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Sample records for clinico radiologica patologica

  1. Conferencia clinico patologica (CPC): paciente previamente sana con insuficiencia respiratoria debida a neumonia intersticial

    National Research Council Canada - National Science Library

    Catano Correa, Juan Carlos; Serna Ortiz, Carlos Andres; Arias Restrepo, Luis Fernando; Munoz Ortiz, Edison

    2013-01-01

    .... Se diagnostico sida de novo y neumonia intersticial asociada, todo lo cual progreso hasta la falla ventilatoria, que fue refractaria al tratamiento dirigido hacia los oportunistas identificados...

  2. SKELETAL FLUOROSIS- AN EPIDIMIO-CLINICO-RADIOLOGICA L STUDY

    Directory of Open Access Journals (Sweden)

    Prasanta Kumar

    2013-03-01

    Full Text Available ABSTRACT : Skeletal fluorosis is endemic problem in many part s of world including India as well as West Bengal effecting mainly low socio-econ omic group of populations. This study is to detect the epidemiological and clinical as well as r adiological survey to detect and help to prevent the morbidity and mortality of the people fro m the so called slow environmental poison

  3. Hiperprolactinemia : expressao clinica, hormonal e radiologica em pacientes femininas, antes e durante o tratamento clinico

    OpenAIRE

    Elaine Sangali Mallmann

    1993-01-01

    A hiperprolactinemia constitui-se num achado laboratorial que quando resultante de secreção inapropriada, pode indicar tanto um processo patológico orgânico, como uma desordem funcional reversível. Representa o distúrbio hipofisário mais frequentemente encontrado na prática clinica e constitui um dos aspectos mais importantes no estudo da endocrinologia da reprodução. As hiperprolactinemias de causas não fisiológicas são secundárias mais frequentemente a efeito farmacológico, presença de tumo...

  4. Valoracion digital de indices de atenuacion radiologica de estructuras anatomicas normales y materiales dentales observables en imagenes panoramicas

    National Research Council Canada - National Science Library

    Rojas, Mauricio Rudolph; Lopez-Videla Montano, Gianna; Zuluaga Guzman, Carmen Lucia

    2009-01-01

    Introduccion: el desarrollo tecnologico vertiginoso, aplicado al diagnostico mediante imagenes radiologicas digitales ha abierto una nueva dimension en la valoracion cualitativa y cuantitativa de los componentes...

  5. Lichen Planus-a Clinico-histopathological

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    Garg Vijay

    2000-01-01

    Full Text Available The clinico-histopathological features of 75 patients of lichen planus were studied. The male to female ratio was 1:13. The largest number of patients (30.6% fell into the 31-40 year age group. Two patients had systemic hypertension. There was no history of lichen planus in the family. All patients presented with severe itching within 1-2 months of onset. Papular lesions were seen in 72% and papules with plaques were seen 16%. Lower limbs were involved in 38% of cases. Mucosal involvement was seen in 24% in addition to skin involvement ; nail involvement hypertrophicus (17.3%. Lichen planopilaris and oral lichen planus were uncommon. Clinico-histopathological discrepancies were observed in 7 patients. Civatte bodies were seen in only 37% of cases.

  6. [Clinico-radiological profile of acute disseminated encephalomyelitis in the childhood population. A retrospective analysis of a series of 20 patients in a tertiary hospital].

    Science.gov (United States)

    Tomás-Vila, Miguel; Menor, Francisco; Otero-Reigada, M Carmen; Pérez-Tamarit, Amparo; Téllez de Meneses, Montserrat; Pitarch-Castellanos, Inmaculada

    2014-01-01

    Introduccion. La encefalomielitis aguda diseminada (EAD) es un trastorno inflamatorio del sistema nervioso central mediado inmunologicamente y de patogenia desconocida. Puede presentarse en cualquier edad, pero es mucho mas frecuente en niños. La EAD no tiene marcador biologico especifico y el diagnostico se basa en hallazgos clinicos y neurorradiologicos. Objetivo. Mejorar el conocimiento del perfil clinicorradiologico de esta enfermedad. Pacientes y metodos. Estudio retrospectivo con inclusion de pacientes menores de 14 años ingresados en un hospital terciario en los ultimos 15 años con el diagnostico de EAD. Se revisaron antecedentes, signos clinicos de presentacion, datos analiticos en sangre/liquido cefalorraquideo y la semiologia radiologica. En 16 casos se realizo un seguimiento medio de 25 meses. Resultados. Se revisaron 20 pacientes, un 70% niños, con una edad media de 4,4 años. El 40% tuvo un episodio febril previo. El 85% presento fiebre o vomitos, y el 70%, afectacion del estado de consciencia. Predominaron los deficits motores (45%), las convulsiones (35%) y la afectacion de pares craneales (30%). Tres niños presentaron una evolucion recidivante, y otros tres, secuelas motoras. Los estudios de resonancia magnetica mostraron lesiones hiperintensas en secuencias T2, con patron de realce escaso o nulo, que predominaron en los talamos (70%), la medula (67%) y la sustancia blanca subcortical (50%). En dos pacientes se diagnostico EAD hemorragica. Conclusiones. La EAD representa una entidad con importante afectacion general y repercusion neurologica, que muestra un potencial secuelar considerable. Los datos clinicoanaliticos y la resonancia magnetica cerebral y medular son relevantes para el diagnostico inicial y seguimiento de pacientes con EAD.

  7. Clinico- Pathological Study Of Ichthyosis Vulgaris

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    Nandy Utpal

    1997-01-01

    Full Text Available A clinico- pathological study of 28 cases of ichthyosis vulgaris appeared with in the age of 5 years. The presence of the disease since birth was also found. While most (24 patients showed a diminution of severity in summer with an aggravation during winter, 4 patients followed the opposite seasonal pattern. Only in 4 patients, fine scales in the scalp were detected. One patient showed an affection of flexures. There was also a low occurrence of palmo- planter hyperkeratosis, follicular keratosis, fissuring of hands and feet and atopy.

  8. Implementation of the procedure of high radiation of the forum about radiological protection in the health care environment; Implantacion del procedimiento de alta radiologica del foro sobre proteccion radiologica en el medio sanitario

    Energy Technology Data Exchange (ETDEWEB)

    Castro Novais, J.; Pardo Perez, E.; Molina Lopez, M. Y.; Ruiz Maqueda, S.; Maldonado Suarez, A.

    2013-07-01

    The objective of this work is to present the results of the implementation in our hospital the procedure of high radiological in patients treated with 131 I described in the document presented by the Forum on Radiation Protection in the Health Environment formed by the Consejo de Seguridad Nuclear and the Spanish societies of Fisica Medica and Proteccion Radiologica. (Author)

  9. Dermopathy of Graves′ disease: Clinico-pathological correlation

    Directory of Open Access Journals (Sweden)

    Sagili Vijaya Bhaskar Reddy

    2012-01-01

    Full Text Available Dermopathy of Graves′ disease is a classical, but uncommon extrathyroidal manifestation of Graves′ disease. The images of a typical case of dermopathy of Graves′ disease are presented along with clinico-pathological correlation.

  10. Estudio clinico y molecular del sindrome de Noonan

    National Research Council Canada - National Science Library

    Cammarata-Scalisi, Francisco; Neri, Giovanni; Pomponi, Maria Grazia; Mancano, Giorgia; Da Silva, Gloria; Avendano, Andrea; Lacruz-Rengel, Maria Angelina; Stock, Frances; Sosa, Angel

    2012-01-01

    .... Se reporta el caso de un lactante mayor masculino, de 18 meses de edad, evaluado de forma multidisciplinaria con diagnostico clinico y molecular de sindrome de Noonan, con la mutacion en sentido...

  11. [Clinico-roentgenological semiotics of the chest damage in polytrauma].

    Science.gov (United States)

    Zamiatin, P N; Panchenko, E V; Grigor'ian, G O; Goloshchapova, E V

    2006-10-01

    There are presented the main clinico-roentgenological signs of the chest damage in the injured persons, suffering polytrauma, according to the data from the specialized department of traumatic shock and polytrauma.

  12. Dermopathy of Graves' disease: Clinico-pathological correlation.

    Science.gov (United States)

    Reddy, Sagili Vijaya Bhaskar; Gupta, Sushil Kumar; Jain, Manoj

    2012-05-01

    Dermopathy of Graves' disease is a classical, but uncommon extrathyroidal manifestation of Graves' disease. The images of a typical case of dermopathy of Graves' disease are presented along with clinico-pathological correlation.

  13. Inappropriatezza prescrittiva delle colonscopie: un audit clinico

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    Matteo Marcosignori

    2012-12-01

    Full Text Available Background. La colonscopia è una tecnologia diagnostico-terapeutica ad ampia diffusione, ma ad elevato rischio di inappropriatezza. Infatti, la letteratura ha più volte ribadito la necessità di strategie per verificarne l’appropriatezza prescrittiva, suggerendo gli strumenti necessari per raggiungere questo obiettivo. Nella zona di Ancona si è assistito negli ultimi anni ad un continuo incremento del numero di richieste di colonscopie con conseguente allungamento delle liste di attesa e aumento della spesa. Obiettivi. Pianificare e condurre un audit clinico finalizzato a misurare l’appropriatezza prescrittiva delle colonscopie nella zona di Ancona, identificando le più frequenti indicazioni inappropriate e le principali categorie di prescrittori inappropriati. Metodi. Studio osservazionale prospettico che ha incluso pazienti sottoposti a colonscopia dal 1 novembre 2008 al 28 febbraio 2009, in tre unità operative di endoscopia digestiva nella zona di Ancona. L’appropriatezza delle prestazioni è stata valutata dal confronto con gli standard assistenziali definiti dall’American Society for Gastrointestinal Endoscopy, adattati al contesto locale da un gruppo di lavoro multiprofessionale. Risultati. Su 1.082 colonscopie analizzate, il tasso di appropriatezza è risultato del 58,4%. Le principali indicazioni inappropriate rilevate sono “sorveglianza dopo rimozione di polipi non cancerizzati”, “screening del cancro del colon-retto”, “dolore addominale acuto”, “stipsi cronica”. Tra i principali prescrittori inappropriati i gastroenterologi, i medici di medicina generale (MMG e i chirurghi. Gli esami con indicazioni appropriate hanno dimostrato maggiore probabilità di portare a riscontri endoscopici significativi, in particolare a lesioni cancerose. Un numero limitato di neoplasie maligne è stato individuato anche nel corso di colonscopie inappropriate. Limiti. Le tre UU.OO. coinvolte non hanno contributo all

  14. Clinico-histologic conferences: histology and disease.

    Science.gov (United States)

    Shaw, Phyllis A; Friedman, Erica S

    2012-01-01

    Providing a context for learning information and requiring learners to teach specific content has been demonstrated to enhance knowledge retention. To enhance students' appreciation of the role of science and specifically histology in clinical reasoning, disease diagnosis, and treatment, a new teaching format was created to provide clinical context, promote integration and application of science knowledge, and to foster peer teaching and learning: the Clinico-Histologic Conference (CHC) for the Mount Sinai School of Medicine Histology course. Teams of six students were each assigned specific disease processes and were charged with creating oral presentations and handouts that taught their classmates about the clinical manifestations, etiopathogeneses, diagnoses, and treatments of the assigned processes, along with comparisons of normal histology to the pathology of the disease. Each team also created four questions, some of which were used on Histology written examinations. The physician facilitator evaluated the presentation and handouts. About two-thirds of students agreed the CHC enhanced appreciation of the importance of histology, provided a context for integration and application of basic science to patient care and enhanced their ability to teach their peers. Student feedback demonstrated that the CHCs were successful in promoting teamwork, peer teaching, and the application of histology to diagnose diseases. The authors believe that teaching basic science content in this new format enhanced student learning and application of medical knowledge, and that this new teaching format can be adopted by other medical school courses.

  15. Verrucous hyperplasia: A clinico-pathological study.

    Science.gov (United States)

    Hazarey, Vinay K; Ganvir, Sindhu M; Bodhade, Ashish S

    2011-05-01

    Oral verrucous hyperplasia (OVH) is a premalignant lesion that may transform into an oral cancer. The present retrospective study was carried out to analyze the clinico-pathological features of verrucous hyperplasia (VH). Total 19 diagnosed cases of verrucous hyperplasia were retrospectively analyzed for demographic, clinical and histopathological features including dysplasia. Average age of occurrence of lesion was 4 (th) decade of life, with male predominance (2:1) and common site of occurrence being buccal mucosa. Clinically it present as verrucous exophytic growth with sharp or blunt projections on surface, which corresponds histologically. Tobacco lime quid placement in buccal vestibule was key etiologic factor. Histopathologicaly 68% cases showed dysplasia out of which moderate dysplasia predominates (42%). Moderately dysplastic cases were found to be associated with mixed habit pattern. Maximum cases were treated with excision. Biopsy specimen comprising of adjacent normal epithelium is key in distinguishing verrucous hyperplasia from verrucous carcinoma. Clinical behavior and recurrence potential needs to be assessed with long term follow up studies.

  16. Cutaneous vasculitides: Clinico-pathological correlation

    Directory of Open Access Journals (Sweden)

    Gupta Suruchi

    2009-01-01

    Full Text Available Background: Cutaneous vasculitis presents as a mosaic of clinical and histological findings. Its pathogenic mechanisms and clinical manifestations are varied. Aims: To study the epidemiological spectrum of cutaneous vasculitides as seen in a dermatologic clinic and to determine the clinico-pathological correlation. Methods: A cohort study was conducted on 50 consecutive patients clinically diagnosed as cutaneous vasculitis in the dermatology outdoor; irrespective of age, sex and duration of the disease. Based on the clinical presentation, vasculitis was classified according to modified Gilliam′s classification. All patients were subjected to a baseline workup consisting of complete hemogram, serum-creatinine levels, serum-urea, liver function tests, chest X-ray, urine (routine and microscopic examination besides antistreptolysin O titer, Mantoux test, cryoglobulin levels, antineutrophilic cytoplasmic antibodies and hepatitis B and C. Histopathological examination was done in all patients while immunofluorescence was done in 23 patients. Results: Out of a total of 50 patients diagnosed clinically as cutaneous vasculitis, 41 were classified as leukocytoclastic vasculitis, 2 as Heinoch−Schonlein purpura, 2 as urticarial vasculitis and one each as nodular vasculitis, polyarteritis nodosa and pityriasis lichenoid et varioliforme acuta. Approximately 50% of the patients had a significant drug history, 10% were attributed to infection and 10% had positive collagen workup without any overt manifestations, while 2% each had Wegener granulomatosis and cryoglobulinemia. No cause was found in 26% cases. Histopathology showed features of vasculitis in 42 patients. Only 23 patients could undergo direct immunofluorescence (DIF, out of which 17 (73.9% were positive for vasculitis. Conclusions: Leukocytoclastic vasculitis was the commonest type of vaculitis presenting to the dermatology outpatient department. The workup of patients with cutaneous vasculitis

  17. Clinico-radiological spectrum of reversible splenial lesions in children.

    Science.gov (United States)

    Kashiwagi, Mitsuru; Tanabe, Takuya; Shimakawa, Shuichi; Nakamura, Michiko; Murata, Shinya; Shabana, Kousuke; Shinohara, Jun; Odanaka, Yutaka; Matsumura, Hideki; Maki, Koh; Okumura, Kenichi; Okasora, Keisuke; Tamai, Hiroshi

    2014-04-01

    Recently, many cases of children presenting reversible splenial lesions during febrile illness (RESLEF) have been reported; however, their overall clinico-radiological features are unclear. To describe the clinico-radiological features, we retrospectively reviewed the etiology (pathogen), clinical course, laboratory data, magnetic resonance imaging and electroencephalography (EEG) findings, therapy, and prognosis of 23 episodes in 22 children (1 child recurred) who presented neurological symptoms, with RESLEF. The etiologies (pathogens) varied. Seizure occurred in 7 episodes, disturbance of consciousness (DC) in 13, and delirious behavior in 18. Serum sodium levels cases. Slow waves were observed on EEG in 10 episodes. Methylprednisolone pulse therapy was given in 7 cases. No case resulted in neurological sequelae. Among 23 episodes, clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) was diagnosed in 6 episodes, whereas non-MERS was observed in 17 episodes. No difference was observed in almost all the clinico-radiological features' data between the 2 groups. The largest differences were observed in the rate of purposeless movement, DC, extension of the abnormal lesions outside the splenium, and marked slowing of background activity on EEG. RESLEF exhibit a spectrum of clinico-radiological features. These results suggest that non-MERS and MERS both are a part of a larger pathological condition, which we have termed as RESLEF spectrum syndrome. Given the view that such a syndrome exists, the clinical characteristics and position of non-MERS and MERS become clear.

  18. Project Clinico. Final Evaluation Report, 1992-93. OREA Report.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Research, Evaluation, and Assessment.

    Project Clinico, a federally-funded bilingual education project, served 356 special education students of limited English proficiency in its second year of operation at six elementary schools in New York City (New York). The project provided special and modified instructional services for these students, consultation and training to teachers,…

  19. Calcifying epithelial odontogenic tumor: a clinico-radio-pathological dilemma.

    Science.gov (United States)

    Hada, M S; Sable, M; Kane, S V; Pai, Prathamesh S; Juvekar, S L

    2014-01-01

    The calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasm of mandible in adults. The presentation of this entity is varied and often confused with a variety of mucosal and jaw lesions and clinical, radiological, and pathological feature of CEOT often-mimic malignancy. The objective of this report is to highlight the clinical features and radiological findings which should arouse suspicion of a benign lesion and importance of providing adequate clinical information to the pathologist to attain accurate diagnosis.We discussed two cases with tumors located in the maxilla. Both presented as expansile lesions with one biopsy proven squamous cell carcinoma. Both were pursued with clinico-radiological suspicion of benign lesions and confirmed with pathological correlation of histology and immunohistochemistry as CEOT. Therefore a High index of suspicion and clinico-radiological information are the key feature for diagnosis of this rare tumor.

  20. Carga inmediata sobre implante unico: estudio clinico prospectivo.(ARTICULOS ORIGINALES DERIVADOS DE INVESTIGACION)

    National Research Council Canada - National Science Library

    Arango B., Paola Andrea; Arismendi E., Jorge Alberto; Porras, Andres Felipe

    2009-01-01

    ... y disminucion del tiempo total de tratamiento. Se hizo un estudio prospectivo controlado para la colocacion de implantes en casos clinicos de restauracion de diente unico que recogiese el consenso propuesto en la literatura para evaluar el exito...

  1. Valoracion de parametros clinicos y lesiones en organos de cerdos durante el periodo posdestete

    National Research Council Canada - National Science Library

    Mejia-Medina, Julian; Rincon-Ruiz, Juan; Gutierrez-Vergara, Cristian; Correa-Londono, Guillermo; Lopez-Herrera, Albeiro; Parra-Suescun, Jaime

    2012-01-01

    .... En el Centro de Investigacion San Pablo de la Universidad Nacional de Colombia sede Medellin, se evaluaron los parametros clinicos y las lesiones en organos internos en dieciseis cerdos destetados...

  2. [Clinico-psychopathological characteristics of a group of mental patients identified at the internal medicine clinic].

    Science.gov (United States)

    Ostroglazov, V G; Lisina, M A

    1990-01-01

    The authors provide the clinico-psychopathological characteristics of mental patients revealed for the first time during a clinico-epidemiological study of the district therapeutic population. The predominance among them of the somatic psychopathological syndromes was established. The overwhelming majority of those conditions were found to belong to multifactorial mental diseases in whose etiology and pathogenesis the key role is played by interaction between exogenous (psychogenous) and endogenous (thymopathic) factors.

  3. Clinico-mycological study of tinea capitis in Pondicherry

    Directory of Open Access Journals (Sweden)

    Reddy BSN

    1991-01-01

    Full Text Available A clinico-mycological analysis of 68 consecutive clinically diagnosed tinea capitis patients confirmed that the disease affects more commonly prepubertal children of either sex. Salient clinical features in order of frequency included patchy hair loss, scaly patches, black dots and inflammatory lesions with erythema, vesiculation and boggy swelling. Scaly type (36.9% was the most commonly encountered clinical pattern followed by black dot (33.8% and kerion (29.3%. Direct microscopic examination of the affected hair with 20% KOH revealed evidence of fungus in all patients with endothrix (58.8% being the common pattern noted. The rate of culture positivity of the aetiologic fungus grown on Sabouraud′s dextrose agar medium was 82.3%. T. violaceum (66.2% was the most frequently isolated fungus accounting for both inflammatory as well as non-inflammatory lesions.

  4. Cutaneous syncytial myoepithelioma:: Clinico-pathological features and differential diagnosis.

    Science.gov (United States)

    Pizzi, Marco; Facchin, Federico; Kohlscheen, Eva; Sartore, Leonardo; Salmaso, Roberto; Bassetto, Franco

    2016-10-01

    Cutaneous syncytial myoepithelioma (CSM) is a very rare tumor belonging to the spectrum of skin myoepithelial lesions. CSM usually affects the upper extremities of young to middle aged patients and is characterized by peculiar morphological and immunohistochemical features. Unlike classic myoepithelioma, CSM is composed by a densely packed proliferation of spindled to histiocytoid cells, which are variably positive for EMA, S100, SMA, and frequently negative for cytokeratins and GFAP. The peculiar histopathology and the extreme rarity of such lesion (less than 40 cases reported in the literature) can make the diagnosis of CSM a true challenge. In the present case, we report the clinico-pathological features of a primary CSM occurring in a 38 year-old Caucasian man. The differential diagnoses of such lesion are also briefly discussed.

  5. Clinico-pathological study of 30 unicystic ameloblastomas.

    Science.gov (United States)

    Roos, R E; Raubenheimer, E J; van Heerden, W F

    1994-11-01

    The clinico-pathological records of 30 unicystic ameloblastomas collected over a period of 10 years were studied. The mean age at diagnosis was 18.0 years (SD +/- 8.1), most lesions were located in the mandible and were frequently associated with impacted teeth, root resorption and tooth displacement. The unicystic ameloblastomas in 11 patients (4 females and 7 males) exhibited invasion of the fibrous wall, 4 cases (1 female and 3 males) showed intra-luminal proliferation and the remaining 15 specimens (9 females and 6 males) were lined by non-proliferating ameloblastic epithelium. Two cases recurred 3 and 7 years after initial surgical removal. This study reveals the potential aggressive behaviour of unicystic ameloblastomas and underlines the importance of a thorough microscopic examination for sub-classification.

  6. Evaluation of node involvement in non small cell bronchogenic carcinoma. CT-pathology correlation; Valutazione del fattore <> nel carcinoma polmonare non a piccole cellule. Correlazione tra tomografia computerizzata e anatomia patologica

    Energy Technology Data Exchange (ETDEWEB)

    Pirronti, T.; Macis, G.; Sallustio, G.; Minordi, L.M.; Marano, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Radiologia; Granone, P. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Patologia Chirurgica; Vecchio, F.M. [Rome Univ. Cattolica del Sacro Cuore, Rome (Italy). Ist. di Anatomia Patologica

    2000-05-01

    densita' omogenea e' stato considerato reattivo; infine e' stato considerato metastatico, indipendentemente dalle dimensioni, quando erano presenti i seguenti segni: ipodensita' centrale, orletto periferico iperdenso sottile o spesso o con nodularita' nel suo contesto, presenza di strie iperdense o diffusa iperdensita' nel tessuto adiposo perinodale. Nelle scansioni TC e' stata anche considerata la sede del carcinoma. Sono stati escludi dal nostro studio 70 pazienti in quanto considerati non operabili. Dei restanti 67 pazienti, 65 sono stati sottoposti a interento chirurgico, uno a mediastinoscopia, uno a mediastinoscopia seguita da intervento chirurgico. Sulla base dei segni TC precedentemente descritti, 46 pazienti sono stati definiti come N0, 6 pazienti come N1 e 15 come N. 2. In 44/46 pazienti N0 si e' riscontrata concordanza anatomo-patologica; 3 di questi 44 presentavano linfonodi con diametro superiore a un cm e densita' omogenea. (abstract truncated)

  7. Primary duodenal neoplasms: A retrospective clinico-pathological analysis

    Science.gov (United States)

    Bal, Amanjit; Joshi, Kusum; Vaiphei, Kim; Wig, JD

    2007-01-01

    AIM: To analyze the clinico-pathological spectrum of primary duodenal neoplasms. METHODS: A total of 55 primary duodenal neoplasms reported in the last 10 years after excluding ampullary and periampullary tumors were included in the study. Clinical details were noted and routine hematoxylin and eosin stained paraffin sections were studied for histological subtyping of the tumors. RESULTS: On histopathological examination primary duodenal neoplasms were categorized as: epithelial tumor in 27 cases (49.0%) including 10 cases of adenoma, 15 cases of adenocarcinoma, and 2 cases of Brunner gland adenoma; mesenchymal tumor in 9 cases (16.3%) consisting of 4 cases of gastrointestinal stromal tumor, 4 cases of smooth muscle tumor and I case of neurofibroma; lymphoproliferative tumor in 12 cases (21.8%), and neuroendocrine tumor in 7 cases (12.7%). CONCLUSION: Although non-ampullary/periampullary duodenal adenocarcinomas are rare, they constitute the largest group. Histopathological examination of primary duodenal tumors is important for correct histological subtyping. PMID:17373748

  8. Primary duodenal neoplasms:A retrospective clinico-pathological analysis

    Institute of Scientific and Technical Information of China (English)

    Amanjit Bal; Kusum Joshi; Kim Vaiphei; JD Wig

    2007-01-01

    AIM:To analyze the clinico-pathological spectrum of primary duodenal neoplasms.METHODS:A total of 55 primary duodenal neoplasms reported in the last 10 years after excluding ampullary and periampullary tumors were included in the study.Clinical details were noted and routine hematoxylin and eosin stained paraffin sections were studied for histological subtyping of the tumors.RESULTS:On histopathological examination primary duodenal neoplasms were categorized as:epithelial tumor in 27 cases(49.0%)including 10 cases of adenoma,15 cases of adenocarcinoma,and 2 cases of Brunner gland adenoma;mesenchymal tumor in 9 cases (16.3%)consisting of 4 cases of gastrointestinal stromal tumor,4 cases of smooth muscle tumor and I case of neurofibroma;lymphoproliferative tumor in 12 cases (21.8%),and neuroendocrine tumor in 7 cases(12.7%).CONCLUSION:Although non-ampullary/periampullary duodenal adenocarcinomas are rare,they constitute the largest group.Histopathological examination of primary duodenal tumors is important for correct histological subtyping.

  9. Pericoronal radiolucencies with significant pathology: Clinico-histopathologic evaluation

    Directory of Open Access Journals (Sweden)

    Sanjeev Anand

    2015-04-01

    Full Text Available Background: The purpose of the study was to correlate the provisional diagnosis of pericoronal radiolucencies associated with impacted, embedded, or unerupted teeth with the histopathologic diagnosis, and also to emphasize the importance of early detection for better diagnosis and management. Methods: This is a retrospective study involving 18 cases of pericoronal radiolucencies associated with unerupted, embedded, or impacted teeth whose data during 1-year period were retrieved, and were reviewed for clinical, radiological, and histopathologic data. Also, comparison and correlation of clinico-histopathologic diagnosis was made. Results: Of the 18 cases, 11 were provisionally diagnosed as dentigerous cyst and the remaining were diagnosed as ameloblastoma, odontogenic keratocyst, adenomatoid odontogenic tumor, and calcifying epithelial odontogenic cyst. Histopathologic diagnosis of the 18 cases showed varied results, with only 10% correlating with the provisional diagnosis. Conclusion: Although many pathological processes may present radiographically as pericoronal radiolucencies associated with unerupted teeth, the most common is the dentigerous cyst. Hence, it is crucial for the clinician to fully investigate all teeth that fail to erupt at the expected time, and promptly initiate appropriate assessment and management of suspected cystic lesions.

  10. Hirsutism: Clinico-investigative profile of 50 Indian patients

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    Sharma Nand

    2008-01-01

    Full Text Available Background: Despite worldwide prevalence of hirsutism studies on hirsutism in Indian patients are not many. Aims: This retrospective study was carried out to assess the clinico-investigative profile of patients presenting with hirsutism. Materials and Methods: Medical records of 82 hirsutism patients diagnosed consecutively during July 2005 to October 2007 were analyzed. Results: The complete data of 50 patients aged between 13 and 47 years were available. Fifty percent patients were aged 20 to 30 years. The average F-G score was 10.3 ± 2.46. Associated signs of hyperandrogenism were acne (64%, oligomenorrhea or menstrual irregularities (36%, androgenetic alopecia (16%, acanthosis nigricans (6% and seborrhea (4%. Polycystic ovaries were detected in 30% patients and 22% patients had elevated serum free testosterone levels. Family history of hirsutism was present in 18% patients. Conclusion: Hirsutism in Indian patients is not uncommon. Adolescent patients appear to be more concerned about hirsutism as compared to those in the older age group who were more often worried of late onset acne. All patients, however, were more concerned for facial hair than those on other body areas signifying that facial hair need to be given higher than current value in F-G score.

  11. Infezione da Borrelia burgdorferi: descrizione di un caso clinico atipico

    Directory of Open Access Journals (Sweden)

    Gino Ciarrocchi

    2005-06-01

    Full Text Available La borreliosi o Malattia di Lyme (ML è una malattia infettiva multisistemica causata da una spirocheta, Borrelia burgdorferi, trasmessa dal morso di una zecca del genere Ixodes.Viene descritto il caso clinico di una ragazza di venti anni. In un soggiorno estivo sul Monte Amiata, in Toscana, la giovane notò un arrossamento della pelle al fianco sinistro del corpo. Non osservò presenza della zecca nella zona di presumibile inoculo, da cui si sviluppò un eritema migrante (EM ad andamento centrifugo, fino a raggiungere un diametro di circa 10 centimetri. Nei giorni successivi e durante il follow up non sono mai comparsi sintomi collaterali generali riferibili ad astenia, febbricola, artralgie, malessere, né a carico di organi bersaglio. Dopo circa due settimane, persistendo l’EM, sono stati eseguiti esami sierologici specifici per Borrelia burgdorferi. Al riscontro positivo dei test ELISA e western-blot IgG e IgM, il clnico ha prescritto terapia antibiotica a base di Amoxicillina 2g/die per 20 giorni.Dopo 8-10 giorni di terapia è avvenuta la scomparsa completa dell’eritema. Viene mostrato l’andamento dei test sierologici al momento della diagnosi e durante il follow up, per un periodo di circa cinque mesi.

  12. SINONASAL MASSES: A CLINICO PATHOLOGICAL STUDY AT TERTIARY CARE CENTRE

    Directory of Open Access Journals (Sweden)

    Manish Kumar

    2014-07-01

    Full Text Available AIMS: To study the demography of sinonasal masses, clinical presentation, histopathological pattern and to correlate clinical findings with histopathology. MATERIALS AND METHODS: The present study entitled "Clinico pathological study of sinonasal masses" was carried out in 100 patients who attended the ENT OPD and inpatients in the Department of Otorhinolaryngology and Head and Neck Surgery, Gajra Raja Medical College, Gwalior (M.P. and associated with J.A. Group of Hospitals, Gwalior (M.P. during the period of July 2011 to June 2013 who were diagnosed as cases of sinonasal masses on the basis of clinical and histopathological examination. RESULTS: 32% patients were in age group 15-24 years, 64% were males. Most significant complaints were nasal obstruction and rhinorrhoea. Among 100 patients, nasal polyps were diagnosed in 83 patients, angiofibroma in 7 patients, septal angioma in 2 patients, rhinosporidiosis in 2 patients and one case each of capillary haemangioma, squamous cell carcinoma, angiosarcoma, transitional cell carcinoma and nasopharyngeal carcinoma was present. CONCLUSION: In the present study of masses in sinonasal cavity, most of the patients presented with trivial nasal symptoms, and there is always a possibility to miss the diagnosis if great care is not taken while examining the patient. The findings must be interpreted in light of great clinical suspicion, and complete ENT examination including radiologic and endoscopic studies.

  13. Melasma: A clinico-epidemiological study of 312 cases

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    Arun Achar

    2011-01-01

    Full Text Available Background: Melasma is an acquired increased pigmentation of the skin, characterized by gray-brown symmetrical patches, mostly in the sun-exposed areas of the skin. The pathogenesis is unknown, but genetic or hormonal influences with UV radiation are important. Aims: Our present research aims to study the clinico-epidemiological pattern and the precipitating or provocation factors in melasma. Materials and Methods: A total of 312 patients were enrolled for the study over a period of one year. Results: The mean age of patients with melasma was 33.45 years, ranging from 14 to 54 years. There was female preponderance with a female to male ratio of approximately 4 : 1. The mean age of onset was 29.99 years, with the youngest and oldest being 11 and 49 years, respectively. The patients sought medical treatment on an average of 3.59 years after appearance of melasma. About 55.12% of our patients reported that their disease exacerbated during sun exposure. Among 250 female patients, 56 reported pregnancy and 46 reported oral contraceptive as the precipitating factors. Only 34 patients had given history of exacerbation of melasma during pregnancy. A positive family history of melasma was observed in 104 (33.33% patients. Centrofacial was the most common pattern (55.44% observed in the present study. Wood light examination showed the dermal type being the most common in 54.48% and epidermal and mixed were seen in 21.47% and 24.03% of the cases, respectively. We tried to find an association with endocrinal diseases and observed that 20 of them had hypothyroidism. Conclusion: The exact cause of melasma is unknown. However, many factors have been implicated in the etiopathogenesis of this disorder. Here we try to identify the causative factors and provocation to develop melasma.

  14. MELASMA: A CLINICO-EPIDEMIOLOGICAL STUDY OF 312 CASES

    Science.gov (United States)

    Achar, Arun; Rathi, Sanjay K

    2011-01-01

    Background: Melasma is an acquired increased pigmentation of the skin, characterized by gray-brown symmetrical patches, mostly in the sun-exposed areas of the skin. The pathogenesis is unknown, but genetic or hormonal influences with UV radiation are important. Aims: Our present research aims to study the clinico-epidemiological pattern and the precipitating or provocation factors in melasma. Materials and Methods: A total of 312 patients were enrolled for the study over a period of one year. Results: The mean age of patients with melasma was 33.45 years, ranging from 14 to 54 years. There was female preponderance with a female to male ratio of approximately 4 : 1. The mean age of onset was 29.99 years, with the youngest and oldest being 11 and 49 years, respectively. The patients sought medical treatment on an average of 3.59 years after appearance of melasma. About 55.12% of our patients reported that their disease exacerbated during sun exposure. Among 250 female patients, 56 reported pregnancy and 46 reported oral contraceptive as the precipitating factors. Only 34 patients had given history of exacerbation of melasma during pregnancy. A positive family history of melasma was observed in 104 (33.33%) patients. Centrofacial was the most common pattern (55.44%) observed in the present study. Wood light examination showed the dermal type being the most common in 54.48% and epidermal and mixed were seen in 21.47% and 24.03% of the cases, respectively. We tried to find an association with endocrinal diseases and observed that 20 of them had hypothyroidism. Conclusion: The exact cause of melasma is unknown. However, many factors have been implicated in the etiopathogenesis of this disorder. Here we try to identify the causative factors and provocation to develop melasma. PMID:21965843

  15. [Clinico-pathological analysis of 45 parotid gland cysts].

    Science.gov (United States)

    Wang, Zhi-ming; Ye, Ming; Yang, Dong-sheng; Ma, Ying; Guan, Qiao-dan

    2016-04-01

    To discuss the clinical and pathological characteristics and management of parotid gland cyst. Forty-five resected samples of parotid gland tumors were selected from Shengjing Hospital of China Medical University from January 2000 to June 2014 whose postoperative pathological diagnosis were parotid gland cysts. The clinico-pathological characteristics in different types of parotid gland cysts were analyzed. Of 45 cases of parotid gland cyst, 25 were males, 20 were females. The median age was 51 years old. 21 cases were located on the left side of parotid gland, while 24 on the right side. The main clinical symptom was painless swelling in parotid gland region. The sizes varied from 0.8 cm×0.6 cm×0.5 cm to 10 cm×2.8 cm×0.6 cm. Nine cases were accompanied with pain, and 36 without. 4 cases were seen with lymph node enlargement, and 41 without pain. The main treatment modality was simple resection of cyst without any injury of facial nerve. No recurrence was seen after following up for 1-10 years. Of the 45 postoperative histopathological results, 29 cases (64.4%) were simple cysts, 9 cases (20.0%) were polycystic disease cysts, and 7 cases (15.6%) were lymphoepithelial cysts. Besides the above-stated pathological manifestations, some non-specific microscopic changes were accompanied with parotid gland cysts, including tumor-like hyperplasia of fibrous tissue, inflammations, calcifications, synovial cyst-like changes, foreign-body giant cell reactions and granulomatous changes. The main symptom of parotid gland cyst is progressive enlargement, and simple resection of cyst is the first-line treatment without facial nerve injury or reoccurrence. The main pathological classifications are simple cysts,lymphoepithelial cysts and polycystic disease cysts.

  16. Clinico-hemato-biochemical profile of dogs with liver cirrhosis

    Science.gov (United States)

    Elhiblu, M. A.; Dua, K.; Mohindroo, J.; Mahajan, S. K.; Sood, N. K.; Dhaliwal, P. S.

    2015-01-01

    Aim: The aim of this study was to determine the relevant tools in the diagnosis of liver cirrhosis in dogs. Material and Methods: A total of 140 dogs presented at Veterinary Teaching Hospital, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, showing clinical signs of hepatic insufficiency were subjected to clinico-hemato biochemical, urological, ultrasonographic (USG), and USG guided fine-needle biopsy examinations by standard methods. On the basis of these results, 6 dogs out of 140 dogs were found to be suffering from liver cirrhosis. Six clinically healthy dogs constituted the control group. Results: The dogs suffering from liver cirrhosis manifested inappetence, halitosis, abdominal distension, weight loss, melena, icterus, anemia, and neutrophilic leukocytosis with the left shift. Levels of hemoglobin, lymphocytes, packed cell volume, mean corpuscular volume, mean corpuscular Hb (MCH), and platelet count were significantly lower in liver cirrhosis group than control group while total leukocyte count, neutrophils, and MCH concentration were significantly higher. Glucose, total protein, albumin, A/G ratio, and fibrinogen were significantly lower, and creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, prothrombin time, and APTT were significantly higher than the control values. Ultrasound revealed diffuse increase in echogenicity with rounded and irregular liver margins. Cytological examination of the ascitic fluid and fine-needle aspiration biopsy of liver was not fruitful in the diagnosis of liver cirrhosis. Conclusions: Liver cirrhosis causes clinical and hemo-biochemical alterations, which require special consideration when treating diseased animals. USG, diffuse increase in echogenicity of liver, rounding and irregularity of liver margins and microhepatica were the consistent findings. It is suggested that USG along with hemo-biochemical alterations may be used as a diagnostic tool for liver cirrhosis

  17. Clinico-pathological profile of lung cancer in Uttarakhand

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    Rawat Jagdish

    2009-01-01

    Full Text Available Background: Lung cancer is one of the most aggressive and prevalent type of malignancy causing high morbidity and mortality. Tobacco smoking continues to be the leading cause of lung cancer worldwide. An increasing incidence of lung cancer has been observed in India. Objective: The aim of this study was to evaluate the clinico, a pathological profile of the lung cancer in hilly state of Uttrakhand. Materials and Methods: We performed a retrospective analysis of histopathologically proven cases of bronchogenic carcinoma admitted in our hospital from January 1998 to August 2005. Results: Our study included 203 patients with confirmed cases of lung cancer. Male to female ratio was 8.2:1. The common age group being 40-60 years, 9.86% of the patients were less than 40 years old age. Smoking was found to be the main risk factor in 81.77% patients. The most frequent symptom was cough (72.90% followed by fever (58.12%. The most common radiological presentation was mess lesion (46.31%. The most common histopathological type was squamous cell carcinoma (SCC (44.83% followed by adenocarcinoma (19.78% and small cell lung carcinoma (SCLC (16.75%. The majority patients (73.29% were diagnosed in the later stages of the disease (III B and IV. Conclusion: It was found out that SCC was the most frequent histopathological form. SCLC predominates below 40 year and SCC over 60 years of age. Smoking still remains the major risk factors in pathogenesis of lung cancer.

  18. Clinico-hemato-biochemical profile of dogs with liver cirrhosis

    Directory of Open Access Journals (Sweden)

    M. A. Elhiblu

    2015-04-01

    Full Text Available Aim: The aim of this study was to determine the relevant tools in the diagnosis of liver cirrhosis in dogs. Material and Methods: A total of 140 dogs presented at Veterinary Teaching Hospital, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, showing clinical signs of hepatic insufficiency were subjected to clinico-hemato biochemical, urological, ultrasonographic (USG, and USG guided fine-needle biopsy examinations by standard methods. On the basis of these results, 6 dogs out of 140 dogs were found to be suffering from liver cirrhosis. Six clinically healthy dogs constituted the control group. Results: The dogs suffering from liver cirrhosis manifested inappetence, halitosis, abdominal distension, weight loss, melena, icterus, anemia, and neutrophilic leukocytosis with the left shift. Levels of hemoglobin, lymphocytes, packed cell volume, mean corpuscular volume, mean corpuscular Hb (MCH, and platelet count were significantly lower in liver cirrhosis group than control group while total leukocyte count, neutrophils, and MCH concentration were significantly higher. Glucose, total protein, albumin, A/G ratio, and fibrinogen were significantly lower, and creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, prothrombin time, and APTT were significantly higher than the control values. Ultrasound revealed diffuse increase in echogenicity with rounded and irregular liver margins. Cytological examination of the ascitic fluid and fine-needle aspiration biopsy of liver was not fruitful in the diagnosis of liver cirrhosis. Conclusions: Liver cirrhosis causes clinical and hemo-biochemical alterations, which require special consideration when treating diseased animals. USG, diffuse increase in echogenicity of liver, rounding and irregularity of liver margins and microhepatica were the consistent findings. It is suggested that USG along with hemo-biochemical alterations may be used as a diagnostic tool for

  19. CLINICO EPIDEMIOLOGICAL AND BIOCHEMICAL PROFILE OF PATIENTS WITH MELASMA

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    Chandravathi

    2015-10-01

    Full Text Available BACKGROUND: The prevalence of melasma has been found to be 40% in females and 20% in males in Southeast Asian population. Heredity, exposure to sunlight, cosmetics eliciting phototoxic mechanisms, various hormones, pregnancy, and oral contracepti ve pill usage are the factors that may influence the causation of melasma. AIMS AND OBJECTIVES: To study the clinico epidemiological and biochemical profile of patients with melasma. SETTINGS AND DESIGN: A cross sectional descriptive study was done in 30 p atients with clinical diagnosis of mel a sma from June 2011 to June 2012. MATERIALS AND METHODS: Female patients above 18 years of age were included in the study. Patients with exogenous ochronosis and males were excluded from the study. Detailed clinical hi story was taken. Biochemical profile which included serum estradiol, progesterone, testosterone, leutinizing hormone (LH, follicle stimulating hormone (FSH, cortisol, adreno corticotrophic hormone (ACTH, T ri - iodothyronine (T3, thyroxine (T4 and thyroid stimulating hormone (TSH was done. STATISTICAL ANALYSIS: For all the statistical analysis SPSS statistical software , version 16.0 for windows (SPSS Inc, Chicago, IL, USA was used. Chi - square test was used for statistical significance. In all instances , p ≤ 0.05 was taken as statistically significant. RESULTS: Melasma was found to be more common in 40 - 50 years age group (46%, with a positive family history in 53.33%. Summer exacerbation was found in 80%. Positive correlation with pregnancy was found in 33.3% and with oral contraceptive pills in 46.6%. 60% of patients belonged to Fitzpatrick skin type IV. Malar pattern was found to be most common (58.3%. Thyroid abnormalities were found in 50%. Serum estradiol was low in 3 patients and progesterone was l ow in 2 out of 30 patients. FSH was high in 2 patients. LH, ACTH and cortisol were normal in all patients. CONCLUSION: Patients with Fitzpatrick skin type IV and V were more prone to

  20. ACGT: advancing clinico-genomic trials on cancer - four years of experience.

    Science.gov (United States)

    Martin, Luis; Anguita, Alberto; Graf, Norbert; Tsiknakis, Manolis; Brochhausen, Mathias; Rüping, Stefan; Bucur, Anca; Sfakianakis, Stelios; Sengstag, Thierry; Buffa, Francesca; Stenzhorn, Holger

    2011-01-01

    The challenges regarding seamless integration of distributed, heterogeneous and multilevel data arising in the context of contemporary, post-genomic clinical trials cannot be effectively addressed with current methodologies. An urgent need exists to access data in a uniform manner, to share information among different clinical and research centers, and to store data in secure repositories assuring the privacy of patients. Advancing Clinico-Genomic Trials (ACGT) was a European Commission funded Integrated Project that aimed at providing tools and methods to enhance the efficiency of clinical trials in the -omics era. The project, now completed after four years of work, involved the development of both a set of methodological approaches as well as tools and services and its testing in the context of real-world clinico-genomic scenarios. This paper describes the main experiences using the ACGT platform and its tools within one such scenario and highlights the very promising results obtained.

  1. Solitary bone plasmacytoma: An interesting case report with unusual clinico-cytological features.

    Science.gov (United States)

    Saksena, Annapurna; Mahajan, Nidhi; Agarwal, Shipra; Jain, Shyama

    2014-07-01

    Solitary bone plasmacytoma (SBP) is a rare entity characterized by localized proliferation of monoclonal plasma cells primarily occurring in the axial skeleton without systemic involvement. Involvement of the distal extremity is unusual. In the absence of typical clinical presentation, diagnosis may not be suspected clinico-radiologically; hence, fine-needle aspiration cytology may help in early and definitive diagnosis, hastening meticulous diagnostic workup and appropriate management of these patients. Intracytoplasmic crystalline inclusions (CI) have been reported in multiple myeloma and lymphoproliferative disorders. The present case highlights unusual clinico-cytological features of SBP with primary involvement of humerus, progression to tibia, and presence of extracellular and intracytoplasmic CI in plasma cells, a morphologic finding not reported in SBP earlier.

  2. [Clinico-functional features of mitral valve prolapse in young military men].

    Science.gov (United States)

    Gorbachenko, A V; Shalimov, P M

    2008-01-01

    One hundred and sixty-six young military man with mitral valve prolapse (MVP) aged 19.2+/-0.8 years were examined. Complex system approach to health status was applied to study clinico-functional features of this condition in young military men. The study found that clinico-functional manifestations of MVP in young military men reflected a multifocal character of dysadaptation during the first stages of military service. Conditions of professional military activity potentiate permanent progress of crisp prolapse as well as the severity of mitral regurgitation, structural and functional myocardial alterations, and myocardial electric instability increasing in the presence of abnormal cardiac chords under the influence of a prominent vegetative dysfunction. The reserve of the cardiorespiratory system and the entire organism in military men with MVP was lowered. The study registered inadequate hemodynamic responses to functional orthostatic test and physical load test, typical for hyperventilation syndrome.

  3. Clinico-epidemiological Study and Quality of Life Assessment in Melasma

    OpenAIRE

    Ravali Yalamanchili; Veeranna Shastry; Jayadev Betkerur

    2015-01-01

    Background: Melasma is one of the most common and distressing pigmentary disorders presenting to dermatology clinics. The precise cause of melasma remains unknown. It is notably difficult to treat and has a tendency to relapse. Its population prevalence varies according to ethnic composition, skin phototype, and intensity of sun exposure. Due to its frequent facial involvement, the disease has an impact on the quality of life of patients. Aims: To study the clinico-epidemiological pattern,...

  4. [Autosomal-recessive renal cystic disease and congenital hepatic fibrosis: clinico-anatomic case].

    Science.gov (United States)

    Rostol'tsev, K V; Burenkov, R A; Kuz'micheva, I A

    2012-01-01

    Clinico-anatomic observation of autosomal-recessive renal cystic disease and congenital hepatic fibrosis at two fetuses from the same family was done. Mutation of His3124Tyr in 58 exon of PKHD1 gene in heterozygous state was found out. The same pathomorphological changes in the epithelium of cystic renal tubules and bile ducts of the liver were noted. We suggest that the autopsy research of fetuses with congenital abnormalities, detected after prenatal ultrasonic screening, has high diagnostic importance.

  5. [Clinico-epidemiological characteristics of transient cerebral ischemia in the region of the Ukrainian Carpathian Mountains].

    Science.gov (United States)

    Buletsa, B A; Lupich, P P; Litvinova, L A

    1991-01-01

    Altogether 225 patients with transitory derangements of cerebral circulation (TDCC) underwent clinico-laboratory examinations. Arterial hypertension and cerebral atherosclerosis turned out to be among most frequently occurring factors of TDCC. The provoking factors included psychoemotional stress and drops of barometric pressure. The course and outcome of TDCC were greatly affected by an increase in blood concentration of catecholamines and thyroid hormones. The high concentration of triiodothyronine in the blood contributed to the development of cerebral stroke.

  6. Clinico-epidemiologichesky aspects of the mixed tick-borne infections in the endemic region

    Directory of Open Access Journals (Sweden)

    E. S. Aleshkovskaya

    2013-01-01

    Full Text Available Detection of clinico-epidemiological features of the mixed tick-borne infections – tick-borne Lyme disease and a human granulocytic anaplasmosis was the purpose of the conducted research. During the spring – summer period 146 patients with tick-borne borreliosis were surveyed. As a result at 45 (30,82% patients authentically diagnosed the mixed tick-borne infection. Features of clinical manifestations of a mixed tick-borne infection revealed: catarrhal phenomena (20%, liver defeats (33%, nephros (31, 7%, frequent secondary erythems (20%. Changes in haemogram defined: thrombocytopenia (42,2%, anemia (20%, leukopenia (13,3%.

  7. Peripheral odontogenic fibroma: a rare gingival neoplasm with clinico-pathological differential diagnosis.

    Science.gov (United States)

    Kumar, Rajesh; Jaiswal, Shradha; Sharma, Aanchal; Andhare, Vinod; Sabir, Husain

    2015-01-01

    The peripheral odontogenic fibroma (POdF) is a rare gingival neoplasm, characterised by relatively mature collagenous fibrous tissue and varying amounts of odontogenic epithelium. It can be described as a slow growing, firmly attached, solid and smooth gingival mass which may be present asymptomatically for years, which may cause displacement of adjacent teeth. The purpose of this article is to discuss a case of POdF, occurring in the maxillary anterior region, with detailed clinico-pathological differential diagnosis to clarify characteristic features of various gingival overgrowths to enhance easy identification.

  8. Behavioral symptoms after pallido-nigral lesions: a clinico-pathological case.

    Science.gov (United States)

    Adam, Julien; Baulac, Michel; Hauw, Jean-Jacques; Laplane, Dominique; Duyckaerts, Charles

    2008-01-01

    A 59-year-old patient presented with compulsive behaviors and lasting apathy after carbon monoxide intoxication. The apathy could be overcome by external stimulation (self-activation deficit). There was severe neuronal loss bilaterally in the anterior part of the pallidum and in the substantia nigra, pars reticulata. This first clinico-pathological case of a self-activation deficit illustrates the dissociation between motor and behavioral symptoms in lesions of the pallido-nigral complex, with the behavioral symptoms being related to lesions of the substantia nigra, pars reticulata and of the anterior part of the pallidum.

  9. [Clinico-epidemiological characteristics of mentally ill patients identified in the therapy department].

    Science.gov (United States)

    Liberman, Iu I; Ostroglazov, V G; Lisina, M A; Eliava, V N

    1990-01-01

    A clinico-epidemiological study was made of the incidence of mental diseases among the adult community visiting the therapeutic department of a city polyclinic. Mental patients registered at the PND (41.9 per 1000 population) underwent examinations. A large group of patients, mainly with borderline mental diseases, was additionally revealed (134.4 per 1000 population). Therefore, the total incidence of mental diseases among the adult community amounted to 176.3 per 1000 population. Both groups are compared in terms of the clinical syndromes, sex, age, and the level of social adaptation.

  10. Implementation of revised strategy of filaria control-baseline clinico-parasitological survey.

    Science.gov (United States)

    Patel, S; Rai, R N; Mishra, R N

    2000-06-01

    A clinico-epidemiological study of filariasis was carried out in Varanasi District in October and November, 1997 to generate baseline data for assessing the impact of Mass Drug Administration (MDA) in the district. Disease rate was found to be 6.6% (9.9% in males and 3.0% in females) and microfilaria rate was 5.3% (5.2% in males and 5.5% in females). Mean microfilaria density was found to be 9.86 per 20 Cu.mm blood. Genital manifestations (77.5%) outnumbered all other forms of clinical manifestations. Vector infectivity rate was found to be 0.93%.

  11. Screenings of lung cancer with low dose spiral CT: results of a three year pilot study and design of the randomised controlled trial Italung-CT; Screening della neoplasia polmonare con TC spirale a bassa dose: risultati di uno studio pilota triennale e disegno dello studio clinico randomizzato Italung-CT

    Energy Technology Data Exchange (ETDEWEB)

    Picozzi, Giulia [Firenze Univ., Firenze (Italy). Radiodiagnostica I-Dipartimento di Fisiopatologia Clinica; Paci, Enrico [Azienda Ospedaliera Universitaria di Careggi, Firenze (Italy). Unita' di Epidemiologia Clinica e Descrittiva Centro per lo Studio e la Prevenzione Oncologica; Lopes Pegna, Andrea [Azienda Ospedaliera Universitaria di Careggi, Firenze (Italy). U.O. Pneumologia] [and others

    2005-02-01

    multislice. Per la gestione clinico-radiologica dei noduli indeterminati riscontrati sono state seguite le raccomandazioni dell'Early Lung Cancer Action Project. Risultati: Complessivamente, sono stati riscontrati noduli indeterminati in 33 (55%) soggetti (60% alla TC di base, 24% al primo controllo annuale e 16% al secondo). Il nodulo di maggiori dimensioni aveva un diametro <5mm in 20 soggetti, in 10 dei quali il nodulo veniva rilevato all'esame di base. Quarantacinque (75%) soggetti hanno effettuato il primo controllo annuale e quarantadue (70%) il secondo. Sono stati riscontrati un tumore polmonare prevalente (1,6%) (carcinoma adenosquamoso), un tumore polmonare incidente (2,2%) (un tumore a piccole cellule, al primo controllo annuale), ed una localizzazione polmonare di un linfoma di Hodkin (al secondo controllo annuale). Inoltre un soggetto e' stato sottoposto ad intervento chirurgico polmonare per amartocondroma. Conclusioni: I risultati dello studio pilota sono sostanzialmente in linea con quelli di altri studi osservazionali su campioni di maggiori dimensioni e sono tali da giustificare ottimismo circa la affidabilita' dei risultati che saranno ottenuti nel braccio attivo dello studio randomizzato Italung-CT appena iniziato.

  12. [Leptospirosis-clinico-biological and therapeutical aspects-study of 256 cases].

    Science.gov (United States)

    Luca, Mihaela Cătălina; Dorobăţ, Carmen; Corcaci, Carmen; Scurtu, Roxana; Luca, V; Mihalache, Doina

    2002-01-01

    Leptospirosis is a zooantroponosis manifested as an infectious disease with a severe evolution, with liver and renal failure and hemorrhagic manifestation. The aim of this study was to present the clinico-biological investigation and the therapeutical aspects of 256 cases of leptospirosis admitted in the Infectious Diseases Hospital Iasi during 4 years (1998-2001). The diagnosis was based on the study of clinico-biological and therapeutical parameters (risk factors, fever, mialgia, headache, algic, eruptive, meningeal, hepatorenal, hemorrhagic syndromes with the serological evidence of the serotypes of leptospirosis); most of the cases were registered in 1998 (23% cases), in adults (31.2%) and male (75.22%). All the patients were serologic confirmed with leptospirosis (RAL and RFC), and L. icterohaemorhagiae was isolated most frequently. The standard anti-leptospirosis treatment was administered with favorable evolution; 6 deaths were registered from the severe forms of the disease. The leptospirosis is an emergent disease with the possibility of severe evolution in some forms, with liver and renal failure.

  13. Clinico-pathological correlates of cervical lymphadenopathy: a hospital based study.

    Science.gov (United States)

    Biswas, Gautam; Das, Anjan; Haldar, Dibakar; Mukherjee, Ankur; Dutta, Sirshak; Sinha, Ramanuj

    2013-07-01

    Neck is the most common site of peripheral lymph node enlargement and is very frequently encountered in oto-laryngological practice. This study was done to delineate distribution of clinico-demographic parameters in patients presenting with cervical lymphadenopathy in the otolaryngology out-patient department of a state hospital in India in a 1 year period and to correlate them with fine needle aspiration cytological diagnosis. Record-based cross sectional study in the department of Otolaryngology and department of Pathology, Calcutta National Medical College and Hospital, Kolkata. Case reports and cytological reports of 423 patients who underwent Fine Needle Aspiration Cytology (FNAC) of cervical lymph nodes between January 2009 and December 2009 were reviewed in relation to their demographic and clinical profiles. The cases were divided into three groups according to age and different parameters were described according to these groups. In the cyto-pathological diagnosis, tubercular lymph-adenitis was most prevalent diagnosis (45.4%). Among the metastatic secondaries, squamous cell carcinoma was most common (8.5%). Non-specific/reactive lymphadenitis was significantly more common in clinico-demographic perspectives of cervical lymphadenopathy in respect to their cytopathological diagnosis will help care giver practioners to detect/refer the respective cases early for investigations and treatment.

  14. Carcinoma ex pleomorphic adenoma in a Brazilian population: clinico-pathological analysis of 38 cases.

    Science.gov (United States)

    Mariano, F V; Noronha, A L F; Gondak, R O; Altemani, A M de A M; de Almeida, O P; Kowalski, L P

    2013-06-01

    Carcinoma ex pleomorphic adenoma (CXPA) is a rare tumour, with different prevalence rates reported among studies. Epidemiological studies of large series of CXPAs in developing countries are scarce. The aim of the present study was to describe Brazilian patients with CXPA; this was a retrospective study of 38 patients. Demographic and clinico-pathological features were evaluated. No preferential gender was found, and the mean age at diagnosis was 57.6 years. The most commonly involved site was the parotid, followed by the submandibular and the minor salivary glands. A prevalence of clinical stages III and IV was observed at diagnosis. The most common histological subtypes were salivary duct carcinoma, adenocarcinoma not otherwise specified, myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. Moreover, by invasive phase, most were frankly invasive carcinoma. Recurrence was observed in seven out of 24 patients with outcome information available, and all were invasive cases. All seven patients died of causes related to the disease. The distributions of cases according to age, gender, tumour location, and clinical stage were similar to those reported in the literature. Frankly invasive cases presented a worse prognosis. More information is needed to further our understanding of the clinico-pathological aspects of CXPA.

  15. Intestinal congenital/infantile fibrosarcoma: a new clinico-pathological entity?

    Science.gov (United States)

    Berrebi, Dominique; Fournet, Jean-Christophe; Boman, Françoise; Fabre, Monique; Philippe-Chomette, Pascale; Branchereau, Sophie; Fréneaux, Paul; Bouron-Dal Soglio, Dorothée; Michon, Jean; Peuchmaur, Michel

    2015-04-01

    Congenital/infantile fibrosarcoma (IFS) is a relatively rare form of fibrosarcoma diagnosed at birth or during early years of life and that differs from its adult counterpart because of a more favorable behavior. IFS is also known as cellular congenital mesoblastic nephroma, when it affects the kidney and is often but not always characterized by the ETV6-NTRK3 fusion transcript. We report herein the first series of an exceptional tumor of the small intestine occurring in newborns. The four patients shared a stereotyped clinico-pathological presentation with early and acute onset, intestinal perforation, and an infiltration by a highly cellular spindle cell tumor within the dilated intestinal wall exhibiting pathologic features typical of IFS. Molecular studies for the ETV6-NTRK3 translocation were negative in the three cases tested. Patients were treated by surgical wide resection alone and are alive and well (follow-up: 36 months-25 years). Thus, this new clinico-pathological entity, even with lack of documented evidence of the ETV6-NTRK3 translocation, should be included in the differential diagnosis of congenital bowel perforation or obstruction and may represent an intestinal counterpart of IFS.

  16. Gastric carcinoma at Tanta Cancer Center: A comparative retrospective clinico-pathological study of the elderly versus the non-elderly

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    Ahmed A. Zeeneldin

    2014-09-01

    Conclusions: Compared to the non-elderly, GC in the elderly has similar clinico-pathological characteristics and exhibits comparable outcomes with the same treatment options. Treatments should be tailored to each patient.

  17. Clinico-pathological analysis referring hemeoxygenase-1 in acute fibrinous and organizing pneumonia patients

    Directory of Open Access Journals (Sweden)

    Yu Hara

    2015-01-01

    We experienced two cases of subacute form AFOP for these 10 years and reviewed clinico-pathological characteristics. The average age was 62 years old and both were male. The etiology of both cases was idiopathic. The average PaO2/FIO2 ratio was 274.5 ± 84.1. The average levels of C-reactive protein and surfactant protein - A of the serum were elevated to 19.8 ± 6.3 mg/dL and 67.6 ± 15.8 ng/mL, respectively. Serum sialylated carbohydrate antigen levels were normal in both cases. The characteristic radiographic findings were bilateral consolidations and ground glass opacities. Lung biopsy specimens revealed fibrin balls and alveolitis with abundant cellular HO-1 expression. Steroid response was excellent and the pulmonary involvements absolutely disappeared for about 3 months.

  18. [Clinico-economical aspects of cardioversion of paroxysmal atrial fibrillation at phehospital stage and during hospitalization].

    Science.gov (United States)

    Bulanova, N A; Stazhadze, L L; Sidorenko, B A

    2012-01-01

    We carried out clinico-economical analysis of 2 tactics of rhythm restoration in patients with paroxysmal atrial fibrillation (AF) lasting less than 48 hours: cardioversion at prehospital stage with intravenous procainamide and inhospital cardioversion with any method. This retrospective study was based on the data from department of urgent aid of an outpatient clinic. The results showed that within 48 hours inhospital was a was more effective, safe, and more economically profitable compared with administration of procainamide at prehospital stage. Intravenous procainamide resulted in effective cardioversion in 70.6% of patients. It was associated with arterial hypotension and proarrhythmogenic action in 14,7% of cases. Patients with effective cardioversion with procainamide had lesser mean values of left ventricular anterior-posterior dimension (echocardiography) and shorter duration of arrhythmia.

  19. Pulmonary Alveolar Microlithiasis "Stone Lungs": A Case of Clinico-Radiological Dissociation.

    Science.gov (United States)

    Chu, Andrew; Shaharyar, Sameer; Chokshi, Binna; Bhardwaj, Nikhil

    2016-08-24

    Pulmonary alveolar microlithiasis (PAM) is a rare infiltrative lung disease characterized by deposition of spherical calcium phosphate microliths called calcospherites within the alveoli. PAM was first described by Friedrich in 1856 and then by Harbitz in 1918. The disease pathogenesis is based on mutations in the SLC34A2 gene that encodes for the Type IIb sodium-phosphate cotransporter. The majority of the patients are diagnosed at an early age, usually between the ages of 20 and 40 years. The hallmark of this disease is a striking dissociation between the radiological findings and the mild clinical symptoms.  We report a case of 35-year-old woman who presented post-motor vehicle accident with back pain and with minimal dyspnea on exertion. The final diagnosis was made after computed tomography and lung biopsy. The present case exhibits the remarkable clinico-radiological dissociation with complete calcification of the lungs on radiographic images with a relatively mild clinical presentation.

  20. Clinico-radiological findings of neuro-Behcet's syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Tajima, Yasutaka; Homma, Sanae; Sinpo, Kazunori; Moriwaka, Fumio; Tashiro, Kunio (Hakodate City Hospital, Hokkaido (Japan)); Maruo, Yasunori

    1994-03-01

    We examined 21 cases of Neuro-Behcet's syndrome in detail, and present here their clinico-radiological characteristics. Clinically, signs of pyramidal tract and meningeal irritation were frequently observed. In contrast to previous reports, our study demonstrated a near equal frequency in the occurrence of focal cerebral lesions and that of focal brain stem lesions. Notably, our results showed that the atrophy of both the cerebrum and the brain stem was often observed, indicating the presence of continuous disease activity in the central nervous system (CNS). In accordance with the high frequency of meningeal irritation signs, all of our cases exhibited pleocytosis in the cerebrospinal fluid (CSF). These results indicated the possibility that chemical mediators secreted from infiltrating cells in the CSF may somehow inflict damage to the CNS in Neuro-Behcet's syndrome. (author).

  1. Radiological protection; Proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Azorin N, J. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Division de Ciencias Basicas e Ingenieria, Av. San Rafael Atlixco 186, Col. Vicentina, 09340 Mexico, D. F. (Mexico); Azorin V, J. C. [Universidad de Guanajuato, Campus Leon, Division de Ciencias e Ingenieria, Loma del Bosque 103, Lomas del Campestre, 37150 Leon de los Aldama, Guanajuato (Mexico)

    2010-07-01

    This work is directed to all those people related with the exercise of the radiological protection and has the purpose of providing them a base of knowledge in this discipline so that they can make decisions documented on technical and scientist factors for the protection of the personnel occupationally exposed, the people in general and the environment during the work with ionizing radiations. Before de lack of a text on this matter, this work seeks to cover the specific necessities of our country, providing a solid presentation of the radiological protection, included the bases of the radiations physics, the detection and radiation dosimetry, the radiobiology, the normative and operational procedures associates, the radioactive wastes, the emergencies and the transport of the radioactive material through the medical and industrial applications of the radiations, making emphasis in the relative particular aspects to the radiological protection in Mexico. The book have 16 chapters and with the purpose of supplementing the given information, are included at the end four appendixes: 1) the radioactive waste management in Mexico, 2-3) the Mexican official standards related with the radiological protection, 4) a terms glossary used in radiological protection. We hope this book will be of utility for those people that work in the investigation and the applications of the ionizing radiations. (Author)

  2. Clinico-epidemiological profile of tobacco users attending a tobacco cessation clinic in a teaching hospital in Bangalore city

    OpenAIRE

    George D′Souza; Dorothy P Rekha; Priya Sreedaran; Srinivasan, K.; Mony, Prem K

    2012-01-01

    Background: Tobacco-attributable mortality in India is estimated to be at least 10%. Tobacco cessation is more likely to avert millions of deaths before 2050 than prevention of tobacco use initiation. Objective: To describe the clinico-epidemiological profile of attendees of a tobacco cessation clinic in a teaching hospital in Bangalore city. Materials and Methods: A descriptive study of 189 attendees seen over 2 years in the Tobacco Cessation Clinic of a tertiary-care teaching hospital in Ba...

  3. Modified Mason's vertical banded gastroplasty. Radiological follow-up 322 patients with morbid obesity; Ruolo della radiologia nella valutazione dei pazienti affetti da obesita' patologica sottoposti a gastroplastica verticale secondo Mason modificata. Studio di 322 casi

    Energy Technology Data Exchange (ETDEWEB)

    Monteduro, F.; Cappello, I.; Pezzi, A.; Spagnol, A. [Bologna Univ., Bologna (Italy). Policlinico S. Orsola, Servizio Radiologia 2; Ghetti, A. [Bologna Univ., Bologna (Italy). Clinica Chirurgica 2

    1999-12-01

    the neo stomach and permit to correlate the pouch volume with weight loss. [Italian] La gastroplastica verticale secondo Mason rappresenta una delle tecniche piu' utilizzate nel trattamento dell'obesita' patologica in quanto ha semplice esecuzione, buoni risultati e scarsa incidenza di complicanze a distanza. Nel presente lavoro venogno presentati i risultati del controllo radiologico postoperatorio condotto su 322 pazienti sottoposti a gastroplastica verticale secondo Mason modificata. In 322 pazienti sottoposti a gastroplastica verticale secondo Mason modificata sono state valutate mediante studio radiologico con pasto semiliquido e tecnica con mdc semplice le caratteristiche morfologiche, funzionali e volumetriche della tasca gastrica e le eventuali complicanze dell'intervento. Di questi 322 pazienti 272 erano femmine con eta' compresa tra 17 e 69 anni (media 37) e 50 maschi con eta' compresa tra 19 a 64 anni (media 36); il peso medio era di 124 kg (con intervallo da 78 a 218). Solo nei pochi casi in cui e' risultata necessaria la valutazione dettagliata della mucosa del neostomaco e' stato utilizzato il doppio mdc on minime dosi di polvere effervescente. La valutazione e' stata effettuata dopo uno e 12 mesi dall'intervento. Controlli al di fuori di questo protocollo sono stati effettuati solo su precisa indicazione clinica per sospetta insorgenza di complicanze compreso il non adeguato calo ponderale. Nella nostra serie si sono osservate 9 complicanze precoci: edema persistente dello pseudopiloro (8 casi) ed emorragia endogastrica (un caso) e 8 complicanze tardive: aderenza dello pseudopiloro al letto della colecisti (un caso), formazione di pseudo-diverticolo della parete posteriore del neostomaco (un caso), orizzontalizzazione del neostomaco (4 casi), deiscenza della sutura lineare (2 casi). In 305 pazienti non si e' avuta nessuna complicanza con calo ponderale soddisfacente e volumetria del neostomaco uno e

  4. Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

    Directory of Open Access Journals (Sweden)

    Tsang Percy CK

    2006-08-01

    Full Text Available Abstract Background Epigenetic gene silencing is one of the major causes of carcinogenesis. Its widespread occurrence in cancer genome could inactivate many cellular pathways including DNA repair, cell cycle control, apoptosis, cell adherence, and detoxification. The abnormal promoter methylation might be a potential molecular marker for cancer management. Methods For rapid identification of potential targets for aberrant methylation in gynecological cancers, methylation status of the CpG islands of 34 genes was determined using pooled DNA approach and methylation-specific PCR. Pooled DNA mixture from each cancer type (50 cervical cancers, 50 endometrial cancers and 50 ovarian cancers was made to form three test samples. The corresponding normal DNA from the patients of each cancer type was also pooled to form the other three control samples. Methylated alleles detected in tumors, but not in normal controls, were indicative of aberrant methylation in tumors. Having identified potential markers, frequencies of methylation were further analyzed in individual samples. Markers identified are used to correlate with clinico-pathological data of tumors using χ2 or Fisher's exact test. Results APC and p16 were hypermethylated across the three cancers. MINT31 and PTEN were hypermethylated in cervical and ovarian cancers. Specific methylation was found in cervical cancer (including CDH1, DAPK, MGMT and MINT2, endometrial cancer (CASP8, CDH13, hMLH1 and p73, and ovarian cancer (BRCA1, p14, p15, RIZ1 and TMS1. The frequencies of occurrence of hypermethylation in 4 candidate genes in individual samples of each cancer type (DAPK, MGMT, p16 and PTEN in 127 cervical cancers; APC, CDH13, hMLH1 and p16 in 60 endometrial cancers; and BRCA1, p14, p16 and PTEN in 49 ovarian cancers were examined for further confirmation. Incidence varied among different genes and in different cancer types ranging from the lowest 8.2% (PTEN in ovarian cancer to the highest 56

  5. Sporadic late-onset nemaline myopathy: clinico-pathological characteristics and review of 76 cases.

    Science.gov (United States)

    Schnitzler, Lukas J; Schreckenbach, Tobias; Nadaj-Pakleza, Aleksandra; Stenzel, Werner; Rushing, Elisabeth J; Van Damme, Philip; Ferbert, Andreas; Petri, Susanne; Hartmann, Christian; Bornemann, Antje; Meisel, Andreas; Petersen, Jens A; Tousseyn, Thomas; Thal, Dietmar R; Reimann, Jens; De Jonghe, Peter; Martin, Jean-Jacques; Van den Bergh, Peter Y; Schulz, Jörg B; Weis, Joachim; Claeys, Kristl G

    2017-05-11

    Sporadic late-onset nemaline myopathy (SLONM) is a rare, late-onset muscle disorder, characterized by the presence of nemaline rods in muscle fibers. Phenotypic characterization in a large cohort and a comprehensive overview of SLONM are lacking. We studied the clinico-pathological features, treatment and outcome in a large cohort of 76 patients with SLONM, comprising 10 new patients and 66 cases derived from a literature meta-analysis (PubMed, 1966-2016), and compared these with 15 reported HIV-associated nemaline myopathy (HIV-NM) cases. In 6 SLONM patients, we performed a targeted next-generation sequencing (NGS) panel comprising 283 myopathy genes. SLONM patients had a mean age at onset of 52 years. The predominant phenotype consisted of weakness and atrophy of proximal upper limbs in 84%, of proximal lower limbs in 80% and both in 67%. Other common symptoms included axial weakness in 68%, as well as dyspnea in 55% and dysphagia in 47% of the patients. In 53% a monoclonal gammopathy of unknown significance (MGUS) was detected in serum. The mean percentage of muscle fibers containing rods was 28% (range 1-63%). In 2 cases ultrastructural analysis was necessary to detect the rods. The most successful treatment in SLONM patients (all with MGUS) was autologous peripheral blood stem cell therapy. A targeted NGS gene panel in 6 SLONM patients (without MGUS) did not reveal causative pathogenic variants. In a comparison of SLONM patients with and without MGUS, the former comprised significantly more males, had more rapid disease progression, and more vacuolar changes in muscle fibers. Interestingly, the muscle biopsy of 2 SLONM patients with MGUS revealed intranuclear rods, whereas this feature was not seen in any of the biopsies from patients without paraproteinemia. Compared to the overall SLONM cohort, significantly more HIV-NM patients were male, with a lower age at onset (mean 34 years). In addition, immunosuppression was more frequently applied with more

  6. 'Top of the basilar' syndrome. Clinico-radiological evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Masaharu; Kuroda, Ryotaro; Nakatani, Jiro; Watanabe, Masaru; Akai, Fumiharu; Ioku, Masahiko

    1988-06-01

    Seventeen patients (age 23 - 81) having the ''top of the basilar'' syndrome were the subjects of this study. They were evaluated clinico-radiologically. The diagnosis of this syndrome was made by computerized tomography. The infarcted lesions of each patient were widely distributed in many areas among the thalamus, midbrain, pons, cerebellum, and occipital lobe. Both the thalami were involved in 8 patients. When the thalamus was involved bilaterally, the low density areas of both the thalami were demonstrated to be almost the same in size and symmetric in localization by computerized tomography, showing a characteristic pattern. Further, magnetic resonance imaging could reveal small lesions in the brain stem minutely. Angiography revealed that stenosis or occlusion was within the circle of 2 cm in diameter surrounding the five-forked road of the top of the basilar artery in 84.6 %. Recanalization of the occluded artery occurred in 61.5 %, which suggests that the embolism plays an important role in appearance of this syndrome. In spite of frequent recanalization hemorrhagic infarction never occurred. The prognosis was very poor.

  7. [Necrotic myelopathies and neoplastic pathologie. Three clinico-pathological cases (author's transl)].

    Science.gov (United States)

    Gray, F; Hauw, J J; Escourolle, R; Castaigne, P

    1980-01-01

    Three clinico-pathological cases of necrotic myelopathies with a distant malignancy are presented. Two cases had a lymphosarcoma and one case a prostatic carcinoma. They were compared to 13 well studied other cases collected in the literature. These myelopathies were related to solid visceral tumours in 8 cases and to lymphomas in 5 cases. The disease could be individualized on clinical grounds (flaccid paraplegia with bladder and bowell incontinence and sensory loss without clear-cut upper boundary developing over a few weeks with normal CSF and fast impairement of general condition), and, on pathological features. It is characterized by one or several spinal cord necrosis areas, often asymetrical, involving mostly white matter, without any vascular topography. Axons are involved as well as myelin sheats. There is mild inflammation and no specific vascular alteration. There is no metastases in the cord, meninges, vertebral column or nerve root. No vascular occlusion is found. The mechanism of the disease is unknown. The frequent occurence of lymphomas could suggest the presence of immunopathological factors.

  8. Clinico-allergological pattern of allergic contact dermatitis among 70 Indian children

    Directory of Open Access Journals (Sweden)

    Sarma Nilendu

    2010-01-01

    Full Text Available Background: Rapid urbanization, westernization of lifestyles, poor quality of objects available and extremely relaxed vigilance on adherence to ′product safety guidelines′ make any developing country like India highly susceptible to allergic contact dermatitis (ACD even in children. There has been no previous attempts to assess the magnitude of childhood ACD in India. Aims: To assess the clinico-allergological profile of ACD in Indian children. Methods: All consecutive children up to 15 completed years of age who were patch tested over the last 3 years were analyzed from the records. Results: A total of 70 children were studied (average age of disease onset 8.39±3.59 years [SD], range 1-15 years and average age of presentation 10.8 ± 2.99 years [SD], range 5-15 years. Relevant allergy was noted in 48.6% of the patients. Age and sex had no significant role on the prevalence of ACD. Common allergens were paraben (43%, potassium dichromate (27% and fragrance mix (26%. Most relevant allergens were potassium dichromate, paraben and fragrance. Foot was the most commonly involved site (25.7% of patients. Atopy was present in 18 patients (25.7%. A total of 22 irritant reactions were noted in 13 patients. Conclusion: This study reflects the current status of childhood ACD of this region.

  9. Efficacy of crystallization test for screening of oral squamous cell carcinoma with clinico-pathological correlation

    Directory of Open Access Journals (Sweden)

    Sachin C Sarode

    2013-01-01

    Full Text Available Aim: To determine the efficacy of crystallization test for screening oral squamous cell carcinoma (OSCC with clinico-pathologic correlation. Materials and Methods: Fifty patients of OSCC and 30 healthy individuals were selected. One drop of blood was collected into 1 cc of doubled distilled water at room temperature to give a final dilution of 6% hemolyzed blood. 0.1 to 0.2 cc of blood sample was then subjected to crystallization test using 10% cupric chloride solution. Results: In healthy control group, the typical pattern was an eccentrically placed center of gravity with needles arranged in radiating fashion, while in OSCC group, there was ′transverse form′ (TF formation. The sensitivity and specificity of this test was found to be 96% and 96.66%, respectively. The positive and negative predictive values were found to be 97.96% and 98.55%, respectively. The mean TF frequency was found to be increasing from grade I (3.20 ± 1.5% to grade II (653 ± 2.23% and difference was statistically significant (P = 0.0001. However, there was no correlation between mean TF frequency and TNM stages of OSCC. Conclusion: Crystallization test is a simple, reliable, economical, less time-consuming, and less invasive screening procedure, which can be used for early detection of OSCC.

  10. Tegmental-type primary pontine hemorrhage with mesencephalic extension. Clinico-CT-anatomic correlations

    Energy Technology Data Exchange (ETDEWEB)

    Goto, Noboru; Ishikawa, Hiroshi; Kaneko, Mitsuo; Tanaka, Keisei

    1983-06-01

    In nine autopsy cases of tegmental-type primary pontine hemorrhage, two cases with a mesencephalic extension which was not accurately diagnosed symptomatologically, but which was clearly detected on CT films, were found. Correlative clinico-CT-anatomic reports on this kind of pontine hemorrhage have not been included in the literature. The two patients were both females, 73 and 53 years old. Both were hypertensive and under medical care. They showed disturbances of consciousness and respiration, pin-point pupils, fixed eyes in the midposition, right hemiplegia, right extensor plantar response, etc., but both responded well to painful stimuli on the left half of the body. CT examinations detected a continuous high-density area in the left-sided tegmentum of the pons and midbrain. They died 9 and 21 days later respectively. With the help of an electronic image analyser, a great volume of hematoma was measured in the postmortem brainstem in these cases (17 ml and 14 ml). Precise analyses of the correlations among clinical symptomatology, CT, and anatomical findings, and histological examinations were carried out in an attempt to find the pathogenesis of this disease. In the diagnosis of tegmental-type primary pontine hemorrhage, attention should be paid to a possible mesencephalic involvement as one of the modes of hematoma extension, although it may be rather rare.

  11. Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series.

    Science.gov (United States)

    Martínez-Mata, Guillermo; Mosqueda-Taylor, Adalberto; Carlos-Bregni, Roman; de Almeida, Oslei Paes; Contreras-Vidaurre, Elisa; Vargas, Pablo Agustin; Cano-Valdéz, Ana María; Domínguez-Malagón, Hugo

    2008-06-01

    The aim of this study was to analyze the clinico-pathological and immunohistochemical features of 62 cases of odontogenic myxoma (OM) diagnosed in three Oral Pathology Diagnostic Services in Latin America, as well as to describe the ultrastructural features of three of these cases. OM showed a wide age range (9-71 years), with a mean of 27.97 yr (SD: 11.01) and a male to female ratio of 1:2.2. Mandible was affected in 37 cases (59.6%) and maxilla in 25 (40.4%), with 61.3% located in the posterior region. Thirty-nine cases (62.9%) were multilocular and 23 (37.1%) unilocular. Size ranged from 1 to 13 cm, (mean: 5.2 cm). Thirty-seven multilocular (54.8%) and 6 unilocular lesions (26%) were larger than 4 cm (pNSE and CD68, and showed a low index of expression of Bcl2 and ki-67 proteins (products. However, further investigations are needed to better understand the participation of these elements in this particular neoplasm.

  12. Progressive anterior operculum syndrome due to FTLD-TDP: a clinico-pathological investigation.

    Science.gov (United States)

    Otsuki, Mika; Nakagawa, Yoshitsugu; Mori, Fumiaki; Tobioka, Hirotoshi; Yoshida, Hideaki; Tatezawa, Yoshiharu; Tanigawa, Toshio; Takahashi, Ikuko; Yabe, Ichiro; Sasaki, Hidenao; Wakabayashi, Koichi

    2010-07-01

    Pathological investigation of progressive anterior operculum syndrome has rarely been reported. We describe clinico-pathological findings in a patient with progressive anterior operculum syndrome. A 74-year-old right-handed man had noticed speech and swallowing difficulties 1 year previously. Neurological examinations showed no abnormality other than a slight limitation of upward gaze and slow tongue movement without fibrillation. We investigated the patient using neuroimaging and neuropsychological examinations and observed him for 2 years until his death, at which point we obtained pathological findings. The patient's facial and masseteric muscles seemed hypotonic with drooling, but he could laugh and yawn normally, showing automatic voluntary dissociation. Palatal and pharyngeal reflexes were normal. Magnetic resonance imaging showed cortical atrophy in the temporal lobes bilaterally. (123)IMP single photon emission computed tomography and positron emission tomography showed decreased blood flow and activity in the frontotemporal lobes, predominantly on the left side. Neuropsychological examinations showed no aphasia, dementia or other neuropsychological abnormality. Intubation fiberscopy, laryngoscopy and video fluorography showed no abnormality. After 6 months his anarthria and dysphagia became aggravated. He died of aspiration pneumonia 2 years after onset. Postmortem examination revealed neuronal degeneration with TDP-43-positive inclusions in the frontal, temporal and insular cortices, consistent with frontotemporal lobar degeneration with TDP inclusions (FTLD-TDP). However, neuronal loss with gliosis was more prominent in the inferior part of the motor cortices, bilaterally. Progressive anterior operculum syndrome could be classified as a variant of FTLD-TDP.

  13. Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings.

    Science.gov (United States)

    Mizukami, Keijiro; Shoubudani, Tomoaki; Nishimoto, Seira; Kawamura, Ryuta; Yabuki, Akira; Yamato, Osamu

    2012-06-01

    Trapped neutrophil syndrome (TNS) is an autosomal recessive inherited neutropenia known in Border Collies since the 1990's. Recently, the causative mutation has been identified in the canine VPS13B gene and a DNA-based diagnosis has now become available. The present paper describes clinical and clinico-pathologic findings in a Border Collie with TNS that was molecularly diagnosed for the first time in Japan. In a 10-week-old male Border Collie with microgenesis and symptoms related to recurrent infections, a hematological examination revealed severe leukopenia due to neutropenia, suggesting the dog to be affected by inherited neutropenic immunodeficiency. Direct DNA sequencing demonstrated that the dog was homozygous for the causative mutation of TNS and both its parents were heterozygous carriers. In addition, a simple and rapid polymerase chain reaction-based length polymorphism analysis coupled with microchip electrophoresis was developed for the genotyping of TNS. This assay could discriminate clearly all genotypes, suggesting that it was suitable for both individual diagnosis and large-scale surveys for prevention.

  14. Clinico-epidemiological and socio-behavioral study of people living with HIV/AIDS

    Directory of Open Access Journals (Sweden)

    Khan M

    2010-01-01

    Full Text Available Although India is in the grip of HIV/AIDS epidemic, not much information is available on clinico-epidemiological and socio-behavioral aspects of people living with HIV/AIDS (PLWHA. This study analyzed these features using standard methodologies in 82 HIV sero-positives, AIDS patients attending ART clinic of three major government hospitals of Delhi. Majority of the patients (73% were found to be young (<40 years and married (79%. As high as 91.5% came from low socio-economic class and more than 95% acquired HIV transmission through heterosexual routes. A large proportion (63% of these patients reported an extremely high level of anxiety, moderate level of stress and a borderline level of clinical depression. While most of the patients (72% were well-adjusted with the ART, the rest of the patients reported difference in making adjustment with the treatment schedules. The study suggests that counseling and supportive therapy could play a pivotal role in controlling anxiety, stress, depression and rehabilitating people with HIV/AIDS.

  15. Trifurcation of superficial brachial artery: a rare case with its clinico-embryological implications.

    Science.gov (United States)

    Gupta, N; Anshu, A; Dada, R

    2014-01-01

    Literatures on vasculature of upper limbs are crammed with reports of distinctly deviant version of normally prevalent vessels having modified origins, altered branching and odd courses. A unique anatomical variation in vascular pattern was observed during routine dissection of right upper limb in gross anatomy laboratory, AIIMS, New Delhi, India. The brachial artery was placed superficial to median nerve in the arm and therefore it was called superficial brachial artery. In the cubital fossa, 2.8 cm distal to intercondylar line of elbow joint, this superficial brachial artery terminated by trifurcation into radial, common interosseous and ulnar branches. Strikingly the ulnar branch, after its origin ran superficially over the median nerve and epitrochlear superficial flexor group of muscles of forearm in succession for the initial third of its course in the forearm, consequently it was addressed as superficial ulnar artery. The existence of superficial brachial artery in place of normal brachial artery, its termination by trifurcation into radial, common interosseous and superficial ulnar arteries with remarkably different courses, leads to confusing disposition of structures in the arm, cubital fossa and in the forearm and collectively makes this myriad of anatomical variations even rarer. The clinico-embryological revelations for combination of these unconventional observations, apprises and guides the specialized medical personnel attempting blind and invasive procedures in brachium and ante-brachium. This case report depicts the anatomical perspective and clinical implications on confronting a rare variant vasculature architecture pattern of upper limb.

  16. Clinico-pathological characteristics of different types of immunodeficiency-associated smooth muscle tumours.

    Science.gov (United States)

    Hussein, Kais; Rath, Berenice; Ludewig, Britta; Kreipe, Hans; Jonigk, Danny

    2014-09-01

    Rare Epstein-Barr virus (EBV)+ smooth muscle tumours (SMT) manifest typically under immunosuppression. Three major subtypes are known: human immunodeficiency virus-associated (HIV-SMT), after transplantation (PTSMT) or associated with congenital immunodeficiency syndromes (CI-SMT). So far, there are no analyses which compare the clinico-pathological characteristics of all three subtypes. Case reports and case series on these three tumour types were collected (1990-2012). Meta-data analysis was performed for identification of similarities and differences. A total of 73 HIV-SMT, 66 PTSMT and 9 CI-SMT were evaluated. There was a slight female predominance (55-67%). Children were affected nearly equally in HIV-SMT (33%) and PTSMT (35%), while all CI-SMT occurred in children. HIV-SMT manifested preferentially in the central nervous system, gut/liver, skin, lungs/larynx/pharynx and adrenal glands. PTSMT were predominantly found in the liver, lungs/larynx/pharynx, gut/spleen and brain. CI-SMT were often found in lungs/larynx, brain, liver, adrenal glands and spleen. Antecedent EBV+ lymphoproliferations manifested more often in PTSMT. In all three tumour subtypes, survival analyses did not show any significant differences regarding surgical therapeutic approaches, the occurrence of multiple tumours, tumour size or sarcoma-like histological features. HIV-SMT had the poorest overall survival, which might be attributed to HIV-associated infectious complications.

  17. Viral aetiology and clinico-epidemiological features of acute encephalitis syndrome in eastern India.

    Science.gov (United States)

    Rathore, S K; Dwibedi, B; Kar, S K; Dixit, S; Sabat, J; Panda, M

    2014-12-01

    This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aetiology was identified in 91 (17·2%) cases. Herpes simplex virus (HSV; types I or II) was most common (16·1%), followed by measles (2·6%), Japanese encephalitis virus (1·5%), dengue virus (0·57%), varicella zoster virus (0·38%) and enteroviruses (0·19%). Rash, paresis and cranial nerve palsies were significantly higher (P Case-fatality rates were 10·9% and 6·2% in AES cases with and without viral aetiology, respectively. Simultaneous infection of HSV I and measles was observed in seven cases. This report provides the first evidence on viral aetiology of AES viruses from eastern India showing dominance of HSV that will be useful in informing the public health system.

  18. An analysis of clinico-pathologic features of intraductal papillary mucinous neoplasm of the pancreas

    Institute of Scientific and Technical Information of China (English)

    LOU Wenhui; JIN Dayong; WANG Dansong; XU Xuefeng; KUANG Tiantao; QIN Xinyu

    2007-01-01

    The natural history and clinical manifestation of resected intraductal papillary mucinous neoplasm(IPMN)of the pancreas were elucidated,and based on this,a retrospective pancreatic database was reviewed to identify patients with IPMN who were surgically managed in our department from 1999 to June 2006.Pathologic rereview of each case was performed,and the clinico-pathologic features were examined.Student's T test and X2 analysis were used to identify factors associated with malignancy.Fifty-one patients were identified.There were 33 males and 18 females.One patient's pancreas was unresectable,two patients underwent a total pancreatectomy,42 patients had a pancreatecoduodenectomy and five patients had distal pancreatectomy.Main-duct type carcinoma was identified in 24 patients;branch-duct type in 15 patients,and mixed type in 12 patients.Invasive carcinoma was present in 35 patients.Weight loss and iaundice occurred more commonly in the invasive group.The average serum CA19-9 level was significantly higher in the invasive group(1542μ vs 94.5μ).The average diameter of the pancreatic duct was also wider in the invasive group (8.7 mm vs 4.3 mm).Significant predictors of malignant IPMNS included weight loss,iaundice,a high level of serum CA19-9.a large pancreatic duct and main-duct type carcinoma.

  19. Clinico-epidemiological study of near-hanging cases - An investigation from Nepal.

    Science.gov (United States)

    Atreya, Alok; Kanchan, Tanuj

    2015-07-01

    Hanging is one of the commonest methods of suicide. Epidemiological data of near-hanging patients from Nepal is limited. The present research from Nepal attempts to review the clinico-epidemiological profile of near-hanging patients. A retrospective review of case records was done for the near hanging patients admitted to a tertiary care teaching hospital in Nepal, between August 2012 and August 2014. Details regarding socio-demographic profile, circumstances of hanging, clinical details, and outcome etc. were obtained and examined. During the study period, 10 near hanging patients were admitted to the hospital. The majority of the patients were below 30 years. Mean age of the study group was 28.8 years. The GCS on arrival ranged between 5/15 and 15/15 with the mean GCS being 9.5/15. Hypoxic encephalopathy and cerebral edema were the only noted complications. None of the patient had a cervical spinal injury. All the patients survived the near hanging episode. The mean ICU and hospital stay were 3.9 days and 6.2 days respectively. Prompt resuscitation, active interventions and intensive care support favors a good prognosis. Psychiatric evaluation and support to the patients and their relatives is the key to preventing such attempts in future.

  20. Bilirubin-Induced Neurological Dysfunction: A Clinico-Radiological-Neurophysiological Correlation in 30 Consecutive Children.

    Science.gov (United States)

    van Toorn, Ronald; Brink, Philip; Smith, Johan; Ackermann, Christelle; Solomons, Regan

    2016-12-01

    The clinical expression of bilirubin-induced neurological dysfunction varies according to severity and location of the disease. Definitions have been proposed to describe different bilirubin-induced neurological dysfunction subtypes. Our objective was to describe the severity and clinico-radiological-neurophysiological correlation in 30 consecutive children with bilirubin-induced neurological dysfunction seen over a period of 5 years. Thirty children exposed to acute neonatal bilirubin encephalopathy were included in the study. The mean peak total serum bilirubin level was 625 μmol/L (range 480-900 μmol/L). Acoustic brainstem responses were abnormal in 73% (n = 22). Pallidal hyperintensity was observed on magnetic resonance imaging in 20 children. Peak total serum bilirubin levels correlated with motor severity (P = .03). Children with severe motor impairment were likely to manifest severe auditory neuropathy (P < .01). We found that in a resource-constrained setting, classical kernicterus was the most common bilirubin-induced neurological dysfunction subtype, and the majority of children had abnormal acoustic brainstem responses and magnetic resonance imaging. © The Author(s) 2016.

  1. Grey and White Matter Clinico-Anatomical Correlates of Disinhibition in Neurodegenerative Disease

    Science.gov (United States)

    Santillo, Alexander Frizell; Lundblad, Karl; Nilsson, Markus; Landqvist Waldö, Maria; van Westen, Danielle; Lätt, Jimmy; Blennow Nordström, Erik; Vestberg, Susanna; Lindberg, Olof; Nilsson, Christer

    2016-01-01

    Disinhibition is an important symptom in neurodegenerative diseases. However, the clinico-anatomical underpinnings remain controversial. We explored the anatomical correlates of disinhibition in neurodegenerative disease using the perspective of grey and white matter imaging. Disinhibition was assessed with a neuropsychological test and a caregiver information-based clinical rating scale in 21 patients with prefrontal syndromes due to behavioural variant frontotemporal dementia (n = 12) or progressive supranuclear palsy (n = 9), and healthy controls (n = 25). Cortical thickness was assessed using the Freesurfer software on 3T MRI data. The integrity of selected white matter tracts was determined by the fractional anisotropy (FA) from Diffusion Tensor Imaging. Disinhibition correlated with the cortical thickness of the right parahippocampal gyrus, right orbitofrontal cortex and right insula and the FA of the right uncinate fasciculus and right anterior cingulum. Notably, no relationship was seen with the thickness of ventromedial prefrontal cortex. Our results support an associative model of inhibitory control, distributed in a medial temporal lobe-insular-orbitofrontal network, connected by the intercommunicating white matter tracts. This reconciles some of the divergences among previous studies, but also questions the current conceptualisation of the “prefrontal” syndrome and the central role attributed to the ventromedial prefrontal cortex in inhibitory control. PMID:27723823

  2. Clinico-epidemiological study and quality of life assessment in melasma

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    Ravali Yalamanchili

    2015-01-01

    Aims: To study the clinico-epidemiological pattern, dermascopy, wood′s lamp findings and the quality of life in patients with melasma. Settings and Design: Observational/descriptive study. Materials and Methods: Patients with melasma were screened. History, clinical examination, Wood′s lamp examination (WLE and dermoscopy were done. Severity of melasma was assessed by the calculating melasma area severity index (MASI score. Quality of Life (QOL was assessed using MELASQOL scale with a standard structured questionnaire. Statistical Analysis: Descriptive, Chi-square test and contingency coefficient analysis. Results: In 140 cases of melasma, 95 (67.9% were females and 45 (32% were males. Common age group affected was 31-40 years (65%. Majority were unskilled workers with average sun exposure of more than 4 hours (44%. Family history was observed in 18% cases. Malar type (68% was the most common pattern observed. Mean MASI score was 5.7. WLE showed dermal type in 69% cases. Common findings on dermoscopy were reticular pigment network with perifollicular sparing and color varying from light to dark brown. Mean MELASQOL score was 28.28, with most patients reporting embarrassment and frustration. Conclusions: This study showed that melasma has a significant negative effect on QOL because though asymptomatic it is disfiguring affecting self-esteem. Dermoscopic examination did not help in differentiating the type of melasma.

  3. Advance of the National Program of Radiological Protection and Safety for medical diagnostic with X-rays; Avance del Programa Nacional de Proteccion y Seguridad Radiologica para diagnostico medico con rayos X

    Energy Technology Data Exchange (ETDEWEB)

    Verdejo S, M. [Direccion de Riesgos Radiologicos, Direccion General de Salud Ambiental (Mexico)

    1999-07-01

    The National Program of Radiological Protection and Safety for medical diagnostic with X-ray (Programa Nacional de Proteccion y Seguridad Radiologica para diagnostico medico con rayos X) was initiated in the General Direction of Environmental Health (Direccion General de Salud Ambiental) in 1995. Task coordinated with different dependences of the Public Sector in collaboration between the Secretary of Health (Secretaria de Salud), the National Commission of Nuclear Safety and Safeguards (Comision Nacional de Seguridad Nuclear y Salvaguardias) and, the National Institute of Nuclear Research (Instituto Nacional de Investigaciones Nucleares). The surveillance to the fulfilment of the standardization in matter of Radiological Protection and Safety in the medical diagnostic with X-rays has been obtained for an important advance in the Public sector and it has been arousing interest in the Private sector. (Author)

  4. Pulmonary sporotrichosis: case series and systematic analysis of literature on clinico-radiological patterns and management outcomes.

    Science.gov (United States)

    Aung, Ar Kar; Teh, Bing Mei; McGrath, Christopher; Thompson, Philip J

    2013-07-01

    Pulmonary infections by Sporothrix spp. manifest radiologically as cavitary or non-cavitary disease depending on whether the infection is primary pulmonary or multifocal sporotrichosis. Despite current guidelines, the optimal management for pulmonary sporotrichosis remains unclear. In order to clarify this, we present two cases of pulmonary sporotrichosis, as well as the results of a comprehensive literature review of treatment outcomes based on clinico-radiological presentation patterns of the disease. A literature search of all case reports in English language over the last 50 years (1960-2010) was conducted. Data on patient characteristics, risk factors, clinico-radiological patterns, treatment modalities and outcomes were collected and analyzed. A total of 86 cases were identified, i.e., 64 (74.4%) primary pulmonary and 22 (25.6%) multifocal sporotrichosis. Radiologically, primary pulmonary disease was commonly characterized by cavity formation which was lacking in multifocal infections (P = 0.0001). Immunosuppressant use was more common in multifocal sporotrichosis (P = 0.0001), while hemoptysis was more common in primary pulmonary form (P = 0.01). No other differences in patient characteristics or risk factors were noted. Extra-pulmonary multifocal sporotrichosis most commonly involved skin (81.8%) and joints (45.4%). For patients with cavitary primary pulmonary sporotrichosis, outcomes from medical therapy alone were inferior to surgical intervention (P = 0.02). However, for both primary pulmonary and multifocal sporotrichosis with non-cavitary disease, medical therapy alone provided good outcomes. Only 12 (16.7%) cases were treated with itraconazole. Treatment of pulmonary sporotrichosis should be guided by the clinico-radiological patterns of presentation. Medical therapy alone is likely sufficient for non-cavitary disease while early surgery should be considered for cavitary primary pulmonary sporotrichosis. The experience in treating cavitary disease

  5. Medication adherence among Nigerians with schizophrenia: correlation between clinico-demographic factors and quality of life

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    Oluseun P. Ogunnubi

    2017-03-01

    Full Text Available Medication adherence contributes significantly to symptom remission, recovery and wellbeing in mental illnesses. We evaluated how medication adherence correlates with clinico-demographic factors and quality of life (QoL in a sample of Nigerians with schizophrenia. This descriptive crosssectional study involved 160 randomly selected participants with confirmed diagnosis of schizophrenia based on MINI International Neuropsychiatric Interview. Data on socio-demographic and clinical characteristics of participants were collected with a questionnaire. Medication adherence was assessed with Morisky Medication Adherence Questionnaire, and participants completed the World Health Organization Quality of Life Scale-BREF. The mean age of participants was 38.54 (±11.30 years, and all the participants were on antipsychotics, but only 45% were adherent to their medication. Out of all the participants, 45 (28.2% considered their overall QoL to be good, 97 (60.6% considered theirs to be fair, while 18 (11.2% reported poor QoL. Medication non-adherence correlated negatively with good QoL across multiple dimensions including overall QoL (r=- 0.175, health satisfaction (r=-0.161, physical (r=-0.186 and psychological domain (r=-0.175. Again, participant’s age (r=- 0.190 and age of onset of illness (r=-0.172 correlated negatively with medication nonadherence, and a trend towards relapse delay with medication adherence was also observed (r=-0.155. The effect size of these correlations were however small. Our findings suggest a link between medication adherence and QoL in schizophrenia, such that strategy that addresses medication nonadherence and its determinants may have potential benefits on wellbeing. Further hypotheses-driven studies are desirable.

  6. Clinico-pathologic profile of women with palpable breast lumps in Chitwan Medical College, Nepal

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    Ranabhat S

    2015-07-01

    Full Text Available Background: Spectrum of female breast diseases is manifold and includes various non-neoplastic and neoplastic conditions. This study focused on the clinico-pathological profile of several breast diseases, including fibrocystic change, fibroadenoma and breast carcinoma. Methods: This cross sectional analytic observational study included Fine Needle Aspiration Cytology cases of female breast diseases diagnosed over three years from 2011 to 2014 in Chitwan Medical College Teaching hospital in Central Nepal. Univariate analysis was carried out to find out age group-wise proportion of the diseases in relation to five cytologic categories and various cytomorphologic diagnoses. Independent samples t-test was used to find out the significance of difference between mean age of benign and malignant breast diseases. Results: The proportion of benign, suspicious for malignancy and malignant breast diseases was 90.4 %, 0.8% and 8.8 % respectively. The mean age of patients at diagnosis for benign diseases and malignant disease was 31.7+/- 10.4 years and 49.2 +/- 12.0 years respectively. t-test showed difference in mean age between benign and malignant diseases to be statistically significant (t=8.79, p= <0.001. Fibrocystic change and fibroadenoma were the most common breast disease overall and the most common neoplasm respectively. 58.1 %, 25.9 % and 6.5 % of all carcinoma cases in this study were found below 50, below 40 and below 30 years of age respectively. Conclusions: Fibrocystic change and fibroadenoma are most common disease of breast and most common neoplasm of breast respectively. Breast cancer occurs in younger women in Nepal in comparison to women in developed countries. Therefore, breast cancer prevention programs in Nepal should target young women also. [Int J Res Med Sci 2015; 3(7.000: 1611-1616

  7. Pattern of glomerular diseases in Sudanese children:A clinico-pathological study

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    Abdelraheem Mohamed

    2010-01-01

    Full Text Available Glomerular diseases are a common cause of chronic kidney disease (CKD in many countries. The pattern of glomerular diseases has been reported in adult Sudanese patients but there has been no previous study on Sudanese children. The aim of this study is to describe the pattern of glomerular diseases in Sudanese children from a clinico-pathological perspective. We retrospectively reviewed the clinical records of 321 children seen with nephritis/nephrosis at the Pediatric Nephrology Unit, Soba University Hospital and Dr. Salma Dialysis and Kidney Transplantation Centre, Khartoum, Sudan during the period from 2002 to 2007. Biopsies were studied with light microscopy and immuno-histochemistry with electron microscopy performed abroad in selected patients (predominantly Alport′s. The mean age of the 321 study children was 8.71 years (range 2 months-16 yrs of whom, 188 were males (60.2%. The most common presentation was with the nephrotic syndrome, seen in 202 patients (62.9%. The most common glomerular disease encountered was minimal change disease, seen in 96 children (29.9%, followed by post-infectious GN in 78 (24.3% and focal and segmental glome-rulosclerosis, seen in 44 patients (13.7%. Membranoproliferative GN (MPGN was seen in 43 patients (13.4% while mesangioproliferative GN was seen in 24 (7.5%. Systemic lupus erythematosus (SLE was the most common secondary glomerular disease accounting for 16 patients (4.9%. HBsAg was positive in 10 patients and the most common associated lesion was MPGN (60%. Histopathology enabled us to change the therapy in 55.3% of the patients. Our study suggests that the pattern of GN in our cohort of patients is comparable with reports from other parts of the world with a high prevalence of post-infectious GN. Renal biopsies have an important part in planning therapy and management. Also, the importance of establishing a Sudanese renal registry including pediatric patients is stressed.

  8. Lichen simplex chronicus of anogenital region: A clinico-etiological study

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    R Rajalakshmi

    2011-01-01

    Full Text Available Background: Lichen simplex chronicus (LSC of the anogenital region, is a benign, extremely uncomfortable disease. Aims: As very little is known about the cause of anogenital LSC (AGLSC, we undertook this study to determine various clinico-etiological factors involved in it and to assess the frequency of AGLSC. Methods: This was a descriptive study, including 105 patients with AGLSC, who attended the Dermatology clinic in our institute from September 2007 to June 2009. Detailed history, physical examination, and relevant investigations were done. The collected data were tabulated and analyzed. Results: The frequency of AGLSC among patients presenting with anogenital pruritus was 2.54%. Primary AGLSC was more common than secondary AGLSC (69.5% vs. 30.5%. AGLSC manifested more commonly in males than in females (56.2% vs. 43.8%. The mean duration of the disease was 30.6 months. The common triggering factors for itching were sweating (41.9%, rubbing of thighs while walking for long distances (9.5%, and mental stress (5.7%. Pruritus of AGLSC was related to the intake of various food items in 37.1% of patients. In males, scrotum was the predominant site involved (89.8%, whereas in females, labia majora was the predominant site involved (78.2%. Nearly one-third of cases (30.5% of AGLSC had some other dermatoses in the anogenital region. Conclusions: Though psychological factors are thought to play an important role in disease causation and perpetuation among AGLSC patients, their significance could not be ascertained by us.

  9. Clinico-pathological nomogram for predicting BRAF mutational status of metastatic colorectal cancer

    Science.gov (United States)

    Loupakis, Fotios; Moretto, Roberto; Aprile, Giuseppe; Muntoni, Marta; Cremolini, Chiara; Iacono, Donatella; Casagrande, Mariaelena; Ferrari, Laura; Salvatore, Lisa; Schirripa, Marta; Rossini, Daniele; De Maglio, Giovanna; Fasola, Gianpiero; Calvetti, Lorenzo; Pilotto, Sara; Carbognin, Luisa; Fontanini, Gabriella; Tortora, Giampaolo; Falcone, Alfredo; Sperduti, Isabella; Bria, Emilio

    2016-01-01

    Background: In metastatic colorectal cancer (mCRC), BRAFV600E mutation has been variously associated to specific clinico-pathological features. Methods: Two large retrospective series of mCRC patients from two Italian Institutions were used as training-set (TS) and validation-set (VS) for developing a nomogram predictive of BRAFV600E status. The model was internally and externally validated. Results: In the TS, data from 596 mCRC patients were gathered (RAS wild-type (wt) 281 (47.1%); BRAFV600E mutated 54 (9.1%)); RAS and BRAFV600E mutations were mutually exclusive. In the RAS-wt population, right-sided primary (odds ratio (OR): 7.80, 95% confidence interval (CI) 3.05–19.92), female gender (OR: 2.90, 95% CI 1.14–7.37) and mucinous histology (OR: 4.95, 95% CI 1.90–12.90) were independent predictors of BRAFV600E mutation, with high replication at internal validation (100%, 93% and 98%, respectively). A predictive nomogram was calculated: patients with the highest score (right-sided primary, female and mucinous) had a 81% chance to bear a BRAFV600E-mutant tumour; accuracy measures: AUC=0.812, SE:0.034, sensitivity:81.2% specificity:72.1%. In the VS (508 pts, RAS wt: 262 (51.6%), BRAFV600E mutated: 49 (9.6%)), right-sided primary, female gender and mucinous histology were confirmed as independent predictors of BRAFV600E mutation with high accuracy. Conclusions: Three simple and easy-to-collect characteristics define a useful nomogram for predicting BRAF status in mCRC with high specificity and sensitivity. PMID:26575603

  10. Hemato-biochemical and clinico-epidemiological aspects of parturient hemoglobinuria in Nili-Ravi buffaloes

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    A. Khan

    2010-02-01

    Full Text Available For this study, 60 buffaloes suffering from parturient hemoglobinuria (PHU were randomly selected from field cases occurring in three districts of Punjab, Pakistan and simultaneously, 60 clinically healthy buffaloes of similar description from the same localities were included for case control study. Clinico-epidemiological data were collected. Blood/serum samples from all buffaloes were collected and analyzed. The most prominent clinical sign was passing of red to coffee colored urine. Milk production was reduced and respiration and pulse rates were significantly accelerated. Ruminal motility was significantly weak and reduced along with characteristic straining while defecating. The case fatality was 15%. A significantly high occurrence of PHU was observed in the winter season (41.8%. Maximum number of affected buffaloes (25.0% was in 4th lactation. Twenty-seven (45.0% buffaloes developed hemoglobinuria in the post calving period and majority (59.3% of these were within 1-23 days of calving. Of the 33 (55.0% PHU affected pregnant buffaloes, 18 (54.6% were in their third trimester. The highest cases of PHU were observed in buffaloes producing 10 or more liters of milk/day (42.5%. Recurrence of PHU was observed in 18.3% buffaloes. Mean values of total erythrocyte counts, hemoglobin concentration and packed cell volume were lower (P<0.001, while erythrocyte sediment rate was higher (P<0.001 in PHU affected buffaloes as compared to the values in healthy buffaloes. Neutrophils were significantly higher, while lymphocytes and erythrocytic glucose-6-phosphate dehydrogenase (G6PD were lower, in PHU affected buffaloes than in healthy buffaloes. Serum phosphorus, copper and selenium were significantly (P<0.001 lower, whereas potassium, iron and molybdenum (P<0.001 were higher in buffaloes suffering from PHU than healthy buffaloes.

  11. Clinico-serologic co-relation in bi-directional ABO incompatible hemopoietic stem cell transplantation

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    Sabita Basu

    2015-01-01

    Full Text Available Background: The ABO blood group system is of prime significance in red cell transfusion and organ transplantation. However, ABO compatibility is not critical in allogenic hemopoietic stem cell transplantation (HSCT and approximately 40-50% of hemopoietic stem cell transplants are ABO incompatible. This incompatibility may be major, minor or bi-directional. Though there are descriptions of transfusion practice and protocols in ABO incompatible HSCT, there are considerable variations and transfusion support in these patients can be very challenging. Aims: The immunohematologic observations in two cases of bi-directional ABO incompatible HSCT have been described, and clinico-serologic correlation has been attempted. Materials and Methods: In both cases, peripheral blood stem cell harvests were obtained using the Cobe spectra cell separator. Immunohematologic assessments in the donor and recipient were done as a part of pre HSCT evaluation. Both the standard tube technique and column agglutination method (Ortho Biovue Micro Bead System was used. Antibody screen was done by column agglutination method using three cell panel (Surgiscreen cells. Isoagglutinin titration was done by the master dilution method and standard validated techniques were used. Results: The pattern of laboratory findings in the two cases was different and so were the clinical outcomes. Although there was early engraftment in the first case, the second case developed pure red cell aplasia and this was well-reflected in the immunohematologic assessments. Conclusion: Immunohematologic assessment correlated well with the clinical picture and could be used to predict clinical outcome and onset of complications in ABO incompatible HSCT.

  12. Clinico-Epidemiological study of poisoning in a tertiary care hospital in Bangladesh

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    Rabiul Hossain

    2017-01-01

    Full Text Available Objective: The scale of the problem of poisoning is enormous hence clinico epidemiological spectrum of all poisoning cases need to explore to generate the management tool. Methods: This prospective study was done at two medicine units (Unit 5 and 10 of Dhaka Medical College Hospital from July to December 2010 where all poisoning cases were seen. A total of 2890 patients were admitted out of which 600 were taken into the study. Results: Among the poisoning cases 29% were pesticide, 27% travel related poisoning, and 20% benzodiazepine. 70% of poisoning occurred below 30 years of age and male: female ratio was 3:2. Incidence of poisoning was highest among students (31% and housewives (25%. Majority of the patients were from urban area (76% and most common intention was suicidal (66%. Familial disharmony was the prime cause (63% behind poisoning. 42% cases got admitted between 5-8 hours of poisoning and more than 80% patients were admitted in the hospital directly without getting any first aid anywhere. Sixty-eight percent had Glasgow coma scale (GCS score above 10 during admission. Cardinal clinical features of poisoning were nausea/vomiting (63%, drowsiness (56%, miosis (31%. Seventy percent patients were treated with only general and supportive treatment and specific antidotes were used in 30% cases. Case fatality for pesticide, benzodiazepine/anti-psychotic, rodenticide and snake bite was 6.9%, 2.2%, 8.3% and 3.3% respectively. Conclusion: To assess the magnitude of problem, awareness of the public for prevention, immediate first aid measures and quick hospital admission is crucial component of poisoning.

  13. Clinico-biologic profile of Langerhans cell histiocytosis: A single institutional study

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    Narula G

    2007-01-01

    Full Text Available Context: Langerhans cell histiocytosis (LCH is a rare atypical cellular disorder characterized by clonal proliferation of Langerhans cells leading to myriad clinical presentations and highly variable outcomes. There is a paucity of Indian studies on this subject. Aim: To present the experience of management of LCH at a single institution. Settings and Design: This is a retrospective observational study of patients with LCH who presented at the Tata Memorial Hospital between January 1987 and December 2002. Materials and Methods: Fifty-two patients with LCH were treated in the study period. Due to the long observation period and variability in diagnostic and therapeutic protocols, the patients were risk-stratified based on present criteria. The disease pattern, management approaches and treatment outcomes of patients were recorded. Statistical Analysis Used: Statistical analyses were done using Student′s ′t′ test, test for proportion and survival estimates based on the Kaplan-Meier method. Results: The median age at presentation was 3 years and more than 48% of the patients had Group I disease. Skeleton, skin and lymphoreticular system were the commonly involved organs. Majority (80% required some form of therapy. The projected overall survival is 63% at 10 years and mean survival is 118 months. Seventeen percent of surviving patients developed long-term sequelae. Conclusions: The clinico-biologic profile of LCH patients in India is largely similar to international patterns except a higher incidence of lymphoreticular involvement. Majority of the patients respond favorably to therapy and have a good outcome, except a subset of Group I patients who warrant enrolment in clinical trials with innovative therapeutic strategies to improve outcome.

  14. A CLINICO - MICROBIOLOGICAL STUDY OF PYODERMA WITH SPECIAL REFERENCE TO MRSA

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    Animesh

    2015-04-01

    Full Text Available BACKGROUND AND OBJECTIVES: Pyoderma refers to pyogenic infection of the skin. Staphylococcus aureus is one of the most common pathogen in pyoderma and due to indiscriminate use of antibiotics it has lead to development of resistant strains known to be sensitive before. AIMS: A clinico - microbiological study of pyoderma with special reference to MRSA. SETTINGS AND DESIGN: STUDY DESIGN: Cross - sectional study . STUDY SETTING: O.P.D of Dermatology Department. STUDY SUBJECTS : Patients of all age groups,both gender, attending De rmatology out patient department were incorporated. STUDY SAMPLE: 200 patients with Pyoderma attending the O.P.D in 1 year. STUDY PERIOD: 6 Months . METHODS: In this cross sectional study, 200 patients of either sex and all age groups diagnosed as pyoderma and having frank pustular lesion were included after detailed history and examination. A sample of pus was collected taking aseptic precautions with the help of sterile swabs and investigated for antibiotic sensitivity pattern of isolated organism. RESULT S: Out of 200 patients of indoor and outpatient department Single isolates were yielded in 166 patients and multiple organisms were isolated in 7 patients and there was no growth in 27 patients. Coagulase positive Staphylococcus was the commonest isolate i .e. 142 organisms, among which MRSA was 41 (23%. Highest susceptibility was seen to Chloramphenicol 100%, Teicoplatin 100%, Vancomycin 99% Amikacin 90%, Linezolid 82%, Clindamycin 76%, Gentamicin 67% . Most Resistant drugs were Cefoperazone 100%, Cefotaxime 100% , Cephazolin 100%, Penicillin - G 100 %, Cefipime 90%,Cefipime 90%, erythromycin 77% ciprofloxacin 75%, Cotrimoxazole 63% & cefoxitin showed 52% resistance. CONCLUSION: Though Pyodermas are common skin problem often because of therapeutic failure and due to resistance of organism and emergence of MRSA stains to antibiotics it becomes difficult to treat. Hence, the study of culture and sensitivity can be highly

  15. Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps.

    Science.gov (United States)

    Albuquerque, Andreia; Rios, Elisabete; Carneiro, Fátima; Macedo, Guilherme

    2014-12-01

    Inflammatory fibroid polyps are rare mesenchymal lesions. The frequency of Helicobacter pylori infection in the gastric mucosa overlying inflammatory fibroid polyps and its relation with the histologic features of the polyps are undetermined. The clinico-pathological features of inflammatory fibroid polyps, the frequency of Helicobacter pylori infection in the overlying gastric mucosa, and its putative impact on the phenotype of the polyps were evaluated. Gastric inflammatory fibroid polyps diagnosed in our Hospital from 1998 to 2012 were reviewed and the histological. The histological sections were stained with hematoxylin and eosin and modified Giemsa for the evaluation of Helicobacter pylori infection. Inconclusive cases were further analyzed by immunohistochemistry with anti-Helicobacter pylori antibody. Diagnosis was confirmed in 54 polyps, 85 % developed in females, mean age 63 ± 11 years. Most polyps were sessile (74 %), with a mean size of 15 ± 12 mm, 96 % were located in the antrum and 85 % were removed by snare polypectomy. Helicobacter pylori infection was identified in 48 % of the polyps. Most inflammatory fibroid polyps developed in the submucosa, and mucosal extension was observed in 96 % of the cases. Chronic gastritis was observed in all cases (63 % with activity, 31 % with intestinal metaplasia, and 61 % with foveolar hyperplasia). Erosion and ulceration of the overlying gastric mucosa was observed in 48 % and 11 % of the polyps, respectively. Onion skin features were present in 52 % of the polyps and were more frequently observed in cases without evidence of Helicobacter pylori infection. Background changes in gastric mucosa were not distinctive according to Helicobacter pylori infection. Chronic atrophic gastritis with intestinal metaplasia was associated with the presence of perivascular onion skin lesions. To our knowledge, this is the second largest series of gastric inflammatory fibroid polyps. Helicobacter pylori infection was

  16. Expression of Hpa and CD222 in bladder carcinoma and analysis of clinico-pathologic correlation

    Institute of Scientific and Technical Information of China (English)

    Shuhong Shi; Hui Zhang

    2014-01-01

    Objective:Our study aimed to investigate the relationships between the clinico-pathologic features and the hepa-ranase (Hpa) and CD222 expressions in bladder carcinoma. Methods:The expressions of Hpa and CD222 in 95 bladder carcinoma specimens and 20 paraneoplastic bladder tissues (controls) were assessed using the immunohistochemical stain-ing method. Results:The positive expression rates of Hpa and CD222 in bladder carcinoma were 68.42%and 61.05%, respectively. The positive rate of Hpa was significantly higher in the carcinoma specimens than in the control specimens (P<0.01). Similarly, the Hpa expression in the invasive bladder carcinoma was significantly higher than that in the non-invasive bladder carcinoma (P<0.01). A positive correlation was observed between the expressions of Hpa and CD222 (P<0.05). The expressions of Hpa and CD222 were significantly correlated with lymphatic invasion and TNM staging (P<0.05). The 5-year survival rate was significantly higher in negative expression of the Hpa group than that in the positive expression group (P<0.05). Compared with the non-co-positive expression group, the 5-year survival rate in the co-positive expression of Hpa and CD222 group was significantly lower (P<0.05). Conclusion:High Hpa and CD222 expressions in tumor tissues were associated with the occurrence and development of bladder carcinoma. Our results provide helpful information for the further diagnosis and therapy of bladder carcinoma.

  17. Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features

    Institute of Scientific and Technical Information of China (English)

    Martin Anlauf; Wolfram T Knoefel; Henning Dralle; Paul Komminoth; Philipp U Heitz; Aurel Perren; Günter Kl(o)ppel; Nele Garbrecht; Tobias Henopp; Anja Schmitt; Regina Schlenger; Andreas Raffel; Markus Krausch; Oliver Gimm; Claus F Eisenberger

    2006-01-01

    Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal reflux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished from tumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1-associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1-associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1-associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as

  18. CLINICO-ECONOMICAL ANALYSIS OF THE TREATMENT EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREES

    Directory of Open Access Journals (Sweden)

    L. A. Haisheva

    2016-01-01

    Full Text Available Aim. Clinico-economical analysis of arterial hypertension (HT treatmentMaterial and methods. 78 patients with HT were involved into the study. Patients were spitted into two groups depending on HT degree. The first group – 38 patients with HT 1 degree. The second one – 40 patients with HT 2 degree. Patients of group 1 had initial antihypertensive therapy with angiotensinconverting enzyme inhibitors. If target level of blood pressure (BP had not been reached, therapy was changed on fixed combination of lisinopril and hydrochlorothiazide. Patients of group 2 had initial combined antihypertensive therapy with lisinopril and hydrochlorothiazide. If it was needed amlodipine maleat was added. Clinico-economical analysis was performed according to “cost-efficacy” approach at the end of 3 month therapy.Results. About 50% of hypertensive patients do not follow physician recommendations in out-patient practice. They decrease a dose of medicine or stop therapy themselves. More than 6% of them perform self-treatment.Conclusion. Analysis showed that therapy of patients with HT of 1 degree is economically more profitable regarding target BP achievement. It is more reasonable to start antihypertensive therapy with fixed low dose combination and add calcium antagonists if it is needed in patients with HT of 2 degree.

  19. CLINICO-ECONOMICAL ANALYSIS OF THE TREATMENT EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREES

    Directory of Open Access Journals (Sweden)

    L. A. Haisheva

    2009-01-01

    Full Text Available Aim. Clinico-economical analysis of arterial hypertension (HT treatmentMaterial and methods. 78 patients with HT were involved into the study. Patients were spitted into two groups depending on HT degree. The first group – 38 patients with HT 1 degree. The second one – 40 patients with HT 2 degree. Patients of group 1 had initial antihypertensive therapy with angiotensinconverting enzyme inhibitors. If target level of blood pressure (BP had not been reached, therapy was changed on fixed combination of lisinopril and hydrochlorothiazide. Patients of group 2 had initial combined antihypertensive therapy with lisinopril and hydrochlorothiazide. If it was needed amlodipine maleat was added. Clinico-economical analysis was performed according to “cost-efficacy” approach at the end of 3 month therapy.Results. About 50% of hypertensive patients do not follow physician recommendations in out-patient practice. They decrease a dose of medicine or stop therapy themselves. More than 6% of them perform self-treatment.Conclusion. Analysis showed that therapy of patients with HT of 1 degree is economically more profitable regarding target BP achievement. It is more reasonable to start antihypertensive therapy with fixed low dose combination and add calcium antagonists if it is needed in patients with HT of 2 degree.

  20. Clinico-pathological features of patients with melanoma and positive sentinel lymph node biopsy: a single institution experience.

    Science.gov (United States)

    Homolak, Damir; Šitum, Mirna; Čupić, Hrvoje

    2015-01-01

    Sentinel lymph node biopsy (SLNB) is an established method for the assessment of tumor aggressiveness in patients with primary cutaneous melanoma (PCM). To improve the criteria for the selection of SLNB candidates, the aim of our study was to determine clinico-pathohistological parameters that can serve as predictors of metastatic progression. We retrospectively evaluated all available clinico-pathohistological parameters in 844 patients with PCM diagnosed between January 1, 2005 and December 31, 2010. SLNB was conducted in 484 (57.3%) patients, 122 (14.5%) of whom had a positive node. The association between predictors and SLNB outcomes (positive SLNB and metastatic development) was tested using logistic regression analysis. The main predictors of positive SLNB were Breslow thickness (adjusted odds ratio (AOR)=1.22; 95% confidence interval (CI)=1.11-1.33), Clark levels (AOR=1.78; 95% CI=1.31-2.40), ulceration (AOR=3.1; 95% CI=1.65-5.81), microsatellitosis, gender, and tumor localization. The predictors of metastatic spread were Breslow thickness (AOR=1,69; 95% CI=1.51-1.89), Clark level (AOR=3.59; 95% CI=2.79-4.62), nodular type of melanoma (AOR=8.21; 95% CI=1.70-39.53), ulceration, mitotic rate, microsatellitosis, gender, and tumor localization. It seems that these parameters should be taken into consideration when selecting patients for SLNB since tumor thickness is not a sufficient predictor of SLNB outcome, particularly in case of very thin lesions.

  1. Motor neuron diseases in the university hospital of Fortaleza (Northeastern Brazil): a clinico-demographic analysis of 87 cases.

    Science.gov (United States)

    Castro-Costa, C M; Oriá, R B; Vale, O C; Arruda, J A; Horta, W G; D'Almeida, J A; Santos, T J; Ramos, R S; Gifoni, M A

    2000-12-01

    In this retrospective (1980-1998) study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil), a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs). Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS) diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA), 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP), 2 as progressive muscular atrophy (PMA) and 1 as monomelic amyotrophy (MA), and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17), 30 to 39 years (n= 18), 40 to 69 years (n= 39) and 70 to 78 years (n= 4). From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS.

  2. Verrucous lesions of the oral cavity treated with surgery: Analysis of clinico-pathologic features and outcome.

    Science.gov (United States)

    Sadasivan, Anjana; Thankappan, Krishnakumar; Rajapurkar, Mayuri; Shetty, Sharankumar; Sreehari, Sreekala; Iyer, Subramania

    2012-01-01

    Verrucous lesions of the oral cavity can be of varied histopathology. The present study evaluates the clinico-pathological features of verrucous lesions of the oral cavity and analyzes the treatment outcomes. This is a retrospective study of 15 consecutive patients who presented with verrucous lesions of the oral cavity, during the 5-year period from January 2006 to December 2010. Demographic, clinico-pathological features, treatment details, and outcomes were analyzed. Fifteen patients with verrucous lesions of the oral cavity were treated with surgery as the primary modality. The mean age was 62.8 years (range 35-85 years). Wide excision of the primary lesion with adequate mucosal and soft-tissue margins was carried out. Free-flap reconstruction was done in eight patients. All patients remain loco-regionally controlled with good functional speech and swallowing outcome. Verrucous lesions of the oral cavity are a distinct clinical entity with varied histopathology. A surgical excision with wide margins and appropriate reconstruction is necessary to optimize the disease and functional outcome.

  3. CLINICO - HAEMATOLOGICAL PROFILE AND OUTCOME OF CEREBRAL MALARIA IN A TEACHING HOSPITAL OF SOUTH EAST RAJASTHAN

    Directory of Open Access Journals (Sweden)

    Gautam Lal

    2015-05-01

    Full Text Available AIM: Evaluation of Clinico - hematological profile and outcome of cerebral malaria in semi urban hospital situated in endemic area. MATERIAL AND METHODS : A cross - sectional hospital - based study was conducted from August to November, 2014 at Department of Paediatrics SRG Zanana Hospital, Jhalawar Rajasthan. Every child, except who was previously abnormal neurologically, of the age of six month to 12 years, presented with a history of fever in the last 7 days, with o r without convulsion, and/or impaired consciousness, screened for malaria by peripheral blood smear examination and rapid diagnostic test for malaria parasite. On the basis of this screening examination, these children were classified definite cerebral mal aria where the peripheral smear was positive and probable cerebral malaria where the peripheral smear was negative. If the patients presented with fever, convulsion, and/or impaired level of consciousness, they were treated with Artesunate intravenously em pirically. Patients were followed - up regularly till they regained consciousness and when, they were able to swallow, treated with oral Artisunate and single dose of Sulphadoxine and Pyrimethamine combination is also given. RESULTS: Of the3332 admissions, 8 69 (26.08% were admitted for fever. Out of these 869 febrile patients 352 patients were having other obvious clinical diagnosis for fever. In remaining 517(59.49% cases were suspected to be suffering from malaria, but all of these children who were admit ted with the diagnosis of fever, were screened for malaria and 74(08.51%were found to be positive for malaria parasite either by peripheral blood smear or rapid diagnostic test or both. Cerebral malaria developed in 37 patients. Most cases were of age gro up of 2 - 5 years, 14children had definite cerebral malaria and 9 were labelled as suspected to have probable cerebral malaria. Neurological symptoms of altered sensorium, convulsion and abnormal behaviour ranged from 35

  4. CLINICO-EPIDEMIOLOGICAL PROFILE OF ORAL CANCER: A HOSPITAL BASED STUDY

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    Kapil H Agrawal

    2012-07-01

    Full Text Available Background: India is heading towards various types of non-communicable diseases, which are also known as modern epidemics. Among these modern epidemics cancer is among the ten commonest cause of mortality in developing countries including India. Oral cancer is a major problem in India and accounts for 50-70% of all the cancers diagnosed. Ninety percent (90% of oral cancers in South East Asia including India are linked to tobacco chewing and tobacco smoking. Research question: What is the profile of Oral cancer (Oral cavity cases reported in the hospital? Objective: To study the clinico-epidemiological profile associated with Oral cancer cases. Methods: Study Design: Hospital based, Cross -sectional study. Settings: Shri Siddhivinayak Ganapati Cancer Hospital, Miraj, Maharashtra. Participants and Sample size: As it is a time bound study sample size comprised of all the confirmed cases of oral cancer reported in the hospital during the study period. The study was carried out from 1st March 2005 to 28th February 2006. Study variables included demographic factors, socioeconomic factors, enquiries regarding modifiable risk factors such as tobacco usage, alcohol consumption, site involved (within oral cavity, staging, histopathological examination, treatment modality used. Data entry and statistical analysis was done using Microsoft excel. Data presented in form of percentages and proportions. Results: Out of the total 160 cases, majority of the subjects were above 40 years age. 36 (22% of subjects were young adults (below 40 years age. 125 (78% subjects were male. Most of the subjects belonged to upper lower and lower middle socio-economic scale according to modified Kuppuswamy classification. It was observed that 139 (87% cases consumed tobacco in all forms. Out of these, ninety cases consumed tobacco in chewable form. Tobacco was chewed mainly in the form of gutka. Only ten (10 female subjects chewed tobacco. No female subjects smoked. The most

  5. Clinico-pathological profile in the infants and children in dengue 2012 epidemic, Kolkata

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    Saha K Ashis, Ghosh Shibendu

    2014-03-01

    Full Text Available Background: Dengue fever (DF is responsible for cyclical and frequent epidemic in different parts of India in its varieties of presentations. In 1992 large number of children died of Dengue hemorrhagic fever (DHF. Aims and objective: In this study, we evaluated the demography and clinico-pathological profile in dengue affected infants and children in 2012 Kolkata epidemic. Materials and methods: Total 233 patients (between 1-18 years, with either Non structural protein 1 antigen or dengue Immunoglobulin positive admitted in our hospital. After taking proper history and physical examination, blood were sent for different hematological and biochemical examinations on the day of admission and after 24-48 hours of admission. We differentiated the dengue patients into DF and DHF based on platelet count. Results: Male female ratio and DF to DHF ratio were 1: 0.86 and 1: 3.5 respectively. Mean age of DF and DHF were 10.31±5.41 years and 12.6±4.51 years respectively. Mean duration of fever in DF and DHF cases were 5.33±1.13 and 6.08±1.79 days respectively. Headache, backache, nausea/vomiting, rash, anorexia, loose motions were statistically significant in DF. In spite of significant positive tourniquet test in DHF patients (76.92%, only 13 patients showed evidence of bleeding. Hematocrit (Hct values between 30-40 and below 30 were significant in DHF and DF patients respectively. Leucopenia and increased liver enzymes (SGOT and SGPT were commonly observed in both DF and DHF patients. Hepatomegaly was observed in 13.72% of DF patients, whereas, isolated hepatomegaly, ascites, combined hepatomegaly with ascites and evidence of pleural effusion were observed in 4.94%, 1.64%, 3.29% and 7.14% of DHF patients respectively. Conclusion: In seropositive DHF patients, fever, headache, backache, loose motions were the predominant symptoms associated with hepatomegaly, elevated liver enzymes and evidence of plasma leakage.

  6. Efecto del consumo de linaza en el perfil lipidico, el control del cancer y como terapia de reemplazo hormonal en la menopausia: una revision sistematica de ensayos clinicos aleatorizados

    National Research Council Canada - National Science Library

    Molina Castano, Carlos Federico; Ruiz Pineda, Adriana Marcela; Lopez Marin, Beatriz Estella; Arango Alzate, Catalina Maria; Gaviria Gomez, Berta Lucia

    2011-01-01

    ... andropausia. Materiales y metodos: se realizo una revision sistematica de ensayos clinicos aleatorizados que examinaron los efectos del consumo de linaza sobre el peso corporal, la concentracion de lipidos sanguineos, el control...

  7. [From classification medicine to clinical medicine (the end of the XVIII century--1870s). Communication 2. The first stage of clinical medicine development: introduction of the method of clinico-anatomic correlations].

    Science.gov (United States)

    2011-01-01

    The first stage of clinical medicine development is analysed which covers the period from early 1800s to middle 1870s. Considered are basic research achievements associated with introduction of the method of clinico-anatomic correlations into practical medicine.

  8. Para-clinico-pathological observations of insidious incidence of canine hepatozoonosis from a mongrel dog: a case report.

    Science.gov (United States)

    Kaur, Paramjit; Deshmukh, S; Singh, Rajsukhbir; Bansal, B K; Randhawa, C S; Singla, L D

    2012-04-01

    A rare case of canine hepatozoonosis in a mongrel dog with para-clinico-pathological observations has been reported. The study included detailed haemato-biochemical changes at two stages, i.e. before treatment and after treatment with adopted therapy. Before therapy, blood picture revealed normocytic hypochromic anaemia and neutrophilic leucocytosis with variable counts of platelets. Thirty-seven percent of neutrophils were found infected with gametocytes of Hepatozoon canis. Following treatment, further decrease in haemoglobin value with a relative increase in lymphocyte count was seen. Biochemically, increase in alkaline phosphatase, blood urea nitrogen and creatinine levels along with hyperproteinemia was seen. The 14 days chemotherapy did not bring a respite for the dog and the level of parasitaemia was 33% after the treatment. The alkaline phosphatase and creatinine level further rose up following therapy with sulphadiazine and clindamycin. Continual study is required to explain the best possible therapeutic combination to deal H. canis.

  9. Primary high grade sarcoma of the specialised prostatic stroma: a case report with clinico-pathological considerations.

    Science.gov (United States)

    Fraggetta, F; Pepe, P; Giunta, M L; Aragona, F

    2008-12-01

    Malignant tumours of the prostate other than carcinomas are rare. One such malignant tumours arising from the specialised stromal tissue of the prostate is stromal prostatic sarcoma (namely low-grade and high-grade). Herein, we report the clinico-pathological features of a high grade stromal sarcoma of the prostate occurring in a 65-year-old man who presented for urinary obstructive symptoms. The clinical picture suggested a benign prostatic hyperplasia, and surgery consisting in a transcapsular adenomectomy was performed. Following a pathological diagnosis of high grade prostatic stromal sarcoma, a radical cystoprostatectomy and bilateral pelvic node dissection was performed showing residual high grade stromal sarcoma of the prostate and incidental in situ urothelial carcinoma of the bladder. No further medical treatments were planned. One year after surgery the patient is well with no evidence of local disease or distant metastases.

  10. Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model.

    Science.gov (United States)

    Baumann, Tycho; Delgado, Julio; Santacruz, Rodrigo; Martínez-Trillos, Alejandra; Royo, Cristina; Navarro, Alba; Pinyol, Magda; Rozman, María; Pereira, Arturo; Villamor, Neus; Aymerich, Marta; López, Cristina; Carrió, Anna; Montserrat, Emili

    2014-10-01

    We investigated the clinico-biological features, outcomes, and prognosis of 949 patients with chronic lymphocytic leukemia according to age. No biological differences (cytogenetics by fluorescent in situ hybridization, IGHV, ZAP-70, CD38, NOTCH1, SF3B1) were found across age groups. Elderly patients (>70 years; n=367) presented more frequently with advanced disease (Binet C/Rai III-IV: 10/12% versus 5/5%; P4; hazard ratio 2.2, P<0.001) and response (treatment failure versus response: hazard ratio 1.60, P<0.04) were the most important prognostic factors for overall survival. In conclusion, in our series, elderly patients with chronic lymphocytic leukemia did not present with any biological features distinct from those of younger patients, but did have a poorer clinical outcome. This study highlights the importance of comprehensive medical care, achieving response to therapy, and specific management strategies for elderly patients with chronic lymphocytic leukemia.

  11. RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features.

    Science.gov (United States)

    Gaidzik, V I; Teleanu, V; Papaemmanuil, E; Weber, D; Paschka, P; Hahn, J; Wallrabenstein, T; Kolbinger, B; Köhne, C H; Horst, H A; Brossart, P; Held, G; Kündgen, A; Ringhoffer, M; Götze, K; Rummel, M; Gerstung, M; Campbell, P; Kraus, J M; Kestler, H A; Thol, F; Heuser, M; Schlegelberger, B; Ganser, A; Bullinger, L; Schlenk, R F; Döhner, K; Döhner, H

    2016-11-01

    We evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid leukemia (AML). RUNX1 mutations were found in 245 of 2439 (10%) patients; were almost mutually exclusive of AML with recurrent genetic abnormalities; and they co-occurred with a complex pattern of gene mutations, frequently involving mutations in epigenetic modifiers (ASXL1, IDH2, KMT2A, EZH2), components of the spliceosome complex (SRSF2, SF3B1) and STAG2, PHF6, BCOR. RUNX1 mutations were associated with older age (16-59 years: 8.5%; ⩾60 years: 15.1%), male gender, more immature morphology and secondary AML evolving from myelodysplastic syndrome. In univariable analyses, RUNX1 mutations were associated with inferior event-free (EFS, P<0.0001), relapse-free (RFS, P=0.0007) and overall survival (OS, P<0.0001) in all patients, remaining significant when age was considered. In multivariable analysis, RUNX1 mutations predicted for inferior EFS (P=0.01). The effect of co-mutation varied by partner gene, where patients with the secondary genotypes RUNX1(mut)/ASXL1(mut) (OS, P=0.004), RUNX1(mut)/SRSF2(mut) (OS, P=0.007) and RUNX1(mut)/PHF6(mut) (OS, P=0.03) did significantly worse, whereas patients with the genotype RUNX1(mut)/IDH2(mut) (OS, P=0.04) had a better outcome. In conclusion, RUNX1-mutated AML is associated with a complex mutation cluster and is correlated with distinct clinico-pathologic features and inferior prognosis.

  12. Triggers, risk factors and clinico-pathological features of urticaria in dogs - a prospective observational study of 24 cases.

    Science.gov (United States)

    Rostaher, Ana; Hofer-Inteeworn, Natalie; Kümmerle-Fraune, Claudia; Fischer, Nina Maria; Favrot, Claude

    2017-02-01

    Urticaria and anaphylaxis are frequently encountered in veterinary practice, but little is known about the causes and relative frequencies of these reactions. This study was designed to improve current knowledge on the triggers, risk factors and clinico-pathological features of urticaria. Twenty four dogs with signs of urticaria with or without anaphylaxis. The study included dogs with cutaneous immediate-type hypersensitivity reactions. The cases were grouped by clinical severity into either an urticaria or an anaphylaxis group. All treatments and diagnostic tests (haematology, biochemical profile, allergy investigation) were recorded. A causality algorithm for urticaria and anaphylaxis (ALUA) was designed to determine the probability of the identified triggers and cofactors. Disease incidence, breed, age and gender predispositions were evaluated statistically. Sixteen of 24 urticaria cases were associated with anaphylaxis whilst 8 of 24 were confined to the skin. The annual hospital incidence was 0.12%. Females seemed to be over-represented (2.4:1) and most of the dog breeds were pure breed (22 of 24), with Rhodesian ridgeback, boxer, beagle, Jack Russell terrier, French bulldog and Vizslas over-represented. In addition to skin lesions, the most frequently and severely affected organ systems were the gastrointestinal and cardiovascular systems. The predominant blood abnormalities were elevated lipase and alanine aminotransferase values. Insects, food and drugs were the most commonly identified triggers. To the best of our knowledge, this is the first study describing the trigger factors and clinico-pathological features of dogs with urticaria in veterinary medicine. Insects, food and drugs were the most frequently detected triggers. © 2016 ESVD and ACVD.

  13. Spinal dural arterio-venous fistula: Clinico-radiological profile and outcome following surgical occlusion in an Indian neurosurgical center

    Directory of Open Access Journals (Sweden)

    Sivashanmugam Dhandapani

    2013-01-01

    Full Text Available Background: Spinal dural arteriovenous fistula (SDAVF is a common type of spinal vascular lesion. However, there has not been any published study on its clinico-radiological characteristics or surgical outcome from India. Aim: The aim of this study was to determine the clinico-radiological features of patients with SDAVF, outcomes following surgical ligation of the fistula and the various factors involved. Materials and Methods: Patients who were operated for SDAVF were studied for demographic details, symptoms, clinical severity, radiological features and neurological outcome in the form of improvement in gait disability grades. Appropriate statistical tests were performed. Results: There were 22 (19 males, 3 females patients of SDAVF who underwent surgical ligation with a mean age of 55 years. The mean duration of symptoms at presentation was 15 months. Three patients had acute onset while the rest had insidious onset of symptoms. Out of the 22 patients, 11 (50% had motor weakness as the first symptom, 13 (59% were bedridden and 19 (86.4% had bladder involvement at presentation. Thirteen patients had fistulae in thoracic spine, whereas eight had fistulae in the lumbar spine. All had a favorable outcome in the form of at least non-progression of gait disability (14 had improvement while 8 had stabilized. The improvement was non-significantly associated with younger age, acute onset, ambulant status and fistula below T9. It was inversely associated with pain as the first symptom and fluctuant clinical course. Conclusion: Surgical occlusion of SDAVF is usually associated with either improvement or stabilization of motor weakness.

  14. In phyllodes tumour of the breast expression of c-kit but not of ALDH1A1 is associated with adverse clinico-pathological features.

    Science.gov (United States)

    Chougule, Abhijit; Bal, Amanjit; Das, Ashim; Kohli, Pavneet Singh; Singh, Gurpreet

    2016-12-01

    Attempts at identification of an ideal prognostic/predictive biomarker in phyllodes tumour (PT) have not been fruitful so far. Studies evaluating c-kit expression in PT have shown contradictory results. Recently aldehyde dehydrogenase 1A1 (ALDH1A1) was proposed as a stem cell marker for malignant PT but its expression has not been studied in benign and borderline tumours. We aimed to evaluate expression and prognostic significance of c-kit and ALDH1A1 in different grades of PT. Epithelial and stromal c-kit and ALDH1A1 expression were studied in 104 PT cases (86 primary and 18 recurrent tumours) and compared with different clinico-pathological features and recurrence rates. Stromal c-kit expression at 1 % cutoff correlated with increasing tumour grade, larger tumour size, hypercellularity, nuclear atypia, stromal overgrowth, infiltrative margins and mitotic count. These associations, however, were lost with higher (5 or 10 %) cutoffs. Conversely, decreased c-kit expression in the epithelial component correlated with increasing tumour grade, regardless of the cutoffs used. Stromal ALDH1A1 expression did not have significant associations with tumour grade or other adverse clinico-pathological features, regardless of different cutoffs. None of the cases showed significant epithelial ALDH1A1 expression. Expression of c-kit was associated with poorer overall survival (p = 0.011), while ALDH1A1 expression was associated with shorter recurrence-free survival (p = 0.036). In conclusion, c-kit expression was associated with higher tumour grade and adverse clinico-pathological features. However, these associations are cutoff dependent, partly explaining the variability in previously reported studies. ALDH1A1 expression did not have significant correlations with tumour grade and adverse clinico-pathological variables.

  15. Bilateral submandibular gland aplasia with clinico-radiological mass due to prolapsing sublingual salivary tissue through mylohyoid boutonniere: a case report and review.

    Science.gov (United States)

    Ahmed, M; Strauss, M; Kassaie, A; Shotelersuk, V; DeGuzman, R

    2009-02-01

    Aplasia of major salivary glands is very rare. Compensatory hypertrophy of the rest of the glands can result in clinico-radiological masses. We present a report of a rare case of non-syndromic bilateral submandibular gland aplasia with hypertrophied sublingual salivary tissue, the latter herniating through mylohyoid boutonnière to present as a palpable mass on the left side with corresponding CT findings. Multiplanar evaluation is emphasised by utilizing multidetector CT.

  16. Clinico-pathological features of bladder carcinoma in women in Pakistan and smokeless tobacco as a possible risk factor

    Directory of Open Access Journals (Sweden)

    Rafique Muhammad

    2005-08-01

    Full Text Available Abstract Background Bladder carcinoma is one of the common urological malignancies occurring worldwide in both sexes. Use of smokeless tobacco by women is common in rural areas of Pakistan. The clinico-pathological features of bladder carcinoma in women and association of smokeless tobacco as a possible risk factor for bladder carcinoma has not been well described in the literature. The objective of the study was to determine the clinico-pathological features of histologically confirmed bladder carcinoma in women and to investigate the role of smokeless tobacco use as a possible risk factor for its development. Patients and methods Of the 204 patients (160 male and 44 female M:F ratio 3.6:1 of newly diagnosed bladder carcinoma treated at Nishtar Medical College Hospital Multan from January 1998 to December 2004, the 44 female patients were evaluated with respect to age, clinical presentation, cystoscopic findings, histopathological reports and possible etiological factors. Data were collected and prospectively updated at the time of discharge from hospital and during follow-up in urology out-patient clinic. Results Transitional cell carcinoma accounted for all of the bladder carcinoma in women. Median age of the patients was 55 years and 68% patients were under 60 years of age. Majority of patients (88% presented with hematuria. Eleven (25% patients had superficial (pTa/pT1 while 33 (75% patients had muscle invasive (T2–T4 bladder carcinoma. Most (81% superficial tumors were papillary while muscle invasive tumors had solid configuration at cystoscopy. Of these, 21 (47% patients had long history of smokeless tobacco use (chewable or moist snuff. Conclusion Transitional cell carcinoma is the most common bladder malignancy in women in Pakistan. Many women with bladder carcinoma had long history of use of smokeless tobacco. Majority of patients presented with hematuria and were under 60 years of age. At the time of diagnosis 75% women had muscle

  17. Clinico-pathological studies on the effects of preoperative hyperthermo-chemo-radiotherapy for advanced esophageal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Tsutomu; Ide, Hiroko; Eguchi, Reiki (Tokyo Women' s Medical Coll. (Japan)) (and others)

    1991-12-01

    We report clinico-pathological studies on the effect of preoperative hyperthermia and chemotherapy combined with radiotherapy (HCR) for progress of the local curability of advanced esophageal carcinoma. The subjects of these studies were 17 patients who underwent subtotal esophagectomy after preoperative irradiation of 40 Gy from 1980 to 1989, of which 8 patients had HCR, 6 patients irradiation only (R), 3 patients both irradiation and chemotherapy (CR). The clinical response rate of the patients with R or CR was 33% (PR 3, MR 3, NC 3), and the histological effective (Ef{sub 3} or Ef{sub 2}) rate was 56% (Ef{sub 3} 1, Ef{sub 2} 4, Ef{sub 1} 4). The clinical response rate of the patients with HCR was 88% (PR 7, MR 1), and the histological effective rate was 100% (Ef{sub 3} 1, Ef{sub 2} 7). HCR was more effective than R or CR for the local lesion of esophageal carcinoma histopathologically (p<0.05). However, the survival rate of patients with HCR was similar to R and CR, respectively. These results suggest that further improvement of the heating methods and the methods of combining hyperthermia with irradiation and chemotherapy is needed. (author).

  18. The relationship between clinico-biochemical characteristics and psychiatric distress in young women with polycystic ovary syndrome.

    Science.gov (United States)

    Adali, E; Yildizhan, R; Kurdoglu, M; Kolusari, A; Edirne, T; Sahin, H G; Yildizhan, B; Kamaci, M

    2008-01-01

    The relationship between clinico-biochemical characteristics and self reported psychological parameters in 42 women with polycystic ovary syndrome (PCOS) and 42 age-matched healthy controls was examined. The General Health Questionnaire was used (GHQ-12) to ascertain emotional distress and the Beck Depression Inventory (BDI) to determine depressive symptoms. Emotional distress, depressive symptoms, hirsutism score, body mass index (BMI), waist-to-hip ratio (WHR), luteinizing hormone/follicle-stimulating hormone ratio, serum total testosterone, dehydroepiandrosterone sulphate levels and the insulin resistance index were significantly greater in women with PCOS than in healthy women. The BDI and GHQ-12 scores of the women with PCOS were significantly higher than those of the control group (BDI, 11.69 +/- 9.49 vs 5.80 +/- 4.58; GHQ-12, 3.38 +/- 3.38 vs 1.54 +/- 1.97, respectively), and BMI and WHR were positively correlated with the BDI and GHQ-12 scores. Clinicians should be aware of the increased risk of emotional distress and depression in women with PCOS, especially those who are obese, and of the need to screen these patients for such symptoms.

  19. A CLINICO- HEMATOLOGICAL STUDY IN CASES OF PANCYTO PENIA: CORRELATION OF AUTOMATED CELL COUNTER PARAMETERS IN VARIOUS ETIOLOGIES

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    Soma

    2013-05-01

    Full Text Available ORIGINAL ARTICLE Journal of Evolution of Medical and Dental Sciences / Volume 2/ Issue 22/ June 3, 2013 Page 4013 A CLINICO- HEMATOLOGICAL STUDY IN CASES OF PANCYTO PENIA: CORRELATION OF AUTOMATED CELL COUNTER PARAMETERS IN VARIOUS ETIOLOGIES Soma Yadav 1 , Rashmi Kushwaha 2 , Kamal Aggrawal 3 , A.K Tripathi 4 , U.S Singh 5 , Ashutosh Kumar 6 . 1. Junior Resident, Department. Of pathology, King George’s Medical Uni versity 2. Assistant Professor, Department. Of pathology, King George’s Medical University 3. Professor, Department. Of pathology, King George’s Medical University 4. Professor and Head, Department. Of Clinical Hematol ogy, King George’s Medical University 5. Professor, Department. Of pathology, King George’s Medical University 6. Professor and officer in charge, Lymphoma- Leukemia Lab, Department. Of pathology, King George’s Medic al University. CORRESPONDING AUTHOR: Dr. Rashmi Kushwaha, King George’s Medical University, Lucknow. E-mail: docrashmi27@yahoo.co.in

  20. Clinico-pathological and therapeutic evaluation of Black Bengal goats (Capra hircus) infested with Psoroptes cuniculi mange.

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    Kumar, Mritunjay; Pal, Bhabatosh; Purkayastha, R D; Roy, Joybrath

    2016-03-01

    The objective of the present study was to investigate the clinico-pathological changes and therapeutic evaluation of gamma-benzene hexachloride and cetrimide along with vit A, D3, E and H in Black Bengal goat infested Psoroptes cuniculi mange. The study was conducted on 14 Black Bengal goats; 6 clinically infested with Psoroptes mange (group I) and 8 healthy goats (group II). Haemato-biochemical profile viz., haemoglobulin concentration, packed cell volume, total leukocyte count, albumin and albumin globulin ratio revealed significantly (P < 0.05) decreased level; whereas, globulin, alanine aminotransaminase, aspartate aminotransaminase, serum creatinine and blood urea nitrogen level were significantly (P < 0.05) increased in goats of group I animals as compared to healthy control (group II) on day 0. Gamma-benzene hexachloride and cetrimide along with adjunct therapy (group I) showed parasitological recovery on day 21 while complete elimination of clinical signs observed on day 28 of post-therapy in all clinical cases.

  1. Recurrent pyogenic cholangitis: clinico-pathologic correlation of focal attenuation differences on multi-phasic spiral CT

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    Jeong, Jun Yong; Han, Joon Koo; Kim, Tae Kyoung; Kim, Seog Joon; Kim, Hyun Bum; Choi, Byung Ihn [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    2002-02-01

    To determine the clinical and the pathologic significance of the focal attenuation differences (FAD) and bile duct wall enhancement occurring in recurrent pyogenic cholangitis (RPC) and seen at multiphasic spiral CT. Among the multiphasic (non-contrast, arterial and portal or delayed phase) spiral CT findings of 60 consecutive patients, two types of FAD were noted during the non-contrast phase. These were Type A (iso) and Type B (low attenuation), and their distribution pattern (lobar versus patchy, multifocal) and the and the presence or absence of bile duct wall enhancement were recorded. The radiologic findings were correlated with the clinical and pathologic findings. Two types of FAD were noted in 40 of the 60 patients. Active in flammation was present in 19 of the 27 with Type-A and in ten of the 15 in whom the presence of RPC was pathologically proven. Ten of the 13 with Type-B FAD were in a subclinical state, and nine of the ten in whom RPC was pathologically proven had chronic inflammation. Among 20 patients who did not have FAD, RPC was subclinical in 18 and dormant in nine of the eleven in whom its presence was pathologically proven (p<0.001). Clinico-pathologic correlation with bile duct wall enhancement and the distribution pattern of FAD showed no statistical significance. The inflammatory activity of RPC can be predicted by analysis of the FAD seen at multiphasic spiral CT.

  2. An epidemiological and clinico-histopathological study of leprosy in semi-urban area under Pimpri Chinchwad Municipal Corporation in Pune district of Maharashtra

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    Alia A Rizvi

    2015-01-01

    Full Text Available Background: Despite having been declared eliminated in December 2005 from India as a public health problem, the prevalence of leprosy exceeds 1/10,000 population in certain districts/states of India. A spurt in its prevalence by 60% - from 0.74 to 1.18 within 1-year from 2012 to 2013 in the area under Pimpri Chinchwad Municipal Corporation (PCMC of Pune district of Maharashtra, wherein our institution is located, motivated us to carry out this study. Aims and Objectives: This prospective study entailed recording of the epidemiological data of cases of leprosy and carrying out correlation of their clinical and histopathological diagnoses as per Ridley–Jopling scale along with inclusion of indeterminate and pure neuritic types. Materials and Methods: Eighty fresh untreated patients hailing from areas under PCMC–in whom leprosy was clinically considered to be either the diagnosis or the differential diagnosis-reporting to the department of dermatology of our tertiary care hospital were enrolled. Their age, sex, and clinical findings were recorded on a proforma. Slit skin and scrape smear were stained by the Ziehl–Neelsen method. Punch biopsies–processed and stained by hematoxylin and eosin and Fite-Faraco method for morphological assessment and identification of the lepra bacilli, respectively–were evaluated histopathologically and a clinico-histopathological correlation, attempted. Results: Male to female ratio of the study patients was 2.3:1; their age ranged from 14 to 74 (mean, 36.67 years. The overall clinico-histopathological concordance observed was 70%. Five cases of indeterminate leprosy (IL emerged on histopathological examination from among the nine skin biopsies on patients of dermatoses mimicking leprosy (pityriasis alba, postinflammatory hypopigmentation, nevus depigmentosus, etc.. Conclusion: This study enabled us to detect additional cases of IL (from among dermatoses mimicking leprosy and led to more accurate typing

  3. Loss of keratin 8 phosphorylation leads to increased tumor progression and correlates with clinico-pathological parameters of OSCC patients.

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    Hunain Alam

    Full Text Available BACKGROUND: Keratins are cytoplasmic intermediate filament proteins expressed in tissue specific and differentiation dependent manner. Keratins 8 and 18 (K8 and K18 are predominantly expressed in simple epithelial tissues and perform both mechanical and regulatory functions. Aberrant expression of K8 and K18 is associated with neoplastic progression, invasion and poor prognosis in human oral squamous cell carcinomas (OSCCs. K8 and K18 undergo several post-translational modifications including phosphorylation, which are known to regulate their functions in various cellular processes. Although, K8 and K18 phosphorylation is known to regulate cell cycle, cell growth and apoptosis, its significance in cell migration and/or neoplastic progression is largely unknown. In the present study we have investigated the role of K8 phosphorylation in cell migration and/or neoplastic progression in OSCC. METHODOLOGY AND PRINCIPAL FINDINGS: To understand the role of K8 phosphorylation in neoplastic progression of OSCC, shRNA-resistant K8 phospho-mutants of Ser73 and Ser431 were overexpressed in K8-knockdown human AW13516 cells (derived from SCC of tongue; generated previously. Wound healing assays and tumor growth in NOD-SCID mice were performed to analyze the cell motility and tumorigenicity respectively in overexpressed clones. The overexpressed K8 phospho-mutants clones showed significant increase in cell migration and tumorigenicity as compared with K8 wild type clones. Furthermore, loss of K8 Ser73 and Ser431 phosphorylation was also observed in human OSCC tissues analyzed by immunohistochemistry, where their dephosphorylation significantly correlated with size, lymph node metastasis and stage of the tumor. CONCLUSION AND SIGNIFICANCE: Our results provide first evidence of a potential role of K8 phosphorylation in cell migration and/or tumorigenicity in OSCC. Moreover, correlation studies of K8 dephosphorylation with clinico-pathological parameters of OSCC

  4. Low grade Endometrial Stromal Sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases

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    Shariat Mamak

    2006-08-01

    Full Text Available Abstract Background Endometrial stromal sarcoma (ESS is a rare disease with probably less than 700 new cases in the USA or Europe per year. The aim of this study was to evaluate the behavior of low-grade endometrial stromal sarcoma (LGESS in relation to their clinical and pathological features and to identify possible prognostic factors. Patients and methods Fourteen patients with histologically proven ESS were included in the analysis. Endometrial stromal sarcoma is characterized by proliferations composed of cells with Endometrial stromal cell differentiation. Low-grade endometrial stromal sarcoma has an infiltrating margin and typically show extensive worm-like vessel invasion. Results The median age was 44.35 ± 6 years. The most common presenting symptom was vaginal bleeding, occurring in twelve patients (86%. Diagnosis was made through Fractional dilatation and curettage in four patients (28.5%. Eight patients had a total abdominal hysterectomy and salpingo-ophorectomy (57%. Radiotherapy as adjuvant therapy was administered to four patients (28.5%. The median follow-up time was 45.6 months (range 24–84. The median overall survival of the 14 patients was 45.35 ± 21 months (range 20–83. Three of 14 patients demonstrated a recurrence of disease at 9, 72, and 96 months respectively. The recurrent diseases were treated with surgery, chemotherapy, and radiotherapy. No patient died of the disease. Clinico-pathological parameters did not significantly differ between patients with and without recurrence, but patients with no myometrial invasion and low mitotic count Conclusion Five-year survival rate was 93%. Survival probabilities were calculated by the product limit method of Kaplan and Meier that showed, patients with no myometrial invasion and low mitotic count

  5. Clinico-pathological impact of cytogenetic subgroups in B-cell chronic lymphocytic leukemia: Experience from India

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    PS Kadam Amare

    2013-01-01

    Full Text Available Background: The present study of 238 B-cell Chronic Lymphocytic Leukemia (B-CLL patients were undertaken to seek the prevalence and to evaluate clinico-pathological significance of recurrent genetic abnormalities such as del(13q14.3, trisomy 12, del(11q22.3 (ATM, TP53 deletion, del(6q21 and IgH translocation/deletion. Materials and Methods: We applied interphase - fluorescence in situ hybridization (FISH on total 238 cases of B-CLL. Results: Our study disclosed 69% of patients with genetic aberrations such as 13q deletion (63%, trisomy 12 (28%, 11q deletion (18%, 6q21 deletion (11% with comparatively higher frequency of TP53 deletion (22%. Deletion 13q displayed as a most frequent sole abnormality. In group with coexistence of ≥2 aberrations, 13q deletion was a major clone indicating del(13q as a primary event followed by 11q deletion, TP53 deletion, trisomy 12, 6q deletion as secondary progressive events. In comparison with del(13q, trisomy 12, group with coexistence of ≥2 aberrations associated with poor risk factors such as hyperleukocytosis, advanced stage, and multiple nodes involvement. In a separate study of 116 patients, analysis of IgH abnormalities revealed either partial deletion (24% or translocation (5% and were associated with del(13q, trisomy 12, TP53 and ATM deletion. Two of 7 cases had t(14;18, one case had t(8;14, and four cases had other variant IgH translocation t(?;14. Conclusion: Detail characterization and clinical impact are necessary to ensure that IgH translocation positive CLL is a distinct pathological entity. Our data suggests that CLL with various cytogenetic subsets, group with coexistence of ≥2 aberrations seems to be a complex cytogenetic subset, needs more attention to understand biological significance and to seek clinical impact for better management of disease.

  6. Clinico-epidemiological profile of tobacco users attending a tobacco cessation clinic in a teaching hospital in Bangalore city

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    George D′Souza

    2012-01-01

    Full Text Available Background: Tobacco-attributable mortality in India is estimated to be at least 10%. Tobacco cessation is more likely to avert millions of deaths before 2050 than prevention of tobacco use initiation. Objective: To describe the clinico-epidemiological profile of attendees of a tobacco cessation clinic in a teaching hospital in Bangalore city. Materials and Methods: A descriptive study of 189 attendees seen over 2 years in the Tobacco Cessation Clinic of a tertiary-care teaching hospital in Bangalore, with information on socio demographic characteristics, tobacco-use details, nicotine dependence, family/medical history, past quit attempts, baseline stage-of-change, and treatment initiated. Results: Only 5% were ′walk-in′ patients; 98% of attendees were smokers; 97% were males. The mean (±SD age of attendees was 48.0 (±14.0 years. Most participants were married (88%, and predominantly urban (69%. About 62% had completed at least 8 years of schooling. Two-thirds of smokers reported high levels of nicotine dependence (Fagerström score >5/10. About 43% of patients had attempted quitting earlier. Four-fifths (79% of tobacco-users reported a family member using tobacco. Commonly documented comorbidities included: Chronic respiratory disease (44%, hypertension (23%, diabetes (12%, tuberculosis (9%, myocardial infarction (2%, stroke (1%, sexual dysfunction (1% and cancer (0.5%. About 52% reported concomitant alcohol use. At baseline, patients′ motivational stage was: Precontemplation (14%, contemplation (48%, preparation/action (37% and maintenance (1%. Treatment modalities started were: Counseling alone (41%, nicotine replacement therapy alone (NRT (34%, medication alone (13%, and NRT+medication (12%. Conclusions: This is the first study of the baseline profile of patients attending a tobacco cessation clinic located within a chest medicine department in India. Important determinants of outcome have been captured for follow-up and prospective

  7. PAH exposure biomarkers are associated with clinico-chemical changes in the brick kiln workers in Pakistan.

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    Kamal, Atif; Malik, Riffat Naseem; Martellini, Tania; Cincinelli, Alessandra

    2014-08-15

    In this study we investigated the clinico-chemical parameters and the level of exposure of brick kiln workers to polycyclic aromatic hydrocarbons (PAHs) in Punjab (Pakistan). The brick kiln workers and a non-occupationally exposed group were recruited for comparative analysis of urinary biomarkers of PAH exposure (i.e. 1-hydroxypyrene (1-OHPyr), α-naphthol and β-naphthol) and blood level of superoxide dismutase (SOD), as a biomarker of oxidative stress and other hematologic parameters. Questionnaires were used to document information on socio-demographic characteristics of all the subjects. The analysis of urinary biomarkers showed higher median concentrations of 1-OHPyr, and α- and β-naphthols in brick kiln workers (1.53, 3.65 and 1.53 μmol/mol-Cr, respectively) than non-occupationally exposed group (0.62, 0.64 and 0.66 μmol/mol-Cr, respectively). The 1-OHPyr in brick kiln workers was above the occupational exposure level. Among the clinical parameters of brick kiln workers, hemoglobin (Hb) and red blood cells (RBCs) were very low and closely associate with 1-OHPyr and β-naphthol. Additionally, the white blood cells (WBCs) and superoxide dismutase (SOD) were also elevated in brick kiln workers, which suggested inflammatory symptoms and high oxidative stress. The results show that regardless of possibly being affected by the poor nutrition, the anemic state and hematological changes observed in brick kiln workers may be associated with their exposure to smoke present in the environment of brick kilns.

  8. Prediction for steatosis in type-2 diabetes: clinico-biological markers versus {sup 1}H-MR spectroscopy

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    Guiu, Boris; Krause, Denis; Cercueil, Jean-Pierre [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Radiology, 2 boulevard Marechal de Lattre de Tassigny, BP 77908, Dijon (France); Crevisy-Girod, Elodie [CHU (University Hospital), Department of Endocrinology, Diabetology, and Metabolic Diseases, BP 77908, Dijon (France); Binquet, Christine [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Biostatistics and Medical Informatics, BP 77908, Dijon (France); Duvillard, Laurence [University of Burgundy, INSERM U866, BP 87900, Dijon (France); Masson, David [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Biochemistry, BP 77908, Dijon (France); Lepage, Come; Hamza, Samia; Minello, Anne; Hillon, Patrick [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Hepatology, BP 77908, Dijon (France); Verges, Bruno; Petit, Jean-Michel [University of Burgundy, INSERM U866, BP 87900, Dijon (France); CHU (University Hospital), Department of Endocrinology, Diabetology, and Metabolic Diseases, BP 77908, Dijon (France)

    2012-04-15

    The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI) are clinico-biological scores of steatosis validated in general or selected populations. Serum adiponectin (s-adiponectin) and retinol binding protein 4 (s-RBP4) are adipokines that could predict liver steatosis. We investigated whether the Steatotest, FLI, HSI, s-adiponectin and s-RBP4 could be valid predictors of liver steatosis in type-2 diabetic (T2D) patients. We enrolled 220 consecutive T2D patients. Reference standard was 3.0 T {sup 1}H-MR spectroscopy (corrected for T1 and T2 decays). Intraclass correlation coefficients (ICCs), Kappa statistic measures of agreement, receiver operating characteristic (ROC) curves were assessed. Median liver fat content was 91 mg triglyceride/g liver tissue (range: 0-392). ICCs among the Steatotest, FLI, HSI, s-adiponectin, s-RBP4 and spectroscopy were low: 0.384, 0.281, 0.087, -0.297 and 0.048. Agreement between scores and spectroscopy was poor (Kappa range: 0.042-0.281). The areas under the ROC curves were low: 0.674, 0.647, 0.637, 0.616 and 0.540. S-adiponectin and s-RBP4 levels were strongly related to the presence of diabetic nephropathy (P = 0.0037 and P = 0.004; Mann-Whitney). The SteatoTest, FLI, HSI, s-adiponectin, s-RBP4 are not valid predictors of steatosis in T2D patients. Clino-biological markers cannot replace {sup 1}H-MR spectroscopy for the assessment of liver fat in this population. (orig.)

  9. Clinico-pathological correlation of E-cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: An immunohistochemical study

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    Mehendiratta, Monica; Solomon, Monica Charlotte; Boaz, Karen; Guddattu, Vasudeva; Mohindra, Aashima

    2014-01-01

    Background: Recent studies have indicated that although malignant cells at the invasive tumor front, bare morphological resemblance to the cells at central portion of the tumor, their molecular character differs significantly. E-cadherin is a cell-cell adhesion molecule that connects epithelial cells. This study attempts to correlate the E-cadherin expression at the invasive tumor front with tumor differentiation along with its clinico-pathological parameters. Materials and Methods: Immunohistochemical staining with E-cadherin was carried out on archival cases of primary oral squamous cell carcinomas (n = 30). The E-cadherin expression at the invasive tumor front was analyzed and was linked to clinico-pathological parameters including patient prognosis. Results: The downregulation of E-cadherin expression at the invasive tumor edge when compared with patient's prognosis yielded a significant correlation (P = 0.041) but its correlation with the degree of differentiation determined was not significant (P = 0.27). Also, its association with tumor size and lymph node status was negative. Conclusions: Loss of E-cadherin expression at the invasive tumor front is an important event in the progression of oral squamous cell carcinomas. Tumors with a loss of expression of E-cadherin are those which had a poor prognosis PMID:25328302

  10. Epidemiological, Clinico-Pathological Profile and Management of Colorectal Carcinoma in a Tertiary Referral Center of Eastern India

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    Shyamal Kumar Halder

    2013-01-01

    Full Text Available Background: The colorectal carcinoma is a common cancer in males and in females and second most common cause of death in Europe and third commonest cause in the United States. Recent Indian study shows that there is a significant increase in incidence of colonic carcinoma but the incidence of rectal carcinoma remains steady. Aims and Objectives: This prospective study was undertaken to assess the clinico-pathological profile and management of colorectal malignancy in a tertiary referral institute of eastern India and to compare the above data with the data from the western world. Material and Methods: The patients admitted with the diagnosis of colorectal carcinoma in IPGME and R (SSKM, a tertiary hospital in eastern India, between January 2006 and December 2010, were included in this study. These patients were prospectively analyzed for age, sex, site of the lesion, clinical presentations, nature of the growth and types of surgery performed. Results: 192 patients were included in this study of which 78 patients were of younger age group (35 years. The mean age of this series was 44.1 years. The male to female ratio of younger and older group was 1.68:1 and 1.85:1 respectively. Reetal bleeding was the commenest symptom irrespective of age and sex. Pain in abdomen (39.7% and intestinal obstruction (21.8% were the predominant presenting features in the patients of younger group whereas weight loss was commonest presenting feature in the patients of older age group. Most common histological type, irrespective of age, was adenocarcinoma (93.8%. Overall, right sided colonic growth was more common in females while rectum was the commonest site of affection in males. The patients of younger age group presented in advanced stage like Duke’s C and Duke’s D. Conclusions: The younger patients are diagnosed with colorectal carcinoma. Cancer of right colon is more common than that of left. The younger patients present more often with abdominal pain and

  11. Clinico-pathological analysis of renal cell carcinoma demonstrates decreasing tumour grade over a 17-year period

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    Nason, Gregory J.; McGuire, Barry B.; Kelly, Michael E.; Murphy, Theodore M.; Looney, Aisling T.; Byrne, Damien P.; Mulvin, David W.; Galvin, David J.; Quinlan, David M.; Lennon, Gerald M.

    2014-01-01

    Introduction: Renal cell carcinoma (RCC) represents about 3% of adult malignancies in Ireland. Worldwide there is a reported increasing incidence and recent studies report a stage migration towards smaller tumours. We assess the clinico-pathological features and survival of patients with RCC in a surgically treated cohort. Methods: A retrospective analysis of all nephrectomies carried out between 1995 and 2012 was carried out in an Irish tertiary referral university hospital. Data recorded included patient demographics, size of tumour, tumour-node-metastasis (TNM) classification, operative details and final pathology. The data were divided into 3 equal consecutive time periods for comparison purposes: Group 1 (1995–2000), Group 2 (2001–2006) and Group 3 (2007–2012). Survival data were verified with the National Cancer Registry of Ireland. Results: In total, 507 patients underwent nephrectomies in the study period. The median tumour size was 5.8 cm (range: 1.2–20 cm) and there was no statistical reduction in size observed over time (p = 0.477). A total of 142 (28%) RCCs were classified as pT1a, 111 (21.9%) were pT1b, 67 (13.2%) were pT2, 103 (20.3%) were pT3a, 75 (14.8%) were pT3b and 9 (1.8%) were pT4. There was no statistical T-stage migration observed (p = 0.213). There was a significant grade reduction over time (p = 0.017). There was significant differences noted in overall survival between the T-stages (p < 0.001), nuclear grades (p < 0.001) and histological subtypes (p = 0.022). Conclusion: There was a rising incidence in the number of nephrectomies over the study period. Despite previous reports, a stage migration was not evident; however, a grade reduction was apparent in this Irish surgical series. We can demonstrate that tumour stage, nuclear grade and histological subtype are significant prognosticators of relative survival in RCC. PMID:24839483

  12. Visceral Leishmaniasis in Southwestern Iran: A Retrospective Clinico-Hematological Analysis of 380 Consecutive Hospitalized Cases (1999-2014).

    Science.gov (United States)

    Sarkari, Bahador; Naraki, Tahereh; Ghatee, Mohammad Amin; Abdolahi Khabisi, Samaneh; Davami, Mohammad Hassan

    2016-01-01

    Visceral Leishmaniasis (VL) is an endemic parasitic disease and remains as a major health concern in southwestern Iran. The current study describes clinico-hematological, epidemiological and therapeutic features of VL cases, admitted to university-affiliated hospitals, during 1999-2014 in Fars province, southwestern Iran. A total of 380 VL cases were recorded during a 16 years period, giving an average annual admission of 23.75 cases/year in which 217 (57.1%) were male and 163 (42.9%) were female. Mean age of the patients was 3.7 years. The majority of the cases (91.5%) were ≤ 5 years old. Bone-marrow aspiration detected Leishmania amastigotes only in 26.6% of cases. Fever (98.1%), abdominal protrusion (65.1%) and hepatosplenomegaly (63.7%) were the most common clinical presentations of the patients. Pancytopenia was noted in 43.1, anemia in 87.3 and thrombocytopenia in 64% of cases. Increase in the level of AST (aspartate aminotransferase), ALT (alanine aminotransferase), alkaline phosphatase, LDH (lactate dehydrogenase) and CRP (C-Reactive Proteins) were seen in 84.9, 53.6, 44.4, 72.5 and 83.1% of cases, respectively. Mortality was noted in 5.3% of cases. Deranged haemato-biochemical parameters including total and direct bilirubin, PLT (platelet) and pancytopenia were significantly contributed to mortality from VL. Moreover, clinical features such as severe splenomegaly as well as bacterial infections were meaningfully contributed to death from VL. The majority of patients (74.9%) were treated with meglumine antimoniate. Amphotericin B was administrated in 59 of cases, 11 of them were initially treated with meglumine antimoniate with a shift to amphotericin B, because of treatment failure. Findings of the current study demonstrated that VL is present in southwest of Iran with a fairly continual rate during the last 16 years period. Deranged haemato-biochemical parameters along with severe splenomegaly contributed to mortality from VL.

  13. Metastatic cryptoseminoma: radiologic-pathologic correlation; Criptosseminoma metastatico: correlacao radiologico-patologica

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    Barbosa Junior, Eduardo Jose Mortani [Universidade da Pennsylvania (United States). Dept. de Imagem Cardiotoracica]. E-mail: Eduardo-mortani@uol.com.br; Jayanthi, Shri Krishna; Menezes, Marcos Roberto de [Universidade de Sao Paulo (USP), SP (Brazil). Hospital das Clinicas. Servico de Radiologia de Emergencia; Cerri, Giovanni Guido [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Medicina. Dept. de Radiologia

    2007-07-01

    We describe a case of a young male with a rapid-growing abdominal mass whose diagnosis required the correct interpretation of imaging findings (computerized tomography and sonography) along with clinical-radiologic reasoning, in order to arrive at the correct diagnostic hypothesis, and, hence, recommend optimal therapy. We hereby present a brief review of the literature and a radiologic-pathologic correlation of this extremely rare entity: large metastatic cryptoseminoma originated from a small seminoma in a cryptorchid left pelvic testis. (author)

  14. A clinico-radiological phenotype of voltage-gated potassium channel complex antibody-mediated disorder presenting with seizures and basal ganglia changes.

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    Hacohen, Yael; Wright, Sukhvir; Siddiqui, Ata; Pandya, Nikki; Lin, Jean-Pierre; Vincent, Angela; Lim, Ming

    2012-12-01

    In childhood, central nervous system (CNS) presentations associated with antibodies to voltage-gated potassium channel (VGKC) complex include limbic encephalitis, status epilepticus, epileptic encephalopathy, and autistic regression. We report the cases of two individuals (a 6-year-old male and an 11-year-old female) who presented with an acute-onset explosive seizure disorder with positive VGKC complex antibodies and bilateral basal ganglia changes on magnetic resonance imaging (MRI). Both patients made a complete clinical recovery, without immunotherapy, with resolution of the MRI changes and normalization of the antibody levels. Extended antibody testing, including testing for leucine-rich glioma-inactivated 1 (LGI1), contactin-associated protein 2, and contactin-2 was negative. This could suggest that the clinico-radiological phenotype in our patients may in fact be associated with a novel autoreactive target(s) within the VGKC complex, as may be the case in other children with VGKC complex-mediated CNS disorders.

  15. MICrocephaly, disproportionate pontine and cerebellar hypoplasia syndrome: A clinico-radiologic phenotype linked to calcium/calmodulin-dependent serine protein kinase gene mutation

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    Rashid Saleem

    2013-01-01

    Full Text Available MICrocephaly, disproportionate pontine and cerebellar hypoplasia (MICPCH syndrome, a rare X-linked disorder, generally seen in girls, is characterized by neurodevelopmental delay, microcephaly, and disproportionate pontine and cerebellar hypoplasia. It is caused by inactivating calcium/calmodulin-dependent serine protein kinase (CASK gene mutations. We report a 2-year-old girl with severe neurodevelopmental delay, microcephaly, minimal pontine hypoplasia, cerebellar hypoplasia, and normal looking corpus callosum, with whom the conventional cytogenetic studies turned out to be normal, and an array-comparative genomic hybridization (a-CGH analysis showed CASK gene duplication at Xp11.4. Our case highlights the importance of using clinico-radiologic phenotype to guide genetic investigation and it also confirms the role of a-CGH analysis in establishing the genetic diagnosis of MICPCH syndrome, when conventional cytogenetic studies are inconclusive.

  16. Japanese encephalitis associated acute encephalitis syndrome cases in West Bengal, India: A sero-molecular evaluation in relation to clinico-pathological spectrum.

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    Sarkar, Arindam; Datta, Somenath; Pathak, Bani K; Mukhopadhyay, Subhra K; Chatterjee, Shyamalendu

    2015-08-01

    Japanese encephalitis (JE) is a major public health problem in Asia and worldwide and it is responsible mainly for viral acute encephalitis syndrome (AES). The sole etiologic agent of JE is Japanese encephalitis virus (JEV). Although JE/AES cases have been regarded traditionally as a disease of children, a growing number of patients with JE/AES cases are also seen in the adult age group every year in the state of West Bengal, India in spite of vaccination. Therefore, a systematic study was performed to differentiate and characterize the clinico-pathological parameters and viral diversity among the patients of different age groups. Viral diversity was also evaluated from the JE/AES cases, depending on their disease severity. A total of 441 JE/AES cases were included in this study. By MAC-ELISA, 111 samples were found JEV IgM positive and among the IgM negative cases, 26 samples were found RT-PCR positive against JEV infection. Neck rigidity, abnormal behavior, convulsion, protein in CSF, WBC in CSF, and aspartate transaminase in blood differed significantly among the patients of pediatric-adolescent and adult group in both IgM positive and RT-PCR positive cases. Viral diversity was increased significantly in the pediatric-adolescent group compared to adult patients. Interestingly, with the rise in disease severity the viral diversity was found to be increased among the patients, irrespective of their age distribution. Based on clinico-pathological parameters and analysis of viral diversity, it can be concluded that viral diversity which occurs naturally is likely to affect disease severity, especially in the patients of pediatric-adolescent group. © 2015 Wiley Periodicals, Inc.

  17. CROP - The Clinico-Radiologico-Ophthalmological Paradox in Multiple Sclerosis: Are Patterns of Retinal and MRI Changes Heterogeneous and Thus Not Predictable?

    Directory of Open Access Journals (Sweden)

    Fahmy Aboulenein-Djamshidian

    Full Text Available To date, no direct scientific evidence has been found linking tissue changes in multiple sclerosis (MS patients, such as demyelination, axonal destruction or gliosis, with either steady progression and/or stepwise accumulation of focal CNS lesions. Tissue changes such as reduction of the retinal nerve fiber layer (RNFL and the total macular volume (TMV, or brain- and spinal cord atrophy indicates an irreversible stage of tissue destruction. Whether these changes are found in all MS patients, and if there is a correlation with clinical disease state, remains controversial. The objective of our study was to determine, whether there was any correlation between the RNFL or TMV of patients with MS, and: (1 the lesion load along the visual pathways, (2 the ratios and absolute concentrations of metabolites in the normal-appearing white matter (NAWM, (3 standard brain atrophy indices, (4 disease activity or (5 disease duration.28 MS patients (RRMS, n = 23; secondary progressive MS (SPMS, n = 5 with moderately-high disease activity or long disease course were included in the study. We utilised: (1 magnetic resonance imaging (MRI and (2 -spectroscopy (MRS, both operating at 3 Tesla, and (3 high-resolution spectral domain-OCT with locked reference images and eye tracking mode to undertake the study.There was no consistency in the pattern of CNS metabolites, brain atrophy indices and the RNFL/TMV between individuals, which ranged from normal to markedly-reduced levels. Furthermore, there was no strict correlation between CNS metabolites, lesions along the visual pathways, atrophy indices, RNFL, TMV, disease duration or disability.Based on the findings of this study, we recommend that the concept of 'clinico-radiologico paradox' in multiple sclerosis be extended to CROP-'clinico-radiologico-ophthalmological paradox'. Furthermore, OCT data of MS patients should be interpreted with caution.

  18. Fascitis plantar: caso clinico

    National Research Council Canada - National Science Library

    Mateos Simon, Piedad

    2007-01-01

    .... El objetivo de este articulo es dar a conocer esta entidad clinica que con tanta frecuencia nos encontramos haciendo hincapie en el diagnostico diferencial de otras entidades que pueden cursar...

  19. Renal cell carcinoma co-existent with other renal disease: clinico-pathological features in pre-dialysis patients and those receiving dialysis or renal transplantation.

    Science.gov (United States)

    Peces, Ramón; Martínez-Ara, Jorge; Miguel, José Luis; Arrieta, Javier; Costero, Olga; Górriz, José Luis; Picazo, Mari-Luz; Fresno, Manuel

    2004-11-01

    Patients on chronic dialysis are prone to developing acquired cystic kidney disease (ACKD), which may lead to the development of renal cell carcinoma (RCC). The risk factors for the development of RCC so far have not been determined in pre-dialysis patients with co-existent renal disease. The aim of this study was to evaluate the clinico-pathological features of RCC in pre-dialysis patients with associated renal diseases or in those undergoing chronic dialysis and renal transplantation. We studied 32 kidneys from 31 patients with RCC and associated renal diseases. Of those, 18 kidneys were from 17 patients not on renal replacement therapy (RRT) when diagnosed with RCC; 14 patients received dialysis or dialysis followed by renal transplantation. Several clinico-pathological features were analysed and compared between the two groups. Overall, there was a preponderance of males (75%); nephrosclerosis was the predominant co-existent disease (31%). The median intervals from renal disease to RCC in the dialysis and transplanted groups were significantly longer than in the pre-dialysis group (15.8+/-1.1 vs 2.4+/-0.7 years, P<0.0001). In contrast to pre-dialysis RCC, the dialysis and transplant RCC groups had greater frequency of ACKD (100 vs 28%, P<0.0001), papillary type RCC (43 vs 11%, P<0.05) and multifocal tumours (43 vs 5%, P<0.05). At the end of the study, 71% of dialysis and transplanted patients and 72% of pre-dialysis patients were alive. ACKD develops in dialysis patients, as it does in those with renal disease prior to RRT. The duration of renal disease, rather than the dialysis procedure itself, appears to be the main determinant of ACKD and RCC. The RCC occurring in patients with ACKD and prolonged RRT is more frequently of the papillary type and multifocal than the RCC occurring in patients with no or few acquired cysts and a short history of renal disease. Long-term outcomes did not differ between the two groups.

  20. The Clinico-pathological Features of Malignant Breast Lymphoma%乳腺恶性淋巴瘤临床病理分析

    Institute of Scientific and Technical Information of China (English)

    刘雪娟

    2011-01-01

    目的 探讨乳腺恶性淋巴瘤的临床病理特征、治疗方式及其与预后关系.方法 1980年1月-2007年12月对收治的21例乳腺恶性淋巴瘤患者的临床病理特点、诊断和治疗方法 进行同顾性分析.结果 21例乳腺恶性淋巴瘤患者均为女性,中位年龄47岁;其中原发性乳腺恶性淋巴瘤18例,继发性恶性淋巴瘤3例.原发件乳腺恶性淋巴瘤均为非霍奇金淋巴瘤,B细胞来源为主,大多为术后诊断,治疗均采用手术+化学疗法.结论 乳腺恶性淋巴瘤治疗应强调手术,化学疗法和放射治疗的综合治疗.%Objective To study the clinico-pathological features and treatment modality of malignant breast lymphoma, and their relationships with the prognosis of the disease. Methods The clinico-pathological features,diagnosis and treatment methods of 21 cases of malignant breast lymphoma diagnosed between January 1980 and December 2007 were analyzed retrospectively and related domestic and overseas literature was reviewed. Results Among the 21 female patients, 18 had primary breast lymphoma (PBL), 3 had secondary breast lymphoma. All cases of PBL were non-Hodgkins lymphoma with mainly B cells as the origin. The median age of the patients was 46. 5 years old. Most of the cases were diagnosed postoperatively and all patients were treated by operation combined with chemotherapy. Related literature reviewing showed that clinical staging and treatment modality were important factors of prognosis. Conclusion In treating malignant breast lymphoma, operation and chemoradiotherapy should be combined together to get a better result.

  1. [Gelastic seizures as the presenting symptom of infarction of the cingulate gyrus].

    Science.gov (United States)

    Egea-Lucas, I; Martinez-Mondejar, E; Piqueres-Vidal, C F; Frutos-Alegria, M T

    2015-09-01

    Introduccion. Las crisis gelasticas son crisis epilepticas poco frecuentes en las que la risa inapropiada es la manifestacion principal. Su etiologia es diversa. No hemos encontrado en la bibliografia ningun caso de risa patologica claramente epileptica relacionada con ictus, aunque hay multiples descripciones de risa patologica no epileptica como sintoma prodromico en pacientes con ictus (fou rire prodromique). Presentamos un caso de infarto del giro cingulado que curso con crisis gelasticas al inicio y durante la evolucion del proceso clinico. Caso clinico. Mujer de 81 años, que bruscamente presento episodios de dificultad para la expresion verbal con desconexion del medio, acompañados de accesos de risa inmotivada e incontrolable de duracion inferior a cinco minutos. Tras los episodios, tenia bajo nivel de consciencia. Coincidiendo con alguno de ellos, se observaron tambien movimientos involuntarios de los miembros superiores. La resonancia desvelo la existencia de una lesion isquemica aguda del territorio del giro cingulado izquierdo y el electroencefalograma puso de manifiesto la existencia de actividad epileptogena frontal y temporal anterior izquierda. Conclusiones. El perfil clinico, los resultados de las exploraciones complementarias y la respuesta al tratamiento antiepileptico permiten afirmar que los episodios descritos en esta paciente corresponden a crisis gelasticas relacionadas con una lesion isquemica aguda del giro cingulado izquierdo.

  2. Clinico-epidemiological profile of fever of unknown origin in an Egyptian setting: A hospital-based study (2009-2010).

    Science.gov (United States)

    Kabapy, Ahmed F; Kotkat, Amira M; Shatat, Hanan Zakaria; Abd El Wahab, Ekram W

    2016-01-31

    Fever of unknown origin (FUO) is one of the most challenging diagnostic dilemmas in the field of infectious diseases and tropical medicine. Clinicians should use the frequency distribution of disorders causing FUO to guide their diagnostic approach in patients with prolonged, unexplained fevers meeting the definition of FUO. The present study was undertaken to examine the etiologies, clinico-epidemiologic profile, and prognosis of classical FUO in patients reporting to the Alexandria Fever Hospital in Egypt. Records of 979 patients admitted to the fever hospital (from January 2009 to January 2010) and diagnosed as having FUO were examined carefully. FUO was defined as three outpatient visits or three days in the hospital without elucidation of cause of fever. A total of 979 cases (57.0% males and 43.0% females), with ages ranging from 0.2 to 90 years, were investigated. The mean duration of fever before hospitalization was 31 ± 10 days. The etiology of FUO was delineated in 97% of cases, and only 3% remained undiagnosed. Diagnoses were grouped into five major categories. Infectious causes of FUO were strongly associated with better outcome (73.7% improved). Smoking, contact with animals or birds, drug addiction, and HIV seropositivity were important risk factors associated with infections. Infections are the most common cause of FUO, followed by collagen vascular diseases, in our region. A three-step diagnostic work-up approach is recommended to be applied in Egypt in order to improve the quality of medical service provided to FUO patients.

  3. The clinico-pathological conference, based upon Giovanni Battista Morgagni's legacy, remains of fundamental importance even in the era of the vanishing autopsy.

    Science.gov (United States)

    Zampieri, Fabio; Rizzo, Stefania; Thiene, Gaetano; Basso, Cristina

    2015-09-01

    Walter Cannon and Richard Cabot inaugurated the clinico-pathological conference (CPC) at Harvard Medical School at the beginning of the twentieth century, but this approach to anatomo-clinical correlation was first introduced by Giovanni Battista Morgagni at the University of Padua in the eighteenth century. The CPC consists of the presentation of a clinical case, in which past and recent medical histories of the patient, with all relevant information about laboratory tests including biopsy results, therapy and, eventually in a fatal case, the autopsy, are discussed. This is done for an audience of trainees and all physicians involved in the care for the patient. The CPC is still in use in many academic hospitals, as a teaching tool not only for undergraduate and graduate medical trainees, but also for postgraduate continuous medical education, in spite of the progressively declining autopsy rate. CPCs represent the ideal occasion for fruitful discussion between the two "souls" of medicine, i.e., the clinical, with its focus on the patient, and the pathological, with its focus on understanding disease. To discontinue using them would be equal to denying that modern medicine originated in Morgagni's method.

  4. An inter-correlative study on clinico-pathological profile and different predisposing factors of oral leukoplakia among the ethnics of Darjeeling, India

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    Krishnendu Mondal

    2017-01-01

    Full Text Available Context: Idiopathic leukoplakia is the most common potentially malignant disorder of oral cavity. Owing to the year-wide cold environment in Darjeeling, here the indigenous ethnic people practice a distinct addiction pattern that strongly predisposes them to oral leukoplakia. Aims: The purpose of the present study was to assess the clinico-pathological profile and various predisposing factors involved in oral leukoplakia, and to correlate its exfoliative cytological appearances with the histopathological diagnoses. Materials and Methods: A total of 53 patients were clinically diagnosed with oral leukoplakia during the study period. All information − clinical data pertaining to the patient and the patch, their personal history including addiction and diet, and the cyto-histopathological features of the lesion − was evaluated and methodically compared with each other using the statistical software, Statistical Package for the Social Sciences version 16.0. Results: The female-dominated cohort was chiefly affected with thin leukoplakia (67.9% involving their buccal mucosa (66.1%. Smokeless tobacco (49.1% was the most popular addiction. Alcoholism and smoking, increasing daily frequency of tobacco misuse, and verrucous and granular leukoplakias were significantly associated with dysplastic transformation (P < 0.05. Out of 16 (30.2% dysplastic lesions, exfoliative cytology correctly diagnosed only six (11.3% cases with a sensitivity of 37.5% only. Conclusion: Verrucous and granular variants are the most detrimental forms of oral leukoplakia. Dysplastic transformation frequently occurs in people addicted to smoking and alcoholism, and verrucous and granular leukoplakia. Lastly, exfoliative cytology poorly predicts the dysplastic evolution within a leukoplakic patch.

  5. Small Bowel Carcinomas in Coeliac or Crohn's Disease: Clinico-pathological, Molecular, and Prognostic Features. A Study From the Small Bowel Cancer Italian Consortium.

    Science.gov (United States)

    Vanoli, Alessandro; Di Sabatino, Antonio; Furlan, Daniela; Klersy, Catherine; Grillo, Federica; Fiocca, Roberto; Mescoli, Claudia; Rugge, Massimo; Nesi, Gabriella; Fociani, Paolo; Sampietro, Gianluca; Ardizzone, Sandro; Luinetti, Ombretta; Calabrò, Antonio; Tonelli, Francesco; Volta, Umberto; Santini, Donatella; Caio, Giacomo; Giuffrida, Paolo; Elli, Luca; Ferrero, Stefano; Latella, Giovanni; Ciardi, Antonio; Caronna, Roberto; Solina, Gaspare; Rizzo, Aroldo; Ciacci, Carolina; D'Armiento, Francesco P; Salemme, Marianna; Villanacci, Vincenzo; Cannizzaro, Renato; Canzonieri, Vincenzo; Reggiani Bonetti, Luca; Biancone, Livia; Monteleone, Giovanni; Orlandi, Augusto; Santeusanio, Giuseppe; Macciomei, Maria C; D'Incà, Renata; Perfetti, Vittorio; Sandri, Giancarlo; Silano, Marco; Florena, Ada M; Giannone, Antonino G; Papi, Claudio; Coppola, Luigi; Usai, Paolo; Maccioni, Antonio; Astegiano, Marco; Migliora, Paola; Manca, Rachele; Martino, Michele; Trapani, Davide; Cerutti, Roberta; Alberizzi, Paola; Riboni, Roberta; Sessa, Fausto; Paulli, Marco; Solcia, Enrico; Corazza, Gino R

    2017-08-01

    An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's disease [CrD]. We explored clinico-pathological, molecular, and prognostic features of CD-associated SBC [CD-SBC] and CrD-associated SBC [CrD-SBC] in comparison with sporadic SBC [spo-SBC]. A total of 76 patients undergoing surgical resection for non-familial SBC [26 CD-SBC, 25 CrD-SBC, 25 spo-SBC] were retrospectively enrolled to investigate patients' survival and histological and molecular features including microsatellite instability [MSI] and KRAS/NRAS, BRAF, PIK3CA, TP53, HER2 gene alterations. CD-SBC showed a significantly better sex-, age-, and stage-adjusted overall and cancer-specific survival than CrD-SBC, whereas no significant difference was found between spo-SBC and either CD-SBC or CrD-SBC. CD-SBC exhibited a significantly higher rate of MSI and median tumour-infiltrating lymphocytes [TIL] than CrD-SBC and spo-SBC. Among the whole SBC series, both MSI─which was the result of MLH1 promoter methylation in all but one cases─and high TIL density were associated with improved survival at univariable and stage-inclusive multivariable analysis. However, only TILs retained prognostic power when clinical subgroups were added to the multivariable model. KRAS mutation and HER2 amplification were detected in 30% and 7% of cases, respectively, without prognostic implications. In comparison with CrD-SBC, CD-SBC patients harbour MSI and high TILs more frequently and show better outcome. This seems mainly due to their higher TIL density, which at multivariable analysis showed an independent prognostic value. MSI/TIL status, KRAS mutations and HER2 amplification might help in stratifying patients for targeted anti-cancer therapy.

  6. Relationship between serum HER2 extracellular domain levels,tissue HER2 expression,and clinico-pathological parameters in early stage breast cancer

    Institute of Scientific and Technical Information of China (English)

    MA Li; YANG Hong-ying; HAN Xiao-hong; LI Jia; WANG Fang; ZHANG Chun-ling; YAO Jia-rui; SHI Yuan-kai

    2012-01-01

    Background Measurement of human epidermal growth factor receptor 2(HER2)protein in the serum of metastatic breast cancer patients has previously been reported,but there are no consistent data to support the clinical utility of serum HER2 extracellufar domain for patients with early stage breast cancer.We aimed to evaluate the correlation between serum extracellular domain levels and tissue HER2 expression,and analyzed their relationship with clinico-pathological parameters in patients with early stage disease.Methods A prospective study was conducted on 232 breast cancer patients with stage Ⅰ-Ⅲ?prior to treatment.Preoperative serum samples were measured by enzyme-linked immunosorbent assay.Tissue HER2 status was analyzed by immunohistochemistry and fluorescence in situ hybridization assays.Results The median serum extracellular domain concentration was 6.8 ng/ml.The best diagnostic cut-off value was 7.4 ng/ml,with 62.9% sensitivity and 85.3% specificity.High serum extracellular domain levels were reported in 89 patients(38.3%),and HER2-positive expression was observed in 77 patients(33.2%).Multivariate analysis showed that elevated serum extracellular domain correlated with postmenopausal status(P<0.001),high histological grade(P<0.001),negativity of both estrogen(P=0.012)and progesterone receptors(P<0.001),and high levels of carcinoembryonic antigen 153(P=0.048).Conclusions We recommend that 7.4 ng/ml should be used as the cut-off value when evaluating serum extracellular domain levels in early stage of breast cancer.Patients with high serum extracellular domain levels have a certain clinicopathological characteristics,may provide a basis for clinical practice.

  7. Cerebellar liponeurocytoma: a newly recognized clinico-pathological entity Liponeurocitoma cerebelar: uma nova entidade clínico-patológica

    Directory of Open Access Journals (Sweden)

    Nádia Montagna

    2002-09-01

    Full Text Available The term "cerebellar liponeurocytoma", recently adopted by the World Health Organization Working Group (WHO, replaced many other different terms used up to now to give name to this rare tumor. To our knowledge, less than 20 cases have been related up to now under different names like as "lipomatous medulloblastoma, lipidized medulloblastoma, neurolipocytoma, medullocytoma and lipomatous glioneurocytoma". The new nomenclature eliminates the word "medulloblastoma", reinforces its benign caracter, and includes it in the category of glioneuronal tumors. We describe an adictional case of this distinct clinico-pathological entity removed from the right cerebellar hemisphere of a 53-year-old woman. With the present case report, we hope to contribute to the knowledge on the diagnostic and prognostic implications derived from the finding of mature adipose-like tissue within a medulloblastomatous tumour.O termo "liponeurocitoma cerebelar" recentemente adotado pela Organização Mundial de Saúde (Classificação de Tumores Cerebrais - versão 2000, surgiu em substituição a vários outros utilizados até então, para denominar esta rara neoplasia. De nosso conhecimento há na literatura menos de 20 casos relatados sob termos diferentes tais como "meduloblastoma lipomatoso, meduloblastoma lipidizado, neurolipocitoma, medulocitoma e glioneurocitoma lipomatoso". A nova nomenclatura elimina a palavra "meduloblastoma", enfatiza seu caráter benigno e o coloca na categoria dos tumores glioneuronais. Descrevemos mais um caso desta rara entidade clínico-patológica, ressecada do hemisfério cerebelar direito em uma mulher de 53 anos. Com este caso esperamos contribuir para o melhor conhecimento sobre o diagnóstico, prognóstico e possibilidades terapêuticas advindas da presença de tecido adiposo em tumor meduloblastomatoso de adultos.

  8. Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature.

    Science.gov (United States)

    La Rosa, Stefano; Furlan, Daniela; Franzi, Francesca; Battaglia, Paolo; Frattini, Milo; Zanellato, Elena; Marando, Alessandro; Sahnane, Nora; Turri-Zanoni, Mario; Castelnuovo, Paolo; Capella, Carlo

    2013-03-01

    Sinonasal intestinal-type adenocarcinomas (ITACs) are rare neoplasms histologically resembling intestinal adenocarcinomas. Although a neuroendocrine differentiation in ITACs has been described, true mixed exocrine-neuroendocrine carcinomas, neoplasms in which each component represents at least 30 % of the lesion, are extremely rare and their molecular alterations are largely unknown. We describe herein the clinico-pathologic features, the methylation profile, chromosomal gains and losses, and mutation analysis of KRAS, BRAF and p53 in a nasal mixed exocrine-neuroendocrine carcinoma resected in a 79-year-old man. The tumor was composed of an ITAC and a poorly differentiated neuroendocrine carcinoma. Both exocrine and neuroendocrine components were CK8, CK20, CDX2 and p53 positive, and CK7 and TTF1 negative. The neuroendocrine component also showed immunoreactivity for chromogranin A, synaptophysin, serotonin and glicentin. Gains and losses were found at following chromosome regions: 17p13 (TP53), 14q24 (MLH3), 19q13 (KLK3), 5q21 (APC), 7q21 (CDK6), 9q34 (DAPK1), 12p13 (TNFRSF 1A, CDKN1B), 13q12 (BRCA2), 17p13.3 (HIC1), 18q21 (BCL2), and 22q12 (TIMP3). Aberrant methylation was detected only in the neuroendocrine component and involved APC and DAPK1 genes. No mutation of KRAS (exons 2-4), BRAF (exon 15), and p53 (exons 4-10) was found in both components. The results suggest a monoclonal origin of the tumor from a pluripotent cell undergoing a biphenotypic differentiation and that the neuroendocrine differentiation may be from an exocrine to an endocrine pathway. We have also reviewed the literature on sinonasal mixed exocrine-neuroendocrine carcinomas to give to the reader a comprehensive overview of these very rare tumor types.

  9. Clinico-radiological profile and outcome of dengue patients with central nervous system manifestations: A case series in an Eastern India tertiary care hospital

    Directory of Open Access Journals (Sweden)

    Souren Pal

    2016-01-01

    Full Text Available Background and Objective: Dengue, an acute viral disease, transmitted by Aedes mosquitoes, has a variable clinical spectrum ranging from asymptomatic infection to life-threatening dengue hemorrhagic fever and dengue shock syndrome. However, neurological complications, in general, are unusual but have been observed more frequently in the recent past, and some studies highlighted varied neurological complications during the course of illness. Although dengue is classically considered a nonneurotropic virus, there is increasing evidence for dengue viral neurotropism. In this study, we have evaluated clinico-radiological profile and outcome of nine serologically confirmed dengue patients having varied manifestations of central nervous system (CNS involvement. Materials and Methods: All the consecutive patients presented with neurological complications with positive serology for dengue infection (IgM positivity in Department of Medicine, in a tertiary care hospital in Eastern India from August 2013 to October 2014 were included in the study. These patients were subjected to a detailed clinical evaluation, laboratory assessment including complete hemogram, coagulation profile, liver function test, serum electrolytes, and routine CSF (Cerebrospinal Fluid study with the exclusion of other common neuroinvasive pathogens. Results: Out of 9 patients with neurological complications associated with confirmed dengue infection, 2 (22% patients had dengue encephalopathy, 5 (56% patients have dengue encephalitis, 1 (11% patient had dengue meningitis, and 1 (11% patient had postdengue immune-mediated CNS involvement. Conclusion: This case series reaffirms the occurrence of varied CNS manifestations in dengue virus infection and underlines the importance of inclusion of dengue in the differential diagnosis of acute encephalitis syndrome.

  10. Surgical treatment of lateral clavicle fractures associated with complete coracoclavicular ligament disruption: Clinico-radiological outcomes of acromioclavicular joint sparing and spanning implants

    Science.gov (United States)

    Bhatia, Deepak N.; Page, Richard S.

    2012-01-01

    Purpose: Distal clavicle fracture associated with complete coracoclavicular ligament disruption represents an unstable injury, and osteosynthesis is recommended. This study was performed (1) to retrospectively analyse the clinico-radiological outcomes of two internal fixation techniques, and (2) to identify and analyse radiographic fracture patterns of fracture that are associated with this injury. Materials and Methods: A total of 15 patients underwent osteosynthesis with either (1) acromioclavicular joint-spanning implants (Group 1, Hook plate device, n = 10) or (2) joint-sparing implants (Group 2, distal radius plate, n = 5); these were reviewed at a mean period of 26.1 months (12 to 40 months). Clinical outcomes were measured using Constant Score (CS), Simple Shoulder Test (SST), and Walch ACJ score (WS). Radiographs and ultrasonography were used to assess the glenohumeral and acromioclavicular joints, and the subacromial space. Preoperative radiographs were analyzed for assessment of fracture lines to identify radiographic patterns. Statistical analysis of the data was performed to determine any significant differences between the two groups. Results: The overall clinical outcome was satisfactory (CS 80.8, SST 11.3, WS 17.6) and a high union rate (93.3%) was observed. Radiographic complications (acromioclavicular degeneration and subluxation, hook migration, abnormal ossification) did not negatively influence the final clinical outcomes. Four distinct radiographic fracture patterns were observed. A statistically significant difference ( P < 0.05) was observed in the reoperation rates between the two groups. Conclusions: Internal fixation of this fracture pattern is associated with a high union rate and favorable clinical outcomes with both techniques. A combination of distal radius plate and ligament reconstruction device resulted in stable fixation and significantly lower reoperation rates, and should be used when fracture geometry permits (Types 1 and 2

  11. Correlation of JAK2V617F mutational status in primary myelofibrosis with clinico-hematologic characteristics and international prognostic scoring system scoring: A single center experience

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    Neha Singh

    2015-01-01

    Full Text Available Introduction: Somatic mutation in the exon 14 of Janus Kinase 2 gene is an established diagnostic marker in bcr-abl negative myeloproliferative neoplasms, especially primary idiopathic myelofibrosis (PIMF. Aim: Our primary aim was to find out the correlation between the JAK2V617F mutational status and the clinico-hematologic characteristics, as well as the international prognostic scoring system (IPSS scoring of patients with PIMF. Materials and Methods: Clinical and hematologic features were reviewed for 68 patients with primary idiopathic myelofibrosis (PIMF. JAK2V617F mutation status was analyzed by amplification refractory mutation screening-polymerase chain reaction. The patients were further stratified into low, intermediate-1, intermediate-2 and high-risk groups on the basis of IPSS scoring. Results: The JAK2V617F mutation was detected in 58.8% patients. Univariate analysis of variables at presentation identified that JAK2V617F negative patients were significantly associated with more severe anemia (P = 0.045, younger age (P = 0.008, higher transfusion requirement (P = 0.017, and thrombocytopenia (P = 0.015. Patients who were homozygous for JAK2V617F mutation were associated with thrombocytosis (P = 0.014 and also had higher median total leucocyte count (P = 0.20 than the other groups. No significant correlation was detected between JAK2V617F mutational status and the presence of constitutional symptoms, spleen size, grade of bone marrow fibrosis or prognostic risk stratification of the PIMF patients. Conclusion: The variations in the prognostic implication of PIMF patients with mutation status as stated by various publications worldwide, reinstates the need for larger prospective studies using standardized JAK2V617F quantification methods as well as estimation of other newer molecular markers to develop deeper insight into various molecular alterations involving PIMF patients in India as well as worldwide.

  12. Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature

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    Lydiatt William M

    2008-11-01

    Full Text Available Abstract Background Germ-cell tumors (GCT are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties. Methods We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm. We correlate their presenting clinico-pathological features and compare histologic and cytogenetic features in an attempt to elucidate their pathogenesis and biologic potentials. Results and discussion Cytogenetic analysis revealed chromosomal abnormalities only in the case of SNTCS that showed trisomy 12 and 1p deletion. Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm. The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential. Conclusion The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes. Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.

  13. Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Cass, Jamaica D. [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Varma, Sonal [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Day, Andrew G. [Kingston General Hospital, Kingston K7L 2V7 (Canada); Sangrar, Waheed [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Rajput, Ashish B. [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Raptis, Leda H.; Squire, Jeremy [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Madarnas, Yolanda [Department of Oncology, Queen’s University, Kingston K7L 3N6 (Canada); SenGupta, Sandip K. [Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada); Elliott, Bruce E., E-mail: elliottb@queensu.ca [Division of Cancer Biology and Genetics, Cancer Research Institute, Queen’s University, Kingston K7L 3N6 (Canada); Department of Pathology and Molecular Medicine, Queen’s University, Kingston K7L 3N6 (Canada)

    2012-07-18

    There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a tissue microarray (TMA) of 63 human breast cancer cases, and correlates these markers with clinico-pathological data. TMA slides were scanned into an Ariol Imaging System, and histologic (H) scores (% positive tumor area x staining intensity 0–3) were calculated using trained algorithms. H scores for all five biomarkers concurred with pathologists’ scores, based on Pearson correlation coefficients (0.80–0.90) for continuous data and Kappa statistics (0.55–0.92) for positive vs. negative stain. Using continuous data, significant association of pERK expression with absence of LVI (p = 0.005) and lymph node negativity (p = 0.002) was observed. p53 over-expression, characteristic of dysfunctional p53 in cancer, and Ki67 were associated with high grade (p = 0.032 and 0.0007, respectively). Cyclin D1 correlated inversely with ER/PR/HER2-ve (triple negative) tumors (p = 0.0002). Thus automated quantitation of immunostaining concurs with pathologists’ scoring, and provides meaningful associations with clinico-pathological data.

  14. Broca's aphemia: an illustrated account of its clinico-anatomic validity Afemia de Broca: um relato ilustrado sobre sua validade anátomo-clínica

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    Ricardo de Oliveira-Souza

    2007-12-01

    Full Text Available OBJECTIVE: To present the case of a 54-year-old man with loss of speech, but with preservation of voluntary facio-lingual motility, language and other cognitive abilities (Broca's aphemia. METHOD: Observation of patient oral communicative abilities and general behavior, neuropsychological assessment and cranial computed tomography. RESULTS: Computed tomography showed a hyperdense lesion in the subcortex of the left precentral gyrus corresponding to Brodmann's area 6 and 44. Neuropsychological assessment confirmed that the major cognitive domains were intact. CONCLUSION: Our patient reiterates the validity of Broca's aphemia as a clinico-anatomic entity allowing us to portray it for the first time in pictures. From a neurobehavioral perspective, aphemia is related to apraxia rather than to aphasia, a fact that may have hampered the full grasp of its far-reaching implications for neurology and aphasiology.OBJETIVO: Apresentar o caso de um paciente de 54 anos de idade com perda da fala, mas preservação da linguagem, das demais capacidades cognitivas, e da motilidade fácio-lingual voluntária (afemia de Broca. MÉTODO: Observação da capacidade de comunicação oral e do comportamento geral, exame neuropsicológico e tomografia computadorizada do crânio. RESULTADOS: A tomografia computadorizada revelou lesão hiperdensa no subcórtex do giro precentral esquerdo correspondendo às áreas 6 e 44 de Brodmann. O exame neuropsicológico confirmou que os principais domínios cognitivos se encontravam intactos. CONCLUSÃO: Nosso paciente reiterou a validade da afemia de Broca como entidade anátomo-clínico permitindo documentá-la em fotos pela primeira vez. Da perspectiva neurocomportamental, a afemia está vinculada às apraxias e não às afasias, o que pode ter prejudicado a apreensão plena do seu profundo significado para a neurologia e para a afasiologia.

  15. Recent outbreak of cutaneous anthrax in Bangladesh: clinico-demographic profile and treatment outcome of cases attended at Rajshahi Medical College Hospital

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    Siddiqui Muhammad

    2012-08-01

    Full Text Available Abstract Background Human cutaneous anthrax results from skin exposure to B. anthracis, primarily due to occupational exposure. Bangladesh has experienced a number of outbreaks of cutaneous anthrax in recent years. The last episode occurred from April to August, 2011 and created mass havoc due to its dreadful clinical outcome and socio-cultural consequences. We report here the clinico-demographic profile and treatment outcome of 15 cutaneous anthrax cases attended at the Dermatology Outpatient Department of Rajshahi Medical College Hospital, Bangladesh between April and August, 2011 with an aim to create awareness for early case detection and management. Findings Anthrax was suspected primarily based on cutaneous manifestations of typical non-tender ulcer with black eschar, with or without oedema, and a history of butchering, or dressing/washing of cattle/goat or their meat. Diagnosis was established by demonstration of large gram-positive rods, typically resembling B. anthracis under light microscope where possible and also by ascertaining therapeutic success. The mean age of cases was 21.4 years (ranging from 3 to 46 years, 7 (46.7% being males and 8 (53.3% females. The majority of cases were from lower middle socioeconomic status. Types of exposures included butchering (20%, contact with raw meat (46.7%, and live animals (33.3%. Malignant pustule was present in upper extremity, both extremities, face, and trunk at frequencies of 11 (73.3%, 2 (13.3%, 1 (6.7% and 1 (6.7% respectively. Eight (53.3% patients presented with fever, 7 (46.7% had localized oedema and 5 (33.3% had regional lymphadenopathy. Anthrax was confirmed in 13 (86.7% cases by demonstration of gram-positive rods. All cases were cured with 2 months oral ciprofloxacin combined with flucoxacillin for 2 weeks. Conclusions We present the findings from this series of cases to reinforce the criteria for clinical diagnosis and to urge prompt therapeutic measures to treat

  16. STUDY OF CLINICO- EPIDEMIOLOGICAL PROFILE OF PATIENTS ADMITTED WITH INFANTILE TREMOR SYNDROME (ITS AND STATUS OF TRACE ELEMENTS (ZINC, COPPER DEFICIENCY IN THEM

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    Mohan Makwana

    2017-03-01

    Full Text Available BACKGROUND Under nutrition is one of the major problems in the field of Paediatrics. The greatest risk of malnutrition is in the first two years of life. The effects of this early damage on health, brain development, intelligence, educability and productivity are potentially reversible. The current study was an attempt to find out the clinico epidemiological profile, evaluate them for trace elements deficiency and most appropriate management options in those who are admitted with infantile tremor syndrome. MATERIALS AND METHODS The current study was a hospital based cross sectional study that was conducted in the Department of Paediatrics, Dr. S. N. Medical College Jodhpur. Duration of study was One Year. Any child up to the age of three years of age admitted in the paediatric wards with typical features of infantile tremor syndrome. RESULTS Maximum numbers of patients were found between 6 months to 12 months of age, there was slight male predominance. The majority of infants in our study (85% were exclusively breast fed, 66% of cases were having low serum Copper level. 9% of cases were having low serum zinc level. 8% of cases were having low serum copper level with tremors. CONCLUSION In our study the fact that NTS is mainly seen in children who are exclusively breast feed for a longer period with delayed introduction of weaning foods. The main presenting features remain developmental delay, hyper pigmentation and anemia. Among nutritional factors, deficiency of copper and zinc in children plays a big role in development of disease. Thus to prevent the development of nutritional tremor syndrome stress should be on early timely introduction of weaning foods, especially rich in copper and zinc. What is already known about this Study- low levels of trace elements like copper and zinc may be responsible for typical clinical manifestations in patients of infantile tremor syndrome. Pronged and Exclusive breast feeding further aggravate these features

  17. [Quality control at the Istituto di Anatomia e Istologia patologica at the Università di Bologna].

    Science.gov (United States)

    Alampi, G; Baroni, R; Berti, E; Ceccarelli, C; Dina, R; Eusebi, V; Giangaspero, F; Grigioni, F W; Lecce, S; Losi, L

    1994-04-01

    The growing importance in medical practice of a standardized diagnosis in cyto- and histopathology and the recent recommendations for the adoption of standardized schemes for quality control in anatomic pathology by International Committees stimulated the medical staff of the Institute of Anatomic Pathology of the University of Bologna to adopt a pertinent method. The method used by the Department of Pathology of the Yale University (New Haven, Connecticut, USA) was chosen. A Committee for the quality control was appointed and two kinds of controls were set up: an External Quality Assessment (review of the difficult cases by external experts, slide seminars) and an Internal Quality Assessment performed by the members of the Committee on the diagnostic and laboratory routine of the Institute. Such a survey is periodically monitored during the monthly meetings of the Committee and described in the monthly reports. The present paper illustrates the method adopted and the preliminary results obtained in order to stimulate the discussion of such a critical theme in contemporary Anatomic Pathology at a national level.

  18. 子宫乳头状浆液性癌临床病理分析及治疗探讨%Clinico-pathologic features and treatment of uterine papilla ry serous carcinoma

    Institute of Scientific and Technical Information of China (English)

    李胜泽; 马玲

    2001-01-01

    Objective To study the rational therapy for uteri ne papillary serous carcinoma(UPSC)and analyze its clinico-pathologic features. Methods Sixteen cases of UPSC were treated in our hospital betw een January 1,1983 and June 30,1998.The clinico-pathologic features,treatment m ethods and prognosis were retrospectively analyzed.Results All the patients underwent operation,fourteen of them received radiotherapy and /or postoperative chemotherapy.Deep myometrial invasion occured in 56 .2% of the cas es (9/19).62.5% had extrauterine disease(10/16).The rate of lymph node metastasi s was 62.5%(5/8).Estrogen or progestin receptors were rarely seen. Nine of the s ixteen died during the follow-up period,indicating poor prognosis. Conclusions The clinico-pathologic features of UPSC are differ ent from the common endometrial carcinoma.Rationally individualized treatment c an lengthen survival time.%目的通过对子宫乳头状浆液性癌的临床病理特征的分析,探讨其合理的治疗方法。方法自1983年1月至1998 年6月,我院收治子宫乳头状浆液性癌16例,对其临床病理、治疗及预后进行回顾性研究。结果全部病例采用手术治疗,术后辅助放疗和/或化疗者14例。56.2%的病例肌层浸润深度超过1/2肌层(9/16),62.5%有宫外扩散(10/16),淋巴结转移率6 2.5%(5/8),几乎缺乏雌、孕激素受体。预后差,随访期内9例死亡。结论子宫乳头状浆液性癌有其独特的临床病理特征,与普通的子宫内膜癌明显不同,合理的个体化综合治疗可延长生存期。

  19. Estudo clinico da epilepsia catamenial: tipos clinicos das crises epilepticas

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    Arthur Oscar Schelp

    1983-06-01

    Full Text Available Foram atendidas 431 pacientes epilépticas com idades acima de 10 anos, no período de fevereiro a julho de 1981 no ambulatório de neurologia do H.C.F.M.R.P. Destas, foram selecionadas 119 pacientes com idade de 13 a 45 anos e/ou fluxo menstrual periódico e pelo menos uma crise epiléptica ao mês. As pacientes foram separadas em dois grupos, o primeiro constituído de 36 pacientes com diagnóstico de epilepsia catamenial e o segundo com 83 pacientes que apresentavam epilepsia não catamenial. Determinamos um coeficiente de prevalência de 105,9/1000 para a epilepsia catamenial. Classificamos os tipos clínicos de crises epilépticas ocorridas em pacientes com epilepsia catamenial e comparamos com as ocorridas em pacientes na menacme.

  20. 涎腺腺泡细胞癌的临床病理分析%A Clinico-pathological Study on Acinic Cell Carcinoma of Salivary Glands

    Institute of Scientific and Technical Information of China (English)

    张丽慧; 吴兰雁; 姚甜; 赵业; 郑亚鸽

    2014-01-01

    目的:探讨涎腺腺泡细胞癌(AciCC)的临床病理特征及与生物学行为相关的病理因素。方法:收集1988-2011年,四川大学华西口腔医院的腺泡细胞癌病例68例,进行临床病理学分析和随访调查。结果:平均发病年龄为44.4岁,20岁以下4例(5.9%),男女比例为1∶1.13;就诊平均病程为45.2个月。肿瘤发生于腮腺为57例(83.8%)、腭部为4例(5.9%)、颊部为3例(4.4%)、颌下腺为2例(2.9%)。68例AciCC中,56例获随访信息,随访率为82.4%。复发率为26.5%,颈部淋巴结转移率为8.82%,5年生存率为98.21%。肿瘤间质中有大量淋巴样细胞浸润的患者,复发率较低(P<0.05)。结论:AciCC肿瘤间质中大量淋巴样细胞浸润,是提示患者预后较好的一个病理指标。%Objective:To discuss the clinico-pathological features of acinic cell carcinoma ( AciCC) and its relation with the biological behavior. Methods:68 cases of acinic cell carcinoma were collected from the files of West China Stomatol-ogy Hospital, Sichuan University. A clinicopathological features and followed up data were analyzed. Results: There were 32 males and 36 tamales with a ratio of 1∶1.13. The mean age of the patients was 44.4 years, 4 of 68 patients (5.9%) were under 20 years old at the time of excision of their primary tumor. The average duration of symptoms was 45.2 months. The majority of AciCC cases located in the parotid gland (57 cases, 83.8%), followed by palate gland (4 cases, 5.9%), buccal gland (3 cases, 4.4%) and submandibular gland (2 cases, 2.9%) respectively. Follow-up information was obtained from 56 cases (82.4%). The local recurrence rate was 26.5%, with a rate of metastasis to cervical lymph nodes in 8.82%. The five year survival rate was 98.21%. In histopathological features, cases those with a prominent lymphoid infiltration of the stro-ma had a more favorable prognosis, and with a lower recurrence rate (P<0

  1. Childhood Henoch-Sch(o)nlein Purpura Nephritis and IgA Nephropathy:One Disease Entity?--A Clinico-pathologically Comparative Study

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    in 81.6 % of IgA nephropathy, among them most showed IgA and IgM and/or C3 deposits, moreover overwhelming IgG deposits and linear IgG deposits couldn't be found in IgA nephropathy. Mean 20 months follow-up showed complete remission in 72.5 % of HSPN, but only 19.4 % in IgA nephropathy after 34 months follow-up. Moreover, 64.5 % of IgA nephropathy had consistent hematuria and proteinuria and 16.1% had active nephritides (P<0.05). It was concluded that significant clinico-pathological difference was found between HSPN and IgA nephropathy, which didn't support the one disease entity hypothesis.HSPN and IgA nephropathy are probably two diseases with similar immune abnormalities.

  2. CLINICO - MYCOLOGICAL STUDY OF ONYCHOMYCOSIS

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    Sharath Kumar

    2013-10-01

    Full Text Available ABSTRACT : Onychomycosis is defined as the fungal infection of the nail by any fungus including non - dermatophy tes and yeasts . Tinea unguium is clinically defined as a dermatophytic infection of the nail plate. OBJECTIVES : To assess the prevalence of fungal infections in nail disorders and to find out incidence of dermatophytes , candida and other non - dermatophytic moulds. METHODOLOGY : History of patient was noted. The material was collected from lesions which were inoculated to the media. Slants were incubated and examined. If there was growth of dermatophytes , they were subjected to lactophenol cotton blue staining . RESULTS : Incidence was 100 ( out of 260 nail cases. Male: female ratio was 1.3:1.69% presented with subungual hyperkeratosis. Distal subungual onychomycosis was most common ( 51% , proximal ( 46% and superficial white ( 3%. Predisposing factor - occupation associated with wet work ( 48% . Commonly isolated species were dermatophytes ( 31% in which more common was trichophyton rubrum ( 27% , Non dermatophytes ( 48% , Aspergillus species ( 41% , and candida albicans ( 4% . INTERPRETATION AND CONCLUSION : Finger nai ls were commonly affected . A ssociated diseases were Tinea pedis , Tinea manum , diabetes mellitus and anemia. It is a significant and important disease which can generate physical , psychological and occupational problems.

  3. 胰腺浆液性囊腺瘤临床病理特点分析%Clinico-pathological characteristics of serous cystadenoma of pancreas

    Institute of Scientific and Technical Information of China (English)

    刘娟; 唐白杰; 徐钢; 王晓卿; 李科; 刘翔

    2015-01-01

    Objective To investigate the clinico-pathological features of serous cystadenoma of pancreas (SCAP).Methods Twelve cases of SCAP were collected from Jan .2010 to Jun.2014 at department of pathology of Sichuan Provincial People 's Hospital. The clinical characteristics and pathological features were retrospectively analyzed .Results Of the 12 cases,there were 2 males and 10 females.The age of patients ranged from 36 to 73 years old and with a mean age of 53 years old.Five cases were found on routine medi -cal examinations without clinical symptoms .Seven cases had varying degrees of abdominal pain or abdominal distension .Four cases were in pancreatic head,1 in pancreatic body,3 in pancreatic tail,and 4 in pancreatic body and tail.Six patients were found to be accompa-nied with cystic diseases of liver and /or kidney.Under microscopic examination,the tumors were found to compose of multiple small cysts lined by flattened or cuboidal epithelial cells containing abundant glycogen .Tumor cells were consistent with clear cytoplasm and round or oval shaped nucleus ,and without nuclear mitotic.The stroma of the tumors was found to contain fibrous tissue .By using immu-nohistochemical staining,the tumor cells were positive for CK7,CK19 and EMA in all cases while α-inhibin was positive in varying de-grees in 10 cases.Ki-67 was weak expressed with positive rate from 1%to 2%.All patients were treated with mass resection ,and lived without recurrence during the follow -up periods from 3 to 55 months.Conclusion Serous cystadenoma of pancreas is a rare tumor .The diagnosis and differential diagnosis mainly depends on histopathological and immunohistochemical examinations combined with radiolog -ical examinations.This tumor has a good prognosis after surgical removal .%目的:探讨胰腺浆液性囊腺瘤(serous cystadenoma of the pancreas ,SCAP)的临床病理学特点。方法收集四川省人民医院病理科2010年1月至2014年6月12例诊断为 SCAP

  4. Magnitude and severity of anemia, its clinico-pathological types and the burden of iron deficiency in adolescent boys: Is weekly iron supplementation a step in the right direction

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    Monalisha Sahu

    2014-12-01

    Full Text Available Background: Iron-deficiency anaemia is a major global public health problem affecting all stages of life cycle. Adolescent boys are also vulnerable to it owing to their growth spurt and inadequate dietary intakes. Assessment of anaemia and quantification of the burden of iron-deficiency anemia in them has been less studied. Knowledge of these aspects at the local level may help public health functionaries take appropriate decisions. Objectives: i To assess the magnitude and severity of anaemia in adolescent boys residing in a peri-urban community of Delhi, ii To identify the clinico-pathological type of anemia and among adolescent boys residing in a South Delhi locality iii To estimate the burden of iron deficiency in them. Materials and Methods: A Community-based cross sectional study was conducted in 250 adolescent boys at Mehrauli in South Delhi in 2012. Hemoglobin estimation was done by Hemocue method, severity of anaemia assessed as per WHO criteria. To assess the clinico-pathological type of anaemia peripheral smears were prepared and stained with Wright Giemsa stain for assessing red-cell morphology. Serum ferritin estimation by MAb ELISA was done to confirm Iron deficiency. Statistical analysis: SPSS ver 12 and Epi Info ver 7 softwares were used for data entry and analysis. Mean and SD was calculated for quantitative variables while qualitative variables were compared by percentages. Chi-square test and ANOVA was used for checking statistical significance in observed differences. Results: Pallor was seen in 14.6%. Prevalence of anaemia was 16.4% with proportion of mild, moderate and severe anemia being 66.7%, 31.2% and 2.1% respectively. Mean haemoglobin concentration was 13.03 ±1.18 gm% (min 7.6, max 15.0. Anemia prevalence increased with increase in age (9.6%, 18.4% and 26.0% in early, middle and late adolescence, respectively. Clinico-pathological type of anaemia was microcytic-hypochromic in 50.0%, normocytic-normochromic in 17

  5. 218例40岁以下青年人肺癌临床特征分析%Clinico-pothologic studies on 218 lung cancer patients under 40 years of age

    Institute of Scientific and Technical Information of China (English)

    张颖秋; 蒋鑫; 林建武; 林莉; 庞帅; 王桂芳

    2011-01-01

    Objective To study whether the clinico-pothologic characteristics of young lung cancer patients (≤40 years of age) and compare with those of older lung cancer patients (>40 years of age).Methods Retrospective analysis was carried out to compare the clinico-pathologic features of 218 young patients (young group) with those of 944 older ones (older group). Results Compared with the older group,young group had more female (39% vs 27%, P <0. 001), different constitution of pathological types ( P < 0. 001 ) characterized with more adenocarcinoma (50.9%), more advanced-stage disease (76.0% vs 48.0%, P <0. 001) and less patients underwent surgery ( P <0. 001). Cough was the most common presentation (73.9%),and other symptoms were not common. Combined-modality therapy was not common (20.2%) in the young group. Conclusions Young patients with lung cancer present difference in clinico-pathologic features from the older ones. The younger type of lung cancer should be paid attention to.%目的 探讨≤40岁青年人肺癌的临床及病理特征,并与>40岁的中老年人肺癌进行比较。方法 对218例青年人肺癌(青年组)以及同期的944例中老年人肺癌(中老年组)进行回顾性分析,比较两组临床及病理特征。结果 青年组女性患者比例高(39% vs 27%,P<0.001),以腺癌为主要病理类型(50.9%),病理类型构成与中老年组相比有显著差异(P<0.001)。咳嗽是最常见的症状(73.9%),其他症状的发生率均不高。青年组患者确诊时晚期比例高(76.0% vs 48.0%,P<0.001),接受手术治疗比例显著低于中老年组( P<0.001),接受综合治疗比例也较低(20.2%)。结论 青年人肺癌具有其特殊的临床及病理特征,明显不同于中老年人肺癌,应提高对青年人肺癌的认识。

  6. Clinico -pathologic characteristics and molecular phenotypes of breast cancer in young patients%青年乳腺癌临床病理特征及分子分型分析

    Institute of Scientific and Technical Information of China (English)

    王虎霞; 宋张骏; 朱江; 韩丕华; 杨晓民; 邓智平; 李阳

    2016-01-01

    Objective:To investigate the clinico -pathologic characteristics and molecular phenotypes of breast cancer in young patients.Methods:Data from 64 cases of infiltrating ductal carcinoma in young patients(age≤35 years)who underwent surgery between January 2012 and June 2015 were reviewed.66 cases of infiltrating ductal car-cinoma in middle -aged and elderly patients(age >35 years)during the corresponding period were randomly selected as controls.The clinico -pathologic characteristics and molecular phenotypes were retrospectively analyzed.Results:The young patients of breast cancer significantly different from the middle -aged and elderly patients in terms of tumor size,pathologic stage,lymph node metastasis and the expression of Ki -67(P 0.05).Conclusion:Young patients of breast cancer have larger size,more lated pathologic stage and higher expression of Ki -67 compared with the middle -aged and elderly.Early screening and prompt treatment are necessary for young patients of breast cancer.The mechanisms of the strong invasion and metastasis still need further study.%目的:探讨青年乳腺癌临床病理特征及分子分型情况。方法:收集陕西省肿瘤医院2012年1月至2015年6月经手术切除、病理证实的年龄≤35岁的青年乳腺浸润性导管癌病例64例,随机抽取同期年龄>35岁的中老年乳腺浸润性导管癌66例作为对照,回顾性分析其临床病理特征及分子分型情况。结果:青年乳腺癌与中老年乳腺癌在肿瘤大小、病理分期、淋巴结转移及 Ki -67表达方面差异有统计学意义(P <0.05),二者分子分型的分布差异无统计学意义(P >0.05)。结论:青年乳腺癌肿瘤体积大,病理分期晚,Ki -67表达指数高,应重视其早期筛查与治疗,其高侵袭转移机制有待进一步研究。

  7. 青年乳腺癌临床病理特点分子分型及预后分析%Clinico pathologic characteristics and molecular phenotypes of young breast cancer patients and their clinical significance

    Institute of Scientific and Technical Information of China (English)

    秦颖; 张同先; 张巍; 吕淑华; 牛昀

    2014-01-01

    Objective:To study the clinico-pathologic characteristics, molecular phenotypes, and prognosis of young breast can-cer patients. Methods:Data from 133 low-age (age≤30 years) young breast cancer patients and 117 young (31 years≤age≤35 years) breast cancer patients who underwent surgery between January 2002 and December 2009 were reviewed. Cases of the middle and old-age elderly (age>35 years) breast cancer patients during the corresponding period were randomly selected as matched controls. The clinico-pathologic characteristics, molecular phenotypes, and prognosis were retrospectively analyzed. Results:The low-age young and young breast cancer patients significantly differed from the elderly patients in terms of tumor size, lymph node metastasis, histological grading, molecular phenotype, and relapse (P35岁的中老年乳腺癌214例作为对照,回顾性分析其临床病理资料、分子分型及预后情况。结果:低龄青年乳腺癌、31~35岁青年乳腺癌与中老年乳腺癌在肿瘤大小、淋巴结转移、组织学分级、分子分型和肿瘤复发方面差异有统计学意义(P<0.05)。低龄青年乳腺癌更易出现三阴性乳腺癌、复发及远处转移(P<0.001),并且低龄青年乳腺癌与31~35岁青年乳腺癌、中老年乳腺癌相比,有较低的总生存率和无病生存率(P<0.05)。结论:年龄≤35岁青年乳腺癌症状隐匿,预后不佳,与中老年乳腺癌有不同的临床病理特征、分子分型及预后,应重视早期筛查与治疗。

  8. 间质性肺疾病临床表现和影像学及病理诊断中应注意的问题%Some problems for clinico-radiologic-pathologic diagnosis of lung interstitial disease

    Institute of Scientific and Technical Information of China (English)

    易祥华

    2008-01-01

    间质性肺疾病(ILD)对人类的危害与日俱增,但其诊断一直是临床和病理医生感到困惑的问题。目前我国ILD的病理诊断还远不能适应临床的要求,其原因是多方面的。通过近年来的临床实践我们认识到,临床、影像和病理诊断(clinico-radiologic-pathologic diagnosis,CRP诊断)对正确诊断ILD具有十分重要的意义。但在日常的临床诊断过程中,CRP的诊断仍存在诸多问题。为此,笔者就ILD的CRP诊断必要性、临床医生应该注意的问题以及病理科与临床科室的沟通提出一些看法,供临床和病理科医生参考。

  9. 意外胆囊癌的临床病理特点与预后分析%Analysis of the clinico-pathological features and prognosis of incidental gallbladder cancer

    Institute of Scientific and Technical Information of China (English)

    欧阳杰; 汤地; 匡铭; 彭宝岗; 梁力建

    2011-01-01

    Objective To investigate the clinico-pathological feature , surgical treatment and prognosis of incidental gallbladder cancer. Methods The clinico-pathological data and prognosis of 36 patients of incidental gallbladder cancer surgical treated in our hospital from January 2001 to December 2009 were retrospectively analyzed. Results According to the AJCC stage system for gallbladder cancer , there were 2 cases of stage 0,9,11 cases of stage I A and I B ,5 cases of stage IIA, 1 case of stage IIB,2 cases of stage IH and 6 cases of stage IV entered in this research. 8 cases underwent open cholecystectomy and 10 underwent laparoscopic cholecystectomy. 16 cases underwent open cholecystectomy combined with partial hepatectomy and regional lymph node dissection . 2 cases underwent only exploratory surgery because of the late stage tumor. There were no perioperative deaths in this group of patients . The overall 1,3 and 5 year survival rates were 70. 0% ,60. 0% and 26. 7% respectively. Survival analysis showed that the thickness of gallbladder wall, regional LN metastasis, AJCC stage and surgery methods were the statistically significant factors that effecting the overall survival of patients . Conclusions Incidental gallbladder carcinoma can have good prognosis if treated in early stage. Regular following up for patients with high risk factors of gallbladder cancer, necessary radiological and ultrasound examinations and serological tests for tumor markers , timely surgery and intraoperative frozen section examination may be effective ways to increase the preoperative diagnosis rate and improve the prognosis of gallbladder carcinoma .%目的 探讨意外胆囊癌的临床病理特点、治疗与预后.方法 回顾性分析我院2001年1月至2009年12月手术治疗的意外胆囊癌共36例的临床资料、治疗方式以及预后.结果 本组AJCC分期:0期2例,Ⅰ A期9例,Ⅰ B期11例,ⅡA期5例,ⅡB期1例,Ⅲ期2例,Ⅳ期6例.治疗方式包

  10. Radiological Manifestations of Mesoblastic Nephroma; Manifestaciones radiologicas del nefroma mesoblastico

    Energy Technology Data Exchange (ETDEWEB)

    Muro, D.; Sanguesa, C.; Brugger, S.; Moreno, A.; Castell, V. [Hospital Infantil Universitario La Fe. Valencia (Spain)

    2004-07-01

    To analyze the radiological and clinical findings of mesoblastic nephroma (MN) in paediatric age. Retrospective study of 9 patients with histological MN diagnoses. The tumor was analyzed by means of ultrasound scan and abdominal CT in order to determine its location, size and internal structure. Regarding the latter, determinations were made concerning possible presence of subcapsular hematoma, ring sign characteristics, tumor boundaries, infiltration of adjacent tissues and presence of metastasis. Clinical patient information considered at the outset was that concerning treatment and evolution, patient age, abdominal palpation, hypertension, hypercalcaemia, hematuria and anemia. 76% of the tumors were located in the central portion of the kidney. Average tumor volume was 70 cm''3 77% appeared to be solid while 55% of tumor peripheries presented echogenic rings. 76% showed subcapsular hematoma. One patient presented extension into adjacent tissues. tumor boundaries were poorly defined in all cases. Average patient age was 15 days, abdominal mass palpation was performed in all cases and hypertension was detected in 33%. Surgical margins were not tumor-free in one patient only. Two patients died from non-tumor related causes. These are renal tumors in infancy whose evolution could involve hypertension. In general, they tend to be solid. Their boundaries are poorly defined. Presence of subcapsular hematoma is common, as well as images depicting concentric rings in the periphery. Contiguous extension is rare. Surgical resection was the only treatment with excellent prognosis. (Author) 24 refs.

  11. Training in radiological protection; Capacitacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Medina G, E., E-mail: medina@ipen.gob.pe [Instituto Peruano de Energia Nuclear, Av. Canada 1470, San Borja, Lima 41 (Peru)

    2014-08-15

    In the Peru, according to the current regulations, people that work with ionizing radiations should have an authorization (individual license), which is granted by the Technical Office of the National Authority that is the technical body of the Instituto Peruano de Energia Nuclear (IPEN) manager of the control of ionizing radiations in the country. The individual license is obtained after the applicant fulfills the requested requirements, as having safety knowledge and radiological protection. Since its founding in 1972, the Centro Superior de Estudios Nucleares (CSEN) of the IPEN has carried out diverse training courses in order to that people can work in a safe way with ionizing radiations in medicine, industry and research, until the year 2013 have been organized 2231 courses that have allowed the training of 26213 people. The courses are organized according to the specific work that is carried out with radiations (medical radio-diagnostic, dental radiology, nuclear medicine, radiotherapy, industrial radiography, nuclear meters, logging while drilling, etc.). In their majority the courses are directed to people that will make use of radiations for first time, but refresher courses are also granted in the topic. The CSEN also carries out the Master degree programs highlighting the Second Professional Specialization in Radiological Protection carried out from the year 2004 with the support of the National University of Engineering. To the present has been carried out 2 programs and there is other being developed. In this work is shown the historical evolution of the radiological protection courses as well as the important thing that they are to work in a safe way in the country. (Author)

  12. Radiological protection in pediatric radiodiagnostic; Proteccion Radiologica en Radiodiagnostico Pediatrico

    Energy Technology Data Exchange (ETDEWEB)

    Espana Lopez, M. L.; Gomez Mardones, G.; Garcia Gastonon; Bermudez Luna, R.; Garcia Esparza, E.; Solis Muniz, I.

    2010-07-01

    Diagnostic x-ray examinations remains the most frequent use of ionizing radiation in medicine, and represent the most significant source of medical exposure. Justification and optimization process are worthy of special considerations for the pediatric patient, in view of their longer life expectancy and the increased risk for stochastic effects. the aim of the present study is to review the state of the art of the radiation protection in pediatric radiology. Proper equipment, periodic quality control, pediatric protocols, experienced operator, experienced operator, dosimetric estimations, superficial shielding and evaluation of image quality are required to achieve patient doses. As low As Reasonably Achievable in pediatric radiology. Technical advances haves increased the number of possibilities to reduce patient doses, but their optimal use implies a deep knowledge of the different technology. Practical dosimetry, dose indicators and dose reference levels are essential elements of patient protection, and must be reviewed for the pediatric patient, especially in higher radiation doses procedures, such CT and interventional examinations. Although the most effective way to reduce the radiation dose is to eliminate the unnecessary referrals, Radiology Department and Medical Physics and Radiological Protection Department, must be involved in the optimizations procedures in order to achieve ALARA patients dose in pediatric radiology reflects the reality in our country. (Author) 37 refs.

  13. Laboratory of environmental radiological surveillance; Laboratorio de vigilancia radiologica ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Mendez G, A.; Marcial M, F.; Giber F, J.; Montiel R, E.; Leon del V, E.; Rivas C, I.; Leon G, M.V.; Lagunas G, E.; Aragon S, R.; Juarez N, A.; Alfaro L, M.M

    1991-12-15

    The department of radiological protection of the ININ requests the collaboration of the Engineering Unit for the elaboration of the work project of the laboratory of environmental radiological surveillance. The emission of radioactive substances to the atmosphere like consequence of the normal operation of the Nuclear Center, constitutes an exhibition source from the man to the radiations that it should be appropriately watched over and controlled to be able to determine the population's potential exhibition that it lives in the area of influence of the installation. (Author)

  14. Radiation protection optimization; Optimizacion de la proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Barea, P. J.

    2009-07-01

    The basic purpose of the optimization of radiation protection in the Cofrentes Nuclear Power Plant is to succeed in keeping the individual doses received by plant workers and the collective dose received by all of them as low as reasonably achievable. Based on this goal, the work is planned so that the individual doses and the number of people exposed to ionizing radiation are kept as low as possible (Program ALARA) in a way compatible with job execution. (Author)

  15. External plans for radiological emergency; Plan de emergencia radiologica externo

    Energy Technology Data Exchange (ETDEWEB)

    Suarez, G.; Vizuet G, J.; Benitez S, J.A. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1999-07-01

    Since 1989, the National Institute of Nuclear Research in Mexico shares in the task of Food and Water Control corresponding to the FT-86 task force of External Plans for Radiological Emergency (PERE), in charge of the Veracruz Health Services. In the PERE preparation stage previous actions are necessary developed for the preparation and updating of this plan and the task organization with the purpose to maintaining standing and operable in any time and circumstance, the capability to response in the face of an emergency. This stage englobes activities which must be realized before to carry out the Plan as they are the specialized training of personnel which participates and the execution of exercises and simulacrums. Until 1998, training and exercises for this task had been realized under diverse possible sceneries but in conditions that simulated the presence of radioactive material. For this reason, it should be emphasized the training realized during the days 6th, 7th, 8th July, 1999, in the emergency planning zone of the Plan, which to carry out using radioactive material. The National Institute of Nuclear Research had in charge of the training. This work describes all the activities for the realization of this training. (Author)

  16. Radiologic evaluation of facial injury; Avaliacao radiologica dos traumatismos faciais

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Ricardo Pires de; Volpato, Richard [Complexo Hospitalar Heliopolis, Sao Paulo, SP (Brazil). Servico de Diagnostico por Imagem]. E-mail: richard_volpato@uol.com.br; Nascimento, Lia Paula [Complexo Hospitalar Heliopolis, Sao Paulo, SP (Brazil)

    2003-03-01

    A detailed radiological investigation of the maxillofacial injuries is essential to achieve good treatment results. The images should identify every lesion and guide the treatment, thus improving esthetic and functional results. With the aim of simplifying the diagnostic task, the face may be seen as a five regions structure that may suffer a regional fracture or combined fractures involving the adjacent regions. These regions represent areas of focus for pre surgical planning and are as follows: nasal, orbital, zygomatic, maxillary, and mandibular. In order to understand the injury mechanisms and their consequences it is useful to know the supporting buttresses, which are divided in five sagittal planes, three horizontal planes and two coronal planes. We reviewed the cases of patients with facial trauma treated at Complexo Hospitalar Heliopolis, Sao Paulo, Brazil. A review of the relevant issues concerning radiological investigation of these injuries is presented. This study allowed standardization and ordering of the radiological investigation in patients with facial trauma. (author)

  17. Lesiones anatomo-patologicas en cuyes intoxicados experimentalmente con Pteridium aquilinum como modelo animal para bovinos con hematuria vesical enzootica bovina

    National Research Council Canada - National Science Library

    Ramos G., Mariella; Chavera C., Alfonso; Tabacchi N., Luis; Huaman U., Hector; Sandoval C., Nieves; Rodriguez G., Jose

    2012-01-01

    ...) intoxicados experimentalmente por via oral con pellets conteniendo Pteridium aquilinum (Pa) por 135 dias. El cuy se empleo como modelo experimental para bovinos con Hematuria Vesical Enzootica Bovina...

  18. Correlacion clinica-patologica de corioamnionitis en pacientes que ingresan al servicio ginecologia en el año 2009 en el Hospital Universitario Clinica San Rafael

    OpenAIRE

    2011-01-01

    Este trabajo tuvo como utilidad básica determinar cuál es la correlación del diagnóstico clínico con los criterios de Gibss y con el Gold estándar que es la patología en las paciente con corioamnionitis para así poder establecer si el diagnostico se realizó en forma adecuada y cuáles son los criterios más relevantes para su diagnóstico. Dicha investigación se realizó de la siguiente manera: 1. Se Identificaron las pacientes que ingresaron al servicio de urgencias...

  19. Controversies on Hodgkin's disease and anaplastic large cell lymphoma. Hematopathology Study Group of the Società Italiana di Anatomia Patologica.

    Science.gov (United States)

    Pileri, S

    1994-01-01

    Just one year ago the Italian Society of Pathology (S.I.A.P.) created a Study Group which included members of the most active Italian hematopathology teams. Prof. Pasquale Calapso was asked to chair the Group and Prof. Stefano Pileri to take care of secretarial duties. The aim of the Group is to spread hematopathologic knowledge among young pathologists and to promote activities that can contribute to updating Italian pathologists on topics of both speculative and diagnostic interest. The first Workshop of the S.I.A.P. Hematopathology Group was held at the Palazzo dei Congressi in Bologna, November 20, 1993. About 150 pathologists from all over Italy took part in the meeting, which consisted of two sections devoted to: a) discussion of the boundaries between Hodgkin's disease and non-Hodgkin's lymphomas, and b) a case seminar illustrating the impact of immunohistochemistry in the diagnosis of bone-marrow biopsy. The first section included 5 presentations and a Round Table chaired by Prof. Luciano Fiore-Donati. Below, the contributors to this section summarize the content of their presentations, which were aimed at answering specific questions the Organizers had put to them.

  20. Infiltration of soft tissue by myeloma after internal fixation of pathologic femoral fracture; Infiltracion de partes blandas por mieloma, tras la fijacion interna de una fractura patologica femoral

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, J.; Escape, I.; Bastart, F.; Solduga, C. [Hospital de Barcelona. Barcelona (Spain)

    2002-07-01

    a 75-year-old man with multiple myeloma presented with a pathologic fracture of distal right femoral diaphysis, which was fixed with Ender nails. Two and a half months later, the patients was readmitted with rapidly progressive swelling of right thigh. Ultrasound computed tomography and magnetic resonance imaging revealed infiltration of anterior right thigh muscles, extending upward to the iliopsoas muscle and retroperitoneal space, above ipsilateral renal vein. Ultrasound-guided biopsy of the soft tissue of the thigh revealed diffuse myelomatous infiltration by plasma blasts. (Author) 9 refs.

  1. O aprendizado da construção decaso clínico em saúde mental El aprendizaje de la construccion del caso clinico en salud mental Learning to construct a clinical case in mental health

    Directory of Open Access Journals (Sweden)

    Aline Maino Pergola

    2008-06-01

    Full Text Available Este estudo objetivou relatar a experiencia de uma aluna na construção de caso clinico em Saude Mental, desenvolvida nas disciplinas de Enfermagem em Saude Mental II e Enfermagem Psiquiátrica da Graduação em Enfermagem (Unicamp. Para estas disciplinas, a construção de caso é entendida como a articulação entre a entrevista psiquiátrica e alguns conceitos da teoria psicanalítica, aprendidos nas aulas, supervisao e leitura de textos, pretendendo estruturar um cuidado de Enfermagem coerente com a concepção de homem do referencial psicanalítico: um sujeito dividido pela existência do inconsciente, estruturado como linguagem. O relato baseou-se na experiência vivida pela aluna, durante as disciplinas, na produção de relatórios e construção de caso sob a forma de trabalho final. Foi possivel a aluna desenvolver a leitura do caso e construir uma teoria sustentadora do atendimento, por meio das demandas levantadas no diálogo com o paciente que direcionaram os pontos passíveis de intervenção.En este estudio se tuvo como objetivo relatar la experiencia de una alumna en la construcción del caso clínico en Salud Mental, desarrollada en las disciplinas de Enfermería en Salud Mental II y Enfermería Psiquiátrica del Pregrado en Enfermería (Unicamp. Para estas disciplinas, la construcción del caso es entendida como la articulación entre la entrevista psiquiátrica y algunos conceptos de la teoría psicoanalítica, aprendidos en las clases, supervisión y lectura de textos, pretendiendo estructurar un cuidado de Enfermería coherente con la concepción de hombre del referencial psicoanalítico: un sujeto dividido por la existencia del inconsciente, estructurado como lenguaje. El relato se basó en la experiencia vivida por la alumna, durante las disciplinas, en la producción de informes y construcción del caso bajo la forma de un trabajo final. Fue posible que la alumna desarrolle la lectura del caso y construir una teor

  2. Clinico-Pathological aspects of Shock

    Directory of Open Access Journals (Sweden)

    Kulkarni M.D.

    2009-08-01

    Full Text Available Shock can be defined as “a common grave medical emergency characterised basically by reduction in the effective circulating blood volume and blood pressure”. (Robbins or as “Disparity between the volume of blood and the volume capacity of the vascular system” which cause inability of body tissue to metabolise nutrients due to inadequate oxygen supply. Shock can be classified into: Primary and Secondary.Cardiogenic, Vasogenic, Hematogenic, Neurogenic and Electrocution. The therapy includes Blood, Plasma, Saline transfusion, antibiotic, antihistaminic, hyperimmune serum, vasoconstrictor according to the cause of the shock. [Vet. World 2009; 2(4.000: 163-165

  3. Clinico-Pathological aspects of Shock

    OpenAIRE

    Kulkarni M.D.; Yadav G.B.; Samant S.R.and Khanvilkar A.V.

    2009-01-01

    Shock can be defined as “a common grave medical emergency characterised basically by reduction in the effective circulating blood volume and blood pressure”. (Robbins) or as “Disparity between the volume of blood and the volume capacity of the vascular system” which cause inability of body tissue to metabolise nutrients due to inadequate oxygen supply. Shock can be classified into: Primary and Secondary.Cardiogenic, Vasogenic, Hematogenic, Neurogenic an...

  4. Disordered eating attitudes: demographic and clinico ...

    African Journals Online (AJOL)

    In addition, their blood pressure, height and weight were measured, and body mass index. (BMI) was .... as a profile of the eating attitudes of the sub-scale scores obtained, the ..... scale population studies using validated diagnostic tools.

  5. Clinico epidemiological study of pitted keratolysis

    Directory of Open Access Journals (Sweden)

    Naik Chandra

    2007-01-01

    Full Text Available Background: Pitted keratolysis is a common dermatological condition. However, very few studies are available on the clinical characteristics and epidemiological features of this disorder from India and abroad. Materials and Methods: Fifty patients from rural area of Kolar at Sri R.L.J.H. and S.N.R. Hospital, presenting with clinically distinctive lesions of pitted keratolysis were included in the study. Cases were interviewed with particular emphasis on triggering factors and findings were recorded. Investigations like Gram′s stain, culture studies, Wood′s ultraviolet light examination, histopathology etc, was done in selected cases to ascertain the clinical diagnosis. Results: Age of the patients varied from 20 to 40 years in 52% with male preponderance in 82% of cases. Duration of the disease varied from 15 days to five years, most of the patients were bare-footed farmers (62% of cases. Hyperhidrosis and pruritus were most frequently observed symptoms in 70% and 60% of patients. Most of the patients presented with the characteristic pits which varied from 1 to 50 in number in 56 % of cases, located predominantly on the pressure bearing areas in 92% of cases and depth of the pits varied from 1 to 2 mm in 60% of cases. Associated skin conditions recorded in present study were fissuring of soles in 38%, psoriasis 10%, dermatophyte infections in 6%, planter warts 6% and Corynebacterial triad and corn in 2% of patients each. Discussion: Affection of bare-footed individuals, male preponderance, presence of hyperhidrosis and occurrence of lesions over pressure bearing areas of soles, observed in the present study were consistent with earlier studies on the subject. However, pruritus as commonest presenting symptom reported by 60% patients in the present study, has not been documented in the previous studies. Conclusion: Pitted keratolysis is fairly common in bare footed male farmers of rural India. The condition is predominantly seen over the pressure bearing areas of sole and hyperhidrosis is common precipitating factor. Pruritus, a common presenting symptom observed in this study has not been reported earlier.

  6. Clinico-Pathological Study of Lung Carcinoma

    Directory of Open Access Journals (Sweden)

    SB Pradhan

    2014-09-01

    Full Text Available Background: Lung cancer is currently the most frequently diagnosed cancer in the world and the number one cause of cancer mortality worldwide.Materials and Methods: A descriptive study was conducted in 55 diagnosed lung carcinoma cases being treated in a Kathmandu based hospital over a period of 18 months from 22nd Oct. 2012 to 21st April 2014.Results: Out of total 55 lung carcinoma cases, 33 patients were male and 22 were female with Male: Female ratio of 1.5:1. The most frequent age group was 71-80 years. Lung cancer was more common among smokers (52.73 % of cases. Out of 47.27% non smokers, 76.92% were female. Squamous cell carcinoma was found to be the most common cancer type, comprising 63.64% of cases followed by adenocarcinoma (29.09% of cases and small cell carcinoma (7.27% of cases. Among various diagnostic methods, CT guided Fine needle aspiration cytology (FNAC and Pleural fluid cytology was found to be the best methods.Conclusion: Smoking showed a positive correlation among carcinoma of lung patients. Squamous cell carcinoma and adenocarcinoma were the most common tumors encountered among the smokers and non-smokers respectively. CT guided Fine needle aspiration cytology (FNAC and Pleural fluid cytology yields the most diagnostic materials.DOI:  http://dx.doi.org/3126/jpn.v4i8.11496   Journal of Pathology of Nepal; Vol4, No.8 (2014 623-625Background: Lung cancer is currently the most frequently diagnosed cancer in the world and the number one cause of cancer mortality worldwide.Materials and Methods: A descriptive study was conducted in 55 diagnosed lung carcinoma cases being treated in a Kathmandu based hospital over a period of 18 months from 22nd Oct. 2012 to 21st April 2014.Results: Out of total 55 lung carcinoma cases, 33 patients were male and 22 were female with Male: Female ratio of 1.5:1. The most frequent age group was 71-80 years. Lung cancer was more common among smokers (52.73 % of cases. Out of 47.27% non smokers, 76.92% were female. Squamous cell carcinoma was found to be the most common cancer type, comprising 63.64% of cases followed by adenocarcinoma (29.09% of cases and small cell carcinoma (7.27% of cases. Among various diagnostic methods, CT guided Fine needle aspiration cytology (FNAC and Pleural fluid cytology was found to be the best methods.Conclusion: Smoking showed a positive correlation among carcinoma of lung patients. Squamous cell carcinoma and adenocarcinoma were the most common tumors encountered among the smokers and non-smokers respectively. CT guided Fine needle aspiration cytology (FNAC and Pleural fluid cytology yields the most diagnostic materials.DOI: 3126/jpn.v4i8.11496   Journal of Pathology of Nepal; Vol4, No8(2014

  7. CLINICO-BACTERIOLOGICAL STUDY OF VESICAL CALCULUS

    Directory of Open Access Journals (Sweden)

    Pushpendra

    2016-05-01

    Full Text Available BACKGROUND Vesical calculi are the most common manifestation of lower urinary tract lithiasis. Urinary infections play an important role in aetiopathogenesis of vesical calculi. OBJECTIVE Aim of this study was proposed to establish the bacteriology of stone and urine in an attempt to evaluate the role of infection in the formation of stone. Associated factors like age, sex, site of infection, obstruction, diet were also evaluated. DESIGN Prospective cohort study. METHODS The patients were admitted in surgical ward as provisional diagnosed cases of vesical calculus, were subjected to investigations including CBC, RBS, urine analysis, renal function test, x-ray KUB region and ultrasonography. Patients who were fit for surgery, various surgical procedures were done. Gross examination and core culture of stone was done to establish their aetiology. RESULTS Ninety-four patients with vesical calculus were evaluated. Incidence of vesical calculus was 1.13%. Majority of cases were from rural areas (92.55%. Urinary tract infection was present in 37.2% of cases, majority of cases urine culture was positive (30.95%. Core culture of stone was positive in 18 cases (25.17%. E. coli was the predominant organism both in urine culture (19.04% and core culture of stone (25.71%. CONCLUSIONS There is significant association regarding the presence of vesical calculi and the development of urinary infections. E. coli was the predominant organism found both in urine and core culture of stone.

  8. Clinico-pathologic conference: case 4.

    Science.gov (United States)

    Ocampo-Acosta, Fabian; Robledo, Juliana; Aldape-Barrios, Beatriz; Garcia-Vazquez, Francisco J

    2009-12-01

    A 45 years old male patient presented with an asymptomatic right mandibular mass that extended from the angle to the premolar area. It had been present for 3 months at the time of the initial presentation. Panoramic radiograph revealed an ill-defined unilocular radiolucency. Previous dental treatment included molar extractions and antibiotic therapy. Considerable bleeding was encountered during incisional biopsy.

  9. ACUTE APPENDICITIS A CLINICO - RADIOLOGICAL STUDY

    Directory of Open Access Journals (Sweden)

    Govind

    2015-08-01

    Full Text Available Appendix Latin word means an addition or appendage was first identified as early as 3000 B.C. during the mummification process in Egypt. The prefix vermiform derived its name from its worm like appearance. Appendix was probably discovered by Celsus during dissecting criminal s executed by Caeser and was first depicted in anatomic drawings in 1492 by Leonardo da Vinci.

  10. Clinico-genealogical investigation of antiphospholipid syndrome

    Directory of Open Access Journals (Sweden)

    N N Chapaeva

    2009-01-01

    Full Text Available Objective. Clinicogenealogical investigation of the families of patients with antiphospholipid syndrome (APS. Material and methods. Families of 82 pts with APS fulfilled diagnostic criteria of S. Miyakis et al., 2006 (mean age 47,2±12,1 years, men:women ratio 1:10,7 were studied. “Severe” course of APS (43 patients was characterized by presence of recurrent thrombotic events and/or thrombosis of several types and/or localizations. Clinicogenealogical investigation included pedigrees analysis (the number of relatives - 615. 46 individuals-relatives of 26 patients with APS (37 first-degree and 9 second-degree relatives, mean age 29,5±16,4 years were followed up for 4 years. Incidence of “minor” features (livedo reticularis, neurological disorders, heart valves disease, thrombocytopenia was studied, lupus anticoagulant (LA test was performed. Statistical analysis was performed with Student’s t test and logistic regression analysis (SPSS 11.5.0. Results. Definite APS was diagnosed in 7 individuals, more frequently - in first-degree relatives and women (the most frequent form of inheritance - mother/daughter. “Minor” features were precursors of APS in 76% patients with APS. These features were found in more than half relatives. LA was detected in 39% of relatives. LA was 5-fold more prevalent in relatives of LA-positive patients with APS as compared with relatives of LA-negative patients. Primary prevention of thrombosis has been successfully conducted in patients with “minor” features of APS and/or positive LA (“pre-APS”. “Severe” course of APS was associated with the presence of cardiovascular diseases in family history (OR 0,32, CI0,11-0,97, multivariate analysis. Conclusion. Girls and first-degree relatives are at higher risk of APS development than boysand second- or third-degree relatives if APS is present in family history. LA, presumably, 39has inherited character. The role of clinicogenealogical method in APS: diagnosis of“pre-APS” and prediction of the disease course.

  11. [The postcoital test: clinico-laboratory observations].

    Science.gov (United States)

    Stanislavov, R; Nalbanski, B; Pŭnevska, M

    1999-01-01

    The choice of optimal time, the technique and limitations of the post-coital test (PCT) have been described. They are of important significance for getting reliable information both concerning the cervical mucus, quality and migration of spermatozoa in female genital tract. It has been stressed that a negative PCT does not necessary exclude pregnancy. There are shown data for prognostic value of the PCT. The observation of more than 20 motility spermatozoa per HPF and higher frequency of pregnancy is common finding in comparison to low motility and number of spermatozoa in cervical mucus. The data support the hypothesis of "filtering" mechanism, excluding entrance of abnormal spermatozoa. Observing "shaking" phenomenon directs to searching immunological factor (local or systemic) against male gametes.

  12. Clinico-Histologic Conferences: Histology and Disease

    Science.gov (United States)

    Shaw, Phyllis A.; Friedman, Erica S.

    2012-01-01

    Providing a context for learning information and requiring learners to teach specific content has been demonstrated to enhance knowledge retention. To enhance students' appreciation of the role of science and specifically histology in clinical reasoning, disease diagnosis, and treatment, a new teaching format was created to provide clinical…

  13. Losartan: il valore clinico ed economico

    Directory of Open Access Journals (Sweden)

    Lorenzo Pradelli

    2004-03-01

    Full Text Available Losartan is an angiotensin II receptor antagonist (ARB that has been proven effective and well tolerated in the treatment of hypertension and in the reduction of global cardiovascular risk, but is more expensive than many alternatives. The present paper resumes its main pharmacological and clinical features, as a basis for analyzing its economical value. Despite the universally accepted relevance of good blood pressure control, hypertension is still undertreated and poorly controlled. Among the main reasons for this, poor adherence to therapeutic regimens plays a relevant role. Losartan and ARBs have been shown to be associated with compliance rates superior to those observed with any other antihypertensive drug class, due to an adverse events incidence similar to placebo and scarcity of relevant pharmacological interactions, and can therefor improve the cost-effectiveness of hypertension treatment. Several trials have indicated that losartan determines clinical benefits that go beyond its haemodynamic effect, such as renal protection, reduced incidence of stroke and cognitive improvement. The addition of losartan to conventional hypertensive therapy in diabetic patients with nephropathy has been estimated to induce net health cost savings in different settings, a relevant result, as very few medical interventions have demonstrated such a potential. To understand the real economical value of losartan, its drug acquisition costs have to be balanced against the benefits deriving from antihypertensive effectiveness, high compliance and non-haemodynamic target organ protection.

  14. Inappropriatezza prescrittiva delle colonscopie: un audit clinico

    OpenAIRE

    Matteo Marcosignori; Ivano Lorenzini; Luigi Maria Tomarelli

    2012-01-01

    Background. La colonscopia è una tecnologia diagnostico-terapeutica ad ampia diffusione, ma ad elevato rischio di inappropriatezza. Infatti, la letteratura ha più volte ribadito la necessità di strategie per verificarne l’appropriatezza prescrittiva, suggerendo gli strumenti necessari per raggiungere questo obiettivo. Nella zona di Ancona si è assistito negli ultimi anni ad un continuo incremento del numero di richieste di colonscopie con conseguente allungamento delle liste di attesa e aumen...

  15. Clinico-statistical study on radiotherapy prostheses

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, Takaaki; Taniguchi, Hisashi; Sunahara, Yuichi; Shinozuka, Osamu; Suzuki, Ruri; Ohyama, Takashi; Takeda, Masamune [Tokyo Medical and Dental Univ. (Japan). School of Dentistry

    1996-06-01

    Various radiotherapy prostheses, including spacer, protector, carrier and mold, are frequently used for oral and maxillofacial cancer patients because they enhance the treatment efficacy of radiotherapy and protect adjacent normal tissue from irradiation. Therefore a clinical investigation was carried out on 310 cases of radiotherapy prostheses applied in our clinic from 1981 to 1995. The results were as follows: Sex ratio (male: female) of patients was 1.67: 1 and the number of the patients at the age of 60-69 was the largest. Spacer accounted for 81.0% of prostheses, followed by mold (10.6%), protector (5.5%) and carrier (2.9%). As for the site of malignant tumor, the tongue was 77.1% of all cases. External irradiation was already performed on 23.3% of all cases. Abutment teeth remained in 85.9% of 304 cases in which the prostheses were applied intraorally. The average time to make the prostheses was 12.4 days. As for the retention of the prosthesis to the mouth, a ball clasp was used most frequently in spacer and carrier, and overlay type was applied most frequently in mold and protector. As for the retention of shield to carrier in mold cases, mechanical interlocking of the resin parts of carrier and shield was 75.8% of the cases. (author)

  16. Clinico-laboratory study on filarial lymphoedema

    Directory of Open Access Journals (Sweden)

    Mohamad A Ebrahim

    2012-01-01

    Full Text Available Context: Lymphatic filariasis is considered the second leading cause of permanent physical disability in humans next to mood disorder. Aims: To evaluate filarial lymphoedema as a considerable burden to patients and the community. Settings and Design: This study was conducted on 45 patients with filarial lymphoedema among 2,350 patients with lower limb edema and 22 age- and sex-matched controls, from May 2005 to May 2008. Materials and Methods: Subjects were subjected to full history taking, clinical examination, Doppler ultrasound on the affected leg, laboratory tests for filariasis. Statistical Analysis: Data were analyzed using the Statistical Package for Social Scientist (SPSS for windows 7.5. (SPSS Inc, Chicago, USA. Results: Male to female ratio was approximately 1:1.8. The age group 21-30 years was more affected (42%. The majority of cases of filarial lymphoedema in the present study were diagnosed in advanced irreversible stages. Five patients had hydrocele. Four cases (8.9% were detected to be microfilaremic, 60% of cases were positive for Immunoglobulin (Ig G, 4.44% were IgM positive and positive cases for filarial antigenemia were 64.4%. Conclusion: The majority of cases in the present study were detected in advanced irreversible stages with patient disability and serious socioeconomic impact.

  17. CLINICO-AETIOPATHOLOGICAL STUDY OF ERYTHRODERMA

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    Chetana

    2015-10-01

    Full Text Available Erythroderma refers to any inflammatory skin disease affecting either sex or any age group resulting in erythema and exfoliation that affects more than 90% of the body surface. It may result from a pre-existing dermatoses or underlying lymphoma, drug eruption, hereditary causes eg: ichthyosiform erythroderma. Hence it is mandatory to establish the cause in order to facilitate its management.Since it is a complex disorder, the patient should preferably be hospitalized for evaluation and treatment. To study the clinical profile of patients with erythroderma and to identify the aetiological factors of erythroderma and its histopathological correlation and also it’s associated systemic complication. A total number of 57 clinically diagnosed cases of erythroderma attended the department during the period from 2012 to 2014 and were taken up for the clinio-aetiopathological evaluation. Males out-numbered females with a ratio of 1.48:1. Predominant symptoms were erythroderma (96.49%, exfoliation (100%, itching (100%. Nail change were seen in 75.43% of patients. The most common underlying etiology observed was psoriasis (43.85% followed by drug inducted erythroderma (36.84%. The most common reaction pattern observed was psoriasiform pattern (59.6%. In 16 (33.33% patients biopsy helped in reaching the diagnosis.Erythroderma can be fatal, even when properly managed, primarily because of its metabolic complications. Hence it is mandatory to establish its aetiopathology in order to facilitate more practiced management apart from the routine basic management.

  18. Clinico-Histologic Conferences: Histology and Disease

    Science.gov (United States)

    Shaw, Phyllis A.; Friedman, Erica S.

    2012-01-01

    Providing a context for learning information and requiring learners to teach specific content has been demonstrated to enhance knowledge retention. To enhance students' appreciation of the role of science and specifically histology in clinical reasoning, disease diagnosis, and treatment, a new teaching format was created to provide clinical…

  19. Profilo clinico ed economico di oxatomide

    Directory of Open Access Journals (Sweden)

    Lorenzo Pradelli

    2003-12-01

    Full Text Available Oxatomide is an antiallergic drug with a double mechanism of action: it possesses antagonistic activity on the H1 histaminergic receptor and it inhibits the production and release of flogistic and allergic mediators by effector cells, presumably acting as a selective calcium channel blocker on these cellular types. The efficacy and safety of oxatomide have been evaluated in many studies conducted on patients affected by different clinical conditions, demonstrating remarkable flexibility. It proved to be safe and effective also in extreme ages, i.e. children under 3 months of age and elderly over 80 years. Approved indications include rhinitis, asthma, conjunctivitis, urticaria, atopic and allergic dermatitis and food allergy and intolerance. In direct comparisons, oxatomide consistently proved superior than placebo and equally or more effective than other consolidated antiallergics. The drug tolerability is good, its main side effects are drowsiness and weight gain, usually transient. Cardiac and hepatic safety data are very reassuring, as is the case for drug interaction potential. Form an economical point of view, the drug acquisition cost is acceptable, being among the lowest in its class, at equally effective doses. Overall, the efficacy in several clinical conditions, the good tolerability in most patients and the reasonable purchase cost suggest that oxatomide is characterized by excellent risk-to-benefit and cost-to-benefit ratios in the treatment of allergic pathologies.

  20. 胆管细胞性肝癌的血管新生及临床病理意义%Angiogenesis in cholangiocellular carcinoma and clinico-pathological significance

    Institute of Scientific and Technical Information of China (English)

    汤地; 梁力建; 黄洁夫; 永野皓昭

    2005-01-01

    [Objective] To elucidate the angiogenesis status of CCC, the relationship with well known angiogenic factors and clinico-pathological means. [Methods] 33 specimen of surgically resected CCC were investigated. Angiogenesis of tumor was assessed by routine microvessel density counting using anti-CD34 antibody. Immunohistochemical Staining of VEGF Ang-1 Ang-2 and TSP-1 were carried out. [Results] The mean MVD is (87.2±52.6),with a ranged of from 10 to 229. VEGF expression is positive in 75.6% cases; Ang-1 expression is positive in 36%cases; Ang2 positive is positive in 57.6% of cases and 45.5% cases exhibited positive TSP-1 expression. VEGF and Ang-2 expression were found to be associated with significant higher level of MVD (P =0.004 and 0.015 respectively). TSP-1 expression was found to be associated with significant low level of MVD (P =0.005). Positive TSP-1 expression was also found to be associated with higher level of intrahepatic metastasis (46.7% vs. 5.6%, P =0.012). Except that, there was no significant correlation between VEGF, Ang-1, Ang-2 and TSP-1expression and tumor size,capsule formation, infiltration of capsule, portal vein invasion, intrahepatic metastasis or differentiation of the CCC has been found. No significant correlation between MVD levels, VEGF, Ang-1, Ang-2, TSP-1 expression and postoperative survival has been found. [Conclusion] Considerable angiogenesis comparable to other solid tumors are observed in CCC. VEGF and Ang2 may play a proangiogenic role and TSP-1 may play an inhibitory role. Although TSP-1 may increase the intrahepatic metastasis of CCC, neither MVD levels nor the expression of VEGF, ANG1, or ANG2 is associated with tumor invasiveness and prognosis.%目的目前关于胆管细胞性肝癌(CCC)的血管新生研究较少,本研究的目的在于描述CCC的血管新生的特点,其与血管新生调控因子之间的关系以及临床-病理意义.方法调查33例手术切除的CCC标本.肿瘤

  1. Clinico-radiological features and treatment of intracranial cavernous angiomas%颅内海绵状血管瘤的影像特点及治疗分析

    Institute of Scientific and Technical Information of China (English)

    陈彤; 郭亮

    2016-01-01

    Objective To investigate the clinico-radiological features and treatment of intracranial cavernous angiomas. Methods The clinical and radiological data of 52 patients who confirmed with pathology or follow-up were analyzed retrospectively. The CT,.MRI features and the management of cavernous angiomas were evaluated emphatically. Results Among 52 cases,.48 cases had single lesion and 4 had multiple lesions,.totally 63 lesions..There were 54 intracerebral cavernous angiomas and 9 extracerebral cavernous angiomas..Intracerebral cavernous angiomas occurred mostly in supratentorial brain parenchyma , especially in frontal and temporal lobes.(38/54,70.37%). Cavernomas usually manifested as high density and well-defined lesions, sometimes with calcifications on CT..There was no mass effect on adjacent structures..The MRI features were complex and changeable. According to the classification, typeⅡwas the most common category (32/54, 59.26%). Both T1 and T2-weighted images showed heterogenous signal intense and presented as “mulberry” or “popcorn”. A hypointense rim in the surrounding brain parechyma is another feature of cavernous angiomas. (46/54,.85.18% )..On contrast -enhanced MRI,.cavernomas performed as minimal enhancement (59.26%) or non-enhancement (40.74%). Extracerebral cavernous angiomas often occurred in cavernous sinus , and were characterized by high signal intensity on T2WI and significantly enhancement with mass effect. 39 cases underwent surgery (39/52, 75%), 5 cases underwent γ knife radiosurgery (5/52, 9.62%) and 8 cases chose conservative treatment (8/52, 15.38%). After surgery, there were hemorrhage in 4 cases and neurological impairment in 3 cases. Conclusion The CT and MRI features of intracranial cavernous angiomas have a high value in the diagonosis and could provide some guidance on the treatment. Surgery was the main choice for most cavernomas ,.conservative treatment or radiosurgery could become another alternative to surgery.%目的

  2. Clinico-pathologic characteristics of different molecular subtypes of 146 young breast cancer cases%146例不同分子亚型年轻乳腺癌的临床病理特征分析

    Institute of Scientific and Technical Information of China (English)

    段海明; 陈晶; 王娜; 王闽全; 欧江华

    2015-01-01

    Objective To study the clinico-pathologic characteristics of different molecular subtypes of young breast cancer patients. Methods The clinical data of 146 breast cancer patients (≤40 years old)treated in Department of Breast Surgery,The Cancer Hospi-tal Affiliated to Xinjiang Medical University and Department of Oncology,Second Affiliated Hospital of Xinjiang Medical University, from January 2012 to April 2014 were retrospectively analyzed.These 146 patients,all diagnosed as invasive cancer,were categorized in-to four molecular subtypes:Luminal A,Luminal B,HER2 over-expression and Basal-like,based on the expression of ER,PR,HER2 and Ki-67.Then the differences in clinical pathological characteristics among different molecular subtypes were analyzed.Results There were 24 patients in Luminal A subtype,77 in Luminal B subtype,17 in HER2 over-expression subtype,and 28 in Basal-like subtype. There were statistically significant differences among different molecular subtypes regarding the tumor size and histological grade,howev-er ,there were no statistically differences regarding the pathological type,lymph node metastasis and clinical stage.Conclusions A-mong different molecular subtypes of young breast cancer there are statistically significant differences in some clinical pathological char-acteristics,which indicate that different molecular subtypes may have different characteristics in treatment and prognosis.Therefore,it will provide a theoretical basis for individual treatment in breast cancer.%目的探讨不同分子亚型年轻乳腺癌的临床及病理特点。方法回顾性分析新疆医科大学附属肿瘤医院乳腺外科及新疆医科大学第二附属医院肿瘤外科2012年1月—2014年4月收治的146例均经术后病理证实的浸润性乳腺癌患者的临床资料(年龄均≤40岁),按照患者乳腺癌组织 ER(雌激素受体),PR(孕激素受体),HER-2(人表皮生长因子受体2),Ki-67(肿瘤细胞增殖相

  3. 结肠癌患者贫血与肿瘤大体分型及临床病理分期的关系%Relationship between Anemia in Colon Cancer and General Classification and Clinico-pathological Staging of Colon Cancer

    Institute of Scientific and Technical Information of China (English)

    黄国定

    2015-01-01

    Objective To study the relationship between anemia in colon cancer and general classification and clinico-pathological staging of colon cancer.Methods 160 cases of colon cancer were divided into anemic group and non-anemic group. Tumor size,gross type,clinical staging and other general situation of the 2 groups were compared;Blood routine and iron metabo-lism indexes in different general classification and clinicopathological staging were compared.Results The tumor diameter >4 cm,general type of invasion,cliniopathological stage C,D ratio in anemia group was significantly higher than that of non-anemic group,P4 cm、大体分型为浸润型、临床病理分期C、D期者比例显著高于非贫血组,P<0.05. 浸润型红细胞、血红蛋白、血清铁和铁蛋白水平均显著低于非浸润型,P<0.01. C、D期红细胞、血红蛋白、血清铁和铁蛋白水平均显著低于A、B期,P<0.01. 结论 结肠癌患者贫血与肿瘤大体分型及临床病理分期有一定相关性.

  4. Estudio clinico micologico de onimicosis en ancianos Clinico-mycological study of onychomycosis in elderly patients

    Directory of Open Access Journals (Sweden)

    Mayda Elena Rodriguez-Soto

    1993-06-01

    Full Text Available Se realizó examen físico de las uñas a 210 ancianos y a aquellos que presentaron lesiones sugestivas de onicomicosis se les realizó toma de muestra con el objetivo de conocer los principales agentes causales, las características e incidencia de las lesiones. Se confirmó el diagnóstico mediante el aislamiento del agente causal en 74 de los casos procedentes principalmente de las uñas de los pies, para una incidencia de 35,2. La tinea pedis se presentó en el 25,7% de los casos, mientras que la enfermedad asociada más frecuente fue la Diabetes mellitus; entre las características clínicas de las uñas predominaron el engrosamiento, la pérdida del brillo y la aparición de estrías longitudinales. Existió una correspondencia significativa entre el examen microscópico directo y el cultivo. La especie de dermatofito predominate fue Trichophyton rubrum, mientras que Candida parapsilosis fue la más aislada entre las especies de Candida.Physical examination of nails was carried out in 210 elderly patients and nail scrapings were obtained from onychomycosis suggested lesions in order to determine their causative agents, incidence and clinical characteristics. Diagnostic was confirmed by the isolation of the agents from 74 patients, mainly from toe-nails (incidence 35,2. Tinea pedis occurred in 25% of the cases and Diabetes mellitus was the most prevalent associated disease and the most frequent clinical characteristics were the thickening, the opacity and the presence of longitudinal strias in the surface of the nails. It was compared the results obtained by microscopic examination and by culture. Trichophyton ru-brum was the most common dermatophyte isolated; Candida parapsilosis was dominant among Candida species.

  5. [Bilateral carotid artery occlusion: prognosis and neurosonological features].

    Science.gov (United States)

    Pérez-Sánchez, Javier R; García-Pastor, Andrés; Díaz-Otero, Fernando; Sobrino-García, Pilar; Rodríguez-Cruz, Pedro M; Vicente-Peracho, Gema; Vázquez-Alén, Pilar; Fernández-Bullido, Yolanda; Villanueva-Osorio, José A; Gil-Núñez, Antonio

    2014-07-16

    Introduccion. La oclusion carotidea bilateral (OCB) es una entidad infrecuente y poco estudiada. El pronostico a medio y largo plazo comunicado es variable. La circulacion colateral desempeña, probablemente, un papel crucial en su pronostico; sin embargo, existen pocos trabajos en la bibliografia al respecto. Objetivo. Describir el pronostico y las caracteristicas neurosonologicas de una serie de pacientes con OCB. Pacientes y metodos. Se seleccionaron pacientes del laboratorio de neurosonologia por un periodo de cinco años. El diagnostico de OCB se realizo mediante ultrasonografia duplex y se confirmo con angiotomografia computarizada o angiografia convencional. Se registraron las variables clinico-diagnosticas, el seguimiento de recurrencias, y se realizo un estudio neurosonologico completo y un test de reserva hemodinamica cerebral (RHC) con acetazolamida intravenosa. Resultados. Se revisaron 2.780 estudios neurosonologicos y se confirmo el diagnostico de OCB en 10 pacientes. Ocho pacientes se diagnosticaron a raiz de una isquemia cerebral. Se realizo un seguimiento medio de 2,7 años. Un paciente presento un ataque isquemico transitorio carotideo derecho durante el seguimiento, lo que resulto en una tasa anual de ictus isquemico del 4,1%. Seis se mantuvieron funcionalmente independientes y dos fallecieron. Se realizo un estudio neurosonologico completo en seis pacientes, y se evidencio una circulacion colateral extensa y RHC patologica en todos. El paciente que sufrio la recurrencia presento una RHC exhausta y circulacion colateral desfavorable en el hemisferio sintomatico. Conclusiones. En la serie estudiada, los pacientes con OCB presentaron una baja tasa de recurrencias cerebrovasculares. Una RHC patologica y una circulacion colateral insuficiente podrian relacionarse con un mayor riesgo de recurrencias.

  6. Motor neuron diseases in the University Hospital of Fortaleza (Northeastern Brazil: a clinico-demographic analysis of 87 cases Doenças do neurônio motor no Hospital Universitário de Fortaleza (Nordeste do Brasil: análise clínico-demográfica de 87 casos

    Directory of Open Access Journals (Sweden)

    CARLOS M. DE CASTRO-COSTA

    2000-12-01

    Full Text Available In this retrospective (1980-1998 study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil, a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs. Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA, 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP, 2 as progressive muscular atrophy (PMA and 1 as monomelic amyotrophy (MA, and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17, 30 to 39 years (n= 18, 40 to 69 years (n= 39 and 70 to 78 years (n= 4. From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS.Neste estudo retrospectivo (1980-1998, analisamos clínico-demograficamente, a partir dos prontuários do Hospital Universitário de Fortaleza (Brasil, um grupo de 87 pacientes que apresentavam sinais e sintomas de doenças do neurônio motor (DNMs. Eles foram diagnosticados clinicamente, e através de exames complementares. Para o diagnóstico da esclerose lateral amiotrófica (ELA, usamos os critérios da Federação Mundial de Neurologia. A análise clínico-demográfica dos 87 casos de DNMs evidenciou a existência de 4 casos de atrofia muscular espinhal (AME, 5 casos de variantes da ELA: 2 de paralisia bulbar progressiva (PBP, 2 de atrofia muscular progressiva (AMP e 1 de amiotrofia monomélica (AM, e 78 casos de ELA. Esses últimos eram constituídos de 51 homens e 27 mulheres, com

  7. Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus

    Directory of Open Access Journals (Sweden)

    Kyung-Ja Cho

    2017-07-01

    Full Text Available Background Basaloid squamous cell carcinoma (BSCC is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has been suggested to originate from a totipotent primitive cell in the basal cell layer of the surface epithelium or in the proximal duct of secretory glands. Methods Twenty-six cases of head and neck BSCC from Asan Medical Center, Seoul, Korea, reported during a 14-year-period were subclassified into basal, ductal, and mixed subtypes according to the expression of basal (cytokeratin [CK] 5/6, p63 or ductal markers (CK7, CK8/18. The cases were also subject to immunohistochemical study for CK19, p53, cyclin D1, epidermal growth factor receptor (EGFR, and p16 and to in situ hybridization for human papillomavirus (HPV, and the results were clinico-pathologically compared. Results Mixed subtype (12 cases was the most common, and these cases showed hypopharyngeal predilection, older age, and higher expression of CK19, p53, and EGFR than other subtypes. The basal subtype (nine cases showed frequent comedo-necrosis and high expression of cyclin D1. The ductal subtype (five cases showed the lowest expression of p53, cyclin D1, and EGFR. A small number of p16- and/or HPV-positive cases were not restricted to one subtype. BSCC was the cause of death in 19 patients, and the average follow-up period for all patients was 79.5 months. Overall survival among the three subtypes was not significantly different. Conclusions The results of this study suggest a heterogeneous pathogenesis of head and neck BSCC. Each subtype showed variable histology and immunoprofiles, although the clinical implication of heterogeneity was not determined in this study.

  8. [Encephalopathy and neuromyelitis optica: the importance of recognising atypical symptoms].

    Science.gov (United States)

    Hervás-García, José V; Grau-López, Laia; Doménech-Puigcerver, Sira; Ramo-Tello, Cristina

    2014-01-01

    Introduccion. La neuromielitis optica (NMO) o enfermedad de Devic es un trastorno autoinmune, inflamatorio y desmielinizante del sistema nervioso central, que afecta principal y caracteristicamente al nervio optico y a la medula espinal. Los anticuerpos antiacuaporina-4 (AQ-4) son un biomarcador especifico de esta entidad y, desde su descubrimiento, se ha ampliado el numero de sintomas y datos radiologicos de la enfermedad y se ha definido el concepto de espectro clinico de NMO. Caso clinico. Mujer de 66 años diagnosticada de NMO por haber sufrido brotes de neuritis optica y mielitis de repeticion junto con anticuerpos AQ-4 positivos. Presento un cuadro de disminucion del nivel de conciencia, con resonancia magnetica cerebral que mostro multiples lesiones en la sustancia blanca, sin realce de contraste, que se resolvio sin tratamiento. Un mes despues, sufrio empeoramiento del estado general, sindrome confusional y ceguera. En la resonancia magnetica cerebral se observaron nuevas lesiones en la sustancia blanca y aumento del tamaño de otras ya existentes. Se emitio el diagnostico de encefalopatia en el contexto de NMO y se trato a la paciente con corticoides e inmunoglobulinas intravenosas, con lo que se produjo mejoria clinica y radiologica. Conclusiones. Desde el descubrimiento de los anticuerpos AQ-4, ha aumentado el numero de manifestaciones clinicas y radiologicas de la NMO mas alla de la afectacion del nervio optico y de la medula espinal, entre ellas las manifestaciones cerebrales. Reconocerlas es muy importante para hacer un diagnostico precoz, evitar pruebas complementarias no necesarias e instaurar el tratamiento adecuado.

  9. 食管癌伴神经内分泌分化的临床病理特点及诊断标志物%Clinico-pathological characteristics and diagnostic biomarkers in patients with esophageal carcinoma accompanied by neuroendocrine cell differentiation

    Institute of Scientific and Technical Information of China (English)

    刘连科; 邵明雯; 马兰; 孙婧; 管丹; 束永前

    2015-01-01

    Objective To investigate the clinico-pathological characteristics and diagnostic markers in esophageal carci-noma accompanied by neuroendocrine cell differentiation (E-NED).Methods The clinico-pathological data of 378 patients with poorly differentiated esophageal carcinoma from Jan.2008 to Dec.2013,including 349 without neuroen-docrine differentiation (E-NNED)and 29 with neuroendocrine differentiation (E-NED),were retrospectively analyzed. The expressions of synaptophysin (SYN),chromogranin A (CgA),neuron-specific enolase (NSE),neural cell adhe-sion molecule (CD56),protein gene product (PGP9.5 ),secretagogin (SCGN)and thyroid transcription factor 1 (TTF-1)in the esophageal carcinoma tissues of 29 patients with E-NED and 20 ones randomly selected from the 349 patients with E-NNED were detected using immunohistochemistry.Results There were no significant differences between the patients with E-NED and E-NNED in terms of the age,gender,length of lesion and other clinico-pathologi-cal factors.Except for TTF-1,the expressions of Syn,CgA,NSE,CD56,PGP9.5 and SCGN were significantly higher in patients with E-NED than those with E-NNED (P diagnostic accuracy were all higher in the combined detection of Syn and CD56,PGP9.5 or SCGN than Syn and CgA (P <0.05).There were no significant differences between the patients with E-NED and E-NNED regarding 1,2 and 3-year survival rates.Conclusion E-NED and E-NNED may be different pathological types of esophageal carcinoma. Both PGP9.5 and SCGN can be considered as the diagnostic markers of E-NED,and the combined detection of Syn and CD56,PGP9.5 or SCGN can improve the sensitivity and diagnostic accuracy.%目的:探讨食管癌伴神经内分泌分化(E-NED)的临床病理特点及诊断标志物。方法回顾性分析2008年1月至2013年12月经病理证实的低分化食管癌378例患者的临床病理资料,其中无 NED(E-NNED)349例, E-NED 29例,免疫组织化学检测29例 E-NED 以及随机选取20例 E

  10. Laparoscopic and ultrasound assisted management of gallstone ileus after biliointestinal bypass Case report and a review of literature.

    Science.gov (United States)

    Zago, Mauro; Bozzo, Samantha; Centurelli, Andrea; Giovanelli, Alessandro; Vasino, Michele Ciocca

    2016-05-24

    L’ileo biliare (IB) è una rara urgenza chirurgica, secondaria alla formazione di una fistola colecisto-enterica. È una patologia ancora gravata da una elevata mortalità (15-18%), soprattutto perchè prevalente nella popolazione anziana. L’IB si manifesta con i sintomi aspecifici dell’occlusione intestinale (dolore e distensione addominale, alvo chiuso a feci e gas, vomito) e, per tale ragione, la diagnosi eziologica preoperatoria non è frequente. La triade radiologica di Rigler (pneumobilia, presenza di un calcolo ectopico, livelli idro-aerei) è patognomonica, ma identificabile solo in circa il 15% dei casi alla radiografia dell’addome. A motivo della rarità della patologia, non vi è unanime consenso circa il trattamento dell’IB. In letteratura sono pochi i lavori che riportano l’insorgenza di IB in pazienti precedentemente sottoposti a chirurgia bariatrica. La revisione della letteratura ha permesso di reperire tre casi di ileo biliare successivi a chirurgia bariatrica, di cui due conseguenti a bypass biliodigestivo. Viene presentato un ulteriore caso di una paziente di 41 anni che ha sviluppato un ileo biliare otto anni dopo un intervento bariatrico di bypass bilio-intestinale laparoscopico. Nei pazienti sottoposti a intervento di bypass bilio-digestivo per obesità patologica, viene confezionata una anastomosi tra la colecisti ed il digiuno in modo da conservare la circolazione enteropatica, riducendo le conseguenze del malassorbimento. L’analisi della letteratura relativa ai casi di ileo biliare post-bariatrici pubblicati e di quella più generale sull’ileo biliare, permette di elaborare considerazioni di pratica utilità inerenti la diagnosi pre-operatoria, il ruolo dell’ecografia nella pianificazione della strategia chirurgica e il trattamento chirurgico laparoscopico a cui è stata sottoposta la paziente.

  11. Sporadic Creutzfeldt-Jakob disease: a clinico-neuropathological analysis of nine definite cases Doença de Creutzfeldt-Jakob do tipo esporádico: análise clínico-neuropatológica de nove casos da forma definida

    Directory of Open Access Journals (Sweden)

    CARLOS M. DE CASTRO COSTA

    1998-09-01

    Full Text Available The authors have analyzed clinico-neuropathologically nine cases of the definite sporadic form of Creutzfeldt-Jakob disease (CJD. All cases were female, with mean age of 62.7 years. Eighty-nine percent of the patients exhibited prodromal and initial psychiatric symptoms; definite signs of dementia, and myoclonus were present in 100% of cases. The EEG was abnormal in all cases and pseudoperiodic paroxysms were present in 56% of the patients. Their evolution time ranged from 3 to 19 months. Neuropathologically, brain and cerebellar atrophy, spongiosis, astrocytosis and neuronal loss were present in 100% of the patients. In 5 (56% of these 9 cases, prion protein (PrP amyloid plaques were detected in the cerebellum, by optical- and electronmicroscopy. There was a positive correlation between the number of plaques and the evolution time. The authors outline the similarities of their cases in the elderly with the new variant of CJD described in young people.Os autores analisaram, do ponto de vista clínico e neuropatológico, nove casos da forma esporádica definida da doença de Creutzfeldt-Jakob (DCJ. Todos eles eram mulheres, com idade média de 62,7 anos. Oitenta e nove por cento dos pacientes exibiram sintomas psiquiátricos prodrômicos e iniciais; sinais típicos de demência e mioclonias estavam presentes em 100% deles. O EEG foi anormal em todos os casos e apresentou paroxismos pseudoperiódicos em 56% dos pacientes. O tempo de evolução da doença variou de 3 a 19 meses. Do ponto de vista neuropatológico, atrofia cerebral e cerebelar, espongiose, astrocitose e perda neuronal estavam presentes em 100% dos pacientes. Em 5 (56% dos 9 casos, foi evidenciada, por microscopia óptica e eletrônica, a presença de placas amilóides de proteína prion (PrP no cerebelo. Havia correlação positiva entre o número de placas e o tempo de evolução da doença. Os autores salientam as semelhanças desses seus casos de pacientes idosos com a nova

  12. Acute subdural hematoma and diffuse axonal injury in fatal road traffic accident victims: a clinico-pathological study of 15 patients Hematoma subdural agudo e lesão axonal difusa em vítimas fatais de acidente de trânsito: estudo clínico-patológico de 15 pacientes

    Directory of Open Access Journals (Sweden)

    Sebastião Nataniel Silva Gusmão

    2003-09-01

    Full Text Available OBJECTIVE: Although acute subdural hematoma (ASDH and diffuse axonal injury (DAI are commonly associated in victims of head injury due to road traffic accidents, there are only two clinico-pathological studies of this association. We report a clinical and pathological study of 15 patients with ASDH associated with DAI. METHOD: The patients were victims of road traffic accidents and were randomly chosen. The state of consciousness on hospital admission was evaluated by the Glasgow coma scale. For the identification of axons the histological sections of the brain were stained with anti-neurofilament proteins. RESULTS: Twelve of the 15 patients were admitted to hospital in a state of coma; in three patients, the level of consciousness was not evaluated, as they died before hospital admission. CONCLUSION: The poorer prognosis in patients with ASDH who lapse into coma immediately after sustaining a head injury, as described by several authors, can be explained by the almost constant association between ASDH and DAI in victims of fatal road traffic accidents.OBJETIVO: Embora o hematoma subdural agudo (HSDA e a lesão axonal difusa (LAD estejam frequentemente associados em vítimas de trauma crânio-encefálico causado por acidentes de trânsito, há somente dois estudos clínico-patológicos sobre esta associação. Relatamos o estudo clínico-patológico de 15 pacientes com HSDA associado com LAD. MÉTODO: Os pacientes, vítimas de acidentes de trânsito, foram selecionados aleatoriamente. O estado de consciência à admissão hospitalar foi avaliado pela escala de coma de Glasgow. Para a identificação dos axônios, os cortes histológicos do cérebro foram corados com antisoro anti-proteínas do neurofilamento. RESULTADOS: Doze dos 15 pacientes foram admitidos no hospital em estado de coma; em três pacientes, o nível de consciência não foi avaliado, pois eles faleceram antes da admissão hospitalar. CONCLUSÃO: O pior prognóstico em pacientes

  13. A clinico-pathological study of primary adrenal lymphoma(report of 2 cases)%原发性肾上腺恶性淋巴瘤临床病理学研究(附二例报告及文献复习)

    Institute of Scientific and Technical Information of China (English)

    徐新宇; 石群立; 孟奎

    2001-01-01

    目的 探讨原发性肾上腺恶性淋巴瘤的临床及病理学特点。 方法 分析2例原发性肾上腺恶性淋巴瘤病例资料,并进行组织形态学观察和免疫组织化学检测。 结果 2例患者年龄分别为45岁及57岁,临床上无特异性,组织学上瘤细胞呈弥散分布,其间可见薄壁小血管,瘤细胞多呈圆形或卵圆形,胞浆少,核深染,异形明显,可见核分裂像。免疫组化染色LCA、L26、CD74阳性,UCHL-1阴性,S-100蛋白及CK阴性。2例病人中1例术后3个月因明显恶液质体征自动出院,1例失访。 结论 原发性肾上腺恶性淋巴瘤是一种罕见的、恶性程度较高的肿瘤,诊断依赖于组织病理学及免疫组织化学标记检查。%Objective To study the clinico-pathological features of primary adrenal lymphoma (PAL). Methods 2 cases of PAL were reviewed and studied. Results The age of the 2 patients was 45 and 57.The presenting symptoms were nonspecific.Histologically,the neoplasm was composed of numerous medium-sized cells with round nucleus,usually 1-2 in number and with relatively abundant basophilic cytoplasm.The neoplastic cells showed frequent mitosis.Immunohistochemically,the tumor cells were strongly positive for LCA,L26 and CD74 while negative for UCHL-1,S-100 protein and CK. One case was discharged 3 months after operation because of dyscrasia and the other was lost on follow up.Prognosis of PAL was poor. Conclusions PAL is extremely rare with a high grade of malignancy.The diagnosis could be made on histopathological studies and immunohistochemical studies.

  14. 呈慢性肾炎的IgA肾病96例临床病理和预后分析%Analysis of clinico-pathological characteristics and prognosis in 96 patients of IgA nephropathy with chronic glomerulonephritis

    Institute of Scientific and Technical Information of China (English)

    徐晓燕; 黄朝兴

    2011-01-01

    Objective: To discuss the early diagnostic criterion of chronic glomerulonephritis in primary IgA Nephropathy (IgAN). Methods: From march 1993 to august 2009, 96 biopsy-proven IgAN patients from The First Affiliated Hospital of Wenzhou Medical College with serum creatinine level above the upper limit (Scr≥ 105 μ mol/L by picric kinetic method) were enrolled in this study. The patients were divided into two groups according to creatinine clearance rate (Ccr): Group A (Ccr≥ 60 mL/min, n=43), and group B (Ccr<60 mL/min, n=53). Two groups of patients with clinico-pathological characteristics and prognosis were compared and analyzed. Endpoint was defined as double of baseline serum creatinine or Ccr<15 mL/min.Results:Among 96 cases with IgAN, incidence of proteinuria>1.O g/day, severe glomerular sclerosis, moderate to severe tubelointerstitial lesions was 73.0%,82.3%and 76.0%respectively,and the average Ccr at renal biopsy was (59.15± 20.73) mL/min. All cases with a median followup of 18.5 months, 21 patients developed to ESRD. The incidence of intermediate to severe tubulointerstitial lesions and nephrotic-range proteinuria in group B was significantly higher than that in group A (84.9% vs 65.1%, P<O.05 and 41.5% vs 18.6%, P<O.05, respectively).Patients in B and A groups were followed-up for a median duration of 33 and 21 months,respectively, 28,0% and 14.0% patients reaching the endpoint. Conclusion: For patients with IgAN, the fundamental clinico-pathological features of chronic glomerulonephritis are as follows:①durative proteinuria>1.O g/day; ②lasting Ccr decrease; ③moderate to severe tubulointerstitial lesions accompanied with severe glomerular sclerosis. The three items mentioned above may be used as the early diagnostic criterion for chronic glomerulonephritis.%目的:探讨在原发性IgA肾病(IgAN)中如何早期作出慢性肾小球肾炎(慢性肾炎)的临床诊断.方法:于1993年3月-2009年8月我院肾活检

  15. A study on the clinico-pathological characteristics and expression of p53,PCNA in uterine borderline leiomyoma%交界性子宫平滑肌瘤临床病理特征及p53、PCNA表达的意义

    Institute of Scientific and Technical Information of China (English)

    李凯; 刘凤英

    2011-01-01

    目的:分析交界性子宫平滑肌瘤的临床病理特征及预后,检测p53、PCNA在其中的表达并探讨其意义.方法:回顾性分析57例交界性子宫平滑肌瘤患者临床病理特征并追踪;免疫组化S-P法检测其p53、PCNA表达,同时检测随机抽取10例正常子宫肌壁、20例子宫肌瘤、20例子宫肉瘤的p53、PCNA表达作为对照,分析二者在四组间表达的差异及意义.结果:交界性子宫平滑肌瘤临床表现无特异,病理上镜下可见核分裂象0~10个/5HPF,细胞一定异型性.预后好,可复发,多次复发后可恶变.肉瘤组p53阳性率、PCNA强阳性率高于肌瘤组和交界瘤组(P<0.05).交界性子宫肌瘤p53阳性组、PCNA强阳性组复发率高于阴性组及非强阳性组(P<0.05).结论:交界性子宫平滑肌瘤预后良好,未育者可考虑保留子宫,但多次复发后可恶变.术后无需化疗,应加强随访.p53阳性表达和PCNA强阳性表达与交界性子宫肌瘤的不良预后存在密切关系,可预测交界性子宫平滑肌瘤复发和恶变,为临床诊断、鉴别、判断预后及治疗提供指导.%Objective: To analyse clinico-pathological features and prognosis of uterine horderline leiomyoma and to study the expression and signification of protein p53 and PCNA in uterine borderline leiomyoma. Methods: The clinico pathological characteristics of 57cases with uterine bordline leiomyomas were analyzed retrospectively. S-P immunostaining was used to examine the expression of p53 and PCNA, while 10 cases normal myometrium tissue, 20 cases usual leiomyoma and 20 cases leiomyosarcoma were sampled randomly as the control group. The difference of protein p53 and PCNA expression among the four groups were assessed. Results: The symptoms of borderline leiomyoma were not obvious.In microscope, the mitotic figure was 0-10/5HPF, cell atypia was lighte. Borderline leiomyoma had good prognosis, but it could recur after operation. The expression of p53 and the strong

  16. [Acute posterior multifocal placoid pigment epitheliopathy. A rare cause of ischaemic stroke].

    Science.gov (United States)

    del Saz-Saucedo, Pablo; Alfaya-Muñoz, Laura Blanca; Recio-Bermejo, Marta; Lara-Medina, Francisco Javier; García-Chiclano, Amalia; Ortega-León, Teresa; Rueda-Medina, Ignacio; Domínguez-Fernández, María José; Madrid-Muñiz, Carmen; Franco-Huerta, María

    2013-06-01

    Introduccion. La epiteliopatia pigmentaria placoide multifocal posterior aguda (EPPMPA) es una enfermedad inflamatoria rara, generalmente de etiologia indeterminada, de la coriocapilar, el epitelio pigmentario y la retina externa. Afecta predominantemente a pacientes jovenes y en algunos casos puede involucrar al sistema nervioso central en forma de ictus o de meningoencefalitis. Presentamos el caso clinico de una mujer joven con EPPMPA complicada con ictus e hipertension intracraneal. Caso clinico. Mujer de 16 anos que comienza con cefalea intensa sugestiva de hipertension intracraneal, asi como con un deficit agudo hemisferico izquierdo. La resonancia magnetica craneal ponia de manifiesto lesiones embolicas o vasculiticas en diferentes territorios. No se evidenciaron datos de meningoencefalitis en el estudio del liquido cefalorraquideo, pero si de hipertension intracraneal asociada. La presencia de lesiones muy especificas en el polo ocular posterior permitio el diagnostico de EPPMPA complicada con ictus isquemico, probablemente por mecanismo vasculitico. Un amplio estudio etiologico fue negativo para identificar un factor desencadenante claro del proceso. Se inicio tratamiento corticoideo con buena evolucion clinica y radiologica. Conclusiones. La EPPMPA es una entidad rara que generalmente entrana buen pronostico; sin embargo, en algunos casos puede complicarse con afectacion del sistema nervioso central, y el ictus isquemico secundario a vasculitis es la complicacion mas grave. Ante un paciente joven con ictus que presente sintomatologia visual y lesiones coriorretinianas, debe considerarse la EPPMPA en su diagnostico etiologico.

  17. Quistes de los maxilares

    Directory of Open Access Journals (Sweden)

    Ivan Alberto Manotas Arevalo

    2013-12-01

    Full Text Available Los Grandes Quistes de los Maxilares han estado vinculados siempre a la humanidad, desde tiempos remotos, pues han sido halladas en restos de especimenes fosiles, han llamado la atencion de los clínicos, en torno a su etiologia, en la que se ha introducido la participacion de la genetica, (demostrada en el desarrollo de los queratoquistes maxilares, la fisiopatologia, caracteristicas histologicas (inmunohistoquimica, posibilidades diagnosticas por la imagen, (como la tomografia computarizada y la resonancia nuclear magnetica y otras pruebas. Además llaman la atención al estudio, por sus alternativas de manejo especialmente las formas radicales, y el analisis de asociaciones a otras patolo-gias benignas y malignas, y de la recurrencia muy alto de algunas de estas lesiones. Mucho se ha desarrollado para elucidar su naturaleza real, estadificar adecuadamente la lesion descartando asocia-ciones patologicas sindromicas, indicar un tratamiento apropiado, y realizar seguimientos a largo plazo. Este articulo pretende recaudar una information general que de parametros para abordar el estudio de los quistes maxilares a partir de la presentacion de un caso clinico.

  18. Delayed diagnosis is associated with changes in the clinical and ultrasound features of subcutaneous endometriosis near cesarean section scars.

    Science.gov (United States)

    Francica, G; Scarano, F

    2009-09-01

    Sommario INTRODUZIONE: Scopo dello studio è valutare le caratteristiche ecografiche e cliniche di endometriomi in prossimità di cicatrice di Pfannenstiel in rapporto a ritardo diagnostico segnalato da dimensioni ≥ 30 mm al momento della diagnosi istologica. METODI: Sono stati confrontati i dati clinico-anamnestici, ecografici e Color Doppler di 13 pazienti (età media 31.3 anni) con 13 endometriomi ≥ 30 mm (Ø medio 41.8 mm; range 30–60 mm) e di 17 pazienti (età media 30.7 anni) con 19 endometriomi morfologia ovalare, aree liquide interne, tramiti fistolosi e multipli poli vascolari con aumentata vascolarizzazione intralesionale. CONCLUSIONI: Il ritardo nella diagnosi dell'endometrioma su cicatrice di Pfannenstiel, segnalato da una storia clinica più lunga e complessa, modifica i caratteri ecostrutturali più tipici dell'endometrioma e può rendere ancora più difficile il riconoscimento di questa condizione patologica.

  19. Radiological pulmonary manifestations of acquired immunodeficiency syndrome; Manifestacoes radiologicas pulmonares da sindrome da imunodeficiencia adquirida

    Energy Technology Data Exchange (ETDEWEB)

    Marchiori, Edson; Melo, Alessandro Severo Alves de; Ossa, Alfonso Jaramillo [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia

    1999-06-01

    In this article are reviewed the principal radiologic manifestations of inflammatory and tumoral diseases the compromise the lungs of patients with acquired immunodeficiency syndrome. In the group of inflammatory diseases the radiologic aspects of pneumocystosis, cytomegalovirus disease, cryptococcosis, tuberculosis and bacterial pneumonias are emphasized. In the neoplasic diseases' group the aspects of lymphoma and Kaposi's sarcoma are specially presented. (author)

  20. Evolution of the radiological protection paradigms; Evolucao dos paradigmas de protecao radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Sordi, Gian Maria A.A. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Programa de Pos-Graduacao em Tecnologia Nuclear], E-mail: gmsordi@ipen.br

    2009-10-15

    We consider as initial radiological protection paradigms those in vigour after the release of the atomic energy for pacific usages in 1955. In that occasion, only one paradigm was introduced, presently named dose limitation system. After arguing about the basis that raised the paradigm, we introduced the guidance, that is, the measurements to be implemented to comply with the paradigm. In that occasion, they were two, i.e., the radiation dose monitoring and the workplace classification. Afterwards, the reasons that caused the radiological protection paradigms changes in force until 1995 are discussed. The initial paradigm was modified introducing the justification and the optimization principles, adding that the radiological protection should be economical and effective. The guidance also increased to four: personal monitoring, workplace classification, reference level and workers classification. Afterwards, we give the main justifications for the present paradigms that besides the formers were added the dose constraints, the potential exposure and the annual risk limits. Due to these modifications, the workers classifications were eliminated from the guidance, but the potential exposure and the search for the dose constraints were added. Eventually, we discuss the tendencies for the next future and the main changes introduced by the ICRP in the Publication 103, 2007. (author)

  1. Capacitation in radiological protection by internet; Formacion en proteccion radiologica via Internet

    Energy Technology Data Exchange (ETDEWEB)

    Pena, Juan J.; Vega, Jose Maria; Rossell, Maria Angeles; Calvo, Jose L. [Universidad de Extremadura, Badajoz (Spain). Hospital Universitario Infanta Cristina. Servicio de Radiofisica Hospitalaria y Proteccion Radiologica; Galvez, Manuel [Universidad de Cordoba (Spain). Facultad de Medicina. Servicio de Proteccion Radiologica

    2001-07-01

    This paper makes a proposal to use the Web for training Radiation Protection in Spanish/Portuguese languages. The Iberoamerican Group of Scientific Societies of Radioprotection (GRIAPRA) should take the lead of this educational project, to get in two years the following objectives: to prepare educational resources about Radioprotection in Spanish/Portuguese languages with the support of two Internet servers, one of them will be in Latin-American and the other in Spain; to talk over the methods for exchanging information between the teachers, tutors and students interested in participating in this project, to have a thorough knowledge of the activities and courses supported by the two internet servers; to set up agreements with Universities and professional Institutions related with Radioprotection in order that students, who get pass all the evaluations, exams and practical presential training organized in reference Centers previously selected, could obtain an academic accreditation. (author)

  2. Estimating radiological workload in operating robins; Estimacion de carga de trabajo radiologica en quirofanos

    Energy Technology Data Exchange (ETDEWEB)

    Rosales Espizua, F. J.; Maneru Camara, F.; Iriondo Igerabide, U.; Forner Forner, A.

    2011-07-01

    The study of the shielding necessary in operating rooms which are used in X-ray arcs requires a knowledge of workload that is usually difficult to estimate. The national and international recommendations in this regard reflect conditions of use radiological rooms, which is far from the real-time fluoroscopy in the operating room. A realistic estimate of the workload ja crucial, especially considering that the walls of These units are built with leas and leas aLtenuaLing materials. The work consists of a collection of workload in operating rooms that are carried out interventions.

  3. The radiological protection in the radiotherapy; La proteccion radiologica en la radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Castaneda M, A.; Gonzalez N, A. G. [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2010-09-15

    The cancer incidence in the world has been increased with the course of the time. Fifty percent of the patients receive radiotherapy, as much in the initial treatment, as in the recurrence cases or palliatives. At the moment is considered that in 1998 there were 2,500 teletherapy machines in operation in the countries in development and for the year 2015 will be necessary 10,000. In Mexico the use of these teletherapy units goes back to the year of 1956, when the effort of the Dr. Noriega Limon was consolidated with the installation of the first teletherapy unit with a cobalt 60 source in the National Medical Center of the IMSS. In the same decade the operation began of the Calibration Secondary Center located in the facilities of the General Hospital of Assistance and Health Secretary where a group of seven physicists began in the metrology techniques. Also the national authority in matter of the ionizing radiations use appears and promulgates the first Law in Nuclear Matter. The application has extended in the country, as well as other techniques that have gone incorporating for the cancer treatment. Such as: the brachytherapy, the stereo ataxia and the ophthalmic applicators. In the current application of the radiotherapy several factors are interrelated that have for objective that the dose to the workers and the public is as low as reasonably it can be achieved and that the patient receives the dose prescribed by the medical treatable in the organ or tissue and in the orderly quantity with the minor damage for the healthy tissues. To reach all this, it is necessary to have equipment s, systems, procedures, personal and standards that improve their quality in a gradual but firm way, also the good communication and comprehension among authorities are fundamental for this noble task. (Author)

  4. Radiation protection personnel training in Research Reactors; Capacitacion en proteccion radiologica para reactores de investigacion

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Carlos Dario; Lorenzo, Nestor Pedro de [Comision Nacional de Energia Atomica, Rio Negro (Argentina). Centro Atomico Bariloche. Instituto Balseiro

    1996-07-01

    The RA-6 research reactor is considering the main laboratory in the training of different groups related with radiological protection. The methodology applied to several courses over 15 years of experience is shown in this work. The reactor is also involved in the construction, design, start-up and sell of different installation outside Argentina for this reason several theoretical and practical courses had been developed. The acquired experience obtained is shown in this paper and the main purpose is to show the requirements to be taken into account for every group (subjects, goals, on-job training, etc) (author)

  5. Status of technical radiation protection units; Situacion de las Unidades Tecnicas de Proteccion Radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Arguelles Sanchez, R.; Rodriguez Marti, M.; Sierra Perler, I. C.; Villarroel Gonzalez-Elipe, R.

    2009-07-01

    The aim of this report is to analyse the current situation of Radiological Protection technical Units until December 2008 and to carry out an evaluation on the quality the services provided to clients in terms of nuclear safety and radiation protection at nuclear facilities and radioactive and medical radiodiagnostics facilities in accordance with the function assigned to them by the CSN. these are set forth in the Rules of Health Protection against ionising radiation and the RD 1976/1999 on quality criteria applied to radiodiagnostics. (Author)

  6. Design an online course of radiological protection; Diseno de un curso en linea de proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Garcia S, R.; Del Sol F, S.; Rivera M, T.; Sanchez G, D., E-mail: rigarcias@ipn.mx [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria No. 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico)

    2015-10-15

    Currently there is a vast research about the harmful effects of the use of ionizing radiation in medical procedures and in recent years struck by the rapid innovation in imaging equipment, considerably increasing the radiation dose received both patients and professionals in the radiodiagnosis area, service having the greatest demand in our country. The main strategy that has so far is education, that is, to inform all those involved in managing ionizing radiation about the applications and risks associated with them. Generally it requires that all personnel occupationally exposed attesting a course of radiation protection. However, the high demand for this type of medical services and poorly trained staff, makes taking a classroom course for personnel occupationally exposed is complicated. So that in the Instituto Politecnico Nacional (IPN) we are designing a course in radiation protection to be implemented online, through the virtual platform Moodle in a first stage, and a massive open online course as the second stage so that can be carried by anyone interested in the subject, without having to appear in person. This will allows to reach the largest possible number of personnel occupationally exposed to just have a computer with internet access. (Author)

  7. The regulation of the radiological protection in Mexico; La reglamentacion de la proteccion radiologica en Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Eibenschutz H, J. [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Jose Ma. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2008-12-15

    The regulation antecedents in nuclear question in Mexico are placed in 1950, with the promulgation of {sup L}aw that declares national mining reserves the uranium deposits, thorium and the other substances of which obtains fissionable isotopes that can produce nuclear energy{sup ,} instrument that stipulated the control of uranium, thorium, as to its it indicated it name, and other fissionable substances, on the part of the state, although they were without a doubt the respective institutions, the National Commission of Nuclear Energy in 1955, and the one of the National Commission of Nuclear Safety and Safeguards (CNSNS) in 1979, those that allowed the development of a prescribed frame in the nuclear and radiological areas. One characteristic of the regulation in radiological protection is the variety in the authorities type that have incidence in the regulation, as a result of the different approaches with which it can be approached. For example, in Mexico normative instruments with content in radiological protection exist and are watched over the Health Secretary, who is oriented to the protection of the patient, their relatives and the medical body; Work and Social Welfare Secretary, with a labor approach; Communications and Transport Secretary, which regulates the transport of nuclear and radioactive materials; Finance and Public Credit Secretary, who regulates the import and export of radioactive materials; Environment and Natural Resources Secretary, which regulates the environment protection; Energy Secretary who has responsibilities inside of the {sup p}rescribed law of article 27 constitutional in nuclear matter{sup ;} and within the energy sector, the CNSNS that expedite and watch the fulfillment of normative in radiological protection and nuclear safety. In order to resist effects of on regulation; frequently inter institutional agreements are carried out in which the areas of monitoring are agreed by each authority. The regulation in radiological protection demands the attention in all the involved subjects, like for example the patient protection. The prescribed experience in Mexico indicates that the involved authorities only must demand faculties for whose fulfillment they have all the necessary resources, or on the contrary to guarantee that it was counted on the same. Also it is necessary to understand that when there are overlap of functions in the regulation must need to be a complete coordination between the involved authorities. (Author)

  8. Training in radiological protection of residents; Formacion en proteccion radiologica de residentes

    Energy Technology Data Exchange (ETDEWEB)

    Vicent, M. D.; Fernandez, M. J.; Olmos, C.; Isidoro, B.; Espana, M. L.; Arranz, L.

    2013-06-01

    In compliance with the current laws, radiation protection (RP) training is required during the formative programs of certain Health Sciences specialties. Laws entrust to official bodies in specialized training the adoption of necessary measures to coordinate and ensure a correct implementation. The aim of this study is to describe Community of Madrid experience in RP training to specialists during their formative programs, and to determine the number of residents trained and analyze their satisfaction level with the training. A descriptive cross-sectional study was performed, including all training specialists from the Community of Madrid during the 2007-2011 period. We determined the number of residents trained per year and we evaluated their satisfaction level with the training through a survey. A total of 55 training courses were carried out and 5820 residents have been trained during the 2007-2011 period. the student satisfaction level with the training has increased gradually from 6.1 points in 2007 to 7.0 points in 2011. The development of the RP formative program for residents in the Community of Madrid has meant the start up o the necessary official mechanisms to ensure the quality and adequacy of training in this area, covering the formative needs of the collective. (Author) 10 refs.

  9. European reference standards on radiation protection training; Estandares de referencia europeos en formacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Llorente Herranz, C.; Marco Arboli, M.; Coeck, M.

    2011-07-01

    The PR is a very important challenge in applications of ionizing radiation (IR) in both industrial and medical and research. In Europe today we face a declining trend in the number of experts in PR for various reasons that may impact on maintaining a high level of competition in PR. This is essential to ensure future safe use of the Rl and the development of new technologies.

  10. Second level courses in radiation protection training; Cursos de segundo nivel de formacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Ribas, M.; Vanom, E.; Alonso, M.; Arranz, L.; Cordoba, D.; Ferrer, N.; Gomez, A.; Hernandez Armas, P.; Plallares, L.; Pombar, M. A.; Rubio, A.; Tellez de Cepeda, M.

    2011-07-01

    The aim of this paper is to present as being carried out the implementation of this standard in Spain by conducting specific courses, following the guide 116 of the Radiation Protection Commission, and the degree of acceptance of same among physicians who perform it.

  11. Blended learning specialists in radiation protection; Formacion semipresencial de especialistas en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Mayo, P.; Campayo, J. M.; Verdu, G.

    2011-07-01

    In this paper, we present a blended learning Radiation Protection Technician through an approved degree from the Polytechnic University of Valencia, which covers the knowledge and skills of functions relating to operators and supervisors in various areas and skilled workers to be to perform their work in technical units or Radiation Protection Radiation Protection Services. The benefits of this work are those related to achieving quality training flexible and adapted to follow the check off the person conducting the course, adapted to internal and external training of the applicant companies.

  12. Radiological Protection Plan an ethic responsibility; Plano de protecao radiologica e responsabilidade etica

    Energy Technology Data Exchange (ETDEWEB)

    Huhn, Andrea, E-mail: andrea.huhn@ifsc.edu.br [Instituto Federal de Santa Catarina (IFSC), Florianopolis, SC (Brazil); Vargas, Mara Ambrosina de Oliveira, E-mail: mara@ccs.ufs.br [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil)

    2014-07-01

    The Radiological Protection Plan - PPR, quoted by the Regulatory Standard 32, requires to be maintained at the workplace and at the disposal of the worker's inspection the PPR, for it to be aware of their work environment and the damage that can be caused by misuse of ionizing radiation. Objective: to discuss the interface between PPR and ethical reflection. Method: this is a reflective study. Discussion and results: regulatory norm 32 points out that the worker who conducts activities in areas where there are sources of ionizing radiation should know the risks associated with their work. However, it is considered that the sectors of hospital radiology the multidisciplinary health team is exposed to ionizing radiation and has not always aware of the harm caused by it, so end up unprotected conduct their activities. Concomitantly, recent studies emphasize the radiological protection and concern for the dangers of radiation on humans, but rather refer to the legislation about the radiological protection. In this context an ethical reflection is necessary, seeking to combine work ethics liability to care in protecting themselves and the other with the institutional conditions for this protection becomes effective.

  13. Radiological protection in the industrial area; La proteccion radiologica en el area industrial

    Energy Technology Data Exchange (ETDEWEB)

    Fraga, H. [Vicont, S. A. de C. V., Mexico D. F. (Mexico)

    2008-12-15

    Radiation protection (RP) in industrial applications is composed of four major themes that are recruiting and training personnel, equipment and instrumentation, materials used and also the acquisition of new technologies to improve their own RP. To carry out the recruitment of staff and train them to serve as occupationally exposed personnel in the industry continues with the Mexican Official Standard NOM-031-NUCL-1999, {sup R}equirements for qualification and training of personnel occupationally exposed to radiation ionizing{sup ,} what will be done regarding the physical fitness of personnel by NOM-026-NUCL-1999, {sup M}edical surveillance of personnel occupationally exposed to ionizing radiation{sup .} The principle of optimization of the RP, or ALARA principle (keeping the risk as low as reasonably achievable), is assumed to be the safety philosophy in the field of industrial applications of ionizing radiation. Practically all the elements that make up the equipment, instrumentation and materials used in industrial radiography and other industrial applications, has an orientation towards the protection, along with procedures that operate. For example, in industrial radiography the technician always has several instruments for radiation detection and measurement, some with visible and audible alarms. The equipment characteristics and transport (containers) are regulated by the standards NOM-025/1- 2000 and NOM-025/2-2996, which contains requirements for radiological safety in design and operation, respectively, for both as containers for some of its parts and accessories. As part of the technological innovation with benefits to the RP itself and eventually target practice today are venturing into the radiography digital, which involves the exposure of a plate image phosphorus-based with the later download to a computer. In combination with the use of sources of X-rays, there is a real contribution to reducing the dose, since the later are nowadays equipped with programmable controls, memory integrated wireless remote control and compact design and light weight. Also in the field of instrumentation for detection and measurement equipment is used to technological innovations such as storing a large number of readings and visible alarms, audible and vibrating. In the field of physical safety of radiation sources have been incorporated into devices such as video loops, motion sensors, electronic safety and emergency buttons installed according to the particular circumstances. (Author)

  14. Radiation protection requirements to dental clinics; Requisitos de protecao radiologica em clinicas odontologicas

    Energy Technology Data Exchange (ETDEWEB)

    Zenobio, Madelon A.F.; Silva, Teogenes Augusto da [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte, MG (Brazil)

    2002-07-01

    Diagnostic radiology consists of an ionizing radiation source to which the man are more exposed. The importance of radiographic exam in Dentistry made it a diagnostic supplemental resource and a treatment guide used by the dentistry area professionals. After studying all the risks related to X-ray on medical and odontological diagnostics, this study intends to realize a literature review in relation to the radiological protection requirements, among then, the article 453, that aim to promote the reduction of radiation doses to beings involved with diagnostic radiology without damaging or even improving the exam quality and the data on it included. (author)

  15. Environmental monitoring networks in Spain; Redes de vigilancia radiologica ambiental en Espana

    Energy Technology Data Exchange (ETDEWEB)

    Luque Heredia, S.; Martin Matarranz, J. L.; Marugan Tovar, I.; Rey del Castillo, C.; Salas Collantes, R.; Sterling Carmona, A.; Ramos Salvador, L. M.

    2011-07-01

    Environmental monitoring in Spain is carried out by several networks with different objectives and scope, a monitoring network in the vicinity of nuclear facilities and radioactive nuclear fuel cycle and various monitoring networks nationally funded and managed by agencies public. The aim of this paper is to present a summary of all monitoring networks, including a series of figures with the stations that are, their geographical distribution and the programs in them.

  16. Environmental radiological protection of Bariloche Atomic Center; Proteccion radiologica ambiental del Centro Atomico Bariloche

    Energy Technology Data Exchange (ETDEWEB)

    Andres, Pablo A.; Levanon, Izhar S., E-mail: andresp@cab.cnea.gov.ar, E-mail: levanon@cab.cnca.gov.ar [Comision Nacional de Energia Atomica (CNEA), San Carlos de Bariloche (Argentina). Centro Atomico Bariloche. Division Proteccion Radiologica

    2013-07-01

    This plan of monitoring radiological environmental routine fits on environmental policy of CNEA, satisfying national and international recommendations for licensed facilities. Sampling matrices are related to direct routes of exposure: air and water (river, lake, sediments, drinking water). Soil samples are also analyzed for having integrated matrices. They are considered as minimum three points of measurement: a white point (water or winds up), a point of maximum (water or winds down) and a point corresponding to the location of the individual representative or a point of public interest. Measurements in air estimate KERMA rate with thermoluminescent dosimeters, bi-monthly, and concentrations of particulate material and aerosols. For water samples (monthly), soil and sediments (quarterly), radionuclides that have download limits are analyzed, according to its importance in the dosages produced in the representative individual. In these cases artificial radionuclides using gamma spectrometry, beta total and Sr-90 by radiochemical techniques if the value of total screening (1 Bq/L) is exceeded. Foods are not included because no possible matrices were detected, either by their distance. by located not predominant wind direction. They are however still looking for milk producers that fulfills the minimum requirements.The data collected are compared with environmental baselines to set trends that might point to future significant changes in the environment during the life of the facilities. So far it was not observed significant differences with respect to baseline values.

  17. Review of the general regulation of radiological protection; Revision del reglamento general de seguridad radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Cortes C, A. [Comision Nacional de Seguridad Nuclear y Salvaguardias, Area de Impacto Radiologico y Emergencias, Dr. Jose Ma. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2008-12-15

    As a result of advances in radiation protection at the international level, the National Commission of Nuclear Safety and Safeguards has been given the task of revising the General Regulation of Radiation Safety to cover such developments, especially those contained in the safety basic standards No. 115 of the IAEA, published in 1977. In addition, the working group has considered issues that need to be regulated to avoid unnecessary dose received by the public due to exposure to ionizing radiation. Related to the public exposure believes the preliminary deal with situations of chronic exposure in homes, as well as human activities involving natural sources of ionizing radiation exposure to cause the public to levels that exceed the dose limits laid down in the Regulation. It is also envisaged that they will be subject to monitoring by the Commission, the concentration levels due to radon in homes, radon outdoor, radio and radon in drinking water, and external radiation levels due to naturally occurring radionuclides in building materials. Thus, the processes that may be subject to surveillance by the National Commission of Nuclear Safety and Safeguards include water treatment, some metallurgical processes, some of the mining industry and some industrial processes in which waste increase activity concentration of naturally occurring radionuclides. With the revision of the General Regulation of Radiation Safety, certain standards must be reviewed and further developed such as the concentration of radon levels in homes room, outdoor radon, radon and radio in drinking water, radiation levels out sourcing due to naturally occurring radionuclides in building materials, and standards governing (and identify) the radioactive material generation in the processes mentioned previously. (Author)

  18. Radiologic protection in intensive therapy units; Protecao radiologica em unidades de terapia intensiva

    Energy Technology Data Exchange (ETDEWEB)

    Andrea, H.; Juliana, C.; Gerusa, R.; Laurete, M.B.; Suelen, S., E-mail: andrea.huhn@ifsc.edu.br, E-mail: juliana@ifsc.edu.br, E-mail: gerusa@ifsc.edu.br, E-mail: laurete@ifsc.edu.br, E-mail: suelen.saraiva@ifsc.edu.br [Instituto Federal de Santa Catarina (IFSC), Florianopolis, SC (Brazil); Derech, Rodrigo D.A., E-mail: dagostiniderech@gmail.com [Policlinica Municipal Sul, Florianopolis, SC (Brazil)

    2013-11-01

    The discovery of X-ray was a great achievement for humanity, especially for the medical community. In Intensive Care Units (ICUs), the RX tests, performed with mobile devices, add immense value to the diagnosis of inpatients who do not have the option to carry them out of bed. Following the technology and its improvements, fatalities arose from misuse of ionizing radiation, which mostly gave up for lack of knowledge of the biological effects caused by them, which leads to fear among professionals and often prevents a quick job and effectively by professionals of radiological techniques. The research it is a systematic review of the literature and justified by the scarcity of materials that reflect on the radiological protection in ICUs. For this study we found the Virtual Health Library (VHL) and Pubmed were indexed terms radiological protection and intensive care units, the search in Portuguese and English terms were used radiological protection and intensive care unit. The study aims to inform professionals of ICUs on the main aspects that refer to X-rays in hospital beds, the standards of radiological protection and personal protective equipment, thus avoiding possible damage to the biological health of workers, addressing subjects in rules and laws about the X radiation, emphasizing the protection of professionals in intensive care. It is clear, finally, that little research is conducted in the context of radiological protection of workers ICU's and this is a place that receives daily RX equipment, deserving more attention to protect the worker. (author)

  19. Medical intervention in radiological emergencies, formation and training; Intervencion medica en emergencias radiologicas, formacion y adiestramiento

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas H, J. [CPHR, Calle 20 No. 4113, e/41 y 47 Playa, CP 11300, La Habana (Cuba)]. e-mail: cardenas@cphr.edu.cu

    2006-07-01

    The work exposes the national experience in the development of training programs in medical aspects of the radiological emergencies. Implemented after valuing the existent situation, identified the necessities and the reach of the training, additionally it was elaborated the content of the training program whose purpose is guided to the invigoration of the medical answer capacity in radiological emergencies The content of the modular program it approaches theoretical- practical aspects on preparation and medical answer in radiological emergencies. The program includes an exercise that simulates a radiological accident, to evaluate during the same one, the answer capacity before this situation. The training concludes with the design of a strategy for the preparation and answer in radiological emergencies in correspondence with the potential accidental scenarios that the participants can face. (Author)

  20. Radiation protection in medical centers : teletherapy service; Proteccion radiologica en centros hospitalarios : servicio de teleterapia

    Energy Technology Data Exchange (ETDEWEB)

    Resendiz G, G.; Perez P, M.; Figueroa M, E. [Clinica Medica Sur, Servicio de Radioterapia, Puente de Piedra No. 150, Col. Toriello Guerra, Mexico 14050 D. F. (Mexico)

    2008-12-15

    The General Regulation of Radiation Safety, it clearly provides the classification, requirements and obligations of the various figures relating to a radiation protection system, i.e., the occupationally exposed personnel, the radiation safety responsible, the legal representative, the type of installation, etc. For new installations, the shieldings calculation should be contained in the analytical report with due consideration of factors, such as those surrounding the areas classification based on the occupation type, the work load of the equipment and others. The operation license involves requirements such as the Report and the Radiation Safety Handbook, the Emergencies Plan, the establishment of register levels, investigation and intervention, the way it is carried out medical surveillance of the occupationally exposed personnel, and the description of the protection mechanisms and detection instrumentation and radiation measurement. Deserves mention the case when high readings are recorded in the personal dosimeters, which must submit to an interrogation to the employee, you must determine if it is an incorrect reading to the service provider, you must perform a medical exam blood cell count with relevant to the dose determination, may eventually can lead to a cytogenetic study and the determination to do if confirmed an unexpectedly high dose. Moreover, the technology evolution also implies the development of adaptation measures. For example, the Intensity Modulated Radiation Therapy, which is an advanced high-precision radiotherapy that uses X-ray accelerators for computer-controlled radiation doses precisely to a malignant tumor or specific areas within the tumor, taking into account requires regard to equipment, and space and shielding, time and staff hours for treatment, personnel training, materials for making images (such as two-dimensional arrangements of integrated circuits or diodes, films or portal images), the attention given by the engineers of service, the validation of the treatment plan and quality control of the planning system and dosimetry parameters and mechanics. (Author)

  1. Biological dosimetry in radiological emergency; Dosimetria biologica en situacion de emergencia radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; Arceo M, C. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)], e-mail: citlali.guerrero@inin.gob.mx

    2009-10-15

    When accidents occur where large numbers of people are exposed to high doses of ionizing radiation is necessary to take urgent decisions regarding the appropriate treatment that is required. In this regard, chromosome analysis can provide additional information to that obtained from clinical observations confirming cases that had serious partial exposure and discriminating at same time to the false positives attributable to previous infections or to hysterical behaviour. Ionizing radiation causes various types of aberrations in chromosomes but one of the most characteristics is the dicentric. The analysis of these in lymphocytes is a good indicator of level exposure, in addition to be of easy examination, the basal frequency on the population is low (1 x 10{sup 3} cells) and increases in proportion to dose. To set the exposure dose is usually required to analyze 1000 cells, a procedure that in emergencies is very slow because it requires quick decisions to apply the adequate treatment to patient. For that reason when occurred the nuclear accident in Chernobyl, was established a criterion of quick analysis test based on examination of 50 metaphases for each case. To corroborate the validity of an alternative criterion (50 metaphases or 30 dicentrics), later in year 2000 was simulated in laboratory one accident exposing peripheral blood lymphocytes in whole or in part within a range of 0-8 Gy of gamma radiation. As part of activities of Regional Project IAEA - RLA/9/054 (strengthening of national systems for preparedness and response in radiological and nuclear emergencies) the seven participating countries made and inter calibration exercise for the dicentrics analysis and corresponding dose estimated, parallel, decided to estimate the dose from analysis of 25, 50, 100 or 500 metaphases and thus sets the minimum number that should be examined for reliable results. The results of inter calibration exercise agree with those previously published in 2000, indicate that the analysis of 50 metaphases, regardless of the dicentrics number there is enough to separate the overexposure cases of non radio exposed, and the first results placed in a dose category. (Author)

  2. Radiological evidences from emphysematous cholecystitis. Manifestaciones radiologicas de la colecistitis enfisematosas

    Energy Technology Data Exchange (ETDEWEB)

    Martin Garcia, V.; Ganado Diaz, T.; Cabeza Martinez, B.; Montoro Martos, E.; Contreras Cecilia, E. (Hospital Clinico Universitario ' ' San Carlos' ' . Servicio de Radiodiagnostico. Madrid (Spain))

    1993-05-01

    Emphysematous cholecystitits is an uncommon clinical disorder, the diagnosis of which is based on the demonstration of the presence of gas in the vesicular wall and/or lumen. We present 9 cases studied by means of simple radiography, ultrasonography and abdominal CT scan. The diagnosis was based in every case on imaging methods and was confirmed surgically. (Author)

  3. Operational Radiation Protection in veterinary centres; Proteccion Radiologica Operacional en centros veterinarios

    Energy Technology Data Exchange (ETDEWEB)

    Cordon, E.; Vigil, A.; Coll, A.

    2012-07-01

    Nowadays, there is a trend towards the use of digital radiography in the veterinary field. As a consequence, there could be a workload increase in the X-ray system and higher exposure for veterinarians and members of the public. In this study we analyze the influence of the X-ray machine output with with the radiation levels at the veterinarian position. We have considered the leads apron that each veterinarian center has and we have related its attenuation coefficient with the dose exposure at the veterinarian position. With the maximum workload, we have made a theoretical assessment for the primary barrier at 1 m of the X-ray focus.Despite there is a workload increase due to the digital technologies, the studied results show that is is very unlikely to be in excess of annual dose limit for the exposed workers. (Author) 5 refs.

  4. Knowledge plus Attitude in Radiation Protection; Aptitud mas Actitud en Proteccion Radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Velez, G. R.; Sanchez, G. D.

    2003-07-01

    Since the introduction of the Basic Safety Standards recommendations, the scope of the radiation protection was broadening. On behalf of the incorporation of radiation protection of the patient in medical exposures, the different groups of professionals involved: physicians, medical physicists, radiation protection officers, regulators, etc., have to work together. The objective of radiation protection, that is, to reduces doses from practices, to prevent potential exposures, to detect its occurrence as well as to evaluate and spread such abnormal situations, will be obtained only if it were possible to joint two basic conditions: knowledge and attitude. It should be well known the differences between the backgrounds needed to be for example, a medical physicist or an R.P.O., However, their attitude to solve an eventual problem involving radiation protection should be the same; as well as the behavior of the specialized physician and regulators, in order to add towards common goals. In this work, we show as an example the curricula contents about radiation protection of the cancer of medical physics in the Universidad Nacional de San Martin (UNSAM), and the corresponding module on medical exposures from the Post-Graduate course on Radiation Protection and Nuclear Safety, held since the 80s in Buenos Aires by the National Commission of Atomic Energy, ARN, IAEA, and the Universidad de Buenos Aires. On the other hand, we describe different attitudes which leads or could start major radiological accidents, regardless the level of knowledge in radiation protection. We conclude that the larger numbers of accidents are due to problems in the attitude than in the level of knowledge of the person involved. Consequently; we suggest emphasizing the discussion on how to generate positive attitudes in every professional involucrated, independently of its cognitive profile or level. (Author) 2 refs.

  5. Radiological protection in nuclear power plants; La proteccion radiologica en las centrales nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Zorrilla R, S. [CFE. Central Laguna Verde, Km. 42.5 Carretera Cardel-Nautla, Veracruz (Mexico)

    2008-12-15

    This presentation sharing experiences which correspond to the nuclear power plant of Laguna Verde. This nuclear power plant is located at level 2 of four possible, in the classification performance of the World Association of Nuclear Operators (WANO), which means the mexican nuclear power plant is classified in terms of its performance indicators and above the average achieved by their counterparts americans and canadians. In the national context, the nuclear power plant of Laguna Verde has also been honored with several awards such as the National Quality Award, the Clean Industry Certificate, the distinction of Environmental Excellence and others of similar importance. For the standards of WANO, the basic idea is that there are shortcomings in one of nuclear power plant concern to all partners. The indicators used for the classification will always go beyond more compliance with regulations, which are assumed, and rather assume come or a path to excellence. Among the most important indicators are: the collective dose, the percentage of areas declared as contaminated, the number, type and tendency of contamination personal cases, the number of dosimetry alarms, the number of unplanned exposures, loss control of high radiation areas and the release of contaminated material outside the restricted areas. Furthermore, as already indicated, nuclear power plants are of special care situations, such as, carrying out work in areas with radiation fields of more than 15 mSv h{sup -1}, the movement of spent fuel in the reload floor. The consideration of the minimum total effective dose equivalent as a criterion for prescribing tools that reduce exposures, but may increase the external cases of contaminated casualties, the experience in portals such as workers subject to radiology, where exposure in industrial radiography, and so on. Special mention deserve the conditions generated during fuel reload stops, which causes a massive personnel movement, working simultaneously on several fronts, the number of dosimetry transactions, increases up to 30 times the normal operation, and so on. For these reasons during the reloads, the electronic dosimetry system and the monitoring system output contamination staff becomes critical systems whose functioning must be ensured to avoid becoming a bottleneck. Reloads must also be planned for a perfect manning of critical supplies such as clothing and protection accessories against contamination. (Author)

  6. Radiation protection in medical applications; La proteccion radiologica en las aplicaciones medicas

    Energy Technology Data Exchange (ETDEWEB)

    Maldonado M, H. [Sociedad Mexicana de Seguridad Radiologica A. C., Mexico D. F. (Mexico)

    2008-12-15

    The justification of the practices is the fundamental principle on which rests the peaceful use of ionizing radiations. They actually contain as aspirations to improve the quality of people's lives, contributing to sustainable development through environmental protection, so that the sources security and the individuals protection will be conditions which are not and should can not be operated. For medical applications is a highly illustrative example of this, since both for the diagnosis and therapy, the goal is to achieve what is sought for the white tissue, secured the least possible damage to the neighboring tissues so that in turn reduce the negative effects for the patient. As a basis for achieving the above, it is essential to have qualified personnel in all areas incidents, for example users, workers, officials and staff members. There are a variety of specialists in the field of medical applications as, nuclear chemistry, nuclear engineering, radiation protection, medical physics, radiation physics and others. Among the human resource in the country must make up the majority are medical radiologists, highlighting gaps in the number of radiotherapy and nuclear medicine but specially in the medical physics, who is in some way from a special viewpoint of the formal school, new to the country. This is true for the number of facilities which are in the country. The radiation protection responsibilities in medical applications focus primarily on two figures: the radiology safety manager, who is primarily dedicated to the protection of occupationally exposed personnel and the public, and the medical physicist whose functions are geared towards the radiological protection of the patient. The principal legislation in the medical applications area has been enacted and is monitored by the Health Secretary and National Commission on Nuclear Safety and Safeguards, entities that have reached agreements to avoid overlap and over-regulation. Medical applications in the country wish to fulfill the commitment to meet the current needs in medicine, with a favorable balance of benefits and achieving excellence in harnessing of the atom energy. (Author)

  7. Characteristics of radiation protection legislation; Caracteristicas de la legislacion en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Puig Cardozo, Diva E. [Ministerio de Industria, Energia y Mineria (MIEM), Montevideo (Uruguay). Direccion Nacional de Tecnologia Nuclear

    2001-07-01

    The laws on radiological protection have special characteristics. They can exist laws that regulate dangerous activities that will be also applicable, if it corresponds to the activities that involve radioactive materials. But a law of radiological protection should exist. It foresees the existence of an appropriate regulatory body and specialized institutions, definitions, infractions and sanctions then the respective regulations will be elaborated for the different applications. The objective is to contribute to the development of the nuclear energy in the country and to provide the regulatory basis that assures a reasonable security for radioactive installations. The essential objectives of these laws are: 1. to establish the legislative framework for the development and employment of nuclear energy, without risks, according with treaties and conventions that the countries have approved. 2. To fix the fundamental principles and the conditions of their setting in practice allowing to a specific regulation determining application procedures. 3. To create a structure of regulation of enough authority to be able to control and to watch over in an effective way the authorized activities 4. To guarantee an appropriate financial protection against the derived damages of accidents or nuclear incidents. (author)

  8. Services and technical units for radiological protection; Servicios y unidades tecnicas de proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    Spanish law establishes the standard concerning ionizing radiation in accordance to European Union directives. the Spanish NSC (CSN) is the regulatory body in matters of radiological safety which issues a perceptive report on work conditions in everything related to radiological protection of nuclear and radioactive installations. It also inspects and approves their action protocols and makes demands that certain entities employ additional support with respect to radiological protection which they can receive through calls for radiological protection services and technical units. This article takes a look at what these services and technical units are and how they act. (Author)

  9. Radiation protection in medical and biomedical research; Proteccion radiologica en la investigacion medica y biomedica

    Energy Technology Data Exchange (ETDEWEB)

    Fuente Puch, A.E. de la, E-mail: andres@orasen.co.cuES [Centro Nacional de Seguridad Nuclear, La Habana (Cuba)

    2013-11-01

    The human exposure to ionizing radiation in the context of medical and biomedical research raises specific ethical challenges whose resolution approaches should be based on scientific, legal and procedural matters. Joint Resolution MINSAP CITMA-Regulation 'Basic Standards of Radiation Safety' of 30 November 2001 (hereafter NBS) provides for the first time in Cuba legislation specifically designed to protect patients and healthy people who participate in research programs medical and biomedical and exposed to radiation. The objective of this paper is to demonstrate the need to develop specific requirements for radiation protection in medical and biomedical research, as well as to identify all the institutions involved in this in order to establish the necessary cooperation to ensure the protection of persons participating in the investigation.

  10. Radiation protection in large linear accelerators; Seguranca radiologica de aceleradores lineares de grande porte

    Energy Technology Data Exchange (ETDEWEB)

    Oliva, Jose de Jesus Rivero, E-mail: rivero@con.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Departamento de Engenharia Nuclear; Sousa, Fernando Nuno Carneiro de, E-mail: fernandonunosousa@gmail.com [Aceletron Irradiacao lndustrial, Rio de Janeiro, RJ (Brazil)

    2013-07-01

    The electron linear accelerators can be used in industrial applications that require powerful sources of ionizing radiation. They have the important characteristic of not representing a radiation hazard when the accelerators remain electrically disconnected. With the plant in operation, a high reliability defense in depth reduces the risk of radiological accidents to extremely small levels. It is practically impossible that a person could enter into the radiation bunker with the accelerators connected. Aceletron Irradiacao Industrial, located in Rio de Janeiro, offers services of irradiation by means of two powerful electron linear accelerators, with 15 kW power and 10 MeV electron energy. Despite the high level of existing radiation safety, a simplified risk study is underway to identify possible sequences of radiological accidents. The study is based on the combined application of the event and fault trees techniques. Preliminary results confirm that there is a very small risk of entering into the irradiation bunker with the accelerators in operation, but the risk of an operator entering into the bunker during a process interruption and remaining there without notice after the accelerators were restarted may be considerably larger. Based on these results the Company is considering alternatives to reduce the likelihood of human error of this type that could lead to a radiological accident. The paper describes the defense in depth of the irradiation process in Aceletron Irradiacao Industrial, as well as the models and preliminary results of the ongoing risk analysis, including the additional safety measures which are being evaluated. (author)

  11. Radiological materials management from dismantling; Gestion Radiologica de materiales en Desmantelamiento

    Energy Technology Data Exchange (ETDEWEB)

    Ondarro, M.; Ortiz, M. T.; Irun, I.; Just, J.

    2001-07-01

    One of the problems involved in the performance of Nuclear Power Plant Dismantling tasks is the management of the materials from the point of view Radiological Control aspects arising during performance of the Project, regardless of whether they are: 1) Conventional materials, 2) Declassificable materials, 3) Declassified materials, and 4) Radioactive wastes. In particular, another objective to be achieved in the Vandellos-1 NPP (CV-V1) Decommissioning and Dismantling Plan, now in advanced performance activities, is the release or exoneration from regulatory controls of the largest possible number of materials, equipment, system, buildings and terrain subjected to such Regulatory Controls. In order to achieve this objective, there is a need for contrasted equipment designed to achieve this release from regulatory control and providing adequate levels of data guarantee and protection. Also, there is a summary of the different volumes of materials to be managed, by streams, resulting from the initial studies performed during the preliminary Project. To guarantee that, the materials are adequately managed (Radiological Control), clearly separating those which are contaminated from those which are not. The quantities to be managed and the mechanisms applied are described, and the different techniques from those which are not. The quantities to be managed and the mechanisms applied are described, and the different techniques used to ensure compliance with the derived values are dealt with. Likewise, the paper describes the difficulties encountered during the process of preparing the documentation submitted to the CSN for issuing of the Declassification permit. The process of drawing up this documentation and its submittal to the Regulatory Authority is also dealt with briefly. The paper includes a description of the different measuring equipment and techniques used at the CNV-1 site to meet the declassification requirements imposed by the regulatory authority (Nuclear Safety Council-CSN). Finally, major conclusions are summarized in order to be taking in account in other activities. (Author)

  12. Basic concepts on environmental radiation protection; Conceitos basicos de protecao radiologica ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Rochedo, Elaine R.R.; Amaral, Eliana C.S

    2007-07-01

    This chapter makes an overview on basic concepts of environmental radiation protection, approaching the system of protection for practices, evaluation oc the environmental radiologic impact, environmental monitoring, models and exposures pathways.

  13. Urinary Derivations: Radiological Anatomy and Complications; Derivaciones urinarias: anatomia radiologica y complicaciones

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, A.; Escartin, I.; Zapater, C.; Riazuelo, G.; Canon, R.; Solanas, S.; Garcia de Jalon, A. [Hospital Universitarion Miguel Servet. Zaragoza (Spain)

    2003-07-01

    Cystectomy with urine derivation is a common procedure in the treatment of transition cell carcinoma of the bladder. We present radiological findings (ultrasound scan, computerized tomography (CT) and urography) from the surgical reconstruction techniques most often performed by the Urology staff of our hospital as well as some of the complications which occur. The above-mentioned techniques are basically divided into two types: incontinent derivations, of which we highlight the Bicker-Wallace technique and continent ones. The latter can either be ortho topic, with urethral anastomosis (Hauptmann's technique), or heterotopic, with urine excretion through the anus (Mains II technique) or employing a self-catheter (Mainz I technique). (Author) 7 refs.

  14. The nuclear and radiological regulation in Mexico; La regulacion nuclear y radiologica en Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Carreno P, A. L.; Cuecuecha J, M. E., E-mail: alcarreno@cnsns.gob.mx [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2012-10-15

    The regulation in nuclear and radiological safety matter in Mexico is in constant development, attended the workers necessities, the society and the environment. The present work exposes and gives to know the process to emit a Mexican Official Standard of the Nucl series, also enunciates the dependences and institutions that participate in the process, the main identified challenges for its elaboration, emission and revision, and finally are mentioned the topics that in the present are in this process. (Author)

  15. History of the radiological protection in Mexico; Historia de la proteccion radiologica en Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz M, J. R. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2008-12-15

    The beginning in the use of the ionizing radiations goes back towards end of 19 century, when Wilhelm Roentgen discovers x-rays in 1985, finding that quickly founds also the new technology, which spreads to tabs of multiple applications anywhere in the world, some of very beneficial them of use like the radio diagnosis, but others of frivolous and commercial kind. As much in the beneficial uses as in the banal ones, the world also is begun to be aware that the ionizing radiations are a physical element that must be handled with precaution then also can induce injuries in the involved people, which is documented already in 1912. This characteristic is confirmed with the use of Radio-226 as source of ionizing radiation, in whose applications were observed some deleterious effects, which forces to take some measures of protection an intuitive and rather incipient way. The first attempt of limit was denominated erythema dose, that it was a concept of qualitative-subjective character when it is observed a reddening of the skin of the radiated zone. Just a short time later, with the invention of the detector Geiger and the possibility of measuring the radiation quantity received by the people, the limits are transformed into quantitative. lt is as well as it is born the radiological protection like scientific and technological discipline, and essential ally of the nuclear energy pacific applications , event in which the international organizations related to the subject play a very important role, in the middle of the 1920 decade. Since then radiological protection (RP) is in permanent evolution, keeping a balance between the people protection, the sources security and the benefits of the ionizing radiations applications. In Mexico, the nuclear energy taking height from the second half of 1950, when the National Commission of Nuclear Energy was created, it spent in his first years to functions that mainly were of investigation, but in which already appeared the RP like one of its fundamental programs, along with others of similar importance like those of radioactive precipitation measurement. lt was the own National Commission of Nuclear Energy the one that begins the development of certain functions of regulating character. With the birth of the project of the Nuclear Power Plant of Laguna Verde, in the middle of the 1970 decade, the radiological protection in Mexico acquires and additional relevance from different perspective: on the one hand the necessity of the inclusion of a dedicated organization of radiological protection as much of the workers, as if to inhabitants of the zones bordering the nuclear plant. On 1979 it is created the National Commission of Nuclear Safety and Safeguards like exclusively regulating organization in the nuclear and radiological field, which constitutes a landmark in the modern history of the RP in Mexico. The own constant evolution in the RP concepts demands the preparation to confront the new future challenges. (Author)

  16. Research and development in radiological protection; Investigacion y desarrollo en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Butragueno, J. L.; Villota, C.; Gutierrez, C.; Rodriguez, A.

    2004-07-01

    The objective of Radiological Protection is to gurantee that neither people, be they workers or members of the public, or the environment are exposed to radiological risks considered by society to be unacceptable. Among the various resources available to meet this objective is Research and Development (R and D), which is carried out in three areas: I. Radiological protection of persons: (a) knowledge of the biological effects of radiations, in order to determine the relationship that exists between radiation exposure dose and its effects on health; (b) the development of new personal dosimetry techniques in order to adapt to new situations, instrumental techniques and information managmenet technologies allowing for better assessment of exposure dose; and (c) development of the principle of radiological protection optimisation (ALARA), which has been set up internationally as the fundamental principle on which radiological protection interventions are based. II. Assessment of environmental radiological impact, the objective of which is to assess the nature and magnitude of situations of exposure to ionising radiations as a result of the controlled or uncontrolled release of radioactive material to the environment, and III.Reduction of the radiological impact of radioactive wastes, the objective of which is to develop radioactive material and waste management techniques suitable for each situation, in order to reduce the risks assocaited with their definitive managmenet or thier release to the environment. Briefly desribed below are the strategic lines of R and D of the CSN, the Electricity Industry, Ciemat and Enresa in the aforementioned areas. (Author)

  17. Clinico-epidemiologicalfeatures of dengue fever in Saudi Arabia

    Institute of Scientific and Technical Information of China (English)

    Abdel-Hady El-Gilany; Abdelaziz Eldeib; Sabri Hammad

    2010-01-01

    Objective: To highlight some clinical and epidemiological features of dengue fever.Methods:All patients who were admitted to hospitals in Holly Mecca City, Saudi Arabia and were confirmed as dengue fever (DF) or dengue hemorrhagic fever (DHF) were included in this study. The data were collected from patient files and through direct interview with patients or their relatives. Cases were followed through their hospital stay. Routine laboratory investigations were done and diagnosis was confirmed by PCR.Results: Most of cases admitted in stable condition (94.37%) and only one case (1.41%) died. Dengue-1 and 3 types were the prevalent dengue viruses and cases in age group 16-44 were the most frequent (70.40%). The most common symptoms was fever reported from all cases followed by headache (74.60%), myalgia and anorexia (67.60%), back pain (59.20%) and chills (54.90%). DF represented (60.57%) of the cases while DHF represented (39.43%). About half of cases had underground water tanks for human use, 5.60% had over house roof water tanks and 43.70% had both types, 16.90% of these tanks were uncovered. Approximately 70.00% of cases reported presence of small collection of water nearby houses and 46.80% reported the presence of mosquitoes within their houses.Conclusions: Most dengue fever cases might be endogenous in origin due to prevalence of mosquitoes and their breeding places within the houses and in nearby localities. Control of mosquitoes and their breeding places will contribute to prevention of dengue fever.

  18. Clinico-etiologic correlates of onychomycosis in Sikkim

    Directory of Open Access Journals (Sweden)

    Adhikari Luna

    2009-04-01

    Full Text Available Aims and objectives: The etiological spectrum of any superficial mycosis is largely dependent on the flora in the immediate environment of the individual. It is influenced by the geographic, climatic and occupational factors. The study is basically to formulate baseline data for the species prevalence of various dermatophytes in patients with onychomycosis attending the Central Referral Hospital, Gangtok, Sikkim. Materials and Methods: Thirty-four clinically suspected cases of onychomycosis were subjected to mycological studies. Results: Thirty-two (94.12% cases were positive for fungal elements by direct microscopy and 28 (82.35% by culture. Young adults in the age group of 21-30 years were mainly affected. The male:female ratio was 1.125:1. Dermatophytes were isolated in 18 cases (64.29%. Trichophyton tonsurans (44.44% was the most common isolate followed by T. mentagrophytes (22.22%, T. rubrum (11.11%, T. verrucosum (11.11% and Microsporum audouinii (11.11%. Apart from dermatophytes, Aspergillus niger (21.43% and Penicillium marneffei (14.28% were also isolated. Conclusion: Dermatophytes, mainly T. tonsurans, as well as moulds other than dermatophytes were isolated from onychomycosis patients in Gangtok, Sikkim.

  19. Angina monocitica con sovrainfezione da Prevotella denticola: caso clinico

    Directory of Open Access Journals (Sweden)

    Maria Teresa Allù

    2005-06-01

    Full Text Available Monocytic angina with superinfection of Prevotella denticola: clinical case Monocytic angina is a clinical sindrome caused by Epstein-Barr virus characterized by fever, pharyngitis, exudative tonsillitis, swollen lymphoglands, splenomegaly and hepatomegaly.The inflamed pharynx and necrotic tonsils of infectious mononucleosis are subject to bacterial superinfection initially or during the course of the illness; the reduced PO2 tension and low oxidation-reduction potential that prevail in a vascular and necrotic tissues favour the growth of anaerobes. In this article we reported the clinical case of a ten years old children, who presented fever and tonsillopharyngitis; he was treated with cefotaxime and piperacillin, he did not improve in health. He was admitted to hospital (Department of Otorhinolaryngology. The patient was treated with aminoglycoside (tobramycin, piperacillin and cortisone; the clinical situation deteriorated. Pus sample was collected from the tonsils and cultured. Isolated strain from culture anaerobic was identified biochemically (Rapid-ID32ANA.The microorganism isolated was: Prevotella denticola (oral anaerobic gram-negative rods; β-lactamase production was tested by using the chromogenic cephalosporin disk test.The susceptibility to antibiotics was performed according to NCCLS recommendations. Prevotella denticola (β-lactamase production was resistant to penicillin, cefoxitin, cefotetan, piperacillin, clindamycin and metronidazole it was susceptible to piperacillin-tazobactam, amoxicillin-clavulanate, ticarcillin-clavulanate, imipenem and chloramphenicol. Children was treated with piperacillin-tazobactam, with rapid symptomatic relief.

  20. Lipodistrofia ginoide : aspectos epidemiologicos clinicos histopatologicos e terapeuticos

    OpenAIRE

    Ana Beatris Rodrigues Rossi

    1996-01-01

    Resumo: Com os objetivos de estudar os aspectos clínicos, epidemiológicos e histopatológicos (derme) da lipodistrofia ginóide (L.D.G.) e avaliar a eficácia da terapêutica tópica, foi realizado um estudo observacional descritivo de um grupo de 75 mulheres, que participaram de um ensaio clínico duplo cego - placebo com um produto tópico. Como princípios ativos, foram empregados um vaso ativo (ginkgo biloba), um lipolítico (cafeína) e um trófico do tecido conjuntivo (centella asiática), além do ...

  1. clinico-pathologic characteristics and treatment outcomes in children ...

    African Journals Online (AJOL)

    2009-12-01

    Dec 1, 2009 ... R. Pamnani, MBBS, MD(Path), Lecturer, Haematology and Blood ... Only two patients (8.6%) had surgery as part of treatment ... patient was alive, (also free of disease), five years after diagnosis. ... there is neck involvement.

  2. A clinico-epidemiological study of rescuer burns.

    Science.gov (United States)

    Basra, Baljeet Kumar; Suri, Manav P; Patil, Nilesh; Atha, Ravish; Patel, Natvar; Sachde, Jayesh P; Shaikh, M F

    2014-08-01

    Rescuer burn is a relatively newer terminology introduced to define the burns sustained by a person attempting to rescue a primary burn victim. Few studies have been published thus far on this peculiar type of burns. Due to the general neglect of the rescuer burns victim and discontinuation of treatment in most cases, once the primary victim dies, the rescuer often ends up in badly infected wounds and has a delayed return to work. A prospective study was conducted at the B J Medical College and Civil Hospital, Ahmedabad from January 2009 to December 2012 on the rescuer burns patients treated in its burns and plastic surgery department. 3074 patients of burns received treatment during the period of study. Of these, 48 patients gave the history of sustaining burns while trying to rescue a burns victim. Male to female ratio of rescuers was approximately 7:1. It was significantly higher as compared to the ratio of 1:0.8 of females to male burn victims observed at our centre (p≤0.01). Average age of the rescuers was higher in males as compared to females but the difference was not significant (p≥0.05). Of the 45 cases of female primary burns victims, male rescuer was husband of the primary victim in 41/45 cases (91.1%), mother was rescuer in three cases (6.6% cases) and sister was rescuer in one case. Though multiple people came to rescue a burns victim, in all cases, it was seen that it was the first rescuer who sustained burns himself or herself. None of the rescuers had any knowledge of the techniques and precautions to be taken while performing a rescue operation irrespective of their education status, indirectly pointing to the lack of any teaching on burns rescue in the school education curriculum.

  3. EVALUACIÓN HIGIÉNICA DE UN CENTRO CLINICO

    OpenAIRE

    Pascual García – Núñez, Víctor

    2016-01-01

    La presente Tesis Fin de Master aborda la evaluación de riesgos higiénicos realizada en el Centro de Cirugía Majus S.A. perteneciente al Grupo Pica S.L. En esta evaluación higiénica se identifican y valoran los principales riesgos higiénicos (agentes físicos, químicos y biológicos) a los que pueden estar expuestos los trabajadores durante su jornada laboral y el riesgo que les supone, con el objeto de colaborar en el cumplimiento del artículo 16 de la Ley 31/1995, de Prevención de Riesgos Lab...

  4. Clinico-Epidemiological And Microbiological Evolution Of Pertussis

    Directory of Open Access Journals (Sweden)

    I. V. Babachenko

    2009-01-01

    Full Text Available The article deals with the data, which manifests the increasing part of vaccinated children and children older, then 7 years, among the hospital patients with whooping cough in Saint-Petersburg during 1990-2006 yy. The researchers have described the dynamics of dominating serotype changes among the hospital patients from 1.2.3. between 1990-2000 up to 1.0.3. between 2002-2006 and molecular-genetic characteristics of 13 strains of B. рertussis. Analysis of the clinical picture of the disease among 138 children, producing strains of B. рertussis of serotypes 1.2.3. and 1.2.0. (93 children or strains of B. рertussis of serotypes 1.0.3. (45 children showed that biological strains mutability of B. рertussis causes changes in severity and clinical course of рertussis infection, without effecting the clinical picture of the disease. Strains of B. рertussis of serotypes 1.0.3., IVb EFPP-group (during electrophoresis in pulsating gel, pertussis toxin A, pertactin 2 are associated with less severe illness forms (by 2,5 times, as well as specific complications (breath-holding and pertussis encephalopathy.

  5. [Clinico-morphological variants of gastric mucosa atrophic lesions].

    Science.gov (United States)

    Naumova, L A; Pal'tsev, A I; Beliaeva, Ia Iu

    2009-01-01

    To characterize clinicomorphological manifestations of atrophic process (AP) in gastric mucosa (GM) in chronic atrophic gastritis (CAG) associated and not associated with Helicobacter pylori infection. Clinicoendoscopic and pathomorphological (light microscopy of gastric biopsies, 6 point scale assessment of dysregeneratory alterations) investigations were made in 98 patients aged 16 to 68 years. H. pylori-negative CAG was diagnosed in 52 of them, H. pylori-positive one in 46 patients (groups 1 and 2, respectively). A comparative clinicomorphological analysis has identified 2 variants of AP morphogenesis in GM. Variant 1 is not associated with H. pylori but associated with a combined action of several endogenic risk factors of chronic gastritis or failure of regeneration, with diffuse or diffuse-focal changes with initial prevalence of dysregeneratory changes in a fundal stomach manifesting as a trend to atrophy of the glands. Clinically, this variant is characterized by longer disease, frequent systemic atrophic lesions of gastrointestinal mucosa, prevalent complaints of dyspeptic pain. Variant 2 is associated with a combined action of endo- and exogenic factors, H. pylori infection in particular, pathogenetic components of "chemical" gastritis (duodenogastric reflux, malnutrition), prevalence of dysregeneratory and sclerotic alterations in the antral stomach. GM atrophy is characterized by a significant frequency of concomitant endocrinopathies, undifferentiated connective tissue dysplasia, systemic lesions, structurally--by multidirectional disorders of proliferation and differentiation. First of all, it is the result of impaired regulation of regenerative processes. AP polyetiology and different morphogenetic variants in GM suggest necessity of both individual diagnostic algorithm and pathogenetically sound therapy in each individual case.

  6. [Primary empty sella. Clinico-radiologic considerations in 18 cases].

    Science.gov (United States)

    Pompili, A; Jachetti, M; Carapella, C M; Crecco, M; Gaudino, G; Isabella, F; Mastrostefano, R

    1985-01-28

    18 patients with "primary empty sella" were reviewed for this study. In 3 of them the sellar enlargement was discovered occasionally by performing skull radiographs for other reasons. The galattorrhea-dismenorrhea or amenorrhea syndrome and obesity were the most common clinical features. Endocrinological tests were normal in ten patients and abnormal in eight. Slight elevation of serum PRL was the most common record. 12 patients had enlarging of the sella turcica; in 4, only the floor was asymmetric and in 2 the sella was quite normal. In 5 patients C.T. without intra-thecal contrast was sufficient to discover the E.S. In 13 patients we performed C.T. cysternography by injecting in the lumbar subarachnoid space 8-10 ml of Iopamidolo 200. This is an excellent and safe technique to perform C.T. cysternography.

  7. Clinico-epidemiological characteristics of patients presenting with organophosphorus poisoning

    Directory of Open Access Journals (Sweden)

    Indranil Banerjee

    2012-01-01

    Full Text Available Background: Organophosphorus (OP poisoning is a major health problem all over the world, particularly in the developing countries. Aim: The present study aims to explore the clinical and epidemiological features found in patients presenting with OP poisoning. Materials and Methods: A 1-year cross-sectional study was conducted on patients presenting with clinical features of OP poisoning in a tertiary care medical college. Results: A total of 968 patients presented during the study period. Poisoning with suicidal intent (82.02% was more common than the accidental one (17.98%. Majority of the patients were housewives (42% followed by farmers, shopkeepers, laborers, students. Methyl parathion was the most common poison consumed by the patients (35.74% followed by diazinon, chlorpyriphos, dimicron. Nausea and vomiting (85.02% was the most common symptom while miosis was the most common sign observed in 91.94% patients. A total of 56 patients of OP poisoning died (5.78% with respiratory failure being the primary cause of death followed by CNS depression, cardiac arrest, and septicaemia. Conclusion: The present study showed that majority of the patients were of young age with females outnumbering males. Poisoning with suicidal intent was more common than accidental. Nausea and vomiting was the most common symptom reported by the patients while miosis was the most common sign observed by the treating physicians of the research team.

  8. [CLINICO-EXPERIMENTAL SUBSTANTIATION OF INTRAABDOMINAL PLASTY FOR UMBILICAL HERNIAS].

    Science.gov (United States)

    Joffe, O Yu; Shvets, I M; Tarasyuk, T V; Stetsenko, O P; Tsyura, Yu P

    2015-04-01

    The impact of various methods of plasty, using net implants, on results of umbilical hernias treatment was studied in experimental and clinical investigation. The umbilical hernias plasty was performed in accordance to the IPOM (intraperitoneal on lay mesh) method, application of which have permitted to reduce a hospital stay of the patients as well as their period of social rehabilitation, and to guarantee the best cosmetic effect in comparison with such while making umbilical hernias plasty in accordance to a sub lay method.

  9. Neonatal necrotizing entero-colitis: A clinico-surgical study

    Directory of Open Access Journals (Sweden)

    A.I. Eid*

    2013-12-01

    Conclusion: Early diagnosis and intensive medical and surgical treatment were mandatory to minimize both morbidity and mortality from NEC. Surgical management should be determined according to the special circumstances of each case. However, the optimum choice between peritoneal drainage and laparotomy remains controversial. Gestational age, birth weight, age at admission, and treatment modality are definite prognostic factors as regard morbidity and mortality of patients with NEC.

  10. Estudo genetico-clinico de glaucoma congenito primario

    OpenAIRE

    Andrea Trevas Maciel-Guerra

    1989-01-01

    Resumo: O Glaucoma Congênito Primário (GCP) é uma entidade genética heterogênea, geralmente considerada distinta da Megalocórnea e do glaucoma congênito de manifestação tardia ou juvenil. A fim de detectar indicações da heterogeneidade genética do GCP a nível clínico, foram examinados 67 portadores dessa anomalia, dos quais se obtiveram dados anamnésticos e de exame oftalmológico. Os resultados da análise se segregação, bem como a alta freqüência de consangüinidade observada nessa amostra ind...

  11. Ipertensione arteriosa, continuum cardiovascolare e ruolo clinico dei sartanii

    Directory of Open Access Journals (Sweden)

    Maurizio Destro

    2011-03-01

    Full Text Available The cardiovascular and cardiorenal continuum comprises the transition from cardiovascular risk factors to endothelial dysfunction and atherosclerosis, to chronic congestive heart failure, and-stage renal disease or premature death. RAAS (renin-angiotensin-aldosterone system is involved in all steps along this pathway. Data from clinical studies involving valsartan and other ARBs provide evidence of the reduction of risk of cardiovascular events, and end-organ damage in the heart, kidneys and brain. This paper summarizes the status on research of ARBs based on clinical trials and regulatory approval.

  12. Neurosyphilis: A Clinico- Radiological Study | Patel | African Journal ...

    African Journals Online (AJOL)

    Our series of patients were reviewed to describe the clinical and radiological findings. ... demographic, clinical, laboratory and radiological findings were extracted. Patients HIV status was also recorded. ... Thirty-nine of these had radiological data. ... has protean manifestations and can affect any central neurological system.

  13. Macrodystrophia lipomatosa: Review of clinico-radio-histopathological features

    Science.gov (United States)

    Majumdar, Banashree; Jain, Atul; Sen, Debashis; Bala, Sanchaita; Mishra, Pranshu; Sen, Sumit; Biswyas, Projna; Behra, Akhilesh

    2016-01-01

    We report clinical, radiological, and pathological features of three cases of macrodystrophia lipomatosa, which is characterized by progressive proliferation of all mesenchymal elements, with a disproportionate increase in fibroadipose tissue. The peculiarity in our report is the involvement of contralateral hand and feet in our 1st case in contrast to usual presentations of this rare condition, which is often unilateral. In our 2nd case, the lateral aspect of foot was involved as against the usual finding of involvement of medial aspect in lower limbs, also another surprising finding in this case is increase in the size of lesion after puberty. Coming to our 3rd case, enlargement of almost whole of an upper extremity with profound involvement of middle, ring and little finger along with total sparing of the thumb is in itself an extremely rare occurrence as in upper limb, mainly the lateral aspect of hand and related digits bear the burnt and more over involvement of whole limb is itself an unique phenomenon. PMID:27559507

  14. Macrodystrophia lipomatosa: Review of clinico-radio-histopathological features

    Directory of Open Access Journals (Sweden)

    Banashree Majumdar

    2016-01-01

    Full Text Available We report clinical, radiological, and pathological features of three cases of macrodystrophia lipomatosa, which is characterized by progressive proliferation of all mesenchymal elements, with a disproportionate increase in fibroadipose tissue. The peculiarity in our report is the involvement of contralateral hand and feet in our 1st case in contrast to usual presentations of this rare condition, which is often unilateral. In our 2nd case, the lateral aspect of foot was involved as against the usual finding of involvement of medial aspect in lower limbs, also another surprising finding in this case is increase in the size of lesion after puberty. Coming to our 3rd case, enlargement of almost whole of an upper extremity with profound involvement of middle, ring and little finger along with total sparing of the thumb is in itself an extremely rare occurrence as in upper limb, mainly the lateral aspect of hand and related digits bear the burnt and more over involvement of whole limb is itself an unique phenomenon.

  15. A Clinico - Aetiological Study Of Dermatoses In Paediatric Age Group

    Directory of Open Access Journals (Sweden)

    Ghosh Sadhan K

    1995-01-01

    Full Text Available Five hundred patients of the age group 0-12 years were studied for different types of dermatoses. Pyoderma (35.6%, scabies (22.4% and eczema (17.6% were the most common dermatological conditions, followed by molluscum contagiosum (4.6%, popular urticaria with insect bite (4%, vitiligo (3.4%, miliaria (2.8%, nevus (1.6%. Other dermatoses (8% were pityriasis rosea, wart, chicken pox, herpes zoster, acne vulgaris, leprosy, angular stomatitis, pruritus vulvae, psoriasis, candidiasis, condylomatalata, fixed drug relation, tinea capitis and corporis, phrynoderma, alopecia areata, phimosis, geographic tongue, trichotillomania, canitis, pediculosis, hypertrophic scar and pityriasis versicolor.

  16. [Acute appendicitis: clinico-diagnostic and therapeutic considerations].

    Science.gov (United States)

    Carditello, A; Bartolotta, M; Bonavita, G; Lentini, B; Sturniolo, G

    1985-04-01

    Since january 1970-december 1982, 58 patients underwent emergently appendectomy for acute appendicitis. 31 (53,4 percent) where males; the average age was 21 +/- 2,3 years (M +/- SEM). The duration of symptoms ranged from 1-6 hours (10,3 percent of cases) to over 48 hours, before the hospital admission (15,4 percent of cases). 27 patients (46,5 percent) had a clinical examination at home by a physician. 21 patients (36,4 percent) came to hospital emergency unit without previous physical examination; 10 (17,2 percent) were transferred from other departments. In 6,9 percent of cases was present a perforated appendicitis with peritonitis. During operation, in 50 percent of patients was performed a therapeutic peritoneal lavage. In 63,7 percent of cases multiple drains were placed in peritoneal cavity. In all patients was effected postoperative antibiotic profilaxis. The mortality rate was 3,4 percent. General complications were observed more in patients with perforated appendicitis. This review suggests the following remarcable data: morbidity of this disease is still high; the physical examination is more important than laboratory work (especially in the elderly patients, which are often immunodepressed and in children, with leucocitosis-lack at hospital admission); early surgery is the most important factor to the improvement of prognosis in these cases and the results of surgical treatment are improved by large vertical incisions, peritoneal lavage and application of multiple intracavitary drains.

  17. Cowden syndrome- Clinico-radiological illustration of a rare case

    Directory of Open Access Journals (Sweden)

    Prashant B Patil

    2013-01-01

    Full Text Available Cowden syndrome (CS or multiple hamartoma syndrome is an infrequent genodermatoses, which is inherited as an autosomal dominant trait resulting from the mutation in the Phosphatase and Tensin homolog gene on the arm 10q and is principally characterized by multiple hamartomas with an increased risk of development of malignancies. Facial and oral signs are remarkable in the form of multiple papules and trichilemmomas on the face. We report one such rare case of CS in a 19-year-old patient who was diagnosed on the basis of her oral mucosal lesions and was further investigated and diagnosed with other hamartomas. The present case report signifies the responsibility of the oral physician in the early diagnosis of this progressive pathological syndrome as it leaves its footmark in the oral cavity in the form of oral mucosal lesions.

  18. Estados pre-leucemicos na infancia : estudo clinico e hematologico

    OpenAIRE

    Luiz Fernando Lopes

    1994-01-01

    Resumo: Fizemos uma avaliação retrospectiva de 18 crianças com pré-leucemia entre 320 pacientes que foram encaminhados ao Departamento de Pediatria do Hospital A.C.Camargo - São Paulo - entre janeiro de 1984 a dezembro de 1991 com diagnóstico prévio de leucemia para ser confirmado ou afastado. Leucemia linfocítica aguda foi confirmada em 227 pacientes e leucemia não linfocítica aguda em 54. Entre os 18 pacientes que foram classificados com pré-leucemia 8 apresentavam síndrome mielodisplásica,...

  19. Adrenoleucodistrofia (leucodistrofia melanodermica: registro de um caso anatomo-clinico

    Directory of Open Access Journals (Sweden)

    Mario Wilson Iervolino Brotto

    1979-06-01

    Full Text Available É relatado o caso de um paciente de 14 anos, do sexo masculino, com esclerose cerebral difusa precedida em 7 anos de sinais de insuficiência do córtex supra-renal, com antecedentes familiares. Clinicamente a doença é caracterizada por deterioração mental, distúrbios da marcha e da visão, associados com insuficiência do córtex supra-renal. Confirmando os dados da literatura, em nosso caso o estudo anátomo-patológico revelou desmielinização e gliose difusa na substância branca cerebral, poupando as fibras subcorticais. Células inflamatórias são comuns e têm distribuição perivascular. Na zona fasciculada e reticular da supra-renal, células "balonadas" são evidentes, muitas delas apresentando citoplasma vacuolizado e com estriações. Inclusões lipídicas similares têm sido encontradas nas células de Schwann dos nervos periféricos e dos testículos. Os achados são comparados com vinte casos da literatura.

  20. Miopatia miotubular: estudo clinico, eletrofisiologico e histologico de um caso

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    José L. Alonso

    1981-12-01

    Full Text Available São apresentados os resultados dos exames clínicos, eletrofisiológicos e do estudo do ponto motor, da imunofluorescência, da histoquímica e da ultrami-croscopia da biópsia muscular de um caso de miopatia miotubular. São discutidos estes resultados em relação aos achados de 56 casos desta moléstia consignados na literatura até 1978, sendo dada enfase à etiopatogenia.

  1. Infestazione sottocutanea da Dirofilaria spp.: descrizione di un caso clinico

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    Ilaria Crespi

    2007-12-01

    Full Text Available Dirofilaria spp. causes a common zoonotic filarial infection found in dogs and humans in the tropical, subtropical and temperate areas. After biological development in the mosquito, dogs and humans may be infected with the infective larvae when the mosquito takes a blood meal. In humans, the worms do not reach maturity, and no microfilariae can be detected.A number of species, such as D. tenuis, D. repens, D. immitis have been identified as causative agents of subcutaneous or conjunctival nodules in humans. Diagnosis is made by identifying the worm in biopsies or extracting the worm from the lesion. Surgical removal of the worms is the only known treatment.

  2. Infezione da Bartonella henselae: caso clinico e supporto diagnostico

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    Salvatore Nisticò

    2006-03-01

    Full Text Available Cat scratch disease is due to a bacterial infection sustained by Bartonella strains, transmitted to the human through the bite, scratch or lick of cats.We report a case about a young man who showed up to the Pediatrics outpatient clinic after he noticed a growing mass in his left armpit, preceded by malaise, fatigue and mild fever. The detection of the scar as a consequence of a cat scratch suggested the Bartonella infection diagnosis. Thus the patient had a blood test, the erythrocyte sedimentation velocity and specific antibodies assay: the measurement of serum Bartonella specific antibodies yelded high levels of IgM and IgG which confirmed the diagnosis.The patient was treated with a course of oral antibiotic, specifically Claritromicin 250 mg tablets BID for two weeks.After 30 days the axillary nodal mass downsized.The serum immunoglobulin assay cut down the time required for the formulation of the causative diagnosis and allowed for a prompt and aimed antimicrobial therapy. Compared with the blood culture, the antibodies test screening is quicker and highly reliable.

  3. Viral Warts-A Clinico-Epidemiological Study

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    Laxmisha Chandrashekar

    2003-01-01

    Full Text Available Although clinical criteria, laboratory diagnosis and treatment are well established, scanty attention has been paid to prevalence and pattern of viral warts in India. HIV is widely prevalent and its influence on the number and morphology of viral warts has not yet been studied in our setup. Hence, this study was undertaken. One hindered and forty four cases of viral warts were studied between September 2000 and June 2002 at the department of Dermatology and STD, JIPMER, Pondicherry. These included 81childeren and 63 adults. In Children, viral warts were most commonly seen in the age group of 10to14 years (41.9%, whereas in adults, the most commonly seen in the age 14to20 years (46.03%. The average age at presentation was 11.5 years. The male to female ratio was 2.2 to 1 in children and 1.8 to 1 in adults. Family history of warts was observed in 27.7% of the cases. In children, multiple site involvement (62.9% was more common than single site involvement. The most commonly involved site was hand in children as also in adults. In adults, single site involvement (66.6%was more common than multiple site involvement. The most common type of wart seen in both children and adults was the common wart. Twenty percent of the cases showed koebnerization. Four cases were found to be seropositive for HIV infection, who were adult with genital warts, but florid manifestations were not seen.

  4. Estudio de Rodilla Flotante en pacientes del Hospital Clinico Viedma

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    Omar Marcelo Vargas Fuentes

    2011-06-01

    Full Text Available Se denomina “Rodilla Flotante” a la combinación de fractura de fémur y tibia ipsilaterales. La incidencia exacta se desconoce, pero tiene un abordaje terapéutico complejo, una alta tasa de complicaciones y una elevada mortalidad.El presente estudio busca determinar los aspectos relacionados con esta patología en nuestro medio y analizarlos de una manera integral, realizándose para esto un estudio descriptivo y longitudinal retrospectivo abarcando 18 meses (de julio 2008 a diciembre 2009 que incluye a 17 pacientes con diagnóstico de “Rodilla Flotante” ingresados en el Servicio de Ortopedia y Traumatología del Hospital Clínico Viedma. Los resultados mostraronque esta lesión equivale al 1,9 % de los casos atendidos por este servicio. Siendo el 82,35% hombres. La edad promedio fue de 34 años. El mecanismo de producción más frecuente: accidentes en motocicleta (41,2%, seguido de atropellados (29,4%. En cuanto a la clasificación la mayor parte fue tipo I de Fraser (68,8%. El tratamiento quirúrgico definitivo se aplicó entre el 5° y 14° día en el 73.3%, mayormente usando clavos centro medulares en fémur y tibia. Los resultados del tratamiento fueron: excelentes 40%, buenos 33.3%, regulares 20% y pobres en el 6,6% según la escala de Karlstrom y Olerud. Las lesiones asociadas: TEC (80%, fracturas de pelvis (60%, trauma abdominal cerrado (60% y trauma de tórax (33,3%. Dentro de las complicaciones, un paciente falleció por fallamultiorgánica, otro concluyó en amputación, y cinco presentaron infección.Por lo que se concluye que en general los aspectos relacionados con esta patología, su presentación y tratamiento en nuestro medio, son similares a los que se encuentran descritos en la literatura médica.

  5. The sugar absorption test : clinico-pathophysiological considerations

    NARCIS (Netherlands)

    Elburg, Roelof Matthijs van

    1995-01-01

    After studying intestinal permeability in immunologic disorders, we studied intestinal permeability in a nonimmunologic disorder, exocrine pancreatic insufficiency.(chapter 5) In childhood, exocrine pancreatic insufficiency occurs mainly in patients with cystic fibrosis. We measured intestinal perme

  6. Clinico-Pathological Correlations of the Most Common Neurodegenerative Dementias

    OpenAIRE

    Taipa, Ricardo; Pinho, João; Melo-Pires, Manuel

    2012-01-01

    Neurodegenerative dementias are a group of neurological disorders characterized by deterioration in several cognitive domains in which there is selective and progressive loss of specific populations of neurons. The precise neurobiological basis for the different neurodegenerative dementias remains unknown. It is expected that different pathologies reflect different mechanisms, at least early in the neurodegeneration process. The next decades promise treatments directed to causes and mechanism...

  7. Macrodystrophia lipomatosa: Review of clinico-radio-histopathological features.

    Science.gov (United States)

    Majumdar, Banashree; Jain, Atul; Sen, Debashis; Bala, Sanchaita; Mishra, Pranshu; Sen, Sumit; Biswyas, Projna; Behra, Akhilesh

    2016-01-01

    We report clinical, radiological, and pathological features of three cases of macrodystrophia lipomatosa, which is characterized by progressive proliferation of all mesenchymal elements, with a disproportionate increase in fibroadipose tissue. The peculiarity in our report is the involvement of contralateral hand and feet in our 1(st) case in contrast to usual presentations of this rare condition, which is often unilateral. In our 2(nd) case, the lateral aspect of foot was involved as against the usual finding of involvement of medial aspect in lower limbs, also another surprising finding in this case is increase in the size of lesion after puberty. Coming to our 3(rd) case, enlargement of almost whole of an upper extremity with profound involvement of middle, ring and little finger along with total sparing of the thumb is in itself an extremely rare occurrence as in upper limb, mainly the lateral aspect of hand and related digits bear the burnt and more over involvement of whole limb is itself an unique phenomenon.

  8. Retroperitoneal ancient schwannoma: Review of clinico-radiological features

    Energy Technology Data Exchange (ETDEWEB)

    Loke, T.K.L.; Lo, K.K.L.; Lo, J.; Chan, J.C.S. [United Christian Hospital, Kwun Tong, (Hong Kong). Department of Diagnostics Radiology; Yuen, N.W.F. [United Christian Hospital, Kwun Tong, (Hong Kong). Department of Histopathology

    1998-05-01

    A case is reported here of an ancient schwannoma in the retroperitoneum. The findings of abdominal ultrasound and CT in a patient with a retroperitoneal ancient schwannoma are presented, and the clinical and radiological features of this unusual tumour are reviewed. The presence of a large, well-delineated complex cystic mass in the deep soft tissues should raise the possibility of an ancient schwannoma. It is important to recognize these tumours as benign with excellent prognosis so as to avoid unnecessary radical surgery. Copyright (1998) Blackwell Science Pty Ltd 12 refs., 2 figs.

  9. Clinico-pathologic conference: case 4. Langerhans cell histiocytosis (LCH).

    Science.gov (United States)

    Muramatsu, Takashi; Hall, Gillian L; Hashimoto, Sadamitsu; Miyauchi, Jun; Shimono, Masaki

    2010-12-01

    A 13-month-old Japanese boy presented with painless swelling in a left mandible and cheek. Intraoral examination revealed swelling in the left mandible and hemorrhage of oral mucosa due to biting. CT images revealed a wide osteolytic lesion of the left mandible with floating teeth. Biopsy was carried out and histopathological diagnosis was discussed.

  10. Cleidocranial dysplasia: clinico-radiological illustration of a rare case.

    Science.gov (United States)

    Mohan, Ravi Prakash S; Suma, Gundareddy N; Vashishth, Shirin; Goel, Sumit

    2010-03-01

    Cleidocranial dysplasia is an autosomal dominant condition caused by mutation of RUNX2, characterized by generalized dysplasia of the bones and teeth. Affected individuals have short stature, atypical facial features, and skeletal anomalies affecting mainly the skull and clavicle. The dental manifestations are mainly delayed exfoliation of the primary teeth and delayed eruption of the permanent teeth, with multiple impacted supernumeraries, and absence of cellular cementum. The frequency of this disorder is 1 per million individuals. Here we report a rare case of CCD in a 9-year-old male patient having most of the characteristic features of this syndrome. Interestingly, disorganized dentinal tubules were found in the roots of an extracted deciduous first molar, which seems to be a unique feature not reported previously.

  11. Clinico-pathological aspects of colorectal serrated adenomas

    Institute of Scientific and Technical Information of China (English)

    Ashish Chandra; Adnan A Sheikh; Anton Cerar; Ian C Talbot

    2006-01-01

    AIM: To study the association of colorectal serrated adenomas (SAs) with invasive carcinoma, local recurrence, synchronicity and metachronicity of lesions.METHODS: A total of 4536 polyps from 1096patients over an eight-year period (1987-1995) were retrospectively examined. Adenomas showing at least 50% of serrated architecture were called SAs by three reviewing pathologists.RESULTS: Ninety-one (2%) of all polyps were called SAs, which were found in 46 patients. Invasive carcinomas were seen in 3 out of 46 (6.4%) patients, of whom one was a case of familial adenomatous polyposis (FAP). A male preponderance was noted and features of a mild degree of dysplasia were seen in majority (n=75,83%) of serrated adenomas. Follow-up ranged 1-12years with a mean time of 5.75 years. Recurrences of SAs were seen in 3 (6.4%) cases, synchronous SAs in 16 (34.8%) cases and metachronous SAs in 9 (19.6%)cases.CONCLUSION: Invasive carcinoma arising in serrated adenoma is rare, accounting for 2 (4.3%) cases studied in this series.

  12. A Clinico-Pathological Study of Cervical Lymph Nodes.

    Science.gov (United States)

    Batni, Gaurav; Gaur, Sushil; Sinha, O N; Agrawal, Siddhant Priya; Srivasatva, Abhinav

    2016-12-01

    Cervical lymphadenopathy is one of the commonest presenting complaint of patient in ENT OPD Fine Needle Aspiration Cytology (FNAC) is one of the most reliable, less expensive, and basic diagnostic procedure for the definitive and conclusive diagnosis for the immune system which reciprocates in the form of enlarged lymph nodes. A study was conducted in ENT Department of Santosh Medical College, Ghazibad from August 2015 to May 2016 on 64 patients with enlarged cervical lymph nodes. FNAC was done to make the diagnosis. Out of 64 patients (51.5 %) was reactive non-specific, 28 % tubercular, 3.1 % lymphoma and 17 % were malignant. FNAC is one of the most dependable diagnostic tools in case of cervical lymphadenopathy for early diagnosis and detection for the better management.

  13. Clinico-pathological feature of pilomyxoid astrocytomas: three case reports.

    Science.gov (United States)

    Nagaishi, Masaya; Yokoo, Hideaki; Hirato, Junko; Yoshimoto, Yuhei; Nakazato, Yoichi

    2011-04-01

    Pilomyxoid astrocytoma (PMA) is a newly identified variant of pilocytic astrocytoma (PA). We report three cases of PMA with comparison to seven cases of PA in terms of their clinicopathological features. The three cases occurred at the ages of 2, 36 and 6 years, and their tumors were located in the left basal ganglia, the pineal gland, and the cerebellum, respectively. They were diagnosed PMA by surgical specimens that showed a characteristic monomorphous architecture with an angiocentric growth pattern and myxoid background. One patient developed localized relapse at 6 months after the surgery, but the other patients remained alive without tumor progression more than 5 years after treatment. In analysis of the immunohistochemical association in PMA and PA, no specific staining was found to be useful for differential diagnosis of PMA from PA. The expression of biomarkers including O-6-methylguanine-DNA methyltransferase, p53, MIB-1, and EGF receptor neither distinguished PMA from PA nor correlated with outcome. But almost all PMA and PA that demonstrated prominent positivity for nestin showed a high MIB-1 labelling index (LI), and four of these five patients suffered a relapse in the early phase. These results suggest that immunohistochemical expression of nestin and MIB-1 LI may correlate with the aggressiveness of the tumor in PA and PMA.

  14. Cowden syndrome- Clinico-radiological illustration of a rare case.

    Science.gov (United States)

    Patil, Prashant B; Sreenivasan, V; Goel, Sumit; Nagaraju, K; Vashishth, Shirin; Gupta, Swati; Garg, Kanika

    2013-01-01

    Cowden syndrome (CS) or multiple hamartoma syndrome is an infrequent genodermatoses, which is inherited as an autosomal dominant trait resulting from the mutation in the Phosphatase and Tensin homolog gene on the arm 10q and is principally characterized by multiple hamartomas with an increased risk of development of malignancies. Facial and oral signs are remarkable in the form of multiple papules and trichilemmomas on the face. We report one such rare case of CS in a 19-year-old patient who was diagnosed on the basis of her oral mucosal lesions and was further investigated and diagnosed with other hamartomas. The present case report signifies the responsibility of the oral physician in the early diagnosis of this progressive pathological syndrome as it leaves its footmark in the oral cavity in the form of oral mucosal lesions.

  15. Crouzon syndrome: clinico-radiological illustration of a case.

    Science.gov (United States)

    Mohan, Raviprakash Sasankoti; Vemanna, Naveen Shanker; Verma, Sankalp; Agarwal, Neha

    2012-01-01

    Crouzon syndrome, also called craniofacial dysostosis, is an autosomal dominant disorder with complete penetrance and variable expressivity. Described by a French neurosurgeon in 1912, it is a rare genetic disorder characterized by premature closure of cranial sutures, midfacial hypoplasia, and orbital defects. Here, we report a case of this rare entity. The patient presented with brachycephaly, maxillary hypoplasia, exophthalmos, mandibular prognathism, along with dental and orbital abnormalities.

  16. Fibrolamellar carcinoma: an unusual clinico-radiological presentation

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Preeti; Dhar, Sunanda; Strickland, Nicola H. E-mail: n.lovatt@ic.ac.uk

    1999-11-01

    We report a case of fibrolamellar carcinoma presenting in a 26-year old female. The patient had gross ascites at presentation. Imaging studies (ultrasonography and computed tomography) strongly suggested extensive intraperitoneal drop metastases.

  17. CLINICO PATHOLOGICAL STUDY OF PATTERNS OF ANEMIA DURING PREGNANCY

    Directory of Open Access Journals (Sweden)

    Chamakuri

    2015-10-01

    Full Text Available INTRODUCTION: Anemia is defined as haemoglobin level in the blood below the lower extreme of the normal range for the age and sex of the individual. According to WHO, in developing countries the prevalence of anemia among pregnant women averages 60%, ranging between 35 to 100% among different regions of the world. A hemoglobin concentration below 11.0g/dl or packed cell volume (PCV of less than 33.0% is regarded as anemia during pregnancy by the WHO. It occurs in 40 - 80% of the pregnant women. Iron and folic acid defici encies, malaria, intestinal parasitic infections and hemoglobinopathies are the principal causes of anemia in pregnancy. Predisposing factors include young age, grand multiparity, low socioeconomic status, illiteracy, ignorance and short intervals of pregn ancy. AIM AND OBJECTIVES: 1. To study various patterns of anemia in pregnant women having haemoglobin level < 11 gm%. 2. To determine the most common pattern of anemia in pregnancy based on red cell morphology. MATERIALS AND METHODS: This study is a prospe ctive study over a period of one year from September 2014 to August 2015 in the department of pathology, Andhra medical college, Visakhapatnam . The study was conducted on 120 pregnant women whose haemoglobin level is < 11 gm/dl. All the haemotological parameters & peripheral blood smear stained by Leishman’s stain were evaluated. Complete clinical & obstetric history was recorded. Socioeconomic status was also noted. RESULTS: Out of 120 cases of anemia, we found 47 patie nts (39.1% having dimorphic anemia, 36(30% – microcytic hypochromic anemia, 23(19.1% - normocytic hypochromic anemia, 11(9.16% - sickle cell anemia and 1(0.83% case of pancytopenia. Maximum cases were seen in the age group of 21 - 30 years. 52 cases (43. 3% were primigravida and remaining 68 cases (56.6% were gravida two to four. 20 cases (16.6% were diagnosed in the first trimester, 38 cases (31.6% in the second trimester & 62 cases (51.6s% in the third trimester. CONCLUSION: In conclusion, the commo n morphological patterns of anemia in this study are dimorphic anemia and microcytic hypochromic anemia. More common in the multigravida & in the third trimester of pregnancy. After the 1 st trimester there is increased fetal demand & hemodilution effect an d thus anemia occurs commonly in this period. The risk factors for anemia in this study are low socioeconomic status, multiparity & H/O complications during previous pregnancy. The socioeconomic conditions must be improved, early detection & good antenatal care to be provided for the prevention of anemia in pregnancy

  18. Abdominal tuberculosis in Ahmadi, Kuwait: a clinico-pathological review.

    Science.gov (United States)

    Abdul-Ghaffar, N U; Ramadan, T T; Marafie, A A

    1998-07-01

    For studying abdominal tuberculosis (TB) in Ahmadi, files off all patients admitted to our hospital with abdominal TB over 15 years (1981-1996) were reviewed. Nineteen patients are reported here. Young adults were predominant in our study. The non-Arab Asians were the most frequently affected group in relation to their population in Ahmadi, and Kuwaitis were the least frequently affected group. Abdominal pain, sweating, anorexia and fever were the most frequent presenting symptoms. Ascites and intestinal obstruction were the most frequent clinical presentations. Two patients presented with acute appendicitis and one patient had tuberculous pancreatitis. Abdominal lymph nodes, peritoneum, ileum and and caecum were the most frequently affected abdominal structures. We found laparoscopy very helpful in diagnosis of abdominal TB and we recommend it as the diagnostic method of choice. All our patients responded well to antituberculous chemotherapy. It should be kept in mind that abdominal TB still affects the indigenous and expatriate population of Kuwait.

  19. clinico-histopathologic types of maxillofacial malignancies with ...

    African Journals Online (AJOL)

    2011-02-02

    Feb 2, 2011 ... Results: Of the 528 malignancies recorded over the ten-year period, 427 (80.9%) were ... slight female to male predilection of 1.3:1 (5,6). Bone sarcomas: Osteosarcoma is the most common ... Rhabdomyosarcoma (RMS): A tumour of skeletal muscle ... an average age of occurrence at 31.73 years±16.785.

  20. Oral submucous fibrosis: A clinico-histopathological study in Chennai

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    Kiran Kumar K

    2007-01-01

    Full Text Available Background: Oral submucous fibrosis (OSF is a precancerous condition associated with the use of areca nut in various forms. There are very few reports to correlate the clinical stage to histopathological grading in OSF. Materials and Methods: A hospital-based study was conducted on 75 OSF cases who visited our hospital in Chennai from 2000-2003. A detailed history of each patient was recorded along with a clinical examination. Biopsy was performed for histopathological correlation. Clinical stage of the disease in terms of the ability to open one′s mouth was correlated with histopathological grading. Results: The male to female ratio of OSF cases was 6:1. All forms of areca nut products were associated with OSF. Chewing of paanmasala was associated with early presentation of OSF as compared to chewing of the betel nut. Out of 57 cases, which were in clinical stage II, 91.2% had histological grading of I and II in equal proportions and 8.8% had histological grade III. Out of 13 cases that showed a clinical stage of III, 52% showed a histological grade of II, 40% grade III and 8% grade I. Conclusion: In the present study, there was no direct correlation between clinical stages and histopathological grading. The possibility of difference in the severity and extent of fibrosis in different regions of the oral mucosa and involved muscles were considered as contributory factors for this variation.

  1. Superficial dermatomycoses: a prospective clinico-mycological study

    Directory of Open Access Journals (Sweden)

    Surekha A

    2015-01-01

    Full Text Available Background: Dermatomycoses are more prevalent in India due to favourable climatic conditions, poverty, poor hygiene and overcrowding. Sparse published data are available regarding superficial dermatomycoses from India. Methods: In this prospective study, demographic characteristics, clinical spectrum and risk factors for the development were studied in 198 patients with superficial dermatomycoses. Results: Their mean age was 34.1 ± 15.3 years; there were 108 (54.5% males. Majority of the patients (50.5% belonged to upper-lower socio-economic status (Class IV as per modified Kuppuswamy’s classification. Most of the patients (69.7% had presented with dermatophytoses. Among superficial dermatomy-coses, tinea corporis was the most common (29.3% clinical type. Potassium hydroxide mount was positive in 77.7% and culture was positive in 30.8%. Trichophyton rubrum was the most common species isolated (64%. Multivariable analysis using logistic regression revealed older age (> 50 years to be an independent predictor for the development of tinea corporis (p<0.001. Conclusions: Our observations suggest that superficial dermatomycoses are an important cause of morbidity and should be carefully searched for especially in the elderly so that effective curative treatment can be instituted.

  2. Cefaleia em salvas: aspectos clinicos e terapeuticos em 26 casos

    Directory of Open Access Journals (Sweden)

    Wilson Luiz Sanvito

    1980-12-01

    Full Text Available Vinte e seis casos de cefaléia-em-salvas são estudados do ponto de vista clínico e terapêutico. Nos aspectos clínicos são ressaltados a dramaticidade deste tipo de cefaléia, o nítido predomínio no sexo masculino, a média de idade dos pacientes, a presença de manifestações associadas e os fatores desencadeantes das crises nos períodos suscetíveis. Do ponto de vista terapêutico três esquemas medicamentosos foram utilizados: maleato de metisergida, prednisona e associação de ambas as drogas. Em 88,3% dos casos um resultado significativo foi alcançado, traduzido por melhora ou abolição das crises.

  3. Hemangiomas cavernosos do cranio: aspectos clinicos, radiologicos e terapeuticos

    Directory of Open Access Journals (Sweden)

    D. Kirchhoff

    1977-12-01

    Full Text Available São discutidos os aspectos relativos ao diagnóstico e tratamento dos hemangiomas cavernosos do crânio. Os dados obtidos em 26 casos, são apresentados, sendo salientado que a localização dos hemangiomas foi maior na região frontal, sendo mais atingido o sexo masculino. Os outros aspectos são coincidentes com os demais autores. A problemática desses tumores, principalmente a sua demonstração radiológica e o seu tratamento, são ressaltados, chegando-se à conclusão final de que o melhor meio de demonstração radiológica é a punção para contrastação direta do tumor. O tratamento de escolha é o cirúrgico, sendo a extirpação em bloco preferida nos casos de comprometimento ósseo importante, sendo a intervenção direta com dissecção e excisão reservada para as localizações nos tecidos moles ou com mínima participação óssea.

  4. Nummular headache: Clinico-epidemiological features in South Indian population

    Science.gov (United States)

    Rammohan, K.; Mundayadan, Shyma M.; Mathew, Robert

    2016-01-01

    Context: Nummular headache (NH) is a primary disorder characterized by head pain exclusively felt in a small-rounded area typically 2–6 cm in diameter. Aims: The aim of this review is to study the clinical and epidemiological features of NH in a patient population of South India and to compare this with that of described in the international literature. Settings and Design: A prospective, observational study conducted in a tertiary care center. Materials and Methods: Patients attending the medicine and neurology outpatient departments of a tertiary referral hospital in South India diagnosed to have NH as per the International Classification of Headache Disorders 3 beta (2013) criteria were studied over 30 months. All of the patients had a normal neurological examination. Neuroimaging findings were normal, except in one patient. Results: A total of 19 females and 10 males were studied. The mean age of onset was 47.62 years (range 36–60). The duration of headache varied from a minimum of 3 months to a maximum of 5 years, with a mean of 24.17 months. The site of headache was predominantly in the parietal area 15 (51.72%), followed by the occipital area 7 (24.13%). The mean diameter of the affected area was 3.23 cm. The intensity of the headache proved to be mild to moderate with a mean visual analog scale score of 5.03. The quality of pain was mainly felt as burning dysesthesia 12 (41.38%). In the majority of patients, i.e. 21 (72.41%), pain was chronic and continuous. None of the patients had any significant trophic change even though paresthesias, dysesthesias, and allodynia were reported by a significant minority of patients, i.e. 9 (31.03%). Only one (3.45%) patient gave a history of head injury. Ten (34.48%) out of 29 patients had other types of concurrent headaches; the majority of which proved to be migrainous, i.e. 7 (24.14%), 2 patients (6.89%) with tension headache, and 1 patient (3.45%) with trigeminal neuralgia. Conclusion: Our study proves the existence of the newly described primary headache syndrome called NH in South Indian population. In comparing our results with the international literature, the number of similarities is much greater than the differences. The etiology of pain in our series appeared to be primarily peripheral with a role for central pain sensitization in some cases due to a variety of concurrent central causes of head pain. PMID:27695232

  5. [Clinico-diagnostic evaluation of acute delirious syndromes in schizophrenia].

    Science.gov (United States)

    Panteleeva, G P

    1989-01-01

    Psychopathologic and nosologic issues of acute paranoid and Kandinsky-Clerambault syndromes are discussed on the background of clinical studies of 225 schizophrenic patients with these syndromes being initial manifestations. The data on the syndromes typology, clinical value and prognosis of acute delirious disorders are presented. These are shown to be not confined to progredient schizophrenia, including its paranoid form. Rather, they can manifest a course of the disease unspecific for schizophrenia, the so-called schizophrenic reactions and phasic states thus reflecting the course of latent schizophrenia. A differentiated approach to clinical and psychopathological analysis of acute delirious syndromes in schizophrenia is essential for adequate choice of medicosocial measures and epidemiologic investigations.

  6. Clinico-radiological study of cyst of the jaw

    Energy Technology Data Exchange (ETDEWEB)

    Park, Tae Won [Department of Oral Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1983-11-15

    The author analyzed 243 cases clinically and radiographically which were diagnosed as odontogenic cyst in SNUH during 10 years (1974. 1-1983. 12). The obtained results were as follows: 1. This cyst occurred more frequently in male than in female and the incidence was the highest in the 3rd decade. 2. Maxilla was more frequently affected than mandible. 3. Most of the odontogenic cysts were unilocular type (236 cases, 97.1%), showing distinct border (242 cases, 99.6%) with smooth margin (222 cases, 91.7%). 4. The adjacent teeth showed root resorption in 57 cases (23.5%), and root divergence in 52 cases (21.4%) 5. The cyst in lower jaw caused the displacement of the mandibular canal wall in 30 cases (31.2%). 6. The cyst in upper jaw extended to the maxillary sinus in 61 cases (41.5%).

  7. Appropriatezza della profilassi antibiotica in chirurgia: un audit clinico

    Directory of Open Access Journals (Sweden)

    Donatella Bologni

    2012-11-01

    Full Text Available Background. La profilassi antibiotica è un intervento efficace per la prevenzione delle infezioni della ferita chirurgica. La scelta degli schemi e delle modalità di somministrazione della profilassi antibiotica deve tenere conto delle evidenze scientifiche disponibili, oggi sempre più spesso sintetizzate in linee guida (LG. Infatti, perché la profilassi sia realmente efficace, è necessario che venga effettuata sia scegliendo gli antibiotici più appropriati, sia rispettando i tempi e la durata di somministrazione. Obiettivi. Valutare l’appropriatezza della profilassi antibiotica secondo quanto raccomandato dalle LG, individuare possibili aree di miglioramento e implementare il cambiamento delle pratiche professionali. Metodi. Un gruppo multidisciplinare ha effettuato una validazione delle LG sull’antibioticoprofilassi perioperatoria nell’adulto, pubblicate nel 2008 dal Sistema Nazionale Linee Guida (SNLG. Quindi è stata effettuata una revisione delle cartelle cliniche relative agli interventi chirurgici programmati eseguiti nel mese di febbraio 2010, poi confrontate con un campione di cartelle del mese di febbraio 2011. Per ogni intervento è stata valutata l’appropriatezza della profilassi antibiotica secondo quanto raccomandato dalle LG. Risultati. Sono state analizzate 115 cartelle cliniche nella prima rilevazione (2010 e 111 nella seconda (2011. Complessivamente è stato rilevato un incremento dell’aderenza alle raccomandazioni delle LG dal 43% al 64% tra la prima e la seconda rilevazione. In particolare, si è ridotta sia la percentuale di casi in cui veniva utilizzato un antibiotico diverso rispetto a quello raccomandato dalla LG (34% vs 55%, sia la percentuale di casi in cui veniva prescritta una posologia differente (10% vs 18%. Inoltre si è rilevato un miglioramento del timing di somministrazione (19% vs 40%. Rimane molto elevata, addirittura superiore alla prima rilevazione, la percentuale di pazienti in cui l’antibiotico viene proseguito oltre le 24 ore (37% vs 29%. Limiti. La modesta numerosità del campione analizzato rappresenta un limite dello studio che non può essere considerato omnicomprensivo di tutti i comportamenti prescrittivi rispetto alla profilassi antibiotica. Conclusioni. La stesura delle LG , seguita da un processo di implementazione ed applicazione alla realtà locale, ha tenuto conto della realtà epidemiologica e delle scelte di politica antibiotica; la condivisione del protocollo di profilassi con i professionisti, l’attenzione ai problemi organizzativi, l’assegnazione di specifiche responsabilità sono risultati essere una carta vincente anche se per giungere a risultati ottimali saranno necessari interventi ripetuti e costanti nel tempo.

  8. Clinico- histopathological study of subacute cutaneous lupus erythematous

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    Mittal R

    2001-01-01

    Full Text Available Fourteen cases of sub acute cutaneous lupus erythematosus (SCLE were selected from Dermato- Venereology outpatients during the last 2½ years. Clinically all patients revealed photosensitivity and annular plaques either covered with peripheral collarette of scale or EM - like or DLE - like lesions. Systemic associations were arthralgia in 4, hypertension in I. rheumatoid arthritis in I and pulmonary tuberculosis in L Histopathologically epidermal atrophy, interface dermatitis, basal cell degeneration, colloid bodies and mononuclear infiltrate of dermis were salient features. Good response to 15 mg prednisolonc, medium potency topical steroids and sunscreens was seen in all cases.

  9. Distrofia muscular congênita estudo clinico de 17 pacientes

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    A. S. B. Oliveira

    1991-09-01

    Full Text Available Descrevemos 17 pacientes (12m, 5f com idades que variaram de 1 a 24 anos (mediana 6 anos com distrofia muscular congênita (DMC, que foram estudados do ponto de vista genético, clínico, laboratorial, eletrofisiológico e anátomo-patológico. A apresentação segundo a herança foi da forma esporádica (76,5% ou possivelmente autossômica recessiva (23,5%. A diminuição da movimentação fetal intra-uterina foi referida em 57% dos casos, hipotonia neonatal em 82% e retardo no desenvolvimento motor em 88,2%. Fraqueza muscular, diminuição dos reflexos profundos e contraturas articulares estavam presentes em todos os casos. A piora na função motora estava muito relacionada ao aumento ou aparecimento de novas retrações articulares. A CK nunca ultrapassou valores acima de 8 vezes o normal. O ENMG foi de padrão miopático em 73,3%, neuropático em 13,3% e normal em 13,3% dos casos. Aspectos tomográficos com hipodensidade da substância branca subcortical foram vistos em 8 casos. Ao tratamento impôs-se fisioterapia adequada e cirurgia corretiva das deformidades articulares. Novas contraturas desenvolveram-se mais tarde e estavam relacionadas freqüentemente a fisioterapia insuficiente.

  10. CLINICO PATHOLOGICAL STUDY OF CARCINOMA BREAST: A PROSPECTIVE STUDY

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    Madhu Shankar

    2015-12-01

    Full Text Available BACKGROUND Breast cancer is the most frequently diagnosed cancer in women and the second most cause of death in cancer. Over the past several decades there has been increase in incidence of the disease. Analysis of the incidence, clinical presentations, various risk factors, accuracy of FNAC and frozen section, incidence of various pathological types, stage at presentation and ER, PR, HER-2/neu status. METHODS In this prospective study, 51 consecutive patients who were diagnosed to have carcinoma breast admitted between April 2013 to April 2014 in the Department of Surgery, Rajarajeshwari Hospital, Bangalore, were included in the study. A detailed clinical history was elicited from all patients at the time of admission. All patients who had triple assessment evidence of malignancy were worked up for surgery with necessary investigations. Written consent was obtained from each patient for surgery. After data collection, it was checked, verified, edited manually for consistency to reduce error. Descriptive and graphical methods were used in analysing the data. The important variables were considered and analysed to fulfil the objective of the study. RESULTS In our study, the incidence of carcinoma breast is 5.6 per 1000, 32% of them were between 41-50 year age group, 63.3% had early menarche, 14.3% were nulliparous. Nearly 84.3% of them presented with lump of which 54% left sided involving upper outer quadrant 54.9%. Most cases belong to stage II and stage III at the time of presentation. FNAC was done in all cases with accuracy rate of 82.4%, followed by frozen section which showed about 71.4% of accuracy for those false negative cases. CONCLUSION Various risk factors in relation to breast carcinoma have been proved. As most of the cases presented late in our series because of lack of awareness, proper awareness and early screening by breast self-examination and mammogram should be emphasized. FNAC proved to be a simple and reliable procedure with good accuracy rate.

  11. Appropriatezza della profilassi antibiotica perioperatoria in pediatria: un audit clinico

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    Klaus Peter Biermann

    2012-08-01

    Full Text Available Background. La disponibilità di numerose evidenze scientifiche in tema di profilassi antibiotica perioperatoria, insieme alla necessità di uniformare la pratica clinica e verificare la trasferibilità delle raccomandazioni in ambito pediatrico, hanno motivato la decisione di pianificare un ciclo di audit presso l’Azienda Ospedaliero-Universitaria Meyer di Firenze. Obiettivi. Valutare l’appropriatezza dell’antibiotico profilassi secondo le raccomandazione formulate dalle più autorevoli linee guida; identificare gli ostacoli all’implementazione delle raccomandazioni e definire gli interventi finalizzati alla loro rimozione, inclusi l’aggiornamento e la diffusione del protocollo interno all’ospedale, redatto nel 2005. Metodi. Un campione di 115 interventi chirurgici è stato analizzato rispetto alla somministrazione della profilassi antibiotica in chirurgia pediatrica. La pratica prescrittiva è stata confrontata con quanto raccomandato dalle linee guida, verificando l’appropriatezza della somministrazione antibiotica, il timing, il dosaggio in rapporto al peso, il ricorso alla seconda dose in relazione alla durata dell’intervento e la scelta della molecola. Risultati. Il tasso di appropriatezza della profilassi antibiotica è del 87.8% (101/115, con un’appropriatezza d’uso (ricorso alla somministrazione, quando raccomandata dell’81.4% (35/43 e un’appropriatezza del non uso (non somministrazione, quando non raccomandata del 91.7% (66/72. Tra i 41 soggetti sottoposti a profilassi, 12 risultano in pre-trattamento e pertanto la scelta della molecola è condizionata dal trattamento in corso al momento dell’intervento. Dei rimanenti 29, il 75.9% sono sottoposti a profilassi con cefalosporine di III generazione, non raccomandate dalle linee guida. Limiti. Lo studio è stato condotto su un campione di 115 cartelle cliniche, pari a poco più del 3% dei dimessi nei primi sette mesi del 2011. La scelta dei criteri di appropriatezza, sebbene sostenuta da linee guida evidence-based, ha talvolta richiesto procedure di consenso non sempre unanimi. Conclusioni. Il ciclo di audit ha evidenziato la necessità di un aggiornamento del protocollo interno, poiché sono emerse nuove evidenze applicabili alla popolazione pediatrica. Inoltre, l’inappropriatezza delle molecole prescritte è un argomento che può beneficiare di interventi di monitoraggio intraospedaliero del consumo di farmaci. Il re-audit, previsto per la fine del 2012, permetterà di valutare l’efficacia di una serie di interventi per modificare la pratica clinica.

  12. A clinico-pathological study of 70 cases of pemphigus

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    Arya S

    1999-01-01

    Full Text Available A clinicopalhological study of 70 cases of pemphigus observed over a span of four and a half years from January 1992 to June 1996 at the Sir J.J. Group of Hospitals and Grant Medical College, Mumbai is reported. Pemphigus vulgaris constituted the single largest group of 43 cases, followed by pemphigus foliaceus (25 cases and pemphigus vegetans (2 cases. Majority of the cases were seen in the age group of 21-60 years, with a slight male predominance. The youngest patient was 14 years while the eldest was aged 75 years. Mucosal involvement was seen in 31 cases of pemphigus vulgaris, as opposed to only 5 cases of pemphigus foliaceus. Flaccid bullae were present in 100% cases. Pruritus was complained of in 14 cases, though it was more common in pemphigus vegetans and vulgaris. Salient histopathological features of pemphigus vulgaris observed were (I intraepidermal suprabasal blisters (35 cases, (2 presence of acantholytic cells (40 cases, (3 "Row of tombstone appearance" (I8 cases and (4 acantholysis involving follicular sheath (20 cases. Main histopathological features of pemphigus foliaceus were (1 subcorneal blister (15 case, (2 acantholysis (24 cases and (3 bulla cavity containing inflammatory infiltrate (12 cases. Both cases of pemphigus vegetans showed hyperkeratosis, papillomatosis and irregular acanthosis with intra-epidermal eosinophilic abscesses besides suprabasal lacunae.

  13. A CASE STUDY ON EPIDEMIOLOGY, CLINICO-PATHOLOGICAL, CLINICO-RADIOLOGICAL CORRELATION, MANAGEMENT AND FOLLOW UP OF CARCINOMA BREAST

    Directory of Open Access Journals (Sweden)

    Venkata Reddy

    2016-03-01

    Full Text Available BACKGROUND Breast carcinoma is the most common malignant tumour and the leading cause of death in women worldwide. It accounts for 15% of all cancer deaths in women. According to the World Health Organization (WHO, approximately 70% of breast cancers occur in women with none of the known risk factors. MATERIALS AND METHODS The study population comprised patients of carcinoma breast attending to surgical op and admitted in surgical units 1, 2, 3, 4, 5, 6 at Government General Hospital, Kakinada during November 2013 to November 2015. RESULTS Most common in females, breast lump is most common presentation, increased incidence in postmenopausal women, urban population has a higher incidence, upper outer quadrant is most commonly involved. CONCLUSION In our study, higher incidence is found in 5 th decade, mostly in postmenopausal women from urban areas, most commonly located in upper outer quadrant.

  14. Constitutional osteochondrodysplasias identifiable a birth. A short review on the state of the art in radiodiagnostic in the late 20. century; Le osteocondrodisplasie costituzionali riconoscibili alla nascita. Una breve rassegna sullo studio dell'arte radiodiagnostica sul finire del 20. secolo

    Energy Technology Data Exchange (ETDEWEB)

    Gugliantini, P.; Maragliano, G.; Piscione, M.; Licata, G. [Azienza Ospedaliera San Giovanni - Addolorata, Rome (Italy)

    1999-03-01

    The value of a systematic radiologic analysis in constitutional osteochondrodysplasias remains underestimated by both neonatologists and radiologists. The authors report the clinical experience of the Department of Neonatology and Neonatal Intensive Cure Unit of St. John Hospital in Rome with constitutional osteochondrodysplasias identifiable at birth. The authors justify the relatively high incidence of constitutional osteochondrodysplasias in this study (66% versus an average incidence of 0,076% reported in the world population) on the basis of: a) an increasing number of high-risk newborns in the intensive cure; b) an improvement in our clinical and radiologic diagnostic skill. They conclude that the state of the art of diagnostic of constitutional osteochondrodysplasiasin still based on the first plain X-ray examination performed at birth because of cardiorespiratory and/or abdominal diseases in the newborn. [Italian] L'importanza dell'analisi radiologica sistematica delle osteocondrodisplasie costituzionali e' tutt'ora sottostimata sia dai neonatologi che dai radiologi. Pertanto riferiamo l'esperianza clinico-radiologica di osteocondrodisplasie costituzionali identificabili alla nascita nel Dipartimento di Neonatologia e Terapia Intensiva Neonatale dell'Ospedale San Giovanni di Roma. L'articolo conclude giustificando la relativamente alta incidenza di ostecondrodisplasie costituzionali della casistica in esame (0,66% contro l'incidenza media dei 0,076% riferita alla popolazione mondiale) sulla base di: a) crescente numero di neonati con alto rischio ricoverati nella unita' di terapia intensiva; b) miglioramento delle capacita' diagnostiche, sia cliniche che radiologiche.

  15. Spondylotic myelopathy mimicking myelitis: diagnostic clues by magnetic resonance imaging.

    Science.gov (United States)

    Rua, Adriana; Blanco, Yolanda; Sepúlveda, María; Sola-Valls, Núria; Martínez-Hernández, Eugenia; Llufriu, Sara; Berenguer, Joan; Graus, Francesc; Saiz, Albert

    2015-12-01

    Introduccion. La mielopatia espondilotica es la causa mas frecuente de mielopatia no traumatica. Sus caracteristicas radiologicas en ocasiones son indistinguibles de las de una mielopatia inflamatoria, y pueden ocasionar retrasos diagnosticos o llevar a un diagnostico y tratamiento incorrectos. La descripcion reciente de un patron caracteristico de realce de gadolinio puede ayudar a diferenciar la mielopatia espondilotica de la causa inflamatoria. Casos clinicos. Caso 1: varon de 38 años que consulto por historia de dos años de evolucion de parestesias en las extremidades superiores, a las que se añadieron un año mas tarde calambres en las extremidades derechas y acorchamiento en los dermatomas C5 y C6 en relacion con los movimientos del cuello. Caso 2: varon de 44 años que consulto por historia de un año de evolucion de alteracion progresiva de la marcha con trastorno sensitivo en las manos y disfuncion vesical reciente. En ambos casos, la resonancia magnetica medular mostro en las secciones sagitales una hiperseñal cervical fusiforme en T2, asociada a una banda transversa de realce de gadolinio en forma de barra (pancakelike) justo por debajo de la zona de maxima estenosis, y un realce circunferencial o hemimedular en los cortes axiales. Conclusiones. Las caracteristicas radiologicas de la mielopatia espondilotica pueden parecerse a las de origen inflamatorio. El reconocimiento de un realce transverso en barra inmediatamente por debajo del lugar de maxima compresion como signo radiologico tipico de la mielopatia espondilotica es importante para reducir el riesgo de errores diagnosticos, y de utilidad para el manejo de estos pacientes.

  16. Association of CD44 Polymorphisms with Genetic Susceptibilities and Clinico-pathologic Characteristics in Breast Cancer%CD44基因多态性与乳腺癌遗传易感性及临床病理参数的关系

    Institute of Scientific and Technical Information of China (English)

    周鑫; 吴诚义

    2012-01-01

    Objective To explore the association of CD44 rs4756195 polymorphisms with genetic susceptibilities and clinico-pathologic characteristics to breast cancer of Han Nationality in Chongqing, China. Methods This case-control study included 170 patients with breast cancer and 178 healthy controls, single nucleotide polymorphisms (SNPs) of CD44 rs4756195 polymorphisms at intron 1 were genotyped by Sequenom Mass Array(R) iPLEX GOLD System. Data was analyzed via t test, Chi-square test and Logistic regression analysis. Results The frequencies of genotypes (AA, AG and GG) of CD44 rs4756195 showed a significant difference in the distribution of the genotypes between patients with breast cancer and healthy controls (χz =6. 272,P = 0. 043). The GG and AG genotype significantly increased the risk of breast cancer compared with AA genotype (OR —6. 035, 95%CI: 1.262-28. 856,P = 0. 024;OR = 5. 367,95%CI:1. 166-24. 709,P = 0. 031). The rate of axillary lymph nodes metastasis in patients with breast cancer who carried with GG genotype was higher than those carried with AG and GG genotype (62. 6% vs. 44. 7% , χ2 =4. 473 ,P = 0. 034). The positive rate of CD44 in patients with breast cancer who carried with AG and GG genotype was higher than those carried with GG genotype (68. 1 % vs. 45. 5% , χ2 = 6. 930,P = 0. 008). Conclusion CD44 rs4756195 polymorphisms are closely associated with the increased risk for breast cancer in Han Nationality; AG and GG genotype are susceptible genotype for breast cancer. CD44 rs4756195 polymorphisms are closely associated with the expression of CD44 and axillary lymph nodes metastasis, the patients with breast cancer who carried with GG genotype may have bad prognosis.%目的 探讨CD44基因rs4756195位点多态性与中国重庆地区汉族女性乳腺癌遗传易感性的关系.方法 采用病例对照研究,利用Sequenom MassArray(R) iPLEX GOLD系统检测170例乳腺癌患者和178例健康对照者CD44基因rs4756195位点单核苷酸多

  17. Aspectos virológicos e clínico-patológicos da infecção genital aguda e latente pelo herpesvírus bovino tipo 1.2 em bezerras infectadas experimentalmente Virological and clinico-pathological features of acute vulvovaginitis and latent infection by bovine herpesvirus 1.2 in heifers experimentally infected

    Directory of Open Access Journals (Sweden)

    Andréia Henzel

    2008-03-01

    and cows with bovine herpesvirus type 1.2 (BoHV-1.2 may result in vulvovaginitis and transient infertility. The acute infection is followed by the establishment of latent infection which can be periodically reactivated. We herein describe the virology and clinico-pathological aspects of acute and recrudescent vulvovaginitis in heifers inoculated with a Brazilian BoHV-1.2 isolate recovered from an outbreak of balanoposthitis. Genital inoculation of isolate SV-56/90 (10(8.1TCID50/animal in four eight-months-old heifers resulted in efficient virus replication in the genital mucosa and the development of moderate to severe vulvovaginitis. The inoculated heifers shed virus in genital secretions in titers up to 10(7.3TCID50/mL until day 10 pi and developed genital congestion, swelling, vesicles and pustules. The vesicles and pustules increased in size eventually coalesced and became covered with a yellowish exsudate. These signs appeared at day 2 pi, increased in severity up to days 5 - 8 pi and progressively subsided thereafter. Dexamethasone administration at day 55 pi resulted in virus shedding in vaginal secretions for up to 10 days. Virus reactivation in all animals was accompanied by clinical recrudescence of the disease, yet less severe than during acute infection. Examination of sacral ganglia and lymph nodes by PCR at day 36 post-reactivation revealed the presence of latent viral DNA in the pudendal (4/4, genito-femoral, sciatic and rectal caudal (3/4 and obturator nerve ganglia (1/4; in addition to several regional lymph nodes. These results demonstrate the virulence of isolate SV-56/90 for heifers and pave the way for its use in further pathogenesis studies and vaccine-challenge trials.

  18. Main radiation protection actions for medical personnel as primary responders front of an event with radiological dispersive device; Principais acoes de protecao radiologica para equipe medica como primeiros respondedores frente a um evento com dispositivo de dispersao radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Duque, Hildanielle Ramos

    2015-07-01

    After the terrorist attack in New York, USA, in 2001, there was a worldwide concern about possible attacks using radioactive material in conventional detonators, called as Radiological Dispersal Device (RDD) or 'dirty bomb'. Several studies have been and are being made to form a global knowledge about this type of event. As until now, fortunately, there has not been an event with RDD, the Goiania Radiological Accident in Brazil, 1987, is used as a reference for decision-making. Several teams with technical experts should act in an event with RDD, but the medical staffs who respond quickly to the event must be properly protected from the harmful effects of radiation. Based on the radiological protection experts performance during the Goiania accident and the knowledge from lessons learned of many radiological accidents worldwide, this work presents an adaptation of the radiation protection actions for an event with RDD that helps a medical team as primary responders. The following aspects are presented: the problem of radioactive contamination from the explosion of the device in underground environment, the actions of the first responders and evaluation of health radiation effects. This work was based on specialized articles and papers about radiological accidents and RDD; as well as personal communication and academic information of the Institute of Radiation Protection and Dosimetry. The radiation protection actions, adapted to a terrorist attack event with RDD, have as a scenario a subway station in the capital. The main results are: the use of the basic radiation protection principle of time because there is no condition to take care of a patient keeping distance or using a shielding; the use of full appropriate protection cloths for contaminating materials ensuring the physical safety of professionals, and the medical team monitoring at the end of a medical procedure, checking for surface contamination. The main conclusion is that all medical actions as primary responders must be followed up by radiation protection specialists. (author)

  19. Infratentorial angioleiomyoma: case report and review of the literature.

    Science.gov (United States)

    Delgado-Fernandez, Juan; Penanes, Juan R; Torres, Cristina V; Gordillo-Velez, Carlos H; Manzanares-Soler, Rafael; Sola, Rafael G

    2016-01-16

    Introduccion. Los angioleiomiomas intracraneales son lesiones muy poco frecuentes. Solo se han descrito 22 casos en la bibliografia hasta la actualidad, unicamente tres de ellos de localizacion infratentorial. Caso clinico. Varon de 43 años con un angioleiomioma infratentorial descubierto de forma incidental tras la realizacion de una tomografia computarizada por hipoacusia. La resonancia magnetica mostro una tumoracion de 1,4 cm, descrita inicialmente como un meningioma, con un realce progresivo tras la administracion de gadolinio, un aumento del coeficiente de difusion aparente y un descenso generalizado de metabolitos en la espectroscopia. La lesion se reseco quirurgicamente mediante un abordaje suboccipital con buena evolucion y sin complicaciones postoperatorias. En el estudio histologico, la lesion presentaba un abundante componente vascular, y en la tincion inmunohistoquimica era positiva para actina y caldesmona. Dos años despues de la cirugia, el paciente no presentaba recurrencia en la resonancia magnetica de control. Conclusion. El diagnostico de los angioleiomiomas puede ser complejo, pero algunas de sus caracteristicas radiologicas pueden facilitarlo. Los angioleiomiomas son tumores benignos asociados con un resultado funcional favorable tras su reseccion completa, que en nuestro caso no presento un alto riesgo de sangrado.

  20. [Posterior reversible encephalopathy: beyond the original description].

    Science.gov (United States)

    Avecillas-Chasín, Josué M; Matías-Guiu, Jordi A; Bautista-Balbás, Luis

    2015-07-16

    Introduccion. La encefalopatia posterior reversible (EPR) es una entidad clinicorradiologica caracterizada tipicamente por cuadros de cefalea, alteraciones visuales y crisis epilepticas, asociada a edema vasogeno corticosubcortical reversible en la neuroimagen. Objetivo. Presentar una revision de los aspectos fisiopatologicos de esta entidad y tambien de las asociaciones de la EPR descritas en la bibliografia. Desarrollo. Existe una serie de factores desencadenantes bien conocidos, como las crisis hipertensivas, la eclampsia o ciertos medicamentos. La descripcion de cada vez mas casos atipicos desde un punto de vista clinico y radiologico, asi como de posibles nuevos factores desencadenantes, obliga a una redefinicion de la entidad. Conclusiones. La EPR es un conjunto de manifestaciones clinicas y radiologicas que no se pueden enmarcar dentro la palabra 'sindrome'. Aunque la EPR se ha comunicado como irreversible en ciertos casos, el concepto de reversibilidad debe mantenerse en la definicion de esta entidad, ya que, en la mayor parte de los casos, el rapido control de la condicion desencadenante de la EPR permite la reversibilidad de las lesiones.

  1. An Assessment of the radiological vulnerability for Spanish soils; Estimacion de indices de vulnerabilidad radiologica para los suelos peninsulares espanoles

    Energy Technology Data Exchange (ETDEWEB)

    Trueba, C.; Millan, R.; Schimid, T.; Lago, C.; Gutierrez, J. [Ciemat. Madrid (Spain)

    2000-07-01

    A methodology is presented to assess the radiological vulnerability of soils, based exclusively on their pedagogical properties. The radiological vulnerability defined as the potential capacity of soils to fix or transfer deposited radiocaesium and radiostrontium to plants, is represented in terms of vulnerability indexes. Two pathways are considered, the external irradiation and their transfer through the food chain, where the top horizon and a critical depth of 60 cm is taken into account, respectively, Partial vulnerability indexes are considered for each pathway, which allows a qualitative prediction of the behaviour of the contaminants in soils Global indexes have been obtained as the sum of the partial indexes. The methodology has been applied and validated using a data base consisting of more than 2000 soil profiles selected from all over Spain. This included a pedagogical characterisation and normalisation of the different soil profiles. Results have been obtained for individual soil profiles and with the aid of a GIS, the distribution of the partial and global indexes have been presented for the most representative soil types. (Author)

  2. The recuperation of the irradiators, support of the radiation protection; La recuperacion de los irradiadores, soporte de la proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Rodriguez, Manuel; Tamayo, Jose Antonio; Gonzalez Rodriguez, Niurka; Villatoro, Mayra; Torres, Alberto; Turruela, Giovany; Gutierrez, Stefan; Vergara, Alex; Acosta, Andy Romero; Chacon, Jorge; Alonso, Gilberto; Ferrera, Eduardo Capote, E-mail: manolo@cphr.edu.cu, E-mail: jotag@cphr.edu.cu, E-mail: niurka@cphr.edu.cu, E-mail: jefelab@mem.gob.gt, E-mail: stefan@cphr.edu.cu, E-mail: alex@cphr.edu.cu, E-mail: andy@cphr.edu.cu, E-mail: jorgechacon@hotmail.com, E-mail: s, E-mail: gilberto@cphr.edu.cu, E-mail: capote@cphr.edu.cu [Centro de Proteccion e Higiene de las Radiaciones (CPHR), La Habana (Cuba). Servicios Electronicos

    2013-07-01

    Recovery of irradiators extend its life and avoid new spending on equipment purchases. Aged technique can still work effectively if it can do the maintenance, rather than a routine, a key priority. In this paper is presented the need of training of new specialists who join secondary laboratories, as well as other less new that did not have the opportunity of specialized training. Advanced knowledge are offered on: security measures to work with irradiators, hot spots that cause breaks in the control panel more frequently, as well as repair and maintenance are reported. It describes how to recover the solenoid with high quality assurance and minimal resources, change font, etc. All have empirical knowledge base.

  3. Radiological response of lanthanum guiding seeds in brachytherapy implants; Resposta radiologica de sementes guia de lantanio em implantes braquiterapicos

    Energy Technology Data Exchange (ETDEWEB)

    Silva, L.S.R.; Machado, E.D.P., E-mail: lais26@globo.com [Centro Federal de Educacao Tecnologica de Minas Gerais, Belo Horizonte, MG (Brazil). Departamento de Engenharia de Materiais; Campos, T.P.R. [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear; Roberto, W.S. [Centro Federal de Educacao Tecnologica de Minas Gerais, Belo Horizonte, MG (Brazil). Departamento de Fisica e Matematica

    2013-08-15

    Ceramic seeds with La-139 incorporated were synthesized to be used as radiological guides in brachytherapy implants. The synthesis was performed based on the sol-gel method. The seeds were subjected to characterization by Scanning Electron Microscopy, X-ray diffraction and Energy-Dispersive X-ray Spectroscopy. Furthermore, the contrast from a radiographic film was evaluated to lanthanum, samarium and holmium seeds. Radiological response on a phantom at different depths with lanthanum seeds and metal seeds was also investigated. Based on the values of contrast, the synthesized lanthanum seeds can be considered efficient as radiological guides when implanted together with pure Ho-165 and Sm-152 seeds. (author)

  4. The radiological protection in technical-professional level in Mexico; La proteccion radiologica a nivel profesional-tecnico en Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Vizuet Gonzalez, Jorge; Suarez, Gerardo [Instituto Nacional de Investigaciones Nucleares (ININ), Mexico (Mexico). Dept. de Proteccion Radiologica; Corona Montes de Oca, Julia [Centro de Bachillerato Tecnologico ' Justo Sierra' , San Mateo Atenco (Mexico)

    2005-07-01

    This work describes the work done in the implementation of an educational project which aims the formation of technical-professional in radiation protection (RP) with official recognition in Mexico. The constant growth of business activities related to the use of radioactive material in industry, medicine and research has required the development and implementation of standardization by the regulatory authorities of our country. However the advance with regards to training of specialized personnel is reduced in comparison to current needs. in our country there is no technical personnel with studies recognised by the regulatory body in this specialty (RP), however quality assurance programs currently require an educational training that will help to meet the standards in the various activities that develop in the use and handling of sources and ionizing radiation generating equipment, reason why it was developed and implemented this educational project. Additionally induce and promote the need for the peaceful use of nuclear energy and ionizing radiation, at the national level is one more reason to implement the programme at upper secondary level, with the purpose to have knowledge related to the topic. The technical course has a duration of six semesters (three years), and currently there are two generations of graduating. The plan of study consists of the required disciplines for upper secondary level more plus those corresponding to technological training in radiological protection.

  5. Ionizing radiation, nuclear energy and radiation protection for school; Radiacao ionizante, energia nuclear e protecao radiologica para a escola

    Energy Technology Data Exchange (ETDEWEB)

    Lucena, E.A.; Reis, R.G.; Pinho, A.S.; Alves, A.S.; Rio, M.A.P.; Reis, A.A., E-mail: arlene@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Silva, J.W.S. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Paula, G.A. de; Goncalves Junior, M.A. [Escola Sesc de Ensino Medio, Rio de Janeiro, RJ (Brazil)

    2017-04-01

    Since the discovery of X-rays in 1895, ionizing radiation has been applied in many sectors of society, such as medicine, industry, safety, construction, engineering and research. However, population is unaware of both the applications of ionizing radiation and their risks and benefits. It can be seen that most people associate the terms 'radiation' and 'nuclear energy' with the atomic bomb or cancer, most likely because of warlike applications and the stealthy way radioactivity had been treated in the past. Thus, it is necessary to clarify the population about the main aspects related to the applications, risks and associated benefits. These knowledge can be disseminated in schools. Brazilian legislation for basic education provides for topics such as nuclear energy and radioactivity to high school students. However, some factors hamper such an educational practice, namely, few hours of class, textbooks do not address the subject, previous concepts obtained in the media, difficulty in dealing with the subject in the classroom, phobia, etc. One solution would be the approximation between schools and institutions that employ technologies involving radioactivity, which would allow students to know the practices, associated radiological protection, as well as the risks and benefits to society. Currently, with the increasing application of ionizing radiation, especially in medicine, it is necessary to demystify the use of radioactivity. (author)

  6. Phyllodes tumor: clinical, radiological and pathological correlation in 50 cases; Tumor filodes: correlacion clinica, radiologica y anatomopatologica en 50 casos

    Energy Technology Data Exchange (ETDEWEB)

    Higueras, A.; Alvarez, M.; Jimenez, A.; Garcia Revillo, J.; Cano, A. [Hospital Universitario Reina Sofia. Cordoba (Spain)

    2000-07-01

    To review the radiological features of the phyllodes tumor, correlating them with the clinical presentation, histological type and response to treatment. Fifty phyllodes tumors in 29 patients aged 16 to 59 years (mean: 41 years) were analyzed retrospectively. The series included 12 cases of recurrence, 1 of bilateral tumor and 6 of multiple tumor. Forty-five lesions were studied by mammography and 36 by ultrasound. Clinically guided fine-needle aspiration cytology was performed in 8 cases. The pathological diagnosis was obtained by means of surgical biopsy in every case (31 benign and 19 malignant). Twenty-four patients underwent postoperative clinical and radiological follow-up for a mean period of 32 months. Mammography revealed the presence of a nodule or mass in 42 cases, asymmetrical density in two and a generalized increase in density in one: Multifocal lesions were detected in six cases. The size varied widely, with masses measuring >5 cm showing a greater probability of malignancy (p<0.01). Calcifications were observed in 13% of the cases. Ultrasound revealed the presence of heterogeneous, hypoechoic nodules, with cystic areas in five tumors, all of which were malignant (p<0.01). Local recurrence was detected in 31% of the cases and bone metastases in one. The phyllodes tumor is an uncommon fibroepithelial tumor that has a potential for recurrence and distant metastasis. Mammographic and ultrasound features are similar to those of the fibroadenoma, a lesion with which it is occasionally associated. Multiple lesions are not infrequent and it can present with calcifications. The presence of cystic areas and a tumor size of >5 cm are the only radiological findings that are statistically associated with malignancy. The recurrence rate is greater in malignant tumors than in benign lesions, especially in patients treated by tumor resection. (Author) 28 refs.

  7. Lung volume reduction surgery for emphysema: Radiologic findings; Valutazione radiologica nell`intervento di riduzione del volume polmonare per enfisema

    Energy Technology Data Exchange (ETDEWEB)

    Bonfioli, Claudio; Motta, Fabio; Bergonzi, Marco; Urani, Antonio; Montali, Giuseppe [Ospedale Generale `San Giuseppe`, Milan (Italy). Servizio di Radiologia; Varoli, Federico; Vergani, Contardo; Roviaro, Gian Carlo [Ospedale Generale `San Giuseppe`, Milan (Italy). Divisione di Chirurgia

    1997-04-01

    Aim of this work is to present and discuss the radiologic protocol they have developed for the preoperative assessment of patients with severe pulmonary emphysema candidate to lung volume reduction surgery (LVRS). The operation aims at improving respiratory mechanics and reducing small airway obstruction by removing variable amounts of emphysematous parenchyma. January to September, 1996, twelve patients were submitted to LVRS. Before surgery all patients were examined with standard chest radiographs during maximal inspiration and expiration, chest Computed Tomography (CT), High Resolution Computed Tomography (HRCT) and air trapping quantitation on HRCT scans. Diaphragm and chest wall excursions, patterns, site and distribution of emphysema, as well as heterogeneity were investigated, Air trapping was quantitate with a dedicated software. Post-operative studies were carried out 2 months later in 6 patients and included: maximal inspiratory and expiratory chest radiographs and air trapping assessment on 3 standardized HRCT scans. All parameters considered improved in every patient. Radiologic studies proved to be of crucial importance for patient selection and LVRS planning. The diagnostic protocol adopted in their Hospital appears a valuable tool for both pre- and post-operative assessment of the patients candidate to LVRS.

  8. Radiological protection procedures for industrial applications of computed radiography; Procedimentos de protecao radiologica em aplicacoes industriais da radiografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Aquino, Josilto Oliveira de

    2009-03-15

    Due to its very particular characteristics, industrial radiography is responsible for roughly half of the relevant accidents in nuclear industry, in developed as well as in developing countries, according to the International Atomic Energy Agency (IAEA). Thus, safety and radiological protection in industrial gamma radiography have been receiving especial treatment by regulatory authorities of most Member States. The main objective of the present work was to evaluate, from the radioprotection point of view, the main advantages of computed radiography (CR) for filmless industrial radiography. In order to accomplish this, both techniques, i.e. conventional and filmless computed radiography were evaluated and compared through practical studies. After the studies performed at the present work it was concluded that computed radiography significantly reduces the inherent doses, reflecting in smaller restricted areas and costs, with consequent improvement in radiological protection and safety. (author)

  9. Master Training in Radiological Protection Facilities Radioactive and Nuclear; Formacion de Master en Proteccion Radiologica en Instalaciones Radiactivas y Nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Verdu, G.; Mayo, P.; Campayo, J. M.

    2011-07-01

    The master includes general aspects of radiation protection in nuclear facilities. also an advanced module to acquire a high level training highlights as nuclear decommissioning, shielding calculation using advanced codes, particle accelerators, international law, etc.

  10. Safety requirements and radiological protection for ore installations; Requisitos de seguranca e protecao radiologica para instalacoes minero-industriais

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-06-15

    This norm establishes the safety and radiological protection requirements for mining installations which manipulates, process and storing ores, raw materials, steriles, slags and wastes containing radionuclides of the uranium and thorium natural series, simultaneously or separated, and which can cause undue exposures to the public and workers, at anytime of the functioning or pos operational stage. This norm applies to the mining installations activities, suspended or which have ceased their activities before the issue date of this norm, destined to the mining, physical, chemical and metallurgical processing, and the industrialization of raw materials and residues containing associated radionuclides from the natural series of uranium and thorium, including the stages of implantation, operation and decommissioning of the installation.

  11. The radiological protection in the practice of industrial X-rays; La proteccion radiologica en la practica de radiografia industrial

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez C, I.; Carrasco C, R., E-mail: ijcastro@cnsns.gob.m [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2010-09-15

    The kindness of this technique of non destructive assays is very appreciative when the protection standards and radiological protection are completed faithfully, this work show in a succinct way the development through the years where have improved the equipment s, the procedures, the training and the regulation. This development has allowed reduce the dose to the occupational exposed personnel, to the public, but mainly the accidents incidence with loss of fingers, hands, legs and worker lives, children and the people in general. (Author)

  12. The radiological protection of the environment: evolution and perspectives; La proteccion radiologica del medioambiente: evolucion y perspectivas

    Energy Technology Data Exchange (ETDEWEB)

    Real, A.; Robles, B.

    2013-09-01

    The radiation protection of the environment has led to growing interest in the last 25 years. Currently it is internationally accepted the need for a system which allows to explicitly demonstrate that the environment is adequately protected against the harmful effects of ionising radiation. to contribute to the development of this system, many international, European and national organizations have been actively working in the last decades. This paper describes how the radiological protection of the environment has evolved in the last decades, highlighting the knowledge acquired and the methodologies and tools developed, as well as the future perspectives in the field. (Author)

  13. Radiological protection of dental clinics: example of inspection methodology; Protecao radiologica em clinicas odontologicas: exemplo de metodologia de inspecao

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Jose Geraldo de [Coordenadoria de Vigilancia Sanitaria de Minas Gerais, Juiz de Fora, MG (Brazil)]. E-mail: jgdecastro@terra.com.br; Silva, Teogenes Augusto da [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Belo Horizonte, MG (Brazil)]. E-mail: teogenes.silva@cdtn.br

    2002-07-01

    The compliance with the radiation protection requirements was investigated at dental clinics with X-ray machines in Juiz de Fora, Minas Gerais State, Brazil. A questionnaire was elaborated based on national proposal from the regulatory body and applied only to dental clinics formally registered to the Regional Council. Data were obtained from the technical responsible staff, visual inspections on equipment and facilities. Results suggest that there is a gap between the staff perception and the reality as far as the compliance with the radiation protection requirements. As the application of a questionnaire is not enough to indicated the clinic radiological situation, an analysis methodology is proposed. (author)

  14. The radiological protection in the nuclear medicine practice; La proteccion radiologica en la practica de medicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Maldonado M, H., E-mail: hmaldonado@cnsns.gob.m [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2010-09-15

    The nuclear medicine practice dates of the 1950 years, in this work the achievements reached as regards radiological protection are shown, although even lack a lot to make, the doses for the occupationally exposed personnel have decreased with lapsing of the years, thanks to the perception of the nuclear physicians to improve the administration techniques of the radioactive material, the decrease of administered activity and the unit doses use among the most remarkable advances. The changes in the equipment s technology to quantify the activity to administer, detection systems and image formation have demanded the development of the new professionals of the nuclear medicine that allows give protection to the patient. This improvement needs to consolidate with the appropriate normative development, the involved personnel qualification and the methods and procedures actualization to improve the protection of the occupationally exposed personnel, the public, the environment and the patient. (Author)

  15. Radiological safety around a Linac of 18 MV; Seguridad radiologica alrededor de un LINAC de 18 MV

    Energy Technology Data Exchange (ETDEWEB)

    Ceron R, P.; Rivera M, T. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Calz. Legaria No. 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico); Paredes G, L. [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico); Azorin N, J. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, San Rafael Atlixco No. 186, Col. Vicentina, 09340 Mexico D. F. (Mexico); Sanchez, A. [IPN, Escuela Superior de Fisica y Matematicas, Av. IPN s/n, Edif. 9, Col. San Pedro Zacatenco, 07738 Mexico D. F. (Mexico); Vega C, H. R., E-mail: victceronr@hotmail.com [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 09868 Zacatecas (Mexico)

    2014-10-15

    There are now several neutron detection systems, such as proportional counters based on BF{sub 3}, He{sub 3} and Bonner sphere spectrometers. However, the cost and complexity of the implementation of such systems makes them inaccessible for dosimetry purposes in radiotherapy rooms (Rt) and other facilities with this type of radiation fields. For these reasons the use of a neutron detection system is proposed composed by a paraffin moderator media forming an array 4π (spheres) and several pairs of thermoluminescent dosimeters TLD 600/TLD 700 inside, in order to make useful measurements for radiation protection around high-energy lineal accelerators (Linacs). In the first part of this work the system response when irradiated with a source of Pu Be and their corresponding calibration factor is displayed. In the second part are presented the ambient dose equivalent (H(10)) due to neutrons at various points of a living of Rt with a Linac of 18 MV, which are in the order mSv/Gy by X-ray treatment. The measurements made are similar to those taken in the memories of the accelerator and in previous work for this type of facility. (Author)

  16. Project SIMORAC: a wireless system for radiation monitoring in emergencies; Proyecto SIMORAC: Un sistema inalambrico para monitorizacion radiologica en emergencias

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, D.; Serrano, J. L.; Cabrera, E.; Barbaran, J.; Llopis, L.; Diaz, M.

    2013-07-01

    The SIMORAC project includes a new system for Radiological monitoring using wireless sensor networks (RSIs), without infrastructure planning in emergency situations for a rapidly deployable by air or land, with the aim of providing a tool emergency teams capable of offering a real time x-ray map within the radius of action of an accident. Communication of quality at a great distance, resistance to weather, long autonomy and possibility of aerial deployment are some of the features of SIMORAC.

  17. Historic view of nuclear and radiological emergencies at Brazil; A saga das emergencias nucleares e radiologicas no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Azevedo, Eduardo M.; Estrada, Julio J.S.; Knoefel, Tom M.J. [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil); Recio, Joao C.A. [Comissao Nacional de Energia Nuclear (CNEN), Angra dos Reis, RJ (Brazil); Alves, Rex N. [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil)

    1999-11-01

    This paper presents, in a chronological way, the evolution of the Brazilian radiological and nuclear accident response system, emphasizing the National Commission on Nuclear Energy (CNEN) participation. From a single countermeasure procedure, known as scram adopted for the first research nuclear reactors built in the country, until the current plans to response the emergency situations the different phases are presented. Finally, the current programme is analyzed taking in consideration the organizations involved in this emergency planning. (author) 23 refs., 1 fig.; e-mail: eazevedo at ird.gov.br

  18. Report of radiological safety for a micro PET; Informe de seguridad radiologica para un microPET

    Energy Technology Data Exchange (ETDEWEB)

    Gallegos M, R.; Ruiz T, C. G.; Martinez D, A.; Rodriguez V, M., E-mail: romeo@fisica.unam.m [UNAM, Instituto de Fisica, Circuito de la Investigacion Cientifica, Ciudad Universitaria, 04510 Mexico D. F. (Mexico)

    2010-09-15

    Considering one of the guides emitted by the National Commission of Nuclear Security and Safeguards, was realized the report of radiological safety for a micro tomography by positrons emission that is part of Bimodal System of Images developed in their entirety for personnel of the Physics Institute of UNAM. With this system is sought to obtain tomography images of small animals using non destructive methods, such as computerized micro tomography and micro tomography by positrons emission. In this work each one of the report points is enumerated and only it is described, to big features on that consist, due to the great extension of each one of them. The report has two parts; the first is denominated -Of the installation and the Organization- and is given to know the interior and external characteristics of the installation, besides how and under which authority the activities will be executed inside the laboratory. The second part is called -of the Radiological Protection- and has for objective to describe the radiation sources that will be used, as well as the measures of radiological protection foreseen inside the laboratory. The most important part in the report consists on the description of the three radionuclides to use: {sup 18}F, {sup 11}C and {sup 13}N, as well as the methods for the shielding calculation and for the estimate of the dose equivalent during the normal operation of the equipment. These methods were applied three times, because the calculation was made for each radionuclide. The results of these calculations show that: 1) it not is necessary to have a structural shielding, due to the activity sources very reduced, and 2) the dose limit per year (according to the ICRP-60) it will not be surpassed neither in the case of the occupationally exposed personnel, neither on the public in general. (Author

  19. Technical support and preparations for the response to radiological emergencies; Soporte tecnico y preparativos para la respuesta a emergencias radiologicas

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas H, J.; Ramos V, E.O.; Fernandez G, I.M.; Capote F, E.; Zerquera J, T.; Garcia L, O.; Lopez B, G.; Molina P, D.; Lamdrid B, A.I.; Benitez N, J.C.; Salgado M, M. [CPHR, Calle 20 No. 4113, e/41 y 47 Playa, CP 11300, La Habana (Cuba); Lopez F, Y.; Jerez V, P. [CNSN, Calle 28 e/5ta y 7ta, Playa, La Habana (Cuba)]. e-mail: cardenas@cphr.edu.cu

    2006-07-01

    The work picks up the efforts directed to elevate the technical capacity of the answer in front of the radiological emergencies. Expressing them by means of the actions carried out as for teaching, research and development and intervention before accidental radiological events. The same one reflects the leading role of the participant institutions in those marks of the answer system to radiological emergencies that for its technical level it satisfies the national and international demands in the matter. In execution of the mentioned goals research projects guided to endow to the national system of methodologies and procedures for the administration of radiological emergencies have been executed that favor the improvement of its technical and organizational capacities. As well as the postulates of the National Plan of Measures for Case of Catastrophes in the corresponding to radiological accidents. (Author)

  20. Radiological security of portable equipment used in the industry; Seguridad radiologica de equipos portatiles utilizados en la industria

    Energy Technology Data Exchange (ETDEWEB)

    Cateriano, M.A. [Autoridad Regulatoria Nuclear, Av. Del Libertdor 8250, (C1429BNP), Ciudad Autonoma de Buenos Aires (Argentina)]. e-mail: mcateria@sede.arn.gov.ar

    2006-07-01

    The industrial meters with encapsulated sources are used intensely in the present time due to the economic benefits that generate. Their use in all the one world has been reflected in an improvement of the quality of the analyzed product and of one optimization of the production process, allowing to carry out these measurements and controls without interrupting the process and in non destructive form generating an energy saving in turn and of materials. Although these industrial meters are intrinsically safe for design in the portable meters their safety also is strongly governed in the strict pursuit of procedures and in the adequate personnel's training that operate these equipment. In the Argentine Republic in 2005 the Nuclear Regulatory Authority (RNA) had registered a quantity of 160 portable equipment. In the period 1995-2003, 2 incidents took place with these equipment one of them used to measure soils humidity of Troxler trademark containing a source of Am-241(Be) of 370 MBq and the remaining one also of Troxler trademark used to measure density and humidity of soils containing 2 sources of Cs-137 of 296 MBq and Am-241(Be) of 1.48 GBq respectively. The incidents were developed without relevant radiological implications had taken place. In this work those mentioned incidents are analyzed in order to determining the causes that originated the same ones, for this way to be able to elaborate recommendations with the purpose of to correct errors and to diminish the recurrence probability improving the safety in the use of these equipment. From the analyses of these incidents result that should put on more emphasis in the personnel training and the invigoration of the safety culture in the use of the industrial meters. Also a present panorama of the inventory of equipment, sources and users that possess these portable meters in the Argentine Republic is also presented. (Author)

  1. Use of social networks to improve radiation protection; Uso de las redes sociales para mejorar la proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Medina Gironzini, E.

    2013-07-01

    The development of information and communication technologies has improved relations between the specialists in radiation protection worldwide. Takes advantage of these media to exchange experiences on issues of common interest and technical concerns are resolved in very short times. (Author)

  2. Training activities in radiation protection and nuclear technology CIEMAT; Acciones formativas en proteccion radiologica y tecnologia nuclear de CIEMAT

    Energy Technology Data Exchange (ETDEWEB)

    Falcon Cabrera, S.; Fernandez Sanchez, J.; Marco Arboli, M.

    2013-07-01

    This work presents the different training activities that are being developed annually according to the demand detected in society, in business or in the national and international organizations involved, as well as the various forms of provision of these services by CIEMAT. (Author)

  3. Principles to establish a culture of the radiological protection; Principios para establecer una cultura de la proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Tovar M, V. M., E-mail: victor.tovar@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2013-10-15

    The term of Culture of the Radiological Protection means the way in which the radiological protection is founded, regulated, managed, preserved and perceived in the job places, with the use of the ionizing radiations, in the industry, in medicine and in any daily activity that reflects the activities, beliefs, perceptions, goals and values that all the involved parts concern in relation to the radiological protection. The principles to establish a culture of the radiological protection that should be established by the professionals of the radiological protection, following the recommendations of the International Radiological Protection Association (IRPA) are presented. (author)

  4. Current evaluation of the information about Radiological Protection in Internet; Evaluacion actual de la informacion sobre proteccion radiologica en Internet

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz-Cruces, R.; Marco, M.; Villanueva, I.

    2003-07-01

    To analyze the current situation about the pedagogic information on radiological protection training which could be found in Internet. More than 756 web-pages have been visited in Internet about Radiological Protection in the nuclear and medical fields, providing information mainly focusing on information to the members of the public. In this search were used internet Searching Appliance (as Copernicus, Google and Scirus), using key words related with this subject (as Radiological Protection and Health Safety), getting the internet address of organizations, societies and investigation groups. Only a low percentage (less than 5 per cent) of these addresses content information on Radiological Protection for the members of the public, including information about the regulator Organizations, and which are the objectives for protection of the members of the public against ionization radiation (from the point of view of the use of the ionization radiation in the medical and nuclear field). This work attempts to propose the use of internet as a tool for informing the members of the public in matter of radiological protection, as first link in the chain of the training and education. (Author)

  5. Radiological quality in drinking water from Granada city; Calidad radiologica del agua potable de la ciudad de Granada

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Penalver, J. J.; Gonzalez Gomez, C.; Ferro Garcia, M. A.; Prados Joya, G.

    2007-07-01

    The purpose of this study is to present data on gross alpha and beta activities in the drinking water from Granada city, during six years, 2000 to 2005. The samples were measured using a gas-flow proportional counter Bert hold LB 770-2/5. The results show that the gross alpha and gross beta cavity is lower than the maximum contaminant level based on the World Health Organisation, who which indicates 0.1 Bq.1-1 and 1.0 Bq.l''-1 as maximum contaminant level of gross alpha and gross beta radioactivity in potable water, respectively. Concentration ranging from 4.1.10''-3 to 3.9.10''2 Bq.l''-1 and from 4.9.10''-3 to 5.6.10''-2 Bq.l''-1 were observed from the gross alpha and beta activities, respectively. An average annual effective dose equivalent of 2.909 {mu}Sv-yr''-1 was obtained together with a range of 0.186 to 0.326 {mu}Sv.mo''-1. (Author) 10 refs.

  6. Digital processing methodology applied to exploring of radiological images; Metodologia de processamento digital aplicada a exploracao de imagens radiologicas

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Cristiane de Queiroz

    2004-07-01

    In this work, digital image processing is applied as a automatic computational method, aimed for exploring of radiological images. It was developed an automatic routine, from the segmentation and post-processing techniques to the radiology images acquired from an arrangement, consisting of a X-ray tube, target and filter of molybdenum, of 0.4 mm and 0.03 mm, respectively, and CCD detector. The efficiency of the methodology developed is showed in this work, through a case study, where internal injuries in mangoes are automatically detected and monitored. This methodology is a possible tool to be introduced in the post-harvest process in packing houses. A dichotomic test was applied to evaluate a efficiency of the method. The results show a success of 87.7% to correct diagnosis and 12.3% to failures to correct diagnosis with a sensibility of 93% and specificity of 80%. (author)

  7. Protective equipment of radiological protection and the worker wear; Equipamento de protecao radiologica e o desgaste do trabalhador

    Energy Technology Data Exchange (ETDEWEB)

    Cassia, Flor Rita de; Huhn, Andrea, E-mail: flor@ifsc.edu.br [Instituto Federal de Educacao, Ciencia e Tecnologia de Santa Catarina (IFSC), Florianopolis, SC (Brazil); Lima, Gelbcke Francine, E-mail: fgelbcke@ccs.ufsc.br [Universidade Federal de Santa Catarina (PEN/UFSC), Florianopolis, SC (Brazil). Programa de Pos-Graduacao em Enfermagem

    2013-11-01

    This qualitative research with workers of seven hemodynamic service of Santa Catarina, Brazil aimed to analyze the use of radiological protection equipment (RPE), as well as wear to the health of workers who use these causes. The study was conducted between March 2010 and November 2010, totaling approximately 30 hours of observations. Results showed resistance to the use of RPE and also showed wear to workers' health, mainly due to the weight and discomfort they cause, as may weigh 7-9 pounds, depending on the model used. Evidenced also the absence of workers due herniated disc, back pain, and other musculo skeletal problems. These complaints, in addition to being related to the use of these protective gear also related with the time that workers remain standing for long periods on certain procedures, such as angioplasty. Given these results, the research recommended the use of these devices with materials, that are already being produced, making lighter aprons, thus avoiding fatigue and back pain and also provide greater comfort by reducing workers' resistance to its use and its adverse consequences.

  8. Radiation protection in occupational exposure to microwave electrotherapy units; Proteccion radiologica en exposicion ocupacional a microondas en unidades de electroterapia

    Energy Technology Data Exchange (ETDEWEB)

    Guardia, V.; Ferrer, S.; Alonso, O.; Almonacid, M.

    2012-07-01

    During the last years, electromagnetic emitters are more and more commonly used for therapeutic treatments in electrotherapy centers. This extended use has caused worries workers, who believe that microwave radiation radiation might have effects similar to those induced by radioactivity, even if the only effects recognised by international regulatory bodies concerning microwave exposure of humans are those of thermal origin. The present study aims to answer the existing concerns about electromagnetic exposure in electrotherapy facilities. After monitoring environmental values in an electrotherapy facility, we conclude that actions must be undertaken in order to reduce the exposure levels, as proposed by the current European guidelines, which should become legally binding for all EU state members within the current year. With the purpose of reducing potential risks of occupational overexposure, we are developing innovative fabrics for microwave shielding. These new materials are able to attenuate 85% of the microwave radiation. As these are light materials, they can be used in all kind of facilities, as wall covers, movable screens or even as personal protection, like lab clothes or gloves. (Author) 6 refs.

  9. IMRT and radiation protection in the prostate cancer therapy; IMRT e a protecao radiologica no tratamento do cancer de prostata

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Helena C.; Silva, Andre R.M.; Oliveira, Claudia F.M., E-mail: andrerichard88@bol.com.br [Instituto Federal de Educacao, Ciencia e Tecnologia de Pernambuco (IFPE), Recife, PE (Brazil)

    2015-07-01

    This study aims to specify the technological advances that IMRT presents relative to other traditional radiotherapy, particularly to conformal radiotherapy three dimensional (3D-TCR) and benefits compared to the side effects caused by from treatment of radiotherapy.

  10. Information systems in radiation protection: the INIS database; Sistemas de informacion en proteccion radiologica: la base de datos INIS

    Energy Technology Data Exchange (ETDEWEB)

    Alberdi Larranaga, I.; Marco Arboli, M.

    2011-07-01

    INIS provides a comprehensive service references on literature information on radiation protection (RP), nuclear science and technology, medicine, etc.., Processing most of the world's scientific and technical literature in the area to meet the information needs international community in the areas of interest of the IAEA and the activities related to peaceful use of nuclear science and technology.

  11. Practising of radiological emergency caused by a terrorist attack; Ejercicio de emergencia radiologica ocasionada por un atentado terrorista

    Energy Technology Data Exchange (ETDEWEB)

    Racana, R.; Terrado, C. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250, Buenos Aires (Argentina)]. e-mail: rrcana@sede.ar.gov.ar

    2006-07-01

    After the events of September 11, 2001 terrorist working has become an important factor in the forecasts to adopt in the face of the possibility of confronting different radiological emergencies. The not wanted events of exposure to ionizing radiations can take place by flaws of systems or accidents, or also by criminal voluntary actions. These malevolent actions can include attacks or sabotages in nuclear plants, detonation of manufactured nuclear devices or acquired under ground, robbery of radioactive sources to manufacture the calls dirty bombs or to cause damage, panic or threats. In the scenarios in that the radiological emergency is voluntarily provoked the moment and place of the attack are chosen by the aggressors, therefore the ionizing radiations will be in not prepared atmospheres neither equipped to the effect. This increases the confusion, the panic and the damage not only caused by the radiation effects but also by the uncertainty and consequent reactions. To diminish the effects of this type of threats it is necessary to make forecasts and to train the personnel that it can be direct or indirectly involved. During 2005, an exercise in which it was outlined the robbery by part of a group command of a source of Co 60 of 5000 Ci that it was transported to make a decanting in a medical center of The Pampa county, Argentina. It was about a cabinet exercise, planned and executed jointly among the Nuclear Regulatory Authority and the Secretary of Interior Safety, in which participated the professionals of the nuclear area that by law are the responsible ones of coordinating the actions in the event of an emergency of this type, and the safety forces that depend of the Secretary of Interior Safety, Federal and Provincial Policemen, Naval Prefecture and National Gendarmerie. The exercise last one day during which 9 main situations were approached that were unchained after having produced the attack and initial robbery. For each situation it was checked the developed actions by each participant according to the role, those that finally were compared with the outlined solutions by the direction of the exercise. The exercise left important teachings, mainly: necessary coordination among the specialists team of the nuclear emergencies area and the members of the safety forces: information to toast to the diffusion media. Basic preparation in aspects related with ionizing radiations and protection with which should count the members of the safety forces. The necessity to make practices and combined exercises in frequent form. (Author)

  12. Training in fundamentals of radiological coverage in Laguna Verde NPP; Entrenamiento de fundamentos de coberturas radiologicas en la CLV

    Energy Technology Data Exchange (ETDEWEB)

    Lara H, M. A., E-mail: marcolarah@gmail.com [Comision Federal de Electricidad, Central Nucleoelectrica Laguna Verde, Carretera Cardel-Nautla Km. 42.5, Alto Lucero, Veracruz (Mexico)

    2014-10-15

    In 2010, the Institute of Nuclear Power Operations (INPO) celebrates the Knowledge Transfer and Retention Workshop, an event where nuclear regulators and operators presented the strategies that various NPP to worldwide were implemented to mitigate the consequences of this generational change and take advantage of it, the trend in the presented works was the same: the generational change occurs in a faster way that the transfer of knowledge, the future was already here and many NPP had not been adequately prepared to train its nuclear technicians and engineers in the tasks demanded by the industry of them, so in addition to preparing these workers to forced marches was necessary to establish strategies to retain at more experienced staff in the industry. The Laguna Verde NPP has not been exempt to this process; the preparation of personnel squares to replace those that reaching retirement age in the Comision Federal de Electricidad (CFE) has become extensive in the last five years, sometimes leading to have personnel covering functions without an alternate to the next lower position, the cause? Not enough staff. In the specific case of radiation protection (Rp) the time required for obtaining the status of Rp technician according to the ANSI/ANS 3.1 standard is 2 years, one of the tasks that most occupies part of these two years is training in radiological coverage, this training requires a mix of knowledge and experience, recently one of the concepts used for training in Rp is the evaluation and management of the radiological risk, topic that is considered in this technical work. (Author)

  13. Radiation nursery and occupational exposure: state-of-art; Enfermagem radiologica e os riscos ocupacionais: estado da arte

    Energy Technology Data Exchange (ETDEWEB)

    Melo, J.A.C.; Huhn, A.; Viana, E.; Rosa, G., E-mail: julianac@ifsc.edu.br [Instituto Federal de Educaco, Ciencia e Tecnologia de Santa Catarina (IFSC), Florianopolis (Brazil); Luz, K.R. [Universidade Federal de Santa Catarina (UFSC), Florianopolis (Brazil); Derech, R. [Prefeitura Municipal de Florianopolis, SC (Brazil)

    2015-07-01

    Documentary research with the aim to reflect on the state of the art in radiological nursing, on the nursing work and occupational hazards they are exposed, from articles produced in Brazil. The survey was conducted in the BVS, the study consisted of seven articles published from 2002 to 2012. Regarding the main variables studied in the articles, issues emerged related to working conditions and biosafety, performance of nurses, legislation, continuing education and difficulties and needs of nursing staff . It was noticed that is recent the interest in the field, but the work of nurses in radiological technologies must be grounded in current scientific knowledge and with proper technique, to the achievement of the desired clinical outcome and to promote their safety, the team and also the patient. (author)

  14. Risks estimation and radiological protection in radiodiagnostic. La estimacion de riesgos y la proteccion radiologica en el radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Calzado, A.; Chevalier, M.; Delgado, V.; Gonzalez, L.; Guibelalde, E.; Moran, P.; Vano, E.

    1993-01-01

    Actions of the Medical Physics Group from the Complutense University Medicine School in research projects related to radiation protection in the field of radiodiagnostics are described in this work, and some results presented. (Author) 23 refs.

  15. Radiologically detectable musculoskeletal involvement in systemic lupus erythematosus; Afectacion musculoesquelitca con expresion radiologica en el lupus eritematoso sistemico

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, M. M.; Manjon, P.; Diaz de Bustamante, T.; Galindo, M.; Buj, M. J.; Cabezudo, J. [Hospital Doce de Octubre de Madrid (Spain)

    2000-07-01

    We show a wide spectrum of musculoskeletal involvement in systemic lupus erythematosus (SLE) that can be detected by radiological examination. We determined the indications of different imaging techniques in the diagnosis and follow-up of this disease. We reviewed the clinical and radiological histories of 37 patients diagnosed as having SLE on the basis of serological and musculoskeletal criteria. We assessed the personal data of each patient, the association of the disease with autoimmune processes, serology, treatment and radiological findings using plain X ray, ultrasound, computed tomography (CT) and magnetic resonance (MR). Of the 37 cases reviewed, only ten presented changes in one or more of the imaging studies performed. the most common radiological finding was symmetric poly arthritis located at different sites. Other signs included avascular necrosis (late and early), inflammation and tendon and/or ligament rupture, nonerosive deforming arthropathies , soft tissue calcifications and arthritis (staphylococcal and tuberculous). A direct correlation was established between the anticardiolipin antibody titer, steroid doses and avascular necrosis. In SLE, radiologically detectable osteoarticular lesions are uncommon. Symmetric polyarthritis is the earliest lesion and that occurring most frequently. Other signs do not appear as often, with the exception of osteonecrosis, which usually occurs late. It developed early and was unusually aggressive in two youths with elevated anticardiolipin antibody titers and substantial systemic involvement in our series. The contributions of ultrasound and MR in the assessment of musculoskeletal involvement in SLE are especially relevant in the study of inflammations and tendon rupture and in the management of avascular necrosis, respectively. (Author) 17 refs.

  16. Surveillance and radiological protection in the Hot Cell laboratory; Vigilancia y proteccion radiologica en el Laboratorio de Celdas Calientes

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, J.M.; Torre, J. De la; Garcia C, M.A. [ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2004-07-01

    The Hot Cells Laboratory (LCC) located in the National Institute of Nuclear Research are an installation that was designed for the management at distance of 10,000 Curies of Co-60 or other radioactive materials with different values in activity. The management of such materials in the installation, implies to analyze and to determine the doses that the POE will receive as well as the implementation of protection measures and appropriate radiological safety so that is completed the specified by the ALARA concept. In this work it is carried out an evaluation of the doses to receive for the POE when managing radionuclides with maximum activities that can be allowed in function of the current conditions of the cells and an evaluation of results is made with the program of surveillance and radiological protection implemented for the development of the works that carried out in the installation. (Author)

  17. Radiological protection in Laguna Verde, the challenge of being better; Proteccion radiologica en Laguna Verde, el reto de ser mejores

    Energy Technology Data Exchange (ETDEWEB)

    Serrano R, H. [CFE, Central Laguna Verde, Proteccion Radiologica, Km 42.5 Carretera Cardel-Nautla, Veracruz (Mexico)]. e-mail: hsr98581@cfe.gob.mx

    2008-07-01

    The operation of the nuclear power plants in the last decade is based on the application of standard directed towards the excellence. The nuclear power plant of Laguna Verde (CNLV), is not the exception and in the 18 years of commercial operation, the safety culture has matured in the personnel. Standard and political implemented like in the control of dosimeter alarms, equipment condition, meetings pre-work, the practice of protection to the systems and the fuel, as well as the order and the cleaning have distinguished to the CNLV with other power stations. The sense of property of the personnel towards its work is fundamental for the achievement of results. It is reason for the present work to show since it has been gotten to obtain results directed to the excellence in the activities or of normal operation and recharge, where the security is the principle priority. (Author)

  18. Environmental Radiation Monitoring in PET-CT facilities; Vigilancia radiologica ambiental en instalaciones de PET-CT

    Energy Technology Data Exchange (ETDEWEB)

    Casa, M. A. de la; Gilarranz, R.; Adaimi, P.; Martinez, L. C.; Ruiz, M. A.; Rot, M. J.; Clemente, F.; Milanes, A.; Delgado, J. M.; Manzanas, M. J.

    2012-11-01

    We have made radiological surveillance measures in three PET-CT facilities during thirteen months. The results of our measures confirm the validity of the shielding calculation and safety studies performed in each one of the facilities. (Author) 3 refs.

  19. Role of magnetic resonance imaging in the diagnosis of spontaneous spondylodiscitis; Diagnosi radiologica della spondilodiscite. Ruolo della Risonanza Magnetica

    Energy Technology Data Exchange (ETDEWEB)

    Cusmano, F.; Calabrese, G.; Bassi, S.; Branislav, S.; Bassi, P. [Parma Univ., Parma (Italy). Ist. di Scienze Radiologiche

    2000-09-01

    Purpose of this work is to report the Magnetic Resonance Imaging (MRI) features of acute and chronic spontaneous spondylodiscitis as well as any as well as any typical patterns which can be useful for the differential diagnosis between pyogenic and tuberculous forms. Eleven patients affected with spontaneous spondylodiscitis were selected for the study; they were 7 men and 4 women ranging in age 33-87 years (mean: 64). Patients with a superconductive magnet at 1.5, with the following sequences: sagittal PD and T2-weighted TSE, sagittal T1-weighted SE, axial PD and T2-weighted TSE for the lumbar spine, axial T2-weighted GRE for the cervical and dorsal spine and axial and sagittal T1-weighted SE after contrast agent (gadolinium DTPA) injection. MR images were reviewed by three experienced radiologists and morphological and signal intensity changes of vertebral body and disk were recorded on a standard form. In 9 patients it was possible to compare MR to CT findings. Three patients had infectious diseases in other organs and 2 were diabetics. Biopsy was performed in two cases only and demonstrated Staphylococcus aureus in one and Mycobacterium tuberculosis in the other patient. MRI, allowed the correct diagnosis to be made in all cases, demonstrating the pathological involvement of the paravertebral structures and into the spinal canal earlier and more accurately than CT. A common finding in pyogenic and tuberculous spondylodiscitis was the low signal of the subcortical bone marrow on T1-weighted sagittal images, which enhanced after Gd-DTPA administration and became intermediate or high on T2-weighted images. Moreover, the steady high signal intensity of the disk on T2-weighted images and its contrast enhancement on T1-weighted images is typical for an acute inflammatory process. Based on our personal experience an literature data, it is believed that MRI is the most sensitive technique for the diagnosis of spondylodiscitis in the acute phase, whereas it is comparable to CT in the chronic stage of the disease. At present MRI does not allow to differentiate pyogenic from tuberculous forms. [Italian] Scopo di questo documento e' quello di caratterizzare con Risonanza Magnetica gli aspetti distintivi della spondilodiscite spontanea nelle fasi acuta e cronica e ricercare gli elementi semeiologici che possono essere d'aiuto per la diagnosi differenziale tra forme piogene e forme tubercolari. Sono stati rivalutati rispettivamente 11 pazienti (7 maschi e 4 femmine; eta' compresa tra 33 e 87 anni, media 64 anni) affetti da spondilodiscite spontanea osservati nel periodo 1994/99. Sono stati esclusi volutamente i pazienti con spondilodiscite imputabile a recente intervento chirurgico per ernia discale lombare. La RM e' stata condotta con un apparecchio da 1, 5 Tesla utilizzando sequenze TS pesata in DP e T2 e SE pesata in T1 sul piano sagittale, TSE in DP e T2 sul piano assiale per il segmento lombare, GRE pesata in T2 sul piano assiale per il segmento lombare, GRE pesata in T2 sul piano assiale per i segmenti cervicale e dorsale e SE pesata in T1 sui piani assiali dopo somministrazione di gadolinio. La revisione delle immagini cosi' ottenute ha riguardato le alterazioni morfologiche e del segnale del disco intersomatico e dei corpi vertebrali adiacenti interessati dal processo infettivo. In 9 pazienti e' stato possibile confrontare i reperti di RM con quelli di TC eseguita nei giorni immediatamente precedenti. In 3 pazienti erano presenti processi infettivi in altri organi e 2 erano diabetici. Solo in due casi e' stato eseguito l'esame batteriologico su biopsia discale che ha riscontrato la presenza di Stafilococcus aureus in uno e di Micobacterium tubercolosis nell'altro. In tutti i casi la RM ha permesso la diagnosi corretta dimostrando con precisione e piu' precisamente rispetto alla TC l'estensione del processo patologico nei tessuti molli paravertebrali e/o nel canale spinale. In particolare le alterazioni del segnale della spongiosa dei corpi vertebrali, ipointensa in T1 con aree di captazione di mdc e iperintensa in T2, e' un reperto costante nelle forme sia da piogeni che tubercolari. Inoltre l'aspetto RM del disco intersomatico, iperintenso in T2 e in T1, dopo somministrazine di gadolinio, e' da ritenersi altamente significativo per il processo flogistico in atto. Dall'analisi della casisitica e dei dati riportati nella letteratura la RM e' da considerarsi metodica di prima istanza per la diagnosi di spondilodiscite nella fase acuta, mentre nella fase di cronicizzazione del processo flogistico non sembra fornire elementi diagnostici superiori alla TC. Inoltre, la RM non consente attualmente di differenziare con sicurezza le forme da piogeni da quelle tubercolari.

  20. Helicobacter pylori e o idoso dispeptico : frequencia, aspectos clinicos, endoscopicos e histologicos : evolução da doença apos tratamento clinico

    OpenAIRE

    Telma da Silva Santos

    2002-01-01

    Resumo: Objetivo: Poucos são os trabalhos na literatura que abordam a dispepsia em pacientes idosos. Os objetivos deste trabalho foram: estudar a freqüência do H. pylori na população idosa com dispepsia funcional e ulcerosa; avaliar o comportamento clínico, aspectos endoscópicos e histotágicos do idoso; e, por, fim avaliar a evolução da doença após tratamento clínico. Métodos: Foram estudados pacientes no Ambulatório de Medicina Interna do Hospital Universitáriode Taubaté, no período de abril...

  1. El nacimiento de la patologia y su desarrollo en la region

    National Research Council Canada - National Science Library

    Giraldo-Giraldo, Cesar Augusto

    2011-01-01

    .... PALABRAS CLAVES Historia Anatomia patologica Patologia Patologia quirurgica CPC It is presente and overview of the emergence of concepts related to the pathology since the time of the Greeks and...

  2. Immunological Prevention of Spontaneous Mammary Carcinoma in Transgenic Mice

    Science.gov (United States)

    2001-08-01

    developed more slowly by transgenic FVB Anatomia Patologica, Ospedale S.S. Annunziata, Via Valignani, 66100 female mice carrying the wild-type proto...coopted (Pezzella et al., 1997). Anatomia Patologica. Ospedale SS. Annunziata, Via Valignani, 66100 Chieti, Italy. Fax: 39 0871 330471. E-mail: musiani...lo Studio e la Cura dei Tumori, Milan, Italy; and Reprints: Piero Musiani, G. d’ Annunzio University of Chieti, Anatomia Department of Experimental

  3. Correlation of clinico-pathologic and radiologic parameters of response to neoadjuvant chemotherapy in breast cancer

    Directory of Open Access Journals (Sweden)

    P Mukherjee

    2014-01-01

    Full Text Available Context: As of today, there is no validated standard method to assess clinical response of breast cancer to neo- adjuvant chemotherapy (NACT. Some centers use clinical dimensions while others use radiological measurements to evaluate response according to RECIST criteria. Aims: The aim was to correlate and compare the clinical, radiological, and pathological parameters for assessing the tumor response in patients of breast cancer receiving NACT. Settings and Design: Single institution, prospective nonrandomized study conducted over a 2-year period. Materials and Methods: Patients with diagnosed breast cancer were assessed for response to NACT prior to surgery using clinical and radiological techniques. This was correlated with pathological reponse which was assessed by measuring gross dimensions and Miller-Payne grading of response to chemotherapy. Statistical Analysis Used: Spearman′s rho nonparametric. RESULTS: Fifty two patients completed the evaluation (out of 313 cases of ca breast treated during the same period with a median age of 52.5 years. We noted a 26.9% clinical complete response (CR and 19.2% had pathological CR. Clinical evaluation had a sensitivity and specificity of 73.5% and 88.5% respectively compared to 14.2% and 100% respectively for radiological assessment. Conclusions: Clinical assessment of response to NACT shows a higher sensitivity compared to radiological assessment. However the overall low sensitivity and specificity rates of clinical assessment mandate a search for a better method of evaluation.

  4. [The characteristics of epilepsy in left-handed people (a clinico-electroencephalographic study)].

    Science.gov (United States)

    Dobrakhotova, T A; Boldyreva, G N; Bragina, N N; Zhavoronkova, L A; Savilov, V B

    1993-01-01

    As many as 16 epileptic patients with the sings of sinistrality in the motor and sensory spheres were examined. The authors demonstrate the clinical characteristics of epilepsy in the left handed, that distinguish them from the right-handed; dissimilarity of each psychopathological symptom and syndrome to their analogs in the right-handed, the occurrence of unusual phenomena, impossible in the right-handed. Depict specific features of the EEG that distinguish the patients examined from healthy right- and left-handed. The data obtained are interpreted as evidence that the clinical characteristics and the EEG appearance of epilepsy are determined to a considerable measure by the profile of asymmetry of each patient as well as by the fact that the left-handed may demonstrate diverse varieties of functional brain asymmetry, differing from the type of asymmetry of cerebral hemisphere functions common to all the right-handed in the maintenance of integral neuropsychic activity.

  5. Afericoes e exames clinicos realizados nos participantes do ELSA-Brasil

    Directory of Open Access Journals (Sweden)

    Jose Geraldo Mill

    2013-06-01

    Full Text Available Este artigo descreve os exames clínicos realizados no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil. Alguns deles (antropometria, pressão arterial e índice tornozelo-braquial já têm uso clínico consolidado. Outros, como a velocidade de onda de pulso, variabilidade da frequência cardíaca e medida da espessura médio-intimal de carótidas, carecem de valor de referência na população brasileira não doente e podem constituir preditores importantes de desfechos cardiovasculares. A medida da pressão arterial após manobra postural foi incluída no ELSA-Brasil porque foi pouco testada em estudos epidemiológicos. O ELSA-Brasil inovou na realização do índice tornozelo-braquial, ao usar um aparelho automático em substituição à coluna de mercúrio na medida da pressão arterial, e também na medida do diâmetro ântero-posterior do lobo direito do fígado pela ultrassonografia, proposta para avaliação quantitativa da doença hepática gordurosa não-alcoólica. Os participantes são indivíduos mais jovens (a partir dos 35 anos do que em outras coortes focadas no estudo da aterosclerose subclínica. A inclusão de indivíduos mais jovens e a diversidade dos exames realizados tornam o ELSA-Brasil um estudo relevante no contexto da epidemiologia brasileira e internacional.

  6. Clinico-bacteriological profile of primary pyodermas in Kashmir: a hospital-based study.

    Science.gov (United States)

    Bhat, Y J; Hassan, I; Bashir, S; Farhana, A; Maroof, P

    2016-03-01

    Pyodermas are a common group of infectious dermatological conditions on which few studies have been conducted. This study aimed to characterise the clinical and bacteriological profile of pyodermas, and to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection in primary pyodermas in a dermatology outpatient department in Kashmir. Methods We conducted a hospital based cross-sectional study in the outpatient Department of Dermatology, Sexually Transmitted Diseases and Leprosy of Shri Maharaja Hari Singh Hospital, Srinagar, Jammu and Kashmir, India. Patients presenting with primary pyodermas were included in the study. A detailed history and complete physical and cutaneous examination was carried out along with microbiological testing to find aetiological microorganisms and their respectiveantimicrobial susceptibility patterns. Antimicrobial susceptibility testing, including that for methicillin resistance, was carried out by standard methods as outlined in the current Clinical and Laboratory Standards Institute guidelines. Results In total, 110 patients were included; the age of the study population ranged from 3 to 65 years (mean age 28 years); 62% were male. Poor personal hygiene was noted in 76 (69%). Furunculosis (56; 51%) was the most common clinical presentation. Staphylococcus aureus was isolated in 89 (81%) of cases, and MRSA formed 54/89 (61%) of Staphylococcus aureus isolates. All MRSA strains were sensitive to vancomycin. Conclusion The prevalence of MRSA was high in this sample of communityacquired primary pyodermas. It is therefore important to monitor the changing trends in bacterial infection and their antimicrobial susceptibility patterns and to formulate a definite antibiotic policy which may be helpful in decreasing the incidence of MRSA infection.

  7. Clinico-epidemiological profile of malaria: Analysis from a primary health centre in Karnataka, Southern India

    Directory of Open Access Journals (Sweden)

    Ramachandra Kamath

    2013-01-01

    Full Text Available Malaria continues to be a major public health problem in India and worldwide. The present study was based on records from a primary health centre in Karnataka. Morbidity patterns and important features of malaria transmission specific to Udupi district were investigated. The incidence of malaria and various morbidity patterns during 2010 and 2011 were compared and analyzed. Factors such as rapid urbanization, increased construction activities and influx of migratory workers were highlighted as the leading causes for the advent of malaria in the area. Recommendations have been provided for implementation in the near future.

  8. Quiste sinovial en el tendon del musculo tibial posterior. Caso clinico, consideraciones biomecanicas y revision bibliografica

    National Research Council Canada - National Science Library

    Valero Salas, Jose; Gallart Ortega, Jose; Gonzalez Lopez, David

    2014-01-01

    Se presenta un caso de quiste sinovial localizado en la cara interna del tobillo derecho de una paciente que presenta pies pronados de articulacion subastragalina con el antepie patologicamente compensado en supinacion...

  9. Comparison of Clinico-Radiological Features between Congenital Cystic Neuroblastoma and Neonatal Adrenal Hemorrhagic Pseudocyst

    Energy Technology Data Exchange (ETDEWEB)

    Eo, Hong; Kim, Ji Hye; Jang, Kyung Mi; Yoo, So Young [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lim, Gye Yeon [St. Mary' s Hospital Catholic University, Seoul (Korea, Republic of); Kim, Myung Joon [Severance Hospital Yonsei University, Seoul (Korea, Republic of); Kim, Ok Hwa [Ajou University Hospital, Suwon (Korea, Republic of)

    2011-02-15

    To evaluate the radiological and clinical findings of congenital cystic neuroblastomas as compared with those of the cystic presentation of neonatal adrenal hemorrhage. We analyzed the US (n = 52), CT (n = 24), and MR (n = 4) images as well as the medical records of 28 patients harboring congenital cystic neuroblastomas (n = 16) and neonatal adrenal hemorrhagic pseudocysts (n = 14). The history of prenatal detection, location, size, presence of outer wall enhancement, internal septations, solid portion, calcification, turbidity, vascular flow on a Doppler examination, and evolution patterns were compared in two groups of cystic lesions, by Fischer's exact test. All (100%) neuroblastomas and three (21%) of the 14 hemorrhagic pseudocysts were detected prenatally. Both groups of cystic lesions occurred more frequently on the right side; 11 of 16 (69%) for neuroblastomas and 11 of 14 (79%) for hemorrhagic pseudocysts. The size, presence of solid portion, septum, enhancement, and turbidity did not differ significantly (p > 0.05) between the two groups of cystic lesions. However, tiny calcifications (n = 3) and vascular flow on color Doppler US (n = 3) were noted in only neuroblastomas. The cystic neuroblastomas became complex solid and cystic masses, and did not disappear for up to 90 days in the three following cases, whereas 11 of the 14 (79%) hemorrhagic pseudocysts disappeared completely and the three remaining (27%) evolved to calcifications only. Although the imaging findings of two groups of cystic lesions were similar, prenatal detection, the presence of calcification on initial images, vascularity on color Doppler US, and evolution to a more complex mass may all favor neuroblastomas

  10. 'Top of the basilar' syndrome: Clinico-radiological evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Sato, M.; Tanaka, S.; Kohama, A.

    1987-07-01

    Sixteen patients having infarction caused by circulatory disturbance at the top of the basilar artery, that is to say, the 'top of the basilar' syndrome, were studied, the diagnosis having been made by computerized tomography. Infarcts were widely distributed in each patient between the thalamus, midbrain, pons, cerebellum, and occipital lobe. Both thalami were involved in 7 cases. When the thalamus was involved bilaterally, the low density areas were symmetrical in size and localization. Angiography revealed that stenosis or occlusion by within a circle 2 cm in diameter surrounding the five-forked junction at the top of the basilar artery in 84.6%. Recanalization of the occluded artery occurred in 61.5%, suggesting that embolism played an important role in appearance of this syndrome.

  11. Aerosol, a health hazard during ultrasonic scaling: A clinico-microbiological study

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    Akanksha Singh

    2016-01-01

    Conclusions: The aerosols and splatters produced during dental procedures have the potential to spread infection to dental personnel. Therefore, proper precautions should be taken to minimize the risk of infection to the operator.

  12. Ensayo clinico para la enfermeria basada en evidencia: un desafio alcanzable

    OpenAIRE

    Medina,Eugenia Urra; Riveros,Edith Rivas; Pailaquilén,René Mauricio Barría

    2011-01-01

    El ensayo clínico aleatorio constituye el diseño de investigación más riguroso para estudios de intervenciones. En este tipo de estudios, el investigador está interesado en determinar si existe una relación causa-efecto entre un tratamiento y el resultado. Para ello debe comparar grupos de individuos que han sido asignados a recibir diferente nivel de exposición a la intervención, y así determinar si existe el efecto. Hoy en día, se reconoce como uno de los mejores estándares de evidencia par...

  13. Clinico-morphological features of the female genital tract: review of the literature

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    S. O. Nikogosyan

    2012-01-01

    Full Text Available In the review are provided data of the world literature on clinical and morphological features of neuroendocrine tumors of the female sexual sphere. Questions of pathogenesis and stages of development of new growths in embryogenesis considered. Historical references are given. Besides, in article questions of diagnostics and treatment of these tumors are taken up.

  14. Clinico-radiological features of subarachnoid hyperintensity on diffusion-weighted images in patients with meningitis

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    Kawaguchi, T., E-mail: madarafuebuki@yahoo.co.jp [Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Sakurai, K.; Hara, M. [Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Muto, M. [Department of Radiology, Okazaki City Hospital, Okazaki, Aichi (Japan); Nakagawa, M. [Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Tohyama, J. [Department of Radiology, Toyota-kai Medical Corporation Kariya Toyota General Hospital, Kariya, Aichi (Japan); Oguri, T. [Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Mitake, S. [Department of Neurology, Tosei General Hospital, Seto-shi, Aichi (Japan); Maeda, M. [Department of Radiology, Mie University School of Medicine, Tsu, Mie (Japan); Matsukawa, N.; Ojika, K. [Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Shibamoto, Y. [Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan)

    2012-04-15

    Aim: To investigate the clinical and radiological features of meningitis with subarachnoid diffusion-weighted imaging (DWI) hyperintensity. Materials and methods: The clinical features, laboratory data, and radiological findings, including the number and distribution of subarachnoid DWI hyperintense lesions and other radiological abnormalities, of 18 patients seen at five institutions were evaluated. Results: The patients consisted of eight males and 10 females, whose ages ranged from 4 months to 82 years (median 65 years). Causative organisms were bacteria in 15 patients, including Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Klebsiella pneumoniae, and Listeria monocytogenes. The remaining three were fungal meningitis caused by Cryptococcus neoformans. Subarachnoid DWI hyperintense lesions were multiple in 16 of the 18 cases (89%) and predominantly distributed around the frontal lobe in 16 of the 18 cases (89%). In addition to subarachnoid abnormality, subdural empyema, cerebral infarction, and intraventricular empyema were found in 50, 39, and 39%, respectively. Compared with paediatric patients, adult patients with bacterial meningitis tended to have poor prognoses (7/10 versus 1/5; p = 0.1). Conclusion: Both bacterial and fungal meningitis could cause subarachnoid hyperintensity on DWI, predominantly around the frontal lobe. This finding is often associated with poor prognosis in adult bacterial meningitis.

  15. Clinico-Immunological Analysis of Eggplant (Solanum melongena) Allergy Indicates Preponderance of Allergens in the Peel

    OpenAIRE

    2009-01-01

    Background Eggplant (Solanum melongena L.) is known to cause food allergy in some Asian countries but detailed studies on eggplant allergy are lacking. Objective The objective is to investigate sensitization to different parts of eggplant fruit, and detection of the allergens. Methods Six eggplant-allergic subjects were assessed for sensitization to eggplant (peel/pulp, and raw/cooked) by skin prick test, allergen-specific IgE, and immunoblots. Allergens were analyzed for glycoprotein nature ...

  16. Clinico-epidemiological study of pityriasis versicolor in a rural tertiary care hospital

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    Nazeema Tabaseera

    2014-08-01

    Full Text Available Background: The study was conducted to know the incidence of pityriasis versicolor in relation to age, sex, seasons and occupation in a rural set up. Methods: A total of 105 patients of pityriasis versicolor were clinically evaluated and confirmed mycologically at central lab in a tertiary care hospital in South India. The obtained data was recorded and analysed accordingly. Results: Male preponderance was observed in the study. Disease was most pronounced in younger age group (21-30 years especially students. 61.9% of patients sought medical advice on cosmetic grounds while 38% had pruritis. Chest was the commonest site of affection followed by neck and back. Conclusion: Early identification of the yeast by simple laboratory techniques would help prevent recurrences, systemic complications and cosmetological problems which are high especially among the students and younger age groups. [Int J Res Med Sci 2014; 2(4.000: 1438-1440

  17. EPIDEMIOLOGIC, CLINICO-MYCOLOGICAL ASPECTS OF FUNGAL INFECTIONS OF SKIN AND ITS APPENDAGES

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    Sheikh

    2014-04-01

    Full Text Available : BACKGROUND: The incidence of fungal infections is increasing at an alarming rate, presenting an enormous challenge to healthcare professionals. The prevalence of fungal infections seems to vary across the world because of various socioeconomic and cultural factors. AIM: This study was undertaken to analyze the epidemiological, clinical and mycological features of fungal infections of skin and its appendages. SETTINGS AND DESIGN: Over a period of 1 year (Jan 2010 to Jan 2011 Samples were collected from 402 clinically suspected cases of fungal infections attending outpatient dermatology department of a tertiary care hospital & medical college Kashmir. MATERIAL AND METHODS: Clinical samples (Skin, Hair and Nail from 402 clinically suspected cases were included in the study. All specimens were subjected to KOH examination and culture. Germ tube tests were performed on all growths identified as yeasts. RESULTS: 298 (74% samples showed evidence of fungal elements on direct microscopy, out of which 183 (61.40% turned out to be positive on culture. The most common dermatophyte isolated from different clinical samples were Trichophyton rubrum followed by Trichophyton mantagrophyte. CONCLUSION: The traditional methods of diagnosing fungal infections are still the best and important tool of diagnosis for the fungal infections in our setting. More studies are required in this part of the country.

  18. Clinico-microbiological study of dermatophytosis in a tertiary-care hospital in North Karnataka

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    Tonita M Noronha

    2016-01-01

    Full Text Available Context: The dermatophytoses constitute a group of superficial fungal infections of keratinized tissues, namely, the epidermis, hair, and nails. The distribution and frequency of dermatophytosis and their etiologic agents vary according to the geographic region studied, the socio-economic level of the population, the time of study, the climatic variations, the presence of domestic animals, and age. Aims: The present study was undertaken to assess the clinical profile of dermatophytic infections and to identify the causative fungal species in the various clinical presentations. Settings and Design: This was a hospital-based observational study. Materials and Methods: One hundred and fifty clinically suspected cases of dermatophytosis attending the outpatient department of a tertiary care hospital were included in the study. History was taken, general physical and cutaneous examination was done and details of skin lesions noted. Direct microscopy in 10% KOH (40% KOH for nail and fungal culture on SDA with 0.05% chloramphenicol and 0.5% cycloheximide was done in every case. Statistical Analysis Used: Statistical analysis was done using SPSS 17.0 software. Chi-square test and contingency coefficient test were used as significant tests for analysis. Results: Out of 150 patients studied, majority belonged to the age group of 21–30 years (22.7%. Male-to-female ratio was 1.63:1. Tinea corporis (24.7% was the most common clinical type observed. The overall positivity by culture was 40% and by direct microscopy was 59.3%. Trichophyton mentagrophytes was the predominant species isolated (48.3%. Conclusions: The present study reveals the changing trend in the prevalence of dermatophyte species in this part of Karnataka.

  19. Infusion sclerotherapy of microcystic lymphatic malformation: Clinico-radiological mid-term results

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    Lee, Jong Min; Lee, Seok Jong; Chung, Ho Yun; Huh, Seung; Kim, Hyung Kee [Dept. of urgery, Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2016-01-15

    A new sclerotherapy technique by slow mechanical infusion of sclerosant was validated for treatment of microcystic lymphatic malformation (mLM). Seventeen consecutive patients with mLM in extremities, cervicofacial area, and trunk were included (21.8 ± 21.5 years old, male:female = 5:12). All patients diagnosed as mLM were included. A total 4-32 mL 20-38% OK-432 solution was mechanically infused at the rate of 10 mL/hour into the mLM lesions. The treatment effect was estimated clinic-radiologically at the 4-month follow-up. Repeated sclerotherapy followed in the 6th month, if required. The therapeutic effect was evaluated using quantitative ultrasonographic examination including soft tissue thickness, cyst size and number. In 17 patients, total 31 infusion sclerotherapy sessions were performed and monitored for 425 ± 266 days. Fifteen patients (88%) showed improvement in all symptoms, signs, and ultrasonographic findings. In all cases, at least one finding presented improvement. The maximal number of cysts per ultrasonographic window and maximal diameter of the largest cyst decreased by 57 ± 57% and 51 ± 67%, respectively (p = 0.102, 0.004). The soft tissue thickness decreased by 18 ± 15% (p < 0.01). No significant complications such as distal lymphedema or skin necrosis occurred. Infusion sclerotherapy is a safe and effective treatment technique for microcystic LM, with improved outcome.

  20. CLINICO-EPIDEMIOLOGY AND THERAPEUTIC OUTCOME OF SNAKE BITE IN KONASEEMA REGION OF ANDHRA PRADESH

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    Sai Krishna

    2016-03-01

    Full Text Available INTRODUCTION Snake bite is a common and frequently devastating environmental and occupational problem, especially in rural areas of tropical developing countries. Snake bite incidence is high in Andhra Pradesh. With the onset of monsoon the incidence of snake bite used to increase. METHODS Present study is a retrospective study in which all the data of snake bite cases admitted in the Konaseema Institute of Medical Sciences was collected in last two years; details of the patient was obtained from bed head ticket. RESULTS In two years of data collection, 46 snake bite cases are found as per our record. Out of 46 patients, twenty seven were male and nineteen were female. Maximum twenty two (22 patients were between ages 20 to 40 years. Out of forty six patients, forty four recovered and only two patients died, cause of death was acute pulmonary oedema with cardiac arrhythmia. DISCUSSION Most of the patients were given ASV (anti-snake venom, out of that only four patients developed reaction to ASV. Most of the patients who have received ASV were recovered. Only two deaths were reported which was due to acute pulmonary oedema with cardiac arrhythmia. CONCLUSION Awareness and education about snake is required.

  1. Variant lumbrical musculature of the left hand: Clinico-anatomic elucidation.

    Science.gov (United States)

    Singh, S; Loh, H K; Mehta, V

    2016-12-01

    Human hand is haughtily described in literature as 'revolution in evolution'. Lumbricals form an intricate part of its musculature playing a vital role in complex digital movements. By virtue of their origin from the volar aspect of palm and their insertion onto the dorsal aspect to the extensor digital expansion of the digits, lumbricals display complex actions flexing the metacarpophalangeal joint and extending the interphalangeal joints. Such manoeuvres of the digits are vital for skilful and precision movements. During routine dissection of the teaching program of undergraduate medical students, unusual origin and morphology of all the four lumbrical muscles in the left hand of a male cadaver was observed. Clinicians and hand surgeons should be aware of its variations while designing and dealing with hand surgeries. An attempt has been made to comprehend its clinical, embryological and phylogenetic aspects. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  2. Clinico-pathological Correlation in Diagnosis of Hansen's Disease: A Histopathologist's Perspective

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    Reshma Gopal Kini

    2017-06-01

    Full Text Available Objectives: Hansens’s disease follows a chronic course and though curable causes considerable degree of disability and deformity. Key to managing leprosy is it’s early diagnosis and treatment with multidrug regimen. Histopathological evaluation of skin biopsies play crucial role in the correct diagnosis of clinically ambiguous cases. Moreover classifying lesions by the Ridley-Jopling(RJ system gives personalized information about the immulogical status of the individual and also aids in placing the patient in the correct treatment category. Materials and methods: Skin biopsies obtained from newly diagnosed cases of leprosy were included. Paraffin embedded sections stained with hematoxylin- eosin and Fite-Farracco were evaluated for features confirming leprosy and further categorized as per the RJ system. Sensitivity, specificity and concordance rates were looked for. Results: A total of 93 cases were studied after excluding those which had a component of reaction. Among the clinically suspected cases 93% of the biopsies were positive for leprosy. Sensitivity of clinical diagnosis ranged from 60% for borderline(BB to 100% for histioid leprosy. Specificity ranged from 84.5% for borderline tuberculoid (BT to 100% for neuritic leprosy. The agreement between histopathological and clinical diagnosis was more than 90% in all the subclasses except for BT which showed agreement in about 82% of the cases. Two of the cases were recategorized into multibacillary type of leprosy based histopathological evaluation. Conclusion: Confirmation of leprosy by examination of skin biopsy before starting the patient on long term multidrug therapy is invaluable. Experience of the leprologists and adherence to histopathological criteria as per the Ridley Jopling classification yield excellent concordance rates. [J Interdiscipl Histopathol 2017; 5(2.000: 48-54

  3. Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City.

    Science.gov (United States)

    Lobo, A C; Pai, R R; Gautam, K; Kuruvila, M

    2014-01-01

    Hansen's Disease (HD) presents itself in different forms depending on the individual's immune status, and based on this Ridley-Jopling classified the disease into five sub-groups. The aim of this study was to evaluate the role of histopathology and bacteriological index (BI) in accurate staging of HD with clinical correlation. Fifty HD patients with clinical diagnosis confirmed by histopathology were included. Patients in reaction and on treatment were excluded. Case records and histopathological slides were viewed and BI was recorded. In 10/50 cases, a diagnosis of HD was made or suspected, but were not clinically classified. In these, histopathology proved useful in diagnosis and classification. Indeterminate HD was the most common histopathological diagnosis (6 cases). The remaining 40 patients, were clinically classified using the Ridley-Jopling classification, as Indeterminate Leprosy (IL) in 10/40 (25%), Tuberculoid Leprosy (TT) 5/40 (12.5%), Borderline Tuberculoid (BT) 16/40 (40%), Borderline Lepromatous (BL) 4/40 (10%) and Lepromatous Leprosy (LL) 5 (12.5%). HD was common in males with male to female ratio of 1.66:1 and affected the younger individuals (maximum in 21 to 30 years). On histopathology BT was the most common type (40%) followed by IL (27.5%), BL (12.5%), TT (10%) and LL (10%). No case of Mid-Borderline (BB) type was diagnosed clinically or histopathologically. Overall concordance between clinical and histopathological diagnosis was 65% (26/40 cases) and for each type was IL = 80%, TT = 20%, BT = 75%, BL = 50% and LL = 60%. Where classification seemed difficult as in cases of BT and BL, II played an important role. The overall concordance between clinical classification and histopathological diagnosis of DO is 65% in this study. Th *discordance that is observed is between BT and TT, the paucibacillary type and BL andILL the multibacillary type and hence the treatment is not affected. Overall, IL was a common diagnosis on histopathology in this study'(11/40 cases and 6/10 cases). If clinically warranted, a repeat deeper punch of skin biopsyrmay be required for a proper categorization of the cases.

  4. Clinico-psychological analysis of systematic (vestibular and nonsystematic (psychogenic vertigo, therapy optimization

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    Elena Mikhailovna Illarionova

    2011-01-01

    Full Text Available Objective: to study the clinical and psychoemotional characteristics in patients with systematic and nonsystematic vertigo and to optimize therapy. Patients and methods. The clinical features were analyzed in 25 patients with systematic vertigo and 25 patients with psychogenic vertigo. Their psychoemotional sphere was studied using the Beck depression inventory, the Spielberger-hanin personality- and situation-related anxiety inventory, and the vestibular inventory. Results. There were statistically significant clinical differences and a higher degree of anxiety-depressive disorders in the patients with psychogenic vertigo. Drug therapy in combination with stabilometric platform exercises based on the biological feedback principle was stated to be effective in patients with different types of vertigo, in those with psychogenic dizziness in particular.

  5. The pathophysiology of Lennox-Gastaut syndrome – a review of clinico-electrophysiological studies

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    Yagi Kazuichi

    2015-06-01

    Full Text Available Introduction. Lennox-Gastaut syndrome (LGS is a type of therapy-resistant epileptic syndrome. Since the establishment of our Epilepsy Center in 1975 we have performed many studies to assess the clinical symptoms, seizure manifestations, sleep and long-term follow-up of the clinical course and changes on electroencephalographs (EEGs in patients with LGS.

  6. Clinico-electrophysiological profile and predictors of functional outcome in Guillain-Barre syndrome (GBS).

    Science.gov (United States)

    Verma, Rajesh; Chaudhari, Tejendra Sukdeo; Raut, Tushar Premraj; Garg, Ravindra Kumar

    2013-12-15

    Guillain-Barre syndrome (GBS) is an acute polyradiculoneuropathy with varied severity of presentation. To study the clinical and electrophysiological profile of patients with GBS and to determine the factors associated with poor functional outcome and need for mechanical ventilation. It was a hospital-based prospective observational study. 90 patients with GBS diagnosed as per Asbury and Cornblath criteria were enrolled and followed up for 6 months. Various epidemiological, clinical and electrophysiological parameters were evaluated. Hughes motor scale was used to measure functional outcome. Factors associated with poor functional outcome and need for mechanical ventilation were determined. 90 patients (56 males; 34 females; mean age of 29.3±15.2 years) were enrolled in this study. Amongst these 6 (6.7%) patients died during in-hospital stay. Antecedent infection was present in 29 (32.2%), autonomic dysfunction in 31 (34.4%), bulbar palsy in 21 (23.3%), neck flexor weakness in 52 (57.8%). 60 cases (66.7%) were of axonal variety and 30 (33.3%) of demyelinating variety. On univariate analysis, predictors associated with poor functional outcome at 6 months were autonomic dysfunction (p=0.013), neck flexor weakness (p=0.009), requirement of ventilatory assistance (p=<0.001), MRC sum score<30 on admission (p=<0.001) and axonal pattern on electrophysiological assessment (p=<0.001). On multivariate analysis, MRC sum score<30 on admission (p=0.007) and axonal pattern on electrophysiological assessment (p=<0.001) were independently associated with poor functional outcome at 6 months. Factors associated with need for mechanical ventilation were presence of autonomic dysfunction (p=<0.001), cranial nerve palsy including facial palsy (p=<0.001) and bulbar palsy (p=0.002), neck flexor weakness (p=<0.001), low MRC sum score (<30) (p=0.001), and low proximal CPN CMAP amplitude to distal CPN CMAP amplitude ratio (p=0.042); none of them being significant on multivariate analysis. Detailed evaluation of the clinical and electrophysiological profile may help in predicting the functional outcome and need for mechanical ventilation in patients with GBS. © 2013.

  7. Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics.

    Science.gov (United States)

    Gatselis, Nikolaos K; Zachou, Kalliopi; Koukoulis, George K; Dalekos, George N

    2015-01-07

    Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology characterized by hypergammaglobulinemia, autoantibodies detection and interface hepatitis. Due to the absence of specific diagnostic markers and the large heterogeneity of its clinical, laboratory and histological features, AIH diagnosis may be potentially difficult. Therefore, in this in-depth review we summarize the substantial progress on etiopathogenesis, clinical, serological and histological phenotypes of AIH. AIH has a global distribution affecting any age, both sexes and all ethnic groups. Clinical manifestations vary from asymptomatic to severe or rarely fulminant hepatitis. Hypergammaglobulinemia with selective elevation of IgG is found in most cases. Autoimmune attack is perpetuated, possibly via molecular mimicry, and favored by the impaired control of T-regulatory cells. Histology (interface hepatitis, emperipolesis and hepatic rosette formation) and autoantibodies detection although not pathognomonic, are still the hallmark for a timely diagnosis. AIH remains a major diagnostic challenge. AIH should be considered in every case in the absence of viral, metabolic, genetic and toxic etiology of chronic or acute hepatitis. Laboratory personnel, hepato-pathologists and clinicians need to become more familiar with disease expressions and the interpretation of liver histology and autoimmune serology to derive maximum benefit for the patient.

  8. CLINICO-HAEMATOLOGICAL STUDY OF CHRONIC KIDNEY DISEASE IN A TERTIARY CARE CENTRE

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    Parvathi Gorla

    2016-08-01

    Full Text Available BACKGROUND Chronic kidney disease (CKD is a major public health problem causing significant morbidity and mortality worldwide. Diabetes mellitus (DM and hypertension are common causes and anaemia is a common complication. It is important to identify the cause and complication, to treat it and prevent its progression to end-stage renal disease (ESRD. AIM To identify the haematological pattern in chronic kidney disease patients and to study the clinical presentation. MATERIALS AND METHODS 72 cases of CKD were studied for a period of 6 months and thorough assessment of clinical features and haematological examinations were done. RESULTS CKD is observed in all age groups and predominantly in older age group greater than 50 yrs., with male preponderance. DM and hypertension are common causes. 89% of the patients presented with anaemia and 4 cases of sickle cell anaemia were observed. Neutrophilic leucocytosis was seen in 29.2% and thrombocytopenia in 8.3% of cases. CONCLUSION CKD is seen in all age groups with a male predominance, common in older age group, anaemia being the most common and important haematological complication. Few cases of sickle cell anaemia (SCA were seen presenting with CKD. Knowledge and treatment of these conditions has proved to improve the quality of life.

  9. Enfermeiro Clinico Especialista: um modelo de pratica avancada de enfermagem em oncologia pediatrica no Brasil

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    Carla goncalves Dias

    2013-12-01

    Full Text Available O objetivo deste artigo é relatar a experiência de implantação do modelo de prática avançada de enfermagem por meio da incorporação do enfermeiro clínico especialista na composição do quadro de enfermagem. As autoras apresentam o conceito desse modelo e descrevem seu processo de implantação em uma instituição de referência no cuidado à criança e ao adolescente com câncer da cidade de São Paulo, Brasil. Na avaliação das enfermeiras clínicas especialistas, o principal resultado obtido com a adoção do modelo refere-se ao fortalecimento do papel do enfermeiro como profissional de referência para a articulação das diferentes demandas de cuidado à criança, ao adolescente e ao adulto jovem com câncer e sua família. Também destacam a satisfação dos usuários com o estreitamento da relação paciente, família e enfermeira clínica, em todas as etapas do processo de cuidar.

  10. Clinico-morphological changes and diagnosis of animal poisoning with mercury preparations

    Energy Technology Data Exchange (ETDEWEB)

    Tishkov, A.I.

    1976-01-01

    This paper examines animal poisoning with mercury compounds used to dress seeds. Chickens, guinea pigs, and mice were fed plants grown from seeds dressed with mercury compounds. The chickens exhibited stomatitis, pharyngitis, esophagitis, and leukocytosis. The guinea pigs and mice exhibited a biological accumulation of mercury.

  11. Clinico-microbiological study of diabetic limb amputations in a tertiary care hospital in North India

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    Rajpal Singh Punia

    2015-04-01

    Full Text Available The diabetic population faces 80% increased risk of cellulitis, 4-fold increased risk of osteomyelitis and 2-fold risk of both sepsis and death caused by infections.Study objectives.The present study was carried out to assess the clinical aspects and microbiological profile of organisms isolated from 25 patients undergoing diabetic limb amputations.Materials and Methods. In 25 diabetes persons who underwent limb amputation, grading of ulcers was done according to Wagner system. Material was stained with Gram stain. Potassium hydroxide wet mounts were also studied. Culture was done in blood agar, MacConkey agar, Sabouraud dextrose agar tube slants and brain heart infusion broth and examined for growth. The histopathology sections were also studied and special stains were done.Results. Of 25 cases, 16 were males and 9 were females. The age ranged from 30 to 90 years (mean: 58±10.91. Majority of ulcers were grade 3. Osteomyelitis was seen in 13 (52% cases; acute in 2 (8%, chronic in 3 (12% and acute exacerbation of chronic osteomyelitis in 8 (32% cases. On culture Proteus mirabilis was isolated in majority of cases followed by Escherichia coli. In 20 cases more than one bacterium were isolated. Candida was cultured in 8 cases followed by Trichosporon in 2 and Fusarium in one case. On histopathology Candida was seen in 3 cases, while one case showed spores of Trichosporon. 80% cases with osteomyelitis had polymicrobial infection.Conclusions. The isolation of etiologic agent helps in administering appropriate antibiotic regimens, thus reducing the problem of multidrug resistance, morbidity and surgical limb amputations in patients suffering from diabetes mellitus.

  12. CLINICO-PATHOLOGICAL STUDY OF INFLAMMATORY SYNOVIAL LESIONS OF KNEE JOINT

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    Mamatha

    2015-12-01

    Full Text Available INTRODUCTION Synovial joints account for most of body’s articulation and characterised by wide range of almost frictionless movements. Synovium is the central area of pathology in a number of inflammatory joint diseases. Joint effusions present as diagnostic challenge to physicians and need careful evaluation and interpretation of both clinical and laboratory findings to make accurate diagnosis and avoid unnecessary hospital stay. Joint effusions present as diagnostic challenge to physicians and requiring careful evaluation and interpretation of both clinical and laboratory findings to make accurate diagnosis to avoid unnecessary hospital stay. AIM OF THE STUDY Is to study the diagnostic features joint effusion in cases of inflammatory synovitis of the knee joint. MATERIALS AND METHODS Prospective study was done over a period of two years in the Department of Pathology in a tertiary care hospital. Joint fluid was obtained by arthrocentesis in patients with joint effusions. Gross, microscopic, microbiological and biochemical parameters were examined in 50 samples of synovial fluids with synovial biopsy correlation. RESULTS Out of 50 cases, 20 cases were rheumatoid arthritis, 12 cases of chronic inflammatory arthritis not specified. 10 cases tuberculous arthritis, septic arthritis in 7 cases and gout 1 case. CONCLUSION Combination of clinical, radiological, serological, biochemical and microbiologic findings along with synovial fluid and biopsy findings help in diagnosis of specific inflammatory lesions of the synovium and treating the particular condition.

  13. CLINICO - COLONOSCOPIC AND HISTOMORPHOLOGICAL SPECTRUM OF COLONIC DISEASES IN AN ACADEMIC TERTIARY CARE CENTRE

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    Rangaswamy

    2014-01-01

    Full Text Available AIMS : Colonoscopic examination is important in the diagnosis and treatment of various suspected colonic diseases. The procedure is used to look for early signs of colorectal cancer. The aims of this study were to correlate colonoscopic findings with the histopat hological diagnosis obtained and also to study histopathological features of colonoscopic biopsy specimens. MATERIAL AND METHODS : The study was a retrospective analysis of data between April 2012 and June 2013. 507 colonoscopies were performed during this period. Colonoscopic biopsies showed significant findings on histopathology in 107 patients and were included in the study. The more severe diagnosis was used for analysis when there was more than one colonoscopic finding. All the colonoscopic biopsy speci mens were immediately fixed and then routinely processed and embedded. Serial sections were prepared and stained with Hematoxylin and Eosin. Special stains like PAS and Van Gieson stains were used wherever necessary. RESULTS : The clinically significant fin dings seen on colonoscopy included colorectal cancers , IBD , colonic tuberculosis , strictures , solitary rectal ulcers and polyps. Other relevant findings seen were GI bleed and extrinsic compressions from contiguous structures. Among 107 biopsies , 82 biopsies were non - neoplastic , 25 biopsies were neoplastic. Overall 17 malignant lesions were picked up on histopathology. No significant histopathological findings were detected in bio psies from clinically not releva nt colonoscopies. CONCLUSION : Chronic di arrhea and bleeding per rectum were the most common presenting complaints. IBD and malignancy were detected in a significant number of the biopsies. Histopathological diagnosis correlated well with the colonoscopy diagnosis offered. Colonoscopic screening can detect early colonic neoplasms in asymptomatic patients.

  14. Insights into thermoregulation: A clinico-radiological description of Shapiro syndrome.

    LENUS (Irish Health Repository)

    Pazderska, Agnieszka

    2013-06-15

    Shapiro syndrome is a rare entity, comprising a triad of recurrent hypothermia, hyperhidrosis and congenital agenesis of the corpus callosum. Fewer than 50 cases have been described, almost invariably in patients presenting in childhood or early adulthood. We present a case of an 80year old woman presenting with recurrent bouts of shivering, sweating and profound malaise, who sought medical attention because the frequency and severity of attacks worsened in her later years. MRI Brain demonstrated agenesis of the corpus callosum; a rigorous work-up excluded other causes for her symptomatology. The intricate interplay of neuronal networks involved in thermoregulation remains to be fully elucidated and as such, little is known about the pathophysiological mechanisms underlying the clinical manifestations of Shapiro syndrome. We present novel data from FDG-PET imaging of our patient, demonstrating hypermetabolism in a number of brainstem and cerebellar regions during the symptomatic phase. These findings imply that aberrant thermoregulation in Shapiro syndrome involves a number of structures remote from the callosal region. We also present neuropsychometric findings in our patient, of which there have been no reports to date. We postulate that the ageing brain may be more susceptible to the paroxysmal neurochemical fluxes implicated in the syndrome.

  15. CLINICO-PATHOLOGICAL PROFILE OF MASTALGIA IN AND AR OUND KANPUR

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    Katiyar

    2012-10-01

    Full Text Available Mastalgia is a general term used to describe numbe r of conditions, in which pain is present in one or both breast (s. It is the commone st breast symptom presenting in surgical clinics. Most patients come to the Doctor, because o f the fear of malignancy. However the ratio of benign to malignant cases in clinics is 10:1. S imply 3 major type of breast pain may be recognized Cyclical, Non-cyclical pain; extra mammar y pain Aim of This study was focused to study the cause of mastalgia i.e. to correlate the clinical diagnosis to the histological examination and conservative management. Female patients between 15 years – 55 years of age with complain of pain in breast were accepted for study. A thorough general as well as local examination was done. Mammography was done in patient above 35 years of age. The treatment protocol is decided, all patient coming to OPD in first 15 Days of month were given Evening primrose oil in dose of 500 mg 2 cap thrice a day for a period of two months. All those coming in next half were treated with danazol 200mg /day for two months. Patients were called to OPD on every 15 th day to assess the response and also to check that t he patient was appropriately following the given treatment . The exact cause of mastalgia is still unknown. Severe mastalgia can however disrupt normal life by interfering with sleep, relationship with husband and children and may also affect occupation of working women. In our study we have tried to treat patient with cycli cal mastalgia and true mammary non cyclical mastalgia patients using, Evening primrose oil (EPO and danazol as line drugs. Those not responding were treated with Tamoxifen or Bromocripti ne randomly (II nd line therapy. Danazol and EPO were used again by crossover as III rd line therapy. Mastalgia is a common symptom reported in surgical OP D. The highest incidence of mastalgia was found in patients of 36-45 age groups. Cyclical mastalgia was the commonest type constituting 63.75%. Mastalgia is more commonly see n in left than right breast (40% vs 28.75%. Mastalgia was more commonly observed in mu ltiparous we conclude that Danazol seems to be best available drug for both cyclical a nd non cyclical mastalgia. However, Tamoxifen approaches the same efficacy in both groups; in fact i t has a better response in non cyclical mastalgia group. EPO is better drug for young and fo r women who do not want their period to be disturbed

  16. [Features of episodes of mental disorders in chronic renal insufficiency (clinico-morphologic study)].

    Science.gov (United States)

    Korkina, M V; Tsivil'ko, V S; Tsivil'ko, M A

    1976-01-01

    The authors studied the traits of psychotic attacks in 40 patients with terminal stages of chronic renal insufficiency. They were expressed in atypical delirious, delirio-amentive and amentive conditions. 8 cases were studied morphologically. The pathological process in the brain was characterized as toxico-dyshomeostatic encephalopathy. The pathogenesis of such disorders is discussed.

  17. Clinico-Epidemiological Profile And Factors Affecting Severity Of Atopic Dermatitis In North Indian Chilldren

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    Sarkar Rashmi

    2004-01-01

    Full Text Available Atopic dermatitis (AD is a chronic, relapsing dermatitis commonly affecting children. Various epidemiologic factors and clinical patterns of the same were evaluated in 125 patients out of 418 attending the pediatric dermatology clinic over a period of 11/2 years. Of these, 26 were infants (upto 1 year of age and 99 were children. Mean duration of the disease in the infantile group was 3 months while in the childhood group it was 6 years. In the infantile group, family history of atopy was found in 11 patients (42.3%, while in the childhood group 35 (35.35% had family history of atopy, 7 (7.07% had personal history of atopy and 2 (2.02% had both personal and family history of atopy. The infantile group had more frequent facial involvement and acute type of eczema, while in the childhood type, site involvement was less specific and chronic type of eczema was more frequent. Most of the patients had mild to moderate degree of severity of the disease.

  18. Neurofibromatosis type 1: clinical and radiological aspects; Neurofibromatose tipo 1: aspectos clinicos e radiologicos

    Energy Technology Data Exchange (ETDEWEB)

    Muniz, Marcos Pontes; Souza, Antonio Soares [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Imagem]. E-mail: depimagem@famerp.br; Ferraz Filho, Jose Roberto Lopes [Faculdade de Medicina de Sao Jose do Rio Preto (Famerp), SP (Brazil). Hospital de Base. Unidade de Ressonancia Magnetica; Zanusso, Silvia Helena [Centro de Pesquisa e Atendimento em Nerofibromatose (CEPAN), Sao Jose do Rio Preto, SP (Brazil); Bertelli, Erika Cristina Pavarino [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Unidade de Pesquisa em Genetica e Biologia Molecular; Bertollo, Eny Maria Goloni [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Disciplina de Genetica

    2006-04-15

    Neurofibromatosis type 1 is a genetic disease with an incidence of approximately 1 in 3,000 people, characterized mainly by systemic and progressive involvement, manifesting by physical deformity and compromising of neurological functions. The diagnosis of the neurofibromatosis type 1 must be performed the earliest possible through clinical exams and familiar history. The use of imaging diagnosis as radiography, computed tomography, and magnetic resonance imaging is valuable for diagnosis, treatment, follow-up of patients and control of lesions, preventing complications. In this study we describe the clinical and radiological aspects of the neurofibromatosis type 1, considering clinical features, genetics, bone alterations in chest, vertebral column, upper and lower limbs, and craniofacial abnormalities. (author)

  19. Incappucciamento Indiretto con Mineral Trioxide Aggregate (Mta: Caso Clinico e Follow-up

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    Francesco Riccitiello

    2014-11-01

    Risultati e conclusioni: A causa di alcuni problemi di salute, la bambina è tornata dopo 6 mesi. È stata osservata la formazione di tessuto duro e il controllo rx mostrava una chiara evidenza di formazione radicolare. Abbiamo eseguito il restauro finale di 36 con materiali compositi. Al controllo dopo 6 mesi e 7 anni non risultano segni clinici e radiografici di patologia pulpare o radicolare. In conclusione, l’MTA sembra essere un materiale utilizzabile con successo per il mantenimento della vitalità pulpare. Inoltre offre un’ottima impermeabilità, anche nei casi in cui ha avuto luogo una perdita di integrità del materiale di otturazione provvisorio.

  20. Factores Etiologicos de la Hipersensibilidad Primaria y Secundaria en Tejido Dentario. Protocolo de Manejo Clinico.

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    Norberto Calvo Ramírez

    2011-10-01

    Full Text Available La hipersensibilidad en tejido dentario, es una patología que día a día aumenta su frecuencia en población adulta, quizás no es una causa primaria de consulta odontológica pero se podría clasificar como secundaria, debido a que es de tipo multifactorial. En la actualidad toda la información sobre la  hipersensibilidad dentinal es reportada de la  experiencia clínica pero no de estudios clínicos reales los cuales todavía son débiles o ausentes; en cuanto al tratamiento de esta, se evidencia que el primer paso es modificar la dieta y crear  hábitos mediante el uso de sustancias para tal fin como una buena alternativa. Debido a esto se hace necesaria la compilación de las diferentes causas y la creación de un protocolo de manejo clínico ante la presencia de esta dolencia; también es importante prevenirla, por eso se percibe la necesidad de  crear medidas de prevención para aplicarlas en la consulta odontológica. 

  1. A clinico-etiological study of cervical lymphadenopathy in children with special reference to ultrasonography

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    Tripathi Virendra Nath

    2010-09-01

    Full Text Available Objectives: The aim of this study was to evaluate the etiological factors for cervical lymphadenopathy in children and the role of ultrasonography (USG in diagnosis.Methods: A total of 200 children of significant cervical lymphadenopathy between 3 months to18 years were prospectively included in a tertiary referral hospital. All subjects were evaluated by history, examination, hemogram, chest X-ray, mantoux test, fine needle aspiration cytology (FNAC, acid-fast bacillus (AFB staining, ultrasonography (USG of lymph node. Open lymph node biopsy, bone marrow examination, serological tests were optional.Results: A total of 84 subjects (42% identified as benign reactive, 80 (40% as tuberculosis, 20 (10% chronic lymphadenitis, 12 (6% non-Hodgkin and 4 (2% Hodgkin’s lymphoma by USG. However, on USG among 84 subjects of benign reactive lymphadenopathy, 60 (71.4% were having features of benign reactive lymph node, remaining 24 (28.6% have normal sonogram; out of 80 subjects of tuberculosis lymphadenitis 66 (82.5% have features of tuberculosis and rest14 (17.5% have nonspecific ultrasound changes; among 16 subjects of lymphoma, 10 (62.5% have features of malignancy, rest 6 (37.5% have nonspecific changes in USG examination. Male to Female ratio was1.68:1. Cervical lymphadenopathy was most prevalent in 6 to 10 years age group.Conclusion: Reactive lymphadenitis due to underlying acute bacterial or viral infection was the commonest cause of significant cervical lymphadenopathy in children and ultrasonography is a good noninvasive diagnostic modality, but requires other tests for definitive diagnosis.

  2. CLINICO-PATHOLOGY AND ULTRASTRUCTURAL ETUDY OF NEPHROPATHY CHANGES DUE TO LUPUS ERYTHEMATOSIS DISSEMINATUS

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    A. Modjtabai

    1969-01-01

    Full Text Available Nephrotic syndrome _ Nephrotic syndrome is found in 30% of all of the cases of systematic LE. Nephropathy Changes Due to Lupus Erythematosus 21 (15,16 in peripheral blood may confirm definitively lupus cryhcrornatosus. Additional serological evidence such as hyper g-gJobu":nemia, and 19_s-g_ globulin may then positively confirm the (17. Supporting evidence of 11 specific type of glomerular substantiates prior clinical and paracIinical evidence: The foregoing ultrasnucturat chnracteristtcs are then seen to represent an additional check of routine diagnostic procedures In addition observed permits an opportunity to• correlate• min~te changes with known biochemical changes previosly A. Modjtabai et at Diagnostically the presence of kidney disease and the presence of L.E. Urine albumin _ The appearance of urine albumin to the extent of 8-10 mgm.mil is a sign of kidney damage. This may be accompanied by acute kidney inadequacy, cyrtitis with fever and pain. There may be a varying globulin excretion which is taken by some as a precursor of ensuing damage. This point, of course, has been debated. When clinical and paraclinical signs indicate LE. definitive conclu, sions may be. reached utilizing electron microscopy. The disease occurs more frequently in women than in men and especially among young people. More than one person in a family may bevaffectcd leading to the assumption that the trait is inherited. The hereditary nature of the disease, however, has not been definitely estab., lishcd. Basically the disease appears to original as an abnormal imrnu., nological reaction to external or internal causes or perhaps even auto.; immunological. Causative or aggravating factors may be long exposure to sunlight, and ultraviolet rays which may free lysozyrnes or other proteolytic enzymes which attack the ground substance of the cell membranes of the endothelium. Drugs such as penicillin, sulfonamide and hydralyzin have caused allergic reactions resulting in lupus although differences of opinions exist as to the roles these drugs may play, as a causative agent since in some patients a withdrawal at medication results in accessation of the symptoms but in other patients there is no apparent change. It has been proposed that the above mentioned drugs react with body proteins to form the antibodies causative .of the disease. Infections also have been mentioned as a causative factor as well as rheumatic factors and rheumatic arthritis. 20 Differences exist as to the physical manifestation of the L. E. syndrome however certain basic symptoms appear in all cases of the disease. These basic cyrnptorns may not be accompied by other peripheral manifestations,

  3. Efficacy and tolerance of papain gel with conventional drilling method: a clinico-microbiological study.

    Science.gov (United States)

    Goyal, P A; Kumari, R; Kannan, V P; Madhu, S

    2015-01-01

    Conventional methods of caries removal are commonly associated with pain, fear and discomfort. Chemomechanical methods were introduced to instill a positive dental attitude. Agents like GK-101, Caridex, Carisolv did not prove effective alternatives owing to their high cost, need of special instruments and taste of chlorine. A new chemomechanical agent, Papacarie®, has been introduced to overcome these deficiencies. This study was aimed to compare the effectiveness and tolerance of Papacárie® with the conventional method. 25 children with at least two primary teeth with broad cavitated occlusal or cervical lesion were selected. One carious tooth from each patient was randomly treated with each of Papacarie® and conventional drilling method, one after the other. Time taken for caries excavation, child's pain perception, change in anxiety levels, microbial flora and child's preference of treatment were recorded separately for both the methods. Although the mean time taken for caries removal by the Papacarie® method was slightly longer (P≯0.05) but it led to reduction in pain and anxiety (premoval.

  4. Clinico-etiological profile of childhood stroke in a Tertiary Care Hospital in Eastern India

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    Chaitali Patra

    2015-01-01

    Full Text Available Background: The clinical pattern and etiology of stroke may vary over time or with geographical location. In Asian countries, specific etiology and outcome of childhood stroke have been rarely reported. Objective: To determine the clinical and etiological pattern of childhood stroke and their outcome in a Tertiary Care Center. Materials and Methods: This study was conducted in a Tertiary Care Hospital of Kolkata over a period of 3 years. All children from 6 months to 12 years, diagnosed as childhood stroke by radio-imaging were included in our study. Children presenting with paraplegia/paraparesis were excluded. Etiologies were determined on the basis of clinical examination, related blood investigations and radio-imaging findings. Data gathered from the stroke patients were entered into a preformed proforma and appropriate statistical analyses were done. Result: Most commonly found clinical presentation was hemiparesis (70.6%. Next in place was a seizure (61.8% and alteration of consciousness (58.8%. The most common etiology of childhood stroke in our hospital was found to be an intracranial infection (41.2%, followed by vascular etiology. Stroke was ischemic in nature in 91.2% of cases. Among the clinical features, vomiting, alteration of sensorium, and fever were significantly (P < 0.01 more in infectious cases of stroke, but hemiparesis was significantly (P < 0.05 more common in noninfectious etiology. Most of the cases of noninfectious etiology (95% completely recovered without any persistent neurodeficit or mortality. Conclusion: Intracranial infection is the commonest etiology of stroke in pediatric patients presenting at our hospital. Commonest type is an ischemic stroke. The most of the patients completely recovered from the acute neurological insult after proper and timely management.

  5. Assessment of Streptococcus mutans in healthy versus gingivitis and chronic periodontitis: A clinico-microbiological study

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    Sneha Dani

    2016-01-01

    Full Text Available Background: Dental caries and periodontal disease are most common oral diseases. Streptococcus mutans are considered to be the major pathogens in initiation of dental caries. Evidence shows that periodontal disease and caries share a number of contributory factors. Thus in view of these findings it would be worthwhile to examine whether Streptococcus mutans persist within the saliva and subgingival environment of the periodontitis patients and to determine whether there is any association between Streptococcus mutans colonization, pH of saliva and sub-gingival plaque pH in periodontal diseases before therapy. Methods: The study comprises of 75 subjects aged between 20-70 years, reporting to department of Periodontology, KLEs Institute of Dental Sciences, Bangalore. Subjects were divided into 3 groups of 25 each. Group 1 – Healthy controls, Group 2 – Gingivitis Group, 3 – Chronic periodontitis. Unstimulated saliva was collected in sterile container and immediately pH was evaluated. Subgingival plaque samples were collected from four deepest periodontal pockets in chronic periodontitis and from first molars in healthy subjects using 4 sterile paper points. In gingivitis subjects samples were collected from areas showing maximum signs of inflammation. All paper points and saliva samples were cultured on mitis salivarius agar culture media with bacitracin for quantification of the Streptococcus mutans colonies. Results: Increased colonization of Streptococcus mutans was seen in chronic periodontitis subjects both in saliva and sub-gingival plaque samples. There was also a positive correlation seen with the periodontal parameters. Conclusion: More severe forms of periodontal disease may create different ecological niches for the proliferation of Streptococcus mutans.

  6. [Clinico-histologic-morphometric correlations in pulmonary arteries among patients with heart malformations ].

    Science.gov (United States)

    Fischbach, H; Hoffmeister, H M; Hoffmeister, H E; Apitz, J; Schmidt, C

    1982-01-01

    To improve the evaluation of grades of pulmonary vascular lesions in congenital heart malformations, we studied the extent to which there is a measurable relationship between pressure conditions in the pulmonary circulation and the area of the media in small and medium-sized pulmonary arteries, and the possibility of a correlation between the subjective evaluation of grades of hypertensive pulmonary vascular lesions according to Heath and Edwards (1958). Material and methods. The lungs in 68 children (mean age, 22.7 months) with congenital malformations of the heart or great vessels resulting in pulmonary hypertension were examined. The lungs were fixed in a 4% formalin solution passed via the trachea under a constant filling pressure of 150 cm H2O. Peripheral as well as central tissue was removed from all lobes of the lungs; the specimens were stained with Elastica-van Gieson. The extent of hypertensive pulmonary vasculopathy was staged, without knowledge of the pressure conditions, according to the grading system developed by Heath and Edwards. The diameter and the area of all muscular arteries with diameters smaller or larger than 100 micron were measured using a semiautomatic measurement device for quantitative morphometric analysis (MOP/AM 01). Cardiac catheter values were available for all cases. The quotient of systolic pressures in the pulmonary artery and the aorta was taken as the measure of hemodynamic conditions in the pulmonary circulation. The Pearson-Bravais correlation coefficient (r) was computed from the respective area quotient and the corresponding pressure values. In addition, the coefficient of determination (r2) and regression functions were determined. Results. A linear correlation (r = 0.70) exists between the pressure quotient (Psyst. pulm. art./ Psyst. aorta) and the vessel area quotient (media area/total area). The correlation is expressed by the following functions: x = 1.89 y - 0.08 y = 0.26 x + 0.24 Using the Heath and Edwards grading, the following frequencies were obtained: Grade 0: 21, Grade I: 7, Grade II: 16, Grade III: 15, Grade IV: 6, and 3 children were undeterminable. No relationship exists between the grades and certain heart malformations. In spite of the fact that hypertensive vasculopathy becomes progressively more severe as the child grows older, we found four cases of Grade IV in children under the age of one. On the whole, a comparison of the measured area quotients and the Heath and Edwards grading showed a good correlation. Although we considered only pressure quotients and no other hemodynamic parameters, conclusions can be drawn about the operability of congenital heart malformations based on these findings. Using measured pressure values, the morphologic state of the pulmonary arteries can be approximately evaluated.

  7. [Problem of clinico-pathogenetic analysis and correction of behavior disorders in adolescents].

    Science.gov (United States)

    Semke, V Ia; Avdeenko, A A; Babushkina, L U; Bokhan, N A; Vas'kova, G A

    1982-01-01

    On the basis of integrated clinical, dynamic, and neurophysiological examinations of 542 children and adolescents with behaviour deviations a high (54.05%) percentage of psychic anomalies (primarily, characterological ones) was discovered. The structure of the delinquent behaviour was found to be the most complicated in children and adolescents taught at special schools for juvenile offenders. In adolescents registered at the Inspection on Minors' Affairs this structure was of a more isolated character. An important role of combinations of constitutional-biological, exogenous-organic, and negative microsocial factors in the genesis of the juvenile delinquency is demonstrated. Clinical and laboratory examinations of "difficult" adolescents with distinct neuropsychic disturbances revealed substantial shifts in their cortical neurodynamics and the functioning of chemoreactive systems. On the basis of the data obtained a complex of differentiated therapeutic and hygienic measures aimed at attaining a regression of the borderline personality pathologies has been developed.

  8. Encefalitis a citomegalovirus en un paciente inmunocompetente: análisis clinico, neuropatologico y ultraestructural

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    Salamano Ronald

    2001-01-01

    Full Text Available Las encefalitis por citomegalovirus en pacientes inmunocompetentes son excepcionales, siendo un patógeno reconocido en pacientes inmunodeprimidos (SIDA, transplantados. Se reporta el caso clínico de una encefalitis por Citomegalovirus en un adulto joven, sin evidencia de enfermedad inmunosupresora, cuyo diagnóstico fue posible mediante la detección de ADN viral en la biopsia cerebral. Se describen además las singularidades clínicas de este caso y los hallazgos de la anatomía patológica y de la microscopía electrónica comparándolos con los reportados en pacientes inmunodeprimidos.

  9. Cuidado clinico em enfermagem: desenvolvimento de um conceito na perspectiva de reconstrucao da pratica profissional

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    Lia Carneiro Silveira

    2013-09-01

    Full Text Available A Enfermagem é uma práxis que tem se definido a partir de diferentes planos epistemológicos. Sua historicidade é marcada por construções e desconstruções. Neste percurso, o cuidado e a sua prática clínica assumem constituições atravessadas pelos interesses sociais, econômicos e ideológicos de cada época. Objetivamos, neste texto, refletir sobre a construção do plano conceitual do cuidado clínico em enfermagem, em uma perspectiva que permita o deslocamento do modelo epistêmico tradicional pautado no referencial biomédico e no modelo cartesiano de sujeito. Trata-se de uma reflexão teórica em que desenvolvemos este conceito, partindo das concepções adotadas nas linhas de pesquisa do Mestrado Acadêmico em Cuidados Clínicos em Saúde da Universidade Estadual do Ceará. Finalizamos com a apresentação da proposta do Mestrado Acadêmico em Cuidados Clínicos da Universidade Estadual do Ceará, exemplificando como este conceito tem sido potencializador de suas produções na área da saúde e da enfermagem.

  10. Clinical and tomographic aspects of macular microholes; Aspectos clinicos e tomograficos dos microburacos maculares

    Energy Technology Data Exchange (ETDEWEB)

    Novelli, Fernando Jose de [Hospital de Olhos Sadalla Amin Ghanem, Joinville, SC (Brazil)], e-mail: Fernando.novelli@gmail.com; Maia Junior, Otacilio de Oliveira [Fundacao Monte Tabor, Salvador, BA (Brazil). Hospital Sao Rafael; Nobrega, Mario Junqueira [Universidade da Regiao de Joinville (UNIVILLE), Joinville, SC (Brazil); Garrido Neto, Theodomiro [Universidade do Estado do Amazonas (UEA), Manaus, AM (Brazil); Takahashi, Walter Yukihiko [Universidade de Sao Paulo (USP), SP (Brazil). Hospital das Clinicas. Dept. de Oftalmologia

    2009-07-01

    Purpose: To describe the clinical aspects and evaluate optical coherence tomography of macular microholes. Methods: Seven patients were assessed (8 eyes) with microholes of the macula. All patients underwent complete eye examination, fundus photography, fluorescent angiography and OCT-3 imaging. Results: Ages ranged from 26 to 69 years. Six patients were female (85.7%) and five of them had microhole in the right eye. The presenting symptom was decrease in visual acuity (71.3%) and central scotoma in (14.3%). Five eyes (71.4%) had no defects shown by fluorescent angiography. A defect in the outer retina was demonstrated in all eyes on optical coherence tomography. The lesions were nonprogressive. Conclusion: Macular microholes are small lamellar defects in the outer retina. The condition is nonprogressive, generally unilateral and compatible with good visual acuity. Fundus biomicroscopy associated with an optical coherence tomography are the main elements in the diagnosis and study of this pathology. (author)

  11. Assessment of Streptococcus mutans in healthy versus gingivitis and chronic periodontitis: A clinico-microbiological study

    Science.gov (United States)

    Dani, Sneha; Prabhu, Ashwin; Chaitra, K. R.; Desai, N. C.; Patil, Sudhir R.; Rajeev, Ranjan

    2016-01-01

    Background: Dental caries and periodontal disease are most common oral diseases. Streptococcus mutans are considered to be the major pathogens in initiation of dental caries. Evidence shows that periodontal disease and caries share a number of contributory factors. Thus in view of these findings it would be worthwhile to examine whether Streptococcus mutans persist within the saliva and subgingival environment of the periodontitis patients and to determine whether there is any association between Streptococcus mutans colonization, pH of saliva and sub-gingival plaque pH in periodontal diseases before therapy. Methods: The study comprises of 75 subjects aged between 20-70 years, reporting to department of Periodontology, KLEs Institute of Dental Sciences, Bangalore. Subjects were divided into 3 groups of 25 each. Group 1 – Healthy controls, Group 2 – Gingivitis Group, 3 – Chronic periodontitis. Unstimulated saliva was collected in sterile container and immediately pH was evaluated. Subgingival plaque samples were collected from four deepest periodontal pockets in chronic periodontitis and from first molars in healthy subjects using 4 sterile paper points. In gingivitis subjects samples were collected from areas showing maximum signs of inflammation. All paper points and saliva samples were cultured on mitis salivarius agar culture media with bacitracin for quantification of the Streptococcus mutans colonies. Results: Increased colonization of Streptococcus mutans was seen in chronic periodontitis subjects both in saliva and sub-gingival plaque samples. There was also a positive correlation seen with the periodontal parameters. Conclusion: More severe forms of periodontal disease may create different ecological niches for the proliferation of Streptococcus mutans. PMID:27994423

  12. Oligoanalgesia in pronto soccorso: da un audit retrospettivo a un percorso clinico-assistenziale

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    Edoardo Pennacchio

    2012-08-01

    Full Text Available Background. Nonostante il dolore acuto rappresenti il sintomo più frequente di presentazione in pronto soccorso, numerosi studi hanno riportato un’elevata prevalenza di oligoanalgesia (insufficiente riconoscimento o trattamento del dolore in questo setting assistenziale. Obiettivi. Stimare la frequenza della oligoanalgesia nel pronto soccorso dell’Azienda Ospedaliera San Carlo di Potenza e identificare le cause per correggere il problema. Metodi. Un audit team multidisciplinare ha effettuato un audit retrospettivo sui primi 3000 accessi in pronto soccorso del 2011, con interrogazione del sistema informatico aziendale. Sono stati esclusi i pazienti di età < 12 anni e quelli con dolore toracico o addominale, cefalea severa, politrauma. Risultati. Sono stati identificati 580 pazienti con dolore potenzialmente trattabile (M/F 333/247; età media 44,5 anni; 11,7% con dolore severo, 88,3% con dolore moderato. In tutti i pazienti è stata valutata l’intensità del dolore con scala verbale; sono stati trattati con analgesici il 33,8% dei pazienti con dolore grave e il 18,9% di quelli con dolore moderato; sono stati usati i seguenti farmaci: paracetamolo, ketoprofene, tramadolo, diclofenac, tiocolchicoside, fluoroglucinolo, lorazepam, betametasone, acido acetilsalicilico, metilprednisolone, ossigeno; il timing medio di somministrazione degli anagesici è stato di 90’ nei pazienti con dolore severo e di 93’ nei pazienti con dolore moderato; il 39% dei pazienti con dolore severo è stato trattato dopo oltre 20’ dall’accettazione; il 50,5% dei pazienti con dolore moderato è stato trattato dopo oltre 60’ dall’accettazione; nessuno dei pazienti ha ricevuto una rivalutazione del dolore; al 59,4% dei pazienti con dolore severo e al 63,5% di quelli con dolore moderato sono stati prescritti analgesici alla dimissione. Limiti. Non è stato possibile valutare l’impatto di interventi non farmacologici abitualmente utilizzati, quali l’applicazione di ghiaccio e l’immobilizzazione dei pazienti con trauma degli arti. Conclusioni. Anche nel nostro pronto soccorso l’oligoanalgesia è un problema frequente. L’analisi delle cause ha suggerito possibili interventi di miglioramento, i cui effetti potranno essere valutati con uno studio prospettico.

  13. EVALUACION DEL COMPORTAMIENTO BIOLOGICO, CLINICO Y MICROBIOLOGICO DE RESINAS DE ULTIMA GENERACION

    OpenAIRE

    Velermoro, Victor; Profesores de la Facultad de Odontología. UNMSM.; Moromi, Hilda; Profesores de la Facultad de Odontología. UNMSM.; Gálvez, Luis; Profesores de la Facultad de Odontología. UNMSM.; Salcedo, Doris; Profesores de la Facultad de Odontología. UNMSM.; Paz F., Juan José; Profesores de la Facultad de Odontología. UNMSM.; Quintana, Carmen; Profesores de la Facultad de Odontología. UNMSM.; Ayala, Gerardo; Profesores de la Facultad de Odontología. UNMSM.

    2014-01-01

    An study of three clases of resins of last generation was done evaluating the clinical conduct histological, microbiological and microfiltración through electronical microscopic concluting that the clinical answer in the three tippies of resins in casties of 3 mm of intensity were not present, in histologic grade you cannot see qualitive changes, in the microbiological aspect it was verified y kal the efect antimi crobianie is only produced with direct contact with the resens through the shap...

  14. Sensibilidad y resistencia en el antibiograma del Staphylococcus aureus en pacientes del Hospital Clinico Viedma

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    Gustavo Favio Lazo Arispe

    2013-12-01

    Full Text Available La resistencia bacteriana a los antibióticos es un problema de salud, ya que conlleva la utilización de fármacos más complejos y muy poco accesibles. El objetivo principal de este trabajo es conocer la sensibilidad y resistencia de Staphylococus aureus a los antibióticos, en pacientes que asistieron a Emergencias del Hospital Clínico Viedma. Mediante la realización de un estudio de tipo descriptivo-prospectivo-transversal; se tomó muestras por conveniencia no probabilística de pacientes con heridas infectadas y quemaduras sobre infectadas que asistieron a Emergencias del Hospital Clínico Viedma. Se encontró que el Staphylococcus aureus demostró una sensibilidad del 100% a la vancomicina, siendo este fármaco de mayor utilidad, pero este microorganismo demostró una mayor resistencia a la amoxicilina y oxacilina siendo estos fármacos de menor utilidad. Stafilococcus aureus presenta día a día mayor resistencia a antibióticos comúnmente usados para su tratamiento, presentando sensibilidad a fármacos que antes no se usaban en su tratamiento.

  15. CLINICO – EPIDEMIOLOGY OF U TI IN UNDER 5 YEARS OF AGE IN CHILDREN

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    Sonali

    2015-06-01

    Full Text Available Urinary tract infections (UTIs are a common , potentially serious , and often occult bacterial infections of childhood . UTI is more frequent in females than males at all ages with the exception of the neonatal period . Urinary tract infections imply invasion of urinary tract by pathogens which may involve the upper or lower urinary tract depending on the infection in kidney , bladder and urethra . OBJECTIVES: To determine the incidence of UTI in febrile children be low 5years of age and to know the aetiological profile of UTI among the same group of children with fever . METHODS: This cross sectional observational study included all febrile children from one month to 5years of age , admitted in Pediatric ward in MGM Me dical College , Kishanganj , Bihar . RESULTS: Overall incidence rate of UTI in the present study was 6% with maximum incidence in children <2years of age . Among culture positive cases majority (50% grew E . coli . DMSA revealed renal cortical scarring in 42 . 8 5% cases following UTI . CONCLUSION: From the present study it can be concluded that UTI is a common bacterial infection in infant and children . Rapid evaluation and treatment of UTI is important to prevent renal parenchymal damage and renal scarring or ren al failure .

  16. Meesmann Corneal Dystrophy; a Clinico-Pathologic, Ultrastructural and Confocal Scan Report

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    Mohammad-Ali Javadi

    2010-01-01

    Full Text Available Purpose: To report the microstructural features of Meesmann corneal dystrophy (MCD in two patients. Case Report: The first patient was a 10-year-old boy who presented with bilateral visual loss, diffuse corneal epithelial microcystic changes, high myopia and amblyopia. With a clinical impression of MCD, automated lamellar therapeutic keratoplasty was performed in his left eye. Histopathologic examination of the corneal button disclosed epithelial cell swelling and cyst-like intracytoplasmic inclusions. The cells contained moderate amounts of periodic acid-Schiff-positive and diastase-sensitive material (glycogen. Transmission electron microscopy revealed numerous vacuoles and moderate numbers of electron-dense membrane-bound bodies in the cytoplasm, similar to lysosomes, some engulfed by the vacuoles. The second patient was a 17-year-old female with a clinical diagnosis of MCD and episodes of recurrent corneal erosion. On confocal scan examination of both corneas, hyporeflective round-shaped areas measuring 6.8 to 41.4 μm were seen within the superficial epithelium together with irregular and ill-defined high-contrast areas in the sub-basal epithelial region. The subepithelial nervous plexus was not visible due to regional hyperreflectivity. Conclusion: This case report further adds to the microstructural features of Meesmann corneal dystrophy and suggests confocal scan as a non-invasive method for delineating the microstructural appearance of this rare dystrophy.

  17. Bacterial Viability within Dental Calculus: An Untrodden, Inquisitive Clinico-Patho- Microbiological Research

    Science.gov (United States)

    Jain, PK; Kumra, Madhumani; Rehani, Shweta; Mathias, Yulia; Gupta, Ramakant; Mehendiratta, Monica; Chander, Anil

    2016-01-01

    Introduction Chronic inflammatory periodontal diseases i.e. gingivitis and periodontitis are one of the most common afflictions faced by human beings. Dental plaque, which is a pool of pathogenic microorganisms, remains to be current mainstay in etiopathogenesis. Dental calculus, which is a mineralized product of this plaque remains ignored and is considered merely as an ash heap of minor significance. However, the intriguing array in disease etiopathogenesis bulldozed researchers to suspect the role of calculus in disease chrysalis but still the viability of bacteria inside calculus and thus its pathogenicity remains an intricacy; the answer to which lies in the Pandora’s Box. Aim The present study was undertaken to investigate the viability of bacteria within dental calculus along with their identification. Also, to classify dental calculus on the basis of mineralization and to observe the variation of viable microflora found in dental calculus with the extent of mineralization and disease severity. Materials and Methods A total of 60 samples were obtained, by harvesting two samples of supragingival calculus from each patient having chronic inflammatory periodontal disease. These samples were divided into two groups (Group A and Group B). Samples of Group A were kept non-irradiated and samples of Group B were exposed to UV radiation. The samples were categorized into less, moderately and highly mineralized according to the force required for crushing them. All the crushed calculus samples were then divided into three parts. These were used for dark-field microscopy, gram staining and bacterial cultures. Bacterial identification of the cultures obtained was also carried out by performing various biochemical assays. Results The present study revealed the presence of motile spirochaetes within the samples under dark-field microscope. Gram staining revealed presence of numerous gram positive cocci and gram negative bacilli. Bacterial cultures showed growth of variety of aerobic and capnophilic microorganisms. Conclusion The present study concludes the presence of viable aerobic and capnophilic bacteria inside dental calculus which may reside within the lacunae and channels in the calculus. PMID:27630958

  18. Progressive anarthria with secondary parkinsonism: a clinico-pathological case report.

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    Broussolle, E; De Tommasi, M; Mauguière, F; Chazot, G

    1992-01-01

    The pathological process and lesion topography in patients with the syndrome of progressive aphasia are heterogeneous and few necropsy examination cases have been investigated. This is a case report of a 53 year old right handed man with progressive anarthria and secondary Parkinsonism over a period of six years. Positron emission tomography (PET) showed a decreased cerebral blood flow and metabolism in the frontal cortex, which was more pronounced on the left. Neuropathology disclosed a spon...

  19. Progressive anarthria with secondary parkinsonism: a clinico-pathological case report.

    Science.gov (United States)

    Broussolle, E; Tommasi, M; Mauguière, F; Chazot, G

    1992-07-01

    The pathological process and lesion topography in patients with the syndrome of progressive aphasia are heterogeneous and few necropsy examination cases have been investigated. This is a case report of a 53 year old right handed man with progressive anarthria and secondary Parkinsonism over a period of six years. Positron emission tomography (PET) showed a decreased cerebral blood flow and metabolism in the frontal cortex, which was more pronounced on the left. Neuropathology disclosed a spongiform vacuolation in layer II of the frontal cortex, mostly in the Broca area, and neuronal loss in the substantia nigra. This original case reinforces the view that there are different entities of the syndrome of progressive aphasia which can be identified on the basis of clinical, neuroimaging and anatomical data.

  20. Mielopatia necrotizante e neoplasias: registro clinico-patologico de dois casos

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    Marcos R. G. de Freitas

    1983-06-01

    Full Text Available São relatados dois casos de mielopatia transversa subaguda associada a tumores malignos. O primeiro paciente apresentava neoplasia de células reticulares histiocitárias e o segundo, carcinoma renal. Os autores fazem revisão dos casos similares descritos na literatura. As alterações anátomo-patológicas medulares encontradas foram semelhantes às descritas nos relatos prévios, sendo que no primeiro caso havia também intenso infiltrado inflamatório perivascular e a presença de astrócitos bizarros. Tais alterações encontradas sugerem ser esta afecção de natureza viral.

  1. Schwannoma of the sino-nasal tract: a rare clinico-pathological entity revisited

    Institute of Scientific and Technical Information of China (English)

    Nadia Shirazi; Saurabh Varshney; Meena Harsh; S. S Bisht

    2012-01-01

    Schwannomas are benign neoplasms arising from Schwann cells of the peripheral, cranial and autonomic nerves. We report a case of schwannoma in the sino-nasal tract, a very rare site of tumour origin with unusual pseudoangiomatous histopathological changes, which we came across in a 22 years male with progressive nasal obstruction.

  2. Isolated intramedullary tuberculoma of the dorsal cord:a rare clinico-radiological entity

    Institute of Scientific and Technical Information of China (English)

    Sumeet Bhargava; Rajul Rastogi; Gaurav Jindal; Amrit Kumar Singh; Vaibhav Rastogi

    2010-01-01

    Tuberculous infection manifesting as an isolated intramedullary tuberculoma of the spinal cord is distinctly unusual. We report a case of a 35 year old woman presenting with an insidious onset of myelopathy, where MRI showed characteristic imaging findings suggestive of intramedullary tuberculosis.

  3. A clinico-epidemiological study of ulcerative sexually transmitted diseases with human immunodeficiency virus status.

    Science.gov (United States)

    Mehta, Bhavesh

    2014-01-01

    Genital ulcerative diseases are a major public health problem. The advert of human immunodeficiency virus (HIV)/AIDS over the past 25 years has deepened the scope of morbidity, mortality, and various forms of clinical presentations of sexually transmitted diseases (STDs). A total of 50 cases having Genital ulcerative diseases and STD reporting to STD clinic during the period of the year from November 2005 to December 2006 were included and detailed history and clinical examination were carried out and provisional diagnosis is made. Laboratory confirmation of clinically diagnosed cases was done using laboratory tests such as S. HIV, venereal disease research laboratory, Tzanck smear, gram stain, and Giemsa stain. In the present study, the incidence of herpes progenitalis was (38%) followed by primary syphilis (32%), chancroid (26%), lymphogranuloma venereum (02%), and genital scabies (02%). HIV sero-positivity was detected in 12% (n = 6) cases. HIV was found to be more common among genital ulcer disease patients, especially syphilis and genital herpes.

  4. Demographic and Clinico-Epidemiological Features of Dengue Fever in Faisalabad, Pakistan

    Science.gov (United States)

    Raza, Faiz Ahmed; Rehman, Shafiq ur; Khalid, Ruqyya; Ahmad, Jameel; Ashraf, Sajjad; Iqbal, Mazhar; Hasnain, Shahida

    2014-01-01

    This cross-sectional study was carried out to explore the epidemiological and clinical features of dengue fever in Faisalabad, Pakistan during 2011 and 2012. During the study period, anti-dengue IgM positive cases were reported in the post-monsoon period during the months of August–December. Certain hotspots for the dengue infection were identified in the city that coincide with the clusters of densely populated urban regions of the city. Out of total 299 IgM positive patients (male 218 and female 81); there were 239 dengue fever (DF) and 60 dengue hemorrhagic fever (DHF) patients. There was decrease in the median age of dengue patients from 31 years in 2011 to 21.5 years in 2012 (pdengue fever. PMID:24595236

  5. Clinic-Radiological Study of facial paralysis. Estudio clinico-radiologico de la paralisis facial

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    Olier, J.; Bacaicoa, M.C.; Guridi, J.; Gil, J.L.; Elcarte, F.; Delgado, G. (Hospital de Navarra Pamplona (Spain))

    1992-01-01

    We have gathered 159 cases of facial paralysis from recent records in our hospital, including paralyses of central as well as peripheral origin, and presenting as the only symptom or as one of several major symptoms of the discomfort of each patient. Sixty-four percent of them were studied by CT scan and/or MR, confirming the existence of alterations in the pathway of nerve pair VII in 50% of the patients who underwent radiological study. Idiopathic facial paralysis was the most common type (42% of the total); while tumors and post-traumatic findings were the most constant radiological findings. From the analysis of the data, the importance of the clinical criteria for selection of the patients in the study and the protocol for radiological diagnosis employed can be deduced. (author)

  6. The effects of a dentifrice containing propolis on Mutans Streptococci: a clinico-microbiological study.

    Science.gov (United States)

    Mohsin, S; Manohar, B; Rajesh, S; Asif, Y

    2015-01-01

    Propolis is a natural resinous mixture produced by honeybees, which exhibits anti-microbial, anti-inflammatory, cytostatic and cariostatic properties. The aim of the study was to evaluate the anti-bacterial efficacy of a propolis based dentifrice on Mutans Streptococci colonizing the oral cavity of young patients using Dentocult® SM strip mutans test. Screening of 367 male subjects within the age group of 7-12 years was carried out. A total of 30 children were included in the study. They were instructed to use a Propolis dentifrice (Probee,™ Quasi-Medical Products, Seoul Propolis) daily for three minutes over a period of four weeks. Plaque and salivary samples were collected at baseline, 1(st) week, 3(rd) week and 4(th) week and were analyzed for Mutans Streptococci count using Dentocult® SM strip Mutans kit (Orion Diagnostica Oy, Finland). Student paired t-test and Friedman test were used for statistical analysis. It was unveiled that mean Mutans streptococci count at 1(st) week and 4(th) week, showed significant reduction (p≤0.0001), compared to baseline scores. Using Friedman's test, statistically significant difference was found between baseline and 1(st) week, 3(rd) week and 4(th) week follow up (P dentifrice reduces in-vivo microbial load in microenvironments especially against Mutans streptococci in the oral cavity of young patients. Thus, it's potential to be inculcated and used as an alternative measure to prevent dental caries can be considered and further investigation involving greater number of participants is recommended.

  7. A study of clinico-demographic profile of patients with dissociative disorder

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    SK Shah

    2013-09-01

    Full Text Available Objectives To study the clinical and socio demographic profile of patients with dissociative disorder and their comorbid mental illness. Materials and methods Fifty-one patients of dissociative disorder presenting to emergency and outpatient department of Psychiatry at College of Medical Sciences Teaching Hospital during the period from Jan to March 2012 were included. International statistical classification of diseases and related health problems tenth edition, diagnostic criteria for research (ICD-10, DCR was used. Results Out of 51 patients, the majority 24 (47.1%, were in the age group 15-29. However the age of presentation ranged from 9-45 years. The females were more, 44 (86.3% as compared to males 7 (13.7%. The majority of patients had low level of education with none of the patients having education above intermediate level. The majority of patients, 27(52.9% belonged to lower middle class. 49% of the patients presented with dissociative convulsions, 15.7% with dissociative motor disorders, 15.7% with dissociative stupor, 11.8% with dissociative anesthesia and sensory loss and 7.8% with trance and possession disorder. Depressive illness was found co-morbid with dissociative disorder in 33.3%, borderline personality disorder in 9.8% and histrionic personality disorder in 7.8%. There was history of immediate stressful events that supposedly precipitated the event in 76.5%. Conclusion Dissociative disorder mainly affects young female of lower socio-economic and educational status with history of immediate stressful life events precipitating the illness. Journal of College of Medical Sciences-Nepal, 2012, Vol-8, No-3, 30-35 DOI: http://dx.doi.org/10.3126/jcmsn.v8i3.8683

  8. Evaluation of melatonin levels in saliva in periodontal health and disease: A clinico-biochemical study

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    Nilkanth Mhaske

    2010-01-01

    Full Text Available Background: Melatonin, a secretory product of the vertebrate pineal gland, activates several elements of the immune system that reduce tissue destruction during the inflammatory response, either directly by scavenging free radical, reactive oxygen species and reactive nitrogen species or indirectly by modulating the action of agents such as cytokines and adhesion molecules, which contribute to the advance of cell damage. Aim: The aim of this study was to evaluate melatonin levels in saliva in periodontal health and disease. Materials and Methods: This study was conducted on a total of 20 patients with healthy periodontium and 20 patients each with mild, moderate and severe periodontitis who were patients in the Department of Periodontics, Rural Dental College and Hospital, Loni. The salivary levels of melatonin were assayed using ELISA, a competitive immunoassay using a capture antibody technique. Results: We observed that the periodontitis sufferers had a significantly lower melatonin level than the healthy subjects. Conclusion: Consequently, the reduction in the saliva production with higher age and the decreased melatonin production in older adults reflected in low salivary melatonin levels predispose these individuals to an increased risk of developing oral and periodontal disease.

  9. A COMPARITIVE STUDY OF CLINICO-RADIOLOGICAL OUTCOME: DHS VERSES PFLCP IN INTERTROCHANTRIC FRACTURES OF FEMUR

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    Vanamali B

    2015-11-01

    Full Text Available INTRODUCTION: There have been many case series advocating the potential benefits of PFLCP for fixation of intertrochanteric fractures. But these studies are lacking in terms of guidelines regarding the type of fractures in which PFLCP has an upper hand over the gold standard implant that is the DHS. Moreover there have been very few control studies comparing these two implants. Therefore, we performed a case control study to assess: (1 If PFLCP offers better functional results and fewer complications than dynamic hip screws (DHS? (2 Which kind of extracapsular femoral fractures would benefit from PFLCP fixation? PATIENTS AND METHODS: A total of 60 patients with intertrochanteric femoral fractures were recruited. Thirty patients underwent PFLCP fixation, and thirty patients underwent DHS fixation. Patient information, type of fracture, functional level (as assessed by Harris hip score, bone union, and implant complications were compared for the two treatment groups. RESULTS: The Mean duration for union in PFLCP group was 17 Weeks (12-24 weeks. The Mean duration for union in DHS group was 16 Weeks (12-28 weeks. Although there were better functional results (Harris Hip Score in PFLCP group when compared to DHS group the difference was not statistically significant (P value= 0.06 in our study. The complications like fracture of the lateral cortex, shortening >2cm, rotational deformity, varus mal-union screw cut off phenomenon, plate lift off were more in DHS group when compared to PFLCP. CONCLUSION: We conclude that there was no major difference between DHS and PFLCP for stable intertrochanteric fractures and PFLCP is a better alternative in fixing osteoporotic and unstable intertrochanteric fractures. Further large case control studies are needed in this regard.

  10. Aspectos sociodemograficos e clinicos da qualidade de vida relacionada a saude bucal em adolescentes

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    Karen Glazer Peres

    2013-12-01

    Full Text Available OBJETIVO: Estimar a prevalência e identificar fatores sociodemográficos e parâmetros bucais associados ao impacto negativo da condição bucal na qualidade de vida de adolescentes. MÉTODOS: Foram analisados dados de 5.445 adolescentes entre 15 e 19 anos que participaram do inquérito nacional de saúde bucal (SBBrasil 2010, considerando a complexidade do desenho amostral. O desfecho foi a qualidade de vida relacionada à saúde bucal, avaliada por meio do questionário Oral Impacts on Daily Performance e analisada de forma discreta. As variáveis de exposição foram sexo, cor da pele, escolaridade, renda familiar, idade, cárie não tratada, perda dentária, dor de dente, oclusopatias, sangramento gengival, cálculo dentário e bolsa periodontal. Foram conduzidas análises de regressão de Poisson e apresentadas as razões de médias (RM, com respectivos intervalos de 95% de confiança (IC95%. RESULTADOS: Dos pesquisados, 39,4% relataram pelo menos um impacto negativo na qualidade de vida. Após o ajuste, a média do impacto negativo foi de 1,52 (IC95%1,16;2,00 vez maior no sexo feminino e 1,42 (IC95% 1,01;1,99, 2,66 (IC95% 1,40;5,07 e 3,32 (IC95% 1,68;6,56 vezes maior nos pardos, amarelos e indígenas, respectivamente, em relação aos brancos. Quanto menor a escolaridade, maior a média de impacto negativo (RM 2,11, IC95% 1,30;3,41, assim como em indivíduos com renda familiar até R$ 500,00 (RM 1,84, IC95% 1,06;3,17 comparados aos de maior renda. Encontrou-se maior impacto na qualidade de vida entre adolescentes com quatro ou mais lesões de cáries não tratadas (RM 1,53, IC95% 1,12;2,10, uma ou mais perdas dentárias (RM 1,44, IC95%1,16;1,80, com dor de dente (RM 3,62, IC95% 2,93;4,46 e com oclusopatia grave (RM 1,52, IC95% 1,04;2,23 e muito grave (RM 1,32, IC95% 1,01;1,72. CONCLUSÕES: Os adolescentes brasileiros relataram alto impacto negativo da saúde bucal na sua qualidade de vida. A iniquidade em sua distribuição deve ser considerada ao planejar medidas de prevenção, monitoramento e tratamento dos agravos bucais nos grupos com maior impacto na qualidade de vida.

  11. Clinico-Epidemiological Study Of Factors Associated With Pregnancy Induced Hypertension

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    Amir Ali

    1998-01-01

    Full Text Available Research Question: What are the factors responsible for pregnancy induced hypertension. Objectives: To determine whether maternal, demographic, clinical and socio-economic characteristics are predictive of hypertension associated with pregnancy. Study design: Cross â€" Sectional. Participants: 728 hypertensive pregnant mothers attending the ante-natal clinic and admitted to the inpatient department of obstetric unit. Study Variables: Maternal, demographic and socio-economic characteristics. Outcome variable: Hypertension associated with pregnancy. Statistical analysis: Percentages and proportions. Results: The relative incidence of pregnancy induced hypertension was 71.29%. The critical evaluation of social and demographic characteristics of 519 cases of pregnancy induced hypertension revealed that nulliparous, young women (15-25 years belonging to low socio-economic group with lower literacy status and higher house hold work load are more vulnerable to develop pregnancy induced hypertension. Inadequate diet having low protein, rich carbohydrate and extra salt intake played a crucial role in the development of pregnancy induced hypertension. Conclusions: i since the nulliparous and younger women are vulnerable to develop pregnancy induced hypertension, the age at first pregnancy be reasonably delayed. ii Balanced diet is to be ensured through appropriate nutrition education and within t he resources of the family. iii The heavy household work is to be avoided and adequate rest and sleep be ensured in those who are at risk of developing pregnancy induced hypertension.

  12. A retrospective study of clinico-pathological spectrum of carcinoma breast in a West Delhi, India

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    Jitendra Singh Nigam

    2014-01-01

    Full Text Available Background: Data on the demographic profile of breast cancer patients from Delhi is scarce and whatever is available is from higher referral center. Our hospital caters to patients from an urban population of the lower socioeconomic strata and is a representation of cases at a tertiary care hospital in west Delhi. In Delhi, breast cancer (26.8% is commonest cancer among the female followed by cervix (12.5%, gallbladder (7.2%, ovary (7.1%, and uterus (3.3%. Aims and Objectives: A retrospective audit of breast cancer patients presenting at a tertiary referral center from 2004 to 2011. Materials and Methods: A total of 328 cases diagnosed as carcinoma breast on histopathology from year 2004 to 2011 were retrieved and studied retrospectively with regards to demographic profile and their histological features with estrogen receptor (ER, progesterone receptor (PR, and Her2neu status. Results: The median age of presentation was 49 years of age. Infiltrating ductal carcinoma (IDC, not otherwise specified (NOS was the commonest histopathological variant (81.40% followed by medullary carcinoma (10.36% and mucinous carcinoma (2.74%. Triple negative were found to be the commonest group comprising 39.4% of all the cases followed by ER and PR both positive. Pathological tumor, node, and metastasis (TNM staging showed most common group was T 2 N 0 M 0 ( 19.5% followed by T 2 N 1 M 0 (17.1% and T 2 N 2 M 0 (14%. Conclusion: The incidence of breast cancer in the India and include a higher incidence of ER, PR, and Her2neu negative disease in west Delhi.

  13. Correlation between clinico-pathological outcome and typing of Haemophilus parasuis field strains.

    Science.gov (United States)

    Aragon, Virginia; Cerdà-Cuéllar, Marta; Fraile, Lorenzo; Mombarg, Mark; Nofrarías, Miquel; Olvera, Alexandre; Sibila, Marina; Solanes, David; Segalés, Joaquim

    2010-05-19

    Haemophilus parasuis is the etiologic agent of Glässer's disease in pigs, which is pathologically characterized by serofibrinous polyserositis and arthritis. H. parasuis include virulent and non-virulent strains and confirmation of virulence in H. parasuis is still dependent on experimental reproduction of the disease. Since the variability in virulence is supported by serotyping and genotyping (particularly, multilocus sequence typing [MLST]), we examined the relationship between the classification of 8 field strains by these methods and their capacity to cause disease in snatch-farrowed, colostrum-deprived piglets. The severity of clinical signs and lesions produced by the different strains correlated with the quantity of H. parasuis recovered from the lesions. However, the virulence of the strains in the animal model did not show a total correlation with their serovar or their classification by MLST. More studies are needed to identify a virulence marker that could substitute animal experimentation in H. parasuis. In addition, we reproduced disease in domestic pigs with a strain isolated from the nasal cavity of wild boars. This result indicates the existence of virulent strains of H. parasuis in wild suids, which could produce disease under appropriate circumstances, and suggests a possible source of infection for domestic pigs. Copyright 2009 Elsevier B.V. All rights reserved.

  14. [Clinico-hemodynamic effects of psychotropic preparations and psychosomatic correlations in cardiac rhythm disorders].

    Science.gov (United States)

    Petrova, T R; Skibitskiĭ, V V

    1986-01-01

    A total of 136 patients with paroxysmal supraventricular tachyarrhythmia and tachyform of atrial fibrillation and polytopic extrasystoles were examined. The combination of cardiovascular and psychovegetative disturbances closely related to the expression of psychopathological shifts was revealed. The antiarrhythmic activity of psychotropic drugs (phenibut, sulpiride, pipofezin, tofizopam and falilepsin) depending on the nature of the time course of the emotional-personality status in prolonged intermittent treatment of patients with arrhythmias of the functional and mixed genesis was shown. A negative inotropic effect of phenibut, a hyperdynamic effect of sulpiride, pipofezin, falilepsin and a modulating effect of tofizopam were revealed. Prolonged therapy with psychopharmacological drugs in short courses was proposed.

  15. Clinico-pathological signiifcance of extra-nodal spread in special types of breast cancer

    Institute of Scientific and Technical Information of China (English)

    Ecmel Isik Kaygusuz; Handan Cetiner; Hulya Yavuz

    2014-01-01

    Objective: To investigate the signiifcance of extra-nodal spread in special histological sub-types of breast cancer and the relationship of such spread with prognostic parameters. Methods: A total of 303 breast cancer cases were classiifed according to tumor type, and each tumor group was subdivided according to age, tumor diameter, lymph node metastasis, extra-nodal spread, vein invasion in the adjacent soft tissue, distant metastasis, and immunohistochemical characteristics [estrogen receptor (ER), progesterone receptor (PR) existence, p53, c-erbB-2, and proliferative rate (Ki-67)]. hTe 122 cases with extra-nodal spread were clinically followed up. Results: An extra-nodal spread was observed in 40% (122 cases) of the 303 breast cancer cases. hTe spread most frequently presented in micro papillary carcinoma histological sub-type (40 cases, 75%), but least frequently presents in mucinous carcinoma (2 cases, 8%). Patients with extra-nodal spread had a high average number of metastatic lymph nodes (8.3) and a high distant metastasis rate (38 cases, 31%) compared with patients without extra-nodal spread. Conclusion: hTe existence of extra-nodal spread in the examined breast cancer sub-types has predictive value in forecasting the number of metastatic lymph nodes and the disease prognosis.

  16. Clinico-pathological features of breast myxoma: report of a case with histogenetic considerations.

    Science.gov (United States)

    Magro, Gaetano; Cavanaugh, Barbara; Palazzo, Juan

    2010-05-01

    We herein report the clinical, radiological, and pathological findings of a rare case of myxoma occurring in the breast parenchyma of a 75-year-old female. The tumor was incidentally detected at a mammographic screening and, ultrasonographically, presented as an ovoid mass. Histologically, an encapsulated hypocellular, myxoid tumor with low vascularization was evident. Neoplastic cells were round- to spindle/stellate-shaped and stained with vimentin and focally with calponin. We emphasize that morphology remains preeminent in the diagnosis of a breast myxoma, while immunohistochemistry may assist in ruling out other tumor entities. Differential diagnosis with all benign and malignant myxoid lesions, primarily occurring in the breast, is provided. The histogenesis of breast myxoma is unknown. The lack of expression of desmin, alpha-smooth muscle actin, CD34, CD99, CD10, bcl-2 protein, and estrogen/progesterone/androgen receptors, all markers characteristically expressed by "the benign spindle cell tumors of the mammary stroma," would suggest that breast myxoma does not fall into this tumor category and that its putative precursor mesenchymal cell resides in the interlobular stroma.

  17. Clinico-pathogenetic findings and management of chondrodystrophic myotonia (Schwartz-Jampel syndrome: a case report

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    Francomano Clair A

    2003-07-01

    Full Text Available Abstract Background Chondrodystrophic myotonia or Schwartz-Jampel syndrome is a rare genetic disorder characterized by myotonia and skeletal dysplasia. It may be progressive in nature. Recently, the gene responsible for Schwartz-Jampel syndrome has been found and the defective protein it encodes leads to abnormal cartilage development and anomalous neuromuscular activity. Case Presentation We report the clinical findings and the management of an 8-year-old boy with this disorder. The molecular findings confirm that the patient is a compound heterozygote with a different splicing mutation in each Perlecan allele. This resulted in a significant reduction in the production of the encoded normal protein. Conclusion We discuss the multi-disciplinary management of Schwartz-Jampel syndrome that will facilitate optimal care and timely intervention of patients with this disorder.

  18. Clinico-radiological improvement in an immunocompetent patient presented with scedosporium apiospermum osteomyelitis.

    Science.gov (United States)

    Mohan, Rahul; Gopakumar, T S

    2016-01-01

    Scedosporium apiospermum is frequently found as a saprophyte in soil, sewage and contaminated water. Its manifestations in immunocompetent patients are usually localised and in immunodeficient patients, it causes invasive systemic diseases. We are reporting the case of a 40-year-old male, who presented with pain, oedema and multiple discharging sinuses over the lateral aspect of the left foot with history of thorn prick. On examination, there were multiple active sinuses with tenderness and local rise in temperature. Calcaneum on palpation showed a thickened and irregular surface with limitation of ankle and subtalar movements. Blood investigations showed a moderate rise in ESR and CRP. X-rays showed typical features of chronic osteomyelitis with sclerosis, cavities and irregular bone contour. CT report showed features of osteomyelitis involving calcaneum, talus, cuneiforms and navicular bone with periarticular soft tissue involvement and mild focal collection in the calcaneum. On repeated culture, it was found to be scedosporium apiospermum fungus. We managed the case with voriconazole therapy and it responded with excellent clinical and radiological improvement by 9 months.

  19. Clinico-immunological aspects of vernal catarrh in hilly terrains of Himachal Pradesh

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    R Bisht

    1992-01-01

    Full Text Available Very few immunological studies in vernal catarrh have been conducted in India and abroad, but none in Himachal Pradesh in spite of its high incidence in the State. In the present study 25 patients of vernal catarrh residing at a height ranging between 1000 to 2500 meters above mean sea level have been evaluated. Their immunological status of serum and tears after detailed clinical assessment was studied by single radial immunodiffusion technique of Mancini et al. The values of serum IgA and IgM were significantly higher in patients than in controls. The serum IgE level had no significant difference. The IgG was significantly lower in patients with vernal catarrh. The values of tear IgM, IgE and IgA in these patients were significantly higher than in controls. However, in no case or control group C3C and C4 were detected in tears. The limbal type of vernal catarrh was found to be the most common in this part of the country. No mixed case was seen. Derangement of the immune system in the pathogenesis of vernal catarrh is suggested.

  20. Excellent Functionality Despite Clinico-Radiological Deformity in Osteomyelitis Variolosa - A Case Report.

    Science.gov (United States)

    Mugalur, Aakash; Shahane, Sunil M; Samant, Ashwin; Pathak, Aditya C; Reddy, Rajeev

    2015-01-01

    Despite the eradication of smallpox from the world in 1980 the osteo-articular sequelae of smallpox are still occasionally noticed in previously endemic areas. The sequelae of osteomyelitis variolosa may raise a diagnostic challenge to the untrained eyes of the surgeon. We present a case of "osteomyelitis variolosa" in a 70 years old patient. The patient had bilateral dislocation of the elbow joint with multidirectional instability. There was distortion of the articular surfaces and ankylosis of the bilateral proximal radio-ulnar joint. Hypoplasia of the right ulna with short fourth and fifth metacarpals of the left hand and hypoplasia of right fourth metacarpal with cortical thickening was noted radiologically. The patient had minimal disability of his elbows despite the striking radiological abnormality and was functionally independent.

  1. An Analysis of Clinico-Radiological and Histopathological Correlation in Tuberculosis of Spine

    Directory of Open Access Journals (Sweden)

    Sadik I Shaikh

    2013-06-01

    Full Text Available Background: In the recent past, the use of computerized axial tomography and magnetic resonance imaging has helped to differentiate spinal tuberculosis from radiologically similar lesions. Objective: The objectives of the study was to assess how dependable clinical and radiological features are in estab-lishing a diagnosis of spinal tuberculosis; and to identify other conditions which may have clinical and radiological features similar to those seen in patients with spinal tuberculosis. Methodology: Two hundred and sixty-seven consecutive patients with clinical and radiological features suggestive of tuberculosis of the spine treated over a period of five years were analysed. This retrospective case series analysis was done in a tertiary care hospital. The clinical presentation, radiological features and the erythrocyte sedimentation rate were correlated with the histopathological diagnosis on tissue obtained by open biopsy in 130 cases during surgery and in 137 cases by closed vertebral biopsy. Results: One hundred sixty-six cases were histologically proved as tuberculosis and 74 proved to be non-tuberculous lesions. Twenty-seven cases in which the biopsy was inconclusive were excluded from the study. The study demonstrated that tuberculous lesions were commoner in younger patients and the lesion was more often in the paradiscal region as compared to non-tuberculous lesions. However, all other clinical and radiological variables were not significantly different to enable reliable identification of tuberculous lesions on the basis of clinical and radiological features alone. Conclusion: It is recommended that all vertebral lesions suspected to be of tuberculous origin not responding to empirical antituberculosis therapy should have a definitive histopathological diagnosis and radiological investigation to facilitate appropriate treatment. [Natl J Med Res 2013; 3(3.000: 198-202

  2. Pulmonary Alveolar Microlithiasis - Clinico-Radiological dissociation - A case report with Radiological review.

    Science.gov (United States)

    Khaladkar, Sanjay Mhalasakant; Kondapavuluri, Sushen Kumar; Kamal, Anubhav; Kalra, Raghav; Kuber, Rajesh

    2016-01-01

    Pulmonary alveolar microlithiasis (PAM) is a rare chronic lung disease characterized by deposition of intra alveolar calcium and phosphate in bilateral lung parenchyma with predominance in lower and mid zones. Etiology and pathogenesis is not fully understood. However, mutation in SLC34A2 gene that encodes a sodium phosphate co-transporter in alveolar type-II cells resulting in formation and accumulation of microliths rich in calcium phosphate due to impaired clearance is considered the cause of disease. Patients with PAM are asymptomatic till development of hypoxemia and cor pulmonale. It remains static, while in some it progresses to pulmonary fibrosis, respiratory failure and cor pulmonale. We report a case of 44 year old male patient presenting with progressive shortness of breath on exertion for one year in duration with dry cough, more since last six months. Chest radiograph showed dense micronodular opacities giving classical sandstorm appearance. High resolution computed tomography (HRCT) showed microcalcification, subpleural cystic changes and calcified pleura. Lung biopsy showed calcospherites within alveolar spaces.

  3. Peripheral desmoplastic ameloblastoma in adolescent age: clinico-pathological and immunohistochemical analisys of a case.

    Science.gov (United States)

    Oteri, Giacomo; Lentini, Maria; Pisano, Michele; Cicciù, Marco

    2014-01-01

    The Extraosseous or Peripheral Ameloblastoma (PA) is a rare and benign odontogenic tumour, representing 1% to 5% of all ameloblastomas. It is usually localized in the soft oral tissues, without deep bone involvement. Its biological behaviour is specific, and several authors define PA as a non-infiltrating hamartomatous lesion. Indeed, recurrences rarely occur and progression in malignant tumors appears to be rare. The PA originates from the tooth-forming apparatus and it consists of proliferating odontogenic epithelium, exhibiting the same histological cell types and patterns of the intraosseous counterpart or infiltrating ameloblastoma. The peripheral desmoplastic ameloblastoma (PDA) can be classified as a newly recognized and very rare histological variant. To our knowledge, only a few cases of adult patients affected by PDA have been published. The aim of this paper is to report a case of PDA affecting an adolescent patient. The clinical-pathological and immunohistological features are discussed in order to improve knowledge regarding a correct diagnosis and to differentiate PDA lesions from similar diseases.

  4. Septal panniculitis: Clinico-pathological review of the literature and case presentation

    Directory of Open Access Journals (Sweden)

    Gabriela Martinez Braga

    2014-01-01

    Full Text Available The panniculitides comprise a large and heterogeneous group of diseases, with a high prevalence in the general population, in which the inflammatory process affects the subcutaneous tissue. We briefly review the classification, clinical and histology of the primary panniculitides and present a representative case.

  5. Plasmacytoid Transitional Cell Carcinoma of Bladder: A Clinico-pathological Study and Review of Literatures

    Institute of Scientific and Technical Information of China (English)

    FENG Xiaoli; ZHANG Hongtu; SUN Yuntian; LIU Xiuyun

    2006-01-01

    Objective: To study the pathologic features of plasmacytoid transitional cell carcinoma of the bladder, and to analyze the diagnostic features, criteria for differential diagnosis and the clinical significance of the tumor. Methods: Two cases of bladder plasmacytoid transitional cell carcinoma were studied. Routine paraffin sections with HE staining, Pap smear and immunohistochemistry by S-P method were observed under a light microscope. Pathological and clinical data were analyzed by comparison with early reported cases in literatures. Results: A characteristic feature of this tumor was of deep invasion in the lamina propria and/or muscularis propria, in addition to the component of carcinoma in situ in the mucosa, when tumors were diagnosed. The histological pattern and cytological features showed similarity to a plasmacytoid tumor. The tumor cells were strongly positive for AE1/AE3, CEA and CK18. The prognosis appeared to be worse than ordinary transitional cell carcinoma. Conclusion: The plasmacytoid transitional cell carcinoma of bladder is rare but has typical pathological, immunohistological and clinical features. Pathologists should be aware of this kind of primary tumor of bladder.

  6. The clinico-anatomic explanation for tibial intraneural ganglion cysts arising from the superior tibiofibular joint

    Energy Technology Data Exchange (ETDEWEB)

    Spinner, Robert J. [Mayo Clinic, Department of Neurologic Surgery, Rochester, Minnesota (United States); Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota (United States); Mayo Clinic, Department of Anatomy, Rochester, Minnesota (United States); Mokhtarzadeh, Ali; Schiefer, Terry K. [Mayo Clinic College of Medicine, Rochester, Minnesota (United States); Krishnan, Kartik G. [Carl Gustav Carus University Hospital, Department of Neurological Surgery, Dresden (Germany); Kliot, Michel [University of Washington, Department of Neurosurgery, Seattle, Washington (United States); Amrami, Kimberly K. [Mayo Clinic, Department of Radiology, Rochester, Minnesota (United States)

    2007-04-15

    To demonstrate that tibial intraneural ganglia in the popliteal fossa are derived from the posterior portion of the superior tibiofibular joint, in a mechanism similar to that of peroneal intraneural ganglia, which have recently been shown to arise from the anterior portion of the same joint. Retrospective clinical study and prospective anatomic study. The clinical records and MRI findings of three patients with tibial intraneural ganglion cysts were analyzed and compared with those of one patient with a tibial extraneural ganglion cyst and one volunteer. Seven cadaveric limbs were dissected to define the articular anatomy of the posterior aspect of the superior tibiofibular joint. The condition of the three patients with intraneural ganglia recurred because their joint connections were not identified initially. In two patients there was no cyst recurrence when the joint connection was treated at revision surgery; the third patient did not wish to undergo additional surgery. The one patient with an extraneural ganglion had the joint connection identified at initial assessment and had successful surgery addressing the cyst and the joint connection. Retrospective evaluation of the tibial intraneural ganglion cysts revealed stereotypic features, which allowed their accurate diagnosis and distinction from extraneural cases. The intraneural cysts had tubular (rather than globular) appearances. They derived from the postero-inferior portion of the superior tibiofibular joint and followed the expected course of the articular branch on the posterior surface of the popliteus muscle. The cysts then extended intra-epineurially into the parent tibial nerves, where they contained displaced nerve fascicles. The extraneural cyst extrinsically compressed the tibial nerve but did not directly involve it. All cadaveric specimens demonstrated a small single articular branch, which derived from the tibial nerve to the popliteus. The branch coursed obliquely across the posterior surface of the popliteus muscle before innervating the postero-inferior aspect of the superior tibiofibular joint. The clinical, MRI and anatomic features of tibial intraneural ganglion cysts are the posterior counterpart of the peroneal intraneural ganglion cysts arising from the anterior portion of the superior tibiofibular joint. These predictable features can be exploited and have implications for the pathogenesis of these intraneural cysts and treatment outcomes. These ganglion cysts are joint-related and provide further evidence to support the unifying articular theory. In each case the joint connection needs to be identified preoperatively, and the articular branches and the superior tibiofibular joint should be addressed operatively to prevent cyst recurrence. (orig.)

  7. Clinico-Pathological Profile and Surgical Outcome of Patients of Gastrointestinal Tuberculosis Undergoing Laparotomy.

    Science.gov (United States)

    Pathak, Priyank; Sahu, Shantanu Kumar; Agrawal, Saurabh

    2016-01-01

    Tuberculosis is one of the earliest diseases affecting the mankind. Abdominal tuberculosis constitutes a common public health issue in developing countries like ours. Gastrointestinal tuberculosis often involves the ileocecal region. Surgery in case of abdominal tuberculosis is required to overcome the deleterious effects of the disease like tissue disorganization, obstruction and perforatio.

  8. Pattern Analysis and Decision Support for Cancer through Clinico-Genomic Profiles

    Science.gov (United States)

    Exarchos, Themis P.; Giannakeas, Nikolaos; Goletsis, Yorgos; Papaloukas, Costas; Fotiadis, Dimitrios I.

    Advances in genome technology are playing a growing role in medicine and healthcare. With the development of new technologies and opportunities for large-scale analysis of the genome, genomic data have a clear impact on medicine. Cancer prognostics and therapeutics are among the first major test cases for genomic medicine, given that all types of cancer are related with genomic instability. In this paper we present a novel system for pattern analysis and decision support in cancer. The system integrates clinical data from electronic health records and genomic data. Pattern analysis and data mining methods are applied to these integrated data and the discovered knowledge is used for cancer decision support. Through this integration, conclusions can be drawn for early diagnosis, staging and cancer treatment.

  9. A CLINICO-HISTOPATHOLOGICAL STUDY OF ACQUIRED PALMOPLANTAR KERATODERMA IN A RURAL-BASED TERTIARY HOSPITA

    Directory of Open Access Journals (Sweden)

    Sandeep

    2014-07-01

    Full Text Available BACKGROUND: Palmoplantar keratodermas are a diverse group of dermatological disorders characterized by abnormal thickening of skin over palms and soles. It is classified into inherited and acquired disorders. A number of diseases have been implicated as the cause of this common and interesting group and not many studies have been done in the acquired subset of this disorder. We have undertaken this study for finding out the incidence of various etiological factors in a rural based tertiary hospital. OBJECTIVE: To evaluate the epidemiological, clinical, and histopathological confirmation of acquired palmoplantar keratodermas (PPKD. MATERIALS AND METHODS: The study population consists of 100 consecutive patients aged 10 years and above, with acquired palmoplantar keratodermas seen in Dermatology Outpatient Department in a rural based tertiary hospital. RESULTS: Age of the patients ranged from 11 to 75 years and the common age group was 41 – 50 years. Male predominance (1.17:1 was seen in our study and farmers, manual laborers and house-wives were most commonly affected. The dermatoses causing PPKD in our study were palmoplantar psoriasis, eczema, lichen planus and warts. A rare case of acquired palmoplantar keratoderma secondary to lichenoid drug eruption was observed by us which was not reported in literature to best of our knowledge. Many cases could not be diagnosed by histopathology; systemic examination and other investigations were normal hence were classified under idiopathic PPKD. CONCLUSION: Psoriasis, eczemas, lichen planus and warts were the dermatoses causing PPKD in our study. A rare case of lichenoid drug eruption causing PPKD is being reported by us, which was not reported in literature to the best of our knowledge.

  10. The clinico-radiological spectrum of masseteric venous malformation: Case report.

    Science.gov (United States)

    Agarwal, Kavita; Umarji, Hemant R; Kadam, Sonali; Agrawal, Neeraj

    2016-11-01

    Due to its location, intra-masseteric venous malformation often mistaken for a parotid swelling and clinical examination alone frequently underestimates the deep extension of the lesion and rarely gives accurate pre-operative diagnosis. But once it is diagnosed, the feasibility of the treatment and the plan of approach depend on accurate delineation of the extent, size and location of the lesion. Therefore, complimentary radiographic studies are essential for its management. In this case report, typical features of venous malformation within the masseter muscle, including clinical findings (turkey wattle sign) and imaging are presented. Ultrasonography and CT scan were non-contributory in the diagnosis, while on MRI, masseteric venous malformations have a typical appearance that allowed early identification, patient education and its management.

  11. Dermatofibrosarcoma Protuberans: A comprehensive review on the spectrum of clinico-radiological presentations.

    Science.gov (United States)

    Sung, Tony Ht; Tam, Annie Cw; Khoo, Jennifer Ls

    2017-02-01

    Dermatofibrosarcoma Protuberans (DFSP) is a rare malignant soft-tissue neoplasm which is often misdiagnosed due to its indolent clinical course and non-specific radiological appearances. An observation case series was conducted with retrospective review of clinical and radiological data of DFSP patients presenting to a major tertiary hospital in Hong Kong for radiological assessment between November 2006 and February 2016. Seven patients with confirmed histological diagnosis of DFSP were included. Tumour sizes at presentation ranged from 1 to 5 cm, most commonly (n = 6) occurred over chest wall and abdominal wall. History of previous local trauma or surgery was identified in the majority of cases (n = 4). There was poor correlation between pre-imaging clinical diagnoses and pathological diagnoses. Local recurrence and tumour de-differentiation with sarcomatous changes occurred in the minority of cases (n = 2). A common radiological 'claw' sign at the lesion/skin interface formed by elongated appendages of the tumour superficially was appreciated in most cases (n = 6). A history of previous local trauma or surgery serves as a possible etiological factor for the development of DFSP. High clinical suspicion for the entity is essential in its detection and differentiation from simple wound complications and local recurrence of other benign lesions. The radiological 'claw' sign at the lesion/skin interface might serve as a tell-tale sign for cutaneous tumour involvement. A comprehensive analysis of imaging findings in conjunction with individual clinical presentations is the key to accurate diagnoses and proper management.

  12. Fetal MR Imaging Analysis of Sirenomelia with Clinico Radiographic Correlation: A Case Report.

    Science.gov (United States)

    Nori, Madhavi; Prasad, Raghavendra G; Reddy, Arvind K; Cheguri, Sandeep Reddy

    2016-06-01

    Sirenomelia is a social curiosity, a medical and diagnostic challenge prenatally compounded by varied diagnostic difficulties. Prenatal diagnosis of sirenomelia was and continues to be a challenge although von klippel et al., described a case at 10 weeks of gestational age. However, they needed a second imaging at 12(th) week for confirmation. First trimester or early second trimester anatomic survey on ultrasound and MRI is accurate for the diagnosis thereby avoiding unnecessary complex pregnancy. We report a case of second trimester diagnosed sirenomelia, with detailed analysis of image findings on ultrasound and fetal MRI.

  13. Serologic evidence of human leptospirosis in and around Kolkata, India:A clinico-epidemiological study

    Institute of Scientific and Technical Information of China (English)

    Manisha DebMandal; Shyamapada Mandal; Nishith Kumar Pal

    2011-01-01

    Objective:To investigate the prevalence of leptospirosis among patients from within and outside Kolkata, India, attending the Calcutta School of Tropical Medicine, for treatment during August 2002 to August2008.Methods: The leptospirosis cases were determined on the basis of clinical, epidemiological, and biochemical factors, and were tested for leptospiral antibodies using IgM ELISA. Serum samples with absorbance ratio ≥1.21were interpreted as reactive.Results: The commonest presentation involved fever, headache and jaundice. The male-female ratio was 61:46. A total of65(64.20%) cases had abnormal liver and renal functions respectively, and57.1% had both the abnormalities. The highest incidence(75, 35.04%) was recorded in September-October followed by July-August(53, 24.77%). The reactive cases had absorbance ratios between 1.21 and8.21, and53 showed equivocal result, while IgM non reactivity were seen in 90 patients (absorbance ratios 0.10-0.90). The patients responded to treatment with parenteral antibiotics, penicillin, ceftriaxone and cefotaxime; follow up did not reveal case fatality.Conclusions:The cardinal signs of leptospirosis help in making clinical diagnosis, but in any hyper-endemic situation any patient reporting with acute fever and signs of pulmonary, hepatic or renal involvement should be suspected to have leptospirosis and investigated accordingly. Increased awareness, and early diagnosis and treatment, can reduce mortality due to leptospirosis.

  14. Clinico-hematological and tissue changes induced by butachlor in male Japanese quail (Coturnix japonica).

    Science.gov (United States)

    Hussain, Riaz; Khan, Ahrar; Mahmood, Fazal; Rehan, Sarmad; Ali, Farah

    2014-02-01

    The present experiment was executed to determine the pathological effects induced by concurrent feeding of butachlor (chloroacetanilide herbicide) in male Japanese quail. For this purpose mature male quail about 4-5weeks of age were procured from the local market and randomly divided into six equal groups (A-F). Butachlor was mixed in corn oil and administered orally for 30days using crop tube. Four birds from each group were killed at day 10, 20 and 30 of the experiment and blood was collected with and without anticoagulant. The birds in groups (A-D) did not reveal any clinical and behavioral alterations. Clinical signs like watery droppings, dullness, ruffled feather, depression, decrease frequency of crowing, mounting with pen mates and foam production were observed. Maximum intensity of these clinical signs and behavioral alterations were observed in group F throughout the experiment. Significant lower values of erythrocytes, hematocrit percent and hemoglobin were recorded. Significantly increased numbers of erythrocytes with micronuclei, lobed and notched nuclei were observed. Histopathologically, enlarged intertubular space, fewer numbers of round spermatids, necrotic spermatids and admixture of dead spermatids were observed in testes. The results revealed significant increase in serum lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and urea concentrations. The results of present experimental study indicated that butachlor induces hematobiochemical and testicular changes in birds.

  15. Clinico-pathological study of glomerular diseases in patients with significant proteinuria in North India

    Directory of Open Access Journals (Sweden)

    Irneet Mundi

    2014-01-01

    Full Text Available Proteinuria is a common manifestation of renal disease. The present study was carried out to analyze the clinic-pathological correlation, assess the value of histopathology and immunofluorescence (IF as well as note the spectrum of renal diseases in patients with significant proteinuria. Fifty consecutive patients having proteinuria >1 g/24 h underwent ultrasound-guided percutaneous renal biopsy. Clinical information was correlated with the pathological findings and the results were analyzed. The patients were in the age range of 12-79 years. Males (60% outnumbered females (40% in all the disease categories except lupus nephritis and IgA nephropathy. The most common clinical presentation was the nephrotic syndrome, seen in 31 cases (62%. Primary glomerular diseases (72% were more common than secondary glomerular diseases (24% and tubulointerstitial diseases (4%. Overall, the most common pathological diag-nosis was focal and segmental glomerulosclerosis (FSGS (20%, followed by membranous glomerulonephritis (MGN (18%. In young patients (age 60 years it was FSGS (60%. IF modified the diagnosis in 12% of the cases. The concordance between clinical diagnosis and pathological diagnosis was 66%. The difference between clinical diagnosis and final diagnosis was statistically significant. Our study further reinforces the knowledge that renal biopsy helps in accurate diagnosis and, thus, helps in appropriate management of the patients. IF provides additional information that can make the morphologic diagnosis considerably more precise.

  16. Clinico-therapeutic management of Dimethoate-30% (Rogor poisoning in a non-descript bullock

    Directory of Open Access Journals (Sweden)

    S. N. Dhonde

    2008-12-01

    Full Text Available A non-descript bullock suffering from dimethoate-30%(Rogor poisoning was treated using Inj. Dexamethasone, Inj. 2-PAM, Inj. B-complex and Sodium Bicarbonate alongwith fluid therapy, the bullock responded well to the therapy and survived. [Veterinary World 2008; 1(6.000: 178-179

  17. Sensibilidad y resistencia en el antibiograma del Staphylococcus aureus en pacientes del Hospital Clinico Viedma

    OpenAIRE

    Gustavo Favio Lazo Arispe; Esedim Mamani Flores; Efraín Vargas Loroño; Jhunior Ramiro Camacho Aguilar; Dr. Oscar Sahonero Ampuero

    2013-01-01

    La resistencia bacteriana a los antibióticos es un problema de salud, ya que conlleva la utilización de fármacos más complejos y muy poco accesibles. El objetivo principal de este trabajo es conocer la sensibilidad y resistencia de Staphylococus aureus a los antibióticos, en pacientes que asistieron a Emergencias del Hospital Clínico Viedma. Mediante la realización de un estudio de tipo descriptivo-prospectivo-transversal; se tomó muestras por conveniencia no probabilística de ...

  18. Protese testicular de colageno na orquiectomia subcapsular : estudo clinico-experimental

    OpenAIRE

    Paulo Cesar Rodrigues Palma

    1988-01-01

    Resumo: Este trabalho foi realizado no Núcleo de Medicina e Cirurgia Experimental da Faculdade de ciências Médicas e no Hospital das Clínicas da Universidade Estadual de Campinas, com o intuito de introduzir uma nova prótese testicular na orquiectomia subcapsular, como tratamento paliativo do cancer prostatico avançado. A prótese biológica desenvolvida pelo Prof. Dr. Benedicto de Campos Vidal do Departamento de Biologia Celular da universidade Estadual de Campinas foi elaborada com colágeno l...

  19. Clinico-radiological profile and risk factors in patients with anthracosis

    Directory of Open Access Journals (Sweden)

    Virendra Singh

    2015-01-01

    Full Text Available Background: Anthracosis is the black pigmentation of the mucosal lining of the tracheo-bronchial tree. The significance of this finding is not known and often ignored. The aim of the present study is to find the association of anthracosis with demographic variables, biomass fuel and occupational exposure, respiratory diseases, radiological pattern and functional morbidity. Materials and Methods: Enrolment of the subjects for the study was done at SMS hospital, Jaipur. Patients with anthracosis evident on bronchoscopy were included as the cases. Patients without anthracosis on bronchoscopy, matched according to age, gender and smoking habits, were included in the control group. Subjects in both the arms completed a questionnaire and also underwent computed tomography (CT of the chest and six minute walk test (6MWT. Results: Thirty cases and 53 controls were included in the study. The patients with anthracosis presented with symptoms ranging from cough (76.65%, hemoptysis (46.6%, fever (26.6%, dyspnea (90% and malaise (73.3%. Biomass fuel exposure for the cases was 35.13 ± 55.86 hours in a year and for the controls was 28.15 ± 40.09 hours in a year (P > 0.05. Stone mining was significantly associated with anthracosis (P < 0.05. CT chest revealed fibrosis (43.3%, consolidation (33.3%, cavitation (16.6% and mass (46.6% in the cases. Sixty percent of cases and 15% of controls were diagnosed to have either old or active pulmonary tuberculosis (P < 0.05. Conclusions: Anthracosis is associated with pulmonary tuberculosis. Biomass exposure is not significantly associated with anthracosis. Post tubercular fibrosis is more common on CT chest of patients with anthracosis.

  20. Eficacia de cremas dentales con fluoruros sobre lesiones de mancha blanca, ensayo clinico aleatorizado

    National Research Council Canada - National Science Library

    Gonzalez-Martinez, Farith; Lujan-Pardo, Maria Del Pilar; Carmona-Arango, Luis Eduardo

    2013-01-01

    Introduccion y objetivo: El uso de cremas dentales para prevencion de caries es considerada la estrategia preventiva de mayor eficacia, aunque es necesario implementar protocolos adecuados al riesgo individual, gravedad...

  1. Hartnup syndrome, progressive encephalopathy and allo-albuminaemia. A clinico-pathological case study.

    Science.gov (United States)

    Schmidtke, K; Endres, W; Roscher, A; Ibel, H; Herschkowitz, N; Bachmann, C; Plöchl, E; Hadorn, H B

    1992-12-01

    Clinical, biochemical, neuropathological and neurochemical findings in a case of Hartnup syndrome are reported. After initially normal development, the affected girl suffered progressive neuropsychiatric decline with statomotor and mental retardation and intractable seizures and died at the age of 2 years. Postmortem neuropathological and neurochemical investigations showed a combination of extensive neuronal degeneration and cerebral dysmyelination. Pathogenetic hypotheses and the relationship between neuropsychiatric disease and Hartnup syndrome are discussed. Additionally, a fast type bisalbuminaemia present in the girl and her mother is described.

  2. CLINICO-MORPHOLOGICAL RESEARCH OF BIO-OSS ® DURING BONE-PLASTIC OPERATIONS

    Directory of Open Access Journals (Sweden)

    Pavel SIDELNIKOV

    2016-03-01

    Full Text Available Aim: To study the clinical and morphological characteristics of Bio-Oss ® and Bio-Gate ® materials during bone-plastic operations, especially bone regeneration after surgical interventiond. Materials and method: The pathomorphological study was performed with the intravital biopsy material of bone tissue from augmentation areas, obtained during implants placement. Clinical studies included subjective and objective methods, in particular X-ray analysis and photo documenting. Bio-Oss ®, Bio-Gide ®, Bio-Gide ® Perio membranes, Resor-Pin pins, U-impl implant systems were investigated and 231 operations were performed with Bio-Oss ® and Bio-Gate ®, of which 38 cases of sinus lifting, 145 of bone plasty with simultaneous implantation and 48 cases of periodontal surgery. Results: Usage of bone-plastic Bio-OSS ® and Bio-Gate ® materials during various bone-plastic and periodontal operations assures a high clinical effect (from 93 to 99%. Morphologically, it has been observed that, after usage of bone Bio-OSS ® and Bio-Gate ® materials, a new osteoid tissue was formed, similar to the bone tissue of the alveolar process, with high mineralization levels, especially in the first 2 years, due to the simultaneous resorption of the material. The newly-formed tissue has a classical design and can fully perform the functions of jaw bones, especially for carrying loads transmitted with either teeth or implants.

  3. Electrophysiologic and clinico-pathologic characteristics of statin-induced muscle injury

    Directory of Open Access Journals (Sweden)

    Mohammed Abdulrazaq

    2015-08-01

    Conclusion: Atorvastatin increased average creatine kinase, suggesting, statins produce mild muscle injury even in asymptomatic subjects. Diabetic statin users were more prone to develop muscle injury than others. Muscle fiber conduction velocity evaluation is recommended as a simple and reliable test to diagnose statin-induced myopathy instead of invasive muscle biopsy.

  4. Effect of Diuretics on Salivary Flow, Composition and Oral Health Status: A Clinico-biochemical Study

    Science.gov (United States)

    Prasanthi, B; Kannan, N; Patil, RR

    2014-01-01

    Background: Saliva represents an increasingly useful tool of diagnosis. Several factors such as salivary flow rates (SFRs) (unstimulated and stimulated) (U and S), pH, buffering capacity and consistency can be altered due to several disease processes or medications prescribed for various diseases. Alterations of SFRs, pH, buffering capacity and various ion concentrations can influence the pathogenesis of some of the oral diseases. Aim: Evaluation of the effect of diuretics on oral health status with regard to SFRs (U and S), pH, buffering capacity, total protein content, various ion concentrations and oral mucosal lesions. Subjects and Methods: A total of 100 patients were categorized into test group and control group based on usage of diuretics. Unstimulated and stimulated saliva were collected and evaluated for flow rates. Salivary pH was measured using pH meter. Buffering capacity was measured using Aranha's technique. Salivary Na+, K+ and Cl− concentrations were measured using electrolyte analyzer CORNLEY ACCULYTE-3P in ion-selective electrode method. Salivary total protein content was measured by spectrophotometric method. Dental Caries and periodontal status were measured by using decayed, missing, filled teeth index and Russell's periodontal index respectively. Oral mucosal examination was carried out to identify the mucosal lesions. Results: The obtained results were subjected to statistical analysis using Statistical package for social sciences software (SPSS), version 16, IBM Company by Chi-square test and unpaired t-test. Highly significant P for alterations of SFR/U (P < 0.001), SFR/S (P < 0.001), pH (P < 0.001), Na+ concentration (P < 0.001), buffering capacity (P < 0.001) and moderate significance for Cl− concentration (P < 0.01) were found. Alterations of total protein (P = 0.14) and K+ (P = 0.65) concentrations were not statistically significant. High prevalence was found for caries (P < 0.01), periodontal status (P < 0.001) and mucosal lesions (P < 0.01). Conclusion: Our study shows that diuretic medication significantly reduces SFRs (xerostomia) and alters salivary composition which may have an impact on the incidence of dental caries, periodontal diseases and mucosal lesion formation. PMID:25221702

  5. CT findings in cerebral palsy - An attempt at clinico-radiological correlation

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Hyo Keun; Lee, Kil Woo; Choo, In Wook; Kim, Mee Kang; Bae, Sang Hoon [Hallym University College of Medicine, Seoul (Korea, Republic of); Lee, Mun Gyu [Ulsan University College of Medicine, Seoul (Korea, Republic of)

    1990-07-15

    CT scans of one hundred-three children with cerebral palsy were analyzed retrospectively and correlated with various clinical assessment. Incidence of pathologic CT scans was 71% and most common pathology was brain atrophy (45%). Other pathology consisted of brain anomaly (13%), infarction (11%), hydrocephalus (6%), porencephalic cyst (6%), diffuse periventricular low density (5%) and pathologic calcification (4%). No statistically significant correlation could be found between the types of cerebral palsy and incidence of pathologic CT findings. Higher incidence of pathologic CT scans could be shown in the group that physical handicap was severe and etiological factor was prenatal or postnatal and in the patients with seizure.

  6. Carga inmediata sobre implante unico: estudio clinico prospectivo.(ARTICULOS ORIGINALES DERIVADOS DE INVESTIGACION)

    National Research Council Canada - National Science Library

    Arango B., Paola Andrea; Arismendi E., Jorge Alberto; Porras, Andres Felipe

    2009-01-01

    Introduccion: la carga inmediata se ha convertido en una alternativa viable de tratamiento que ofrece multiples beneficios a los pacientes como funcion y estetica inmediata, reduccion del trauma quirurgico...

  7. Abnormal neuronal migration: radiologic-clinic study. Alteraciones en la migracion neural: estudio clinico-radiologico

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Fernandez, M.; Menor Serrano, F.; Bordon Ferre, F.; Garcia Tena, J.; Esteban Hernandez, E.; Sanguesa Nebot, C.; Marti Bonnati, L. (Hospital Infantil La Fe, Valencia (Spain))

    1994-01-01

    We present our experience in 18 pediatric patients with abnormal neuronal migration. Seven cases of heterotopia of the gray matter, 7 agyria-pachygyria complexes, 1 case of polymicrogyria, 2 cases of schizencephaly and 1 case of hemimegalencephaly were diagnosed by means of ultrasonography, computed tomography and magnetic resonance. The clinical picture was reviewed in each case, with special attention to the occurrence of convulsions, psycho motor development and visual changes. In general, the greater the morphological change, the greater the neurological involvement in these patients. However, the two cases of schizencephaly presented mild clinical expression. Magnetic resonance increases the diagnostic yield in neuronal migration disorders. Nevertheless, either ultrasonography or, especially, computed tomography is useful as a first diagnostic approach in these malformative disorders. (Author)

  8. [Clinical and clinico-histological markers in chronic destructive adult periodontitis].

    Science.gov (United States)

    Hernández Vallejo, G; García Rodríguez, M D; Tejerina Lobo, J M; López Sánchez, A F; De la Roca, C

    1989-05-01

    This study was designed to evaluate the significance and interrelationship of clinical parameters and their association with histologic changes in advanced destructive periodontitis. 158 patients with PDI greater than 4 (Ramfjord) were selected, evaluating the size, contouring, bleeding, consistency, colour and gingival pain. Epithelial ulceration of soft periodontal pockets were also evaluated. The results showed a statistically significant association between purplish colour and gingival fibrosis and advanced stage of the disease. Gingival bleeding on probing was the most important clinical parameter in advanced phases of the disease, either alone or in association with other parameters such as the presence of epithelial ulcerations. The Periodontal Disease Index (Ramfjord) has proven effective in the evaluation of generalized patterns of disease.

  9. Accidentabilidad por exposicion muco cutanea a fluidos biologicos en profesionales de laboratorios clinicos

    National Research Council Canada - National Science Library

    Panunzio, Amelia; Nunez-Barboza, Milagros; Fuentes, Belkis; Parra, Irene; Sirit, Yadira; Villarroel, Francis; Velasco, Doris; Garcia, Lenis

    2008-01-01

    Se determino la exposicion laboral accidental a fluidos biologicos por contacto muco-cutaneo y factores asociados, mediante un estudio descriptivo dirigido a una muestra de 156 bioanalistas adscritos...

  10. [Clinico-psychopathological characteristics of states in patients with suicidal attempts].

    Science.gov (United States)

    Ostroglazov, V G; Lisina, M A

    2000-01-01

    A total psychiatric examination of the persons, after attempted suicides was performed during a month of stay in the department of resuscitation of the N.V. Sklifosovsky Institute for the Emergency Medical care. In all the patients some mental pathology was found that took place in the moment of suicide and long before it. In most of the cases the disorders of either affective (48.7%) or schizophrenic (38.5%) spectrum were diagnosed. Psychogenic reactions to stress and personality disorders were in only 10.2% of the patients. In most of the patients (74.7%) a mental disease wasn't diagnosed before in spite of its long duration (11.5 years on the average).

  11. THE STUDY OF CLINICO-AETIOLOGICAL PROFILE OF PANCYTOPENIA IN ELDERLY POPULATION

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    Vijayashree Thyagaraj

    2017-06-01

    Full Text Available BACKGROUND Pancytopenia is a common problem in clinical practice. Pancytopenia is defined as haemoglobin less than 9 gm/dL, total leucocyte count less than 4,000/dL and platelet count less than 1 lakhs/dL. Causes of pancytopenia vary from nutritional deficiencies, bone marrow failure status and malignancies. Pancytopenia is a common problem in geriatric population also. In this study, we try to find common causes of pancytopenia in geriatric population in a tertiary care hospital. MATERIALS AND METHODS 40 consecutive patients who are more than 60 years of age attending General Medicine Outpatient Department were included in the study. Pancytopenia due to acute infections like viral fever and sepsis were excluded. Patients suspected to be having malignancies like lymphadenopathy and hepatosplenomegaly were also excluded. These patients were subjected to detailed history taking and clinical examination. Routine investigations like complete blood count, peripheral smear, reticulocyte count, Coombs test, serum cobalamin levels, renal function tests and liver function tests were done. Bone marrow examination was done in cases where indicated. Upper gastrointestinal endoscopy and anti-intrinsic factor antibody and antiparietal cell antibody were done where indicated. RESULTS Out of 40 patients included in the study, 25 were males and 15 were females. 28 patients were aged between 60-70 years, 10 patients between 70-80 years and 2 were more than 80 years old. Mean age of the patients was 68 years. Fatigue was the most common symptom (70%, fever was seen in 15% cases, mild cognitive impairment was reported in 10% patients and bleeding manifestations were seen in 5% cases. Most common cause of pancytopenia was cobalamin deficiency (60%. Others causes were aplastic anaemia (7.5%, chronic liver disease (5%, myelodysplasia (5%, drug induced (2.5% and HIV associated (2.5% cases. In this study, we saw that most common of pancytopenia was cause of cobalamin deficiency. We found that mean MCV was 88 fL (p=0.2 in all these patients. CONCLUSION Vitamin B12 deficiency is the most common cause of pancytopenia in elderly population. Symptoms of vitamin B12 deficiency maybe vague in elderly. High index of suspicion is required for the diagnosis. Mean corpuscular volume may not be raised in all cases. Hence, all patients in geriatric population presenting with must be tested for vitamin B12 deficiency.

  12. Clinico-aetiologic profile of macrocytic anemias with special reference to megaloblastic anemia.

    Science.gov (United States)

    Unnikrishnan, Vineetha; Dutta, Tarun Kumar; Badhe, Bhawana A; Bobby, Zachariah; Panigrahi, Ashish K

    2008-12-01

    This study was conducted to study the clinical and laboratory parameters in patients with macrocytic anemia and to determine the etiology of macrocytic anemia with special reference to megaloblastic anemia. This study was a cross-sectional descriptive study carried over a period of 18 months on 60 adult patients (age ≥13 years) of macrocytic anemia. Macrocytic anemia was identified when peripheral blood examination showed anemia with a mean red blood corpuscular volume of >95 fl. The most common cause of macrocytic anemia was megaloblastic anemia (38.4%). The major causes of nonmegaloblastic macrocytic anemia were primary bone marrow disorders (35%), liver diseases (15%) and hemolytic anemia (8.3%). There was a significant male preponderance in the study (65%). The megaloblastic anemias observed were due to either vitamin B(12) deficiency (78.3%) or combined B(12) and folate deficiency (21.7%). A significant proportion of non-vegetarians (73.9%) had megaloblastic anemia. Patients with an MCV of >110fl were more likely to have megaloblastic anemia (p value 0.0007). Three patients (mean age 55 years) with a megaloblastic marrow did not respond to vitamin replacement and were found to have myelodysplastic syndrome. Megaloblastic anemia due to Vitamin B(12) or folate deficiency remains the most important cause of macrocytic anemia. In settings with limited laboratory facilities, a therapeutic trial of vitamins B(12) or folic acid is useful in determining the specific vitamin deficiency.

  13. Clinico-pathological study of appendicitis in a tertiary centre in Vindhya region, Madhya Pradesh, India

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    Priyank Sharma

    2016-07-01

    Conclusions: In this study we found that clinical score is a simple, rapid and non-invasive method to early diagnosis of appendicitis. TLC are inflammatory marker are also useful in early diagnosis of acute appendicitis. Ultrasound abdomen is also useful to confirm the diagnosis. The majority of our patients presented early disease. Conservative approach of treatment gave positive response and then we planned for elective appendectomy after regular interval. Because of these negative appendectomy rate are decreasing and morbidity period are also decreasing pre or post appendectomy. There was much less post-operative complication, which were higher in emergency appendectomy. In our study we concluded that timely intervention reduce the negative appendectomy and reduce the length of morbidity. [Int J Res Med Sci 2016; 4(7.000: 2914-2920

  14. [Clinico-histopathological correlations of venous wall modifications in chronic venous insufficiency].

    Science.gov (United States)

    Mironiuc, A; Palcau, L; Andercou, O; Rogojan, L; Todoran, M; Gordan, G

    2008-01-01

    The interest manifested for the conjunctive tissue pathology leaded to the study of the structural disorder that appears in the varicose veins walls. The study is a prospective one initiated in March 2007 made on 11 patients with varicose disease hospitalized at Cluj-Napoca within Surgery Clinic no. II. The purpose of this study is to point out the histopathological modifications in the varicose venous wall (great saphenous vein cross, communicating veins, perforating veins), as well as the correlation of histopathological results with the evolutive stage of chronic vein insufficiency (CEAP classification) and with the clinical score at these patients. The histopathological (HP) results for 2 of the patients revealed hypertrophy of the media, intimal hyperplasia (stage II) corresponding to a CEAP 3. Six patients were integrated in HP stage III due to the partial intimal fibrosis corresponding to a CEAP 6 for one case, CEAP 4 one case, CEAP 3 four cases. One patient had HP stage I with CEAP 3 and two patients had HP stage IV corresponding to CEAP 5, respectively CEAP 6.

  15. Clinico-Mycological Study Of Superficial Fungal Infection In Children In An Urban Clinic In Kolkata

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    Barbhuiya Joyashree Nath

    2002-01-01

    Full Text Available Seventy children up to the age of 12 years who were suffering from dermatophytosis, candidiasis or pityriasis versicolor were studied clinically and mycologically. Dermatophytosis was the major group, which constituted 52.86% of children. It was followed by candidiasis that constituted 40% of children and pityriasis versicolor was the least, being 7.14% of children. Amongst the clinical types of dermatophytosis, tinea capitis was the commonest (32.43% followed by tinea corporis (27.03%. Candidial intertrigo was the commonest (42.86% from of candidiasis, followed by diaper dermatitis (32.14%. Most susceptible age group was school going children. Peak incidence of infection was during the months of June to September. T rubrum was the commonest dermatophyte isolated in culture. C. albicans was the most common species of candida isolated in culture.

  16. CLINICO - MYCOLOGICAL STUDY OF SUPERFICIAL FUNGAL INFECTIONS IN COASTAL KARNATAKA, INDIA

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    Sweta R.

    2013-10-01

    Full Text Available ABSTRACT: Cutaneous fungal infections are common in coastal Karnataka owing to its tropical and humid climate. The organisms causing these infections commonly are dermatophytes, non dermatophytes and yeasts. This study aims to determine the p revalence of cutaneous mycosis, with their different clinical types and etiological agents, and correlate the findings. A total of 96 patients were included in our study, all of them attending dermatology OPD at a tertiary hospital in Mangalore with clinic ally suspected tinea corporis, tinea cruris, tinea pedis, tinea capitis, tinea mannum, onychomycosis, candidiasis and pityriasis versicolor. The study revealed male to female ratio being 0.74:1. The leading diagnosis was pityriasis versicolor, the commones t organism isolated was C. albicans; and the commonest site involved is groin and skin flexures. This study emphasizes utility of timely detection of cutaneous fungal infection in preventing transmission and spread of KEYWORDS: Fungal infe ctions; Dermatophytes; Pityriasis versicolor such infections

  17. A Clinico-bacteriological study of primary pyodermas of children in Pondicherry

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    Mathew Mariette

    1992-01-01

    Full Text Available One hundred and twenty children selected at random and diagnosed as having Primary Pyoderma lesions were studied for clinical patterns and bacteriological profile. Sixty percent of the cases were girls. The commonest clinical type was impetigo contagiosa (45% followed by folliculities of the scalp (44.2%. Staphylococcus aureus was the etiological agent in 47.5% while 26.7% of the cases were due to mixed infection along with Streptococcus pyogenes. Almost all strains were sensitive to Erythromycin and Gentamycin. The highest resistance was to Penicillin (79.3% followed by Ampicillin (73.9% and Tetracycline (42.3%.

  18. Aspectos clinicos da neurocisticercose: análise de 500 casos

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    Osvaldo M. Takayanagui

    1983-03-01

    Full Text Available Analisamos as manifestações clínicas, os exames complementares e a evolução de 500 pacientes com neurocisticercose, atendidos pela Disciplina de Neurologia do Departamento de Neuropisiquiatria e Psicologia Médica da Faculdade de Medicina de Ribeirão Preto, no período de 1956 a 1979. Este material, no contexto da literatura consultada, constituiu-se na maior casuística clínica até agora apresentada. A neurocisticercose é grave endemia em nossa região, representando 2,7% dos atendimentos efetuados pela Disciplina de Neurologia e 7,5% das internações hospitalares. As formas clínicas mais comuns foram a epiléptica (64,8%, a de hipertensão intracraniana (35,6% e a meningítica (29%. Na radiografia simples do crânio evidenciou-se a presença de calcificações intracranianas com morfologia sugestiva de cisticercos em 47,6%. O exame do LCR apresentou anormalidades em 81,3%: hipercitose em 60,9%, hiperproteinorraquia em 49,1% e hipertensão em 29%. A eosinofilorraquia ocorreu em 41,9%. A positividade na reação de Weinberg esteve presente em 62,6%. A terapêutica da neurocisticercose é fundamentalmente sintomática. Discutimos o valor dos diferentes medicamentos e do tratamento cirúrgico na neurocisticercose, chegando à conclusão de que nenhum deles é eficaz a longo prazo. Enquanto as pesquisas não revelarem drogas realmente eficientes, somente a educação sanitária poderá controlar esta endemia, que atinge entre nós, tão sombrias perspectivas.

  19. Bilateral ovarian primary Burkitt′s lymphoma in a child: A clinico-radio-pathological evaluation

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    Gujarathi Aditi

    2015-01-01

    Full Text Available Ovarian neoplasms are rare in children. Though ovarian involvement by malignant lymphoma is known to occur in late stages of disseminated nodal disease, primary ovarian lymphoma is a rare entity. We came across a case of a 9-year-old female who came with complaints of dull aching abdominal pain, mainly in the suprapubic region, low grade fever and abdominal distension since 20 days. Ultrasonography revealed two well-defined, mixed echogenic masses in both adnexae. Multiple well-defined mixed echogenic lesions were also seen on the surface of liver with omental thickening and nodularity. Computerized tomography as well as magnetic resonance imaging was done for further evaluation. Ultrasound guided biopsy was performed. The diagnosis of Burkitt′s lymphoma involving bilateral ovaries was established after histological, immunohistochemistry, and tumor markers correlation.

  20. CLINICO - PATHOLOGICAL STUDY MANAGEMENT AND OUTCOME OF NECROTIZING SOFT TISSUE INFECTION

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    Rajesh Kumar

    2015-07-01

    Full Text Available INTRODUCTION: Necrotizing soft tissue infection (NSTI is a broad term applied to infections of "flesh eating bacteria" that may cause cellulitis, fascitis, or myositis. NSTI's can rapidly progress to systemic toxicity, resulting in major morbidity and mortality without prompt recognition and treatment. MATERIAL & METHODS: In the present study, all the cases of necrotizing soft tissue infection attending OPD, emergency & a dmitted in ward of L. L. R. And associated hospitals from Dec. 2012 to June 2014 were selected for the study. The general condition of the patient was noted with special reference to temperature, respiratory rate, pulse rate, blood pressure and signs of to xemia. All routine hematological and biochemical tests were done. Pus and excised tissue sent in sterile container for Gram staining and culture & Histopatholigical examination. RESULTS: In our study we have found that with increasing age the incidence of necrotizing soft tissue infection rises and 9 out of 44 patients expired which is 20.45% of total patient studied. Most common bacteria identified in this study was Group - A  hemolytic streptococcus (52.27%. In most of the case (72.72% infection was found to be poly - microbial (32 out of 42 and only ten out 42(22.72% were mono microbial. Increased mortality was seen in patient associated with diabetes mellitus shock renal dis - function anemia and coagulopathy. CONCLUSION: Earliest possible patient sho uld be treated by extensive debridement broad spectrum antibiotics. Wound closure or grafting should only be performed when there is no longer evidence of necrotic tissue and the patient has been adequately resuscitated.

  1. Schwannoma of the epiglottis: case report focusing on clinico-pathological aspects.

    Science.gov (United States)

    Saita, V; Azzolina, A; Galia, A; Fraggetta, F

    2005-12-01

    Laryngeal schwannomas are uncommon lesions with only few cases reported. Herein we present a further case of a schwannoma of the epiglottis, occurring in a 62-year-old with a clinical history of a cutaneous malignant melanoma and laryngeal glottic keratosis. The schwannoma was incidentally discovered as a small polypoid lesion located on the laryngeal surface of the epiglottis and was removed endoscopically. The procedure was uneventful and the patient is well six months later. Authors focus on the diagnostic and therapeutic options for this unusual lesion and discuss the differential diagnosis of the spindle cell proliferation of the larynx.

  2. RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma.

    Science.gov (United States)

    Romei, Cristina; Elisei, Rossella

    2012-01-01

    Thyroid carcinoma is the most frequent endocrine cancer accounting for 5-10% of thyroid nodules. Papillary histotype (PTC) is the most prevalent form accounting for 80% of all thyroid carcinoma. Although much is known about its epidemiology, pathogenesis, clinical, and biological behavior, the only documented risk factor for PTC is the ionizing radiation exposure. Rearrangements of the Rearranged during Transfection (RET) proto-oncogene are found in PTC and have been shown to play a pathogenic role. The first RET rearrangement, named RET/PTC, was discovered in 1987. This rearrangement constitutively activates the transcription of the RET tyrosine-kinase domain in follicular cell, thus triggering the signaling along the MAPK pathway and an uncontrolled proliferation. Up to now, 13 different types of RET/PTC rearrangements have been reported but the two most common are RET/PTC1 and RET/PTC3. Ionizing radiations are responsible for the generation of RET/PTC rearrangements, as supported by in vitro studies and by the evidence that RET/PTC, and particularly RET/PTC3, are highly prevalent in radiation induced PTC. However, many thyroid tumors without any history of radiation exposure harbor similar RET rearrangements. The overall prevalence of RET/PTC rearrangements varies from 20 to 70% of PTCs and they are more frequent in childhood than in adulthood thyroid cancer. Controversial data have been reported on the relationship between RET/PTC rearrangements and the PTC prognosis. RET/PTC3 is usually associated with a more aggressive phenotype and in particular with a greater tumor size, the solid variant, and a more advanced stage at diagnosis which are all poor prognostic factors. In contrast, RET/PTC1 rearrangement does not correlate with any clinical-pathological characteristics of PTC. Moreover, the RET protein and mRNA expression level did not show any correlation with the outcome of patients with PTC and no correlation between RET/PTC rearrangements and the expression level of the thyroid differentiation genes was observed. Recently, a diagnostic role of RET/PTC rearrangements has been proposed. It can be searched for in the mRNA extracted from cytological sample especially in case with indeterminate cytology. However, both the fact that it can be present in a not negligible percentage of benign cases and the technical challenge in extracting mRNA from cytological material makes this procedure not applicable at routine level, at least for the moment.

  3. [Clinico-psychopathologic varieties of the acute Kandinsky-Clerambault syndrome in schizophrenia].

    Science.gov (United States)

    Dikaia, V I

    1985-01-01

    Acute cases of the Kandinsky-Clerambault syndrome first manifested in adulthood were studied in schizophrenic patients. On the basis of the clinical mechanisms of the development of psychosis and the specific features of acute delirious disturbances in the structure of psychosis 3 clinical variants of the acute syndrome of psychic automatism were identified: developing according to the type of reaction in the structure of acute paranoid (the first variant), according to the regularities of endogenic paroxysm in the picture of acute sensory delirium (the second variant) and according to the mechanism of exacerbation of chronic delirium entering the structure of acute interpretative delirium (the third variant).

  4. CLINICO-PATHOLOGICAL OBSERVATIONS OF PIGEONS (COLUMBA LIVIA SUFFERING FROM NEWCASTLE DISEASE

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    S. Shaheen, A. D. Anjum and F. Rizvi

    2005-01-01

    Full Text Available A survey was conducted to study clinical signs, gross and histopathological lesions in pigeons with naturally occurring Newcastle disease. For this purpose, 30 pigeon lofts were visited. Among these, 14 lofts showed clinical signs of Newcastle disease, including mainly greenish white mucoid diarrhoea and nervous signs with high morbidity and mortality. Postmortem examination of affected birds showed lesions mainly in brain, liver, kidneys and spleen. Amongst various organs, kidneys were more frequently involved. Histopathological changes were also observed in lungs, liver, kidneys, brain and spleen. The results showed that the Newcastle disease virus was widespread in pigeons locally and caused heavy mortality. No preventive measures or vaccination is being adopted by pigeon fanciers to control the disease.

  5. Clinico-embryological perspective of a rare accessory brachial muscle with possible musculocutaneous nerve compression.

    Science.gov (United States)

    Mehta, V; Yadav, Y; Arora, Jyoti; Kumar, H; Suri, R K; Rath, G

    2009-03-01

    Both brachialis and biceps brachii are primary flexors of the arm and elbow from the biomechanical perspective. Numerous reports exist in anatomical literature regarding accessory heads of biceps brachii, although such accessory bellies in relation to brachialis muscle are less frequently elucidated. We report a unilateral case of a rare accessory muscle interposed between the biceps brachii and brachialis, having the musculocutaneous nerve (MCN) entrapped between the two. Furthermore, the muscle divided into two slips, upper slip was attached to biceps brachii and the other gained insertion to the brachial fascia. Innervation to this accessory muscle was derived from MCN. The embryological basis for such supernumerary muscle is discussed. Additionally, the case is considered under surgical and clinical perspective, highlighting the importance of familiarity with such variations. Anatomical variations of the brachial musculature may cause diagnostic perplexities while interpreting MRI or CT scans.

  6. A Clinico-Pathologic Study of 142 Orofacial Tumors in Children and Adolescents in Southern Iran

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    Mohammad-Javad Ashraf

    2011-09-01

    Full Text Available Objective:The prevalence, patients age and sex and the site of the lesions are important factors for diagnosis and they may be different in various populations. The aim of this study was to determine the type and distribution of orofacial tumors among children and adolescents in an Iranian population Methods:In this retrospective, case series study, data about the type, age, sex and site of 142 tumors in patients ≤18 years afflicted with orofacial neoplasms referred 2005-2009 to two referral centers in Shiraz, Southern Iran, were collected and analyzed. Findings:There were 142 (2.8% tumors among the subjects. The most common types of benign and malignant tumors were odontoma and lymphoma in children and pleomorphic adenoma and rhabdomyosarcoma in adolescents. Parotid and posterior parts of the mandible were the most common sites of soft tissue and intrabony tumors. In the oral cavity, the palate was the most common affected site. The tumors were found in boys with higher frequency (Male:Female ratio was 1.4:1. Conclusion:The observed differences in tumor type and distribution in comparison with previous studies may be attributed to genetic and geographic variations in the populations; however the design and methods of the studies are different, too.

  7. Clinico-dynamic features of psychopathological disorders at heroin addiction young age

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    Vasila Abdullaeva

    2012-05-01

    Full Text Available There were studied 120 patients with heroin addiction at the age of 17 to 26 years. Prescription of heroin abuse at the time of initial examination ranged from 8 months to 5 years. The greatest number of patients made those receiving the drug from 1 to 3 years. It is established that the premorbid personality characteristics in patients with heroin addiction affect the formation of remission and determine the extent and nature of medico-social consequences of the disease. Anxieties are the leading clinical and dynamic psychopathology in heroin addiction. They play an important role in the syndrome of pathological craving for psychoactive substances and determine the prognosis of the disease.

  8. Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis

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    Sudhir Babu Karri

    2015-01-01

    Full Text Available Aims: To study the histological features on muscle biopsy and correlate them with clinical features, other laboratory data in adult patients to make a diagnosis of dermatomyositis (DM, applying the European Neuromuscular center (ENMC criteria. Materials and Methods: Adult patients who fulfilled clinical, laboratory, and muscle biopsy findings according to ENMC criteria for DM during the period 2010-2013 were included in the study. Cryostat sections of muscle biopsy were reviewed with emphasis on Perifascicular atrophy (PFA, perivascular/endomysial inflammation. Muscular dystrophies and metabolic myopathies were excluded by appropriate immunohistochemistry and special stains. Results: The diagnosis of adult DM was made in 45 patients out of 170 clinically suspected idiopathic inflammatory myopathies. These included 33 definite, 4 probable, 7 possible sine dermatitis, and 1 amyopathic DM. All patients with definite DM had typical rash and proximal muscle weakness and muscle biopsy showed PFA with or without inflammation. Thirteen patients had quadriparesis, neck muscle weakness, dysphagia/dysphonia at presentation. Patients with probable DM had rash and showed perivascular/endomysial inflammation with no PFA. Possible DM sine dermatitis showed PFA with perivascular/endomysial infiltrates. One patient of amyopathic DM had typical heliotrope rash and characteristic skin biopsy. Conclusions: Histological features are important for the diagnosis of DM. Relying on PFA for diagnosis of definite DM underestimates the true frequency of DM.

  9. CLINICO – HISTOPATHOLOGICAL CORRELATION IN LEPROSY: A TERTIARY CARE HOSPITAL BASED STUDY

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    Deeptara Pathak Thapa

    2013-07-01

    Full Text Available Introduction: Leprosy is a chronic infectious disease affecting mainly cutaneous and peripheral nervous system. Histopathology is an important tool to diagnosis leprosy in situation where it mimics other clinical condition. This study was conducted to know the correlation between clinical and histopathological diagnosis of Leprosy. Material and Methods: This was a retrospective study and patients were enrolled in whom leprosy was clinically diagnosed or suspected and histo-pathological examinations were carried upon. Results: A total of 71 patients were studied. Of them 48 patients (67.6% were males and rest 23 (32.39% patients were females. Mean age of patients at presentation was 37.85 +/- 2.021 years. Clinically in 42 patients (59.1% type of leprosy could not be specified. Borderline tuberculoid was diagnosed in 7 patients (9.8%, Tuberculoid in 6(8.5%, Relapse in 3(4.2%, lepromatous in 6(8.5% and Borderline, borderline lepromatous 1(1.4, Indeterminate 1 patient (1.4%. In 7% cases, Hansens disease was considered as differential diagnosis along with other clinical conditions. In 47% cases, data was not available. On histopathological evaluation on skin biopsies, epidermal changes seen were 29.5%. Of the total 71 patient, dermal changes seen were granuloma (42%, dermal infiltrate (11%, adnexal infiltrate (7%, nerve infiltrate (11%, adnexal with nerve infiltrate (6%, perivascular with adnexal infiltrate (20% and nonspecific (3%. Dermal infiltrates in 46.4% cases constituted of lympho-histiocytes. In 48 patients (69% leprosy was histopathologically con