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Sample records for clinical pathology ecvcp

  1. Establishment of the European College of Veterinary Clinical Pathology (ECVCP) and the current status of veterinary clinical pathology in Europe

    DEFF Research Database (Denmark)

    O'Brien, P.J.; Fournel-Fleury, C.; Bolliger, Adrian Marc;

    2007-01-01

    After 5 years of development, the European College of Veterinary Clinical Pathology (ECVCP)was formally recognized and approved on July 4, 2007 by the European Board of Veterinary Specialisation (EBVS), the European regulatory body that oversees specialization in veterinary medicine and which has...... congresses and a joint journal (with the American Society for Veterinary Clinical Pathology) for communication of scientific research and information; the College also maintains a website, a joint listserv, and a newsletter; 6) collaboration in training and continuing education with relevant colleges...... in medicine and pathology; 7) development and strict adherence to a constitution and bylaws compliantwith the EBVS; and 8) emonstration of compelling rationale, supporting data, and the support ofmembersandother colleges for independence as a specialtycollege.FormalEBVS recognitionofECVCPas the regulatory...

  2. American Society for Clinical Pathology

    Science.gov (United States)

    ... With the National Cancer Institute for Inaugural Global Pathology Conference March 2016 OneLab Memo ASCP Action Alert - ... 2016 Copyright © 2016 by American Society for Clinical Pathology. All Rights Reserved. Terms of Use About ASCP ...

  3. Clinical pathology services: remapping our strategic itinerary.

    Science.gov (United States)

    Blanckaert, Norbert

    2010-07-01

    Both technological advances and economic drivers have led to major changes in clinical laboratories across the world, with vastly improved testing productivity. However, the production process capability advances have far outpaced the clinical pathologists' success in assuring optimal test utilization and interpretation. While productivity of 'commodity' testing increases, our healthcare value productivity decreases. Such developments constitute a serious threat to our clinical pathology specialty, not only because pathologists may lose direct control of the commodity testing production activities, but also because the present evolution exposes a failure of our core clinical activities, the pathologist's knowledge processes that translate 'commodity' results into medical outcomes optimization. At a time when a revolution in health care organization is inescapable in the years ahead, clinical pathology must proceed from a merely reactive strategy (to fulfill the 'more with less' demands) to a proactive strategy where we build excellence and visibility in knowledge services on a strong foothold of operational excellence. Based on a Strengths-Weaknesses-Opportunities-Threats analysis, we argue that clinical pathology should safeguard and expand its healthcare value productivity by assuming leadership in building integrated laboratory services networks. We also suggest that the core knowledge processes deserve a system approach, for example, by applying a risk-based quality management system. PMID:20491600

  4. Clinical predictive factors of pathologic tumor response

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    Choi, Chi Hwan; Kim, Won Dong; Lee, Sang Jeon; Park, Woo Yoon [Chungbuk National University College of Medicine, Cheongju (Korea, Republic of)

    2012-09-15

    The aim of this study was to identify clinical predictive factors for tumor response after preoperative chemoradiotherapy (CRT) in rectal cancer. The study involved 51 patients who underwent preoperative CRT followed by surgery between January 2005 and February 2012. Radiotherapy was delivered to the whole pelvis at a dose of 45 Gy in 25 fractions, followed by a boost of 5.4 Gy in 3 fractions to the primary tumor with 5 fractions per week. Three different chemotherapy regimens were used. Tumor responses to preoperative CRT were assessed in terms of tumor downstaging and pathologic complete response (ypCR). Statistical analyses were performed to identify clinical factors associated with pathologic tumor response. Tumor downstaging was observed in 28 patients (54.9%), whereas ypCR was observed in 6 patients (11.8%). Multivariate analysis found that predictors of downstaging was pretreatment relative lymphocyte count (p = 0.023) and that none of clinical factors was significantly associated with ypCR. Pretreatment relative lymphocyte count (%) has a significant impact on the pathologic tumor response (tumor downstaging) after preoperative CRT for locally advanced rectal cancer. Enhancement of lymphocyte-mediated immune reactions may improve the effect of preoperative CRT for rectal cancer.

  5. Capturing clinically significant eating pathology in adolescence

    Directory of Open Access Journals (Sweden)

    Rasmus Isomaa

    2013-06-01

    Full Text Available Background and Objectives: Several large-scale studies on adolescent mental health have used questionnaire items derived from DSM-IV criteria to assess eating disorders. The aim of the present brief report was to analyse the capacity of self-reported eating disorder symptoms to capture clinically significant eating disorders. Methods: All pupils in the ninth grade (N = 606, response rate 98.2%, mean age = 15.4 of comprehensive school in a defined area were invited to participate in the study. Adolescents who reported some form of eating pathology (n = 126 were invited to an interview (RAB. Results: Anorexia based on the self-report resulted in a positive predictive value of 60.0% for lifetime and 20% for current eating disorder, when compared to the results in the RAB. No case of BN was detected by the RAB, but self-reported BN symptoms were predictive of both EDNOS and subclinical eating pathology. Conclusions: Self-reported eating disorder symptoms seem to be relatively good predictors of broadly defined eating pathology, but may result in overestimation of clinical conditions.

  6. Hypersensitivity pneumonitis: Radiological, clinical and pathologic evaluation

    International Nuclear Information System (INIS)

    This paper is to evaluate radiological features of hypersensitivity pneumonitis, correlated with clinical and pathologic findings. Patients consisted of 2 men and 3 women, aged 23-51 years old (average 41). Diagnosis was based on the presence of suggestive clinical and radiological findings (chest radiography, high resolutional CT, gallium scintigraphy), and lung biopsy showing characteristic histological features. All patients complained of external dyspnea and three patients experienced coughing. On the pulmonary function test, four patients revealed restrictive pattern and one patients was normal. Results of bronchoalveolar lavage, available in four patients, revealed lymphocytosis in three patients and normal finding in one patients. Chest radiographs showed ground glass opacity or diffuse nodular densities. On the HRCT,diffuse nodular opacity and ground glass and opacity were seen in variable features. All 4 patients had diffuse increased uptake on the gallium scan. On lung biopsy, a combination of histologic findings showed cellular bronchiolitis, diffuse interstitial infiltrates and non-necrotizing granulomas, consistent with diagnosis of hypersensitivity pneumonitis. Hypersensitively pneumonitis could be diagnosed with these radiological, clinical and pathological findings

  7. Clinical Pathological Analysis of Synovial Sarcoma

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    OBJECTIVE To investigate the clinical diagnosis and differential diagnosis of synovial sarcoma (SS).METHODS A total of 41 paraffin-embedded synovial sarcoma samples were examined by H&E staining, immunohistochemistry staining and the reverse transcriptase polymerase chain reaction (RT-PCR), in order to provide a scientific bases for diagnosis and differential diagnosis.RESULTS Twelve cases were a biphasic type, 22 cases were a monophasic fibrous type, and 7 cases were a poorly differentiated type. Thirty-six cases were both CK (and/or EMA) and Vim positive. Five cases were only Vim positive. A SYT-SSX fusion gene was detected in 18 cases by RT-PCR.CONCLUSION By observation of the histomorphology, immunohistochemistry markers and detection of a SYT-SSX fusion gene, we can make a clinical pathological diagnosis of synovial sarcoma.

  8. Radioisotope diagnostics of lung pathology in children by clinical data

    International Nuclear Information System (INIS)

    Analysis of clinical data (118 patients) shows convincingly that radioisotope investigations play an important role in recognition of lung pathology in children. Diagnostic value of the method increases especially in those cases when clinical-roentgenological diagnostics of this pathology turns out to be difficult. Expressiveness of scannographic signs permits to differentiate different forms of lung pathology and alongside with this to observe dynamics of pathological processes in lungs which makes it possible to perform selective therapeutic tactics in either concrete situation

  9. Clinical pathology of primary bile reflux gastritis

    Directory of Open Access Journals (Sweden)

    Ping YAO

    2011-05-01

    Full Text Available Objective To analyze the clinical and pathological features of primary bile reflux gastritis(BRG.Methods Endoscopy,Helicobacter pylori(H.pylori detection,and histopathologic examination were performed in 218 patients with primary BRG(observed group and 236 patients with simple chronic gastritis(SCG,control group as identified by gastroscope in order to analyze the endoscopic abnormalities,the frequency of H.pylori infection,pathological features and scores of inflammation.Results The frequency of H.pylori infection was 39.0%(85/218 in the observed group,which was significantly lower than that in the control group [52.1%(123/236].The topographic abnormalities of the antral mucosa as detected by gastroscopy,i.e.,congestion,hemorrhagic spots,erosion were not significantly different between BRG and SCG patients(P > 0.05.The scores of chronic and active inflammation were higher in patients when H.pylori infection was present than in patients without H.pylori infection in both groups(P < 0.05.The scores of inflammation,the detection rates of the antral intestinal metaplasia,antral atrophy and atypical hyperplasia were all higher in observed group than in control group(P < 0.05.The incidence of lengthening of gastric pits,telangiectasis or interstitial edema in BRG patients was also significantly higher than those in SCG patients(P < 0.05.Conclusions Primary BRG shows features of chemical gastritis with a higher tendency toward mucosal atrophy,intestinal metaplasia and atypical hyperplasia.Gastropic examination and biopsy should be emphasized.

  10. Clinical, pathological and sonographic characteristics of unexpected gallbladder carcinoma

    OpenAIRE

    Jin-huan WANG; Liu, Bo-Ji; Xu, Hui-Xiong; Sun, Li-ping; Li, Dan-Dan; Guo, Le-Hang; Liu, Lin-Na; Xu, Xiao-Hong

    2015-01-01

    Objectives: To investigate the clinical, pathological, and sonographic characteristics of unexpected gallbladder carcinoma (UGC). Methods: Of 5424 patients who had undergone cholecystectomy from December 2006 to October 2013, 54 patients with primary gallbladder carcinomas confirmed by pathological diagnosis were identified. The patients were divided into two groups: diagnosed before operation (n=34) and UGC groups (n=20), of whom the clinical, pathological, and sonographic characteristics we...

  11. A Guide to Clinical Services in Speech Pathology and Audiology.

    Science.gov (United States)

    Rehabilitation Services Administration (DHEW), Washington, DC.

    A listing of speech pathology and audiology services in the United States, the guide includes the names of 910 clinics and of 216 members of the American Speech and Hearing Association who are engaged in full time private practice. Arranged geographically, by state and city, the guide specifies the following for each clinic: official name,…

  12. A core curriculum for clinical fellowship training in pathology informatics

    OpenAIRE

    David S McClintock; Levy, Bruce P.; Lane, William J; Lee, Roy E.; Baron, Jason M.; Klepeis, Veronica E.; Maristela L Onozato; JiYeon Kim; Anand S Dighe; Beckwith, Bruce A; Frank Kuo; Stephen Black-Schaffer; Gilbertson, John R.

    2012-01-01

    Background: In 2007, our healthcare system established a clinical fellowship program in Pathology Informatics. In 2010 a core didactic course was implemented to supplement the fellowship research and operational rotations. In 2011, the course was enhanced by a formal, structured core curriculum and reading list. We present and discuss our rationale and development process for the Core Curriculum and the role it plays in our Pathology Informatics Fellowship Training Program. Materials and Meth...

  13. Pseudolipoma of inverted Meckel's diverticulum: clinical, radiological and pathological correlation

    International Nuclear Information System (INIS)

    Three cases of isolated inverted Meckel's diverticulum are described. In two cases an initial pathological diagnosis of small bowel lipoma was suggested. In a third case central fat was demonstrated on CT and peristalsis of the intraluminal polypoid mass was observed during US examination. In all three cases small bowel enema examination demonstrated the lesion. Correlation of the clinical, radiological and pathological features is emphasised, as this will allow the correct diagnosis. (orig.). With 4 figs

  14. Erythromelalgia : Clinical aspects, pathology and therapy

    OpenAIRE

    2012-01-01

    List of papers. Papers I-IV and Appendix I-II are removed from the thesis due to copyright restrictions. Paper I Lalgaard OM, Seem E, Kvernebo K: Erythromelalgia: a clinical study of 87 cases. J Int Med 242:191-7, 1997 doi:10.1046/j.1365-2796.1997.00185.x Paper II Kalgaard OM, Clausen OP, Mellbye OJ, Hovig T, Kvernebo K: Nonspecific capillary proliferation and vasculopathy indicate skin hypoxia in erythromelalgia. Arch Dermatol 147(3):309-14,2011 doi:10.10...

  15. Clinical pathology interpretation in geriatric veterinary patients.

    Science.gov (United States)

    Metzger, Fred L; Rebar, Alan H

    2012-07-01

    Routine monitoring of clinicopathologic data is a critical component in the management of older patients because blood and urine testing allows the veterinarian to monitor trends in laboratory parameters, which may be the early indicators of disease. Laboratory profiling often provides an objective and sensitive indicator of developing disease before obvious clinical signs or physical examination abnormalities are observed. The primary key to the power of this evaluation is that the data are collected year after year during wellness checks and are examined serially. Chronic renal failure, chronic active hepatitis, canine hyperadrenocorticism, diabetes mellitus, and feline hyperthyroidism were reviewed and expected laboratory findings are summarized. PMID:22720804

  16. Capturing clinically significant eating pathology in adolescence

    OpenAIRE

    Rasmus Isomaa; Anna-Lisa Isomaa; Mauri Marttunen; Riittakerttu Kaltiala-Heino

    2013-01-01

    Background and Objectives: Several large-scale studies on adolescent mental health have used questionnaire items derived from DSM-IV criteria to assess eating disorders. The aim of the present brief report was to analyse the capacity of self-reported eating disorder symptoms to capture clinically significant eating disorders. Methods: All pupils in the ninth grade (N = 606, response rate 98.2%, mean age = 15.4) of comprehensive school in a defined area were invited to participate in the study...

  17. Spinocerebellar degeneration: Discrepancies between clinical and pathological diagnoses.

    Science.gov (United States)

    Yamada, Mitsunori; Toyoshima, Yasuko; Makifuchi, Takao; Kakita, Akiyoshi; Takahashi, Hitoshi

    2016-08-01

    To improve the diagnostic accuracy of sporadic spinocerebellar degeneration (SCD), we assessed the clinical and pathological data of 1494 consecutive autopsy cases. The number of patients who received a diagnosis of sporadic SCD (including multiple system atrophy) either clinically or pathologically was 19 (1.3%). We identified six cases with clinical misdiagnoses of SCD that were confirmed pathologically as progressive supranuclear palsy (PSP, four cases), basilar artery thrombosis (one case) and unclassified tauopathy (one case). The total number of patients who received a clinical diagnosis of sporadic SCD was 93 and the positive predictive value was 93.5%. We also identified 13 autopsy cases that were pathologically confirmed as SCD, but had been clinically misdiagnosed as having other disorders. Their clinical diagnoses comprised progressive supranuclear palsy (five cases) and Parkinson's disease (PD, four cases), as well as parkinsonism with dementia, amyotrophic lateral sclerosis, paraneoplastic syndrome and multiple cerebral infarction (one case each). The results indicate that it is often difficult to distinguish PSP and PD from SCD, because of the atypical combination of symptoms or atypical timing of the appearance of symptoms, such as severe autonomic failure, cognitive impairment, poor L-dopa responsiveness, early cerebellar signs and obvious vertical gaze palsy. PMID:26556659

  18. Clinical surgical and pathological characterization of nodular thyroid disease

    International Nuclear Information System (INIS)

    Nodular thyroid disease is a worrisome endocrine problem due to its association with cancer. To characterize patients hospitalized with this condition according to clinical surgical and pathological aspects, as well as to determine the effectiveness of the cytology by fine-needle aspiration biopsy for diagnosis

  19. Neuronopathic Lysosomal Storage Diseases: Clinical and Pathologic Findings

    Science.gov (United States)

    Prada, Carlos E.; Grabowski, Gregory A.

    2013-01-01

    Background: The lysosomal--autophagocytic system diseases (LASDs) affect multiple body systems including the central nervous system (CNS). The progressive CNS pathology has its onset at different ages, leading to neurodegeneration and early death. Methods: Literature review provided insight into the current clinical neurological findings,…

  20. Proteomic tools in clinical tissues: unlocking the pathology archives

    OpenAIRE

    Faoro, Valentina

    1982-01-01

    Background: Clinical proteomics aims to characterize the protein networks altered by pathologic processes or therapeutic treatment, and to develop biomarker profiling technologies to promptly detect diseases and treat them more effectively. The challenge of translating proteomic profiling to the bedside lies in applying technologies for the analysis of human tissues, which are routinely obtained by biopsy or surgery, without substantially modifying the clinical workflow. Formalin-fixed and...

  1. Clinical fellowship training in pathology informatics: A program description

    Directory of Open Access Journals (Sweden)

    John R Gilbertson

    2012-01-01

    Full Text Available Background: In 2007, our healthcare system established a clinical fellowship program in pathology informatics. In 2011, the program benchmarked its structure and operations against a 2009 white paper "Program requirements for fellowship education in the subspecialty of clinical informatics," endorsed by the Board of the American Medical Informatics Association (AMIA that described a proposal for a general clinical informatics fellowship program. Methods: A group of program faculty members and fellows compared each of the proposed requirements in the white paper with the fellowship program′s written charter and operations. The majority of white paper proposals aligned closely with the rules and activities in our program and comparison was straightforward. In some proposals, however, differences in terminology, approach, and philosophy made comparison less direct, and in those cases, the thinking of the group was recorded. After the initial evaluation, the remainder of the faculty reviewed the results and any disagreements were resolved. Results: The most important finding of the study was how closely the white paper proposals for a general clinical informatics fellowship program aligned with the reality of our existing pathology informatics fellowship. The program charter and operations of the program were judged to be concordant with the great majority of specific white paper proposals. However, there were some areas of discrepancy and the reasons for the discrepancies are discussed in the manuscript. Conclusions: After the comparison, we conclude that the existing pathology informatics fellowship could easily meet all substantive proposals put forth in the 2009 clinical informatics program requirements white paper. There was also agreement on a number of philosophical issues, such as the advantages of multiple fellows, the need for core knowledge and skill sets, and the need to maintain clinical skills during informatics training. However

  2. A core curriculum for clinical fellowship training in pathology informatics

    Directory of Open Access Journals (Sweden)

    David S McClintock

    2012-01-01

    Full Text Available Background: In 2007, our healthcare system established a clinical fellowship program in Pathology Informatics. In 2010 a core didactic course was implemented to supplement the fellowship research and operational rotations. In 2011, the course was enhanced by a formal, structured core curriculum and reading list. We present and discuss our rationale and development process for the Core Curriculum and the role it plays in our Pathology Informatics Fellowship Training Program. Materials and Methods: The Core Curriculum for Pathology Informatics was developed, and is maintained, through the combined efforts of our Pathology Informatics Fellows and Faculty. The curriculum was created with a three-tiered structure, consisting of divisions, topics, and subtopics. Primary (required and suggested readings were selected for each subtopic in the curriculum and incorporated into a curated reading list, which is reviewed and maintained on a regular basis. Results: Our Core Curriculum is composed of four major divisions, 22 topics, and 92 subtopics that cover the wide breadth of Pathology Informatics. The four major divisions include: (1 Information Fundamentals, (2 Information Systems, (3 Workflow and Process, and (4 Governance and Management. A detailed, comprehensive reading list for the curriculum is presented in the Appendix to the manuscript and contains 570 total readings (current as of March 2012. Discussion: The adoption of a formal, core curriculum in a Pathology Informatics fellowship has significant impacts on both fellowship training and the general field of Pathology Informatics itself. For a fellowship, a core curriculum defines a basic, common scope of knowledge that the fellowship expects all of its graduates will know, while at the same time enhancing and broadening the traditional fellowship experience of research and operational rotations. For the field of Pathology Informatics itself, a core curriculum defines to the outside world

  3. Characteristic clinical and pathologic features for preoperative diagnosed groove pancreatitis

    OpenAIRE

    Kim, Joo Dong; Han, Young Seok; Choi, Dong Lak

    2011-01-01

    Purpose Groove pancreatitis is a rare specific form of chronic pancreatitis that extends into the anatomical area between the pancreatic head, the duodenum, and the common bile duct, which are referred to as the groove areas. We present the diagnostic modalities, pathological features and clinical outcomes of a series of symptomatic patients with groove pancreatitis who underwent pancreaticoduodenectomy. Methods Six patients undergoing pancreaticoduodenectomy between May 2006 and May 2009 due...

  4. Perinatal pathology: the role of the clinical pathological dialogue in problem solving

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    Gavino Faa

    2014-06-01

    Full Text Available Pathologists and clinicians come together and exchange views, they instil in one another doubts, they break down barriers. Asphyxia, respiratory distress, sepsis, multi-organ failure (MOF, cerebral ischemia and neuroprotection, necrotizing enteritis, renal and biliary pathology (including congenital nephrotic syndrome, injury caused by drugs, cardiac decompensation, placental pathology, neonatal issues in mothers with tumor: these are the topics debated, in the true sense of the word, by perinatologists and pathologists. In some pathologies (e.g. MOF the pathophysiology is surprisingly the same in the neonate and the adult.  Different disciplines deal for example with immunohistochemistry and metabolomics with the processing of thousands of data in search of something that cannot be found with the classic criteria of anamnesis, objective examination, laboratory tests and imaging. Big data and information science promise to change the world. To come to grips with the extreme biological complexity of our organism and each of our organs, the completeness of enormous amounts of data is of extraordinary value if assessed holistically with the “omic” disciplines. Thus we have the possibility of understanding our extraordinary interindividual variability. The new technologies and their application do not diminish the role of physicians: on the contrary, they represent a formidable instrument for extending their diagnostic potential and make possible 5-P medicine: personalized, prospective, predictive, preventive, participatory.  Proceedings of the International Course on Perinatal Pathology (part of the 10th International Workshop on Neonatology · October 22nd-25th, 2014 · Cagliari (Italy · October 25th, 2014 · The role of the clinical pathological dialogue in problem solving Guest Editors: Gavino Faa, Vassilios Fanos, Peter Van Eyken

  5. The clinical pathologic research of invasive pituitary adenomas

    International Nuclear Information System (INIS)

    Objective: To study the pathological morphologic characteristics of invasive pituitary tumor and the affect of vascularization to the tumor's invasion. Methods: One hundred and thirty cases of pituitary adenoma patients were divided into two groups, including invasive pituitary adenomas and non-invasive pituitary adenomas, and the clinical data of two groups were analysed and compared. Results : The difference was statistically significant between the invasive group and the non-invasive group in the incidence rate of pathological morphologic characteristics such as high nuclear cytoplasmic ratio, cell pleomorphism, nuclear atypia and nucleoli appearance (P<0.05); there were nuclear atypia and nucleolus margination in the invasive group through electron microscopy. And there was statistical significant difference in rate of MVD expression which was higher in the invasive group than that of noninvasive group (P<0.05). Conclusion: The pathological morphologic characteristics of pituitary tumor and the high expression of MVD are significantly reference valuable in tumor aggression diagnosis, which provides valuable indicators for early clinical diagnosis of tumor invasion. (authors)

  6. Clinical, tomographic and pathological consistency in lung cancer

    International Nuclear Information System (INIS)

    An observational, descriptive and cross-sectional study was carried out in 55 patients admitted to the Internal Medicine Service of 'Conrado Benitez Garcia' University Oncology Hospital in Santiago de Cuba with clinical diagnosis of lung cancer, from December 2008 to November 2009, to characterize them according to variables of interest for research. Among the main results were predominance of male sex, age group between 60-69 years, smoking habit, and chronic bronchitis as past medical history, and acute bronchopneumonia as clinical form, lung infiltrative peripheral image as tomographic finding and adenocarcinoma in stages IIIa and IIIb as tissue confirmation, among others. There was an excellent consistency among clinical, imagenological and pathological findings.(author)

  7. Neuropathy of nitroimidazole radiosensitizers: clinical and pathological description

    International Nuclear Information System (INIS)

    The dose limiting toxicity of the nitroimidazole radiosensitizers is peripherial neuropathy. Improved pharmacology of newer drugs has eliminated the encephalopathy. Peripheral neuropathies are predominently mild to moderate paresthesias of both hands and feet. Subjective changes occur with or without minimal objective changes on neurologic exam. All of the neuropathies occurred within 30 days of the last drug dose and are of varible duration. Sural nerve biopsies from patients indicate progressive axonal degeneration affecting both large and small caliber myelinated fibers. Axonal damage appears to be more severe in the distal portion of the nerves. More data are needed for correlation of clinical and pathological changes

  8. A STUDY OF OVARIAN TUMOURS : CLINICAL AND PATHOLOGICAL CORRELATION

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    Uma Devi

    2015-10-01

    Full Text Available OBJECTIVE: To study incidence age distribution of benign and malignant ovarian tu mours in general population. METHODS AND MATERIAL : To study 120 patients with ovarian tumours in Govt . general hospital during June 2003 and June 2005. RESULTS: Clinical and pathological evaluation of all ovarian tumours was done and incidence, age distrib ution of various benign and malignant ovarian neoplasms were tabulated and compared with other studies. CONCLUSIONS: Most common ovarian tumours are benign tumours and serous cystadenoma is the commonest benign tumour and S erous cystadeno carcinoma is the most common malignant tumour.

  9. Clinical-pathologic correlations in vascular cognitive impairment and dementia.

    Science.gov (United States)

    Flanagan, Margaret; Larson, Eric B; Latimer, Caitlin S; Cholerton, Brenna; Crane, Paul K; Montine, Kathleen S; White, Lon R; Keene, C Dirk; Montine, Thomas J

    2016-05-01

    The most common causes of cognitive impairment and dementia are Alzheimer's disease (AD) and vascular brain injury (VBI), either independently, in combination, or in conjunction with other neurodegenerative disorders. The contribution of VBI to cognitive impairment and dementia, particularly in the context of AD pathology, has been examined extensively yet remains difficult to characterize due to conflicting results. Describing the relative contribution and mechanisms of VBI in dementia is important because of the profound impact of dementia on individuals, caregivers, families, and society, particularly the stability of health care systems with the rapidly increasing age of our population. Here we discuss relationships between pathologic processes of VBI and clinical expression of dementia, specific subtypes of VBI including microvascular brain injury, and what is currently known regarding contributions of VBI to the development and pathogenesis of the dementia syndrome. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. PMID:26319420

  10. Clinical and Pathological Roles of Ro/SSA Autoantibody System

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    Ryusuke Yoshimi

    2012-01-01

    Full Text Available Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE and Sjögren's syndrome (SS. Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.

  11. Clinical, mammographic, and pathologic concordance in breast cancer

    International Nuclear Information System (INIS)

    An observational descriptive and cross-sectional study was carried out in 100 patients with breast cancer, who attended the Breast Care Department at 'Conrado Benitez' Teaching Oncology Hospital in Santiago de Cuba from August 2009 to July 2010, to characterize them according to imaging, pathological, clinical, and general variables. Percentage as summary measure to statically validate the results and Kappa index to determine diagnostic concordance were used. Women between 40-49 years with history of fibrocystic breast disease and palpable lesions, as well as lump in the right breast, upper outer quadrant and periphery of the breast, tumor greater than one centimeter in diameter and infiltrating ductal carcinoma in the stages III-b and IV prevailed in the case material.(author)

  12. Talk in Interaction in the Speech-Language Pathology Clinic: Bringing Theory to Practice through Discourse

    Science.gov (United States)

    Leaby, Margaret M.; Walsh, Irene P.

    2008-01-01

    The importance of learning about and applying clinical discourse analysis to enhance the talk in interaction in the speech-language pathology clinic is discussed. The benefits of analyzing clinical discourse to explicate therapy dynamics are described.

  13. Retroperitoneal and pelvic hemangiopericytomas: A clinical, radiologic, pathologic correlative study

    International Nuclear Information System (INIS)

    The hemangiopericytoma (HP) is an aggressive neoplasm consisting of proliferation of endothelial-lined capillaries with intact reticulum sheaths surrounded by the pericyte. Approximately a fifth of these lesions occur in the retroperitoneum. This is the first large clinical, radiologic, pathologic study of retroperitoneal HP (17 cases). Significant clinical findings included a palpable mass (64%) and hypoglycemia in one. Approximately 40% were located in the true anatomic pelvis or near the cecum along the pelvic psoas muscle. Radiographically, a mass may be seen on plain film, IVP, or barium studies which might displace, compress, or rarely invade an adjacent organ. Most significant was the angiographic findings of an extremely vascular tumor with extensive collateralization, hypertrophy of vessels, and venous engorgement. On CT, HP appeared as a large, bulky well-defined enhancing tumor occasionally with areas of low density in a swirled or marbled pattern. Although by no means diagnostic, HP can be considered when a hypervascular retroperitoneal tumor is encountered on angiography or a large, enhancing mass with several low-density areas is recognized on CT

  14. Serrated polyposis syndrome: Molecular, pathological and clinical aspects

    Institute of Scientific and Technical Information of China (English)

    Carla Guarinos; Cristina Sánchez-Fortún; María Rodríguez-Soler; Cristina Alenda; Artemio Payá; Rodrigo Jover

    2012-01-01

    Hyperplastic polyps have traditionally been considered not to have malignant potential.New pathological classification of serrated polyps and recent discoveries about the serrated pathway of carcinogenesis have revolutionized the concepts and revitalized the research in this area.Until recently,it has been thought that most colorectal cancers arise from conventional adenomas via the traditional tumor suppressor pathway initiated by a mutation of the APC gene,but it has been found that this pathway accounts for only approximately 70%-80%of colorectal cancer (CRC) cases.The majority of the remaining colorectal cancer cases follow an alternative pathway leading to CpG island methylator phenotype carcinoma with BRAF mutation and with or without microsatellite instability.The mechanism of carcinomas arising from this alternative pathway seems to begin with an activating mutation of the BRAF oncogene.Serrated polyposis syndrome is a relatively rare condition characterized by multiple and/or large serrated polyps of the colon.Clinical characteristics,etiology and relationship of serrated polyposis syndrome to CRC have not been clarified yet.Patients with this syndrome show a high risk of CRC and both sporadic and hereditary cases have been described.Clinical criteria have been used for diagnosis and frequent colonoscopy surveillance should be performed in order to prevent colorectal cancer.In this review,we try to gather new insights into the molecular pathogenesis of serrated polyps in order to understand their possible clinical implications and to make an approach to the management of this syndrome.

  15. Cardiovascular pathology in veterans of Great Patriotic War and aged patients: spectrum and clinical pattern

    Directory of Open Access Journals (Sweden)

    Denisova Т.Р.

    2011-09-01

    Full Text Available Cardiovascular pathology spectrum and dynamics in veterans of Great Patriotic War and aged patients of Volga agricultural and industrial region were studied. Clinical signs and course of cardiovascular pathology in aged patients were determined. A «dissolution» phenomenon of chronic cardiovascular pathology was revealed in patients aged over 100 years

  16. Lymphoplasmacytic sclerosing cholangitis: assessment of clinical, CT, and pathological findings

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, S., E-mail: shigekimiyo@luck.ocn.ne.j [Department of Technical Radiology, Nagoya University School of Health Sciences, Nagoya (Japan); Nagasaka, T. [Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya (Japan); Suzuki, K.; Satake, H.; Ota, T.; Naganawa, S. [Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya (Japan)

    2009-11-15

    Aim: To assess the clinical, computed tomography (CT), and pathological findings in patients with lymphoplasmacytic sclerosing cholangitis. Materials and methods: Fifteen consecutive patients (four women and 11 men, mean age 71 years) with lymphoplasmacytic sclerosing cholangitis and without the characteristic features of underlying disorders causing benign biliary strictures were retrospectively recruited. Two radiologists evaluated multiphase contrast-enhanced CT images acquired with 0.5 or 1-mm collimation. One pathologist performed all histological examinations, including IgG4 immunostaining. Results: The intrahepatic biliary ducts showed dilatation in all 15 patients, but only seven presented with jaundice. Although laboratory data were not available in all patients, serum gammaglobulin and IgG levels were elevated in five of six patients and six of eight patients, respectively. Anti-nuclear antibody was detected in three of six patients. The involved biliary ducts showed the following CT findings: involvement of the hilar biliary duct (14/15), a mean wall thickness of 4.9 mm, a smooth margin (10/15), a narrow but visible lumen (6/15), hyper-attenuation during the late arterial phase (9/15), homogeneous hyper-attenuation during the delayed phase (11/11), and no vascular invasion (14/15). Abnormal findings in the pancreas and urinary tract were detected in eight of 15 patients. In 13 patients with adequate specimens, moderate to severe lymphoplasmacytic infiltration associated with dense fibrosis was observed. Infiltration of IgG4-positive plasma cells was moderate or severe in nine patients and minimal or absent in four patients. Conclusion: Lymphoplasmacytic sclerosing cholangitis exhibits relatively characteristic clinical and CT findings, although they are not sufficiently specific for differentiation from other biliary diseases.

  17. Lymphoplasmacytic sclerosing cholangitis: assessment of clinical, CT, and pathological findings

    International Nuclear Information System (INIS)

    Aim: To assess the clinical, computed tomography (CT), and pathological findings in patients with lymphoplasmacytic sclerosing cholangitis. Materials and methods: Fifteen consecutive patients (four women and 11 men, mean age 71 years) with lymphoplasmacytic sclerosing cholangitis and without the characteristic features of underlying disorders causing benign biliary strictures were retrospectively recruited. Two radiologists evaluated multiphase contrast-enhanced CT images acquired with 0.5 or 1-mm collimation. One pathologist performed all histological examinations, including IgG4 immunostaining. Results: The intrahepatic biliary ducts showed dilatation in all 15 patients, but only seven presented with jaundice. Although laboratory data were not available in all patients, serum gammaglobulin and IgG levels were elevated in five of six patients and six of eight patients, respectively. Anti-nuclear antibody was detected in three of six patients. The involved biliary ducts showed the following CT findings: involvement of the hilar biliary duct (14/15), a mean wall thickness of 4.9 mm, a smooth margin (10/15), a narrow but visible lumen (6/15), hyper-attenuation during the late arterial phase (9/15), homogeneous hyper-attenuation during the delayed phase (11/11), and no vascular invasion (14/15). Abnormal findings in the pancreas and urinary tract were detected in eight of 15 patients. In 13 patients with adequate specimens, moderate to severe lymphoplasmacytic infiltration associated with dense fibrosis was observed. Infiltration of IgG4-positive plasma cells was moderate or severe in nine patients and minimal or absent in four patients. Conclusion: Lymphoplasmacytic sclerosing cholangitis exhibits relatively characteristic clinical and CT findings, although they are not sufficiently specific for differentiation from other biliary diseases.

  18. Clinical and pathological studies of borderline gastrointestinal stromal tumors

    Institute of Scientific and Technical Information of China (English)

    SHI Yuan; TAN Yun-shan; ZHU Xiong-zeng; HOU Ying-yong; LU Shao-hua; ZHOU Yang; XU Jian-fang; JI Yuan; HOU Jun; XU Chen; LIU Ya-lan

    2010-01-01

    Background Borderline gastrointestinal stromal tumors (GISTs) are intermediate tumors between benign and malignant variants; however, the clinical and pathological features of borderline GISTs remain poorly defined. This study aimed to characterize GISTs and to identify a set of borderline criteria for practical use.Methods Medical records and specimens of 840 patients from 12 hospitals were retrospectively examined. Totally 485 and 76 patients with any of the parameters predictive of either malignant or benign tumors were excluded. The Kaplan-Meier method was used to calculate disease-free survival and overall survival rates.Results Among the remaining 279 borderline GIST patients, 223 were followed up for 1 to 31.48 years. Two patients developed local recurrence, and both were cured by subsequent operations alone. The 5-year disease-free survival and overall survival rates were 99% and 100%, respectively. Morphologically, borderline GISTs typically exhibited moderate cellularity, and subsets of them also showed moderate atypia, low mitotic activities, or large tumor size. According to the National Institutes of Health (NIH) consensus criteria, the risk levels of the 279 GISTs were classified to be very low to high. However, the disease-free survival rates were not significantly different among these risk groups (P=0.681).Conclusions The proposed borderline GIST criteria in the current study may complement the existing NIH criteria,based primarily on tumor size and mitotic count, in the evaluation of the biological behaviors of GISTs. Since a subset of borderline GISTs with high risk level showed favorable outcome, the introduction of the borderline GIST system may avoid overdiagnosis and over therapy.

  19. Clinical and pathologic diagnosis and different diagnosis of syphilis cervical lymphadenitis

    OpenAIRE

    Yuan, Yufen; Zhang, Xinlian; Xu, Nan; Wang, Libo; Li, Fangchao; Zhang, Ping; Miao, Lanfang; Yang, Haijun

    2015-01-01

    Purpose: To study the clinical pathologic characteristics and differential diagnosis of syphilitic cervical lymphadenitis, and to improve the rate of its diagnosis and treatment. Methods: Retrospectively analyzed the clinical history, Trepone pallidum-ELISA (TP-ELISA), rapid plasma regain test (RPR) and routine pathological examination of the patient diagnosed as syphilis lymphadenitis. And review related literatures. Results: The main clinical presentation was multiple palpable cervical lymp...

  20. A retrospective analysis of clinical and pathological features of thyroid carcinoma

    Institute of Scientific and Technical Information of China (English)

    李晓静

    2014-01-01

    Objective To analyze the clinical and pathological characteristics of thyroid carcinoma in patients from Qilu Hospital of Shandong University in last 7 years,and to explore the changes in disease spectrum.Methods Records of 772 patients with thyroid carcinoma,who underwent thyroidectomy and pathological examination,were

  1. Heterogeneous Pathology of Melasma and Its Clinical Implications

    OpenAIRE

    Soon-Hyo Kwon; Young-Ji Hwang; Soo-Keun Lee; Kyoung-Chan Park

    2016-01-01

    Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the skin, with frequent facial involvement. Its histologic manifestations are evident in the epidermis, extracellular matrix, and dermis. In addition to epidermal pigmentation, pathologic findings of melasma include extracellular matrix abnormality, especially solar elastosis. The disrupted basement membrane has been described in melasma with variable incidences. In the dermis, an increase in vascularity and an in...

  2. Pneumococcal meningitis: clinical-pathological correlations (MeninGene-Path).

    Science.gov (United States)

    Engelen-Lee, Joo-Yeon; Brouwer, Matthijs C; Aronica, Eleonora; van de Beek, Diederik

    2016-01-01

    Pneumococcal meningitis is associated with substantial mortality and morbidity. We systematically assessed brain histopathology of 31 patients who died of pneumococcal meningitis from a nationwide study (median age 67 years; 21 (67 %) were male) using a pathology score including inflammation and vascular damage. Of the 27 patients with known time from the admission to death, 14 patients died within 7 days of admission and 13 after 7 days of admission. Eleven of 25 (44 %) patients had been treated with adjunctive dexamethasone therapy. Observed pathological processes were inflammation of medium-large arteries in 30 brains (97 %), cerebral haemorrhage in 24 (77 %), cerebritis in 24 (77 %), thrombosis in 21 (68 %), infarction in 19 (61 %) and ventriculitis in 19 (of 28 cases, 68 %). Inflammation of medium-large arteries led to obstruction of the vascular lumen in 14 (of 31 cases, 45 %). Vascular inflammation was associated with infarction and thrombosis of brain parenchymal vessels. Hippocampal dentate gyrus apoptosis between patients treated with and without dexamethasone was similar (p = 0.66); however, dexamethasone treated patients had higher total pathology score than non-dexamethasone treated patients (p = 0.003). Our study shows that vascular damage is key in the process of brain damage in pneumococcal meningitis. Data and material of this study will be made open-access for translational research in pneumococcal meningitis (MeninGene-Path). PMID:27001057

  3. Strengthening the Role of Ocular Pathology in Clinical Thinking Training Targeting for House Staff

    Institute of Scientific and Technical Information of China (English)

    Yungang Ding; Wenxin Zhang; Xiaohui Liu; Jianxian Lin; Jianliang Zheng; Yongping Li

    2011-01-01

    Ocular pathology serves as one vital branch subject of histopathology, and also as a basic ocular science analysing the pathogenesis of eye disease,the regular pattern of disease progress,and ocular morphology,tissue metabolism and functional changes noted during the onset of ocular diseases.The underlying purpose lies in revealing and investigating the mechanism of such diseases and the nature of lesions,providing essential theoretical evidence to diagnosis and treatment of eye diseases.ocular pathology acts as a bridge connecting basic and clinical medical science1.Clinical ophthalmologists,especially junior house staff,should attach importance to ocular pathology,understand,be familiar with,and master basic knowledge in ocular pathological subject to cultivate sound clinical thinking and analytical ability and to improve comprehensive diagnosis and treatment efficacy in clinical setting.

  4. 42 CFR 414.510 - Laboratory date of service for clinical laboratory and pathology specimens.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Laboratory date of service for clinical laboratory... AND OTHER HEALTH SERVICES Payment for New Clinical Diagnostic Laboratory Tests § 414.510 Laboratory date of service for clinical laboratory and pathology specimens. The date of service for either...

  5. Familial dementia lacking specific pathological features presenting with clinical features of corticobasal degeneration

    OpenAIRE

    Brown, J.; Lantos, P.; Rossor, M

    1998-01-01

    A family is described in which one member presented with symptoms and signs suggestive of corticobasal degeneration and a sibling presented with features of a frontal lobe dementia. Their mother developed a presenile dementia and movement disorder. At postmortem examination the member with clinical corticobasal degeneration had non-specific pathological features. Therefore, the clinical features of corticobasal degeneration can occur with non-specific pathological changes. Within ...

  6. Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration

    OpenAIRE

    Rohrer, J D.; Lashley, T.; Schott, J. M.; Warren, J. E.; MEAD, S.; Isaacs, A M; Beck, J; Hardy, J.; R. SILVA; Warrington, E; Troakes, C.; Al-Sarraj, S; King, A.; Borroni, B; Clarkson, M. J.

    2011-01-01

    Relating clinical symptoms to neuroanatomical profiles of brain damage and ultimately to tissue pathology is a key challenge in the field of neurodegenerative disease and particularly relevant to the heterogeneous disorders that comprise the frontotemporal lobar degeneration spectrum. Here we present a retrospective analysis of clinical, neuropsychological and neuroimaging (volumetric and voxel-based morphometric) features in a pathologically ascertained cohort of 95 cases of frontotemporal l...

  7. Distinct Clinic-Pathological Features of Early Differentiated-Type Gastric Cancers after Helicobacter pylori Eradication

    OpenAIRE

    Noriyuki Horiguchi; Tomomitsu Tahara; Tomohiko Kawamura; Masaaki Okubo; Takamitsu Ishizuka; Yoshihito Nakagawa; Mitsuo Nagasaka; Tomoyuki Shibata; Naoki Ohmiya

    2016-01-01

    Background. Gastric cancer is discovered even after successful eradication of H. pylori. We investigated clinic pathological features of early gastric cancers after H. pylori eradication. Methods. 51 early gastric cancers (EGCs) from 44 patients diagnosed after successful H. pylori eradication were included as eradication group. The clinic-pathological features were compared with that of 131 EGCs from 120 patients who did not have a history of H. pylori eradication (control group). Results. C...

  8. Pneumococcal meningitis: Clinical-pathological correlations (meningene-path)

    OpenAIRE

    Engelen-Lee, Joo-Yeon; Brouwer, Matthijs C.; Aronica, Eleonora; de Beek, Diederik van

    2016-01-01

    Pneumococcal meningitis is associated with substantial mortality and morbidity. We systematically assessed brain histopathology of 31 patients who died of pneumococcal meningitis from a nationwide study (median age 67 years; 21 (67 %) were male) using a pathology score including inflammation and vascular damage. Of the 27 patients with known time from the admission to death, 14 patients died within 7 days of admission and 13 after 7 days of admission. Eleven of 25 (44 %) patients had been tre...

  9. [Rheumatic activity and clinico-pathologic dissociation. Clinical and pathologic parameters in rheumatic heart disease].

    Science.gov (United States)

    Bernal, E; Maas, M; Osornio, A; Reyes, P A

    1987-01-01

    We studied atrial appendages and valvular apparatus from patients undergoing cardiac surgery for rheumatic heart disease, looking for active histologic lesions. After reviewing 673 specimens (1980-1985) we studied two groups: 31 cases with Aschoff nodules or ill-differentiated histopathological lesions, and 31 cases, without tissular inflammatory abnormalities. In the former we found 8 cases with suspected clinical activity in a 3 months period before surgery, in the latter only 2 cases had similar findings. The Jones criteria are not useful for recognizing rheumatic activity among patients with chronic rheumatic heart disease, there is no clinical-histopathological correlations and it is possible that chronic inflammation occurs at the heart as an organ-limited condition. PMID:2952088

  10. Clinical and pathological features in 49 elderly patients with meningiomas

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: As aging in elderly people, their brain tissue has degeneration and brain atrophy of different severity, and the volume of cranial cavity is relatively enlarged, it has greater compensatory ability to the space occupying lesion, and it is difficult to detect the meningioma because it grows to expand slowly, the tumor locates in non-functional region, and there are atypical symptoms and deficiency of localization signs.OBJECTIVE: To investigate the clinicopathologic features of senile meningiomas.DESIGN: A retrospective analysis.SETTING: Affiliated Hospital of Hebei University.PARTICIPANTS: Forty-nine elderly patients with meningioma were selected from the Department of Neurosurgery, Affiliated Hospital of Hebei University from May 1999 to March 2005, including 15 males and 34 females, 60 - 74 years of age, and they were all diagnosed by CT and MRI.METHODS: The sites of tumors were identified by CT and MRI examinations in all the patients. The tumors were partially or totally resected according to their own conditions. The types of the resected tumor were pathologically observed. The conditions of postoperative recovery were observed after 1, 3 and 6 months, and without new neurological dysfunction or complication was considered as good outcome.MAIN OUTCOME MEASURES: ① Sites and pathological types of the tumor; ② Postoperative outcomes and complications.RESULTS: All the 49 patients were involved in the analysis of results. ① The tumors had wide distributions with a main location in brain convexity. Among the 49 cases of meningioma, there were 25 cases of fibrocystic type, 12 cases of meningothelial type, 6 cases of psammomatous type, 4 cases of angiomatous type and 2 cases of microcystic type. ② Among the 49 patients, 35 had good outcome, 8 had self-care ability, 4 required care by others, 2 (4.1%) died postoperatively. No long-term complication related to the operation was observed during the follow-up postoperatively.CONCLUSION: Meningioma has

  11. Using pathology-specific laboratory profiles in Clinical Pathology to reduce inappropriate test requesting: two completed audit cycles

    Directory of Open Access Journals (Sweden)

    Baricchi Roberto

    2012-07-01

    Full Text Available Abstract Background Systematic reviews have shown that, although well prepared, the Consensus Guidelines have failed to change clinical practice. In the healthcare district of Castelnovo né Monti (Reggio Emilia, Italy, it became necessary for the GPs and Clinical Pathologists to work together to jointly define laboratory profiles. Methods Observational study with two cycles of retrospective audit on test request forms, in a primary care setting. Objectives of the study were to develop pathology-specific laboratory profiles and to increase the number of provisional diagnoses on laboratory test request forms. A Multiprofessional Multidisciplinary Inter-hospital Work Team developed pathology-specific laboratory profiles for more effective test requesting. After 8 training sessions that used a combined strategy with multifaceted interventions, the 23 General Practitioners (GPs in the trial district (Castelnovo nè Monti tested the profiles; the 21 GPs in the Puianello district were the control group; all GPs in both districts participated in the trial. All laboratory tests for both healthcare districts are performed at the Laboratory located in the trial district. A baseline and a 1-year audit were performed in both districts on the GPs’ request forms. Results Seven pathology-specific laboratory profiles for outpatients were developed. In the year after the first audit cycle: 1 the number of tests requested in the trial district was distinctly lower than that in the previous year, with a decrease of about 5% (p  Conclusions The first audit cycle showed a significant decrease in the number of tests ordered only in the trial district. The combined strategy used in this study improved the prescriptive compliance of most of the GPs involved. The presence of the clinical pathologist is seen as an added value.

  12. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis

    OpenAIRE

    Lucchinetti, C.F.; Gavrilova, R. H.; Metz, I.; Parisi, J.E.; Scheithauer, B. W.; Weigand, S.; Thomsen, K.; Mandrekar, J.; Altintas, A.; Erickson, B. J.; König, F.; C. Giannini; Lassmann, H; Linbo, L.; Pittock, S.J.

    2008-01-01

    Atypical imaging features of multiple sclerosis lesions include size >2 cm, mass effect, oedema and/or ring enhancement. This constellation is often referred to as ‘tumefactive multiple sclerosis’. Previous series emphasize their unifocal and clinically isolated nature, however, evolution of these lesions is not well defined. Biopsy may be required for diagnosis. We describe clinical and radiographic features in 168 patients with biopsy confirmed CNS inflammatory demyelinating disease (IDD). ...

  13. Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease

    DEFF Research Database (Denmark)

    Callesen, Mette Buhl; Hansen, Kim Vang; Gjedde, Albert;

    2013-01-01

    -making, and altered striatal dopaminergic neurotransmission. Using [(11)C]raclopride with positron emission tomography, we assessed dopaminergic neurotransmission during Iowa Gambling Task performance. Here we present data from a single patient with PD and concomitant PG. We noted a marked decrease in [(11)C......Dopaminergic medication for motor symptoms in Parkinson's disease (PD) recently has been linked with impulse control disorders, including pathological gambling (PG), which affects up to 8% of patients. PG often is considered a behavioral addiction associated with disinhibition, risky decision......]raclopride binding in the left ventral striatum upon gambling, indicating a gambling-induced dopamine release. The results imply that PG in PD is associated with a high dose of dopaminergic medication, pronounced motor symptomatology, young age at disease onset, high propensity for sensation seeking, and risky...

  14. Heterogeneous Pathology of Melasma and Its Clinical Implications.

    Science.gov (United States)

    Kwon, Soon-Hyo; Hwang, Young-Ji; Lee, Soo-Keun; Park, Kyoung-Chan

    2016-01-01

    Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the skin, with frequent facial involvement. Its histologic manifestations are evident in the epidermis, extracellular matrix, and dermis. In addition to epidermal pigmentation, pathologic findings of melasma include extracellular matrix abnormality, especially solar elastosis. The disrupted basement membrane has been described in melasma with variable incidences. In the dermis, an increase in vascularity and an increase in the number of mast cells were observed, indicating that dermal factors have critical roles in the pathogenesis of melasma, despite the fact that melasma is characterized by epidermal hyperpigmentation. This review discusses such histologic characteristics of melasma, with consideration to their implications for melasma treatment. PMID:27240341

  15. Heterogeneous Pathology of Melasma and Its Clinical Implications

    Directory of Open Access Journals (Sweden)

    Soon-Hyo Kwon

    2016-05-01

    Full Text Available Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the skin, with frequent facial involvement. Its histologic manifestations are evident in the epidermis, extracellular matrix, and dermis. In addition to epidermal pigmentation, pathologic findings of melasma include extracellular matrix abnormality, especially solar elastosis. The disrupted basement membrane has been described in melasma with variable incidences. In the dermis, an increase in vascularity and an increase in the number of mast cells were observed, indicating that dermal factors have critical roles in the pathogenesis of melasma, despite the fact that melasma is characterized by epidermal hyperpigmentation. This review discusses such histologic characteristics of melasma, with consideration to their implications for melasma treatment.

  16. Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

    Energy Technology Data Exchange (ETDEWEB)

    Li, Qinghai; Li, Jinning; Zhang, Lan; Chen, Ying; Zhang, Minming [Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009 (China); Yan, Fuhua, E-mail: zemylife@163.com [Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 (China)

    2014-05-15

    Objective: To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD). Methods: Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal–Wallis H test was conducted to compare ADC values and pathology type. Results: Renal ADC values correlated negatively with pathology scores (r = −0.633, P < 0.001). The ADC values among the four groups (mild, moderate, severe impairment, and controls) were significantly different (F = 19.512, P < 0.001). However, when patients were stratified by pathology type, no significant differences were found in ADC values among these groups (χ{sup 2} = 9.929, P = 0.270). Further multiple linear regression analysis showed that only the pathology score and ADC values were related (t = −4.586, P = 0.000). Conclusions: DWI has clinical potential in assessing the severity of renal pathology in CKD and shows promise as a non-invasive and effective technique to guide therapy and follow-up.

  17. Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

    International Nuclear Information System (INIS)

    Objective: To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD). Methods: Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal–Wallis H test was conducted to compare ADC values and pathology type. Results: Renal ADC values correlated negatively with pathology scores (r = −0.633, P < 0.001). The ADC values among the four groups (mild, moderate, severe impairment, and controls) were significantly different (F = 19.512, P < 0.001). However, when patients were stratified by pathology type, no significant differences were found in ADC values among these groups (χ2 = 9.929, P = 0.270). Further multiple linear regression analysis showed that only the pathology score and ADC values were related (t = −4.586, P = 0.000). Conclusions: DWI has clinical potential in assessing the severity of renal pathology in CKD and shows promise as a non-invasive and effective technique to guide therapy and follow-up

  18. Clinical and pathological characterization of palpebral malignant tumors

    International Nuclear Information System (INIS)

    A descriptive, retrospective study of patients with histopathologic diagnosis of basal cell carcinoma, squamous cell and adenocarcinoma of sebaceous glands, assisted in the service of oculoplasty the Cuban Institute of Ophthalmology January 2005 to December 2010. It was included 109 patients; we analyzed age, sex, skin color, clinical symptoms, anatomic location, degree of cell differentiation and annual basis

  19. CLINICAL CASE OF PERSISTENT ATRIAL FLUTTER IN PATIENT WITH COMORBID PATHOLOGY

    OpenAIRE

    Gavrilyuk, O.; Boeva, Y.; Anyasi, I.; Maltseva, M.; Volkov, D.

    2013-01-01

    Clinical case of persistent atrial flutter in combination with comorbid pathology is presented. Clinical diagnosis, choice of optimal interventional and drug therapy are discussed. Catheter ablation was considered as the optimal method for radical treatment of the atrial flutter. A modification of drug therapy is required according to the condition of the patient after the catheter ablation.

  20. Impact of Placement Type on the Development of Clinical Competency in Speech-Language Pathology Students

    Science.gov (United States)

    Sheepway, Lyndal; Lincoln, Michelle; McAllister, Sue

    2014-01-01

    Background: Speech-language pathology students gain experience and clinical competency through clinical education placements. However, currently little empirical information exists regarding how competency develops. Existing research about the effectiveness of placement types and models in developing competency is generally descriptive and based…

  1. Experiences of Student Speech-Language Pathology Clinicians in the Initial Clinical Practicum: A Phenomenological Study

    Science.gov (United States)

    Nelson, Lori A.

    2011-01-01

    Speech-language pathology literature is limited in describing the clinical practicum process from the student perspective. Much of the supervision literature in this field focuses on quantitative research and/or the point of view of the supervisor. Understanding the student experience serves to enhance the quality of clinical supervision. Of…

  2. Gender-related clinical and neurocognitive differences in individuals seeking treatment for pathological gambling

    DEFF Research Database (Denmark)

    Grant, Jon E; Chamberlain, Samuel R; Schreiber, Liana R N;

    2012-01-01

    Understanding variations in disease presentation in men and women is clinically important as differences may reflect biological and sociocultural factors and have implications for selecting appropriate prevention and treatment strategies. The aim of this study was to investigate clinical and cogn...... cognitive differences in treatment-seeking people with pathological gambling as a function of gender....

  3. Spontaneous Pathology and Routine Clinical Pathology Parameters in Aging Beagle Dogs: A Comparison With Adolescent and Young Adults.

    Science.gov (United States)

    Barnes, J; Cotton, P; Robinson, S; Jacobsen, M

    2016-03-01

    AstraZeneca ran a bespoke study to generate age-matched clinical pathology and histopathology data from a cohort of Beagle dogs aged between 25 and 37 months to support the use of these older animals in routine preclinical toxicology studies. As the upper age range of Beagle dogs routinely used in toxicology studies does not normally exceed 24 months, there is an absence of appropriate age-matched historical control data. The generation of such data was crucial to understand whether age-related differences in spontaneous findings might confound the interpretation of toxicology study data. While the majority of the histopathology findings in all the older dogs occurred at a similar prevalence as those expected in young adult dogs (<24 months), a number of differences were observed in the thymus (involution), bone marrow (increased adiposity), testes (degenerative changes), and lung (fibrosis, pigment and alveolar hyperplasia) that could be misinterpreted as a test article effect. Minor differences in some clinical pathology values (hemoglobin, alkaline phosphatase, absolute reticulocytes) were of a small magnitude and considered unlikely to affect the interpretation of study data. PMID:26553522

  4. [Sudeck disease--pathology, clinical aspects and therapy].

    Science.gov (United States)

    Schulz, R H; Buch, K

    1998-06-01

    In our opinion the etiology of Sudeck's disease (acute reflex bone atrophy) plays a decisive role in therapeutic planning. The therapy is based on clinical and radiological findings. Physiotherapy addresses the symptom complex of pain, hyperemia, edema formation, and limitations of movement which act in a vicious circle and its intensity is modified according to the prevailing clinical and possibly also radiological findings. A strict coupling of the therapy to a classification according to stage is not recommended. Pharmacological therapy is merely a supporting element and focuses on the sympathetic overexcitability. The best therapy for Sudeck's disease is prophylaxis. Interventions collected under the general term early functional mobilization are, especially after surgical measures, a major factor in the avoidance of neurovegetative dysregulation in the sense of sympathetic reflex dystrophy. PMID:9738286

  5. Existing data sources for clinical epidemiology: the Danish National Pathology Registry and Data Bank

    Directory of Open Access Journals (Sweden)

    Rune Erichsen

    2010-03-01

    Full Text Available Rune Erichsen1, Timothy L Lash1, Stephen J Hamilton-Dutoit2, Beth Bjerregaard3, Mogens Vyberg2,4, Lars Pedersen11Department of Clinical Epidemiology, 2Institute of Pathology, 4Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark; 3Department of Pathology and the Pathology Data Bank, Herlev University Hospital, Herlev, DenmarkAbstract: Diagnostic histological and cytological specimens are routinely stored in pathology department archives. These biobanks are a valuable research resource for many diseases, particularly if they can be linked to high quality population-based health registries, allowing large retrospective epidemiological studies to be carried out. Such studies are of significant importance, for example in the search for novel prognostic and predictive biomarkers in the era of personalized medicine. Denmark has a wealth of highly-regarded population-based registries that are ideally suited to conduct this type of epidemiological research. We describe two recent additions to these databases: the Danish National Pathology Registry (DNPR and its underlying national online registration database, the Danish Pathology Data Bank (DPDB. The DNPR and the DPDB contain detailed nationwide records of all pathology specimens analyzed in Denmark since 1997, and an incomplete but nonetheless valuable record of specimens from some pathology departments dating back to the 1970s. The data are of high quality and completeness and are sufficient to allow precise and efficient localization of the specimens. We describe the relatively uncomplicated procedures required to use these pathology databases in clinical research and to gain access to the archived specimens.Keywords: cohort profile, epidemiology, paraffin blocks, pathology

  6. Epidemiological, Clinical and Pathological Features of Primary Cardiac Hemangiosarcoma in Dogs: A Review of 51 Cases

    OpenAIRE

    Yamamoto, Shinya; HOSHI, Katsuichiro; HIRAKAWA, Atsushi; CHIMURA, Syuuichi; Kobayashi, Masayuki; Machida, Noboru

    2013-01-01

    ABSTRACT In the study presented here, we aimed to describe the epidemiological, clinical and pathological findings of 51 canine cases with histologically-verified diagnoses of primary cardiac hemangiosarcoma (HSA). The medical data for each dog, including signalment, presenting complaints, physical examination findings, results of various diagnostic testing performed and method of treatment, were checked. In addition, all 51 cases were re-examined pathologically. The tumor occurred most frequ...

  7. Matrix metalloproteinases and their inhibitors in cardiovascular pathologies: current knowledge and clinical potential

    OpenAIRE

    Johnson, Jason

    2014-01-01

    Jason Lee Johnson Laboratory of Cardiovascular Pathology, School of Clinical Sciences, University of Bristol, Bristol, UK Abstract: Matrix metalloproteinases (MMPs) constitute a family of endopeptidases that harbor matrix-degrading potential, but also modulate the proliferation, migration, and apoptosis of resident blood-vessel cells and recruited inflammatory cells. Accordingly, they are proposed to play a major regulatory role in numerous cardiovascular pathologies, including restenosis, a...

  8. Clinical pathology and retinal vascular structure in the Bardet-Biedl syndrome.

    OpenAIRE

    Bek, T; Rosenberg, T

    1995-01-01

    A comparative study of clinical pathology and retinal vascular structure is described as studied by vascular casting in an eye of a patient with the Bardet-Biedl syndrome. At the time of examination the eye had been almost blind for at least 4 years. The histopathological examination showed a largely uniform loss of the outer retinal layers. The gross pathological examination of the cast ocular fundus showed three distinct zones, an inner zone inside the temporal vascular arcades where retina...

  9. Clinical-pathological-angiographic correlations following transluminal atherectomy

    International Nuclear Information System (INIS)

    Following percutaneous atherectomy, arterial and catheter diameter relationships were correlated with angiographic and ankle-arm index results. There was a greater amount of tissue removed, improved luminal reconstitution, and ankle-arm index in lesions where the catheter and arterial diameters were equal or within 0.5 mm. Excluding lesions requiring angioplasty, 77% of our lesions had less than 30% residual stenosis; including lesions requiring concomitant angioplasty, the initial overall patency was 93%, with a 1-year patency rate of 92.5%. This study indicates that adequate matching of the atherectomy catheter diameter to the arterial diameter is necessary to optimize tissue removal and clinical results

  10. The feasibility of using natural language processing to extract clinical information from breast pathology reports

    OpenAIRE

    Buckley, Julliette M.; Coopey, Suzanne B.; John Sharko; Fernanda Polubriaginof; Brian Drohan; Belli, Ahmet K.; Kim, Elizabeth M. H.; Garber, Judy E.; Smith, Barbara L; Gadd, Michele A.; Specht, Michelle C.; Roche, Constance A.; Gudewicz, Thomas M.; Hughes, Kevin S.

    2012-01-01

    Objective: The opportunity to integrate clinical decision support systems into clinical practice is limited due to the lack of structured, machine readable data in the current format of the electronic health record. Natural language processing has been designed to convert free text into machine readable data. The aim of the current study was to ascertain the feasibility of using natural language processing to extract clinical information from >76,000 breast pathology reports. Approach and Pro...

  11. Membranous nephropathy in the cat: a clinical and pathological study.

    Science.gov (United States)

    Nash, A S; Wright, N G; Spencer, A J; Thompson, H; Fisher, E W

    1979-07-28

    A series of 13 cases of feline membranous nephropathy is presented. Two groups were distinguished clinically; eight cats had the nephrotic syndrome and five others were in renal failure but not nephrotic. The definitive diagnosis was based on histological, immunofluorescence and ultrastructural examinations of renal tissue obtained at renal biopsy or necropsy. Glomerular lesions were classified according to the degree of glomerular change into three distinct groups; mild, moderately severe and advanced. A relationship was established between the mild and moderately severe groups and cats with the nephrotic syndrome, and the advanced group and cats in renal failure. Diuretic therapy was satisfactory in initial control of oedema in the nephrotic cases. Monitoring of previously nephrotic cats for up to three years indicated that the disease is progressive, although in some cases it is sufficiently slow for a cat to live a relatively normal life without continuing treatment. The prognosis for cats presented in renal failure is hopeless. PMID:552741

  12. Distinct Clinic-Pathological Features of Early Differentiated-Type Gastric Cancers after Helicobacter pylori Eradication.

    Science.gov (United States)

    Horiguchi, Noriyuki; Tahara, Tomomitsu; Kawamura, Tomohiko; Okubo, Masaaki; Ishizuka, Takamitsu; Nakagawa, Yoshihito; Nagasaka, Mitsuo; Shibata, Tomoyuki; Ohmiya, Naoki

    2016-01-01

    Background. Gastric cancer is discovered even after successful eradication of H. pylori. We investigated clinic pathological features of early gastric cancers after H. pylori eradication. Methods. 51 early gastric cancers (EGCs) from 44 patients diagnosed after successful H. pylori eradication were included as eradication group. The clinic-pathological features were compared with that of 131 EGCs from 120 patients who did not have a history of H. pylori eradication (control group). Results. Compared with control group, clinic-pathological features of eradication group were characterized as depressed (p EGC after H. pylori eradication are depressed, reddish appearances, which should be treated as a caution because histological diagnosis of cancerous tissue is sometimes difficult by endoscopic biopsy. PMID:27212944

  13. The role of tau in the pathological process and clinical expression of Huntington's disease

    DEFF Research Database (Denmark)

    Vuono, Romina; Winder-Rhodes, Sophie; de Silva, Rohan;

    2015-01-01

    progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clinical features, especially the dementia, are not fully understood. Recently the microtubule associated protein tau, MAPT, which is associated with several neurodegenerative disorders, has been implicated...... report not only on the tau pathology in the Huntington's disease brain but also the association between genetic variation in tau gene and the clinical expression and progression of the disease. We found extensive pathological inclusions containing abnormally phosphorylated tau protein that co...... in Huntington's disease. We explored this association in more detail at the neuropathological, genetic and clinical level. We first investigated tau pathology by looking for the presence of hyperphosphorylated tau aggregates, co-localization of tau with mutant HTT and its oligomeric intermediates in...

  14. Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.

    Science.gov (United States)

    Kim, Chong Jai; Romero, Roberto; Chaemsaithong, Piya; Chaiyasit, Noppadol; Yoon, Bo Hyun; Kim, Yeon Mee

    2015-10-01

    Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and chorionic vasculitis and represent a host response (maternal or fetal) to a chemotactic gradient in the amniotic cavity. While acute chorioamnionitis is evidence of a maternal host response, funisitis and chorionic vasculitis represent fetal inflammatory responses. Intraamniotic infection generally has been considered to be the cause of acute chorioamnionitis and funisitis; however, recent evidence indicates that "sterile" intraamniotic inflammation, which occurs in the absence of demonstrable microorganisms induced by "danger signals," is frequently associated with these lesions. In the context of intraamniotic infection, chemokines (such as interleukin-8 and granulocyte chemotactic protein) establish a gradient that favors the migration of neutrophils from the maternal or fetal circulation into the chorioamniotic membranes or umbilical cord, respectively. Danger signals that are released during the course of cellular stress or cell death can also induce the release of neutrophil chemokines. The prevalence of chorioamnionitis is a function of gestational age at birth, and present in 3-5% of term placentas and in 94% of placentas delivered at 21-24 weeks of gestation. The frequency is higher in patients with spontaneous labor, preterm labor, clinical chorioamnionitis (preterm or term), or ruptured membranes. Funisitis and chorionic vasculitis are the hallmarks of the fetal inflammatory response syndrome, a condition characterized by an elevation in the fetal plasma concentration of interleukin-6, and associated with the impending onset of preterm labor, a higher rate of neonatal morbidity (after adjustment for gestational age), and multiorgan fetal involvement. This syndrome is the counterpart of the systemic inflammatory response syndrome in adults: a risk factor for short- and long

  15. Mucosal malignant melanoma - a clinical, oncological, pathological and genetic survey.

    Science.gov (United States)

    Mikkelsen, Lauge H; Larsen, Ann-Cathrine; von Buchwald, Christian; Drzewiecki, Krzysztof T; Prause, Jan U; Heegaard, Steffen

    2016-06-01

    Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma and conjunctival melanoma, which are very rare in Black people. The symptoms are not tumour-specific and are related to the organ system affected, and the disease is most often diagnosed at an advanced clinical stage. The diagnosis of a primary tumour is difficult, and metastatic cutaneous melanoma and choroidal melanoma must be excluded. Mutations in KIT are frequently found, while BRAF and NRAS mutations are rarely found - except in conjunctival melanomas that carry BRAF mutations. Mutations in the TERT promotor region are also found in mucosal melanomas. Complete surgical resection with free margins is the treatment of choice. The prognosis is poor, with the 5-year survival rate ranging from 0% (gastric melanoma) to 80% (conjunctival melanoma). PMID:27004972

  16. Occupational Lung Disease: Clinical-Pathological-Radiological Correlation

    International Nuclear Information System (INIS)

    People are exposed to hundreds of substances daily, some of which may induce pulmonary injury. Occupational Lung Disease diagnosis requires 4 elements: Exposure to the harmful agent, adequate latency between exposure and beginning of the symptoms, syndrome with post-exposure abnormalities, and exclusion of other conditions which may otherwise explain signs and symptoms. Several occupational lung disease classifications based on structural or functional injury, type of agent, or both have been proposed. Generally, 5 groups are considered: Pneumoconiosis, hypersensitivity pneumonitis, toxic fumes exposure, asthma, and occupational lung infections. Conventional radiographs and in specific situations, CT, are crucial elements for the diagnosis of Occupational Lung Disease. In the patient with respiratory symptoms and altered imaging studies, the possibility of Occupational Lung Disease should be considered. Radiologist should be familiar the variety of substances that cause these entities and their radiological features. In this article Occupational Lung diseases are reviewed, including diagnostic criteria, classification, physiopathology, clinical and radiological manifestations as well as their corresponding histopathological features.

  17. [Syphilis. Part 1: Introduction, pathology and clinical aspects].

    Science.gov (United States)

    Gross, G; Flaig, B; Rode, S

    2013-10-01

    In Germany more than 3,500 people become infected with syphilis annually. As elsewhere in Western Europe there is a low level endemicity with a concentration among population subgroups with high rates of partner exchange, such as men who have sex with other men. In Germany after initially reduced numbers of cases, the incidence rate has increased after the turn of the millennium. In 2011 the incidence reached 4.5 cases per 100,000 inhabitants, which is the highest incidence since the introduction of the Infection Protection Act of 2001. Syphilis, like other sexually transmitted infections and diseases with its manifold clinical manifestations and complex diagnostics, is a large global problem for public health systems. The recent resurgence of syphilis presents a challenge for all physicians but particularly for dermatologists and venereologists because the skin and adjacent mucous membranes are initially affected. Rapid diagnosis, differential diagnosis, consequent treatment and monitoring can cure the disease. Prevention of misdiagnosis is essential otherwise severe, sometimes fatal cardiovascular complications, neurosyphilis and transfer to unborn and newborn children can occur. The synergy of syphilis and sexually transmitted human immunodeficiency virus (HIV) is of special importance. Syphilis together with genital herpes and other sexually transmitted genital and oral ulcers is an important pacemaker for HIV. PMID:24150827

  18. Clinical correlates of grey matter pathology in multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Horakova Dana

    2012-03-01

    Full Text Available Abstract Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white matter. However, this view has lately been subject to numerous changes, as new evidence of anatomical and histological changes as well as of molecular targets within the grey matter has arisen. This advance was driven mainly by novel imaging techniques, however, these have not yet been implemented in routine clinical practice. The changes in the grey matter are related to physical and cognitive disability seen in individuals with multiple sclerosis. Furthermore, damage to several grey matter structures can be associated with impairment of specific functions. Therefore, we conclude that grey matter damage - global and regional - has the potential to become a marker of disease activity, complementary to the currently used magnetic resonance markers (global brain atrophy and T2 hyperintense lesions. Furthermore, it may improve the prediction of the future disease course and response to therapy in individual patients and may also become a reliable additional surrogate marker of treatment effect.

  19. Fatal familial insomnia: clinical and pathologic heterogeneity in genetic half brothers.

    Science.gov (United States)

    Johnson, M D; Vnencak-Jones, C L; McLean, M J

    1998-12-01

    We describe clinical and pathologic features of a patient with fatal familial insomnia (FFI) whose prion (PrP) genotype is D178N coupled with methionine at codon 129 on his mutant allele and valine at codon 129 on his normal allele. A cousin (genetic half brother) with identical PrP genotypes exhibited strikingly different clinical and pathologic changes. Comparison of these cousins shows the phenotypic heterogeneity of FFI and suggests that the phenotypic expression of D178N is influenced by multiple factors. PMID:9855529

  20. [A clinical and pathological study of diffuse axonal injury].

    Science.gov (United States)

    Nakazawa, S; Kobayashi, S; Yokota, H; Shimura, T

    1989-03-01

    There is increasing evidence from human and experimental studies that the most important factor governing the outcome in head injury is the severity of diffuse axonal injuries. The authors have experienced 18 cases of severe diffuse axonal injury which showed post-traumatic coma for more than 24 hours and CT findings resembling those of shearing injuries of the cerebral white matter such as have been presented by Zimmerman et al. (1978). The consciousness levels on admission were 6 or less on the Glasgow Coma Scale and all cases were shown clinically to have primary brain stem injury. The main type of head trauma resulted from road traffic accidents (83%). Skull fractures were found in only 5 cases (28%). These findings suggested that acceleration/deceleration injury produce in the patients severe diffuse axonal injury. Initial ICP was below 20 mmHg in 11 cases out of 13 (85%). Parenchymal small hemorrhagic lesions of initial CT were basal ganglia (7 cases), corpus callosum (4 cases), pons (4 cases), midbrain (3 cases) and thalamus (2 cases). Extraparenchymal hemorrhagic lesions included intraventricular hemorrhage (6 cases) and subarachnoid hemorrhage (6 cases). Two autopsied cases of severe diffuse axonal injury (acute case and chronic case) showed remarkable congestion and edema in the deep part of the frontal white matter. Microscopic examination revealed marked axonal degeneration including axonal retraction ball in the corpus callosum, in the internal capsule and in the white matter of the brain stem. Glasgow Outcome Scale of the 18 patients at 3 months after the trauma made us concerned that no patients indicated good recovery or even only moderate disability.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2770962

  1. Pathogenesis, clinical features and pathology of chronic arsenicosis

    Directory of Open Access Journals (Sweden)

    Sengupta Sujit

    2008-01-01

    Full Text Available Arsenicosis is a multisystem disorder, with virtually no system spared from its vicious claw; though its predominant manifestations are linked to cutaneous involvement. Cutaneous effects take the form of pigmentary changes, hyperkeratosis, and skin cancers (Bowen′s disease, squamous cell carcinoma, and basal cell epithelioma. Peripheral vascular disease (blackfoot disease, hypertension, ischemic heart disease, noncirrhotic portal hypertension, hepatomegaly, peripheral neuropathy, respiratory and renal involvement, bad obstetrical outcome, hematological disturbances, and diabetes mellitus are among the other clinical features linked to arsenic toxicity. The effects are mediated principally by the trivalent form of arsenic (arsenite, which by its ability to bind with sulfhydryl groups present in various essential compounds leads to inactivation and derangement of body function. Though the toxicities are mostly linked to the trivalent state, arsenic is consumed mainly in its pentavalent form (arsenate, and reduction of arsenate to arsenite is mediated through glutathione. Body attempts to detoxify the agent via repeated oxidative methylation and reduction reaction, leading to the generation of methylated metabolites, which are excreted in the urine. Understandably the detoxification/bio-inactivation process is not a complete defense against the vicious metalloid, and it can cause chromosomal aberration, impairment of DNA repair process, alteration in the activity of tumor suppressor gene, etc., leading to genotoxicity and carcinogenicity. Arsenic causes apoptosis via free radical generation, and the cutaneous toxicity is linked to its effect on various cytokines (e.g., IL-8, TGF-β, TNF-α, GM-CSF, growth factors, and transcription factors. Increased expression of cytokeratins, keratin-16 (marker for hyperproliferation and keratin-8 and -18 (marker for less differentiated epithelial cells, can be related to the histopathological findings of

  2. Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma

    Directory of Open Access Journals (Sweden)

    Andi Sadayandi Ramesh

    2014-01-01

    Full Text Available Background: Olfactory groove schwannomas (OGS are rare anterior cranial fossa base tumors with only 41 cases reported in literature. Olfactory ensheathing cell schwannoma (OECS has similar clinico-radiological features as OGS, but a different cell of origin. In recent years, there is growing interest in OECS as more cases are being reported. Aims: The objective was to study the clinico-radiological features of OGS and define the histological differentiation from OECS. Materials and Methods: We retrospectively analyzed clinical, radiological, surgical and histopathological picture of all cases of OGS managed in our institute. Immuno histochemical studies were performed in these tumors for differentiating from OECS. A comprehensive review of articles published until date describing the operative treatment was done. Results: All three cases had presented with seizures, two had anosmia and papilledema. Gross-total resection was achieved in all our patients. One patient expired in the postoperative period due to septicemia. Positive expression to newer immuno histochemical biomarker CD57 (Leu7, with negative staining to smooth muscle α-actin (SMA was helpful in confirming the diagnosis of OGS and differentiating it from OECS in all our cases. Conclusions: OECS, though rare has to be differentiated from OGS using immuno histochemistry. Gross-total resection of OGS with preservation of olfactory function is often possible and curative. Although these tumors are commonly treated with microsurgical skull base approaches, an endoscopic endonasal approach can be considered in some cases, with repair using mucoperiosteal pedicled flap to prevent cerebrospinal fluid leak.

  3. Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy.

    Science.gov (United States)

    Liu, Xinhong; Wu, Huamin; Gong, Jian; Wang, Tao; Yan, Chuanzhu

    2016-05-01

    The aim of the present study was to report on a family with pathologically and genetically diagnosed autosomal dominant inherited centronuclear myopathy (CNM). In addition, this study aimed to investigate the clinical, pathological and molecular genetic characteristics of the disease. This pedigree was traced back three generations, four patients underwent neurological examination, two patients underwent muscle biopsy, and eight family members were subjected to dynamin 2 (DNM2) gene mutation analysis. DNM2 mutations were detected in seven family members, of which four patients exhibited DNM2 mutation‑specific clinical and pathological features. Lower extremity weakness was the predominant symptom of these patients, however, proximal and distal lower extremity involvement was inconsistent. All patients exhibited marked systematic muscle atrophy and various degrees of facial muscle involvement. The patients presented the typical pathological changes of CNM, and their muscle tissues were heavily replaced by adipose tissue, with clustered distribution of muscle fibers as another notable feature. DNM2‑CNM patients of this pedigree exhibited heterogeneous clinical and pathological features, providing a basis for further molecular genetic analysis. PMID:27035234

  4. The feasibility of using natural language processing to extract clinical information from breast pathology reports

    Directory of Open Access Journals (Sweden)

    Julliette M Buckley

    2012-01-01

    Full Text Available Objective: The opportunity to integrate clinical decision support systems into clinical practice is limited due to the lack of structured, machine readable data in the current format of the electronic health record. Natural language processing has been designed to convert free text into machine readable data. The aim of the current study was to ascertain the feasibility of using natural language processing to extract clinical information from >76,000 breast pathology reports. Approach and Procedure: Breast pathology reports from three institutions were analyzed using natural language processing software (Clearforest, Waltham, MA to extract information on a variety of pathologic diagnoses of interest. Data tables were created from the extracted information according to date of surgery, side of surgery, and medical record number. The variety of ways in which each diagnosis could be represented was recorded, as a means of demonstrating the complexity of machine interpretation of free text. Results: There was widespread variation in how pathologists reported common pathologic diagnoses. We report, for example, 124 ways of saying invasive ductal carcinoma and 95 ways of saying invasive lobular carcinoma. There were >4000 ways of saying invasive ductal carcinoma was not present. Natural language processor sensitivity and specificity were 99.1% and 96.5% when compared to expert human coders. Conclusion: We have demonstrated how a large body of free text medical information such as seen in breast pathology reports, can be converted to a machine readable format using natural language processing, and described the inherent complexities of the task.

  5. Clinical application of FDG PET for pathological response of breast cancer after neo-adjuvant chemotherapy

    International Nuclear Information System (INIS)

    The purpose of this study was to assess the clinical usefulness of FDG PET in predicting the pathological response in breast cancer after neoadjuvant chemotherapy. 33 patients with newly diagnosed, locally advanced breast cancer had PET scans before and after chemotherapy to assess tumor response, and then pathology was confirmed after surgery. FDG PET for assessing tumor response was done by measuring peak SUV (pSUV) and then calculating reduction rate (RR). RR was stratified into RR complete response (rrCR) at >88% reduction, RR partial response (rrPR) at RR between 56∼87%, and no response (rrNR) in reductions <55%. Clinical assessment was done with physical exams, U/S, and CT. Histopathological response were classified into pathological no response(pNR), pathological partial response (pPR) and pathological complete response (pCR). 15% (5 of 33) patients had pCR, 85% (28 of 33) had pPR. Using a 88% reduction in SUV as a threshold value for differentiation between pCR from pPR, PET scans correctly differentiated pCR in 3 patients out of 5. When using a cut off value of 55% reduction rate, PET scans correctly differentiated pPR in 19 patients out of 21, and for pNR, the PET scans correctly differentiated only 2 patients out of 7. Diagnostic accuracy of PET for pathologic response was 25 out of 33 cases (75.8%). The diagnostic accuracy of clinical assessment was 25 of 33 cases (72.7%). This study suggests that pSUV reduction rate can be a useful tool when predicting the pathological response of primary breast cancers after neo-adjuvant chemotherapy

  6. Distinct Clinic-Pathological Features of Early Differentiated-Type Gastric Cancers after Helicobacter pylori Eradication

    Directory of Open Access Journals (Sweden)

    Noriyuki Horiguchi

    2016-01-01

    Full Text Available Background. Gastric cancer is discovered even after successful eradication of H. pylori. We investigated clinic pathological features of early gastric cancers after H. pylori eradication. Methods. 51 early gastric cancers (EGCs from 44 patients diagnosed after successful H. pylori eradication were included as eradication group. The clinic-pathological features were compared with that of 131 EGCs from 120 patients who did not have a history of H. pylori eradication (control group. Results. Compared with control group, clinic-pathological features of eradication group were characterized as depressed (p<0.0001, reddish (p=0.0001, and smaller (p=0.0095 lesions, which was also confirmed in the comparison of six metachronous lesions diagnosed after initial ESD and subsequent successful H. pylori eradication. Prevalence of both SM2 (submucosal invasion greater than 500 μm and unexpected SM2 cases tended to be higher in eradication group (p=0.077, 0.0867, resp.. Prevalence of inconclusive diagnosis of gastric cancer during pretreatment biopsy was also higher in the same group (26.0% versus 1.6%, p<0.0001. Conclusions. Informative clinic pathological features of EGC after H. pylori eradication are depressed, reddish appearances, which should be treated as a caution because histological diagnosis of cancerous tissue is sometimes difficult by endoscopic biopsy.

  7. Distinct Clinic-Pathological Features of Early Differentiated-Type Gastric Cancers after Helicobacter pylori Eradication

    Science.gov (United States)

    Horiguchi, Noriyuki; Tahara, Tomomitsu; Kawamura, Tomohiko; Okubo, Masaaki; Ishizuka, Takamitsu; Nakagawa, Yoshihito; Nagasaka, Mitsuo; Shibata, Tomoyuki; Ohmiya, Naoki

    2016-01-01

    Background. Gastric cancer is discovered even after successful eradication of H. pylori. We investigated clinic pathological features of early gastric cancers after H. pylori eradication. Methods. 51 early gastric cancers (EGCs) from 44 patients diagnosed after successful H. pylori eradication were included as eradication group. The clinic-pathological features were compared with that of 131 EGCs from 120 patients who did not have a history of H. pylori eradication (control group). Results. Compared with control group, clinic-pathological features of eradication group were characterized as depressed (p < 0.0001), reddish (p = 0.0001), and smaller (p = 0.0095) lesions, which was also confirmed in the comparison of six metachronous lesions diagnosed after initial ESD and subsequent successful H. pylori eradication. Prevalence of both SM2 (submucosal invasion greater than 500 μm) and unexpected SM2 cases tended to be higher in eradication group (p = 0.077, 0.0867, resp.). Prevalence of inconclusive diagnosis of gastric cancer during pretreatment biopsy was also higher in the same group (26.0% versus 1.6%, p < 0.0001). Conclusions. Informative clinic pathological features of EGC after H. pylori eradication are depressed, reddish appearances, which should be treated as a caution because histological diagnosis of cancerous tissue is sometimes difficult by endoscopic biopsy. PMID:27212944

  8. Adnexal torsion: clinical, radiological and pathological characteristics in a tertiary care centre in Southern India

    OpenAIRE

    Swapna Mohan; Mariam Thomas; Jayasree Raman

    2014-01-01

    Background: Adnexal torsion accounts for 2.7% of gynecological emergencies. Early diagnosis can help prevent irreversible damage to ovary. Objective of this study was to analyze the clinical, radiological and pathological characteristics of surgically proven cases of ovarian torsion. Methods: Observational study was carried out from January 2006 to June 2014. Medical records of 38 cases of adnexal torsion were selected and analyzed retrospectively for age, parity, risk factors, clinical pr...

  9. An autopsy study of combined pulmonary fibrosis and emphysema: correlations among clinical, radiological, and pathological features

    OpenAIRE

    Inomata, Minoru; Ikushima, Soichiro; Awano, Nobuyasu; Kondoh, Keisuke; Satake, Kohta; Masuo, Masahiro; Kusunoki, Yuji; Moriya, Atsuko; Kamiya, Hiroyuki; Ando, Tsunehiro; Yanagawa, Noriyo; Kumasaka, Toshio; Ogura, Takashi; Sakai, Fumikazu; Azuma, Arata

    2014-01-01

    Background Clinical evaluation to differentiate the characteristic features of pulmonary fibrosis and emphysema is often difficult in patients with combined pulmonary fibrosis and emphysema (CPFE), but diagnosis of pulmonary fibrosis is important for evaluating treatment options and the risk of acute exacerbation of interstitial pneumonia of such patients. As far as we know, it is the first report describing a correlation among clinical, radiological, and whole-lung pathological features in a...

  10. Dopaminergic and clinical correlates of pathological gambling in Parkinson's disease: A case report

    Directory of Open Access Journals (Sweden)

    Mette Buhl Callesen

    2013-07-01

    Full Text Available Dopaminergic medication for motor symptoms in Parkinson’s disease recently has been linked with impulse control disorders, including pathological gambling, which affects up to 8% of patients. Pathological gambling often is considered a behavioral addiction associated with disinhibition, risky decision-making, and altered striatal dopaminergic neurotransmission. Using [11C]raclopride with positron emission tomography, we assessed dopaminergic neurotransmission during Iowa Gambling Task performance. Here we present data from a single patient with Parkinson’s disease and concomitant pathological gambling. We noted a marked decrease in [11C]raclopride binding in the left ventral striatum upon gambling, indicating a gambling-induced dopamine release. The results imply that pathological gambling in Parkinson’s disease is associated with a high dose of dopaminergic medication, pronounced motor symptomatology, young age at disease onset, high propensity for sensation seeking, and risky decision-making. Overall, the findings are consistent with the hypothesis of medication-related pathological gambling in Parkinson’s disease and underscore the importance of taking clinical variables, such as age and personality, into account when patients with Parkinson’s disease are medicated, to reduce the risk of pathological gambling.

  11. The boundaries of cellular pathology: how pathologists see their clinical role.

    Science.gov (United States)

    Jenkins, David; Philips, Zoë; Grisaffiî, Kate; Whynes, David K

    2002-03-01

    There has been much recent public attention on the effects of the practices of cellular pathology on patients and their relatives. It is important to establish clearly pathologists' views about their professional relationships to clinicians and patients. A national postal questionnaire survey was performed to investigate how cellular pathologists perceive their role in clinical practice and whether there are important differences between different groups of pathologists. Responses were received from 773 pathologists, of whom 167 were trainees. On the basis of responses to 25 attitude statements, it appears that the profession shares a core belief that pathologists are clinicians rather than scientists and sees diagnosis as its main clinical responsibility. However, the role that each pathologist feels clear about differs significantly between pathologists, with a stronger consensus over function, responsibility, and professional image than on the clinical practice of pathology, job satisfaction, and the impact of technological change. Academic activities are a minority interest, although academic pathologists express better job satisfaction and more radical views of professional practice. Young trainees are more likely to work in teaching hospitals, to be female, to have trained outside the UK, and to have had experience in other specialties. They have, however, a more restricted view of the clinical role of pathology than accredited pathologists. Most cellular pathologists see themselves as clinicians with a special role in diagnosis, but how this is interpreted and the extent to which pathologists involve themselves in clinical decision-making is inconsistent. This professional dilemma should be addressed by research to obtain more systematic knowledge of the clinical impact of cellular pathology and especially the ill-defined links between diagnosis and clinical decision-making. PMID:11857501

  12. Clinical and pathological study on 10 cases of cerebral lobe hemorrhage related with cerebral amyloid angiopathy

    Directory of Open Access Journals (Sweden)

    Xiao-qi LI

    2015-07-01

    Full Text Available Objective To summarize the clinical data and pathological features of 10 cases of cerebral lobar hemorrhage related with cerebral amyloid angiopathy (CAA diagnosed pathologically, thereby to improve the knowledge and diagnosis of the disease. Methods The clinical data of 10 cases of cerebral lobar hemorrhage related with CAA, collected in the General Hospital of Shenyang Command from 1983 up to now, were retrospectively analyzed, and the clinical and neuropathological features of these cases were summarized. Results Of the 10 patients, 2 suffered from single lobar hemorrhage and 8 multiple lobar hemorrhage, all of them were confirmed pathologically to have ruptured into the subarachnoid space. Pathological examination revealed microaneurysm in 2 cases, "double barrel" change in 4 cases, multiple arteriolar clusters in 5 cases, obliterative onion-liked intima change in 4 cases, and fibrinoid necrosis of vessel wall in 7 cases. In addition, neurofibrillary tangles were found in 8 cases, and senile plaque was observed in 5 cases. Conclusions Cerebral lobar hemorrhage related with CAA is mainly located in the parietal, temporal and occipital lobes, readily breaking into the subarachnoid space, and it is often multiple and recurrent. The CAA associated microvasculopathy was found frequently in the autopsy sample of CAA related cerebral lobar hemorrhage, and it may contribute to the pathogenesis of cerebral hemorrhage. DOI: 10.11855/j.issn.0577-7402.2015.07.04

  13. Diseases of the inner ear. A clinical, radiologic, and pathologic atlas

    International Nuclear Information System (INIS)

    This book is a comprehensive atlas of the clinical conditions that commonly involve the inner ear and lateral skull base. Each disorder or disease is meticulously and beautifully illustrated, with accompanying informative text. An important feature of the book is that no disorder is described from a single point of view. Instead, the clinical features are linked with both radiologic and pathologic findings to provide an all-encompassing picture of the condition in question. This is feasible because the book is the result of years of intense collaborative teamwork between departments at the University of Toronto and the Tehran University of Medical Sciences, and includes many clinical and pathologic images that could only be acquired in major referral units. It is anticipated that this atlas will assist greatly in improving collaboration between clinicians and surgeons in the diagnostic, therapeutic, and surgical management of disorders in this challenging area. (orig.)

  14. Heterogeneity of the clinical manifestations and pathology features in C3 glomerulopathy

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    Jin-quan WANG

    2015-01-01

    Full Text Available C3 glomerulopathy is a kind of glomerular diseases mediated by abnormal activation of alternative complement pathway. As diversity and multiplicity of pathogenic mechanism, heterogeneity exists in the clinical manifestation and pathological features of C3 glomerulopathy. The clinical manifestation of the disease may be shown as abnormality in urine, hypertension, hematuria, nephrotic syndrome, nephritic syndrome, renal insufficiency, etc. Membranoproliferative glomerulonephritis, mesangial proliferation, crescent formation, focal segmental necrosis, diffuse hyperplasia and exudative lesions, etc may be found in renal biopsies. Also, the prognosis of C3 glomerulopathy is not uniform. The clinical manifestations and pathological features of C3 glomerulopathy were reviewed in the present paper. DOI: 10.11855/j.issn.0577-7402.2014.12.15

  15. Prognostic significance of clinical and pathological stages on locally advanced rectal carcinoma after neoadjuvant chemoradiotherapy

    International Nuclear Information System (INIS)

    To investigate prognostic significance of clinical and pathological stages in patients with locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy (neo-CRT) and total mesorectal excision. 210 patients with locally advanced rectal carcinoma (cT3-4 or cN+) treated with neo-CRT followed by total mesorectal excision. Treatment outcomes were compared according to clinical and pathological stage. Overall survival (OS), disease free survival (DFS) among patients with different clinical stage and pathological stage after neo-CRT. The median follow-up time was 47 months (range, 14–98 months). Clinical T stage was associated with 5 year OS (p = 0.042) and 5 year DFS (p = 0.014) while clinical N stage was not associated with 5 year OS (p = 0.440), 5 year DFS (p = 0.711). Pathological T stage was associate with 5 year OS (p = 0.001) and 5 year DFS (p = 0.046); and N stage was associated with 5 year OS (p = 0.001), 5 year DFS (p = 0.002). The pathological stage was further classified into three groups: ypT0–2N0 in 91 patients (43.3 %), ypT3–4N0 in 69 patients (32.9 %) and ypT0–4N+ in 50 patients (23.8 %). While pathological stage (ypT0–2 vs ypT3–4N0 vs ypT0–4N+) was associated with 5 year OS (87.9 %, 75.5 %, 56.7 %, p = 0.000), 5 year DFS (74.5 %, 77.4 %, 50.5 %, p = 0.003). Multivariate analysis showed that ypN stage was an independent prognostic factor for patients 5 year DFS. Pathological stage is strongly associated with treatment outcomes in patients with locally advanced rectal carcinoma treated with neo-CRT followed by total mesorectal excision, which may be used as guidance for further individualized treatment

  16. Associations between cardiac pathology and clinical, echocardiographic and electrocardiographic findings in dogs with chronic congestive heart failure

    DEFF Research Database (Denmark)

    Falk, Bo Torkel; Jönsson, Lennart; Olsen, Lisbeth Høier;

    2010-01-01

    The objective of this study was to correlate defined pathological features with clinical findings in dogs with naturally occurring congestive heart failure (CHF). Fifty-eight dogs with CHF were examined clinically and using echocardiography and electrocardiography. Detailed cardiac post...

  17. Clinical applications of CO2 laser resurfacing in the treatment of various pathologic skin disorders

    Science.gov (United States)

    Giler, Shamai

    1997-12-01

    CO2 laser skin resurfacing devices are widely used in cosmetic surgery for the treatment of facial rhytides, acne scars and aging skin. This technique is also useful in the treatment of various benign and premalignant or multiple pathological skin conditions and disorders originating in the epidermal, dermal and skin appendages, vascular lesions, epidermal nevi, infected wounds and ulcers, and keloids. Various surgical techniques have been developed in our clinic using laser resurfacing in the treatment of more than 2,000 patients with various skin pathologic disorders. We describe our experience with the various techniques used. The precise depth control and ablation properties combined with the hemostatic and sterilizing effects of the CO2 laser beam, reduction of the possibility of bleeding, infection and damage to healthy tissues, make the CO2 laser resurfacing techniques the treatment of choice for cosmetic surgery and treatment of benign, premalignant and multiple pathologic skin conditions.

  18. Relationship between clinical and pathologic findings in patients with chronic liver diseases

    Institute of Scientific and Technical Information of China (English)

    Lun-Gen Lu; Jun Ye; Xiong Cai; Cheng-Wei Chen; Ji-Yao Wang; Shan-Ming Wu; Jin-Shui Zhu; Xia-Qiu Zhou; Min-De Zeng; Yi-Min Mao; Ji-Qiang Li; De-Kai Qiu; Jing-Yuan Fang; Ai-Ping Cao; Mo-Bin Wan; Cheng-Zhong Li

    2003-01-01

    AIM: To explore the relationship between clinical findings of patients with chronic liver diseases and the pathologic grading and staging of liver tissues.METHODS: The inflammatory activity and fibrosis of consecutive liver biopsies from 200 patients were determined according to the diagnosis criteria of chronic hepatitis in China established in 1995. A comparative analysis was carried out for 200 patients with chronic liver diseases by comparing their clinical manifestations, serum biochemical markers with the grading and staging of liver tissues.RESULTS: It was revealed that age, index of clinical symptoms and physical signs were obviously relevant to the pathologic grading and staging of liver tissues (P<0.05). Blood platelet, red blood cells, aspartate aminotransferase (AST),N-terminal procollagen Ⅲ (PⅢ NP) were apparently correlated with the degree of inflammation. PGA (prothrombin time,GGT, apoprotein A1) index, PGAA (PGA+△2-macroglobublin)index, albumin and albumin/globulin were relevant to both inflammation and fibrosis. Hyaluronic acid (HA) was an accurate variable for the severity of hepatic inflammation and fibrosis. The combination of serum markers for fibrosis could increase the diagnostic accuracy. It was notable that viral replication markers were not relevant to the degree of inflammation and fibrosis.CONCLUSION: There is a good correlation between clinical findings and the pathologic grading and staging of liver tissues, which may give aid to the noninvasive diagnosis of liver fibrosis.

  19. Clinical and pathological analysis of acute rejection following orthotopic liver transplantation

    Institute of Scientific and Technical Information of China (English)

    MA Yi; WANG Guo-dong; HE Xiao-shun; LI Jun-liang; ZHU Xiao-feng; HU Rui-de

    2009-01-01

    Background Acute rejection is one of the most important factors for prognosis following liver transplantation. With the use of potent immunosuppressants, acute rejection does not always present typical manifestations. Moreover, other complications often occur concomitantly after liver transplantation, which makes early diagnosis of acute rejection more difficult. Acute rejection is best diagnosed by liver biopsy. Differentiation of clinical manifestations and pathological features plays an important role in achieving individualized immunosuppressive treatment and prolonging long term survival of patients given orthotopic liver transplants.Methods From January 2004 to December 2006, 516 orthotopic liver transplantations were performed at the First Affiliated Hospital, Sun Yat-sen University. For patients who suffered acute rejection, clinical manifestations, histopathological features, diagnosis and anti-rejection treatment were summarized and analyzed. Results In 86 cases (16.7%), of the 516 recipients, 106 episodes of acute rejection occurred, which included 9 with histopathological borderline changes, 36 Banff Ⅰ rejections, 48 Banff Ⅱ and 13 Banff Ⅲ. Among these, 36 were cured by adjusting the dose of immunosuppressant and 65 were reversed by methylprednisolone pulse treatment. Five were methylprednisolone resistant, 3 of whom were given OKT3 treatment and 2 underwent liver retransplantation. Conclusions Due to potent immunosuppressive agents, acute rejection following an orthotopic liver transplantation lacks typical clinical manifestations and pathological features. Acute rejection is best diagnosed by liver biopsy. Designing rational individualized immunosuppressive regimen based on clinical and pathological features of acute rejection plays an important role in prolonging long term survival of patients.

  20. Clinical and Pathological Changes in Rams Experimentally Infected with Actinobacillus seminis and Histophilus somni

    OpenAIRE

    Valéria S. Moustacas; Silva, Teane M. A.; Luciana F. Costa; Custódio A. Carvalho Júnior; Santos, Renato L.; Tatiane A. Paixão

    2014-01-01

    Infectious epididymitis is considered a major cause of economic losses for the sheep industry worldwide. This study aimed to investigate clinical and pathological changes associated with experimental infections with A. seminis and H. somni in rams. Twenty rams of age 18 to 24 months were infected by intraepididymal inoculation of A. seminis (n = 10) and H. somni (n = 10). Rams were weekly examined and biological samples were collected during six weeks. All rams inoculated with A. seminis and ...

  1. Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression

    OpenAIRE

    Sato, Katsuaki; Suda, Kenichi; Shimizu, Shigeki; Sakai, Kazuko; Mizuuchi, Hiroshi; Tomizawa, Kenji; Takemoto, Toshiki; Nishio, Kazuto; Mitsudomi, Tetsuya

    2016-01-01

    The receptor tyrosine kinase AXL is a member of the Tyro3-Axl-Mer receptor tyrosine kinase subfamily. AXL affects several cellular functions, including growth and migration. AXL aberration is reportedly a marker for poor prognosis and treatment resistance in various cancers. In this study, we analyzed clinical, pathological, and molecular features of AXL expression in lung adenocarcinomas (LADs). We examined 161 LAD specimens from patients who underwent pulmonary resections. When AXL protein ...

  2. Nomograms for the Prediction of Pathologic Stage of Clinically Localized Prostate Cancer in Korean Men

    OpenAIRE

    Song, Cheryn; Kang, Taejin; Ro, Jae Y.; Lee, Moo-Song; Kim, Choung-Soo; Ahn, Hanjong

    2005-01-01

    We analyzed the prostate cancer data of 317 Korean men with clinically localized prostate cancer who underwent radical prostatectomy at Asan Medical Center between June 1990 and November 2003 to construct nomograms predicting the pathologic stage of these tumors, and compared the outcome with preexisting nomograms. Multinomial log-linear regression was performed for the simultaneous prediction of organ-confined disease (OCD), extracapsular extension (ECE), seminal vesicle invasion (SVI) and l...

  3. Simian Varicella Virus in Pigtailed Macaques (Macaca nemestrina): Clinical, Pathologic, and Virologic Features

    OpenAIRE

    Hukkanen, Renee Rosemary; Gillen, Maggie; Grant, Richard; Liggitt, H. Denny; Kiem, Hans-Peter; Kelley, Stephen T.

    2009-01-01

    Simian varicella virus (SVV; Cercopithecine herpesvirus 9) is a naturally occurring herpesvirus of nonhuman primates. Here we present the clinical, pathologic, and virologic findings from 2 cases of SVV in adult female pigtailed macaques (Macaca nemestrina). The initial case presented with hyperthermia and a diffuse inguinal rash which spread centripetally, progressing to vesiculoulcerative dermatitis of the trunk, face, and extremities. At 96 h after presentation, the animal was anorexic and...

  4. DNA methylation Profiles in Primary Cutaneous Melanomas are Associated with Clinically Significant Pathologic Features

    OpenAIRE

    Thomas, Nancy E.; Slater, Nathaniel A.; Edmiston, Sharon N.; Zhou, Xin; Kuan, Pei-Fen; Groben, Pamela A; Carson, Craig C.; Hao, Honglin; Parrish, Eloise; Moschos, Stergios J; Berwick, Marianne; Ollila, David W.; Conway, Kathleen

    2014-01-01

    DNA methylation studies have elucidated a methylation signature distinguishing primary melanomas from benign nevi and provided new insights about genes that may be important in melanoma development. However, it is unclear whether methylation differences among primary melanomas are related to tumor pathologic features with known clinical significance. We utilized the Illumina Golden Gate Cancer Panel array to investigate the methylation profiles of 47 primary cutaneous melanomas...

  5. Clinical pathology results from cranes with experimental West Nile Virus infection

    Science.gov (United States)

    Olsen, Glenn H.

    2011-01-01

    Sandhill cranes (Grus canadensis) were vaccinated for and then challenged with West Nile virus. Resulting titers demonstrated protection in the vaccinated-challenged cranes as compared to the unvaccinated-challenged cranes. Clinical pathology results showed challenged cranes, whether vaccinated or not, had a decrease in their hematocrits and an elevation of 2.5-fold in their white blood cell counts as compared to unchallenged control sandhill cranes. No differences were apparent in the differential counts of heterophils and lymphocytes.

  6. Implementation of Epic Beaker Clinical Pathology at an academic medical center

    OpenAIRE

    Krasowski, Matthew D.; Joseph D Wilford; Wanita Howard; Susan K Dane; Scott R Davis; Karandikar, Nitin J.; Blau, John L; Bradley A Ford

    2016-01-01

    Background: Epic Beaker Clinical Pathology (CP) is a relatively new laboratory information system (LIS) operating within the Epic suite of software applications. To date, there have not been any publications describing implementation of Beaker CP. In this report, we describe our experience in implementing Beaker CP version 2012 at a state academic medical center with a go-live of August 2014 and a subsequent upgrade to Beaker version 2014 in May 2015. The implementation of Beaker CP was concu...

  7. Clinical, laboratory and pathological findings in sub-acute monensin intoxication in goats

    OpenAIRE

    Deljou, Mahdi; Aslani, Mohammad Reza; Mohri, Mehrdad; Movassaghi, Ahmad Reza; Heidarpour, Mohammad

    2014-01-01

    Toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. The present study was performed to investigate the toxic effects of monensin in goats. Seven adult goats were administered sodium monensin, 13.5 mg kg-1, daily for five consecutive days via gastric gavage. Monensin toxicity was evaluated by clinical signs, serum biochemistry and pathology. Monensin exposure caused diarrhea, tachycardia and reduction in ruminal movem...

  8. Clinical pathological evaluation and risk factors of oral cancer cases of east coast of peninsular Malaysia

    OpenAIRE

    Farini, M. S.; Azlina, A.; Rushdan, I.; Manoharan, M; Zain, R. B.; Samsudin, A. R.

    2005-01-01

    Introduction: Oral cancer is one of the common cancers m Malaysia. Tile population of east coast of Peninsular Malaysia has a different hfestyle and Malay is the predominant race. Oral cancer research in this area started since the Malaysian National Oral Cancer group was established. The am: of this study is to evaluate the clinical pathological findings and to investigate the role of tobacco smoking, alcohol consurnption and betel quid chewing as tile risk factors among oral cancer cases m ...

  9. The Role of Clinical Psychiatry in Nurturing Autonomy in Female Japanese Patients with Pathological Personality Traits

    OpenAIRE

    Uji, Masayo; ウジ, マサヨ; 宇治, 雅代

    2013-01-01

    Few studies have examined patients with pathological personality traits in terms of their competency to exercise autonomy, despite the increasing number of these individuals who visit psychiatric clinics in Japan. The purpose of this study was to assess such patients’ competencies using medical record data focusing not only on the therapeutic relationship but also on the patients’ social relationships throughout their life histories. Two patients were evaluated: one with borderline personalit...

  10. Implicit attitudes towards food and the self in sub-clinical eating disorder pathology

    OpenAIRE

    A. Anokhina

    2015-01-01

    This thesis focuses on the assessment of implicit cognition in disordered eating behaviour, and specifically on the role of implicit attitudes towards the self and food in sub-clinical levels of eating disorder (ED) pathology. Chapter I reviews key theoretical approaches to implicit cognition and an assessment of the properties of implicit attitudes. Chapter II discusses methodological approaches to implicit attitude assessment, with a focus on the Implicit Attitude Test (IAT) which was used ...

  11. The ongoing evolution of the core curriculum of a clinical fellowship in pathology informatics

    Directory of Open Access Journals (Sweden)

    Andrew M Quinn

    2014-01-01

    Full Text Available The Partners HealthCare system′s Clinical Fellowship in Pathology Informatics (Boston, MA, USA faces ongoing challenges to the delivery of its core curriculum in the forms of: (1 New classes of fellows annually with new and varying educational needs and increasingly fractured, enterprise-wide commitments; (2 taxing electronic health record (EHR and laboratory information system (LIS implementations; and (3 increasing interest in the subspecialty at the academic medical centers (AMCs in what is a large health care network. In response to these challenges, the fellowship has modified its existing didactic sessions and piloted both a network-wide pathology informatics lecture series and regular "learning laboratories". Didactic sessions, which had previously included more formal discussions of the four divisions of the core curriculum: Information fundamentals, information systems, workflow and process, and governance and management, now focus on group discussions concerning the fellows′ ongoing projects, updates on the enterprise-wide EHR and LIS implementations, and directed questions about weekly readings. Lectures are given by the informatics faculty, guest informatics faculty, current and former fellows, and information systems members in the network, and are open to all professional members of the pathology departments at the AMCs. Learning laboratories consist of small-group exercises geared toward a variety of learning styles, and are driven by both the fellows and a member of the informatics faculty. The learning laboratories have created a forum for discussing real-time and real-world pathology informatics matters, and for incorporating awareness of and timely discussions about the latest pathology informatics literature. These changes have diversified the delivery of the fellowship′s core curriculum, increased exposure of faculty, fellows and trainees to one another, and more equitably distributed teaching responsibilities among

  12. The clinic and pathologic picture in the lethal dose irradiated ewes

    International Nuclear Information System (INIS)

    The history of clinical symptoms as well as pathologic histological and morphological changes after long/lasting gamma irradiation were estimated in seven clinical healthy ewes. The animals were irradiated continually seven days with totally 6.7 Gy per ewe. Clinically recognizable symptoms of the radiation sickness were observed commencing the 4th after last dose of irradiation. Sharp increase of the body temperature, heart and respiratory frequency rate as well as apathy, anorexia, arrhythmia, dyspnoe, diarrhea, dehydration, polyuria were prevalent in clinical founding . All of the animals were death in course of seven days after last irradiated dose. The gastrointestinal radiation syndrome was typical evidence of gastrointestinal tract and the general hemorrhagic enhancing of the gamma irradiation damage effects was confirmed. (authors)

  13. Clinical and surgical-pathological staging in early non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Ioannis Koukis

    2013-12-01

    Full Text Available Staging is of the utmost importance in the evaluation of a patient with non-small cell lung cancer (NSCLC because it defines the actual extent of the disease. Accurate staging allows multidisciplinary oncology teams to plan the best surgical or medical treatment and to predict patient prognosis. Based on the recommendation of the International Association for the Study of Lung Cancer (IASLC, a tumor, node, and metastases (TNM staging system is currently used for NSCLC. Clinical staging (c-TNM is achieved via non-invasive modalities such as examination of case history, clinical assessment and radiological tests. Pathological staging (p-TNM is based on histological examination of tissue specimens obtained with the aid of invasive techniques, either non-surgical or during the intervention. This review is a critical evaluation of the roles of current pre-operative staging modalities, both invasive and non-invasive. In particular, it focuses on new techniques and their role in providing accurate confirmation of patient TNM status. It also evaluates the surgical-pathological staging modalities used to obtain the true-pathological staging for NSCLC.

  14. The role of tau in the pathological process and clinical expression of Huntington’s disease

    Science.gov (United States)

    Vuono, Romina; Winder-Rhodes, Sophie; de Silva, Rohan; Cisbani, Giulia; Drouin-Ouellet, Janelle; Spillantini, Maria G.; Cicchetti, Francesca

    2015-01-01

    Huntington’s disease is a neurodegenerative disorder caused by an abnormal CAG repeat expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct from the Huntington’s disease locus itself, have been identified as being linked to the clinical expression and progression of Huntington’s disease, the exact molecular mechanisms driving its pathogenic cascade and clinical features, especially the dementia, are not fully understood. Recently the microtubule associated protein tau, MAPT, which is associated with several neurodegenerative disorders, has been implicated in Huntington’s disease. We explored this association in more detail at the neuropathological, genetic and clinical level. We first investigated tau pathology by looking for the presence of hyperphosphorylated tau aggregates, co-localization of tau with mutant HTT and its oligomeric intermediates in post-mortem brain samples from patients with Huntington’s disease (n = 16) compared to cases with a known tauopathy and healthy controls. Next, we undertook a genotype–phenotype analysis of a large cohort of patients with Huntington’s disease (n = 960) with a particular focus on cognitive decline. We report not only on the tau pathology in the Huntington’s disease brain but also the association between genetic variation in tau gene and the clinical expression and progression of the disease. We found extensive pathological inclusions containing abnormally phosphorylated tau protein that co-localized in some instances with mutant HTT. We confirmed this related to the disease process rather than age, by showing it is also present in two patients with young-onset Huntington’s disease (26 and 40 years old at death). In addition we demonstrate that tau oligomers (suggested to be the most likely neurotoxic tau entity) are present in the Huntington’s disease brains. Finally we highlight the clinical significance of this pathology by demonstrating that the MAPT

  15. A review of standardized patients in clinical education: Implications for speech-language pathology programs.

    Science.gov (United States)

    Hill, Anne E; Davidson, Bronwyn J; Theodoros, Deborah G

    2010-06-01

    The use of standardized patients has been reported as a viable addition to traditional models of professional practice education in medicine, nursing and allied health programs. Educational programs rely on the inclusion of work-integrated learning components in order to graduate competent practitioners. Allied health programs world-wide have reported increasing difficulty in attaining sufficient traditional placements for students within the workplace. In response to this, allied health professionals are challenged to be innovative and problem-solving in the development and maintenance of clinical education placements and to consider potential alternative learning opportunities for students. Whilst there is a bank of literature describing the use of standardized patients in medicine and nursing, reports of its use in speech-language pathology clinical education are limited. Therefore, this paper aims to (1) provide a review of literature reporting on the use of standardized patients within medical and allied health professions with particular reference to use in speech-language pathology, (2) discuss methodological and practical issues involved in establishing and maintaining a standardized patient program and (3) identify future directions for research and clinical programs using standardized patients to build foundation clinical skills such as communication, interpersonal interaction and interviewing. PMID:20433345

  16. Do clinical diagnoses correlate with pathological diagnoses in cardiac transplant patients? The importance of endomyocardial biopsy

    DEFF Research Database (Denmark)

    Luk, Adriana; Metawee, Mohammed; Ahn, Eric;

    2009-01-01

    BACKGROUND: Heart transplantation remains the last treatment option for patients with end-stage cardiac disease. Such diseases include ischemic cardiomyopathy, nonischemic cardiomyopathy and other conditions such as arrhythmogenic right ventricular dysplasia, cardiac sarcoidosis and cardiac...... amyloidosis. OBJECTIVE: To review the changes that have occurred over time in the etiology of heart disease in patients requiring heart transplantation, and to compare the clinical and histological diagnoses of explanted hearts from patients with progressive cardiac disease. METHODS: The pathological findings...... of 296 surgically excised hearts over a 20-year period (January 1987 to July 2006) at one institution were examined. Patients were separated into groups based on year of heart transplantation. The tissue was examined to determine the underlying cardiac pathology leading to congestive heart failure...

  17. Comparative study of clinical, pathological and HRCT findings of primary alveolar proteinosis and silicoproteinosis

    International Nuclear Information System (INIS)

    Objective: To compare the clinical, high-resolution computed tomography (HRCT) and pathological findings of primary alveolar proteinosis (PAP) and silicoproteinosis. Material and methods: The study included 15 patients with PAP (6 women, 9 men, mean age 31 years) and 13 with silicoproteinosis (13 men, mean age 29.5 years). PAP was diagnosed by lung biopsy in 13 and bronchoalveolar lavage in two patients and silicoproteinosis by bronchoalveolar lavage in 10 and autopsy in three cases. HRCT images were reviewed by two chest radiologists with consensus for the presence, extent and distribution of ground-glass opacities, septal thickening, consolidation and nodules. Radiological–pathological correlation was performed by one radiologist and one chest pathologist. Results: Seven (46%) patients with PAP were asymptomatic; the remainder presented slowly progressive dyspnea and dry cough. All silicoproteinosis patients had dry cough and rapidly progressive dyspnea. The most common HRCT finding on PAP was the crazy-paving pattern (93%). All cases had areas of geographic sparing in the affected lung. The most common finding in silicoproteinosis (92%) was dependent consolidation with calcification in 83%. Centrilobular nodules were common (85%). On pathology, both diseases demonstrated intra-alveolar accumulation of PAS material, thickening of interlobular septae and alveolar walls and no evidence of fibrosis. A few silica particles were seen in silicoproteinosis. Conclusion: Despite the pathological similarities, PAP and silicoproteinosis have distinct clinical and imaging features and prognosis. Bilateral crazy-paving pattern with areas of geographic sparing is characteristic for PAP. Silicoproteinosis presents with bilateral dependent consolidation often with areas of calcification. The crazy-paving pattern is not seen in silicoproteinosis.

  18. Clinical, pathological and molecular prognostic factors in prostate cancer decision-making process.

    Science.gov (United States)

    Pugliese, Dario; Palermo, Giuseppe; Totaro, Angelo; Bassi, Pier Francesco; Pinto, Francesco

    2016-03-01

    Prostate cancer is the most common urologic neoplasm and the second leading cause of cancer-related death among men in many developed countries. Given the highly heterogeneous behaviour of the disease, there is a great need for prognostic factors, in order to stratify the clinical risk and give the best treatment options to the patient. Clinical factors, such as prostate-specific antigen value and derivatives, and pathological factors, such as stage and Gleason grading, are well kown prognostic factors. Nomograms can provide useful prediction in each clinical sceario. The field of molecular biomarkers is briskly evolving towards personalized medicine. TMPRSS2-ERG fusion, deletion of PTEN ed and gene panels are some of the more extensively explored molecular features in prostate cancer outcome prediction. In the near future, circulating tumour cells, exosomes and microRNAs could give us further, not invasive important tools. PMID:26917215

  19. Pathological and clinical characteristics of 84 cases of non-Hodgkin's lymphoma

    OpenAIRE

    Hashtroudi H; Norouzi Z; Saljooghi N

    2000-01-01

    Non-Hodgkin's lymphoma is the 3rd most common cancers in children. In the present study, to determine pathological and clinical features of this cancer, we reviewed records of 84 cases of non-Hodgkin's lymphoma who were admitted to Ali Asghar and Bahrami children hospitals from 1989 to 1996. 59% of cases had small non-cleaved cell (SNCC) subtype of disease. 15% were lymphoblastic and 5% diffuse large cell subtype. The most prevalent primary sites were abdomen and lymph nodes. The mo...

  20. Levels of IL-17 and Th17/Treg ratio reflect clinical and pathological activity in patients with lupus nephritis

    Institute of Scientific and Technical Information of China (English)

    许嵘

    2014-01-01

    Objective To explore the correlation of Th17/Treg ratio and related cytokines with clinical and pathological activity in patients with lupus nephritis(LN).Methods The patients with lupus nephritis were enrolled into this study from June 2011 to Feb 2012.The demographic data,clinical activity and pathological index were recorded and analyzed in details.The frequency of Th17 and Treg+

  1. Analysis of clinical and pathological features of chronic hepatitis B in combination with hepatic steatosis in the elderly

    Institute of Scientific and Technical Information of China (English)

    董红筠

    2013-01-01

    Objective To explore the clinical and pathological characters of chronic hepatitis B (CHB) in combination with hepatic steatosis in the elderly.Methods Totally223 elderly patients with CHB and hepatic steatosis diagnosed by liver biopsy were retrospectively analyzed and220 non-elderly patients with CHB and hepatic steatosis were randomly selected as control group.Clinical and pathological features and change in liver histology were compared between the two groups.Results The inci-

  2. Relationship Between Clinical and Pathologic Features of Ductal Carcinoma in Situ and Patient Age: An Analysis of 657 Patients

    OpenAIRE

    Collins, Laura C.; Achacoso, Ninah; Nekhlyudov, Larissa; Fletcher, Suzanne W; Haque, Reina; Quesenberry, Charles P; Puligandla, Balaram; Alshak, Najeeb S.; Goldstein, Lynne C.; Gown, Allen M.; Schnitt, Stuart J.; Habel, Laurel A

    2009-01-01

    Prior studies have shown that young patient age at diagnosis is associated with an increased risk of local recurrence (LR) among women with DCIS treated with breast-conserving therapy. Whether this can be explained by differences in clinical or pathologic features of DCIS according to age is an unresolved issue. We compared clinical and pathologic features of DCIS among 657 women in four age groups:

  3. Prognostic influence of clinical and pathological factors in medullary thyroid carcinoma: a study of 53 cases

    Directory of Open Access Journals (Sweden)

    Lenine G. Brandão

    2009-01-01

    Full Text Available OBJECTIVES AND INTRODUCTION: Medullary thyroid carcinoma, a neoplasia of intermediate prognosis and differentiation, does not always respond predictably to known treatments. This study aimed to correlate the clinical progression of surgically treated patients with clinical and pathological data. METHODS: A total of 53 patients were followed for 75 months (mean average in tertiary-care hospital. The clinical status of patients at the end of the study period was characterized to determine correlations with a range of disease aspects. A value of p < 0.05 was considered statistically significant. RESULTS: Twenty-two patients (41.5% were alive and disease-free at the end of the follow-up period; twenty-three patients (43.4% had persistent disease; and eight patients (15.1% had recurrent disease. Four patients (7.6% died from medullary thyroid carcinoma with clinical and/or imaging evidence of neoplasia. The following aspects demonstrated statistically significant correlations with the final medical condition: positive initial cervical examination (p = 0.002; neoplastic extensions to the thyroid capsule (p = 0.004 and adjacent tissues (p = 0.034; cervical lymph node metastases (p < 0.001; diameter of neoplasia (p = 0.018; TNM (tumor, node and metastasis Stage (p = 0.001 and evidence of distant and/or cervical diseases in the absence of a cure (p = 0.011. Through logistic regression, the presence of cervical lymph node metastases was considered an independent variable (p < 0.001. CONCLUSIONS: Clinical and pathological aspects of patients with surgically treated medullary thyroid carcinomas are predictors of disease progression. Specifically, even treated cervical lymph node metastases are significantly correlated with disease progression.

  4. CLINICAL AND PATHOLOGICAL FINDINGS OF ASPERGILLOSIS IN MAGELLANIC PENGUINS (Spheniscus magellanicus

    Directory of Open Access Journals (Sweden)

    MELISSA ORZECHOWSKI XAVIER

    2011-09-01

    Full Text Available We studied a series of fifteen fatal cases of aspergillosis in penguins (Spheniscus magellanicus, seen over a 4-year period at a rehabilitation center in Southern Brazil. The clinical and pathological findings based on the lesions found at necropsy are described herein. The majority of animals (11/15 had sudden death without clinical signs. In 33.3% (5/15 of the cases, aspergillosis was restricted to the respiratory system and 66.6% showed disseminateddisease, with liver, kidney, adrenal gland and gastrointestinal tract involvement. Typical lesions were characterized as white-yellowish granulomatous nodules. To the best of our knowledge, this is the largest series of aspergillosis cases described in penguins in SouthAmerica.

  5. Pulmonary opacification in infants undergoing extracorporeal membrane oxygenation (ECMO): Clinical and pathologic correlation

    International Nuclear Information System (INIS)

    The authors reviewed the chest radiographs and clinical records of 18 infants with severe respiratory failure treated with extracorporeal membrane oxygenation (ECMO) in order to determine the correlation between degree of abnormality on chest radiographs and the clinical severity of disease. In addition, the results of postmortem examinations of the lungs of seven infants who died while undergoing ECMO therapy were reviewed and compared with the radiographic appearance of the lung within 24 hours of death. Changes in lung compliance and ECMO requirements correlated well with improving radiographic appearance. Pathologic changes were mainly those associated with intensive respiratory support and/or the underlying pulmonary condition of the patient. One patient had diffuse pulmonary hemorrhage

  6. Fatal pulmonary embolism in hospitalized patients. Clinical diagnosis versus pathological confirmation

    Directory of Open Access Journals (Sweden)

    Cláudio Tinoco Mesquita

    1999-09-01

    Full Text Available OBJECTIVE - To assess the incidence of fatal pulmonary embolism (FPE, the accuracy of clinical diagnosis, and the profile of patients who suffered an FPE in a tertiary University Hospital. METHODS - Analysis of the records of 3,890 autopsies performed at the Department of General Pathology from January 1980 to December 1990. RESULTS - Among the 3,980 autopsies, 109 were cases of clinically suspected FPE; of these, 28 cases of FPE were confirmed. FPE accounted for 114 deaths, with clinical suspicion in 28 cases. The incidence of FPE was 2.86%. No difference in sex distribution was noted. Patients in the 6th decade of life were most affected. The following conditions were more commonly related to FPE: neoplasias (20% and heart failure (18.5%. The conditions most commonly misdiagnosed as FPE were pulmonary edema (16%, pneumonia (15% and myocardial infarction (10%. The clinical diagnosis of FPE showed a sensitivity of 25.6%, a specificity of 97.9%, and an accuracy of 95.6%. CONCLUSION - The diagnosis of pulmonary embolism made on clinical grounds still has considerable limitations.

  7. Hepatolithiasis and the syndrome of recurrent pyogenic cholangitis: clinical, radiologic, and pathologic features.

    Science.gov (United States)

    Tsui, Wilson Man-shan; Chan, Yiu-kay; Wong, Chi-tat; Lo, Yan-fai; Yeung, Yat-wah; Lee, Yat-wing

    2011-02-01

    Primary hepatothiasis (HL) and recurrent pyogenic cholangitis (RPC) are two terms describing the different aspects of the same disease, with HL emphasizing the pathologic changes and RPC emphasizing the clinical presentation and suppurative inflammation. It is predominantly a disease of the Far East. In the 1960s, it was the third most common cause of emergency abdominal surgery at a university hospital in Hong Kong. Thereafter, its incidence has decreased considerably, possibly due to improved standards of living and Westernized diet. Clinically, patients may present acutely with recurrent bacterial cholangitis and its possible complications, such as liver abscess and septicemic shock, or with chronic complications, such as cholangiocarcinoma. Pathologically, it is characterized by pigmented calcium bilirubinate stones within dilated intrahepatic bile ducts featuring chronic inflammation, mural fibrosis, and proliferation of peribiliary glands, without extrahepatic biliary obstruction. Episodes of suppurative inflammation cumulate in sclerosing cholangitis of peripheral ducts and parenchymal fibrosis resulting from collapse and scarring. Mass-forming inflammatory pseudotumor and neoplasms like intraductal papillary neoplasms and cholangiocarcinoma are increasingly recognized complications. Modern imaging techniques allow definitive diagnosis, accurate assessment for treatment planning, and detection of complications. A multidisciplinary team approach (interventional endoscopist, interventional radiologist, hepatobiliary surgeon, and intensivists) is important for optimal patient outcome. PMID:21344349

  8. Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression.

    Science.gov (United States)

    Sato, Katsuaki; Suda, Kenichi; Shimizu, Shigeki; Sakai, Kazuko; Mizuuchi, Hiroshi; Tomizawa, Kenji; Takemoto, Toshiki; Nishio, Kazuto; Mitsudomi, Tetsuya

    2016-01-01

    The receptor tyrosine kinase AXL is a member of the Tyro3-Axl-Mer receptor tyrosine kinase subfamily. AXL affects several cellular functions, including growth and migration. AXL aberration is reportedly a marker for poor prognosis and treatment resistance in various cancers. In this study, we analyzed clinical, pathological, and molecular features of AXL expression in lung adenocarcinomas (LADs). We examined 161 LAD specimens from patients who underwent pulmonary resections. When AXL protein expression was quantified (0, 1+, 2+, 3+) according to immunohistochemical staining intensity, results were 0: 35%; 1+: 20%; 2+: 37%; and 3+: 7% for the 161 samples. AXL expression status did not correlate with clinical features, including smoking status and pathological stage. However, patients whose specimens showed strong AXL expression (3+) had markedly poorer prognoses than other groups (P = 0.0033). Strong AXL expression was also significantly associated with downregulation of E-cadherin (P = 0.025) and CD44 (P = 0.0010). In addition, 9 of 12 specimens with strong AXL expression had driver gene mutations (6 with EGFR, 2 with KRAS, 1 with ALK). In conclusion, we found that strong AXL expression in surgically resected LADs was a predictor of poor prognosis. LADs with strong AXL expression were characterized by mesenchymal status, higher expression of stem-cell-like markers, and frequent driver gene mutations. PMID:27100677

  9. Residency training programs in veterinary clinical pathology: a comparison of experiences at two institutions.

    Science.gov (United States)

    Raskin, Rose E

    2007-01-01

    Two institutions with different residency training formats in clinical pathology are compared with respect to application procedures, learning and teaching opportunities, learning resources, research training, publication requirements, and assessment methods of the program and trainees. The University of Florida and Purdue University programs are both based on an emphasis in morphologic recognition and interpretation of disease processes as well as training in basic science and applied research principles. The progress of trainees through each program is carefully monitored to meet individual needs as well as to meet the training requirements to allow candidates to sit for the certifying examination in clinical pathology. Periodic mock board exams are a critical tool to assess trainee progress and learning. The differences in format focus on coursework and publication requirements as well as on program assessment tools. While one program provides training in the form of 75% clinical diagnostic service, the other uses a mixture of 50% coursework and 50% clinical diagnostic training. Despite the contrast between a pure residency training program and one combining residency training with an MS degree, both institutions provide a solid program structure, ample learning resources, and adequate faculty mentorship to produce a high pass rate of board-certified specialists, the major focus for both programs. Numbers of post-training employment positions for both institutions are similar for those selecting faculty positions at veterinary schools. During the period studied, however, the combined residency and MS graduate program at Purdue University produced more graduates employed in pharmaceutical and biotechnology companies, while the residency program at the University of Florida produced more graduates employed by diagnostic laboratories. PMID:18287476

  10. Diffuse lung uptake (DLU) on Ga-67 scintigraph: Clinical, radiologic and pathologic correlation

    International Nuclear Information System (INIS)

    Review, analysis and correlation (clinical, radiologic and pathologic) of 29 consecutive adults (16 drug addicts and/or homosexuals) with DLU on Ga-67 scintigraph were made. Diffuse increased uptake of at least 75% of both lungs was considered as DLU. WFOF cameras were used to obtain 24 to 96 hr. scintigraphs after IV injection of 3-5 mCi of Ga-67 citrate. In 26, tissue diagnosis established: pneumocystis carinii (PC) 15, miliary tuberculosis (TB) 3, sarcoidosis (SR) 3, drug-induced toxicity 2, and toxoplasmosis (TX), primary hyperparathyroidism and nonspecific lymphocytic pneumonia-one each. In two with breast and one with esophageal carcinomas, no lung tissue diagnosis was sought. Concurrent chest x-rays were negative in 16, but in 7/16, lung infiltrate was later documented. An average of 31 days elapsed before x-rays became positive in four with PC, 7 days in two with TB, and 22 days in one with TX. In 13, concurrent x-rays showed lung infiltrate, but in 6, only subtle, localized rather than diffuse infiltrate was noted. Fourteen of 29 had at least two Ga-67 studies. In 12 (7 PC, 2 TB, 3 SR) of 14 whose repeat studies showed significant to total disappearance of DLU, all did well clinically. In two whose initial studies were negative or equivocal, they became clinically worse when the repeat study showed DLU. In three others (2 PC, 1 TX) who died, their single studies recorded intense DLU. DLU on gallium scintigraph indicated a variety of pathology. In 55.2%, gallium scintigraph predated x-ray findings by a few days to weeks. In 20.3%, x-ray findings were only subtle or localized. Scintigraphic changes correlated well with the clinical courses in various diseases

  11. Clinical Factors Predicting the Pathologic Tumor Response after Preoperative Concurrent Chemoradiotherapy for Rectal Cancer

    International Nuclear Information System (INIS)

    The objective of this retrospective study was to identify predictive factors for the complete pathologic response and tumor down staging after preoperative concurrent chemoradiotherapy for locally advanced rectal cancer. Materials and Methods: Between the years 2000 and 2008, 39 patients with newly diagnosed rectal cancer without prior evidence of distant metastasis received preoperative concurrent chemoradiotherapy followed by surgery. The median radiation dose was 50.4 Gy (range, 45-59.4 Gy). Thirty-eight patients received concurrent infusional 5-fluorouracil and leucovorin, while one patient received oral capecitabine twice daily during radiotherapy. Results: A complete pathologic response (CR) was demonstrated in 12 of 39 patients (31%), while T-downstaging was observed in 24 of 39 patients (63%). N-downstaging was observed in 18 of 28 patients (64%), with a positive node in the CT scan or ultrasound. Two patients with clinical negative nodes were observed in surgical specimens. The results from a univariate analysis indicated that the tumor circumferential extent was less than 50% (p=0.031). Moreover, the length of the tumor was less than 5 cm (p=0.004), while the post-treatment carcinoembryonic antigen (CEA) levels were less than or equal to 3.0 ng/mL (p=0.015) and were significantly associated with high pathologic CR rates. The univariate analysis also indicated that the adenocarcinoma (p=0.045) and radiation dose greater than or equal to 50 Gy (p=0.021) were significantly associated with high T-downstaging, while a radiotherapy duration of less than or equal to 42 days (p=0.018) was significantly associated with N-downstaging. The results from the multivariate analysis indicated that the lesser circumferential extent of the tumor (hazard ratio [HR], 0.150; p=0.028) and shorter tumor length (HR, 0.084; p=0.005) independently predicted a higher pathologic CR. The multivariate analysis also indicated that a higher radiation dose was significantly associated

  12. Detection of pathological biomarkers in human clinical samples via amplifying genetic switches and logic gates.

    Science.gov (United States)

    Courbet, Alexis; Endy, Drew; Renard, Eric; Molina, Franck; Bonnet, Jérôme

    2015-05-27

    Whole-cell biosensors have several advantages for the detection of biological substances and have proven to be useful analytical tools. However, several hurdles have limited whole-cell biosensor application in the clinic, primarily their unreliable operation in complex media and low signal-to-noise ratio. We report that bacterial biosensors with genetically encoded digital amplifying genetic switches can detect clinically relevant biomarkers in human urine and serum. These bactosensors perform signal digitization and amplification, multiplexed signal processing with the use of Boolean logic gates, and data storage. In addition, we provide a framework with which to quantify whole-cell biosensor robustness in clinical samples together with a method for easily reprogramming the sensor module for distinct medical detection agendas. Last, we demonstrate that bactosensors can be used to detect pathological glycosuria in urine from diabetic patients. These next-generation whole-cell biosensors with improved computing and amplification capacity could meet clinical requirements and should enable new approaches for medical diagnosis. PMID:26019219

  13. Does the choice of display system influence perception and visibility of clinically relevant features in digital pathology images?

    Science.gov (United States)

    Kimpe, Tom; Rostang, Johan; Avanaki, Ali; Espig, Kathryn; Xthona, Albert; Cocuranu, Ioan; Parwani, Anil V.; Pantanowitz, Liron

    2014-03-01

    Digital pathology systems typically consist of a slide scanner, processing software, visualization software, and finally a workstation with display for visualization of the digital slide images. This paper studies whether digital pathology images can look different when presenting them on different display systems, and whether these visual differences can result in different perceived contrast of clinically relevant features. By analyzing a set of four digital pathology images of different subspecialties on three different display systems, it was concluded that pathology images look different when visualized on different display systems. The importance of these visual differences is elucidated when they are located in areas of the digital slide that contain clinically relevant features. Based on a calculation of dE2000 differences between background and clinically relevant features, it was clear that perceived contrast of clinically relevant features is influenced by the choice of display system. Furthermore, it seems that the specific calibration target chosen for the display system has an important effect on the perceived contrast of clinically relevant features. Preliminary results suggest that calibrating to DICOM GSDF calibration performed slightly worse than sRGB, while a new experimental calibration target CSDF performed better than both DICOM GSDF and sRGB. This result is promising as it suggests that further research work could lead to better definition of an optimized calibration target for digital pathology images resulting in a positive effect on clinical performance.

  14. Clinical and pathological features of intracranial meningiomas in children: A retrospective analysis

    Institute of Scientific and Technical Information of China (English)

    Kun Yang; Lisheng He; Linsun Dai; Jian Chen; Zhixiong Lin

    2006-01-01

    BACKGROUND:The attack of meningiomas has sex and age differences.Previous studies indicated that children and adult patients had different clinical and pathological features.Due to the limitation of conditions and technique of diagnosis and treatment,some clinical and pathological features of meningiomas in children should be further recognized.OBJECTIVE:To summarize the clinical and pathological features in 15 children with intracranial meningiomas.DESIGN:A retrospective case analysis.SETTING:The hospitals which the first author had been working in.PARTIClPANTS:Fifteen children with intracranial meningiomas were selected from the hospitals the first author had been working in from June 1996 to June 2006.There were 9 boys and 6 gids,aged 1.8-15 years,with an average of 9.8 years.The duration from attack to diagnosis was 1 month to 2.5 years,with an average of 13months.Inclusive criteria:①Clinically diagnosed,operated and confirmed pathologically;②≤15 years;③The children and their relatives were all informed and agree with the detection.METHODS:The clinical manifestations,imaging data,preoperative diagnosis and misdiagnosis,site and size of tumor,operative treatment and pathological data were retrospectively summarized.Thirteen of 15 children with intracranial meningiomas were followed up by means of reexamination for 1-8 years.and the postoperative recurrence were observed.HAIN OUTCOME MEASURES:Clinical manifestations,imaging data,preoperative diagnosis and misdiagnosis,site and size of tumor,operative treatment,pathological data,recurrence conditions of 1 to 8 years follow-up.RESULTS:Thirteen of the 15 children with intracranial meningiomas were involved in the analysis of results.and 2 lost to the follow-up. ①The main clinical manifestations at diagnosis were headache in 11 cases(73%,11/5),vomiting in 8 cases(53%,8/15),papilledema in 9 cases(60%,9/15),hypopsia in 6 cases (40%,6/15),epilepsy in 5 cases(33%,5,15).hemiplegia in 4 cases(27%,4/15),cranial

  15. Outcomes assessment of case-based writing exercises in a veterinary clinical pathology course.

    Science.gov (United States)

    Sharkey, Leslie; Michael, Helen; LeBeau, Brandon; Center, Bruce; Wingert, Deb

    2012-01-01

    Our second-year core clinical pathology course uses free-response case-based learning exercises in an otherwise traditional lecture or laboratory course format to augment the development of skills in application of knowledge and critical thinking and clinical reasoning. We previously reported increased learner confidence accompanied by perceived improvements in understanding and ability to apply information, along with enhanced feelings of preparedness for examinations that students attributed to the case-based exercises. The current study prospectively follows a cohort of students to determine the ability of traditional multiple-choice versus free-response case-based assessments to predict future academic performance and to determine if the perceived value of the case-based exercises persists through the curriculum. Our data show that after holding multiple-choice scores constant, better performance on case-based free-response exercises led to higher GPA and better class rank in the second and third years and better class rank in the fourth year. Students in clinical rotations reported that the case-based approach was superior to traditional lecture or multiple-choice exam format for learning clinical reasoning, retaining factual information, organizing information, communicating medical information clearly to colleagues in clinical situations, and preparing high quality medical records. In summary, this longitudinal study shows that case-based free-response writing assignments are efficacious above and beyond standard measures in determining students' GPAs and class rank and in students' acquisition of knowledge, skills, and clinical reasoning. Students value these assignments and overwhelmingly find them an efficient use of their time, and these opinions are maintained even two years following the course. PMID:23187033

  16. The Structure of Pathological Gambling among Korean Gamblers: A Cluster and Factor Analysis of Clinical and Demographic Characteristics

    Science.gov (United States)

    Lee, Tae Kyung; LaBrie, Richard A.; Grant, Jon E.; Kim, Suck Won; Shaffer, Howard J.

    2008-01-01

    This paper reports the underlying structure of the demographic and clinical characteristics of level 3 (i.e., pathological) Korean casino gamblers. The participants reported their gambling behavior and clinical characteristics known to be associated with gambling problems (e.g., alcohol use problems, eating disorders, depression, anxiety, and…

  17. Epidemiological, clinical and pathological features of primary cardiac hemangiosarcoma in dogs: a review of 51 cases.

    Science.gov (United States)

    Yamamoto, Shinya; Hoshi, Katsuichiro; Hirakawa, Atsushi; Chimura, Syuuichi; Kobayashi, Masayuki; Machida, Noboru

    2013-11-01

    In the study presented here, we aimed to describe the epidemiological, clinical and pathological findings of 51 canine cases with histologically-verified diagnoses of primary cardiac hemangiosarcoma (HSA). The medical data for each dog, including signalment, presenting complaints, physical examination findings, results of various diagnostic testing performed and method of treatment, were checked. In addition, all 51 cases were re-examined pathologically. The tumor occurred most frequently in older Golden Retrievers, followed by Maltese dogs and Miniature Dachshunds. Mass lesions of HSA were found more commonly in the right auricle (RAu) (25/51) and right atrium (RA) (21/51), and the RA masses were significantly (Pdogs that received adjuvant chemotherapy after tumor resection than for 12 dogs that did not. In this series, the Maltese (9/51) and Miniature Dachshund (7/51), as well as the Golden Retriever, were represented more frequently than other breeds. The lower echocardiographic detection rate of RAu masses compared with RA masses may be related to tumor size and/or location. The significantly longer survival time for dogs receiving adjuvant chemotherapy indicates that postoperative chemotherapy could be useful for dogs with cardiac HSA. PMID:23811814

  18. Diagnosis and clinic-pathological findings of influenza virus infection in Brazilian pigs

    Directory of Open Access Journals (Sweden)

    Daniela S. Rajão

    2013-01-01

    Full Text Available Influenza A virus (IAV is a respiratory pathogen of pigs and is associated with the porcine respiratory disease complex (PRDC, along with other respiratory infectious agents. The aim of this study was to diagnose and to perform a clinic-pathological characterization of influenza virus infection in Brazilian pigs. Lung samples from 86 pigs in 37 farrow-to-finish and two farrow-to-feeder operations located in the States of Minas Gerais, São Paulo, Paraná, Rio Grande do Sul, Santa Catarina, and Mato Grosso were studied. Virus detection was performed by virus isolation and quantitative real time reverse-transcription PCR (qRT-PCR. Pathologic examination and immunohistochemistry (IHC were performed in 60 lung formalin-fixed paraffin-embedded tissue fragments. Affected animals showed coughing, sneezing, nasal discharge, hyperthermia, inactivity, apathy, anorexia, weight loss and growth delay, which lasted for five to 10 days. Influenza virus was isolated from 31 (36.0% lung samples and 36 (41.9% were positive for qRT-PCR. Thirty-eight (63.3% lung samples were positive by IHC and the most frequent microscopic lesion observed was inflammatory infiltrate in the alveoli, bronchiole, or bronchi wall or lumen (76.7%. These results indicate that influenza virus is circulating and causing disease in pigs in several Brazilian states.

  19. Clinical pathology and parasitologic evaluation of free-living nestlings of the Hyacinth Macaw (Anodorhynchus hyacinthinus).

    Science.gov (United States)

    Allgayer, M C; Guedes, N M R; Chiminazzo, C; Cziulik, M; Weimer, T A

    2009-10-01

    This study evaluated the health status and established hematologic and serum biochemistry parameters for free-living nestlings of the Hyacinth Macaw (Anodorhynchus hyacinthinus) from the Brazilian Pantanal (19 degrees 51'-19 degrees 58'S; 56 degrees 17'-56 degrees 24'W), for four consecutive years (from December 2003 through December 2006). Physical examinations indicated that all the birds were in good health. Endoparasites and blood parasites were not detected in any of the nestlings, and ectoparasites seemed to be limited to Philornis sp. (Diptera: Muscidae). Significantly higher levels of total white blood cells and heterophils, glucose, total protein, triglycerides, and phosphorus were observed in females. In females, higher cholesterol levels and packed cell volumes were observed in older birds, and total white blood cell and heterophil counts were higher in young animals. In males, uric acid levels were higher in older individuals. Wild Pantanal Hyacinth Macaws feed on only two species of palm nuts (Acrocomia totai and Scheelea phalerta). This limited food habit has a strong impact on population size and may alter the clinical pathology parameters of these birds. Therefore, knowledge of blood levels in normal individuals is essential to assess the physiologic and pathologic condition of wild macaws, to assess the effects of environmental changes on their health, and to contribute to conservation strategies of this endangered species. PMID:19901373

  20. Feline infectious peritonitis with neurologic involvement: clinical and pathological findings in 24 cats

    International Nuclear Information System (INIS)

    The medical records of 24 cats with histopathologically diagnosed feline infectious peritonitis involving the nervous system were reviewed. Seventeen cats had historical, clinical, and pathological findings of systemic disease. Twelve cats had focal signs of central nervous system dysfunction. Twelve cats had multifocal signs including seizures, nystagmus, head tilt, vestibular or cerebellar ataxia, paresis, and proprioceptive loss with a preponderance of caudal fossa signs. Computed tomography of the brain revealed hydrocephalus in two cats. Examination of cerebrospinal fluid revealed pyogranulomatous pleocytosis in fivecats; the tap was nonproductive in five cats. Findings on histopathological examination of appropriate tissues included nephritis, hepatitis, and pleuritis. Neuropathological findings included ependymitis, choroid plexitis, meningitis, encephalitis, and myelitis. Hydrocephalus was seen in 18 cats on necropsy

  1. Clinical and pathological aspects of multicentric hemangiosarcoma in a Pinscher dog

    Directory of Open Access Journals (Sweden)

    B.D.C. Martins

    2013-04-01

    Full Text Available A 3-year-old female Pinscher dog was presented with a history of lameness and pain in hind limbs for one week which acutely progressed to non-ambulatory paraparesis. The dog had been apathetic and anorexic during the six days prior to presentation. The neurological findings were compatible with upper motor neuron signs to the left hind limb due to a spinal cord compressive mass on the twelfth thoracic vertebral body. On the other hand, signs of lower motor neurons to the right hind limb were due to a mass with a pathological fracture in the right proximal femur, compressing the sciatic nerve. A histopathological analysis of all organs revealedthe proliferation of endothelial cells showingin filtrative growth and organization into vascular structures with a solid pattern. In addition, immunohistochemycal analysis revealed low proliferation index and citoplasmatic positivity for CD-31, confirming the vascular nature of the neoplasm. Clinical, histopathological and immunophenotipical findings were consistent with hemangiosarcoma.

  2. Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma

    Directory of Open Access Journals (Sweden)

    Sean Huang

    2015-01-01

    Full Text Available A 78-year-old man presented with an enlarging, tender mass in the scrotum separate to the testes. This was on the background of radical cystoprostatectomy, urethrectomy, and ileal conduit formation for high-grade urothelial carcinoma of the bladder invading submucosa 3 years prior. Examination revealed a 4 × 5 cm lesion, which was hard, fixed to the overlying skin and nodular to palpation. Ultrasound confirmed a solid mass in the scrotum extending into the perineum. Computerized tomography of the chest, abdomen, and pelvis revealed enlargement of inguinal lymph nodes but no other metastases. Complete resection of the scrotal lesion and selective removal of regional lymph nodes was performed. Rather than a cutaneous scrotal metastasis from the bladder urothelial carcinoma, histological examination suggested a primary apocrine adenocarcinoma of the scrotum. This case report explores the clinical and pathological features associated with both of these unusual differential diagnoses.

  3. Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma.

    Science.gov (United States)

    Huang, Sean; Frydenberg, Mark; Pham, Alan; Grummet, Jeremy P

    2015-01-01

    A 78-year-old man presented with an enlarging, tender mass in the scrotum separate to the testes. This was on the background of radical cystoprostatectomy, urethrectomy, and ileal conduit formation for high-grade urothelial carcinoma of the bladder invading submucosa 3 years prior. Examination revealed a 4 × 5 cm lesion, which was hard, fixed to the overlying skin and nodular to palpation. Ultrasound confirmed a solid mass in the scrotum extending into the perineum. Computerized tomography of the chest, abdomen, and pelvis revealed enlargement of inguinal lymph nodes but no other metastases. Complete resection of the scrotal lesion and selective removal of regional lymph nodes was performed. Rather than a cutaneous scrotal metastasis from the bladder urothelial carcinoma, histological examination suggested a primary apocrine adenocarcinoma of the scrotum. This case report explores the clinical and pathological features associated with both of these unusual differential diagnoses. PMID:25657556

  4. [Retracted] Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy.

    Science.gov (United States)

    Liu, Xinhong; Wu, Huamin; Gong, Jian; Wang, Tao; Yan, Chuanzhu

    2016-07-01

    We wish to retract our article entitled 'Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy' published in Molecular Medicine Reports 13: 4273-4278, 2016. The article was submitted by the first author, Xinhong Liu, without the prior knowledge of the corresponding author, Chuanzhu Yan, or the other authors included on the paper. Furthermore, the details of the paper were not discussed by the authors prior to the submission, and all are in agreement that the paper contains data therein (and interpretations thereof) which are either inaccurate or inappropriate. All the authors agree to this retraction, and we apologize for the inconvenience caused in this regard.[the original article was published in the Molecular Medicine Reports 13: 4273-4278, 2016; DOI: 10.3892/mmr.2016.5047]. PMID:27176730

  5. Influence of Clinical and Pathologic Parameters on Prognosis of Cervical Carcinoma in China

    Institute of Scientific and Technical Information of China (English)

    LUPing; LIANGQiudong; ZHENGQuanqing

    2003-01-01

    Objective: To explore the influence of clinical and pathologic parameters on the prognosis of squamous cell carcinoma and adenocarcinoma. Methods: 702 cases of cervical carcinoma were retrospec-tively studied. Cox regression model was informed in multi-variable analysis. Results: The retrospective analysis showed that 630 out of 702 cases of cervical carcinoma were squamous cell carcinoma, cumulative rate 89.4% and 72 case were adenocarcinoma, cumulative rate 10.6% respectively. The 5-year survival rate was lower for patients with adenocarcinoma than for patients with squamous cell carcinoma (58.3% vs 57.3%), but there was no significant difference. Cox regression model showed that the variable into equation for squamous cell carcinoma included tumor grade of differentiation, lymph node metastasis and FIGO stage, but only lymph node metastasis and FIGO stage for adenocarcinoma. Conclusion: FIGO stage and lymph node metastasis was independent parameter evaluating prognosis of cervical carcinoma.

  6. Pathological and clinical characteristics of 84 cases of non-Hodgkin's lymphoma

    Directory of Open Access Journals (Sweden)

    Hashtroudi H

    2000-08-01

    Full Text Available Non-Hodgkin's lymphoma is the 3rd most common cancers in children. In the present study, to determine pathological and clinical features of this cancer, we reviewed records of 84 cases of non-Hodgkin's lymphoma who were admitted to Ali Asghar and Bahrami children hospitals from 1989 to 1996. 59% of cases had small non-cleaved cell (SNCC subtype of disease. 15% were lymphoblastic and 5% diffuse large cell subtype. The most prevalent primary sites were abdomen and lymph nodes. The most prevalent symptoms were abdominal mass (34%, abdominal pain (37% and cervcal lymphadenopathy (26%. Over half of our patients were small non-cleaved cell subtype, and further studies should be done to find out reasons for this unusual finding.  

  7. Clinical and pathological changes in rams experimentally infected with Actinobacillus seminis and Histophilus somni.

    Science.gov (United States)

    Moustacas, Valéria S; Silva, Teane M A; Costa, Luciana F; Carvalho Júnior, Custódio A; Santos, Renato L; Paixão, Tatiane A

    2014-01-01

    Infectious epididymitis is considered a major cause of economic losses for the sheep industry worldwide. This study aimed to investigate clinical and pathological changes associated with experimental infections with A. seminis and H. somni in rams. Twenty rams of age 18 to 24 months were infected by intraepididymal inoculation of A. seminis (n = 10) and H. somni (n = 10). Rams were weekly examined and biological samples were collected during six weeks. All rams inoculated with A. seminis and 80% inoculated with H. somni became infected. The recovery of bacteria was possible in semen and urine samples and tissues in both experimental groups. Clinically, there were a decrease in testicular consistency and an increase in measures of the left epididymis tails in both experimental groups. The main gross changes were observed in the reproductive tract. Microscopically, the main lesions were inflammatory changes in the genitourinary tract and testicular degeneration. A. seminis and H. somni were able to colonize several organs of the genitourinary tract in rams, being indistinguishable by clinical exam, necropsy or histopathology. For differential diagnosis, it is important to use diagnostic techniques for direct confirmation of the etiologic agent. PMID:24592151

  8. Infantile hemangioendothelioma of the liver: a radiologic-pathologic-clinical correlation

    International Nuclear Information System (INIS)

    Infantile hemangioendothelioma is the most common symptomatic vascular liver tumor of infancy. It is considered a benign tumor; however, aggressive behavior is occasionally seen microscopically, and rarely distant metastases have been reported. The exact incidence of infantile hemangioendothelioma is difficult to determine because often it has been either misdiagnosed or mislabeled as cavernous hemangioma in the literature. Cavernous hemangioma is the most common primary liver tumor in older age groups but is rarely found in infants as a clinically significant tumor. Levick and Rubie were the first to recognize an association between hemangioendothelioma of the liver and congestive heart failure, and there were subsequent reports substantiating this association. However, it is our impression and the finding of others that congestive heart failure is distinctly less common than abdominal mass or hepatomegaly as the presenting sign in infantile hemangioendothelioma. Congestive heart failure is rarely a feature of cavernous hemangioma. Because of the errors in terminology and questions regarding clinical presentation, a radiologic-pathologic-clinical correlation study of infantile hemangioendothelioma and review of the literature was undertaken

  9. Clinical and pathological study of an outbreak of obstructive urolithiasis in feedlot cattle in southern Brazil

    Directory of Open Access Journals (Sweden)

    Loretti Alexandre Paulino

    2003-01-01

    Full Text Available The epidemiology, clinical picture and pathology of an outbreak of urolithiasis in cattle in southern Brazil are described. The disease occurred in August 1999 in a feedlot beef cattle herd. Five out of 1,100 castrated steers were affected. Clinical signs included colic and ventral abdominal distension. White, sand-grain-like mineral deposits precipitated on the preputial hairs. Affected cattle died spontaneously 24-48 hrs after the onset of the clinical signs. Only one animal recovered after perineal urethrostomy. Necropsy findings included calculi blocking the urethral lumen of the distal portion of the penile sigmoid flexure, urinary bladder rupture with leakage of urine into the abdominal cavity and secondary fibrinous peritonitis. Daily water intake was low since water sources were scarce and not readily available. The animals were fed rations high in grains and received limited amounts of roughage. Biochemical analysis revealed that the calculi were composed of ammonium phosphate. A calcium-phosphorus imbalance (0.4:0.6 was detected in the feedlot ration. For the outbreak, it is suggested that contributing factors to urolith formation include insufficient fiber ingestion, low water intake and high dietary levels of phosphorus. No additional cases were observed in that feedlot after preventive measures were established. Similar dietary mismanagement in fattening steers has been associated with obstructive urolithiasis in feedlot beef cattle in other countries.

  10. Analysis of clinical factors for pathological complete response after preoperative neoadjuvant chemoradiotherapy for rectal cancer

    International Nuclear Information System (INIS)

    Objective: To evaluate the clinical factors associated with pathological complete response (pCR) after preoperative neoadjuvant chemoradiotherapy for rectal cancer. Methods: A retrospective analysis was performed on the clinical data of 116 patients with rectal cancer, who underwent neoadjuvant chemoradiotherapy followed by radical surgery from January 2009 to December 2012. All patients received pelvic intensity-modulated radiotherapy (50 Gy/25 fractions) with concurrent fluorouracil based chemotherapy and then underwent radical surgery 4-8 weeks later. The clinical factors associated with pCR or non-pCR were analyzed by Logistic regression. Results: Of the 116 patients, 20 (17.2%) achieved a pCR after neoadjuvant chemoradiotherapy. The univariate analysis showed that percentage of circumference of the rectal tube invaded by the tumor, preoperative serum carcinoembryonic antigen (CEA) level, T stage, N stage, distance from the anal verge, degree of tumor differentiation, and maximum tumor diameter were associated with pCR or non-pCR after neoadjuvant chemoradiotherapy for rectal cancer. The multivariate analysis revealed that percentage of circumference of the rectal tube invaded by the tumor, preoperative serum CEA level,and T stage were predictive factors for pCR or non-pCR after neoadjuvant chemoradiotherapy for rectal cancer. Conclusions: Non-circumferential tumor (percentage of circumference of the rectal tube invaded by the tumor <75 %), low CEA level, and early T stage before treatment may be associated with pCR after neoadjuvant chemoradiotherapy for rectal cancer. (authors)

  11. Co-existence of dual intracranial pathology clinical relevance of proton MRS.

    Directory of Open Access Journals (Sweden)

    Tripathi R

    2000-10-01

    Full Text Available The co-existence of neuro-cysticercosis (NCC and intracranial neoplasm in an individual is a rare entity. Atypical presentation of cerebral cysticercosis may mimic glioma, metastasis, cerebral abscess or vice versa. The dual existence of these two lesions have led to several postulates which may have clinical impact in due course of time i.e. NCC as an oncogenetic factor for glioma or similarity of antigen found in glioma and NCC etc. An adequate management of such cases poses a challenge to both imageologists as well as clinicians. Thus, a proper diagnostic evaluation is essential for successful management of such cases. MR spectroscopy (MRS, although still a clinical research tool, may be extremely useful for exclusion or confirmation of neoplastic lesions in such a clinical scenario. The findings of MRS in collaboration with imaging parameters may increase the diagnostic yield of a MR investigation. The authors encountered five cases of dual intracranial pathologies i.e. neurocysticercosis and glioma. MR spectroscopy was useful to arrive at a definitive diagnosis in such a situation.

  12. LUPUS NEPHRITIS COMPLICATED WITH MALIGNANT HYPERTENSION: FROM RENAL VASCULAR PATHOLOGY TO CLINICAL RELEVANCE

    Institute of Scientific and Technical Information of China (English)

    Jian-ling Tao; Hang Li; Yu Tang; Yu-bing Wen; Xue-wang Li

    2008-01-01

    Objective To investigate the clinical and pathological characteristics of lupus nephritis patients complicated with malignant hypertension.Methods We retrospectively studied 19 patients with lupus nephritis complicated with malignant hypertension who underwent renal biopsy between January 2002 and December 2006.Results Of 19 patients, 3 were men and 16 were women, with a mean age of 24. 4±7. 7 years old. All had positive antinuclear antibodies and low serum complement was found in 13 patients. All were anemic and 12 of them were thrombocytopenic. Impaired renal function was found in 17 patients with an average serum creatinine of 184. 5 ± 88.9 μmol/L. Severe intrarenai arteriolar lesion was found in all patients. Six patients had lupus vasculopathy, 11 patients had renal thrombotic microangiopathy lesion, 2 had severe arteriosclerosis. All patients received steroids and immunosuppressive drugs, 15 received angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker ( ARB ) with resultant well-controlled blood pressure. Thrombocytopenia and hemolytic anemia resolved remarkably.The renal function improved or recovered in 14 of 17 patients, and 3 developed end-stage renal disease on maintenance dialysis.Conclusions Severe intrarenal vascular lesion complicated with renal nephritis parallels clinical manifestation of malignant hypertension. Renal pathology is the key of treatment strategy emphasizing on the significance of renal vascular involvement and type. On the basis of immunosuppressive drugs and steroids to control systemic lupus activity, timely initiation of ACEI/ARB could be of benefit to blood pressure control and long term renal survival.

  13. Implementation of Epic Beaker Clinical Pathology at an academic medical center

    Directory of Open Access Journals (Sweden)

    Matthew D Krasowski

    2016-01-01

    Full Text Available Background: Epic Beaker Clinical Pathology (CP is a relatively new laboratory information system (LIS operating within the Epic suite of software applications. To date, there have not been any publications describing implementation of Beaker CP. In this report, we describe our experience in implementing Beaker CP version 2012 at a state academic medical center with a go-live of August 2014 and a subsequent upgrade to Beaker version 2014 in May 2015. The implementation of Beaker CP was concurrent with implementations of Epic modules for revenue cycle, patient scheduling, and patient registration. Methods: Our analysis covers approximately 3 years of time (2 years preimplementation of Beaker CP and roughly 1 year after using data summarized from pre- and post-implementation meetings, debriefings, and the closure document for the project. Results: We summarize positive aspects of, and key factors leading to, a successful implementation of Beaker CP. The early inclusion of subject matter experts in the design and validation of Beaker workflows was very helpful. Since Beaker CP does not directly interface with laboratory instrumentation, the clinical laboratories spent extensive preimplementation effort establishing middleware interfaces. Immediate challenges postimplementation included bar code scanning and nursing adaptation to Beaker CP specimen collection. The most substantial changes in laboratory workflow occurred with microbiology orders. This posed a considerable challenge with microbiology orders from the operating rooms and required intensive interventions in the weeks following go-live. In postimplementation surveys, pathology staff, informatics staff, and end-users expressed satisfaction with the new LIS. Conclusions: Beaker CP can serve as an effective LIS for an academic medical center. Careful planning and preparation aid the transition to this LIS.

  14. Predictors of treatment outcome among Asian pathological gamblers (PGs): clinical, behavioural, demographic, and treatment process factors.

    Science.gov (United States)

    Guo, Song; Manning, Victoria; Thane, Kyaw Kyaw Wai; Ng, Andrew; Abdin, Edimansyah; Wong, Kim Eng

    2014-03-01

    Research on predictors of treatment outcome among pathological gamblers (PGs) is inconclusive and dominated by studies from Western countries. Using a prospective longitudinal design, the current study examined demographic, clinical, behavioural and treatment programme predictors of gambling frequency at 3, 6 and 12-months, among PGs treated at an addiction clinic in Singapore. Measures included the Hospital anxiety and depression scale, gambling symptom assessment scale (GSAS), personal well-being index (PWI), treatment perception questionnaire and gambling readiness to change scale. Treatment response in relation to changes in symptom severity, personal wellbeing and abstinence were also assessed. Abstinence rates were 38.6, 46.0 and 44.4 % at 3, 6 and 12-months respectively. Significant reductions in gambling frequency, GSAS, and improvement in PWI were reported between baseline and subsequent outcome assessments, with the greatest change occurring in the initial three months. No demographic, clinical, behavioural or treatment programme variable consistently predicted outcome at all three assessments, though treatment satisfaction was the most frequent significant predictor. However, being unemployed, having larger than average debts, poor treatment satisfaction and attending fewer sessions at the later stages of treatment were associated with significantly poorer outcomes, up to 1-year after initiating treatment. These findings show promise for the effectiveness of a CBT-based treatment approach for the treatment of predominantly Chinese PGs. Clinical implications and suggestions for future research are discussed. Taken together, the findings suggest early treatment satisfaction is paramount in improving short-term outcomes, with baseline gambling behaviour and treatment intensity playing a more significant role in the longer term. PMID:22945784

  15. Pathology of flupirtine-induced liver injury: a histological and clinical study of six cases.

    Science.gov (United States)

    Puls, Florian; Agne, Clemens; Klein, Fritz; Koch, Martin; Rifai, Kinan; Manns, Michael P; Borlak, Jürgen; Kreipe, Hans H

    2011-06-01

    Drug-induced liver injury may cause impairment of liver function and is a leading cause of acute liver failure. Identification of the causative substance in patients receiving several drugs is often difficult in clinical practice. Evaluation of liver biopsies in suspected drug-induced injury is a challenging task that requires close clinico-pathological correlation. Recognizing a characteristic morphological pattern of liver injury may contribute to identification of the causative drug. Flupirtine, a non-opioid analgesic, has been reported to cause liver injury of idiosyncratic type in rare instances. We wished to characterize the histopathological features of flupirtine-induced liver injury, which have not been reported so far. Liver biopsies of five patients with severe liver injury and one explanted liver of a patient with flupirtine-induced acute liver failure that required transplantation were assessed. In addition clinical presentation and course were reviewed and clinical follow up was performed. Extensive perivenular necrosis with associated ceroid pigment-laden macrophages and a mild to moderate lymphocytic infiltrate was a common feature in all cases. Histological extent of liver necrosis corresponded well to serum amino-transferase levels. Accidental reexposure of one patient resulted in a plasma cell rich hepatitis with perivenular necrosis. This study provides evidence that flupirtine can cause substantial liver injury of hepatocellular type. Liver damage is associated with a characteristic morphological picture, the recognition of which will aid in causality assessment of drug-induced liver injury. Clinical and histological features raise the possibility of an immune-mediated toxicity. PMID:21590308

  16. Duodenal nodularity in children: A clinical and pathologic study of 17 cases

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    Çaltepe Dinler Gönül

    2011-01-01

    Full Text Available Aims: Duodenal nodularity is an uncommon endoscopic appearance of numerous visible mucosal nodules in the proximal duodenum. In this retrospective study we aimed to determine the clinical significance and histopathologic features of duodenal nodularity in children. Materials and Methods: The medical records of the patients who were defined to have duodenal nodularity by endoscopy were reviewed. Statistical Analysis Used: The data were expressed as mean ± SD and percentages (%. Results: Seventeen patients with endoscopically defined duodenal nodularity were chosen. The mean age at diagnosis was 12.1 years (range: 6-17 years, 9 males. Abdominal pain (47% was the most common clinical symptom and antral nodularity (41% was the most common endoscopic finding in children with duodenal nodularity. Histopathologic evaluation of duodenal nodules revealed chronic inflammation in all patients, increased intercryptal and intraepithelial numbers of eosinophils in 70.5%, and villous atrophy in 47% of patients. Giardia infestation was demonstrated in 6 patients by histologic examination and/or Giardia lamblia-specific antigen positivity in stools. The clinical diagnoses of the patients have shown variations, such as celiac disease, giardiasis, secretory IgA deficiency, and Helicobacter pylori gastritis, and some of them were associated with the others. Conclusions: Although the endoscopic appearance is similar, clinical spectrum and pathologic features are not so similar and there are no specific histomorphologic findings for nodularity. The most demonstrative findings we observed in children were increased lymphocyte and/or eosinophil infiltration in the duodenal mucosa. We suggested that care should be taken in the evaluation of microbiological and immunologic etiologies causing this prominent inflammatory reaction.

  17. Epidemiological, clinical, pathological, and therapeutic aspects of gastric cancer in Morocco

    Directory of Open Access Journals (Sweden)

    Sanna Elmajjaoui

    2014-01-01

    Full Text Available Purpose: Gastric cancer is a relatively frequent cancer and has poor prognosis. The present study is the first Moroccan study to investigate the epidemiological, clinical, pathological, therapeutic characteristics, and outcomes of gastric cancer. Materials and Methods: We conducted a retrospective study including 154 cases of gastric cancer treated at the National Institute of Oncology between January 2007 and December 2007. Results: The mean age at diagnosis was 55 years (18-87 years and the sex ratio was 2.14. Risk factors were dominated by tobacco use (30.5% and gastric ulcer (4.5%. The average interval between symptom presentation and consultation was 8.7 months (1-48 months. The clinical symptoms were dominated by epigastric pain (88.7%, vomiting (62.3%, and weight loss (80.5%. Oeso-gastric fibroscopy was performed in all patients and showed an ulcerated aspect in 77.9% of the cases. The location of the tumor was antropyloric in 42.2% of the cases. The most common histology was adenocarcinoma (72.8%, followed by non-Hodgkin lymphoma (22%, gastrointestinal stromal tumors (GIST; 3.2%, and neuroendocrine tumors (NET; 2%. Tumor stage was metastatic in 62% of the cases, locally advanced in 18.5% of the cases, and localized in only 8% of the cases; however, 11.5% of patients were not staged. Also, 46% of the patients with adenocarcinoma (n = 111 were not treated, 6.4% received chemotherapy first (non-resectable (one patient was operated, 20.6% received surgery first followed by adjuvant treatment, 4.5% received chemo-radiotherapy, 5.4% received chemotherapy only, and 27% received palliative chemotherapy. In the sub-group of patients diagnosed with non-Hodgkin lymphoma (n = 35, 48.5% received chemotherapy based on Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP regimen. In the sub-group diagnosed with GIST (n = 5 histology, all cases received surgery first and 2 cases received adjuvant chemotherapy based on doxorubicin. Finally

  18. Brain-derived neurotrophic factor expression predicts adverse pathological & clinical outcomes in human breast cancer

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    Mokbel Kefah

    2011-07-01

    Full Text Available Abstract Introduction Brain-derived neurotrophic factor (BDNF has established physiological roles in the development and function of the vertebrate nervous system. BDNF has also been implicated in several human malignancies, including breast cancer (BC. However, the precise biological role of BDNF and its utility as a novel biomarker have yet to be determined. The objective of this study was to determine the mRNA and protein expression of BDNF in a cohort of women with BC. Expression levels were compared with normal background tissues and evaluated against established pathological parameters and clinical outcome over a 10 year follow-up period. Methods BC tissues (n = 127 and normal tissues (n = 33 underwent RNA extraction and reverse transcription, BDNF transcript levels were determined using real-time quantitative PCR. BDNF protein expression in mammary tissues was assessed with standard immuno-histochemical methodology. Expression levels were analyzed against tumour size, grade, nodal involvement, TNM stage, Nottingham Prognostic Index (NPI and clinical outcome over a 10 year follow-up period. Results Immuno-histochemical staining revealed substantially greater BDNF expression within neoplastic cells, compared to normal mammary epithelial cells. Significantly higher mRNA transcript levels were found in the BC specimens compared to background tissues (p = 0.007. The expression of BDNF mRNA was demonstrated to increase with increasing NPI; NPI-1 vs. NPI-2 (p = 0.009. Increased BDNF transcript levels were found to be significantly associated with nodal positivity (p = 0.047. Compared to patients who remained disease free, higher BDNF expression was significantly associated with local recurrence (LR (p = 0.0014, death from BC (p = 0.018 and poor prognosis overall (p = 0.013. After a median follow up of 10 years, higher BDNF expression levels were significantly associated with reduced overall survival (OS (106 vs. 136 months, p = 0.006. BDNF

  19. Comprehensive clinical and pathological analysis of aggressive renal epithelioid angiomyolipoma: report of three cases

    Directory of Open Access Journals (Sweden)

    Luo J

    2014-05-01

    Full Text Available Jindan Luo,1 Ben Liu,1 Yanli Wang,2 Jun Li,2 Ping Wang,1 Jun Chen,1 Chaojun Wang1 1Department of Urology, 2Department of Pathology, The First Affiliated Hospital of College of Medicine, Zhejiang University, Zhejiang, People's Republic of China Abstract: Renal angiomyolipoma (AML is recognized as a benign hamartomatous lesion arising in the kidney with no obvious malignant potential. However, epithelioid AML (EAML, a rare variant of AML, is potentially malignant, with aggressive clinical features. It can occur in patients with or without tuberous sclerosis. Because EAML may mimic renal cell carcinoma in imaging studies, differentiation of this tumor from renal cell carcinoma preoperatively is difficult. At times, the lesions may extend into the renal vein and inferior vena cava or metastasize to other organs such as the lung and liver. To clarify the biological nature of EAML, three specific cases that we encountered in clinical practice are analyzed and reported in detail. Keywords: kidney, malignant, inferior vena cava

  20. Pathological and clinical correlates of FOXP3+ cells in renal allografts during acute rejection.

    Science.gov (United States)

    Veronese, F; Rotman, S; Smith, R N; Pelle, T D; Farrell, M L; Kawai, T; Benedict Cosimi, A; Colvin, R B

    2007-04-01

    The localization and significance of regulatory T cells (Treg) in allograft rejection is of considerable clinical and immunological interest. We analyzed 80 human renal transplant biopsies (including seven donor biopsies) with a double immunohistochemical marker for the Treg transcription factor FOXP3, combined with a second marker for CD4 or CD8. Quantitative FOXP3 cell counts were performed and analyzed for clinical and pathologic correlates. FOXP3(+) cells were present in the interstitium in acute cellular rejection (ACR) type I and II, at a greater density than in acute humoral rejection or CNI toxicity (p attraction or generation at that site. Considering only patients with ACR, a higher density of FOXP3(+) correlated with HLA class II match (p = 0.03), but paradoxically with worse graft survival. We conclude that infiltration of FOXP3(+) cells occurs in ACR to a greater degree than in humoral rejection, however, within the ACR group, no beneficial effect on outcome was evident. Tregs concentrate in tubules, probably contributing to FOXP3 mRNA in urine; the significance and pathogenesis of 'Treg tubulitis' remains to be determined. PMID:17286616

  1. Prostatic Artery Embolization (PAE) for Symptomatic Benign Prostatic Hyperplasia (BPH): Part 1, Pathological Background and Clinical Implications

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Fei, E-mail: feisun@ccmijesususon.com; Crisóstomo, Verónica, E-mail: crisosto@ccmijesususon.com; Báez-Díaz, Claudia, E-mail: cbaez@ccmijesususon.com; Sánchez, Francisco M., E-mail: msanchez@ccmijesususon.com [Jesús Usón Minimally Invasive Surgery Centre (Spain)

    2016-01-15

    Pathological features of benign prostatic hyperplasia (BPH) dictate various responses to prostatic artery embolization (PAE). Typically, BPH originates in the transition zone and periurethral region, where should be considered the primary target area in PAE procedures. Given that histological heterogeneity of components in hyperplasia nodules, epithelial or stromal, identifying the more responsive nodules to PAE will have clinical implications. Since some lower urinary tract symptoms (LUTS) in patients with BPH are usually related to bladder outlet obstruction-induced changes in bladder function rather than to outflow obstruction directly, proper selection of candidate patients prior to PAE is of great clinical importance. BPH is a typical chronic progressive condition, suggesting PAE could aim not only to relieve LUTS but also to delay or prevent the clinical progression. Awareness of the pathological background of BPH is essential for interventional radiologists to improve clinical outcomes and develop new treatment strategies in clinical practice of PAE.

  2. Prostatic Artery Embolization (PAE) for Symptomatic Benign Prostatic Hyperplasia (BPH): Part 1, Pathological Background and Clinical Implications

    International Nuclear Information System (INIS)

    Pathological features of benign prostatic hyperplasia (BPH) dictate various responses to prostatic artery embolization (PAE). Typically, BPH originates in the transition zone and periurethral region, where should be considered the primary target area in PAE procedures. Given that histological heterogeneity of components in hyperplasia nodules, epithelial or stromal, identifying the more responsive nodules to PAE will have clinical implications. Since some lower urinary tract symptoms (LUTS) in patients with BPH are usually related to bladder outlet obstruction-induced changes in bladder function rather than to outflow obstruction directly, proper selection of candidate patients prior to PAE is of great clinical importance. BPH is a typical chronic progressive condition, suggesting PAE could aim not only to relieve LUTS but also to delay or prevent the clinical progression. Awareness of the pathological background of BPH is essential for interventional radiologists to improve clinical outcomes and develop new treatment strategies in clinical practice of PAE

  3. Microinvasive ductal carcinoma in situ: Clinical presentation, imaging features, pathologic findings, and outcome

    International Nuclear Information System (INIS)

    Objective: The purpose of our study was to describe the clinical features, imaging characteristics, pathologic findings and outcome of microinvasive ductal carcinoma in situ (DCISM). Materials and methods: The records of 21 women diagnosed with microinvasive ductal carcinoma in situ (DCISM) from November 1993 to September 2006 were retrospectively reviewed. The clinical presentation, imaging and histopathologic features, and clinical follow-up were reviewed. Results: The 21 lesions all occurred in women with a mean age of 56 years (range, 27-79 years). Clinical findings were present in ten (48%): 10 with palpable masses, four with associated nipple discharge. Mean lesion size was 21 mm (range, 9-65 mm). The lesion size in 62% was 15 mm or smaller. Mammographic findings were calcifications only in nine (43%) and an associated or other finding in nine (43%) [mass (n = 7), asymmetry (n = 1), architectural distortion (n = 1)]. Three lesions were mammographically occult. Sonographic findings available in 11 lesions showed a solid hypoechoic mass in 10 cases (eight irregular in shape, one round, one oval). One lesion was not seen on sonography. On histopathologic examination, all lesions were diagnosed as DCISM, with a focus of invasive carcinoma less than or equal to 1 mm in diameter within an area of DCIS. Sixteen (76%) lesions were high nuclear grade, four (19%) were intermediate and one was low grade (5%). Sixteen (76%) had the presence of necrosis. Positivity for ER and PR was noted in 75% and 38%. Nodal metastasis was present in one case with axillary lymph node dissection. Mean follow-up time for 16 women was 36 months without evidence of local or systemic recurrence. One patient developed a second primary in the contralateral breast 3 years later. Conclusion: The clinical presentation and radiologic appearance of a mass are commonly encountered in DCISM lesions (48% and 57%, respectively), irrespective of lesion size, mimicking findings seen in invasive carcinoma

  4. Microinvasive ductal carcinoma in situ: Clinical presentation, imaging features, pathologic findings, and outcome

    Energy Technology Data Exchange (ETDEWEB)

    Vieira, Cristina C. [Department of Radiology, New York University School of Medicine (United States); Mercado, Cecilia L. [Department of Radiology, New York University School of Medicine (United States)], E-mail: Cecilia.mercado@nyumc.org; Cangiarella, Joan F. [Department of Pathology, New York University School of Medicine (United States); Moy, Linda; Toth, Hildegard K. [Department of Radiology, New York University School of Medicine (United States); Guth, Amber A. [Department of Surgery, New York University School of Medicine (United States)

    2010-01-15

    Objective: The purpose of our study was to describe the clinical features, imaging characteristics, pathologic findings and outcome of microinvasive ductal carcinoma in situ (DCISM). Materials and methods: The records of 21 women diagnosed with microinvasive ductal carcinoma in situ (DCISM) from November 1993 to September 2006 were retrospectively reviewed. The clinical presentation, imaging and histopathologic features, and clinical follow-up were reviewed. Results: The 21 lesions all occurred in women with a mean age of 56 years (range, 27-79 years). Clinical findings were present in ten (48%): 10 with palpable masses, four with associated nipple discharge. Mean lesion size was 21 mm (range, 9-65 mm). The lesion size in 62% was 15 mm or smaller. Mammographic findings were calcifications only in nine (43%) and an associated or other finding in nine (43%) [mass (n = 7), asymmetry (n = 1), architectural distortion (n = 1)]. Three lesions were mammographically occult. Sonographic findings available in 11 lesions showed a solid hypoechoic mass in 10 cases (eight irregular in shape, one round, one oval). One lesion was not seen on sonography. On histopathologic examination, all lesions were diagnosed as DCISM, with a focus of invasive carcinoma less than or equal to 1 mm in diameter within an area of DCIS. Sixteen (76%) lesions were high nuclear grade, four (19%) were intermediate and one was low grade (5%). Sixteen (76%) had the presence of necrosis. Positivity for ER and PR was noted in 75% and 38%. Nodal metastasis was present in one case with axillary lymph node dissection. Mean follow-up time for 16 women was 36 months without evidence of local or systemic recurrence. One patient developed a second primary in the contralateral breast 3 years later. Conclusion: The clinical presentation and radiologic appearance of a mass are commonly encountered in DCISM lesions (48% and 57%, respectively), irrespective of lesion size, mimicking findings seen in invasive carcinoma

  5. Rectal gastrointestinal stromal tumors: Imaging features with clinical and pathological correlation

    Directory of Open Access Journals (Sweden)

    Zhao-Xia Jiang

    2013-01-01

    Full Text Available AIM: To investigate computed tomography (CT and magnetic resonance imaging (MRI manifestations of rectal gastrointestinal stromal tumors (GISTs in order to enhance the recognition of these rare tumors. METHODS: Fourteen patients with pathologically proven rectal GISTs were retrospectively reviewed. Patient histories were retrospectively reviewed for patient age, gender, presenting symptoms, endoscopic investigations, operation notes and pathologic slides. All tumors were evaluated for CD117, CD34 expression, and the tumors were stratified according to current criteria of the National Institutes of Health (NIH. In all cases the first pre-operation imaging findings (CT and MRI, n = 3; MRI only, n = 8; CT only, n = 3 were analyzed by two experienced radiologists by consensus, which include: tumor size, shape, CT density (hypodense, isodense and hyperdense, MRI signal intensity (hypointense, isointense and hyperintense, epicenter (intraluminal or extraluminal, margin (well-defined or ill-defined, internal component (presence of calcifications, necrosis, hemorrhage or ulceration, pattern and degree of enhancement, invasion into adjacent structures. After review of the radiologic studies, clinical and pathological findings were correlated with radiological findings. RESULTS: The patients, 13 men and 1 woman, were aged 31-62 years (mean = 51.5 ± 10.7 years. The most common initial presentation was hematochezia (n = 6. The mean tumor diameter was 5.68 ± 2.64 cm (range 1.5-11.2 cm. Eight lesions were round or oval, and 6 lesions were irregular. Eleven lesions were well-defined and 3 had ill-defined margins. Ten tumors were extraluminal and 4 were intraluminal. The density and MR signal intensity of the solid component of the lesions were similar to that of muscle on unenhanced CT (n = 6 and T1-weighted images (n = 11, and hyperintense on T2-weighted MR images. Calcification was detected in 2 tumors. Following intravenous injection of contrast media, 3

  6. Retrospective analysis of clinical pathological findings in obstruction of lower urinary pathways in cats

    Directory of Open Access Journals (Sweden)

    Francuski Jelena

    2013-01-01

    Full Text Available Diseases of the lower urinary pathways with urethral obstruction are frequent urological conditions demanding urgent treatment that lead to the occurrence of post renal azotemia due to difficult or disabled urine elimination. The aim of these investigations was to establish the most frequent causes for the occurrence of obstructions of the lower urinary pathways in cats, the most frequent clinical signs, as well as the changes in the hematological and biochemical blood and urine parameters. The obtained results indicate that the most frequent cause of urethral obstruction in cats is the presence of urethra stones, sand, and urethra plugs caused by the aggregation of struvite crystals on organic matrix. The laboratory findings showed that all animals were dehydrated, azotemia was established in half the animals, and signs of uremia were evident in 10% cats. Over 90% cats had disrupted tubular function, and only 50% had clear laboratory signs of inflammation. It can be concluded from the presented results that all cats with urethra obstruction exhibit a certain degree of disrupted kidney function, which is, in most cases, a reversible pathological change when treated with timely and adequate therapy. [Projekat Ministarstva nauke Republike Srbije, br. 175061

  7. Clinical, laboratory and pathological findings in sub-acute monensin intoxication in goats.

    Science.gov (United States)

    Deljou, Mahdi; Aslani, Mohammad Reza; Mohri, Mehrdad; Movassaghi, Ahmad Reza; Heidarpour, Mohammad

    2014-01-01

    Toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. The present study was performed to investigate the toxic effects of monensin in goats. Seven adult goats were administered sodium monensin, 13.5 mg kg(-1), daily for five consecutive days via gastric gavage. Monensin toxicity was evaluated by clinical signs, serum biochemistry and pathology. Monensin exposure caused diarrhea, tachycardia and reduction in ruminal movements and body temperature. Significant increase of creatine kinase, lactate dehydrogenase, aspartate aminotransferase, total bilirubin, blood urea nitrogen, creatinine and erythrocyte superoxide dismutase were observed in monensin exposed goats. Reduction of erythrocyte glutathione peroxidase and elevation of serum malondialdehyde and troponin I were inconsistent. In necropsy, there were effusions in body cavities, vacuolar degeneration and coagulative necrosis in cardiac and skeletal muscles and renal tubular necrosis. These findings suggested that monensin intoxication in goats leads to cardiac, skeletal and renal damage and a wide range of biochemical abnormalities. Oxidative stress may be involved in the pathogenesis of monensin poisoning. PMID:25568713

  8. Managing chronic pathologies with a stepped mHealth-based approach in clinical psychology and medicine

    Directory of Open Access Journals (Sweden)

    Gianluca Castelnuovo

    2015-04-01

    Full Text Available Chronic diseases and conditions typically require long-term monitoring and treatment protocols both in traditional settings and in out-patient frameworks. The economic burden of chronic conditions is a key challenge and new and mobile technologies could offer good solutions. mHealth could be considered an evolution of ehealth and could be defined as the practice of medicine and public health supported by mobile communication devices. mHealth approach could overcome limitations linked with the traditional, restricted and highly expensive in-patient treatment of many chronic pathologies. Possible applications include stepped mHealth approach, where patients can be monitored and treated in their everyday contexts. Unfortunately, many barriers for the spread of mHealth are still present. Due the significant impact of psychosocial factors on disease evolution, psychotherapies have to be included into the chronic disease protocols. Existing psychological theories of health behavior change have to be adapted to the new technological contexts and requirements. In conclusion, clinical psychology and medicine have to face the chronic care management challenge in both traditional and mHealth settings.

  9. Hepatocellular carcinoma (HCC) in non-cirrhotic liver: clinical, radiological and pathological findings

    Energy Technology Data Exchange (ETDEWEB)

    Di Martino, Michele; Di Miscio, Rossella; Lombardo, Concetta Valentina; Catalano, Carlo [University of Rome ' ' Sapienza' ' , Department of Radiological Sciences, Oncology and Anatomical Pathology, Rome (Italy); Saba, Luca; Piga, Mario [Department of Radiology Azienda Ospedaliera Universitaria (A.O.U.), Monserrato (Italy); Bosco, Sandro [University of Rome ' ' Sapienza' ' , Department of Molecular Medicine, Rome (Italy); Rossi, Massimo [University of Rome ' ' Sapienza' ' , Department of General Surgery, Division of Organ Transplantation, Rome (Italy); Miles, Kirchin A. [Worldwide Medical and Regulatory Affairs, Milan (Italy); Tamponi, Elisabetta [Azienda Ospedaliera Universitaria (A.O.U.), Department of Anatomical Pathology, Monserrato (Italy)

    2014-07-15

    Our aim was to evaluate the clinical and pathological findings, mutidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI) appearances, treatment and 1-year survival of patients with HCC in non-cirrhotic liver. Histopathological and laboratory findings of 30 non-cirrhotic patients with 32 HCCs were reviewed retrospectively. MDCT and gadobenate dimeglumine-enhanced MR images were evaluated in consensus by two radiologists in terms of HCC size, presence of tumour capsule, necrosis, haemorrhage, fat and calcification, and vascular involvement. Imaging patterns were compared directly with HCC findings in a matched group of cirrhotic patients. No differences between non-cirrhotic and cirrhotic patients were noted in terms of serum α-fetoprotein levels (elevated in 11 [36.7 %] and 21 [35 %] patients, respectively). The imaging appearance at CT and contrast-enhanced MRI was typical in 27 (84.3 %) and 28 (87.5 %) cases respectively. Most lesions presented as a well-differentiated large solitary mass, with well-defined margins, areas of necrosis and peripheral capsule. No significant differences in HCC pattern were observed between cirrhotic and non-cirrhotic liver. In non-cirrhotic patients, HCC is more likely to manifest as an asymptomatic mass with elevation of serum tumour markers similar to that seen in cirrhotic patients. HCC in cirrhotic and non-cirrhotic livers show similar enhancement patterns. (orig.)

  10. Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management

    Directory of Open Access Journals (Sweden)

    Teixeira Mendes LS

    2014-07-01

    Full Text Available Larissa Sena Teixeira Mendes,1 Ming-Qing Du,2 Estella Matutes,3 Andrew Wotherspoon11Histopathology Department, Royal Marsden Hospital, London, UK; 2Molecular Malignancy Laboratory and Department of Histopathology, University Hospital NHS Foundation Trust/Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK; 3Hematopathology Unit, Hospital Clinic, Barcelona University, Barcelona, Spain Abstract: Splenic marginal zone lymphoma is a distinct low grade B-cell lymphoma primarily occurring in the spleen and separate from nodal marginal zone lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. It is characterized by a relative indolent course, splenomegaly, moderate lymphocytosis, and an intrasinusoidal pattern of involvement, especially in the bone marrow. It is postulated that the neoplastic clone originates from persistent antigenic stimulation of marginal zone B-cells. Molecular and cytogenetic studies have failed to show specific alterations. There is no standard criterion to initiate treatment, which may include a watch and wait policy, splenectomy, or chemo/immunotherapy. This review highlights the main features of this entity, reassessing the guidelines for diagnosis, prognostic factors, staging, and management published by the SMZL Working Group (2008. Keywords: splenectomy, villous lymphocytes, guidelines

  11. Hepatocellular carcinoma (HCC) in non-cirrhotic liver: clinical, radiological and pathological findings

    International Nuclear Information System (INIS)

    Our aim was to evaluate the clinical and pathological findings, mutidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI) appearances, treatment and 1-year survival of patients with HCC in non-cirrhotic liver. Histopathological and laboratory findings of 30 non-cirrhotic patients with 32 HCCs were reviewed retrospectively. MDCT and gadobenate dimeglumine-enhanced MR images were evaluated in consensus by two radiologists in terms of HCC size, presence of tumour capsule, necrosis, haemorrhage, fat and calcification, and vascular involvement. Imaging patterns were compared directly with HCC findings in a matched group of cirrhotic patients. No differences between non-cirrhotic and cirrhotic patients were noted in terms of serum α-fetoprotein levels (elevated in 11 [36.7 %] and 21 [35 %] patients, respectively). The imaging appearance at CT and contrast-enhanced MRI was typical in 27 (84.3 %) and 28 (87.5 %) cases respectively. Most lesions presented as a well-differentiated large solitary mass, with well-defined margins, areas of necrosis and peripheral capsule. No significant differences in HCC pattern were observed between cirrhotic and non-cirrhotic liver. In non-cirrhotic patients, HCC is more likely to manifest as an asymptomatic mass with elevation of serum tumour markers similar to that seen in cirrhotic patients. HCC in cirrhotic and non-cirrhotic livers show similar enhancement patterns. (orig.)

  12. Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings.

    Science.gov (United States)

    Mizukami, Keijiro; Shoubudani, Tomoaki; Nishimoto, Seira; Kawamura, Ryuta; Yabuki, Akira; Yamato, Osamu

    2012-06-01

    Trapped neutrophil syndrome (TNS) is an autosomal recessive inherited neutropenia known in Border Collies since the 1990's. Recently, the causative mutation has been identified in the canine VPS13B gene and a DNA-based diagnosis has now become available. The present paper describes clinical and clinico-pathologic findings in a Border Collie with TNS that was molecularly diagnosed for the first time in Japan. In a 10-week-old male Border Collie with microgenesis and symptoms related to recurrent infections, a hematological examination revealed severe leukopenia due to neutropenia, suggesting the dog to be affected by inherited neutropenic immunodeficiency. Direct DNA sequencing demonstrated that the dog was homozygous for the causative mutation of TNS and both its parents were heterozygous carriers. In addition, a simple and rapid polymerase chain reaction-based length polymorphism analysis coupled with microchip electrophoresis was developed for the genotyping of TNS. This assay could discriminate clearly all genotypes, suggesting that it was suitable for both individual diagnosis and large-scale surveys for prevention. PMID:22240985

  13. Existing data sources for clinical epidemiology: the Danish National Pathology Registry and Data Bank

    DEFF Research Database (Denmark)

    Erichsen, Rune; Lash, Timothy; Dutoit, Stephen Jacques Hamilton;

    2010-01-01

    epidemiological research. We describe two recent additions to these databases: the Danish National Pathology Registry (DNPR) and its underlying national online registration database, the Danish Pathology Data Bank (DPDB). The DNPR and the DPDB contain detailed nationwide records of all pathology specimens...... analyzed in Denmark since 1997, and an incomplete but nonetheless valuable record of specimens from some pathology departments dating back to the 1970s. The data are of high quality and completeness and are sufficient to allow precise and efficient localization of the specimens. We describe the relatively...

  14. Performance of speech-language pathology students in problem-based learning tutorials and in clinical practice.

    Science.gov (United States)

    Ho, Diana W L; Whitehill, Tara L; Ciocca, Valter

    2014-01-01

    The purpose of the study was to identify if performance of speech-language pathology students in problem-based learning (PBL) tutorials could predict subsequent clinical performance evaluated through (a) a non-standardized, custom clinical evaluation form (HKU form) and (b) a standardized competency assessment for speech pathology developed in Australia (COMPASS®). Students' scores from PBL tutorial performance were correlated with scores in clinical placement on both the HKU form and the COMPASS. Significant correlations were found between students' PBL tutorial performance (reflective journals and participation in the tutorial process) and their clinical performance (treatment and interpersonal skills) on the HKU clinical evaluation form. Significant correlations were also found between (a) PBL tutorial performance (participation in the tutorial process) and their clinical performance (all generic and occupational competencies, and the overall score) on the COMPASS, (b) PBL tutorial performance (reading forms) and two occupational competencies on the COMPASS, (c) PBL tutorial performance (reflective journals) and four occupational competencies and the overall score on the COMPASS. The results highlighted the need for validating the assessment for the learning process in PBL tutorials with empirical evidence and the advantage of assessing clinical performance through COMPASS in Hong Kong. Tutors, clinical supervisors and students should be given clear behavioral descriptors for expected performance in PBL tutorials and clinical practice at different year levels. PMID:23889172

  15. Clinical and pathological implications of miRNA in bladder cancer

    Directory of Open Access Journals (Sweden)

    Braicu C

    2015-01-01

    Full Text Available Cornelia Braicu,1 Roxana Cojocneanu-Petric,1,2 Sergiu Chira,1 Anamaria Truta,1,3 Alexandru Floares,4 Bogdan Petrut,5,6 Patriciu Achimas-Cadariu,7,8,* Ioana Berindan-Neagoe1,9–11,*1Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 2Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania; 3Department of Medical Genetics, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 4Solutions of Artificial Intelligence Applications, Cluj-Napoca, Romania; 5Department of Urology, The Oncology Institute “ Prof Dr. Ion Chiricuta”, Cluj-Napoca, Romania; 6Department of Urology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 7Department of Surgery, The Oncology Institute “ Prof Dr. Ion Chiricuta”, Cluj-Napoca, Romania; 8Department of Surgical Oncology and Gynaecological Oncology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 9Department of Immunology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; 10Department of Functional Genomics and Experimental Pathology, The Oncology Institute “ Prof Dr. Ion Chiricuta”, Cluj-Napoca, Romania; 11Department of Experimental Therapeutics M.D. Anderson Cancer Center Houston, TX, USAAbstract: MicroRNAs (miRNAs are small, noncoding RNA species with a length of 20–22 nucleotides that are recognized as essential regulators of relevant molecular mechanisms, including carcinogenesis. Current investigations show that miRNAs are detectable not only in different tissue types but also in a wide range of biological fluids, either free or trapped in circulating microvesicles. miRNAs were proven to be involved in cell communication, both in pathological and physiological processes. Evaluation of the global expression patterns of miRNAs provides key opportunities with

  16. Clinical Manifestations of pathology of temporomandibular joints and masticatory muscles in patients with teeth occlusion and teeth row disturbances

    Directory of Open Access Journals (Sweden)

    A.V. Lepilin

    2010-06-01

    Full Text Available The aim of the research is a literature review about the problem of temporomandibular joints and masticatory muscles in patients with teeth occlusion and teeth row disturbances. Teeth occlusion and teeth row disturbances are widespread pathology of maxillofacial area, that can lead to different pathology alterations of masticatory system including musculo-articular dysfunction. Some specialists consider that the key factor of pathogenesis of musculo-articular dysfunction is occlusion disturbances, by the other opinion - discoordination of muscle contraction. Thus occlusive and muscular disorders are leading in pathogenesis and clinic of musculo-articular dysfunction

  17. Adjuvant radiotherapy for pathologically advanced prostate cancer a randomized clinical trial

    Energy Technology Data Exchange (ETDEWEB)

    Ian, M.; Thompson, J.R.; Catherine, M.; Tangen, P.H.; Paradelo, J.; Scott Lucia, M.; Miller, G.; Troyer, D.; Messing, E.; Forman, J.; Chin, J.; Swanson, G.; Canby-Hagino, E.; Crawford, E.D

    2008-01-15

    Context - Despite a stage-shift to earlier cancer stages and lower tumor volumes for prostate cancer, pathologically advanced disease is detected at radical prostatectomy in 38% to 52% of patients. However, the optimal management of these patients after radical prostatectomy is unknown. Objective - To determine whether adjuvant radiotherapy improves metastasis-free survival in patients with stage pT3 NO MO prostate cancer. Design, Setting, and Patients - Randomized, prospective, multi-institutional, US clinical trial with enrollment between August 15, 1988, and January 1, 1997 (with database frozen for statistical analysis on September 21, 2005). Patients were 425 men with pathologically advanced prostate cancer who had undergone radical prostatectomy. Intervention - Men were randomly assigned to receive 60 to 64 Gy of external beam radiotherapy delivered to the prostatic fossa (n = 214) or usual care plus observation (n = 211). Main Outcome Measures - Primary outcome was metastasis-free survival, defined as time to first occurrence of metastatic disease or death due to any cause. Secondary outcomes included prostate-specific antigen (PSA) relapse, recurrence-free survival, overall survival, freedom from hormonal therapy, and postoperative complications. Results - Among the 425 men, median follow-up was 10.6 years (inter-quartile range, 9.2-12.7 years). For metastasis-free survival,76 (35.5%) of 214 men in the adjuvant radiotherapy group were diagnosed with metastatic disease or died (median metastasis-free estimate, 14.7 years), compared with 91 (43.1%) of 211 (median metastasis-free estimate, 13.2 years) of those in the observation group (hazard ratio [HR], 0.75; 95% CI, 0.55-1.02; P = .06). There were no significant between-group differences for overall survival (71 deaths, median survival of 14.7 years for radiotherapy vs 83 deaths, median survival of 13.8 years for observation; HR, 0.80; 95% Cl, 0.58-1.09; P =.16). PSA relapse (median PSA relapse-free survival

  18. Adnexal torsion: clinical, radiological and pathological characteristics in a tertiary care centre in Southern India

    Directory of Open Access Journals (Sweden)

    Swapna Mohan

    2014-06-01

    Methods: Observational study was carried out from January 2006 to June 2014. Medical records of 38 cases of adnexal torsion were selected and analyzed retrospectively for age, parity, risk factors, clinical presentation, presence of leukocytosis, gray scale ultrasound and colour Doppler features, management, pathological results and post-operative outcome. Results: Adnexal torsion occurred most commonly in reproductive age group (mean 27.89 years of whom 3 were pregnant. 42% had known risk factors commonly prior pelvic surgery (52.63% and prior tubal ligation (31.58%. Symptoms include sudden abdominal or pelvic pain (94.74%, vomiting (60.53% and fever (21.05%. Gray scale USG showed mixed echogenic mass (36.84%, homogenously echogenic cyst (34.21% anechoic cyst (26.32% and free fluid (23.68%. Doppler showed absent arterial and venous flow in 52.63%. Cases were managed by detorsion and cystectomy (42.11%, unilateral salpingooophorectomy (47.37%, bilateral salpingooophorectomy (5.26% and TAH with BSO (5.26%. Histopathology revealed benign serous epithelial tumors (31.58%, mucinous tumors (21.05%, mature teratoma (10.53%, corpus luteal cyst (5.26%, follicular cyst (2.63% paraovarian cyst (13.16%, endometriotic cyst (2.63% and ovarian hemangioma (2.63%. Conclusions: High index of suspicion and prompt surgical intervention is necessary to preserve ovarian function even if Doppler shows vascularity. Though detorsion and cystectomy is the choice, salpingooophorectomy may be needed in infracted ovaries and older women. Higher incidence of serous and mucinous tumors in our study suggests reappraisal of ovary sparing surgery for all patients as advocated by few. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 703-708

  19. Behavioral, clinical, and pathological characterization of acid metalliferous water toxicity in mallards.

    Science.gov (United States)

    Isanhart, John P; Wu, Hongmei; Pandher, Karamjeet; MacRae, Russell K; Cox, Stephen B; Hooper, Michael J

    2011-11-01

    From September to November 2000, United States Fish and Wildlife Service biologists investigated incidents involving 221 bird deaths at 3 mine sites located in New Mexico and Arizona. These bird deaths primarily involved passerine and waterfowl species and were assumed to be linked to consumption of acid metalliferous water (AMW). Because all of the carcasses were found in or near pregnant leach solution ponds, tailings ponds, and associated lakes or storm water retention basins, an acute-toxicity study was undertaken using a synthetic AMW (SAMW) formulation based on the contaminant profile of a representative pond believed to be responsible for avian mortalities. An acute oral-toxicity trial was performed with a mixed-sex group of mallards (Anas platyrhynchos). After a 24-h pretreatment food and water fast, gorge drinking was evident in both SAMW treatment and control groups, with water consumption rates greatest during the initial drinking periods. Seven of nine treated mallards were killed in extremis within 12 h after the initiation of dose. Total lethal doses of SAMW ranged from 69.8 to 270.1 mL/kg (mean ± SE 127.9 ± 27.1). Lethal doses of SAMW were consumed in as few as 20 to 40 min after first exposure. Clinical signs of SAMW toxicity included increased serum uric acid, aspartate aminotransferase, creatine kinase, potassium, and P levels. PCV values of SAMW-treated birds were also increased compared with control mallards. Histopathological lesions were observed in the esophagus, proventriculus, ventriculus, and duodenum of SAMW-treated mallards, with the most distinctive being erosion and ulceration of the kaolin of the ventriculus, ventricular hemorrhage and/or congestion, and duodenal hemorrhage. Clinical, pathological, and tissue-residue results from this study are consistent with literature documenting acute metal toxicosis, especially copper (Cu), in avian species and provide useful diagnostic profiles for AMW toxicity or mortality events. Blood and

  20. Nuclear microprobe analysis of muscle biopsies: Applications in pathology and clinic

    International Nuclear Information System (INIS)

    The nuclear microprobe analysis of muscle biopsy sections has been recently applied to investigate different muscle disorders. This technique, employed as a complementary examination in the frame of pathological studies, permitted to confirm the diagnosis for a first pathology and to elucidate the cause of a second. In skeletal muscles of a young patient suffering from a slow progressive myopathy, calcium accumulations have been demonstrated in histologically abnormal fibers. These findings have been compared to histopathological characteristics previously described. On the other hand, we have evaluated muscle sections from two patients who presented symptoms of an inflammatory myopathy, a rare pathology that recently emerged in France. The chemical analyses permitted us to highlight local aluminium infiltration in muscles. The hypothesis of an unusual reaction to intramuscular aluminium accumulation has been advanced. These studies demonstrate the capability for ion beam microanalytical techniques to address acute problems in pathology

  1. International Clinical Guidelines for the Adoption of Digital Pathology: A Review of Technical Aspects.

    Science.gov (United States)

    García-Rojo, Marcial

    2016-01-01

    Digital slides, also called whole-slide images, are being evaluated to replace conventional microscopy, and several guidelines have been published. This paper reviews technical specifications of digital pathology systems that have been included in the guidelines and position papers from the Canadian Association of Pathologists, the College of American Pathologists, the American Telemedicine Association, the Digital Pathology Association, the Food and Drug Administration, the Centers for Medicare and Medicaid Services, the Centers for Disease Control and Prevention, the Society of Toxicologic Pathology, the European Commission, the Spanish Society of Anatomic Pathology, The Royal College of Pathologists and The Royal College of Pathologists of Australasia. In conclusion, most technical aspects are well covered by these guidelines, although they offer limited information regarding image quality and compression, and file formats. PMID:27100834

  2. Existing data sources for clinical epidemiology: the Danish National Pathology Registry and Data Bank

    DEFF Research Database (Denmark)

    Erichsen, Rune; Lash, Timothy; Dutoit, Stephen Jacques Hamilton;

    2010-01-01

    epidemiological studies to be carried out. Such studies are of significant importance, for example in the search for novel prognostic and predictive biomarkers in the era of personalized medicine. Denmark has a wealth of highly-regarded population-based registries that are ideally suited to conduct this type of......Diagnostic histological and cytological specimens are routinely stored in pathology department archives. These biobanks are a valuable research resource for many diseases, particularly if they can be linked to high quality population-based health registries, allowing large retrospective...... epidemiological research. We describe two recent additions to these databases: the Danish National Pathology Registry (DNPR) and its underlying national online registration database, the Danish Pathology Data Bank (DPDB). The DNPR and the DPDB contain detailed nationwide records of all pathology specimens...

  3. Clinical and pathological manifestations of cardiovascular disease in rat models: the influence of acute ozone exposure

    Science.gov (United States)

    This paper shows that rat models of cardiovascular diseases have differential degrees of underlying pathologies at a young age. Rodent models of cardiovascular diseases (CVD) and metabolic disorders are used for examining susceptibility variations to environmental exposures. How...

  4. Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications

    OpenAIRE

    Prashant Mathur; Priyanka Jain; Sandeep Kumar Mathur

    2011-01-01

    Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy. Microarray is a powerful technique of assessment of gene function by measuring transcription of large...

  5. Investigation of correlation between colonic cancer related anemia and characteristics of clinical pathology

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Objective To investigate the correlation between colonic cancer-related anemia and the pathologic features of colonic cancer.Methods The relationship between colonic cancer-related anemia and the pathologic features of colonic cancer was analyzed in a statistical method.Results There was no statistical significance between the histopathological type and incidence of colonic cancer-related anemia(P>0.05).There was statistical significance between the general classification of colonic cancer

  6. Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies

    International Nuclear Information System (INIS)

    [123I] Meta-iodobenzylguanidine (MIBG) myocardial scintigraphy has been used to evaluate postganglionic cardiac sympathetic innervation in heart diseases and some neurological disorders. To see clinical usefulness of MIBG myocardial scintigraphy to differentiate Parkinson's disease (PD) and dementia with Lewy bodies (DLB) from related movement disorders and Alzheimer disease (AD), we performed MIBG myocardial scintigraphy in patients with these disorders. Cardiac uptake of MIBG is specifically reduced in PD and DLB, and this imaging approach is a sensitive diagnostic tool that possibly differentiates PD and DLB from related movement disorders and AD. To see pathological basis of the reduced cardiac uptake of MIBG in Lewy body disease, we immunohistichemically examined cardiac tissues from patients with PD, DLB, related movement disorders and AD using antibodies against tyrosine hydroxylase (TH) and phosphorylated neurofilament (NF). Not only TH- but also NF-immunoreactive (ir) axons in the epicardial nerve fascicles were markedly decreased in Lewy body disease, namely cardiac sympathetic denervation, which accounts for the reduced cardiac uptake of MIBG in Lewy body disease. Patients with PD and DLB have Lewy bodies (LBs) in the nervous system, whereas patients with multiple system atrophy (MSA), progressive supranuclear palsy, corticobasal degeneration, parkin-associated PD and AD have no LBs in the nervous system. Even in patients with MSA, cardiac sympathetic denervation was associated with the presence of LBs. Therefore, cardiac sympathetic denervation is closely related to the presence of LBs in a wide range of neurodegenerative processes. Taken together, we conclude that the reduced cardiac uptake of MIBG is a potential biomarker for the presence of LBs. Because α-synuclein is one of the key molecules in the pathogenesis of PD, we further investigate how α-synuclein aggregates are involved in degeneration of the cardiac sympathetic nerve in PD. We

  7. Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention.

    Science.gov (United States)

    Smolensky, Michael H; Hermida, Ramon C; Reinberg, Alain; Sackett-Lundeen, Linda; Portaluppi, Francesco

    2016-01-01

    pressure 24 h patterns (nocturnal hypertension); delayed sleep phase syndrome, non-24 h sleep/wake disorder; recurrent hypersomnia; SW intolerance; delirium; peptic ulcer disease; kidney failure; depression; mania; bipolar disorder; Parkinson's disease; Smith-Magenis syndrome; fatal familial insomnia syndrome; autism spectrum disorder; asthma; byssinosis; cancers; hand, foot and mouth disease; post-operative state; and ICU outcome. Poorly conceived medical interventions, for example nighttime dosing of synthetic corticosteroids and certain β-antagonists and cyclic nocturnal enteral or parenteral nutrition, plus lifestyle habits, including atypical eating times and chronic alcohol consumption, also can be causal of CD. Just as surprisingly are the many proven chronotherapeutic strategies available today to manage the CD of several of these medical conditions. In clinical medicine, CD seems to be a common, yet mostly unrecognized, pathologic mechanism of human disease as are the many effective chronotherapeutic interventions to remedy it. PMID:27308960

  8. Clinical, Radiographic, and Pathologic Findings in Patients Undergoing Reoperation Following Radiation Therapy and Temozolomide for Newly Diagnosed Glioblastoma

    Science.gov (United States)

    Ellsworth, Susannah; Ye, Xiaobu; Grossman, Stuart A.

    2016-01-01

    Purpose Patients with glioblastoma (GBM) frequently deteriorate clinically and radiographically after chemoradiation and may require repeat surgical intervention. We attempted to correlate pathologic findings with preoperative clinical characteristics and survival in patients undergoing reoperation for GBM. Materials and Methods Patients eligible for this retrospective analysis had pathologically confirmed GBM diagnosed between 2005 and 2010, received standard radiation and temozolomide, and underwent repeat resection within 18 months of diagnosis. Results Thirty-eight patients were identified. Median age was 56 years (range, 30 to 80 y), 55% were male, and 66% had baseline performance status ≥90%. Median survival was 16.3 months (95% confidence interval [CI], 13.3–19.8) from initial surgery. At reoperation, 21% of patients had no pathologically evident tumor. Median time from initial diagnosis to second surgery was similar in patients with and without evident tumor (8.5 vs. 8.8 mo, respectively). Patients without evident tumor tended to have a worse performance status. Median overall survival from second surgery was 7 months (95% CI, 4.2–10.1) and 9.1 months (95% CI, 2.1–25.3) for patients with and without evident tumor, respectively. Multivariate proportional hazards analysis showed a hazard ratio for death of 0.61 (95% CI, 0.25–1.49) for patients without evident tumor after adjusting for Karnofsky performance status and second surgical procedure. Conclusions GBM patients with and without disease recurrence have similar clinical characteristics at the time of second surgical resection. Pathologic outcomes were not correlated with specific clinical or radiologic characteristics, including the time from diagnosis to reoperation. There was a trend toward improved overall survival among patients without evident tumor at reoperation. PMID:26491903

  9. Postsurgical Pathologies Associated with Intradural Electrical Stimulation in the Central Nervous System: Design Implications for a New Clinical Device

    OpenAIRE

    2014-01-01

    Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk of certain postsurgical complications, it became exclusively epidural eventually. Here we review the relevant clinical and experimental pathologic findings, including spinal cor...

  10. DEVELOPMENT OF THE NOMOGRAM THAT PREDICTS PATHOLOGICAL LYMPH NODE INVOLVEMENT IN BLADDER CANCER PATIENTS BASED ON CLINICAL VARIABLES

    OpenAIRE

    L. V. Mirylenko; O. G. Sukonko; A. V. Pravorov; A. I. Rolevich; A. S. Mavrichev

    2014-01-01

    Objective: to develop nomogram based on clinical variables, that predicts pathological lymph node involvement (рN+) in bladder cancer patients.Material and methods: We used data of 511 patients with bladder cancer, that have undergone radical cystectomy between 1999 and 2008 at N.N. Alexandrov National Cancer Centre. Mono- and multivariate logistic regression analyses were used for pN+ prediction on preoperative data. Coefficients from logistic regression equation were used to construct the n...

  11. Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model

    Directory of Open Access Journals (Sweden)

    Terelius Ylva

    2008-11-01

    Full Text Available Abstract Background This study was performed to characterize a gene-addition transgenic mouse containing a BAC (bacterial artificial chromosome clone spanning the human CYP2C18&19 genes (tg-CYP2C18&19. Methods Hemizygous tg-CYP2C18&19, 11 week old mice were compared with wild-type littermates to obtain information regarding clinical status, clinical pathology and anatomical pathology. After one week of clinical observations, blood samples were collected, organs weighed, and tissues collected for histopathology. Results In males, the tissue weights were lower in tg-CYP2C18&19 than in wild-type mice for brain (p ≤ 0.05, adrenal glands (p ≤ 0.05 and brown fat deposits (p ≤ 0.001 while the heart weight was higher (p ≤ 0.001. In female tg-CYP2C18&19, the tissue weights were lower for brain (p ≤ 0.001 and spleen (p ≤ 0.001 compared to wild-type females. Male tg-CYP2C18&19 had increased blood glucose levels (p ≤ 0.01 while females had decreased blood triglyceride levels (p ≤ 0.01. Conclusion Despite the observed alterations, tg-CYP2C18&19 did not show any macroscopic or microscopic pathology at the examined age. Hence, these hemizygous transgenic mice were considered to be viable and healthy animals.

  12. The 2013 symposium on pathology data integration and clinical decision support and the current state of field

    Directory of Open Access Journals (Sweden)

    Jason M Baron

    2014-01-01

    Full Text Available Background: Pathologists and informaticians are becoming increasingly interested in electronic clinical decision support for pathology, laboratory medicine and clinical diagnosis. Improved decision support may optimize laboratory test selection, improve test result interpretation and permit the extraction of enhanced diagnostic information from existing laboratory data. Nonetheless, the field of pathology decision support is still developing. To facilitate the exchange of ideas and preliminary studies, we convened a symposium entitled: Pathology data integration and clinical decision support. Methods: The symposium was held at the Massachusetts General Hospital, on May 10, 2013. Participants were selected to represent diverse backgrounds and interests and were from nine different institutions in eight different states. Results: The day included 16 plenary talks and three panel discussions, together covering four broad areas. Summaries of each presentation are included in this manuscript. Conclusions: A number of recurrent themes emerged from the symposium. Among the most pervasive was the dichotomy between diagnostic data and diagnostic information, including the opportunities that laboratories may have to use electronic systems and algorithms to convert the data they generate into more useful information. Differences between human talents and computer abilities were described; well-designed symbioses between humans and computers may ultimately optimize diagnosis. Another key theme related to the unique needs and challenges in providing decision support for genomics and other emerging diagnostic modalities. Finally, many talks relayed how the barriers to bringing decision support toward reality are primarily personnel, political, infrastructural and administrative challenges rather than technological limitations.

  13. The prognostic significance of clinical and pathological features in hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Lun-Xiu Qin; Zhao-You Tang

    2002-01-01

    The prognosis of patients with HCC still remains dismal. The life expectancy of HCC patients is hard to predict because of the high possibility of postoperative recurrence. Many factors, such as patient's general conditions, macroscopic tumor morphology, as well as tumor hictopathology features, have been proven of prognostic significance. Female HCC patient often has a better prognosis than male patient, which might be due to the receptor of sex hormones. Younger patients often have tumors with higher invasiveness and metastatic potentials, and their survival and prognosis are worse than the older ones. Co-existing hepatitis status and hepatic functional reserve have been confirmed as risk factors for recurrence. Serum alpha-fetoprotein (AFP) is useful not only for diagnosis, but also as a prognostic indicator for HCC patients. AFP mRNA has been proposed as a predictive marker of HCC cells disseminated into the circulation and for metastatic recurrence. Many pathologic features,such as tumor size, number, capsule state, cell differentiation, venous invasion, intrahepatic spreading, and advanced pTNM stage, are the best-established risk factors for recurrence and important aspects affecting the prognosis of patients with HCC. Marked inflammatory cell infiltration in the tumor could predict a better prognosis. Clinical stage is still the most important factor influencing on the prognosis. Extratumor spreading and lymph nodal metastasis are independent predictors for poor outcome. Soma new predictive systems have recently been proposed. Different strategies of treatment might have significant different effects on the patients'prognosis. To date, surgical resection is still the only potentially curative treatment for HCC,including localized postoperative recurrences.Extent of resection, blood transfusion, occlusion of porta hepatis, and blood loss affect the survival and prognosis of HCC patients. Regional therapies provide alternative ways to improve the prognosis of

  14. Clinical and pathologic factors predictive of biochemical control following post-prostatectomy irradiation

    International Nuclear Information System (INIS)

    Purpose/Objective: Indications for post-prostatectomy radiation therapy are not well defined. We reviewed our experience treating post-prostatectomy patients with external beam irradiation to assess clinical and pathologic factors predictive of biochemical control. Materials and Methods: Between 1/87 and 3/93, 61 patients received post-operative tumor bed irradiation with a median dose of 59.4 Gy (50.4 - 68 Gy). Median follow-up was 4.1 years (7.6 months - 8.3 years) from irradiation. Patients were treated for the following reasons: 1) adjuvantly, within 6 months of surgery for extracapsular extension, seminal vesicle involvement, or positive surgical margins (n=38); 2) persistently elevated PSA post-operatively (n=2); 3) rising PSA >6 months after surgery (n=9); and 4) biopsy proven local recurrence (n=12). No patients had known nodal or metastatic disease. All patients had post-radiation PSA data available. Biochemical control was the endpoint studied using Kaplan-Meier life table analysis. Biochemical control was defined as the ability to maintain an undetectable PSA (4 and ≤1 0, >10 and ≤20, and > 20 ng/ml. The 3 year actuarial rates of biochemical control were 100% for group 1, 66.7% for group 2, 61.5% for group 3, and 28.6% for group 4. Pre-RT PSA values were also evaluated. Univariate Cox models indicated lower presurgical and pre-RT PSA values were predictive of biochemical control (p=0.017, p6 months after surgery (group 3), the 3 year actuarial rate of biochemical control was 55.6%. The 3 year actuarial rate of biochemical control for patients treated for a biopsy proven recurrence (group 4) was 8.3%. By pair-wise log rank test, the rates of biochemical control were significantly different between groups 1 and 3 (p=0.036), groups 1 and 4 (p<0.001), and groups 3 and 4 (p=0.009). Conclusion: Biochemical control was achieved in approximately half of the patients treated with post-operative prostatic fossa irradiation. Elevated presurgical and pre-RT PSA

  15. Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with Pirital virus (Arenaviridae): a rodent model of Lassa fever.

    Science.gov (United States)

    Sbrana, Elena; Mateo, Rosa I; Xiao, Shu-Yuan; Popov, Vsevolod L; Newman, Patrick C; Tesh, Robert B

    2006-06-01

    The clinical laboratory, virologic, and pathologic changes occurring in hamsters after infection with Pirital virus (Arenaviridae) are described. Pirital virus infection in the hamsters was characterized by high titered viremia, leukocytosis, coagulopathy, pulmonary hemorrhage and edema, hepatocellular and splenic necrosis, and marked elevation of serum transaminase levels. All of the animals died within 9 days. The clinical and histopathological findings in the Pirital virus-infected hamsters were very similar to those reported in severe human cases of Lassa fever, suggesting that this new animal model could serve as a low-cost and relatively safe alternative for studying the pathogenesis and therapy of Lassa fever. PMID:16760527

  16. Pathology tickler: an HL7 monitoring system to provide clinical feedback

    Science.gov (United States)

    Mongkolwat, Pattanasak; Davis, Elizabeth; Bhalodia, Pankit; Singh, Harinder; Channin, David S.

    2003-05-01

    The purpose of this project is to develop a software system to provide feedback to radiologists and other clinicians from interventional procedures in which they participate. Using Health Level Seven (HL7) traffic between the anatomy/pathology information system and other major information systems, we were able to develop a semi-automatic 'tickler' system that can notify clinicians of pathology results as well as the absence of pathology results after a specified time interval. By using this system, radiologists can get more rapid feedback concerning their interpretations and thereby learn to distinguish false positive from true positive cases. Potentially, fewer patients would fall through the follow-up cracks when using our system versus a paper-based method. The system demonstrates, among other things, how HL7 information can be a powerful tool at an institution when used for purposes for which it was not intentionally designed.

  17. Relationship between imaging and pathological features and clinical factors in surgical cases of temporal lobe epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Uesugi, Hideji; Matsuda, Hiroshi; Onuma, Teiichi [National Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo (Japan); Shimizu, Hiroyuki; Arai, Nobutaka; Nakayama, Hiroshi; Maehara, Taketoshi; Yanashita, Akira

    1998-03-01

    The relationships between imaging, pathology and presumed causes in surgical cases of temporal lobe epilepsy (TLE) was studied. The subject was 62 patients. MRI, PET and SPECT were performed. Hematoxylin and eosin was used for pathological judgement. On MRI, mesial temporal sclerosis (MTS) was detected in 48 of 52 patients (92%); 32 (62%) had high-signal intensity on T2-weighted images; 31 (60%) had atrophy {l_brace}23 (44%) had high-signal intensity on T2+atrophy{r_brace}; 5 (10%) had calcified lesions; and 2 (4%) had cystic lesions. On PET and SPECT, abnormal cerebral blood flow was noted in 33 of 36 (92%). On pathological findings (61 cases), Ammon`s horn sclerosis (AHS), tumors, gliosis in lateral temporal and meningeal inflammatory finding were detected in 42 (69%), 10 (23%) and 8 (13%) cases, respectively, whereas 2 showed no abnormalities. The 2 patients with normal pathology showed both high-signal intensity and atrophy on MRI. The presumed causes of TLE were encephalitis/meningitis and/or suspected of these diseases in 15 patients (24%), injuries at birth in 5 (8%), and none in 42 (68%). The presumed causes in the 43 patients with AHS were encephalitis/meningitis in 11, injuries at birth in 3, and none in 29. Of the 15 patients in whom encephalitis/meningitis was estimated as the causes of TLE, only 6 (40%) had pathological evidence of meningeal inflammatory finding. Of the 42 patients in whom cause could not be determined, 2 had pathological evidence of meningeal inflammatory finding. (K.H.)

  18. Use of a data warehouse at an academic medical center for clinical pathology quality improvement, education, and research

    Directory of Open Access Journals (Sweden)

    Matthew D Krasowski

    2015-01-01

    Full Text Available Background: Pathology data contained within the electronic health record (EHR, and laboratory information system (LIS of hospitals represents a potentially powerful resource to improve clinical care. However, existing reporting tools within commercial EHR and LIS software may not be able to efficiently and rapidly mine data for quality improvement and research applications. Materials and Methods: We present experience using a data warehouse produced collaboratively between an academic medical center and a private company. The data warehouse contains data from the EHR, LIS, admission/discharge/transfer system, and billing records and can be accessed using a self-service data access tool known as Starmaker. The Starmaker software allows users to use complex Boolean logic, include and exclude rules, unit conversion and reference scaling, and value aggregation using a straightforward visual interface. More complex queries can be achieved by users with experience with Structured Query Language. Queries can use biomedical ontologies such as Logical Observation Identifiers Names and Codes and Systematized Nomenclature of Medicine. Result: We present examples of successful searches using Starmaker, falling mostly in the realm of microbiology and clinical chemistry/toxicology. The searches were ones that were either very difficult or basically infeasible using reporting tools within the EHR and LIS used in the medical center. One of the main strengths of Starmaker searches is rapid results, with typical searches covering 5 years taking only 1-2 min. A "Run Count" feature quickly outputs the number of cases meeting criteria, allowing for refinement of searches before downloading patient-identifiable data. The Starmaker tool is available to pathology residents and fellows, with some using this tool for quality improvement and scholarly projects. Conclusion: A data warehouse has significant potential for improving utilization of clinical pathology testing

  19. Peripheral neuropathy associated with monoclonal IgG of undetermined significance: clinical, electrophysiologic, pathologic and therapeutic study of 14 cases.

    Science.gov (United States)

    Hermosilla, E; Lagueny, A; Vital, C; Vital, A; Ferrer, X; Steck, A; Julien, J

    1996-01-01

    Fourteen patients with peripheral neuropathy and monoclonal IgG of undetermined significance are reported with a retrospective study of the clinical features, electrophysiologic and sural nerve biopsy findings. There were two groups. Five patients had a relapsing chronic sensorimotor polyneuropathy with clinical (5/5), electrophysiologic (4/5) and pathologic (5/5) features compatible with chronic inflammatory demyelinating polyneuropathies (CIDP). The nine others had a slowly progressive sensory (5/9) (SPNP) or sensorimotor (4/9) (SMPNP) axonal polyneuropathy. Four patients of the first group were treated with intravenous human immunoglobulin (400 mg/kg/day for five days) with significant clinical improvement. The motor conduction velocities and distal latencies of two of these patients improved following treatment, thus matching the clinical improvement. Our results on peripheral nerve biopsies confirm the differentiation of patients with CIDP from those with SMPNP and SPNP. There was no specific immunologic serologic reactivity in any of the cases. PMID:10975722

  20. Radiologic-pathologic correlation of the mammographic findings retrospectively detected in inflammatory breast cancer. Usefulness in clinical practice

    International Nuclear Information System (INIS)

    Background. The aim of this study was to describe the clinical, mammographical and pathological characteristics of inflammatory carcinoma. Patients and methods. Clinical, mammographical and histological sections of twenty-two women (age range 28-60 years) were reviewed. The examinations had been performed over a period of four years. Results. The clinical findings were: erythema, edema, thickening of the skin and breast heat in ten patients; palpable mass in nine patients; nipple discharge in one patient; absent in two patients. Pathological findings were: tumor emboli in the dermal lymphatics in eight patients; tumor emboli in the vessels in ten patients; tumor emboli both in the dermal lymphatics and in the vessels in four patients. The radiologic findings were: skin thickening, trabecular thickening and blurring of structure in ten patients (common presentation); mass in nine patients; malignant-type calcifications in two patients (uncommon presentation); absent in one patient. The follow-up examination (eighteen months) detected that only one patient with common presentation of inflammatory carcinoma had no local or systemic recurrence against eight patients with uncommon presentation. Conclusions. The clinical and mammographical aspects, which suggest the presence of an inflammatory carcinoma, occur only in 45.4% of the patients. The radiological aspect seems to correlate with the different prognosis of the tumour, resulting in a better prognosis in those with an uncommon aspect. (author)

  1. Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

    OpenAIRE

    Giovanni Pagano; Annarita Aiello Talamanca; Giuseppe Castello; Mario D Cordero; Marco d’Ischia; Maria Nicola Gadaleta; Federico V Pallardó; Sandra Petrović; Luca Tiano; Adriana Zatterale

    2014-01-01

    Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of...

  2. Clinical and imaging features of male breast disease, with pathological correlation: a pictorial essay

    International Nuclear Information System (INIS)

    The majority of male breast diseases are benign. The most common is gynaecomastia. Although it is rare, the most critical diagnosis is a malignancy. Radiologists are generally less familiar with breast disease in males compared with females. This pictorial review will highlight the ultrasonographic, mammographic and pathological features of a spectrum of benign and malignant male breast diseases. This includes gynaecomastia, fat necrosis, lipoma, epidermoid cyst, subareolar abscess, chronic inflammation, melanoma and ductal carcinoma.

  3. Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

    Directory of Open Access Journals (Sweden)

    Giovanni Pagano

    2014-01-01

    Full Text Available Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver, neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF along with the occurrence of oxidative stress (OS have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involve mitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients.

  4. CREATION OF THE NOMOGRAM THAT PREDICTS PATHOLOGICAL LOCAL EXTENT OF THE BLADDER CANCER BASED ON CLINICAL VARIABLES

    Directory of Open Access Journals (Sweden)

    L. V. Mirylenka

    2012-01-01

    Full Text Available Objective: to develop nomogram based on clinical variables, that predicts pathological local extent of the bladder cancer рТ3-рТ4 (рТ3+.Material and methods: We used data of 511 patients with bladder cancer, that have undergone radical cystectomy between 1999 and 2008 at N.N. Alexandrov National Cancer Centre. For prediction of pT3+ on preoperative data were used mono- and multivariate logistic regression analysis. Coefficients from logistic regression equalization were used to construct nomogram. Nomogram accuracy was evaluated with concordance index (с-index and by building the calibration plot. Internal validation by bootstrap method with 200 variants of dataset was performed.Results: We developed nomogram, that include: clinical stage сТ, tumor grade, tumor macroscopic appearance, presence of upper tract dilatation, prostatic urethra and/or prostatic lobe(s involvement, 3 or more bladder walls involvement, ESR and creatinine level. Bootstrapcorrected prognostic accuracy of nomogram was 81,4%, that 12,6% better than clinical stage accuracy.Conclusion: developed nomogram can significantly improve pathologic tumor stage prediction accuracy that may be used to select patients for neoadjuvant chemotherapy.

  5. Mammographically detected DCIS treated with breast conserving therapy: an analysis of clinical, pathologic, and treatment related factors affecting outcome

    International Nuclear Information System (INIS)

    Purpose: We reviewed our institutions experience treating mammographically detected DCIS with breast conserving therapy (BCT) to determine if any clinical, pathologic, or treatment related factors affected outcome. Methods and Materials: From December of 1980 to November of 1991, 104 breasts in 102 patients were treated with breast conserving therapy at William Beaumont Hospital, Royal Oak, Michigan. All patients underwent at least an excisional biopsy and sixty three patients (61%) had a re-excision. All patients received whole breast irradiation to a median dose of 5040 cGy (range 4314 to 5600 cGy). Ninety seven patients received a supplemental boost to the tumor bed for a median total dose of 6040 cGy (range 4400 to 7183 cGy) using either photons (2 patients), electrons (67 patients), or interstitial implant (28 patients). Results: With a median follow-up of 6.1 years, 5 patients have failed in the treated breast for five and ten year actuarial local control rates of 95.8% and 94% respectively. Thirteen percent of the population have been followed for 10 years or more. Failures developed 27, 29, 36, 38, and 70 months after treatment. Three recurrences were invasive and two were DCIS. All patients were treated with mastectomy. Four patients remain NED a median of 26 months after surgery. One patient failed distantly 36 months after local recurrence for an ultimate cause specific survival of 99%. Potential clinical, pathologic, and treatment related factors affecting outcome are analyzed below. Conclusion: Patients treated with breast conserving therapy for mammographically detected DCIS achieve excellent rates of local control and survival. No clinical, pathologic, or treatment related factor has been associated with outcome. Additional studies are needed to define the subset of patients at risk for local recurrence with BCT

  6. CREATION OF THE NOMOGRAM THAT PREDICTS PATHOLOGICAL LOCAL EXTENT OF THE BLADDER CANCER BASED ON CLINICAL VARIABLES

    OpenAIRE

    L. V. Mirylenka; O. G. Sukonko; A. V. Pravorov; A. I. Rolevich; A. S. Mavrichev

    2014-01-01

    Objective: to develop nomogram based on clinical variables, that predicts pathological local extent of the bladder cancer рТ3-рТ4 (рТ3+).Material and methods: We used data of 511 patients with bladder cancer, that have undergone radical cystectomy between 1999 and 2008 at N.N. Alexandrov National Cancer Centre. For prediction of pT3+ on preoperative data were used mono- and multivariate logistic regression analysis. Coefficients from logistic regression equalization were used to construct nom...

  7. Clinical classification and pathological findings of vestibular schwannoma requiring surgical therapy after stereotactic radiosurgery

    International Nuclear Information System (INIS)

    The present study investigated imaging, intraoperative and pathological findings, and surgical indications and timing in 10 patients [5 men, 5 women; mean age, 52.3 years (range, 17-70 years)] with vestibular schwannoma who underwent surgical therapy due to poor radiotherapy-mediated tumor control; these included Gamma Knife (n=8), X-Knife (n=1) and proton beam (n=1) therapies. The mean period from radiotherapy endpoint until surgery was 63.3 months (range, 30-96 months) and patients were classified according to the time elapsed between radiotherapy and surgical therapy [≥2 to <5 years (n=4); ≥5 to <8 years (n=4); or ≥8 years (n=2)]. Surgical indications were classified into two groups: exacerbated or additional neurological symptoms caused by solid tumor component enlargement (n=2); and exacerbated or additional neurological symptoms with extraparenchymal extension of the tumor cyst (n=8). Imaging findings were classified as large cystic (LC; n=8), multi-micro cystic (MC; n=2), or solid component enlargement (SC; n=0) types. Pathological findings revealed no malignant changes in any patient, and primary pathological conditions comprised radiotherapy-induced exacerbation of vascular occlusion and permeability. MC patients presented marked hemosiderosis and recurrent small hemorrhage was predicted. Intraoperative findings included marked adhesions with peripheral neurons and the cerebellum, as well as arachnoid thickening, rendering complete resection difficult. Decompression surgery was relatively straightforward for LC, which presents little bleeding, but it was challenging for MC due to its hemorrhagic nature. SC cases have been previously reported, but were not found in the present study, which had an inclusion criterion of ≥2 years follow-up after radiotherapy. Other than a single case that became malignant, all of the previously reported cases were within 2 years of radiotherapy and transient swelling may have been present. (author)

  8. Surgical pathology of hypothenar hammer syndrome with new pathogenetic insights: A 25-year institutional experience with clinical and pathologic review of 67 cases.

    Science.gov (United States)

    Larsen, Brandon T; Edwards, William D; Jensen, Mark H; Johnson, Craig H; McBane, Robert D; Harmsen, William S; Maleszewski, Joseph J

    2013-11-01

    Hypothenar hammer syndrome (HHS) is characterized by digital ischemia after repetitive traumatic injury to the ulnar artery. Some hypothesize that susceptible patients have an intrinsic vasculopathy such as fibromuscular dysplasia (FMD). To investigate this hypothesis, we reviewed our institutional experience with this syndrome over 25 years. Clinical records were reviewed from all patients who underwent surgical treatment for HHS (1987 to 2011), and histologic features of excised ulnar arteries were characterized. A total of 67 patients (mean age 45 y; range, 21 to 75 y; 65 men) were treated for unilateral or bilateral disease. Common symptoms included digital pain (96% of cases), cold intolerance (79%), cyanosis (70%), numbness (54%), tingling (51%), and ulceration (40%). Angiography showed ulnar artery occlusion (89%), irregularity (56%), tortuosity (46%), and digital emboli (89%). Common pathologic features (from 75 specimens) included: luminal thrombosis (87%); intimal thickening (60%) and fibrosis (57%); internal elastic membrane disruption (95%); medial fibrosis (96%), hypertrophy (43%), neovascularization (49%), dilatation (29%), and disruption (25%); and adventitial neovascularization (53%). Specific features of dysplasia were present in 10 cases (15%), including smooth muscle disorganization and additional smooth muscle bundles outside the external elastic membrane, but typical FMD was not identified. Histologic features in HHS most often represent secondary changes consistent with repetitive trauma. Dysplastic features can be found in occasional cases, but FMD does not appear to contribute to HHS in most patients. Angiography should be interpreted with caution in superficial locations, as a string-of-beads appearance may simply reflect a posttraumatic corkscrew deformity of the ulnar artery. PMID:23887165

  9. Injuries to the cranial cruciate ligament and associated structures: summary of clinical, radiographic, arthroscopic and pathological findings from 10 horses

    International Nuclear Information System (INIS)

    The clinical, radiographic, arthroscopic and pathological findings of 10 horses with injury to the cranial cruciate ligament are presented. The most consistent clinical signs included moderate to severe distension of the femoropatellar joint and a Grade III to a Grade V out of V lameness. Craniocaudal instability could be elicited in five horses under general anaesthesia and in one conscious horse. Radiographic evaluation of the stifles revealed that avulsion fracture of the medial intercondylar eminence was the most common finding in six out of 10 horses. Arthroscopic examination of the affected femorotibial joints were performed in five horses. This confirmed the presumptive diagnosis of cranial cruciate ligament injury or rupture. Post mortem examinations were performed on two horses which documented partial tears of the cranial cruciate ligament

  10. Clinical pathological and genetic analysis of 2 cases of mitochondrial myopathy presented as acute motor axonal neuropathy

    Directory of Open Access Journals (Sweden)

    Hou-min YIN

    2014-06-01

    Full Text Available Background The main clinical manifestations of mitochondrial myopathy are chronic limb weakness and muscular soreness. Subclinical peripheral nerve injury is also reported, but acute axonal neuropathy.like syndrome concurrent with lactic acidosis is rare. In this paper the clinical features of 2 patients presenting as acute lactic acidosis and sudden muscle weakness were analyzed. Pathological changes and genetic mutations were detected.  Methods Electromyography (EMG and muscle biopsy were performed. Modified Gomori trichrome (MGT and succinodehydrogenase (SDH staining were used to identify pathological changes. Changes of ultra microstructure of muscular tissue were observed under electron microscope. Mitochondrial DNA (mtDNA full length sequencing was performed using 24 pairs of partially overlapping primers.  Results EMG showed a coexistence of neurogenic and myogenic changes. Dramatic decrease of motor nerve amplitude and moderately reduced sensory nerve amplitude were observed but nerve conduction velocity was normal in both patients. Impressive ragged red fibers were seen on MGT staining. Electron microscope showed dramatic mitochondrial abnormalities in Case 1 and paracrystaline inclusions in Case 2. mtDNA sequencing showed 3243A > G mutation in Case 1 and 8344A > G mutation in Case 2. Conclusions Mitochondrial myopathy can present as metabolic crisis like acute lactic acidosis, dyspnea and acute motor axonal neuropathy.like syndrome. It is a life.threatening phenotype that needs more attention. doi: 10.3969/j.issn.1672-6731.2014.06.007

  11. [The pathology of the peritoneo-vaginal process in the young males: clinical and therapeutical aspects in 160 cases].

    Science.gov (United States)

    Fall, P A; Gueye, S M; Ndoye, A; Sylla, C; Abdallahi, M O; Diame, A A; Ba, M; Diagne, B A

    2000-01-01

    The objective of this work was to describe the clinical and therapeutical aspects of pathology of the peritoneo-vaginal process. We have performed a retrospective study including 160 patients operated between January 1990 up to December 1996. Mean age at diagnosis was 8 years, ranged from 1 month to 13 years old. All patients were male. The abnormality was located in the right side in 60% of cases and was bilateral in 6.7% of cases. The main clinical features were scrotal mass (81%) and scrotal pain (13.46%). The diagnosis was made at birth only in 20% of cases. A maldescended testis was associated in 7.5% of cases. A groin incision have been used in 91.25% of patients. The average hospital stay after surgery was 1 day. Thus, the pathology of the peritoneo-vaginal process is common and apparently banal. Need for treatment through a groin incision owing to the possibility of associated maldescended testis. PMID:15779188

  12. Relationship Between Blood Fibrinogen Concentration and Pathological Features of Cancer Patients: A 139-case Clinical Study

    Directory of Open Access Journals (Sweden)

    Da-Yong Lu

    2007-01-01

    Full Text Available Angiogenesis and coagulation are among the most consistent host responses to the presence of a malignant tissue. Pathological angiogenesis and coagulation are often occurred in patients with solid tumors, especially in the occurrence of neoplasm metastasis and as targets for anti-metastatic drugs such as antiangiogenesis agents, coagulation-mediated agents and anticancer drugs. Since fibrinogen (Fib is the most abundant and key haemostatic protein taking part in angiogenesis and coagulation, its biological and pathophysiological roles in cancer patients are intriguing. To continue foundational and translational research on Fib-related cancer pathogenesis, a phase II survey of 139 patients was carried out at the Central Hospital of Jing-An district and Shanghai University, Shanghai, China. The mean BFC of the cancer patients in this survey was overall about 35-50% greater than that in the normal population. This study showed that the mean BFC was higher in patients with long-distance metastases (N1M1 patients than in patients with no sign of long-distance metastases (N0M0 patients. Mean BFCs were 4.42 g/L (n= 21 in patients with lung cancer, 4.36 g/L, and in patients with hepatic cancer (n=5, and 4.63 g/L in patients with stomach cancer (n=8, all higher than the average value of the cancer patients overall (4.16 g/L. However, patients with bowel and colon cancers 3.79 g/L (n=16 showed lower than them. BFC levels increased with increasing cancer duration (latency > 1 year. There was a slight decrease in BFC after one or two treatment cycles, but a more marked decrease after surgery. We propose that the BFC level in cancer patients may be influenced by and related to many aspects of cancer progression such as metastatic conditions, tumor origins, patient’s pathological stage and disease latency. As an important first-hand pathologic-therapeutics relationship study, it provides evidence for the potentiality of a new approach of Fib-targeted as

  13. Pathological, clinical and biochemical investigation of naturally occurring pregnancy toxemia of sheep

    OpenAIRE

    Kabakci N.; Yarim G.; Yarim M.; Duru O.; Yagci B.; Kisa U.

    2003-01-01

    A sick ewe in late pregnancy presented with clinical incoordination lipping, amaurosis, head tilt gait and nervous symptoms such as circling movements. A smell of ketones on the breath was detected. The sick animal died during clinical examination and, together with three more dead animals belonging to the same flock, was submitted to the laboratory for necropsy. The uteri of all pregnant animals contained late-term twin fetuses. The most prominent lesion was extensive fatty infiltration of t...

  14. Digit loss due to Demodex spp. infestation in a dog: clinical and pathological features

    Directory of Open Access Journals (Sweden)

    F. Grandi

    2013-05-01

    Full Text Available Here we describe a rare clinical manifestation of canine pododemodicosis. A dog was presented with pedal erythema, scaling, crusting, severe edema and digit loss. The following diseases were taken into account for the differential diagnosis: pododemodicosis, lethal acrodermatitis, zinc responsive dermatosis and pemphigus foliaceus. Results from skin biopsies revealed the presence of Demodex spp. of mites in the follicular infundibula and a severe inflammatory process (pododemodicosis. Upon the acaricidal treatment, the patient exhibited favorable signs of clinical improvement.

  15. Coxarthrosis and periarticular pathology of the hip: clinical manifestations, diagnosis, approaches to therapy

    Directory of Open Access Journals (Sweden)

    Nadezhda Aleksandrovna Shostak

    2012-03-01

    Full Text Available Osteoarthrosis (OA is the most common joint disease affecting both men and men. There is primary and secondary OA. Up to now, the causes of primary OA remain unclear. Secondary OA is associated with the presence of joint injury in the history, with congenital anomalies of the structure, metabolic diseases, endocrinopathies, etc. It is particularly difficult to interpret coxarthrosis if there are signs offemoroacetabular impingement. Periarticular pathology plays an important role in the origin of the hip pain syndrome that accompanies or mimics the symptoms of coxarthrosis. The main goals of OA therapy are to slow down the progression of cartilage degeneration and to maintain joint function as much as possible. Combination drugs containing chondroitin sulfate and glucosamine hydrochloride are widely used to treat OA today.

  16. Coxarthrosis and periarticular pathology of the hip: clinical manifestations, diagnosis, approaches to therapy

    Directory of Open Access Journals (Sweden)

    Nadezhda Aleksandrovna Shostak

    2012-01-01

    Full Text Available Osteoarthrosis (OA is the most common joint disease affecting both men and men. There is primary and secondary OA. Up to now, the causes of primary OA remain unclear. Secondary OA is associated with the presence of joint injury in the history, with congenital anomalies of the structure, metabolic diseases, endocrinopathies, etc. It is particularly difficult to interpret coxarthrosis if there are signs offemoroacetabular impingement. Periarticular pathology plays an important role in the origin of the hip pain syndrome that accompanies or mimics the symptoms of coxarthrosis. The main goals of OA therapy are to slow down the progression of cartilage degeneration and to maintain joint function as much as possible. Combination drugs containing chondroitin sulfate and glucosamine hydrochloride are widely used to treat OA today.

  17. [An expert system of aiding decision making in breast pathology connected to a clinical data base].

    Science.gov (United States)

    Brunet, M; Durrleman, S; Ferber, J; Ganascia, J G; Hacene, K; Hirt, F; Jouniaux, F; Meeus, L

    1987-01-01

    The René Huguenin Cancer Center holds a medical file for each patient which is intended to store and process medical data. Since 1970, we introduced computerization: a development plan was elaborated and simultaneously a statistical software (Clotilde--GSI/CFRO) was selected. Thus, we now have access to a large database, structured according to medical rationale, and utilizable with methods of artificial intelligence towards three objectives: improved data acquisition, decision making and exploitation. The first application was to breast pathology, which represents one of the Center's primary activities. The structure of the data concerning patients is by all criteria part of the medical knowledge. This information needs to be presented as well as processed with a suitable language. To this end, we chose a language-oriented object, Mering II, usable with Apple and IBM 4 micro-computers. This project has already allowed to work out an operational model. PMID:3620732

  18. Clinical and pathological significance of carotid siphon calcification observed on bone condition of brain CT

    International Nuclear Information System (INIS)

    On plain brain computed tomography (CT), it is difficult to evaluate stenosis of internal carotid artery (ICA) because ICA is surrounded by structures, even though we can observe calcification of carotid siphon in some patients by using bone condition. However the pathologic significance has not been well known. We studied the pathologic significance of carotid siphon calcification observed on bone condition of brain CT. A total of 112 patients who were diagnosed or suspected as cerebrovascular diseases were registered. We classified the calcification into four levels (none, mild, moderate, severe) based on the degree of calcification. Then we compared it with the degree of stenosis of carotid siphon seen on brain magnetic resonance angiography (MRA) and with max intima-medial thickness (IMT) from common carotid artery (CCA) to ICA on carotid ultrasonography. The mean±standard deviation of max IMT to none, mild, moderate and severe in the degree of calcification were 1.03±0.64 (0.4-2.8), 1.65±0.83 (0.5-4.1), 2.03±0.83 (0.8-4.1) and 2.81±1.15 (0.7-6.5) mm, respectively. The calcification on brain CT significantly correlated with the degree of stenosis on brain MRA and with max IMT on carotid ultrasonography. The calcification of carotid siphon on bone condition of brain CT correlated with stenosis of the same portion and atherosclerosis of CCA bifurcation. Recently, on Digital Imaging and Communications in Medicine (DICOM) viewer, clinicians can convert plain condition into bone condition on brain CT due to popularization of picture achieving and communication system (PACS). We should pay attention to calcification of carotid siphon in patients with ischemic cerebrovascular diseases because we can estimate the atherosclerosis of both carotid siphon and CCA bifurcation easily and immediately. (author)

  19. Retroperitoneal cystic masses: CT, clinical, and pathologic findings and literature review.

    Science.gov (United States)

    Yang, Dal Mo; Jung, Dong Hae; Kim, Hana; Kang, Jee Hee; Kim, Sun Ho; Kim, Ji Hye; Hwang, Hee Young

    2004-01-01

    Cystic lesions of the retroperitoneum can be classified as either neoplastic or nonneoplastic. Neoplastic lesions include cystic lymphangioma, mucinous cystadenoma, cystic teratoma, cystic mesothelioma, müllerian cyst, epidermoid cyst, tailgut cyst, bronchogenic cyst, cystic change in solid neoplasms, pseudomyxoma retroperitonei, and perianal mucinous carcinoma. Nonneoplastic lesions include pancreatic pseudocyst, nonpancreatic pseudocyst, lymphocele, urinoma, and hematoma. Because the clinical implications of and therapeutic strategies for retroperitoneal cystic masses vary depending on the cause, the ability to noninvasively differentiate between masses is important. Although there is substantial overlap of computed tomographic (CT) findings in various retroperitoneal cysts, some CT features, along with clinical characteristics, may suggest a specific diagnosis. CT may provide important information regarding lesion location, size, and shape; the presence and thickness of a wall; the presence of septa, calcifications, or fat; and involvement of adjacent structures. The most important clinical parameters include patient gender, age, symptoms, and clinical history. Familiarity with the CT and clinical features of various retroperitoneal cystic masses facilitates accurate diagnosis and treatment. PMID:15371613

  20. Clinical Studies of Postoperative Arterial Infusion Chemotherapy in Patients with Pathologic T3 Esophageal Squamous Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Baodong Liu; Zongjun Dong; Xiuyi Zhi; Qingsheng Xu

    2006-01-01

    OBJECTIVE To evaluate how arterial infusion chemotherapy after radical surgery influences long-term survival of patients with pathologic T3 (pT3) esophageal squamous carcinoma.METHODS We divided 190 patients with pathologic pT3 esophageal squamous carcinoma, confirmed by consecutive radical surgery, into an experimental group (surgery + intra-arterial infusion, 56 T3N0M0 and 52 T3N1M0 cases), and the remaining patients into a control group (surgery alone, 48 T3N0M0 and 34 T3N1M0 cases). The experimental group was sub-grouped into 56 cases (26 T3N0M0 and 30 T3N1M0 cases) receiving 1 or 2 periods of chemotherapy, while 52 cases (30 T3N0M0 and 22 T3N1M0 cases) underwent 3 or more than 3 periods of chemotherapy. We used one to seven courses of selected arterial infusion chemotherapy of cisplatin (80 mg/m2 of body-surface area) and fluorouracil (800 mg/m2) with or without epirubicin at 3~4 weeks post operation. The interval between each period was 3~4 weeks. All cases were followed-up for more than 5 years. Survival rates were calculated by the Kaplan-Meier methods and survival differences between patients with and without selected arterial infusion chemotherapy were compared with the Log-rank test. Prognostic variables were entered into a Cox regression analysis model controlling for age, site, lymph node status, and treatment received.RESULTS The overall survival rates were not significantly different between the experimental group and the control group, but there was better survival for patients who received 3 or more than 3 courses of chemotherapy. Lymph node status (N) was an important factor in the prognosis.CONCLUSION Trans-catheter arterial infusion chemotherapy is a safe and effective method of therapy. Postoperative selective arterial infusion chemotherapy can improve the survival rate in patients with esophageal squamous carcinoma who were previously treated by radical surgery.However, this modality of therapy needs further investigation.

  1. Clinical and liver biopsy pathological features in military patients with liver diseases: An analysis of 231 cases

    Directory of Open Access Journals (Sweden)

    Yan-ling SUN

    2012-06-01

    Full Text Available Objective  To explore epidemiological, serological and histopathological (by liver biopsy features of liver diseases, and clinical manifestations in patients of the Chinese armed forces. Methods  The clinical data of 231 cases of military patients with liver diseases in our hospital were retrospectively analyzed in terms of their age, gender, location of enlistment, services, official rank, clinical manifestation, and laboratory examination, and also pathological characteristics of liver biopsy. Results  Among the 231 hospitalized military patients, 202 were male and 29 were female. The age at onset of the disease ranged from 18 to 73 years (mean age 29.7±9.1. Higher morbidity (48.1% was found in the 18-25 year age bracket, while lower (only about 7.4% in above 55-year-old age bracket. Virus infection accounted for 68.0% and non-virus infection accounted for 32.0%. About 64.9% of the patients suffered from chronic liver disease, while 35.1% from acute liver disease. In addition, the prevalence of liver disease was as high as 47.2% in the soldiers, slightly higher than that in the officers (about 38.1%. Transmission of the disease between comrades in arms accounted approximately for 14.0%. Conclusions  The mean age of onset of liver disease in military personnel is younger, ranging from 18 to 25 years old predominantly, and the incidence is gradually decreased along with the age. The prevalence of liver disease may be higher in soldiers than in officers. There is a higher percentage of virus infection-associated liver ailment and chronic liver ailment. For acute liver ailment, pathological diagnosis by liver biopsy should be made, and timely therapeutic measures should be taken to prevent transformation of acute to chronic stage.

  2. Angiosarcoma of the right atrium. Clinical and pathological study of one case.

    Science.gov (United States)

    Morlino, T; Carbognin, S; Causarano, D; Peranzoni, P F; Vincenzi, M

    1980-01-01

    The case of a patient with angiosarcoma of the right atrium is described with respect to clinical presentation, hemodynamic and angiographic findings and post-mortem examination. The need of a high index of suspicion when dealing with patients who show evidence of systemic venous congestion is stressed. PMID:7189494

  3. Histologically benign but clinically malignant neoplasms in the thorax: CT–pathological overview

    International Nuclear Information System (INIS)

    The purpose of this article is to review the computed tomography (CT) and histopathological features of uncommon primary neoplasms of the thorax that can manifest clinically malignant features (multiplicity of pulmonary nodules, an invasive nature, and metastases or recurrence after surgery) with little evidence of histological malignancy.

  4. Clinical and Pathological Features of Primary Gastrointestinal Non-Hodgkin's Lymphoma

    Institute of Scientific and Technical Information of China (English)

    KangzhiWu; JianminYang; DaliMa; XionminSong; WeipingZhang; XiaopingXu; BiheMin; JianminWang

    2004-01-01

    OBJECTIVE The study was initiated to obtain histologic distribution, clinical features, and treatment results in patients with primary gastrointestinal non-Hodgkin's lymphomas.METHODS Between January 1990 and January 2000, 89 PGI NHL patients were eligible to evaluate clinical features. Histological and immunohistological studies were routinely used and all the specimens were reclassified according to the recently published WHO classification system.RESULTS (1)Clinically, among the 89 patients, there were 24 patients in stage IE,33 in stage IIE,19 in stage IIIE,and 13 in stage IVE. (2)Immunohistological studies revealed 72 patients were with B-cell type and only 17 with T-cell type. (3)Altogether, 15 MALT lymphoma were diagnosed among 89 PGI NHL patients, and 14/15 were found primary in the stomach.(4)The 3-year and 5-year overall survival were 77.0% (57/74) and 53.6% (30/56)for the total group.CONCLUSION No clinical symptoms and signs were found to be specific for the diagnosis of PGI NHL. Most patients were in stage IE and liE when diagnosed and the intermediate grade and B-cell type were more common than the others. Surgical resection of the tumor and standard combined chemotherapy post surgery were suggested to be the most effective measures for the long term survival of the PGI NHL patients.

  5. MULTIPLANAR MRI AND CT IMAGING OF SELLAR AND PARASELLAR TUMOURS WITH CLINICAL AND PATHOLOGICAL CORRELATION

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    Aswini Jyothi

    2016-03-01

    Full Text Available AIMS AND OBJECTIVES  To review the anatomy of sellar and parasellar regions.  To review a systematic anatomic approach to differential diagnosis of a sellar or parasellar tumors.  To correlate the diagnosis on magnetic resonance imaging with pathological DIAGNOSIS. MATERIALS AND METHODS A Prospective study of a total of 40 consecutive patients who were referred to the department of Radiodiagnosis, Osmania General Hospital from December 2010 and September 2012 were included in the study after informed consent. RESULTS Majority of patients were between 20 to 40 years. Male preponderance was seen (Males 26, females 14. Commonest tumor encountered in our study was pituitary adenoma (65% among which macro adenomas constituted about 50% of the cases and 15% of cases were micro adenomas. Most of the functioning adenomas were seen in females - of which prolactinoma was the commonest. CONCLUSION MR imaging is preferred over CT for the diagnosis of pituitary adenomas because it provides multiplanar high contrast images, higher definition of small sellar lesions (Microadenomas of the pituitary and further it improves anatomical definition of the pituitary, optic chiasma compression, cavernous sinus invasion before surgery. It is also preferred for postsurgical surveillance. CT has a complementary role in delineating bony destruction and the visualization of calcification and preoperative planning. Coronal images are the best for anatomical details of this region.

  6. Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context

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    Paulette Bioulac-Sage

    2013-01-01

    Full Text Available In Europe and North America, hepatocellular adenomas (HCA occur, classically, in middle-aged woman taking oral contraceptives. Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65 years. HCA have been observed in many pathological conditions such as glycogenosis, familial adenomatous polyposis, MODY3, after male hormone administration, and in vascular diseases. Obesity is frequent particularly in inflammatory HCA. The background liver is often normal, but steatosis is a frequent finding particularly in inflammatory HCA. The diagnosis of HCA is more difficult when the background liver is fibrotic, notably in vascular diseases. HCA can be solitary, or multiple or in great number (adenomatosis. When nodules are multiple, they are usually of the same subtype. HNF1α-inactivated HCA occur almost exclusively in woman. The most important point of the classification is the identification of β-catenin mutated HCA, a strong argument to identify patients at risk of malignant transformation. Some HCA already present criteria indicating malignant transformation. When the whole nodule is a hepatocellular carcinoma, it is extremely difficult to prove that it is the consequence of a former HCA. It is occasionally difficult to identify HCA remodeled by necrosis or hemorrhage.

  7. Early and late-onset acute GvHD following hematopoietic cell transplantation: CT features of gastrointestinal involvement with clinical and pathological correlation

    International Nuclear Information System (INIS)

    Objective: With the introduction of non-myeloablative hematopoietic cell transplantation, acute graft-versus-host-disease (GvHD) is frequently observed beyond the traditional 100 days cut-off. The aim of this study was to describe and compare CT features of gastrointestinal early and late-onset GvHD and to correlate findings with clinical and pathology grading. Subjects and methods: Abdominal CT scans were obtained in 20 patients with early and 15 with late-onset GvHD. Examinations were assessed for intestinal and extraintestinal abnormalities and findings compared between the two subgroups of GvHD. Distinct CT abnormalities as well as a CT-score integrating multiple pathologies were correlated with gut, clinical or pathology grading. Results: Frequent intestinal abnormalities included wall thickening, abnormal enhancement, and excessive fluid-filling (94%, 89%, and 94%). 86% of patients showed concomitant small and large bowel involvement. A discontinuous distribution was observed in 54%. Bile tract abnormality was the most common extra-intestinal finding (74%). The distribution of pathologies was equal between subgroups of early or late-onset disease. Wall thickening and mucosal attenuation in non-enhanced scans were significantly related to clinical and pathology scores (P ≤ 0.018). Number of abnormal segments, small bowel dilatation, engorgement of the vasa recta, mesenteric fat stranding and ascites were linked to clinical grading (P ≤ 0.019). A CT-score integrating multiple abnormalities was correlated to gut, overall clinical and pathology grading (r = 0.64, 0.57, 0.50). Conclusion: CT morphology of acute GvHD is independent of its time of onset and, thus, facilitates differential diagnosis of late-onset acute GvHD. Correlation of CT morphology with clinical and pathological grading is important in terms of prognosis and may help guiding the therapeutic approach.

  8. CLINICAL AND PATHOLOGICAL FINDINGS OF OVARIAN CYSTS, TORSION OVER THE PERIOD OF TEN YEARS (2001-2011

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    Najafiyan Mahin

    2012-12-01

    Full Text Available Ovarian tumors and cysts are major problem in women. Rupture and torsion are major damages which may lead to abdominal pain and acute abdomen. Cysts are the most prevalent pelvic mass in pregnancy and often associated with function disorders of menstruation which are mostly improved spontaneously. In some cases which are the result of cyst rupture, torsion or bleeding in to the cyst, laparotomy may be needed. This was a prospective-descriptive study that has been performed during 10 years, 155 cases with adnexal torsion were studied from the pathological and clinical point of view. Data was analysed using SPSS, version 16. The most prevalent age was 20-30 years, and almost all the cases had abdominal pain. The right ovarian was engaged in 78% of cases, and 1% were bilateral. From pathological point of view, the most prevalent type of functional mass was follicular and luteal, which luteal was more prevalent followed by dermoid cyst. In 19% of cases, adnexal torsion occurred in pregnant women. One of the important causes for abdominal pain is adnexal torsion, especially during pregnancy and delayed in diagnosis, may lead to peritonitis necrosis, it should be considered always as an emergency case. Early diagnosis is necessary to preserve adnex. In this study, the most prevalent parts are right adnex, functional mass type and finally dermoid cyst.

  9. Clinical, functional and pathological correspondence in early stage idiopathic pulmonary fibrosis: evidence for small airway obstruction 1-2.

    Science.gov (United States)

    Myre, M; Allard, S; Bernard, C; Martin, R R

    1988-01-01

    We describe the clinical, physiological and pathological features of 23 subjects with early stage idiopathic pulmonary fibrosis. Thirteen subjects who had no symptoms had been fortuitously recruited by a routine chest radiograph, whereas the 10 other subjects complained of dyspnea. Twenty-one subjects showed only light to moderate extent of abnormalities on the chest radiograph. Fourteen subjects had a reduced vital capacity whereas 16 and 17 showed a reduced pulmonary compliance and an increase in lung elastic recoil, respectively. Transfer factor was significantly reduced in 18 subjects. Evidence for significant airway obstruction, mainly located at the peripheral level, was demonstrated by a reduced specific lung conductance and upstream conductance in 13 subjects. Airway obstruction was not associated with smoking habits. Bronchial hyperresponsiveness was noted in 50% of the 18 subjects studied. Although fibrosis was mild to moderate in 15 instances, it was only focal, i.e. at least one zone of normal parenchyma in the lung specimen in 17 subjects. Peribronchial fibrosis was established in 8/11 satisfactory biopsy specimens. Significant correlations were observed between rales, the radiological score, some functional indices and the characteristics of fibrosis. We conclude that small airway obstruction documented by physiological and pathological means is frequent in early stage idiopathic pulmonary fibrosis. PMID:3420306

  10. Clinical and Pathologic Evaluation of Chronic Bartonella henselae or Bartonella clarridgeiae Infection in Cats

    OpenAIRE

    Kordick, Dorsey L.; Brown, Talmage T.; Shin, KwangOk; Edward B Breitschwerdt

    1999-01-01

    Human Bartonella infections result in diverse medical presentations, whereas many cats appear to tolerate chronic bacteremia without obvious clinical abnormalities. Eighteen specific-pathogen-free cats were inoculated with Bartonella henselae- and/or Bartonella clarridgeiae-infected cat blood and monitored for 454 days. Relapsing bacteremia did not correlate with changes in protein profiles or differences in antigenic protein recognition. Intradermal skin testing did not induce a delayed type...

  11. Metataxonomic and Metagenomic Approaches vs. Culture-Based Techniques for Clinical Pathology

    OpenAIRE

    Hilton, Sarah K.; Castro-Nallar, Eduardo; Pérez-Losada, Marcos; Toma, Ian; McCaffrey, Timothy A.; Hoffman, Eric P; Siegel, Marc O.; Simon, Gary L.; Johnson, W. Evan; Crandall, Keith A.

    2016-01-01

    Diagnoses that are both timely and accurate are critically important for patients with life-threatening or drug resistant infections. Technological improvements in High-Throughput Sequencing (HTS) have led to its use in pathogen detection and its application in clinical diagnoses of infectious diseases. The present study compares two HTS methods, 16S rRNA marker gene sequencing (metataxonomics) and whole metagenomic shotgun sequencing (metagenomics), in their respective abilities to match the...

  12. Clinical and surgical-pathological staging in early non-small cell lung cancer

    OpenAIRE

    Ioannis Koukis; Ioannis Gkiozos; Ioannis Ntanos; Elias Kainis; Konstantinos N. Syrigos

    2013-01-01

    Staging is of the utmost importance in the evaluation of a patient with non-small cell lung cancer (NSCLC) because it defines the actual extent of the disease. Accurate staging allows multidisciplinary oncology teams to plan the best surgical or medical treatment and to predict patient prognosis. Based on the recommendation of the International Association for the Study of Lung Cancer (IASLC), a tumor, node, and metastases (TNM) staging system is currently used for NSCLC. Clinical staging (c-...

  13. Clinical, microbiological and pathological findings of Mycobacterium ulcerans infection in three Australian Possum species.

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    Carolyn R O'Brien

    Full Text Available BACKGROUND: Buruli ulcer (BU is a skin disease caused by Mycobacterium ulcerans, with endemicity predominantly in sub-Saharan Africa and south-eastern Australia. The mode of transmission and the environmental reservoir(s of the bacterium and remain elusive. Real-time PCR investigations have detected M. ulcerans DNA in a variety of Australian environmental samples, including the faeces of native possums with and without clinical evidence of infection. This report seeks to expand on previously published findings by the authors' investigative group with regards to clinical and subclinical disease in selected wild possum species in BU-endemic areas of Victoria, Australia. METHODOLOGY/PRINCIPAL FINDINGS: Twenty-seven clinical cases of M. ulcerans infection in free-ranging possums from southeastern Australia were identified retrospectively and prospectively between 1998-2011. Common ringtail possums (Pseudocheirus peregrinus, a common brushtail possum (Trichosurus vulpecula and a mountain brushtail possum (Trichosurus cunninghami were included in the clinically affected cohort. Most clinically apparent cases were adults with solitary or multiple ulcerative cutaneous lesions, generally confined to the face, limbs and/or tail. The disease was minor and self-limiting in the case of both Trichosurus spp. possums. In contrast, many of the common ringtail possums had cutaneous disease involving disparate anatomical sites, and in four cases there was evidence of systemic disease at post mortem examination. Where tested using real-time PCR targeted at IS2404, animals typically had significant levels of M. ulcerans DNA throughout the gut and/or faeces. A further 12 possums without cutaneous lesions were found to have PCR-positive gut contents and/or faeces (subclinical cases, and in one of these the organism was cultured from liver tissue. Comparisons were made between clinically and subclinically affected possums, and 61 PCR-negative, non-affected individuals

  14. Postsurgical pathologies associated with intradural electrical stimulation in the central nervous system: design implications for a new clinical device.

    Science.gov (United States)

    Gibson-Corley, Katherine N; Flouty, Oliver; Oya, Hiroyuki; Gillies, George T; Howard, Matthew A

    2014-01-01

    Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk of certain postsurgical complications, it became exclusively epidural eventually. Here we review the relevant clinical and experimental pathologic findings, including spinal cord compression, infection, hematoma formation, cerebrospinal fluid leakage, chronic fibrosis, and stimulation-induced neurotoxicity, associated with the early approaches to subdural electrical stimulation of the central nervous system, and the spinal cord in particular. These findings may help optimize the safety and efficacy of a new approach to subdural spinal cord stimulation now under development. PMID:24800260

  15. Effects of radiation therapy for Hodgkin's disease in a child with ataxia telangiectasia: a clinical, biological and pathologic study

    International Nuclear Information System (INIS)

    Stage I lymphocyte-predominant Hodgkin's disease was diagnosed in a 44-month-old girl. Although immune deficiency was suspected and IgA deficiency demonstrated, the diagnosis of an ataxia-telangiectasia (AT)-like syndrome was not confirmed until eight weeks later when results of studies on the radiosensitivity of cultured skin fibroblasts were available. The child had none of the usual physical stigmata of AT. Severe acute radiation damage followed the treatment of this child with standard doses of radiation therapy. Clinical, pathologic, and radiobiologic correlations are drawn. The diagnosis of a malignant lymphoma disorder in children under the age of five should alert clinicians to the possibility of immune deficiency and, even in the absence of classical physical signs, to AT in particular. Suggestions for the management of future similar cases are put forward

  16. Clinical and pathological correlations of C4d immunostaining and its infl uence on the outcome of kidney transplant recipients

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    Virna Nowotny Carpio

    2011-09-01

    Full Text Available INTRODUCTION: C4d is a marker of antibody-mediated rejection (ABMR in kidney allografts, although cellular rejection also have C4d deposits. OBJECTIVE: To correlate C4d expression with clinico-pathological parameters and graft outcomes at three years. METHODS: One hundred forty six renal transplantation recipients with graft biopsies by indication were included. C4d staining was performed by paraffin-immunohistochemistry. Graft function and survival were measured, and predictive variables of the outcome were determined by multivariate Cox regression. RESULTS: C4d staining was detected in 48 (31% biopsies, of which 23 (14.7% had diffuse and 25 (16% focal distribution. Pre-transplantation panel reactive antibodies (%PRA class I and II were significantly higher in C4d positive patients as compared to those C4d negative. Both glomerulitis and pericapillaritis were associated to C4d (p = 0.002 and p < 0.001, respectively. The presence of C4d in biopsies diagnosed as no rejection (NR, acute cellular rejection (ACR or interstitial fibrosis/ tubular atrophy (IF/TA did not impact graft function or survival. Compared to NR, ACR and IF/TA C4d-, patients with ABMR C4d+ had the worst graft survival over 3 years (p = 0.034, but there was no difference between ABMR versus NR, ACR and IF/TA that were C4d positive (p = 0.10. In Cox regression, graft function at biopsy and high %PRA levels were predictors of graft loss. CONCLUSIONS: This study confirmed that C4d staining in kidney graft biopsies is a clinically useful marker of ABMR, with well defined clinical and pathological correlations. The impact of C4d deposition in other histologic diagnoses deserves further investigation.

  17. Correlation Between Clinical-Pathologic Factors and Long-Term Follow-Up in Young Breast Cancer Patients

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    Yue Zhao

    2015-08-01

    Full Text Available OBJECTIVE: Diagnosis of breast cancer in young patients (≤35 correlates with a worse prognosis compared to their older counterparts (>35. The aim of this study is to evaluate the relevance of clinical-pathologic factors and prognosis in young (≤35 breast cancer patients. METHODS: One hundred thirty-two patients of operable breast cancer who were younger than 35 are analyzed in this study. They were treated in our hospital between January 2006 and December 2012. Patients are classified into four molecular subtypes based on the immunohistochemical profiles of estrogen receptor (ER, progesterone receptor (PR, human epidermal growth factor receptor 2 (HER2, and Ki-67. Clinical and pathologic factors have been combined to define a specific classification of three risk levels to evaluate the prognosis of these young women. RESULTS: Patients whose ages are less than 30 have poorer prognosis than patients whose ages are between 31 and 35. The status of lymph nodes post-surgery seems to be the only factor related to patient age in young patients. The patients in level of ER+ or PR+ and HER2−/+ status have the worst prognosis in hormone receptor–positive breast cancer. Group 3 in risk factor grouping has the poorer prognosis than the other two groups. CONCLUSIONS: Patient age and axillary lymph nodes post-surgery are the independent and significant predictors of distant disease-free survival, local recurrence-free survival, and overall survival. The absence of PR relates to poor prognosis. The risk factor grouping provides a useful index to evaluate the risk of young breast cancer to identify subgroups of patients with a better prognosis.

  18. Next generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics

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    Rama R Gullapalli

    2012-01-01

    Full Text Available The Human Genome Project (HGP provided the initial draft of mankind′s DNA sequence in 2001. The HGP was produced by 23 collaborating laboratories using Sanger sequencing of mapped regions as well as shotgun sequencing techniques in a process that occupied 13 years at a cost of ~$3 billion. Today, Next Generation Sequencing (NGS techniques represent the next phase in the evolution of DNA sequencing technology at dramatically reduced cost compared to traditional Sanger sequencing. A single laboratory today can sequence the entire human genome in a few days for a few thousand dollars in reagents and staff time. Routine whole exome or even whole genome sequencing of clinical patients is well within the realm of affordability for many academic institutions across the country. This paper reviews current sequencing technology methods and upcoming advancements in sequencing technology as well as challenges associated with data generation, data manipulation and data storage. Implementation of routine NGS data in cancer genomics is discussed along with potential pitfalls in the interpretation of the NGS data. The overarching importance of bioinformatics in the clinical implementation of NGS is emphasized. [7] We also review the issue of physician education which also is an important consideration for the successful implementation of NGS in the clinical workplace. NGS technologies represent a golden opportunity for the next generation of pathologists to be at the leading edge of the personalized medicine approaches coming our way. Often under-emphasized issues of data access and control as well as potential ethical implications of whole genome NGS sequencing are also discussed. Despite some challenges, it′s hard not to be optimistic about the future of personalized genome sequencing and its potential impact on patient care and the advancement of knowledge of human biology and disease in the near future.

  19. Pathological, clinical and biochemical investigation of naturally occurring pregnancy toxemia of sheep

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    Kabakci N.

    2003-01-01

    Full Text Available A sick ewe in late pregnancy presented with clinical incoordination lipping, amaurosis, head tilt gait and nervous symptoms such as circling movements. A smell of ketones on the breath was detected. The sick animal died during clinical examination and, together with three more dead animals belonging to the same flock, was submitted to the laboratory for necropsy. The uteri of all pregnant animals contained late-term twin fetuses. The most prominent lesion was extensive fatty infiltration of the liver. Massive lipidosis and lipid vacuoles were seen in sections of the livers. In three brains, there was prominent vacuolation in the white matter. Urine analysis revealed ketonuria in most of the suspected sheep from the same flock. Serum glucose, cholesterol, high density lipoprotein cholesterol, and blood urea nitrogen concentrations were lower (p£0.05 and serum triglycerides aspartate aminotransferase and alanine aminotransferase activities were higher (p£0.05 in these sheep than in the controls. After a change of diet and treatment, with glucose and dexamethasone serum glucose levels significantly increased (p£0.001 and urine ketone bodies decreased but the other biocemical differences remained.

  20. THE STUDY OF COLORECTAL CARCINOMA ASSOCIATED ANTIGEN LEA IN CLINICAL PATHOLOGICAL DIAGNOSIS

    Institute of Scientific and Technical Information of China (English)

    冯慧; 宋今丹

    2002-01-01

    Objective: To study the expression and the clinical significance of LEA in colorectal carcinoma. Methods: Immunohistochemistry S-P method to detect the expression of LEA and CEA in 140 colorectal cancer specimens and 100 non-cancerous colorectal specimens. Results: The expression of LEA is relative to tumor differentiation degree and exhibits higher selectivity in well-differentiated adeno-carcinoma (P0.05). Compared with CEA, the expression of LEA has lower positive rate in non-cancerous tissue (P<0.05). The positive rate of LEA in adenoma is much higher than surrounding non-cancerous mucosa and normal mucosa. In normal mucosa the positive rate of LEA is obviously lower than that of CEA (P<0.05). The expression of LEA and CEA has similar rule except in normal mucosa. In histological diagnosis of colorectal cancer the sensitivity of LEA is 82.9% and the specificity is 48%, while the sensitivity of CEA is 88.6% and the specificity is 35%. Conclusion: The expression of LEA is related to the differentiation degree of colorectal cancer tissue. LEA can be used as an auxiliary index for early diagnosis and a reference for the judgment of the malignancy degree of colorectal carcinoma, thus may be a new tumor marker with applicable clinic value.

  1. Clinical and pathological aspects of chronic Senecio spp. poisoning in sheep

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    Paula R. Giaretta

    2014-10-01

    Full Text Available This paper describes an outbreak of chronic Senecio spp. poisoning in grazing sheep in Rio Grande do Sul, Brazil, causing the death of 10 out of 860 adult sheep. Eight sick ewes were euthanized and necropsied. Cattle from this farm were also affected. Clinical signs included progressive weight loss, apathy and photosensitization. Four out of seven tested sheep had increased gamma-glutamyl transferase serum activity and two of them presented serum elevation of alkaline phosphatase. At necropsy, three out of eight ewes presented slightly irregular toughened livers with multifocal nodules, two out of eight ewes had a whitish liver with thickened fibrotic Glisson's capsule partially adhered to the diaphragm, and three out of eight ewes had smooth and grossly normal livers. Necropsy findings attributed to liver failure included hydropericardium (7/8, ascites (5/8, icterus (2/8, hydrothorax (1/8, and edema of mesentery (1/8. The main hepatic histological findings that allowed the establishment of the diagnosis were megalocytosis, proliferation of bile ducts and fibrosis. Spongy degeneration was observed in the brains of all eight necropsied sheep and was more severe at the cerebellar peduncles, mesencephalon, thalamus, and pons. These are suggested as the portions of election to investigate microscopic lesions of hepatic encephalopathy in sheep with chronic seneciosis. The diagnosis of Senecio spp. poisoning was based on epidemiology, clinical signs, laboratory data, necropsy and histological findings.

  2. Pulmonary alveolar microlithiasis: an overview of clinical and pathological features together with possible therapies.

    Science.gov (United States)

    Lauta, Vito Michele

    2003-10-01

    Pulmonary alveolar microlithiasis is characterized by the presence in pulmonary alveolus of round shaped little bodies containing concentric calcareous lamellas. The incidence is similar in all continents, in both sexes and it is higher in age brackets between 20 and 50 years. The disease is prevalent among family units. Clinical reports may suggest the hypothesis that the disease may be hereditary. Pathogenetic hypotheses may indicate that a reduced lung mucociliary function leading to an excess of alveolar mucus may induce the formation of alveolar microliths by mucus condensation. Microliths may appear either confined in particular areas of the lung or widespread. Chemically, microliths consist of large amounts of calcium and phosphorus and, in reference to histology, they consist of calcareous concentric lamellas which are placed around an amorphous or granular central nucleus. The dissociation between definite X-ray pattern of lungs and relative poor clinical symptoms is the most common characteristics of the disease. However, a certain degree of dyspnea with a productive cough may occur together with a sporadic hemoptysis and thoracic pains. X-ray pattern of the lung reveals dissemination of radio-opaque nodules which may make lungs appear to be sprinkled with sand. The evolutive course of the disease leads to pulmonary insufficiency which is related to the increase of number of microliths in several areas of lungs. The inability to identify clear etiological and pathogenetic elements makes difficult therapeutic approach which is palliative such as the use of diphosphonate, steroids and therapeutic BAL. PMID:14561014

  3. Clinical and pathologic factors associated with survival in young adult patients with fibrolamellar hepatocarcinoma

    International Nuclear Information System (INIS)

    Fibrolamellar Carcinoma (FLC), a subtype of hepatocellular carcinoma (HCC), is a rare primary hepatic malignancy. Several aspects of the clinic features and epidemiology of FLC remain unclear because most of the literature on FLC consists of case reports and small cases series with limited information on factors that affect survival. We did a retrospective analysis of the clinical and histological characteristics of FLC. We also determined the rate of cellular proliferation in biopsies of these tumors. We assessed whether these variables were associated with survival. We found 15 patients with FLC out of 174 patients with HCC (8.6%). Between patients with these neoplasms, we found statistically significant survival, age at onset, level of alpha fetoprotein, and an earlier stage of the disease. The 1, 3 and 5 year survival in patients with FLC was of 66, 40 and 26% respectively. The factors associated with a higher survival in patients with FLC were age more than 23 years, feasibility of surgical resection, free surgical borders, absence of thrombosis or invasion to hepatic vessels and the absence of alterations in liver enzymes. The size of the tumor, gender, cellular proliferation and atypia did not affect the prognosis. We concluded that FLC patients diagnosed before 23 years of age have worse prognosis than those diagnosed after age 23. Other factors associated with worse prognosis in this study are: lack of surgical treatment, presence of positive surgical margins, vascular invasion, and altered hepatic enzymes

  4. Metataxonomic and Metagenomic Approaches vs. Culture-Based Techniques for Clinical Pathology

    Science.gov (United States)

    Hilton, Sarah K.; Castro-Nallar, Eduardo; Pérez-Losada, Marcos; Toma, Ian; McCaffrey, Timothy A.; Hoffman, Eric P.; Siegel, Marc O.; Simon, Gary L.; Johnson, W. Evan; Crandall, Keith A.

    2016-01-01

    Diagnoses that are both timely and accurate are critically important for patients with life-threatening or drug resistant infections. Technological improvements in High-Throughput Sequencing (HTS) have led to its use in pathogen detection and its application in clinical diagnoses of infectious diseases. The present study compares two HTS methods, 16S rRNA marker gene sequencing (metataxonomics) and whole metagenomic shotgun sequencing (metagenomics), in their respective abilities to match the same diagnosis as traditional culture methods (culture inference) for patients with ventilator associated pneumonia (VAP). The metagenomic analysis was able to produce the same diagnosis as culture methods at the species-level for five of the six samples, while the metataxonomic analysis was only able to produce results with the same species-level identification as culture for two of the six samples. These results indicate that metagenomic analyses have the accuracy needed for a clinical diagnostic tool, but full integration in diagnostic protocols is contingent on technological improvements to decrease turnaround time and lower costs. PMID:27092134

  5. Toxoplasma encephalitis in Haitian adults with acquired immunodeficiency syndrome: a clinical-pathologic-CT correlation

    International Nuclear Information System (INIS)

    The clinical data, histologic findings, and computed tomographic (CT) abnormalities in eight adult Haitians with toxoplasma encephalitis were analyzed retrospectively. Diagnosis was established by identification of Toxoplasma gondii on autopsy in five and brain biopsy in three specimens and subsequently confirmed by the immunoperoxidase method. All these patiens, six of whom had been in the United States for 24 months or less, had severe idiopathic immunodeficiency syndrome. All were lymphopenic and six were on treatment for tuberculosis when the toxoplasma encephalitis developed. All patients were studied with CT when they developed an altered mental status and fever associated with seizures and/or focal neurologic deficits. Scans before treatment showed multiple intraparenchymal lesions in seven and a single lesion in the thalamus in one. Ring and/or nodular enhancement of the lesions was found in six and hypodense areas in two. Progressions of abnormalities occurred on serial studies. These CT findings that were best shown on axial and coronal thin-section double-dose contrast studies were useful but not diagnostically pathognomonic. In patients with similar clinical presentation CT is recommended to identify focal areas of involvement and to guide brain biopsy or excision so that prompt medical thereapy of this often lethal infection can be instituted

  6. Clinical and pathological studies on intoxication in horses from freshly cut Jimson weed (Datura stramonium-contaminated maize intended for ensiling : clinical communication

    Directory of Open Access Journals (Sweden)

    R. Binev

    2006-06-01

    Full Text Available Spontaneous intoxication in 34 horses after ingesting freshly harvested maize that was to be used for ensiling and heavily contaminated with young Datura stramonium plants, is described. The clinical status of all horses was monitored for 7 days, and included body (rectal temperature, respiratory and heart rates, colour and moistness of visible mucosae, changes in pupil size, appetite, thirst, general behaviour, locomotion, sensory perceptions, urination and defaecation. The intoxication was accompanied by altered clinical status, namely mild hyperthermia, tachycardia, polypnoea, dyspnoea and shallow breathing, mydriasis, dry oral, rectal, vaginal and nasal mucosae, acute gastric dilatation and severe intestinal gas accumulation, anorexia to complete refusal of feed, decreased or absent thirst, absence of defaecation and urination. As a result of the treatment, the clinical parameters normalised between days 2 and 5. Necropsies and pathological studies were performed on two horses that died, revealing toxic liver dystrophy, cardiac lesions and substantial dystrophic and necrotic processes in the kidneys. The observed clinical signs, the pathomorphological changes and the applied therapy could be used in the diagnosis, differential diagnosis, prognosis and treatment of Jimson weed intoxication.

  7. New way in pathologic diagnosis of biliary obstructive jaundice: a clinical study in percutaneous transhepatic cholangiobiopsy

    International Nuclear Information System (INIS)

    Objective: To explore the technical feasibility and sensitivity of percutaneous transhepatic cholangiobiopsy in malignant obstructive jaundice, together with the guidance for clinical managements. Methods: 31 patients with obstructive jaundice after percutaneous transhepatic cholangiography and drainage were undergone percutaneous transhepatic cholangiobiopsy. The technique was performed through an preexisted percutaneous transhepatic tract with a 8-Frerch sheath, multiple specimens were obtained after passing the forceps for the biopsy. The specimens were fixed with formalin, and then taken for histopathologic diagnosis. Results: The histopathologic diagnosis was acquired in 30 of 31 patients (sensitivity, 96.8%). Conclusions: Percutaneous transhepatic cholangiobiopsy is an accurate, safety and reliable way, easy to perform with a histopathologic diagnosis sensitivity rate of 96.8%

  8. Liver disease in brucellosis. A clinical and pathological study of 40 cases

    Science.gov (United States)

    Cervantes, F.; Carbonell, J.; Bruguera, M.; Force, L.; Webb, S.

    1982-01-01

    Among 82 patients with brucellosis, physical and/or biochemical abnormalities suggesting liver disease were found in 40 cases. A soft and tender liver enlargement was present in 65% of them, and the spleen was palpable in 52%. The most frequent biochemical abnormalities were a slight increase of serum transaminases and alkaline phosphatase. Liver biopsy showed a non-specific reactive hepatitis in 90% of patients, and minimal changes in the remaining 10%. Non-caseating granulomas were present in 28 patients, always associated with reactive hepatitis. No differences were found when comparing clinical and biochemical features in patients with and without granulomas. However, statistically significant differences were obtained when the duration of the process was related to the type of alteration found in the liver biopsy; the finding of granulomas was practically constant when the duration of the disease before liver biopsy was under 100 days, but was infrequent after this time. ImagesFig. 1Fig. 2Fig. 3 PMID:7122367

  9. Target volume definition for external beam partial breast radiotherapy: Clinical, pathological and technical studies informing current approaches

    International Nuclear Information System (INIS)

    Partial breast irradiation (PBI) is currently under investigation in several phase III trials and, following a recent consensus statement, its use off-study may increase despite ongoing uncertainty regarding optimal target volume definition. We review the clinical, pathological and technical evidence for target volume definition in external beam partial breast irradiation (EB-PBI). The optimal method of tumour bed (TB) delineation requires X-ray CT imaging of implanted excision cavity wall markers. The definition of clinical target volume (CTV) as TB plus concentric 15 mm margins is based on the anatomical distribution of multifocal and multicentric disease around the primary tumour in mastectomy specimens, and the clinical locations of local tumour relapse (LR) after breast conservation surgery. If the majority of LR originate from foci of residual invasive and/or intraduct disease in the vicinity of the TB after complete microscopic resection, CTV margin logically takes account of the position of primary tumour within the surgical resection specimen. The uncertain significance of independent primary tumours as sources of preventable LR, and of wound healing responses in stimulating LR, increases the difficulties in defining optimal CTV. These uncertainties may resolve after long-term follow-up of current PBI trials. By contrast, a commonly used 10 mm clinical to planning target volume (PTV) margin has a stronger evidence base, although departmental set-up errors need to be confirmed locally. A CTV-PTV margin >10 mm may be required in women with larger breasts and/or large seromas, whilst the role of image-guided radiotherapy with or without TB markers in reducing CTV-PTV margins needs to be explored.

  10. Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer

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    Maria Salete Costa Gurgel

    2011-12-01

    Full Text Available There is a lack of consensus about the influence of GST M1/T1 gene deletions (DEL on sporadic breast cancer (SBC. To evaluate the occurrence of DEL in 177 SBC cases and in 169 controls, and compare clinical and biological characteristics. A lower frequency of GSTM1 DEL was observed in mulatto women, OR=0.48 (0.24–0.98. The risk of nuclear grade 3 tumors (GN3 was lower in patients with GSTT1 DEL, OR=0.37 (0.15–0.90. DEL of at least one gene (ALOG was associated with women who had not breastfed, OR=0.41 (0.19–0.88, and with negative hormone receptor, HR–, ORadj=2.25 (1.03–4.90. Both genes deleted (BGD was associated with non-classic invasive ductal carcinoma (NCDC, ORadj=12.09 (1.03–142.03. Mulatto women with SBC had a lower frequency of GSTM1 DEL, while tumors differentiated were related to GSTT1 DEL. HRtumors were related with DEL ALOG, and the BGD was associated with a greater risk of NCDC.

  11. Feline cutaneous neuroendocrine carcinoma (Merkel cell tumour): clinical and pathological findings.

    Science.gov (United States)

    Bagnasco, Giorgio; Properzi, Roberto; Porto, Roberto; Nardini, Vincenzo; Poli, Alessandro; Abramo, Francesca

    2003-04-01

    A case of a feline Merkel cell tumour is described. An 8-year-old, female cat developed a round, alopecic, reddish mass on the nose. Wide excisional surgery was performed with cartilage resection. Histologically the mass was composed of solid islands of mostly basophilic densely packed cells with a scant cytoplasm, which was suggestive of a neuroendocrine origin. Results of immunohistochemical studies using antibodies against neurone-specific enolase, chromogranin, synaptophysin and pan-cytokeratin allowed classification of the lesion as a Merkel cell tumour. Ultrastructurally, dense core granules were identified in the cytoplasm. In a 2-year follow-up no relapses or metastases were observed. The clinical course recorded is in contrast with the malignant nature of a Merkel cell tumour recently described in a cat and of the human Merkel cell tumour, but is similar to the course of the canine Merkel cell tumour which is often benign. Early diagnosis along with the use of wide surgical excision might be considered an important factor in preventing relapse of this tumour. PMID:12662269

  12. Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology

    International Nuclear Information System (INIS)

    To analyze the clinical application of endoscope with narrow-band imaging (NBI) system in detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral erythroplakia. The demographic, histopathological data, and NBI vasculature architectures of patients receiving surgical intervention for oral erythroplakia were retrospectively reviewed and analyzed statistically. A total of 72 patients, including 66 males and 6 females, with mean age of 54.6 ± 11.2 years, were enrolled. The odds ratio of detecting high-grade dysplasia, carcinoma in situ, and carcinoma by twisted elongated morphology and destructive pattern of intraepithelial microvasculature was 15.46 (confidence interval 95 %: 3.81–72.84), and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80.95 %, 78.43 %, 60.71 %, 90.91 %, and 79.17 %, respectively, which were significantly better than other two established NBI criteria (p < 0.001). Twisted, elongated, and destructive patterns of intraepithelial papillary capillary loop of NBI images are indicators for high-grade dysplasia, carcinoma in situ, and invasive carcinoma in oral erythroplakia

  13. The Role of Neurotrophins in Multiple Sclerosis—Pathological and Clinical Implications

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    Alicja Kalinowska-Lyszczarz

    2012-10-01

    Full Text Available Multiple sclerosis (MS is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS with unknown etiology. It was recently suggested that autoimmunity, which had long been considered to be destructive in MS, might also play a protective role in the CNS of MS patients. Neurotrophins are polypeptides belonging to the neurotrophic factor family. While neurotrophins mediate cell survival and proliferation in the nervous system, they are also expressed within peripheral blood mononuclear cells fraction (PBMCs of immunological system. In MS additional neurotrophic support from PBMCs might compensate relative neurotrophins deficiency in the damaged CNS tissue that needs to be repaired. Failure to produce the adequate neurotrophins concentrations might result in decreased protection of the CNS, consequently leading to increased atrophy, which is the main determinant of MS patients’ end-point disability. There are several lines of evidence, both from clinical research and animal models, suggesting that neurotrophins play a pivotal role in neuroprotective and neuroregenerative processes that are often defective in the course of MS. It seems that neuroprotective strategies might be used as potentially valuable add-on therapies, alongside traditional immunomodulatory treatment in multiple sclerosis.

  14. Tubercular meningitis in children: Clinical, pathological, and radiological profile and factors associated with mortality

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    Anil V Israni

    2016-01-01

    Full Text Available Context: Childhood tuberculosis is a major public health problem in developing countries with tubercular meningitis being a serious complication with high mortality and morbidity. Aim: To study the clinicopathological as well as radiological profile of childhood tuberculous meningitis (TBM cases. Settings and Design: Prospective, observational study including children <14 years of age with TBM admitted in a tertiary care hospital from Western India. Subjects and Methods: TBM was diagnosed based on predefined criteria. Glassgow coma scale (GCS and intracranial pressure (ICP was recorded. Staging was done as per British Medical Council Staging System. Mantoux test, chest X-ray, cerebrospinal fluid (CSF examination, neuroimaging, and other investigations were done to confirm TB. Statistical Analysis Used: STATA software (version 9.0 was used for data analysis. Various risk factors were determined using Chi-square tests, and a P< 0.05 was considered significant. Results: Forty-seven children were included, of which 11 (24.3% died. Fever was the most common presenting symptom, and meningismus was the most common sign. Twenty-nine (62% children presented with Stage III disease. Stage III disease, low GCS, and raised ICP were predictors of mortality. Findings on neuroimaging or CSF examination did not predict mortality. Conclusions: Childhood TBM presents with nonspecific clinical features. Stage III disease, low GCS, lack of Bacillus Calmette–Gu͹rin vaccination at birth and raised ICP seem to the most important adverse prognostic factors.

  15. Tubercular meningitis in children: Clinical, pathological, and radiological profile and factors associated with mortality

    Science.gov (United States)

    Israni, Anil V.; Dave, Divya A.; Mandal, Anirban; Singh, Amitabh; Sahi, Puneet K.; Das, Rashmi Ranjan; Shah, Arpita

    2016-01-01

    Context: Childhood tuberculosis is a major public health problem in developing countries with tubercular meningitis being a serious complication with high mortality and morbidity. Aim: To study the clinicopathological as well as radiological profile of childhood tuberculous meningitis (TBM) cases. Settings and Design: Prospective, observational study including children <14 years of age with TBM admitted in a tertiary care hospital from Western India. Subjects and Methods: TBM was diagnosed based on predefined criteria. Glassgow coma scale (GCS) and intracranial pressure (ICP) was recorded. Staging was done as per British Medical Council Staging System. Mantoux test, chest X-ray, cerebrospinal fluid (CSF) examination, neuroimaging, and other investigations were done to confirm TB. Statistical Analysis Used: STATA software (version 9.0) was used for data analysis. Various risk factors were determined using Chi-square tests, and a P< 0.05 was considered significant. Results: Forty-seven children were included, of which 11 (24.3%) died. Fever was the most common presenting symptom, and meningismus was the most common sign. Twenty-nine (62%) children presented with Stage III disease. Stage III disease, low GCS, and raised ICP were predictors of mortality. Findings on neuroimaging or CSF examination did not predict mortality. Conclusions: Childhood TBM presents with nonspecific clinical features. Stage III disease, low GCS, lack of Bacillus Calmette–Guérin vaccination at birth and raised ICP seem to the most important adverse prognostic factors. PMID:27365958

  16. Hepatic adenoma and focal nodular hyperplasia: clinical, pathologic, and radiologic features

    International Nuclear Information System (INIS)

    Based on strict predefined histologic criteria, we identified 23 patients with hepatic adenoma and 41 patients with focal nodular hyperplasia seen at this institution between 1961 and 1980. Patients with hepatic adenoma were young and 91% were female. When a reliable history was available, 89% had used oral contraceptives; 53% presented acutely or with pain. Eleven of 11 radionuclide scans were abnormal; 15 of 15 angiograms showed a hypervascular mass with 7 of 15 showing areas of hypovascularity. Eighteen resections were performed with one operative death. Two tumors contained areas of unequivocal hepatocellular carcinoma. Fifteen of 18 patients followed for 82 +/- 11 mo were living and well and had discontinued oral contraceptives. Focal nodular hyperplasia patients were older, 88% were female, and 58% had used oral contraceptives. Their lesions were discovered accidentally. Seven of 12 radionuclide scans demonstrated voids, while 13 of 13 angiograms showed hypervascular lesions with no areas of hypovascularity. Seventeen tumors were resected. Twenty-three of 24 patients followed for 45 +/- 7 mo were living and well. One died of nonhepatic causes. Based on the findings of this review, we believe that if the clinical suspicion of hepatic adenoma or focal nodular hyperplasia is strong, elective laparotomy for diagnosis is usually the best approach. Hepatic adenoma should be resected if technically feasible. Intraoperative wedge biopsy is appropriate for focal nodular hyperplasia

  17. A STUDY OF CLINICAL, PATHOLOGICAL AND BIOCHEMICAL FINDINGS IN PATIENTS WHO ATTEMPTED SUICIDE BY HAIR DYE SUPERVASMOL 33 INGESTION

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    Sudheer Babu

    2015-06-01

    Full Text Available BACKGROUND : All the patient in the study consumed the hair dye available in the market with the trade name Supervasmol 33. The prevalence of Super vasmol 33 hair dye poisoning has been on a surge for the past 2 - 3 years as has been observed by the increase in number of cases being admitted into the hospitals. It was observed that the tendency of poisoning by Super vasmol 33 hair dye was more in females than in males and was more in the age group of 15 - 35 years, as with any other poisoning. METERIALS AND METHODS: Study of Clinical, pathological and biochemical findings in patients who attempted suicide by hair dye ingestion (Supervasmol 3 who were admitted in Government General Hospital/Guntur medical college, Guntur during June 2013 to March 2015 brought to emergency department and those who were admitted into the HDU, ICU and medical wards of the hospital, after the following exclusion criteria were ruled out. RESULTS: A significant statistical correlation was found to exist between development of AKI and the levels of CPK in blood, rhabdomyolysis and hyperkalemia. The morbidity rates were 100% for angioedema, 58% for rhabdomyolysis and 32% for acute kidney injury (AKI. Institutional mortality rate was about 8% due to refractory hemodynamic shock. CONCLUSION: As the burden of handling Supervasmol 33 hair dye poisoning cases has been recently increasing, primary care physicians, intensive care physicians and nephrologists need to be aware of its clinical manifestation and management

  18. Clinical and Pathological Findings in Green Turtles (Chelonia mydas) from Gladstone, Queensland: Investigations of a Stranding Epidemic.

    Science.gov (United States)

    Flint, Mark; Eden, Paul A; Limpus, Colin J; Owen, Helen; Gaus, Caroline; Mills, Paul C

    2015-06-01

    An investigation into the health of green turtles was undertaken near Gladstone, Queensland, in response to a dramatic increase in stranding numbers in the first half of 2011. A total of 56 live turtles were subject to clinical examination and blood sampling for routine blood profiles, and 12 deceased turtles underwent a thorough necropsy examination. This population of green turtles was found to be in poor body condition and a range of infectious and non-infectious conditions were identified in the unhealthy turtles, including hepato-renal insufficiency (up to 81%, 27/33 based on clinical pathology), cachexia (92%, 11/12), parasitism (75%, 9/12), cardiopulmonary anomalies (42%, 5/12), gastroenteritis (25%, 3/12), masses (25%, 3/12) and mechanical impediments (17%, 2/12 based on necropsy). Overall, there was no evidence to indicate a unifying disease as a primary cause of the mass mortality. Recent adverse weather events, historic regional contamination and nearby industrial activities are discussed as potential causative factors. PMID:25256011

  19. Atypical antipsychotics in the treatment of pathological aggression in children and adolescents: literature review and clinical recommendations

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    Eduardo Henrique Teixeira

    2013-01-01

    Full Text Available Objective: To review the literature about the use of atypical antipsychotics in the treatment of pathological aggression in children and adolescents. Method: The databases MEDLINE, SciELO, and LILACS were searched for publications in Portuguese or English from 1992 to August 2011 using the following keywords: mental disease, child, adolescent, treatment, atypical antipsychotic, aggressive behavior, aggression, and violent behavior. Results: Sixty-seven studies of good methodological quality and clinical interest and relevance were identified. Studies including children and adolescents were relatively limited, because few atypical antipsychotics have been approved by the Food and Drug Administration (FDA. All the medications included in this review (risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole and clozapine have some effectiveness in treating aggression in children and adolescents, and choices should be based on clinical indications and side effects. Conclusions: There are few studies about the effectiveness and safety of atypical antipsychotics for the pediatric population, and further randomized controlled studies with larger groups of patients and more diagnostic categories, such as severe conduct disorder and oppositional defiant disorder, should be conducted to confirm the results reported up to date and to evaluate the impact of long-term use.

  20. Clinical and pathological features and surgical treatment of Budd-Chiari syndrome-associated hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    WANG Ya-dong; XUE Huan-zhou; ZHANG Xiao; XU Zong-quan; JIANG Qing-feng; SHEN Quan; YU Miao

    2013-01-01

    Background Budd-Chiari syndrome (BCS) is characterized by liver sinusoidal congestion,ischemic liver cell damage,and liver portal hypertension caused by hepatic venous outflow constriction.The aim of this research was to investigate the clinicopathological features of BCS-associated hepatocellular carcinoma (HCC) and explore its surgical treatment and prognosis.Methods Clinical data from 38 patients with BCS-associated HCC who were surgically treated in our hospital from July 1998 to August 2010 were retrospectively analyzed.The clinicopathological features and prognosis of patients with BCS-associated HCC and surgical treatment for BCS-associated HCC were investigated.Results Compared to the patients with hepatitis B virus (HBV)-associated HCC,the patients with BCS-associated HCC showed a female predominance,and had significantly higher cirrhosis rate,higher incidence of solitary tumors,lower incidence of infiltrative growth,higher proportion of marginal or exogenous growth,lower rate of portal vein invasion,and higher degree of differentiation.Median survival was longer in patients with BCS-associated HCC (76 months) than in those with HBV associated HCC (38 months).Of 38 patients with BCS-associated HCC,22 patients who received combined surgery mainly by liver resection plus cavoatrial shunts exhibited hepatic venous outflow constriction relief,while the other 16 patients only underwent liver resection.The combined surgery group had significantly longer survival and lower incidences of post-operative lethal complications (P <0.05).Multivariate analysis showed that relief of hepatic venous outflow obstruction was a protective factor for survival of patients with BCS-associated HCC,whereas portal vein invasion was a risk factor.Conclusions BCS-associated HCC has a more favorable biological behavior and prognosis than HBV-associated HCC.For patients with BCS-associated HCC,tumor resection accompanied with relief of hepatic venous outflow obstruction can reduce

  1. Subclinical myopathy in patients with colorectal cancer: clinical-pathological characterization and search for tissue markers

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    Massimo Vecchiato

    2012-03-01

    Full Text Available Skeletal muscle in patients with cancer undergoes many morphological changes due to immuno-inflammatory factors of tumor origin or treatment.T he latest event of these changes is cancer cachexia. Aim of the study is to identify myopathic features in skeletal muscle biopsies from weight stable patients with colorectal cancer and without cachexia or asthenia / weakness, that could possibly provide new diagnostic and prognostic cancer biomarkers. Morphometric analyses and immunohistochemical studies were performed on intraoperative muscle biopsies from patients with colorectal cancer and from weight stable patients undergoing surgery for benign non-inflammatory conditions. A rectus abdominis biopsy was taken in all patients and controls.A correlation between histopathologic findings and clinical characteristics, circulating inflammatory biomarkers and markers of muscle necrosis,surgery data and cancer phenotype were investigated.. Forty four patients (21male/23 female and 17 controls (6 male/11 female (p=NS were studied. In cancer patients’biopsies we observed asubclinical myopathy characterized by an abnormal distribution of myonuclei, which are localized inside the myofiber rather than at the periphery, and by the presence of regenerating muscle fibers. The percentage of myofibers with internalized nuclei is significantly higher in patients (median= 9%, IQR= 3.7-18.8 than in controls (median= 2.7%, IQR= 1.7-3.2 ( p=0.0002. In patients we observed an inverse correlation between the number of centronucleated fibers and the presence of node metastasis (N+(ρ=-0.64 (p=0.002. Patients affected with colorectal cancer display early sign of a myopathy, characterized by centronucleated and regenerating myofibers. This myopathy appears to be associated with an early stage of neoplasia and it could be an adaptive response of muscle to cancer. We hope a future application of these findings as a possible early diagnostic and prognostic biomarker of

  2. Bilateral breast carcinoma after Hodgkin's disease. Clinical and pathological characteristics: analysis of 13 cases

    International Nuclear Information System (INIS)

    treatment for HD, using clinical examination, mammography and ultrasonography. The optimal rhythm of this follow-up is not yet clearly defined. (authors)

  3. Does Tenascin have Clinical Implications in Pathological Grade of Glioma Patients?

    Science.gov (United States)

    Kong, Xiangyi; Ma, Wenbin; Li, Yongning; Wang, Yu; Guan, Jian; Gao, Jun; Wei, Junji; Yao, Yong; Lian, Wei; Xu, Zhiqin; Dou, Wanchen; Xing, Bing; Ren, Zuyuan; Su, Changbao; Yang, Yi; Wang, Renzhi

    2015-01-01

    Abstract Tenascin (TN) is an extracellular oligomeric glycoprotein that participates in the adhesion of cells to extracellular matrixc (ECM). Studies have shown that the expression levels of TN are upregulated in a variety of cancers, including colon cancer, lung cancer, brain tumor, and breast cancer. However, the implications and utilities of TN in clinical grading and prognosis of glioma patients were seldom reported and the effects of its pathway are still unclear and controversial. Thus, it is essential to carry out a meta-analysis to draw a convincing conclusion. A literature search was carried out up to April 2015. Data was collected using a purpose-designed form including glioma's WHO grade, etc. Differences were expressed as odds ratios (ORs) or standard mean differences (SMDs) with 95% confidence intervals (CIs). Galbr figure, Cochran's Q test, and I2 test were all performed to judge the heterogeneity between included studies. To examine the stability of the pooled results, a sensitivity analysis was performed. Potential publication bias was assessed by visual inspection of funnel plot. As this meta-analysis, as a systematic review, does not involve animal experiments or direct human trials, there is no need to conduct special ethic review and the ethical approval is not necessary. In this meta-analysis, 8 eligible studies involving 456 patients were incorporated. Six studies with dichotomous data revealed TN overexpression in glioma tissues and/or surrounding neoplastic vessels was closely associated with high WHO grade (III + IV) (odds ratio 3.398, 95% confidence interval 1.933, 5.974; P = 0.000); three continuous data studies showed there were close statistical associations between TN and WHO grade (SMD −2.114, 95% CI −2.580, −1.649; P = 0.000) too. Sensitivity analysis indicated a statistically robust result. No publication bias was revealed. Our meta-analysis suggests that TN expression is potentially associated with higher WHO

  4. The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer: A Report of the Association for Molecular Pathology.

    Science.gov (United States)

    Joseph, Loren; Cankovic, Milena; Caughron, Samuel; Chandra, Pranil; Emmadi, Rajyasree; Hagenkord, Jill; Hallam, Stephanie; Jewell, Kay E; Klein, Roger D; Pratt, Victoria M; Rothberg, Paul G; Temple-Smolkin, Robyn L; Lyon, Elaine

    2016-09-01

    Clinical utility describes the benefits of each laboratory test for that patient. Many stakeholders have adopted narrow definitions for the clinical utility of molecular testing as applied to targeted pharmacotherapy in oncology, regardless of the population tested or the purpose of the testing. This definition does not address all of the important applications of molecular diagnostic testing. Definitions consistent with a patient-centered approach emphasize and recognize that a clinical test result's utility depends on the context in which it is used and are particularly relevant to molecular diagnostic testing because of the nature of the information they provide. Debates surrounding levels and types of evidence needed to properly evaluate the clinical value of molecular diagnostics are increasingly important because the growing body of knowledge, stemming from the increase of genomic medicine, provides many new opportunities for molecular testing to improve health care. We address the challenges in defining the clinical utility of molecular diagnostics for inherited diseases or cancer and provide assessment recommendations. Starting with a modified analytic validity, clinical validity, clinical utility, and ethical, legal, and social implications model for addressing clinical utility of molecular diagnostics with a variety of testing purposes, we recommend promotion of patient-centered definitions of clinical utility that appropriately recognize the valuable contribution of molecular diagnostic testing to improve patient care. PMID:27542512

  5. Detection of riboflavin contents in plasma and tumor tissues of patients with esophageal carcinoma and its clinical pathological significance evaluation

    Institute of Scientific and Technical Information of China (English)

    Yong Wu; Nan-Bin Yu

    2016-01-01

    Objective:To study the riboflavin contents in plasma and tumor tissues of patients with esophageal carcinoma and its clinical pathological significance.Methods:Serum samples of healthy volunteers and serum and tissue specimens of patients with esophageal cancer were collected. And riboflavin contents in them were detected. Lsm-4, Bmi-1, Galectin-7, PAR-2, Yap1, nestin, MBP-1, IKK16, beclin-1, RIP-1, DEC-1 and LAST-1 contents in tissue samples were also detected.Results:riboflavin contents in esophageal carcinoma patients’ serum and esophageal cancer tissue were significantly lower than those of healthy volunteers. Lsm-4, Bmi-1, Galectin-7, PAR-2, Yap1 and Nestin contents in esophageal cancer tissue were significantly higher than those in normal tissue. The lower the content of riboflavin in esophageal cancer tissue was, the higher the contents of Lsm-4, Bmi-1, Galectin-7, PAR-2, Yap1 and Nestin were. In esophageal cancer tissue, MBP-1, IKK16, beclin-1, RIP-1, DEC-1 and LAST-1 contents were significantly lower than those in normal tissue, and the lower the content of riboflavin in esophageal cancer tissue, the lower the MBP-1, IKK16, beclin-1, RIP-1, DEC-1, LAST-1 contents.Conclusions:riboflavin contents in plasma and tumor tissues of esophageal cancer patients abnormally decrease and the more obvious the decrease of its content, the higher the proliferation-promoting gene contents, and the lower the proliferation-inhibiting gene contents.

  6. Pathological and Clinical Features and Management of Central Nervous System Hemangioblastomas in von Hippel-Lindau Disease

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    Hiroshi Kanno

    2014-08-01

    Full Text Available Central nervous system (CNS hemangioblastoma is the most common manifestation of von Hippel-Lindau (VHL disease. It is found in 70-80% of VHL patients. Hemangioblastoma is a rare form of benign vascular tumor of the CNS, accounting for 2.0% of CNS tumors. It can occur sporadically or as a familial syndrome. CNS hemangioblastomas are typically located in the posterior fossa and the spinal cord. VHL patients usually develop a CNS hemangioblastoma at an early age. Therefore, they require a special routine for diagnosis, treatment and follow-up. The surgical management of symptomatic tumors depends on many factors such as symptom, location, multiplicity, and progression of the tumor. The management of asymptomatic tumors in VHL patients is controversial since CNS hemangioblastomas grow with intermittent quiescent and rapid-growth phases. Preoperative embolization of large solid hemangioblastomas prevents perioperative hemorrhage but is not necessary in every case. Radiotherapy should be reserved for inoperable tumors. Because of complexities of VHL, a better understanding of the pathological and clinical features of hemangioblastoma in VHL is essential for its proper management.

  7. Image processing for the rest of us: the potential utility of inexpensive computerized image analysis in clinical pathology and radiology.

    Science.gov (United States)

    McEachron, D L; Hess, S; Knecht, L B; True, L D

    1989-01-01

    Recent progress in computer technology in both hardware and software, combined with marked cost reductions, have placed quantitatively accurate video densitometry systems within the reach of the individual clinician, biomedical researcher, and community hospital. While much of the attention generated by advances in image processing has focussed on larger scale procedures, such as CAT, chemical shift, and positron emission tomography, important applications can be found for considerably more modest systems. In this article, we discuss three such applications of DUMAS, a personal computer-based imaging system developed by the Image Processing Center at Drexel University. A potential technique for quantifying numbers of estrogen receptors in tumorous breast tissue samples as a predictor of patient responsiveness to hormonal therapy is described first, along with possible sources of error. The second application, also related to clinical pathology and cancer, outlines methods for relating changes in nuclear and cell morphology to the diagnosis of Sezary Cell Syndrome. The utility of binary image filtering methods in the classification of cell types is discussed. The third application involves the development of a semi-automatic procedure for the determination of vessel diameter in arteriograms. A detailed description of the optimization and curve-fitting algorithms is provided along with preliminary test results comparing various approaches. The need for user demand to fuel research and development in small-scale imaging systems is also discussed. PMID:2647281

  8. 2D and 3D Refraction Based X-ray Imaging Suitable for Clinical and Pathological Diagnosis

    Science.gov (United States)

    Ando, Masami; Bando, Hiroko; Chen, Zhihua; Chikaura, Yoshinori; Choi, Chang-Hyuk; Endo, Tokiko; Esumi, Hiroyasu; Gang, Li; Hashimoto, Eiko; Hirano, Keiichi; Hyodo, Kazuyuki; Ichihara, Shu; Jheon, SangHoon; Kim, HongTae; Kim, JongKi; Kimura, Tatsuro; Lee, ChangHyun; Maksimenko, Anton; Ohbayashi, Chiho; Park, SungHwan; Shimao, Daisuke; Sugiyama, Hiroshi; Tang, Jintian; Ueno, Ei; Yamasaki, Katsuhito; Yuasa, Tetsuya

    2007-01-01

    The first observation of micro papillary (MP) breast cancer by x-ray dark-field imaging (XDFI) and the first observation of the 3D x-ray internal structure of another breast cancer, ductal carcinoma in-situ (DCIS), are reported. The specimen size for the sheet-shaped MP was 26 mm × 22 mm × 2.8 mm, and that for the rod-shaped DCIS was 3.6 mm in diameter and 4.7 mm in height. The experiment was performed at the Photon Factory, KEK: High Energy Accelerator Research Organization. We achieved a high-contrast x-ray image by adopting a thickness-controlled transmission-type angular analyzer that allows only refraction components from the object for 2D imaging. This provides a high-contrast image of cancer-cell nests, cancer cells and stroma. For x-ray 3D imaging, a new algorithm due to the refraction for x-ray CT was created. The angular information was acquired by x-ray optics diffraction-enhanced imaging (DEI). The number of data was 900 for each reconstruction. A reconstructed CT image may include ductus lactiferi, micro calcification and the breast gland. This modality has the possibility to open up a new clinical and pathological diagnosis using x-ray, offering more precise inspection and detection of early signs of breast cancer.

  9. 18F-Fluorodeoxyglucose Positron Emission Tomography for Primary Thyroid Cancer: Correlation with the Clinical, Pathologic and Sonographic Findings

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    Kim, Kyung Eun; Kim, Eun Kyung; Moon, Hee Jung; Kwak, Jin Young [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2011-06-15

    We wanted to investigate the incidence and the clinicopathologic and sonographic characteristics of thyroid cancers that exhibit positive PET scans. From January 2007 to February 2008, 156 patients with thyroid cancer underwent both sonography and FDG-PET for the purpose of staging the cancer. We conducted a retrospective review of their clinical, radiologic and pathologic records and we evaluated the incidence of PET-positive thyroid cancer, as well as the associated clinicopathologic aggressiveness and the sonographic features. The incidence of PET-positive thyroid carcinoma was 78.2% (122/156). On univariate analysis, PET-positive thyroid cancer was significantly associated with tumor size, extracapsular invasion and central lymph node metastasis, but there was no association between the sonographic features of the thyroid cancer or the sonographic features of the 2 groups of tumor (1. probably benign and 2. suspicious for malignancy) and the FDG uptake. Multivariate logistic regression analysis showed a significant association between PET positivity and both extrathyroidal extension and a higher cancer stage (III/IV) (p < 0.05). The incidence of PET positive thyroid carcinoma is high (78.2%) and PET positivity is significantly associated with tumor size, extracapsular extension and a higher stage. However, there is no significant association between PET positivity and the sonographic features of thyroid carcinoma

  10. STUDY ON THE CLINICAL-PATHOLOGICAL SIGNIFICANCE OF MICROVESSEL DENSITY AND VASCULAR ENDOTHILIAL GROWTH FACTOR EXPRESSION IN PRIMARY LIVER CANCER

    Institute of Scientific and Technical Information of China (English)

    XIA Jing-lin; YANG Bing-hui; YE Sheng-long; LIN Zhi-ying; MA Zeng-chen; ZHOU Xin-da; WU Zhi-quan; TANG Zhao-you

    1999-01-01

    Objective: To evaluate the clinical-pathological significance of intratumoral microvessel density (MVD) and Vascular Endothelial Growth Factor (VEGF) expression in primary liver cancer (PLC). Methods: A retrospective study from 63 postoperative patients all with small PLC (diameter ≤ 5 cm) was done. One group of 29 patients developed recurrence or metastasis within 2 years. The other group of 34 patients had no evidence of recurrence or metastasis within 2 years. Three sections were taken from each patient. One for H.E. staining, the other two for VEGF and Bio-UEA-Ⅰ immunohistochemical staining respectively.MVD was counted by endothelial cells, which were highlighted by Bio-UEA-Ⅰ. Results: The MVD of the recurrence (or metastasis) group (49.6±29.7) were significantly greater than the other group (22.7±28.2) (P<0.01); The VEGF positive rate of the recurrence group was 86.2% (25/29), the rate of the other group was 47.1% (16/34). The difference between the 2 groups was stafistically significant (P<0.01). The stage of the tumor, the positive rate of satellite nodules and the positive rate of the portal vein embolus were all significantly different between the 2 groups. Conclusion: Besides tumor stage, satellite nodule and portal vein embolus, the MVD and VEGF are also of prognostic significance.

  11. 2D and 3D Refraction Based X-ray Imaging Suitable for Clinical and Pathological Diagnosis

    International Nuclear Information System (INIS)

    The first observation of micro papillary (MP) breast cancer by x-ray dark-field imaging (XDFI) and the first observation of the 3D x-ray internal structure of another breast cancer, ductal carcinoma in-situ (DCIS), are reported. The specimen size for the sheet-shaped MP was 26 mm x 22 mm x 2.8 mm, and that for the rod-shaped DCIS was 3.6 mm in diameter and 4.7 mm in height. The experiment was performed at the Photon Factory, KEK: High Energy Accelerator Research Organization. We achieved a high-contrast x-ray image by adopting a thickness-controlled transmission-type angular analyzer that allows only refraction components from the object for 2D imaging. This provides a high-contrast image of cancer-cell nests, cancer cells and stroma. For x-ray 3D imaging, a new algorithm due to the refraction for x-ray CT was created. The angular information was acquired by x-ray optics diffraction-enhanced imaging (DEI). The number of data was 900 for each reconstruction. A reconstructed CT image may include ductus lactiferi, micro calcification and the breast gland. This modality has the possibility to open up a new clinical and pathological diagnosis using x-ray, offering more precise inspection and detection of early signs of breast cancer

  12. Serum high mobility group box-1 (HMGB1 is closely associated with the clinical and pathologic features of gastric cancer

    Directory of Open Access Journals (Sweden)

    Chung Jae

    2009-05-01

    Full Text Available Abstract Background High mobility group box-1 (HMGB1 is a newly recognized factor regulating cancer cell tumorigenesis, expansion and invasion. We investigated the correlation between the serum HMGB1 levels and the clinical and pathologic features of gastric cancer and evaluated the validity of HMGB1 as a potential biomarker for the early diagnosis of gastric cancer. Methods A total of 227 subjects were classified into 5 disease groups according to the 'gastritis-dysplasia-carcinoma' sequence of gastric carcinogenesis and their serum levels of HMGB1 were analyzed by an enzyme-linked immunosorbent assay (ELISA method. Clinical parameters, International Union Against Cancer (UICC TNM stage, cancer size, differentiation or lymphatic invasion, vascular or perineural invasion and prognosis were used as analysis variables. Results The serum HMGB1 levels were significantly different among disease groups (ANOVA, p and HMGB1 levels tended to increase according to the progression of gastric carcinogenesis. Serum HMGB1 levels were significantly associated with depth of invasion, lymph node metastasis, tumor size, and poor prognosis (p . However, HMGB1 levels were not associated with patient gender or age, differentiation of tumor cells, or lymphatic, vascular and perineural invasion, or the existence of distant metastasis in advanced cancer (p > 0.05. The sensitivity and specificity of serum HMGB1 was 71% and 67% (cut-off value of 5 ng/ml for the diagnosis of early gastric cancer, and 70% and 64% (cut-off value of 4 ng/ml for the diagnosis of high-risk lesions, respectively. These values were greater than those for carcinoembryonic antigen (CEA (30–40% of sensitivity. Conclusion HMGB1 appears to be a useful serological biomarker for early diagnosis as well as evaluating the tumorigenesis, stage, and prognosis of gastric cancer.

  13. Clinical pathology of alcohol.

    OpenAIRE

    Marks, V.

    1983-01-01

    There is good though not conclusive evidence that a small to modest average daily intake of alcohol--that is, 20-30 g/day is associated with increased longevity due mainly to a reduction in death from cardiovascular disease. Larger average daily alcohol intakes--especially those in excess of 60 g/day for men and 40 g/day for women--are associated with gradually increasing morbidity and mortality rates from a variety of diseases. Alcohol may be unrecognised as the cause of somatic disease, whi...

  14. Diffusion-weighted MR imaging of liver pathology: principles and clinical applications; Imagerie par resonance magnetique de diffusion (IRMD) en pathologie hepatique: principe et applications cliniques

    Energy Technology Data Exchange (ETDEWEB)

    Lewin, M.; Arrive, L.; Lacombe, C.; Azizi, L.; Raynal, M.; Jomaah, N.; Monnier-Cholley, L.; Tubiana, J.M.; Menu, Y. [Hopital Saint-Antoine, Assistance Publique - Hopitaux de Paris, Service de Radiologie, 75 - Paris (France); Lewin, M.; Arrive, L.; Tubiana, J.M.; Menu, Y. [Paris-6 Univ. Pierre et Marie Curie, Faculte de medecine Saint-Antoine, 75 - Paris (France); Vignaud, A. [Siemens medical department, Saint-Denis, 93 (France)

    2010-01-15

    Due to ongoing technological advances, the range of clinical applications for diffusion-weighted MR imaging has expanded to now include abdominal pathology. Current applications for liver pathology include two main directions. First, oncologic imaging with detection, characterization and follow-up of lesions. Second, evaluation of diffuse liver diseases, including hepatic fibrosis. The diagnostic impact and role of diffusion-weighted MR imaging remain under investigation, but appear promising. Because of its short acquisition time, sensitivity, and additional information it provides, diffusion-weighted MR imaging should be included in routine liver imaging protocols. (authors)

  15. Pathological Internet use and psychiatric disorders: A cross-sectional study on psychiatric phenomenology and clinical relevance of Internet dependency

    Directory of Open Access Journals (Sweden)

    Bert Theodor te Wildt

    2010-09-01

    Full Text Available Background and Objectives: With the Cyberspace´s exponential growth of influence questions arise about its mental impacts. The presented study examines the question whether the dependent use of the Internet can be understood as an impulse control disorder, an addiction or as a symptom of other psychiatric conditions. Methods: Internet dependent patients seeking for psychiatric assistance and fulfilling the criteria for pathological Internet use (PIU were examined with the Structured Clinical Interview according to DSM-IV (SCID, and a variety of questionnaires including the Barratt Impulsiveness Scale (BIS, the Beck Depression Inventory (BDI and the Dissociative Experience Scale (DES. The patient group was compared to a matched group of healthy controls. Results: The adult patient-group consisted of 25 subjects, 76% male, with a mean age of 29.36 years. Average time spent in Cyberspace was 6.47 h/d, mostly in online-role-playing games. According to SCID I and BDI, 19 patients (76% suffered from a depressive syndrome, with 10 cases of major depressive disorder (40% and 8 cases of adjustment disorder with depression (32%. Six patients (24% suffered from a comorbid anxiety disorder. Compared to controls, the patient group presented significantly higher levels of depression (BDI, impulsivity (BIS and dissociation (DES. Conclusions: PIU shares common psychopathological features and comorbidities with substance related disorders. Therefore, it might be seen as a diagnostic entity in itself in a spectrum of behavioural and substance dependencies. Especially Internet role play may contain an addictive potential for adolescents and adults with subclinical psychopathology.

  16. Assessment of clinical pathology and pathogen exposure in sea otters (Enhydra lutris) bordering the threatened population in Alaska

    Science.gov (United States)

    Goldstein, T.; Gill, V.A.; Tuomi, P.; Monson, D.; Burdin, A.; Conrad, P.A.; Dunn, J.L.; Field, C.; Johnson, Chad; Jessup, David A.; Bodkin, J.; Doroff, A.M.

    2011-01-01

    Northern sea otter (Enhydra lutris kenyoni) abundance has decreased dramatically over portions of southwest Alaska, USA, since the mid-1980s, and this stock is currently listed as threatened under the Endangered Species Act. In contrast, adjacent populations in south central Alaska, USA, and Russia have been stable to increasing during the same period. Sea otters bordering the area classified in the recent decline were live-captured during 2004-2006 at Bering Island, Russia, and the Kodiak Archipelago, Alaska, USA, to evaluate differences in general health and current exposure status to marine and terrestrial pathogens. Although body condition was lower in animals captured at Bering Island, Russia, than it was at Kodiak, USA, clinical pathology values did not reveal differences in general health between the two regions. Low prevalences of antibodies (,5%) were found in Kodiak, USA, and on Bering Island, Russia, to Toxoplasmagondii, Sarcocystis neurona, and Leptospira interrogans. Exposure to phocine herpesvirus-1 was found in both Kodiak, USA (15.2%), and Bering Island, Russia (2.3%). Antibodies to Brucella spp. were found in 28% of the otters tested on Bering Island, Russia, compared with only 2.7% of the samples from Kodiak, USA. Prevalence of exposure to Phocine distemper virus (PDV) was 41% in Kodiak, USA, but 0% on Bering Island, Russia. Archived sera from southwest and south-central Alaska dating back to 1989 were negative for PDV, indicating exposure occurred in sea otters in Kodiak, USA, in recent years. Because PDV can be highly pathogenic in nai{dotless}??ve and susceptible marine mammal populations, tissues should be examined to explore the contribution of this virusto otter deaths. Our results reveal an increase in exposure to pathogens in sea otters in Kodiak,Alaska, USA, since the 1990s. ?? Wildlife Disease Association 2011.

  17. Assessment of clinical pathology and pathogen exposure in sea otters (Enhydra lutris) bordering the threatened population in Alaska.

    Science.gov (United States)

    Goldstein, Tracey; Gill, Verena A; Tuomi, Pam; Monson, Daniel; Burdin, Alexander; Conrad, Patricia A; Dunn, J Lawrence; Field, Cara; Johnson, Christine; Jessup, David A; Bodkin, James; Doroff, Angela M

    2011-07-01

    Northern sea otter (Enhydra lutris kenyoni) abundance has decreased dramatically over portions of southwest Alaska, USA, since the mid-1980s, and this stock is currently listed as threatened under the Endangered Species Act. In contrast, adjacent populations in south central Alaska, USA, and Russia have been stable to increasing during the same period. Sea otters bordering the area classified in the recent decline were live-captured during 2004-2006 at Bering Island, Russia, and the Kodiak Archipelago, Alaska, USA, to evaluate differences in general health and current exposure status to marine and terrestrial pathogens. Although body condition was lower in animals captured at Bering Island, Russia, than it was at Kodiak, USA, clinical pathology values did not reveal differences in general health between the two regions. Low prevalences of antibodies (neurona, and Leptospira interrogans. Exposure to phocine herpesvirus-1 was found in both Kodiak, USA (15.2%), and Bering Island, Russia (2.3%). Antibodies to Brucella spp. were found in 28% of the otters tested on Bering Island, Russia, compared with only 2.7% of the samples from Kodiak, USA. Prevalence of exposure to Phocine distemper virus (PDV) was 41% in Kodiak, USA, but 0% on Bering Island, Russia. Archived sera from southwest and south-central Alaska dating back to 1989 were negative for PDV, indicating exposure occurred in sea otters in Kodiak, USA, in recent years. Because PDV can be highly pathogenic in naïve and susceptible marine mammal populations, tissues should be examined to explore the contribution of this virus to otter deaths. Our results reveal an increase in exposure to pathogens in sea otters in Kodiak, Alaska, USA, since the 1990 s. PMID:21719822

  18. The role of PPARγ-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology.

    Science.gov (United States)

    Ramot, Yuval; Mastrofrancesco, Arianna; Camera, Emanuela; Desreumaux, Pierre; Paus, Ralf; Picardo, Mauro

    2015-04-01

    Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that modulate the expression of multiple different genes involved in the regulation of lipid, glucose and amino acid metabolism. PPARs and cognate ligands also regulate important cellular functions, including cell proliferation and differentiation, as well as inflammatory responses. This includes a role in mediating skin and pilosebaceous unit homoeostasis: PPARs appear to be essential for maintaining skin barrier permeability, inhibit keratinocyte cell growth, promote keratinocyte terminal differentiation and regulate skin inflammation. They also may have protective effects on human hair follicle (HFs) epithelial stem cells, while defects in PPARγ-mediated signalling may promote the death of these stem cells and thus facilitate the development of cicatricial alopecia (lichen planopilaris). Overall, however, selected PPARγ modulators appear to act as hair growth inhibitors that reduce the proliferation and promote apoptosis of hair matrix keratinocytes. The fact that commonly prescribed PPARγ-modulatory drugs of the thiazolidine-2,4-dione class can exhibit a battery of adverse cutaneous effects underscores the importance of distinguishing beneficial from clinically undesired cutaneous activities of PPARγ ligands and to better understand on the molecular level how PPARγ-regulated cutaneous lipid metabolism and PPARγ-mediated signalling impact on human skin physiology and pathology. Surely, the therapeutic potential that endogenous and exogenous PPARγ modulators may possess in selected skin diseases, ranging from chronic inflammatory hyperproliferative dermatoses like psoriasis and atopic dermatitis, via scarring alopecia and acne can only be harnessed if the complexities of PPARγ signalling in human skin and its appendages are systematically dissected. PMID:25644500

  19. Dual pathology of corticobasal degeneration and Parkinson′s disease in a patient with clinical features of progressive supranuclear palsy

    Directory of Open Access Journals (Sweden)

    Tomin Mooney

    2011-01-01

    Full Text Available Corticobasal degeneration and Parkinson′s disease are pathologically distinct disorders with unique histological and biochemical features of a tauopathy and a-synucleinopathy respectively. We report the first case of co-occurrence of these pathologies in the same patient. Convergence of such distinctly separate neuropathology in the same brain highlights the need for extensive brain banking and further research in supporting the hypothesis that tauopathies and a-synucleinopathies might share common pathogenic mechanisms.

  20. Dual pathology of corticobasal degeneration and Parkinson′s disease in a patient with clinical features of progressive supranuclear palsy

    OpenAIRE

    Tomin Mooney; Anthony Tampiyappa; Thomas Robertson; Rohan Grimley; Chris Burke; Kenneth Ng; Peter Patrikios

    2011-01-01

    Corticobasal degeneration and Parkinson′s disease are pathologically distinct disorders with unique histological and biochemical features of a tauopathy and a-synucleinopathy respectively. We report the first case of co-occurrence of these pathologies in the same patient. Convergence of such distinctly separate neuropathology in the same brain highlights the need for extensive brain banking and further research in supporting the hypothesis that tauopathies and a-synucleinopathies might share ...

  1. Clinical, pathological, and immunohistochemistry characterization of toxoplasmosis in dogs with distemper in the semiarid region of Paraíba, Brazil

    OpenAIRE

    Maria Talita Soares Frade; Lisanka Ângelo Maia; Rachel Livingstone Felizola Soares Andrade; Rodrigo Cruz Alves; Elise Miyuki Yamasaki; Rinaldo Aparecido Mota; Antônio Flávio Medeiros Dantas

    2015-01-01

    The objective of this study was to describe the clinical, pathological, and immunohistochemistry characteristics of five cases of toxoplasmosis, an infection often associated with distemper in dogs. From January 2000 to December 2012, a retrospective study was performed analyzed dogs with distemper in the semiarid region of Paraíba. We evaluated this sample to focus on individuals who presented with concomitant structures in protozoa characteristics, and performed immunohistochemistry (IHC) t...

  2. Integration of Clinical Data, Pathology, and cDNA Microarrays in Influenza Virus-Infected Pigtailed Macaques (Macaca nemestrina)†

    OpenAIRE

    Baskin, Carole R.; García-Sastre, Adolfo; Tumpey, Terrence M.; Bielefeldt-Ohmann, Helle; Carter, Victoria S.; Nistal-Villán, Estanislao; Katze, Michael G.

    2004-01-01

    For most severe viral pandemics such as influenza and AIDS, the exact contribution of individual viral genes to pathogenicity is still largely unknown. A necessary step toward that understanding is a systematic comparison of different influenza virus strains at the level of transcriptional regulation in the host as a whole and interpretation of these complex genetic changes in the context of multifactorial clinical outcomes and pathology. We conducted a study by infecting pigtailed macaques (...

  3. Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn)

    OpenAIRE

    Herbach, Nadja

    2002-01-01

    Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn) Gastrointestinal hormones like glucose-dependent insulinotropic polypeptide have recently been shown to be involved in the pathogenesis of diabetes mellitus in humans and animals models of diabetes mellitus. The aim of this study was to characterize a novel transgenic mouse model expressing...

  4. Pattern of Cutaneous Pathology among a Cohort of HIV/AIDS Patients Accessing Care in a Rural/Suburban Adult ART Clinic in Nigeria

    OpenAIRE

    Salami, T. A. T.; Adewuyi, G. M.; Echekwube, P.; Affusim, C.

    2013-01-01

    Background: Cutaneous diseases are common in patients with HIV/AIDS however there are few documented reports of these lesions from some parts of world such as Nigeria and West Africa. Objective: The aim of this study was to identify cutaneous pathologies in patients attending an adult outpatient (HIV/AIDS) clinic department in a rural/suburban centre in the south geopolitical zone of Nigeria. Additionally it also aims to determine if there are differences in the pattern of presentation as com...

  5. Expression of Yes-associated protein in non-small cell lung cancer and its relationship with clinical pathological factors

    Institute of Scientific and Technical Information of China (English)

    SU Li-li; MA Wei-xia; YUAN Jian-feng; SHAO Yang; XIAO Wei; JIANG Shu-juan

    2012-01-01

    Background Yes-associated protein(YAP)plays an important role in signal transduction and gene transcription regulation in normal cells,with elevated and over-expressed YAP levels observed in various malignant tumors.The aim of this study was to investigate the expression of YAP in non-small cell lung cancer(NSCLC),and to study the possible relationship of YAP expression with the occurrence and development of NSCLC.Methods YAP expression was assessed in 40 cases of NSCLC tumor tissues by immunohistochemistry,and their protein and mRNA levels were evaluated through Western blotting and reverse transcription-polymerase chain reaction(PCR),respectively.Normal lung tissues obtained from the same patient were used as control.Statistical analysis was performed to correlate the YAP expression to clinical pathological factors,such as tumor type,stage and grade.Results YAP-positive expression was found in 28(70%)of the 40 cases of NSCLC,which included 10 cases of squamous cell carcinoma(25%),17 cases of adenocarcinoma(42.5%)and 1 case of squamous adenocarcinoma(2.5%).In the 28 YAP-positive cases,19 cases showed lymph node metastasis and were classified in TNM stage Ⅱ+Ⅲ(47.5%);the other nine cases showed no lymph node metastasis(22.5%)and were classified in the TNM stage Ⅰ.There was no relationship between YAP expression and patients'age,gender or tumor histological grades.However,YAP showed significant over expression in late period of T stage(P=0.012),TNM stage(P=0.039),and lymph node metastasis(P=0.013),respectively.Notably,YAP-positive expression was significantly higher in adenocarcinoma than that in squamous cell carcinoma(P=0.041).Conclusions Over-expression of YAP was associated with NSCLC,especially lung adenocarcinoma.The high YAP expression in late period of tumor stage and lymph node metastasis may indicate that YAP expression could be an early marker for NSCLC tumorigenesis.

  6. Clinical predictors of severe cerebral amyloid angiopathy and influence of APOE genotype in persons with pathologically-verified Alzheimer’s disease

    Science.gov (United States)

    Ringman, John M.; Sachs, Michael C.; Zhou, Yan; Monsell, Sarah E.; Saver, Jeffrey L.; Vinters, Harry V.

    2014-01-01

    Importance Though cerebral amyloid angiopathy (CAA) has important clinical implications, our understanding of it and ability to diagnose it is limited. Objective We sought to determine pathological correlates and clinical factors identifiable during life that predict the presence of severe CAA in persons with pathologically-confirmed Alzheimer’s disease (AD). Design We compared demographic and clinical variables at the earliest visit during life at which subjects were found to have cognitive impairment, and pathological variables between persons ultimately found to have no or severe CAA at autopsy using logistic regression. Analyses were repeated separately for carriers and non-carriers of the APOE ε4 allele. Setting Data were obtained from the Uniform Data Set that comprises longitudinal clinical assessments performed in the Alzheimer’s Disease Centers funded by the National Institute on Aging. Participants 193 persons with severe CAA and 232 persons with no CAA. All subjects had cognitive impairment and met NIA-Reagan neuropathological criteria for AD. Main Outcome Measures Prevalence of demographic characteristics and the APOE ε4 allele and odds ratios of clinical variables for the prediction of severe CAA. Results Persons with severe CAA were more likely to carry an APOE ε4 allele (64.9% vs. 42.8%), to be Hispanic (6.8% vs. 1.3%, p = 0.003), to have had a transient ischemic attack (TIA, 12.5% vs. 6.1%, OR = 2.1, 95% CI = 1 – 4.4), and had lower degrees of diffuse amyloid plaque pathology (mean CERAD scores 1.2 vs. 1.4, p = 0.01) than persons with no CAA. Intracerebral hemorrhage (9.3% vs. 3.5%, p = 0.01), cortical microinfarcts (20.7% vs. 12.9%, p = 0.03), and subcortical leukoencephalopathy (20.5% vs. 12.1%, p = 0.02) were more common in persons with CAA. A higher prevalence of stroke (11.1% vs. 3.9%, OR = 3.8, 95% CI 1.0 – 14.6) and hypercholesterolemia (50% vs. 33.3%, OR = 2.3, CI 1.1 – 4.7) were found in non-carriers of the ε4 allele with

  7. Dynamic contrast-enhanced MRI texture analysis for pretreatment prediction of clinical and pathological response to neoadjuvant chemotherapy in patients with locally advanced breast cancer.

    Science.gov (United States)

    Teruel, Jose R; Heldahl, Mariann G; Goa, Pål E; Pickles, Martin; Lundgren, Steinar; Bathen, Tone F; Gibbs, Peter

    2014-08-01

    The aim of this study was to investigate the potential of texture analysis, applied to dynamic contrast-enhanced MRI (DCE-MRI), to predict the clinical and pathological response to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC) before NAC is started. Fifty-eight patients with LABC were classified on the basis of their clinical response according to the Response Evaluation Criteria in Solid Tumors (RECIST) guidelines after four cycles of NAC, and according to their pathological response after surgery. T1 -weighted DCE-MRI with a temporal resolution of 1 min was acquired on a 3-T Siemens Trio scanner using a dedicated four-channel breast coil before the onset of treatment. Each lesion was segmented semi-automatically using the 2-min post-contrast subtracted image. Sixteen texture features were obtained at each non-subtracted post-contrast time point using a gray level co-occurrence matrix. Appropriate statistical analyses were performed and false discovery rate-based q values were reported to correct for multiple comparisons. Statistically significant results were found at 1-3 min post-contrast for various texture features for the prediction of both the clinical and pathological response. In particular, eight texture features were found to be statistically significant at 2 min post-contrast, the most significant feature yielding an area under the curve (AUC) of 0.77 for response prediction for stable disease versus complete responders after four cycles of NAC. In addition, four texture features were found to be significant at the same time point, with an AUC of 0.69 for response prediction using the most significant feature for classification based on the pathological response. Our results suggest that texture analysis could provide clinicians with additional information to increase the accuracy of prediction of an individual response before NAC is started. PMID:24840393

  8. A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration.

    Science.gov (United States)

    Nakamura, Masataka; Bieniek, Kevin F; Lin, Wen-Lang; Graff-Radford, Neill R; Murray, Melissa E; Castanedes-Casey, Monica; Desaro, Pamela; Baker, Matthew C; Rutherford, Nicola J; Robertson, Janice; Rademakers, Rosa; Dickson, Dennis W; Boylan, Kevin B

    2015-07-01

    Amyotrophic lateral sclerosis (ALS) is a degenerative disorder affecting upper and lower motor neurons, but it is increasingly recognized to affect other systems, with cognitive impairment resembling frontotemporal dementia (FTD) in some patients. We report clinical and pathologic findings of a family with ALS due to a truncating mutation, p.Gly141X, in copper/zinc superoxide dismutase (SOD1). The proband presented clinically with FTD and later showed progressive motor neuron disease, while all other family members had early-onset and rapidly progressive ALS without significant cognitive deficits. Pathologic examination of both the proband and her daughter revealed degeneration of corticospinal tracts and motor neurons in brain and spinal cord compatible with ALS. On the other hand, the proband also had neocortical and limbic system degeneration with pleomorphic neuronal cytoplasmic inclusions. Extramotor pathology in her daughter was relatively restricted to the hypothalamus and extrapyramidal system, but not the neocortex. The inclusions in the proband and her daughter were immunoreactive for SOD1, but negative for TAR DNA-binding protein of 43 kDa (TDP-43). In the proband, a number of the neocortical inclusions were immunopositive for α-internexin, initially suggesting a diagnosis of atypical FTLD, but there was no evidence of fused in sarcoma (FUS) immunoreactivity, which is often detected in atypical FTLD. Analogous to atypical FTLD, neuronal inclusions had variable co-localization of SOD1 and α-internexin. The current classification of FTLD is based on the major constituent protein: FTLD-tau, FTLD-TDP-43, and FTLD-FUS. The proband in this family indicates that SOD1, while rare, can also be the substrate of FTLD, in addition to the more common presentation of ALS. The explanation for clinical and pathologic heterogeneity of SOD1 mutations, including the p.Gly141X mutation, remains unresolved. PMID:25917047

  9. Long-term follow-up of post hematopoietic stem cell transplantation for Hurler syndrome: Clinical, biochemical, and pathological improvements

    Directory of Open Access Journals (Sweden)

    Eriko Yasuda

    2015-03-01

    In conclusion, this long-term post-HSCT observation should shed light on a new aspect of therapeutic effect associated with skeletal pathology and GAG levels as a biomarker, indicating that HSCT is a primary choice at an early stage for not only CNS but also skeletal system in combination of appropriate surgical procedures.

  10. 单纯多发性肌炎141例临床和病理研究%The Study of Clinic and Pathology on 141 Patients with Simple Polymyositis

    Institute of Scientific and Technical Information of China (English)

    宁景春; 杨晓苏; 肖波

    2002-01-01

    Objective To study the clinical feature, pathological manifestation of Simple Polymyositis. Methods Theclinical situation, serum emzymes, electromyography (EMG) and muscular pathology of 141 patients with SPM wereinvestigated. Results Muscle weakless, myalgia, elevation of creatine kinase and abnormal EMG of myogenic damage werevery frequently to see in SPM. The muscle biopsy showed degeneration, necrosis and regeneration of muscle fibres, sporadicmuscle fibre atrophy and endomysial inflammatory infiltrate. Conclusion Muscular pathology is very important methods todiagnosis or study the pathogenesis in SPM.

  11. PBL教学法和CPC教学法在病理学实验课中的应用%Application of Problem-based Learning and Clinical Pathology Conference in Pathology Classroom Practice

    Institute of Scientific and Technical Information of China (English)

    李娟; 胡晓松; 刘馨莲; 孙静; 李淑蓉

    2007-01-01

    病理学是一门联系基础医学和临床医学的桥梁课程,实验课是病理学教学中的重要环节,传统教学法不能充分调动学生学习的积极性,已难适应本科教学的要求.为此,作者在教学中开始尝试以问题为基础的学习法(problem-based learning,PBL)和临床病理讨论(clinical pathology conference,CPC),提高教学效果,培养学生的创造性和积极思考能力.

  12. 病理性联带运动的临床和实验研究%Clinical and experimental studies of pathological synkinesia

    Institute of Scientific and Technical Information of China (English)

    任重; 马秀岚; 石阳

    2001-01-01

    Objective The clinical manifestations and mechanism of pathological synkinesia were studied. Methods Recurrent pathological synkinesia was measured by clinical and experimental nictitation reflex. The changes of nerve-muscle junctions were observed via scanning electron microscope. Results All the 32 cases of pathological synkinesia were denervation of degree Ⅲ and severe facial palsy. Reaction undulatory forms of musculus orbicularis oculi and musculus orbicularis oris recorded simultaneously at the stimulated side in trigemial-facial nerve reflex test accounted for 81%(28/32) patients and 89% guinea pigs. Conclusion Pathological synkinesia was the marker of severe facial palsy and was related with over-error in regeneration of nerve.%目的 探讨病理性联带运动的临床表现和产生机制。方法 通过瞬目反射临床和实验测试重现病理性联带运动,应用扫描电镜观察神经纤维和肌纤维的神经—肌结合部的变化。结果 32例病理性联带运动全部为失神经支配Ⅲ度和重度面神经麻痹。81%(28/32)病例和89%豚鼠瞬目反射测试在刺激侧同时记录到眼轮匝肌和口轮匝肌反应波形。结论 病理性联带运动是重度面神经麻痹的标志,与神经再生过误有关。

  13. Adult multilocular cystic nephroma: Report of six cases with clinical, radio-pathologic correlation and review of literature

    Directory of Open Access Journals (Sweden)

    Christopher Wilkinson

    2013-01-01

    Conclusions: MCN is a benign cystic lesion and clinical presentations are nonspecific with symptoms such as abdominal pain, hematuria and urinary tract infection. These nonspecific clinical presentations and confusing radiological features create difficult preoperative differentiation from malignant cystic renal neoplasms.

  14. Pathological Internet use and psychiatric disorders: A cross-sectional study on psychiatric phenomenology and clinical relevance of Internet dependency

    OpenAIRE

    Bert Theodor te Wildt; Inken Putzig; Marion Drews; Stefanie Lampen-Imkamp; Markus Zedler; Birgitt Wiese; Wolfgang Dillo; Martin Detlef Ohlmeier

    2010-01-01

    Background and Objectives: With the Cyberspace´s exponential growth of influence questions arise about its mental impacts. The presented study examines the question whether the dependent use of the Internet can be understood as an impulse control disorder, an addiction or as a symptom of other psychiatric conditions. Methods: Internet dependent patients seeking for psychiatric assistance and fulfilling the criteria for pathological Internet use (PIU) were examined with the Structured Cl...

  15. An Exploratory Study of Clinical Measures Associated with Subsyndromal Pathological Gambling in Patients with Binge Eating Disorder

    OpenAIRE

    Yip, Sarah W.; White, Marney A.; Grilo, Carlos M.; Potenza, Marc N.

    2011-01-01

    Both binge eating disorder (BED) and pathological gambling (PG) are characterized by impairments in impulse control. Subsyndromal levels of PG have been associated with measures of adverse health. The nature and significance of PG features in individuals with BED is unknown. Ninety-four patients with BED (28 men and 66 women) were classified by gambling group based on inclusionary criteria for Diagnostic and Statistical Manual-IV (DSM-IV) PG and compared on a range of behavioral, psychologica...

  16. Receiver-operating characteristic curves and likelihood ratios: improvements over traditional methods for the evaluation and application of veterinary clinical pathology tests

    DEFF Research Database (Denmark)

    Gardner, Ian A.; Greiner, Matthias

    2006-01-01

    Receiver-operating characteristic (ROC) curves provide a cutoff-independent method for the evaluation of continuous or ordinal tests used in clinical pathology laboratories. The area under the curve is a useful overall measure of test accuracy and can be used to compare different tests (or differ...... calculated as the slope (tangent) to the ROC curve at a unique test value. We use ROC analysis and calculate likelihood ratios to evaluate the performance of tests reported in 2 articles previously published in this journal....... specificity in test evaluation studies. In addition, calculation of likelihood ratios can potentially improve the clinical utility of such studies because likelihood ratios provide an indication of how the post-test probability changes as a function of the magnitude of the test results. For ordinal test......Receiver-operating characteristic (ROC) curves provide a cutoff-independent method for the evaluation of continuous or ordinal tests used in clinical pathology laboratories. The area under the curve is a useful overall measure of test accuracy and can be used to compare different tests (or...

  17. The role of biofluid mechanics in the assessment of clinical and pathological observations: sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008 Pasadena, California

    NARCIS (Netherlands)

    M. Siebes; Y. Ventikos

    2010-01-01

    Biofluid mechanics is increasingly applied in support of diagnosis and decision-making for treatment of clinical pathologies. Exploring the relationship between blood flow phenomena and pathophysiological observations is enhanced by continuing advances in the imaging modalities, measurement techniqu

  18. 系统性红斑狼疮的临床病理研究%Clinical pathological research of systemic lupus erythematosus

    Institute of Scientific and Technical Information of China (English)

    高涵; 曲世平

    2016-01-01

    目的:研究系统性红斑狼疮的临床表现及病理变化。方法选取58例系统性红斑狼疮患者,记录并研究所有患者的临床病理情况。结果患有系统性红斑狼疮的58例患者中,10例出现了狼疮性肾炎,8例患者心脏受累,2例患者累及神经系统,9例患者皮肤感染,3例患者引发肺部疾病。另外,多达17例患者出现血液成分异常。结论系统性红斑狼疮的临床表现及病理变化较为复杂,对人体的心脏、肾脏及皮肤等重要器官损害巨大。%ObjectiveTo research clinical manifestations and pathological changes of systemic lupus erythematosus.MethodsA total of 58 patients with systemic lupus erythematosus were selected, and their clinical pathology condition were recorded for research.ResultsAmong the 58 patients with systemic lupus erythematosus, there were 10 cases with lupus nephritis, 8 cases with involved heart, 2 cases with involved nervous system, 9 cases with skin infection, and 3 cases with lung disease. There were also 17 cases with abnormal blood composition.ConclusionSystemic lupus erythematosus shows complex clinical manifestations and pathological changes, and it has severe damage on important organs, such as heart, kidney and skin.

  19. Clinical Pathologic Study on Effect of Qianggan Capsule (强肝胶囊)in Treating Patients of Chronic Hepatitis B With Liver Cirrhosis

    Institute of Scientific and Technical Information of China (English)

    杨柳明; 赵延龙; 吴志荣; 陈杜芳; 岑卓英; 徐克成; 左建生; 危北海; 张万岱

    2002-01-01

    Objective: To explore the clinical therapeutic effect of Qianggan Capsule (QGC) in treating chronic hepatitis B with liver fibrosis from the pathological aspect. Methods: Sixty-three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group (n=45) and the control group (n=18). Both groups were treated with general liver protective drugs, such as Glucurone and vitamins B complex for 6 months. To the treated group, QGC was used additionally. The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid (HA), collagen type Ⅳ (C-Ⅳ) and laminin (LN) as well as the pathological examination of liver biopsy were observed before and after treatment. Results: The liver cirrhosis indexes, HA, C-Ⅳ and LN, were improved significantly in the treated group after treatment, P0.05. Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57.8% and that on liver fibrosis stage was 75.6%, which were significantly improved as compared with those before treatment (P0.05). Conclusion: QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis, and could lower the serum liver fibrosis related indexes effectively.

  20. Diagnóstico clínico e anatomopatológico: discordâncias Clinical diagnosis and anatomic-pathologic diagnosis: disagreements

    Directory of Open Access Journals (Sweden)

    José Roberto Alves

    2004-04-01

    Full Text Available Muitas patologias na prática clínica geram discordâncias quanto a sua identificação, não somente pela sua semelhança com outras lesões mas também pela sua semântica. OBJETIVO: Este trabalho visa esclarecer quais discordâncias são mais freqüentes na prática clínica, fornecer novos conhecimentos para facilitar a identificação das patologias de maiores controvérsias e ampliar seus diagnósticos diferenciais. MÉTODOS: Revisamos 1.825 laudos de biópsias referentes ao período de 1992 até 1999, pertencentes ao Laboratório de Anatomia Patológica da Unoeste, sendo excluídos 439 laudos que não apresentavam hipótese diagnóstica ou que tinham como hipótese sinais e sintomas clínicos ou "a esclarecer". Confrontamos a hipótese clínica com o diagnóstico anatomopatológico, obtendo-se 444 (32,05% casos discordantes. RESULTADOS: Observamos que as maiores discordâncias foram entre o diagnóstico clínico de hanseníase, que em 65,7% dos casos tratavam-se de dermatites crônicas inespecíficas, entre cisto sebáceo, que em 80% dos casos tratavam-se de cisto de inclusão epidérmica e aborto incompleto, que em 68,2% dos casos tratavam-se de aborto completo. CONCLUSÃO: Concluímos que uma adequada definição de conceitos, uma anamnese criteriosa e estreita correlação das características clínicas das lesões promovem um menor número de discordâncias entre os diagnósticos clínico e anatomopatológico.Many pathologic entities in the clinical practice generate disagreements regarding its identification, not only by its likeness with other lesions but also by its semantics. BACKGROUND: The goal of this work is to clarify which disagreements are more frequent in the clinical practice, supply new knowledges to facilitate the identification of the larger pathologies controversies and to enlarge its differentials diagnosis. METHODS: We revised 1825 reports of referring biopsies to the period of 1992 up to 1999, belonging to the

  1. Spectrum of Ultrasound Pathologies of Achilles Tendon, Plantar Aponeurosis and Flexor Digiti Brevis Tendon Heel Entheses in Patients with Clinically Suspected Enthesitis

    International Nuclear Information System (INIS)

    Enthesitis is considered a characteristic presentation of the second most common group of rheumatoid disorders, i.e. spondyloarthropathies (SpAs), particularly peripheral spondyloarthropathies. At the initial stages, enthesitis may be the only symptom of SpA, particularly in patients lacking the HLA-B27 receptor. In light of diagnostic difficulties with detecting enthesitis in clinical examinations and laboratory investigations, many studies point out the high specificity of imaging studies, and particularly ultrasonography. A total of 20% Achilles tendon entheses, 45% plantar aponeurosis entheses and 89.5% of flexor digiti brevis tendon entheses were unremarkable. In the remaining cases, the presentation of pathological lesions was not specific to enthesitis and might more likely correspond to degeneration or microinjuries of the entheses, beside the most obvious cases of achillobursitis or Kager’s fat pad inflammation. The studies demonstrated that ultrasound scans rarely confirm the clinical diagnosis of enthesitis

  2. Does posterior cingulate hypometabolism result from disconnection or local pathology across preclinical and clinical stages of Alzheimer's disease?

    International Nuclear Information System (INIS)

    Posterior cingulate cortex (PCC) hypometabolism as measured by FDG PET is an indicator of Alzheimer's disease (AD) in prodromal stages, such as in mild cognitive impairment (MCI), and has been found to be closely associated with hippocampus atrophy in AD dementia.We studied the effects of local and remote atrophy and of local amyloid load on the PCC metabolic signal in patients with different preclinical and clinical stages of AD. We determined the volume of the hippocampus and PCC grey matter based on volumetric MRI scans, PCC amyloid load based on AV45 PET, and PCC metabolism based on FDG PET in 667 subjects participating in the Alzheimer's Disease Neuroimaging Initiative spanning the range from cognitively normal ageing through prodromal AD to AD dementia. In cognitively normal individuals and those with early MCI, PCC hypometabolism was exclusively associated with hippocampus atrophy, whereas in subjects with late MCI it was associated with both local and remote effects of atrophy as well as local amyloid load. In subjects with AD dementia, PCC hypometabolism was exclusively related to local atrophy. Our findings suggest that the effects of remote pathology on PCC hypometabolism decrease and the effects of local pathology increase from preclinical to clinical stages of AD, consistent with a progressive disconnection of the PCC from downstream cortical and subcortical brain regions. (orig.)

  3. Significant differe nces in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients

    Directory of Open Access Journals (Sweden)

    Raquel Ajub Moyses

    2013-06-01

    Full Text Available OBJECTIVE: As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smoking and alcohol consumption habits of patients in a Brazilian cohort. METHODS: We prospectively analyzed the smoking and alcohol consumption habits of 1,633 patients enrolled in five São Paulo hospitals that participated in the Brazilian Head and Neck Genome Project - Gencapo. RESULTS: The patients who smoked and drank were younger, and those who smoked were leaner than the other patients, regardless of alcohol consumption. The non-smokers/non-drinkers were typically elderly white females who had more differentiated oral cavity cancers and fewer first-degree relatives who smoked. The patients who drank presented significantly more frequent nodal metastasis, and those who smoked presented less-differentiated tumors. CONCLUSIONS: The patients with squamous cell carcinoma of the head and neck demonstrated demographic, clinical, and pathological features that were markedly different according to their smoking and drinking habits. A subset of elderly females who had oral cavity cancer and had never smoked or consumed alcohol was notable. Alcohol consumption seemed to be related to nodal metastasis, whereas smoking correlated with the degree of differentiation.

  4. Does posterior cingulate hypometabolism result from disconnection or local pathology across preclinical and clinical stages of Alzheimer's disease?

    Energy Technology Data Exchange (ETDEWEB)

    Teipel, Stefan [University of Rostock, Department of Psychosomatic Medicine, Rostock (Germany); DZNE, German Center for Neurodegenerative Diseases, Rostock (Germany); Alzheimer' s Disease Neuroimaging Initiative (United States); Grothe, Michel J. [DZNE, German Center for Neurodegenerative Diseases, Rostock (Germany); Alzheimer' s Disease Neuroimaging Initiative (United States)

    2016-03-15

    Posterior cingulate cortex (PCC) hypometabolism as measured by FDG PET is an indicator of Alzheimer's disease (AD) in prodromal stages, such as in mild cognitive impairment (MCI), and has been found to be closely associated with hippocampus atrophy in AD dementia.We studied the effects of local and remote atrophy and of local amyloid load on the PCC metabolic signal in patients with different preclinical and clinical stages of AD. We determined the volume of the hippocampus and PCC grey matter based on volumetric MRI scans, PCC amyloid load based on AV45 PET, and PCC metabolism based on FDG PET in 667 subjects participating in the Alzheimer's Disease Neuroimaging Initiative spanning the range from cognitively normal ageing through prodromal AD to AD dementia. In cognitively normal individuals and those with early MCI, PCC hypometabolism was exclusively associated with hippocampus atrophy, whereas in subjects with late MCI it was associated with both local and remote effects of atrophy as well as local amyloid load. In subjects with AD dementia, PCC hypometabolism was exclusively related to local atrophy. Our findings suggest that the effects of remote pathology on PCC hypometabolism decrease and the effects of local pathology increase from preclinical to clinical stages of AD, consistent with a progressive disconnection of the PCC from downstream cortical and subcortical brain regions. (orig.)

  5. Clinical profiles as a function of level and type of impulsivity in a sample group of at-risk and pathological gamblers seeking treatment.

    Science.gov (United States)

    Grall-Bronnec, Marie; Wainstein, Laura; Feuillet, Fanny; Bouju, Gaëlle; Rocher, Bruno; Vénisse, Jean-Luc; Sébille-Rivain, Véronique

    2012-06-01

    Level and type of impulsivity are essential variables to be taken into consideration during the initial evaluation of a pathological gambler. The aim of this study was to measure the score for 4 impulsivity-related traits (Urgency, (lack of) Premeditation, (lack of) Perseverance and Sensation seeking) in a sample group of at-risk and pathological gamblers, and to highlight any links with certain elements of clinical data. The UPPS Impulsive Behaviour Scale was administered to 84 problem gamblers seeking treatment. The severity of gambling disorders was evaluated using the diagnostic criteria of the DSM-IV. Psychiatric and addictive comorbidities were also explored. The results indicated that the score for the Urgency facet had a positive correlation with the severity of gambling disorders. It appeared that participants displayed different clinical profiles according to the level and type of impulsivity. Several of the UPPS scales were identified as risk factors for mood disorders, risk of suicide, alcohol use disorders, and Attention Deficit/Hyperactivity Disorder (ADHD). The results confirm both the complexity of the multi-dimensional concept of impulsivity and the reason why the UPPS is of interest for a more in-depth study of the subject. PMID:21698341

  6. Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease

    Institute of Scientific and Technical Information of China (English)

    李深; 饶向荣; 王素霞; 张改华; 李晓玫; 戴希文; 陈可冀

    2009-01-01

    To investigate the relationship between the severity of Chinese medicine(CM) bloodstasis syndrome(BSS) with clinical features and renal lesion indexes of the primary glomerular disease. Methods:An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases,and their severity of BSS were scored three days before renal biopsies were performed.The following clinical indexes were analyzed:age,course of glomerular diseases,24-h urine protein ration...

  7. Mass stranding of striped dolphin, Stenella coeruleoalba, at Augusta, Western Australia: notes on clinical pathology and general observations.

    Science.gov (United States)

    Gales, N J

    1992-10-01

    Seventeen striped dolphins, Stenella coeruleoalba, were found stranded on a West Australian beach. Three animals died before a rescue attempt was made and a further three died during the rescue. The remaining dolphins were released 24 km offshore and were not seen again. One dolphin was noted to have a broken mandible. Evidence of physical trauma to the other dolphins was minimal; one adult female was observed with some peeling skin. Blood was collected for analysis. All dolphins were slightly dehydrated and had a leukogram typical of a stressed animal. Plasma biochemistry reflected primary muscle trauma. There were no clues to the cause of the stranding; observed pathology reflected damage that occurred as a direct consequence of stranding. PMID:1474667

  8. Bilateral synchronous granulomatous orchitis in a patient with erectile disfunction: clinical and pathologic study of the case.

    Science.gov (United States)

    Rodriguez Peña, M; Moreno, D

    2013-01-01

    A 50-year-old male patient presented with erectile failure and loss of libido. In the physical examination, there were stone-hard indurations in his bilateral testes. The ultrasonographic study demonstrated multiple hypoechoic areas in the testes and normal epididymis. Since the lesion was presumed as malignancy, bilateral inguinal exploration was performed and intraoperative frozen biopsies were studied and diagnosed as inflammatory process. Nevertheless, we decided to perform left orchiectomy to a deeper histopathologic analysis which revealed granulomatous orchitis, mastocytosis, and severe depletion of Leydig cells at the testicular interstitium. Differential diagnosis between testicular tumor and granulomatous orchitis is very difficult in any examination except by histological findings. Bilateral cases of this pathology are relatively rare, but it is necessary to distinguish them from the testicular tumor before surgical intervention to avoid an unnecessary orchiectomy. PMID:24288647

  9. The clinical spectrum of renal osteodystrophy in 57 chronic hemodialysis patients: a correlation between biochemical parameters and bone pathology findings.

    Science.gov (United States)

    Chazan, J A; Libbey, N P; London, M R; Pono, L; Abuelo, J G

    1991-02-01

    Fifty-nine chronic hemodialysis patients who had been on dialysis for an average of 77 months underwent bone biopsies and the pathologic findings were correlated with biochemical and demographic data. All but two had evidence of renal osteodystrophy, 23 with osteitis fibrosa (OF), 19 with osteomalacia and/or adynamic disease (OM/AD), and 15 with mixed osteodystrophy (MOD). Patients in each group were similar with regard to age, sex distribution, duration of dialysis, unstimulated serum aluminum, calcium and phosphorus. Patients with osteitis fibrosa (OF) had statistically higher DFO stimulated aluminum, alkaline phosphatase and PTHC levels than the other two groups although there was marked individual variation. The bone biopsies were also evaluated for the amount of aluminum deposited in the osteoid seam. All 23 of the patients with OF and 11 of the 15 patients with MOD had no, mild, or minimal aluminum deposition but 12 of the 19 patients with OM/AD had moderate to marked aluminum deposition. Patients with minimal to mild aluminum deposition were similar in age, duration of dialysis, sex distribution, unstimulated and DFO stimulated aluminum levels, calcium, phosphorus, alkaline phosphatase to those with moderate to marked deposition but had significantly higher parathormone levels. All patients had been treated in a similar fashion regarding diet, oral phosphate binders and vitamin D; therefore, the observed differences in bone pathology were not readily explicable. However, patients who were found to have osteitis fibrosa and those with minimal to mild aluminum deposition had significantly higher parathormone levels when compared with patients in the other groups at the inception of dialysis. PMID:2019018

  10. Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Alan W., E-mail: alan_katz@urmc.rochester.edu [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States); Chawla, Sheema [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States); Qu, Zhenhong [Anatomic Pathology, William Beaumont Hospital, Royal Oak, Michigan (United States); Kashyap, Randeep [Department of Solid Organ Transplant, University of Rochester Medical Center, Rochester, New York (United States); Milano, Michael T. [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States); Hezel, Aram F. [Department of Medicine, Division of Hematology and Oncology, University of Rochester Medical Center, Rochester, New York (United States)

    2012-07-01

    Purpose: We sought to determine efficacy, safety, and outcome of stereotactic hypofractionated radiation therapy (SHORT) as a suitable bridging therapy for patients awaiting liver transplantation (LT) for hepatocellular carcinoma (HCC). We also examined histological response to radiation in the resected or explanted livers. Methods and Materials: Between August 2007 and January 2009, 18 patients with 21 lesions received SHORT. A median total dose of 50 Gy was delivered in 10 fractions. Three patients underwent either chemoembolization (n = 1) or radiofrequency ablation (n = 2) prior to SHORT. Radiographic response was based on computed tomography evaluation at 3 months after SHORT. Histological response as a percentage of tumor necrosis was assessed by a quantitative morphometric method. Results: Six of 18 patients were delisted because of progression (n = 3) or other causes (n = 3). Twelve patients successfully underwent major hepatic resection (n = 1) or LT (n = 11) at a median follow-up of 6.3 months (range, 0.6-11.6 months) after completion of SHORT. No patient developed gastrointestinal toxicity Grade {>=}3 or radiation-induced liver disease. Ten patients with 11 lesions were evaluable for pathological response. Two lesions had 100% necrosis, three lesions had {>=}50% necrosis, four lesions had {<=}50% necrosis, and two lesions had no necrosis. All patients were alive after LT and/or major hepatic resection at a median follow-up of 19.6 months. Conclusions: SHORT is an effective bridging therapy for patients awaiting LT for HCC. It provides excellent in-field control with minimal side effects, helps to downsize or stabilize tumors prior to LT, and achieves good pathological response.

  11. Pathology Gross Photography: The Beginning of Digital Pathology.

    Science.gov (United States)

    Rampy, B Alan; Glassy, Eric F

    2016-03-01

    The underutilized practice of photographing anatomic pathology specimens from surgical pathology and autopsies is an invaluable benefit to patients, clinicians, pathologists, and students. Photographic documentation of clinical specimens is essential for the effective practice of pathology. When considering what specimens to photograph, all grossly evident pathology, absent yet expected pathologic features, and gross-only specimens should be thoroughly documented. Specimen preparation prior to photography includes proper lighting and background, wiping surfaces of blood, removing material such as tubes or bandages, orienting the specimen in a logical fashion, framing the specimen to fill the screen, positioning of probes, and using the right-sized scale. PMID:26851666

  12. Comprehensive small animal imaging strategies on a clinical 3 T dedicated head MR-scanner; adapted methods and sequence protocols in CNS pathologies.

    Directory of Open Access Journals (Sweden)

    Deepu R Pillai

    Full Text Available BACKGROUND: Small animal models of human diseases are an indispensable aspect of pre-clinical research. Being dynamic, most pathologies demand extensive longitudinal monitoring to understand disease mechanisms, drug efficacy and side effects. These considerations often demand the concomitant development of monitoring systems with sufficient temporal and spatial resolution. METHODOLOGY AND RESULTS: This study attempts to configure and optimize a clinical 3 Tesla magnetic resonance scanner to facilitate imaging of small animal central nervous system pathologies. The hardware of the scanner was complemented by a custom-built, 4-channel phased array coil system. Extensive modification of standard sequence protocols was carried out based on tissue relaxometric calculations. Proton density differences between the gray and white matter of the rodent spinal cord along with transverse relaxation due to magnetic susceptibility differences at the cortex and striatum of both rats and mice demonstrated statistically significant differences. The employed parallel imaging reconstruction algorithms had distinct properties dependent on the sequence type and in the presence of the contrast agent. The attempt to morphologically phenotype a normal healthy rat brain in multiple planes delineated a number of anatomical regions, and all the clinically relevant sequels following acute cerebral ischemia could be adequately characterized. Changes in blood-brain-barrier permeability following ischemia-reperfusion were also apparent at a later time. Typical characteristics of intra-cerebral haemorrhage at acute and chronic stages were also visualized up to one month. Two models of rodent spinal cord injury were adequately characterized and closely mimicked the results of histological studies. In the employed rodent animal handling system a mouse model of glioblastoma was also studied with unequivocal results. CONCLUSIONS: The implemented customizations including extensive

  13. Clinical pathology reference intervals for an in-water population of juvenile loggerhead sea turtles (Caretta caretta in Core Sound, North Carolina, USA.

    Directory of Open Access Journals (Sweden)

    Terra R Kelly

    Full Text Available The loggerhead sea turtle (Caretta caretta is found throughout the waters of the Atlantic, Pacific, and Indian Oceans. It is a protected species throughout much of its range due to threats such as habitat loss, fisheries interactions, hatchling predation, and marine debris. Loggerheads that occur in the southeastern U.S. are listed as "threatened" on the U.S. Endangered Species List, and receive state and federal protection. As part of an on-going population assessment conducted by the National Marine Fisheries Service, samples were collected from juvenile loggerhead sea turtles in Core Sound, North Carolina, between 2004 and 2007 to gain insight on the baseline health of the threatened Northwest Atlantic Ocean population. The aims of the current study were to establish hematologic and biochemical reference intervals for this population, and to assess variation of the hematologic and plasma biochemical analytes by season, water temperature, and sex and size of the turtles. Reference intervals for the clinical pathology parameters were estimated following Clinical Laboratory Standards Institute guidelines. Season, water temperature, sex, and size of the turtles were found to be significant factors of variation for parameter values. Seasonal variation could be attributed to physiological effects of decreasing photoperiod, cooler water temperature, and migration during the fall months. Packed cell volume, total protein, and albumin increased with increasing size of the turtles. The size-related differences in analytes documented in the present study are consistent with other reports of variation in clinical pathology parameters by size and age in sea turtles. As a component of a health assessment of juvenile loggerhead sea turtles in North Carolina, this study will serve as a baseline aiding in evaluation of trends for this population and as a diagnostic tool for assessing the health and prognosis for loggerhead sea turtles undergoing

  14. Experimental induced avian E. coli salpingitis: Significant impact of strain and host factors on the clinical and pathological outcome.

    Science.gov (United States)

    Olsen, Rikke Heidemann; Thøfner, Ida Cecilie Naundrup; Pors, Susanne Elisabeth; Pires Dos Santos, Teresa; Christensen, Jens Peter

    2016-05-30

    Several types of Escherichia coli have been associated with extra-intestinal infections in poultry, however, they may vary significantly in their virulence potential. The aim of the present study was to investigate the virulence of five strains of E. coli obtained from different disease manifestations or from the cloacae of a healthy chicken. The virulence potential of the strains were evaluated in an avian experimental model for ascending infections, and experiments were conducted in both layers and broiler breeders. The clinical outcome of infection was highly depending on the challenge strain, however, not significantly reflecting the origin of the strain. In general, broiler breeders had a more severe clinical outcomes of infection compared to layers, but major with-in group diversity was observed for all challenge strains of clinical origin. A single strain of ST95 (phylogroup B2) had a distinct ability to cause disease. Results of the study shows major differences in virulence of different strains of E. coli in ascending infections; however, there was no indication of tissue-specific adaptation, since strains obtained from lesions unrelated to the reproductive system were fully capable of causing experimental infection. In conclusion, the study provides evidence for the clinical outcome of infection with E. coli in poultry is largely influenced by the specific strain as well as individual host factors. PMID:27139030

  15. IMMUNO-BIOCHEMICAL AND CLINICAL RESEARCHES ON THE EVOLUTION OF ANTIOXIDANTS’ LEVEL IN THE ETIOPATHOGENY OF PERIODONTAL PATHOLOGIES

    Directory of Open Access Journals (Sweden)

    Oana Potârnichie

    2012-03-01

    Full Text Available Introduction: A comprehensive, recent analysis on the topic reached the conclusion that oxidative stress is the main cause provoking destruction of the periodontal tissue resulting from the host-microbe interaction. Scope of the study: To investigate the correlation between periodontal health condition and the seric levels of some antioxidants. Materials and method: A representative group of 58 patients, with ages between 30 and 70 years, were examined, between 2010-2011, as to their periodontal condition, after which peripheric blood was taken over and retinol, α -tocopherol, γ-tocopherol, α-caroten, β-caroten, ß-criptoxantine, zeaxantine, luteine and licopen were extracted from the serum. The values of the antioxidants were measured by high-performance chromatographic liquid technique. Results: The levels of α and β-caroten, β-criptoxantine and zeaxantine were significantly lower in the patients with minimum periodonthopaty debut (p<0.001, as well as in those with increased intensity of periodontopathy debut. β-caroten and β-criptoxantine were the only antioxidants associated with a higher risk of severe periodontic pathologies. Conclusions: The low levels registered for some carotinoides, especially β-caroten and β-criptoxantine, are directly proportional with a higher prevalence of periodonthy installation.

  16. Clinical Observation on Treatment of 43 Cases of Diabetic Vesical Pathological Changes by Needle-warming Moxibustion

    Institute of Scientific and Technical Information of China (English)

    LIU Bo; DENG Xiao-hua; CHEN Hong-tao; SU Chang-ming; HUANG Guo-qi

    2004-01-01

    By the needle-warming moxibustion, 43 cases of diabetic vesical pathological changes,together with 43 cases in the control group, were treated for 30 days, to observe the times of urination,volume of urine and residual urine inside the bladder before and after treatment every day. It has been indicated in observation that needle-warming acupuncture therapy can decrease the time of urination every day, elevate the urine volume each time and decrease the residual urine in the bladder, with a significant difference (P>0.05) in comparison with before the treatment.%运用温针灸治疗糖尿病性膀胱病变43例,设对照组43例,共治疗30d.分别于治疗前后观察每日排尿次数、每次尿量、膀胱残余尿量.观察结果表明温针灸疗法能够减少每日排尿次数,提高每次尿量,减少膀胱残余尿量,同治疗前相比差异显著(P>0.05).

  17. The effect of age in breast conserving therapy: A retrospective analysis on pathology and clinical outcome data

    International Nuclear Information System (INIS)

    Background and propose: Age is an important prognostic marker of patient outcome after breast conserving therapy; however, it is not clear how age affects the outcome. This study aimed to explore the relationship between age with the cell quantity and the radiosensitivity of microscopic disease (MSD) in relation to treatment outcome. Materials and methods: We employed a treatment simulation framework which contains mathematic models for describing the load and spread of MSD based on a retrospective cohort of breast pathology specimens, a surgery simulation model for estimating the remaining MSD quantity and a tumor control probability model for predicting the risk of local recurrence following radiotherapy. Results: The average MSD cell quantities around the primary tumor in younger (age ⩽ 50 years) and older patients were estimated at 1.9 ∗ 108 cells and 8.4 ∗ 107 cells, respectively (P < 0.01). Following surgical simulation, these numbers decreased to 2.0 ∗ 107 cells and 1.3 ∗ 107 cells (P < 0.01). Younger patients had smaller average surgical resection volume (118.9 cm3) than older patients (162.9 cm3, P < 0.01) but larger estimated radiosensitivity of MSD cells (0.111 Gy−1 versus 0.071 Gy−1, P < 0.01). Conclusion: The higher local recurrence rate in younger patients could be explained by larger clonogenic microscopic disease cell quantity, even though the microscopic disease cells were found to be more radiosensitive

  18. Pathological gambling

    Science.gov (United States)

    ... to a gambling habit. Stressful situations can worsen gambling problems. ... to avoid letting other people know about their problem. The American Psychiatric Association defines pathological gambling as having five or more of the following ...

  19. Clinical and pathological analyses of medullary cystic kidney disease%肾髓质囊肿病的临床病理分析

    Institute of Scientific and Technical Information of China (English)

    梁或; 陈育青; 王素霞; 刘颖; 鄂洁; 张宏

    2011-01-01

    Objectives Medullary cystic kidney disease (MCKD) is a tubulointerstitial nephropathy leading to end-stage renal failure. We combine the clinical and pathological characteristics as well as laboratory examinations to discuss the diagnosis of MCKD. Methods A total of 156 individuals with tubulointerstitial nephropathy were assigned into 3 groups, acute tubulointerstitial nephropathy (ATIN), chronic tubulointerstitial nephropathy (CTIN) and MCKD. Clinical data and pathological findings were analyzed. Immunohistochemistry staining of uromodulin was performed for MCKD cases. Urinary uromodulin concentrations in MCKD and 99 healthy people were tested by ELISA. Results The age at diagnosis was much younger in MCKD than in CTIN. Serum uric acid level was significantly higher in MCKD than in CTIN patients (P=0.011). Uromodulin staining by immunohis-tochemistry showed block mass and dense stain in tubular cells, while it was diffused in cytoplasm with apical reinforce in normal controls. Urinary uromodulin concentration was much lower in MCKD (P=0.047). Conclusions MCKD as one cause of tubulointerstitial nephropathy should not be ignored. Clinical data, pathological and laboratory examinations are useful for its diagnosis.%目的 探讨肾髓质囊肿病的诊断和病理特点.方法 156例病理诊断为肾小管间质肾病患者分为急性肾小管间质肾病(acute tubulointerstitial nephropathy,ATIN)组、慢性肾小管间质肾病(chronic tubulointerstitial nephropathy,CTIN)组和肾髓质囊肿病(medullary cystic kidney disease,MCKD)组,分析临床和病理,肾组织尿调蛋白染色,测定尿中尿调蛋白(uromodulin,UMOD)水平.结果 MCKD组发病年龄小,血尿酸高于CTIN组(P=0.011),UMOD呈团块状分布在小管上皮细胞内,与正常的均质状分布不同.尿UMOD低于对照(P=0.047).结论 MCKD诊断应结合临床病理及尿调蛋白的染色及尿中水平的测定.

  20. The diagnosis and management of pre-invasive breast disease: Flat epithelial atypia – classification, pathologic features and clinical significance

    International Nuclear Information System (INIS)

    Flat epithelial atypia is a descriptive term that encompasses lesions of the breast terminal duct lobular units in which variably dilated acini are lined by one to several layers of epithelial cells, which are usually columnar in shape and which display low-grade cytologic atypia. Observational studies have suggested that at least some of these lesions may represent either a precursor of ductal carcinoma in situ (DCIS) or the earliest morphological manifestation of DCIS. In contrast, the limited available clinical follow-up data suggest that the risk of both local recurrence and progression of these lesions to invasive cancer is extremely low, supporting the notion that categorizing such lesions as 'clinging carcinoma' and managing them as if they were fully developed DCIS will result in overtreatment of many patients. Additional studies are needed to better understand the biological nature and clinical significance of these lesions

  1. Primary alveolar capillary dysplasia (acinar dysplasia) and surfactant protein B deficiency: a clinical, radiological and pathological study

    Energy Technology Data Exchange (ETDEWEB)

    Hugosson, Claes O.; Khoumais, Nuha [King Faisal Specialist Hospital and Research Centre, Department of Radiology MBC 28, Riyadh (Saudi Arabia); Salama, Husam M.; Kattan, Abdul H. [King Faisal Specialist Hospital and Research Centre, Department of Paediatrics, Riyadh (Saudi Arabia); Al-Dayel, Fouad [King Faisal Specialist Hospital and Research Centre, Department of Pathology, Riyadh (Saudi Arabia)

    2005-03-01

    Full-term infants with severe and prolonged respiratory distress represent a diagnostic challenge. Plain radiographic findings may be nonspecific or similar to classic surfactant deficiency disease for infants with surfactant protein B deficiency and acinar dysplasia. Objectives: To describe the similar clinical-radiolgical patterns of two rare neonatal conditions. Six newborn babies with severe respiratory distress at birth demonstrated clinical and radiographically prolonged and progressive diffuse pulmonary opacification. All infants demonstrated hyperinflation of the lungs. The diffuse hazy opacification, which varied from mild (n=3) to moderate (n=3), progressed to severe diffuse opacification preceding death, which occurred at 12-36 days of life. Open lung biopsy confirmed the diagnosis of primary alveolar acinar dysplasia (AD) in four infants and surfactant protein B deficiency (SPBD) in two infants. In full-term babies with unexplained progressive respiratory distress from birth and progress of radiological changes, both AD and SPBD should be considered. (orig.)

  2. Primary alveolar capillary dysplasia (acinar dysplasia) and surfactant protein B deficiency: a clinical, radiological and pathological study

    International Nuclear Information System (INIS)

    Full-term infants with severe and prolonged respiratory distress represent a diagnostic challenge. Plain radiographic findings may be nonspecific or similar to classic surfactant deficiency disease for infants with surfactant protein B deficiency and acinar dysplasia. Objectives: To describe the similar clinical-radiological patterns of two rare neonatal conditions. Six newborn babies with severe respiratory distress at birth demonstrated clinical and radiographically prolonged and progressive diffuse pulmonary opacification. All infants demonstrated hyperinflation of the lungs. The diffuse hazy opacification, which varied from mild (n=3) to moderate (n=3), progressed to severe diffuse opacification preceding death, which occurred at 12-36 days of life. Open lung biopsy confirmed the diagnosis of primary alveolar acinar dysplasia (AD) in four infants and surfactant protein B deficiency (SPBD) in two infants. In full-term babies with unexplained progressive respiratory distress from birth and progress of radiological changes, both AD and SPBD should be considered. (orig.)

  3. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland: The current nomenclature, clinical/pathological characteristics and management.

    Science.gov (United States)

    Daniele, Luca; Nikolarakos, Dimitrios; Keenan, Jonathon; Schaefer, Nathan; Lam, Alfred King-Yin

    2016-06-01

    Clear cell carcinoma, not otherwise specified (NOS)/hyalinising clear cell carcinoma (HCCC) is a rare entity in salivary gland tumour. The aim of the research is to review the current concepts and characteristics of this carcinoma. The clinical and pathological data of the disease obtained from literature and two original cases were analysed. Overall, 152 cases were reviewed up to the year 2014. The carcinomas were noted often in woman, in the seventh decade of life, located in oral cavity and as early-stages cancers. On pathological examination, they were characterized by tumour cells having clear cell morphology with hyalinised stroma. Immunohistochemical studies revealed that the carcinoma is positive for cytokeratin and negative for myoepithelial differentiation. EWSR1-ATF1 fusion is specific for the carcinoma. Also, 9% of the reported cases had local nodal metastasis, with 6 cases demonstrating distant metastases at presentation. On follow-up, 22% of patients had recurrent or with persistent diseases after surgery. The time for the first recurrence could be as long as 24 years. Risk factors for recurrence include advanced stage at diagnosis and metastases at presentation. To conclude, HCCC is a low grade malignancy but have the potential for local metastases, recurrence, distant metastases and cancer-related death. PMID:27150676

  4. Powerful qPCR assays for the early detection of latent invaders: interdisciplinary approaches in clinical cancer research and plant pathology.

    Science.gov (United States)

    Luchi, Nicola; Capretti, Paolo; Pazzagli, Mario; Pinzani, Pamela

    2016-06-01

    Latent invaders represent the first step of disease before symptoms occur in the host. Based on recent findings, tumors are considered to be ecosystems in which cancer cells act as invasive species that interact with the native host cell species. Analogously, in plants latent fungal pathogens coevolve within symptomless host tissues. For these reasons, similar detection approaches can be used for an early diagnosis of the invasion process in both plants and humans to prevent or reduce the spread of the disease. Molecular tools based on the evaluation of nucleic acids have been developed for the specific, rapid, and early detection of human diseases. During the last decades, these techniques to assess and quantify the proliferation of latent invaders in host cells have been transferred from the medical field to different areas of scientific research, such as plant pathology. An improvement in molecular biology protocols (especially referring to qPCR assays) specifically designed and optimized for detection in host plants is therefore advisable. This work is a cross-disciplinary review discussing the use of a methodological approach that is employed within both medical and plant sciences. It provides an overview of the principal qPCR tools for the detection of latent invaders, focusing on comparisons between clinical cancer research and plant pathology, and recent advances in the early detection of latent invaders to improve prevention and control strategies. PMID:27112348

  5. Relationship between expression of leptin receptors mRNA in breast tissue, plasma leptin level in breast cancer patients with obesity and clinical pathologic data

    International Nuclear Information System (INIS)

    In order to investigate the expression of leptin receptors mRNA in breast tissue and plasma leptin levels in breast cancer patients with obesity and their relationship with clinical pathologic data, 124 subjects who were either obesity or had suffered from breast benign disease with obesity, or breast cancer with obesity were entered into this study. The levels of plasma leptin in all subjects were determined and leptin receptors mRNA expression levels were measured by RT-PCR in breast tissue of breast cancer patients with obesity and breast benign disease with obesity. The results showed that plasma leptin levels in breast cancer patients with obesity were significantly higher than those in breast benign disease with obesity and obesity patients alone (P<0.05). The expression of the leptin receptor long form [-Lep-R(L)-] mRNA and the leptin receptor short form [-Lep-R(S)-] mRNA in breast tissue of breast cancer patients with obesity were significantly higher than that in breast tissue of breast benign disease patients with obesity (P<0.05). The plasma leptin level had remarkable positive correlation with the expressions of the Lep-R(L) mRNA and the Lep-R(S) mRNA. The plasma leptin level and leptin receptors mRNA expression levels in patients were not correlated with the axillary node metastasis, menopause, the TNM stage or pathological type. Therefore, leptin may have a promoting effect on the carcinogenesis of breast cancer. (authors)

  6. The complex of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex): imaging findings with clinical and pathological correlation

    OpenAIRE

    Courcoutsakis, Nikos A.; Tatsi, Christina; Patronas, Nicholas J.; Lee, Chiy-Chia Richard; Prassopoulos, Panos K.; Stratakis, Constantine A.

    2013-01-01

    The complex of myxomas, spotty skin pigmentation and endocrine overactivity, or Carney complex (CNC), is a familial multiple endocrine neoplasia and lentiginosis syndrome. CNC is inherited in an autosomal dominant manner and is genetically heterogeneous. Its features overlap those of McCune-Albright syndrome and other multiple endocrine neoplasia (MEN) syndromes. Spotty skin pigmentation is the major clinical manifestation of the syndrome, followed by multicentric heart myxomas, which occur a...

  7. STUDY OF CLINICAL PROFILE OF NON - TOXIC GOITER WITH SPECIAL REFERENCE TO CORRELATION OF PATHOLOGY, LIPID PROFILE AND ANTIBODY LEVEL

    Directory of Open Access Journals (Sweden)

    Santanu

    2014-11-01

    Full Text Available OBJECTIVE : To evaluate the morphology of non - toxic goiter , the role of auto - immunity and lipid abnormalities in overt and sub - clinical hypothyroid goiter patients. METHODS: A descriptive observational study was undertaken amongst goiter patients without thyrotoxic features comprising 50 randomly selected cases within the range of 12 - 65years. Goiter patients with thyrotoxic features , acute illness and other visceral diseases were excluded. The patients were evaluated with thyroid function tests , USG - thyroid , FNAC - thyroid , anti - TPO and lipid profile after thorough clinical examination. RESULTS : In my study , most patients were female (with male: female ratio 1:5.25 and were middle aged (betwe en age group 30 - 49years. Among all patients 60 %( i.e . 30 patients had Hashimoto’s thyroiditis , 24% (i.e. 12 patients had diffuse colloid goiter and 16% (i.e. 8 patients had nodular goiter. 52% (i.e. 26 of all patients and 76.6% (i.e. 23 of Hashimoto ’s goiter patients were anti - TPO positive. Majority of colloid goiter (i.e. 66.7% and nodular goiter (50% patients were euthyroid but majority of Hashimoto’s goiter patients were hypothyroid (65.38% overt and 33% sub - clinical. Majority of anti - TPO posit ive patients were hypothyroid (65.38% overt and 30.62% sub - clinical and majority of anti - TPO negative patients (66.67% were euthyroid. Within reference range of TSH , there was a linear increase in total serum cholesterol , LDL - cholesterol , triglyceride an d decrease in HDL - cholesterol with increase in TSH. This lipid profile changes are mainly seen in Hashimoto goiter patients . CONCLUSION : this study emphasizes the role of auto - immunity in non - toxic goiter patients especially Hashimoto’s thyroiditis patient s and lipid profile changes in those patients.

  8. Adaptation to prolonged bedrest in man: A compendium of research. [bibliographies on clinical medicine and human pathology

    Science.gov (United States)

    Greenleaf, J. E.; Greenleaf, C. J.; Vanderveer, D.; Dorchak, K. J.

    1976-01-01

    A compilation of major studies that describe the clinical observations and elucidate the physiological mechanisms of the adaptive process of man undergoing prolonged bed rest is presented. Additional studies are included that provide background information in the form of reviews or summaries of the process. Wherever possible a detailed annotation is provided under the subheadings: (1) purpose, (2) procedure and methods, (3) results, and (4) conclusions. Additional references are provided in a selected bibliography.

  9. Clinical and Pathological Investigation on Turkey Diseases in North-central City of Jos, Nigeria, 2009-2014

    OpenAIRE

    Olatunde Babatunde Akanbi; Christiana Ibironke Odita; Philip Adeokemola Okewole; Christopher Jerry Bot; Adebowale Obalisa; Ezekiel Gyang Pam; Dakyahas John; Johnson Shallmizhili; Gabriel Ijale; Bulus Alim

    2015-01-01

    Information on turkey production and disease is rare in Nigeria, possibly because turkeys are seldom raised commercially. Also, turkeys require intensive husbandry and health care after hatching, which backyard poultry producers hardly provided especially, when raised in a disease endemic environment. In an attempt to document the diseases militating against turkey production in Nigeria, clinical and necropsy records were reviewed from veterinary practices in Jos and the Central Diagnostic La...

  10. Studies on Clinical Aspects, Pathological Changes, Immunohistochemistry, 14-3-3 protein, PrP Gene, and Animal Transmission of Creutzldt-Jakob Disease in China

    Institute of Scientific and Technical Information of China (English)

    Lin Shilie; Zhao Jiexu; Jiang Xinmei; Song Xiaonan; Wang Weimin; Fan Yengyeng; Tao Yuiqin; Chen Xiuyun

    2000-01-01

    Objectives To investigate the clinical manifestations, pathological changes, expression of PrP gene, 14-3-3 protein in cerebrospinal fluid (CSF) and experimental animal transmission of Creuizfeldt-Jakob disease (CJD) in China. Methods Clinical aspects of 24 patients with CJD which was confirmed neuropathological were evaluated. Brain sections of 10 cases of them were given immunostaining with antiserum to a synthetic polypeptide of prioni protein (PrP). PrP gene was analyzed in 10 cases, and 14-3-3 protein in CSF was detected in 5 cases. Experimental mouse transmission was carried out using brain suspension from 7 patients with CJD. Results 1) Nineteen cases with sporadic CJD, 3 cases with iatrogenic CJD, 1 case with inherited CJD and 1 case with coexistence of Alzheimer disease(AD) and CJD were found. 2) The percentage of acute and subacute onset was high up to 96%. The illness duration was shorter in a subacute onset and the brain atrophy was not obvious.3) The synaptic type of PrP deposition was shown in paraffin sections in all -cases by immunostaining.4) 14-3-3 protein was detected in 5 eases in cerebrospinal fluid with CJD 5) Spongiform degeneration and PrP deposition could be shown in the brain sections of experimental mouse transmission. Conclusion There are special characteristics in clinical aspects of CJD in China. The detection of 14-3-3 protein can provide objective evidence for early diagnosis of CJD in order to prevent its transmission

  11. A Prospective Pathologic Study to Define the Clinical Target Volume for Partial Breast Radiation Therapy in Women With Early Breast Cancer

    International Nuclear Information System (INIS)

    Purpose: To determine an appropriate clinical target volume for partial breast radiation therapy (PBRT) based on the spatial distribution of residual invasive and in situ carcinoma after wide local excision (WLE) for early breast cancer or ductal carcinoma in situ (DCIS). Methods and Materials: We performed a prospective pathologic study of women potentially eligible for PBRT who had re-excision and/or completion mastectomy after WLE for early breast cancer or DCIS. A pathologic assessment protocol was used to determine the maximum radial extension (MRE) of residual carcinoma from the margin of the initial surgical cavity. Women were stratified by the closest initial radial margin width: negative (>1 mm), close (>0 mm and ≤1 mm), or involved. Results: The study population was composed of 133 women with a median age of 59 years (range, 27-82 years) and the following stage groups: 0 (13.5%), I (40.6%), II (38.3%), and III (7.5%). The histologic subtypes of the primary tumor were invasive ductal carcinoma (74.4%), invasive lobular carcinoma (12.0%), and DCIS alone (13.5%). Residual carcinoma was present in the re-excision and completion mastectomy specimens in 55.4%, 14.3%, and 7.2% of women with an involved, close, and negative margin, respectively. In the 77 women with a noninvolved radial margin, the MRE of residual disease, if present, was ≤10 mm in 97.4% (95% confidence interval 91.6-99.5) of cases. Larger MRE measurements were significantly associated with an involved margin (P30 mm (P=.03), premenopausal status (P=.03), and negative progesterone receptor status (P=.05). Conclusions: A clinical target volume margin of 10 mm would encompass microscopic residual disease in >90% of women potentially eligible for PBRT after WLE with noninvolved resection margins.

  12. A nation-wide multicenter retrospective study of the epidemiological, pathological and clinical characteristics of breast cancer in situ in Chinese women in 1999 - 2008.

    Directory of Open Access Journals (Sweden)

    Yanan Kong

    Full Text Available BACKGROUND: Compared with invasive breast cancer, breast cancer in situ (BCIS is seldom life threatening. However, an increasing incidence has been observed in recent years over the world. The purpose of our study is to investigate the epidemiological, clinical and pathological profiles of BCIS in Chinese women from 1999-2008. METHODS: Four thousand and two hundred-eleven female breast cancer (BC patients were enrolled in this hospital-based nation-wide and multi-center retrospective study. Patients were randomly selected from seven hospitals in seven representative geographical regions of China between 1999 and 2008. The epidemiological, clinical and pathological data were collected based on the designed case report form (CRF. RESULTS: There were one hundred and forty-three BCIS cases in four thousand and two hundred-eleven BC patients (3.4%. The mean age at diagnosis was 48.3 years and BCIS peaked in age group 40-49 yrs (39.9%. The most common subtype was ductal carcinoma in situ (DCIS (88.0%. 53.8% were positive for estrogen receptor (ER. Human epidermal growth factor receptor 2 (HER2 positive status was observed in 23.8% of patients. All patients underwent surgeries and 14.7% of them had breast conservation therapies (BCT (21/143, but 41.9% accepted chemotherapy (64/143. Much less patients underwent radiotherapy (16.0%, 23/143 and among patients who had BCT, 67% accepted radiotherapy (14/21. Endocrine therapy was taken in 44.1% patients (63/143. CONCLUSIONS: The younger age of BCIS among Chinese women than Western countries and increasing number of cases pose a great challenge. BCT and endocrine therapy are under great needs.

  13. A Prospective Pathologic Study to Define the Clinical Target Volume for Partial Breast Radiation Therapy in Women With Early Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Brandon T., E-mail: Brandon.Nguyen@act.gov.au [Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Canberra Hospital, Radiation Oncology Department, Garran, ACT (Australia); Deb, Siddhartha [Department of Anatomical Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Victorian Cancer Biobank, Cancer Council of Victoria, Carlton, Victoria (Australia); Fox, Stephen [Department of Anatomical Pathology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Hill, Prudence [Department of Anatomical Pathology, St. Vincent' s Hospital Melbourne, Fitzroy, Victoria (Australia); Collins, Marnie [Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Chua, Boon H. [Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); University of Melbourne, Parkville, Victoria (Australia)

    2012-12-01

    Purpose: To determine an appropriate clinical target volume for partial breast radiation therapy (PBRT) based on the spatial distribution of residual invasive and in situ carcinoma after wide local excision (WLE) for early breast cancer or ductal carcinoma in situ (DCIS). Methods and Materials: We performed a prospective pathologic study of women potentially eligible for PBRT who had re-excision and/or completion mastectomy after WLE for early breast cancer or DCIS. A pathologic assessment protocol was used to determine the maximum radial extension (MRE) of residual carcinoma from the margin of the initial surgical cavity. Women were stratified by the closest initial radial margin width: negative (>1 mm), close (>0 mm and {<=}1 mm), or involved. Results: The study population was composed of 133 women with a median age of 59 years (range, 27-82 years) and the following stage groups: 0 (13.5%), I (40.6%), II (38.3%), and III (7.5%). The histologic subtypes of the primary tumor were invasive ductal carcinoma (74.4%), invasive lobular carcinoma (12.0%), and DCIS alone (13.5%). Residual carcinoma was present in the re-excision and completion mastectomy specimens in 55.4%, 14.3%, and 7.2% of women with an involved, close, and negative margin, respectively. In the 77 women with a noninvolved radial margin, the MRE of residual disease, if present, was {<=}10 mm in 97.4% (95% confidence interval 91.6-99.5) of cases. Larger MRE measurements were significantly associated with an involved margin (P<.001), tumor size >30 mm (P=.03), premenopausal status (P=.03), and negative progesterone receptor status (P=.05). Conclusions: A clinical target volume margin of 10 mm would encompass microscopic residual disease in >90% of women potentially eligible for PBRT after WLE with noninvolved resection margins.

  14. Clinical observations, pathology, bioassay in mice and serological response at slaughter in pigs experimentally infected with Toxoplasma gondii

    DEFF Research Database (Denmark)

    Wingstrand, Anne; Lind, Peter; Haugegaard, J.;

    1997-01-01

    Experimental infections of a total of 47 pigs with tachyzoites of the Toxoplasma gondii RH-strain, tissue cysts of the SSI-119 and R92 strains as well as oocysts of the SSI-119 strain were performed to determine the sensitivity of an indirect IgG-ELISA, using tachyzoite lysate of the RH......-strain as antigen. The infections led to a dose dependent moderate clinical affection (inappetence, fever and poor general condition). Pigs infected with 10000 oocysts or with 1/2 mouse brain containing tissue cysts of the SSI-119 strain showed a significant decrease in weight gain compared to uninoculated pigs...

  15. Clinical observations, pathology, bioassay in mice and serological response at slaughter in pigs experimentally infected with Toxoplasma gondii

    DEFF Research Database (Denmark)

    Wingstrand, Anne; Lind, Peter; Haugegaard, J.; Henriksen, Sv. Aa.; Bille-Hansen, Vivi; Sørensen, Vibeke

    1997-01-01

    Experimental infections of a total of 47 pigs with tachyzoites of the Toxoplasma gondii RH-strain, tissue cysts of the SSI-119 and R92 strains as well as oocysts of the SSI-119 strain were performed to determine the sensitivity of an indirect IgG-ELISA, using tachyzoite lysate of the RH-strain as...... antigen. The infections led to a dose dependent moderate clinical affection (inappetence, fever and poor general condition). Pigs infected with 10000 oocysts or with 1/2 mouse brain containing tissue cysts of the SSI-119 strain showed a significant decrease in weight gain compared to uninoculated pigs...

  16. Arsenic Induced Toxicity in Broiler Chicks and Its Amelioration with Ascorbic Acid: Clinical, Hematological and Pathological Study

    Directory of Open Access Journals (Sweden)

    Rabia Sharaf, Ahrar Khan*, Muhammad Zargham Khan, Iftikhar Hussain, Rao Zahid Abbas, S. T. Gul, Fazal Mahmood and Muhammad Kashif Saleemi

    2013-07-01

    Full Text Available This study was conducted to observe the arsenic (As toxicity lesions in birds and to know either Vit C ameliorates these toxic effects or not. One-day-old broilers chicks (n=72 procured from a local hatchery were randomly divided into four equal groups. First group was kept as control and second group was given As (50 mg/kg BW via crop tubing. Third group received in addition to As, Vit C (250 mg/kg BW whereas fourth group received only Vit C. Killing by neck dislocation of randomly selected six birds from each group was carried out on experimental days 0, 16 and 32 for collection of blood and tissues specimens. Arsenic treated birds showed clinical signs of toxicity throughout the experiment than all other groups. These clinical signs included decreased body weight and feed intake, dullness, open mouth breathing, increased thirst, ruffled feathers, pale comb, skin irritation and watery diarrhea which were not significant in any other group. As treated group showed a significant (P<0.05 decrease in hematological parameters. Severe gross and histopathological changes were observed in intestines, spleen and lungs of birds fed with As than all other groups. Decreased height of villi of middle portion of small intestines was also observed in As treated birds. Villi height in Vit C treated group increased as compared to control group. It was concluded that As induces severe toxic effects in broiler birds; however, these toxic effects can be partially ameliorated by Vit C.

  17. Clinical and Pathological Investigation on Turkey Diseases in North-central City of Jos, Nigeria, 2009-2014

    Directory of Open Access Journals (Sweden)

    Olatunde Babatunde Akanbi

    2015-12-01

    Full Text Available Information on turkey production and disease is rare in Nigeria, possibly because turkeys are seldom raised commercially. Also, turkeys require intensive husbandry and health care after hatching, which backyard poultry producers hardly provided especially, when raised in a disease endemic environment. In an attempt to document the diseases militating against turkey production in Nigeria, clinical and necropsy records were reviewed from veterinary practices in Jos and the Central Diagnostic Laboratory of the National Veterinary Research Institute (NVRI, Vom, Nigeria between 2009 - 2014. A total of 306 turkeys from backyard flocks were presented to the Veterinary clinics between 2009-2014 with various health complaints by backyard flock owners. Viral (Pox and Newcastle disease and parasitic (Helminthosis, Coccidiosis and Ectoparasitism diseases were mostly diagnosed. During the same period, 42 samples comprising 25 carcasses and 17 cloacal swabs were submitted for post mortem examination, virus isolation and microbiological test. Colisepticaemia, colibacillosis, pullorum disease, airsacculitis and infectious sinusitis are the main diseases diagnosed at post-mortem examination and microbiological test, while none of the samples were positive for influenza by virus isolation. It was observed that turkey rearing was small-scaled and kept as backyard poultry in North-central Nigeria. It can therefore be concluded from this study that turkeys raised in north-central city of Jos are affected by diseases ranging from viral to bacterial and parasitic, which can adversely affect productivity. This can therefore be improved upon by controlling the diseases mostly affecting turkeys.

  18. New aspects of clinical pathology and electro-physiological muscle disturbances in patients with history of trichinellosis

    Directory of Open Access Journals (Sweden)

    Kociecka W.

    2001-06-01

    Full Text Available Clinical studies performed in 44 patients, one, three, four, six or seven years after they had experienced trichinellosis demonstrated the persistence of various general and motor ailments in 88.7 % of the patients. The persisting for many years antibodies against E/S antigen of Trichinella in 86.4 % of examined patients seem to reflect chronic stimulation by the larvae which, as shown by parasitological and histopathological tests, survived longer and underwent gradual destruction in muscles. Bio-electric disturbances in muscles were most frequently of a mixed type, with prevalence of a neural type record. These observations illustrate a disturbed function of motor neurones and of impulse transmission at the myoneural junction in patients chronically infected with Trichinella.

  19. Occult inflammatory breast cancer: review of clinical, mammographic, US and pathologic signs; Carcinoma infiammatorio occulto della mammella: revisione di reperti mammografici, ecografici, clinici ed anatomo-patologici

    Energy Technology Data Exchange (ETDEWEB)

    Cumo, Francesca; Gaioni, Maria Berenice; Bonetti, Franco; Manfrin, Erminia; Remo, Andrea; Pattaro, Christian [Policlinico G.B. Rossi, Verona (Italy). Dipartimento di scienze morfologico biomediche; Policlinico G.B. Rossi, Verona (Italy). Sezione di radiologia, Sezione di anatomia patologica. Dipartimento di medicina e sanita' pubblica, Sezione di epidemiologia e statistica medica, igiene

    2005-04-01

    Purpose: To examine the clinical, radiologic and pathologic findings of occult inflammatory breast cancer (OIBC) in order to identify features useful for diagnosis. Materials and methods: We retrospectively reviewed the records of 19 women with OIBC observed at our Department between 1992 and 2001. We analysed the clinical history, mammographic, ultrasonographic, and pathologic findings and investigated overall survival (OS), prognostic variables and radio-pathologic correlations. Results: The most common mammographic findings were: diffusely density (52.63%), trabecular thickening (42.1%), mass (36.84%). The most common US findings were axillary lymphadenopathy (68,75%), skin thickening (43.75%) and mass (56.25%). At least one inflammatory sign was found in 14 women (74%) at mammography (subcutaneous thickening, trabecular thickening, diffuse increase of density) or at US (subcutaneous thickening, diffuse increase in echogenicity due to oedema, lymph vessel dilatation). Estrogen receptors (ER) were present in 63.2% and Progesterone receptors (PgR) in 36.8%. Significant prognostic variables were ER and Ki 67. Conclusions: The typical radiological pattern of clinical inflammatory breast carcinoma is less frequently present in OIBC; nevertheless the radiologist must pay attention because frequently OIBC presents just one radiological sign and this should be enough for a diagnostic suspicion. Moreover, the absence of clinical and radiological inflammatory signs does not exclude inflammatory breasts cancer because OIBC can manifest at imaging as a mass or isolated calcification. ER and PgR are positive in a high percentage of patients and confirm that OIBC has a better prognosis that clinical inflammatory breast cancer. [Italian] Scopo: Esaminare i reperti clinici, radiologici ed anatomo-patologici del carcinoma infiammatorio occulto della mammella (IBCO) al fine di identificare alcune caratteristiche utili alla diagnosi. Materiale e metodi: E' stato effettuato

  20. Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets.

    Science.gov (United States)

    Bogusz, Agata M; Bagg, Adam

    2016-09-01

    Small B-cell lymphomas and leukemias (SBCLs) are a clinically, morphologically, immunophenotypically and genetically heterogeneous group of clonal lymphoid neoplasms, including entities such as chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma (MCL), follicular lymphoma (FL), lymphoplasmacytic lymphoma (LPL), marginal zone lymphoma (MZL) and hairy cell leukemia (HCL). The pathogenesis of some of these lymphoid malignancies is characterized by distinct translocations, for example t(11;14) in the majority of cases of MCL and t(14;18) in most cases of FL, whereas other entities are associated with a variety of recurrent but nonspecific numeric chromosomal abnormalities, as exemplified by del(13q14), del(11q22), and +12 in CLL, and yet others such as LPL and HCL that lack recurrent or specific cytogenetic aberrations. The recent surge in next generation sequencing (NGS) technology has shed more light on the genetic landscape of SBCLs through characterization of numerous driver mutations including SF3B1 and NOTCH1 in CLL, ATM and CCND1 in MCL, KMT2D and EPHA7 in FL, MYD88 (L265P) in LPL, KLF2 and NOTCH2 in splenic MZL (SMZL) and BRAF (V600E) in HCL. The identification of distinct genetic lesions not only provides greater insight into the molecular pathogenesis of these disorders but also identifies potential valuable biomarkers for prognostic stratification, as well as specific targets for directed therapy. This review discusses the well-established and recently identified molecular lesions underlying the pathogenesis of SBCLs, highlights their clinical relevance and summarizes novel targeted therapies. PMID:27121112

  1. The complex of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex): imaging findings with clinical and pathological correlation.

    Science.gov (United States)

    Courcoutsakis, Nikos A; Tatsi, Christina; Patronas, Nicholas J; Lee, Chiy-Chia Richard; Prassopoulos, Panos K; Stratakis, Constantine A

    2013-02-01

    The complex of myxomas, spotty skin pigmentation and endocrine overactivity, or Carney complex (CNC), is a familial multiple endocrine neoplasia and lentiginosis syndrome. CNC is inherited in an autosomal dominant manner and is genetically heterogeneous. Its features overlap those of McCune-Albright syndrome and other multiple endocrine neoplasia (MEN) syndromes. Spotty skin pigmentation is the major clinical manifestation of the syndrome, followed by multicentric heart myxomas, which occur at a young age and are the lethal component of the disease. Myxomas may also occur on the skin (eyelid, external ear canal and nipple) and the breast. Breast myxomas, when present, are multiple and bilateral among female CNC patients, an entity which is also described as "breast-myxomatosis" and is a characteristic feature of the syndrome. Affected CNC patients often have tumours of two or more endocrine glands, including primary pigmented nodular adrenocortical disease (PPNAD), an adrenocorticotropin hormone (ACTH)-independent cause of Cushing's syndrome, growth hormone (GH)-secreting and prolactin (PRL)-secreting pituitary adenomas, thyroid adenomas or carcinomas, testicular neoplasms (large-cell calcifying Sertoli cell tumours [LCCSCT]) and ovarian lesions (cysts and cancinomas). Additional infrequent but characteristic manifestations of CNC are psammomatous melanotic schwannomas (PMS), breast ductal adenomas (DAs) with tubular features, and osteochondromyxomas or "Carney bone tumour". Teaching Points • Almost 60 % of the known CNC kindreds have a germline inactivating mutations in the PRKAR1A gene. • Spotty skin pigmentation is the major clinical manifestation of CNC, followed by heart myxomas. • Indicative imaging signs of PPNAD are contour abnormality and hypodense spots within the gland. • Two breast tumours may present in CNC: myxoid fibroadenomas (breast myxomatosis) and ductal adenomas. • Additional findings of CNC are psammomatous melanotic schwannomas

  2. Digital pathology

    CERN Document Server

    Sucaet, Yves

    2014-01-01

    Digital pathology has experienced exponential growth, in terms of its technology and applications, since its inception just over a decade ago. Though it has yet to be approved for primary diagnostics, its values as a teaching tool, facilitator of second opinions and quality assurance reviews and research are becoming, if not already, undeniable. It also offers the hope of providing pathology consultant and educational services to under-served areas, including regions of the world that could not possibly sustain this level of services otherwise. And this is just the beginning, as its adoption b

  3. Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model

    Directory of Open Access Journals (Sweden)

    M.T. Tillmann

    2014-12-01

    Full Text Available While Triticum sp. has been shown to act in wound healing, stimulating collagen synthesis by fibroblasts, the use of this plant extract has yet to be assessed in vivo, in commercially viable presentations. This study used rabbits and assessed, on days seven, 14, and 21, the presence or absence of granulation tissue and epithelialization, histopathological structures, and scar quality through the breaking and tension strength. Treatments, performed for 21 days, were aqueous extract of T. aestivum at a concentration of 2mg/mL (group I and 10mg/mL (group II and a nonionic cream (control group. We demonstrate that the formation of granulation tissue was not significantly different between treatments. In the analysis of epithelial tissue, wounds in group II differed from other treatments by day 7. On days 14 and 21 there was no significant clinical difference between groups. In the histopathological evaluation, scar quality and rupture strength did not differ between the groups in the studied period. In the tension strength evaluation, group I differed from the others, presenting a higher tension strength overall. The studied treatments did not differ regarding healing evolution of the skin wounds, but T. aestivum extract, at 2mg/mL, presents better results in the tension strength evaluation.

  4. Effects of dietary ABATE? on reproductive success, duckling survival, behavior, and clinical pathology in game-farm mallards

    Science.gov (United States)

    Franson, J.C.; Spann, J.W.; Heinz, G.H.; Bunck, C.M.; Lamont, T.

    1983-01-01

    Forty-four pairs of game-farm mallards (Anas platyrhynchos) were fed ABATE? E (temephos) to yield 0, 1, or 10 ppm ABATE? beginning before the initiation of lay, and terminating when ducklings were 21 days of age. The mean interval between eggs laid was greater for hens fed 10 ppm ABATE? than for controls. Clutch size, fertility, hatchability, nest attentiveness of incubating hens, and avoidance behavior of ducklings were not significantly affected by ABATE? ingestion. The percentage survival of ducklings to 21 days of age was significantly lower in both treated groups than in controls, but brain acetylcholinesterase (AChE) activity was not inhibited in young which died before termination of the study. In 21-day-old ducklings, aspartate aminotransferase (AST) activity increased and plasma nonspecific cholinesterase (ChE) activity was inhibited by about 20% in both treatment groups, but there were no significant differences in brain AChE or plasma alanine aminotransferase (ALT) activities, or plasma uric acid concentration. Clinical chemistry values of adults were not affected. No ABATE?, ABATE? sulfoxide, or ABATE? sulfone residues were found in eggs or tissue samples.

  5. Neuronal ceroid-lipofuscinosis, a type of amaurotic family idiocy: clinical and pathological study of four cases

    Directory of Open Access Journals (Sweden)

    Luciano de Souza Queiroz

    1974-03-01

    Full Text Available Neuronal ceroid-lipofuscinosis (NCL is a recent term, proposed for acurate designation of the late-onset types of Amaurotic Family Idiocy (AFI. Histopathology shows ubiquitous intraneuronal accumulation of lipopigments, being the most important factor for characterization of the entity at present time. Biochemical changes and pathogenesis are obscure. NCL is in contrast to the infantile type of AFI (Tay-Sachs disease, in which intraneuronal accumulation of gangliosides (sphingolipids is due to the well known deficiency of a lysosomal enzyme. The authors report on four cases of NCL, two brothers of the late infantile (Jansky-Bielschowsky type and a brother and a sister of the juvenile (Spielmeyer-Sjögren type. One autopsy and three cortical biopsies revealed moderate to severe distention of the neurons by lipopigment, with nerve cell loss, gliosis and cerebral atrophy. Lipopigment was also increased in liver, heart and spleen. The patients were the first in Brazilian literature in whom the storage material was identified as lipopigment by histochemical methods. A brief summary of the clinical features of NCL is presented, and relevant problems are discussed, concerning interpretation of the nature of the storage material, and significance of the disease for gerontological research.

  6. TU-C-12A-09: Modeling Pathologic Response of Locally Advanced Esophageal Cancer to Chemo-Radiotherapy Using Quantitative PET/CT Features, Clinical Parameters and Demographics

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, H; Chen, W; Kligerman, S; D’Souza, W; Suntharalingam, M; Lu, W [University of Maryland School of Medicine, Baltimore, MD (United States); Tan, S [Huazhong University of Science and Technology, Wuhan (China); Kim, G [Duke University, High Point, NC (United States)

    2014-06-15

    Purpose: To develop predictive models using quantitative PET/CT features for the evaluation of tumor response to neoadjuvant chemo-radiotherapy (CRT) in patients with locally advanced esophageal cancer. Methods: This study included 20 patients who underwent tri-modality therapy (CRT + surgery) and had {sup 18}F-FDG PET/CT scans before initiation of CRT and 4-6 weeks after completion of CRT but prior to surgery. Four groups of tumor features were examined: (1) conventional PET/CT response measures (SUVmax, tumor diameter, etc.); (2) clinical parameters (TNM stage, histology, etc.) and demographics; (3) spatial-temporal PET features, which characterize tumor SUV intensity distribution, spatial patterns, geometry, and associated changes resulting from CRT; and (4) all features combined. An optimal feature set was identified with recursive feature selection and cross-validations. Support vector machine (SVM) and logistic regression (LR) models were constructed for prediction of pathologic tumor response to CRT, using cross-validations to avoid model over-fitting. Prediction accuracy was assessed via area under the receiver operating characteristic curve (AUC), and precision was evaluated via confidence intervals (CIs) of AUC. Results: When applied to the 4 groups of tumor features, the LR model achieved AUCs (95% CI) of 0.57 (0.10), 0.73 (0.07), 0.90 (0.06), and 0.90 (0.06). The SVM model achieved AUCs (95% CI) of 0.56 (0.07), 0.60 (0.06), 0.94 (0.02), and 1.00 (no misclassifications). Using spatial-temporal PET features combined with conventional PET/CT measures and clinical parameters, the SVM model achieved very high accuracy (AUC 1.00) and precision (no misclassifications), significantly better than using conventional PET/CT measures or clinical parameters and demographics alone. For groups with a large number of tumor features (groups 3 and 4), the SVM model achieved significantly higher accuracy than the LR model. Conclusion: The SVM model using all features

  7. Modeling Pathologic Response of Esophageal Cancer to Chemoradiation Therapy Using Spatial-Temporal {sup 18}F-FDG PET Features, Clinical Parameters, and Demographics

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Hao [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland (United States); Tan, Shan [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland (United States); Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan (China); Chen, Wengen; Kligerman, Seth [Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland (United States); Kim, Grace; D' Souza, Warren D.; Suntharalingam, Mohan [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland (United States); Lu, Wei, E-mail: wlu@umm.edu [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland (United States)

    2014-01-01

    Purpose: To construct predictive models using comprehensive tumor features for the evaluation of tumor response to neoadjuvant chemoradiation therapy (CRT) in patients with esophageal cancer. Methods and Materials: This study included 20 patients who underwent trimodality therapy (CRT + surgery) and underwent {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) both before and after CRT. Four groups of tumor features were examined: (1) conventional PET/CT response measures (eg, standardized uptake value [SUV]{sub max}, tumor diameter); (2) clinical parameters (eg, TNM stage, histology) and demographics; (3) spatial-temporal PET features, which characterize tumor SUV intensity distribution, spatial patterns, geometry, and associated changes resulting from CRT; and (4) all features combined. An optimal feature set was identified with recursive feature selection and cross-validations. Support vector machine (SVM) and logistic regression (LR) models were constructed for prediction of pathologic tumor response to CRT, cross-validations being used to avoid model overfitting. Prediction accuracy was assessed by area under the receiver operating characteristic curve (AUC), and precision was evaluated by confidence intervals (CIs) of AUC. Results: When applied to the 4 groups of tumor features, the LR model achieved AUCs (95% CI) of 0.57 (0.10), 0.73 (0.07), 0.90 (0.06), and 0.90 (0.06). The SVM model achieved AUCs (95% CI) of 0.56 (0.07), 0.60 (0.06), 0.94 (0.02), and 1.00 (no misclassifications). With the use of spatial-temporal PET features combined with conventional PET/CT measures and clinical parameters, the SVM model achieved very high accuracy (AUC 1.00) and precision (no misclassifications)—results that were significantly better than when conventional PET/CT measures or clinical parameters and demographics alone were used. For groups with many tumor features (groups 3 and 4), the SVM model achieved significantly higher

  8. Modeling Pathologic Response of Esophageal Cancer to Chemoradiation Therapy Using Spatial-Temporal 18F-FDG PET Features, Clinical Parameters, and Demographics

    International Nuclear Information System (INIS)

    Purpose: To construct predictive models using comprehensive tumor features for the evaluation of tumor response to neoadjuvant chemoradiation therapy (CRT) in patients with esophageal cancer. Methods and Materials: This study included 20 patients who underwent trimodality therapy (CRT + surgery) and underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) both before and after CRT. Four groups of tumor features were examined: (1) conventional PET/CT response measures (eg, standardized uptake value [SUV]max, tumor diameter); (2) clinical parameters (eg, TNM stage, histology) and demographics; (3) spatial-temporal PET features, which characterize tumor SUV intensity distribution, spatial patterns, geometry, and associated changes resulting from CRT; and (4) all features combined. An optimal feature set was identified with recursive feature selection and cross-validations. Support vector machine (SVM) and logistic regression (LR) models were constructed for prediction of pathologic tumor response to CRT, cross-validations being used to avoid model overfitting. Prediction accuracy was assessed by area under the receiver operating characteristic curve (AUC), and precision was evaluated by confidence intervals (CIs) of AUC. Results: When applied to the 4 groups of tumor features, the LR model achieved AUCs (95% CI) of 0.57 (0.10), 0.73 (0.07), 0.90 (0.06), and 0.90 (0.06). The SVM model achieved AUCs (95% CI) of 0.56 (0.07), 0.60 (0.06), 0.94 (0.02), and 1.00 (no misclassifications). With the use of spatial-temporal PET features combined with conventional PET/CT measures and clinical parameters, the SVM model achieved very high accuracy (AUC 1.00) and precision (no misclassifications)—results that were significantly better than when conventional PET/CT measures or clinical parameters and demographics alone were used. For groups with many tumor features (groups 3 and 4), the SVM model achieved significantly higher accuracy than

  9. TU-C-12A-09: Modeling Pathologic Response of Locally Advanced Esophageal Cancer to Chemo-Radiotherapy Using Quantitative PET/CT Features, Clinical Parameters and Demographics

    International Nuclear Information System (INIS)

    Purpose: To develop predictive models using quantitative PET/CT features for the evaluation of tumor response to neoadjuvant chemo-radiotherapy (CRT) in patients with locally advanced esophageal cancer. Methods: This study included 20 patients who underwent tri-modality therapy (CRT + surgery) and had 18F-FDG PET/CT scans before initiation of CRT and 4-6 weeks after completion of CRT but prior to surgery. Four groups of tumor features were examined: (1) conventional PET/CT response measures (SUVmax, tumor diameter, etc.); (2) clinical parameters (TNM stage, histology, etc.) and demographics; (3) spatial-temporal PET features, which characterize tumor SUV intensity distribution, spatial patterns, geometry, and associated changes resulting from CRT; and (4) all features combined. An optimal feature set was identified with recursive feature selection and cross-validations. Support vector machine (SVM) and logistic regression (LR) models were constructed for prediction of pathologic tumor response to CRT, using cross-validations to avoid model over-fitting. Prediction accuracy was assessed via area under the receiver operating characteristic curve (AUC), and precision was evaluated via confidence intervals (CIs) of AUC. Results: When applied to the 4 groups of tumor features, the LR model achieved AUCs (95% CI) of 0.57 (0.10), 0.73 (0.07), 0.90 (0.06), and 0.90 (0.06). The SVM model achieved AUCs (95% CI) of 0.56 (0.07), 0.60 (0.06), 0.94 (0.02), and 1.00 (no misclassifications). Using spatial-temporal PET features combined with conventional PET/CT measures and clinical parameters, the SVM model achieved very high accuracy (AUC 1.00) and precision (no misclassifications), significantly better than using conventional PET/CT measures or clinical parameters and demographics alone. For groups with a large number of tumor features (groups 3 and 4), the SVM model achieved significantly higher accuracy than the LR model. Conclusion: The SVM model using all features including

  10. 卵巢卵黄囊瘤30例临床病理分析%Clinical Pathological Analysis of Ovarian Yolk Sac Tumor 30 Cases

    Institute of Scientific and Technical Information of China (English)

    孙秀华; 孙美玲; 王淑芹

    2012-01-01

      Objective To explore the pathological analysis of yolk sac tumor. Methods Select our ovarian yolk sac tumors were cases 30 cases,the clinical data were retrospectively analyzed. Result Typical and mixed types cases are much higher than in other cases pathological types, postoperative follow-up, 10 cases clinicalⅠperiod and 6 cases clinicalⅡperiod patients alive, 2 cases clinicalⅠafter 3 years of death, clinicalⅡperiod after two years in 4 cases were dead, clinicalⅢperiod in 5 patients after one year death in 3, 2 cases died after two years, clinicalⅣperiod after 3 months 2 cases died. Conclusion Many materials and comprehensive observation for correct diagnosis yolk sac tumor the has important function, the histological types and the clinical stages and closely related to the prognosis, clinically by operation with PVB or VAC chemotherapy for treatment.%  目的探讨卵巢卵黄囊瘤的临床病理分析。方法选取我院收治的卵巢卵黄囊瘤病例30例,对其临床资料进行回顾性分析。结果经典型和混合型病例明显高于其他病理类型病例,术后随访,10例临床Ⅰ期和6例临床Ⅱ期患者健在,2例临床Ⅰ期术后3年死亡,临床Ⅱ期4例术后2年死亡,临床Ⅲ期5例术后1年死亡3例,术后2年死亡2例,临床Ⅳ期2例术后3个月均死亡。结论多取材且全面观察对于卵巢卵黄囊瘤的正确诊断具有重要作用,其组织学类型以及临床分期与预后密切相关,临床上多采用手术合并VAC或者PVB化疗方案治疗。

  11. EXPRESSION OF P53 GENE IN ORAL SQUAMOUS CELL CARCINOMA AND ITS RELATION WITH CLINICAL AND PATHOLOGICAL PARAMETERS AND PROGNOSIS OF PATIENTS

    Institute of Scientific and Technical Information of China (English)

    毛驰; 卢勇; 赖钦声; 夏雨和; 杨橙

    1995-01-01

    One hundred and eleven cases of cral squamous cell carcinoma (OSCC) were examined for overexpression of p53 protein by using immunchistochemical technique.Association between p53 protein overexpression and clinical and pathological parameters as well as prognosis of patients were also analyzed. p53 protein overexpression was commonly observed (69.4%) in OSCC and may be used as a marker of carcinogenesis of OSCC.The level of p53 protein overexpression is correlated with the lowet three and five-year survival rate of OSCC.The presence of absence of p53 overexpression was not correlated with sex,age,site of tumor,size of tumor,degree of differentiation,node status,and clinical stage in OSCC.Single factor COX proportinoal hazards regression model analysis indicated that there was no significant association between p53 overexpression and prognosis of OSCC,Multivariable COX model analysis failed to establish effective life function of risk rate function,These showed that all the parameters analyzed in this study as well as p53 overexpression were not significant and effective risk factors of prognosis for patients wich OSCC.

  12. Analysis of C9orf72 repeat expansions in a large series of clinically and pathologically diagnosed cases with atypical parkinsonism.

    Science.gov (United States)

    Schottlaender, Lucia V; Polke, James M; Ling, Helen; MacDoanld, Nicola D; Tucci, Arianna; Nanji, Tina; Pittman, Alan; de Silva, Rohan; Holton, Janice L; Revesz, Tamas; Sweeney, Mary G; Singleton, Andy B; Lees, Andrew J; Bhatia, Kailash P; Houlden, Henry

    2015-02-01

    A GGGGCC repeat expansion in the C9orf72 gene was recently identified as a major cause of familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia. There is suggestion that these expansions may be a rare cause of parkinsonian disorders such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal degeneration (CBD). Screening the C9orf72 gene in 37 patients with features of corticobasal syndrome (CBS) detected an expansion in 3 patients, confirmed by Southern blotting. In a series of 22 patients with clinically diagnosed PSP, we found 1 patient with an intermediate repeat length. We also screened for the C9orf72 expansion in a large series of neuropathologically confirmed samples with MSA (n = 96), PSP (n = 177), and CBD (n = 18). Patients were found with no more than 22 GGGGCC repeats. Although these results still need to be confirmed in a larger cohort of CBS and/or CBD patients, these data suggest that in the presence of a family history and/or motor neuron disease features, patients with CBS or clinical PSP should be screened for the C9orf72 repeat expansion. In addition, we confirm that the C9orf72 expansions are not associated with pathologically confirmed MSA, PSP, or CBD in a large series of cases. PMID:25308964

  13. The Clinical and Pathological Presentation of Thyroid Nodules in Children and the Comparison with Adult Population: Experience of a Single Institution.

    Science.gov (United States)

    Solymosi, Tamas; Lukacs Toth, Gyula; Budai, Laszlo; Gal, Istvan

    2016-01-01

    The clinical and pathological presentation of thyroid nodules among younger and adult patients was compared in an iodine-deficient (ID) region. Data of 3,010 consecutive patients younger than 20 years and 3,010 patients older than 20 years were compared. The proportion of nodular goiters (22.8% versus 39.3%), the ratio of surgically treated nodules (33.2% versus 15.2%), and the proportion of malignant nodules (4.3% versus 2.1%) among diseased patients differed significantly between the two groups (younger versus adult). Nine papillary and 1 medullary carcinoma were found among children, while 15 papillary, 2 follicular, 1 insular, 1 anaplastic, and 1 medullary carcinomas occurred among adults. The ratio of follicular adenoma to hyperplastic nodules (3 : 1 to 1 : 1.67), the proportion of follicular variant (77.8% versus 26.7%), T4 tumors (77.8% versus 33.3%), and tumors with lymph node metastasis (88.9% versus 66.7%) were significantly higher among younger papillary carcinoma patients. No malignancies occurred among spongiform and central type cysts. Similarly to iodine-sufficient regions, more nodules are malignant and carcinomas have a clinically more aggressive presentation in children in comparison with adult patients in ID. Taking the significantly greater proportion of adenomas and the lack of follicular carcinoma into account, a conservative approach has to be considered in follicular tumors among children. PMID:27087807

  14. The Clinical and Pathological Presentation of Thyroid Nodules in Children and the Comparison with Adult Population: Experience of a Single Institution

    Directory of Open Access Journals (Sweden)

    Tamas Solymosi

    2016-01-01

    Full Text Available The clinical and pathological presentation of thyroid nodules among younger and adult patients was compared in an iodine-deficient (ID region. Data of 3,010 consecutive patients younger than 20 years and 3,010 patients older than 20 years were compared. The proportion of nodular goiters (22.8% versus 39.3%, the ratio of surgically treated nodules (33.2% versus 15.2%, and the proportion of malignant nodules (4.3% versus 2.1% among diseased patients differed significantly between the two groups (younger versus adult. Nine papillary and 1 medullary carcinoma were found among children, while 15 papillary, 2 follicular, 1 insular, 1 anaplastic, and 1 medullary carcinomas occurred among adults. The ratio of follicular adenoma to hyperplastic nodules (3 : 1 to 1 : 1.67, the proportion of follicular variant (77.8% versus 26.7%, T4 tumors (77.8% versus 33.3%, and tumors with lymph node metastasis (88.9% versus 66.7% were significantly higher among younger papillary carcinoma patients. No malignancies occurred among spongiform and central type cysts. Similarly to iodine-sufficient regions, more nodules are malignant and carcinomas have a clinically more aggressive presentation in children in comparison with adult patients in ID. Taking the significantly greater proportion of adenomas and the lack of follicular carcinoma into account, a conservative approach has to be considered in follicular tumors among children.

  15. Clinical and pathologic considerations of the qualitative and quantitative aspects of lupus nephritogenic autoantibodies: A comprehensive review.

    Science.gov (United States)

    Gatto, Mariele; Iaccarino, Luca; Ghirardello, Anna; Punzi, Leonardo; Doria, Andrea

    2016-05-01

    Autoantibodies are key mediators in determining the clinical manifestations of systemic lupus erythematosus (SLE). The mechanisms by which antibodies may be harmful to self tissues encompass complement mediated inflammation, cell apoptosis and immune-complexes mediated damage, however the precise cooperation of antibodies in SLE have not been unravelled so far. Lupus nephritis (LN) is a protean feature of SLE resulting in wide variety of symptoms including asymptomatic proteinuria, mild renal disease until end-stage renal failure which are triggered by complex autoantibody interactions. Novel clues concerning development and self-maintenance of LN have come to light in recent times, pointing straight to a multistep inflammatory process which is incited by anti-chromatin antibodies, the best known being anti-DNA and anti-nucleosome antibodies, culminating in a self-maintaining inflammatory loop with spreading of glomerular inflammation. In the maintenance of the inflammatory process pro-inflammatory antibodies are involved, among which anti-C1q are thought to play a major role, whereas hindrance of the nephritic process could be actively mediated by protective autoantibodies. Despite being so relevant in occurrence of LN, nor anti-chromatin neither anti-C1q antibodies have been precisely characterized in terms of origin, antigen specificity and mechanisms of action. Moreover, novel autoantibodies are emerging in LN which can modify disease course, whereas the pathogenic value of a myriad of cross-reactive antibodies has been progressively challenged. The aim of this review is to give a comprehensive view of known and emerging autoantibody reactivities involved in renal inflammation and damage going over their origin, mechanisms of action and interactions in determining LN course. PMID:26879422

  16. Phyllodes tumor of the breast: a clinic-pathologic study of 77 cases in a Hispanic cohort

    Directory of Open Access Journals (Sweden)

    Carlos Andres Ossa Gomez

    2015-10-01

    Full Text Available Introduction:Breast Phyllodes tumors are rare breast tumors present in less than 1% of new cases of breast cancer, usually occurring among middle-aged women (40-50 yrs.Objective:This study shows diagnostic experience, surgical management and follows up of patients with this disease during a period of ten years in a oncology referral center.Methods:Retrospectively, breast cancer registries at the institution were reviewed, identifying 77 patients with Phyllodes tumors between 2002 and 2012, who had been operated on at the Instituto de Cancerología - Clínica Las Américas, in Medellín (Colombia. Clinical and histopathological data belonging to these cases was captured and analyzed and descriptive statistics were used.Results:The follow up median was 22.5 months (IQR: 10.5-60.0, average age was 47.2 yrs (SD: 12.4, mean tumor size was 3.6 cm (SD: 4.6, 88.3% of the patients (68 cases presented negative margins and none of them received adjuvant chemotherapy. Of the patients with Phyllodes tumors; 33.8% had benign, 31.2% had borderline and 35.0% had malignant tumor. Disease-free survival was 85.8% and overall survival was 94.5%.Discussion:Reported data in this article is in accordance with what has been reported in worldwide literature. In our cohort even the high mean size of the tumors, the risk of local relapse and metastatic disease is low than previously reported in literature. Trials with longer follow up and molecular trials in Phyllodes tumors are necessary to understand the behavior of these tumors in Hispanics population.

  17. Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Tse HN

    2014-08-01

    Full Text Available Hoi Nam Tse, Cee Zhung Steven TsengMedical and Geriatric Department, Kwong Wah Hospital, Hong Kong Special Administrative RegionAbstract: Chronic obstructive pulmonary disease (COPD is a common and morbid disease characterized by high oxidative stress. Its pathogenesis is complex, and involves excessive oxidative stress (redox imbalance, protease/antiprotease imbalance, inflammation, apoptosis, and autoimmunity. Among these, oxidative stress has a pivotal role in the pathogenesis of COPD by initiating and mediating various redox-sensitive signal transduction pathways and gene expression. The protective physiological mechanisms of the redox balance in the human body, their role in the pathogenesis of COPD, and the clinical correlation between oxidative stress and COPD are reviewed in this paper. N-acetylcysteine (NAC is a mucolytic agent with both antioxidant and anti-inflammatory properties. This paper also reviews the use of NAC in patients with COPD, especially the dose-dependent properties of NAC, eg, its effects on lung function and the exacerbation rate in patients with the disease. Earlier data from BRONCUS (the Bronchitis Randomized on NAC Cost-Utility Study did not suggest that NAC was beneficial in patients with COPD, only indicating that it reduced exacerbation in an "inhaled steroid-naïve" subgroup. With regard to the dose-dependent properties of NAC, two recent randomized controlled Chinese trials suggested that high-dose NAC (1,200 mg daily can reduce exacerbations in patients with COPD, especially in those with an earlier (moderately severe stage of disease, and also in those who are at high risk of exacerbations. However, there was no significant effect on symptoms or quality of life in patients receiving NAC. Further studies are warranted to investigate the effect of NAC at higher doses in non-Chinese patients with COPD.Keywords: N-acetylcysteine, antioxidant, anti-inflammatory, chronic obstructive pulmonary disease

  18. [F-18]Fluorodeoxyglucose positron emission tomography can predict pathological tumor stage and proliferative activity determined by Ki-67 in clinical stage IA lung adenocarcinomas

    International Nuclear Information System (INIS)

    The objective of this study was to predict a malignant grade of lung cancer by fluorodeoxyglucose positron emission tomography (FDG-PET) scanning, we investigated the correlation between FDG uptake and pathological tumor stage, proliferative activities determined by Ki-67 and cyclin D1, and an alteration of p53, in clinical stage (c-stage) IA lung adenocarcinomas. FDG-PET was performed for 71 patients with c-stage IA lung adenocarcinomas. FDG uptake was measured by a contrast ratio (CR) between the tumor and contralateral lung. Ki-67, cyclin D1 and p53 staining scores were examined by immunohistochemistry. The lesions with ground-glass opacity were found in 26 patients, and solid lesions in 45 by computed tomography. The pathological tumor stages (p-stage) were stage IA in 59 and more advanced stages in 12. The latter had significantly higher CR value than the former (P<0.001). Patients with CR≥0.55 could be predicted to be at advanced tumor stages, with a sensitivity of 0.83 and a specificity of 0.82. The CR and staining scores of Ki-67 were significantly correlated with each other (P<0.0001), and both the values were significantly higher in advanced tumor stages than in p-stage IA, and were also significantly higher in tumors with intratumoral lymphatic, vascular and pleural involvements than in those without such features (P<0.05-0.0001). In c-stage IA lung adenocarcinomas, the FDG uptake can predict p-stage and tumor proliferative activity determined by Ki-67. For c-stage IA lung adenocarcinomas showing CR≥0.55, mediastinoscopy or neoadjuvant chemotherapy is indicated. (author)

  19. Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina: a clinic and pathological correlation with special consideration on the central nervous system

    Directory of Open Access Journals (Sweden)

    Elvio E. Ríos

    2012-01-01

    Full Text Available Ipomoea carnea subsp. fistulosa, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these hydrolases. There is neuronal vacuolation, endocrine dysfunction, cardiovascular and gastrointestinal injury, and immune disorders. Clinical signs and pathology of the experimental poisoning of goats by Ipomoea carnea in Argentina are here described. Five goats received fresh leaves and stems of Ipomoea. At the beginning, the goats did not consume the plant, but later, it was preferred over any other forage. High dose induced rapid intoxication, whereas with low doses, the course of the toxicosis was more protracted. The goats were euthanized when they were recumbent. Cerebrum, cerebellum, medulla oblongata, pons and colliculi, were routinely processed for histology. In nine days, the following clinical signs developed: abnormal fascies, dilated nostrils and abnormal postures of the head, cephalic tremors and nystagmus, difficulty in standing. Subsequently, the goats had a tendency to fall, always to the left, with spastic convulsions. There was lack in coordination of voluntary movements due to Purkinje and deep nuclei neurons damage. The cochlear reflex originated hyperreflexia, abnormal posture, head movements and tremors. The withdrawal reflex produced flexor muscles hypersensitivity at the four legs, later depression and stupor. Abnormal responses to sounds were related to collicular lesions. Thalamic damage altered the withdrawal reflex, showing incomplete reaction. The observed cervical hair bristling was attributed to a thalamic regulated nociceptive response. Depression may be associated with agonists of lysergic acid contained in Ipomoea. These clinical signs were correlated with lesions in different parts of the CNS.

  20. PRIMARY SMALL INTESTINAL MALIGNANCY - A CLINIC O - PATHOLOGICAL STUD Y, ITS COMPARIS I ON WITH PRIMARY GASTROINTESTINAL MALIGNANCY AND EARLIER STUDIES

    Directory of Open Access Journals (Sweden)

    Rajesh Kumar

    2015-06-01

    Full Text Available OBJECTIVES: The aim of the study is to determine the clinico - pathological features of primary small intestinal malignant tumors and to compare with primary gastrointestinal malignancies and prev ious studies. MATERIALS AND METHOD S: 11 patients with primary small intestine malignant tumors diagnosed over a 5 year period were studied clinically and histopathologically, they were classified using the WHO classification and compared with 300 primary g astrointestinal tumors and the previous studies. RESULTS: 11 patients (3.6% were small intestine malignancies arising out of 300 primary gastrointestinal malignancies, with a male to female ratio of 1:1.2. Majority were females, majority were non vegetarians and most of the males were alcoholics and smokers. The youngest patient affected is 34 years old and the oldest patient is 67 years old with mean age of 52.17 and median age of 53 years. Tumor more common in the fifth to seventh decade of life. Altered bowel habits, abdominal discomfort was the most common clinical presentatio ns followed by abdominal pain and vomiting in few cases. Duodenum was commonest site (72.2% and few cases with equal proportion occurred in jejunum and ileum (9.09%. The commonest gross presentation was polypoidal growth (63.6% and the rest of the tumor s were ulcerative type. Adenocarcinoma was the most common histological type (81.8% and 9% were Carcinoid and Gastrointestinal stromal tumor. CONCLUSION: Primary small intestinal malignancy constitute about 3.6% of allgastrointestinal malignancies, female s commonly affected (1:1.2 and more common in alcoholics and non - vegetarians. Altered bowel habits, abdominal discomfort was the most common clinical presentations, Duodenum was commonest site (72.2%, The commonest gross presentation was polypoidal growt h (63.6%, Adenocarcinoma was the most common histological type (81.8%

  1. Correlation of clinical and pathologic features with outcome in patients with ductal carcinoma in situ of the breast treated with breast-conserving surgery and radiotherapy

    International Nuclear Information System (INIS)

    Purpose: Although breast-conserving surgery followed by radiotherapy (RT) has become a standard treatment option for patients with ductal carcinoma in situ of the breast, risk factors for ipsilateral breast tumor recurrence (IBTR) in these patients remain an active area of investigation. The purpose of this study was to evaluate the impact of clinical and pathologic features on long-term outcome in a cohort of DCIS patients treated with breast-conserving surgery plus RT. Methods and Materials: Between 1973 and 1998, 230 patients with DCIS were treated with breast-conserving surgery plus RT at our institution. All patients were treated by local excision followed by RT to the breast to a total median tumor bed dose of 64 Gy. Adjuvant hormonal therapy was used in only 20 patients (9%). All available clinical, pathologic, and outcome data, including ipsilateral and contralateral events, were entered into a computerized database. The clinical and pathologic variables evaluated included detection method, mammographic appearance, age, family history, histologic subtype, presence of necrosis, nuclear grade, final margin status, and use of adjuvant hormonal therapy. Results: As of December 15, 2000, with a median follow-up of 8.2 years, 17 patients had developed a recurrence in the ipsilateral breast, resulting in a 5- and 10-year IBTR rate of 5% and 13%, respectively. Contralateral breast cancer developed in 8 patients, resulting in a 10-year contralateral recurrence rate of 5%. Patient age, family history, histologic subtype, margin status, and tumor grade were not significantly associated with recurrence on univariate analysis. A significantly higher rate of local relapse was observed in patients with the presence of necrosis. The 10-year relapse rate was 22% in 88 patients with necrosis compared with 7% in 142 patients without necrosis (p <0.01). In multivariate analysis, the presence of necrosis remained a significant predictor of local relapse. No breast relapses

  2. Ductal carcinoma in situ detected in the mammographic era: an analysis of clinical, pathologic, and treatment-related factors affecting outcome with breast-conserving therapy

    International Nuclear Information System (INIS)

    Purpose: We reviewed our institution's experience treating predominantly mammographically detected ductal carcinoma in situ (DCIS) with breast-conserving therapy (BCT) to determine if any clinical, pathologic, or treatment-related factors affected outcome. Methods and Materials: From January 2, 1980 to January 6, 1992, 107 breasts in 105 patients were treated with BCT at William Beaumont Hospital, Royal Oak, MI. All patients underwent at least an excisional biopsy and 70 patients (65%) were reexcised. All patients received whole-breast irradiation to a median dose of 50.4 Gy (range 43.1 to 56.0 Gy). Ninety-nine patients (93%) received a supplemental boost to the tumor bed for a median total dose of 60.4 Gy (range 59.1 to 71.8 Gy) using either photons (2 patients), electrons (69 patients), or an interstitial implant (28 patients). Results: With a median follow-up of 78 months, 10 patients have failed in the treated breast for a 5- and 10-year actuarial local control rate of 91.2 and 89.8%, respectively. Thirteen percent of the population have been followed for 10 years or more. Three recurrences were pure DCIS, and seven were invasive. All patients were salvaged with mastectomy. Nine patients remain without evidence of disease a median of 30.6 months after surgery. One patient failed distantly 36 months after local recurrence for an ultimate cause specific survival of 99%. Potential clinical (age, mammographic findings, method of detection, etc.), pathologic (nuclear grade, margins, etc.), and treatment-related factors (dose, boost technique, reexcision status, etc.) affecting outcome were analyzed. No variable was found to be associated with an ipsilateral breast tumor recurrence. However, when only recurrences that occurred within or immediately adjacent to the lumpectomy cavity were analyzed, both margin status and the extent of cancerization of lobules (COL) near the surgical margin were associated with the development of a local recurrence. Conclusions

  3. Systematic review of 20 clinical pathological conference articles on tuberculosis%20篇结核病临床病理讨论系统回顾分析

    Institute of Scientific and Technical Information of China (English)

    何权瀛; 邹黎

    2005-01-01

    目的探讨结核病误诊的原因.方法手工检索近20年发表在中华结核和呼吸杂志等五种中华级杂志上的20篇有关结核病误诊的临床病理讨论(clinical pathological conference, CPC)文章,并逐一登记患者的临床特征、最后病理诊断、应吸取的教训等.结果 20例结核病中急性粟粒性结核13例,占65.0%;大量使用糖皮质激素引起结核活动、播散共8例,占40.0%.结论临床医生必须高度重视结核病的诊断,以期减少结核病漏诊.

  4. A CLINIC O PATHOLOGICAL STUDY OF PRIMARY GASTRIC MALIGNANCY AND ITS COMPARISON WITH PRIMARY GASTROINTESTINAL MALIGNANCY IN TERT I ARY CARE HOSPITAL IN SOUTH INDIA

    Directory of Open Access Journals (Sweden)

    Rajesh Kumar

    2015-04-01

    Full Text Available OBJECTIVES : The aim of the study is to determine the clinico - pathological features of primary gastric tumors and to compare with primary gastrointestinal malignancies. MATERIALS AND METHODS: 152 patients with primary Gastric tumors diagnosed over a 5 year period studied clinically and histopathologically they were classified using the Fletcher classification and compared with 300 primary gastrointestinal tumors . DIAGNOSI S : RESULT: 152 patients (50.6% were Gastric malignancies arising out of 300 primary gastrointestinal malignancies, with a female to male ratio of 2.4 : 1. Majority was males, majority were non vegetarians and most of the males were alcoholics and smokers. The mean age of the male patients was 46 years with age varying from 19 – 83 years, while for females, the mean age was 48 years, ranging from 40 - 70 years. Abdomen pain was the most common presenting symptom (70%, and the most common primary site was stomac h (50 , 6.2%, followed by large intestine (16%. Most of the gastric tumors were ulceroproliferative lesion and adenocarcinoma . CONCLUSION: Primary gastric malignancy constitute about 50.6% of all gastrointestinal malignancies males commonly affected (2.4:1 and more common in alcoholics and non vegetatrians. Abdomen pain was the common presenting symptom ulceroprolifeative type is common gross presentation (67.7%, adenocarcinoma (9 , 97.3% was the commonly tumor, pylorus and antrum was common site ( 57.9%. KEYWORDS: Primary gastric malignancy .

  5. Image-Guided Cryoablation of the Spine in a Swine Model: Clinical, Radiological, and Pathological Findings with Light and Electron Microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Ricardo Miguel Costa de, E-mail: ricardomcfreitas@gmail.com; Andrade, Celi Santos, E-mail: celis.andrade@hotmail.com; Caldas, José Guilherme Mendes Pereira, E-mail: jgmpcaldas@uol.com.br [Faculdade de Medicina da Universidade de São Paulo, Department of Radiology, Interventional Radiology Unit of the Instituto de Radiologia (Brazil); Tsunemi, Miriam Harumi, E-mail: miharumi@gmail.com [Universidade Estadual Paulista Júlio de Mesquita Filho, Department of Biostatistics, Biosciences Institute (Brazil); Ferreira, Lorraine Braga, E-mail: lorraine.braga@gmail.com; Arana-Chavez, Victor Elias, E-mail: vearana@usp.br [Faculdade de Odontologia da Universidade de São Paulo, Department of Oral Pathology (Brazil); Cury, Patrícia Maluf, E-mail: pmcury@hotmail.com [Faculdade de Medicina de São José do Rio Preto, Department of Pathology and Forensic Medicine (Brazil)

    2015-10-15

    PurposeThis study was designed to present the feasibility of an in vivo image-guided percutaneous cryoablation of the porcine vertebral body.MethodsThe institutional animal care committee approved this study. Cone-beam computed tomography (CBCT)-guided vertebral cryoablations (n = 22) were performed in eight pigs with short, 2-min, single or double-freezing protocols. Protective measures to nerves included dioxide carbon (CO{sub 2}) epidural injections and spinal canal temperature monitoring. Clinical, radiological, and pathological data with light (n = 20) or transmission electron (n = 2) microscopic analyses were evaluated after 6 days of clinical follow-up and euthanasia.ResultsCBCT/fluoroscopic-guided transpedicular vertebral body cryoprobe positioning and CO{sub 2} epidural injection were successful in all procedures. No major complications were observed in seven animals (87.5 %, n = 8). A minor complication was observed in one pig (12.5 %, n = 1). Logistic regression model analysis showed the cryoprobe-spinal canal (Cp-Sc) distance as the most efficient parameter to categorize spinal canal temperatures lower than 19 °C (p < 0.004), with a significant Pearson’s correlation test (p < 0.041) between the Cp-Sc distance and the lowest spinal canal temperatures. Ablation zones encompassed pedicles and the posterior wall of the vertebral bodies with an inflammatory rim, although no inflammatory infiltrate was depicted in the surrounding neural structures at light microscopy. Ultrastructural analyses evidenced myelin sheath disruption in some large nerve fibers, although neurological deficits were not observed.ConclusionsCBCT-guided vertebral cryoablation of the porcine spine is feasible under a combination of a short freezing protocol and protective measures to the surrounding nerves. Ultrastructural analyses may be helpful assess the early modifications of the nerve fibers.

  6. Image-Guided Cryoablation of the Spine in a Swine Model: Clinical, Radiological, and Pathological Findings with Light and Electron Microscopy

    International Nuclear Information System (INIS)

    PurposeThis study was designed to present the feasibility of an in vivo image-guided percutaneous cryoablation of the porcine vertebral body.MethodsThe institutional animal care committee approved this study. Cone-beam computed tomography (CBCT)-guided vertebral cryoablations (n = 22) were performed in eight pigs with short, 2-min, single or double-freezing protocols. Protective measures to nerves included dioxide carbon (CO2) epidural injections and spinal canal temperature monitoring. Clinical, radiological, and pathological data with light (n = 20) or transmission electron (n = 2) microscopic analyses were evaluated after 6 days of clinical follow-up and euthanasia.ResultsCBCT/fluoroscopic-guided transpedicular vertebral body cryoprobe positioning and CO2 epidural injection were successful in all procedures. No major complications were observed in seven animals (87.5 %, n = 8). A minor complication was observed in one pig (12.5 %, n = 1). Logistic regression model analysis showed the cryoprobe-spinal canal (Cp-Sc) distance as the most efficient parameter to categorize spinal canal temperatures lower than 19 °C (p < 0.004), with a significant Pearson’s correlation test (p < 0.041) between the Cp-Sc distance and the lowest spinal canal temperatures. Ablation zones encompassed pedicles and the posterior wall of the vertebral bodies with an inflammatory rim, although no inflammatory infiltrate was depicted in the surrounding neural structures at light microscopy. Ultrastructural analyses evidenced myelin sheath disruption in some large nerve fibers, although neurological deficits were not observed.ConclusionsCBCT-guided vertebral cryoablation of the porcine spine is feasible under a combination of a short freezing protocol and protective measures to the surrounding nerves. Ultrastructural analyses may be helpful assess the early modifications of the nerve fibers

  7. Pathology of tropical appendicitis.

    OpenAIRE

    S. C. Gupta; A. K. Gupta; Keswani, N. K.; Singh, P. A.; Tripathi, A.K.; Krishna, V.

    1989-01-01

    Over the past 25 years, 2921 appendicectomies were performed at this hospital. All were subjected to routine histopathological examination. In 95% of cases, histopathological examination did not add any further information but in 153 (5%) cases, clinically important pathological findings were detected for the first time. Seventy (2.3%) specimens showed typical evidence of tuberculosis. Parasitic infestation was detected in 75 (2.5%), including enterobiasis (1.4%), amoebiasis (0.5%), ascariasi...

  8. Pathological gambling.

    Science.gov (United States)

    Hollander, E; Buchalter, A J; DeCaria, C M

    2000-09-01

    With increasing access to gambling facilities through casinos, the Internet, and other venues, PG is a rapidly emerging mental health concern. This impulse-control disorder tends to be comorbid with a wide range of other disorders and is reportedly associated with a high rate of suicide. For most gamblers, gambling is a form of entertainment, but for many individuals, the activity leads to far-reaching disruption of family and work. The personal and societal financial ramifications are severe, and many individuals with PG end up in the criminal justice system. An understanding of the neurobiology of PG is beginning to surface. 5-HT is linked to behavioral initiation and disinhibition, which are important in the onset of the gambling cycle and the difficulty in ceasing the behavior. Norepinephrine is associated with the arousal and risk taking in patients with PG. Dopamine is linked to positive and negative reward, the addictive component of this disorder. Effective treatment strategies for pathological gamblers are emerging. Potentially useful pharmacologic agents include SRIs (clomipramine and fluvoxamine), mood stabilizers for pathological gamblers with comorbid bipolar disorders (lithium), and naltrexone. Cognitive-behavioral psychotherapies offer promising results in the treatment of patients with this disorder. To devise prevention and early-intervention programs, research is needed to identify specific features of the individuals at risk for gambling problems. Education targeting vulnerable youth that show early signs of gambling behavior may be worthwhile and should be investigated further. Funding is necessary to support these endeavors, so perhaps a portion of tax revenues generated from the gambling industry should go toward specialized treatment facilities, educational efforts, and research into the neurobiology and treatment of PG. PMID:10986732

  9. Tumor markers and clinical pathological diagnosis of lung cancer%肺癌的肿瘤标志物与临床病理诊断分析

    Institute of Scientific and Technical Information of China (English)

    吕静; 李冰; 吕艳萍

    2015-01-01

    Objective: To explore the effect of tumor markers and clinical pathological diagnosis of lung cancer.Methods:Selected in our hospital in December 2012 and 2015 March were 148 cases accept antitumor therapy were treated with CY-FRA21-1, CEA and NSE of serum tumor markers of patients tested randomly were divided into the experimental group and the control group, the experimental group 80 cases in the control group (n = 68). The level of tumor markers in the two groups was analyzed.Results: In the control group and experimental group lung cancer patients' age, gender, case classification and difference no statistical significance (P>0.05). Patients in the experimental group 3 in serum tumor signs were significantly higher than those in the control group, the difference was statistically significant (P0.05),实验组患者3中血清肿瘤标志物水平明显高于对照组,差异有统计学意义(P<0.05).结论 肺癌患者肿瘤标志物升高相较于对照组临床分期晚,对照组患者肿瘤标志物3种血清水平明显低于实验组,说明肿瘤标志物可作为临床病例评估肺癌患者,准确率较高,是患者治疗肺癌的重要指示.

  10. Intermittent Auscultation in Labor: Could It Be Missing Many Pathological (Late) Fetal Heart Rate Decelerations? Analytical Review and Rationale for Improvement Supported by Clinical Cases.

    Science.gov (United States)

    Sholapurkar, Shashikant L

    2015-12-01

    Intermittent auscultation (IA) of fetal heart rate (FHR) is recommended/preferred in low risk labors. Its usage even in developed countries is poised to increase because of perceived benefit of reduction in operative intervention and some disillusionment with the cardiotocography (CTG). Many national guidelines have stipulated regimes (frequency/timing) of IA based on level IV evidence. These tend to get faithfully and exactingly followed. It was observed that deliveries of many unexpectedly asphyxiated infants occurred despite rigorously performed and documented IA compliant with the guidelines. This triggered a reappraisal of the robustness of IA leading to this focused review supplemented by two anonymized cases. It concludes that the current methodology of IA may be flawed in that it poses a risk of missing many or most late (pathological) FHR decelerations, one of the foremost goals of IA. This is because many late decelerations reach their nadir before the end of the contraction. Thus the currently recommended auscultation of FHR for 60 seconds after the contraction by all national guidelines seemed to encompass their "recovery" phase and appeared to be misinterpreted as normal FHR or even as a reassuring accelerative pattern in the clinical practice. A recent recommendation of recording of the FHR as a single figure (rather than a range) does not remedy this anomaly and seems even less informative. It would be better to auscultate FHR before and after the contractions (or contraction to contraction) and take the FHR just before the contraction as the baseline FHR and interpret the FHR after contraction in the context of this baseline. This relatively simple improvement would detect most late FHR decelerations thus ameliorating the risk and significantly enhancing the patient safety. PMID:26566404

  11. Prognostic value of stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death

    International Nuclear Information System (INIS)

    The purpose of the present study was to evaluate the prognostic value of POSTN expression following prostatectomy. Periostin (POSTN) expression in prostate cancer (PCa) and in normal specimens was evaluated in 90 patients by an immuno-reactive score(IRS) based on the intensity of immunostaining and on the quantity of stained cells. The t-test was applied to compare IRS values in cancer specimens to values in normal specimens. Pearson’s test was used to correlate POSTN expression to clinical pathologic features. PSA progression-free and survival curves were constructed by the Kaplan–Meier method and compared using the log-rank test. Multi-parametric models were constructed according to the Cox technique adding all the covariates predicting for either PSA progression or death into the models after univariate analysis. Both stromal and epithelial POSTN expression were significantly increased in tumor tissues. In particular, we found stromal expression to be significantly higher than epithelial expression as compared to normal tissues (p<0.000 and p=0.001).A significant correlation between POSTN epithelial expression and extra-prostatic extension was found (p=0.03). While high stromal expression was significantly associated with shorter survival (p=0.008), a low epithelial score significantly correlated with shorter PSA-free survival (p=0.04), suggesting that POSTN plays an apparently opposing biological role depending on its compartmentalization.Regardless of the mechanism that is involved, patients showing both high stromal and low epithelial expression made up a subgroup with a very bleak prognosis. Although requiring further validation through larger studies, our findings show that POSTN might represent a novel prognostic marker for PCa

  12. Tumour regression grading after chemoradiotherapy for locally advanced rectal cancer: A near pathologic complete response does not translate into good clinical outcome

    International Nuclear Information System (INIS)

    Background: After preoperative chemoradiotherapy (CRT) for rectal cancer, clinically undetectable residual tumour deposits or pathologic lymph nodes may remain in the mesorectum. Aim: The aim of this study was to report histopathological effects of CRT and factors affecting outcome in a uniformly treated series of locally advanced rectal cancer (LARC) patients. Methods: Between 2004 and 2008, 107 patients with cT3 (threatening the mesorectal fascia or <5 cm from the anal verge), cT4 or cN2 rectal cancer were treated with preoperative CRT (25 × 2 Gy with capecitabine) and TME 6–8 weeks later. Central histopathological review followed. Tumour regression grade (TRG) was scored in pCR, near-pCR, response and no response. Cox regression was performed to identify prognosticators. Results: The 3-year distant metastasis-free interval, disease-free rate and overall survival rate were 82%, 73% and 87% (median 44 months follow-up). TRG consisted of 20% pCR, 11% near-pCR, 55% response and 14% no response. 6/21 pCR patients harboured nodal metastases. 5/12 near-pCR had ypT3 disease, while 6 harboured node metastases. 5/12 near-PCR patients developed distant metastases. ypN and TRG were powerful outcome discriminators. Conclusion: The high number of near-pCR with ypT3 or ypN1/2 and their poor outcome demonstrates that “watch-and-wait” in LARC patients should be applied with care

  13. 基底细胞癌29例临床病理分析%Clinical and pathological analysis of 29 cases of basal cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    周红; 陈敏慧

    2012-01-01

    Objective: To study the clinical features of skin basal cell carcinoma. Methods: Data of 29 cases of basal cell carcinoma was analyzed. Results: The ratio of male and female in these patients was 1: 1. 23. Age ranged from 36 to 81, patients over 50 - years - old of 24 patients was 82.76%. The most common type of nodules was solid (16 cases 55. 17% ). Conclusion: This disease developed more in old person with long term sun exposure.Pathological examination in the correct diagnosis, treatment and prognosis plays an important role.%目的:探讨皮肤基底细胞癌(basal cell carcinoma.BCC)临床病理特点及诱发因素,提高对该病的诊断水平.方法:对29例基底细胞癌患者的临床病理资料进行综合分析.结果:本组患者中男性13例,女性16例,男女比例1:1.23,年龄36 -81岁,其中≥50岁24例(82.76%),农民居多,以结节型(实性)最多见(16例,55.17%).结论:基底细胞癌的发病以中老年为主,好发于头面部等暴晒部位,基底细胞癌的发生与慢性长期日光照射密切相关,病理检查对该病的正确诊断、治疗及预后判断起着重要作用.

  14. Cell Line Derived Multi-Gene Predictor of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A Validation Study on US Oncology 02-103 Clinical Trial

    Directory of Open Access Journals (Sweden)

    Shen Kui

    2012-11-01

    Full Text Available Abstract Background The purpose of this study is to assess the predictive accuracy of a multi-gene predictor of response to docetaxel, 5-fluorouracil, epirubicin and cyclophosphamide combination chemotherapy on gene expression data from patients who received these drugs as neoadjuvant treatment. Methods Tumor samples were obtained from patients with stage II-III breast cancer before starting neoadjuvant chemotherapy with four cycles of 5-fluorouracil/epirubicin/cyclophosphamide (FEC followed by four cycles of docetaxel/capecitabine (TX on US Oncology clinical trial 02-103. Most patients with HER-2-positive cancer also received trastuzumab (H. The chemotherapy predictor (TFEC-MGP was developed from publicly available gene expression data of 42 breast cancer cell-lines with corresponding in vitro chemotherapy sensitivity results for the four chemotherapy drugs. No predictor was developed for treatment with trastuzumab. The predictive performance of TFEC-MGP in distinguishing cases with pathologic complete response from those with residual disease was evaluated for the FEC/TX and FEC/TX plus H group separately. The area under the receiver-operating characteristic curve (AU-ROC was used as the metric of predictive performance. Genomic predictions were performed blinded to clinical outcome. Results The AU-ROC was 0.70 (95% CI: 0.57-0.82 for the FEC/TX group (n=66 and 0.43 (95% CI: 0.20-0.66 for the FEC/TX plus H group (n=25. Among the patients treated with FEC/TX, the AU-ROC was 0.69 (95% CI: 0.52-0.86 for estrogen receptor (ER-negative (n=28 and it was 0.59 (95% CI: 0.36-0.82 for ER-positive cancers (n=37. ER status was not reported for one patient. Conclusions Our results indicate that the cell line derived 291-probeset genomic predictor of response to FEC/TX combination chemotherapy shows good performance in a blinded validation study, particularly in ER-negative patients.

  15. Mesotelioma maligno: Experiencia clínico-patológica de 247 casos Malignant mesothelioma: Clinical and pathological features from 247 cases

    Directory of Open Access Journals (Sweden)

    RAÚL BARRERA R

    2010-09-01

    Full Text Available Objetivo: Este estudio describe la frecuencia, características patológicas, ocupación y exposición a asbesto en una cohorte grande de casos de mesotelioma maligno (MM admitidos en el Instituto Nacional de Enfermedades Respiratorias (INER, en México. Método: Se llevó a cabo un estudio retrospectivo y transversal en los registros médicos de pacientes diagnosticados con MM entre los años 1991-2007. Resultados: De los 247pacientes, 184 fueron hombres y 63 fueron mujeres con un promedio de edad de 51 y 60 años. Disnea y dolor torácico fueron los principales síntomas observados. Exposición a fibras de asbesto fue referida sólo en 34% de los casos, aunque una exposición directa sólo puedo ser documentada en cinco de ellos. Las características clínicas de los pacientes con MM fueron similares en aquellos con y sin exposición a asbesto reconocida. Conclusión: Aunque se observa una tendencia creciente en el número de casos con MM, en muchos de ellos no fue posible establecer una fuente de exposición a asbesto como la causa de contaminación para el desarrollo de la enfermedad.Objective: This study describes the frequency, occupational, clinical, and pathological features in a large cohort of cases of Malignant Mesothelioma (MM from the National Institute of Respiratory Diseases (INER, in México. Methods: A retrospective and transversal study was carried out in medical records of patients diagnosed with MM between the years 1991 to 2007. Results: Of the 247 patients, 184 were male and 63 were female with an average age of 51-60 years. Dyspnea and chest pain were the presenting symptoms in most of the patients. Exposure to asbestos was referred only in 34% of cases but direct exposition only was documented in five of them. Clinical features of MM patients were similar in asbestos related and non-asbestos related malignant mesothelioma. Conclusion: Although a growing tendency is observed in, the number of cases with MM, in many of them

  16. Clinical pathological analysis of children with medulloblastoma%儿童髓母细胞瘤临床病理分析

    Institute of Scientific and Technical Information of China (English)

    程向华; 陈建华; 陈奎生

    2014-01-01

    Objectives To explore the pathological characteristics, treatment and prognosis of medulloblastoma (MB) in children. Methods Pathological characteristics, treatment outcomes and other clinical data were retrospectively analyzed in 60 children with MB. Results The MB in all 60 children were high-grade tumor. The pathological type was mainly classic (45 cases, 75.00%) and other subtypes were seen in 15 cases (25.00%). Forty-eight (80.00%) children had total resection by micro-surgery, 9 children (15.00%) subtotal resection, and 3 children (5.00%) partial resection. Twenty-seven children were treated by radiotherapy after surgery, 6 children were treated by chemotherapy after surgery, and 5 children were treated with radiotherapy combined chemotherapy after surgery. Thirty-eight cases were followed up. The 2-year survival and disease-free survival rates were 63.16%and 55.26%. The 5-year survival and disease-free survival rates were 26.32%and 18.42%. The children with des-moplastic/nodular type survived significantly longer than the children with large cell anaplastic. The children with total resection survived significantly longer than the children with partial resection. The children with radiotherapy or chemotherapy survived significantly longer than the children without chemotherapy (P<0.05). Conclusions MB in most of children is high-grade tu-mors and the prognosis is poor. The pathological type is related with prognosis. Microsurgical total resection is the first choice of treatment. Postoperative radiotherapy and chemotherapy can increase the survival rate.%目的:探讨儿童髓母细胞瘤(MB)的病理特征及其治疗与预后,分析其预后与病理类型的相关性。方法回顾性分析60例MB患儿的病理、治疗结局、及其他临床资料。结果60例MB患儿均为高级别肿瘤,病理类型主要为经典型45例(75.00%),其他各亚型15例(25.00%)。显微手术全切除48例(80.00%),次全切除9例(15.00%

  17. Clinical and pathological characteristics of children with dense deposit disease%小儿致密物沉积病的临床与病理分析

    Institute of Scientific and Technical Information of China (English)

    刘景城; 杨霁云; 肖慧捷; 黄建萍; 姚勇; 李绚; 王素霞

    2009-01-01

    Objective To analysis the clinical and pathological characteristics of children with dense deposit disease (DDD). Methods 12 Children diagnosed as DDD by electron microscope were enrolled in this study. The clinical and pathological data were analyzed. Results Of the 12 cases, 7 were males and 5 females, mean age 9.1±3.9(5-13) years at onset, the duration from onset to renal biopsy was 1 month to 5 years and the follow-up period was 1-9 years. All cases had heavy proteinuria >50 mg/(kg·d), and persistent microscopic hematuria with recurrent gross hematuria during the course. Seven cases had hypertension (≥140/100 mm Hg, 1 mm Hg=0.133 kPa), 5 cases had transient or recurrent abnormal renal function, and mild to severe anemia were observed in 8 cases respectively. All the cases had lower serum C3(0.15-0.55 g/L). Clinically, 10 cases were diagnosed as nephritic syndrome (one case had partial lipodystrophy at the sa me time), and 2 cases were diagnosed as acute nephritic syndrome. Immunofluorescence study showed intense deposition of C3 along GBM, TBM and the wall of Bowman's capsule in a ribbon-like pattern and in the mesangial regions as coarse granules in all the cases. Under light microscopy, 9 cases showed the feature of membrane proliferative glomerulonephritis (MPGN), 1 case with focal segmental glomeruloselerosis (FSGS), 1 case with endocapillary proliferative glomerulonephritis (EnPGN) and 1 case with proliferative sclerosis (PSGN). Crescents were seen in 3 cases. Under electron microscopy, ribbon-like or linear electron-dense intramembranous deposits were identified in the lamina dense of GBM, and often along TBM and the wall of Bowman's capsule. All patients showed steroid resistance. After methylprednisone treatment, some patients showed transient remission. During the followup stage of 1-9 years, 3 cases showed normal urinalysis, 5 cases showed partial remission, 2 cases progressed to end stage renal disease (ESRD) and 2 cases were lost. Conclusion DDD

  18. Clinical and pathological characteristics of microsporidian encephalitis%微孢子虫脑炎一例临床和病理表现

    Institute of Scientific and Technical Information of China (English)

    刘淑萍; 李大年; 麻琳; 徐淑军; 邓小梅; 许军; 刘君鹏; 刁增艳; 周盛年

    2008-01-01

    目的 研究微孢子虫脑炎的临床与病理形态学表现.方法 对1例微孢子虫脑炎患者的临床、脑活体组织检查组织病理特点进行研究.结果 此病呈亚急性或慢性起病,体温大多正常或37.5℃以下,升高见于病情加重出现昏迷时;患者不伴有人类免疫缺陷病毒感染但免疫力低下;全脑多发病灶,有脑膜刺激征;骨髓检查呈感染骨髓象;发病初期类风湿因子升高;中期以后出现间接胆红素升高现象;脑脊液蛋白、免疫球蛋白IgG、IgA升高,细胞学检查示淋巴细胞反应.患者伴有胸膜炎、腹膜炎及膀胱炎.脑MRI表现为双侧大、小脑半球脑白质区见斑片状等长T1、长T2信号影,压水扫描(FLAIR)呈高信号,无明显占位效应,强化扫描病灶呈斑点状及环形强化;神经系统损害症状呈永久性,治疗无效.脑组织病理显示神经元变性、核固缩,有血管周围炎现象,神经元内胞质内可见病原体.Wister大鼠腹腔内注射患者脑脊液2周后出现多脏器内炎症反应,腹腔灌洗液内发现大量病原体.结论 患者伴有多脏器病变,脑内多发病灶,脑组织病理呈炎症反应,Klüver-Barrer-PAS染色法可显示神经元内病原体.动物腹腔注射培养可增加病原体的检出率.%Objective To study the clinical and pathological manifestations of microsporidian encephalitis.Methods The clinical findings and the brain pathological features of a patient with microsporidian encephalitis hospitalized in 2004 were studied.Results The onset was subacute or chronic. The body temperature was usually normal or below 37.5℃,but it rose when patient's condition deteriorated and coma appeaxed.The patient had hypoimmunity but without human immunodeficiency virus infection. Multifocal lesions in the whole brain,signs of meningeal irritation and infective myelogram were observed. Rheumatoid factor increased in the early stage and indirect bilirubin,proteins in cerebrospinal fluid

  19. Language Pathology.

    Science.gov (United States)

    Fletcher, Paul

    1989-01-01

    Discusses the role of linguistics in the investigation of language disorders, focusing on the application of phonetics, descriptive grammatic frameworks, grammatical theory, and concepts from semantics and pragmatics to a variety of disorders and their remediation. Some trends and examples from the field of clinical linguistics are discussed. (GLR)

  20. Brain venous pathologies: MRI findings

    International Nuclear Information System (INIS)

    Purpose: To describe MRI findings of the different brain venous pathologies. Material and Methods: Between January 2002 and March 2004, 18 patients were studied 10 males and 8 females between 6 and 63 years old; with different brain venous pathologies. In all cases brain MRI were performed including morphological sequences with and without gadolinium injection and angiographic venous sequences. Results: 10 venous occlusions were found, 6 venous angiomas, and 2 presented varices secondary to arteriovenous dural fistula. Conclusion: Brain venous pathologies can appear in many different clinical contexts, with different prognosis and treatment. In all the cases brain MRI was the best imaging study to disclose typical morphologic abnormalities. (author)

  1. Pathology of the region of the knee

    Energy Technology Data Exchange (ETDEWEB)

    Aufdermaur, M.

    1981-09-01

    Radiological, clinical and pathologic-anatomical findings seen in four types of disorders of the region of the knee jointare described. An attempt is made to explain the clinical symptomatology on the basis of pathologic-anatomical findings. It is demonstrated that the histology of a giant cell neoplasm does not permit conclusions as to prognosis. Etiology and pathogenesis of villonodular synovitis and of chondrocalcinosis are unexplained. Pathologic-anatomical findings of chondromalacia patellae are those of early osteoarthrosis.

  2. Clinical pathologic analysis of the eat-scratch diseases%猫抓病2例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    王琪

    2009-01-01

    目的 探讨猫抓病的临床病理学特征、诊断及鉴别诊断.方法 对2例猫抓病进行临床病理分析,应用Warthin-Starry嗜银纤维染色进行诊断和鉴别诊断.结果 2例猫抓病患者,1例有明确的被猫咬伤手指史,1例可疑被猫抓咬病史.镜下见大量淋巴结构破坏,多发性、大小不一的圆形结节性肉芽肿性病变.结节中央为含嗜中性粒细胞的中心性坏死,其间见少量类上皮细胞、多核巨细胞等.肉芽肿性结节为非干酪样坏死性.Warthin-Starry嗜银纤维染色发现结节内有大量阳性杆菌.结论 猫抓病常见的病原体为巴尔通氏体,其淋巴结肉芽肿的病理组织学变化酷似性病性淋巴肉芽肿、非干酪性结核等.可根据临床病史、特殊皮肤试验、病理组织学改变及嗜银纤维染色来加以诊断和鉴别诊断.%Objiective To explore clinical pathologic characteristics, diagnosis and differential diagnosis of the cat-scratch diseases. Methods 2 patients with cat-scratch diseases were analyzed by histological observation and Warthin-Starry argentaffine fibers stain. Results One patient had a clearly medical history bitten finger by a roam a-bout cat. Histologically, the nodular was composed of epithelioid cells, multinuclear giant cells with a central necrot-ic. Conclusions The common etiology of the cat-scratch disease were Bartonella hensellae. These lesions greagly re-semble those of lymphogranuloma venereum and non-caseous tuberculosis. The diagnosis and differential diagnosis was based on the history, a specific cutaneous test and Warthin-Starry argentaffine fibers stain.

  3. 小儿紫癜性肾炎的临床病理及远期预后分析%Clinical Pathology and Long-Term Prognosis of Henoch-Schonlein Nephritis in Children

    Institute of Scientific and Technical Information of China (English)

    周玲; 陈钟; 贾劬

    2001-01-01

    Objective To analyze the relationship between the clinical and pathological effects and long-term prognosis in children with Henoch-Schonlein nephritis.Methods Changes of clinical pathology were studied in 32 children with Henoch-Schonlein nephritis and 19 cases of them were followed over an 8 to 14 year period.Results Acute nephritis ranked first(50 ?)and the nephritic syndrome ranked second(40?)in the clinical classification of Henoch-Schonlein nephritis;the majority had pathological changes of Grade???.The rate of recovery of acute nephritis and the nephritic syndrome was 55.6?abd 28.6?,respectively.The rate of recovery and deterioration of Grade??? pathological changes was 43.8?and 12.5?,respectively.Of the patients with Grade??? pathological changes,66.7? deteriorated or died. Conclusions The prognosis of acute nephritis was better than that of the nephritic syndrome,and long-term prognosis is closely associated with the clinical classification and pathology.%目的分析小儿紫癜肾炎的临床、病理与远期预后的关系。方法比较32例紫癜性肾炎的临床病理变化,随访其中19例,随访期限8~14年,了解临床及病理对远期预后的影响。结果小儿紫癜性肾炎的临床分型中以急性肾炎综合征型多见,占50%,肾病综合征型次之占40%;病理变化以Ⅰ~Ⅲ级的痊愈率为43.8%(7/16例),恶化率12.5%(2/16例),Ⅳ~Ⅴ级中66.7%(2/3例)恶化或死亡。结论急性肾炎综合征型远期预后较肾病综合征型好,远期预后与临床分型及病理分级密切相关。

  4. The European Clinical, Molecular, and Pathological (ECMP) Criteria and the 2007/2008 Revisions of the World Health Organization for the Diagnosis, Classification, and Staging of Prefibrotic Myeloproliferative Neoplasms Carrying the JAK2V617F Mutation

    OpenAIRE

    Jan Jacques Michiels; Fibo Ten Kate; Lam, King H.; Wilfried Schroyens; Zwi Berneman; Hendrik De Raeve

    2014-01-01

    OBJECTIVE: The prefibrotic stages of JAK2V617F essential thrombocythemia (ET) and JAK2V617F polycythemia vera (PV) can easily be diagnosed clinically without use of bone marrow biopsy histology. We assessed the 2008 WHO and European Clinical, Molecular, and Pathological (ECMP) criteria for the diagnosis of myeloproliferative neoplasms (MPNs). METHODS: Studied patients included 6 JAK2V617F-mutated ET and 4 PV patients during long-term follow-up in view of critical analysis of the literature...

  5. 上消化道平滑肌肿瘤的临床及病理特点%The clinical and pathological characteristics of upper gastrointestinal smooth muscle tumors

    Institute of Scientific and Technical Information of China (English)

    王静

    2013-01-01

    Objective to analyze the upper gastrointestinal smooth muscle tumors of the clinical pathological features .Methods our hospital 68 cases of patients with upper gastrointestinal smooth muscle tumors of the clinical data and pathological data were retrospectively analyzed ,such as research,to explore the clinical and pathologi-cal characteristics of upper gastrointestinal smooth muscle tumors .Results the positive rate of upper gastrointestinal smooth muscle tumors by endoscopy was 80 .88%, visible during endoscopy nodular tumor mainly uplift,27.94% of the patients with tumor surface ulcers,the positive rate of endoscopic examination is 80.88%.Conclu-sion upper gastrointestinal smooth muscle tumors main show is benign ,confirmed by endoscopy examination accuracy is higher.%目的:分析研究上消化道平滑肌肿瘤的临床表现极其病理特征。方法对我院收治的68例上消化道平滑肌肿瘤患者的临床资料、病理资料等进行了回顾性分析研究,探讨上消化道平滑肌肿瘤的临床及病理特点。结果上消化道平滑肌肿瘤通过内镜检查的确诊率为80.88%,进行内镜检查时可见肿瘤主要为隆起结节状,27.94%患者的肿瘤表面存在溃疡,内镜检查的确诊率为80.88%。结论上消化道平滑肌肿瘤主要表现为良性,通过内镜检查确诊的准确率较高。

  6. CLINICAL BIOCHEMISTRY

    Science.gov (United States)

    Assessment of the health status of animals through measurement of cellular, biochemical, and macromolecular constituents in blood, secretions, and excretions has been variously referred to as clinical chemistry, clinical biochemistry, or clinical pathology. he genesis of this dis...

  7. Curriculum Guidelines for Pathology and Oral Pathology.

    Science.gov (United States)

    Journal of Dental Education, 1985

    1985-01-01

    Guidelines for dental school pathology courses describe the interrelationships of general, systemic, and oral pathology; primary educational goals; prerequisites; a core curriculum outline and behavioral objectives for each type of pathology. Notes on sequencing, faculty, facilities, and occupational hazards are included. (MSE)

  8. Clinical and pathological analysis for seven cases of giant basal cell carcinoma%7例巨大基底细胞癌的临床与组织病理分析

    Institute of Scientific and Technical Information of China (English)

    雷山川; 高敏娜; 朱堂友

    2013-01-01

    Objective To study the clinical and pathologic features for seven cases of giant basal cell carcinoma. Methods Retrospective analysis was conducted on the clinical and pathological data for 7 cases of giant basal cell carcinoma retrospectively. Results Long course of disease and high rate of metastasis as well as site of tissue damaged seriously showed in the cases. Conclusion Karly pathological diagnosis and operation treatment can reduce tissue damage and educe metastasis of tumor and postoperative recurrence as well as possibility of mortality.%目的 探讨巨大基底细胞癌临床与组织病理学特点.方法 回顾性分析比较7例巨大基底细胞癌临床与组织病理学资料.结果 巨大基底细胞癌临床上病程长、肿瘤转移率高、对发生部位的组织器官毁损严重,组织病理为多亚型改变的组织病理相.结论 早期组织病理学检查确诊及手术治疗是减少、减轻对组织、器官毁损的前提,同时也可降低肿瘤的转移率、手术复发率及死亡率.

  9. 肾集合管癌临床及病理分析%Clinical and pathological analysis of collecting duct carcinoma of the kidney

    Institute of Scientific and Technical Information of China (English)

    潘寿华; 阎家骏; 徐国强; 汪朔

    2012-01-01

    目的 分析肾集合管癌(collecting duct carcinoma,CDC)的临床及病理特点. 方法 1999年1月至2010年12月收治CDC患者11例,男6例,女5例.年龄22~67岁,平均55岁.主要症状为血尿、腰腹痛.实验室检查无阳性发现.CT检查示肿瘤直径2.1~8.5 cm,平均5.6 cm.肿瘤位于肾髓质或同时伴有肾皮质、肾盂浸润,边界不清,病变肾脏外形增大,但肾脏轮廓基本存在,增强后呈不均匀轻~中度强化. 结果 8例行根治性肾切除术,3例行姑息性肾切除术.肿瘤切面呈灰白色,浸润性生长;以腺管乳头状结构为主,部分肿瘤细胞呈靴钉状突向腺腔内,肿瘤间质纤维组织增生明显,有较多淋巴细胞及浆细胞浸润;免疫组化染色检查UEA-1、EMA、PNA、HMW-CK表达阳性,而CD10表达阴性.10例获得随访,随访时间0.3 ~8.0年,平均2.8年.随访期间死亡7例,平均生存期为12.5个月,2例无瘤生存分别9个月和8年,1例仍在化疗中,1例失访. 结论 CDC是一种非常少见的肾癌类型,确诊主要依据病理学检查,肿瘤恶性程度高,进展迅速,预后差.%Objective To analyze the clinical and pathological features of collecting duct carcinoma (CDC) of the kidney. Methods 11 patients with CDC were analyzed,among which 6 were males and 5 were females.Their age ranged from 22 to 67 years old with a mean age of 55.4 cases were found by routine health examination,4 cases were presented with gross hematuria and 3 cases had flank or abdomen pain.The CT scan showed an unclear boundary mass in kidney,with tumor sizes from 2.1 to 8.5 cm ( mean 5.6 cm).Only medullary involvement was present on CT in 3 cases,Medullary and cortical involvement in 5 cases,Medullary and pelvic involvement in 2 cases,and all involvement in 1 case.Infiltrative lesion has expanded kidney but maintains reniform contour.Contrast-enhanced CT scan showed lesion mild to moderate enhancement compared with surrounding parenchyma. Results Radical nephrectomy was

  10. Tracking in anatomic pathology.

    Science.gov (United States)

    Pantanowitz, Liron; Mackinnon, Alexander C; Sinard, John H

    2013-12-01

    Bar code-based tracking solutions, long present in clinical pathology laboratories, have recently made an appearance in anatomic pathology (AP) laboratories. Tracking of AP "assets" (specimens, blocks, slides) can enhance laboratory efficiency, promote patient safety, and improve patient care. Routing of excess clinical material into research laboratories and biorepositories are other avenues that can benefit from tracking of AP assets. Implementing tracking is not as simple as installing software and turning it on. Not all tracking solutions are alike. Careful analysis of laboratory workflow is needed before implementing tracking to assure that this solution will meet the needs of the laboratory. Such analysis will likely uncover practices that may need to be modified before a tracking system can be deployed. Costs that go beyond simply that of purchasing software will be incurred and need to be considered in the budgeting process. Finally, people, not technology, are the key to assuring quality. Tracking will require significant changes in workflow and an overall change in the culture of the laboratory. Preparation, training, buy-in, and accountability of the people involved are crucial to the success of this process. This article reviews the benefits, available technology, underlying principles, and implementation of tracking solutions for the AP and research laboratory. PMID:23634908

  11. Experience on clinical application of positron emission tomography with a new radiopharmaceutical preparation Sodium 11C-butyrate in differential diagnosis of pathological volume brain formation

    International Nuclear Information System (INIS)

    Possibilities of the application of new radiopharmaceutical - sodium butyrate, [1-11C] (11C-Butyrate) for differential diagnosis of pathological volume brain formation were studied. Positron emission tomography (PET) of the brain was performed in 24 patients. In addition PET with 18F-FDG was performed in all patients. In 15 out of 24 patients the brain malignant tumor has been discovered, in 4 patients - benign tumors, in 5 - postoperative cysts. Results of the studies showed that the ratio tumor/normal tissue in case of 11C-Butyrate and 18F-FDG application proved to be comparable for all studied histological types of tumors. Malignant tumors in these cases had been visualized as a hot spots of increased uptake 11C-Butyrate (ratio ≥ 1). The obtained data testify to the diagnosis of the pathological volume brain formation

  12. 吸毒人群中医病理因素的临床研究%Clinical research on the pathological factors of TCM of drug users

    Institute of Scientific and Technical Information of China (English)

    杨朝阳; 李灿东; 黄世庚; 吕京和; 庄忠新

    2013-01-01

    Objective To study the characteristics of pathological factors of TCM of drug users. Methods Case-control study was conducted between the drug addicts and the healthy persons. The pathological factors of TCM of drug addicts were collected by categorical identification in terms of syndrome factor. Results The integral frequency of liver syndrome element of drug group was the highest. Compared with the healthy group, the integral means of Five Viscus disease location syndrome element of drug addicts showed significant difference (P<0.01). The syndrome element integral frequency of phlegm, wet and qi stagnation and yin deficiency of drug group were higher. Compared with the healthy group, the integral means of pathological characteristics syndrome element of drug addicts showed significant difference (P<0.01). Conclusion Drug addiction is the result of functional disturbance of several viscus (liver, kidney, spleen) and can be largely attributed to the vacuity-repletion complex pattern. The main pathological characteristics syndrome element of deficiency pattern is yin deficiency, the main pathological characteristics syndrome element of repletion pattern is phlegm, wet and qi stagnation, the disease location mainly lies in liver and kidney.%目的 研究吸毒人群的中医病理因素特点.方法 对吸毒者和健康者进行对照研究,中医病理因素采用证素辨证方法采集.结果 吸毒组肝证素积分频数最高;与健康组相比,吸毒组的五脏病位证素积分值均差异有统计学意义(P<0.01);吸毒组痰、湿、气滞和阴虚等病性证素积分频数最高;与健康组相比,吸毒组的病性证素积分值均差异有统计学意义(P<0.01).结论 毒品成瘾形成是多脏腑(肝、肾、脾)功能失调的表现,多属虚实夹杂之证.虚证病性证素主要以阴虚为主;实证病性证素主要以痰、湿、气滞为主;病位主要在肝、肾.

  13. The Danish Pathology Register

    DEFF Research Database (Denmark)

    Bjerregaard, Beth; Larsen, Ole B

    The National Board of Health, Denmark in 1997 published guidelines for reporting of pathology data and the Danish Pathology Register (DPR) was established.......The National Board of Health, Denmark in 1997 published guidelines for reporting of pathology data and the Danish Pathology Register (DPR) was established....

  14. Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of pathology discrepancies.

    Science.gov (United States)

    Montironi, Rodolfo; Mazzuccheli, Roberta; Scarpelli, Marina; Lopez-Beltran, Antonio; Fellegara, Giovanni; Algaba, Ferran

    2005-06-01

    The Gleason grading system is a powerful tool to prognosticate and aid in the treatment of men with prostate cancer. The needle biopsy Gleason score correlates with virtually all other pathological variables, including tumour volume and margin status in radical prostatectomy specimens, serum prostate-specific antigen levels and many molecular markers. The Gleason score assigned to the tumour at radical prostatectomy is the most powerful predictor of progression after radical prostatectomy. However, there are significant deficiencies in the practice of this grading system. Not only are there problems among practising pathologists but also a relative lack of interobserver reproducibility among experts. PMID:15877724

  15. The Association between the Clinical Symptoms of Heterotopic Gastric Mucosa in the upper Esophagus and its Pathologic Types%上食管胃黏膜异位症的临床与病理分析

    Institute of Scientific and Technical Information of China (English)

    张春芬; 陈宏伟; 李延伟

    2011-01-01

    Objective To investigate the association between the clinical symptoms of heterotopic gastric mucosa in the upper esophagus and its pathologic types. Methods The biopsies were taken from red mucosa for pathological examination when upper esophagus was observed by endoscope in 15 713 cases. Results 14 eases of cardia gastric mucosa and 3 cases of fundic gastric mucosa were detected in 18 patients with unfavorable gulping. 1 case of cardia gastric mucosa and 9 cases of fundic gastric mucosa were detected in 11 patients with local burning sensation or pain. The pathologic types were significantly different. Conclusion The symptoms of heterotopic gastric mucosa in the upper esophagus are closely related with pathologic types.%目的 研究上食管胃黏膜异位症的临床症状与病理特征的关系.方法以在某医院进行胃镜检查的15 713人为研究对象,在常规内镜操作中经食管上段时,观察到边界清楚的红色黏膜,取检进行病理学检查.结果症状表现为下咽不利的患者有18例,其中贲门型胃黏膜有14例,胃底型黏膜3例;局部烧灼感或者疼痛的患者有11例,其中贲门型胃黏膜有1例,胃底型黏膜有9例;其病理学类型存在明显差异.结论 上食管胃黏膜异位症的症状与病理学类型相关.

  16. Mucosal vaccination with formalin-inactivated avian metapneumovirus Subtype C reduces clinical signs of disease but enhances local pathology of turkeys following challenge

    Science.gov (United States)

    Studies were performed to determine if mucosal vaccination with inactivated avian metapneumovirus (aMPV) subtype C protected turkey poults from clinical disease and virus replication following mucosal challenge. Although decreases in clinical disease were observed in vaccinated groups, the vaccine...

  17. High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats.

    Science.gov (United States)

    Meli, M; Kipar, A; Müller, C; Jenal, K; Gönczi, E; Borel, N; Gunn-Moore, D; Chalmers, S; Lin, F; Reinacher, M; Lutz, H

    2004-04-01

    Specified pathogen-free cats were naturally infected with FCoV or experimentally infected with FCoV type I. Seroconversion was determined and the course of infection was monitored by measuring the FCoV loads in faeces, whole blood, plasma and/or monocytes. Tissue samples collected at necropsy were examined for viral load and histopathological changes. Experimentally infected animals started shedding virus as soon as 2 days after infection. They generally displayed the highest viral loads in colon, ileum and mesenteric lymph nodes. Seroconversion occurred 3-4 weeks post infection. Naturally infected cats were positive for FCoV antibodies and monocyte-associated FCoV viraemia prior to death. At necropsy, most animals tested positive for viral shedding and FCoV RNA was found in spleen, mesenteric lymph nodes and bone marrow. Both experimentally and naturally infected cats remained clinically healthy. Pathological findings were restricted to generalized lymphatic hyperplasia. These findings demonstrate the presence of systemic FCoV infection with high viral loads in the absence of clinical and pathological signs. PMID:15123151

  18. THE EFFECTS OF CLINICAL PATHOLOGICAL CONFERENCE IN ROTATION TRAINING OF GENERAL PRACTITIONER IN NEPHROLOGY DEPARTMENT%临床病理讨论会在全科医生肾脏科转岗培训中的效果

    Institute of Scientific and Technical Information of China (English)

    刘海军

    2014-01-01

    Objective To explore the effects of clinical pathological conference in rotation training of gen-eral practitioner in nephrology department to promote the realization of general practice training goal . Methods From August ,2009 to December ,2012 ,65 general practitioners from Linyi City People’s Hospi-tal who have accepted standardized training for general practitioners were enrolled .They actively participa-ted in clinical pathological conference in nephrology department one time a week .theory ,skills and medi-cal record writing At the end of rotation training ,the training effects were assessed in knowledge ,skills and writing medical history .Questionnaires were used to survey general practitioners’ evaluation of the mode of clinical pathological conference .Results The knowledge ,skills and medical record writing were all up to standard ,and the excellence rates were is 60 (92 .31% ) ,62 (95 .38% ) and 58/(89 .23% ) respective-ly .The survey results showed that the general practitioners gave high evaluation to the mode of clinical pathological conference ,and the mode can mobilize the initiative and enthusiasm and can improve the theo-retical and practical ability in the diagnosis and treatment of kidney diseases in community .Conclusion Clin-ical pathological conference has positive effect on general practitioners’ knowledge and practice skills and can help to ensure the realization of general medical teaching goal .%目的:探索临床病理讨论会模式在全科医生肾脏科轮岗培训中的应用效果,促进全科医学培养目标的实现。方法选择2009年8月~2012年12月在临沂市人民医院肾脏科接受规范化培训的全科医生65人,在肾脏科轮岗期间,每周进行1次临床病理讨论会,轮岗结束时考核理论、技能、病历书写等效果,问卷调查全科医生对临床-病理讨论会模式的评价。结果出科时理论、技能考核及病历书写成绩均合格

  19. What Is New in Clinical Microbiology—Microbial Identification by MALDI-TOF Mass Spectrometry: A Paper from the 2011 William Beaumont Hospital Symposium on Molecular Pathology

    OpenAIRE

    Murray, Patrick R.

    2012-01-01

    Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) offers the possibility of accurate, rapid, inexpensive identification of bacteria, fungi, and mycobacteria isolated in clinical microbiology laboratories. The procedures for preanalytic processing of organisms and analysis by MALDI-TOF MS are technically simple and reproducible, and commercial databases and interpretive algorithms are available for the identification of a wide spectrum of clinically ...

  20. Updates of pathologic myopia.

    Science.gov (United States)

    Ohno-Matsui, Kyoko; Lai, Timothy Y Y; Lai, Chi-Chun; Cheung, Chiu Ming Gemmy

    2016-05-01

    Complications from pathologic myopia are a major cause of visual impairment and blindness, especially in east Asia. The eyes with pathologic myopia may develop loss of the best-corrected vision due to various pathologies in the macula, peripheral retina and the optic nerve. Despite its importance, the definition of pathologic myopia has been inconsistent. The refractive error or axial length alone often does not adequately reflect the 'pathologic myopia'. Posterior staphyloma, which is a hallmark lesion of pathologic myopia, can occur also in non-highly myopic eyes. Recently a revised classification system for myopic maculopathy has been proposed to standardize the definition among epidemiological studies. In this META-PM (meta analyses of pathologic myopia) study classification, pathologic myopia was defined as the eyes having chorioretinal atrophy equal to or more severe than diffuse atrophy. In addition, the advent of new imaging technologies such as optical coherence tomography (OCT) and three dimensional magnetic resonance imaging (3D MRI) has enabled the detailed observation of various pathologies specific to pathologic myopia. New therapeutic approaches including intravitreal injections of anti-vascular endothelial growth factor agents and the advance of vitreoretinal surgeries have greatly improved the prognosis of patients with pathologic myopia. The purpose of this review article is to provide an update on topics related to the field of pathologic myopia, and to outline the remaining issues which need to be solved in the future. PMID:26769165

  1. Forms of pathologization

    DEFF Research Database (Denmark)

    Brinkmann, Svend

    before, perhaps due to the malaises of modernity. Instead, we have learned to think and talk about human problems in new ways, viz. ways that involve pathologization. Pathologization, however, is not a unitary phenomenon, and the presentation gives an overview of four types of pathologization, which are...

  2. Middle ear meningiomas: a case series reviewing the clinical presentation, radiologic features, and contemporary management of a rare temporal bone pathology.

    Science.gov (United States)

    Stevens, Kristin L; Carlson, Matthew L; Pelosi, Stanley; Haynes, David S

    2014-01-01

    Meningiomas are the most common extra-axial intracranial neoplasm and frequently develop in the parasagittal region. Rarely, meningiomas may involve the middle ear and mastoid, resulting from contiguous spread of adjacent intracranial tumor, or less commonly as an isolated primary tumor of the middle ear. Patients with primary middle ear meningiomas (MEMs) often present with non-specific otologic complaints including hearing loss, otorrhea and otalgia thereby mimicking common chronic otitis media, while secondary lesions more frequently manifest sensorineural hearing loss, cranial neuropathy and other neurologic symptoms from the associated intracranial component. The radiological appearance of MEMs often overlaps with other tumors of the temporal bone. Therefore, a correct diagnosis cannot always be made prior to surgical biopsy. While gross total resection with preservation of existing neurological function is possible with smaller lesions, complete tumor removal may be extremely morbid with more extensive or adherent MEMs. In such cases, aggressive subtotal resection with close radiologic follow-up should be considered. Given the rarity of the studied condition, the literature addressing MEMs is sparse. The current study reviews ten additional cases of MEMs, highlighting the clinicopathologic and radiological features that distinguish meningiomas from other middle ear and mastoid pathology. PMID:24650749

  3. Related immune response of clinic heterogeneity and pathology in neurocysticercosis%脑囊虫病临床异质性、病理变化与免疫反应

    Institute of Scientific and Technical Information of China (English)

    陈小华; 谷俊朝

    2012-01-01

    脑囊虫病,由猪囊尾蚴寄生于中枢神经系统引起.脑囊虫病临床异质性表现为从无症状到颅内高压、脑积水、蛛网膜炎、癫痫,甚至死亡.脑囊虫病病理变化表现为血脑屏障破坏、脑实质肉芽肿形成、局部及外周多种免疫细胞共同参与.脑囊虫病的临床异质性与病理变化均与宿主抗猪囊尾蚴免疫反应密切相关.本文就与脑囊虫病临床异质性、病理变化相关的抗囊尾蚴免疫、影响因素(囊尾蚴发育阶段、大小、数量、位置、基因组学;宿主年龄、性别、遗传背景)与免疫机制等做一综述.%Neurocysticercosis (NO is caused by infection of the central nervous system with Taenia solium metacestode (Cysticercus). Clinical heterogeneity of NC can range from a totally asymptomatic course to severe illness, with intracra-nial hypertension, hydrocephalus, arachnoiditis, seizures, and even death. Pathologic changes caused by NC include breakdown of the blood-brain barrier, parenchymal granuloma formation, involvement of various local and systemic im-munocytes. Both the clinical heterogeneity of NC and the pathologic changes it leads to are closely related to host immune response. This article reviews the immune response in relation to the clinical heterogeneity and pathologic changes of NC, influencing factors (developmental stages, size, number, location, and genetics of Taenia solium as well as the age, gender, and genetics of the host), and mechanisms of immune response to NC.

  4. Clinical characteristics of different pathological types of sinonasal papilloma%不同病理类型鼻乳头状瘤的临床特点相关分析

    Institute of Scientific and Technical Information of China (English)

    张东东; 林昶

    2016-01-01

    Sinonasal papilloma is a benign condition with the potential for recurrence and malignant change. The distinctive epithelium can give rise to three histologically unique types of papillomas: exophytic, inverted and oncytic papillomas. In this paper, the epidemiology, pathology, etiology, biological behavior and clinical manifestations of the three different pathological types of sinonasal papillomas are reviewed separately.%鼻腔鼻窦乳头状瘤是鼻腔及鼻窦具有复发和恶变潜能的良性肿瘤。组织学上根据上皮形态分为3种类型:内翻性乳头状瘤、外生性乳头状瘤和嗜酸性细胞乳头状瘤。本文从流行病学、组织病理学、病因、临床表现等方面分别对3种不同病理类型鼻腔鼻窦乳头状瘤做一综述。

  5. Predictive value of PSA velocity over early clinical and pathological parameters in patients with localized prostate cancer who undergo radical retropubic prostatectomy

    Directory of Open Access Journals (Sweden)

    Martinez Carlos A.L.

    2004-01-01

    Full Text Available OBJECTIVES: To analyze the behavior of the prostate specific antigen velocity (PSAV in localized prostate adenocarcinoma. MATERIALS AND METHODS: We conducted a retrospective study of 500 men who had localized prostate adenocarcinoma, who underwent radical retropubic prostatectomy between January 1986 and December 1999. The PSAV was calculated for each patient and subsequently, the values were correlated with 5 groups: age, initial PSA value, clinical stage, tumor volume and Gleason score. RESULTS: The behavior of PSAV presented statistic significance with an increment between 1.3 ng/mL and 9.6 ng/mL, ranging from 38.6% and 59.8% when compared with the initial PSA value (p < 0.0001, clinical stage (p = 0.0002, tumor volume (p < 0.0001 and Gleason score (p = 0.0009. CONCLUSION: PSAV up to 2.5 ng/mL/year is associated with factors of good prognosis, such as initial PSA below 10 mg/mL, clinical stage T1, tumor volume below 20% and Gleason score lower than 7.

  6. Parasite antigen-specific, IL-4-, TGFβ- and IL-1- dependent expansion of Th9 cells is associated with clinical pathology in human lymphatic filariasis

    Science.gov (United States)

    Anuradha, Rajamanickam; George, Parakkal Jovvian; Hanna, Luke E.; Chandrasekaran, Vedachalam; Kumaran, Paul; Nutman, Thomas B.; Babu, Subash

    2013-01-01

    Th9 cells are a subset of CD4+ T cells, shown to be important in allergy, autoimmunity and anti-tumor responses. However, their role in human infectious diseases has not been explored in detail. We identified a population of IL-9 and IL-10 co-expressing cells (lacking IL-4 expression) in normal individuals that respond to antigenic and mitogenic stimulation but are distinct from IL-9+ Th2 cells. We also demonstrate that these Th9 cells exhibit antigen –specific expansion in a chronic helminth infection (lymphatic filariasis). Comparison of Th9 responses reveals that individuals with pathology associated with filarial infection exhibit significantly expanded frequencies of filarial antigen induced Th9 cells but not of IL9+Th2 cells in comparison to filarial-infected individuals without associated disease. Moreover, the per cell production of IL-9 is significantly higher in Th9 cells compared to IL9+Th2 cells, indicating that the Th9 cells are the predominant CD4+ T cell subset producing IL-9 in the context of human infection. This expansion was reflected in elevated antigen stimulated IL-9 cytokine levels in whole blood culture supernatants. Finally, the frequencies of Th9 cells correlated positively with the severity of lymphedema (and presumed inflammation) in filarial diseased individuals. This expansion of Th9 cells was dependent on IL-4, TGFβ and IL-1 in vitro. We have therefore a identified an important human CD4+ T cell subpopulation co – expressing IL-9 and IL-10 but not IL-4 that is whose expansion is associated with disease in chronic lymphatic filariasis and could potentially play an important role in the pathogenesis of other inflammatory disorders. PMID:23913964

  7. Clinical and pathologic analysis on 23 cases of uterine papillary serous carcinoma%子宫内膜浆液性乳头状癌23例临床与病理分析

    Institute of Scientific and Technical Information of China (English)

    王卉

    2010-01-01

    目的 通过对子宫内膜浆液性乳头状癌(UPSC)的临床及病理特征的分析,探讨其合理的治疗方法.方法 自2002年6月至2008年12月我院收治子宫内膜浆液性乳头状癌患者23例,对其临床病理、诊断方法、治疗方法及预后进行回顾性分析.结果 全部患者病例采用手术治疗,术后辅助放疗和(或)化疗者17例.Ⅲ、Ⅳ期患者占56.5%,52.2%的患者肌层浸润深度超过1/2肌层(12/23),52.2%有子宫外扩散(12/23),腹膜后淋巴结转移率为54.5%(6/11),86.6%患者雌孕激素受体阴性.预后差,随访期内12例死亡.结论 UPSC少见,临床诊断困难,依靠病理学检查可以确诊.子宫内膜浆液性乳头状癌有其独特的临床病理特征,与普通的子宫内膜癌明显不同,肿瘤高度恶性,预后差,合理的个体化综合治疗可延长生存期.%Objective To study the rational therapy for uterine papillary serous carcinoma (UPSC) and analyze its clinical and pathologic features. Methods A retrospective study was conducted on incidence, clinical characteristics,pathological feature,diagnosis and treatment,prognosis of 23 patients with UPSC,who was admitted in our hospital from January 2000 to June 2006.Results All the patients underwent operation, and 17 cases received postoperative radiotherapy and(or) chemotherapy. Among all the patients with UPSC,56.5% was stage Ⅲ and Ⅳ;52.2% with deep myometrial invasion;Estrogen or progestin receptors were negative in 86.6% cases.12 cases died during the follow ing up period, indicating poor prognosis.Conclusions UPSC is an uncommon tumor. It is difficult to make the diagnosis for clinicians.UPSC can be surely diagnosed with clinical pathology.The clinical and pathologic features of UPSC are different from the common endometrial carcinoma. Rational individu alized treatment can prolong survival time.

  8. Analysis of the clinical, neuro-electrophysiological and pathological features of the lipid storage myopathy%脂质沉积性肌病的临床、神经电生理和骨骼肌病理分析

    Institute of Scientific and Technical Information of China (English)

    吕海东; 瞿千千; 张燕; 陈芳; 钱琪; 秦东香; 李增富

    2012-01-01

    Objective To investigate the features of clinical manifestations, EMG and pathology of lipid storage myopathy (LSM). Methods Retrospective analysis of the features of clinical manifestations, nerve conduction and pathology of 16 LSM patients was done. Results Most LSM patients showed sub-acute or chronic with fluctuating proximal limbs weakness and slight muscle atrophy. The muscle enzyme of the patients had increased differently and most EMG showed myogenic lesions, but the treatments with hormones or riboflavin was usually invalid. LSM was often clinically misdiagnosed as polymyositis, muscular dystrophy, myocarditis and gastrointestinal disease. Muscle pathology was characterized by a large number of muscle fibers fulfilled with uniform of the sieve-like vacuoles, and parts of them confluent into a slit-like bubble. The presence of excessive lipid droplets in the Type I fibers was clearly seen with the oil red 0 staining. Electron microscopy of 4 patients revealed there was a large amount lipid deposition between myofibrils, and one of them was accompanied by increasing of abnormal mitochondria. Conclusions Fatigue and weakness was the main clinical manifestations of LSM which belong to one of the lipid metabolism myopathy, with significant weakness and slight muscle atrophy. Hormones and riboflavin usually show a good effect, and muscle pathological examination is one of the most important way for LSM diagnosis.%目的 探讨脂质沉积性肌病(LSM)的临床表现、神经电生理及肌肉病理特点.方法 回顾分析16例LSM的临床表现、肌电图和神经传导、肌肉活检病理改变.结果 LSM主要临床特点为亚急性或慢性起病,以近端肌无力为主,症状呈波动性,肌无力重而肌萎缩轻.血清肌酶有不同程度的升高,肌电图多为肌源性损害,激素、核黄素治疗有效.临床上容易误诊为多发性肌炎、肌营养不良症、心肌炎、胃肠道疾病等.肌肉病理学特点为肌纤维内可见大

  9. The clinical, pathological, and recent follow-up of pure mitochondrial myopathy%单纯线粒体肌病的临床病理及近期随访

    Institute of Scientific and Technical Information of China (English)

    喻绪恩; 石永光; 王训; 韩咏竹; 杨任民; 程楠; 胡文彬; 胡纪源; 李凯

    2012-01-01

    Objective To report the clinical, muscle pathological findings and follow - up results of four cases diagnosed with pure mitochondrial myopathy, but they had been misdiagnosed as polymyositis, muscular dystrophy, spinal muscular atrophy and so on. Methods The clinical, electrophysiological and muscle biopsy pathology, and recent follow - up results were retrospectively analysed in the 4 patients. Results The clinical performance of the four cases was limb proximal muscle weakness and muscle atrophy. The lactic acid of 2 cases increased, and the other 2 normal. The creatine kinase of three cases increased slightly, and the other 1 normal. EMG showed that 3 cases had myogenic damage and one case had neurogenic damage. RRF were seen in the muscle tissue pathology of four cases. A large number of blue fibers were found in 1 case double staining of S/C. The four cases had improved to varying degrees by low - dose hormone Bu-tylphthalide, large doses of coenzyme Q10, vitamin B2, and comprehensive treatment when they had been followed -up for three months. Three cases returned to normal work and one case's improvement was not obvious when followed in 6 months. Conclusion The pure mitochondrial myopathy is not specific in clinical and electrophysiological examination, but its muscle biopsy pathology and tissue enzymatic staining are indispensable in diagnosing the disease, and an early mitochondrial protection treatment may be a benign course of the disease.%目的 报道4例曾被误诊为多发性肌炎、肌营养不良症和脊肌萎缩症而后被确诊的单纯线粒体肌病的临床、肌肉病理表现和随访结果.方法 对4例患者的临床、肌肉组织病理和近期随访结果进行总结和回顾性分析.结果 4例患者临床均表现为四肢近端肌无力和肌萎缩,血乳酸2例升高、2例正常,肌酸激酶3例轻度升高、1例正常,肌电图3例肌源性损害、1例神经源性损害.肌肉组织病理4例均可见RRF,1

  10. Cutaneous vasculitides: Clinico-pathological correlation

    OpenAIRE

    Gupta Suruchi; Handa Sanjeev; Kanwar Amrinder; Radotra Bishan; Minz Ranjana

    2009-01-01

    Background: Cutaneous vasculitis presents as a mosaic of clinical and histological findings. Its pathogenic mechanisms and clinical manifestations are varied. Aims: To study the epidemiological spectrum of cutaneous vasculitides as seen in a dermatologic clinic and to determine the clinico-pathological correlation. Methods: A cohort study was conducted on 50 consecutive patients clinically diagnosed as cutaneous vasculitis in the dermatology outdoor; irrespective of age, sex and duration...

  11. Clinical pathologies of 366 irregular vaginal bleeding patients with diagnostic curettage%阴道不规则出血患者366例诊断性刮宫临床病理分析

    Institute of Scientific and Technical Information of China (English)

    李花芬

    2012-01-01

      Objective: to explore the pathologies of patients with irregular vaginal bleeding using diagnostic curettage. Methodology: 366 irregular vaginal bleeding patients visited and received diagnostic curettage in our hospital during 2006 to 2011 were reviewed in terms of clinical pathology. Among these subjects, 210 were divided into the manopause group (including those in perimenopause and postmanopause stage), while the rest 156 belonged to non-menopause group. Results:The causal analysis of vaginal bleeding revealed that 178 cases were related to functional endometrium, 148 were due to dysfunctional endometrium, 35 were pertinent to gestational diseases, and 5 were induced by endometrial carcinoma. Major pathology for manopause group is endometrial dysfunction, whereras most patients of non-manopause group live with functional endometrium. Conclusion:irregular uteral bleeding is a disease syndrome characterized by complex etiologies and various pathologies. Endometrial curretage is found with definite accuracy in the diagnosis of irregular viginal bleeding.%  目的:探讨阴道不规则出血诊断性刮宫的病理类型。方法:收集我院2006年-2011年期间阴道不规则出血患者366例,其中绝经组210例(包括围绝经期和绝经后期),非绝经组156例,都进行刮宫病理诊断。结果:引起阴道出血的原因主要是功能性内膜178例,功能失调性内膜148例,与妊娠相关疾病35例,内膜癌5例。绝经组以功能失调性内膜病理为主,非绝经组以功能性内膜病理为主。结论:阴道不规则出血病因复杂,病理类型多样,诊断性刮宫病理分析能取得比较好的诊断效果。

  12. Manifestações clínicas e fonoaudiológicas na Síndrome de Turner: estudo bibliográfico Clinical and speech, hearing and language pathology manifestations on Turner Syndrome: bibliographical study

    Directory of Open Access Journals (Sweden)

    Suhamy Aline Mandelli

    2012-02-01

    Full Text Available TEMA: síndrome genética e achados fonoaudiológicos. OBJETIVO: descrever as manifestações clínicas e fonoaudiológicas em indivíduos com a Síndrome de Turner CONCLUSÃO: foram levantados 23 artigos sobre a Síndrome de Turner dos quais 7 discorriam sobre a audição e suas alterações nesses indivíduos, 6 sobre linguagem receptiva e/ou expressiva e praxia, 5 sobre aspectos psicológicos e cognitivos além de 28 artigos referentes às manifestações clínicas em geral. Por meio do levantamento bibliográfico pode-se observar que as manifestações fonoaudiológicas na Síndrome de Turner são pouco estudadas e, dentro da fonoaudiologia as manifestações audiológicas como perda de audição e otites são as mais estudadas, ao contrário dos aspectos práxicos e de recepção/ expressão da linguagem.BACKGROUND: genetic syndrome and Speech, Hearing and Language Pathology findings. PURPOSE: to describe the clinical and speech, hearing and language manifestations in subjects with Turner syndrome. CONCLUSION: twenty-three articles on Turner' syndrome were collected, of which 7 described hearing and its alterations in these subjects, 6 described the receptive and/or expressive language and praxis, 5 described the psychological and cognitive aspects, besides those, 28 articles referred to the clinical manifestations. Through the literature research it was observed that speech, hearing and language manifestations of Turner syndrome are little studied and, within Speech, Hearing and Language Pathology, hearing manifestations such as hearing loss and ear infections are the most studied, unlike the issues of praxis and language reception/expression.

  13. Impact of Timing and Dosage of a Fluoroquinolone Treatment on the Microbiological, Pathological, and Clinical Outcomes of Calves Challenged with Mannheimia haemolytica.

    Science.gov (United States)

    Lhermie, Guillaume; Ferran, Aude A; Assié, Sébastien; Cassard, Hervé; El Garch, Farid; Schneider, Marc; Woerhlé, Frédérique; Pacalin, Diane; Delverdier, Maxence; Bousquet-Mélou, Alain; Meyer, Gilles

    2016-01-01

    The efficacy of an early and low inoculum-adjusted marbofloxacin treatment was evaluated on microbiological and clinical outcomes in calves infected with 4.10(7) CFU of Mannheimia haemolytica A1. Twenty-two calves were included based on their rectal temperature rise in the 10 h after challenge and allocated in four groups, receiving a single intramuscular injection of saline (CON), 2 mg/kg marbofloxacin 2-4 h after inclusion (early treatment, E2), 2 or 10 mg/kg marbofloxacin 35-39 h after inclusion (late treatments, L2, L10). In CON calves, M. haemolytica DNA loads in bronchoalveolar lavages continuously increased from inclusion to day 4, and were associated with persistent respiratory clinical signs and lung lesions. At times of early and late treatments, M. haemolytica loads ranged within 3.5-4 and 5.5-6 log10 DNA copies/mL, respectively. Early 2 mg/kg marbofloxacin treatment led to rapid and total elimination of bacteria in all calves. The late treatments induced a reduction of bacterial loads, but 3 of 6 L2 and 1 of 6 L10 calves were still positive for M. haemolytica at day 4. Except for CON calves, all animals exhibited clinical improvement within 24 h after treatment. However, early 2 mg/kg treatment was more efficacious to prevent pulmonary lesions, as indicated by the reduction of the extension and severity of gross lesions and by the histopathological scores. These results demonstrated for the first time that a reduced antibiotic regimen given at an early stage of the disease and targeting a low bacterial load could be efficacious in a natural bovine model of pneumonia. PMID:26973615

  14. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. II. Juxtacortical cartilage tumors

    Energy Technology Data Exchange (ETDEWEB)

    Brien, E.W. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)]|[Musculoskeletal Tumor Service, Orthopaedic Hospital, Los Angeles, CA (United States); Mirra, J.M.; Luck, J.V. Jr. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)

    1999-01-01

    In part I, we reviewed the varied clinical presentations, pathogenesis, histologic findings, radiologic findings, and treatment of intramedullary cartilaginous lesions of bone. In this section, we will evaluate our cases and consultations of juxtacortical cartilaginous tumors. Radiographic differential diagnosis includes the numerous juxtacortical lesions particularly osteochondroma, parosteal chondroma, Trevor`s disease, trauma (fracture and periostitis ossificans), and the low- and high-grade surface osteosarcomas. By emphasizing pathogenesis in conjunction with radiographic and histologic findings, pitfalls in diagnosis and subsequent treatment can be avoided in such cases. (orig.) With 32 figs., 2 tabs., 32 refs.

  15. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. II. Juxtacortical cartilage tumors

    International Nuclear Information System (INIS)

    In part I, we reviewed the varied clinical presentations, pathogenesis, histologic findings, radiologic findings, and treatment of intramedullary cartilaginous lesions of bone. In this section, we will evaluate our cases and consultations of juxtacortical cartilaginous tumors. Radiographic differential diagnosis includes the numerous juxtacortical lesions particularly osteochondroma, parosteal chondroma, Trevor's disease, trauma (fracture and periostitis ossificans), and the low- and high-grade surface osteosarcomas. By emphasizing pathogenesis in conjunction with radiographic and histologic findings, pitfalls in diagnosis and subsequent treatment can be avoided in such cases. (orig.)

  16. CLINICAL AND REPRODUCTIVE PATHOLOGICAL CHANGES ASSOCIATED WITH BRUCELLA MELITENSIS AND ITS LIPOPOLYSACCHARIDES IN FEMALE MICE VIA ORAL INOCULATION

    OpenAIRE

    Faez Firdaus Jesse Abdullah; Lawan Adamu; Nur Hazirah; Abdinasir Yusuf Osman; Rozaihan Mansor; Abdul Wahid Haron; Mohd Zamri Saad; Abdul Rahman Omar; Abdul Aziz Saharee

    2013-01-01

    Brucella melitensis (B. melitensis) are Gram-negative, aerobic, facultative intracellular bacteria that cause brucellosis that usually leads to abortion in sheep and goats. Three groups of equal number of 24 healthy female mice were used as animal models. They were orally inoculated with 0.4 mL of phosphate Buffered Saline (PBS-Control group), 0.4 mL of 109 cfu of B. melitensis and 0.4 mL of Lipopolysaccharides (LPS) extracted from 109cfu of B. melitensis (both as treatment groups). Clinical ...

  17. Clinical pathological analysis of primary vermiform appendix Burkitt's lymphoma%阑尾原发Burkitt淋巴瘤临床病理观察

    Institute of Scientific and Technical Information of China (English)

    曾林华; 马丽梅

    2012-01-01

    目的:探讨阑尾原发Burkitt淋巴瘤(BL)的临床病理特点、免疫表型及分子生物学特征.方法:运用组织形态及免疫组化,EB病毒(EBER)原位杂交方法研究1例发生在阑尾的Burkitt淋巴瘤,并结合文献进行分析讨论.结果:阑尾Burkitt淋巴瘤(BL)形态学表现为肿瘤细胞弥漫一致性增生的中等大小细胞浸润,部分瘤细胞周围空晕伴有星空现象.免疫组化显示,肿瘤细胞LCA,CD20及CD10均为阳性,Ki-67大于80%阳性,CD99,CD3p,Mpo阴性,原位杂交EBER阴性.结论:原发于阑尾Burkitt淋巴瘤(BL)非常罕见,属高度侵袭性.应与其他类型淋巴瘤相鉴别,需结合组织形态及免疫组化,原位杂交等为临床诊断和及时治疗提供依据.%Objective:To observe the clinicopathologic feature, immunophenotype and molecular biology character of primary vermiform appendix Burkitts lymphoma. Methods: A case of primary vermiform appendix Burkitt's lym-phoma was studied by the means of histological observation, immunohistochemistry and EB virus hybridization in situ. The feature was discussed with the related literature. Results: Primary vermiform appendix Burkitts lymphoma displayed asystematic hyperplastic tumour cell infiltrated by medium sized cell, part neoplastic cell surrounded by kaino- areolae and starry sky phenomenon in histology. The immunohistochemical result of LCA, CD20 and CD10 was positive. That of CD99, CD3p and Mpo was negative. Positive rate of Ki - 67 was above 80%. EBER was negative in situ hybridization. Conclusion: Primary vermiform appendix Burkitts lymphoma is exceptional invasive tumor, differing from other types of lymphoma. Histological observation, immunohistochemistry and in - situ hybridization are fundamental pathologic diagnosis means.

  18. Relationship between completement 3 and the clinical and pathological features of diabetic nephropathy%补体C3与糖尿病肾病临床病理的关系

    Institute of Scientific and Technical Information of China (English)

    杨莉莉; 刘东伟; 刘章锁

    2013-01-01

    目的 探讨补体C3与糖尿病肾病临床与病理的关系.方法 选择116例于郑州大学第一附属医院肾脏内科经肾穿刺活检证实为糖尿病肾病的患者为研究对象,搜集患者肾活检病理资料,分析不同肾脏病理类型补体C3沉积的阳性率;进而以补体C3为依据,分为C3阳性组和阴性组,分别搜集两组的病史、相关实验室检查等临床及病理资料,比较不同组别患者临床和病理资料的差异.结果 补体C3在糖尿病肾病不同病理类型沉积的阳性率比较差异无统计学意义(P>0.05);补体C3沉积阳性组在病程、24h尿蛋白定量和糖化血红蛋白均高于补体C3沉积阴性组,差异有统计学意义(P<0.05);补体C3沉积阳性组较阴性组有较高的活动指数(6.5±1.9 vs4.5±1.2)和较低的慢性指数(4.8±1.7 vs5.9±2.4),差异有统计学意义(P<0.05).结论 补体C3在糖尿病肾病患者肾脏的沉积率较高,可能参与糖尿病肾病的发病及影响患者预后.%Objective To investigate the relationship between complement 3 and the clinical pathological features of diabetic nephropathy.Methods Pathological materials were collected from 116 patients with renal biopsy-proven diabetic nephropathy,and the deposition rate of complement 3 among different pathological types was analyzed.And then based on whether the renal biopsy speciments were deposited by complement 3,the cases were divided into two groups and the clinical pathological features between the two groups were compared.Results There was no significant difference of the deposition rate of complement 3 among different pathological types (P > 0.05).The group with complement 3 deposited has longer disease history,heavier proteinuria,and higher glycosylated hemoglobin (P < 0.05).Also the group with complement 3 deposited had higher activitation index and lower chronic index (P < 0.05).Conclusions The deposition rate of complement 3 was high in diabetic nephropathy

  19. Serum and Urine Neutrophil Gelatinase-associated Lipocalin was related with clinical and pathological features in IgA nephropathy%血、尿NGAL与IgA肾病临床与病理的相关性研究

    Institute of Scientific and Technical Information of China (English)

    陈薪薪; 陈朝生; 陈宇; 吕吟秋; 陈波; 李凡凡; 陈孝倩; 许菲菲

    2013-01-01

    目的:探讨血、尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平与IgA肾病(IgAN)患者临床与病理表现的关系.方法:选择初次诊治经肾活检病理检查确诊为IgAN且未经激素或免疫抑制剂治疗的患者40例,同时选择10例健康体检者作为对照.收集临床和病理资料,应用酶联免疫吸附法(ELISA)检测血、尿NGAL水平,并分别用IgAN牛津分型和Katafuchi半定量标准对病理进行评分.分析血、尿NGAL与IgAN患者临床及病理指标的相关性.结果:血、尿NGAL反映IgAN肾功能情况较血肌酐(Scr)、血尿素氮(BUN)更敏感,与高血压、Scr、BUN、牛津分型的系膜增殖积分(M)、间质纤维化或小管萎缩(T)以及Katafuchi分型的系膜增殖、局灶节段病变、球性硬化、炎细胞浸润、间质纤维化、肾小管萎缩、血管壁增厚、小动脉玻变等多个指标相关性分析差异均有统计学意义(P0.6,P 0. 6, P < 0. 01 ). Receiver operating characteristic( ROC ) indicated that sNGAL and uNGAL were more sensitive than Scr and eGFR on reflecting the pathological damage in renal tubule and interstitium, while sNGAL was a more sensitive and specific than uNGAL. Conclusion: sNGAL and uNGAL were closely related with clinical and pathological features of IgA nephropathy. sNGAL and uNGAL were more sensitive and specific on reflecting the clinical and pathological lesions in IgAN , especially in renal tubule and interstitium. sNGAL and uNGAL could be sensitive markers to evaluate renal damage in IgA nephropathy.

  20. Current role of cardiac and extra-cardiac pathologies in clinically indicated cardiac computed tomography with emphasis on status before pulmonary vein isolation

    International Nuclear Information System (INIS)

    Purpose: The aim of this study was to assess the incidence of cardiac and significant extra-cardiac findings in clinical computed tomography of the heart in patients with atrial fibrillation before pulmonary vein isolation (PVI). Materials and Methods: 224 patients (64 ± 10 years; male 63%) with atrial fibrillation were examined by cardiac 64-slice multidetector CT before PVI. Extra-cardiac findings were classified as 'significant' if they were recommended to additional diagnostics or therapy, and otherwise as 'non-significant'. Additionally, cardiac findings were documented in detail. Results: A total of 724 cardiac findings were identified in 203 patients (91% of patients). Additionally, a total of 619 extra-cardiac findings were identified in 179 patients (80% of patients). Among these extra-cardiac findings 196 (32%) were 'significant', and 423 (68%) were 'non-significant'. In 2 patients (1%) a previously unknown malignancy was detected (esophageal cancer and lung cancer, local stage, no metastasis). 203 additional imaging diagnostics followed to clarify the 'significant' findings (124 additional CT, costs 38,314.69 US dollars). Overall, there were 3.2 cardiac and 2.8 extra-cardiac findings per patient. Extra-cardiac findings appear significantly more frequently in patients over 60 years old, in smokers and in patients with a history of cardiac findings (p < 0.05). Conclusion: Cardiac CT scans before PVI should be screened for extracardiac incidental findings that could have important clinical implications for each patient. (orig.)

  1. Comparison of the clinical and pathological features between patients with recurrent metastatic breast carcinoma and patients with initially metastatic breast carcinoma

    International Nuclear Information System (INIS)

    Objective was to compare initial metastatic breast carcinoma (MBC) with recurrent MBC and assess their biologic phenotypes and clinical behaviors. A comparison of clinical and biological characteristics and median overall survival times were assessed in the 251 patients with MBC at the Division of Medical Oncology, Ege University School of Medicine and the Division of radiation Oncology, Tepecik Government Hospital, Izmir, Turkey between 1995 and 2004. Hormone receptors, c-erb B-2,ki-67 and p53 expressions were performed by immunohistochemistry. Out of 251 MBC patients, 206 patients had recurrent MBC and 45 had initial MBC. Regarding survival there was no difference between the recurrent MBC group and the initial MBC group. The initial MBC group had a higher proportion of T4 tumors (46% versus 27%), a lower proportion of T-1-2 tumors (31% versus 55%; p=0.01), and higher percentage of patients with high Ki-67 expression (64% versus 49%; p=0.05). Multivariate analysis showed that T stage was an independent prognostic factor (p=0.02). Patients with initial MBC tended to present with larger tumors. This relationship can be explained by delayed diagnosis. The potential for reducing death rates from breast cancer is contingent on educational improvement and increased screening rates. (author)

  2. 62例成人紫癜性肾炎临床与病理分析%Clinical and pathological manifestations of 62 patients with Henoch-Schonlein Purpura nephritis

    Institute of Scientific and Technical Information of China (English)

    范俊英; 王彩丽; 刘丽萍; 王慧

    2012-01-01

    目的 分析成人紫癜性肾炎患者的临床表现和肾脏病理特征.方法 回顾收集62例成人紫癜性肾炎患者的临床资料,分析其临床表现与病理分级分布情况.结果 肾病综合征组与血尿伴蛋白尿组、单纯血尿或蛋白尿组血比较,肌酐水平差异有统计学意义[(203± 132) μmol/L,(79±32) μmol/L,(81 ±24) μmol/L].补体C3、血沉和IgA水平在3组之间差异无统计学意义.血尿伴蛋白尿者病理分型以Ⅱ级(12例)和Ⅲa级(16例)为主,Ⅳ级4例;单纯血尿或蛋白尿者以Ⅱ级和Ⅲb级为主(各4例),Ⅲa级和Ⅵa级各2例;肾病综合征以Ⅲa级和Ⅳa级为主(各4例),Ⅲb、Ⅳb、Ⅴ级各2例,Ⅵ级4例;肾衰竭8例,均为肾病综合征表现,肾病综合征组与其他两组病理分级比较,病理改变较重.结论 成人紫癜性肾炎临床表现与病理分型多种多样,血清肌酐与蛋白尿在一定程度上可以反映病情,肾病综合征、肾小球新月体是紫癜性肾炎预后不良的危险因素.%Objective To analyze the clinical manifestations and pathological features of Henoch -Schonlein purpura nephritis patients. Methods The clinical data of 62 patients with purpura nephritis were analyzed restrospectively. And the clinical manifestations, the grade and distributions of renal pathology were analyzed. Results Patients were divided into the nephritic syndrome group, hematuria combined with proteinuria group, simple hematuria group, and the simple proteinuria group. The serum creatinin level was significantly different between the nephritic syndrome group and the hematuria combined with proteinuria group, the simple hematuris group and proteinuria group[(79?32)u,mol/L], the simple hematuria or simple proteinuria group [(81?4)u,mol/LJ, but the nephrotic syndrome group [(203 ?132) u,mol/L], but there was no significant difference in serum C3 level, ESR and IgA level between the groups. The most common pathological manifestations were Grade II

  3. Genesis of Oral Pathology as a Distinct Dental Specialty

    OpenAIRE

    Souparna Roy

    2016-01-01

    Today, oral pathology as a subject has distinctly developed as a specialty of dentistry which impregnates other specialties like pathology, molecular biology and genetics. It has been christened now as oral and maxillofacial pathology and is an integral part of the d ental curriculum providing the crucial link between basic sciences and clinical dentistry. Pathology of the dental and oral tissues has been there since the beginning of dentistry. It came to be rec...

  4. Current role of cardiac and extra-cardiac pathologies in clinically indicated cardiac computed tomography with emphasis on status before pulmonary vein isolation

    Energy Technology Data Exchange (ETDEWEB)

    Sohns, J.M.; Lotz, J. [Goettingen University Medical Center (Germany). Inst. for Diagnostic and Interventional Radiology; German Center for Cardiovascular Research (DZHK), Goettingen (Germany); Menke, J.; Staab, W.; Fasshauer, M.; Kowallick, J.T.; Zwaka, P.A.; Schwarz, A. [Goettingen University Medical Center (Germany). Inst. for Diagnostic and Interventional Radiology; Spiro, J. [Koeln University Hospital (Germany). Radiology; Bergau, L.; Unterberg-Buchwald, C. [Goettingen University Medical Center (Germany). Cardiology and Pneumology

    2014-09-15

    Purpose: The aim of this study was to assess the incidence of cardiac and significant extra-cardiac findings in clinical computed tomography of the heart in patients with atrial fibrillation before pulmonary vein isolation (PVI). Materials and Methods: 224 patients (64 ± 10 years; male 63%) with atrial fibrillation were examined by cardiac 64-slice multidetector CT before PVI. Extra-cardiac findings were classified as 'significant' if they were recommended to additional diagnostics or therapy, and otherwise as 'non-significant'. Additionally, cardiac findings were documented in detail. Results: A total of 724 cardiac findings were identified in 203 patients (91% of patients). Additionally, a total of 619 extra-cardiac findings were identified in 179 patients (80% of patients). Among these extra-cardiac findings 196 (32%) were 'significant', and 423 (68%) were 'non-significant'. In 2 patients (1%) a previously unknown malignancy was detected (esophageal cancer and lung cancer, local stage, no metastasis). 203 additional imaging diagnostics followed to clarify the 'significant' findings (124 additional CT, costs 38,314.69 US dollars). Overall, there were 3.2 cardiac and 2.8 extra-cardiac findings per patient. Extra-cardiac findings appear significantly more frequently in patients over 60 years old, in smokers and in patients with a history of cardiac findings (p < 0.05). Conclusion: Cardiac CT scans before PVI should be screened for extracardiac incidental findings that could have important clinical implications for each patient. (orig.)

  5. Mioclonias velo-palatinas: estudo clínico e histo-patológico de um caso Palatal myoclonics: a case report with clinical and pathological studies

    Directory of Open Access Journals (Sweden)

    Wilson Luiz Sanvito

    1971-06-01

    Full Text Available São feitas considerações clínicas e anátomo-patológicas sobre as mioclonias velopalatinas a propósito de um caso em que estas hipercinesias se estendiam também à faringe e ao diafragma (mioclonias velofaringodiafragmáticas. A paciente, de 82 anos de idde, foi internada com quadro caracte- rizado por torpor, paresia braquiofacial direita e afasia do tipo misto. Os familiares informavam que a paciente há aproximadamente 6 meses vinha apresentando dificuldade progressiva na marcha e na fala. Ao exame neurológico chamava a atenção a presença de mioclonias velofaringodiafragmáticas, rítmicas e de alta freqüência, que persistiam mesmo durante o sono e, ulteriormente, no estado de coma. Do ponto de vista anátomo-patológico ficou evidenciada a presença de lesões vasculares isquémicas acometendo ambos os núcleos denteados. Ao exame das olivas bulhares observou-se, bilateralmente, lesões neuronais múltiplas caracterizadas por hipertrofia dendrítica e vacuolizações irregulares. O comprometimento do complexo dento-olivar é salientado.A case of palatal myoclonus is reported and the clinical and neuropathological aspects are studied. The patient, a woman aged eighty two, during the clinical course of the disease showed stupor, right brachial monoplegia, aphasia, epileptic seizures and myoclonus involving the palate, pharynx and diaphragm (palatopharyngodiaphragmatic myoclonus. The movements were not influenced by sleep and remained during the coma. The post-mortem findings revealed generalized arteriosclerotic vascular changes with scattered areas of softening in the cortex, brain stem and cerebellum. The significance of a pathway directly linking the dentate nucleus of the cerebellum and the contralateral inferior olive (the dentato-olivary pathway is stressed.

  6. Canine Parvovirus Disease Pathology and Clinical Observation%犬细小病毒病的病理观察及临床治疗

    Institute of Scientific and Technical Information of China (English)

    王守山

    2011-01-01

    犬细小病毒病是由犬细小病毒(Canine parvovirus,CPV)引起的一种高度接触性传染病,临床上以剧烈呕吐、排血样粪便或心肌炎为特征.病犬和带毒犬是该病的主要传染源,临床症状表现为两种类型:心肌炎型和肠炎型,造成胃肠、心脏严重的组织病变.其中,肠炎型较为常见.犬细小病毒病在感染的初期,如果能够准确诊断,及早治疗,采取综合性治疗措施,限制病毒血症的程度和持续时间,可取得理想的治疗效果.%Canine parvovirus disease is caused by canine parvovirus(Canine parvovirus,CPV) causes a highly contagious disease,the clinical to severe vomiting,stool or blood discharge is characterized by myocarditis.Infected dogs,and dogs are the main source of infection,disease,clinical symptoms of two types: type myocarditis and enteritis-type,resulting in gastrointestinal,heart,severe tissue lesions.Among them,the more common type of colitis.Canine parvovirus disease in the early stages of infection,if an accurate diagnosis,early treatment,comprehensive treatment measures taken to limit the degree of viremia and duration,can achieve the desired therapeutic effect.

  7. True recurrence vs. new primary ipsilateral breast tumor relapse: An analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management

    International Nuclear Information System (INIS)

    Purpose: The purpose of this study was to classify all ipsilateral breast tumor relapses (IBTR) in patients treated with conservative surgery and radiation therapy (CS+RT) as either new primary tumors (NP) or true local recurrences (TR) and to assess the prognostic and therapeutic implications of this classification. Methods and Materials: Of the 1152 patients who have been treated at Yale-New Haven Hospital before 1990, 136 patients have experienced IBTR as their primary site of failure. These relapses were classified as either NP or TR. Specifically, patients were classified as NP if the recurrence was distinctly different from the primary tumor with respect to the histologic subtype, the recurrence location was in a different location, or if the flow cytometry changed from aneuploid to diploid. This information was determined by a detailed review of each patient's hospital and/or radiotherapy record, mammograms, and pathologic reports. Results: As of 2/99, with a mean follow-up of 14.2 years, the overall ipsilateral breast relapse-free rate for all 1152 patients was 86% at 10 years. Using the classification scheme outlined above, 60 patient relapses were classified as TR, 70 were classified as NP and 6 were unable to be classified. NP patients had a longer mean time to breast relapse than TR patients (7.3 years vs. 3.7 years, p < 0.0001) and were significantly younger than TR patients (48.9 years vs. 54.5 years, p < 0.01). Patients developed both TR and NP at similar rates until approximately 8 years, when TR rates stabilized but NP rates continued to rise. By 15 years following original diagnosis, the TR rate was 6.8% compared to 13.1% for NP. Of the patients who had been previously tested for BRCA1/2 mutations, 17% (8/52) had deleterious mutations. It is noteworthy that all patients with deleterious mutations had new primary IBTR, while patients without deleterious mutations had both TR and NP (p = 0.06). Ploidy was evenly distributed between TR and NP but NP

  8. Radiation proctitis. Clinical and pathological manifestations, therapy and prophylaxis of acute and late injurious effects of radiation on the rectal mucosa

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, F.B.; Feldmann, H.J. [Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie, Technische Universitaet Muenchen (Germany)

    1998-11-01

    Background: Often the rectum is the dose-limiting organ in curative radiation therapy of pelvic malignancies. It reacts with serous, mucoid, or more rarely bloody diarrhea. Methods: A research for reports on prophylactic and supportive therapies of radiation-induced proctitis was performed (Medline, Cancerlit, and others). Results: No proven effective prophylactic local or systemic therapies of radiation proctitis exist. Also, no reasonable causal medication is known. In the treatment of late radiation sequelae no clincally tested certain effective therapy exists, too. Antiinflammatory, steroidal or non-steroidal therapeutics as well as sucralfate can be used as topical measures. They will be successful in some patients. Side effects are rare and the therapy is cost-effective. Treatment failures can be treated by hyperbaric oxygen. This will achieve good clinical results in about 50% of the cases. Single or few mucosal telangiectasias with rectal bleeding can be treated sufficienctly by endoscopic cautherization. Conclusion: Besides clinical studies acute proctitis should be treated just symptomatically. Radical surgery should be performed only when all conventional treatments have been uneffective, although no certain effective therapies of radiation-induced late proctitis exist. (orig.) [Deutsch] Hintergrund: Oft ist der Enddarm das dosislimitierende Organ bei der kurativen Radiotherapie boesartiger Tumoren des Beckens. Er reagiert mit seroesen, mukoesen oder sehr selten blutig tingierten Durchfaellen. Methode: Es wurde eine Literaturrecherche nach prophylaktischen und supportiven Therapien der radiogenen Proktitis durchgefuehrt (Medline, Cancerlit und andere). Ergebnisse: Es existieren keine gesicherten effektiven prophylaktischen Therapie der radiogen Proktitis, weder lokal noch systemisch. Es sind auch keine sinnvollen kausalen Behandlungen bekannt. Auch in der Behandlung spaeter Strahlenfolgen existieren keine klinisch getesteten, sicher wirksamen

  9. Purely cutaneous sclerosing IgG4-related disease of the cephalic region: case report and a mini-review of the clinical and pathological aspects.

    Science.gov (United States)

    Muscardin, Luca; Paolino, Giovanni; Panetta, Chiara; Donati, Pietro

    2016-06-01

    IgG4-related disease is a recently defined emerging entity. Many different organs may be affected by this disease: pancreas, salivary and lacrimal glands, liver, peritoneum and lung. Also the skin may be affected, as secondary localization, while as primary cutaneous localization it has been rarely described. A male patient presented at our Institute with a two-year history of sclerosing erythematous nodules of the scalp. Histological examination showed a T-lymphocyte (CD3+) infiltrate with interspersed plasmacytoid cells and the interposition of a fibrosclerotic tissue. We found numerous IgG4+ cells at the periphery of the nodular structures, while the serum levels of IgG4 and the remaining blood chemistry analysis were normal. Only a few cases of primitive cutaneous pseudo-lymphomatous IgG4-related disease have been described in the literature. Our case showed the same clinical and histologic features of those previously described; the etiology of IgG4-related diseases remains to be elucidated. PMID:26340764

  10. A systematic review of the parenting and outcomes experienced by offspring of mothers with borderline personality pathology: Potential mechanisms and clinical implications.

    Science.gov (United States)

    Eyden, Julie; Winsper, Catherine; Wolke, Dieter; Broome, Matthew R; MacCallum, Fiona

    2016-07-01

    There is growing interest in whether the parenting strategies and offspring outcomes of mothers with borderline personality disorder (BPD) differ from those of mothers without BPD. We searched PsychINFO, PubMed, EMBASE, Web of Science, Scopus and ASSIA databases for studies examining parenting skills and attitudes among mothers with BPD/BPD symptoms and/or offspring outcomes. PRISMA reporting guidelines were followed. Of 10,067 abstracts screened, 101 full-text articles were retrieved and 33 met pre-determined criteria for qualitative synthesis. Overall, studies suggest that mothers with BPD/BPD symptoms are more likely to engage in maladaptive interactions with their offspring characterised by insensitive, overprotective, and hostile parenting compared to mothers without BPD/BPD symptoms. Adverse offspring outcomes include BPD symptoms, internalising (including depression) and externalising problems, insecure attachment patterns, and emotional dysregulation. Findings suggest that vulnerability from mother to offspring may be partly transmitted via maladaptive parenting and maternal emotional dysfunction. Conclusions were limited by study heterogeneity in methodology and construct definitions, as well as a paucity of clinical comparison groups. Prospective studies of mothers with BPD and their offspring from pregnancy onwards may further elucidate mechanisms of transmission and identify resilience factors across development. Parenting behaviour awareness, improving attachment behaviours and emotional regulation strategies may be important intervention targets. PMID:27261413

  11. The Effect of Electromagnetic Field Treatment on Recovery from Ischemic Stroke in a Rat Stroke Model: Clinical, Imaging, and Pathological Findings

    Directory of Open Access Journals (Sweden)

    Y. Segal

    2016-01-01

    Full Text Available Stroke is a leading cause of death and disability. Effects of stroke include significant deficits in sensory-motor skills and cognitive abilities. At present, there are limited effective interventions for postacute stroke patients. In this preliminary research we studied a new noninvasive, very low intensity, low frequency, electromagnetic field treatment (VLIFE, targeting a neural network, on an in vivo stroke rat model. Eighteen rats were divided into three groups: sham (M1 and two treatment groups which were exposed to VLIFE treatment for 4 weeks, one using theta waves (M2 and another using beta waves (M3; all groups were followed up for an additional month. Results indicate that the M2 and M3 treated groups showed recovery of sensorimotor functional deficits, as demonstrated by Modified Neurological Severity Score and forelimb placement tests. Brain MRI imaging results show a decrease in perilesional edema and lateral ventricle widening in the treated groups. Fiber tracts’ imaging, following VLIFE treatment, showed a higher white matter integrity compared to control. Histological findings support neural regeneration processes. Our data suggest that VLIFE treatment, targeting a specific functional neural network by frequency rather than location, promotes neuronal plasticity after stroke and, as a result, improves clinical recovery. Further studies will investigate the full potential of the treatment.

  12. The Effect of Electromagnetic Field Treatment on Recovery from Ischemic Stroke in a Rat Stroke Model: Clinical, Imaging, and Pathological Findings.

    Science.gov (United States)

    Segal, Y; Segal, L; Blumenfeld-Katzir, T; Sasson, E; Poliansky, V; Loeb, E; Levy, A; Alter, A; Bregman, N

    2016-01-01

    Stroke is a leading cause of death and disability. Effects of stroke include significant deficits in sensory-motor skills and cognitive abilities. At present, there are limited effective interventions for postacute stroke patients. In this preliminary research we studied a new noninvasive, very low intensity, low frequency, electromagnetic field treatment (VLIFE), targeting a neural network, on an in vivo stroke rat model. Eighteen rats were divided into three groups: sham (M1) and two treatment groups which were exposed to VLIFE treatment for 4 weeks, one using theta waves (M2) and another using beta waves (M3); all groups were followed up for an additional month. Results indicate that the M2 and M3 treated groups showed recovery of sensorimotor functional deficits, as demonstrated by Modified Neurological Severity Score and forelimb placement tests. Brain MRI imaging results show a decrease in perilesional edema and lateral ventricle widening in the treated groups. Fiber tracts' imaging, following VLIFE treatment, showed a higher white matter integrity compared to control. Histological findings support neural regeneration processes. Our data suggest that VLIFE treatment, targeting a specific functional neural network by frequency rather than location, promotes neuronal plasticity after stroke and, as a result, improves clinical recovery. Further studies will investigate the full potential of the treatment. PMID:26949561

  13. Preliminary clinical investigation of the contraceptive efficacy and chemical pathological effects of RICOM-1013-J of Ricinus communis var minor on women volunteers.

    Science.gov (United States)

    Isichei, C O; Das, S C; Ogunkeye, O O; Okwuasaba, F K; Uguru, V E; Onoruvwe, O; Olayinka, A O; Dafur, S J; Ekwere, E O; Parry, O

    2000-02-01

    The seeds of Ricinus communis Linn, RICOM-1013-J, administered as a single oral dose of 2.3-2.5 g once per 12 months protected against pregnancy in 50 women volunteers for a period of one year. The antifertility and contraceptive efficacy of the seed was demonstrated in this study. Clinical observation revealed very minimal side effects. Some of the side effects investigated included headache, nausea, vomiting, weight gain, loss of appetite, raised blood pressure and dysmenorrhoea. Furthermore, both the renal and liver functions were not affected as revealed by urea, electrolyte and creatinine values as well as total bilirubin, conjugated bilirubin, serum albumin, total protein and transaminases values when compared with control values. In addition cholesterol and phospholipids were not significantly altered. When all these results are considered together, it seems unlikely that the antifertility and contraceptive efficacy of RICOM-1013-J is due to hormonal mechanisms alone since side effects, renal and liver function, and cholesterol effects attributable to oestrogen and/or progesterone were minimal in the volunteers. PMID:10641046

  14. Clowns Benefit Children Hospitalized for Respiratory Pathologies

    OpenAIRE

    Giuseppe Curcio; Elena Isola; Giuseppe Paolone; Mario Bertini

    2011-01-01

    The study aims at evaluating health-generating function of humor therapy in a hospital ward hosting children suffering from respiratory pathologies. The main scope of this study is to investigate possible positive effects of the presence of a clown on both the clinical evolution of the on-going disease, and on some physiological and pain parameters. Forty-three children with respiratory pathologies participated in the study: 21 of them belonged to the experimental group (EG) and 22 children t...

  15. Congenital pseudarthrosis of clavicle, differential diagnosis pathology

    International Nuclear Information System (INIS)

    The congenital pseudarthrosis of clavicle is a rare entity, frequently appearing without association to other pathologies and does not cause important limitations in the children. It can confuse with other traumatic pathologies like clavicle fracture. Most of the patients complain about the aesthetics and few times for pain. The treatment is generally surgical there is controversy about of carrying out surgery. We reported two clinical cases with pseudoarthrosis of the right clavicle that they received surgical treatment with satisfactory results.

  16. Clinical pathological analysis on muscle of Duchenne progressive muscular dystrophy%假肥大型进行性肌营养不良症肌肉的临床病理分析

    Institute of Scientific and Technical Information of China (English)

    党秋红; 李剑峰; 曾宪旭; 邵峥; 关侠

    2011-01-01

    目的 探讨假肥大型进行性肌营养不良症的临床病理特征,提高对本病的认识.方法 回顾性分析进行性肌营养不良症患儿20例的临床资料,包括病史、临床症状、CT,MRI检查结果、病理结果.结果 早期镜下见肌纤维粗细不等,见有不同程度的肥大,肿胀,变圆形,部分肌核不在边缘,内移至胞核内,肌纤维间有不同程度的脂肪细胞及纤维组织浸润,少许肌纤维伴有萎缩及变性.结论 目前尚未找到一种可逆转本病病程的特效疗法.故应强调采取有效的措施降低本病在人群中的遗传负荷,减少本病的发生.%Objective To improve the understanding of Duchenne progressive muscular dystrophy (DPMD),their clinical and pathological features were investigated. Methods Clinical data of twenty children with DPMD,which include history,clinical symptoms,CT,MRI findings and pathology results, were analyzed retrospectively. Results Microscopically, some muscle fibers shown hypertrophy, swelling, roundy with different degrees of swelling,turn round,part of the muscle nuclei do not on the edge. Some fat cells and fibrous tissue were infiltrated within the muscle fibers, and a few muscle fibers shown atrophy and degeneration. Conclusions There is no an effective way to reverse the disease. Therefore, emphasis should be placed to take effective measures to reduce genetic load of the disease in the population and reduce its incidence.

  17. Radioisotope studies under pathologic conditions

    International Nuclear Information System (INIS)

    This article presents a general discussion on salivary pathology, before dealing with the various salivary gland diseases which can draw real advantage from radioisotope studies. Clinical problems related to the salivary glands first concern diffuse or focal glandular swelling. Focal swelling includes inflammatory or metastatic deposits in preauricular or submandibular lymph nodes, cysts, abscesses, foci of inflammation, benign and malignant neoplasms of the salivary glands themselves or of surrounding blood or lymph vessels, nerves, connective tissue, and oral mucosa. Primary tumors of the salivary glands are rare and usually benign. The combination of a systemic disease with dry mouth and dry eyes due to inflamed conjunctiva and cornea because of decreased fluid production, forms Sjogren syndrome. It may also cause diffuse glandular swelling. Chronic alcoholism, cirrhosis, diabetes mellitus, hyperlipoproteinemia, and malnutrition are other pathologic conditions sometimes associated with diffuse salivary gland swelling

  18. 牙龈腺泡细胞癌1例报告及文献复习%Clinical and pathological characteristics of acinic cell carcinoma of gingiva:A case report and review of literature

    Institute of Scientific and Technical Information of China (English)

    朱王勇; 陶谦

    2014-01-01

    本文报告了1例发生于右上颌牙龈的腺泡细胞癌病例,并回顾相关文献,总结口腔颌面部异位腺泡细胞癌的临床及病理特点。口腔颌面部异位腺泡细胞癌生长缓慢,或有疼痛、神经麻木,治疗以手术为首选,复发和转移率不高,必要时辅以放化疗。%To summarize the clinical and pathological characteristics of heterotopic acinic cell carcinoma of oromaxillo-facial region.A case of acinic cell carcinoma of gingiva was reported and the relevant literatures were reviewed and analyzed.The heterotopic acinic cell carcinoma grows slowly.Clinical symptom is pain or numbness.Surgery is the main means of treatment.Radiotherapy or chemotherapy is added after operation if necessary.The recurrence rate is low and malignant transformation is rare.

  19. 原发中枢神经系统弥漫大B细胞淋巴瘤临床病理观察%Clinical pathology observation of primary central nervous system diffuse large B cell lymphoma

    Institute of Scientific and Technical Information of China (English)

    王永峰; 张红鸽; 高恒瑞

    2014-01-01

    Objective:To explore the clinical pathological features,diagnosis and differential diagnosis of primary central nervous system diffuse large B cell lymphoma.Methods:The clinical data,histological pathological morphology and immunohistochemical results of 12 patients with primary central nervous system diffuse large B cell lymphoma were retrospectively analyzed.Results:The average age of 12 patients was 53.2 years.Visible tumor cells showed diffuse invasive distribution under light microscope, there was no boundaries with brain tissue,tumor cells in certain areas aggregated around vessel with raglan sleeves structure. There were infiltration and destruction of vascular wall.Immunohistochemistry showed that 12 cases of CD20,CD79,PAX5 and BCL-6 were positive,Ki-67 proliferation index was 40%~90%;CD3,CD10,Mum-1,GFAP,S-100 and CKpn were all negative. Conclusion:The incidence rate of primary central nervous system diffuse large B cell lymphoma is low.It has no clinical specificity. Its malignancy degree is high.Correctly grasping the clinical pathological and immunohistochemical features have important significance to the diagnosis of the disease.%目的:探讨原发中枢神经系统弥漫大B细胞淋巴瘤临床病理特征、诊断与鉴别诊断。方法:回顾性分析12例原发中枢神经系统弥漫大B细胞淋巴瘤患者临床资料、组织学病理形态及免疫组化结果。结果:12例患者平均年龄53.2岁,光镜下可见肿瘤细胞呈弥漫浸润性分布,与脑组织无明显分界,某些区域肿瘤细胞聚集在血管周围,呈袖套样结构,浸润和破坏血管壁。免疫组化示12例CD20、CD79а、PAX5和BCL-6均弥漫阳性,Ki-67增殖指数40%~90%;CD3、CD10、Mum-1、GFAP、S-100和CKpn均阴性。结论:原发中枢神经系统弥漫大B细胞淋巴瘤发病率低,临床无特异性,恶性程度高,正确掌握临床病理与免疫组化特征对该病的诊断具有重要意义。

  20. 老年人皮肤基底细胞癌的临床与病理特征研究%Clinical and pathology characteristic of skin basal cell carcinoma in the aged

    Institute of Scientific and Technical Information of China (English)

    倪通; 黄方; 吴波

    2012-01-01

    目的 研究老年人皮肤基底细胞癌的临床及病理特征,提高对本病的认识及诊治水平. 方法 对174例老年人皮肤基底细胞癌病例临床特征、组织病理、误诊情况、治疗方法及预后等进行综合分析. 结果 本组患者病程长,平均(5±1.8)年,无明显发病诱因.头面部好发56.32%,多为单发(92.53%).临床表现以结节溃疡型93例(17.57%)、色素型31例(41.89%)、浅表型17例(22.97%)多见;病理分型以混合型63例(36.21%)、结节型42例(24.14%),浅表型37例(21.26%)多见.误诊64例(占36.78%),以混合色素型误诊最多;手术治疗效果好,预后佳. 结论 老年人基底细胞癌好发于头面部,其临床表现和组织病理学特征明显,手术治疗预后良好.%Objective To research clinical and pathology characteristics of skin basal cell carcinoma in the aged to improve recognitions and diagnosis of this disease. Methods Clinical features, tissue pathology,diagnostic errors, therapies and prognosis of 174 aged cases who undered skin basal cell carcinoma were analyzed. Results The course of disease was long, and the average time was 5 ± 1. 8 years. The inducements of them were not obvious. The skin lesion was most commom on head and face, 56. 32% , was single. Clinical manifestation of nodule and ulcer 93(17. 57% ) , pigment 31(41.89%), superficial 17 (22. 97% ) were common. Pathologyformas of mixde type 63 (36. 21 % ) , nodular type 42 (24. 14% ) and superficial type 37(21. 26% ) were commom. Misdiagnosis rate was 36. 78 percent, most was mixed pig-mented type, surgical treatment was preety goog, patients have good prognosis. Conclusions Skin basal cell carcinoma in advanced age always occurred on head and face, clinical manifestation and pathology characteristic of it were variety. Surgical treatment have good prognosis.

  1. Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy

    International Nuclear Information System (INIS)

    Cellular mesoblastic nephroma has been associated with a more aggressive course than classic mesoblastic nephroma, including local recurrences and metastases. To define the clinicopathologic and imaging features distinguishing cellular from classic mesoblastic nephroma. Retrospective review of clinical charts and imaging studies of ten children with mesoblastic nephroma from 1996 to 2007 at a large children's hospital. In six children the mesoblastic nephroma was pure cellular, in two mixed, and in two classic. The mean ages at diagnosis were 107 days for those with the cellular form, and 32 days for those with the classic form. Hypoechoic or low-attenuation regions representing necrosis or hemorrhage were found in all children with the cellular form and in none of those with the classic form. Hypertension was present in 70% and hypercalcemia in 20% of the children and resolved following nephrectomy. Two cellular tumors encased major abdominal vessels. Local recurrence and metastases occurred within 6 months of tumor resection in two children with the cellular form. Intraspinal extension and intratumoral pseudoaneurysm were seen in one child with the cellular form. The cellular tumors shared histopathologic features with infantile fibrosarcoma (IFS), and RT-PCR testing in two children with the cellular form revealed the t(12;15) ETV6-NTRK3 gene fusion common to IFS. Distinct from the classic form, cellular mesoblastic nephroma is more heterogeneous in appearance on imaging, tends to be larger and present later in infancy, and can exhibit aggressive behavior including vascular encasement and metastasis. Intraspinal extension and intratumoral pseudoaneurysm are previously unreported findings encountered in our cellular mesoblastic nephroma series. The shared histopathology and translocation gene fusion support the concept of cellular mesoblastic nephroma as the renal form of IFS. (orig.)

  2. Distribution of cagG gene in Helicobacter pylori isolates from Chinese patients with different gastroduodenal diseases and its clinical and pathological significance

    Institute of Scientific and Technical Information of China (English)

    Can Xu; Zhao-Shen Li; Zhen-Xing Tu; Guo-Ming Xu; Yan-Fang Gong; Xiao-Hua Man

    2003-01-01

    AIM: To determine the distribution of cagG gene of Helicobacter pylori(Hpylori) isolates cultured from patients with various digestive diseases and its relationship with gastroduodenal diseases.METHODS: cagG was amplified by polymerase chain reaction in 145 H pylori isolates cultured from patients with chronic gastritis (n=72), duodenal ulcer (n=48), gastric ulcer (n=17), or gastric and duodenal ulcer (n=8), and the relationship between cagGstatus and the grade of gastric mucosal inflammation was determined.RESULTS: cagG was present in 91.7% of the 145 H pylori isolates, with the rates were 90.3%, 93.8%, 88.2% and 100.0%, respectively, in those from patients with chronic gastritis, duodenal ulcer, gastric ulcer, and gastric and duodenal ulcer. There was no significant difference among the four groups (P>0.05). The average grade of gastric mucosal inflammation in the antrum and corpus was 1.819±0.325and 1.768±0.312, respectively in cagG positive patients,whereas the average inflammation grade was 1.649±0.297,1.598±0.278 respectively in cagG negative cases (P>0.05).CONCLUSION: cagG gene of H pylori was quite conservative,and most H pylori strains in Chinese patients were cagG positive.cagG status was not related to clinical outcome or the degree of gastric mucosal inflammation. Therefore, cagG can notbe used as a single marker for discrimination of H pylori strains with respect to a specific digestive disease.

  3. (18)F-FDG PET/CT in the early prediction of pathological response in aggressive subtypes of breast cancer: review of the literature and recommendations for use in clinical trials.

    Science.gov (United States)

    Groheux, David; Mankoff, David; Espié, Marc; Hindié, Elif

    2016-05-01

    Early assessment of response to neoadjuvant chemotherapy (NAC) might be helpful in avoiding the toxicity of ineffective chemotherapy and allowing refinement of treatment. We conducted a review of the literature regarding the applicability of (18)F-FDG PET/CT to the prediction of an early pathological response in different subgroups of breast cancer. Clinical research in this field has intensified in the last few years. Early studies by various groups have shown the potential of (18)F-FDG PET/CT in the early assessment of response to NAC. However, interim PET/CT in breast cancer has not yet gained wide acceptance compared to its use in other settings such as lymphomas. This is in part due to a lack of consensus that early evaluation of response can be used to direct change in therapy in the neoadjuvant breast cancer setting, and only limited data showing that response-adaptive therapy leads to improved outcomes. However, one major element that has hampered the use of (18)F-FDG PET/CT in directing neoadjuvant therapy is its evaluation in populations with mixed subtypes of breast cancer. However, major improvements have occurred in recent years. Pilot studies have highlighted the need for considering breast cancer subtype and the type of treatment, and have offered criteria for the use of PET/CT for the early prediction of response in specific settings. (18)F-FDG PET/CT has considerable potential for the early prediction of pathological complete response to NAC in aggressive subtypes such as triple-negative or HER2-positive breast cancers. The results of a multicentre trial that used early metabolic response on (18)F-FDG PET/CT as a means to select poor responders to adapt neoadjuvant treatment have recently been published. Other trials are ongoing or being planned. PMID:26758726

  4. {sup 18}F-FDG PET/CT in the early prediction of pathological response in aggressive subtypes of breast cancer: review of the literature and recommendations for use in clinical trials

    Energy Technology Data Exchange (ETDEWEB)

    Groheux, David [Saint-Louis Hospital, Department of Nuclear Medicine, Paris Cedex 10 (France); INSERM/CNRS UMR944/7212, University Paris-Diderot, PRES Paris Cite, Paris (France); Mankoff, David [University of Pennsylvania Perelman School of Medicine, Department of Radiology, Philadelphia (United States); Espie, Marc [INSERM/CNRS UMR944/7212, University Paris-Diderot, PRES Paris Cite, Paris (France); Saint-Louis Hospital, Department of Medical Oncology, Breast Diseases Centre, Paris (France); Hindie, Elif [University of Bordeaux, Department of Nuclear Medicine, Haut-Leveque Hospital, Bordeaux (France)

    2016-05-15

    Early assessment of response to neoadjuvant chemotherapy (NAC) might be helpful in avoiding the toxicity of ineffective chemotherapy and allowing refinement of treatment. We conducted a review of the literature regarding the applicability of {sup 18}F-FDG PET/CT to the prediction of an early pathological response in different subgroups of breast cancer. Clinical research in this field has intensified in the last few years. Early studies by various groups have shown the potential of {sup 18}F-FDG PET/CT in the early assessment of response to NAC. However, interim PET/CT in breast cancer has not yet gained wide acceptance compared to its use in other settings such as lymphomas. This is in part due to a lack of consensus that early evaluation of response can be used to direct change in therapy in the neoadjuvant breast cancer setting, and only limited data showing that response-adaptive therapy leads to improved outcomes. However, one major element that has hampered the use of {sup 18}F-FDG PET/CT in directing neoadjuvant therapy is its evaluation in populations with mixed subtypes of breast cancer. However, major improvements have occurred in recent years. Pilot studies have highlighted the need for considering breast cancer subtype and the type of treatment, and have offered criteria for the use of PET/CT for the early prediction of response in specific settings. {sup 18}F-FDG PET/CT has considerable potential for the early prediction of pathological complete response to NAC in aggressive subtypes such as triple-negative or HER2-positive breast cancers. The results of a multicentre trial that used early metabolic response on {sup 18}F-FDG PET/CT as a means to select poor responders to adapt neoadjuvant treatment have recently been published. Other trials are ongoing or being planned. (orig.)

  5. 18F-FDG PET/CT in the early prediction of pathological response in aggressive subtypes of breast cancer: review of the literature and recommendations for use in clinical trials

    International Nuclear Information System (INIS)

    Early assessment of response to neoadjuvant chemotherapy (NAC) might be helpful in avoiding the toxicity of ineffective chemotherapy and allowing refinement of treatment. We conducted a review of the literature regarding the applicability of 18F-FDG PET/CT to the prediction of an early pathological response in different subgroups of breast cancer. Clinical research in this field has intensified in the last few years. Early studies by various groups have shown the potential of 18F-FDG PET/CT in the early assessment of response to NAC. However, interim PET/CT in breast cancer has not yet gained wide acceptance compared to its use in other settings such as lymphomas. This is in part due to a lack of consensus that early evaluation of response can be used to direct change in therapy in the neoadjuvant breast cancer setting, and only limited data showing that response-adaptive therapy leads to improved outcomes. However, one major element that has hampered the use of 18F-FDG PET/CT in directing neoadjuvant therapy is its evaluation in populations with mixed subtypes of breast cancer. However, major improvements have occurred in recent years. Pilot studies have highlighted the need for considering breast cancer subtype and the type of treatment, and have offered criteria for the use of PET/CT for the early prediction of response in specific settings. 18F-FDG PET/CT has considerable potential for the early prediction of pathological complete response to NAC in aggressive subtypes such as triple-negative or HER2-positive breast cancers. The results of a multicentre trial that used early metabolic response on 18F-FDG PET/CT as a means to select poor responders to adapt neoadjuvant treatment have recently been published. Other trials are ongoing or being planned. (orig.)

  6. Skeletal lesions in the broiler, with special reference to dyschondroplasia (osteochondrosis). Pathology, frequency and clinical significance in two strains of birds on high and low energy feed.

    Science.gov (United States)

    Poulos, P W; Reiland, S; Elwinger, K; Olsson, S E

    1978-01-01

    The material consisted of 2,950 broilers of the variety Hybro Compact of two lines. An equal number of birds of both lines were given either a high energy feed (H) or a low energy feed (L), containing all nutrients known to be required by broilers. During the first 3 weeks, H and L starter feeds were given and thereafter H and L finishing feeds. At 21, 35, and 45 days of age, the birds were weighed in groups, and feed conversion calculated. At 21 days of age, the frequency of crooked toes and swollen hocks was registered. Birds were taken from each group for necropsy at regular intervals. Both clinically normal birds and those with locomotor disturbances were selected for necropsy, including radiographic examination. With the exception of 240 birds, which were kept for a long-term study, the birds on the H feed were slaughtered at 42 days of age and the ones on the L feed at 49 days of age. The long-term birds were slaughtered at regular intervals, weighed, and necropsied. The last birds were slaughtered at 134 days of age. A large number of skeletal lesions were found. They were: Twisted legs, slipped tendons, crooked toes, bowing of the proximal tibia, dyschondroplasia at different sites, fracture of the fibula, deformity of the spine, deviated sternum (with breast blisters), arthritis, and osteomyelitis. Leg weakness was found to be almost synonymous with skeletal deformities. Other causes were rare. The normal development and morphology of the skeleton and the morphology of tibial dyschondroplasia were the same as those previously described in the turkey. Dyschondroplasia was found not only in the proximal tibia but also in the distal tibia, proximal tarsometatarsus, proximal and distal femur, and to some extent also in the costochondral junction. Tibial dyschondroplasia was more common in the birds on the H feed than in the birds on the L feed. Hence, tibial dyschondroplasia was correlated with rapid growth. The other skeletal lesions did not differ in

  7. Initial Construction and Validation of the Pathological Narcissism Inventory

    Science.gov (United States)

    Pincus, Aaron L.; Ansell, Emily B.; Pimentel, Claudia A.; Cain, Nicole M.; Wright, Aidan G. C.; Levy, Kenneth N.

    2009-01-01

    The construct of narcissism is inconsistently defined across clinical theory, social-personality psychology, and psychiatric diagnosis. Two problems were identified that impede integration of research and clinical findings regarding narcissistic personality pathology: (a) ambiguity regarding the assessment of pathological narcissism vs. normal…

  8. Facilitating Research in Pathology using Natural Language Processing

    OpenAIRE

    Xu, Hua; Friedman, Carol

    2003-01-01

    Clinical research projects frequently rely on manual extraction of information from pathology reports, which is a costly and time-consuming process. This paper describes use of a natural language processing (NLP) system to automatically extract and structure information in textual pathology reports that is needed for clinical research.

  9. Expression of hedgehog signal molecules in pancreatic cancer and their correlation with clinical and pathologic characteristics%Hedgehog信号蛋白在胰腺癌中的表达及临床意义

    Institute of Scientific and Technical Information of China (English)

    田孝东; 杨尹默; 汤坚强; 万远廉; 黄莛庭

    2008-01-01

    目的 研究Hedgehog相关信号蛋白Ihh、Ptc和Smo在胰腺癌中的表达情况及其临床意义.方法 采用免疫组织化学方法 检测54例原发性胰腺癌及5例正常胰腺石蜡标本中Hedgehog信号蛋白(Ihh、Ptc、Smo)的表达情况,并统计分析其阳性率与临床病理特征的相关性;采用Westernblot比较21例新鲜胰腺癌及癌旁胰腺组织标本Hedgehog信号蛋白表达量的差异.结果 54例胰腺癌标本中,Ihh、Ptc及Smo阳性率分别为70.4%、64.8%和88.9%,5例正常胰腺组织中均无阳性表达;Ptc阳性率与肿瘤大小、分化程度、淋巴结转移情况及肿瘤TNM分期显著相关,Smo表达率则与肿瘤分化程度显著相关(P<0.05);21例新鲜胰腺癌标本中Ihh、Ptc、Smo平均表达量均显著高于癌旁胰腺组织(P<0.05).结论 胰腺癌组织中Hedgehog信号蛋白表达量显著增加;Hedgehog信号蛋白与胰腺癌临床病理特征相关.%Objective To investigate the expression of hedgehog signal molecules (Ihh,Ptc and Stop) in human pancreatic cancer and their correlation with clinical and pathologic characteristics.Methods Fifty-four pancreatic cancer samples and 5 normal pancreatic tissues were examined by im-munohistochemistry for the expression and localization of hedgehog signal molecules (Ihh, Ptc andStop). Meanwhile,correlation of hedgehog signal molecules to clinical and pathologic characteristics ofpancreatic cancer was analyzed. Western blot was carried out to analyze the expression of Ihh,Ptc and Smo in 21 freshly removed pancreatic cancer tissues and paraneoplastic pancreatic tissues. Results Of the 54 pancreatic cancer samples, immunoreactivity of Ihh, Ptc and Smo was observed in 70. 4%,64.8% and 88.9 % of the cancer tissues, respectively. No immunoreaetivity was observed in the ductal cells of all the 5 normal pancreas tissues. Expression of Ptc was strongly correlated with tumor size,differentiation grade of tumor cells,lymph node metastasis and TNM stage of tumor

  10. 口腔颌面部结节性筋膜炎临床病理分析%Clinical and Pathological Analysis of Nodular Fasciitis in Oral and Maxillofacial Region

    Institute of Scientific and Technical Information of China (English)

    李海如

    2015-01-01

    目的探讨结节性筋膜炎的临床及病理学特征及其鉴别诊断。方法对23例口腔颌面部结节性筋膜炎临床和病理资料进行复习,重新确诊。结果结节性筋膜炎表现为生长迅速,肿块小,质硬边界不清软组织肿块。光镜特点疏松的粘液样基质中有丰富的增生活>肥胖的梭形细胞,核分裂像多见,胆病理性核分裂罕见,低倍镜下呈疏密相间的“区带现象”,可呈席纹状,束状,半旋涡状或“S”形排列,基质内有小裂隙及微囊样形成呈网眼状结构,病灶边缘有新生毛细血管和炎细胞集中,红细胞外渗。结论结节性筋膜炎诊断应紧密结合其临床病史中生长快的特点,显微镜下注意观察5个组织学特征,因病理形态呈多态性,故易误诊为恶性软组织肉瘤。%Objective To explore the clinical and pathological features of nodular fasci tis and its dif erential diagnosis.Methods To review the 23 cases of oral and maxil ofacial nodular fasci tis:clinical and pathological data,re diagnosed.Results Nodular fasci tis showed rapid growth,mass of smal ,hard boundary is not clear soft tissue mass.A spindle cel rich hyperplastic obesity myxoid matrix light characteristics of osteoporosis,mitosis was common,bilious rational rare mitotic figures,at low magnification is spacing"zone phenomenon",can be in a storiform,fasciculate,semi spiral or"S"shaped ar angement,mucus like matrix loose feathery structure or tissue culture like growth,longer course,cicatricial col agen formation,stroma with smal cracks and microcystic form a mesh like structure,lesion edge newborn capil aries and inflammatory cel concentration,erythrocyte extravasation.Conclusion The diagnosis of nodular fasci tis should be closely combined with the characteristic of the clinical history in fast growth,pay at ention to characteristics of 5 tissue under the microscope observation,due to pathological morphology are polymorphic

  11. Pathology informatics fellowship training: Focus on molecular pathology

    OpenAIRE

    Diana Mandelker; Lee, Roy E.; Platt, Mia Y.; Gregory Riedlinger; Andrew Quinn; Luigi K F Rao; Klepeis, Veronica E.; Michael Mahowald; Lane, William J; Beckwith, Bruce A; Baron, Jason M.; David S McClintock; Kuo, Frank C.; Lebo, Matthew S.; Gilbertson, John R.

    2014-01-01

    Background: Pathology informatics is both emerging as a distinct subspecialty and simultaneously becoming deeply integrated within the breadth of pathology practice. As specialists, pathology informaticians need a broad skill set, including aptitude with information fundamentals, information systems, workflow and process, and governance and management. Currently, many of those seeking training in pathology informatics additionally choose training in a second subspecialty. Combining pathology ...

  12. 椎管内硬膜外血管脂肪瘤MRI表现及临床病理对照观察%Comparative analysis of MRI findings and clinical pathology for spine epidural angiolipomas

    Institute of Scientific and Technical Information of China (English)

    何东; 陈兴灿; 康宏厚; 王金泉; 毛佳伟; 岳承红

    2012-01-01

    Objectives: To investigate the MRI features of spine epidural angioliomas and its association with clinical pathology. Methods: Clinical data and MRI findings of 2 patients with spine epidural angioliomas were analyzed retrospectively. The correlations between image findings and pathological results including cellular component, heteromorphism and immunohistochemical consequence were evaluated. Results: Angiolipomas were composed of tenuity vascular and mature adipocyte, which located in spine epidural and showed dumbbell-shaped, and adjacent intervertebral foramen were evidenced enlarged. Compared with other tumors sited in spine epidural such as liparomphalus, the ratio of blood vessel and fat determined the MRI signals: isoin-tense or hyperintense signals on T1WI, hyperintense signals on T2WI. The tumors' signals increased or decreased on STIR, while increased in enhanced MRI. Conclusions: The size, morphology, MRI signal of angiolipomas and the association with the adjacent structure can be clearly displayed on MRI. STIR and enhanced MRI are valuable for distinguishing from other disorders.%目的:探讨椎管内硬膜外血管脂肪瘤的MRI特点,并观察MRI表现与病理特点之间的对应关系.方法:回顾性分析2例椎管内硬膜外血管脂肪瘤患者的临床资料、MRI信号和形态特点,并与临床病理学(含细胞组成、异型性和免疫组化结果)对照.结果:血管脂肪瘤病理学上由纤细的血管和成熟的脂肪细胞两部分组成,肿瘤位于椎管内硬膜囊后方呈哑铃型,邻近椎间孔扩大,MRI信号由血管和脂肪所含比例决定,与脂肪瘤等其他椎管内硬膜外肿瘤相比,血管脂肪瘤T1WI为等或高信号,T2WI为高信号,脂肪抑制像序列信号增高或减低,增强扫描病灶有强化.结论:MRI能清楚显示血管脂肪瘤的大小、形态、信号特征及其与椎管邻近结构的关系,脂肪抑制序列及增强扫描具有较高的诊断价值.

  13. 儿童非霍奇金淋巴瘤195例临床病理分析%Clinical pathologic study of 195 cases of childhood non-Hodgkin s lymphoma

    Institute of Scientific and Technical Information of China (English)

    王佳; 奚政君; 李稻

    2011-01-01

    Objective To evaluate the clinical and pathological features of childhood non-Hodgkin's lymphoma (NHL). Methods A total of 195 NHL cases, with age younger than twelve years old, diagnosed from January 1982 to January 2010 in Xinhua Hospital were reviewed. Results The peak onset age is 6 - 8 years old. The male to female ratio is 2.3 : 1 and male patients predominate in each subtype. The cases in stage III and IV account for 49.2%. The most common subtypes were lymphoblastic lymphoma (LBL) , Burkitt lymphoma (BL) and anaplastic large cell lymphoma (ALCL). About 88.8% cases of LBL is T-cell lymphoma while all the BL is B-cell lymphoma and all the ALCL is T-cell lymphoma. More than 1/3 (37.9%) of all the cases have primary extranodal lymphoma. More than one organ involvement was found in 56.1% of LBL cases when they were diagnosed. Conclusions Childhood NHL differs greatly from adult NHL in clinical and pathological aspects. Immunohistochemistry plays an important role in diagnosis.%目的 探讨儿童非霍奇金淋巴瘤(NHL)的临床病理特点.方法 收集1982年1月-2010年1月诊断的非霍奇金淋巴瘤病例195例,进行临床和病理分析.结果 儿童NHL发病年龄高峰在6~8岁,男女之比为2.3:1,III期和IV期占49.2%.病理组织类型主要有淋巴母细胞性淋巴瘤(LBL)、Burkitt淋巴瘤(BL)、间变性大细胞性淋巴瘤(ALCL);88.8%LBL为T细胞性淋巴瘤,BL皆为B细胞性淋巴瘤,ALCL皆为T细胞性淋巴瘤.37.9%病例首发于淋巴结外组织,56.1%LBL患儿确诊时已累及1个以上部位.结论 儿童NHL的临床及病理表现与成人NHL存在很大差异.免疫组化等技术对NHL的病理诊断有重要作用.

  14. Podocyte Pathology and Nephropathy

    Directory of Open Access Journals (Sweden)

    Sandra eMerscher

    2014-07-01

    Full Text Available Sphingolipids are components of the lipid rafts in plasma membranes, which are important for proper function of podocytes, a key element of the glomerular filtration barrier. Research revealed an essential role of sphingolipids and sphingolipid metabolites in glomerular disorders of genetic and non-genetic origin. The discovery that glucocerebrosides accumulate in Gaucher disease in glomerular cells and are associated with clinical proteinuria initiated intensive research into the function of other sphingolipids in glomerular disorders. The accumulation of sphingolipids in other genetic diseases including Tay-Sachs, Sandhoff, Fabry, hereditary inclusion body myopathy 2, Niemann-Pick and nephrotic syndrome of the Finnish type and its implications with respect to glomerular pathology will be discussed. Similarily, sphingolipid accumulation occurs in glomerular diseases of non-genetic origin including diabetic kidney disease (DKD, HIV-associated nephropathy, focal segmental glomerulosclerosis (FSGS and lupus nephritis. Sphingomyelin metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate have also gained tremendous interest. We recently described that sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b is expressed in podocytes where it modulates acid sphingomyelinase (ASMase activity and acts as a master modulator of danger signaling. Decreased SMPDL3b expression in post-reperfusion kidney biopsies from transplant recipients with idiopathic FSGS correlates with the recurrence of proteinuria in patients and in experimental models of xenotransplantation. Increased SMPDL3b expression is associated with DKD. The consequences of differential SMPDL3b expression in podocytes in these diseases with respect to their pathogenesis will be discussed. Finally, the role of sphingolipids in the formation of lipid rafts in podocytes and their contribution to the maintenance of a functional slit diaphragm in the glomerulus will be discussed.

  15. Pathological fractures in children: Diagnosis and treatment options.

    Science.gov (United States)

    Canavese, F; Samba, A; Rousset, M

    2016-02-01

    A fracture is defined as pathological when it arises in a bone tissue that has been modified and reshaped by a local or systemic pathological process. In children, pathological fractures can be secondary to several conditions, ranging from metabolic diseases to tumors, infections or neuromuscular pathologies. History, clinical examination and radiologic assessment are essential to making a diagnosis, to identifying the underlying cause and to planning the right treatment of a pathological fracture. Treatment must be tailored to both the fracture and the underlying cause. The objective of this work is to present the diagnostic approach and the course to follow when a child presents with a pathological fracture. The most common causes of pathological fractures, as well as their characteristics, will be described. Pathological fractures occurring in osteogenesis imperfecta and in abused children as well as stress fractures will not be discussed. PMID:26774903

  16. 肾脏黏液性管状和梭形细胞癌4例报告%Clinical and pathological characteristics of renal mucinous tubular and spindle cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    王俊生; 林云华; 商建峰; 勇强; 姜永光

    2011-01-01

    目的 探讨肾脏黏液性管状和梭形细胞癌的临床病理特征.方法 回顾分析4例肾脏黏液性管状和梭形细胞癌患者的临床资料.女性3例,男性1例;年龄35~56岁,平均41岁;左肾2例,右肾2例;肾上极3例,肾下极1例;肿瘤直径3.5~6.5cm,平均5.5cm;无明显临床症状及体征,均为体检发现.B超检查提示,2例肾囊实性占位,为良性肿瘤;2例为厚壁型肾囊肿.CT检查提示,3例肾囊实性占位,为良性肿瘤;1例为厚壁型肾囊肿.2例行MRI检查提示,肾脏囊实性占位,为良性肿瘤.结果 4例患者均予手术治疗,术中发现肿块与肾组织的界限清楚,易分离;肿块呈囊实性,囊壁厚薄均匀,组织致密且内壁光滑.术后病理组织学检查示:2例为低度恶性上皮细胞肿瘤,1例为恶性肿瘤(透明细胞癌不排除),另1例为肾脏黏液性管状和梭形细胞癌.结论 肾脏黏液性管状和梭形细胞癌是一种具有良性肿瘤生长特性的低度恶性倾向的肿瘤.%Objective To explore the clinical and pathological characteristics of renal mucinous tubular and spindle cell carcinoma. Methods Clinical data of 4 patients including 3 female and 1 male aged from 35 to 56 were analyzed retrospectively. Among the 4 cases, two tumors were in the left side and two in right. Three tumors located in the upper part of kidneys, one in the lower part. The size of tumors ranged from 3.5 to 6.5 cm. There was no obvious symptom or physical sign in all cases and the tumors were detected during healthy examination. In B type untrasonography, two patients showed cystsolid tumor and two showed thick-wall cyst of kidney. In CT scan, three patients showed cystsolid tumor and one showed thick-wall cyst of kidney. In MRI scan, two patients showed cystsolid tumor. All the imaging examinations indicated the lump was benign. Results There were clear boundaries between the tumors and normal kidney tissue and the lesions were easy to be separated

  17. 垂体微腺瘤的临床内分泌与病理免疫组化类型相关性研究%Micro pituitary adenomas clinical endocrine correlation with pathologic types of immunohistochemical study

    Institute of Scientific and Technical Information of China (English)

    禹亚丽

    2014-01-01

    目的:对垂体微腺瘤的临床症状体征、内分泌与病理免疫组化类型相关性进行探讨。方法选取2010年1月至2012年12月在本院确诊的垂体微腺瘤患者84例,对其进行内分泌、影像学和病理检查,分析检查结果之间的关系。结果患者出现内分泌症状76例(90.47%),免疫组化阳性组内分泌症状发生率[92.59%(75/81)]较免疫组化阴性组[33.33%(1/3)]高,差异具有显著性(χ2=5.92,P<0.05),表明内分泌症状与免疫组化结果相符。血清泌乳素(PRL)阳性组血清PRL增高及闭经、溢乳或月经失调发生率高于PRL阴性组;生长激素(GH)阳性组血清GH增高及巨人症或肢端肥大发生率高于GH阴性组。结论垂体微腺瘤患者的临床表现、内分泌结果与病理免疫组化类型相关,可用来提高垂体微腺瘤的诊断率与治疗率。%Objective To explore the relationship between the clinical symptoms and endocrine of micro pituitary adenomas and pathological immunohistochemical type. Method We had Choosed 84 patients with micro pituitary adenomas from January 2010 to December 2012 in our hospital, then checked the endocrine, imaging and pathological of them, and analysis the relationship between the test results. Result There were 76 cases (90.47%) had endocrine symptoms in all patients, the immunohistochemical positive endocrine symptoms rate was 92.59%(75/81) , this rate was higher than the immunohistochemical negative group which rate was 33.33%(1/3), the difference was statistically signiifcant (χ2=5.92, P<0.05), this indicated that the endocrine symptoms consistent with immunohistochemical results. The increased serum PRL and amenorrhea, spilled milk or incidence of menstrual disorder rate of serum prolactin (PRL) positive group were higher than that of PRL negative groups; increased serum GH and gigantism or acromegaly fertilizer rates of growth hormone (GH) positive group were higher than GH

  18. The European Clinical, Molecular, and Pathological (ECMP Criteria and the 2007/2008 Revisions of the World Health Organization for the Diagnosis, Classification, and Staging of Prefibrotic Myeloproliferative Neoplasms Carrying the JAK2V617F Mutation

    Directory of Open Access Journals (Sweden)

    Jan Jacques Michiels

    2014-09-01

    Full Text Available OBJECTIVE: The prefibrotic stages of JAK2V617F essential thrombocythemia (ET and JAK2V617F polycythemia vera (PV can easily be diagnosed clinically without use of bone marrow biopsy histology. We assessed the 2008 WHO and European Clinical, Molecular, and Pathological (ECMP criteria for the diagnosis of myeloproliferative neoplasms (MPNs. METHODS: Studied patients included 6 JAK2V617F-mutated ET and 4 PV patients during long-term follow-up in view of critical analysis of the literature. The bone marrow biopsy histology diagnosis without use of clinical data was PV in 7 (of which 3 were cases of ET with features of early prodromal PV and classical PV in 4. RESULTS: The ECMP criteria distinguish 3 sequential phenotypes (1, 2, or 3 of JAK2V617F-mutated ET: normocellular ET-1; ET-2, with clinical and bone marrow features of PV (prodromal PV, and ET-3, with hypercellular dysmorphic megakaryocytic and granulocytic myeloproliferation (ET.MGM. The 3 patients with ET-2 or prodromal PV developed slow-onset PV after a follow-up of about 10 years. Bone marrow biopsy histology differentiates MPNs of various molecular etiologies from all variants of primary or secondary erythrocytoses and thrombocytoses with sensitivity and specificity of near 100%. CONCLUSION: Normocellular ET (WHO-ET, prodromal PV, and classical PV show overlapping bone marrow biopsy histology features with similar pleomorphic clustered megakaryocytes in the prefibrotic stages of JAK2V617F mutated MPN. Erythrocytes are below 6x1012/L in normocellular ET and prodromal PV, and are consistently above 6x1012/L in classical PV and at the time of transition from prodromal PV into classical PV. Red cell count at a cut-off level of 6x1012/L separates ET from PV and obviates the need for red cell mass measurement when bone marrow histology and JAK2V617F mutation screening are included in the diagnostic work-up of MPNs.

  19. Comparative X-ray investigation of lateral and anterior-posterior ankle-joint images - comparison with pathological and anatomical findings concerning lateral ankle-joint lesions and their clinical importance, studied in a special type of holding device

    International Nuclear Information System (INIS)

    The study reports on a possibility to interpret the relation of the different bone structures of the upper ankle-joint to one another in the X-ray picture without using contrast media. Modern funtional diagnostic methods increasingly make use of X-ray pictures taken in fixed position. It seems useful to standardize such X-ray images of the ankle-joint in order to make them reproducible. The author developed a device that would suit these purposes. A diagnosis required the reproduction of the accidental mechanism. The clinical symptoms do not permit to clearly state the extent of the lesion of the ligaments. The results of the post-operative follow-up examinations confirm the urgent necessity of the standardized diagnostic method presented and the success of the therapy applied. The presented X-ray method permits safe diagnosis of ruptures of the ligaments. Location of a certain rupture is not possible with the fixed-position X-ray screening. For a clear assessment of lesions of the ligaments at the lateral ankle-joint, X-ray pictures must be taken both in the anterior-posterior path of rays and in the lateral one. A normal result in the lateral path of rays does not exclude a pathologic result in the anterior-posterior path of rays, and vice versa. (orig./MG)

  20. Clinical, endoscopic and pathologic analysis of 36 cases of early gastric cancer%36例早期胃癌临床、内镜和病理特点分析

    Institute of Scientific and Technical Information of China (English)

    陈国栋; 刘玉兰

    2012-01-01

    [ Objective ] To analyze the feature of endoscopic and clinical characteristic of early gastric cancer and promote the diagnosis rate. [Methods] The clinical and endoscopic features of 36 patients with early gastric cancer confirmed by operation and pathologic analysis were retrospectively analyzed in our hospital during the last 3 years. [ Results ] 72% of the tumors were located in the antrum and angulus. 77.8% of the patients were older than 60 years, among which most patients were 70~79 years old. HP infection was 63.8%. Lymphatic metastasis all occurred in poorly differentiated adenocarcinoma and signet-ring cell carcinoma. [Conclusions] Endoscopic examination is very important to diagnose and cure early gastric cancer; HP infection rate seems decrease at present, which may explain the later stage of onset of early gastric cancer.%目的 探讨早期胃癌的内镜和临床特点,提高早期胃癌的检出率.方法 回顾性分析近3年来该院36例经过手术切除病理证实的早期胃癌患者的临床表现、内镜特点.结果 胃窦和胃角病变占72%;60岁以上组占到了77.8%,以70 ~ 79岁年龄组最多;早期胃癌HP感染率为63.8%;淋巴结转移发生在低分化腺癌和印戒细胞癌.结论 内镜对发现并治疗早期胃癌具有重要的作用;人群HP感染率似乎较以前降低,可以说明患者早期胃癌年龄推迟的原因.

  1. MR-pathologic correlation of lung specimens

    International Nuclear Information System (INIS)

    The aim of this study was to assess the feasibility of a new MR-pathologic correlation method utilizing a high-resolution MR technique with a 3-inch surface coil and elimination of susceptibility by replacing air in the pulmonary alveoli of lung specimens with water. Inflated cadaver lung specimens of various lung disorders were imaged using a conventional spin echo (SE) sequence in a clinical 1.5T MR scanner. The MR images were correlated with pathologic specimens. In six out of seven specimens, MR revealed detailed images corresponding to pathological changes. MR may provide a non-invasive and non-destructive method for examining lung specimens and for image-pathologic correlation

  2. Latin American forensic pathology: scope and needs

    Directory of Open Access Journals (Sweden)

    Gabriel M. Fonseca

    2012-10-01

    Full Text Available Pathology pertains to the study of a disease; from ancient times it has sought to explain the cause of death through postmortem examination. The advancement of science and technology has led to a greater definition of roles and has favored its development through different subspecialties among which we stands out forensic pathology. This discipline has its own characteristics, scope, case series, procedures and terminology. Likewise, although forensic pathology does not differ substantially from clinical pathology, significant differences can be found between the Anglo American approach and the Latin American approach. Beyond semantics of these alleged differences, the article reviews the concepts involved and discusses the scope and requirements needed to qualify experts, in the understanding that globalizing criteria should establish new paradigms and define the specific roles of the specialty.

  3. Ocular malignant lymphoma. A clinical pathological study

    Directory of Open Access Journals (Sweden)

    Panda A

    1987-01-01

    Full Text Available Eleven histologically proved cases of ocular malignant lymphoma diagnosed and managed during the year 1974-81 are reported. The follow-up period ranges from 2-7 years. The difficulties in diagnosis, treatment and prognosis are discussed.

  4. Clinic Pathological Features of Angiomyofibroblastoma in Vulva

    Institute of Scientific and Technical Information of China (English)

    CHEN Wei-xiang; TONG Shu-lan; FEI Shao-hua; CAO Zhi-xing; CAO Xiao-zhe

    2008-01-01

    Objective:To analyze the clinicopathological features and differential diagnosis of angiomyofibroblastoma(AMFB) of the vulva. Methods:Two cases of AMFB were examined by light microscopy and immunohistochemical study and to discuss the clinicopatholoical features and differential diagnosis of AMFB with the reference to the literature. Results:Tumors were all circumscribed,and<5 cm in diameter.Microscopically,the tumors were composed of spindle or polygonal cells that were cellularly or hypocellularly arranged with perivascular accentuation in a mucoid or fibrocollagenous background.The tumors contained numerous small-to medium-sized blood vessels,which were characteristically thin walled.Immunohistochemically,two cases of tumor cells were positive for vimentin,SMA,CD34(+)and FⅧ(+). Desmin and MSA were positive in one case:Cytokeratin,S-100,CD31 were negative in both. Conclusion:AMFB is a rare,benign soft tissue tumor that occurs in the genital tract of adult women.The origin remains unclear,but it is suggested that an origin from a perivascular pluripotent stem cell that is capable of myofibroblastoma differentiation.Angiomyofibroblastoma should be differentiated from other neoplasms of the vulva such as aggressive angiomyxoma, superficial angiomyxoma and cellular angiofibroma.

  5. Aspectos clínico-patológicos da intoxicação experimental por selenito de sódio em eqüinos Clinical and pathological aspects of experimental poisoning by sodium selenite in horses

    Directory of Open Access Journals (Sweden)

    Pedro Brandini Néspoli

    2001-09-01

    Full Text Available Dadas as controvérsias sobre a intoxicação por selênio, foram realizados nove experimentos com a administração de selenito de sódio, por via intramuscular, em eqüinos, com o intuito de estudar e melhor fundamentar os aspectos clínico-patológicos e toxicológicos sobre esse tema. Conseguiram-se produzir quadros com evoluções superaguda, aguda, subaguda e crônica; alguns sinais clínicos de origem nervosa observados nos quadros agudos foram similares aos descritos para "blind staggers"; a despeito disto, o carácter conflitante e duvidoso das descrições sobre essa pretensa entidade historicamente descrita, não permite uma comparação mais exata. O quadro crônico, por outro lado, configurou claramente a primeira reprodução de "alkali disease", por via parenteral, em eqüinos. Estabeleceu-se 1,49 mg/kg de selenito de sódio como a dose única letal para essa espécie. Descrevem-se diversos achados clínico-patológicos relativos aos sistemas cardiovascular e nervoso, antes não mencionados na literatura relativa aos eqüinos intoxicados por selênio. Entre eles, destacam-se, clinicamente, sopro e arritmia cardíacos, desdobramento de bulhas e convulsão. À necropsia, um animal apresentou nítido achatamento das circunvoluções cerebrais e, em relação à histopatologia, lise e necrose de neurônios do córtex, edema de astrócitos, bem como ativação endotelial e gliose. Em relação à patogênese, postula-se que as alterações degenerativo-necróticas observadas no sistema nervoso central, devam-se ao edema, por sua vez conseqüente ao aumento da permeabilidade vascular, determinada pelo selenito de sódio.Due to the numerous contradictions on selenium poisoining, and in order to improve knowledge about the clinical, pathological and toxicological aspects, experiments were performed with intramuscular injections of sodium selenite in 9 horses. Peracute, acute, subacute and chronic poisoning was reproduced; some nervous

  6. Pathologic conditions in pregnancy

    International Nuclear Information System (INIS)

    Soma authors suggested that MR imaging could rapresent an effective diagnostic alternative in the study of pathologic conditions of mother and fetus during pregnancy. To verify the actual role of MR imaging, we examined 20 patients in the 2nd and 3rd trimester of gestation, after a preliminary US examination. Fifteen patients presented fetal or placental pathologies; in 4 patients the onset of the pathologic condition occurred during pregnancy; in 1 case of US diagnosis of fetal ascites, MR findings were nornal and the newborn was healty. As for placental pathologies, our series included a case of placental cyst, two hematomas between placenta and uterine wall, and two cases of partial placenta previa. As for fetal malformation, we evaluated a case of omphalocele, one of Prune-Belly syndrome, a case of femoral asimmetry, one of thanatophoric dwarfism, a case of thoracopagus twins with cardiovascular abnormalities, two fetal hydrocephali, and three cases of pyelo-ureteral stenosis. As for maternal pathologies during pregnancy, we observed a case of subserous uterine fibromyoma, one of of right hydronephrosis, one of protrusion of lumbar invertebral disk, and a large ovarian cyst. In our experience, MR imaging exhibited high sensitivity and a large field of view, which were both useful in the investigation of the different conditions occurring during pregnancy. In the evaluation of fetal and placental abnormalities, especially during the 3rd trimester, the diagnostic yieldof MR imaging suggested it as a complementary technique to US for the evaluation of fetal malformation and of intrauterine growth retardation

  7. Pathological Gambling and Substance Use Disorders

    OpenAIRE

    Wareham, Justin D.; Potenza, Marc N.

    2010-01-01

    Pathological gambling (PG) has been considered as a behavioral addiction having similarities with substance use disorders (SUDs). Shared features exist in diagnostic, clinical, physiological, and behavioral domains. Current conceptualizations of addiction, as well as experimental studies of PG and SUDs, are reviewed in order to provide a perspective on the areas of convergence between addictive behaviors in PG and SUDs.

  8. CLINICO - PATHOLOGICAL STUDY OF CARCINOMA OF PENIS

    OpenAIRE

    Sarada; Venkataramana; Ramanaiah; De, Anuradha; Srihari Rao; Srikanth Reddy

    2015-01-01

    Carcinoma of penis is a tumor with devastating psycho sexual repercussions on the patient . It was reported from different parts of the world with wide variation in incidence . Several factors were considered as inducing agents for cancer of penis . A clinic - pathological study is undertaken to find the incidence , the probable causative factors and the possible treatment methods that can be adapted . Preputi...

  9. Diagnosis through images in mamma pathology

    International Nuclear Information System (INIS)

    Doctor Arguedas mentions the usefulness of mammography and ultrasonic. According to the patient's age and in relation to the possible pathology. He also includes the procedure to be followed, to obtain an integral diagnostic, wich will be clinic, radiological and ecographic. (S. Grainger)

  10. Clinical and pathological features of Danon disease: a study of seven patients%7例Danon病患者临床和肌肉病理特点分析

    Institute of Scientific and Technical Information of China (English)

    李秀丽; 刘智; 陈琳; 方全; 姜腾勇; 任海涛; 赵燕环; 郭玉璞

    2014-01-01

    ,dilated cardiomyopathy in 1 patient and hypertrophic cardiomyopathy combined with dilated cardiomyopathy in 1 patient.Electrocardiogram revealed pre-excitation syndrome in 5 patients.Electromyogram showed neither myogenic nor neurogenic changes in 2 patients.Autophagic vacuoles in muscle fibers were the character of muscle pathology,and some cytoplasmic vacuoles and granules were positive in dystrophin and spectrin immumohistochemical staining.Endomyocardial biopsy of 3 patients showed extensive vacuoles within some cardiac muscle fibres.Conclusions Danon disease often affects male adolescents,presenting with hypertrophic cardiomyopathy and elevated serum creatine kinase concentration,and myopathy and mental retardation are often mild and can be clinically silent sometimes,which are usually neglected and misdiagnosed as hypertrophic cardiomyopathy.What is more,heart failure is an important predictor of prognosis.Both skeletal and cardiac muscle pathology is characterized by cytoplasmic autophagic vacuoles,even when weakness is not obvious in skeletal muscles.Therefore,skeletal muscle pathology is very important to diagnosis of the disease.

  11. Clinical and pathological characteristics of primary Sj(o)gren's syndrome-associated neurological lesions%干燥综合征神经系统病变的临床及病理特征

    Institute of Scientific and Technical Information of China (English)

    金善; 曹霞; 王晓玲; 李靖; 曹秉振

    2010-01-01

    Objective To explore clinical and pathological characteristics of neurological lesions in primary Sj(o)gren's syndrome (pSS).Methods Ten patients diagnosed as pSS with nervous system involvement were analyzed retrospectively with autoimmune antibody test,cerebrespinal fluid examination and Schivmer's test,six pSS patients with peripheral nervous system lesions (PNS-pSS) were examined with electromyography and nerve conduction velocity and four pSS patients with central nervous system lesions (CNS-pSS) were examined with cranial MRI to analyze their clinical and pathological characteristics.Salivary gland biopsy was performed for all the ten patients,sural nerve biopsy for those with PNS-pSS and brain biopsy or spinal autopsy for those with CNS-pSS.Results Clinically,six patients with PNS-pSS presented symmetrical sensory-motor peripheral neuropathy or pure sensory peripheral neuropathy and four patients with CNS-pSS presented multiple sclerosis,subacute transverse myelitis,encephalitis,pituitary stroke and acute meningitis with varied lesions in the myelin sheath and axon by electromyography and motor nerve conduction velocity.Cranial MRI showed lesions in the white matter of the brain,spinal cord and abnormal signals in the pituitary.Pathologically,sural nerve biopsy showed typical vasculitis and nonvasculitis characterized as degeneration of the axon and myelin sheath,salivary acinar gland biopsy showed its atrophy and infiltration with lymphocytes,and brain biopsy showed demyelination of the brain and spinal white matter,as well as infiltration of lymphocytes surrounding the veins,typical vasculitis and bleeding and necrosis of the pituitary.Conclusions Both central and peripheral nervous systems can be involved in pSS,with complicated clinical manifestations.Electrophysiology,cerebrospinal fluid tests and histopathological examinations by biopsy are essential in diagnosis for neurological lesions in patients with pSS.Inflammatory reaction of the blood vessels

  12. Complications of Pathologic Myopia.

    Science.gov (United States)

    Cho, Bum-Joo; Shin, Joo Young; Yu, Hyeong Gon

    2016-01-01

    Pathologic myopia (PM) is one of the leading causes of visual impairment worldwide. The pathophysiology of PM is not fully understood, but the axial elongation of the eye followed by chorioretinal thinning is suggested as a key mechanism. Pathologic myopia may lead to many complications such as chorioretinal atrophy, foveoschisis, choroidal neovascularization, rhegmatogenous retinal detachment, cataract, and glaucoma. Some complications affect visual acuity significantly, showing poor visual prognosis. This article aims to review the types, pathophysiology, treatment, and visual outcome of the complications of PM. PMID:26649982

  13. Complexity and forensic pathology.

    Science.gov (United States)

    Jones, Richard Martin

    2015-12-01

    It has become increasingly apparent that nonlinearity and complexity are the norm in human physiological systems, the relevance of which is informing an enhanced understanding of basic pathological processes such as inflammation, the host response to severe trauma, and critical illness. This article will explore how an understanding of nonlinear systems and complexity might inform the study of the pathophysiology of deaths of medicolegal interest, and how 'complexity thinking' might usefully be incorporated into modern forensic medicine and forensic pathology research, education and practice. PMID:26372537

  14. Clinical features and pathology of isolated granulocytic sarcoma of the ovary%卵巢孤立性粒细胞肉瘤的临床病理观察

    Institute of Scientific and Technical Information of China (English)

    周莉; 王敏; 马广贞

    2010-01-01

    Objective To investigate the clinical and pathological features,diagnosis and differential diagnosis of isolated granulocytic sarcoma of the ovary. Methods The clinical manifestations,pathological features,immunohistochemistry,treatment and prognosis were analyzed in 1 case of isolated granulocytic sarcoma of the bilateral ovary with the review of literatures. Results Granulocytic sarcoma of the ovary was rare. Only 14 cases had been reported so far. This case presented a greenish masse arising from the right ovary measuring 10.0 cm × 8.5 cm × 6.0 cm and 4.8 cm × 3.0 cm × 2.2 cm mass in the left ovary. The neoplastic cells grew in a diffuse pattern or India file, composed of myeloid cells at various stages of maturation, being predominantly primitive myelocytes with a few immature eosinophils. Immunohistochemistry,tumor cells were strongly positive for MPO,CD117,CD43,but negative for CD79α,CD3 Conclusions In routine morpholog,granulocytic sarcoma may be misinterpreted as lymphoma,granular cell tumor,et al. Neoplastic cells at various stages of maturation,India file pattern and immature eosinophils are important diagnostic clues. Immunohistochemical stains are essential in order to obtain correct diagnosis. Despite the localized nature of tumor, intensive antileukemia chemotherapy is necessary.%目的 探讨卵巢孤立性粒细胞肉瘤的临床病理特点、诊断及鉴别诊断要点.方法 结合文献对1例双侧卵巢孤立性粒细胞肉瘤的临床表现、病理特征、免疫表型及治疗预后进行分析.结果 卵巢孤立性粒细胞肉瘤是一种罕见肿瘤,迄今查到14例报道.本例表现为右卵巢被灰绿色肿物取代,大小10.0cm×8.5 cm×6.0 cm;左卵巢大小4.8 cm×3.0 cm×2.2 cm,部分被肿瘤取代.肿瘤细胞呈弥漫性分布或列兵样排列.细胞分化程度不等,以原始未成熟细胞为主,可找到幼稚嗜酸粒细胞.免疫组化:肿瘤细胞髓过氧化物酶(MP0)(+)、CD117(+)、CD43(+)、CD79α(-)、CD3

  15. Analysis of clinical and pathological features of chronic hepatitis B with hepatic steatosis%慢性乙型肝炎合并肝脂肪变的临床与病理学特征分析

    Institute of Scientific and Technical Information of China (English)

    宓余强; 刘勇钢; 徐亮; 范建高; 张弘; 平蕾; 石瑞芳

    2009-01-01

    Objective To explore clinical and pathological features of chronic hepatitis B (CHB)with hepatic steatosis. Methods Retrospective analysis of hepatic steatosis in patients with liver biopsy-proven CHB between January 2005 and June 2008. Detailed clinical, laboratory and pathological data of CHB patients with steatosis were compared with those in sex-, age- matched CHB patients without steatosis.Patients co-infected hepatitis C virus or HIV or suffering from liver diseases of other causes were excluded.Results Histological hepatic steatosis was found in 33.4% of the 1263 CHB patients. The prevalence of steatosis was increased with time in the study period (20.3%, 28.2%, 32.6%, 65.4%, in trend analysis,P 0.05),hepatic inflammation grade and fibrosis stage between CHB patients with and without steatosis ( x~2=1.434,0.106, respectively, P > 0.05), and these parameters were not associated with different degree of hepatic steatosis (x~2=2.447, 2.911, respectively, P > 0.05). Conclusions Hepatic steatosis is common in patients with CHB, and is related to metabolic disorders. Hepatic steatosis does not affect the severity of CHB. The reverse association of hepatitis B virus titer with the degree of hepatic steatosis needs further investigation.%目的 探讨慢性乙型肝炎合并肝细胞脂肪变患者的临床病理特征.方法 回顾性调查2005年1月-2008年6月肝活组织检查确诊的慢性乙型肝炎患者肝脂肪变患病率.剔除合并HCV和人类免疫缺陷病毒等感染及其他慢性肝病,比较临床资料完整的肝脂肪变患者与其性别,年龄相配的无肝脂肪变患者的临床病理特征.计量资料采用t检验,近似正态分布时选用近似t检验,计数资料应用x~2检验. 结果 1263例慢性乙型肝炎患者肝脂肪变患病率33.4%,研究期间呈逐年增高趋势(趋势分析显示,JD0.05),肝脏病理学分级和分期差异无统计学意义(x~2值分别为1.434和0.106,P值均>0.05),不同程

  16. SurfaceSlide: A Multitouch Digital Pathology Platform

    OpenAIRE

    Wang, Yinhai; Williamson, Kate E.; Paul J. Kelly; James, Jacqueline A.; Hamilton, Peter W.

    2012-01-01

    Background: Digital pathology provides a digital environment for the management and interpretation of pathological images and associated data. It is becoming increasing popular to use modern computer based tools and applications in pathological education, tissue based research and clinical diagnosis. Uptake of this new technology is stymied by its single user orientation and its prerequisite and cumbersome combination of mouse and keyboard for navigation and annotation.Methodology: In this st...

  17. Cystic medial necrosis: pathological findings and clinical implications Necrose cística da média: manifestações patológicas com implicações clínicas

    Directory of Open Access Journals (Sweden)

    Shi-Min Yuan

    2011-03-01

    Full Text Available Cystic medial necrosis (CMN is a disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions. CMN is known to occur in certain connective tissue diseases such as Marfan syndrome, Ehlers-Danlos syndrome, and annuloaortic ectasia, which usually result from degenerative changes in the aortic wall. The relationships between CMN and congenital heart defects as well as other disorders have been evidenced. The mechanisms are still controversial, even though many molecular studies have been conducted. The aim of the present article is to provide a comprehensive overview of the CMN lesion in terms of pathologic features, clinical implications and etiologies based on molecular research results.A necrose cística da média (NCM é uma desordem das grandes artérias, em particular a aorta, caracterizada por acúmulo de substância basofílica na camada média com lesões císticas-símile. É sabido que a NCM ocorre em certas doenças do tecido conjuntivo tal como síndrome de Marfan, síndrome de Ehlers-Danlos, e ectasia ânulo-aórtica, que normalmente resulta de mudanças degenerativas na parede aórtica. A relação entre NCM e defeitos congênitos do coração, assim como outras desordens, tem sido evidenciada. Os mecanismos são ainda controversos, embora muitos estudos moleculares tenham sido conduzidos. O objetivo do presente artigo é fornecer uma visão geral da NCM em termos de características patológicas, implicações clínicas e etiologia baseada em resultados de pesquisa molecular.

  18. Clinical and pathological response rates of docetaxel-based neoadjuvant chemotherapy in locally advanced breast cancer and comparison with anthracycline-based chemotherapies: Eight-year experience from single centre

    Directory of Open Access Journals (Sweden)

    D Gupta

    2011-01-01

    Full Text Available Introduction: The administration of neoadjuvant chemotherapy (NACT prior to local therapy is advantageous for women with locally advanced breast cancer (LABC, since it can render inoperable tumors resectable and can increase rates of breast conservative surgeries. Materials and Methods: We retrospectively analyzed LABC patients who received NACT from January 2000 to December 2007. Out of 3000 case records screened, 570 (19% were LABC and 110/570 (19% treatment-naïve patients started on NACT were analyzed. Ninety-one (37 docetaxel [D], 54 anthracycline [A] patients were eligible for response and survival analysis. Pathological complete remission (pCR was defined as no evidence of malignancy in both breast and axilla. Results: Median age of the whole cohort was 45 years (range 25-68 years. Premenopausal were 42% and estrogen receptor + 49.5%. Most (90% were T4 tumors and 70% were Stage IIIB. Median numbers of preoperative cycles were six and three in the D and A group respectively. Overall clinical response rates for breast primary were 74.3% and 53.7% (CR 28.6% vs. 16.7%, P=0.58 while for axilla ORR were 75.7% vs. 54.8% (51.4% vs. 40.4% CR, P=0.77 respectively for D and A. Corresponding pCR rates were 19% vs. 13% respectively. There was no significant difference in disease-free (three-year 56.84% vs. 61.16%, P=0.80 and overall survival (three-year 70% vs. 78.5%, P=0.86 between the two groups. Conclusions: Although pCR rates were higher with docetaxel-based NACT, it did not translate into superior disease-free survival / overall survival compared to anthracycline-based chemotherapies.

  19. Summary of 2 nd Nordic symposium on digital pathology

    Directory of Open Access Journals (Sweden)

    Claes Lundström

    2015-01-01

    Full Text Available Techniques for digital pathology are envisioned to provide great benefits in clinical practice, but experiences also show that solutions must be carefully crafted. The Nordic countries are far along the path toward the use of whole-slide imaging in clinical routine. The Nordic Symposium on Digital Pathology (NDP was created to promote knowledge exchange in this area, between stakeholders in health care, industry, and academia. This article is a summary of the NDP 2014 symposium, including conclusions from a workshop on clinical adoption of digital pathology among the 144 attendees.

  20. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.

    Science.gov (United States)

    Toledo, Jon B; Gopal, Pallavi; Raible, Kevin; Irwin, David J; Brettschneider, Johannes; Sedor, Samantha; Waits, Kayla; Boluda, Susana; Grossman, Murray; Van Deerlin, Vivianna M; Lee, Edward B; Arnold, Steven E; Duda, John E; Hurtig, Howard; Lee, Virginia M-Y; Adler, Charles H; Beach, Thomas G; Trojanowski, John Q

    2016-03-01

    We investigated the distribution patterns of Lewy body-related pathology (LRP) and the effect of coincident Alzheimer disease (AD) pathology using a data-driven clustering approach that identified groups with different LRP pathology distributions without any diagnostic or researcher's input in two cohorts including: Parkinson disease patients without (PD, n = 141) and with AD (PD-AD, n = 80), dementia with Lewy bodies subjects without AD (DLB, n = 13) and demented subjects with AD and LRP pathology (Dem-AD-LB, n = 308). The Dem-AD-LB group presented two LRP patterns, olfactory-amygdala and limbic LRP with negligible brainstem pathology, that were absent in the PD groups, which are not currently included in the DLB staging system and lacked extracranial LRP as opposed to the PD group. The Dem-AD-LB individuals showed relative preservation of substantia nigra cells and dopamine active transporter in putamen. PD cases with AD pathology showed increased LRP. The cluster with occipital LRP was associated with non-AD type dementia clinical diagnosis in the Dem-AD-LB group and a faster progression to dementia in the PD groups. We found that (1) LRP pathology in Dem-AD-LB shows a distribution that differs from PD, without significant brainstem or extracranial LRP in initial phases; (2) coincident AD pathology is associated with increased LRP in PD indicating an interaction; (3) LRP and coincident AD pathology independently predict progression to dementia in PD, and (4) evaluation of LRP needs to acknowledge different LRP spreading patterns and evaluate substantia nigra integrity in the neuropathological assessment and consider the implications of neuropathological heterogeneity for clinical and biomarker characterization. PMID:26721587

  1. Pathological Gambling: Psychiatric Models

    Science.gov (United States)

    Westphal, James R.

    2008-01-01

    Three psychiatric conceptual models: addictive, obsessive-compulsive spectrum and mood spectrum disorder have been proposed for pathological gambling. The objectives of this paper are to (1) evaluate the evidence base from the most recent reviews of each model, (2) update the evidence through 2007 and (3) summarize the status of the evidence for…

  2. TC pathological Neck

    International Nuclear Information System (INIS)

    This presentation is about different imaging techniques such as ultrasound, CT, RNM, PET-CT. These techniques permit to detect head and neck tumors, breast and digestive pathologies as well as congenital diseases and glandular tumor in the thyroid, parathyroid, muscles, lymphatic, nerves and vessels

  3. Pathological Gambling Subtypes

    Science.gov (United States)

    Vachon, David D.; Bagby, R. Michael

    2009-01-01

    Although pathological gambling (PG) is regarded in the 4th edition of the "Diagnostic and Statistical Manual of Mental Disorders" (American Psychiatric Association, 1994) as a unitary diagnostic construct, it is likely composed of distinct subtypes. In the current report, the authors used cluster analyses of personality traits with a…

  4. Clinical, molecular pathological and genetic analysis of a Chinese family with dystrophinopathy%抗肌萎缩蛋白病一家系的临床、分子病理及遗传学特点

    Institute of Scientific and Technical Information of China (English)

    罗静; 熊晖; 王小竹; 钟南; 王静敏; 姜玉武; 吴希如

    2008-01-01

    目的 分析并确定1个抗肌萎缩蛋白病(dystrophinopathy)家系的临床、分子病理及遗传学特征.方法 收集先证者及其家系成员的临床资料,对先证者行肌肉活体组织检查,采用抗层黏连蛋白α2(1aminin α2,又称merosin)、抗emerin蛋白、抗肌萎缩蛋白(dystrophin)中央棒状区(Dys1)、C′末端(Dys2)、N′末端(Dys3)单克隆抗体行免疫组织化学染色;提取外周血基因组DNA,采用多重连接探针扩增(MLPA)进行抗肌萎缩蛋白Duchenne型肌营养不良(DMD)基因检测.结果 该家系中包括先证者在内共有3例患者临床诊断为肌营养不良,均无腓肠肌肥大,但病情重、进展较快,同时先证者肌肉活体组织检查行免疫组织化学染色提示dystrephin蛋白部分缺失,merosin、emerin染色呈阳性表达.MLPA检测显示先证者DMD基因第45~54外显子缺失,其母在第45~54外显子区域为杂合性缺失.结论 该家系中的先证者DMD基因为第45~54外显子缺失,突变基因来自母亲,其母为表型正常的携带者.dystrophin蛋白表达异常是造成抗肌萎缩蛋白病表型的病理基础,其临床后果不仅取决于dystrophin蛋白表达缺失的程度,还取决于DMD基因缺失区域的功能.%Objective To analyze and determine the clinical, molecular pathology and genetic features of a Chinese family with dystrophinopathy. Methods Clinical data of the proband and his family members were collected. Immunohistochemistry staining was performed on muscular biopsy tissues with antimerosin, emerin and the N, C and central rod domains of dystrophin. Genomic DNA was extracted using standard procedures from the peripheral blood leukocytes. Multiplex ligation-dependent probe amplification (MLPA) was used to test Duchenne muscular dystrophy (DMD) gene to determine the ways and sites of genetic mutation, and analyze the relationships between genotype and phenotype. Results Patients from this family were clinically diagnosed as

  5. Xanthogranulomatous pyclonephritis in childhood. Radiologic an pathologic correlation

    International Nuclear Information System (INIS)

    Xanthogranulomatous pyelonephritis in childhood. Radiologic and pathologic correlation. Four cases of xanthogranulomatous pyelonephritis in children are presented and a correlation between the main radiological and pathological findings of the two forms of presentation of the disease (focal and diffuse) is showed, with emphasis in its sonographic and computed tomographic findings. Clinical comments and a review of the literature is also presented. (author)

  6. Expectations and essentials for the community practice of pathology.

    Science.gov (United States)

    Horowitz, Richard E

    2006-08-01

    In 3 surveys during the past 10 years, community hospital pathologists were asked what they want, need, or look for when employing a pathologist and, more specifically, what skills and knowledge a newly minted pathologist should have to be successful in the community practice of pathology. The most recent survey, done in spring of 2005, cited surgical pathology diagnosis, frozen section diagnosis, gross dissection, cytology, and fine-needle aspiration as essentials in anatomic pathology. For clinical pathology, knowledge of clinical medicine and test strategies that use the laboratory for clinical problem solving was paramount. New expectations in the latest survey were knowledge of molecular pathology and experience in quality assurance procedures. New pathologists generally meet the expectations of the community hospital workplace; however, there were some deficiencies: they were not proficient in gross pathology or autopsy pathology, they were slow, and many lack the clinical knowledge and experience to be effective consultants. The principal attribute that determines success in the practice of pathology, however, is skill in communication and interpersonal relations, and this remains the major deficiency of the fledgling pathologist. PMID:16867856

  7. Intracranial pathology of the visual pathway

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Forell, W. E-mail: mueller-forell@neuroradio.klinik.uni-mainz.de

    2004-02-01

    Intracranial pathologies involving the visual pathway are manifold. Aligning to anatomy, the most frequent and/or most important extrinsic and intrinsic intracranial lesions are presented. Clinical symptoms and imaging characteristics of lesions of the sellar region are demonstrated in different imaging modalities. The extrinsic lesions mainly consist of pituitary adenomas, meningeomas, craniopharyngeomas and chordomas. In (asymptomatic and symptomatic) aneurysms, different neurological symptoms depend on the location of aneurysms of the circle of Willis. Intrinsic tumors as astrocytoma of any grade, ependymoma and primary CNS-lymphoma require the main pathology in the course of the visual pathway. Vascular and demyelinating diseases complete this overview of intracranial lesions.

  8. Retrospective analysis of clinical and pathological data of 104 cases of renal tubular-interstitial disease%肾小管-间质疾病104例临床病理资料回顾性分析

    Institute of Scientific and Technical Information of China (English)

    张宏岩; 孙瑶; 张磊

    2013-01-01

    目的 探讨肾小管-间质疾病的类型与疾病进展的关系,可为临床医生早期诊断及预防提供依据.方法 取自哈尔滨医科大学病理学教研室7 112例肾活检资料(1998年1月~2012年4月)中,诊断为肾小管-间质疾病104例,占1.46%(104/7 112).分析其临床资料,实验室检查和病理检查的相关性.结果 ①肾小管-间质性疾病的病理变化特点是:肾小球的球囊壁增厚、分层、纤维化,肾小球毛细血管壁增厚、缺血,严重的呈硬化改变;不同程度的肾小管萎缩,间质增生,炎细胞浸润和小动脉壁的增厚.②104例肾小管-间质性疾病中,有无蛋白尿之间有明显的差异(P<0.05);③有无炎细胞浸润和已浸润的多少之间有明显的差异(P<0.05);④而有关肾小球病变、肾小管萎缩、间质增生及临床实验室的其它几项指标间无明显的差异(P>0.05).结论 肾小管-间质性疾病的发生发展与有无炎细胞浸润及浸润的程度密切相关.临床表现为明显蛋白尿的患者,如果排除原发性或继发性肾小球肾炎时,早期诊断和预防可减轻肾小管萎缩、间质增生、纤维化及小动脉增厚、变性的发展.%Objective To investigate the relationship between the type and progression of the renal tubular-interstitial disease,and its value in the early diagnosis and prevention.Methods There were 104 cases of renal tubular-interstitial disease which accounts for 1.46% in all the 7 112 cases of renal biopsy in the Pathology Department of Harbin Medical University since January 1998 to April 2012.The clinical data,laboratory tests and pathological examination were analyzed.Results ①Pathological changes of tubular-interstital disease:glomerular capsule thickening,delamination,fibrosis,the glomerual capillary wall thickening,ischemia,and even sclerosis ; Varying degress of tubular atrophy,interstitial hyperplasia,inflammatory cell infiltration and thickening of small artery

  9. Practical pathology of aging mice

    Directory of Open Access Journals (Sweden)

    Piper M. M. Treuting

    2011-06-01

    Full Text Available Old mice will have a subset of lesions as part of the progressive decline in organ function that defines aging. External and palpable lesions will be noted by the research, husbandry, or veterinary staff during testing, cage changing, or physical exams. While these readily observable lesions may cause alarm, not all cause undue distress or are life-threatening. In aging research, mice are maintained until near end of life that, depending on strain and genetic manipulation, can be upwards of 33 months. Aging research has unique welfare issues related to age-related decline, debilitation, fragility, and associated pain of chronic diseases. An effective aging research program includes the collaboration and education of the research, husbandry, and veterinary staff, and of the members of the institution animal care and use committee. This collaborative effort is critical to humanely maintaining older mice and preventing excessive censorship due to non-lethal diseases. Part of the educational process is becoming familiar with how old mice appear clinically, at necropsy and histopathologically. This baseline knowledge is important in making the determination of humane end points, defining health span, contributing causes of death and effects of interventions. The goal of this paper is to introduce investigators to age-associated diseases and lesion patterns in mice from clinical presentation to pathologic assessment. To do so, we present and illustrate the common clinical appearances, necropsy and histopathological lesions seen in subsets of the aging colonies maintained at the University of Washington.

  10. Pathology informatics fellowship training: Focus on molecular pathology

    Directory of Open Access Journals (Sweden)

    Diana Mandelker

    2014-01-01

    Full Text Available Background: Pathology informatics is both emerging as a distinct subspecialty and simultaneously becoming deeply integrated within the breadth of pathology practice. As specialists, pathology informaticians need a broad skill set, including aptitude with information fundamentals, information systems, workflow and process, and governance and management. Currently, many of those seeking training in pathology informatics additionally choose training in a second subspecialty. Combining pathology informatics training with molecular pathology is a natural extension, as molecular pathology is a subspecialty with high potential for application of modern biomedical informatics techniques. Methods and Results: Pathology informatics and molecular pathology fellows and faculty evaluated the current fellowship program′s core curriculum topics and subtopics for relevance to molecular pathology. By focusing on the overlap between the two disciplines, a structured curriculum consisting of didactics, operational rotations, and research projects was developed for those fellows interested in both pathology informatics and molecular pathology. Conclusions: The scope of molecular diagnostics is expanding dramatically as technology advances and our understanding of disease extends to the genetic level. Here, we highlight many of the informatics challenges facing molecular pathology today, and outline specific informatics principles necessary for the training of future molecular pathologists.

  11. Investigation of spinal pathology in notalgia paresthetica.

    Science.gov (United States)

    Savk, Oner; Savk, Ekin

    2005-06-01

    A possible association of spinal pathology with notalgia paresthetica (NP) was investigated through clinical and radiographic evaluation. Forty-three NP patients underwent dermatologic and orthopedic examination accompanied by radiography of the spine. Sixty-one lesions in 43 patients were evaluated. In 34 patients, various vertebral pathologies were observed radiographically by a blinded investigator, and in 28 of these cases these changes were most prominent in the vertebrae which corresponded to a lesional dermatome. Thirty-seven lesions were accompanied by spinal changes decided to be relevant (60.7%). The striking correlation of NP localization with spinal pathology suggests that spinal nerve impingement may contribute to the pathogenesis of this entity. PMID:15928634

  12. Feline oral pathology

    OpenAIRE

    Costa, S.; Pais, B.; Almeida, D.; Simões, J.; Mega, A. C.; Vala, Helena

    2013-01-01

    The main pathologies of the oral cavity are of utmost importance, not only by the number of exposed individuals, but also by the consequences which stems. With the development of this work, we intend to conduct a brief approach to the same, since, specifically affecting domestic felines. Feline Lymphoplasmatic Gingivostomatitis (GELF), the Feline Odontoclastic Reabsorption Lesions (LROF) Complex and gingivitis-stomatitis-pharyngitis, have been studied, some of which are considered an enigma i...

  13. Microchimerism in Endocrine Pathology

    OpenAIRE

    Rust, Daniel W.; Bianchi, Diana W.

    2009-01-01

    Chimerism in an individual refers to the coexistence of cells arising from two distinct organisms. It can arise iatrogenically via transplant or blood transfusion, and physiologically via twin to twin transfer, or from trafficking between mother and fetus during pregnancy. Many of the diseases associated with microchimerism affect the endocrine system (e.g., autoimmune thyroid disease and diabetes mellitus type 1). Microchimerism is relevant to endocrine pathology because (a) it is associated...

  14. Analysis of Clinical and Pathological Features of 565 Cases of Bilateral Primary Breast Cancer%565例双侧原发性乳腺癌临床病理特征分析

    Institute of Scientific and Technical Information of China (English)

    张晟; 张霄蓓; 郝晓甍; 张瑾

    2012-01-01

    目的 探讨原发性双侧乳腺癌(bilateral primary breast cancer,BPBC)患者的临床病理特征.方法 收集1971年1月-2011年11月间我院诊治的565例双乳癌患者临床资料.对比分析同时性双乳癌(bilateral synchronous breast cancer)和异时性双乳癌(bilateral asynchronous breast cancer)在发病年龄、发病间隔、月经情况、家族史、肿瘤体积、临床分期、淋巴结数目、激素受体等临床病理特征的差异.结果 异时性双乳癌首发癌年龄要早于同时性双乳癌(P<0.05).同时性/异时性双乳癌在家族史、肿瘤体积、临床分期、腋淋巴结数目方面的差异均无统计学意义(P>0.05).同时性双乳癌两侧病灶内分泌受体表达一致率高于异时性双乳癌(P<0.01).无论同时性或异时性双乳癌其第二癌的肿瘤体积、临床分期和腋淋巴结情况都优于第一癌.同时性双乳癌与异时性双乳癌5年无病生存率与10年总生存率之间的差异有统计学意义(P<0.01).结论 双侧原发性乳腺癌第二癌与第一癌可视为两个完全不同的癌灶.单侧发生乳癌之后对侧乳癌发生的累积危险度逐年增加,应建立完善的随访制度.异时性双乳癌的5年无病生存率与10年总生存率均高于同时性双乳癌.%Objective To investigate the clinical and pathological features of primary bilateral breast cancer (BPBC). Methods Medical records of BPBC patients were reviewed from the Tianjin Medical University Cancer Institute and Hospital during 1. 1971-11. 2011 Data of the synchronous and asynchronous breast cancer were analyzed,including the age of tumor onset, the time interval between two cancer, menstruation, family history,the size of tumor,clinical stage,pathologic characteristics. Results First cancer onset age of the asynchronous breast cancer was earlier than that of synchronous breast cancer(P0. 05). The concordance rate of endocrine receptors in synchronous was higher than that in

  15. Clinical, endoscopic and pathologic characteristics of food allergy inducing upper gastrointestinal tract hemorrhage in 35 infants%婴儿食物过敏致上消化道出血35例分析

    Institute of Scientific and Technical Information of China (English)

    万盛华; 李香莲; 张双红; 杨文萍; 罗丽娟; 朱春晖

    2012-01-01

    目的 研究婴儿食物过敏致上消化道出血的临床表现、内镜下特点及组织病理学改变,以提高婴儿食物过敏致上消化道出血的诊断水平.方法 以江西省儿童医院2006年6月至2010年7月住院的35例食物过敏致上消化道出血患儿为研究对象,回顾分析婴儿食物过敏致上消化道出血的临床表现、内镜下特点及组织病理学改变.结果 所有患儿均有呕血和轻度-中度贫血,其中嗜酸性粒细胞升高19例,轻度低蛋白血症6例,血清IgE升高20例,血清幽门螺杆菌抗体检测阳性2例;所有患儿血小板计数均正常,肝功能及凝血象检查均正常;3例患儿行血清学食物过敏原特异性IgG抗体测定,其中2例牛奶喂养患儿对牛奶高度敏感,1例母乳喂养患儿对蛋清和(或)蛋黄高度敏感.35例患儿均呈现镜下糜烂性胃炎,且为多发性病灶,其中21例患儿病变以胃底、胃体黏膜多发糜烂为主,14例为胃体、胃窦黏膜多发性糜烂,3例伴胃窦、幽门管水肿,1例食管炎.所有患儿组织病理提示胃黏膜有嗜酸性粒细胞浸润,且均经患儿和母亲食物回避治疗有效.结论 婴儿食物过敏致上消化道出血的临床症状无特异性,以牛奶喂养多见,消化道出血是常见的表现之一,内镜下表现以胃黏膜糜烂为主,饮食回避是主要的诊断及治疗方法,且疗效肯定;胃黏膜病理学检查及结合嗜酸性粒细胞计数有助于诊断.%Objective To analyze the clinical manifestations, endoscopic features and histopathologic changes of food allergy inducing upper gastrointestinal tract hemorrhage in infants in order to improve the level of dignosis. Methods From Jun.2006 to Jul.2010 in Jiangxi Children' s Hospital, clinical manifestations, endoscopic features and pathologic changes in 35 infants who sufferred from allergic gastritis were collected and retrospectively analyzed. Results All patients had haematemesis and mild or moderate

  16. Clinical analysis of symmetrical pathological changes involving bilateral basal ganglia in 28 children.%儿童基底节对称性病变28例临床分析

    Institute of Scientific and Technical Information of China (English)

    徐三清; 刘艳; 方峰; 周华; 罗小平

    2009-01-01

    Objective To explore and analyze the pathogenesis,clinical characteristics and prognosis of symmetrical pathological changes involving bilateral basal ganglia in children. Methods Analyzing retrospectively clinical data of 28 inpatients with the performance of brain damage and symmetrical low-density lesions on plain CT scans and/or low-signal on MRI T1 weighted imaging, high-signal on MRI T2 weighted imaging involving bilateral basal ganglia. Results Six patients first had fever,cough and (or) vomiting,diarrhea and subsequently progressed rapidly to convulsions, coma and also had marked acidosis, increased blood lactate and pyruvate levels,in which three cases were diagnosed as methylmalonic acidaemia,two were diagnosed as α-keto-glutaric aciduria,one was diagnosed as lactic academia;One 7-month-old infant with delayed motor development,feeding difficulties and repeated seizure was diagnosed as lactic academia;One simple breast-feeding patient with cerebral vitamine Bl deficiency had hoarse cry,muscular weakness,convulsion and good effect to vitamine Bl intramuscular injection;Eighteen cases with hepatolenticular degeneration had muscular hypertonia,tremor, salivation, ataxia, speech unclear and memory decline, in which 13 cases were accompanied by hepatomegaly, 10 cases were accompanied by splenomegaly,two cases were accompanied by liver cirrhosis and two cases were accompanied by hypersplenism; One case with moldy sugarcane poisoning and one case with carbon monoxide-induced toxic encephopathy had cognitive and motor dysfunction which recovered slowly. Conclusion Many causes can lead to symmetrical pathological changes involving bilateral basal ganglia with diverse symptoms in children. The diseases should be diagnosed early by illness history, clinical features, imaging study and laboratory tests including the screening for metabolic disorders, which can help treat them effectively and improve the prognosis.%目的 探讨和分析儿童基底节区对称性

  17. Neurocisticercose: estudo clínico e patológico de 27 casos de necrópsia Neurocysticercosis: a clinical and pathological study of 27 necropsied cases

    Directory of Open Access Journals (Sweden)

    MÁRIO RODRIGUES MONTEMÓR NETTO

    2000-09-01

    Full Text Available Neurocisticercose é a mais frequente e disseminada neuroparasitose humana. O desenvolvimento de lesões no cérebro e leptomeninges, com consequente aparecimento de sintomas, está relacionado com a resposta imune do hospedeiro, ao número e à fase de involução dos parasitas . Relatamos os achados anatomopatológicos durante a necrópsia em 27 casos de neurocisticercose, que corresponderam a 3,1% dos casos necropsiados no serviço. 77% dos pacientes eram masculinos, com idade variando entre 18 e 85 anos. Em 26% dos casos havia história de alcoolismo. A análise clinico-patológica mostrou que 50% dos casos eram da forma assintomática, 11% da forma epiléptica, 11% da forma intraventricular e 11% da forma combinada. 33% dos pacientes apresentaram crise epiléptica como fator agravante do quadro clínico. O cisticerco era único em 60% dos casos, a forma cellulosae estava presente em 82% e a racemosa em 7% dos casos, sendo os 11% restantes portadores da forma combinada. Em 30% dos pacientes a causa mortis estava relacionada com a presença do cisticerco no sistema nervoso central. Nossos achados confirmam a alta morbidade desta parasitose.Neurocysticercosis is the most frequent and widespread neuroparasitosis of the human being. The development of brain and leptomeningeal lesions, with subsequent symptoms, are mainly related with the immune status of the host, and to the number and evolutional phase of the parasites. We present the pathological findings in 27 necropsies of patients with neurocysticercosis, which accounted for 3.1% of the necrops