energy sector, the CNSNS that expedite and watch the fulfillment of normative in radiological protection and nuclear safety. In order to resist effects of on regulation; frequently inter institutional agreements are carried out in which the areas of monitoring are agreed by each authority. The regulation in radiological protection demands the attention in all the involved subjects, like for example the patient protection. The prescribed experience in Mexico indicates that the involved authorities only must demand faculties for whose fulfillment they have all the necessary resources, or on the contrary to guarantee that it was counted on the same. Also it is necessary to understand that when there are overlap of functions in the regulation must need to be a complete coordination between the involved authorities. (Author)

  11. Characteristics of radiation protection legislation; Caracteristicas de la legislacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Puig Cardozo, Diva E. [Ministerio de Industria, Energia y Mineria (MIEM), Montevideo (Uruguay). Direccion Nacional de Tecnologia Nuclear

    2001-07-01

    The laws on radiological protection have special characteristics. They can exist laws that regulate dangerous activities that will be also applicable, if it corresponds to the activities that involve radioactive materials. But a law of radiological protection should exist. It foresees the existence of an appropriate regulatory body and specialized institutions, definitions, infractions and sanctions then the respective regulations will be elaborated for the different applications. The objective is to contribute to the development of the nuclear energy in the country and to provide the regulatory basis that assures a reasonable security for radioactive installations. The essential objectives of these laws are: 1. to establish the legislative framework for the development and employment of nuclear energy, without risks, according with treaties and conventions that the countries have approved. 2. To fix the fundamental principles and the conditions of their setting in practice allowing to a specific regulation determining application procedures. 3. To create a structure of regulation of enough authority to be able to control and to watch over in an effective way the authorized activities 4. To guarantee an appropriate financial protection against the derived damages of accidents or nuclear incidents. (author)

  12. Radiation protection in large linear accelerators; Seguranca radiologica de aceleradores lineares de grande porte

    Energy Technology Data Exchange (ETDEWEB)

    Oliva, Jose de Jesus Rivero, E-mail: rivero@con.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Departamento de Engenharia Nuclear; Sousa, Fernando Nuno Carneiro de, E-mail: fernandonunosousa@gmail.com [Aceletron Irradiacao lndustrial, Rio de Janeiro, RJ (Brazil)

    2013-07-01

    The electron linear accelerators can be used in industrial applications that require powerful sources of ionizing radiation. They have the important characteristic of not representing a radiation hazard when the accelerators remain electrically disconnected. With the plant in operation, a high reliability defense in depth reduces the risk of radiological accidents to extremely small levels. It is practically impossible that a person could enter into the radiation bunker with the accelerators connected. Aceletron Irradiacao Industrial, located in Rio de Janeiro, offers services of irradiation by means of two powerful electron linear accelerators, with 15 kW power and 10 MeV electron energy. Despite the high level of existing radiation safety, a simplified risk study is underway to identify possible sequences of radiological accidents. The study is based on the combined application of the event and fault trees techniques. Preliminary results confirm that there is a very small risk of entering into the irradiation bunker with the accelerators in operation, but the risk of an operator entering into the bunker during a process interruption and remaining there without notice after the accelerators were restarted may be considerably larger. Based on these results the Company is considering alternatives to reduce the likelihood of human error of this type that could lead to a radiological accident. The paper describes the defense in depth of the irradiation process in Aceletron Irradiacao Industrial, as well as the models and preliminary results of the ongoing risk analysis, including the additional safety measures which are being evaluated. (author)

  13. Radiation Safety in Industrial Radiography. Specific Safety Guide (Spanish Edition); Seguridad radiologica en la radiografia industrial

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-12-15

    This Safety Guide provides recommendations for ensuring radiation safety in industrial radiography used in non-destructive testing. This includes industrial radiography work that utilizes X ray and gamma sources, both in shielded facilities that have effective engineering controls and in outside shielded facilities using mobile sources. Contents: 1. Introduction; 2. Duties and responsibilities; 3. Safety assessment; 4. Radiation protection programme; 5. Training and qualification; 6. Individual monitoring of workers; 7. Workplace monitoring; 8. Control of radioactive sources; 9. Safety of industrial radiography sources and exposure devices; 10. Radiography in shielded enclosures; 11. Site radiography; 12. Transport of radioactive sources; 13. Emergency preparedness and response; Appendix: IAEA categorization of radioactive sources; Annex I: Example safety assessment; Annex II: Overview of industrial radiography sources and equipment; Annex III: Examples of accidents in industrial radiography.

  14. Radiation protection in medical centers : teletherapy service; Proteccion radiologica en centros hospitalarios : servicio de teleterapia

    Energy Technology Data Exchange (ETDEWEB)

    Resendiz G, G.; Perez P, M.; Figueroa M, E. [Clinica Medica Sur, Servicio de Radioterapia, Puente de Piedra No. 150, Col. Toriello Guerra, Mexico 14050 D. F. (Mexico)

    2008-12-15

    The General Regulation of Radiation Safety, it clearly provides the classification, requirements and obligations of the various figures relating to a radiation protection system, i.e., the occupationally exposed personnel, the radiation safety responsible, the legal representative, the type of installation, etc. For new installations, the shieldings calculation should be contained in the analytical report with due consideration of factors, such as those surrounding the areas classification based on the occupation type, the work load of the equipment and others. The operation license involves requirements such as the Report and the Radiation Safety Handbook, the Emergencies Plan, the establishment of register levels, investigation and intervention, the way it is carried out medical surveillance of the occupationally exposed personnel, and the description of the protection mechanisms and detection instrumentation and radiation measurement. Deserves mention the case when high readings are recorded in the personal dosimeters, which must submit to an interrogation to the employee, you must determine if it is an incorrect reading to the service provider, you must perform a medical exam blood cell count with relevant to the dose determination, may eventually can lead to a cytogenetic study and the determination to do if confirmed an unexpectedly high dose. Moreover, the technology evolution also implies the development of adaptation measures. For example, the Intensity Modulated Radiation Therapy, which is an advanced high-precision radiotherapy that uses X-ray accelerators for computer-controlled radiation doses precisely to a malignant tumor or specific areas within the tumor, taking into account requires regard to equipment, and space and shielding, time and staff hours for treatment, personnel training, materials for making images (such as two-dimensional arrangements of integrated circuits or diodes, films or portal images), the attention given by the engineers of service, the validation of the treatment plan and quality control of the planning system and dosimetry parameters and mechanics. (Author)

  15. Radiological Protection Service of CN Asco; Servicio de ProteccionRadiologica de C. N. Asco

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-07-01

    Briefly explains the structure of Radiation Protection Service (SPR) of CN Asco to address these performances, as well as a short description of the main activities that have been reinforced or have been incorporated into the routine activities of the SPR. (Author)

  16. Radiological emergencies and the ARCAL project; Emergencias radiologicas y el rol del proyecto ARCAL

    Energy Technology Data Exchange (ETDEWEB)

    Gironzini, Eduardo Medina [Instituto Peruano de Energia Nuclear, Lima (Peru)

    1997-12-31

    The ARCAL project and its purpose are described. The project has started on 1985 and assembles the Latin American countries in a concentrate effort to develop and to strengthen activities of radiological protection in technical cooperation with the IAEA. Radiological emergency is a high important subject in all the projects developed by ARCAL. The ARCAL activities are briefly presented, such as: meetings, training courses, seminars, dissemination of information, preparing of technical documents, books, etc. The role of ARCAL in the field of radiological emergency is discussed 6 refs.; e-mail: congres at ciplim.org.pe

  17. Radiation emergency planning for medical organizations; Plan de emergencia radiologica en entidades de salud

    Energy Technology Data Exchange (ETDEWEB)

    Jerez Vergueria, Sergio F. [Instituto de Medicina del Trabajo, La Habana (Cuba); Jerez Vergueria, Pablo F. [Centro Nacional de Seguridad Nuclear, La Habana (Cuba)

    1997-12-31

    The possible occurrence of accidents involving sources of ionizing radiation demands response plans to mitigate the consequences of radiological accidents. This paper offers orientations in order to elaborate emergency planning for institutions with medical applications of ionizing radiation. Taking into account that the prevention of accidents is of prime importance in dealing with radioactive materials and others sources of ionizing radiation, such as X-rays, it is recommended that one include in emergency instructions and procedures several aspects relative to causes which originate these radiological events. Topics such as identification of radiological events in these practices and their consequences, protective measures, planning for and emergency response and maintenance of emergency capacity, are considered in this article. (author) 16 refs., 1 tab.; e-mail: sfjerez at rdc.puc-rio.br

  18. Diagnosis of radiological security of installations; Diagnostico de la seguridad radiologica de instalaciones

    Energy Technology Data Exchange (ETDEWEB)

    Herrera V, L [Laboratorio de Vigilancia Radiologica Ambiental, Gerencia de Seguridad del ININ (Mexico)

    1991-07-01

    The objective of this work is to discuss the diagnosis of the radiological safety of nuclear or radioactive facilities. It was concluded that the one diagnoses like discipline of the radiological safety is susceptible of being represented, taught and programmable in computer and useful systems as preventive tool and of inspection.

  19. Radiological protection and environmental management; La proteccion radiologica y la gestion ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Perez Fonseca, A.

    2010-07-01

    From the beginning of its industrial activity twenty five years ago, the Juzbado Factory of Enusa Group has always upheld a strong commitment with Radiological Protection and environmental respect and protection. Consequently, the evolution of dose shows a downward trend over the years. Although production has been increased gradually, the average doses to workers have stayed below 1 mSv. In order to identify and prevent the potential environmental impacts of its industrial activity and minimize its impact on the surroundings, the facility develops and environmental management system according to UNE-EN-ISO 14001 since 1999. (Author)

  20. Radiological evaluation of the cranio vertebral junction; Avaliacao radiologica da transicao cranio-vertebral

    Energy Technology Data Exchange (ETDEWEB)

    Mello, Silvia Marcal Benicio de; Haetinger, Rainer Guilherme [Med Imagem - Beneficiencia Portuguesa de Sao Paulo, SP (Brazil). Setor de Cabeca e Pescoco]. E-mail: sbm@uol.com.br; Schettini, Marianna Cunha; Lima, Sergio Santos [Med Imagem - Beneficiencia Portuguesa de Sao Paulo, SP (Brazil); Mourao, Maria Lucia; Mendonca, Renato Adam [Med Imagem - Beneficiencia Portuguesa de Sao Paulo, SP (Brazil). Setor de Neuroradiologia

    2005-04-15

    The cranio vertebral junction (CVJ) comprises the occiput, atlas, their joints and ligaments. Besides conventional x-rays other imaging methods are need for the assessment of CVJ including high resolution computerized tomography (CT) and magnetic resonance imaging (MRI) which provide specific parameters such as field of view, slice thickness and incremental movement of the patient. A dynamic study is also important to assess the stability of the cranio vertebral junction and the effect upon the bulbomedullary junction. The aim of this study is to review the techniques used in the evaluation of the CVJ, the semiological parameters, and the most frequent disorders affecting this region. We review the literature and present conventional x-ray, CT and MRI images from the didactic file of the Radiology service 'Med Imagem - Beneficiencia Portuguesa de Sao Paulo, SP, Brazil, of cases with normal anatomy and the main congenital and acquired disorders of the CVJ. In daily practice, CVJ disorders are diagnoses using CT and MRI scans of the head and cervical spine. It is essential to be familiar with these conditions in order to preform specific tests which will allow a detailed study of the CVJ, thus providing the basis for the treatment, whenever indicated. (author)

  1. Research and development in radiological protection; Investigacion y desarrollo en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Butragueno, J. L.; Villota, C.; Gutierrez, C.; Rodriguez, A.

    2004-07-01

    The objective of Radiological Protection is to gurantee that neither people, be they workers or members of the public, or the environment are exposed to radiological risks considered by society to be unacceptable. Among the various resources available to meet this objective is Research and Development (R and D), which is carried out in three areas: I. Radiological protection of persons: (a) knowledge of the biological effects of radiations, in order to determine the relationship that exists between radiation exposure dose and its effects on health; (b) the development of new personal dosimetry techniques in order to adapt to new situations, instrumental techniques and information managmenet technologies allowing for better assessment of exposure dose; and (c) development of the principle of radiological protection optimisation (ALARA), which has been set up internationally as the fundamental principle on which radiological protection interventions are based. II. Assessment of environmental radiological impact, the objective of which is to assess the nature and magnitude of situations of exposure to ionising radiations as a result of the controlled or uncontrolled release of radioactive material to the environment, and III.Reduction of the radiological impact of radioactive wastes, the objective of which is to develop radioactive material and waste management techniques suitable for each situation, in order to reduce the risks assocaited with their definitive managmenet or thier release to the environment. Briefly desribed below are the strategic lines of R and D of the CSN, the Electricity Industry, Ciemat and Enresa in the aforementioned areas. (Author)

  2. Radiological findings of pulmonary Kaposi's sarcoma. Manifestaciones radiologicas del sarcoma de Kaposi pulmonar

    Energy Technology Data Exchange (ETDEWEB)

    Rosello, J A; Hernandez, S; Arranz, M; Jareo, J; Ancoechea, J

    1994-01-01

    Kaposi's sarcoma (KS) is the most common neoplasm in AIDS patients. The incidence of pulmonary involvement is approximately 20%. The radiological findings are reported in plain chest x-ray and computed tomography (CT) in 15 patients diagnosed as having pulmonary Kaposi's sarcoma, in whom concomitant pulmonary infection was ruled out. The most common radiological pattern was that of bilateral perihilar interstitial involvement (86%), while poorly defined multiple nodules seldom presented (13%). In 40% of cases, the pulmonary parenchymal lesion was accompanied by pleural effusion. This sign is useful in the differential diagnosis involving opportunistic P. carinii pneumonia, a very common process in these patients which rarely presents with pleural effusion. The chest CT finding that was most characteristic of pulmonary Kaposi's sarcoma was bilateral perihilar peribronchovascular enlargement. (Author)

  3. Environmental monitoring networks in Spain; Redes de vigilancia radiologica ambiental en Espana

    Energy Technology Data Exchange (ETDEWEB)

    Luque Heredia, S.; Martin Matarranz, J. L.; Marugan Tovar, I.; Rey del Castillo, C.; Salas Collantes, R.; Sterling Carmona, A.; Ramos Salvador, L. M.

    2011-07-01

    Environmental monitoring in Spain is carried out by several networks with different objectives and scope, a monitoring network in the vicinity of nuclear facilities and radioactive nuclear fuel cycle and various monitoring networks nationally funded and managed by agencies public. The aim of this paper is to present a summary of all monitoring networks, including a series of figures with the stations that are, their geographical distribution and the programs in them.

  4. Radiologic protection in intensive therapy units; Protecao radiologica em unidades de terapia intensiva

    Energy Technology Data Exchange (ETDEWEB)

    Andrea, H.; Juliana, C.; Gerusa, R.; Laurete, M.B.; Suelen, S., E-mail: andrea.huhn@ifsc.edu.br, E-mail: juliana@ifsc.edu.br, E-mail: gerusa@ifsc.edu.br, E-mail: laurete@ifsc.edu.br, E-mail: suelen.saraiva@ifsc.edu.br [Instituto Federal de Santa Catarina (IFSC), Florianopolis, SC (Brazil); Derech, Rodrigo D.A., E-mail: dagostiniderech@gmail.com [Policlinica Municipal Sul, Florianopolis, SC (Brazil)

    2013-11-01

    The discovery of X-ray was a great achievement for humanity, especially for the medical community. In Intensive Care Units (ICUs), the RX tests, performed with mobile devices, add immense value to the diagnosis of inpatients who do not have the option to carry them out of bed. Following the technology and its improvements, fatalities arose from misuse of ionizing radiation, which mostly gave up for lack of knowledge of the biological effects caused by them, which leads to fear among professionals and often prevents a quick job and effectively by professionals of radiological techniques. The research it is a systematic review of the literature and justified by the scarcity of materials that reflect on the radiological protection in ICUs. For this study we found the Virtual Health Library (VHL) and Pubmed were indexed terms radiological protection and intensive care units, the search in Portuguese and English terms were used radiological protection and intensive care unit. The study aims to inform professionals of ICUs on the main aspects that refer to X-rays in hospital beds, the standards of radiological protection and personal protective equipment, thus avoiding possible damage to the biological health of workers, addressing subjects in rules and laws about the X radiation, emphasizing the protection of professionals in intensive care. It is clear, finally, that little research is conducted in the context of radiological protection of workers ICU's and this is a place that receives daily RX equipment, deserving more attention to protect the worker. (author)

  5. Radioprotection of the patient in nuclear medicine; Proteccion radiologica del paciente en medicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Perez, Maria del R [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina)

    2004-07-01

    The following topics are developed: concepts on radioprotection; stochastic and deterministic effects; the prenatal irradiation; different types of radiation exposition (medical, occupational and public irradiation); and the justification of the levels of radiation.

  6. The radiological protection in the radiotherapy; La proteccion radiologica en la radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Castaneda M, A.; Gonzalez N, A. G. [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2010-09-15

    The cancer incidence in the world has been increased with the course of the time. Fifty percent of the patients receive radiotherapy, as much in the initial treatment, as in the recurrence cases or palliatives. At the moment is considered that in 1998 there were 2,500 teletherapy machines in operation in the countries in development and for the year 2015 will be necessary 10,000. In Mexico the use of these teletherapy units goes back to the year of 1956, when the effort of the Dr. Noriega Limon was consolidated with the installation of the first teletherapy unit with a cobalt 60 source in the National Medical Center of the IMSS. In the same decade the operation began of the Calibration Secondary Center located in the facilities of the General Hospital of Assistance and Health Secretary where a group of seven physicists began in the metrology techniques. Also the national authority in matter of the ionizing radiations use appears and promulgates the first Law in Nuclear Matter. The application has extended in the country, as well as other techniques that have gone incorporating for the cancer treatment. Such as: the brachytherapy, the stereo ataxia and the ophthalmic applicators. In the current application of the radiotherapy several factors are interrelated that have for objective that the dose to the workers and the public is as low as reasonably it can be achieved and that the patient receives the dose prescribed by the medical treatable in the organ or tissue and in the orderly quantity with the minor damage for the healthy tissues. To reach all this, it is necessary to have equipment s, systems, procedures, personal and standards that improve their quality in a gradual but firm way, also the good communication and comprehension among authorities are fundamental for this noble task. (Author)

  7. Radiological protection in studies of interventionist fluoroscopy; Proteccion radiologica en estudios de fluoroscopia intervencionista

    Energy Technology Data Exchange (ETDEWEB)

    Juarez R, K.M

    2004-07-01

    The main objective of this study is to determine, if it is necessary or not, to establish appropriate additional procedures of radiological protection for the personal occupationally exposed. The particular objectives are: To evaluate the dose received in different parts of the body, for the personnel occupationally exposed (doctors, technicians and/or nurses) during studies with fluoroscopy. To compare the annual effective dose received by each OEP with the values of the limits settled down by the norms. To recommend protection measures in the event of being necessary. In the chapter 1 an introduction it is presented on the fluoroscopy, the types of studies that are carried out in interventionist fluoroscopy, as well as some characteristics of the equipment, and antecedents of studies carried out so much to patient as to the personnel. The chapter 2 contains the basic concepts of the interaction of the ionizing radiation with the matter, of the dosimetry and of the radiological protection. The characteristics and treatments of the dosemeters, the experimental techniques, devices and used calibration methods, as well as the studies with fluoroscopy and the regions of the body of the OEP for those that the measures of the dose were made are presented in the chapter 3. The chapter 4 contains the such experimental results as the values of the dose, for study in the different parts of the body, for the main doctors, auxiliary and anesthesiologist; the dose, for study, as function of the one time of duration of the study and of the patient's weight, as well as the annual effective dose to whole body, equivalent dose to crystalline, to hands, to feet and to skin, for each doctor and their comparison with the limits. The chapter 5 it contains the conclusions. Finally in the appendix the charts are included of the dose received by the principal doctor, the auxiliary doctor and the anesthesiologist during the carried out studies. (Author)

  8. Environmental radiological protection of Bariloche Atomic Center; Proteccion radiologica ambiental del Centro Atomico Bariloche

    Energy Technology Data Exchange (ETDEWEB)

    Andres, Pablo A.; Levanon, Izhar S., E-mail: andresp@cab.cnea.gov.ar, E-mail: levanon@cab.cnca.gov.ar [Comision Nacional de Energia Atomica (CNEA), San Carlos de Bariloche (Argentina). Centro Atomico Bariloche. Division Proteccion Radiologica

    2013-07-01

    This plan of monitoring radiological environmental routine fits on environmental policy of CNEA, satisfying national and international recommendations for licensed facilities. Sampling matrices are related to direct routes of exposure: air and water (river, lake, sediments, drinking water). Soil samples are also analyzed for having integrated matrices. They are considered as minimum three points of measurement: a white point (water or winds up), a point of maximum (water or winds down) and a point corresponding to the location of the individual representative or a point of public interest. Measurements in air estimate KERMA rate with thermoluminescent dosimeters, bi-monthly, and concentrations of particulate material and aerosols. For water samples (monthly), soil and sediments (quarterly), radionuclides that have download limits are analyzed, according to its importance in the dosages produced in the representative individual. In these cases artificial radionuclides using gamma spectrometry, beta total and Sr-90 by radiochemical techniques if the value of total screening (1 Bq/L) is exceeded. Foods are not included because no possible matrices were detected, either by their distance. by located not predominant wind direction. They are however still looking for milk producers that fulfills the minimum requirements.The data collected are compared with environmental baselines to set trends that might point to future significant changes in the environment during the life of the facilities. So far it was not observed significant differences with respect to baseline values.

  9. Radiological Protection Plan an ethic responsibility; Plano de protecao radiologica e responsabilidade etica

    Energy Technology Data Exchange (ETDEWEB)

    Huhn, Andrea, E-mail: andrea.huhn@ifsc.edu.br [Instituto Federal de Santa Catarina (IFSC), Florianopolis, SC (Brazil); Vargas, Mara Ambrosina de Oliveira, E-mail: mara@ccs.ufs.br [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil)

    2014-07-01

    The Radiological Protection Plan - PPR, quoted by the Regulatory Standard 32, requires to be maintained at the workplace and at the disposal of the worker's inspection the PPR, for it to be aware of their work environment and the damage that can be caused by misuse of ionizing radiation. Objective: to discuss the interface between PPR and ethical reflection. Method: this is a reflective study. Discussion and results: regulatory norm 32 points out that the worker who conducts activities in areas where there are sources of ionizing radiation should know the risks associated with their work. However, it is considered that the sectors of hospital radiology the multidisciplinary health team is exposed to ionizing radiation and has not always aware of the harm caused by it, so end up unprotected conduct their activities. Concomitantly, recent studies emphasize the radiological protection and concern for the dangers of radiation on humans, but rather refer to the legislation about the radiological protection. In this context an ethical reflection is necessary, seeking to combine work ethics liability to care in protecting themselves and the other with the institutional conditions for this protection becomes effective.

  10. Evolution of the radiological protection paradigms; Evolucao dos paradigmas de protecao radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Sordi, Gian Maria A.A. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Programa de Pos-Graduacao em Tecnologia Nuclear], E-mail: gmsordi@ipen.br

    2009-10-15

    We consider as initial radiological protection paradigms those in vigour after the release of the atomic energy for pacific usages in 1955. In that occasion, only one paradigm was introduced, presently named dose limitation system. After arguing about the basis that raised the paradigm, we introduced the guidance, that is, the measurements to be implemented to comply with the paradigm. In that occasion, they were two, i.e., the radiation dose monitoring and the workplace classification. Afterwards, the reasons that caused the radiological protection paradigms changes in force until 1995 are discussed. The initial paradigm was modified introducing the justification and the optimization principles, adding that the radiological protection should be economical and effective. The guidance also increased to four: personal monitoring, workplace classification, reference level and workers classification. Afterwards, we give the main justifications for the present paradigms that besides the formers were added the dose constraints, the potential exposure and the annual risk limits. Due to these modifications, the workers classifications were eliminated from the guidance, but the potential exposure and the search for the dose constraints were added. Eventually, we discuss the tendencies for the next future and the main changes introduced by the ICRP in the Publication 103, 2007. (author)

  11. Radiological findings of pulmonary Kaposi's sarcoma. Manifestaciones radiologicas del sarcoma de Kaposi pulmonar

    Energy Technology Data Exchange (ETDEWEB)

    Rosello, J.A.; Hernandez, S.; Arranz, M.; Jareo, J.; Ancoechea, J.

    1994-01-01

    Kaposi's sarcoma (KS) is the most common neoplasm in AIDS patients. The incidence of pulmonary involvement is approximately 20%. The radiological findings are reported in plain chest x-ray and computed tomography (CT) in 15 patients diagnosed as having pulmonary Kaposi's sarcoma, in whom concomitant pulmonary infection was ruled out. The most common radiological pattern was that of bilateral perihilar interstitial involvement (86%), while poorly defined multiple nodules seldom presented (13%). In 40% of cases, the pulmonary parenchymal lesion was accompanied by pleural effusion. This sign is useful in the differential diagnosis involving opportunistic P. carinii pneumonia, a very common process in these patients which rarely presents with pleural effusion. The chest CT finding that was most characteristic of pulmonary Kaposi's sarcoma was bilateral perihilar peribronchovascular enlargement. (Author)

  12. Radiological pulmonary manifestations of acquired immunodeficiency syndrome; Manifestacoes radiologicas pulmonares da sindrome da imunodeficiencia adquirida

    Energy Technology Data Exchange (ETDEWEB)

    Marchiori, Edson; Melo, Alessandro Severo Alves de; Ossa, Alfonso Jaramillo [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia

    1999-06-01

    In this article are reviewed the principal radiologic manifestations of inflammatory and tumoral diseases the compromise the lungs of patients with acquired immunodeficiency syndrome. In the group of inflammatory diseases the radiologic aspects of pneumocystosis, cytomegalovirus disease, cryptococcosis, tuberculosis and bacterial pneumonias are emphasized. In the neoplasic diseases' group the aspects of lymphoma and Kaposi's sarcoma are specially presented. (author)

  13. Medical intervention in radiological emergencies, formation and training; Intervencion medica en emergencias radiologicas, formacion y adiestramiento

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas H, J. [CPHR, Calle 20 No. 4113, e/41 y 47 Playa, CP 11300, La Habana (Cuba)]. e-mail: cardenas@cphr.edu.cu

    2006-07-01

    The work exposes the national experience in the development of training programs in medical aspects of the radiological emergencies. Implemented after valuing the existent situation, identified the necessities and the reach of the training, additionally it was elaborated the content of the training program whose purpose is guided to the invigoration of the medical answer capacity in radiological emergencies The content of the modular program it approaches theoretical- practical aspects on preparation and medical answer in radiological emergencies. The program includes an exercise that simulates a radiological accident, to evaluate during the same one, the answer capacity before this situation. The training concludes with the design of a strategy for the preparation and answer in radiological emergencies in correspondence with the potential accidental scenarios that the participants can face. (Author)

  14. Radiological protection in nuclear power plants; La proteccion radiologica en las centrales nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Zorrilla R, S. [CFE. Central Laguna Verde, Km. 42.5 Carretera Cardel-Nautla, Veracruz (Mexico)

    2008-12-15

    This presentation sharing experiences which correspond to the nuclear power plant of Laguna Verde. This nuclear power plant is located at level 2 of four possible, in the classification performance of the World Association of Nuclear Operators (WANO), which means the mexican nuclear power plant is classified in terms of its performance indicators and above the average achieved by their counterparts americans and canadians. In the national context, the nuclear power plant of Laguna Verde has also been honored with several awards such as the National Quality Award, the Clean Industry Certificate, the distinction of Environmental Excellence and others of similar importance. For the standards of WANO, the basic idea is that there are shortcomings in one of nuclear power plant concern to all partners. The indicators used for the classification will always go beyond more compliance with regulations, which are assumed, and rather assume come or a path to excellence. Among the most important indicators are: the collective dose, the percentage of areas declared as contaminated, the number, type and tendency of contamination personal cases, the number of dosimetry alarms, the number of unplanned exposures, loss control of high radiation areas and the release of contaminated material outside the restricted areas. Furthermore, as already indicated, nuclear power plants are of special care situations, such as, carrying out work in areas with radiation fields of more than 15 mSv h{sup -1}, the movement of spent fuel in the reload floor. The consideration of the minimum total effective dose equivalent as a criterion for prescribing tools that reduce exposures, but may increase the external cases of contaminated casualties, the experience in portals such as workers subject to radiology, where exposure in industrial radiography, and so on. Special mention deserve the conditions generated during fuel reload stops, which causes a massive personnel movement, working simultaneously on several fronts, the number of dosimetry transactions, increases up to 30 times the normal operation, and so on. For these reasons during the reloads, the electronic dosimetry system and the monitoring system output contamination staff becomes critical systems whose functioning must be ensured to avoid becoming a bottleneck. Reloads must also be planned for a perfect manning of critical supplies such as clothing and protection accessories against contamination. (Author)

  15. e-Learning applications for radiological protection training; Aplicaciones de la teleformacion en la proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, F.; Gomez-Arguello, B.; Callejo, J. L.

    2003-07-01

    The unattended training, through e-learning platforms, offers advantages in comparison with the traditional attended training, such as, freedom to study when, where and how the trance desires, the student is learning customization, a continuous self evaluation of the learning process and the rhythm of study, etc. To explore the possibilities of the radiological protection training in a WEB site, a first application for External Workers has been developed. The high number of students, their geographical dispersion and their different level of knowledge and experience arise attended training limitations in this area. In this article, the WEB course Basic Radiological Protection is presented and the results, preliminarily conclusions and lesson learnt are analysed. (Author) 7 refs.

  16. Constitutional osteochondrodysplasias identifiable a birth. A short review on the state of the art in radiodiagnostic in the late 20. century; Le osteocondrodisplasie costituzionali riconoscibili alla nascita. Una breve rassegna sullo studio dell'arte radiodiagnostica sul finire del 20. secolo

    Energy Technology Data Exchange (ETDEWEB)

    Gugliantini, P.; Maragliano, G.; Piscione, M.; Licata, G. [Azienza Ospedaliera San Giovanni - Addolorata, Rome (Italy)

    1999-03-01

    The value of a systematic radiologic analysis in constitutional osteochondrodysplasias remains underestimated by both neonatologists and radiologists. The authors report the clinical experience of the Department of Neonatology and Neonatal Intensive Cure Unit of St. John Hospital in Rome with constitutional osteochondrodysplasias identifiable at birth. The authors justify the relatively high incidence of constitutional osteochondrodysplasias in this study (66% versus an average incidence of 0,076% reported in the world population) on the basis of: a) an increasing number of high-risk newborns in the intensive cure; b) an improvement in our clinical and radiologic diagnostic skill. They conclude that the state of the art of diagnostic of constitutional osteochondrodysplasiasin still based on the first plain X-ray examination performed at birth because of cardiorespiratory and/or abdominal diseases in the newborn. [Italian] L'importanza dell'analisi radiologica sistematica delle osteocondrodisplasie costituzionali e' tutt'ora sottostimata sia dai neonatologi che dai radiologi. Pertanto riferiamo l'esperianza clinico-radiologica di osteocondrodisplasie costituzionali identificabili alla nascita nel Dipartimento di Neonatologia e Terapia Intensiva Neonatale dell'Ospedale San Giovanni di Roma. L'articolo conclude giustificando la relativamente alta incidenza di ostecondrodisplasie costituzionali della casistica in esame (0,66% contro l'incidenza media dei 0,076% riferita alla popolazione mondiale) sulla base di: a) crescente numero di neonati con alto rischio ricoverati nella unita' di terapia intensiva; b) miglioramento delle capacita' diagnostiche, sia cliniche che radiologiche.

  17. Immunological Prevention of Spontaneous Mammary Carcinoma in Transgenic Mice

    Science.gov (United States)

    2001-08-01

    developed more slowly by transgenic FVB Anatomia Patologica, Ospedale S.S. Annunziata, Via Valignani, 66100 female mice carrying the wild-type proto...coopted (Pezzella et al., 1997). Anatomia Patologica. Ospedale SS. Annunziata, Via Valignani, 66100 Chieti, Italy. Fax: 39 0871 330471. E-mail: musiani...lo Studio e la Cura dei Tumori, Milan, Italy; and Reprints: Piero Musiani, G. d’ Annunzio University of Chieti, Anatomia Department of Experimental

  18. Workshop on radiation protection of patient. Workshop on radiation protection of worker in nuclear medicine and biomedicine; Taller sobre proteccion radiologica del paciente. Taller sobre proteccion radiologica del trabajador en medicina nuclear y biomedicina

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    In these workshops, information on the following subjects was presented: biological and prenatal effects of ionizing radiation, excretion of radiopharmaceuticals in human breast milk, fetal doses assessment, final disposal of radioactive waste in medical applications, regulatory functions for installations in nuclear medicine, workers doses in nuclear medicine and biomedicine, radioprotection of their nuclear installations, programs of quality assurance, etc.

  19. Main radiation protection actions for medical personnel as primary responders front of an event with radiological dispersive device; Principais acoes de protecao radiologica para equipe medica como primeiros respondedores frente a um evento com dispositivo de dispersao radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Duque, Hildanielle Ramos

    2015-07-01

    After the terrorist attack in New York, USA, in 2001, there was a worldwide concern about possible attacks using radioactive material in conventional detonators, called as Radiological Dispersal Device (RDD) or 'dirty bomb'. Several studies have been and are being made to form a global knowledge about this type of event. As until now, fortunately, there has not been an event with RDD, the Goiania Radiological Accident in Brazil, 1987, is used as a reference for decision-making. Several teams with technical experts should act in an event with RDD, but the medical staffs who respond quickly to the event must be properly protected from the harmful effects of radiation. Based on the radiological protection experts performance during the Goiania accident and the knowledge from lessons learned of many radiological accidents worldwide, this work presents an adaptation of the radiation protection actions for an event with RDD that helps a medical team as primary responders. The following aspects are presented: the problem of radioactive contamination from the explosion of the device in underground environment, the actions of the first responders and evaluation of health radiation effects. This work was based on specialized articles and papers about radiological accidents and RDD; as well as personal communication and academic information of the Institute of Radiation Protection and Dosimetry. The radiation protection actions, adapted to a terrorist attack event with RDD, have as a scenario a subway station in the capital. The main results are: the use of the basic radiation protection principle of time because there is no condition to take care of a patient keeping distance or using a shielding; the use of full appropriate protection cloths for contaminating materials ensuring the physical safety of professionals, and the medical team monitoring at the end of a medical procedure, checking for surface contamination. The main conclusion is that all medical actions as primary responders must be followed up by radiation protection specialists. (author)

  20. Radiation nursery and occupational exposure: state-of-art; Enfermagem radiologica e os riscos ocupacionais: estado da arte

    Energy Technology Data Exchange (ETDEWEB)

    Melo, J.A.C.; Huhn, A.; Viana, E.; Rosa, G., E-mail: julianac@ifsc.edu.br [Instituto Federal de Educaco, Ciencia e Tecnologia de Santa Catarina (IFSC), Florianopolis (Brazil); Luz, K.R. [Universidade Federal de Santa Catarina (UFSC), Florianopolis (Brazil); Derech, R. [Prefeitura Municipal de Florianopolis, SC (Brazil)

    2015-07-01

    Documentary research with the aim to reflect on the state of the art in radiological nursing, on the nursing work and occupational hazards they are exposed, from articles produced in Brazil. The survey was conducted in the BVS, the study consisted of seven articles published from 2002 to 2012. Regarding the main variables studied in the articles, issues emerged related to working conditions and biosafety, performance of nurses, legislation, continuing education and difficulties and needs of nursing staff . It was noticed that is recent the interest in the field, but the work of nurses in radiological technologies must be grounded in current scientific knowledge and with proper technique, to the achievement of the desired clinical outcome and to promote their safety, the team and also the patient. (author)

  1. Report of radiological safety for a micro PET; Informe de seguridad radiologica para un microPET

    Energy Technology Data Exchange (ETDEWEB)

    Gallegos M, R.; Ruiz T, C. G.; Martinez D, A.; Rodriguez V, M., E-mail: romeo@fisica.unam.m [UNAM, Instituto de Fisica, Circuito de la Investigacion Cientifica, Ciudad Universitaria, 04510 Mexico D. F. (Mexico)

    2010-09-15

    Considering one of the guides emitted by the National Commission of Nuclear Security and Safeguards, was realized the report of radiological safety for a micro tomography by positrons emission that is part of Bimodal System of Images developed in their entirety for personnel of the Physics Institute of UNAM. With this system is sought to obtain tomography images of small animals using non destructive methods, such as computerized micro tomography and micro tomography by positrons emission. In this work each one of the report points is enumerated and only it is described, to big features on that consist, due to the great extension of each one of them. The report has two parts; the first is denominated -Of the installation and the Organization- and is given to know the interior and external characteristics of the installation, besides how and under which authority the activities will be executed inside the laboratory. The second part is called -of the Radiological Protection- and has for objective to describe the radiation sources that will be used, as well as the measures of radiological protection foreseen inside the laboratory. The most important part in the report consists on the description of the three radionuclides to use: {sup 18}F, {sup 11}C and {sup 13}N, as well as the methods for the shielding calculation and for the estimate of the dose equivalent during the normal operation of the equipment. These methods were applied three times, because the calculation was made for each radionuclide. The results of these calculations show that: 1) it not is necessary to have a structural shielding, due to the activity sources very reduced, and 2) the dose limit per year (according to the ICRP-60) it will not be surpassed neither in the case of the occupationally exposed personnel, neither on the public in general. (Author

  2. Surveillance and radiological protection in the Hot Cell laboratory; Vigilancia y proteccion radiologica en el Laboratorio de Celdas Calientes

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, J.M.; Torre, J. De la; Garcia C, M.A. [ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2004-07-01

    The Hot Cells Laboratory (LCC) located in the National Institute of Nuclear Research are an installation that was designed for the management at distance of 10,000 Curies of Co-60 or other radioactive materials with different values in activity. The management of such materials in the installation, implies to analyze and to determine the doses that the POE will receive as well as the implementation of protection measures and appropriate radiological safety so that is completed the specified by the ALARA concept. In this work it is carried out an evaluation of the doses to receive for the POE when managing radionuclides with maximum activities that can be allowed in function of the current conditions of the cells and an evaluation of results is made with the program of surveillance and radiological protection implemented for the development of the works that carried out in the installation. (Author)

  3. Training activities in radiation protection and nuclear technology CIEMAT; Acciones formativas en proteccion radiologica y tecnologia nuclear de CIEMAT

    Energy Technology Data Exchange (ETDEWEB)

    Falcon Cabrera, S.; Fernandez Sanchez, J.; Marco Arboli, M.

    2013-07-01

    This work presents the different training activities that are being developed annually according to the demand detected in society, in business or in the national and international organizations involved, as well as the various forms of provision of these services by CIEMAT. (Author)

  4. Radiological quality in drinking water from Granada city; Calidad radiologica del agua potable de la ciudad de Granada

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Penalver, J. J.; Gonzalez Gomez, C.; Ferro Garcia, M. A.; Prados Joya, G.

    2007-07-01

    The purpose of this study is to present data on gross alpha and beta activities in the drinking water from Granada city, during six years, 2000 to 2005. The samples were measured using a gas-flow proportional counter Bert hold LB 770-2/5. The results show that the gross alpha and gross beta cavity is lower than the maximum contaminant level based on the World Health Organisation, who which indicates 0.1 Bq.1-1 and 1.0 Bq.l''-1 as maximum contaminant level of gross alpha and gross beta radioactivity in potable water, respectively. Concentration ranging from 4.1.10''-3 to 3.9.10''2 Bq.l''-1 and from 4.9.10''-3 to 5.6.10''-2 Bq.l''-1 were observed from the gross alpha and beta activities, respectively. An average annual effective dose equivalent of 2.909 {mu}Sv-yr''-1 was obtained together with a range of 0.186 to 0.326 {mu}Sv.mo''-1. (Author) 10 refs.

  5. Radiation protection instrumentation at the Andalusian health service; Instrumentalizacion de la proteccion radiologica en el servicio Andaluz de salud

    Energy Technology Data Exchange (ETDEWEB)

    Herrador Cordoba, M [Servicio de Radiofisica, Hospital Universitario Virgen del Rocio, Sevilla (Spain); Garcia Rotllan, J [Servicios Centrales del Servicio Andaluz de Salud, Sevilla (Spain)

    1997-11-01

    In Andalusia the contributions of radiological risks in the nuclear industry and of natural radiation are small and the same holds for medical applications of individuals and research. The performance models in radiation protection is monitored by the Andalusian Health Service through the public health institutions. This short communication describes the model and results obtained. 3 refs.

  6. Ionizing radiation, nuclear energy and radiation protection for school; Radiacao ionizante, energia nuclear e protecao radiologica para a escola

    Energy Technology Data Exchange (ETDEWEB)

    Lucena, E.A.; Reis, R.G.; Pinho, A.S.; Alves, A.S.; Rio, M.A.P.; Reis, A.A., E-mail: arlene@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Silva, J.W.S. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Paula, G.A. de; Goncalves Junior, M.A. [Escola Sesc de Ensino Medio, Rio de Janeiro, RJ (Brazil)

    2017-04-01

    Since the discovery of X-rays in 1895, ionizing radiation has been applied in many sectors of society, such as medicine, industry, safety, construction, engineering and research. However, population is unaware of both the applications of ionizing radiation and their risks and benefits. It can be seen that most people associate the terms 'radiation' and 'nuclear energy' with the atomic bomb or cancer, most likely because of warlike applications and the stealthy way radioactivity had been treated in the past. Thus, it is necessary to clarify the population about the main aspects related to the applications, risks and associated benefits. These knowledge can be disseminated in schools. Brazilian legislation for basic education provides for topics such as nuclear energy and radioactivity to high school students. However, some factors hamper such an educational practice, namely, few hours of class, textbooks do not address the subject, previous concepts obtained in the media, difficulty in dealing with the subject in the classroom, phobia, etc. One solution would be the approximation between schools and institutions that employ technologies involving radioactivity, which would allow students to know the practices, associated radiological protection, as well as the risks and benefits to society. Currently, with the increasing application of ionizing radiation, especially in medicine, it is necessary to demystify the use of radioactivity. (author)

  7. Project SIMORAC: a wireless system for radiation monitoring in emergencies; Proyecto SIMORAC: Un sistema inalambrico para monitorizacion radiologica en emergencias

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, D.; Serrano, J. L.; Cabrera, E.; Barbaran, J.; Llopis, L.; Diaz, M.

    2013-07-01

    The SIMORAC project includes a new system for Radiological monitoring using wireless sensor networks (RSIs), without infrastructure planning in emergency situations for a rapidly deployable by air or land, with the aim of providing a tool emergency teams capable of offering a real time x-ray map within the radius of action of an accident. Communication of quality at a great distance, resistance to weather, long autonomy and possibility of aerial deployment are some of the features of SIMORAC.

  8. Proceedings of the Fourth Session of Radioprotection of the patient; Actas de la 4. Jornada de Proteccion Radiologica al Paciente

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    The Radiology Argentine Society and the Radioprotection Argentine Society have organized the 4. Session of the Protection to the Patient, in order to inform to the technical and scientific community about the scopes of the radioprotection to the patient. The principal treated topics were the following: effects of the radiation in radiodiagnostic; radioprotection of the fetus and the pregnancy woman; radioprotection in dental radiology; radiological protection in TAC; radiation doses in radiodiagnostic; treatment of radiation injuries; fatal accidents in radiotherapy. [Spanish] La Sociedad Argentina de Radiologia, y la Sociedad Argentina de Radioproteccion, han organizado la 4ta. Jornada de Proteccion al Paciente, con el objeto de informar a la comunidad cientifico y tecnica sobre los alcances de la radioproteccion al paciente. Los principales temas tratados fueron los siguientes: efectos de la radiacion en radiodiagnostico; radioproteccion del feto y la mujer gestante; radioproteccion en radiologia odontologica; proteccion radioogica en TAC; dosis de radiacion en radiodiagnostico; tratamiento de lesiones por radiacion; accidentes fatales en radioterapia.

  9. Radiological protection in quality control in dental radiology; Proteccion radiologica y control de calidad en radiologia dentaria

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Salaberry, Mirtha [Direccion National de Tecnologia Nuclear, Montevideo (Uruguay)

    1994-06-01

    Many regulations were given in this article about ionizing radiation biological effects in the dental area. With the purpose to find a good dentistry professional reception it presents procedures for the use of X-ray dental equipment.

  10. Regulation of radiological protection for patients under radiodiagnosis; Proposta de regulamentacao da protecao radiologica do paciente em radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Yacovenco, Alejandro [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia; Ferreira, R.S. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil). Superintendencia de Licenciamento e Controle; Souza, A.C.A. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Dept. de Fisico-Quimica

    1997-12-31

    Face to the increasing exposition of the population to ionizing radiations and the needs to fulfill user`s rights, political and scientific efforts have been made in order to improve image quality and reduce risks to patients. A proposal to create a National Reference Laboratory to survey, supervise and evaluate the implementation of norms which require the control of physical parameters of the radiological equipment is presented. Aspects related to the profile of the Medical Physicist are also discussed. (author) 5 refs.; e-mail: yacovenco at serv.peb.ufrj.br; rubemar at dpx.cnen.gov. br; cecilia at iq.ufrj.br

  11. IMRT and radiation protection in the prostate cancer therapy; IMRT e a protecao radiologica no tratamento do cancer de prostata

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Helena C.; Silva, Andre R.M.; Oliveira, Claudia F.M., E-mail: andrerichard88@bol.com.br [Instituto Federal de Educacao, Ciencia e Tecnologia de Pernambuco (IFPE), Recife, PE (Brazil)

    2015-07-01

    This study aims to specify the technological advances that IMRT presents relative to other traditional radiotherapy, particularly to conformal radiotherapy three dimensional (3D-TCR) and benefits compared to the side effects caused by from treatment of radiotherapy.

  12. The musculoskeletal radiologic findings associated with chronic renal insufficiency; Manifestaciones radiologicas musculoesqueleticas de la insuficiencia renal cronica

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz, P J; Gomez, I; Hernandez, L; Relanzon, S; Hurtado, M [Hospital General Universitario Gregorio Maranon, Madrid (Spain)

    1997-10-01

    The numerous musculoskeletal changes associated with chronic renal insufficiency (CRI) are detected with increasing frequency since hemodialysis and kidney transplantation have prolonged the survival of these patients. These signs have been divided into two large groups. The first includes secondary hyperparathyroidism (bone resorption, periostitis and brown tumors), osteoporosis, osteosclerosis, osteomalacia and vascular and soft tissue calcification, all of which are grouped under the term renal osteodystrophy. the second group is composed of miscellaneous disorders including aluminum poisoning, amyloid and crystal deposition, destructive spondyloarthropathy, tendon rupture, infection and avascular necrosis. These changes are less common and occur especially in patients under prolonged hemodialysis or kidney transplant recipients. The detection of musculoskeletal involvement in CRI patients has a considerable impact on their clinical management. The present article reviews the radiological signs of these changes, including representative images that will aid in their recognition. (Author) 33 refs.

  13. The radiological protection in the practice of industrial X-rays; La proteccion radiologica en la practica de radiografia industrial

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez C, I.; Carrasco C, R., E-mail: ijcastro@cnsns.gob.m [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2010-09-15

    The kindness of this technique of non destructive assays is very appreciative when the protection standards and radiological protection are completed faithfully, this work show in a succinct way the development through the years where have improved the equipment s, the procedures, the training and the regulation. This development has allowed reduce the dose to the occupational exposed personnel, to the public, but mainly the accidents incidence with loss of fingers, hands, legs and worker lives, children and the people in general. (Author)

  14. The radiological protection in the nuclear medicine practice; La proteccion radiologica en la practica de medicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Maldonado M, H., E-mail: hmaldonado@cnsns.gob.m [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2010-09-15

    The nuclear medicine practice dates of the 1950 years, in this work the achievements reached as regards radiological protection are shown, although even lack a lot to make, the doses for the occupationally exposed personnel have decreased with lapsing of the years, thanks to the perception of the nuclear physicians to improve the administration techniques of the radioactive material, the decrease of administered activity and the unit doses use among the most remarkable advances. The changes in the equipment s technology to quantify the activity to administer, detection systems and image formation have demanded the development of the new professionals of the nuclear medicine that allows give protection to the patient. This improvement needs to consolidate with the appropriate normative development, the involved personnel qualification and the methods and procedures actualization to improve the protection of the occupationally exposed personnel, the public, the environment and the patient. (Author)

  15. Use of social networks to improve radiation protection; Uso de las redes sociales para mejorar la proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Medina Gironzini, E.

    2013-07-01

    The development of information and communication technologies has improved relations between the specialists in radiation protection worldwide. Takes advantage of these media to exchange experiences on issues of common interest and technical concerns are resolved in very short times. (Author)

  16. Radiologically detectable musculoskeletal involvement in systemic lupus erythematosus; Afectacion musculoesquelitca con expresion radiologica en el lupus eritematoso sistemico

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, M. M.; Manjon, P.; Diaz de Bustamante, T.; Galindo, M.; Buj, M. J.; Cabezudo, J. [Hospital Doce de Octubre de Madrid (Spain)

    2000-07-01

    We show a wide spectrum of musculoskeletal involvement in systemic lupus erythematosus (SLE) that can be detected by radiological examination. We determined the indications of different imaging techniques in the diagnosis and follow-up of this disease. We reviewed the clinical and radiological histories of 37 patients diagnosed as having SLE on the basis of serological and musculoskeletal criteria. We assessed the personal data of each patient, the association of the disease with autoimmune processes, serology, treatment and radiological findings using plain X ray, ultrasound, computed tomography (CT) and magnetic resonance (MR). Of the 37 cases reviewed, only ten presented changes in one or more of the imaging studies performed. the most common radiological finding was symmetric poly arthritis located at different sites. Other signs included avascular necrosis (late and early), inflammation and tendon and/or ligament rupture, nonerosive deforming arthropathies , soft tissue calcifications and arthritis (staphylococcal and tuberculous). A direct correlation was established between the anticardiolipin antibody titer, steroid doses and avascular necrosis. In SLE, radiologically detectable osteoarticular lesions are uncommon. Symmetric polyarthritis is the earliest lesion and that occurring most frequently. Other signs do not appear as often, with the exception of osteonecrosis, which usually occurs late. It developed early and was unusually aggressive in two youths with elevated anticardiolipin antibody titers and substantial systemic involvement in our series. The contributions of ultrasound and MR in the assessment of musculoskeletal involvement in SLE are especially relevant in the study of inflammations and tendon rupture and in the management of avascular necrosis, respectively. (Author) 17 refs.

  17. Radiological protection procedures for industrial applications of computed radiography; Procedimentos de protecao radiologica em aplicacoes industriais da radiografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Aquino, Josilto Oliveira de

    2009-03-15

    Due to its very particular characteristics, industrial radiography is responsible for roughly half of the relevant accidents in nuclear industry, in developed as well as in developing countries, according to the International Atomic Energy Agency (IAEA). Thus, safety and radiological protection in industrial gamma radiography have been receiving especial treatment by regulatory authorities of most Member States. The main objective of the present work was to evaluate, from the radioprotection point of view, the main advantages of computed radiography (CR) for filmless industrial radiography. In order to accomplish this, both techniques, i.e. conventional and filmless computed radiography were evaluated and compared through practical studies. After the studies performed at the present work it was concluded that computed radiography significantly reduces the inherent doses, reflecting in smaller restricted areas and costs, with consequent improvement in radiological protection and safety. (author)

  18. Radiological security of portable equipment used in the industry; Seguridad radiologica de equipos portatiles utilizados en la industria

    Energy Technology Data Exchange (ETDEWEB)

    Cateriano, M.A. [Autoridad Regulatoria Nuclear, Av. Del Libertdor 8250, (C1429BNP), Ciudad Autonoma de Buenos Aires (Argentina)]. e-mail: mcateria@sede.arn.gov.ar

    2006-07-01

    The industrial meters with encapsulated sources are used intensely in the present time due to the economic benefits that generate. Their use in all the one world has been reflected in an improvement of the quality of the analyzed product and of one optimization of the production process, allowing to carry out these measurements and controls without interrupting the process and in non destructive form generating an energy saving in turn and of materials. Although these industrial meters are intrinsically safe for design in the portable meters their safety also is strongly governed in the strict pursuit of procedures and in the adequate personnel's training that operate these equipment. In the Argentine Republic in 2005 the Nuclear Regulatory Authority (RNA) had registered a quantity of 160 portable equipment. In the period 1995-2003, 2 incidents took place with these equipment one of them used to measure soils humidity of Troxler trademark containing a source of Am-241(Be) of 370 MBq and the remaining one also of Troxler trademark used to measure density and humidity of soils containing 2 sources of Cs-137 of 296 MBq and Am-241(Be) of 1.48 GBq respectively. The incidents were developed without relevant radiological implications had taken place. In this work those mentioned incidents are analyzed in order to determining the causes that originated the same ones, for this way to be able to elaborate recommendations with the purpose of to correct errors and to diminish the recurrence probability improving the safety in the use of these equipment. From the analyses of these incidents result that should put on more emphasis in the personnel training and the invigoration of the safety culture in the use of the industrial meters. Also a present panorama of the inventory of equipment, sources and users that possess these portable meters in the Argentine Republic is also presented. (Author)

  19. Digital processing methodology applied to exploring of radiological images; Metodologia de processamento digital aplicada a exploracao de imagens radiologicas

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Cristiane de Queiroz

    2004-07-01

    In this work, digital image processing is applied as a automatic computational method, aimed for exploring of radiological images. It was developed an automatic routine, from the segmentation and post-processing techniques to the radiology images acquired from an arrangement, consisting of a X-ray tube, target and filter of molybdenum, of 0.4 mm and 0.03 mm, respectively, and CCD detector. The efficiency of the methodology developed is showed in this work, through a case study, where internal injuries in mangoes are automatically detected and monitored. This methodology is a possible tool to be introduced in the post-harvest process in packing houses. A dichotomic test was applied to evaluate a efficiency of the method. The results show a success of 87.7% to correct diagnosis and 12.3% to failures to correct diagnosis with a sensibility of 93% and specificity of 80%. (author)

  20. Phyllodes tumor: clinical, radiological and pathological correlation in 50 cases; Tumor filodes: correlacion clinica, radiologica y anatomopatologica en 50 casos

    Energy Technology Data Exchange (ETDEWEB)

    Higueras, A.; Alvarez, M.; Jimenez, A.; Garcia Revillo, J.; Cano, A. [Hospital Universitario Reina Sofia. Cordoba (Spain)

    2000-07-01

    To review the radiological features of the phyllodes tumor, correlating them with the clinical presentation, histological type and response to treatment. Fifty phyllodes tumors in 29 patients aged 16 to 59 years (mean: 41 years) were analyzed retrospectively. The series included 12 cases of recurrence, 1 of bilateral tumor and 6 of multiple tumor. Forty-five lesions were studied by mammography and 36 by ultrasound. Clinically guided fine-needle aspiration cytology was performed in 8 cases. The pathological diagnosis was obtained by means of surgical biopsy in every case (31 benign and 19 malignant). Twenty-four patients underwent postoperative clinical and radiological follow-up for a mean period of 32 months. Mammography revealed the presence of a nodule or mass in 42 cases, asymmetrical density in two and a generalized increase in density in one: Multifocal lesions were detected in six cases. The size varied widely, with masses measuring >5 cm showing a greater probability of malignancy (p<0.01). Calcifications were observed in 13% of the cases. Ultrasound revealed the presence of heterogeneous, hypoechoic nodules, with cystic areas in five tumors, all of which were malignant (p<0.01). Local recurrence was detected in 31% of the cases and bone metastases in one. The phyllodes tumor is an uncommon fibroepithelial tumor that has a potential for recurrence and distant metastasis. Mammographic and ultrasound features are similar to those of the fibroadenoma, a lesion with which it is occasionally associated. Multiple lesions are not infrequent and it can present with calcifications. The presence of cystic areas and a tumor size of >5 cm are the only radiological findings that are statistically associated with malignancy. The recurrence rate is greater in malignant tumors than in benign lesions, especially in patients treated by tumor resection. (Author) 28 refs.

  1. Training in fundamentals of radiological coverage in Laguna Verde NPP; Entrenamiento de fundamentos de coberturas radiologicas en la CLV

    Energy Technology Data Exchange (ETDEWEB)

    Lara H, M. A., E-mail: marcolarah@gmail.com [Comision Federal de Electricidad, Central Nucleoelectrica Laguna Verde, Carretera Cardel-Nautla Km. 42.5, Alto Lucero, Veracruz (Mexico)

    2014-10-15

    In 2010, the Institute of Nuclear Power Operations (INPO) celebrates the Knowledge Transfer and Retention Workshop, an event where nuclear regulators and operators presented the strategies that various NPP to worldwide were implemented to mitigate the consequences of this generational change and take advantage of it, the trend in the presented works was the same: the generational change occurs in a faster way that the transfer of knowledge, the future was already here and many NPP had not been adequately prepared to train its nuclear technicians and engineers in the tasks demanded by the industry of them, so in addition to preparing these workers to forced marches was necessary to establish strategies to retain at more experienced staff in the industry. The Laguna Verde NPP has not been exempt to this process; the preparation of personnel squares to replace those that reaching retirement age in the Comision Federal de Electricidad (CFE) has become extensive in the last five years, sometimes leading to have personnel covering functions without an alternate to the next lower position, the cause? Not enough staff. In the specific case of radiation protection (Rp) the time required for obtaining the status of Rp technician according to the ANSI/ANS 3.1 standard is 2 years, one of the tasks that most occupies part of these two years is training in radiological coverage, this training requires a mix of knowledge and experience, recently one of the concepts used for training in Rp is the evaluation and management of the radiological risk, topic that is considered in this technical work. (Author)

  2. Radiological safety around a Linac of 18 MV; Seguridad radiologica alrededor de un LINAC de 18 MV

    Energy Technology Data Exchange (ETDEWEB)

    Ceron R, P.; Rivera M, T. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Calz. Legaria No. 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico); Paredes G, L. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico); Azorin N, J. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, San Rafael Atlixco No. 186, Col. Vicentina, 09340 Mexico D. F. (Mexico); Sanchez, A. [IPN, Escuela Superior de Fisica y Matematicas, Av. IPN s/n, Edif. 9, Col. San Pedro Zacatenco, 07738 Mexico D. F. (Mexico); Vega C, H. R., E-mail: victceronr@hotmail.com [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 09868 Zacatecas (Mexico)

    2014-10-15

    There are now several neutron detection systems, such as proportional counters based on BF{sub 3}, He{sub 3} and Bonner sphere spectrometers. However, the cost and complexity of the implementation of such systems makes them inaccessible for dosimetry purposes in radiotherapy rooms (Rt) and other facilities with this type of radiation fields. For these reasons the use of a neutron detection system is proposed composed by a paraffin moderator media forming an array 4π (spheres) and several pairs of thermoluminescent dosimeters TLD 600/TLD 700 inside, in order to make useful measurements for radiation protection around high-energy lineal accelerators (Linacs). In the first part of this work the system response when irradiated with a source of Pu Be and their corresponding calibration factor is displayed. In the second part are presented the ambient dose equivalent (H(10)) due to neutrons at various points of a living of Rt with a Linac of 18 MV, which are in the order mSv/Gy by X-ray treatment. The measurements made are similar to those taken in the memories of the accelerator and in previous work for this type of facility. (Author)

  3. Radiological respiratory protection in Angra-1 Nuclear Power Plant; Protecao respiratoria radiologica na Usina Nuclear de Angra

    Energy Technology Data Exchange (ETDEWEB)

    Amaral, Marcos A. do [Furnas Centrais Eletricas S.A., Angra dos Reis, RJ (Brazil). Central Nuclear de Angra I. Div. de Protecao Radiologica e Ambiental

    1996-07-01

    The present paper has the purpose to describe the actual situation of the Radiological respiratory Protection in Angra I Nuclear Power Plant, the difficulties found and the goals to achieve, in order of the radiological protection excellence. (author)

  4. Protective equipment of radiological protection and the worker wear; Equipamento de protecao radiologica e o desgaste do trabalhador

    Energy Technology Data Exchange (ETDEWEB)

    Cassia, Flor Rita de; Huhn, Andrea, E-mail: flor@ifsc.edu.br [Instituto Federal de Educacao, Ciencia e Tecnologia de Santa Catarina (IFSC), Florianopolis, SC (Brazil); Lima, Gelbcke Francine, E-mail: fgelbcke@ccs.ufsc.br [Universidade Federal de Santa Catarina (PEN/UFSC), Florianopolis, SC (Brazil). Programa de Pos-Graduacao em Enfermagem

    2013-11-01

    This qualitative research with workers of seven hemodynamic service of Santa Catarina, Brazil aimed to analyze the use of radiological protection equipment (RPE), as well as wear to the health of workers who use these causes. The study was conducted between March 2010 and November 2010, totaling approximately 30 hours of observations. Results showed resistance to the use of RPE and also showed wear to workers' health, mainly due to the weight and discomfort they cause, as may weigh 7-9 pounds, depending on the model used. Evidenced also the absence of workers due herniated disc, back pain, and other musculo skeletal problems. These complaints, in addition to being related to the use of these protective gear also related with the time that workers remain standing for long periods on certain procedures, such as angioplasty. Given these results, the research recommended the use of these devices with materials, that are already being produced, making lighter aprons, thus avoiding fatigue and back pain and also provide greater comfort by reducing workers' resistance to its use and its adverse consequences.

  5. Independent auto evaluation of an operative radiological protection program; Autoevaluacion independiente de un programa de proteccion radiologica operativa

    Energy Technology Data Exchange (ETDEWEB)

    Medrano L, M.A.; Rodriguez C, C.C.; Linares R, D.; Zarate M, N.; Zempoalteca B, R. [Gerencia Subsede Sureste Instituto Nacional de Investigaciones Nucleares, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: maam@nuclear.inin.mx

    2006-07-01

    The program of operative radiological protection of a nuclear power plant consists of multiple procedures and associate tasks that have as purpose the radiological protection of the workers of the power station. It is for this reason that the constant evaluation of the one it programs it is an important tool in the identification of their weaknesses (and strengths), so they can be assisted appropriately. In this work the main elements of the program of independent auto evaluation of the program of operative radiological protection of the Laguna Verde Central that has been developed and implemented by the National Institute of Nuclear Research are described. (Author)

  6. Radiation protection in occupational exposure to microwave electrotherapy units; Proteccion radiologica en exposicion ocupacional a microondas en unidades de electroterapia

    Energy Technology Data Exchange (ETDEWEB)

    Guardia, V.; Ferrer, S.; Alonso, O.; Almonacid, M.

    2012-07-01

    During the last years, electromagnetic emitters are more and more commonly used for therapeutic treatments in electrotherapy centers. This extended use has caused worries workers, who believe that microwave radiation radiation might have effects similar to those induced by radioactivity, even if the only effects recognised by international regulatory bodies concerning microwave exposure of humans are those of thermal origin. The present study aims to answer the existing concerns about electromagnetic exposure in electrotherapy facilities. After monitoring environmental values in an electrotherapy facility, we conclude that actions must be undertaken in order to reduce the exposure levels, as proposed by the current European guidelines, which should become legally binding for all EU state members within the current year. With the purpose of reducing potential risks of occupational overexposure, we are developing innovative fabrics for microwave shielding. These new materials are able to attenuate 85% of the microwave radiation. As these are light materials, they can be used in all kind of facilities, as wall covers, movable screens or even as personal protection, like lab clothes or gloves. (Author) 6 refs.

  7. An Assessment of the radiological vulnerability for Spanish soils; Estimacion de indices de vulnerabilidad radiologica para los suelos peninsulares espanoles

    Energy Technology Data Exchange (ETDEWEB)

    Trueba, C.; Millan, R.; Schimid, T.; Lago, C.; Gutierrez, J. [Ciemat. Madrid (Spain)

    2000-07-01

    A methodology is presented to assess the radiological vulnerability of soils, based exclusively on their pedagogical properties. The radiological vulnerability defined as the potential capacity of soils to fix or transfer deposited radiocaesium and radiostrontium to plants, is represented in terms of vulnerability indexes. Two pathways are considered, the external irradiation and their transfer through the food chain, where the top horizon and a critical depth of 60 cm is taken into account, respectively, Partial vulnerability indexes are considered for each pathway, which allows a qualitative prediction of the behaviour of the contaminants in soils Global indexes have been obtained as the sum of the partial indexes. The methodology has been applied and validated using a data base consisting of more than 2000 soil profiles selected from all over Spain. This included a pedagogical characterisation and normalisation of the different soil profiles. Results have been obtained for individual soil profiles and with the aid of a GIS, the distribution of the partial and global indexes have been presented for the most representative soil types. (Author)

  8. Safety requirements and radiological protection for ore installations; Requisitos de seguranca e protecao radiologica para instalacoes minero-industriais

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-06-15

    This norm establishes the safety and radiological protection requirements for mining installations which manipulates, process and storing ores, raw materials, steriles, slags and wastes containing radionuclides of the uranium and thorium natural series, simultaneously or separated, and which can cause undue exposures to the public and workers, at anytime of the functioning or pos operational stage. This norm applies to the mining installations activities, suspended or which have ceased their activities before the issue date of this norm, destined to the mining, physical, chemical and metallurgical processing, and the industrialization of raw materials and residues containing associated radionuclides from the natural series of uranium and thorium, including the stages of implantation, operation and decommissioning of the installation.

  9. Technical support and preparations for the response to radiological emergencies; Soporte tecnico y preparativos para la respuesta a emergencias radiologicas

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas H, J; Ramos V, E O; Fernandez G, I M; Capote F, E; Zerquera J, T; Garcia L, O; Lopez B, G; Molina P, D; Lamdrid B, A I; Benitez N, J C; Salgado M, M [CPHR, Calle 20 No. 4113, e/41 y 47 Playa, CP 11300, La Habana (Cuba); Lopez F, Y; Jerez V, P [CNSN, Calle 28 e/5ta y 7ta, Playa, La Habana (Cuba)

    2006-07-01

    The work picks up the efforts directed to elevate the technical capacity of the answer in front of the radiological emergencies. Expressing them by means of the actions carried out as for teaching, research and development and intervention before accidental radiological events. The same one reflects the leading role of the participant institutions in those marks of the answer system to radiological emergencies that for its technical level it satisfies the national and international demands in the matter. In execution of the mentioned goals research projects guided to endow to the national system of methodologies and procedures for the administration of radiological emergencies have been executed that favor the improvement of its technical and organizational capacities. As well as the postulates of the National Plan of Measures for Case of Catastrophes in the corresponding to radiological accidents. (Author)

  10. The recuperation of the irradiators, support of the radiation protection; La recuperacion de los irradiadores, soporte de la proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Rodriguez, Manuel; Tamayo, Jose Antonio; Gonzalez Rodriguez, Niurka; Villatoro, Mayra; Torres, Alberto; Turruela, Giovany; Gutierrez, Stefan; Vergara, Alex; Acosta, Andy Romero; Chacon, Jorge; Alonso, Gilberto; Ferrera, Eduardo Capote, E-mail: manolo@cphr.edu.cu, E-mail: jotag@cphr.edu.cu, E-mail: niurka@cphr.edu.cu, E-mail: jefelab@mem.gob.gt, E-mail: stefan@cphr.edu.cu, E-mail: alex@cphr.edu.cu, E-mail: andy@cphr.edu.cu, E-mail: jorgechacon@hotmail.com, E-mail: s, E-mail: gilberto@cphr.edu.cu, E-mail: capote@cphr.edu.cu [Centro de Proteccion e Higiene de las Radiaciones (CPHR), La Habana (Cuba). Servicios Electronicos

    2013-07-01

    Recovery of irradiators extend its life and avoid new spending on equipment purchases. Aged technique can still work effectively if it can do the maintenance, rather than a routine, a key priority. In this paper is presented the need of training of new specialists who join secondary laboratories, as well as other less new that did not have the opportunity of specialized training. Advanced knowledge are offered on: security measures to work with irradiators, hot spots that cause breaks in the control panel more frequently, as well as repair and maintenance are reported. It describes how to recover the solenoid with high quality assurance and minimal resources, change font, etc. All have empirical knowledge base.

  11. Importance of the lower limit of detection in radiological safety; Importancia del limite inferior de deteccion en seguridad radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Rafael, Terol T; Hermenegildo, Maldonado M [Comision Nacional de Seguridad Nuclear y Salvaguardias (Mexico)

    1991-07-01

    The concept of the Lower Limit of Detection (LLD) it contributes in the solution of some problems related with the radiological safety, such as the realization of the tests of flight of the sealed radioactive sources; the determination of radioisotopes in environmental samples; the estimate of present radionuclides in polluted foods; in general, the detection of small quantities of radioactive materials present in materials of use or consumption by part of the man in his daily life; as the one Lower Limit of Detection is related with topics of statistics, in this work a small review of them is made, it was superficially discussed the mensuration problems related with the establishment of the Lower Limit of Detection.

  12. Information systems in radiation protection: the INIS database; Sistemas de informacion en proteccion radiologica: la base de datos INIS

    Energy Technology Data Exchange (ETDEWEB)

    Alberdi Larranaga, I.; Marco Arboli, M.

    2011-07-01

    INIS provides a comprehensive service references on literature information on radiation protection (RP), nuclear science and technology, medicine, etc.., Processing most of the world's scientific and technical literature in the area to meet the information needs international community in the areas of interest of the IAEA and the activities related to peaceful use of nuclear science and technology.

  13. The radiological protection in technical-professional level in Mexico; La proteccion radiologica a nivel profesional-tecnico en Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Vizuet Gonzalez, Jorge; Suarez, Gerardo [Instituto Nacional de Investigaciones Nucleares (ININ), Mexico (Mexico). Dept. de Proteccion Radiologica; Corona Montes de Oca, Julia [Centro de Bachillerato Tecnologico ' Justo Sierra' , San Mateo Atenco (Mexico)

    2005-07-01

    This work describes the work done in the implementation of an educational project which aims the formation of technical-professional in radiation protection (RP) with official recognition in Mexico. The constant growth of business activities related to the use of radioactive material in industry, medicine and research has required the development and implementation of standardization by the regulatory authorities of our country. However the advance with regards to training of specialized personnel is reduced in comparison to current needs. in our country there is no technical personnel with studies recognised by the regulatory body in this specialty (RP), however quality assurance programs currently require an educational training that will help to meet the standards in the various activities that develop in the use and handling of sources and ionizing radiation generating equipment, reason why it was developed and implemented this educational project. Additionally induce and promote the need for the peaceful use of nuclear energy and ionizing radiation, at the national level is one more reason to implement the programme at upper secondary level, with the purpose to have knowledge related to the topic. The technical course has a duration of six semesters (three years), and currently there are two generations of graduating. The plan of study consists of the required disciplines for upper secondary level more plus those corresponding to technological training in radiological protection.

  14. National Programme for Radiological Protection in Medical Exposures; Programa nacional de Proteccion radiologica en las exposiciones medicas

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-15

    A national programme on radiation protection of patients can only be effective and sustainable if there is a joint effort between the regulatory body and the health authorities, and a cooperation with educational institutions, professional bodies and representatives of the industry. The regulatory body needs to promote a strategy of cooperation, and to identify obstacles that may prevent compliance with regulatory requirements and to address them. Not of least is the need for a continuous self-evaluation on the efficacy of the programme. Radiation safety of the patients is a responsibility of the users of the radiation sources involved in diagnostic and treatment. In particular, they are responsible for compliance with regulatory requirements. But safety depends also on aspects that are beyond the capabilities of those authorized to conduct practices. These aspects include educational programmes and institutions to implement them, calibration facilities, national protocols, professional bodies for the establishment of reference levels and contributions from the industry. Neither the users nor the regulatory body alone can achieve that these elements are in place. It needs a network of institutions and cooperation arrangements that involve educational and health authorities, laboratory facilities, professional bodies and the industry. A national programme has to include a strategy of cooperation, identification of obstacles that may prevent compliance with regulatory requirements and address them. Not of least is the need for a continuous self-evaluation on the efficacy of the programme. A group of regulatory agencies belonging to the Ibero American Forum of Nuclear and Radiation Regulatory Agency have exchanged experiences, lessons learned and good practices over three years. This exchange included extensive collaboration with the health authorities. The result of this work is this document containing a self-evaluation approach for the regulatory programme on radiation protection and safety in medical exposure.

  15. Preliminary report of radiological safety to hydrology 1993 campaign; Informe preliminar de seguridad radiologica para la campana de hidrologia 1993

    Energy Technology Data Exchange (ETDEWEB)

    Badano, A; Suarez Antola, R; Dellepere, A; Barreiro, M [MIEM, Direccion Nacional de Tecnologia Nuclear, Montevideo (Uruguay)

    1993-07-01

    This report has been prepared based on the interaction between project managers and division radiological Protection and Nuclear Safety. In seeking to establish a basis for approval from the point of view of radiation safety practices . The idea for the audit has been provided at all times because the interest was the exchange of ideas and the use of common sense to improve the safety of radioactive substances, security of operators and public safety and environment.The above shows that in the planned radiation safety condition described in this report,the practice can be carried out according to the criteria of safety accepted .

  16. Efeito de proteses parciais removiveis sobre os tecidos periodontais : estudo clinico e bioquimico

    OpenAIRE

    Fernando Rodrigues Pinto

    2003-01-01

    Resumo: A doença periodontal tem como fator etiológico primário o acúmulo de biofilme dental que pode ser favorecido por uma grande variedade de fatores retentivos locais, como por exemplo próteses parciais, que podem alterar a progressão e o risco da doença. O objetivo deste trabalho foi avaliar o efeito do uso de próteses parciais removíveis (PPRs) sobre as condições clínicas periodontais e alterações qualitativas do biofilme dos dentes suportes. Foram selecionados 15 pacientes de acordo co...

  17. Cervical Tuberculous Lymphadenitis: Clinico-demographic Profiles of Patients in a Secondary Level Hospital of Bangladesh.

    Science.gov (United States)

    Kamal, Mohammad Shah; Hoque, Md Hafiz Ehsanul; Chowdhury, Fazle Rabbi; Farzana, Rubina

    2016-01-01

    Tuberculosis (TB) is a major public health problem in Bangladesh since long. The present incidence and prevalence rates of all forms of TB are 227 and 404/100,000 population respectively. The aim of this study was to find out the clinical characteristics of involved cervical lymph nodes, demographic characteristics of the patients and response to treatment of Cervical Tuberculous Lymphadenitis (CTL) cases. A prospective study was performed in Shaheed Shamsuddin Ahmed Hospital, Sylhet, Bangladesh from June 2012 to June 2014. Total 65 patients having CTL attending outpatient department of the hospital were enrolled. Age of the patients ranged from 5 to 60 years with a mean of 25.6 years. Two third (67.7%) of the patients were female. Male: Female ratio was 1:2.1. More than half of the patients came from rural areas (53.8%) and from low socio-economic conditions (58.5%). Most of the patients presented with unilateral (87.7%), multiple (82.3%), matted (68.6%) lymph nodes, <3cm diameter (54%), commonly in right side (57.9%). Abscess was found in 21.5% cases. Discharging sinus was found in 9.2% cases. Most commonly involved lymph node group was level V (59.4%) followed by level II (42.2%). Systemic features were found in 63.07% patients. Associated lung lesion was found in 3.1% cases. FNAC was found positive for tuberculosis in 83.9% cases. Most of the patients (78.46%) were cured with six months anti-tubercular chemotherapy. Early diagnosis and treatment is critical in reducing the overall prevalence. It is essential to have awareness regarding common presentations of cervical tuberculous lymphadenitis among the general population as well as healthcare professionals working in the resource poor primary and secondary level hospitals.

  18. Focal parenchymal lesions in community-acquired bacterial meningitis in adults: a clinico-radiological study

    International Nuclear Information System (INIS)

    Katchanov, Juri; Siebert, Eberhard; Klingebiel, Randolf; Endres, Matthias

    2009-01-01

    Here, we analyzed the frequency, morphological pattern, and imaging characteristics of focal lesions as a consequence of community-acquired bacterial meningitis. We hypothesized that diffusion-weighted imaging combined with contrast-enhanced imaging, serial scanning, and multimodal vascular studies would provide further insight into the pathological basis of such parenchymal lesions in bacterial meningitis. We reviewed clinical and imaging data (i.e., magnetic resonance tomography, magnetic resonance angiography, computed tomography angiography, digital subtraction angiography) of 68 adult patients admitted to our neurological intensive care unit between March 1998 and February 2009 with the diagnosis of community-acquired bacterial meningitis. We identified seven patients with parenchymal lesions. These lesions could be attributed to four morphological patterns: (1) territorial cerebral ischemia, (2) perforating vessels ischemia, (3) ischemia of presumed cardiac origin, and (4) isolated cortical lesions. Whereas the patterns (1) and (2) were associated with vasculopathy of large- and medium-sized vessels (as shown by cerebral vascular imaging), vessel imaging in (3) and (4) did not show abnormal findings. Our study implies that parenchymal lesions in acute bacterial meningitis are mainly ischemic and due to involvement of large-, medium-, and small-sized arteries of the brain. Diffusion-weighted imaging combined with conventional, CT-, or MR-based cerebral angiography revealed the underlying pathophysiological mechanisms in the majority of patients. Furthermore, we detected two patients with isolated bilateral cortical involvement and normal vessel imaging. These lesions might represent ischemia due to the involvement of small pial and intracortical arteries. (orig.)

  19. Le benzodiazepine nel trattamento dell’ansia: profilo clinico e farmacoeconomico

    Directory of Open Access Journals (Sweden)

    Barbara Cascio

    2005-12-01

    Full Text Available Anxiety disorders impose a significant economic burden on healthcare system, patients and society as a whole. A patient with anxiety disorders, especially with panic disorder, shows some difficulties to work or to maintain an acceptable social functioning, and, frequently, needs more medical care than a normal subject, often due to unnecessary or inappropriate diagnostic tests. Adequate psychiatric treatment of anxiety disorders can lead to higher direct specialists costs (psychiatric drugs and visits but this may be offset by a decrease in non-specialist care costs and in indirect costs. Benzodiazepines have been extensively used for the treatment of anxiety and related disorders since the 1960s. Although new pharmacological and psychological treatments for anxiety are available, a lot of psychiatrists continue to endorse benzodiazepines as primary or adjunctive treatment for these disturbs, especially in the early or acute phases of the illness. In Italy, benzodiazepines have been available also as generic drugs for some years. In order to be accepted for marketing, a generic drug has to demonstrate bioequivalence, considered a reliable proxy of therapeutic equivalence, with the standard formulation and its price has to be at least 20% cheaper than the originator drug. The use of generic drugs can contain drug expenditures and facilitate a competitive market. Despite that their prices are considerably higher than those of generics, branded benzodiazepines are still widely prescribed, because of prejudices and lack of information in the community of physicians and patients. In conclusion, benzodiazepines may treat anxiety disorders, mainly in early and acute phases, increasing quality of life and saving medical resources. The availability of generics allows for marginal reduction in initial investment in drug costs.

  20. Scrub Typhus: A Clinico-Laboratory Differentiation of Children with and without Meningitis.

    Science.gov (United States)

    Bhat, Nowneet Kumar; Pandita, Neerul; Saini, Manju; Dhar, Minakshi; Ahmed, Sohaib; Shirazi, Nadia; Wasim, Sanober; Shirke, Rupali; Chandar, Vipan

    2016-06-01

    Neurological involvement in the form of meningitis or meningoencephalitis, although well documented in scrub typhus, has not been extensively studied in the pediatric population. We report the clinical and laboratory profile of 96 children with scrub typhus and compared those with and without meningitis. Twenty seven (28%) children had clinical and laboratory evidence of meningitis. The most frequent presenting features were fever (100%), meningeal signs (66.6%), nausea and vomiting (56.3%), seizures (55.5%) and altered sensorium (51.8%). The children with meningitis presented early and had significantly lower respiratory and renal impairments when compared with the non-meningitis group. Cerebrospinal fluid (CSF) analysis revealed elevated total leukocyte count (86.73 ± 94.50 cells/mm(3)), mononuclear pleocytosis (lymphocyte percentage of 76.85 ± 15.86), elevated proteins (108.33 ± 52.63 mg%) and normal CSF glucose (64.18 ± 15.92 mg%). We conclude that meningitis is a common and early complication of childhood scrub typhus. The CSF reveals a lymphocytic pleocytosis, raised proteins and a normal glucose level. These children respond promptly to appropriate antibiotics as do children without meningitis. © The Author [2016]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. Clinico-psychological analysis of systematic (vestibular and nonsystematic (psychogenic vertigo, therapy optimization

    Directory of Open Access Journals (Sweden)

    Elena Mikhailovna Illarionova

    2011-01-01

    Full Text Available Objective: to study the clinical and psychoemotional characteristics in patients with systematic and nonsystematic vertigo and to optimize therapy. Patients and methods. The clinical features were analyzed in 25 patients with systematic vertigo and 25 patients with psychogenic vertigo. Their psychoemotional sphere was studied using the Beck depression inventory, the Spielberger-hanin personality- and situation-related anxiety inventory, and the vestibular inventory. Results. There were statistically significant clinical differences and a higher degree of anxiety-depressive disorders in the patients with psychogenic vertigo. Drug therapy in combination with stabilometric platform exercises based on the biological feedback principle was stated to be effective in patients with different types of vertigo, in those with psychogenic dizziness in particular.

  2. Clinico-epidemiologic Study on Marine Envenomations and Injuries in South Iran, Persian Gulf Coasts

    Directory of Open Access Journals (Sweden)

    Iraj Nabipour

    2015-09-01

    Conclusion: Scorpionfish attacks are the common cause of marine animal exposures in south Iran and should be taken seriously. Men at young ages are the victims of this environmental and occupational hazard.

  3. Encefalitis a citomegalovirus en un paciente inmunocompetente: análisis clinico, neuropatologico y ultraestructural

    Directory of Open Access Journals (Sweden)

    Salamano Ronald

    2001-01-01

    Full Text Available Las encefalitis por citomegalovirus en pacientes inmunocompetentes son excepcionales, siendo un patógeno reconocido en pacientes inmunodeprimidos (SIDA, transplantados. Se reporta el caso clínico de una encefalitis por Citomegalovirus en un adulto joven, sin evidencia de enfermedad inmunosupresora, cuyo diagnóstico fue posible mediante la detección de ADN viral en la biopsia cerebral. Se describen además las singularidades clínicas de este caso y los hallazgos de la anatomía patológica y de la microscopía electrónica comparándolos con los reportados en pacientes inmunodeprimidos.

  4. [The clinico-epidemiological premises for antioxidant prevention and treatment in chronic myocardial infarct].

    Science.gov (United States)

    Azoicăi, D; Mitu, F; Iacobovici, A; Pavel, M; Jerca, L; Ungureanu, D; Popovici, I; Cojocaru, M; Ivan, A; Gheorghiţă, N

    1996-01-01

    The improvement of therapeutic and recoverable proceeding to chronic myocardial infarction (IMC) imposes a complex epidemiological estimation of the global cardiovascular risk, of their clinical and biological status. The retrospective evaluation of the risk factors (RF) by epidemiological methods, in 38 hospitalized prevalence of both constitutional and behavioral factors, and the quantification of the risk state, according to graph Euro 194, has pointed on the fact that 50% of IMC cases have presented a global risk of 10-20%. That justified the application of a preventive conduct in order to continually neutralize the associates FR. The biochemical determinations have allowed to frame the dyslipidemic patients, according to the ARCOL classification in the classes D (29.2%), E (25.0%) and B (20.8%) with direct implication in the adopted therapy. The colorimetric dozing with thyo-barbituric acid of the malonly dialdehyde (MAD) each is a product of the lipidic peroxidation, as well as the interpreting or correlation of the registered values with an evolutive clinic stage, and with the existence of some existing diseases (diabetes, chronic hepatitis etc.) along with signification of other dismethabolical parameters (cholesterol, triglycerides, LDLc, apoB) have confirmed the necessity of a complex therapy, including an antioxidative treatment, having the role to directly inhibit or exclude the free radicals resulted after the oxidative stress of the infarct.

  5. Clinico-Pathological Profile and Management of Acute Mechanical Small Bowel Obstruction: A Prospective Study

    Directory of Open Access Journals (Sweden)

    Tahir Saleem Khan

    2013-06-01

    Conclusion: Abdominal pain and distention of the abdomen are the most common symptoms and physical findings in patients presenting with acute mechanical small bowel obstruction (SBO. Worm (ascaridial obstruction is the most common cause of obstruction followed by postoperative adhesions. Although all patients were managed conservatively to start with, the operative rate in our series remained very high because it is very difficult to distinguish simple from strangulation obstruction on clinical, biochemical and/or radiological grounds with certainty. [Arch Clin Exp Surg 2013; 2(3.000: 154-160

  6. [Intraoperative lactic acidosis, can it be treated? Clinico-experimental, prospective, sequential study].

    Science.gov (United States)

    Pietropaoli, P; Caporelli, S; De Pace, F; Donati, A; Adrario, E; Luzi, A; Munch, C; Giovannini, C; Frezzotti, A R

    1994-12-01

    To verify the efficacy and absence of risk attributable to therapy with alkaline solutions for correction of lactic acidosis and to demonstrate the usefulness of L-carnitine in converting lactate into pyruvate in conditions of good blood oxygenation. Prospective study on a consecutive series of patients subdivided into three groups following the use of: alkalinizing therapy (group I), L-carnitine (group II), or saline solution (group III). Groups 1 and 2 were further subdivided into subgroups "a" and "b" according to the type of alkalinizing agent and of L-carnitine somministration. Teaching Hospital-Torrette di Ancona. 65 patients submitted to major vascular surgery with aortic clamping in the time period between January 1992 and August 1993. During aortic clamping patients of: group I received 2 mEq:kg of bicarbonate or tromentamolo according to the specific subgroup. Group II received a bolus of 2 g of L-carnitine, patients of group IIb received further 2 g of carnitine in continuous perfusion until the end of surgery. Group III received no pharmacological intervention. HR BP, arterial blood gases and lactic acid levels were measured at 12 pre-determined times. Only a neutralizing effect of alkalinizing therapy was observed, whereas the lactic acid measurements demonstrated no significant differences between the different groups. These results confirm the data of other Authors concerning the good compliance of alkalinizing therapy, however, there was demonstrated no clear evidence of its effective usefulness. No metabolic stimulation due to L-canitina could be demonstrated in our experimental conditions.

  7. Bacterial Viability within Dental Calculus: An Untrodden, Inquisitive Clinico-Patho- Microbiological Research.

    Science.gov (United States)

    Gupta, Swati; Jain, P K; Kumra, Madhumani; Rehani, Shweta; Mathias, Yulia; Gupta, Ramakant; Mehendiratta, Monica; Chander, Anil

    2016-07-01

    Chronic inflammatory periodontal diseases i.e. gingivitis and periodontitis are one of the most common afflictions faced by human beings. Dental plaque, which is a pool of pathogenic microorganisms, remains to be current mainstay in etiopathogenesis. Dental calculus, which is a mineralized product of this plaque remains ignored and is considered merely as an ash heap of minor significance. However, the intriguing array in disease etiopathogenesis bulldozed researchers to suspect the role of calculus in disease chrysalis but still the viability of bacteria inside calculus and thus its pathogenicity remains an intricacy; the answer to which lies in the Pandora's Box. The present study was undertaken to investigate the viability of bacteria within dental calculus along with their identification. Also, to classify dental calculus on the basis of mineralization and to observe the variation of viable microflora found in dental calculus with the extent of mineralization and disease severity. A total of 60 samples were obtained, by harvesting two samples of supragingival calculus from each patient having chronic inflammatory periodontal disease. These samples were divided into two groups (Group A and Group B). Samples of Group A were kept non-irradiated and samples of Group B were exposed to UV radiation. The samples were categorized into less, moderately and highly mineralized according to the force required for crushing them. All the crushed calculus samples were then divided into three parts. These were used for dark-field microscopy, gram staining and bacterial cultures. Bacterial identification of the cultures obtained was also carried out by performing various biochemical assays. The present study revealed the presence of motile spirochaetes within the samples under dark-field microscope. Gram staining revealed presence of numerous gram positive cocci and gram negative bacilli. Bacterial cultures showed growth of variety of aerobic and capnophilic microorganisms. The present study concludes the presence of viable aerobic and capnophilic bacteria inside dental calculus which may reside within the lacunae and channels in the calculus.

  8. Aerosol, a health hazard during ultrasonic scaling: A clinico-microbiological study

    Directory of Open Access Journals (Sweden)

    Akanksha Singh

    2016-01-01

    Conclusions: The aerosols and splatters produced during dental procedures have the potential to spread infection to dental personnel. Therefore, proper precautions should be taken to minimize the risk of infection to the operator.

  9. Clinico-radiological features of subarachnoid hyperintensity on diffusion-weighted images in patients with meningitis

    International Nuclear Information System (INIS)

    Kawaguchi, T.; Sakurai, K.; Hara, M.; Muto, M.; Nakagawa, M.; Tohyama, J.; Oguri, T.; Mitake, S.; Maeda, M.; Matsukawa, N.; Ojika, K.; Shibamoto, Y.

    2012-01-01

    Aim: To investigate the clinical and radiological features of meningitis with subarachnoid diffusion-weighted imaging (DWI) hyperintensity. Materials and methods: The clinical features, laboratory data, and radiological findings, including the number and distribution of subarachnoid DWI hyperintense lesions and other radiological abnormalities, of 18 patients seen at five institutions were evaluated. Results: The patients consisted of eight males and 10 females, whose ages ranged from 4 months to 82 years (median 65 years). Causative organisms were bacteria in 15 patients, including Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Klebsiella pneumoniae, and Listeria monocytogenes. The remaining three were fungal meningitis caused by Cryptococcus neoformans. Subarachnoid DWI hyperintense lesions were multiple in 16 of the 18 cases (89%) and predominantly distributed around the frontal lobe in 16 of the 18 cases (89%). In addition to subarachnoid abnormality, subdural empyema, cerebral infarction, and intraventricular empyema were found in 50, 39, and 39%, respectively. Compared with paediatric patients, adult patients with bacterial meningitis tended to have poor prognoses (7/10 versus 1/5; p = 0.1). Conclusion: Both bacterial and fungal meningitis could cause subarachnoid hyperintensity on DWI, predominantly around the frontal lobe. This finding is often associated with poor prognosis in adult bacterial meningitis.

  10. Enfermeiro Clinico Especialista: um modelo de pratica avancada de enfermagem em oncologia pediatrica no Brasil

    Directory of Open Access Journals (Sweden)

    Carla goncalves Dias

    2013-12-01

    Full Text Available O objetivo deste artigo é relatar a experiência de implantação do modelo de prática avançada de enfermagem por meio da incorporação do enfermeiro clínico especialista na composição do quadro de enfermagem. As autoras apresentam o conceito desse modelo e descrevem seu processo de implantação em uma instituição de referência no cuidado à criança e ao adolescente com câncer da cidade de São Paulo, Brasil. Na avaliação das enfermeiras clínicas especialistas, o principal resultado obtido com a adoção do modelo refere-se ao fortalecimento do papel do enfermeiro como profissional de referência para a articulação das diferentes demandas de cuidado à criança, ao adolescente e ao adulto jovem com câncer e sua família. Também destacam a satisfação dos usuários com o estreitamento da relação paciente, família e enfermeira clínica, em todas as etapas do processo de cuidar.

  11. A clinico-radiologic study of bony remodeling of the fractured condyles in children

    International Nuclear Information System (INIS)

    Cho, Jeong Shin; Park, Chang Seo

    1995-01-01

    Bony remodeling pattern of condyle fractures in children are different from in adult for growing of condyle, also might affect treatment and prognosis of the condyle fracture. Subjects of this clinical and radiologic study were 26 temporomandibular joints diagnosed as condyle fracture in 23 patients under 15 years old age, They were treated with conservative method at Dental Hospital of Yonsei University from Jan., 1986 to Oct., 1994. Bony remodeling related with fracture pattern was evaluated. The results obtained are as follows: 1. The ratio of male to female in patients with condyle fracture was 1 : 0.9 and the difference of sex ratio was not noted. Comparing with preschool-age group and school-age group, age frequency was higher in preschool-age group (83%). 2. Fallen down (54%) was the most frequent cause of condyle fractures. Traffic accident and slip down were followed. 3. The most common clinical sign of condyle fractures was tenderness to palpation (19 cases). Mouth opening limitation (17 cases), swelling (7 cases), malocclusion (3 cases) were next in order. 4. According to sites of condyle fractures, unilateral fractures were in 20 patients and bilateral fractures in 3 patients, therefore total 23 patients-26 cases of condyle fracture were observed. According to fracture distribution, condyle fractures were in 10 patients (44%). Condyle fractures with symphysis fracture (9 patients, 39%), condyle fractures with ascending ramus fracture (2 patients, 9%), condyle fracture with mandibular body fracture (1 patient, 4%), and condyle fractures with mandibular angle fracture (1 patient, 4%) were followed. 5. In displacement pattern of fractured fragment of mandibular condyle, displacement (17 cases, 66%) was most common. Dislocation (5 cases, 19%) and deviation (4 cases, 15%) were next in order. 6. During the observation period of fractured condyles, remodeling patterns of fracture sites related with articular fossa were observed with usual congealer shape in 23 cases and with prominently different shape in 3 cases.

  12. Clinico-morphological correlations in the categorization of holes between the ventricles

    Directory of Open Access Journals (Sweden)

    Friedman Brad

    2010-01-01

    Full Text Available Controversy still exists in the categorization of holes between the ventricles, although they are the most common congenital cardiac malformation. Advanced imaging techniques such as three-dimensional echocardiography and computed tomographic angiography offer superb anatomical details of these defects. In this review, we have sought to collate the features highlighted in different categorizations and identify their similarities, but also emphasize their differences. We hope that an analysis of this type, now achievable during life, using advanced imaging, might lead to the appearance of a unified system for diagnosis and description of holes between the ventricles.

  13. CLINICO-PATHOLOGICAL OBSERVATIONS OF PIGEONS (COLUMBA LIVIA SUFFERING FROM NEWCASTLE DISEASE

    Directory of Open Access Journals (Sweden)

    S. Shaheen, A. D. Anjum and F. Rizvi

    2005-01-01

    Full Text Available A survey was conducted to study clinical signs, gross and histopathological lesions in pigeons with naturally occurring Newcastle disease. For this purpose, 30 pigeon lofts were visited. Among these, 14 lofts showed clinical signs of Newcastle disease, including mainly greenish white mucoid diarrhoea and nervous signs with high morbidity and mortality. Postmortem examination of affected birds showed lesions mainly in brain, liver, kidneys and spleen. Amongst various organs, kidneys were more frequently involved. Histopathological changes were also observed in lungs, liver, kidneys, brain and spleen. The results showed that the Newcastle disease virus was widespread in pigeons locally and caused heavy mortality. No preventive measures or vaccination is being adopted by pigeon fanciers to control the disease.

  14. Dating of Early Subdural Haematoma: A Correlative Clinico-Radiological Study

    Science.gov (United States)

    Rao, Murali Gundu; Khandelwal, Niranjan; Sharma, Suresh Kumar

    2016-01-01

    Introduction Determination of post-traumatic interval remains one of the foremost important goals of any forensic investigation related to human crimes. The estimation of time since injury in cases of subdural haemorrhage has been studied only by a few investigators on the histological and radiological front. Aim The purpose of this study was to determine the post-traumatic interval of Subdural Haemorrhage (SDH) based on Hounsfield Unit measurements (HU) on Computed Tomography (CT) in surviving victims of head injury. Materials and Methods The study included a total of 100 cases of closed head injury with subdural haemorrhage. The Post-traumatic Time Interval (PTI) varied from 0.5 hours to a maximum of 249 hours, with a mean of 54.2 hours. Results Statistically significant results were obtained between the HU measurements of the SDH and the post-traumatic intervals and were found to be statistically significant. A rough attempt was made to determine the effect of haematoma volume on attenuation and was found out to be statistically insignificant. Conclusion The density of the subdural haematoma decreases with increase in the post-traumatic interval that concurs with the limited number of studies being conducted in the past. We concluded that further sorting of cases could be done according to its age with additional research and uniformity in the methodology. PMID:27190831

  15. Virological and clinico-pathological features of orf virus infection in experimentally infected rabbits and mice.

    Science.gov (United States)

    Cargnelutti, J F; Masuda, E K; Martins, M; Diel, D G; Rock, D L; Weiblen, R; Flores, E F

    2011-01-01

    Many aspects of the biology of orf virus (ORFV) infection remain poorly understood and attempts to establish animal models have yielded conflicting and non-reproducible results. We herein describe the characterization of ORFV infection and disease in rabbits and mice. A protocol of intradermal inoculation was employed to inoculate 10(8.5)TCID₅₀/mL of ORFV strain IA-82 in the skin of ears, of the back and labial commissures. All inoculated rabbits presented a clinical course characterized by erythema, macules, papules/vesicles or pustules that eventually dried originating scabs. Local signs started around days 3 and 4 post-inoculation (pi) and lasted 3-10 days. Virus was recovered from lesions between days 2 and 14pi. Histological examination of lesions revealed focal proliferative dermatitis with ballooning degeneration and eosinophilic intracytoplasmic inclusion bodies in keratinocytes, histological hallmarks of contagious ecthyma in sheep. A similar, albeit milder clinical course occurred in 5/10 inoculated mice; virus was recovered from lesions from three animals. Inoculated lambs - used as controls - developed severe lesions of contagious ecthyma. VN tests performed at day 28pi failed to detect neutralizing antibodies in all inoculated animals. In contrast, convalescent rabbit sera were positive by ELISA at dilutions from 100 to 400. These results show that rabbits are susceptible to ORFV infection and thus may be used to study selected aspects of ORFV biology. Copyright © 2010 Elsevier Ltd. All rights reserved.

  16. Trial production of x-ray protective coat in clinico-orthodontics and evaluation of efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Fukui, H; Nezu, F; Arita, M; Numata, K; Nishioka, T [Nihon Univ., Tokyo. School of Dentistry

    1977-09-01

    The authors produced for trial an x-ray protective coat for patients which could be used for any type of dental roentogenography particularly by clinicoorthodontists and could easily exert a sufficient protective effect. The trial product is of coat type covering the front, sides, and back of the trunk and is made of vinyl sheet containing lead and rubber sheet containing lead. When patients put on the coat during cephalography, the internally absorbed dose was decreased greatly in the back corresponding to the 7th cervical vertebra and the area of thyroid and considerably in the area of right joint and the area corresponding to the center of the sternal shaft. The protective effect of the coat was also great in ortho-pantomography in regions corresponding to hemopoietic tissues abundant in bone-marrow, such as the areas of bilateral joints the back corresponding to the 7th cervical vertebra, and the area corresponding to the center of sternal shaft. Internally absorbed doses in different regions due to various types of roentgenography were tabulated. The x-ray protective coat was described to be useful not only in orthodontics but also in roentogenography in the craniocervical region.

  17. Clinico-Epidemiological Profile And Factors Affecting Severity Of Atopic Dermatitis In North Indian Chilldren

    Directory of Open Access Journals (Sweden)

    Sarkar Rashmi

    2004-01-01

    Full Text Available Atopic dermatitis (AD is a chronic, relapsing dermatitis commonly affecting children. Various epidemiologic factors and clinical patterns of the same were evaluated in 125 patients out of 418 attending the pediatric dermatology clinic over a period of 11/2 years. Of these, 26 were infants (upto 1 year of age and 99 were children. Mean duration of the disease in the infantile group was 3 months while in the childhood group it was 6 years. In the infantile group, family history of atopy was found in 11 patients (42.3%, while in the childhood group 35 (35.35% had family history of atopy, 7 (7.07% had personal history of atopy and 2 (2.02% had both personal and family history of atopy. The infantile group had more frequent facial involvement and acute type of eczema, while in the childhood type, site involvement was less specific and chronic type of eczema was more frequent. Most of the patients had mild to moderate degree of severity of the disease.

  18. [Non-neoplastic enlargement of salivary glands: clinico-histologic analysis].

    Science.gov (United States)

    González Guevara, Martha Beatriz; Torres Tejero, Marco Antonio; Martínez Mata, Guillermo

    2005-01-01

    We carried out a retrospective study on non-neoplastic enlargement of the salivary glands at the Oral Histopathology Diagnostic Center of the Autonomous Metropolitan University at Xochimilco (UAM-Xochimilco) in Mexico during a period of 24 years (1979-2003). From 5,625 biopsies received and analyzed, a total of 461 (8.2%) were non-neoplastic enlargement of the salivary glands; for each case, we registered demographic data as well as clinic characteristics. These lesions were characterized as a heterogeneous group of pathologic entities among which we included local, obstructive, infectious, and immunopathologic lesions. The most frequent lesion was the extravasation cyst in 341 (74%) cases, followed by chronic sialoadenitis and Sjögren's syndrome with 54 (11.7%) and 41 (8.8%) cases, respectively, and at a lesser percentage mucous retention cyst, sialosis, benign lymphoepithelial lesions and those related with sialolytes. Females were affected more frequently; mean age was second to third life decades. These lesions were most frequently localized on inferior labial mucosa.

  19. Characteristics of Clinico-pathologic Presentations of Chronic Gastroduodenitis in Children with Lambliasis Invasion

    Directory of Open Access Journals (Sweden)

    Matveeva O.V.

    2012-03-01

    Full Text Available The analysis of anamnestic and clinical indices, and also morphological investigation of biopsy materials of mucous coat of stomach and duodenum in children with chronic gastroduodenitis of different etiology including lambliasis invasion is carried out with the purpose of detecting features of clinicopathologic presentations of chronic gastroduodenitis in children with and without lambliasis invasion. Material and methods. 100 patients (50 children with confirmed lambliasis invasion and 50 patients without lambliasis invasion aged from 2 up to 16 were under observation. The material for histologic study was received as a result of fibrogastroduodenoscopy carried out with target biopsy of fundic, antrum and duodenum mucosa. Results. As a result of the findings moderate pains sited in epigastric and periumbilical regions are characteristic for children with lambliasis invasion; irradiation and cramping characteristics of pains are typical. Conclusion. Manifestation of pains is not connected with the time of day and food intake, manifestation of seasonal prevalence is not typical as well, and progression of inflammatory process in the mucous coat of the stomach and duodenum is declared itself as a diffuse gastritis of the fundic part, a diffuse gastritis of the antral part, subatrophic duodenitis with cyst formation of Brunner's glands, and also the presence of eosinophilic leucocytes in the cellular infiltrate

  20. [Clinico-psychological features of patients with favorable outcomes of slowly-progressive juvenile schizophrenia].

    Science.gov (United States)

    Tsutsul'kovskaia, M Ia; Bil'zho, A G; Kritskaia, V P; Meleshko, T K

    1986-01-01

    A follow-up study of patients with favourable outcomes of juvenile slowly progressing schizophrenia at the level of clinical cure (n = 84) revealed a number of clinical characteristics in the pattern of personality changes which correlated with a high level of the patients' social and occupational adaptation. The authors also determined external factors contributing to the achievement and stabilization of the "clinical cure" status. An experimental and psychological examination of these patients revealed finer mechanisms contributing to their social adaptation. These are high motivation of activities, compliance with social norms, a high level of voluntary regulation of activity and self-regulation, as well as the ability to overcome autistic trends in situations of interpersonal activities and cooperation.

  1. Prevalence and Clinico-Pathology of Ketosis in Dairy Cows in Tigray ...

    African Journals Online (AJOL)

    The clinical observations in ketotic cows were anorexia, refusal to take concentrate and decrease in milk yield. There was 30-100% decrease in milk yield in most of the cases. The body temperature, pulse and respiration rates were within normal range with decreased rumen motility. Feces were scanty, mucoid and dry; and ...

  2. [The clinico-epidemiological characteristics of cholera patients in Mexico City].

    Science.gov (United States)

    Vilchis-Guizar, A E; Uribe-Márquez, S; Pérez-Sánchez, P L

    1999-01-01

    To compare the clinical and epidemiological characteristics of cholera patients and patients with diarrhea of different etiology (controls), treated at Mexican Institute of Social Security medical units in northeast Mexico City, from 1995 to 1998. Cross-sectional analytical study design. Data were collected using the official form "Immediate Notification of Cholera Cases" that each medical unit reports to the Coordination of Community Health. Statistical analysis consisted of comparisons of means and proportions between both groups. In 4,952 notifications, there were 588 cholera cases and 4,364 controls. The age range of cases was 39 to 51 years and 54% were females. During 1995 and 1997 (years with higher proportion of cases) patients with cholera had a greater frequency of watery evacuations than controls (97% vs. 73%), "rice water" appearance (31% vs. 13%), vomiting (72% vs. 63%), muscular spasms (49% vs. 26%), dehydration (83% vs. 71%), hypovolemic shock (10% vs. 1%) and death (0.85% vs. 0.25%). These differences were statistically significant. Cholera presents a biannual cyclic behavior; greater frequencies are associated with greater severity and complications. It is necessary to increase epidemiologic surveillance and medical efforts for opportune diagnosis and treatment.

  3. Ceratolise escavada : contribuição ao estudo clinico e etiopatogenico

    OpenAIRE

    Francisco Adão da Fonseca

    1988-01-01

    Resumo: A Ceratolise escavada foi descrita por Castellani em 1910. Desde então surgiram diversas descrições, discordantes quanto a nomenclatura, conceitos etiopatoginicos e clínicos, e significado dos microrganismos observados nas lesões. Além de organismos cocofilamentosos não identificados, foram individualizados: Corynebacterium, Dermatophilus congolensis e Micrococcus sedentarius. Para esclarecer estes aspectos, prepusemo-nos a 1. rever a literatura para reconhecer o padrão clínico clássi...

  4. [The clinico-neuropsychological aspects of arteriovenous malformations of the hippocampus].

    Science.gov (United States)

    Buklina, S B; Filatov, Iu M; Eliava, Sh Sh

    1998-01-01

    A comprehensive examination was made in 39 patients with arteriovenous malformations (AVM) of hippocampus. Prior to and following surgery, all the patients underwent neuropsychological study after A. R. Luriia (1962). Mnestic disorder was found to be the most common abnormality in patients with AVM at this site. Before surgery, they were detected in 34 of 39 patients, 11 of them having severe memory disorders with the traits of the Korsakoff's syndrome. These patients were found to have mixed posthemorrhagic lesion of the hippocampus, other portions of the temporal lobe and periventricular structures. Twenty nine patients were operated on, 14 of them had progressive mnestic disorder of the modally nonspecific type irrespective the side operated on. There were no postoperative Korsakoff's syndromes. There was no progression in memory defects in patients after surgery on the brain drastically changed after hemorrhage or removal of minor malformations. Before hemorrhage, epileptic paroxysms were observed in 2 of the 39 patients only in the presence of massive AVM obligatorily involving the temporal cortex. Following surgery, there were no new epileptic paroxysms and changes in the emotional status and motivations in the patients. Thus, the hippocampal formation is involved in the primary mechanisms of fixation, retention, reproduction of a memory trace. The participation of many structures of the brain is required to form an emotional status, motivation, and clinical manifestations of epileptic activity.

  5. clinico-pathologic review of biopsied tongue lesions in a nigerian

    African Journals Online (AJOL)

    diagnosis.4 Most studies that reviewed tongue lesions were based on clinical ... on habit, class of the lesion, histological diagnosis, age, gender and site of lesions ..... relate to histone modification, expression, and cancer. Carcinogenesis.

  6. CLINICO-HAEMATOLOGICAL STUDY OF CHRONIC KIDNEY DISEASE IN A TERTIARY CARE CENTRE

    Directory of Open Access Journals (Sweden)

    Parvathi Gorla

    2016-08-01

    Full Text Available BACKGROUND Chronic kidney disease (CKD is a major public health problem causing significant morbidity and mortality worldwide. Diabetes mellitus (DM and hypertension are common causes and anaemia is a common complication. It is important to identify the cause and complication, to treat it and prevent its progression to end-stage renal disease (ESRD. AIM To identify the haematological pattern in chronic kidney disease patients and to study the clinical presentation. MATERIALS AND METHODS 72 cases of CKD were studied for a period of 6 months and thorough assessment of clinical features and haematological examinations were done. RESULTS CKD is observed in all age groups and predominantly in older age group greater than 50 yrs., with male preponderance. DM and hypertension are common causes. 89% of the patients presented with anaemia and 4 cases of sickle cell anaemia were observed. Neutrophilic leucocytosis was seen in 29.2% and thrombocytopenia in 8.3% of cases. CONCLUSION CKD is seen in all age groups with a male predominance, common in older age group, anaemia being the most common and important haematological complication. Few cases of sickle cell anaemia (SCA were seen presenting with CKD. Knowledge and treatment of these conditions has proved to improve the quality of life.

  7. CLINICO-HAEMATOLOGICAL STUDY OF PANCYTOPENIA IN A TERTIARY CARE CENTRE

    Directory of Open Access Journals (Sweden)

    Sanapala Sridevi

    2018-01-01

    Full Text Available BACKGROUND Pancytopenia is one of the pathological manifestation resulting from various underlying disease processes affecting the bone marrow. Hence, bone marrow examination is the diagnostic tool to detect the underlying aetiology of pancytopenia. Pancytopenia nowadays has become a relatively common haematological entity. The underlying cause is ranging from simple drug-induced bone marrow hypoplasia, megaloblastic anaemia to fatal bone marrow aplasias and leukaemias. Thus, identification of the correct cause will help in implementing appropriate therapy. MATERIALS AND METHODS This was a prospective study and 158 pancytopenic patients were evaluated clinically along with haematological parameters and bone marrow aspiration in Clinical Pathology, Department of Pathology, during the period of December 2016 to December 2017. RESULTS Among 158 cases, age of patients ranged from 3 to 88 years with a mean age of 45 years and male predominance. Most of the patients presented with fever and anaemia. The commonest physical finding was pallor followed by generalised weakness and splenomegaly. Dimorphic anaemia was the predominant blood picture. Among the 158 cases, 56 cases have undergone bone marrow aspiration in the department. The commonest bone marrow finding was erythroid hyperplasia with megaloblastic maturation (25%. CONCLUSION The present study shows the detailed primary haematological investigations along with bone marrow aspiration in pancytopenia patients, which is useful in understanding disease process. These are also helpful in planning further evaluation and management.

  8. Allergic fungal sinusitis: clinico-pathological aspects. Findings on CT and MR

    International Nuclear Information System (INIS)

    Romero, A.; Bueno, A.; Conde, M. A.; Trigo, J. E.

    1999-01-01

    Allergic fungal sinusitis (AFS) represents the most recently described form of chronic sinusitis caused by fungi. It occurs in affects teenagers and young adults with atopic antecedents. This disease is a non-invasive chronic sinusitis, fungus acts as the allergen, causing a host immune response, mediated by type I and III reactions. Typically, several paranasal sinuses are usually involved with unilateral predominance. Most common clinical findings are headache, different grades of nasal obstruction and proptosis. Diagnostic criteria have been proposed for this entity, including imaging findings obtained with computed tomography (CT). Computed tomography and magnetic resonance imaging findings together have recently been postulated as practically pathognomonic. Treatment and prognosis of this entity, different from other types of fungal sinusitis, makes important to achieve a correct diagnosis. On this task, imaging studies as CT and MR play an important role. (Author) 23 refs

  9. Skin Cancer: ClinicoPathological Study of 204 Patients in Southern Governorates of Yemen.

    Science.gov (United States)

    AlZou, Amer Bin; Thabit, Mazen Abood Bin; AlSakkaf, Khalid Abdulla; Basaleem, Huda Omer

    2016-01-01

    Skin cancer is a group of heterogeneous malignancies, in general classified into nonmelanoma skin cancer (NMSC) and melanoma skin cancer (MSC). Incidences are high in many parts in the world with considerable geographical and racial variation. In the Yemen, there has been scarce information about skin cancer. The aim of this study was to evaluate the demographic characteristics and histological trend of skin cancer in Southern Governorates of Yemen. This retrospective study covered 204 cases of skin cancer at the Modern Histopathology Laboratory and Aden Cancer Registry and Research Center, Faculty of Medicine and Health Sciences, University of Aden, for the period 20062013. Data were classified regarding different demographic and tumor related variables and analyzed using CanReg4 for cancer registry and SPSS (version 21). The commonest encountered skin cancer was NMSC (93.1%). Generally, skin cancer appears slightly more frequently in females than males with a 1:1.06 male: female ratio, with a mean age of 62.9 years. Slightly higher than onethird (36.3%) were from Aden governorate. The head and neck proved to be the most common site in both males and females (58%). Basal cell carcinoma (BCC) is the most common histological type of skin cancer (50.5%). Skin cancer is a common cancer in patients living in southern governorates of Yemen. The pattern appears nearly similar to the international figures with a low incidence of MSC.

  10. los soplos cardiacos izquierdos: controversia entre los aspectos clinicos y los ecocardiograficos

    OpenAIRE

    Castaño Valencia, Oscar

    2009-01-01

     By the fact always it has been a cardiologist clinical vocation and have had the privilege of meeting many of the technological advances that currently handle such as hemodynamics, angiography, computed tomography and echocardiography type M, two-dimensional with doppler color, I have had the opportunity to appreciate the contributions of these techniques in the diagnosis of mitral stenosis, mitral insufficiency, aortic stenosis and aortic regurgitation for example. However, I think the Gene...

  11. Myositis ossificans progressiva: A clinico-radiological evaluation-Case report with brief review of literature

    Directory of Open Access Journals (Sweden)

    Nikhil Rathee

    2016-01-01

    Full Text Available Myositis ossificans progressiva/fibrodysplasia ossificans progressiva (MOP, is an autosomal dominant mesodermal tissue disorder, characterized by an initial period of inflammation and subsequent proliferation of fibrous tissue with the formation of ectopic bone tissue. The incidence of MOP is one case per two million people. The ectopic bone tissue formed is located in soft tissue mainly in the connective tissue of striated musculature. We report MOP in an 18-year old female who presented with multiple tender, hard swelling in various parts of the body associated with stiffness and limitations of movements. A literature review of the subject showed few similar case reports in the literature. We revisit the criteria for diagnosis and the essentials of management and treatment of MOP as it is rare being a rare condition, and treatment guidelines are not clear.

  12. The clinico-anatomic explanation for tibial intraneural ganglion cysts arising from the superior tibiofibular joint

    Energy Technology Data Exchange (ETDEWEB)

    Spinner, Robert J. [Mayo Clinic, Department of Neurologic Surgery, Rochester, Minnesota (United States); Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota (United States); Mayo Clinic, Department of Anatomy, Rochester, Minnesota (United States); Mokhtarzadeh, Ali; Schiefer, Terry K. [Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Krishnan, Kartik G. [Carl Gustav Carus University Hospital, Department of Neurological Surgery, Dresden (Germany); Kliot, Michel [University of Washington, Department of Neurosurgery, Seattle, Washington (United States); Amrami, Kimberly K. [Mayo Clinic, Department of Radiology, Rochester, Minnesota (United States)

    2007-04-15

    To demonstrate that tibial intraneural ganglia in the popliteal fossa are derived from the posterior portion of the superior tibiofibular joint, in a mechanism similar to that of peroneal intraneural ganglia, which have recently been shown to arise from the anterior portion of the same joint. Retrospective clinical study and prospective anatomic study. The clinical records and MRI findings of three patients with tibial intraneural ganglion cysts were analyzed and compared with those of one patient with a tibial extraneural ganglion cyst and one volunteer. Seven cadaveric limbs were dissected to define the articular anatomy of the posterior aspect of the superior tibiofibular joint. The condition of the three patients with intraneural ganglia recurred because their joint connections were not identified initially. In two patients there was no cyst recurrence when the joint connection was treated at revision surgery; the third patient did not wish to undergo additional surgery. The one patient with an extraneural ganglion had the joint connection identified at initial assessment and had successful surgery addressing the cyst and the joint connection. Retrospective evaluation of the tibial intraneural ganglion cysts revealed stereotypic features, which allowed their accurate diagnosis and distinction from extraneural cases. The intraneural cysts had tubular (rather than globular) appearances. They derived from the postero-inferior portion of the superior tibiofibular joint and followed the expected course of the articular branch on the posterior surface of the popliteus muscle. The cysts then extended intra-epineurially into the parent tibial nerves, where they contained displaced nerve fascicles. The extraneural cyst extrinsically compressed the tibial nerve but did not directly involve it. All cadaveric specimens demonstrated a small single articular branch, which derived from the tibial nerve to the popliteus. The branch coursed obliquely across the posterior surface of the popliteus muscle before innervating the postero-inferior aspect of the superior tibiofibular joint. The clinical, MRI and anatomic features of tibial intraneural ganglion cysts are the posterior counterpart of the peroneal intraneural ganglion cysts arising from the anterior portion of the superior tibiofibular joint. These predictable features can be exploited and have implications for the pathogenesis of these intraneural cysts and treatment outcomes. These ganglion cysts are joint-related and provide further evidence to support the unifying articular theory. In each case the joint connection needs to be identified preoperatively, and the articular branches and the superior tibiofibular joint should be addressed operatively to prevent cyst recurrence. (orig.)

  13. Clinico-microbiological study of dermatophytosis in a tertiary-care hospital in North Karnataka

    Directory of Open Access Journals (Sweden)

    Tonita M Noronha

    2016-01-01

    Full Text Available Context: The dermatophytoses constitute a group of superficial fungal infections of keratinized tissues, namely, the epidermis, hair, and nails. The distribution and frequency of dermatophytosis and their etiologic agents vary according to the geographic region studied, the socio-economic level of the population, the time of study, the climatic variations, the presence of domestic animals, and age. Aims: The present study was undertaken to assess the clinical profile of dermatophytic infections and to identify the causative fungal species in the various clinical presentations. Settings and Design: This was a hospital-based observational study. Materials and Methods: One hundred and fifty clinically suspected cases of dermatophytosis attending the outpatient department of a tertiary care hospital were included in the study. History was taken, general physical and cutaneous examination was done and details of skin lesions noted. Direct microscopy in 10% KOH (40% KOH for nail and fungal culture on SDA with 0.05% chloramphenicol and 0.5% cycloheximide was done in every case. Statistical Analysis Used: Statistical analysis was done using SPSS 17.0 software. Chi-square test and contingency coefficient test were used as significant tests for analysis. Results: Out of 150 patients studied, majority belonged to the age group of 21–30 years (22.7%. Male-to-female ratio was 1.63:1. Tinea corporis (24.7% was the most common clinical type observed. The overall positivity by culture was 40% and by direct microscopy was 59.3%. Trichophyton mentagrophytes was the predominant species isolated (48.3%. Conclusions: The present study reveals the changing trend in the prevalence of dermatophyte species in this part of Karnataka.

  14. Clinico-radiographic Studies on The Prevalent Distal Limb Affections in Working Equine at Luxor City

    Directory of Open Access Journals (Sweden)

    A. A.A. Abdel-Hady

    2017-01-01

    Full Text Available To illustrate the clinical and radiographic findings of some distal limbs affections in Ninety two animals (24 horses and 68 donkeys which were admitted to Animal Care Hospital in Luxor. Each animal was subjected to thorough clinical and radiographic examination; the grade of lameness was recorded and the best radiographic views were taken.  Fifteen types of distal limb affections were evident. The most prevalent affections in donkeys were high and low ring bone (29.35% and hoof abscess ( 9.78% followed by traumatic arthritis of the fetlock (6.52%, suspensory ligament desmitis (5.43%, fracture of first phalanx (5.43%, fracture of PII (4.35%, side bone (3.26%  whereas, fracture of metacarpal bone (1.09%, sesamoditis (1.09% and flexural deformities (1.09%  represented the lowest prevalent affections.On the other hand, side bone (4.35%, fracture of the metacarpal bone (4.35% represented the most prevalent affections in horses followed by high and low ring bone (3.26%, fractures of PI (2.17%, PII (2.17%, subluxation of coronopedal joint (2.17% and punctured wounds in of the hoof (2.17%, traumatic arthritis of the fetlock joint (2.17%. Whereas, navicular disease (1.09%, suspensory ligament desmitis (1.09% and hoof abscess (1.09% were the lowest prevalent affections in horses. Treatment was not recommended in certain cases. In conclusion, although the wide stride progress have made in diagnostic imaging in recent decades, the x ray still offers a satisfactory tool for diagnostic imaging in equine limb practice that is useful for equine practitioners.

  15. CLINICO-MORPHOLOGICAL RESEARCH OF BIO-OSS ® DURING BONE-PLASTIC OPERATIONS

    Directory of Open Access Journals (Sweden)

    Pavel SIDELNIKOV

    2016-03-01

    Full Text Available Aim: To study the clinical and morphological characteristics of Bio-Oss ® and Bio-Gate ® materials during bone-plastic operations, especially bone regeneration after surgical interventiond. Materials and method: The pathomorphological study was performed with the intravital biopsy material of bone tissue from augmentation areas, obtained during implants placement. Clinical studies included subjective and objective methods, in particular X-ray analysis and photo documenting. Bio-Oss ®, Bio-Gide ®, Bio-Gide ® Perio membranes, Resor-Pin pins, U-impl implant systems were investigated and 231 operations were performed with Bio-Oss ® and Bio-Gate ®, of which 38 cases of sinus lifting, 145 of bone plasty with simultaneous implantation and 48 cases of periodontal surgery. Results: Usage of bone-plastic Bio-OSS ® and Bio-Gate ® materials during various bone-plastic and periodontal operations assures a high clinical effect (from 93 to 99%. Morphologically, it has been observed that, after usage of bone Bio-OSS ® and Bio-Gate ® materials, a new osteoid tissue was formed, similar to the bone tissue of the alveolar process, with high mineralization levels, especially in the first 2 years, due to the simultaneous resorption of the material. The newly-formed tissue has a classical design and can fully perform the functions of jaw bones, especially for carrying loads transmitted with either teeth or implants.

  16. Clinico-pathological factors influencing surgical outcome in drug resistant epilepsy secondary to mesial temporal sclerosis.

    Science.gov (United States)

    Savitr Sastri, B V; Arivazhagan, A; Sinha, Sanjib; Mahadevan, Anita; Bharath, R D; Saini, J; Jamuna, R; Kumar, J Keshav; Rao, S L; Chandramouli, B A; Shankar, S K; Satishchandra, P

    2014-05-15

    Mesial temporal sclerosis (MTS) is the most common cause of drug resistant epilepsy amenable for surgical treatment and seizure control. This study analyzed the outcome of patients with MTS following anterior temporal lobectomy and amygdalohippocampectomy (ATL-AH) over 10 years and correlated the electrophysiological and radiological factors with the post operative seizure outcome. Eighty seven patients were included in the study. Sixty seven (77.2%) patients had an Engel Class 1 outcome, 9 (11.4%) had Class 2 outcome. Engel's class 1 outcome was achieved in 89.9% at 1 year, while it reduced slightly to 81.9% at 2 years and 76.2% at 5 year follow up. Seventy seven (88.5%) patients had evidence of hippocampal sclerosis on histopathology. Dual pathology was observed in 19 of 77 specimens with hippocampal sclerosis, but did not influence the outcome. Factors associated with an unfavorable outcome included male gender (p=0.04), and a higher frequency of pre-operative seizures (p=0.005), whereas the presence of febrile seizures (p=0.048) and loss of hippocampal neurons in CA4 region on histopathology (p=0.040) were associated with favorable outcome. The effect of CA4 loss on outcome is probably influenced by neuronal loss in other subfields as well since isolated CA4 loss was rare. Abnormal post operative EEG at the end of 1 week was found to be a significant factor predicting unfavorable outcome (p=0.005). On multivariate analysis, the pre-operative seizure frequency was the only significant factor affecting outcome. The present study observed excellent seizure free outcome in a carefully selected cohort of patients with MTS with refractory epilepsy. The presence of dual pathology did not influence the outcome. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. A clinico-radiologic study of bony remodeling of the fractured condyles in children

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jeong Shin; Park, Chang Seo [Department of Dentistry, The Graduate School, Yonsei University, Seoul (Korea, Republic of)

    1995-08-15

    Bony remodeling pattern of condyle fractures in children are different from in adult for growing of condyle, also might affect treatment and prognosis of the condyle fracture. Subjects of this clinical and radiologic study were 26 temporomandibular joints diagnosed as condyle fracture in 23 patients under 15 years old age, They were treated with conservative method at Dental Hospital of Yonsei University from Jan., 1986 to Oct., 1994. Bony remodeling related with fracture pattern was evaluated. The results obtained are as follows: 1. The ratio of male to female in patients with condyle fracture was 1 : 0.9 and the difference of sex ratio was not noted. Comparing with preschool-age group and school-age group, age frequency was higher in preschool-age group (83%). 2. Fallen down (54%) was the most frequent cause of condyle fractures. Traffic accident and slip down were followed. 3. The most common clinical sign of condyle fractures was tenderness to palpation (19 cases). Mouth opening limitation (17 cases), swelling (7 cases), malocclusion (3 cases) were next in order. 4. According to sites of condyle fractures, unilateral fractures were in 20 patients and bilateral fractures in 3 patients, therefore total 23 patients-26 cases of condyle fracture were observed. According to fracture distribution, condyle fractures were in 10 patients (44%). Condyle fractures with symphysis fracture (9 patients, 39%), condyle fractures with ascending ramus fracture (2 patients, 9%), condyle fracture with mandibular body fracture (1 patient, 4%), and condyle fractures with mandibular angle fracture (1 patient, 4%) were followed. 5. In displacement pattern of fractured fragment of mandibular condyle, displacement (17 cases, 66%) was most common. Dislocation (5 cases, 19%) and deviation (4 cases, 15%) were next in order. 6. During the observation period of fractured condyles, remodeling patterns of fracture sites related with articular fossa were observed with usual congealer shape in 23 cases and with prominently different shape in 3 cases.

  18. Fetal MR Imaging Analysis of Sirenomelia with Clinico Radiographic Correlation: A Case Report.

    Science.gov (United States)

    Nori, Madhavi; Prasad, Raghavendra G; Reddy, Arvind K; Cheguri, Sandeep Reddy

    2016-06-01

    Sirenomelia is a social curiosity, a medical and diagnostic challenge prenatally compounded by varied diagnostic difficulties. Prenatal diagnosis of sirenomelia was and continues to be a challenge although von klippel et al., described a case at 10 weeks of gestational age. However, they needed a second imaging at 12(th) week for confirmation. First trimester or early second trimester anatomic survey on ultrasound and MRI is accurate for the diagnosis thereby avoiding unnecessary complex pregnancy. We report a case of second trimester diagnosed sirenomelia, with detailed analysis of image findings on ultrasound and fetal MRI.

  19. Association between severity of depression and clinico-biochemical markers of polycystic ovary syndrome.

    Science.gov (United States)

    Enjezab, Behnaz; Eftekhar, Maryam; Ghadiri-Anari, Akram

    2017-11-01

    Polycystic ovary syndrome (PCOS), as the most common endocrine disorder among reproductive-aged women may lead to psychological morbidity. The present study set out to evaluate the severity of depression in PCOS and non-PCOS women and to evaluate correlation between depression score with body mass index, HOMA-IR, and testosterone level in every group (PCOS and non-PCOS women) in Yazd province. In this cross-sectional study, 62 women with PCOS and 61 non- PCOS subjects (20 to 40 years) who were attending Imam-Ali Clinic in Yazd, Iran from September 2014 through March 2015 participated. These persons completed the Beck Depression Short Inventory (BDI-S) Questionnaire. Frequency of depression in PCOD and healthy persons and correlation between depression severity with body mass index, HOMA-IR, testosterone level in PCOS and non- PCOS women were evaluated by ANOVA test and independent-samples t-test and Pearson correlation. P-value of less than 0.05 was considered as statistically significant. Data analyses were performed using SPSS version 16. Of 62 PCOS subjects, 40 (64.5%) were verified positive for depression, determined by the BDI-S Questionnaire. In the control group, 60.7% had depression. Mean±SE score of depression for PCOS and non-PCOS women were 7.47±5.54 and 7.57±5.77 respectively. There was no statistically significant correlation between body mass index, HOMA-IR, testosterone level with depression score in either group separately or together. We found considerable amounts of depression in our population. There is no correlation between body mass index, HOMA-IR, and testosterone level with depression score in our study.

  20. [The hypothalamic syndrome in childhood (its epidemiological and clinico-electrophysiological aspects)].

    Science.gov (United States)

    Solov'eva, A D; Vorob'eva, O V; Loseva, M M; Khaspekova, N B; Fedorova, V I; Musaeva, Z A; Filatova, E G

    1994-01-01

    The epidemiological survey covered 2000 city schoolchildren. They ranged in age from 7 to 15 years. Hypothalamic deficiency (HD) was detected in 5% of the examinees. Clinical and physiological findings on HD children are provided. They were found to have the history of hereditary or natal damage evidencing the acquired nature of the disease. Special emphasis is placed on HD manifestations in prepubertal and pubertal age. The authors show defective regulation of nonspecific brain systems in the form of predominant activation of the septohippocampal system and relative insufficiency of the brain stem mesencephalic reticular formation. Activation of cerebral ergotropic vegetative mechanisms combines with peripheral vegetative failure (sympathetic and parasympathetic), probably, of congenital origin.

  1. FRACASO RENAL AGUDO EN EL PACIENTE ONCOLOGICO. ANALISIS CLINICO Y PRONOSTICO.

    Directory of Open Access Journals (Sweden)

    Purroy A,

    2004-01-01

    Full Text Available RESUMEN: El fracaso renal agudo es un problema frecuente en el paciente oncológico, que plantea limitaciones en el pronóstico y en el planteamiento terapeútico. El desarrollo de registros de pacientes oncológicos con fracaso renal agudo permite analizar el perfil clínico y plantear aspectos a desarrollar desde el punto de vista terapeútico y sobre todo preventivo. El empleo de determinados índices pronósticos como el ISI (Liaño o el de fallo multiorgánico permite evaluar mejor este perfil clínico. En nuestra experiencia el fracaso renal agudo en el paciente oncológico es una complicación frecuente y relacionada con el proceso de base. Mediante este registro de pacientes hemos identificado un perfil clínico de alto riesgo consistente en un paciente con un fallo renal asociado a un proceso infeccioso, con insuficiencia respiratoria, oligúrico y con una puntuación elevada de esos índices pronósticos.

  2. A Clinico-Epidemiological Study on Poisonings due to Cardiovascular Drugs in Ahvaz, Iran

    Directory of Open Access Journals (Sweden)

    Marzie Zeinvand

    2017-03-01

    Full Text Available Background: Overdoses with cardiovascular drugs are related with significant morbidity and mortality. Beta-adrenergic blockers, calcium-channel blockers (CCBs, thiazide, digoxin and angiotensin converting enzyme (ACE inhibitors represent five of the most important classes of cardiovascular drugs. Overdoses with cardiovascular drugs are typically caused by exploratory ingestion by children or intentional ingestion by suicidal adults. As no study has been performed about poisoning with this kind of drug in Khuzestan, this study aimed to investigate the frequency of cardiovascular drug poisoning and its clinical features in patients presenting in Razi Hospital of Ahvaz from 2005 to 2009. Methods: A retrospective review of medical records of patients poisoned with cardiovascular who were treated at Clinical Toxicology Department was executed. A total of 70 poisoning cases referred to Razi Hospital were identified. These unselected cases included intentional, accidental, criminal and occupational circumstances. Beta-blocker poisoning, digital poisoning, calcium-channel blockers poisoning, ACE inhibitor poisoning, thiazide poisoning and poisoning with other cardiovascular drugs were evaluated on the basis of recorded data. Poisoning with one or several agents, time of admission, type of poisoned agents, sex, age, therapeutic intervention and mortality were investigated. Results: This study revealed that most of the people poisoned with cardiovascular drugs were females, single people and urban population. Most of the patients were 15-25 years old. Most poisoning was with beta blocker and calcium channel blockers. Their first symptom was headache and most of them needed ICU admission. Most of the patient ECGs were normal. There were 2 cases of death. Conclusion: This study revealed that continuous health care and the administration of the exact dose of drugs in the appropriate time and also developing of the toxicology centers seem necessary.

  3. Insights into thermoregulation: A clinico-radiological description of Shapiro syndrome.

    LENUS (Irish Health Repository)

    Pazderska, Agnieszka

    2013-06-15

    Shapiro syndrome is a rare entity, comprising a triad of recurrent hypothermia, hyperhidrosis and congenital agenesis of the corpus callosum. Fewer than 50 cases have been described, almost invariably in patients presenting in childhood or early adulthood. We present a case of an 80year old woman presenting with recurrent bouts of shivering, sweating and profound malaise, who sought medical attention because the frequency and severity of attacks worsened in her later years. MRI Brain demonstrated agenesis of the corpus callosum; a rigorous work-up excluded other causes for her symptomatology. The intricate interplay of neuronal networks involved in thermoregulation remains to be fully elucidated and as such, little is known about the pathophysiological mechanisms underlying the clinical manifestations of Shapiro syndrome. We present novel data from FDG-PET imaging of our patient, demonstrating hypermetabolism in a number of brainstem and cerebellar regions during the symptomatic phase. These findings imply that aberrant thermoregulation in Shapiro syndrome involves a number of structures remote from the callosal region. We also present neuropsychometric findings in our patient, of which there have been no reports to date. We postulate that the ageing brain may be more susceptible to the paroxysmal neurochemical fluxes implicated in the syndrome.

  4. Clinico-pathology of lung cancer in a regional cancer center in Northeastern India.

    Science.gov (United States)

    Mandal, Sanjeet Kumar; Singh, Thaudem Tomcha; Sharma, Takhenchangbam Dhaneshor; Amrithalingam, Venkatesan

    2013-01-01

    Globally, there have been important changes in trends amongst gender, histology and smoking patterns of lung cancer cases. This retrospective study was conducted on 466 patients with lung cancer who were registered in Regional Cancer Center, Regional Institute of Medical Sciences, Manipur from January 2008 to December 2012. Most were more than 60 years of age (67.8%) with a male: female ratio of 1.09:1. Some 78.8% of patients were chronic smokers with male smoker to female smoker ratio of 1.43:1. Consumption of alcohol was found in 29.4%, both smoking and alcohol in 27.5%, betel nut chewing in 37.9% and tobacco chewing in 25.3%. A history of tuberculosis was present in 16.3% of patients. The most frequent symptom was coughing (36.6%) and most common radiological presentation was a mass lesion (70%). Most of the patients had primary lung cancer in the right lung (60.3%). The most common histological subtype was squamous cell carcinoma (49.1%), also in the 40-60 year age group (45.9%), more than 60 year age group (51.6%), males (58.1%) and females (41.8%). As many as 91.9% of squamous cell carcinoma patients had a history of smoking. About 32.5% of patients had distant metastasis at presentation with brain (23.8%) and positive malignant cells in pleural effusions (23.1%) as common sites. The majority of patients were in stage III (34.4%), stage IV (32.5%) and stage II (30.2%). Our analysis suggests that the gender gap has been narrowed such that about half of the patients diagnosed with lung cancer are women in this part of India. This alarming rise in female incidence is mainly attributed to an increased smoking pattern. Squamous cell carcinoma still remains the commonest histological subtype. Most of the patients were elderly aged and presented at locally or distantly advanced stages.

  5. CLINICO-MICROBIOLOGICAL STUDY OF TOXOPLASMOSIS IN PREGNANT FEMALES WITH BAD OBSTETRIC HISTORY (BOH

    Directory of Open Access Journals (Sweden)

    Neha Singh

    2017-09-01

    Full Text Available BACKGROUND Context- Toxoplasmosis is an infection caused by a microscopic parasite called Toxoplasma gondii. Although, the infection generally causes a mild symptomless illness in people with healthy immune systems, it is of risk during pregnancy as it can infect the growing foetus in utero. The aim of the study is to assess the seroprevalence of IgG and IgM antibodies for toxoplasmosis in women with normal pregnancy, pregnant women with one abortion and pregnant women with two or more abortions (BOH. The seropositivity was analysed according to number of abortions, age, parity and trimester of pregnancy. MATERIALS AND METHODS Serum samples were collected from pregnant women attending antenatal clinic with demographic data. Patients were divided into three groups- Normal pregnant women without any history of abortion (N, pregnant patients with one abortion (A1 and those with two or more abortions (A2 that is those with a Bad Obstetric History (BOH. 83 serum samples were subjected for determination of toxoplasma IgM antibodies and 81 for toxoplasma IgG antibodies. The study was carried out over a period of two years from November 2012 to October 2014. Settings and Design- Experimental and analytical study. RESULTS Toxoplasma IgM prevalence was 1.2% and that of IgG was 27.16%. The distribution showed increase of IgG and IgM with increase in the number of abortions. In normal group patients (N, IgG was mostly positive for patients with gestational age 2nd trimester (13-28 weeks. The distribution also showed that in this group IgG was positive for those in the age group of 20- 25 years. In group, A1 patients IgG was equally positive for those with gestational age 2nd trimester (13-28 weeks and 3rd trimester (29-40 weeks. In this group, IgG was mostly positive for those in the age group of 20-25 years and 26-30 years, respectively. The distribution for group A2 patients showed an increase of IgG antibodies for those with gestational age 1st trimester (1-12 weeks. The patients of this group also showed increased IgG antibodies in the age group 20-25 years and 26- 30 years. CONCLUSION High prevalence of toxoplasma IgG antibodies indicates previous exposure or asymptomatic infection. There was only one case of IgM antibody and the patient belonged to group A2, which is highly suggestive of BOH due to toxoplasmosis. The prevalence of toxoplasma in the community could be because of non-vegetarian food habits of the patients or consumption of contaminated food and vegetables. Early detection of toxoplasmosis in pregnant women can reduce severity of the disease in the newborn.

  6. Angiogenesis in non-Hodgkin's lymphoma: clinico-pathological correlations and prognostic significance in specific subtypes

    DEFF Research Database (Denmark)

    Jørgensen, Judit Meszaros; Sørensen, Flemming Brandt; Bendix, K

    2007-01-01

    The aim of the study was to evaluate angiogenesis in different subtypes of non-Hodgkin's lymphoma (NHL) and to correlate angiogenic scores to clinical endpoints. Pre-therapeutic lymph node biopsies from 308 patients with NHL [107 follicular B-cell lymphoma (FL), 94 diffuse large B-cell lymphoma (...

  7. Intraductal papillary mucinous neoplasm of the pancreas (IPMN: clinico-pathological correlations and surgical indications

    Directory of Open Access Journals (Sweden)

    Cantù Massimiliano

    2010-04-01

    Full Text Available Abstract Background Intraductal papillary mucinous neoplasms (IPMNs are increasingly recognized entities, whose management remains sometimes controversial, due to the high rate of benign lesions and on the other side to the good survival after resection of malignant ones. Methods Retrospective analysis of a prospectively collected Western series of IPMN. Results Forty cases of IPMN were analysed (1992-2007. Most patients were symptomatic (72.5%; cholangio-MRI had the best diagnostic accuracy both for the tumour nature (83.3% and for the presence of malignancy (57.1%. ERCP was done in 8 cases (20%, and the results were poor. Thirteen patients were treated by pancreatic resection and 27 were maintained in follow-up. Total pancreatectomy was performed in 46% of the cases; in situ and invasive carcinoma were recognized in 15.4% and 38.4% of the cases, respectively. The mean follow-up was 42 months (range 12-72. One only patients with nodal metastases died 16 months after the operation for disease progression, while 91.6% of the operated patients are disease free. Out of the 27 not resected patients, 2 out of 4 presenting a lesion at high risk for malignancy died, while the remaining are in good conditions and disease free, with a mean follow-up of 31 months. Conclusion Therapeutic indication for IPMNs is mainly based upon radiological evaluation of the risk of malignancy. While the main duct tumours should be resected, preserving whenever possible a portion of the gland, the secondary ducts tumours may be maintained under observation, in absence of radiological elements of suspicion such as size larger than 3 cm, or a wall greater than 3 mm or nodules or papillae in the context of the cyst.

  8. CLINICO PATHOLOGICAL STUDY OF BENIGN BREAST LUMP – A HOSPITAL BASED STUDY

    Directory of Open Access Journals (Sweden)

    Anindita

    2016-03-01

    Full Text Available BACKGROUND Despite the fact that in majority of cases the initial symptom of benign breast disease is a lump, which can be easily detected by the patient herself by self-examination they generally present at a very late stage and this poses a great difficulty in their management. Early and appropriate diagnosis of breast disease is of utmost importance. AIM The aim of the study was to find out the relative frequency and commonest site of occurrence of benign breast disorder and their relationship with age, parity, menstrual cycle, and socio-economic status and also to find out the accuracy of investigative procedures in their diagnosis. DESIGN This is a cross sectional, interventional. Hospital based study. MATERIALS AND METHOD This study was done in 58 female patients in the age group 10 yrs. to 55 yrs. presenting with clinically benign breast lumps randomly chosen from outpatient department and indoor wards of The Calcutta Medical Research Institute, Kolkata. After taking an accurate history and proper clinical examination these patients were sequentially studied by radiological methods (Ultrasonography and mammography, fine needle aspiration cytology (FNAC and histopathology of removed specimen. Patients were enquired about their age, chief complaints, menstrual history, and use of oral pill, marital status, parity, lactation and socioeconomic status. RESULTS 79% of the benign breast lumps were found to be between 10–35 years, Fibro adenoma being the commonest one (41.38% and fibrocystic disease the second most common (29.31%. Breast lump were more common among unmarried and nulliparous females (48.27%, commonest site being upper and outer quadrant (38.8%. 69% patients were associated with an abnormal menstrual status. 76% of the cases were accurately diagnosed by clinical examination, 70% by mammography, 88% by FNAC and 84% by ultrasonography. CONCLUSION This clinicopathological study of benign breast lump is a small endeavour on our part to suggest that correct interpretation of clinical, radiological, cytological and histopathological findings will help for accurate diagnosis of benign breast lumps.

  9. Clinico-pathologic spectrum of accessory axillary breast; case series and literature review

    Directory of Open Access Journals (Sweden)

    Usman Bello

    2017-01-01

    Full Text Available Accessory breast and the diseases affecting these aberrant breast tissues are relatively uncommon, and with variable prevalence among different populations. These are commonly located in the axilla, chest wall, and vulva. The most common disease in these tissues is carcinoma; however, other benign neoplastic and nonneoplastic lesions do occur. In this review, we present a clinicopathologic analysis of all the consecutive cases seen in a major referral teaching hospital over a period spanning 10 years (2006–2015.

  10. Chronic gastritis with intestinal metaplasia: clinico-statistical, histological and immunohistochemical study.

    Science.gov (United States)

    Dîrnu, Rodica; Secureanu, F A; Neamţu, Carmen; Totolici, B D; Pop, O T; Mitruţ, P; Mălăescu, D Gh; Mogoantă, L

    2012-01-01

    Chronic gastritis has a high incidence in adults, causing progressive destruction of glandular structures, favoring the development of gastric atrophy. The association of chronic gastritis with intestinal type metaplasia of gastric mucosa has a poor outcome as intestinal metaplasia is regarded as a precancerous lesion. Metaplasia is common in patients with Helicobacter pylori infection and also heavy smokers. The aim of our study was to evaluate the relationship between chronic gastritis and intestinal metaplasia. The study was conducted on a total of 1218 patients, aged between 5 and 90 years, who presented for dyspeptic disorders in the period 2007-2010 and were examined clinically and endoscopically. During the gastroscopic examination, fragments of gastric mucosa were collected for the histopathological study and for highlighting the H. pylori infection. For the histopathological study, the Hematoxylin-Eosin and PAS-Alcian Blue stains were performed, while for the immunohistochemical study the anti-TAG72 and anti-PCNA antibodies were used. A diagnosis of gastritis was established in 615 patients, representing approximately 50.5% of all cases. Most cases with gastritis were found in people of middle age. Gastritis was present in almost all age groups, from teenagers to the elders. Of the 615 cases of gastritis, urease test was positive in 353 patients, representing approximately 57.40% of all patients with gastritis. Histopathological examination identified the presence of intestinal metaplasia in 61.60% of patients with chronic gastritis, mostly complete metaplasia. PCNA immunohistochemistry revealed that cell proliferation processes are intensified in intestinal metaplasia. This study highlights the importance of chronic gastritis, intestinal metaplasia, and H. pylori infection in the etiopathogeny of gastric cancer.

  11. Clinico-morphological features of the female genital tract: review of the literature

    Directory of Open Access Journals (Sweden)

    S. O. Nikogosyan

    2012-01-01

    Full Text Available In the review are provided data of the world literature on clinical and morphological features of neuroendocrine tumors of the female sexual sphere. Questions of pathogenesis and stages of development of new growths in embryogenesis considered. Historical references are given. Besides, in article questions of diagnostics and treatment of these tumors are taken up.

  12. Lingual and fusiform gyri in visual processing: a clinico-pathologic study of superior altitudinal hemianopia.

    OpenAIRE

    Bogousslavsky, J; Miklossy, J; Deruaz, J P; Assal, G; Regli, F

    1987-01-01

    A macular-sparing superior altitudinal hemianopia with no visuo-psychic disturbance, except impaired visual learning, was associated with bilateral ischaemic necrosis of the lingual gyrus and only partial involvement of the fusiform gyrus on the left side. It is suggested that bilateral destruction of the lingual gyrus alone is not sufficient to affect complex visual processing. The fusiform gyrus probably has a critical role in colour integration, visuo-spatial processing, facial recognition...

  13. Clinico-pathological investigation of resectable gastric cancer in atomic bomb survivors

    International Nuclear Information System (INIS)

    Tanaka, Takashi; Saeki, Toshiaki; Hirai, Toshihiro; Toge, Tetuya; Niimoto, Minoru; Hattori, Takao; Ootaki, Megu; Munaka, Masaki

    1989-01-01

    This is a review of 1074 patients with resectable gastric cancer who have satisfied the following criteria: primary cancer, histological confirmation, the description of exposed or non-exposed patients, and certification of atomic bomb survivor's health handbook in exposed patients. There were 250 men and 162 women in the exposed group, and 460 men and 203 women in the non-exposed group. Gastric cancer was detected in 29.6% for the exposed group and 7.4% for the non-exposed group, although the patients had not complained of any symptoms. These figures tended to increase annually, probably benefiting from health examination. The difference between the exposed and non-exposed patients tended to be smaller when preoperative stages and the percentage of macroscopic early cancer were adjusted by age and the presence of complaints. The difference in histology between the groups also tended to be smaller. In the exposed group, however, men and women tended to have well differentiated cancer and poorly differentiated cancer, respectively. Since A-bomb survivors consist of radiation exposed population and are managed under intensive medical care, adjustment of some factors is necessary in comparing A-bomb survivors with general population. (Namekawa, K)

  14. Clinico-radiologic considerations of middle ear fractures and its complications, about eight cases

    International Nuclear Information System (INIS)

    Mauricio, J.C.; Medina, E.; Goulao, A.; Monteiro, S.

    1985-01-01

    Eight cases of middle ear fractures are studied. The fracture deslocation of the ossicula, the lesions of facial canal and the meningocerebral complications associated with continuity solution of the 'tegmens' were characterized by computed tomography (CT - 'target program'). The CT with cisternography using contrast media hydrosoluble is also a method to determinate the place of the otoliquorrhea. The conclusion is that the CT image reconstruction by algorithms that has high powers of resolution and contrast are today indispensable to diagnosis and surgical planement of the deafness, facial palsy and tympanic hernia of the brain and arachnoidea cisterns. (Author) [pt

  15. Clinico-epidemiological study of congenital ichthyosis in a tertiary care center of Eastern India

    Directory of Open Access Journals (Sweden)

    Arghyaprasun Ghosh

    2017-01-01

    Full Text Available Background: Congenital ichthyoses comprises various specific genetic diseases and can range from mild to very severe presentation. Furthermore, these may be associated with various syndromes. There is scanty data regarding the demographic profile and clinical features of patients with congenital ichthyosis in India. Aims and Objectives: The aim is to evaluate the epidemiology and clinical characteristics of various types of congenital ichthyoses. Materials and Methods: The study was conducted for 1 year from April 2013 to March 2014. Patients were evaluated for epidemiological profile and clinical features. Results: During the study of 1 year, 106 patients of congenital ichthyoses were identified. The most common of the various ichthyoses was ichthyosis vulgaris, followed by lamellar ichthyosis, X-linked recessive ichthyosis. One case of Netherton syndrome and one of ichthyosis hystrix were also identified. Conclusion: Various types of congenital ichthyoses present with different clinical features which range from mild to severe. These present with significant psychological stress to both patients and their families. Furthermore, all these diseases have significant implications of transmission to their offspring.

  16. A study of clinico-demographic profile of patients with dissociative disorder

    Directory of Open Access Journals (Sweden)

    SK Shah

    2013-09-01

    Full Text Available Objectives To study the clinical and socio demographic profile of patients with dissociative disorder and their comorbid mental illness. Materials and methods Fifty-one patients of dissociative disorder presenting to emergency and outpatient department of Psychiatry at College of Medical Sciences Teaching Hospital during the period from Jan to March 2012 were included. International statistical classification of diseases and related health problems tenth edition, diagnostic criteria for research (ICD-10, DCR was used. Results Out of 51 patients, the majority 24 (47.1%, were in the age group 15-29. However the age of presentation ranged from 9-45 years. The females were more, 44 (86.3% as compared to males 7 (13.7%. The majority of patients had low level of education with none of the patients having education above intermediate level. The majority of patients, 27(52.9% belonged to lower middle class. 49% of the patients presented with dissociative convulsions, 15.7% with dissociative motor disorders, 15.7% with dissociative stupor, 11.8% with dissociative anesthesia and sensory loss and 7.8% with trance and possession disorder. Depressive illness was found co-morbid with dissociative disorder in 33.3%, borderline personality disorder in 9.8% and histrionic personality disorder in 7.8%. There was history of immediate stressful events that supposedly precipitated the event in 76.5%. Conclusion Dissociative disorder mainly affects young female of lower socio-economic and educational status with history of immediate stressful life events precipitating the illness. Journal of College of Medical Sciences-Nepal, 2012, Vol-8, No-3, 30-35 DOI: http://dx.doi.org/10.3126/jcmsn.v8i3.8683

  17. A Study of Insulin Resistance and its Clinico.Metabolic Associations ...

    African Journals Online (AJOL)

    HOMA]-IR). Results: The mean IR was 1.5 (1.0). Individuals with MS, higher body mass index and CRP ≥6 mg/l had higher IR. Linear regression showed, among the components of MS, waist circumference had the highest contribution toward ...

  18. Reporte de caso Adenocarcinoma de celulas basales de glandula parotida: estudio clinico/patologico e inmunohistoquimico

    Directory of Open Access Journals (Sweden)

    Pedro Emilio García

    Full Text Available Resumen: El adenocarcinoma de células basales es una neoplasia epitelial con las características citológicas del adenoma de células basales pero con un patrón morfológico de crecimiento infiltrante indicativo de malignidad. Debido a su baja incidencia es a menudo difícil de diagnosticar. El objetivo del presente estudio fue identificar características morfológicas e inmunohistoquímicas que contribuyen a su diagnóstico. Se resecó un tumor de parótida en una paciente de 52 años; se realizó biopsia postoperatoria e inmunomarcación con Ki-67, CK19, p63 y alfa actina de músculo liso. Se diagnosticó adenocarcinoma de células basales mixto sólido y tubular con invasión perineural y de la cápsula tumoral, grasa periglandular y nodos linfoides. La inmunomarcación con Ki-67, CK19, p63 y alfa actina de músculo liso resultó positiva. Posteriormente se diagnosticó una metástasis en seno maxilar. Las características morfológicas, la inmunomarcación Ki-67 positiva y la metástasis le dan el carácter maligno a este tumor, lo que lo diferencia del adenoma de células basales.

  19. Clinico-biochemical studies on acute toxic nephropathy in goats due to uranyl nitrate

    Energy Technology Data Exchange (ETDEWEB)

    Dash, P.K.; Joshi, H.C.

    1989-02-01

    Acute toxic nephropathy was produced in 6 healthy goats by injecting intravenously 1% uranyl nitrate (UN) (15 mg/kg body weight). The early painful clinical signs simulating shock progressed with subnormal temperature, slow-shallow respiration and arrhythmic pulse followed by death due to respiratory failure within 96 to 120 hr. All the affected goats had normocytic normochromic anemia, leucocytosis, neutrophilia with left shift eosinopenia, decreased monocytes and presence of 1-2% reticulocytes in the peripheral blood smears. On blood chemical analysis, a uniform and continuous rise was seen in serum creatinine with a concomitant daily increase of serum urea and uric acid. Simultaneous analysis of urine indicated polyuria leading to oliguria, acidic pH, albuminuria, glycosuria with presence of neutrophils, RBC's, epithelial and fatty casts, increase of triple phosphate, and cystine crystals reflecting acute damage of kidneys in the affected goats.

  20. Clinico-biochemical studies on acute toxic nephropathy in goats due to uranyl nitrate

    International Nuclear Information System (INIS)

    Dash, P.K.; Joshi, H.C.

    1989-01-01

    Acute toxic nephropathy was produced in 6 healthy goats by injecting intravenously 1% uranyl nitrate (UN) (15 mg/kg body weight). The early painful clinical signs simulating shock progressed with subnormal temperature, slow-shallow respiration and arrhythmic pulse followed by death due to respiratory failure within 96 to 120 hr. All the affected goats had normocytic normochromic anemia, leucocytosis, neutrophilia with left shift eosinopenia, decreased monocytes and presence of 1-2% reticulocytes in the peripheral blood smears. On blood chemical analysis, a uniform and continuous rise was seen in serum creatinine with a concomitant daily increase of serum urea and uric acid. Simultaneous analysis of urine indicated polyuria leading to oliguria, acidic pH, albuminuria, glycosuria with presence of neutrophils, RBC's, epithelial and fatty casts, increase of triple phosphate, and cystine crystals reflecting acute damage of kidneys in the affected goats

  1. Base eletronica de dados clinicos e cirurgicos em isquemia cronica de membros inferiores

    Directory of Open Access Journals (Sweden)

    Carlos Seme Nejm Junior

    2013-09-01

    Full Text Available CONTEXTO: Um sistema eletrônico de protocolo seria capaz de armazenar dados clínicos e possibilitar futuras pesquisas, visando a rapidez, eficiência de cruzamentos e análise de tais dados. OBJETIVO: a criar uma base de dados clínicos cirúrgicos em doenças vasculares e, a partir desta, uma base em Isquemia Crônica de Membros Inferiores; b informatizar essa base sob forma de um protocolo eletrônico; c incorporar ao SINPE(c (Sistema Integrado de Protocolos Eletrônicos; d realizar um projeto piloto. MÉTODOS: Criou-se uma base teórica de dados clínicos sobre as doenças vasculares. O protocolo específico foi criado considerando-se as características individuais das doenças causadoras de Isquemia Crônica de Membros Inferiores. Após seu término, essa base eletrônica e informatizada seria incorporada ao SINPE(c. RESULTADOS: O usuário, previamente cadastrado, realizará o cadastro do paciente e selecionará, dentro do protocolo mestre, o protocolo específico em Isquemia Crônica de Membros Inferiores, para acesso aos seus respectivos dados clínicos. Orientado pelas alternativas diretas de preenchimento, o usuário seleciona apenas os dados pertencentes ao seu paciente. Estes podem ser resgatados para pesquisa, mostrando o número de coletas que satisfazem os parâmetros escolhidos e informações estatísticas sobre a mesma. CONCLUSÃO: a a criação da base teórica de dados clínicos e cirúrgicos em doenças vasculares e, a partir desta, em Isquemia Crônica de Membros Inferiores, foi factível; b a informatização da base teórica sob forma de protocolo eletrônico foi exequível; c o protocolo eletrônico mestre e específico poderá ser incorporado ao SINPE(c, d o projeto piloto foi criado com sucesso e testado através do módulo analisador do SINPE(c.

  2. Correlation of CA-125 serum level and clinico-pathological characteristic of patients with endometriosis.

    Science.gov (United States)

    Karimi-Zarchi, Mojgan; Dehshiri-Zadeh, Najmeh; Sekhavat, Leili; Nosouhi, Fahime

    2016-11-01

    Cancer antigen 125 (CA-125) is a glycoprotein biomarker that is used in women with pelvic masses such as endometriosis and maybe is useful in practice of patients suspicious to endometriosis. The aim of this study was to evaluate the association between preoperative serum CA-125 levels and clinic pathological characteristic in women with endometriosis, and find out the best serum CA-125 levels cut-off in pre and post menopause women. Serum CA-125 levels in 87 women aged 21-54 years suspected to endometriosis with pelvic pain, dysmenorrhea, or dyspareunia were measured preoperatively. Also the association between clinic pathological characteristic and serum CA-125 level were analyzed. The mean age of women was 32.22±6.91. The mean serum CA-125 level was 49.93±4.30 U/mL. There was a significant correlation between the endometriosis stage, lesion size, adhesion score and preoperative CA-125 plasma concentration. However, we did not found significant differences in age, marital status, patient's complaints, and pelvic pain associated to Ca125 serum level. The suggested preoperative serum cut-off levels in premenopausal and postmenopausal patients were 37 U/ml and 35 U/ml, respectively. According to the results, preoperative serum CA-125 is an important predictor for patients with endometriosis and it should be taken into consideration when surgical management is suspected, especially if stage of disease, lesion size and adhesion score are undertaken.

  3. Electrophysiologic and clinico-pathologic characteristics of statin-induced muscle injury

    Directory of Open Access Journals (Sweden)

    Mohammed Abdulrazaq

    2015-08-01

    Conclusion: Atorvastatin increased average creatine kinase, suggesting, statins produce mild muscle injury even in asymptomatic subjects. Diabetic statin users were more prone to develop muscle injury than others. Muscle fiber conduction velocity evaluation is recommended as a simple and reliable test to diagnose statin-induced myopathy instead of invasive muscle biopsy.

  4. Clinico-pathomorphological study on schizophrenia using magnetic resonance imaging (MRI)

    International Nuclear Information System (INIS)

    Uematsu, Masayuki

    1990-01-01

    Forty two schizophrenic patients and 28 normal controls underwent magnetic resonance imaging (MRI) examination of the brain. All subjects were consenting males under 50 years old. The enlargement of the third ventricle, anterior one third of the corpus callosum, and the septum pellucidum significantly differentiated schizophrenics from controls by a discriminant analysis. These findings may not be changes that appeared in the process of illness, but might have existed before the onset of the disorder. MRI measurements which significantly differentiated familial patients from non-familial patients using a discriminant analysis included the enlargement of the third ventricle, the cerebellar vermis, and the septum pellucidum. Negative symptoms and anergia symptoms depended on the degree of atrophy of the frontal lobe and the enlargement of the septum pellucidum. Poor heterosexual relations and low levels of education depended on the enlargement of the anterior one third of the corpus callosum. The good therapeutic response to neuroleptics in schizophrenics was associated with a small cerebellar vermis. All these findings suggested that combining morphological changes in the brain as illustrated by MRI with clinical variables may provide a useful new approach to subclassifying of schizophrenia. (author) 77 refs

  5. Clinico-morphological changes and diagnosis of animal poisoning with mercury preparations

    Energy Technology Data Exchange (ETDEWEB)

    Tishkov, A I

    1976-01-01

    This paper examines animal poisoning with mercury compounds used to dress seeds. Chickens, guinea pigs, and mice were fed plants grown from seeds dressed with mercury compounds. The chickens exhibited stomatitis, pharyngitis, esophagitis, and leukocytosis. The guinea pigs and mice exhibited a biological accumulation of mercury.

  6. Primary Small Cell Carcinoma of the Esophagus: Clinico- pathological Features and Therapeutic Options.

    Science.gov (United States)

    Nevárez, Andrea; Saftoiu, A; Bhutani, M S

    2011-01-01

    Primary esophageal small cell carcinoma (SmCC) is a rare disease with a poor prognosis despite agressive multimodality combination treatment. This article presents the case of a 76-year old women diagnosed with pimary esophageal SmCC. The diagnosis was established by upper gastrointestinal endoscopy with biopsies that confirmed an esophageal SmCC positive to synaptophysin, chromogranin, CD56, TTF-1, and cytokeratin 8/18. Further staging procedures included CT, PET and EUS, followed by combination chemotherapy and radiotherapy. Restaging was then performed, again with PET and CT of the thorax, abdomen and pelvis. This was then followed by salvage esophagectomy due to the presence of residual tumor. Surgical pathology confirmed a 3 cm SmCC, with invasion of the submucosa and lymphovascular invasion. In conclusion, the article describes the rare occurrence of esophageal SmCC, together with the algorithm of diagnosis and staging based on state-of-the-art imaging methods. This was followed by combination chemoradiotherapy and surgical esophagectomy as the standard of care in this aggressive disease.

  7. CLINICO-EPIDEMIOLOGY AND THERAPEUTIC OUTCOME OF SNAKE BITE IN KONASEEMA REGION OF ANDHRA PRADESH

    Directory of Open Access Journals (Sweden)

    Sai Krishna

    2016-03-01

    Full Text Available INTRODUCTION Snake bite is a common and frequently devastating environmental and occupational problem, especially in rural areas of tropical developing countries. Snake bite incidence is high in Andhra Pradesh. With the onset of monsoon the incidence of snake bite used to increase. METHODS Present study is a retrospective study in which all the data of snake bite cases admitted in the Konaseema Institute of Medical Sciences was collected in last two years; details of the patient was obtained from bed head ticket. RESULTS In two years of data collection, 46 snake bite cases are found as per our record. Out of 46 patients, twenty seven were male and nineteen were female. Maximum twenty two (22 patients were between ages 20 to 40 years. Out of forty six patients, forty four recovered and only two patients died, cause of death was acute pulmonary oedema with cardiac arrhythmia. DISCUSSION Most of the patients were given ASV (anti-snake venom, out of that only four patients developed reaction to ASV. Most of the patients who have received ASV were recovered. Only two deaths were reported which was due to acute pulmonary oedema with cardiac arrhythmia. CONCLUSION Awareness and education about snake is required.

  8. Clinico-epidemiological profile of malaria: Analysis from a primary health centre in Karnataka, Southern India

    Directory of Open Access Journals (Sweden)

    Ramachandra Kamath

    2012-01-01

    Full Text Available Malaria continues to be a major public health problem in India and worldwide. The present study was based on records from a primary health centre in Karnataka. Morbidity patterns and important features of malaria transmission specific to Udupi district were investigated. The incidence of malaria and various morbidity patterns during 2010 and 2011 were compared and analyzed. Factors such as rapid urbanization, increased construction activities and influx of migratory workers were highlighted as the leading causes for the advent of malaria in the area. Recommendations have been provided for implementation in the near future.

  9. Renal cancer in Maiduguri: an 8-year review of clinico-pathological ...

    African Journals Online (AJOL)

    Methods: All patients with malignancies of the kidney seen between January 1999 and December 2007 were included in the study. These patients had surgery alone or in combination with preoperative/postoperative chemotherapy or radiotherapy and all specimens were confirmed malignant on histopathological ...

  10. Clinico-epidemiological profile of malaria: Analysis from a primary health centre in Karnataka, Southern India

    Directory of Open Access Journals (Sweden)

    Ramachandra Kamath

    2013-01-01

    Full Text Available Malaria continues to be a major public health problem in India and worldwide. The present study was based on records from a primary health centre in Karnataka. Morbidity patterns and important features of malaria transmission specific to Udupi district were investigated. The incidence of malaria and various morbidity patterns during 2010 and 2011 were compared and analyzed. Factors such as rapid urbanization, increased construction activities and influx of migratory workers were highlighted as the leading causes for the advent of malaria in the area. Recommendations have been provided for implementation in the near future.

  11. Clinico-pathological study on non-squamous cell carcinomas of the oral cavity and oropharynx

    International Nuclear Information System (INIS)

    Chijiwa, Hideki; Sakamoto, Kikuo; Umeno, Hirohito; Nakashima, Tadashi; Suzuki, Gen; Hayabuchi, Naohumi

    2007-01-01

    We reviewed 22 cases of non-squamous cell carcinoma (NSCC) of the oral cavity and oropharynx that were treated at the Kurume University Hospital between 1976 and 2005. Two percent of the oral carcinomas and 5% of the oropharyngeal carcinomas were NSCCs. The 5-year and 10-year survival rates of NSCC in the oropharynx were 90%. There was no statistically significant difference in survival rate between squamous cell carcinoma (SCC) and NSCC (p=0.06). The 5-year and 10-year survival rates of NSCC in the oral cavity were 75% and 37%, respectively. There was no statistically significant difference in the survival rate between SCC and NSCC. Survival results well correlated with clinical stages. A significant difference between Stage I, II and III versus Stage IV was found (p=0.04). In contrast, no significant relationship was found between survival and histologic type, or between survival and treatment. Patients with adenoid cystic carcinoma of Grade III, peri-neural invasion or vessel invasion, are recommended to receive adjuvant therapy. (author)

  12. Port-site infections by nontuberculous mycobacterium: A retrospective clinico-microbiological study

    Directory of Open Access Journals (Sweden)

    Roumi Ghosh

    2017-01-01

    Full Text Available Background: Port-site infection (PSI is a prevailing, chronic, nagging, treatment refractory complication of laparoscopic surgery (LS. It neutralizes the advantages of minimally invasive surgery and increases morbidity, treatment cost of patient, leading to loss of confidence on operating surgeon. PSIs are preventable with appropriate preoperative, intraoperative, and postoperative measures. Atypical mycobacterium is most commonly associated with nonhealing postlaparoscopic wound infections, causing outbreaks or sporadic cases worldwide. Purpose: We retrospectively studied the occurrence of nontuberculous mycobacterium (NTM from PSIs following LS that did not respond to antibiotics used for pyogenic infections and having sterile routine aerobic cultures and their antimicrobial susceptibility pattern to guide proper management. Methods: The study was done in a tertiary care hospital of Eastern India over a 1-year period which included PSI cases with delayed onset not responding to antibiotics, following different types of LS. Pus/discharge from 32 patients was collected and examined for isolation and identification of the causative agents. Gram stain and Ziehl–Neelsen staining methods were used for direct examination. Culture media included blood agar, Robertson's cooked meat broth, MacConkey agar, and Lowenstein–Jensen medium. Isolates from the cases were identified using biochemical tests or molecular methods and studied the antimicrobial susceptibility pattern by the standard microbiologic procedures. Results: Mycobacterium abscessus (13 and Mycobacterium fortuitum (2 were isolated from 15 serosanguinous drainage obtained from 32 cases by routine microbiological techniques. All isolates analyzed for antimicrobial susceptibility pattern were highly sensitive to clarithromycin (93.3%, amikacin (93.3%, and imipenem (80% but were variable to ciprofloxacin, ofloxacin, and linezolid. Conclusions: Our present study shows frequent association of NTM with laparoscopic port-site nonhealing chronic infection or wound dehiscence. Although direct microscopy can give us a clue to diagnosis, culture isolation is required for speciation and antimicrobial susceptibility testing, which helps formulate therapeutic regimen.

  13. Human prion diseases in The Netherlands : clinico-pathological, genetic and molecular aspects

    NARCIS (Netherlands)

    Jansen, C.

    2011-01-01

    Prion diseases, or transmissible spongiform encephalopathies (TSEs), are invariably fatal neurodegenerative disorders that can be sporadic, inherited or acquired by infection. In humans, TSEs comprise three major groups showing a wide phenotypic heterogeneity: Creutzfeldt-Jakob disease (CJD),

  14. The FREGAT biobank: a clinico-biological database dedicated to esophageal and gastric cancers.

    Science.gov (United States)

    Mariette, Christophe; Renaud, Florence; Piessen, Guillaume; Gele, Patrick; Copin, Marie-Christine; Leteurtre, Emmanuelle; Delaeter, Christine; Dib, Malek; Clisant, Stéphanie; Harter, Valentin; Bonnetain, Franck; Duhamel, Alain; Christophe, Véronique; Adenis, Antoine

    2018-02-06

    While the incidence of esophageal and gastric cancers is increasing, the prognosis of these cancers remains bleak. Endoscopy and surgery are the standard treatments for localized tumors, but multimodal treatments, associated chemotherapy, targeted therapies, immunotherapy, radiotherapy, and surgery are needed for the vast majority of patients who present with locally advanced or metastatic disease at diagnosis. Although survival has improved, most patients still present with advanced disease at diagnosis. In addition, most patients exhibit a poor or incomplete response to treatment, experience early recurrence and have an impaired quality of life. Compared with several other cancers, the therapeutic approach is not personalized, and research is much less developed. It is, therefore, urgent to hasten the development of research protocols, and consequently, develop a large, ambitious and innovative tool through which future scientific questions may be answered. This research must be patient-related so that rapid feedback to the bedside is achieved and should aim to identify clinical-, biological- and tumor-related factors that are associated with treatment resistance. Finally, this research should also seek to explain epidemiological and social facets of disease behavior. The prospective FREGAT database, established by the French National Cancer Institute, is focused on adult patients with carcinomas of the esophagus and stomach and on whatever might be the tumor stage or therapeutic strategy. The database includes epidemiological, clinical, and tumor characteristics data as well as follow-up, human and social sciences quality of life data, along with a tumor and serum bank. This innovative method of research will allow for the banking of millions of data for the development of excellent basic, translational and clinical research programs for esophageal and gastric cancer. This will ultimately improve general knowledge of these diseases, therapeutic strategies and patient survival. This database was initially developed in France on a nationwide basis, but currently, the database is available for worldwide contributions with respect to the input of patient data or the request for data for scientific projects. The FREGAT database has a dedicated website ( www.fregat-database.org ) and is registered on the Clinicaltrials.gov site, number NCT 02526095 , since August 8, 2015.

  15. Paraplegia espastica familiar com amiotrofia: estudo clinico, eletromiografico, histoquimico e microdissecção

    Directory of Open Access Journals (Sweden)

    Lineu Cesar Werneck

    1979-06-01

    Full Text Available Relato de quatro casos de paraplegia, espástica familiar com amiotrofia, em irmãos provenientes de um matrimônio consanguíneo. A investigação laboratorial rotineira estava normal. A eletromiografia e biópsia muscular com histoquímica demonstraram denervação com reinervação. As conduções nervosas motoras estavam diminuídas em três casos no nervo peroneiro. A análise por microdissecção do nervo sural foi anormal nos quatro casos, revelando desmielinização e remielinização. Após revisão da literatura, os autores acreditam que as alterações encontradas são decorrentes de degeneração axonal distai, com regeneração secundária e levantam a hipótese de defeito no fluxo axoplásmico do sistema nervoso central e periférico.

  16. Mielopatia necrotizante e neoplasias: registro clinico-patologico de dois casos

    Directory of Open Access Journals (Sweden)

    Marcos R. G. de Freitas

    1983-06-01

    Full Text Available São relatados dois casos de mielopatia transversa subaguda associada a tumores malignos. O primeiro paciente apresentava neoplasia de células reticulares histiocitárias e o segundo, carcinoma renal. Os autores fazem revisão dos casos similares descritos na literatura. As alterações anátomo-patológicas medulares encontradas foram semelhantes às descritas nos relatos prévios, sendo que no primeiro caso havia também intenso infiltrado inflamatório perivascular e a presença de astrócitos bizarros. Tais alterações encontradas sugerem ser esta afecção de natureza viral.

  17. Tratamento do câncer de esôfago: ensaio clinico controlado

    Directory of Open Access Journals (Sweden)

    Antonio Pedro Mirra

    Full Text Available Realização de ensaio clínico controlado em câncer de esôfago, com uma casuística de 65 casos, no Hospital A.C. Camargo, no período de 1986 a 1990. O ensaio clínico controlado estudou três grupos terapêuticos: grupo I - cirurgia exclusiva (20 casos; grupo 2 - cirurgia + radioterapia pós-operatória (27 casos; grupo 3 - quimioterapia pré-operatória + cirurgia + radioterapia e quimioterapia pós-operatória (18 casos. O tempo cirúrgico foi único, com ressecção ampla do esôfago, utilizando-se como vias de acesso, preferentemente, a transpleural para os tumores localizados no terço médio do esôfago e a transmediastinal para o terço inferior e segmento abdominal. A retirada dos gânglios linfáticos regionais fez parte deste tempo cirúrgico, bem como a técnica de plastia padronizada com o estômago, com anastomose extratorácica cervical e posição do estômago no mediastino posterior. A radioterapia foi aplicada no leito esofágico, com dose total de 4.500 a 5.000 cGY em cinco sessões semanais. Foram utilizadas as drogas cisplatina (80 mg/m², vincristina (1,5 mg/m² e bleomicina (10mg/m² na quimioterapia pré e pós-operatórias. A sobrevida de cinco anos, segundo os grupos terapêuticos, foi de: grupo I - 61,9% , grupo 2 - 52,6 % e grupo 3 - 68,7%. Esta sobrevida, segundo o estadiamento clínico, foi de: EC I+II A - 52,0% e EC II B + III- 45,5%. Esses resultados estatisticamente não foram significativos. Os índices de sobrevida de cinco anos para os grupos terapêuticos 1 e 2 variaram de 40,4 a 60,6% quando os EC foram I + II A; para os demais EC não houve sobrevida de cinco anos. Para uma melhor avaliação, a inclusão de maior número de casos em pesquisas desse tipo poderia ser obtida pela participação de vários centros de tratamento do câncer de esôfago.

  18. Neurocisticercose na infância: I. diagnóstico clinico e laboratorial

    Directory of Open Access Journals (Sweden)

    L. Bruck

    1991-03-01

    Full Text Available Foram revisados aspectos clínicos e laboratoriais de 34 casos de neurocisticercose na infância (15 meses a 13 anos. Os principais sintomas foram: hipertensão intracraniana, 21 casos (62%; epilepsia, 20 casos (59%; hemiplegia, 4 casos (12%. A tomografia computadorizada de crânio (TAC (33 pacientes mostrou cistos em atividade em 26 (79% e calcificações em 2 (6%. A reação de fixação de complemento ou imunofluorescência para cisticercose foi reagente em 77% no LCR (20/26 pacientes e 78% no soro (18/23 pacientes. Pleocitose no LCR ocorreu em 57% dos casos (15/26 pacientes e eosinofilorraquia em 27% (7/26 pacientes. A TAC foi o melhor exame para o diagnóstico, confirmado pelos testes imunológicos no LCR e soro.

  19. The epileptology of Koolen-de Vries syndrome: Electro-clinico-radiologic findings in 31 patients.

    Science.gov (United States)

    Myers, Kenneth A; Mandelstam, Simone A; Ramantani, Georgia; Rushing, Elisabeth J; de Vries, Bert B; Koolen, David A; Scheffer, Ingrid E

    2017-06-01

    This study was designed to describe the spectrum of epilepsy phenotypes in Koolen-de Vries syndrome (KdVS), a genetic syndrome involving dysmorphic features, intellectual disability, hypotonia, and congenital malformations, that occurs secondary to 17q21.31 microdeletions and heterozygous mutations in KANSL1. We were invited to attend a large gathering of individuals with KdVS and their families. While there, we recruited individuals with KdVS and seizures, and performed thorough phenotyping. Additional subjects were included who approached us after the family support group brought attention to our research via social media. Inclusion criteria were genetic testing results demonstrating 17q21.31 deletion or KANSL1 mutation, and at least one seizure. Thirty-one individuals were studied, aged 2-35 years. Median age at seizure onset was 3.5 years, and 9 of 22 had refractory seizures 2 years after onset. Focal impaired awareness seizures were the most frequent seizure type occurring in 20 of 31, usually with prominent autonomic features. Twenty-one patients had prolonged seizures and, at times, refractory status epilepticus. Electroencephalography (EEG) showed focal/multifocal epileptiform discharges in 20 of 26. MRI studies of 13 patients were reviewed, and all had structural anomalies. Corpus callosum dysgenesis, abnormal hippocampi, and dilated ventricles were the most common, although periventricular nodular heterotopia, focal cortical dysplasia, abnormal sulcation, and brainstem and cerebellum abnormalities were also observed. One patient underwent epilepsy surgery for a lesion that proved to be an angiocentric glioma. The typical epilepsy phenotype of KdVS involves childhood-onset focal seizures that are prolonged and have prominent autonomic features. Multifocal epileptiform discharges are the typical EEG pattern. Structural brain abnormalities may be universal, including signs of abnormal neuroblast migration and abnormal axonal guidance. Epilepsy surgery should be undertaken with care given the widespread neuroanatomic abnormalities; however, tumors are a rare, yet important, occurrence. Wiley Periodicals, Inc. © 2017 International League Against Epilepsy.

  20. Psicoterapia de grupo de criança : aspectos clinicos de um estudo de caso

    OpenAIRE

    Regina Celia Ciriano Calil

    2001-01-01

    Resumo: Essa tese de doutorado tem o objetivo de efetuar um estudo de caso referente ao atendimento de um grupo de psicoterapia realizado com crianças em idade escolar, no contexto institucional do Ambulatório de Saúde Mental Infantil do Hospital das Clínicas da Unicamp. Para o atendimento do grupo estudado, utilizou-se a técnica de psicoterapia infantil de abordagem psicodinâmica, adaptada à condição de trabalho grupal e às circunstâncias institucionais. Nesse estudo de caso, foram analisad...

  1. Clinico-radiological profile and risk factors in patients with anthracosis

    Directory of Open Access Journals (Sweden)

    Virendra Singh

    2015-01-01

    Full Text Available Background: Anthracosis is the black pigmentation of the mucosal lining of the tracheo-bronchial tree. The significance of this finding is not known and often ignored. The aim of the present study is to find the association of anthracosis with demographic variables, biomass fuel and occupational exposure, respiratory diseases, radiological pattern and functional morbidity. Materials and Methods: Enrolment of the subjects for the study was done at SMS hospital, Jaipur. Patients with anthracosis evident on bronchoscopy were included as the cases. Patients without anthracosis on bronchoscopy, matched according to age, gender and smoking habits, were included in the control group. Subjects in both the arms completed a questionnaire and also underwent computed tomography (CT of the chest and six minute walk test (6MWT. Results: Thirty cases and 53 controls were included in the study. The patients with anthracosis presented with symptoms ranging from cough (76.65%, hemoptysis (46.6%, fever (26.6%, dyspnea (90% and malaise (73.3%. Biomass fuel exposure for the cases was 35.13 ± 55.86 hours in a year and for the controls was 28.15 ± 40.09 hours in a year (P > 0.05. Stone mining was significantly associated with anthracosis (P < 0.05. CT chest revealed fibrosis (43.3%, consolidation (33.3%, cavitation (16.6% and mass (46.6% in the cases. Sixty percent of cases and 15% of controls were diagnosed to have either old or active pulmonary tuberculosis (P < 0.05. Conclusions: Anthracosis is associated with pulmonary tuberculosis. Biomass exposure is not significantly associated with anthracosis. Post tubercular fibrosis is more common on CT chest of patients with anthracosis.

  2. Clinico-radiographic Studies on The Prevalent Distal Limb Affections in Working Equine at Luxor City

    OpenAIRE

    A. A.A. Abdel-Hady; M.A. Sadan; Asmaa A. Metwally; A.S. Soliman

    2017-01-01

    To illustrate the clinical and radiographic findings of some distal limbs affections in Ninety two animals (24 horses and 68 donkeys) which were admitted to Animal Care Hospital in Luxor. Each animal was subjected to thorough clinical and radiographic examination; the grade of lameness was recorded and the best radiographic views were taken.  Fifteen types of distal limb affections were evident. The most prevalent affections in donkeys were high and low ring bone (29.35%) and hoof abscess ( 9...

  3. Clinical and tomographic aspects of macular microholes; Aspectos clinicos e tomograficos dos microburacos maculares

    Energy Technology Data Exchange (ETDEWEB)

    Novelli, Fernando Jose de [Hospital de Olhos Sadalla Amin Ghanem, Joinville, SC (Brazil)], e-mail: Fernando.novelli@gmail.com; Maia Junior, Otacilio de Oliveira [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael; Nobrega, Mario Junqueira [Universidade da Regiao de Joinville (UNIVILLE), Joinville, SC (Brazil); Garrido Neto, Theodomiro [Universidade do Estado do Amazonas (UEA), Manaus, AM (Brazil); Takahashi, Walter Yukihiko [Universidade de Sao Paulo (USP), SP (Brazil). Hospital das Clinicas. Dept. de Oftalmologia

    2009-07-01

    Purpose: To describe the clinical aspects and evaluate optical coherence tomography of macular microholes. Methods: Seven patients were assessed (8 eyes) with microholes of the macula. All patients underwent complete eye examination, fundus photography, fluorescent angiography and OCT-3 imaging. Results: Ages ranged from 26 to 69 years. Six patients were female (85.7%) and five of them had microhole in the right eye. The presenting symptom was decrease in visual acuity (71.3%) and central scotoma in (14.3%). Five eyes (71.4%) had no defects shown by fluorescent angiography. A defect in the outer retina was demonstrated in all eyes on optical coherence tomography. The lesions were nonprogressive. Conclusion: Macular microholes are small lamellar defects in the outer retina. The condition is nonprogressive, generally unilateral and compatible with good visual acuity. Fundus biomicroscopy associated with an optical coherence tomography are the main elements in the diagnosis and study of this pathology. (author)

  4. Clinico-laboratoral estimation of medioprophylactic toothpastes efficiency in caries prophylaxis

    Directory of Open Access Journals (Sweden)

    Sorochenko G.V.

    2011-03-01

    Full Text Available In experimental and clinical conditions the influence of medioprophylactic toothpastes with different fluoride compounds on enamel structural and functional characteristic of permanent teeth on the stage of secondary mineralization was studied. In the experimental part qualitive and quantative chemical test of the superficial enamel layer in 80 samples was made. Using secondary ion masspectrometry method the quality of fluoride and calcium ions enamel penetration was tested. Using radiophotoelectronic spectroscopy the number of fluoride, calcium and phosphorus ions was evaluated. The insufficient level of permanent teeth enamel mineralization after eruption and its changes due to the influence of different fluoride compound was shown. 88 schoolchildren of 12 years old were examined. The influence of fluoride containing toothpastes on hard tooth tissues, structural-functional enamel caries resistance and saliva mineralisation ability was stydied. The correlation beetwen studied parameters and fluoride compound, its concentration and the term of usage was found

  5. Comparison of Clinico-Radiological Features between Congenital Cystic Neuroblastoma and Neonatal Adrenal Hemorrhagic Pseudocyst

    Energy Technology Data Exchange (ETDEWEB)

    Eo, Hong; Kim, Ji Hye; Jang, Kyung Mi; Yoo, So Young [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lim, Gye Yeon [St. Mary' s Hospital Catholic University, Seoul (Korea, Republic of); Kim, Myung Joon [Severance Hospital Yonsei University, Seoul (Korea, Republic of); Kim, Ok Hwa [Ajou University Hospital, Suwon (Korea, Republic of)

    2011-02-15

    To evaluate the radiological and clinical findings of congenital cystic neuroblastomas as compared with those of the cystic presentation of neonatal adrenal hemorrhage. We analyzed the US (n = 52), CT (n = 24), and MR (n = 4) images as well as the medical records of 28 patients harboring congenital cystic neuroblastomas (n = 16) and neonatal adrenal hemorrhagic pseudocysts (n = 14). The history of prenatal detection, location, size, presence of outer wall enhancement, internal septations, solid portion, calcification, turbidity, vascular flow on a Doppler examination, and evolution patterns were compared in two groups of cystic lesions, by Fischer's exact test. All (100%) neuroblastomas and three (21%) of the 14 hemorrhagic pseudocysts were detected prenatally. Both groups of cystic lesions occurred more frequently on the right side; 11 of 16 (69%) for neuroblastomas and 11 of 14 (79%) for hemorrhagic pseudocysts. The size, presence of solid portion, septum, enhancement, and turbidity did not differ significantly (p > 0.05) between the two groups of cystic lesions. However, tiny calcifications (n = 3) and vascular flow on color Doppler US (n = 3) were noted in only neuroblastomas. The cystic neuroblastomas became complex solid and cystic masses, and did not disappear for up to 90 days in the three following cases, whereas 11 of the 14 (79%) hemorrhagic pseudocysts disappeared completely and the three remaining (27%) evolved to calcifications only. Although the imaging findings of two groups of cystic lesions were similar, prenatal detection, the presence of calcification on initial images, vascularity on color Doppler US, and evolution to a more complex mass may all favor neuroblastomas

  6. EVALUACION DEL COMPORTAMIENTO BIOLOGICO, CLINICO Y MICROBIOLOGICO DE RESINAS DE ULTIMA GENERACION

    OpenAIRE

    Velermoro, Victor; Moromi, Hilda; Gálvez, Luis; Salcedo, Doris; Paz F., Juan José; Quintana, Carmen; Ayala, Gerardo

    2014-01-01

    An study of three clases of resins of last generation was done evaluating the clinical conduct histological, microbiological and microfiltración through electronical microscopic concluting that the clinical answer in the three tippies of resins in casties of 3 mm of intensity were not present, in histologic grade you cannot see qualitive changes, in the microbiological aspect it was verified y kal the efect antimi crobianie is only produced with direct contact with the resens through the shap...

  7. Comparison of Clinico-Radiological Features between Congenital Cystic Neuroblastoma and Neonatal Adrenal Hemorrhagic Pseudocyst

    International Nuclear Information System (INIS)

    Eo, Hong; Kim, Ji Hye; Jang, Kyung Mi; Yoo, So Young; Lim, Gye Yeon; Kim, Myung Joon; Kim, Ok Hwa

    2011-01-01

    To evaluate the radiological and clinical findings of congenital cystic neuroblastomas as compared with those of the cystic presentation of neonatal adrenal hemorrhage. We analyzed the US (n = 52), CT (n = 24), and MR (n = 4) images as well as the medical records of 28 patients harboring congenital cystic neuroblastomas (n = 16) and neonatal adrenal hemorrhagic pseudocysts (n = 14). The history of prenatal detection, location, size, presence of outer wall enhancement, internal septations, solid portion, calcification, turbidity, vascular flow on a Doppler examination, and evolution patterns were compared in two groups of cystic lesions, by Fischer's exact test. All (100%) neuroblastomas and three (21%) of the 14 hemorrhagic pseudocysts were detected prenatally. Both groups of cystic lesions occurred more frequently on the right side; 11 of 16 (69%) for neuroblastomas and 11 of 14 (79%) for hemorrhagic pseudocysts. The size, presence of solid portion, septum, enhancement, and turbidity did not differ significantly (p > 0.05) between the two groups of cystic lesions. However, tiny calcifications (n = 3) and vascular flow on color Doppler US (n = 3) were noted in only neuroblastomas. The cystic neuroblastomas became complex solid and cystic masses, and did not disappear for up to 90 days in the three following cases, whereas 11 of the 14 (79%) hemorrhagic pseudocysts disappeared completely and the three remaining (27%) evolved to calcifications only. Although the imaging findings of two groups of cystic lesions were similar, prenatal detection, the presence of calcification on initial images, vascularity on color Doppler US, and evolution to a more complex mass may all favor neuroblastomas

  8. A study of clinico-epidemiological and dermoscopic patterns of vitiligo in pediatric age group

    Directory of Open Access Journals (Sweden)

    Sneha Gandhi

    2017-01-01

    Conclusions: Vitiligo prevalence among children is on the rise and clinicoepidemiological data on this disease in between far and few. We found that dermoscopy was able to pick up disease activity earlier than the clinical onset of disease instability. This is the first study analyzing the dermoscopic pattern in pediatric vitiligo to the best of our knowledge.

  9. Demographic and clinico-epidemiological features of dengue fever in Faisalabad, Pakistan.

    Directory of Open Access Journals (Sweden)

    Faiz Ahmed Raza

    Full Text Available This cross-sectional study was carried out to explore the epidemiological and clinical features of dengue fever in Faisalabad, Pakistan during 2011 and 2012. During the study period, anti-dengue IgM positive cases were reported in the post-monsoon period during the months of August-December. Certain hotspots for the dengue infection were identified in the city that coincide with the clusters of densely populated urban regions of the city. Out of total 299 IgM positive patients (male 218 and female 81; there were 239 dengue fever (DF and 60 dengue hemorrhagic fever (DHF patients. There was decrease in the median age of dengue patients from 31 years in 2011 to 21.5 years in 2012 (p<0.001. Abdominal pain was seen in 35% DHF patients followed by nausea in 28.3%, epistaxis in 25% and rash in 20% patients (p<0.05. Patients reported to be suffering from high-grade fever for an average of 8.83 days in DHF as compared to 5.82 days in DF before being hospitalized. Co-morbidities were found to be risk factor for the development of DHF in dengue patients. Clinical and laboratory features of dengue cases studied could be used for the early identification of patients at risk of severe dengue fever.

  10. A clinico-pathologic review of 56 cases of ossifying fibroma of the ...

    African Journals Online (AJOL)

    Materials and Methods: A total of 80 patients who were diagnosed either as cementifying fibroma CF, OF and cemento.ossifying fibroma (COF) of the jaws from the files of the Oral Pathology Department of the University of the Witwatersrand Dental School were retrieved and the histology slides of each case were reviewed ...

  11. Angiogenesis in non-Hodgkin's lymphoma: clinico-pathological correlations and prognostic significance in specific subtypes

    DEFF Research Database (Denmark)

    Jørgensen, J M; Sørensen, Flemming Brandt; Bendix, K

    2007-01-01

    The aim of the study was to evaluate angiogenesis in different subtypes of non-Hodgkin's lymphoma (NHL) and to correlate angiogenic scores to clinical endpoints. Pre-therapeutic lymph node biopsies from 308 patients with NHL [107 follicular B-cell lymphoma (FL), 94 diffuse large B-cell lymphoma...

  12. A COMPARITIVE STUDY OF CLINICO-RADIOLOGICAL OUTCOME: DHS VERSES PFLCP IN INTERTROCHANTRIC FRACTURES OF FEMUR

    Directory of Open Access Journals (Sweden)

    Vanamali B

    2015-11-01

    Full Text Available INTRODUCTION: There have been many case series advocating the potential benefits of PFLCP for fixation of intertrochanteric fractures. But these studies are lacking in terms of guidelines regarding the type of fractures in which PFLCP has an upper hand over the gold standard implant that is the DHS. Moreover there have been very few control studies comparing these two implants. Therefore, we performed a case control study to assess: (1 If PFLCP offers better functional results and fewer complications than dynamic hip screws (DHS? (2 Which kind of extracapsular femoral fractures would benefit from PFLCP fixation? PATIENTS AND METHODS: A total of 60 patients with intertrochanteric femoral fractures were recruited. Thirty patients underwent PFLCP fixation, and thirty patients underwent DHS fixation. Patient information, type of fracture, functional level (as assessed by Harris hip score, bone union, and implant complications were compared for the two treatment groups. RESULTS: The Mean duration for union in PFLCP group was 17 Weeks (12-24 weeks. The Mean duration for union in DHS group was 16 Weeks (12-28 weeks. Although there were better functional results (Harris Hip Score in PFLCP group when compared to DHS group the difference was not statistically significant (P value= 0.06 in our study. The complications like fracture of the lateral cortex, shortening >2cm, rotational deformity, varus mal-union screw cut off phenomenon, plate lift off were more in DHS group when compared to PFLCP. CONCLUSION: We conclude that there was no major difference between DHS and PFLCP for stable intertrochanteric fractures and PFLCP is a better alternative in fixing osteoporotic and unstable intertrochanteric fractures. Further large case control studies are needed in this regard.

  13. Uncertainty sources in radiopharmaceuticals clinical studies; Fontes de incertezas em estudos clinicos com radiofarmacos

    Energy Technology Data Exchange (ETDEWEB)

    Degenhardt, Aemilie Louize; Oliveira, Silvia Maria Velasques de, E-mail: silvia@cnen.gov.br, E-mail: amilie@bolsista.ird.gov.br [Instituto de Radioprotecao e Dosimetria, (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2014-07-01

    The radiopharmaceuticals should be approved for consumption by evaluating their quality, safety and efficacy. Clinical studies are designed to verify the pharmacodynamics, pharmacological and clinical effects in humans and are required for assuring safety and efficacy. The Bayesian analysis has been used for clinical studies effectiveness evaluation. This work aims to identify uncertainties associated with the process of production of the radionuclide and radiopharmaceutical labelling as well as the radiopharmaceutical administration and scintigraphy images acquisition and processing. For the development of clinical studies in the country, the metrological chain shall assure the traceability of the surveys performed in all phases. (author)

  14. Tumor estrogen content and clinico-morphological and endocrine features of endometrial cancer.

    Science.gov (United States)

    Berstein, L M; Tchernobrovkina, A E; Gamajunova, V B; Kovalevskij, A J; Vasilyev, D A; Chepik, O F; Turkevitch, E A; Tsyrlina, E V; Maximov, S J; Ashrafian, L A; Thijssen, J H H

    2003-04-01

    To compare estrogen concentrations in endometrial cancer tissue with those in macroscopically normal endometrium and with certain morphological characteristics of the tumor and endocrine parameters in patients. The estradiol content was evaluated by radioimmunoassay after homogenization and extraction in 78 adenocarcinomas (61 from postmenopausal patients). Higher concentrations of estradiol in tumor tissue samples than in macroscopically normal endometrium were found in patients of both reproductive and postmenopausal age. This difference was the same in patients with either endometrial carcinoma type I or type II. No association between tumor steroid receptor levels, estradiol concentrations in blood serum, and timing of menopause with intratumoral estradiol contents was discovered. Estradiol concentrations in tumor tissues correlated positively with the clinical stage of disease and rate of tumor invasion (in patients with peripheric/lower type of fat topography), and negatively with tumor differentiation stage (in patients with central/upper type of fat topography) and the percentage of intact double-stranded DNA in normal endometrium. Tumor estrogen content in endometrial cancer has clinical significance that is modified in the presence of certain endocrine characteristics related to insulin resistance. The role of local estrogen production (aromatase activity) in this setting deserves special study.

  15. Inflammatory myofibroblastic tumor of the orbit: A clinico-pathological study of 25 cases

    Directory of Open Access Journals (Sweden)

    Diego Strianese

    2018-01-01

    Full Text Available Background: Inflammatory myofibroblastic tumor (IMT is a rare entity characterized by the presence of myofibroblasts and inflammatory cells within a fibrous stroma, which typically occurs in children or young adults. The IMT is considered generally a benign lesion, although about 20% of cases may experience recurrence, and most rarely develop metastasis. Herein, we present the largest series of primary orbital IMT ever reported. Patients and methods: The clinical records of 25 patients, collected between the 1995 and 2015, with biopsy-proven diagnosis of orbital IMT were retrospectively reviewed to determine demographic, clinical, radiologic and pathological features, management, and outcome. Results: The study included 13 females and 12 male patients, age ranged from 5 to 76 years. Disease onset was in all cases unilateral (25/25, with posterior location (10/25 or extending anterior to posterior (7/25. The most common signs and symptoms were: proptosis (19/25, ptosis (18/25, diplopia (10/25, periocular swelling (9/25, pain (8/25, redness (7/25. All patients underwent to incisional biopsy which included total or subtotal tumor resection avoiding arming of the adjacent structure, followed by systemic steroid therapy (22/25 or radiotherapy (3/25. The disease recurred in 6 (24% patients who responded to the subsequent therapy. No one developed metastasis or died because of the disease. Conclusion: IMT is a distinct entity which may occur in the orbit primarily. It should be considered in differential diagnosis in all orbital masses, particularly with onset of acute or subcronic inflammation. Surgical biopsy associated to a partial debulcking of the tumor, avoiding to damage adjacent vital structure may contribute to improve the outcome. Steroid therapy, seems to be the suitable as first line medical therapy, although, as reported in literature, not all cases respond to this treatment regimen. Radiotherapy, may be considered as an alternative therapy. Recurrences occurred in 24% of patients and may be treated with additional surgical resection and a new course of steroid or radiotherapy. No specific pathological features which may correlate with the prognosis have been found in this series.

  16. Clinico-microbiological Profile of Septic Diabetic Foot with Special Reference to Anaerobic Infection.

    Science.gov (United States)

    Sasikumar, K; Vijayakumar, Chellappa; Jagdish, Sadasivan; Kadambari, Dharanipragada; Raj Kumar, Nagarajan; Biswas, Rakhi; Parija, Subhash Chandra

    2018-03-01

    Introduction Diabetic foot infections are a major cause of non-traumatic amputations. The role of anaerobes in the prognosis of these infections is particularly unclear. This study was conducted with the aim of correlating microbiological profiles with clinical outcomes in these diabetic foot ulcer patients. Methodology This prospective observational study was done in a tertiary care centre in South India. All patients admitted with diabetic foot ulcers for two years were included in the study. Tissue biopsies were collected from the ulcer for aerobic and anaerobic cultures. The patients were grouped as those with aerobic infection alone (anaerobe negative) and those with mixed aerobic and anaerobic infections (anaerobe positive). Anaerobic culture was performed using the Robertson cooked meat (RCM) medium. The ulcer of the foot was described with respect to site, size, duration, history of previous amputation(s), and history of number and class of antibiotic intake prior to hospitalization. Clinical course and Wagner's grades of the diabetic foot ulcers were compared for aerobic and anaerobic infections. Results A total of 104 patients were included in the study. There were no significant differences between the two groups with regards to duration of diabetes, random blood sugar (RBS) at the time of admission, compliance to drugs, and mode of blood sugar control and prior intake of antibiotics. Patients with anaerobic infections were found to have a higher incidence of fever in this study (38.1% vs. 14.5%; p = 0.0057), as compared to patients with aerobic infections. More than half of the patients in the anaerobic infection group presented with Wagner's grade IV and above, as compared to the aerobic infection group (59.5% vs. 32.2%; p = 0.0059), which was statistically significant. Patients with anaerobic infections also had high numbers of major and minor amputations when compared to patients with aerobic infections. Conclusion Septic diabetic foot patients with fever at the time of admission and a high Wagner's grade have a greater chance of harbouring anaerobic infections. Drugs for anaerobic coverage should be considered for wounds beyond Wagner's grade III. Anaerobic infections resulted in increased risk of morbidity in diabetic foot ulcer patients but did not have any influence on mortality.

  17. Sindrome de Landau Kleffner aspectos clinicos, eletrencefalograficos e psicossociais : estudo de seguimento a longo prazo

    OpenAIRE

    Marcos Henrique Coelho Duran

    2008-01-01

    Resumo: Objetivos: A Síndrome de Landau-Kleffner (SLK) é uma entidade rara, caracterizada por epilepsia e afasia. Ocorre em crianças com aquisição normal da linguagem, geralmente, entre 3 e 7 anos de idade. A evolução a longo prazo é controversa e pouco estudada. O presente estudo tem como objetivo verificar a evolução em uma série de sujeitos com diagnóstico de SLK, enfocando os aspectos clínicos, eletrencefalográficos, psicossociais e da qualidade de vida. Métodos: Trata-se de um estudo tra...

  18. THE STUDY OF CLINICO-AETIOLOGICAL PROFILE OF PANCYTOPENIA IN ELDERLY POPULATION

    Directory of Open Access Journals (Sweden)

    Vijayashree Thyagaraj

    2017-06-01

    Full Text Available BACKGROUND Pancytopenia is a common problem in clinical practice. Pancytopenia is defined as haemoglobin less than 9 gm/dL, total leucocyte count less than 4,000/dL and platelet count less than 1 lakhs/dL. Causes of pancytopenia vary from nutritional deficiencies, bone marrow failure status and malignancies. Pancytopenia is a common problem in geriatric population also. In this study, we try to find common causes of pancytopenia in geriatric population in a tertiary care hospital. MATERIALS AND METHODS 40 consecutive patients who are more than 60 years of age attending General Medicine Outpatient Department were included in the study. Pancytopenia due to acute infections like viral fever and sepsis were excluded. Patients suspected to be having malignancies like lymphadenopathy and hepatosplenomegaly were also excluded. These patients were subjected to detailed history taking and clinical examination. Routine investigations like complete blood count, peripheral smear, reticulocyte count, Coombs test, serum cobalamin levels, renal function tests and liver function tests were done. Bone marrow examination was done in cases where indicated. Upper gastrointestinal endoscopy and anti-intrinsic factor antibody and antiparietal cell antibody were done where indicated. RESULTS Out of 40 patients included in the study, 25 were males and 15 were females. 28 patients were aged between 60-70 years, 10 patients between 70-80 years and 2 were more than 80 years old. Mean age of the patients was 68 years. Fatigue was the most common symptom (70%, fever was seen in 15% cases, mild cognitive impairment was reported in 10% patients and bleeding manifestations were seen in 5% cases. Most common cause of pancytopenia was cobalamin deficiency (60%. Others causes were aplastic anaemia (7.5%, chronic liver disease (5%, myelodysplasia (5%, drug induced (2.5% and HIV associated (2.5% cases. In this study, we saw that most common of pancytopenia was cause of cobalamin deficiency. We found that mean MCV was 88 fL (p=0.2 in all these patients. CONCLUSION Vitamin B12 deficiency is the most common cause of pancytopenia in elderly population. Symptoms of vitamin B12 deficiency maybe vague in elderly. High index of suspicion is required for the diagnosis. Mean corpuscular volume may not be raised in all cases. Hence, all patients in geriatric population presenting with must be tested for vitamin B12 deficiency.

  19. BACK PAIN ASSOCIATED WITH INTERVERTEBRAL DISK DEGENERATION: MORPHOLOGICAL, GENETIC AND CLINICO-INSTRUMENTAL ASPECTS

    Directory of Open Access Journals (Sweden)

    N. A. Shostak

    2014-07-01

    Full Text Available Degenerative spine disease is one of the causes of back pain. Clinical types of pain and severity of inflammatory changes in the vertebral bodies depend on the activity of pro-inflammatory cytokines. Rate of development and progression of degenerative changes in the spine structures is genetically determined. Therapy of pain syndrome associated with a degenerative disc disease may include use of methods to restore damaged intervertebral disc structures, and also use of different combinations of anti-inflammatory and analgesics therapy.

  20. BACK PAIN ASSOCIATED WITH INTERVERTEBRAL DISK DEGENERATION: MORPHOLOGICAL, GENETIC AND CLINICO-INSTRUMENTAL ASPECTS

    Directory of Open Access Journals (Sweden)

    N. A. Shostak

    2011-01-01

    Full Text Available Degenerative spine disease is one of the causes of back pain. Clinical types of pain and severity of inflammatory changes in the vertebral bodies depend on the activity of pro-inflammatory cytokines. Rate of development and progression of degenerative changes in the spine structures is genetically determined. Therapy of pain syndrome associated with a degenerative disc disease may include use of methods to restore damaged intervertebral disc structures, and also use of different combinations of anti-inflammatory and analgesics therapy.

  1. Infusion sclerotherapy of microcystic lymphatic malformation: Clinico-radiological mid-term results

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Min; Lee, Seok Jong; Chung, Ho Yun; Huh, Seung; Kim, Hyung Kee [Dept. of urgery, Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2016-01-15

    A new sclerotherapy technique by slow mechanical infusion of sclerosant was validated for treatment of microcystic lymphatic malformation (mLM). Seventeen consecutive patients with mLM in extremities, cervicofacial area, and trunk were included (21.8 ± 21.5 years old, male:female = 5:12). All patients diagnosed as mLM were included. A total 4-32 mL 20-38% OK-432 solution was mechanically infused at the rate of 10 mL/hour into the mLM lesions. The treatment effect was estimated clinic-radiologically at the 4-month follow-up. Repeated sclerotherapy followed in the 6th month, if required. The therapeutic effect was evaluated using quantitative ultrasonographic examination including soft tissue thickness, cyst size and number. In 17 patients, total 31 infusion sclerotherapy sessions were performed and monitored for 425 ± 266 days. Fifteen patients (88%) showed improvement in all symptoms, signs, and ultrasonographic findings. In all cases, at least one finding presented improvement. The maximal number of cysts per ultrasonographic window and maximal diameter of the largest cyst decreased by 57 ± 57% and 51 ± 67%, respectively (p = 0.102, 0.004). The soft tissue thickness decreased by 18 ± 15% (p < 0.01). No significant complications such as distal lymphedema or skin necrosis occurred. Infusion sclerotherapy is a safe and effective treatment technique for microcystic LM, with improved outcome.

  2. Clinico-pathological findings in natural cases of "mascadera" in goats.

    Science.gov (United States)

    Micheloud, J F; Vera, T A; Colque Caro, L A; Gimeno, E J

    2018-02-01

    "Mascadera" is a chronic emaciating neuropathy affecting goats; it produces significant economic losses in many regions and its cause is unknown. Here, the histological lesions found in 15 animals naturally affected by the disease are described. Complete necropsy was performed and tissue samples were collected for histopathological study. Severe atrophy of the masseter and buccinator muscles and tongue was observed, as well as vacuolar degeneration of neurons in the nuclei of the trigeminal, facial, and glossopharyngeal nerves. No relevant lesions were observed in other tissues. These findings and the clinical signs are consistent with those observed by other authors in animals spontaneously and experimentally intoxicated with Prosopis juliflora. The disease may be due to consumption of a similar species present in our country that is still unknown. Further research on the etiology and pathogenesis of this disease is needed to establish appropriate prevention guidelines.

  3. Gestione del rischio clinico nell’ASL 3 Genovese: esperienze e prospettive

    OpenAIRE

    Bruno, Giovanni; Corbella, Angela; Giacobbe, Sara; Rebagliati, Bruna

    2009-01-01

    In recent years all the most authoritative healthcare organizations have underlined the importance of improving clinical risk management strategies to ensure patients safety and cost savings. This article describes a one-year experience in the contest of ASL 3 Genovese, showing the developement of a risk management project, its aims and its limits. An adequate risk management approach should be based on a “system approach”, which assumes that errors of individuals can’t be avoided, but the sy...

  4. Clinico-radiological features of subarachnoid hyperintensity on diffusion-weighted images in patients with meningitis

    Energy Technology Data Exchange (ETDEWEB)

    Kawaguchi, T., E-mail: madarafuebuki@yahoo.co.jp [Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Sakurai, K.; Hara, M. [Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Muto, M. [Department of Radiology, Okazaki City Hospital, Okazaki, Aichi (Japan); Nakagawa, M. [Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Tohyama, J. [Department of Radiology, Toyota-kai Medical Corporation Kariya Toyota General Hospital, Kariya, Aichi (Japan); Oguri, T. [Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Mitake, S. [Department of Neurology, Tosei General Hospital, Seto-shi, Aichi (Japan); Maeda, M. [Department of Radiology, Mie University School of Medicine, Tsu, Mie (Japan); Matsukawa, N.; Ojika, K. [Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Shibamoto, Y. [Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan)

    2012-04-15

    Aim: To investigate the clinical and radiological features of meningitis with subarachnoid diffusion-weighted imaging (DWI) hyperintensity. Materials and methods: The clinical features, laboratory data, and radiological findings, including the number and distribution of subarachnoid DWI hyperintense lesions and other radiological abnormalities, of 18 patients seen at five institutions were evaluated. Results: The patients consisted of eight males and 10 females, whose ages ranged from 4 months to 82 years (median 65 years). Causative organisms were bacteria in 15 patients, including Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Klebsiella pneumoniae, and Listeria monocytogenes. The remaining three were fungal meningitis caused by Cryptococcus neoformans. Subarachnoid DWI hyperintense lesions were multiple in 16 of the 18 cases (89%) and predominantly distributed around the frontal lobe in 16 of the 18 cases (89%). In addition to subarachnoid abnormality, subdural empyema, cerebral infarction, and intraventricular empyema were found in 50, 39, and 39%, respectively. Compared with paediatric patients, adult patients with bacterial meningitis tended to have poor prognoses (7/10 versus 1/5; p = 0.1). Conclusion: Both bacterial and fungal meningitis could cause subarachnoid hyperintensity on DWI, predominantly around the frontal lobe. This finding is often associated with poor prognosis in adult bacterial meningitis.

  5. Focal parenchymal lesions in community-acquired bacterial meningitis in adults: a clinico-radiological study

    Energy Technology Data Exchange (ETDEWEB)

    Katchanov, Juri [Campus Charite Mitte, Charite, Department of Neurology, Berlin (Germany); University Hospital Charite, Campus Benjamin Franklin, Department of Neurology, Berlin (Germany); Siebert, Eberhard; Klingebiel, Randolf [Campus Charite Mitte, Charite, Department of Neuroradiology, Berlin (Germany); Endres, Matthias [Campus Charite Mitte, Charite, Department of Neurology, Berlin (Germany); Charite-Universitaetsmedizin Berlin, Center for Stroke Research Berlin, Berlin (Germany)

    2009-11-15

    Here, we analyzed the frequency, morphological pattern, and imaging characteristics of focal lesions as a consequence of community-acquired bacterial meningitis. We hypothesized that diffusion-weighted imaging combined with contrast-enhanced imaging, serial scanning, and multimodal vascular studies would provide further insight into the pathological basis of such parenchymal lesions in bacterial meningitis. We reviewed clinical and imaging data (i.e., magnetic resonance tomography, magnetic resonance angiography, computed tomography angiography, digital subtraction angiography) of 68 adult patients admitted to our neurological intensive care unit between March 1998 and February 2009 with the diagnosis of community-acquired bacterial meningitis. We identified seven patients with parenchymal lesions. These lesions could be attributed to four morphological patterns: (1) territorial cerebral ischemia, (2) perforating vessels ischemia, (3) ischemia of presumed cardiac origin, and (4) isolated cortical lesions. Whereas the patterns (1) and (2) were associated with vasculopathy of large- and medium-sized vessels (as shown by cerebral vascular imaging), vessel imaging in (3) and (4) did not show abnormal findings. Our study implies that parenchymal lesions in acute bacterial meningitis are mainly ischemic and due to involvement of large-, medium-, and small-sized arteries of the brain. Diffusion-weighted imaging combined with conventional, CT-, or MR-based cerebral angiography revealed the underlying pathophysiological mechanisms in the majority of patients. Furthermore, we detected two patients with isolated bilateral cortical involvement and normal vessel imaging. These lesions might represent ischemia due to the involvement of small pial and intracortical arteries. (orig.)

  6. Extra gonadal germ cell tumors. Clinico pathologic findings, staging and treatment experience in 14 patients

    Energy Technology Data Exchange (ETDEWEB)

    Berkmen, F.; Peker, F.; Ayyildiz, A.; Basay, S.; Arik, A.I.; Ugur, I. [Ankara, Oncology Education and Research Hospital, Dept. of Urologic Oncology and Radiotherapy (Turkey)

    2000-09-01

    Extra gonadal germ cell tumors (EGCT) are a rare group of neoplasms histologically identical to testicular counterparts. Fourteen cases of primary mediastinal and retroperitoneal germ cell tumors were treated with chemotherapy and radiotherapy between 1987 and 1999 in Ankara Oncology Hospital. There were 9 (64%) complete remissions (CR), one (7%) partial remission (PR) and 2 (14%) stable diseases (SD). The remaining 2 patients were lost due to dissemination of disease. The median duration of response was 19 months. The modified chemotherapeutic results were similar to original doses of PVB and BEP but toxicity was less. The necessity of a uniform staging system and treatment programs are discussed.

  7. A retrospective clinico-pathological study comparing lichen planus pigmentosus with ashy dermatosis.

    Science.gov (United States)

    Cheng, Hui Mei; Chuah, Sai Yee; Gan, Emily Yiping; Jhingan, Anjali; Thng, Steven Tien Guan

    2018-04-10

    Controversy persists as to whether lichen planus pigmentosus and ashy dermatosis are separate clinical entities. This study was conducted to examine the clinicopathological features and treatment outcome of the two conditions. A retrospective medical chart review of all patients who were diagnosed with lichen planus pigmentosus or ashy dermatosis was conducted. The information collected included the participants' age at onset, site of onset, duration of disease, presence of precipitating factors, distribution of disease, pigmentation and presence of symptoms. In patients from whom a biopsy was taken the histopathological reports were included. Altogether 26 patients with ashy dermatosis and 29 with lichen planus pigmentosus were included in the study. Compared with ashy dermatosis, lichen planus pigmentosus had a more localised distribution with a preponderance for facial involvement, compared with the truncal preponderance in ashy dermatosis. Ashy dermatosis tended to have a more stable clinical course than lichen planus pigmentosus, which was more likely to wax and wane. The utility of histopathology in differentiating between the two conditions is low. Ashy dermatosis and lichen planus pigmentosus, as defined in this study, appear to be two separate clinical entities with distinguishable clinical features and natural histories. © 2018 The Australasian College of Dermatologists.

  8. Clinico-laboratory aspects of anti-nuclear and anti-native DNA antibody tests.

    Science.gov (United States)

    Webb, J

    1978-01-01

    Available techniques for detection of anti-nuclear antibodies are here briefly reviewed. The relatively insensitive LE cell test has been largely supplanted by the indirect immunofluorescent ANA test which should be reported in terms of titre and pattern. Specific measurement of nDNA antibodies is now a regular technique in SLE diagnosis and management.

  9. Trial production of x-ray protective coat in clinico-orthodontics and evaluation of efficiency

    International Nuclear Information System (INIS)

    Fukui, Hatsuo; Nezu, Fumio; Arita, Masatoshi; Numata, Keisuke; Nishioka, Toshio

    1977-01-01

    The authors produced for trial an x-ray protective coat for patients which could be used for any type of dental roentogenography particularly by clinicoorthodontists and could easily exert a sufficient protective effect. The trial product is of coat type covering the front, sides, and back of the trunk and is made of vinyl sheet containing lead and rubber sheet containing lead. When patients put on the coat during cephalography, the internally absorbed dose was decreased greatly in the back corresponding to the 7th cervical vertebra and the area of thyroid and considerably in the area of right joint and the area corresponding to the center of the sternal shaft. The protective effect of the coat was also great in ortho-pantomography in regions corresponding to hemopoietic tissues abundant in bone-marrow, such as the areas of bilateral joints the back corresponding to the 7th cervical vertebra, and the area corresponding to the center of sternal shaft. Internally absorbed doses in different regions due to various types of roentgenography were tabulated. The x-ray protective coat was described to be useful not only in orthodontics but also in roentogenography in the craniocervical region. (Chiba, N.)

  10. Cuidado clinico em enfermagem: desenvolvimento de um conceito na perspectiva de reconstrucao da pratica profissional

    Directory of Open Access Journals (Sweden)

    Lia Carneiro Silveira

    2013-09-01

    Full Text Available A Enfermagem é uma práxis que tem se definido a partir de diferentes planos epistemológicos. Sua historicidade é marcada por construções e desconstruções. Neste percurso, o cuidado e a sua prática clínica assumem constituições atravessadas pelos interesses sociais, econômicos e ideológicos de cada época. Objetivamos, neste texto, refletir sobre a construção do plano conceitual do cuidado clínico em enfermagem, em uma perspectiva que permita o deslocamento do modelo epistêmico tradicional pautado no referencial biomédico e no modelo cartesiano de sujeito. Trata-se de uma reflexão teórica em que desenvolvemos este conceito, partindo das concepções adotadas nas linhas de pesquisa do Mestrado Acadêmico em Cuidados Clínicos em Saúde da Universidade Estadual do Ceará. Finalizamos com a apresentação da proposta do Mestrado Acadêmico em Cuidados Clínicos da Universidade Estadual do Ceará, exemplificando como este conceito tem sido potencializador de suas produções na área da saúde e da enfermagem.

  11. Clinico-pathological study of glomerular diseases in patients with significant proteinuria in North India

    Directory of Open Access Journals (Sweden)

    Irneet Mundi

    2014-01-01

    Full Text Available Proteinuria is a common manifestation of renal disease. The present study was carried out to analyze the clinic-pathological correlation, assess the value of histopathology and immunofluorescence (IF as well as note the spectrum of renal diseases in patients with significant proteinuria. Fifty consecutive patients having proteinuria >1 g/24 h underwent ultrasound-guided percutaneous renal biopsy. Clinical information was correlated with the pathological findings and the results were analyzed. The patients were in the age range of 12-79 years. Males (60% outnumbered females (40% in all the disease categories except lupus nephritis and IgA nephropathy. The most common clinical presentation was the nephrotic syndrome, seen in 31 cases (62%. Primary glomerular diseases (72% were more common than secondary glomerular diseases (24% and tubulointerstitial diseases (4%. Overall, the most common pathological diag-nosis was focal and segmental glomerulosclerosis (FSGS (20%, followed by membranous glomerulonephritis (MGN (18%. In young patients (age 60 years it was FSGS (60%. IF modified the diagnosis in 12% of the cases. The concordance between clinical diagnosis and pathological diagnosis was 66%. The difference between clinical diagnosis and final diagnosis was statistically significant. Our study further reinforces the knowledge that renal biopsy helps in accurate diagnosis and, thus, helps in appropriate management of the patients. IF provides additional information that can make the morphologic diagnosis considerably more precise.

  12. ROLE OF MRI IN WHITE MATTER DISEASES- CLINICO-RADIOLOGICAL CORRELATION

    Directory of Open Access Journals (Sweden)

    Ravindranath Reddy Kamireddy

    2017-11-01

    Full Text Available BACKGROUND The diagnostic process is difficult as there are many different white matter disorders (inherited and acquired. MRI has high diagnostic specificity to study the pattern of brain structures. MRI is more useful in demonstrating abnormalities of myelination. MATERIALS AND METHODS Our study developed a practical algorithm that relies mainly on the characteristics of brain MRI. Our study included clinicallysuspected patients with demyelination during a period of one year. RESULTS Our study included 25 clinically-suspected patients (out of total of 400 patients with demyelination during a period of one year (February 2016 to January 2017.  Multiple sclerosis accounted for the majority of cases (36.0% followed by acute disseminated encephalomyelitis (20%.  In multiple sclerosis, majority of the patients presented in the third decade of life with a definite female preponderance (M:F-1:2.  The most common symptom and site of involvement were visual impairment (73.3% and periventricular area (80%, respectively.  Other causes like PML, PVL, CPM, reversible posterior leucoencephalopathy, leukodystrophies and motor neuron disease comprised the remainder of the cases. CONCLUSION MRI due to its excellent grey white matter resolution is very sensitive in detecting subtle demyelination, the sensitivity being still further enhanced by FLAIR sequences. MRI in correlation with the clinical signs and symptoms is an ideal modality in early diagnosis of white matter diseases.

  13. Abnormal neuronal migration: radiologic-clinic study. Alteraciones en la migracion neural: estudio clinico-radiologico

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Fernandez, M.; Menor Serrano, F.; Bordon Ferre, F.; Garcia Tena, J.; Esteban Hernandez, E.; Sanguesa Nebot, C.; Marti Bonnati, L. (Hospital Infantil La Fe, Valencia (Spain))

    1994-01-01

    We present our experience in 18 pediatric patients with abnormal neuronal migration. Seven cases of heterotopia of the gray matter, 7 agyria-pachygyria complexes, 1 case of polymicrogyria, 2 cases of schizencephaly and 1 case of hemimegalencephaly were diagnosed by means of ultrasonography, computed tomography and magnetic resonance. The clinical picture was reviewed in each case, with special attention to the occurrence of convulsions, psycho motor development and visual changes. In general, the greater the morphological change, the greater the neurological involvement in these patients. However, the two cases of schizencephaly presented mild clinical expression. Magnetic resonance increases the diagnostic yield in neuronal migration disorders. Nevertheless, either ultrasonography or, especially, computed tomography is useful as a first diagnostic approach in these malformative disorders. (Author)

  14. Clinico-radiological spectrum in enterovirus 71 infection involving the central nervous system in children.

    Science.gov (United States)

    Lee, Kyung Yeon; Lee, Yun-Jin; Kim, Tae Hyoung; Cheon, Doo-Sung; Nam, Sang-Ook

    2014-03-01

    Enterovirus 71 infection causes hand, foot and mouth disease in children, and can produce diverse neurologic complications. Epidemics occurring in Korea between 2009 and 2012 resulted in the death of some patients. The present study aimed to clarify the correlation between clinical features and MRI findings in patients presenting with acute neurologic manifestations related to enterovirus 71 infection. Based on their clinical features, the patients were classified into four clinical groups: (1) brainstem encephalitis (n=17), characterized by myoclonus, tremor, ataxia, and autonomic dysregulation such as pulmonary hemorrhage; (2) aseptic meningitis (n=2); (3) encephalitis (n=2), characterized by decreased consciousness, seizure, and fever without myoclonus, tremor, ataxia, and autonomic dysregulation; and (4) acute flaccid paralysis (n=1). Thirteen of the 17 patients with brainstem encephalitis showed characteristic lesions in the dorsal brainstem and bilateral cerebellar dentate nuclei on brain MRI, whereas three had no abnormality. One of the two patients with meningitis had a small lesion in the left dorsal pons. Two patients with encephalitis had no apparent MRI abnormality. One patient with acute flaccid paralysis of the right leg had contrast-enhancement of the bilateral ventral nerve roots at the lumbar spine level on MRI. Five of 13 patients with lesions in the bilateral dentate nuclei of the cerebellum exhibited no cerebellar symptoms, while two with no cerebellar lesions developed ataxia. Although most patients presenting with neurologic manifestations of enterovirus 71 infection had characteristic clinical features together with typical MRI findings, the clinical features were not necessarily consistent with MRI findings. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Comparison of Clinical and Laboratory Responses in Sheep and Dogs following Whole-Body Exposures to 250-Kvp X-Rays and Fission-Spectrum Neutrons; Etude Comparee Clinique et en Laboratoire, des Reactions de Moutons et de Chiens a la Suite d'une Exposition du Corps Entier a des Rayons X de 250 Kv-Crete et a des Neutrons de Fission; Sravnenie klinicheskikh i laboratornykh dannykh o reaktsii ovets i sobak na obluchenie vsego tela rentgenovskimi luchami pri pikovom napryazhenii 250 Kv i nejtronami spektra deleniya; Estudio Comparado, Clinico y de Laboratorio, de las Reacciones de Ovejas y Perros Consecutivas a la Irradiacion del Cuerpo Entero con Rayos X de 250 KVp y Neutrones de Fision

    Energy Technology Data Exchange (ETDEWEB)

    Quaife, M. A.; Boer, J. de; Jones, R. K.; Ichiki, A. T.; Godden, W. R.; Davis, H.; Engel, R. E. [Kirtland AFB, New Mexico (United States)

    1964-05-15

    parametro de la hematopoyesis con fines diagnosticos. Las alteraciones patologicas mas significativas se circunscribieron a los pulmones, donde se observaron extensas hemorragias perivasculares. Mediante el microscopio se confirmo que la zona hemorragica estaba situada entre el tejido conjuntivo adventicio y los vasos periarteriales. El indice de mortalidad a los 30 dias, en los perros, fue del 50% despues de la exposicion a los neutrones y del 93% despues de la exposicion a los iayos X. En cuanto a las ovejas, los neutrones ocasionaron una mortalidad de 22% y los rayos X, una de 80%. (author) [Russian] Pjatnadcat' ovec i vosem' sobak byli oblucheny dozoj 400 rad (vozdushnaja doza) pul'sirujushhih nejtronov spektra delenija, a takoe zhe kolichestvo ovec i 14 sobak -dozoj 400 rentgen (sredinnaja vozdushnaja doza) rentgenovskih luchej pri pikovom naprjazhenii 250 kv. Sem' ovec i chetyre sobaki byli ostavleny neobluchennymi dlja kontrolja. Kontrol'nye dannye poluchali v techenie dvuh nedel', predshestvovavshih oblucheniju, a takzhe reguljarno i chasto posle n ego . U ovec naibolee opredelennym klinicheskim izmeneniem bylo polnoe vypadenie shersti k 51 dnju posle obluchenija. Obnazhivshajasja kozha byla rozovogo cveta, ochen' napominajushhego slabyj rumjanec. U sobak vypadenija shersti ne bylo. Posle obluchenija u oboih vidov zhivotnyh rezko upalo soderzhanie formennyh jelementov krovi, nejtrofil'nyh lejkocitov, limfocitov i trombocitov. Primerno na 24-j den' posle obluchenija vosstanovlenie kolichestva lejkocitov bylo otmecheno to l'ko u zhivotnyh, podvergshihsja oblucheniju nejtronami. Urovni trombocitov snizilis' do bezopasno go urovnja u oboih vidov zhivotnyh, no u sobak jeto proizoshlo neskol'ko ran'she. Vosstanovlenie nastupilo na tret'ej nedele posle obluchenija u oboih vidov zhivotnyh, podvergshihsja oblucheniju nejtronami, no ne proizoshlo u zhivotnyh, obluchennyh rentgenovskimi luchami. Issledovanija gematokrita pokazali znachitel'noe sokrashhenie gemoglobina u oboih

  16. Videoendoscopic and histological characterization of patients with colorectal cancer in the Teaching Clinico-surgical Hospital Comandante 'Faustino Perez Hernandez'; Caracterizacion videoendoscopica e histologica de pacientes con cancer colorrectal en el Hospital Universitario Clinico Quirurgico Comandante 'Faustino Perez Hernandez'

    Energy Technology Data Exchange (ETDEWEB)

    Avalos Garcia, Roxana; Ramos Pachon, Carlos Manuel; Barbon Abreu, Mercedes, E-mail: roxyavalos.mtz@infomed.sld.cu [Hospital Universitario Clinico Quirurgico Comandante ' Faustino Perez Hernandez' , Matanzas (Cuba)

    2013-07-01

    In Cuba, colorectal cancer is the third cause of mortality after lung and prostate cancer. We developed our work with the objective of arriving to an endoscopic and histological characterization of the patients with colorectal cancer diagnosed in the mentioned hospital.

  17. A clinico-radiologic study of the various lesions in the oral and maxillofacial region of children

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Soon Chul; Lee, Young Ho; Park, Tae Won; You, Dong Soo [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1995-08-15

    Two thousand-two hundred-forty-three cases of various lesions of the oral and maxillofacial region in children under 16 years of age were reviewed. The lesions were classified by 10 groups, osteomyelitis, cysts, benign tumors, malignant tumors, fibro-osseous lesions, developmental disturbances, antral lesions, TMJ lesions, salivary gland lesions, and other lesions. The obtained results were as follows; 1. Developmental disturbances, especially cleft alveolus and palate, was the most common lesions (25.7%), followed by cysts (22.5%), antral lesions (12.7%), benign tumors (11.9%) and osteomyelitis (9.3%). 2. With the time, the incidence of osteomyelitis and malignant tumors has been decreased, but that of developmental disturbances, cysts and antral lesions has been increased. 3. The sex distribution was relatively equal for the entire series, with male predominence in cysts, malignant tumors, developmental disturbances and salivary gland lesions and with female predominance in TMJ lesions. 4. Children with malignant tumors and osteomyelitis were somewhat younger and those with TMJ lesions were somewhat older. 5. Heading the list of each group except osteomyelitis was dentigerous cyst, odontoma, malignant lymphoma, fibrous dysplasia, cleft alveolus and palate, inflammatory change, degenerative change of condylar process, sialolithiasis and simple bone cyst respectively.

  18. Arsenic induced clinico-hemato-pathological alterations in broilers and its attenuation by vitamin e and selenium

    International Nuclear Information System (INIS)

    Mashkoor, J.; Khan, A.; Khan, M.Z.; Saleemi, M.K.; Mahmood, F.

    2012-01-01

    Present study was carried out to know the arsenic (As) induced toxico-pathological alterations in broiler chicks and their attenuation with vitamin E (Vit E) and selenium (Se). A total of 90 day-old broiler chicks were equally distributed into 5 groups. Groups 1-4 were administered As at 50 mg/kg BW daily through feed for 30 days. In addition to A , groups 2 to 4 received Vitamin E at 150 mg/kg BW, selenium at 0.25 mg/kg BW and Vitamin E plus selenium, respectively. Group 5 (Control) received normal drinking water for 30 days. Dullness, depression, open mouth breathing, increased thirst; ruffled feathers, pale comb, skin irritation and watery diarrhea were the most striking clinical signs. The body weight and feed intake was significantly decreased in treated birds. The erythrocyte counts, hemoglobin concentration and packed cell volume decreased (P<0.05) in treated broilers with As or As with Se and Vit E. Grossly pale and hemorrhagic liver and swollen kidneys were observed in As treated birds. Arsenic treated groups showed significant decrease in serum. Histopathologically, liver exhibited congestion and cytoplasmic vacuolation. In kidneys, condensation of tubular epithelium nuclei, epithelial cell necrosis, increased urinary spaces, sloughing of tubules from basement membrane and cast deposition were observed. In conclusion As induced toxico-pathological alterations and vitamin E and selenium partially ameliorate the toxic effects in broilers chicks. (author)

  19. A CLINICO-EPIDEMIOLOGICAL STUDY OF INFERTILE COUPLES AMONG THE SUBURBAN/RURAL POPULATION OF BOKAKHAT, ASSAM

    OpenAIRE

    Pranabika

    2016-01-01

    Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse (WHO-ICMART). Infertility is the inability of a sexually active, non-contraception couple to achieve pregnancy in one year. Infertility affects relatively large number of couples, both globally as well as in India. There are sparse data on the prevalence of infertility in India. This study describes the correla...

  20. The efficacy of a herbal-based toothpaste in the control of plaque and gingivitis: A clinico-biochemical study

    Directory of Open Access Journals (Sweden)

    George Jacob

    2009-01-01

    Full Text Available Objective: A double-blinded controlled clinical trial with parallel groups was designed to investigate the effectiveness of a herbal-based toothpaste in the control of plaque and gingivitis as compared with a conventional dentifrice. The efficacy of Colgate Herbal over Colgate tooth paste was assessed in this study. Materials and Methods: Thirty subjects with gingivitis participated in the study. All participants had at least 20 natural teeth with no probing depths greater than 3 mm and a plaque index score of 2 or more at baseline. At baseline, the clinical parameters like gingival index, plaque index and salivary pH were estimated. Paired t-test was used to compare the difference within the groups and unpaired t-test was used to compare the difference between the groups at baseline and on the 30 th day. Results: At the end of the study, there were statistically significant reductions in the gingival index and the plaque index scores within the test group. However, there were no statistically significant differences between the test and the control groups. The salivary pH changes were not statistically significant in the test group but were displaced more toward the acidic range in the control group. Conclusion: It was however concluded that the herbal-based toothpaste was as effective as the conventionally formulated dentifrice in the control of plaque and gingivitis.

  1. Study of the leakage current of clinical dosimeters for teletherapy; Estudo da corrente de fuga de dosimetros clinicos para teleterapia

    Energy Technology Data Exchange (ETDEWEB)

    Damatto, Willian B.; Santos, Gelson P.; Potiens, Maria da Penha A.; Caldas, Linda V.E.; Vivolo, Vitor, E-mail: wbdamatto@ipen.b, E-mail: gpsantos@ipen.b, E-mail: mppalbu@ipen.b, E-mail: lcaldas@ipen.b, E-mail: vivolo@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2009-07-01

    This work demonstrates the importance of quality control of clinical dosemeters and therefore the equipment for radiotherapy treatment, exhibiting the necessary care related to answers and sensibilities and the possible defects of the clinical assembly

  2. Effects of meldonium on cognitive and clinico-functional status of elderly patients with acute myocardial infarction and arterial hypertension

    Directory of Open Access Journals (Sweden)

    Dotsenko N.J.

    2013-03-01

    Full Text Available 40 elderly patients with a diagnosis of acute myocardial infarction developed on the background of arterial hypertension were examined. The patients were divided into two groups: the main – 20 patients (18 men, 2 women, age 70.0 ± 1.8 years, and the control group – 20 patients (19 men, 1 woman, age 69.5 ± 1.6 years, who received the standard treatment of acute myocardial infarction and hypertension. "Standard therapy" included acetylsalicylic acid and clopidogrel, statins, beta-blockers and ACE inhi¬bitors, if necessary, drugs to control hypertension, according to the recom¬mendations of the Ukrainian Society of Cardiologists. In addition, the first group of patients undergoing standard therapy of AMI and hypertension was administered Vazonat® for 15 days intravenously at a dose of 1000 mg per day. Effect of Vazonat® (meldonium therapy on the clinical and functional status, exercise capacity, and cognitive status in patients with acute myocardial infarction and hypertension against the background of dyscirculatory encephalopathy was studied explored. Psycho-emotional state of patients was studied by Beck's depression scale. Cognitive status was assessed by neuropsychological tests (Schulte tables, Luria’s test for memorizing of 10 words and Luria’s pictograms. In was shown dynamics a positive effects of Vazonat® therapy on the improvement of cardio¬hemo¬dynamics (noted reduction in LVED with 55.20 ± 1.7 mm to 51.28 ± 1.5 mm (p > 0.1, an increasing transmitral flow Ve/Va from 0.98 ± 0.03 to 1.10 ± 0.04 (p < 0.05, an increasing exercise tolerance (at 6MWT distance increased by 12.8% in the main group (from 289.6 ± 12.2 m to 326.0 ± 13.5 m, an increasing the speed of active attention – time of sensorimotor reactions decreased from 68.55 ± 6.2 sec to 54.35 ± 3.52 sec (p < 0.05, increasing productivity of short-term memory, increasing the number of words in the Luria test from 5.90 ± 0.42 to 7.25 ± 0.38 (p < 0.05, moderate antidepressant effects and the ability to improve overall health in this group of patients compared with the control group. Good tolerance and safety of Vazonat® was proven. Studies presented show multiple propertics of the pharmacodynamics of Vazonat®. The unique properties of Vazonat® as a universal cytoprotector are the basis of its ability to improve outcomes after myocardial infarction in elderly persons after stabilization and selection of basic therapy.

  3. PET, Positron emission tomography: Presentation of a clinical case; PET, Tomografia por emision de positrones: Presentacion de un caso clinico

    Energy Technology Data Exchange (ETDEWEB)

    Sierralta C, Paulina; Jofre M, M Josefina; Gonzalez E, Patricio; Massardo V, Teresa; Humeres A, Pamela; Canessa G, Jose [Hospital Militar de Santiago, Servicio de Medicina Nuclear, Centro PET de Imagenes Moleculares, Santiago (Chile)

    2003-07-01

    A patient with a solitary pulmonary nodule is presented. She was studied with PET using F-18 FDG. The metabolic images demonstrated increased uptake in the nodule and 2 additional areas suggestive of extension, not seen in anatomic diagnostic procedures. These findings were compatible with a malignant tumour with metastasis (au)

  4. [Clinico-organizational and certain deontological aspects (defects) of medical care for patients with severe community-acquired pneumonia].

    Science.gov (United States)

    Dimov, A S; Volkova, O A; Maksimov, N I

    2008-01-01

    Objective causes of fatal extramural pneumonia, such as social factors and the severity of the disease, should be considered along with subjective medical errors. Clinical and deontological analysis of lethal cases revealed a number of defects in providing medical care for such patients especially in terms of correction of cardiovascular disorders. Special analysis of 51 medical histories from the ethical viewpoint indicated that 4/5 of the patients had good reasons to set up deontological claims against their doctors.

  5. A clinico-biochemical evaluation of the role of a herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study.

    Science.gov (United States)

    Shetty, Shreya; Bose, Aditi; Sridharan, Srirangarajan; Satyanarayana, Aparna; Rahul, Aparna

    2013-06-01

    Host modulation is fast gaining popularity as a preferred therapeutic modality for periodontal disease. Recent research in the medical field into herbal immunomodulators such as Septilin® has spurred an interest in evaluating its efficacy in periodontitis for the first time. The aim of the study was to assess the immunomodulatory effects of the herbal immunomodulator Septilin® (Himalaya Drug Company, Bangalore, India) when used as an adjunct to scaling and root planing in chronic periodontal disease. Forty systemically healthy patients aged between 25 and 55 years of age and with chronic periodontitis were randomly divided into two groups. The test group was administered Septilin® tablets for two weeks following scaling and root planing whereas the control group was treated by scaling and root planing alone. Changes in gingival index (GI), gingival bleeding index (GBI), serum C-reactive protein (CRP) levels and salivary tumour necrosis factor-alpha (TNF-α) levels were assessed at day 0, at two weeks, and at three and six months. The GI and GBI showed a statistically significant reduction at two weeks, three months and six months (P0.05). In this pilot evaluation, Septilin® was found to be a safe and effective immunomodulator as an adjunct to routine periodontal therapy. Further long-term studies to test Septilin® on larger sections of the population are recommended.

  6. Evaluation of C-Reactive Protein and Fibrinogen in Patients with Chronic and Aggressive Periodontitis: A Clinico-Biochemical Study.

    Science.gov (United States)

    Chandy, Swaroop; Joseph, Kiran; Sankaranarayanan, Anila; Issac, Annie; Babu, George; Wilson, Bobby; Joseph, Jumol

    2017-03-01

    Periodontal disease is characterised by chronic infection and inflammation in periodontal tissues leading to destruction of alveolar bone with subsequent tooth loss. Periodontal infections are the result of an interaction between tooth associated microbial biofilms and the host defences. Periodontal pathogens can affect local and systemic immune and inflammatory responses. The aim of the present study was to evaluate serum C-Reactive Protein (CRP), plasma fibrinogen and peripheral blood levels in healthy subjects, chronic and aggressive periodontitis patients. A total of 55 subjects, 27 males and 28 females were selected for the study. Blood samples were taken from healthy controls (n=20) and patients with chronic periodontitis (n=20) and aggressive periodontitis (n=15). The periodontal status of each patient was assessed by recording Oral Hygiene Index-Simplified (OHI-S), Bleeding Index (BI), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL). The levels of serum CRP were measured using high sensitivity Enzyme Linked Immunosorbent Assay (ELISA) and levels of plasma fibrinogen were measured using Quantitative Immunoturbidimetric assay. Data description was done in the form of mean and standard deviation and analysis of data was done using one way ANOVA (Analysis of Variance) and Students t-test to test the statistical significance between groups. The levels of serum CRP and plasma fibrinogen was increased in patients with chronic and aggressive periodontitis when compared to healthy controls (pperiodontitis and cardiovascular diseases.

  7. Clinico-biochemical factors to early predict biliary etiology of acute pancreatitis: age, female gender, and ALT.

    Science.gov (United States)

    Zarnescu, N O; Costea, R; Zarnescu Vasiliu, E C; Neagu, S

    2015-01-01

    Background/ Aims: Despite the existence of an easy tool to diagnose biliary tract disease as an etiology for acute pancreatitis (AP), the sensitivity of abdominal ultrasound is around 80%, which can be even lower in certain conditions. We have retrospectively reviewed data of 146 patients admitted for acute pancreatitis between 1999 and 2013. Bivariate analysis for clinical and biochemical variables was performed with respect to etiology of AP (biliary versus non-biliary). Multivariate analysis was performed by using binary logistic regression. There were 87 males (59.6%) and 59 females (40.4%), with a median age of 51. The etiology of acute pancreatitis was biliary in 71 patients (48.6%). Bivariate analysis found the following as significant association (p=0.001) with biliary pancreatitis: older age, female gender, and elevated AST, ALT. A binary logistic regression analysis identified as predictor factors for biliary etiology of acute pancreatitis: age OR = 1.031 (95% CI 1.004 - 1.059, p = 0.024), sex (female) OR = 2.34 (95% CI 1.022 - 5.359, p = 0.044) and ALT OR = 1.004 (95% CI 1.001 - 1.007, p =0.004). The two clinical scores included the three variables (A.S.ALT scores) in categorical format were generated and then checked with the ROC curves (areas under curve are 0.768 and 0.778). Age, female gender, and elevated ALT can help identifying cases with biliary etiology of acute pancreatitis.

  8. A study on the etiological agent and clinico-mycological correlation of fingernail onychomycosis in eastern India

    Directory of Open Access Journals (Sweden)

    Das Nilay

    2008-01-01

    Full Text Available Background: Onychomycosis manifests itself in various forms, notably onychodystrophy, onycholysis, subungual hyperkeratosis, or nail-plate discoloration. Not necessarily nail changes mentioned here should always be of fungal origin. Objective: The present study is planned to get an idea about etiological agent and clinical correlation in fingernail onychomycosis. Materials and Methods: Nail-clipping and subungual debris of patients with above mentioned nail changes were subjected to KOH preparation. Culture was done on SDA and SDCCA media. Species identification was done by colony character, pigment production, LCB staining, and some special tests like germ tube test, etc. Results: Out of 85 cases, 44 cases showed the growth of fungus, amounting to 51.76% positivity. Among those 44 cases, the infective fungal agents were predominantly dermatophytes (50%, and the rest were due to yeasts (27.27% and moulds (22.72%. Among the different species, Trichophyton rubrum (29.54% accounted for the majority of dermatophytes; Candida albicans (11.78% was the predominant yeast; and Aspergillus niger (18.18% the commonest mold. No significant association could be established between the different fungal species and various clinical manifestations. Positive results were found more with fungal culture (95.45% than KOH preparation (63.64%. Conclusion: The results show that nail changes are not always a reliable marker for predicting the causative organism, and relying only on the clinical manifestation (i.e., pattern of nail changes in the diagnosis of onychomycosis is often misleading. The present study highlights the need for microbiological confirmation in case of onychomycosis.

  9. Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors

    International Nuclear Information System (INIS)

    Klajic, Jovana; Tost, Jörg; Kristensen, Vessela N; Fleischer, Thomas; Dejeux, Emelyne; Edvardsen, Hege; Warnberg, Fredrik; Bukholm, Ida; Lønning, Per Eystein; Solvang, Hiroko; Børresen-Dale, Anne-Lise

    2013-01-01

    Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylation patterns in order to identify valuable markers to understand how these changes affect breast cancer progression. Quantitative DNA methylation analyses of 12 candidate genes ABCB1, BRCCA1, CDKN2A, ESR1, GSTP1, IGF2, MGMT, HMLH1, PPP2R2B, PTEN, RASSF1A and FOXC1 was performed by pyrosequencing a series of 238 breast cancer tissue samples from DCIS to invasive tumors stage I to IV. Significant differences in methylation levels between the DCIS and invasive stage II tumors were observed for six genes RASSF1A, CDKN2A, MGMT, ABCB1, GSTP1 and FOXC1. RASSF1A, ABCB1 and GSTP1 showed significantly higher methylation levels in late stage compared to the early stage breast carcinoma. Z-score analysis revealed significantly lower methylation levels in DCIS and stage I tumors compared with stage II, III and IV tumors. Methylation levels of PTEN, PPP2R2B, FOXC1, ABCB1 and BRCA1 were lower in tumors harboring TP53 mutations then in tumors with wild type TP53. Z-score analysis showed that TP53 mutated tumors had significantly lower overall methylation levels compared to tumors with wild type TP53. Methylation levels of RASSF1A, PPP2R2B, GSTP1 and FOXC1 were higher in ER positive vs. ER negative tumors and methylation levels of PTEN and CDKN2A were higher in HER2 positive vs. HER2 negative tumors. Z-score analysis also showed that HER2 positive tumors had significantly higher z-scores of methylation compared to the HER2 negative tumors. Univariate survival analysis identifies methylation status of PPP2R2B as significant predictor of overall survival and breast cancer specific survival. In the present study we report that the level of aberrant DNA methylation is higher in late stage compared with early stage of invasive breast cancers and DCIS for genes mentioned above

  10. Clinico-pathological profile and treatment outcome in smear negative pulmonary tuberculosis patients at a teaching hospital

    International Nuclear Information System (INIS)

    Shabir, I.; Iqbal, R.; Khan, S.U.; Munir, K.; Nazir, A.

    2010-01-01

    Tuberculosis remains the single highest contributor to the world's morbidity and mortality. Early diagnosis and prompt treatment is essential to prevent its transmission. To see the treatment response of anti tuberculosis drugs in smear negative patients and study the predictors of culture positive among smear negative tuberculosis patients. Ninety four sputum smear negative patients clinically and radiologically suggestive of tuberculosis were selected. These patients were put on anti tuberculosis drugs without waiting for their culture results. They were then followed for 8 months to see their treatment outcome. A total of 94 smear negative patients were selected and given anti tuberculosis treatment. Of these 37(39%) were culture positive and 57(61%) were culture negative. Of the 37 culture positive patients 36(97%) showed clinical or radiological improvement as compared to 46(81%) out of 57 in culture negative cases. Symptoms of cough with sputum production was significantly associated with culture positivity. On x-ray chest moderate lesion with diffuse infiltration was more common finding in 64% while extensive and cavitatory lesion was seen in 24% of all cases. Association of extensive and cavitatory lesion were seen in culture positive group. Response to anti tuberculosis drugs in sputum smear negative tubercolosis suspects was found to be effective in majority of the patients. Cough, sputum and extensive cavitatory lung lesion were the predictors of culture positive cases. There is need to train physicians on the use of anti tuberculosis therapy in smear negative suspected pulmonary tuberculosis cases, especially if they have productive cough and cavitatory lung lesions. (author)

  11. CLINICO - EPIDEMIOLOGICAL STUDY AND TREATMENT OUTCOME OF EALES’ DISEASE AT A TERTIARY EYE CARE HOSPITAL IN EASTERN INDIA

    Directory of Open Access Journals (Sweden)

    Bijnya Birajita

    2015-09-01

    Full Text Available BACKGROUND: Eales’ disease is an idiopathic inflammatory venous occlusion that primarily affects the peripheral retina of adults. Retinal changes include perivascular phlebitis, peripheral non - perfusion, and neovascularization. The prese nt - day modalities of treatment are confined to corticosteroids, anti - VEGF (Vasculo - endothelial growth factor therapy, and photocoagulation with or without anterior retinal cryoablation, and vitrectomy at various stages of the disease process. AIM : This study was conducted to study the age and sex distribution along with the mode of presentation of Eales disease. The natural course, aetiopathogenesis, treatment outcome in the study population was also studied. MATERIAL AND METHODS: In this descriptiv e study, 63 eyes of 37 newly diagnosed cases of Eales disease were enrolled. The demographic profile and clinical parameters of each patient were studied with special reference to place of origin, age and sex, mode of presentation, and treatment outcome. A ll patients underwent complete systemic and ophthalmologic examinations. Study patients were classified according to the stage of their disease and treated accordingly. RESULTS: Young males (21 - 30 years were mostly affected and 70% had bilateral presentat ion. 61% presented with symptoms related to posterior segment disease. Recorded best corrected visual acuity were 6/6 - 6/12 in 44.5%, 6/12 - 6/60 in 20% and <6/60 in 36.5%. 2 patients were kept on observation, 17 with medical treatment alone, 10 with photocoa gulation alone, 3 with photocoagulation and medical treatment and 5 were taken for vitreo - retinal surgery. Good visual recovery was observed in all subgroups at subsequent follow - up visits. CONCLUSION: As noted by this study, Eales disease is a disease mos tly in the young. These patients can present with no typical symptom or can be asymptomatic. Staging of the disease at presentation is important and correct treatment options should be given in order to achieve good visual outcomes

  12. Clinicoepidemiologic characterization and endoscopy in patients with colorectal cancer; Caracterizacion clinico-epidemiologica y endoscopica en pacientes con cancer colorrectal

    Energy Technology Data Exchange (ETDEWEB)

    Hano Garcia, Olga Marina; Wood Rodriguez, Lisette; Villa Jimenez, Oscar Manuel, E-mail: olga.hano@infomed.sld.c [Instituto Nacional de Gastroenterologia, La Habana (Cuba)

    2010-07-01

    Colorectal carcinoma is recognized as the second death cause from cancer in most of developed countries; the increasing exposure to risk factor such as smoking, changes in diet, in lifestyles, as well as environmental and infectious factors is conductive to its morbidity and mortality increase. A prospective and descriptive study was conducted in 65 patients older than 18 years seen from April, 2007 to April, 2008 in the Endoscopy Service of the National Institute of Gastroenterology, diagnosed with colorectal carcinoma by colonoscopy and histology. In collection form were registered: sex, age, personal backgrounds of colon cancer, polyps, intestinal inflammatory disease and cholecystectomy; family backgrounds of colon cancer or another location; toxic habits: smoking and alcoholism; diet as regards: vegetal fiber ingestion and animal fat; anatomic location of cancer and histology. We conclude that there was predominance of female sex, the more frequent diagnosis age was between 60 and 70 years. The personal background of colon polyp and the family background of colon cancer were the more frequent. There was also predominance of smokers and heavy drinkers with or without effect. There was a great ingestion of animal fat and few ingestion of vegetal fiber. The more frequent anatomical location was the rectosygmoid, where the histological colon adenocarcinoma had the greater frequency

  13. Clinic-surgical characterization of the colorectal cancer in inpatients;Caracterizacion clinico quirurgica del cancer colorrectal en pacientes ingresados

    Energy Technology Data Exchange (ETDEWEB)

    Alejo Concepcion, Osvaldo; Castillo Lamas, Libardo; Umpierrez Garcia, Ibis [Hospital Militar Docente ' Dr Mario Munnoz Monroy' , Matanzas (Cuba)

    2009-07-01

    The colorectal cancer presents high incidence. This pathology occupies the fifth place among the neoplasias in both sexes in Cuba. With the objective of characterizing this disease we carried out a descriptive transversal study at the service of General Surgery of the University Military Hospital of Matanzas 'Dr. Mario Munnoz Monroy', in the period from January 2001 to January 2005, studying age, sex, familiar oncological antecedents, presentation form, localization and diagnosis of the tumor, and also the surgical technique used in the treatment. The results showed predominance of the male sex in ages between 60 and 69 years old, different symptoms depending on the localization, predominance of the rectal cancer, and others. It was concluded that there is a delay between the beginning of the symptoms and the diagnosis, considerably diminishing the healing possibilities and survival

  14. Polineuropatia por Parathion: estudo clinico, eletrofisiológico e histológico de um caso

    Directory of Open Access Journals (Sweden)

    José L. Alonso

    1983-09-01

    Full Text Available Estudamos um paciente com quadro clínico rebelde, produzido por intoxicação pelo Parathion. Foi observado um fenômeno miotônico transitório, não descrito na literatura revisada. A constatação de cifras de AchE eritrocitária baixas e de colinesterase plasmática normais, indicou que era portador de déficit congênito de AchE, esclarecendo-se a evolução crônica do seu quadro. O fenômeno miotônico associado ao quadro clínico, eletrofisiológico, histológico e bioquímico fazem deste paciente um modelo clínico, de etiologia conhecida, da discutida síndrome de Isaacs.

  15. Clinico-morphological comparisons in ultrasound diagnosis of carcinoma of the thyroid in children exposed to radiation

    Energy Technology Data Exchange (ETDEWEB)

    Cherstvoj, E D [Minsk Medical Inst., Minsk (Belarus); Demidchik, E P [Republican Centre of Hygiene and Epidemiology, Minsk (Belarus); Drozd, V M [Scientific Research Inst. for Radiation Medicine, Belarus Ministry of Health, Minsk (Belarus)

    1997-09-01

    The purpose of the study was to compare morphologic and ultrasonic pictures of the thyroid. The study included 42 children with thyroid cancer exposed to ionizing radiation after the Chernobyl accident. All children were operated on during 1990-1994 yy. This study has shown that diffuse sclerosing variant of papillary carcinoma (PC) occurred more frequently in patients with higher absorbed doses to the thyroid. This variant of PC was rarely found at pT1 stage, besides, diffuse sclerosing PC was more frequently accompanied by bilateral and median metastases (``pure`` PC and follicular variant of PC). Biometry of thyroid carcinoma showed a wider spread of neoplastic process in diffuse sclerosing PC than in pure papillary carcinoma. The patients with diffuse sclerosing PC had the second operation more frequently than those with follicular PC. 14 refs, 5 tabs.

  16. Vivencias emocionais de mulheres submetidas a cirurgia bariatrica no Hospital de Clinicas da Unicamp : um estudo clinico-qualitativo

    OpenAIRE

    Ronis Magdaleno Junior

    2009-01-01

    Resumo: Este estudo teve por objetivo compreender as vivências emocionais de mulheres obesas mórbidas submetidas à cirurgia bariátrica. A obesidade tornou-se, globalmente, um grave problema de saúde pública e, em função disto, tem crescido de modo expressivo o número de cirurgias bariátricas como opção de tratamento para a obesidade mórbida. Contudo, é um procedimento que implica em importantes modificações físicas e psicossociais para o paciente. Metodologia: Aplicamos o Método Clínico Quali...

  17. [Clinico-electromyographic evaluation of the state of motor units of the hand muscles replanted after traumatic amputation].

    Science.gov (United States)

    Rezkov, G I

    1991-01-01

    Needle electromyography was used to study motor units of the muscles leading away the thumb and little finger, replanted after traumatic amputation of the large segment of the upper limb in 34 patients. A direct relationship was discovered between the time of the appearance of action potentials of motor units (PMU), recovery of the movements, and trauma level. The appearance of clear PMU associated with movement recovery was recorded not earlier than 6-7 months after trauma. Analysis of PMU is a reliable criterion for the recovery of the own movements of the muscles and function of the neuromotor apparatus in patients with the replanted upper limb segment.

  18. Clinico-epidemiological characteristics of acute respiratory infections caused by coronavirus OC43, NL63 and 229E.

    Science.gov (United States)

    Reina, J; López-Causapé, C; Rojo-Molinero, E; Rubio, R

    2014-12-01

    Acute respiratory infection is a very common condition in the general population. The majority of these infections are due to viruses. This study attempted to determine the clinical and epidemiological characteristics of adult patients with respiratory infection by the coronavirus OC43, NL63 and 229E. Between January 2013 and February 2014, we prospectively studied all patients with suspected clinical respiratory infection by taking throat swabs and performing a reverse transcription polymerase chain reaction in search of coronavirus. In 48 cases (7.0% of the 686 enrolled patients; 12.6% of the 381 in whom a virus was detected) the presence of a coronavirus demonstrated. In 24 cases, the virus was OC43 (50%); in 14 cases, the virus was NL63 (29%); and in 10 cases, the virus was 229E (21%). The mean age was 54.5 years, with a slight predominance of men. The most common clinical presentations were nonspecific influenza symptoms (43.7%), pneumonia (29.2%) and chronic obstructive pulmonary disease exacerbation (8.3%). Fifty-two percent of the patients required hospitalization, and 2 patients required intensive care. There were no deaths. Acute respiratory infections caused by coronavirus mainly affect middle-aged male smokers, who are often affected by previous diseases. The most common clinical picture has been nonspecific influenza symptoms. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  19. Clinico-mycological study of dermatophytic infections and their sensitivity to antifungal drugs in a tertiary care center

    Directory of Open Access Journals (Sweden)

    Soniya Mahajan

    2017-01-01

    Conclusion: Inadequate and irregular use of antifungal drugs has led to the emergence of resistant strains, which cause poor treatment outcomes. Thus, it is very important to test for antifungal sensitivity to check for resistance to antifungals.

  20. Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic study.

    Science.gov (United States)

    Iacovazzo, Donato; Caswell, Richard; Bunce, Benjamin; Jose, Sian; Yuan, Bo; Hernández-Ramírez, Laura C; Kapur, Sonal; Caimari, Francisca; Evanson, Jane; Ferraù, Francesco; Dang, Mary N; Gabrovska, Plamena; Larkin, Sarah J; Ansorge, Olaf; Rodd, Celia; Vance, Mary L; Ramírez-Renteria, Claudia; Mercado, Moisés; Goldstone, Anthony P; Buchfelder, Michael; Burren, Christine P; Gurlek, Alper; Dutta, Pinaki; Choong, Catherine S; Cheetham, Timothy; Trivellin, Giampaolo; Stratakis, Constantine A; Lopes, Maria-Beatriz; Grossman, Ashley B; Trouillas, Jacqueline; Lupski, James R; Ellard, Sian; Sampson, Julian R; Roncaroli, Federico; Korbonits, Márta

    2016-06-01

    Non-syndromic pituitary gigantism can result from AIP mutations or the recently identified Xq26.3 microduplication causing X-linked acrogigantism (XLAG). Within Xq26.3, GPR101 is believed to be the causative gene, and the c.924G > C (p.E308D) variant in this orphan G protein-coupled receptor has been suggested to play a role in the pathogenesis of acromegaly.We studied 153 patients (58 females and 95 males) with pituitary gigantism. AIP mutation-negative cases were screened for GPR101 duplication through copy number variation droplet digital PCR and high-density aCGH. The genetic, clinical and histopathological features of XLAG patients were studied in detail. 395 peripheral blood and 193 pituitary tumor DNA samples from acromegaly patients were tested for GPR101 variants.We identified 12 patients (10 females and 2 males; 7.8 %) with XLAG. In one subject, the duplicated region only contained GPR101, but not the other three genes in found to be duplicated in the previously reported patients, defining a new smallest region of overlap of duplications. While females presented with germline mutations, the two male patients harbored the mutation in a mosaic state. Nine patients had pituitary adenomas, while three had hyperplasia. The comparison of the features of XLAG, AIP-positive and GPR101&AIP-negative patients revealed significant differences in sex distribution, age at onset, height, prolactin co-secretion and histological features. The pathological features of XLAG-related adenomas were remarkably similar. These tumors had a sinusoidal and lobular architecture. Sparsely and densely granulated somatotrophs were admixed with lactotrophs; follicle-like structures and calcifications were commonly observed. Patients with sporadic of familial acromegaly did not have an increased prevalence of the c.924G > C (p.E308D) GPR101 variant compared to public databases.In conclusion, XLAG can result from germline or somatic duplication of GPR101. Duplication of GPR101 alone is sufficient for the development of XLAG, implicating it as the causative gene within the Xq26.3 region. The pathological features of XLAG-associated pituitary adenomas are typical and, together with the clinical phenotype, should prompt genetic testing.

  1. A clinico-etiological study of dermatoses in pediatric age group in tertiary health care center in South Gujarat region

    Directory of Open Access Journals (Sweden)

    Sugat A Jawade

    2015-01-01

    Full Text Available Background: Dermatologic conditions have different presentation and management in pediatric age group from that in adult; this to be studied separately for statistical and population based analysis. Objective: To study the pattern of various dermatoses in infants and children in tertiary health care center in South Gujarat region. Materials and Methods: This is a prospective study; various dermatoses were studied in pediatric patients up to 14 years of age attending the Dermatology OPD of New Civil Hospital, Surat, Gujarat over a period of 12 months from June 2009 to June 2010. All patients were divided into four different study groups: 1 to 6 years and 7 to 14 years. Results: There were 596 boys and 425 girls in total 1021 study populations. Majority of the skin conditions in neonates were erythema toxicum neonatorum (12.97%, scabies (9.92%, mongolian spot (9.16%, and seborrheic dermatitis (7.63%. In > 1 month to 14 years age group of children among infectious disorder, children were found to be affected most by scabies (24.49%, impetigo (5.96%, pyoderma (5.62%, molluscum contagiosum (5.39%, tinea capitis (4.49%, leprosy (2.02%, and viral warts (1.35% while among non-infectious disorders, they were affected by atopic dermatitis (4.27%, pityriasis alba (4.16%, seborrheic dermatitis (3.60%, pityriasis rosea (3.15%, others (3.01%, phrynoderma (2.70%, lichen planus (2.58%, contact dermatitis (1.57% and ichthyosis (1.45%. Conclusion: There is a need to emphasize on training the management of common pediatric dermatoses to dermatologists, general practitioners and pediatricians for early treatment.

  2. The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters

    Energy Technology Data Exchange (ETDEWEB)

    Al Sarakbi, W; Sasi, W [St George' s University of London, Blackshaw Road, Tooting, London, SW17 OQT (United Kingdom); Jiang, WG [University Department of Surgery, Wales College of Medicine, Cardiff University, CF14 4XN (United Kingdom); Roberts, T; Newbold, RF [Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex, UB8 3PH (United Kingdom); Mokbel, K [St George' s University of London, Blackshaw Road, Tooting, London, SW17 OQT (United Kingdom); Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex, UB8 3PH (United Kingdom)

    2009-08-21

    SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is located on the short arm of chromosome 3p and we previously demonstrated that the 3p21.31 region of chromosome 3 was associated with permanent growth arrest of breast cancer cells. This region includes closely related genes namely: MYL3, CCDC12, KIF9, KLHL18 and SETD2. Based on the biological function of these genes, SETD2 is the most likely gene to play a tumour suppressor role and explain our previous findings. Our objective was to determine, using quantitative PCR, whether the mRNA expression levels of SETD2 were consistent with a tumour suppressive function in breast cancer. This is the first study in the literature to examine the direct relationship between SETD2 and breast cancer. A total of 153 samples were analysed. The levels of transcription of SETD2 were determined using quantitative PCR and normalized against (CK19). Transcript levels within breast cancer specimens were compared to normal background tissues and analyzed against conventional pathological parameters and clinical outcome over a 10 year follow-up period. The levels of SETD2 mRNA were significantly lower in malignant samples (p = 0.0345) and decreased with increasing tumour stage. SETD2 expression levels were significantly lower in samples from patients who developed metastasis, local recurrence, or died of breast cancer when compared to those who were disease free for > 10 years (p = 0.041). This study demonstrates a compelling trend for SETD2 transcription levels to be lower in cancerous tissues and in patients who developed progressive disease. These findings are consistent with a possible tumour suppressor function of this gene in breast cancer.

  3. Clinico-mycological and Antifungal Susceptibility Profiles of Candiduria in A Tertiary Care Hospital From South India

    Directory of Open Access Journals (Sweden)

    Dinoop Korol Ponnambath

    2017-10-01

    Full Text Available Introduction: Candida is one of the common causative agent of Urinary Tract Infections (UTI worldwide. The most common reported species causing UTI is Candida albicans. Incidence of UTI due to non-albicans Candida species. is on rise in recent years because of their better adaptability and increased resistance to antifungals. Susceptibility profile reports of various Candida species. to newer azoles like voriconazole and betaglucan inhibitors (e.g., caspofungin are deficient in India, since the reference broth microdilution method is not widely utilized. In this study, a rapid reliable and easier alternative, VITEK 2 compact system was utilized to determine the antifungal susceptibility profile. Aim: To analyse the clinical and mycological profile with determination of drug susceptibility pattern of Candida isolates from urine samples. Materials and Methods: This observational study was conducted in PSG Institute of Medical Sciences and Research, during April to September 2015. Candida isolated with a colony count of ≥103 CFU/ml of urine from clinically suspected cases of UTI were included in the study. Urine samples (n=3821 from clinically suspected UTI cases (n=3821 were subjected to microscopic examination and semi quantitative estimation of yeast culture obtained by inoculated of calibrated volume of urine onto blood, Mac-conkey and HiCrome UTI agar. Clinical parameters of the cases were obtained for analysis. Speciation of Candida was performed using germ tube test, observation of morphology in corn-meal agar and pigment production in HiChrome Candida differential agar. Confirmation of the species identification and anti-fungal susceptibility profile were obtained using VITEK-2 compact system. Results: Total 101 patients were identified with significant candiduria. Community-Acquired Candiduria (CAC was seen in 11 (10.8% of the cases. 23 (22.7% cases of candiduria were associated with pyuria. Concomitant candidemia was observed in 4 (3.9% cases of candiduria The most common species identified was Candida albicans (n=53, 52.4%. The commonest non-albicans Candida species causing significant candiduria cases were C. glabrata and C. tropicalis (n=18, 17.8% each. The antifungal susceptibility testing revealed an overall 94% susceptibility to amphotericin B, 89% susceptibility to flucytosine, 84% & 88% susceptibility to azoles, fluconazole and voriconazole respectively with 90% susceptibility to caspofungin. Significant high linear correlation existed between fluconazole and voriconazole resistance for C. glabrata, C. albicans and C.tropicalis. [Pearson’s correlation coefficient, C. glabrata [r =1.00 (p<0.001], C. albicans [r=0.91 (p<0.001] and C.tropicalis [r=0.79 (p<0.001]. Conclusion: C. albicans was found to the commonest species in our Tertiary Care Center in contrast to the reporting of non-albicans Candida species as the commonest species in most other recent studies. Determination of the antifungal susceptibility profile showed increasing trend of resistance to most antifungal agents, particularly azoles.

  4. A clinico-radiologic study of the various lesions in the oral and maxillofacial region of children

    International Nuclear Information System (INIS)

    Choi, Soon Chul; Lee, Young Ho; Park, Tae Won; You, Dong Soo

    1995-01-01

    Two thousand-two hundred-forty-three cases of various lesions of the oral and maxillofacial region in children under 16 years of age were reviewed. The lesions were classified by 10 groups, osteomyelitis, cysts, benign tumors, malignant tumors, fibro-osseous lesions, developmental disturbances, antral lesions, TMJ lesions, salivary gland lesions, and other lesions. The obtained results were as follows; 1. Developmental disturbances, especially cleft alveolus and palate, was the most common lesions (25.7%), followed by cysts (22.5%), antral lesions (12.7%), benign tumors (11.9%) and osteomyelitis (9.3%). 2. With the time, the incidence of osteomyelitis and malignant tumors has been decreased, but that of developmental disturbances, cysts and antral lesions has been increased. 3. The sex distribution was relatively equal for the entire series, with male predominence in cysts, malignant tumors, developmental disturbances and salivary gland lesions and with female predominance in TMJ lesions. 4. Children with malignant tumors and osteomyelitis were somewhat younger and those with TMJ lesions were somewhat older. 5. Heading the list of each group except osteomyelitis was dentigerous cyst, odontoma, malignant lymphoma, fibrous dysplasia, cleft alveolus and palate, inflammatory change, degenerative change of condylar process, sialolithiasis and simple bone cyst respectively.

  5. Clinico-epidemiological study on canine toxicosis in Effurun/Warri Municipality region of Delta State, Nigeria

    Directory of Open Access Journals (Sweden)

    Kundu F. Shima

    2015-09-01

    Full Text Available The purpose of this study was to provide fundamental information on both the common toxicants and poisoning episodes in dogs within Effurun/Warri municipality region of Delta State of Nigeria from 2011 to 2014. The collected data were grouped according to age, sex, breed, year of occurrence, and toxicant type. The study revealed that a total of 76 dogs comprising 12 breeds were poisoned by several toxicants such as pesticides (69%; n=52/76, household products (12%; n=9/76, food and ndash;poisons (9%; n=7/76, and snakebite envenomation (3%; n=2/76. Mixed breeds (29%; n=22/76, Alsatian (25%; n=19/76, Rottweiler (16%; n=12/76 and indigenous breed (7%; n=5/76 ranked the topmost breeds accounted for most poison emergencies with human and ndash;related factors incriminated. This study provides useful information on episodes of poisoning in dogs in the studied region. The knowledge of agents involved can help veterinarians for accurate diagnosis, and pet owners to cautiously protect their pets from potentially poisonous substances. [J Adv Vet Anim Res 2015; 2(3.000: 357-361

  6. Clinico-Epidemiological Comparison of Delusion-Prominent and Hallucination-Prominent Clinical Subgroups of Paranoid Schizophrenia.

    Science.gov (United States)

    Kreinin, Anatoly; Krishtul, Vladimir; Kirsh, Zvi; Menuchin, Michael

    2015-01-01

    Though hallucinations and delusions are prominent basic impairments in schizophrenia, reports of the relationship between hallucinatory and delusional symptoms among schizophrenia patients are scant. To examine the epidemiological and clinical differences between mainly hallucinatory and mainly delusional subgroups of paranoid schizophrenia patients. One hundred schizophrenia patients, paranoid type, were recruited. In a cross-sectional study, participants were divided into Mainly Hallucinatory (H) and Mainly Delusional (D) subgroups. Demographic variables were compared and clinical characteristics were evaluated using the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, and the Clinical Global Impression Scale. The Quality-of-Life Enjoyment and Satisfaction Questionnaire-18 was used to assess quality of life. Clinically, the H group was more heterogeneous as expressed by the broader range of scores that described the clinical picture of patients in that subgroup (in 43 of 78 variables, 55.13%) and similar ranges of scores (31 of 78 variables, 39.74%) for patients in the D group. Duration of hospitalization was significantly longer in group H than in group D (p=0.047). There was no statistically significant difference between the H and D subgroups in demographic characteristics. There are distinct epidemiological and clinical differences between the H and D subgroups, with more severe positive and negative symptoms and greater functional impairment in the H group. Paranoid schizophrenia patients with prominent hallucinations have poorer prognosis and need intensive therapeutic rehabilitation beginning with onset-of-illness. Further genetic studies and comparisons of fMRI and/or PET findings are warranted to investigate additional distinctive characteristics of these subgroups.

  7. Inflamação esclerosante idiopática da órbita: estudo clinico-patológico

    Directory of Open Access Journals (Sweden)

    Lívia Maria Nossa Moitinho

    2012-10-01

    Full Text Available OBJETIVO: Descrever oito casos de inflamação esclerosante idiopática da órbita, incluindo a análise clínica e histopatológica. MÉTODOS: Estudo retrospectivo através do livro de registros do Laboratório de Patologia Ocular (LPO do Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, no período de 1974 a 2010. Além de revisão de lâminas de todos os casos e das imagens clínicas e de exames complementares recuperadas dos arquivos pessoais dos autores. RESULTADOS: Dentre o total de espécimes submetidos ao LPO (7546 apenas 8 casos receberam diagnóstico final de inflamação esclerosante idiopática da órbita. Em todos os casos houve piora ou deterioração da acuidade visual à despeito do tratamento, com exceção de um, que permaneceu com a mesma visão (percepção luminosa. Em nosso estudo, observamos envolvimento orbitário predominantemente apical. Todos os nossos pacientes foram submetidos à biópsia incisional com finalidade diagnóstica. Também submeteram-se à corticoterapia e em um caso foi associada à radioterapia anti-inflamatória; em dois destes casos, foi utilizado também ciclofosfamida. Dois pacientes com acuidade final sem percepção luminosa tiveram que ser submetidos à exenteração parcial da órbita para tratamento de dor incontrolável. CONCLUSÃO: A inflamação esclerosante orbitária idiopática permanece como uma doença pouco conhecida, de péssimo prognóstico visual.

  8. Correlación clinico-microbiológica en 9 pacientes con fibrosis quística

    Directory of Open Access Journals (Sweden)

    Eloísa Martí Castelló

    1996-08-01

    Full Text Available En pacientes con fibrosis quística la Pseudomonas aeruginosa es el patógeno más importante como causa de infección pulmonar crónica y se ha demostrado que la respuesta inflamatoria del pulmón puede contribuir a la patogénesis de esta infección, con la participación de los mecanismos de defensa específicos e inespecíficos; por lo que se correlacionan las manifestaciones clínicas y microbiológicas en 9 pacientes con fibrosis quística. Los pacientes se diagnosticaron por la clínica y electrólitos en sudor y se les realizó estudio microbiológico de esputo o hisopado profundo, donde se aisló en todos los casos la Pseudomona aeruginosa. También se determinaron en suero los anticuerpos antiPseudomona aeruginosa y se relacionaron los resultados con la clínica. En todos los pacientes se obtuvieron títulos elevados en distintos serotipos determinados y existió relación entre los títulos de anticuerpos y las manifestaciones clínicas. Igualmente se observó disminución de los títulos en los pacientes tratados con esteroides o con tratamiento antiPseudomona.Among patients suffering from cystic fibrosis the Pseudomonas aeruginosa is the most important pathogen as a cause of chronic pulmonary infection and it has been proved that lung inflammatory response may contribute to the pathogenesis of this infection, with the participation of specific and unspecific defence mechanisms. Therefore, clinical and microbiological manifestations are correlated in 9 patients with cystic fibrosis. Patients were diagnosed by the clinic and electrolites in sweat and it was carried out a microbiological study of sputum or deep swab, where the Pseudomona aeruginosa was isolated in all cases. Antipseudomona aeruginosa antibodies in serum were determined and the results were connected with the clinic. Elevated titres were obtained in all patients in different determined serotypes and there was a relationship between antibody titres and clinical manifestations. A decrease of titres in patients treated with steroids or under antipseudomona treatment was also observed.

  9. Clinical behavior of Streptococcus pneumoniae meningoencephalitis Comportamiento clinico y terapéutico de la meningoencefalitis por Streptococcus pneumoniae

    Directory of Open Access Journals (Sweden)

    Raisa Bu-Coifiu Fanego

    2009-12-01

    Full Text Available OBJECTIVE: There was an increased number of cases of meningoencephalitis caused by Streptococcus pneumoniae, after the successful vaccination campaigns against Neisseria meningitidis and Haemophilus influenzae. This paper aims at describing the clinical characteristics, the laboratory findings, the complications, and the therapeutic management of these patients, who have been suffering from this disease since 1993 to 2006. METHOD: Twelve children with Streptococcus pneumoniae meningoencephalitis admitted to the pediatric hospital of San Miguel del Padron, City of Havana in this period were assessed. RESULTS: Children under one year are the most frequently affected. Septic shock and brain edema were the most severe complications. Three patients died, implying that this disease has a serious course. Early treatment of brain edema is very important to reduce mortality. The elective drugs for treatment of these cases of Streptococcus pneumoniae meningoencephalitis were vancomycin combined with cephalosporin, cefotaxime or ceftriaxone type. CONCLUSION: Patients with Streptococcus pneumoniae meningoencephalitis show clinical characteristics, complications, and sequels that are different to other bacterial meningoencephalitis, meaning that they could be helpful for physicians considering the differential diagnosis of meningoencephalitis.OBJETIVO: Existe un incremento de la meningoencefalitis producida por Streptococcus pneumoniae, después de las campañas exitosas de vacunación contra Neisseria meningitidis y Haemophilus influenzae. El objetivo de este trabajo es describir las caracteristicas clinicas, los hallazgos de laboratorio, las complicaciones y el manejo terapéutico de los pacientes que sufrieron esta enfermedad desde 1993 a 2006. MÉTODO: Se estudiaron doce niños con meningoencefalitis por Streptococcus pneumoniae ingresados en el Hospital Pediátrico de San Miguel del Padrón, Ciudad de La Habana en este periodo. RESULTADOS: Los niños menores de un año son los más frecuentemente afectados. El shock séptico y el edema cerebral las mayores complicaciones. Tres pacientes fallecieron. Esta enfermedad ha tenido un curso serio. El tratamiento temprano del edema cerebral es muy importante para reducir la mortalidad. Los medicamentos de elección para tratar la meningoencefalitis por Strepcococcus pneumoniae en los casos estudiados fueron la vancomicina combinada con cefalosporina del tipo de la cefatoxima o la ceftriaxona. CONCLUSION: Los pacientes con meningoencefalitis por Streptoccocus pneumoniae exhibieron características clínica, complicaciones y secuelas las cuales se diferencian de otras meningoencefalitis bacterianas. Por eso estos elementos pueden ayudar a los médicos en el diagnóstico diferencial

  10. A clinico-epidemiological study of pediatric leprosy in the urban leprosy center of a tertiary care institute

    Directory of Open Access Journals (Sweden)

    Sukumaran Pradeep Nair

    2017-01-01

    Conclusions: This study showed a prevalence of 6.65% of pediatric leprosy cases. BT was the most common type of leprosy, and the prevalence of lepromatous leprosy, lepra reactions, and deformity was low.

  11. Comparison between the diagnostic accuracy of clinico-pathological and molecular tests for feline infectious peritonitis (FIP

    Directory of Open Access Journals (Sweden)

    Angelica Stranieri

    2015-07-01

    Full Text Available The aim of this study was to compare the diagnostic accuracy for feline infectious peritonitis (FIP of conventional clinic-pathological tests with that of molecular tests such as routine PCR and PCR followed by the sequencing of the Spike (S gene. Blood, effusion and tissues specimens were collected from 21 FIP suspected cats. In vivo examination consisted of CBC, serum protein electrophoresis, AGP measurement, cytological and biochemical examination and the evaluation of the ΔTNC on effusions, and of molecular tests such the screening PCR (target: 3’UTR region and the PCR directed towards the S gene followed by the amplification products sequencing in order to detect the aminoacidic substitution recently considered diagnostic for FIP1. These molecular techniques were applied to tissues collected during necropsy, which also allowed forming an FIP group (13 cats and a non-FIP group (5 cats based on histology and immunohistochemistry. The best test on tissues was immunohistochemistry (sens: 92.3%; spec: 100%, while the screening PCR suffered of low specificity (spec: 33.3% and the S gene sequencing showed low sensitivity (sens: 69.2%.On effusions, the best tests resulted screening PCR and cytology (sens and spec: 100% in comparison with the ΔTNC measurement (sens: 85.7 %; spec: 100% and the S gene sequencing (sens: 42.8%; spec: 100%.On blood, the best test resulted AGP measurement (sens: 81.8%; spec: 100%, while serum protein electrophoresis showed a surprisingly low sensitivity (sens: 41.7%. Screening PCR (sens: 55.6%; spec: 100% and S gene sequencing (sens: 33.3%; spec: 100% proved again low accuracy.

  12. Clinico-laboratory spectrum of dengue viral infection and risk factors associated with dengue hemorrhagic fever: a retrospective study

    OpenAIRE

    Mallhi, Tauqeer Hussain; Khan, Amer Hayat; Adnan, Azreen Syazril; Sarriff, Azmi; Khan, Yusra Habib; Jummaat, Fauziah

    2015-01-01

    Background The incidence of dengue is rising steadily in Malaysia since the first major outbreak in 1973. Despite aggressive measures taken by the relevant authorities, Malaysia is still facing worsening dengue crisis over the past few years. There is an urgent need to evaluate dengue cases for better understanding of clinic-laboratory spectrum in order to combat this disease. Methods A retrospective analysis of dengue patients admitted to a tertiary care teaching hospital during the period o...

  13. Eficacia do metodo Meir Schneider de autocuidado em pessoas com distrofias musculares progressivas : ensaio clinico fase II

    OpenAIRE

    Lea Beatriz Teixeira Soares

    1999-01-01

    Resumo: As pessoas com distrofias musculares progressivas vivem o limite do conhecimento médico e aguardam resultados de pesquisa da prevenção, reabilitação e mesmo a cura dos indivíduos portadores. Nesse contexto discute-se a eficácia do método Meir Schneider de autocuidado (self-healing) baseado em ensaio clínico fase II em 12 pessoas com distrofias musculares progressivas, sob tratamento ambulatorial intensivo e não intensivo. Foram atendidos 7 portadores de Distrofia Muscular Duchenne- DM...

  14. Contribution clinico-psychologique à l'étude de la schizophrénie des jeunes

    Directory of Open Access Journals (Sweden)

    M. Schachter

    1955-09-01

    Full Text Available Nous présentons l'observation clinique et psychologique d'un jeune homme atteint d'un syndrome schizophrénique; l'étude montre qu'à la puberté il présentait déjà une série de manifestations rentrant dans la sphère du comportement schizophréniforme. Alors, l'examen clinique laissait la porte ouverte à des interpretations libérales, quant à la validité du diagnostic; on aurait pu considérér alors le jeune pubertaire comme un caractériel ou comme un sujet plus ou moins original. Au test de Rorschach pratiqué à ce moment, l'ensemble des constatations faites démontrait l'existence indiscutable d'un attachement net avec l'ambiance. Par contre, à l'âge de 18 ans 9 mois, le tableau schizophrénique est cliniquement indiscutable. Au Rorschach on note des modifications três nombreuses, três significatives (surtout en ce qui concerne la dissolution et la disparition des facteurs de la syntonie. Cependant, le test ne présente pas les caractères considérés comme "spécifiques" de la schizophrénic C'est, par contre, dans le test projectif de van Lennep que la nature dissociative du tableaux clinique fut démontrée de façon claire et nette.

  15. Pelvic splenosis. Clinical case presentation and literature review; Esplenosis pelvica. Presentacion de caso clinico y revision de la literatura

    Energy Technology Data Exchange (ETDEWEB)

    Schalch Ponce de Leon, J.M.; Rivera B, B; Garcia O, R [Centro Medico ABC, Departamento de Medicina Nuclear, Mexico D.F. (Mexico)

    2005-07-01

    A feminine patient of 31 years primigravidas with pregnancy of 6 weeks of gestation by FUM. Splenoctomy antecedent 20 years ago by splenic traumatic rupture. It enters to the service of Gynecology for sudden and intense pelvic pain in iliac left fossa and scarce trans vaginal bled. Ultrasound reports uterine cavity without gestational sack, mass of 3.5x1.4 cm in right annex. She is carried out to laparoscopy with pre surgical diagnosis of 'right ectopic pregnancy'. During the surgery its are found data that indicate probable splenosis in bottom of right sack. It was carried out at simple and contrasted TAC that show vascularized solid tumoration accustomed in bottom of right sack. The hepatosplenic scintillography with colloidal sulfide labelled with {sup 99m}Tc corroborate the diagnostic of pelvic and abdominal splenosis. (Author)

  16. Videoendoscopic and histological characterization of patients with colorectal cancer in the Teaching Clinico-surgical Hospital Comandante 'Faustino Perez Hernandez'

    International Nuclear Information System (INIS)

    Avalos Garcia, Roxana; Ramos Pachon, Carlos Manuel; Barbon Abreu, Mercedes

    2013-01-01

    In Cuba, colorectal cancer is the third cause of mortality after lung and prostate cancer. We developed our work with the objective of arriving to an endoscopic and histological characterization of the patients with colorectal cancer diagnosed in the mentioned hospital

  17. Clinico-MRI study of hemispheric disorder in long-term follow-up cases of multiple system atrophy

    International Nuclear Information System (INIS)

    Konagaya, Masaaki; Miwa, Shigeru; Matsuoka, Yukihiko; Konagaya, Yoko

    1998-01-01

    Twelve cases of multiple system atrophy (MSA) were studied for clinical and MRI findings of the cerebral hemispheric involvement. The subjects consisted of five olivopontocerebellar atrophy (OPCA) type and seven striatonigral degeneration (SND) type. The age at onset was 56.7±8.0 (M±SD) years, duration of illness at the first MRI study 3.2±1.1 years, duration of illness at the last study 8.1±2.2 years, and the following up duration 4.9±2.0 years. The grasping phenomenon was observed in 70% of the cases examined, snout reflex in 80%, slowness of verbal response in 88%, and decrease of spontaneous speech in 100%. Three cases finally fell into the state of mutism. Three out of ten cases were categorized as dementia by HDS-R (Hasegawa Dementia Scale-Revised) test. Besides the progression of the pontocerebellar atrophy and putaminal changes, MRI study revealed progressive frontal lobe atrophy in most cases. At six years after the onset, SND type showed significantly higher incidence of conspicuous frontal lobe atrophy and dilatation of the Sylvian fissure than OPCA type. Cerebral ventricular dilatation was common feature, and atrophy of the temporal and occipital lobes were observed in several cases. We indicated the possible involvement of the cerebral hemisphere, especially the frontal lobe, and higher nervous function in MSA. (author)

  18. Clinico-MRI study of hemispheric disorder in long-term follow-up cases of multiple system atrophy

    Energy Technology Data Exchange (ETDEWEB)

    Konagaya, Masaaki; Miwa, Shigeru; Matsuoka, Yukihiko [Suzuka National Hospital, Mie (Japan); Konagaya, Yoko

    1998-12-01

    Twelve cases of multiple system atrophy (MSA) were studied for clinical and MRI findings of the cerebral hemispheric involvement. The subjects consisted of five olivopontocerebellar atrophy (OPCA) type and seven striatonigral degeneration (SND) type. The age at onset was 56.7{+-}8.0 (M{+-}SD) years, duration of illness at the first MRI study 3.2{+-}1.1 years, duration of illness at the last study 8.1{+-}2.2 years, and the following up duration 4.9{+-}2.0 years. The grasping phenomenon was observed in 70% of the cases examined, snout reflex in 80%, slowness of verbal response in 88%, and decrease of spontaneous speech in 100%. Three cases finally fell into the state of mutism. Three out of ten cases were categorized as dementia by HDS-R (Hasegawa Dementia Scale-Revised) test. Besides the progression of the pontocerebellar atrophy and putaminal changes, MRI study revealed progressive frontal lobe atrophy in most cases. At six years after the onset, SND type showed significantly higher incidence of conspicuous frontal lobe atrophy and dilatation of the Sylvian fissure than OPCA type. Cerebral ventricular dilatation was common feature, and atrophy of the temporal and occipital lobes were observed in several cases. We indicated the possible involvement of the cerebral hemisphere, especially the frontal lobe, and higher nervous function in MSA. (author)

  19. [Clinico-statistical analysis of arterial hypertension complicated with hypertensive crisis in Moscow in 2005-2009].

    Science.gov (United States)

    Gaponova, N I; Plavunov, N F; Tereshchenko, S N; Baratashvili, V L; Abdurakhmanov, V R; Komissarenko, I A; Filippov, D V; Podkopaev, D V

    2011-01-01

    Clinicostatistical analysis of arterial hypertension complicated with hypertensive crisis using data of Moscow A.S.Puchkov Station of Urgent and Emergent Medical Aid revealed 14% rise in number of hypertensive crises during the period from 2005 to 2009. Number of hypertensive crises increased among persons of young age (18-35 years). Frequency of cerebrovascular complications of hypertensive crises was age dependent with maximal values among men aged 36-74 years and women older than 75 years.

  20. Performance of OSL dosimeters in clinical beams from mammography; Desempenho de dosimetros OSL em feixes clinicos empregados na mamografia

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Caio V.; Cabete, Henrique V.; Alves, Fatima F.R.; Pires, Silvio R.; Medeiros, Regina B.; Freitas, Marcelo B. [Universidade Federal de Sao Paulo (HSP/EPM/UNIFESP), SP (Brazil). Escola Paulista de Medicina; Malthez, Anna Luiza M.C. [Universidade Estadual de Campinas (CPG/FEEC/UNICAMP), Campinas, SP (Brazil). Faculdade de Engenharia Eletrica e de Computacao. Programa de Pos-Graduacao

    2015-08-15

    The search for the relationship between dose and mammography image is critical to the quality of clinical practice. In this sense, dosimetry using optically stimulated luminescent detectors (OSLD) is configured as alternative to traditional methods and allows on-site dose checks received by patients. This study aimed to verify the performance of OSL dosimeters in clinical beams typically used in mammography. For this, aluminum oxide detectors, especially designed to reduce interference on the image quality, were exposed to radiation beam combining targets and filters of a mammography equipment with digital imaging system. In addition were also employed lithium fluoride detectors irradiated under the same conditions, together with a ionization chamber for determination of dose values. A homogeneous acrylic phantom was designed and used for simulating different breast and also determine internal dose values under the irradiation conditions. The results allowed the determination of calibration factors (OSL signal x dose) of the exposed detectors to the radiation beams typically used in clinical practice. The phantom images and the comparison between TL and OSL responses suggest the possibility of routine use of the OSL dosimetry system in mammography. (author)

  1. [Clinico-biochemical aspects of human adaptation in central Antarctica as applied to the problems of space biology and medicine].

    Science.gov (United States)

    Kurbanov, V V; Khmel'kov, V P; Krupina, T N; Kuznetscv, A G; Kuz'min, M P

    1977-01-01

    The paper presents the results of clinical, physiological and biochemical examination of 27 polar explorer--members of the 17th Soviet Antartic Expedition at the Vostok station. It gives data on the morbidity rate and describes the development of the asthenic-neurotic syndrome. On the basis of studies of catecholamines and serotonin, the role of the sympatho-adrenal system in the human adaptation to the harsh environments of the Central Antarctica has been shown.

  2. Pelvic splenosis. Clinical case presentation and literature review; Esplenosis pelvica. Presentacion de caso clinico y revision de la literatura

    Energy Technology Data Exchange (ETDEWEB)

    Schalch Ponce de Leon, J.M.; Rivera B, B.; Garcia O, R. [Centro Medico ABC, Departamento de Medicina Nuclear, Mexico D.F. (Mexico)

    2005-07-01

    A feminine patient of 31 years primigravidas with pregnancy of 6 weeks of gestation by FUM. Splenoctomy antecedent 20 years ago by splenic traumatic rupture. It enters to the service of Gynecology for sudden and intense pelvic pain in iliac left fossa and scarce trans vaginal bled. Ultrasound reports uterine cavity without gestational sack, mass of 3.5x1.4 cm in right annex. She is carried out to laparoscopy with pre surgical diagnosis of 'right ectopic pregnancy'. During the surgery its are found data that indicate probable splenosis in bottom of right sack. It was carried out at simple and contrasted TAC that show vascularized solid tumoration accustomed in bottom of right sack. The hepatosplenic scintillography with colloidal sulfide labelled with {sup 99m}Tc corroborate the diagnostic of pelvic and abdominal splenosis. (Author)

  3. Avaliação sistematica dos aspectos clinicos e geneticos de pacientes com epilepsias mioclonicas progressivas

    OpenAIRE

    Maria Isabel Caldeira Rodrigues Morais

    2003-01-01

    Resumo: As Epilepsias Mioclônicas Progressivas (EMPs), formam um grupo raro de desordens geneticamente determinadas e freqüentemente familiais. Caracterizam-se por apresentarem a tríade clínica: epilepsia, mioclonias e declínio neurológico progressivo, como demência e ataxia. As cinco principais causas desta síndrome são: doença de Unverricht-Lundborg (DUL), doença de Lafora (DL), as lipofuscinoses ceroides neuronais (LCN), as encefalomiopatias mitocondriais com fibras vermelhas rajadas (MERR...

  4. Radiological features of Lemierre's syndrome: A case report; Manifestaciones radiologicas del sindrome de Lemierre: a proposito de un caso

    Energy Technology Data Exchange (ETDEWEB)

    Tapia-Vine, M. M.; Gonzalez-Garcia, B.; Bustos, A.; Cabello, J. [Hospital Clinico San Carlos. Madrid (Spain)

    2001-07-01

    Lemierre's syndrome is a type of sepsis caused by anaerobes that is secondary to a pharyngotonsillar infection complicated by suppurative thrombophlebitis of ipsilateral jugular vein and septic emboli. Imaging studies are valuable tools for confirming the diagnosis. Chest x-ray reveals poorly defined cavitated, peripheral, nodular lesions. computed tomography (CT) is useful in confirming the pulmonary lesions, which are suggestive of septic emboli. Doppler ultrasound of the neck plays and indispensable role in demonstrating the internal jugular vein thrombosis. We report the case of patient who presented the characteristic clinical and radiological features of Lemierre's syndrome. (Author) 17 refs.

  5. Aspects of radiological protection on industrial irradiators, design and main uses; Aspectos de seguridad radiologica en irradiadores industriales disenos y principales usos

    Energy Technology Data Exchange (ETDEWEB)

    Peregrina M, A; Martinez A, C [Comision Nacional de Seguridad Nuclear y Salvaguardias, Col. Florida, Mexico, D.F. (Mexico)

    1991-07-01

    The governments of different countries among them Mexico are regulating the use of the gamma irradiation like alternative method for the food conservation, that which implies the use of a radioactive facility with specifications of radiological and physical safety that allow the secure use of the used radioactive material, of there the inquietude of the presentation of this topic.

  6. Radiation protection in radiology services in the municipality of Sao Paulo, SP, Brazil; Protecao radiologica nos servicos de radiologia do Municipio de Sao Paulo

    Energy Technology Data Exchange (ETDEWEB)

    Senise, Paulo H.; Silva, Ezequiel; Ruzene, Anderson A.; Braga, Adriano C.; Spirgatis, Armim, E-mail: paulo.senise@fidi.org.br, E-mail: ezequieI.siIva@fidi.org.br, E-mail: anderson.ruzene@fidi.org.br, E-mail: adriano.braga@fidi.org.br, E-mail: armim.spirgatis@fidi.org.br [Fundacao lnstituto de Pesquisa e Estudo de Diagnostico por Imagem (FIDI), Sao Paulo, SP (Brazil); Medeiros, Regina B., E-mail: regina.bitelli@fidi.org.br [Instituto de Pesquisa e Ensino em Medicina Diagnostica e Terapeutica (IPmed), Sao Paulo, SP (Brazil)

    2013-10-01

    The FIDI company providing service to local health care system is responsible for managing part of the services diagnostic imaging of Sao Paulo in the South and Southeast ( 60 % ), Eastern ( 20 % ) and Midwest (20 %), Brazil. The generation of images in the municipal net is performed in conventional manner. Since 2009 works a maintenance associated with the verification of the performance of radiological equipment (annual) and processing (monthly) one. In 2008, on the occasion of the agreement between the city hall and FIDI, conditions were evaluated for radiological protection in 52 care units of the municipality. Were carried out verification tests of performance in conventional equipment, mammographic and tomographic equipment, in 138 and 71 analog processors, according to current legislation. In 2008 , 33 % of the devices had technical problems that prevented its operation. Currently only 3.4 % of the 91 are in radiological equipment maintenance. In 2008 the majority of radiological equipment had more than 10 years of manufacturing, while today fixed equipment have been replaced by new ones and therefore the use of mammography and generally have 2 to 3 years of manufacture . Currently the 31 processors are operative in 2008, 28 % were out of order. The replacement of most of the equipment associated with program quality and preventive/corrective maintenance has kept the service in accordance with the law. (author)

  7. Experience of the Argentine Radioprotection Society in training in radiological protection; Experiencia de la Sociedad Argentina de radioproteccion en capacitacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Bomben, A M [Sociedad Argentina de Radioproteccion (SAR), Av. del Libertador 8250 of. 122, (1429), Buenos Aires (Argentina)

    2006-07-01

    From its creation in 1967, the Argentine Radioprotection Society (SAR) has as basic purpose promoting all the aspects related with the radiological protection and the nuclear safety. Due to the great increment in the use of radioactive sources in diverse areas, soon it was evident for the SAR the importance and necessity to promote the knowledge of the radioprotection approaches between the users of radioactive sources and ionizing radiations in all its application fields, be these industrial, academic or doctors. From the year 2000, the SAR comes organizing in regular and periodical form basic and specialized courses about radiological safety of radioactive sources for industrial use and profile of oil wells, among others. In this work, the characteristics of the different dictated courses are described whose programs have been developed keeping in mind the requirements of the competent authorities of Argentina. Also, statistical information on the dictated courses and its participants is presented. The number of dictated courses was incremented from 6 (year 2000) up to 16 (year 2005), being also increased significantly the number of participants for course. The dictated courses are theoretical-practical, with a duration average of 20 hs. The educational body is constituted by specialists in the different topics with recognized experience. Its given to the participants notes and support material, as well as copies of the material presented to develop the course. When concluding the courses, its deliver to the participants certifies of attendance and/or approval, as it corresponds. In their headquarters the SAR has didactic facilities and specific equipment for the dictation of the courses. Also accounts with the easiness of dictating those courses outside of their headquarters. This is particularly advantageous for companies or organizations that are seated in points far from the main cities and they should qualify in radiological safety to the personnel but, by operative reasons, this cannot leave its work place during several days. Based on its ining experience the SAR proposes that to be considered a priority the inclusion of a module on radiological protection in the programs of grade of the scientific careers of university level with the purpose of generating conscience about the importance of the radiological protection. (Author)

  8. Parameter calculation tool for the application of radiological dose projection codes; Herramienta de calculo de parametros para la aplicacion de codigos de proyeccion de dosis radiologicas

    Energy Technology Data Exchange (ETDEWEB)

    Galindo G, I. F.; Vergara del C, J. A.; Galvan A, S. J. [Instituto Nacional de Electricidad y Energias Limpias, Reforma 113, Col. Palmira, 62490 Cuernavaca, Morelos (Mexico); Tijerina S, F., E-mail: francisco.tijerina@cfe.gob.mx [CFE, Central Nucleoelectrica Laguna Verde, Carretera Federal Cardel-Nautla Km 42.5, 91476 Municipio Alto Lucero, Veracruz (Mexico)

    2016-09-15

    The use of specialized codes to estimate the radiation dose projection to an emergency postulated event at a nuclear power plant requires that certain plant data be available according to the event being simulated. The calculation of the possible radiological release is the critical activity to carry out the emergency actions. However, not all of the plant data required are obtained directly from the plant but need to be calculated. In this paper we present a computational tool that calculates the plant data required to use the radiological dose estimation codes. The tool provides the required information when there is a gas emergency venting event in the primary containment atmosphere, whether well or dry well and also calculates the time in which the spent fuel pool would be discovered in the event of a leak of water on some of the walls or floor of the pool. The tool developed has mathematical models for the processes involved such as: compressible flow in pipes considering area change and for constant area, taking into account the effects of friction and for the case of the spent fuel pool hydraulic models to calculate the time in which a container is emptied. The models implemented in the tool are validated with data from the literature for simulated cases. The results with the tool are very similar to those of reference. This tool will also be very supportive so that in postulated emergency cases can use the radiological dose estimation codes to adequately and efficiently determine the actions to be taken in a way that affects as little as possible. (Author)

  9. Development of a management system of radiological safety with application to hospitals; Desarrollo de un sistema de gestion de seguridad radiologica con aplicacion a hospitales

    Energy Technology Data Exchange (ETDEWEB)

    Velazquez M, J.D.; Rivera M, T. [CICATA, IPN, Av. Legaria 694, 11500 Mexico D.F. (Mexico); Santos R, J.R. [SEPI, ESIME, IPN, 07738 Mexico D.F. (Mexico)

    2008-07-01

    The medicine is the area that more it has benefited with the implementation of the radiation. However, a great number of incidents/accidents they have happened in hospitals in recent years. The above-mentioned stands out the necessity to improve the acting of the radiological safety management systems in Hospitals. This work presents a Management System of Radiological Safety (SGSR). The SGSR has as fundamental objective the one of maintaining the radiological risks inside acceptable levels. The SGSR is generic and it can be applied in the nuclear medicine, radiodiagnostic, radiotherapy, and in other areas of the health sector where it is required to prevent accidents or incidents that affect the health or the well-being of the worker or user. Also it was diagnosed a Specialties Hospital of the Mexico City using some characteristics of the SGSR. The obtained results show that the SGSR can contribute significantly in the improvement of the quality of the service in the attention to the patients and in the radiological safety. (Author)

  10. Monitors display of radiological images: quality control and response of the observer; Monitores de visualizacion de imagenes radiologicas: control de calidad y respuesta del observador

    Energy Technology Data Exchange (ETDEWEB)

    Cesares Magaz, O.; Catalan Acosta, A.; Hernandez Armas, O. C.; Gonzalez Martin, A. E.; Hernandez Armas, J.

    2011-07-01

    This thesis is aimed to determine the possible change experienced by a human reader response to the qualification of a test image on a monitor diagnostic radiographic image when observed before and after calibration of the monitor following the provisions of the AAPM TG18 protocol. It also quantified the change experienced by the monitor as a result of the calibration, by measuring the luminance response as set out in the protocol.

  11. The radiological safety in the petroleum industry. The behavior toward the prevention; La seguridad radiologica en la industria del petroleo. La conducta hacia la prevencion

    Energy Technology Data Exchange (ETDEWEB)

    Adrian T, W. [Autoridad Regulatoria Nuclear, Subgerencia Control de Instalaciones Radiactivas Clase II y III, Av. del Libertador 8250, Ciudad de Buenos Aires (C1429BNP) (Argentina)]. e-mail: wtruppa@sede.arn.gov.ar

    2006-07-01

    Inside the mark of the regulatory control it takes a preponderant place the control of sealed and open radioactive sources, in oil applications. In this task, the handling of the radioactive sources, the demand of the use of written procedures and the training, they are only some examples, of all those that conform the regulatory control. Among these topics they stand out a series of aspects divided in three big groups: operative radiological safety in the base, in the transport and in the task properly said. Given the great quantity of aspects that should be kept in mind, as well as the integration of all the control processes should be included strongly, aspects of safety and quality culture, and to introduce improvements as for the prevention refers, to correct deviations and remoteness that can be produced, avoiding like this, situations of radiological risk, emphasizing aspects of perception of the risk, training in attitudes, the implementation of audits and verifications of the safety level of the installation and the pursuit and control of the tasks that involve the manipulation of radioactive material, which are described in this work. (Author)

  12. New technologies, virtual reality and multimedia, in Radiation Protection training; Nuevas tecnologias, realidad virtual y multimedia, aplicadaas a la formacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Felipe, A.; Sanchez-Mayoral, M. L.; Lamela, B.; Merino, A.; Sarti, F.

    2003-07-01

    Iberdrola Ingenieria y Consultoria (Iberinco) has developed some computer applications based in New Technologies, Virtual Reality and Multimedia, with the aim to optimise the formation and training of professionally exposed workers as well as to inform the public. The use of the new technologies could be an important help for the workers training. Virtual Reality Projects developed by Iberinco are: a) CIPRES: Interactive Calculations of Radiological Protection in a Simulation Environmental and, b) ACEWO: Workers Control Access to Nuclear Power Plants, virtual Reality could be directly applicable to several aspects related with Radiological Protection Training, for example. An application that workers could used to learn the main aspects of Radiological Protection related with: a) Physical concepts, b) Regulations, c) Use of protective clothing, d) Access into and exit out controlled areas, e) ALARA criterion. An examples is the project ACEWO. A training program based on Virtual Reality systems with simulations of procedures in which the operators could receive high doses. In this way, the operation time and dose could be minimised according to the ALARA criterion owing to the ability of repeating the exercise, or the work, as many times as be necessary, like project CIPRES. Iberinco has been developed an educational CD multimedia on nuclear energy and the protection measures foreseen in the emergency plans for the Spanish Civil Protection Agency, with the aim of being distributed to all the schools placed near a nuclear power plant. (Author) 4 refs.

  13. Development of an informative system on aspects of radiological protection in the medical practices; Desarrollo de un sistema informativo sobre aspectos de proteccion radiologica en las practicas medicas

    Energy Technology Data Exchange (ETDEWEB)

    Lopez B, G.M.; Martinez G, A.; Gonzalez R, N.; Hernandez A, R.; Valdes R, M.; Cardenas H, J.; Zaldivar H, W. [CPHR, Calle 20 No. 4113 e/41 y 47, Playa C.P. 11300 La Habana (Cuba); Diaz B, M.; Machado T, A. [Centro Nacional de Seguridad Nuclear, Ciudad de la Habana (Cuba)]. e-mail: gladys@cphr.edu.cu

    2006-07-01

    Today in day is difficult to imagine the development of the medical practices in the diagnosis and treatment of diverse illnesses without the use of the ionizing radiations. In spite of the diffusion and application of these practices, the patients and the public in general don't have full conscience of like the procedures are carried out and the risks that these involve. For it diverse international and national organizations in the last years recommend to include in the programs of radiological protection, all the information that should be given to the patients and the one public that attend as users to the medical institutions to undergo to procedures that imply the use of the ionizing radiations. In Cuba a growing and quick tendency exists to the introduction of nuclear techniques for medical ends, however paradoxically the relative aspects to the communication to the patients and the public in general about the risks of the procedures to that they will be subjected and in consequence on the measures to minimize them is not adequate. Keeping in mind the above-mentioned, specialists of national centers linked to the control and consultant ship in the topics of radiological protection in the medical practices that use ionizing radiations, they worked in the country in the design of an information system that should contribute to elevate the population's culture before the mentioned aspects. The present work describes the structure of this system in function of the different medical attention levels of our national health system. Additionally it exposes the development of a package of varied informative and training tools among those that are folding, posters, guides, instructions, CD Show that its approach general and specific aspects of the uses and risks of medical practices in nuclear medicine, radiodiagnostic and radiotherapy directed so much to health professionals, patients as public in general. (Author)

  14. The industrial radiography service in Brazil concerning to the radiation protection aspect; O servico de radiografia industrial no Brasil sob o aspecto da protecao radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Martins, M M

    1994-12-31

    A study about the industrial radiography situation in Brazil, concerning to the radiation protection aspects is shown. With this purpose it was made an inventory, with utilization of the file of facilities officially registered in industrial application from Brazilian Nuclear Energy Commission (CNEN). It was evaluated the quantity of accelerators, radiation monitors and radiation workers (health physics, operator). As quality and performance indicators of radiation protection the mean doses and the collective doses were used, and their variation from 1987 to 1990. As deficiency signals of radiological protection programs and procedures were utilized the 175 abnormal event occurred (radiological accident and emergency situation) from 1976 to 1992, after an analysis of their causes. The results showed that, for around 2000 monitored workers, the mean dose equivalent was between 0.83 to 2.70 mSv, and the collective dose, between 1.54 and 6.18 Sv.man, from 1987 to 1990. In this period, it was verified a tendency for reduction of means dose and collective dose values. It indicates a possible improvement of radiation protection services or an influence of economical situation of the country. From 175 abnormal events analysed, 456 persons were exposed, with 7.2% of them receiving doses above 50 mSv. These results were compared with those from others countries, such as United Kingdom and united States. (author). 76 refs, 16 figs, 24 tabs.

  15. Radiation protection in hemodynamics work process: the look of the multidisciplinary team; Protecao radiologica no processo de trabalho em hemodinamica: o olhar da equipe multidisciplinar

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Laurete Medeiros; Klauberg, Daniela; Huhn, Andrea; Melo, Juliana Almeida Coelho de, E-mail: laurete@ifsc.edu.br, E-mail: danielaklauberg@hotmail.com, E-mail: andrea.huhn@ifsc.edu.br, E-mail: julianac@ifsc.edu.br [Instituto Federal de Santa Catarina (IFSC), Florianopolis, SC (Brazil)

    2014-07-01

    The study was conducted in a hemodynamics service of a public hospital in Florianopolis, SC, Brazil. Qualitative research with the participation of 13 professionals from a multidisciplinary team: doctors, technicians, technologists in radiology and nurses. The research material was extracted from the observations, semi-structured interviews and documentary analysis. The responses were grouped into three categories relating to: training of hemodynamic professionals and the perception of radiological protection in the work process; occupational exposure and safety of the professionals of Hemodynamics; and continuing education in hemodynamic service. Professionals are daily exposed to ionizing radiation, and for being long procedures, lead to high levels of exposure in workers. In hemodynamic services the risk of biological effects are cumulative, because radiodiagnostic procedures include issuing the higher doses of ionizing radiation in which the personnel exposure is critical. The workforce in the service researched mostly consists of technical professionals who reported little knowledge of radiation protection and ionizing radiation and that this issue was not addressed during their training. However, despite mention little knowledge about radiological protection, participants demonstrated understand the biological effects, especially with regard to pathologies caused by frequent exposure without protection to ionizing radiation. These professionals said they have no knowledge of the proper use of radiological protection equipment and the dosimeter, and that the institution does not provide all individual protective equipment required for the procedures performed in the hemodynamic service. Permanent education in hemodynamic service is very important part in the work process, though, cited by participants as little effectiveness in the institution, even when the professionals show interest in the area. Knowledge of the team providing hemodynamic service calls directly in a safe and conscious practice for the worker himself, as the protection is the best way to ensure the safety of workers.

  16. Application of Moodle Platformer for training of radiation protection in medicine; Aplicacion de la Plataforma Moodle en la docencia de la proteccion radiologica en medicina

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz-Cruces, R.; Perez, M.; Pastor, J. M.; Pena, L. de la; Perez, A.

    2006-07-01

    A virtual campus, which web address is http://campus virtual.cv.uma.es/, has been created at the University of Malaga. This web site is based on the Moodle Platformer. It consists on a software system designed to help the teacher to create online teaching easily. The main aim of this work is to evaluate the acceptance of this tool by the students, and to compare its utilization with the grades obtained in the Final Exam of June by these students. The whole entrances in the site of the 145 participating students registered trough the course are 7671, which supposes an average of nearly 53 entrances per year per student. The 11.04% of the students have never entered in this site. The students who have obtained the best grades are the ones who have used more this teaching tool. These tools based on new technologies will be a very important support for radiological protection training, which is recommended by International Organizations (EC Report R116 and IAEA Action Plan 2002-2006). (Author)

  17. Radiation Protection Training in Spanish schools of medicine; Analisis de la docencia pregrado de la proteccion radiologica en la licenciatura de medicina en Espana

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz-Cruces, R.; Perez Martinez, M.; Vano, E.; Hernandez Armas, J.; Diez de los Rios Delgado, A.

    2003-07-01

    Radiation Protection should be included in the programme of studies necessary to confer a bachelor's degree in Medicine, according to the Directive 97/43 Euratom on medical exposures and the Report RP116 published by the European commission on Education and Training in radiation protection for medical exposures. To analyse the present training programmes in radiation protection at the Medical School in different Spanish Universities. The syllabus and the contents of the subjects including radiation protection issues in 27 Spanish Schools of Medicine have been revised. Radiation protection subjects are obligatory at present, only at the Schools of Medicine from Cantabria and Malaga. There is a group of Schools of Medicine where radiation protection is an optional matter with an extension of 4,5 credits (45 hours). It also exists some topics in radiation protection in subjects dealing with Medical Physics and General Radiology (with a range value from 1 to 10 hours), in 10 Schools of Medicine. A wide dispersion among the contents of different subjects and the hours of training allocated by the different School are found. It should be useful the harmonization of the programmes. (Author)

  18. Training Programs on Radiological Safety for users of Ionizing Radiations in Peru; Programas de formacion en proteccion radiologica para usuarios de radiaciones ionizantes en el Peru

    Energy Technology Data Exchange (ETDEWEB)

    Medina Gironzini, E.

    2003-07-01

    In Peru, people who work with ionizing radiations must have an authorization (Individual License) as established in the Radiological Safety Regulations, which are the mandatory rules. The Technical Office of the National Authority (OTAN), which is the technical organ of the Peruvian Institute of Nuclear Energy (IPEN) in charge of controlling radiations within the country, grants the authorization after the candidate demonstrates that he/she knows the specific use of the technique using radiations, as well as the aspects related to safety and radiological protection. Since it was created in 1972, the Superior Center of Nuclear Studies (VSEN) from IPEN has carried out different training courses so that people can work safety with ionizing radiations in medicine, industry and investigation. The analysis of the radiological safety programs carried out by CSEN during the last 30 years, which allowed the training of more than 2200 people in the country and, at the same time, made possible the securing of the respective Individual License, is presented in this work. The courses, nuclear medicine, radiotherapy, industrial radiography, nuclear gauges gamma irradiator, etc..., are part of the continuous education program of CSEN. (Author)

  19. Questions to the radiological protection in the Universidad Nacional Autonoma de Mexico; Cuestionamientos a la proteccion radiologica en la Universidad Nacional Autonoma de Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Salas M, B., E-mail: salasmarb@yahoo.com.mx [UNAM, Facultad de Ciencias, Departamento de Fisica, Circuito exterior s/n, Ciudad Universitaria, 04510 Mexico D. F. (Mexico)

    2014-08-15

    In the Physics Department of the Sciences Faculty of the Universidad Nacional Autonoma de Mexico (UNAM) exist at least 3 sites where radioactive sources and generating equipment s of ionizing radiation are managed: The Modern Physics Laboratory, the Radiological Analysis of Environmental Samples Workshop and the Collisions Workshop; the first of them has two neutron sources, in addition to other emitted sources of gamma and beta radiation. The neutron sources are of Americium 241-Beryllium and other of Californium-252 which have been operated outside of the control of the Comision Nacional de Seguridad Nuclear y Salvaguardias (CNSNS) that is the regulator organ in Mexico in nuclear matter, because the Operation License No. 183/85, with file number 657 that protected them, lost their validity from August 13, 1987 (25 years behind), what motivated to that the CNSNS assured them. Later to the closing of the Radiological Analysis of Environmental Samples Workshop was believed that a Barium-133 source had been extracted in an illegal way; an investigation realized by the CNSNS determined that the radioactive source was always inside of the detection systems and radiation measurement, for what this source was never lost. In the Collisions Workshop operated an Experimental Accelerator of Particles that the CNSNS prohibited its operation for not having the corresponding license. These examples can be considered as bad practices of radiological protection that should be pointed out to eradicate their promotion and to avoid this way the exposure to the radiation of the occupational exposed personnel and people in general, being also avoided dose of unnecessary radiation. The Instituto Federal de Acceso a la Informacion Publica y Proteccion de Datos (IFAI) in Mexico was a key factor to obtain the information that allowed the realization of this work that was carried out in the Sciences Faculty of the UNAM. (Author)

  20. Evaluation of radiation packages type A from the center of isotopes in Cuba; Evaluacion radiologica de los bultos tipo A del centro de isotopos de Cuba

    Energy Technology Data Exchange (ETDEWEB)

    Balbona, Zayda Amador; Pijuan, Saul Perez, E-mail: zabalbona@centis.edu.cu [Centro de Isotopos (CENTIS), Mayabeque (Cuba); Gual, Maritza Rodriguez, E-mail: mrgual@instec.cu [Instituto Superior de Tecnologias y Ciencias Aplicadas (InSTEC), la Habana (Cuba)

    2013-07-01

    The Isotope Center (CENTIS) of the Republic of Cuba makes the transportation of its products mainly in packaged type A. To undertake the design of packages, packaging components from 6 producing firms (including those found Amersham, CISBIO and IZOTOP) are studied. From the applicable regulations, security features and requirements are established as well as the technical characteristics of the packaging components. This study evaluated according each radioisotope, product and specific activity, high activity that can be included in a Type A package with the limitation that the dose rate on their surfaces is less than or equal to 2 mSv/h. In addition, each package is characterized taking into account the value of the maximum dose rate at maximum contact and the transport index for the day of transport. For this, the Microshield code using version 5.0.3. The dose rate in contact with the package of {sup 90}Y is calculated using the Monte Carlo code MCNPX version 2.6.0. The maximum possible activity values are obtained for each shielding transport radionuclides CENTIS produced, namely {sup 131}I, {sup 125}I, {sup 32}P, {sup 99}Mo/{sup 99m}Tc, {sup 99m}Tc, {sup 188}Re and {sup 90}Y and 69 radioactive packages type A are evaluated.

  1. Preliminary results of system emergency program to radiologic events of Distrito Federal; Resultados preliminares do programa de atendimento a eventos de origem radiologica no Distrito Federal

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Rosangela da Silveira; Dias, Cintia Melazo; Nicoli, Ieda Gomes [CNEN, Brasilia, DF (Brazil)

    1997-12-31

    This paper intends to present the program conducted by Comissao Nacional de Energia Nuclear (CNEN) in Brasilia related to the controlling of unusual situations involving radiation sources in Distrito Federal. The CNEN in Brasilia has been working in this program since 1994. In this way people has used two mechanisms to contacted, telephone and pager. In 1994, there was one denunciation, five in 1995 and twenty in 1996. The device found in Distrito Federal were: radioactive lightning rod, dentistry and medical X-rays equipment, smoke detectors, research and toxic material. In a period of three years, 1994 to 1996, the radioactive lightning rod an dentistry and medical X-rays equipment represented seventy per cent of all material found. Distrito Federal has never had a real radiological emergency situation but radiological events because, up to now, it has not have lost of control of a radioactive source. The problem that emerges is a psychological. The radioactive symbol found in the material frightens the population. The results show that an emergency planning is necessary in Distrito Federal once that the events occurred since 1996 represented thirty per cent of all events occurred in national territory. (author) 6 refs., 3 figs.; e-mail: cnenbsb at rio.nutecnet.com.br

  2. Evaluation of the nuclear and radiological emergency response system in Brazil; Visao critica do sistema de atendimento a emergencia radiologica e nuclear no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Estrada, Julio J.S.; Azevedo, Eduardo M.; Knoefel, Tom M.J. [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil)

    1997-12-31

    Brazilian Nuclear Energy Commission (CNEN) has made outstanding efforts to improve its nuclear and radiological accident response system since the tragic accident in Goiania, Brazil. Most of these efforts are related to nuclear emergency although radiological accidents are also considered. Several topics are discussed involving those related to planning and preparedness. Some deficiencies that need to be corrected or improved are pointed out 8 refs.

  3. Radiologic safety program for ionizing radiation facilities in Parana, Brazil; Programa de seguridad radiologica para las oficinas de salud en Parana, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, M.F.S.; Tilly Junior, J.G. [Secretaria de Saude do Estado do Parana, Curitiba, PR (Brazil)

    1997-12-31

    A radiologic safety program for inspection, licensing and control of the use of ionizing radiation in medical, industrial and research facilities in Parana, Brazil is presented. The program includes stages such as: 1- division into implementation phases considering the activity development for each area; 2-use of the existing structure to implement and to improve services. The development of the program will permit to evaluate the improvement reached and to correct operational strategic. As a result, a quality enhancement at the services performed, a reduction for radiation dose exposure and a faster response for emergency situations will be expected 2 refs., 1 fig., 2 tabs.

  4. Implementation of an action plan in radiological protection of the patient in Argentina; Implementacion de un plan de accion en proteccion radiologica del paciente en la Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Michelin, S; Perez, M R; Dubner, D [Laboratorio de Radiopatologia, Autoridad Regulatoria Nuclear, Av. Del Libertador 8250 CP 1429, Buenos Aires (Argentina)

    2006-07-01

    The medical irradiations constitute the main contribution to the human exposure to ionizing radiations of artificial character. The growing quantity of practices, facilities and human resources dedicated to such ends, it has increased the concern of regulator organisms and scientific societies by the radiological protection of the patient (PRP). Besides completing it regulatory function in the domains of the medical practices that its concern it, the Nuclear Regulatory Authority (ARN) of Argentina, decided to install an active discussion in order to promoting an action plan in PRP in the national environment. To such end, the ARN organized the First National Day on PRP in December, 2004, with the attendance of professionals of the fields of the Radiodiagnostic, the Nuclear Medicine and the Radiotherapy as well as of representatives of professional associations and authorities of health. In this day the conclusions of the International Conference on PRP (Malaga, 2001) and the approaches of the Directive 97/43/EURATOM adopted in European countries were presented. It was discussed about: practices justification, responsibility of the prescriber doctor, quality systems, dose optimization, reference levels, dosimetry, training of human resources, especially for certain practices (pregnant woman, pediatric radiology and interventionist, PR/118 tomography for the correct application of diagnostic practices and an expert presented in teleconference form the experience of France for the adoption of these guides. During the Second National Day on PRP organized by the ARN (June 2005), received opinions were debated in the different environments in relation to the PR/118 guide and it potential adaptation to the national conditions. Also it was presented the state of advance of the activities developed in relation to the proposed tasks. As a result of this meeting, it was conformed a national net of PRP to which intended to incorporate academic institutions, in order to consider the inclusion of topics of PRP in the medical grade formation. Work groups were constituted in Radiodiagnostic, Radiotherapy, Nuclear Medicine and the PRP of the pregnant woman that agreed the contents and chronograph of a work plan to short and medium term that is at the moment in execution. The continuity of this coordinated action facilitated the execution of the proposed objectives. In this communication the results obtained until the present of the action plan for the PRP implemented in the Argentina starting from the year 2004 are presented. (Author)

  5. Medical response guide for the initial phase of a radiological emergency; Guia para la respuesta medica en la fase inicial de una emergencia radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez, Marina A; Perez, Maria del R

    2007-07-01

    In case of a sanitary emergency, the local community and its health care system are the first aid providers. Therefore, preparedness through education and training programs would allow emergency systems to provide an appropriate first medical response. The main objective of this guide is to give basic guidelines for the medical response management after situations involving radioactive materials, in an easy and simple way. The information contained in this guide is addressed to health care personnel of any local assistance center. (author) [Spanish] Las emergencias que afecten a un numero importante de personas y que tengan como protagonistas agentes 'no convencionales' como lo son las radiaciones ionizantes, deben ser abordadas mediante la implementacion de programas sanitarios especiales. En una situacion de emergencia, generalmente los primeros en proporcionar la ayuda, son la comunidad local y su sistema de salud. Por ello la preparacion previa local, a traves de la capacitacion y el entrenamiento permitira brindar una respuesta inicial adecuada que se articule con un sistema de respuesta en emergencias escalonado y de complejidad creciente. Esto requiere la participacion de las autoridades de salud en cada uno de los niveles de atencion, asi como apoyo de otros sectores para desarrollar sus planes de preparacion y respuesta. La presente guia, como instrumento de capacitacion, tiene como objetivo primario brindar las herramientas basicas para el manejo de la respuesta medica en una situacion de emergencia que involucre material radiactivo, en un lenguaje claro y sencillo, dirigida al personal de salud de todos los centros asistenciales locales. (autor)

  6. LOG: Analyzing navigation trough a tutorial of Radiation Protection; Cuaderno de bitacora: analisis de la navegacion a traves de un tutorial de proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Vega, J. M.; Pena, J. J.; Rossell, M. A.; Calvo, J. L.

    2003-07-01

    Every day, the number of didactic materials presented through Internet, is greater. However, we have not effective tools to obtain the potential academic yield of such a media. The complexity of the Internet protocols, in spite of the easy handling, makes it almost impossible. In this work, a didactic tool to analyse graphically the navigation through a tutorial on radiation protection is presented. For its visualisation, some subjects related with the biogical effects of radiation and with radiological quantities and units have been selected. The graphical representation shows the tour travelled by the user, in our case students of Medicine, and the time employed in eyeing each one of the nodes. The answers to problems about the contents of each node and its graphical representation in the navigation map allow us to follow the learning progress of the students as well as their standard of navigation. The graphical representation analysis of multiple users permits to detect some of the mistakes in the design of the tutorial and to suggest to the author a method for amending these mistakes. The system is developed on LINEX, but it is easily adaptable to other operating systems. (Author) 7 refs.

  7. The maintenance and the radiological safety in gamma irradiation facilities; El mantenimiento y la seguridad radiologica en instalaciones de irradiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Torres C, G [Gerencia de Servicios Tecnicos Nucleares ININ (Mexico)

    1991-07-01

    Presently work the outstanding aspects of the operation and maintenance of the Industrial Irradiator JS 6500 are described that the ININ operates, in the Nuclear Center of Salazar, Estado de Mexico and its relationship with the radiological security for the occupationally exposed personnel. The signal devices are described and of control of the associate teams, as the system of cooling of the source; the plant of treatment of water of the pool and the system of extraction of ozone. On the other hand the procedures are mentioned for the sure operation and the application of the annual programs of maintenance, in their aspects of more interest, to reduce to the maximum the correction of faults, during the routine operation.

  8. Proceedings of the 6. Argentine congress on radiation protection and nuclear safety; Actas del 6. congreso argentino de proteccion radiologica y seguridad nuclear

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-31

    The 6th Argentine Congress on Radiation Protection and Nuclear Safety was organized by the Radioprotection Argentine Society, in Buenos Aires, between the 22 and 24 of september of 1998. In this event, were presented almost 66 papers in the following sessions, about these subjects: 1.- Safety in nuclear installations. 2.- Control of nuclear material and physical protection of nuclear installations. 3.- Programs of quality assurance. 4.- Training, technical information and public information. 5.- Physical dosimetry. 6.- Physical dosimetry and occupational radiation protection. 7.- Exposure of the natural radiation. 8.- Environmental radiological safety. 9.- Biological effects of the ionizing radiations and biological dosimetry. 10.- Radiological protection of the medical practice and the radiological emergencies. 11.- Radioactive wastes management. 12.- Transport of radioactive materials

  9. Method for the development of emergency response preparedness for nuclear or radiological accidents; Metodo para el desarrollo de la preparacion de la respuesta a emergencias nucleares o radiologicas

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This report supplements IAEA emergency preparedness guidance published in the 1980s, and is consistent with the new international guidance. It provides practical advice for the development of an emergency response capability based on the potential nature and magnitude of the risk. In order to apply this method, emergency planners should have a good understanding of the basic radiological emergency response principles. Therefore, other applicable international guidance should be reviewed before using this report. This report provides a practical step-by-step method for developing integrated user, local and national emergency response capabilities. It can also be used as the basis for conducting an audit of an existing emergency response capability.

  10. Radiation protection program by the National Directorate of Nuclear Technology of Uruguay; Programa de proteccion radiologica para la Direccion Nacional de Tecnologia Nuclear de Uruguay

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Salaberry, M

    2002-12-01

    The present work offers to the user of ionizing radiation sources in public and private institutions a basic and synthesized guide of radiological protection indicating obligations and rights that the personnel acquires to carry out functions in these facilities.

  11. Application of Spanish legislation on radiation protection in contaminated soils; Aplicacion de la normativa espanola sobre suelos contaminados en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Trueba Alonso, C.; Robles Atienza, B.

    2013-07-01

    As the developments that have led the regulations on contaminated soils conventional pollutants are more advanced than those due to radioactive contaminants, this work is a state of the art of the current situation and is framed within the developments in R and D for radiation protection of the public and the environment. (Author)

  12. Use of bioindicators in the environmental radiological surveillance of Mexican Nuclear Center; Utilizacion de biondicadores en la vigilancia radiologica ambiental del Centro Nuclear de Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Gaso P, M.I.; Segovia, N.; Herrera, T.; Perez S, E.; Cervantes, M.L.; Quintero, E.; Palacios, J.; Acosta, E. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico); Herrera, T. [UNAM Instituto Biologia, 04510 Ciudad Univ., Mexico D.F. (Mexico)

    1998-07-01

    Cs-137 and K-40 concentrations were determined in soil samples and wild eatable mushrooms at the forest ecosystem of Mexican Nuclear Center and its surrounding area. The evaluation was carried out with a low bottom gamma spectroscopy system including a high-purity Ge detector (HPGe). The local species that showed greater soil-mushroom transference factor, for Cs-137, were Clavariadelphus truncatus, Cortinarius caerulescenc, Gomphus floccosus and Lyophyllum decastes. The Cs-137 levels obtained in the mushroom samples of Nuclear Center, were in general slightly lower than those of adjacent places, which indicates that this Center is not polluting the atmosphere with such radionuclide. (Author)

  13. Arrangements for preparedness for a nuclear or radiological emergency. Safety guide (Spanish Edition); Disposiciones de preparacion para emergencias nucleares o radiologicas. Guia de seguridad

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-15

    Under the Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency, one function of the IAEA is to collect and disseminate to States Parties and Member States information concerning methodologies, techniques and available results of research relating to response to such emergencies. The primary objectives of this Safety Guide, co-sponsored by FAO, OCHA, ILO, PAHO and WHO, are to provide guidance on preparedness and response for a nuclear or radiological emergency, to describe appropriate responses to a range of emergencies, and to provide background information on past experience, thus helping the user to better implement arrangements that address the underlying issues.

  14. Specialized consultant in radiological safety to the Ciudad del Carmen general hospital, PEMEX; Asesoria especializada en seguridad radiologica al hospital general Ciudad del Carmen, PEMEX

    Energy Technology Data Exchange (ETDEWEB)

    Angeles C, A.; Hernandez C, J. E.; Rodriguez A, F.; Garcia A, J

    2003-02-15

    The Ciudad del Carmen general hospital, dependent of PEMEX, It request consultant of the ININ to be able to maintain their sanitary license for the use of X-ray equipment for the radiologic diagnostic.The proposal of the ININ was to be a program of technical attendance, schedule monthly to be able to solve the observations that are presented in the use of those equipment, and that the hospital can conserve its respective sanitary license.(Author)

  15. Aspects of radioprotection in whole body irradiation treatments (TBI); Aspectos de proteccion radiologica en tratamientos de irradiacion de cuerpo total (TBI)

    Energy Technology Data Exchange (ETDEWEB)

    Pinella, Yuliana M. Ayala, E-mail: yayala@crlima.com [Centro de Radioterapia de Lima S.A., Lima (Peru); Chavez, Cesar Picon, E-mail: cesarpicon@yahoo.com [Universidad Nacional de Ingenieria (UNI), Lima (Peru)

    2013-11-01

    Radiation protection occupationally exposed personnel and the public is considered in this study. It was done the experimental determination of the exposure rates at critical points in the area of radiotherapy and it was evaluated the staff dosimetry.

  16. Preparation and response to radiation and nuclear emergencies in case of natural disasters; Preparacion y respuesta a emergencias nucleares y radiologicas en caso de desastres naturales

    Energy Technology Data Exchange (ETDEWEB)

    Vegueria, Pablo Jerez, E-mail: pablo@orasen.co.cu [Centro Nacional de Seguridad Nuclear (CNSN), La Habana (Cuba); Lafortune, J.F., E-mail: padijeff@gmail.com [VP International Affairs, International Safety Research (Canada)

    2013-07-01

    The impact of natural disasters in cities and communities has grown by different causes in different parts of the world. There are several examples of the impact that have caused extreme natural events in facilities and activities in which ionizing radiation are used. The recent example of the accident at the nuclear power plant of Fukushima Daichi with release of radioactive substances to the environment caused by an earthquake and a tsunami show the need of the increasing improvement in the safety of facilities and activities that use ionizing radiation and radioactive materials in general. Planning and response to events of this nature is another aspect that is important and needs attention. The IAEA documents offer a comprehensive and effective guide to achieve an appropriate degree of readiness to respond to nuclear and radiological emergencies in any situation. However, there are specific challenges for planning and response posed a radiological emergency caused by an extreme natural event or occurring simultaneously with this. The present work deals with essential aspects to take into account by the authorities who coordinate the planning and response to radiological emergencies to deal with extreme natural events.

  17. 9RU2 Radiological protection, attention to the detail-EPU; 9RU2 Proteccion radiologica, atencion al detalle-EPU

    Energy Technology Data Exchange (ETDEWEB)

    Padilla C, I. [CFE, Central Laguna Verde, Km. 42.5 Carretera Cardel-Nautla, Veracruz (Mexico)]. e-mail: ipadilla@cfe.gob.mx

    2008-07-01

    To optimize times and movements in a reload project of nuclear fuel in a nuclear plant, where they are programmed more three thousand maintenance activities, modifications, monitoring and inspection in a smaller period to 30 days, and additionally to optimize the individual and collective dose in the same one, turn out to be important challenges where the used strategies must be accompanied of a deep knowledge of the installation in the radiological sense and of the spaces conceptualized in the time. The attention to the detail makes possible that the objectives are fulfilled. During the shutdown of reload 9 of Unit 2 (9RU2) of the nuclear power plant of Laguna Verde, the attention in detail applied in the critical points allowed a saving of dose of 0.7 Sv-person and one deviation of the goal of only +0.85% (smaller to 1% of the goal established like 2 challenge of Sv-person). Analysis of times, movements and training to develop skills in inspection activities in service that requires intervention in the external surface of the reactor vessel to examine the condition of welds, allowed reducing times of execution of 12 to 2 hours. Analysis of the environment and attention to the detail are techniques that allowed optimizing dose in 9RU2 and they were used in the project Power Increase. In this work the strategies of the surroundings and attention in detail applied in 9RU2 would appear and detail attention in the increase of power in the reload 13 Unit 1. (Author)

  18. Training system in radiation protection of workers of a radioactive facility; Sistema de capacitacion en seguridad radiologica de los trabajadores en una instalacion radiactiva

    Energy Technology Data Exchange (ETDEWEB)

    Amador Balbona, Zayda; Perez Pijuan, Saul; Ayra Pardo, Fernando E.; Soria Guevara, Miguel A., E-mail: zabalbona@centis.edu.cu [Centro de Isotopos (CENTIS), Mayabeque (Cuba)

    2013-07-01

    The following topics are addressed: the state of the art of the studies on the biological effects of ionizing radiation, the new national regulations, operational experiences and in the transportation of radioactive materials and those obtained from the radiological events, radioactive waste management and the analysis of culture of safety in the installation. It evaluates the effectiveness of the training system through the analysis of the occurrence of radiological incidents and behavior of occupational exposure.

  19. Training for the medical response in radiological emergency experiences and results; Capacitacion para la respuesta medica en emergencias radiologicas experiencias y resultados

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas Herrera, J.; Lopez Forteza, Y.

    2003-07-01

    The use of the nuclear techniques in the social practice confers a special imporatnce to the relative aspects to the safety of the practices and radiationsources, for what the implementation of efficient programs of radiation protection constitutes a priority. However in spite of the will before expressed, regrettably radiological situations happen accidental assocaited to multiple causes taht suggest the creation of response capacities to intervention before these fortuitous facts. The experiences accumulated in the last decades related with accidental exposures have evidenced the convenience of having properly qualified human resources for the Medical Response in Radiological Emergencies. The training in the medical aspects of the radiological emergencies acquires a singular character. In such a sense when valuing the national situation put onof manifest deficiences as for the training in medical aspects of the radiological emergencies that advised the development of training programs in such aspects for the different response groups linked to the topic. After identified the training necessities and the scope of the same ones, the contents of the training program were elaborated. The program has as general purpose the invigoration of the capacity of the medical response in front of accidental radiological situations, by means of actions that they bear to prepare groups of medical response in the handling of people accident victims and to the identification of potentials,accidental scenarios, as well as of the necessary resources to confront them. The program content approaches theoretical and paractical aspects to the medical aspect to radiological emergencies. The program include the different topics about fundamental of physical biological to radiation protection, radiation protection during exposure of radiological accidents, medical care for overexposed or contaminated persons, drill, exercises and concludes with designation of a strategy as preparation and response in emergency radilogical. In the country they have been developed an important number of training activities that allowed to quality hundred of specialists. It should be meant that our country has also contributed to the preparation in topics of medical response to Latin American specialists. (Author)

  20. Education in radiation protection in the National Customs of Paraguay; Educacion en proteccion radiologica en la Direccion Nacional de Aduanas del Paraguay

    Energy Technology Data Exchange (ETDEWEB)

    Bordon, Oscar, E-mail: obordon@aduana.gov.py, E-mail: obordon@yahoo.com [Direccion Nacional de Aduanas, Departamento de Seguridad Radiologica, Administracion de Aduana de Gical, Mariano Roque Alonso (Paraguay)

    2013-07-01

    According to the IAEA-TECDOC-1312, as it is required by international agreements, the displacement of radioactive material within and among States should be subject to strict regulatory, administrative, safety and technical controls to ensure conditions of technological and physical safety. The Customs Office is one of the institutions responsible for monitoring shipments crossing international borders. Increasing illicit trafficking of radioactive materials, the use of ionizing radiation generating equipment for checking loads, and trade in radioactive substances have informed the need for education in radiation protection of customs officials. Thus, based on a course on radiation protection for Customs officials, organized by the International Atomic Energy Agency, in March 2008 was initiated a course of radiation protection, of 30 hours Carrera Tecnica del Centro de Formacion y Capacitacion Aduanera de Paraguay, which highlights the basic chapters and for transporting, nomenclature, new equipment emitting ionizing radiation and smuggling. Since then, to date, at least 10 groups have completed the training. Within the training program for customs officials, was incorporated a course for radiation protection of operators of baggage scanners with a four-hour program. Finally, since from 2011 and periodically, at various country customs, a workshop on Illicit trafficking of radioactive and nuclear materials is performed. The results of these courses have been very positive, as well as know the proper procedures for dealing with ionizing radiation has increased the safety culture within the institution.

  1. Capacity training for the personnel of radiation monitoring in metal recycling; Curso de capacitacion para el personal que realiza la vigilancia radiologica en el reciclaje de metales

    Energy Technology Data Exchange (ETDEWEB)

    Caveda Ramos, C.A.; Dominguez Ley, O., E-mail: caveda@cphr.edu.cu [Centro de Proteccion e Higiene de las Radiaciones, La Habana (Cuba)

    2013-07-01

    In this work it a course for training for the personnel involved in the radiation monitoring of metal recycling is presented. The contents were elaborated taken into account the IAEA recommendations for the development of capacity and training activities in radiological safety and in the Guide for the control of radioactive material in metal recycling. The program is divided in eleven parts and the duration time is two weeks. Among the main covered topics are the requirements for radiation monitoring in metal recycling; response to detection of radioactive material and effects of the ionizing radiation in man and environment.

  2. Argentine Radiation Protection Society Experience in RP education and training; Experiencia de la Sociedad Argentina de Radioproteccion en capacitacion en Proteccion Radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Bomben, A. M.; Ciallella, N. R.; Thomasz, E.; Rudelli, M.; Gisone, P.; Ventura, M.; Gomez Parada, I.; Signoretta, C.

    2003-07-01

    Since its creation in 1967, the Argentine Radiation Protection Society (SAR) promotes all the radiation protection and nuclear safety aspects not only within the scientific, technical and academic areas, but also to general public. To fulfill this objective, SAR organised training and refresher courses, seminars and workshops on RP subjects. During 2002, SAR organised 7 basic and specialized courses regarding the uses of radioactive materials in industrial applications and the course on medical response in radiological accidents, that was attended by Argentine and other Latin American participants. The programmes of the courses are developed in compliance with the legal requirements and also considering specifics needs. In this paper, the characteristics of the courses are enunciated and basic statistics regarding courses and participants are presented. For the 2003 and 2004, SAR foresees the organisation of 18 courses per year and has the capacity to deliver other courses by request. all the courses are delivered in Spanish language. Based on this educational experience SAR consider a priority the inclusion, of a RP module in all the scientific graduate programmes to generate awareness on the importance of RP. Taking into account the migration of professionals to Europe and North America and the Globalization, SAR advocates the harmonization of RP syllabus to attain an international recognition. (Author)

  3. Radiological assessment occupational radionuclides in a phosphoric acid plant; Evaluacion radiologica ocupacional y distribucion de radionucleidos en una planta de acido fosforico

    Energy Technology Data Exchange (ETDEWEB)

    Bolivar, J. P.; Garcia-Tenorio, R.

    2008-07-01

    On the frame of a research project devoted to the control of the exposure due to natural radiation in several NORM industries located at the South of Spain, a detailed to the production of phosphoric acid has been performed. In addition, the behaviour along the mentioned process of the different radionuclides involved has been analysed. It has been concluded that the effective dose which can be received by the workers of the plant is clearly below 1 mSv/year. And it has been demonstrated that the main route of occupational exposure corresponds to the external radiation due mainly to the permanent presence of a radioactive contamination source in different zones of the plant. This contamination source is associated to the presence of scales in the inner surfaces of pipes and equipment as well as to the presence of sludges in the phosphoric acid storage tanks, which in both cases contain elevated concentrations of 226{sup R}a. Moreover, the 222{sup R}n concentrations inside the plant do not overpass 100 Bq/m{sup 3}, which not constitutes a radiological problem. (Author) 9 refs.

  4. New Network of Automatic Stations integrated in the CSNs Environmental Radiological Surveillance Network; Nueva Red de Estaciones Automaticas integrada en la Red de Vigilancia Radiologica Ambiental del CSN

    Energy Technology Data Exchange (ETDEWEB)

    Parages Perez del Yerro, C.; Garcia Cadierno, J. P.; Calvin Cuartero, M.

    2016-05-01

    In 1992, the Council put into operation a network comprising 25 automatic stations for continuous monitoring of the radiological quality of the air and the detection of anomalous situations. It has now decided to undertake the renewal and modernisation of these installations, incorporating sensors and automatic connection and communication systems based on the best technology currently available. (Author)

  5. Medical response in the initial phase of a radiological or nuclear emergency; Respuesta medica en la fase inicial de una emergencia radiologica o nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez, M; Perez, M R; Dubner, D; Michelin, S; Malvicini, M [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250, Gobierno Autonomo de la Ciudad de Buenos Aires (Argentina)

    2006-07-01

    The frequency of radiological and nuclear accidents is low with relationship to another type of have an accident, but the use of radioactive sources has been increased in the finish decades. Additionally, a growing world concern exists by the eventual use of radioactive material with malevolent ends. These facts put in relevance the necessity to have an appropriate preparation for the medical answer in this type of emergencies. The medical answer consists of different phases: Initial: pre-hospital and in local general hospitals; Intermediate: in local general hospitals and central reference hospitals. Late: in central reference hospitals and the pursuit to long term. The presence of conventional injuries (radio combined injuries) modifies in substantial form the assignment in the priority of the attention, the prediction and the evolution. The establishment of an appropriate triage is outstanding in the initial phase. The present communication approaches the early medical answer, sustained in the anamnesis, the chronology and severity of the symptoms and prodromal signs besides the laboratory results and complementary exams arisen during the first ones 24 to 72 hours. (Author)

  6. Presentation of the first career in Mexico of Technical Professional in Radiological Protection; Presentacion de la primera carrera en Mexico de Profesional-Tecnico en Proteccion Radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Vizuet G, J.; Suarez, G.; Corona Montes de Oca, J.; Arias C, M. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2002-07-01

    The present educational project has the purpose to show the realized work for introducing the first career of Radiological Protection technician in Mexico. There for the developed activities concerning to the integration of the syllabus is described as well as those realized concerning to the participant teaching personnel training in summarized form. The syllabus has been developed with the purpose to fulfil with the training programs established by the Comision Nacional de Seguridad Nuclear y Salvaguardias, as well as those required by the Secretaria de Salud with respect to the fulfilment of the Normas Oficiales Mexicanas set, international recommendations and that suggested by the training guides emitted by the Direccion General de Capacitacion y Produccion of the Secretaria de Trabajo y Prevision Social. (Author)

  7. Radiological protection in a patient during a total body irradiation procedure; Proteccion radiologica en un paciente durante un procedimiento de TBI (irradiacion de cuerpo entero)

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez O, J. O.; Hinojosa G, J.; Gomez M, E.; Balam de la Vega, J. A. [The American British Cowdray Medical Center, I. A. P., Sur 128 No. 143, Col. Americas, 01120 Mexico D. F. (Mexico); Deheza V, J. C., E-mail: johernandezo@abchospital.co [IPN, Escuela Superior de Fisica y Matematicas, Av. Luis Enrique Erro s/n, Edificio No. 9, Unidad Profesional Adolfo Lopez Mateos, Col. Lindavista, 07738 Mexico D. F. (Mexico)

    2010-09-15

    A technique used in the Service of Radiotherapy of the Cancer Center of the American British Cowdray Medical Center (ABC) for the bone marrow transplantation, is the total body irradiation. It is known that the dose calculation, for this irradiation type, is old, since the dosimetric calculation is carried out by hand and they exist infinity of techniques for the patients irradiation and different forms of protecting organs of risk, as well as a great uncertainty in the given dose. In the Cancer Center of the ABC Medical Center, was carried out an irradiation procedure to total body with the following methodology: Computerized tomography of the patient total body (two vacuum mattresses in the following positions: dorsal and lateral decubitus), where is combined the two treatment techniques anterior-posterior and bilateral, skin delineate and reference volumes, dose calculation with the planning system Xi O of CMS, dose determination using an ionization chamber and a lung phantom IMRT Thorax Phantom of the mark CIRS and dosimetry in vivo. In this work is presented the used treatment technique, the results, statistics and the actualization of the patient clinical state. (Author)

  8. Characterization of different qualities in X-rays, for instruments calibration in radiological protection; Caracterizacion de diferentes calidades en rayos X, para calibracion de instrumentos en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Cejudo A, J.; Tovar M, V. M.; Vergara M, F., E-mail: jesus.cejudo@inin.gob.m [ININ, Departamento de Metrologia de Radiaciones Ionizantes, Laboratorio Secundario de Calibracion Dosimetrica, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-09-15

    In the Secondary Laboratory of Dosimetric Calibration in Mexico was realized the qualities characterization of the series X-rays RQR reported in the International Code of Practices in Dosimetry and Diagnostic Radiology No. 457, using attenuator filters of high purity aluminum and ionizing radiation equipment of inherent filtration of 4 mm Be with and emergent X-radiation beam of 40 grades. For the attenuation was used a geometric arrangement with three beam limiters and a monitor camera prepared on the established form in the mentioned technical report, and a spherical ionization chamber with collection volume of 3.6 cm{sup 3}, aligning its geometric center with the focus of X-rays tube to get that the incident radiation direction will be perpendicular to the ionization chamber. From the perspective of the radiological protection is important to know the X-radiation quality for the application dedicated to the instruments calibration and can to give to these the traceability to a reference laboratory, this way the quality combination and reference chamber can give as a result a procedure for the evaluation of the entrance in surface dose to estimate the dose orientate levels, specified in the basic standards of safety. (Author)

  9. Radiological protection in the interventional techniques: experience in the Pain Clinic of the CIMEQ; Proteccion radiologica en las tecnicas intervencionistas: experiencia en la Clinica del Dolor del CIMEQ

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, M. C.; Benitez N, P. P.; Gonzalez G, Y. [Centro de Investigaciones Medico Quirurgicas, Av. 216 Esq. 11B, Playa Siboney, 6096 La Habana (Cuba); Martinez G, A.; Gonzalez R, N. [Centro de Proteccion e Higiene de las Radiaciones, Carretera de la Cantera, Victoria II, Km. 21.5 Guanabacoa, La Habana (Cuba); Sanchez Z, L. R., E-mail: mayka@infomed.sld.cu [Hospital C. Q. Hermanos Ameijeiras, San Lazaro 701, Centro Habana, La Habana (Cuba)

    2014-08-15

    The Pain Clinic of the CIMEQ offers treatment to patients with different pathologies, using interventional techniques as the radiology like visual guide to reach the target structure and to apply the election technique. The personnel that carry out these procedures are inserted in the program of radiological surveillance of the institution, reason for which a radiological event could be detected where the main physician responsible of the service was implied. In this work the results of an investigation are presented realized with the objective of to know the causes of the event and to determine the necessary measures to avoid that this repeats again. The investigation was oriented to three fundamental aspects: medical exam of the affected worker; evaluation of the operational procedures from the radiological protection view point; and dosimetric measurements simulating the real conditions of work for which were used ionization chamber, radiometer and PMMA mannequin. As a result of the medical exam was detected that the main physician of the service did not use during the execution of all the procedures the extremities dosimetry and that he presented a radio induced erythema in the right hand, reason for which he was separated of the activity with ionizing radiations, until the conclusion of the investigation. With relationship to the evaluation of the operational procedures from the radiological protection view point, was verified that the medical physician not carried out any collimation of the beam and he was located in the positions where the dose rate reached the maximum values, frequently introducing the hands in the direct beam; that which implied an overexposure of the superior extremities and a not optimized exposure for whole body. This result was proven with the realized experimental measurements, which gave dose estimated values in extremities of the order of the deterministic effects. The investigation facilitated to introduce modifications in the operational procedures from the radiological protection view point that allowed optimizing the occupational exposure and to avoid the appearance of deterministic effects on the workers of this practice. Parallel was carried out the completion of the protection individual media and working media that allowed the proper application of the mentioned procedures were substituted. On the other hand, this investigation pointed to that the personnel training in radiological protection matter and the control of the occupational exposure in the interventional techniques are indispensable for the safe performance of the medical practice. (author)

  10. Consolidation of use of the CSN-CIEMAT radiological protection educational portal; Consolidacion de la utilidad del portal educativo de proteccion radiologica CSN-Ciemat

    Energy Technology Data Exchange (ETDEWEB)

    Llorente Herranz, C.; Marco Arboli, M.; Fernandez Sanchez, J.; Villaroel Gonzalez-Elipe, R.

    2016-05-01

    he workers of nuclear and radioactive facilities are required to undertake training programmes on radiological protection in order to achieve the accreditations and licences granted by the CSN. Since 2003, the Council has been collaborating with CIEMAT in the development, maintenance and updating of the teaching material for these courses. More than a thousand such courses have been delivered to date and their contents are accessible via Internet. (Author)

  11. Phosphogypsum applications in the cerrado agriculture and his radiological implications; Aplicacao do fosfogesso na agricultura do cerrado e suas implicacoes radiologicas

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Kerley Alberto Pereira de

    2008-07-01

    The rate of generation of phosphogypsum is approximately 4.8 tons for each ton of phosphoric acid produced. The annual world production can be estimated at 150 million of tons. It is classified as NORM (Naturally Occurring Radioactive Material), in other words, it is a solid waste that contains radioactive elements of natural occurrence from the source rock. The large amount of phosphogypsum produced has been attracting attention of radiological protection institutions and environmental protection agencies in the world, given its high potential for contamination of the environment. In Brazil, this material has been used for several decades, especially for agricultural purposes. In this case, the phosphogypsum is used as a source of calcium and sulfur, as conditioner, and for correction of subsurface soil saturated with sodium, potassium and aluminum. Due to the presence of radionuclides in phosphogypsum, it is necessary to understand the mechanisms for transferring of natural radionuclides in the system soil/plant and to evaluate if the use of phosphogypsum in soil contributes to increased exposition of humans to the natural radioactivity. Experiments were accomplished in a greenhouse with lettuce cultivation in two types of soil (sandy and loamy) fertilized with four different amounts of of phosphogypsum. Samples of phosphogypsum, soil, lettuce and drainage water were analyzed being determined the radionuclides of interest ({sup 238}U, {sup 232}Th, {sup 226}Ra, {sup 228}Ra, {sup 2}'1'0Pb and {sup 210}Po). {sup 238}U and {sup 232}Th have been carried out by neutron activation analysis, Ra, Ra and Pb by gamma spectrometry and Po by alpha spectrometry techniques. Finally, Transfer Factor of soil-plant was calculated and the annual contribution to the effective dose committed due to the ingestion of lettuces of the experiment. Analyses of chemical, physical and mineralogical characterization of soil and phosphogypsum samples were also accomplished. The phosphogypsum was classified as Class II A - Not Dangerous, Not Inert, Not Corrosive and Not Reactive. The soil samples analyzed as were acids, with low content of organic matter and high potential acidity. The average of specific activity for {sup 226}Ra in phosphogypsum samples (252 Bq.kg{sup -1}) was below of the maximum level recommended by USEPA, which is 370 Bq.kg{sup -1} for agricultural use. Although the most of the results of mean specific activity of radionuclides present in samples of lettuce present values below the Minimum Detectable Activity (MDA), the Transfer Factors were estimated for those conditions in which the mean specific activity proved to be superior to MDA. The values ranges from 1.8 10{sup -3} to 2.3 10{sup -2} for {sup 232}Th; 3.5 10{sup -2} to 4.1 10{sup -2} for {sup 226}Ra, 2.4 10{sup -1} to 3.2 10{sup -1} for {sup 228}Ra and 3.5 10{sup -2} to 8.5 10{sup -2} for {sup 210}Po, depending on the type of soil used in the planting of the vegetables. In general, the results obtained in the present study indicated that the mobility of radionuclides in both studied soils was low. The effective doses committed calculated well below the limit of 1 mSv.year{sup -1} established by ICRP, for the public in general (4,3 10{sup -3} mSv for the experiments in loamy soil and 7,5 10{sup -3} mSv for the experiments in sandy soil). It is possible to conclude that from the point of view of the radiological protection, the data obtained in this work demonstrated the viability of the use of phosphogypsum in agriculture of the Cerrado, Brazil. (author)

  12. Twenty years of Radiology in RP-10 nuclear reactor protection; Veinte anos de proteccion radiologica en el reactor nuclear RP-10

    Energy Technology Data Exchange (ETDEWEB)

    Zapata, Alejandro L.; Ramos, Fernando T.; Arrieta, Rolando W.B.; Vela Mora, Mariano, E-mail: lzapata@ipen.gob.pe, E-mail: framos@ipen.gob.pe, E-mail: rarrieta@ipen.gob.pe, E-mail: mvela@ipen.gob.pe [Instituto Peruano de Energia Nuclear (IPEN), Lima (Peru)

    2013-07-01

    In this report we present the results about radiation controls during 1990 - 2010, carried out in the Nuclear Reactor RP-10 of the Nuclear Center of Huarangal. These controls and radiological evaluation are of much utility for the radio personnel protection of this one and other reactors, since it allows to compares these variables with respect to the time. From the results obtained in monitoring and radiation controls, we conclude that in no case it has been reached the limits allowed by the Peruvian Regulating Authority. (author)

  13. Quality control of the interpretation monitors of digital radiological images; Controle de qualidade dos monitores de interpretacao de imagens radiologicas digitais: uma revisao

    Energy Technology Data Exchange (ETDEWEB)

    Favero, Mariana S.; Goulart, Adriano Oliveira S., E-mail: mariana@phymed.com.br [PhyMED - Consultores em Fisica Medica e Radioprotecao Ltda, Porto Alegre, RS (Brazil)

    2016-07-01

    The performance monitors has great importance in image quality of digital radiographic systems. In environments without films, it became necessary to implement acceptance testing and quality control monitors used for interpretation of medical images. The monitors dedicated to radiodiagnostic should provide information that represent slight differences in x-ray attenuation or minor differences in some anatomical region of interest. This should also result in small differences in luminance of an image represented. Factors affecting the quality of medical imaging are contrast, noise, resolution, artifacts and distortions. Therefore, a monitor must have specific characteristics, making it possible for the observer to carry out an assessment that leads to better diagnosis. Based on the need to evaluate diagnostic monitors in various radiological applications, this paper presents a summary for implementation and standardization of tests that are recommended by the publication AAPM Report 03. (author)

  14. Historical revision of the exposure magnitude and the dosimetric magnitudes used in radiological protection; Revision historica de la magnitud exposicion y las magnitudes dosimetricas empleadas en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez J, F. [UNAM, Facultad de Ciencias, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Alvarez R, J. T., E-mail: trinidad.alvarez@inin.gob.mx [ININ, Departamento de Metrologia de Radiaciones Ionizantes, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-10-15

    In this work a historical revision of the exposure magnitude development and their roentgen unit (1905 - 2011) is made, noting that it had their origin in the electric methods for the detection of the ionizing radiation in the period of 1895 at 1937. However, the ionization is not who better characterizes the physical, chemical and biological effects of the ionizing radiations, but is the energy deposited by this radiation in the interest bodies, which led historically to the development of dosimetric magnitudes in energy terms like they are: the absorbed dose D (1950), the kerma K (1958) and the equivalent dose H (1962). These dosimetric magnitudes culminated with the definition of the effective equivalent dose or effective dose which is not measurable and should be considered with the operative magnitudes ICRU: H environmental equivalent dose and/or H directional equivalent dose, which can be determined by means of a conversion coefficient that is applied to the exposure, kerma in air, fluence, etc. (Author)

  15. Database for the registration of radiological surveillance in radioactive facilities of CIEMAT; Base de datos para el registro de vigilancias radiologicas en las instalaciones radiactivas del CIEMAT

    Energy Technology Data Exchange (ETDEWEB)

    Marquez Fernandez, J. L.; Carroza Garcia, J. A.; Perez-Cejuela, P.; Vico Ocon, A.; Alvarez Garcia, A.

    2013-07-01

    In the CIEMAT There are 21 Radiation Facilities in which according to the Radiation Protection Manual must considered radiation hazards and / or contamination. The Radiological Protection Service according to this risk It establishes the classification and marking of areas and a monitoring plan that includes the type and extent of radiological periodicity. The information derived from this monitoring be registered and properly stored. Therefore, it has been completed the design of an application that allows technical experts record their actions and also consult records radiation monitoring tasks performed. (Author)

  16. Training in nuclear and radiation safety in Latin American and Caribbean; Capacitacion en seguridad nuclear y radiologica en America Latina y el Caribe

    Energy Technology Data Exchange (ETDEWEB)

    Papadopulos, S.; Diaz, O.; Larcher, A.; Echenique, L.; Nicolas, R., E-mail: spapadopulos@arn.gob.ar, E-mail: odiaz@arn.gob.ar, E-mail: alarcher@arn.gob.ar, E-mail: lechenique@arn.gob.ar, E-mail: rnicolas@arn.gob.ar [Autoridad Regulatoria Nuclear (ARN), Buenos Aires (Argentina); Lombardi, R.; Quintana, G., E-mail: alombar@fi.uba, E-mail: quinta@fi.uba.ar [Universidad de Buenos Aires (FI/UBA), (Argentina). Facultad de Ingenieria

    2013-07-01

    From thirty-three years, Argentina has taken the commitment to train professionals in the field of nuclear and radiation safety for the care and protection of workers and public in general. Sponsored by the IAEA and supported by the Faculty of Engineering of the University of Buenos Aires (FIUBA), an undertaking was made to encourage the training of scientists and experts in the countries of the region in order to establish a strong safety culture in radiation in individuals and maintaining high standards of safety practices using ionizing radiation. In 2012, the Graduate Course in Radiation Protection and Safety of Radiation Sources has acquired the status of 'Specialization' of the FIUBA, a category that further hierarchies skills training in the subject. This is a highly anticipated achievement by the implications for academic institutions, national and regional level, contributing to the strengthening of the Regional Training Center for Latin America and the Caribbean, acknowledged in a long-term agreement between the IAEA and Argentina in September 2008. Due to increased demand for nuclear activity, it is important to continue and deepen further training in radiological and nuclear areas. In order to satisfy both national and regional needs a process of increase on training offer training is being carried out, under the jurisdiction frame of the Nuclear Regulatory Authority. This paper presents the achievements of the country so far as regards training of human resource in radiation protection and nuclear safety in the region and highlights the challenges ahead for the extension of the offer in education and training. (author)

  17. Development of a ceramic material to cover walls to be applied in diagnostic radiological protection; Desenvolvimento de um material ceramico para utilizacao em protecao radiologica diagnostica

    Energy Technology Data Exchange (ETDEWEB)

    Frimaio, Audrew

    2006-07-01

    This study aims to formulate a ceramic composition for wall coating seeking to contribute to the optimization of diagnosis rooms' shielding. The work was based on experimental measures of X-radiation attenuation (80 and 100 kV) using ceramic coating materials containing different ceramic bases (red, white, gres, stoneware porcelain tiles, etc). Among the appraised ceramic bases, the white gres presented better attenuation properties and it was considered the most suitable material for the targets of this work. Different formulations of white gres were studied and altered in order to obtain better attenuation properties. Simulations of ceramic compositions using gres coating were made maintaining the percentages of 12-20% clay; 6-18% kaolin; 12-25% phyllite; 8-14% quartz; 1018% feldspar; 32-40% pegmatite and 6-8% talc in the composition of the necessary raw-material. The quantitative and qualitative chemical compositions of these materials were also evaluated and the most common representative elements are SiO{sub 2}, Fe{sub 2}O{sub 3}, Al{sub 2}O{sub 3}, CaO and Ti{sub 2}O{sub 3}. Formulations containing Pb and Ba oxides were studied, considering that CaO can be replaced by PbO or BaO. The attenuation properties for X-radiation were investigated by computer simulations considering the incident and transmitted X-ray spectra for the different studied compositions and they were compared to the properties of the reference materials Pb, Ba and BaSO{sub 4} (barite). The results obtained with the simulations indicated the formulated composition of gres ceramic base that presented better attenuation properties considering the X-ray energies used in diagnosis (80, 100 and 150 kV). Ceramic plates based on the formulated compositions that presented lower percentage differences related to Pb were experimentally produced and physically tested as wall coating and protecting barrier. Properties as flexion resistance module, density, load rupture, water absorption and X radiation attenuation were evaluated for all produced plates. (author)

  18. The Association of the Heads of European Radiological Protection Competent Authorities (HERCA); La Asociacion de Autoridades Competentes en Proteccion Radiologica (HERCA)

    Energy Technology Data Exchange (ETDEWEB)

    Velasco, R.; RodrigueZ, M.; Amor, I.; Villanueva, I.; Martin Calvarro, J. M.; Aguado, M. D.; Sanchez, M.

    2012-07-01

    In 2007 a European association of regulatory authorities working in the field of radiological protection, known as HERCA, was set up with a view to harmonising the regulatory practices of the different countries, identifying new problems and providing agreed-to solutions. (Author)

  19. Chemical and radiological characterization of meals served by the COSEAS (USP-SP); Caracterizacao quimica e radiologica de refeicoes servidas pelo COSEAS/USP-SP

    Energy Technology Data Exchange (ETDEWEB)

    Favaro, Deborah Ines Teixeira [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), SP (Brazil). Centro do Reator de Pesquisas. Lab. de Analise por Ativacao Neutronica], e-mail: defavaro@ipen.br; Chioccola, Gabriella Saitta; Bortoli, Maritsa; Cozzolino, Silvia Maria Franciscato [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Ciencias Farmaceuticas. Lab. de Alimentos e Nutricao Experimental; Taddei, Maria Helena [Comissao Nacional de Energia Nuclear (CNEN), Pocos de Caldas, MG (Brazil). Coordenacao do Laboratrio de Pocos de Caldas (COLAB); Mazzilli, Barbara Paci [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), SP (Brazil). Div. de Radiometria Ambiental

    2009-01-15

    This study presents the results obtained for the chemical and radiological analyses of lunch meals served in the cafeteria at the University of Sao Paulo-USP (COSEAS restaurant) in Brazil, on 5 non-consecutive days. On each of the five days, the meals were collected in triplicate and then freeze-dried for analysis totalizing 15 samples. The determination of the proximate composition complied with the AOAC standardized methodologies. The content of Ca, Fe, K, Na, Se, and Zn was determined by instrumental neutron activation analysis and the method validation was performed by certified reference materials analyses. Based on the concentration data, the daily intake of each mineral was calculated (corresponding to 40% of the total daily intake) and compared to the new recommendations set by the National Research Council (USA) considering the 19-30 year-old women range group. Comparing the average values obtained in this study with the recommended values, it was possible to verify that for macronutrients and the micronutrients Fe, Se, and Zn the recommendations were followed; for Ca and K they were deficient and exceeded the recommendation value for Na. The radionuclides {sup 40}K, {sup 60}Co, {sup 137}Cs, and {sup 131}I were determined by gamma spectrometry; {sup 90}Sr by liquid scintillation and {sup 210}Po, {sup 234}U, {sup 232}Th, {sup 238}U, {sup 235}U, {sup 228}Th, {sup 230}Th, and {sup 232}Th by alpha spectrometry. All radionuclides are present in concentrations below the limits set by the Food and Agriculture Organization (FAO). (author)

  20. Formation in radiological protection of the personnel of sanitary installations in Peru; Formacion en proteccion radiologica del personal de instituciones sanitarias en el Peru

    Energy Technology Data Exchange (ETDEWEB)

    Medina G, E. [Instituto Peruano de Energia Nuclear, Av. Canada 1470, Lima 41 (Peru)]. e-mail: medina@ipen.gob.pe

    2006-07-01

    All the people that work with ionizing radiations should have a singular license according to that settled down in the effective legal standards in force in Peru. This authorization is granted by the Peruvian Institute of Nuclear Energy (IPEN) after the postulant demonstrates that he can work in sure form in the application where it uses ionizing radiations. From 1972 the Superior Center of Nuclear Studies (CSEN) of the IPEN it has carried out diverse training courses on radiological safety and protection in medicine, industry and research, such it is so until the year 2005 it has organized 458 courses where 5872 people have been qualified in the country. 75% of people was qualified in the period 2000 - 2005. The courses are organized according to the specific work with radiations and in the one case of medical radiodiagnostic, dental radiology, nuclear medicine and radiotherapy has been qualified 2337 people (doctors, medical technicians and technicians) by means of 174 courses made among the years 2000 at the 2005, corresponding 69,75% to people qualified in radiological protection in medical radiodiagnostic. (Author)