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Sample records for clinical investigator inspection

  1. Good clinical practice regulatory inspections: Lessons for Indian investigator sites

    Directory of Open Access Journals (Sweden)

    R Marwah

    2010-01-01

    Full Text Available Regulatory inspections are important to evaluate the integrity of the data submitted to health authorities (HAs, protect patient safety, and assess adequacy of site/sponsor quality systems to achieve the same. Inspections generally occur after submission of data for marketing approval of an investigational drug. In recent years, there has been a significant increase in number of inspections by different HAs, including in India. The assessors/inspectors generally do a thorough review of site data before inspections. All aspects of ICH-GCP, site infrastructure, and quality control systems are assessed during the inspection. Findings are discussed during the close out meeting and a detailed inspection report issued afterward, which has to be responded to within 15-30 days with effective Corrective and Preventive Action Plan (CAPA. Protocol noncompliance, inadequate/inaccurate records, inadequate drug accountability, informed consent issues, and adverse event reporting were some of the most common findings observed during recent Food and Drug Administration (FDA inspections. Drug development is being increasingly globalized and an increased number of patients enrolled in studies submitted as part of applications come from all over the world including India. Because of the steep increase in research activity in the country, inexperienced sites, and more stakeholders, increased efforts will be required to ensure continuous quality and compliance. HAs have also made clear that enforcement will be increased and be swift, aggressive, and effective.

  2. Clinical Investigator Inspector List (CLIIL)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Clinical Investigator Inspection List (CLIIL) contains names, addresses, and other pertinent information gathered from inspections of clinical investigators who...

  3. Radiological protection of dental clinics: example of inspection methodology

    International Nuclear Information System (INIS)

    The compliance with the radiation protection requirements was investigated at dental clinics with X-ray machines in Juiz de Fora, Minas Gerais State, Brazil. A questionnaire was elaborated based on national proposal from the regulatory body and applied only to dental clinics formally registered to the Regional Council. Data were obtained from the technical responsible staff, visual inspections on equipment and facilities. Results suggest that there is a gap between the staff perception and the reality as far as the compliance with the radiation protection requirements. As the application of a questionnaire is not enough to indicated the clinic radiological situation, an analysis methodology is proposed. (author)

  4. Getting ready for inspection of investigational site at short notice

    Directory of Open Access Journals (Sweden)

    Rajendra Talele

    2010-01-01

    Full Text Available India is becoming an attractive destination for drug development and clinical research. This is evidenced by the three fold increment in clinical trial applications in last four years to the office of Drugs Controller General of India (DCGI. This upward trend is collaborative efforts of all stake holders and the quality of Indian data. Therefore to sustain this trend, it is important that stake holders such as Regulators, Sponsor, CRO, Monitor, Investigators and trial subjects required maintaining high standards of data and conduct of clinical trials. Indian regulations and the role of DCGI in quality check for Indian clinical trials is always a topic of discussion in various forums. A recent move by DCGI for conducting random inspections of investigational sites and companies at short notice, checking their compliance in accordance with the guidelines, and taking action against non-complier is welcomed. This will certainly increase over quality of the clinical trials. Quality of clinical trial conduct is measured on essential documents for their appropriateness and its correctness. It is observed that the stakeholders engaged in multitasking often overlook the requirements or appropriateness of the document due to their focused approach on a specific activity which is on priority. This can lead to serious quality problem and issues. Understanding of the process and documents reviewed by auditor is important to maintain such high quality. The proper planning and time management working on essential documents can minimize the quality issues, and we can be always ready for any type of inspection, announced or unannounced, or "short notice".

  5. Future requirements. Clinical investigations

    DEFF Research Database (Denmark)

    Qvist, V.

    2002-01-01

    Biocompatability, Cariology, Clinical trials, Dental materials, Helath services research, Human, Pedodontics......Biocompatability, Cariology, Clinical trials, Dental materials, Helath services research, Human, Pedodontics...

  6. Movement: A Clinical Investigation

    Directory of Open Access Journals (Sweden)

    Kazem Dalaie

    2015-10-01

    Full Text Available Objectives: One major drawback of orthodontic treatment is its long duration due to slow tooth movement and the pain at the onset of treatment following application of forces. There is controversy regarding the efficacy of laser for decreasing the treatment time and pain of orthodontic treatment. The purpose of this study was to investigate the effect of low level diode laser on the rate of orthodontic tooth movement and the associated pain.Materials and Methods: In this double blind randomized controlled clinical trial, 12 or- thodontic patients referring to Shahid Beheshti School of Dentistry for first premolar ex- traction were randomly selected and allocated to gallium aluminum-arsenide laser (Ga,Al,As diode laser, 880 nm, 100 mW, 5 j/cm2, 8 points, 80 seconds, continuous mode or control group. The patients initially underwent leveling and alignment using the sectional system. Force (150 gr was applied to each canine tooth via sectional closing loops. The loops were activated every month. The rate of tooth movement and pain were monitored over the treatment period and recorded on days 1, 3, 7, 30, 33, 37, 60, 63 and 67. Two-way ANOVA was used for comparison of groups.Results: There was no significant difference in terms of tooth movement and pain scores between the irradiated and non-irradiated sides at any time point (P>0.05.Conclusion: Although laser enhanced orthodontic tooth movement in the upper jaw, we failed to provide solid evidence to support the efficacy of laser for expediting tooth move- ment or reducing the associated pain.

  7. 75 FR 57472 - Clinical Investigator Training Course

    Science.gov (United States)

    2010-09-21

    ... investigational medicine; Promote communication between clinical investigators and FDA; Enhance investigators... days in advance. SUPPLEMENTARY INFORMATION: Clinical trial investigators play a critical role in the... HUMAN SERVICES Food and Drug Administration Clinical Investigator Training Course AGENCY: Food and...

  8. 21 CFR 312.68 - Inspection of investigator's records and reports.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Inspection of investigator's records and reports... and Investigators § 312.68 Inspection of investigator's records and reports. An investigator shall... officer or employee to have access to, and copy and verify any records or reports made by the...

  9. Investigation of the possibility of ultrasonic inspection of welded joints of tube plates

    International Nuclear Information System (INIS)

    A possibility of ultrasonic inspection of welded joints of the system: tube-tube plate has been studied. Methods, diagrams and devices of ultrasonic control are described. To determine the reliability of the ultrasonic inspection results, the X-ray diffraction and, sometimes, metallographic analyses were used for inspection of all the welded joints. The investigation results have shown, that the ultrasonic control method has a good sensitivity. Minimum size of the revealed defect of a pore type, when inspecting, is 0.6 mm at 5MHz frequency and 0.3 mm at 15 MHz frequency

  10. Norovirus outbreak at a wildland fire base camp ignites investigation of restaurant inspection policies.

    Science.gov (United States)

    Britton, Carla L; Guzzle, Patrick L; Hahn, Christine G; Carter, Kris K

    2014-01-01

    Norovirus outbreaks occur worldwide and have been associated with congregate settings (e.g., military and recreational camps). Investigation of a norovirus outbreak at a wildland fire base camp identified 49 (27%) illnesses among approximately 180 responders. Epidemiologic evidence implicated a restaurant as the infection source. Eight (89%) of nine wildland fire responder groups who ate at the restaurant had ill members; no groups who ate elsewhere reported ill members. An environmental health specialist restaurant inspection identified lack of managerial knowledge to protect against foodborne disease one year after the restaurant's opening; earlier inspection after opening might have led to earlier intervention. States were surveyed to determine existence of any policy or rule for food establishment inspection after opening and inspection timing. Among 18 states, five had no state rule or policy; nine had a policy in place; and four required postopening inspection by rule. Further research is needed to evaluate post-opening inspection efficacy and timing. PMID:25185322

  11. 78 FR 63988 - Clinical Investigator Training Course

    Science.gov (United States)

    2013-10-25

    ... HUMAN SERVICES Food and Drug Administration Clinical Investigator Training Course AGENCY: Food and Drug... cosponsoring a 3- day training course for clinical investigators on scientific, ethical, and regulatory aspects of clinical trials. This training course is intended to provide clinical investigators with...

  12. [Clinical investigation of striatocapsular infarction].

    Science.gov (United States)

    Tei, H; Uchiyama, S; Maruyama, S

    1993-03-01

    We investigated the clinical profile, etiological factors, neuropsychological features and radiological characteristics of 17 cases of striatocapsular infarction (SCI). SCI was defined as the following CT criteria: the area of infarction included the internal capsule and striatum, the maximum diameter of the lesion exceeded 2.0 cm without cortical involvement. There were 9 men and 8 women with mean age of 58 years. Five patients had lesions mainly involving the caudate head (anterior type) and the other 12 had lesions mainly involving the putamen (lateral type), 6 with left side lesion and 6 with right side lesion. Motor weakness was observed in all patients, and the upper extremities were preferentially involved, while in 9 patients face, upper and lower extremities were simultaneously involved. Etiological investigation revealed that 8 patients were cardioembolic stroke, 2 were artery-to-artery embolism and 2 were MCA stem occlusive disease, while the remaining 5 were undetermined. When compared with patients with lacunar infarction (LI), patients with SCI had significantly more frequent cardioembolic sources (47% vs 17%, p abulia, depression and agitation, while left lateral type patients had aphasia and right lateral type patients had hemispatial neglect or anosognosia. These symptoms gradually improved, although in most patients subtle abnormalities lasted over chronic phase. In 11 out of 13 patients who underwent SPECT using 99mTc-HMPAO, blood flow was decreased in overlying cerebral cortex besides the infarcted area.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8334792

  13. 77 FR 60440 - Clinical Investigator Training Course

    Science.gov (United States)

    2012-10-03

    ... HUMAN SERVICES Food and Drug Administration Clinical Investigator Training Course AGENCY: Food and Drug... are cosponsoring a 3- day training course for clinical investigators on scientific, ethical, and regulatory aspects of clinical trials. This training course is intended to provide clinical...

  14. 76 FR 45577 - Clinical Investigator Training Course

    Science.gov (United States)

    2011-07-29

    ... HUMAN SERVICES Food and Drug Administration Clinical Investigator Training Course AGENCY: Food and Drug... for clinical investigators on scientific, ethical, and regulatory aspects of clinical trials. This training course is intended to provide investigators with expertise in the design, conduct, and analysis...

  15. Clinical relevance of studies on the accuracy of visual inspection for detecting caries lesions: a systematic review.

    Science.gov (United States)

    Gimenez, Thais; Piovesan, Chaiana; Braga, Mariana M; Raggio, Daniela P; Deery, Chris; Ricketts, David N; Ekstrand, Kim R; Mendes, Fausto Medeiros

    2015-01-01

    Although visual inspection is the most commonly used method for caries detection, and consequently the most investigated, studies have not been concerned about the clinical relevance of this procedure. Therefore, we conducted a systematic review in order to perform a critical evaluation considering the clinical relevance and methodological quality of studies on the accuracy of visual inspection for assessing caries lesions. Two independent reviewers searched several databases through July 2013 to identify papers/articles published in English. Other sources were checked to identify unpublished literature. The eligible studies were those which (1) assessed the accuracy of the visual method for detecting caries lesions on occlusal, approximal or smooth surfaces, in primary or permanent teeth, (2) used a reference standard, and (3) reported data about sample size and accuracy of the methods. Aspects related to clinical relevance and the methodological quality of the studies were evaluated. 96 of the 5,578 articles initially identified met the inclusion criteria. In general, most studies failed in considering some clinically relevant aspects: only 1 included study validated activity status of lesions, no study considered its prognosis, 79 studies did not consider a clinically relevant outcome, and only 1 evaluated a patient-centred outcome. Concerning methodological quality, the majority of the studies presented a high risk of bias in sample selection. In conclusion, studies on the accuracy of the visual method for caries detection should consider clinically relevant outcomes besides accuracy; moreover, they should be conducted with higher methodological quality, mainly regarding sample selection. PMID:25571967

  16. Investigation of smart inspection of critical layer reticles using additional designer data to determine defect significance

    Science.gov (United States)

    Volk, William W.; Hess, Carl; Ruch, Wayne; Yu, Zongchang; Ma, Weimin; Fisher, Lisa; Vickery, Carl; Ma, Z. Mark

    2003-12-01

    With expected implementation of low k1 lithography on 193nm scanners for 65nm node wafer production, high resolution defect inspection will be needed to insure reticle quality and reticle manufacture process monitoring. Reticle cost and reticle defectivity are both increasing with each shrink to the next node. Simultaneously, system on chip (SoC) designs are increasing in which a large area of the exposure field typically contains dummy patterns and other features which are not electrically active. Knowing which defects will electrically impact device yield and performance can improve reticle manufacturing yield and cycle time -- resulting in lower reticle costs. This investigation examines the feasibility of using additional design data layers for die-to-database reticle inspection to determine in real time the relevance of a reticle defect by its location in the device (Smart InspectionTM). The impact to data preparation and inspection throughput is evaluated. The current prototype algorithm is built on the XPA and XPE die-to-database algorithms for chrome-on-glass and EPSM reticles, respectively. The algorithms implement variable sensitivity based on the additional design data regions. During defect review the defects are intelligently binned into the different predetermined design regions. Tests show the new Smart Inspection algorithm provides the capability of using higher than normal sensitivity in critical regions while reducing sensitivity in less critical regions to filter total defect counts and allow for the review of just defects that matter. Performance characterization of a variable sensitivity Smart Inspection algorithm is discussed in addition to the filtering of the total defect count during review to show the defects that matter to device performance. Using seven critical layer production reticles from a system on chip device we examine the applications of Smart Inspection by layer including active, poly, contact, metal and via layers. Data volume

  17. A European approach to clinical investigator training

    OpenAIRE

    Jean-MarieBoeynaems; CindyCanivet; AnthonyChan; Mary JaneClark; CatherineCornu; EstherDaemen; JacquesDemotes; KatelijneDe Nys; BarryHirst; FerdinandHundt; BehrouzKassai; Sandor-Kerpel-Fronius; LucyKiessig; HeinrichKlech; Jean-PierreKraehenbuhl

    2013-01-01

    A better education and training of clinical investigators and their teams is one of the factors that could foster the development of clinical research in Europe, a key objective of the Innovative Medicines Initiative (IMI). PharmaTrain (an IMI programme on training in medicines development) and ECRIN (European Clinical Research Infrastructures Network) have joined forces to address this issue. An advisory group composed of representatives of universities, pharmaceutical companies and other o...

  18. Clinical relevance of studies on the accuracy of visual inspection for detecting caries lesions

    DEFF Research Database (Denmark)

    Gimenez, Thais; Piovesan, Chaiana; Braga, Mariana M;

    2015-01-01

    the clinical relevance and methodological quality of studies on the accuracy of visual inspection for assessing caries lesions. Two independent reviewers searched several databases through July 2013 to identify papers/articles published in English. Other sources were checked to identify unpublished...... literature. The eligible studies were those which (1) assessed the accuracy of the visual method for detecting caries lesions on occlusal, approximal or smooth surfaces, in primary or permanent teeth, (2) used a reference standard, and (3) reported data about sample size and accuracy of the methods. Aspects...

  19. Supplemental site inspection for Air Force Plant 59, Johnson City, New York, Volume 1: Investigation report

    Energy Technology Data Exchange (ETDEWEB)

    Nashold, B.; Rosenblatt, D.; Hau, J. [and others

    1995-08-01

    This summary describes a Supplemental Site Inspection (SSI) conducted by Argonne National Laboratory (ANL) at Air Force Plant 59 (AFP 59) in Johnson City, New York. All required data pertaining to this project were entered by ANL into the Air Force-wide Installation Restoration Program Information System (IRPIMS) computer format and submitted to an appropriate authority. The work was sponsored by the United States Air Force as part of its Installation Restoration Program (IRP). Previous studies had revealed the presence of contaminants at the site and identified several potential contaminant sources. Argonne`s study was conducted to answer questions raised by earlier investigations.

  20. Clinical investigation of radioallergosorbent test (RAST)

    International Nuclear Information System (INIS)

    Relationship of radioallergosorbent test (RAST), intracutaneous reaction, serum IgE determination and RMCD (Rat Mast Cell Degranulation Test) in subjects with tick allergy was compared in order to investigate clinical application for nasal allergy. 1. RAST is suitable for clinical examinations as determination of IgE. Because it is simple in technique, a technical expert can treat many subjects within a short time, and the result can be decleared within 2 days. 2. RAST was high in specificity and was consistent with clinical findings. RAST positive was thought to be allergy by the antigen, but RAST negative could not deny allergy by the antigen. 3. Correlation of some degree was found to exist between RAST and intracutaneous reaction or degree of induced reaction or threshold value of antigen intracutaneous reaction. But degree of intracutaneous reaction and induced reaction and threshold value of intracutaneous reaction could not be determined from the result of RAST. 4. Determination of IgE antibody by RAST was more useful in clinical study than that of IgE or IgE antibody by RMCD. (Oyama, S.)

  1. Conduct of inspections for plant modifications, event investigations and operability decisions. Proceedings of an International Workshop

    International Nuclear Information System (INIS)

    Preliminary planning started following the approval given by the CNRA. Formal planning for the Workshop was started at the Fifth Meeting of the WGIP in April 1993, in Lyon. Planning included taking into consideration comments made and lessons learned at the first Workshop. The first organising committee meeting for the Workshop was held in London preceding the Sixth WGIP meeting in October 1993. It was decided to remain with the same format: discussion groups with facilitators. It was also decided to have a three day programme with three Discussion Group sessions. The Announcement and Call for Participation was issued in December 1993. As part of the Announcement and Call for Participation, registrants were requested to transmit questions or issues of particular interest within the selected topics, they wanted to be addressed at the Workshop. A compilation of the these is included as Appendix H. Additionally, participants were requested to provide a short paper of one or two pages, describing the practices within their own countries related to the topics, for utilisation during the discussion sessions. These papers are attached as Appendix I. A training session was held for all facilitators on the afternoon of 22 May, to introduce methods in leading small group discussions and to complete final preparations. The Workshop programme (Appendix B) consisted of an opening plenary session, 3 discussion group sessions and a closing plenary session to review conclusions and an open question period. Following completion of the Workshop, facilitators met to evaluate and formulate final reports on the various topics. The main objectives of the Workshop were the following: To meet with inspectors from other organisations, To exchange information regarding regulatory inspections practices, To discuss the major topics: plant modifications, event investigation, and operability decisions, To discuss current issues, To develop conclusions on the topics discussed. Six discussion

  2. 21 CFR 312.70 - Disqualification of a clinical investigator.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Disqualification of a clinical investigator. 312... and Investigators § 312.70 Disqualification of a clinical investigator. (a) If FDA has information indicating that an investigator (including a sponsor-investigator) has repeatedly or deliberately failed...

  3. Clinical investigation of proximate exposed group, 1

    International Nuclear Information System (INIS)

    In order to investigate effects of the A-bombing on prevalence of diabetes mellitus, follow-up studies were made on 5907 A-bomb survivors who received glucose tolerance test (GTT) during 20 years between 1963 and 1983. The A-bomb survivors were divided into the group A (1899 men and 1165 women exposed within 1.9 km from the hypocenter) and the group B (1725 men and 1118 women exposed 3.0 km or farther from it). Among non-obese survivors, 21.9% and 21.8% were being treated for diabetes mellitus or were evaluated as having diabetic type on GTT in the group A and the group B, respectively; while this was seen in 52.1% of obese survivors in the group A and 49.9% in the group B. There was no difference between the groups. In non-obese survivors, the annual development rate from the normal type to the diabetic type was 0.89% in the group A and 0.65% in the group B; the annual development rate from the borderline type to the diabetic type was 5.73% in the group A and 5.49% in the group B, showing no differences between the groups. The annual development rate from the normal or borderline type to the diabetic type was two times or higher in obese survivors than in non-obese survivors irrespective of exposure status. Regarding the number of diabetic survivors who became non-diabetic type in spite of having no treatment, and prevalence of diabetic complications, no difference was seen between the groups. These results suggest that the A-bombing has scarcely influenced the prevalence of diabetes mellitus and clinical course. (Namekawa, K.)

  4. 21 CFR 812.119 - Disqualification of a clinical investigator.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Disqualification of a clinical investigator. 812... SERVICES (CONTINUED) MEDICAL DEVICES INVESTIGATIONAL DEVICE EXEMPTIONS Responsibilities of Investigators § 812.119 Disqualification of a clinical investigator. (a) If FDA has information indicating that...

  5. Oligocone trichromacy: clinical and molecular genetic investigations

    DEFF Research Database (Denmark)

    Andersen, Mette K G; Christoffersen, Nynne L B; Sander, Birgit; Edmund, Carsten; Larsen, Michael; Grau, Tanja; Wissinger, Bernd; Kohl, Susanne; Rosenberg, Thomas

    2010-01-01

    PURPOSE: To describe the phenotype and genotype of patients with a diagnosis of oligocone trichromacy (OT). METHODS: Six unrelated patients had a detailed ophthalmic examination including color vision testing, a Goldmann visual field test, fundus photography, and full-field electroretinography (ff...... congenital nystagmus, and subjectively normal or near-normal color vision; five patients reported photophobia. Clinical examinations revealed largely normal fundi, normal Goldmann visual field results with the IV/4e target, and normal color discrimination or mild color vision deficiency. Electrophysiological...

  6. Clinical investigation of malignant parotid tumors

    International Nuclear Information System (INIS)

    We reviewed 55 cases of previously untreated malignant tumors arising in the parotid gland treated between Jan 1989 and May 2008. Histopathologically, we observed 13 tumor types, the most frequent histological type being mucoepidermoid carcinoma (12), followed by adenoid cystic carcinoma (11). According to clinical stage, 5 subjects were classified as T1, 18 as T2, 10 as T3, and 22 as T4. N+ cases numbered 7, and were staged as N2. Six had distant metastasis (5 lung and 1 axillary). Nineteen exhibited facial nerve palsy before treatment. Among major therapies, surgery was conducted in 50 subjects, radiation therapy in 3, and chemotherapy, and percutaneous ethanol injection therapy in each. Overall five-year survival determined using the Kaplan-Meier method was 73%. Among major histopathological types, five-year survival was 33% for undifferentiated carcinoma, 40% for adenocarcinoma, 62% for mucoepidermoid carcinoma, 67% for carcinoma in pleomorphic adenoma, and 100% for adenoid cystic carcinoma and acinic cell carcinoma. By T classification, five-year survival was 100% for T1, 88% for T2, 90% for T3, and 44% for T4. Five-year survival was 36% for those exhibiting facial nerve palsy and 94% for non palsy. Factors influencing poor outcome were T4 (p=0.001) and facial nerve palsy (p=0.001). (author)

  7. Measurements of body protein for clinical investigation

    International Nuclear Information System (INIS)

    Body protein (nitrogen) is determined by bilaterally irradiating the body with neutrons using Pu-Be sources and measuring the resultant 10.8 MeV gamma rays from the reaction 14N(n,8) 15N. In the authors lab the whole body can be scanned or separate segments of the body can be measured independently. A nitrogen index has been developed based on body size and is used as a predictor of normal total body nitrogen (TBN). They have found that TBN, when normalized to body size in this way, provides a reliable index of protein status which cannot be accurately determined by body weight, anthropometry, or body potassium measurements. Changes in body composition with age were studied by measuring the composition of 56 healthy female volunteers aged 20-80. Measurements were made for K(40K), Ca and N. It was shown that protein and bone mineral decrease with age but that this is not reflected in K or anthropometry measurements. Results of other studies to be presented include: body protein measurements pre and post TPN (total parenteral nutrition), nutritional status of patients on long term CAPD (continuous ambulatory peritoneal dialysis) and changes in body composition as a result of TPN in patients with small cell lung cancer receiving chemotherapy. Clinical results show that indirect measurements of body protein based on weight, potassium, or anthropometry, do not give an accurate measure of body protein. For an accurate measurement, direct measurement of body protein is necessary

  8. Aspects of Inspection Planning

    DEFF Research Database (Denmark)

    Faber, M. H.; Sørensen, John Dalsgaard

    Inspection planning for systems is considered with special emphasis to the effect of the quality of inspections on the system reliability and the probability of repair. Inspection quality is described and discussed in terms of inspection reliability and inspection coverage where the latter is set...... theoretical framework for updating of the reliability of components and systems on the basis of inspection results is outlined. Systems representative for inspection planning of different engineering systems subjected to typical deterioration processes are presented. Numerical simulation studies are performed...... on the presented systems and the effect of inspection reliability and coverage is investigated for systems of different sizes. The results of the studies illustrate the effect of inspections in practical inspection problems and can be used as an initial guideline for selecting the quality of...

  9. Clinical significance of nuclide renal dynamic imaging and urine microalbumin inspection of type II diabetic patients

    International Nuclear Information System (INIS)

    To investigate clinical value of glomerular filtration rate (GFR) and urine microalbumin in early diagnosis of diabetic nephropathy, GFR in 60 patients with type II diabetes mellitus and a control group of 20 were determined using 99TcmDTPA renal dynamic imaging and urine microalbumin. The following results were obtained.Among the 60 patients with diabetes, 5 patients had increased GFRs of, 142.0±13.6 mg/min, which was 35% higher than that of controls and differed significantly from the control (P<0.01); 20 patients had GFRs of 102.2±10.2 mg/min, which differed little from the control; and 35 patients had declined GFRs of 57.2±18.0 mg/min, which was 54.3% lowered than the control and differed significantly from the control (P<0.01). The urine microalbumin in diabetes patients was significantly higher than the control. In conclusion, the GFR is a good index of the early kidney injury in diabetic patients. The combined detection of GFR and urine microalbumin can improve the early diagnosis of diabetic nephropathy, and may help to monitor the treatment response and assess prognosis. (authors)

  10. HIV Vaccine Development: Strategies for Preclinical and Clinical Investigation

    OpenAIRE

    Shapiro, Stuart Z.

    2013-01-01

    This article discusses HIV vaccine discovery and candidate vaccine testing in the context of current realities of funding and clinical trial practice. Lacking perfect animal models for testing candidate HIV vaccines, clinical investigators have proposed a strategy of iterative exploratory clinical trials in the model of cancer chemotherapy development. Problems with the appropriateness of this model to HIV vaccine development are discussed. Also, the future feasibility of this strategy in the...

  11. US food and drug administration Indian site inspections: An experience

    Directory of Open Access Journals (Sweden)

    Pooja Mahajan

    2012-01-01

    Full Text Available Since 2005, USFDA has begun inspections of Indian clinical trial investigator sites. This paper reports experience of an FDA inspection performed at two Indian centers. The inspection started with an in-depth discussion with the investigator and his team about the conduct of the clinical trial at the site and was followed by a tour of the important locations - registration, outpatient department, specialty clinic, medical record section, and special procedure department. The inspector reviewed the critical processes - protocol compliance, ethics committee approval, informed consent process, case record form and source documents completion, investigational product accountability, serious adverse events documentation and reporting. The inspector reviewed all documents from the investigator site file and conducted audit of all subjects enrolled at both the sites. As the Indian sites are not exposed to regulatory inspections, it is vital for the sponsor to conduct preinspection audit, provide training and support to face the FDA inspection.

  12. Investigation of reliability of EC method for inspection of VVER steam generator tubes

    International Nuclear Information System (INIS)

    Complete and accurate non-destructive examinations (NDE) data provides the basis for performing mitigating actions and corrective repairs. It is important that detection and characterization of flaws are done properly at an early stage. EPRI Document PWR Steam Generator Examination Guidelines recommends an approach that is intended to provide the following: Ensure accurate assessment of steam generator tube integrity; Extend the reliable, cost effective, operating life of the steam generators, and Maximize the availability of the unit. Steam Generator Eddy Current Data Analysis Performance Demonstration represents the culmination of the intense two-year industry effort in the development of a performance demonstration program for eddy current testing (ECT) of steam generator tubing. It is referred to as the Industry Database (IDB) and provides a capability for individual organizations to implement SG ECT performance demonstration programs in accordance with the requirements specified in Appendices G and H of the ISI Guidelines. The Appendix G of EPRI Document PWR Steam Generator Examination Guidelines specifies personnel training and qualification requirements for NDE personnel who analyze NDE data for PWR steam generator tubing. Its purpose is to insure a continuing uniform knowledge base and skill level for data analysis. The European methodology document is intended to provide a general framework for development of qualifications for the inspection of specific components to ensure they are developed in a consistent way throughout Europe while still allowing qualification to be tailored in detail to meet different nation requirements. In the European methodology document one will not find a detailed description of how the inspection of a specific component should be qualified. A recommended practice is a document produced by ENIQ to support the production of detailed qualification procedures by individual countries. VVER SG tubes are inspected by EC method but a

  13. Disclosure of investigators' recruitment performance in multicenter clinical trials

    DEFF Research Database (Denmark)

    Dal-Ré, Rafael; Moher, David; Gluud, Christian;

    2011-01-01

    Rafael Dal-Ré and colleagues argue that the recruitment targets and performance of all site investigators in multi-centre clinical trials should be disclosed in trial registration sites before a trial starts, and when it ends.......Rafael Dal-Ré and colleagues argue that the recruitment targets and performance of all site investigators in multi-centre clinical trials should be disclosed in trial registration sites before a trial starts, and when it ends....

  14. Investigating the visual inspection subjectivity on the contrast-detail evaluation in digital mammography images

    Science.gov (United States)

    Sousa, Maria A. Z.; Medeiros, Regina B.; Schiabel, Homero

    2014-03-01

    A major difficulty in the interpretation of mammographic images is the low contrast and, in the case of early detection of breast cancer, the reduced size of the features of malignancy on findings such as microcalcifications. Furthermore, image assessment is subject to significant reliance of the capacity of observation of the expert that will perform it, compromising the final diagnosis accuracy. Thinking about this aspect, this study evaluated the subjectivity of visual inspection to assess the contrast-detail in mammographic images. For this, we compared the human readings of images generated with the CDMAM phantom performed by four observers, enabling to determining a threshold of contrast visibility in each diameter disks present in the phantom. These thresholds were compared graphically and by statistical measures allowing us to build a strategy for use of contrast and detail (dimensions) as parameters of quality in mammography.

  15. The clinical investigator-subject relationship: a contextual approach

    OpenAIRE

    Resnik David B

    2009-01-01

    Abstract Background The nature of the relationship between a clinical investigator and a research subject has generated considerable debate because the investigator occupies two distinct roles: clinician and scientist. As a clinician, the investigator has duties to provide the patient with optimal care and undivided loyalty. As a scientist, the investigator has duties to follow the rules, procedures and methods described in the protocol. Results and conclusion In this article, I present a con...

  16. Clinics, regulatory inspections and regulations concerning the use of soft X-rays and HDRs

    International Nuclear Information System (INIS)

    The medical use of soft X-ray and brachytherapy equipment, in Brazil, is analysed following norms, standards and recommendations from the National Nuclear Energy Commission (CNEN), the Health Ministry (MS), the Institute of Radioprotection and Dosimetry (IRD), the National Institute of Metrology, Normalisation and Industrial Quality (INMETRO), the National Laboratory of Ionising Radiation Metrology (LNMRI), the Brazilian Association of Medical Physics (ABFM), the Brazilian Association of Technical Norms (ABNT) and the International Atomic Energy Agency (IAEA). The present analysis shows that CNEN's and MS's regulations do not cover soft X-ray equipment, that normative inspections carried out by IRD do not include HDR and soft X-ray dosimetry, LNMRI - assigned by INMETRO as the reference laboratory for ionising radiation metrology - does not calibrate dosemeters for brachytherapy, ABNT does not adopt quantities and dose limits standardised by CNEN, ABFM bases its recommendations on bibliographic references where the standard quantities are not among LNMRI standards and IAEA recommends procedures for soft X-ray dosimetry that have been criticised in the literature. It is thus concluded that there is no formal control over the use of soft X-ray and HDR equipment, and that existing regulations are not sufficient for what it is expected of their utilisation in the treatment of malignant tumours. (author)

  17. Assessment of technical documentation of medical devices for clinical investigation

    NARCIS (Netherlands)

    Roszek B; Bruijn ACP de; Drongelen AW van; Geertsma RE; BMT

    2007-01-01

    The technical documentation on non-market approved medical devices intended for clinical investigation contains major shortcomings. This could imply increased risks which could affect patient safety. The investigation described here focused on the availability and quality of the technical documentat

  18. 76 FR 20575 - Disqualification of a Clinical Investigator

    Science.gov (United States)

    2011-04-13

    ... at 62 FR 46875, September 5, 1997; clarifying FDA's authority to reach sponsor-investigators under... clinical investigator's disqualification. \\5\\ 63 FR 55873 at 55874, October 19, 1998. We propose to change... example, the final rule at 62 FR 46875, September 5, 1997; clarifying FDA's authority to reach...

  19. Genetic and Clinical Investigation of Noonan Spectrum Disorders

    OpenAIRE

    Ekvall, Sara

    2012-01-01

    Noonan spectrum disorders belong to the RASopathies, a group of clinically related developmental disorders caused by dysregulation of the RAS-MAPK pathway. This thesis describes genetic and clinical investigations of six families with Noonan spectrum disorders. In the first family, the index patient presented with severe Noonan syndrome (NS) and multiple café-au-lait (CAL) spots, while four additional family members displayed multiple CAL spots only. Genetic analysis of four RAS-MAPK genes re...

  20. Zirconia abutments and restorations: from laboratory to clinical investigations.

    Science.gov (United States)

    Ferrari, M; Vichi, A; Zarone, F

    2015-03-01

    In last years the use of zirconia in dentistry has become very popular. Unfortunately, the clinical indications for a dental use of zirconia are not completely clear yet, neither are their limitations. The objective of this review was to evaluate the basic science knowledge on zirconia and to discuss some aspects of the clinical behavior of zirconia-based restorations. In particular, one of the goals was highlighting the possible correlation between in vitro and in vivo studies. The definition of concepts like success, survival and failure was still debated and the correlation between in vitro results and predictability of clinical behavior was investigated. PMID:25576437

  1. Legal issues in human clinical investigation: a primer for physicians.

    Science.gov (United States)

    Green, A M; Steinmetz, N D

    1997-01-01

    Human clinical investigation plays a central role in contemporary nuclear cardiology. It is a complex expensive endeavor triggering multiple responsibilities not otherwise encountered by physicians in clinical practice. Clinical investigators, drug and device manufacturers, hospitals and universities, governmental agencies, research subjects, patient advocacy groups, and investors all have a legitimate interest in the conduct and the outcome of clinical research. Past abuses of research subjects in many countries including those unknowingly exposed to radioactive isotopes have raised ethical concerns that are now addressed by overlapping laws, regulations, guidelines, and institutional policies that have evolved to guide the research enterprise. The policies underlying this legal and regulatory structure include protection of research subjects, protection of the integrity of research design and research data, and protection of the public and private purse. Knowledge of these laws and regulations is essential for physicians participating in clinical investigations to protect their professional and personal interests. This article reviews legal issues relevant to physicians conducting human clinical trials in the United States. PMID:9456195

  2. Investigation into the propagation and inspection of stress corrosion cracks under compressive loading

    OpenAIRE

    Dollah, Mahmood

    2007-01-01

    Eddy current testing has become a widely used nondestructive technique for material testing and evaluation. This technique depends on the interaction between the impedance of the test coil and the material as the probe scans the surface of a material under investigation. By measuring the change in impedance of the test coil, the size of an imperfection in the material can be determined. In this project, the first aim of the research was to investigate and develop the use of the...

  3. Comparative clinical and haematological investigations in lactating cows with subclinical and clinical ketosis

    Directory of Open Access Journals (Sweden)

    Vania Marutsova

    2015-10-01

    Full Text Available Ketosis of lactating cows is among the most common metabolic diseases in modern dairy farms. The economic importance of the disease is caused by the reduced milk yield and body weight loss, poor feed conversion, lower conception rates, culling and increased mortality of affected animals. In the present study, a total of 47 high-yielding dairy cows up to 45 days in milk (DIM are included. All animals were submitted to physical examination wich included checking the rectal body temperature, heart rate, respiratory and rumen contraction rates, and inspection of visible mucous coats. The body condition was scored, and blood β-hydroxybutyrate (BHBA concentrations were assayed. The cows were divided into 3 groups: first group (control (n=24 with blood β-hydroxybutyrate level 2.6 mmol/l (clinical ketosis. Whole blood samples were obtained and analyzed for Red Blood Cell (RBC, 1012/l, Hemoglobin (HGB, g/l, Hematocrit (HCT, %, Mean Corpuscular Volume (MCV, fl, Mean Corpuscular Hemoglobin (MCH, pg, Mean Corpuscular Hemoglobin Concentration (MCHC, g/l, White Blood Cell (WBC, 109/l, Lymphocytes (LYM, 109/l, Monocytes (MON, 109/l, Granulocytes (GRA, 109/l, Red Blood Distribution Width (RDW, %, Red Blood Cell Distribution Width Absolute (RDWa, fl, Platelets (PLT, 109/l and Mean Platelet Volume (MPV, fl. In this study, deviations in the clinical parameters in the control group and in those with subclinical ketosis were not identified. The cows from the third group (clinical ketosis exhibited hypotonia, anorexia and body weight loss vs. control group. Hematological analysis showed leukocytosis and lymphocytosis in cows with subclinical ketosis vs. control group. In cows with clinical ketosis WBC counts decreased (leukopenia, while hemoglobin content and hematocrit values are higher vs. control group. Blood BHBA values are higher in both groups of ketotic cows vs. the control group. The other analyzed parameters (RBC, MCH, MCHC, MCV, RDW, RDWa, MON, GRA, PLT

  4. Nondestructive, in-process inspection of inertia friction welding : an investigation into a new sensing technique.

    Energy Technology Data Exchange (ETDEWEB)

    Hartman, D. A. (Daniel A.); Cola, M. J. (Mark J.); Dave, V. R. (Vivek R.); Dozhier, N. G. (Nathan G.); Carpenter, R. W. (Robert W.)

    2002-01-01

    This paper investigates the capabilities of a new sensor for in-process monitoring of quality during friction welding. The non-contact sensor is composed of microphones that are mounted in an aluminum ring which surrounds the weld joint. The sensor collects the acoustical energy (in the form of sound pressure) that is emitted during the plastic deformation and phase transformations (if applicable) in friction welding processes. The focus in this preliminary investigation is to search for and identify features within the acoustical emission that are indicative of bond quality. Bar-to-bar inertia friction welding (one form of friction welding) of copper to 304L stainless steel is used in this proof-of-concept study. This material combination exhibits only marginal weldability and is ideally suited for validating the capabilities of this new sensing technique. A probabilistic neural network is employed in this work to analyze the acoustical emission's frequency spectrum in an attempt to classify acceptable, conditional, and unacceptable welds. Our preliminary findings indicate that quality-based process features do exist within the frequency spectrum of the acoustical signature. The results from this analysis are presented. Future work in improving the sensing and interpretation of the data is discussed in an effort to develop a robust method of quality-based, in-process monitoring of friction welds.

  5. Emotion understanding in clinically anxious children: A preliminary investigation

    DEFF Research Database (Denmark)

    Bender, Patrick Karl; Pons, Francisco; Harris, Paul L.; Esbjørn, Barbara Hoff; Reinholdt-Dunne, Marie Louise

    2015-01-01

    Children’s understanding of the nature, origins and consequences of emotions has been intensively investigated over the last 30-40 years. However, few empirical studies have looked at the relation between emotion understanding and anxiety in children and their results are mixed. The aim of the...... present study was to perform a preliminary investigation of the relationships between emotion understanding, anxiety, emotion dysregulation, and attachment security in clinically anxious children. A sample of 16 clinically anxious children (age 8-12, 8 girls/boys) was assessed for emotion understanding...... (Test of Emotion Comprehension), anxiety (Screening for Child Anxiety Related Emotional Disorders-Revised and Anxiety Disorder Interview Schedule), emotion dysregulation (Difficulties in Emotion Regulation Scale) and attachment security (Security Scale). Children who reported more overall anxiety also...

  6. Comparative clinical, roentgenological, scintigraphic and thermographic investigations in psoriasis arthropathica

    International Nuclear Information System (INIS)

    20 patients with psoriasis arthropatica and different duration of the articular symptoms were examined. Besides clinical investigation radiographs of both hands and feet (central and phalanges), scintigraphy of hands, feet and the sacroiliac joints as well as liquid crystal thermograhy of both hands were performed and the results are compared. The conclusions drawn characterize the diagnostic value of the methods. Scintigraphy as well as thermography are very good means for the early detection of psoriasis arthropathica. (author)

  7. Approximations in Inspection Planning

    DEFF Research Database (Denmark)

    Engelund, S.; Sørensen, John Dalsgaard; Faber, M. H.; Bloch, Allan

    2000-01-01

    . One of the more important of these approximations is the assumption that all inspections will reveal no defects. Using this approximation the optimal inspection plan may be determined on the basis of conditional probabilities, i.e. the probability of failure given no defects have been found by the......Planning of inspections of civil engineering structures may be performed within the framework of Bayesian decision analysis. The effort involved in a full Bayesian decision analysis is relatively large. Therefore, the actual inspection planning is usually performed using a number of approximations...... inspection. In this paper the quality of this approximation is investigated. The inspection planning is formulated both as a full Bayesian decision problem and on the basis of the assumption that the inspection will reveal no defects....

  8. Investigation into the March 28, 1979 Three Mile Island accident by Office of Inspection and Enforcement (Investigative Report No. 50-320/79-10)

    International Nuclear Information System (INIS)

    On March 28, 1979, the Three Mile Island Unit 2 Nuclear Power Plant experienced the most severe accident in U.S. commercial nuclear power plant operating history. This report sets forth the facts concerning the events of the accident determined as a result of an investigation by the NRC Office of Inspection and Enforcement. The IE investigation is limited to two aspects of the accident: (1) Those related operational actions by the licensee during the period from before the initiating event until approximately 8:00 p.m., March 28, when primary coolant flow was re-established by starting a reactor coolant pump, and (2) Those steps taken by the licensee to control the release of radioactive material to the off-site environs, and to implement his emergency plan during the period from the initiation of the event to midnight, March 30. These investigation periods were selected because they include the licensee actions which most significantly affected the accident sequence and its results

  9. Investigating inspection practices of pharmaceutical manufacturing facilities in selected Arab countries: views of inspectors and pharmaceutical industry employees.

    Science.gov (United States)

    Garg, S; Hasan, R; Scahill, S; Babar, Z Ud-Din

    2013-11-01

    There are few studies that explore inspection practices of pharmaceutical facilities from the viewpoint of inspectors and industry employees. In this descriptive, cross-sectional study, inspectors and quality assurance staff from 4 Arab countries--the United Arab Emirates, Saudi Arabia, Egypt and Jordan--were surveyed about their inspection practices and views. There was considerable variation in inspection practices across countries and between the inspectorate and quality assurance staff within countries. Divergence was found in views associated with payment mechanisms. There was mutual agreement by both groups that inspectors were in short supply and that they needed to be better trained. Inspectors appeared to have less authority than expected in order to control pharmaceutical manufacturing and marketing activities. Compounding this was a dearth of policy which would support a more uniform and systematic approach to the inspection process within and across countries. PMID:24673082

  10. Serious adverse event reporting in investigator-initiated clinical trials.

    Science.gov (United States)

    Wallace, Sophie; Myles, Paul S; Zeps, Nikolajs; Zalcberg, John R

    2016-04-01

    Reporting adverse events (AEs) and serious AEs (SAEs) are practical steps to ensure safety for volunteers and patients in medical research involving medications, treatments and devices. However, the burden and cost of reporting should be proportionate with the public health benefit of this information. Unfortunately, in Australia there is clear evidence of ever-increasing requirements from sponsors and ethics committees to report AEs and SAEs unnecessarily, leading to a decrease in the uptake of research, particularly less well funded investigator-initiated trials. We believe that individual AE reports to ethics committees serve no useful purpose, because in most cases the study group identity (drug exposure) is not known in studies with blinded treatment arms and their value is limited. Pragmatic, investigator-initiated Phase IV clinical trials of post-marketed drugs or devices are needed to understand their role in everyday clinical practice. In this setting, the workload and costs of systematic, complete reporting of all AEs and SAEs (independent of whether these are treatment-related) is wasteful, and mostly unnecessary. A trial data safety and monitoring committee is in the unique position of being able to review safety information according to the blinded treatment arms of the study. This enables safety data to be analysed appropriately and a summary report provided to the trial steering committee, principal investigators and the relevant ethics committees in a meaningful way. Defined trial endpoints do not need to be reported as safety events (because they are being properly monitored and analysed). PMID:27031396

  11. Inspection Database

    Data.gov (United States)

    U.S. Department of Health & Human Services — FDA is disclosing the final inspection classification for inspections related to currently marketed FDA-regulated products. The disclosure of this information is...

  12. Sesame seed allergy: Clinical manifestations and laboratory investigations

    Directory of Open Access Journals (Sweden)

    Fazlollahi MR.

    2007-10-01

    Full Text Available Background: Plant-origin foods are among the most important sources of food allergic reactions. An increase in the incidence of sesame seed allergy among children and adults has been reported in recent years. The aim of this preliminary study was to investigate the prevalence, importance and clinical manifestations of sesame allergy among Iranian patients.Methods: In a cross-sectional survey, 250 patients with suspected IgE-mediated food allergies completed a questionnaire and underwent skin prick tests with sesame extract as well as cross-reacting foods (walnut, soya and peanut. Total IgE and sesame-specific IgE levels were measured. Patients with positive skin test reactions and/or IgE specific for sesame without clinical symptoms were considered sensitive to sesame. The patients who also had clinical symptoms with sesame consumption were diagnosed as allergic to sesame.Results: Of the 250 patients enrolled in this study, 129 were male and 121 female, with a mean age of 11.7 years. The most common food allergens were cow's milk, egg, curry, tomato and sesame. Sesame sensitivity was found in 35 patients (14.1%. Only five patients (2% had sesame allergy. Sesame-sensitive patients had a significantly higher frequency of positive prick test to cross-reacting foods when compared to non-sensitized patients (p=0.00. The type of symptom was independent of gender and age of the patients, but urticaria and dermatitis-eczema were significantly more frequent in sensitized patients (p=0.008.Conclusions: This is the first study addressing the prevalence of sesame seed allergy in Iranian population. We found sesame to be a common and important cause of food allergy. The panel of foods recommended for use in diagnostic allergy tests should be adjusted.

  13. Basic and clinical investigation of T3 immunoassay kit

    International Nuclear Information System (INIS)

    T3 immunoassay kit was investigated basically and clinically. A good result was obtained at the prescribed incubation temperature and for 16 hours of incubation time. Moreover, it was thought to be possible that incubation time could be shortened to 1 - 4 hours at 370C. Specificity of antibody was good. Recovery of added T3 was 100+-5 (S.D.) % on an average and parallel of dilution curve of high T3 serum was also good. Variation coefficient of accuracy of this kit was 1.5 - 2.1 % and that of reproducibility was 1.3 - 6.6 %. Mild hemolysis did not affect measurement value. Serum T3 level in normals, untreated patients with Basedow's disease and patients with primary hypothyroidism was 142+-21 ng/100 ml, 452+-156 ng/100 ml and 67+-17 ng/100 ml, respectively. Serum T3 level in patients with Hashimoto's disease was distributed to a wide extent, but that of patients with goiter and simple goiter ranged within normal range. On the other side, serum T3 level of normal pregnant woman was high and that of patients with anorexia nervosa showed low level. From the above mentioned results, it was concluded that this kit was simple in method and good in sensitivity, specificity and reproducibility and it was also useful for clinical applications. (M. Tsunoda)

  14. Investigation on clinical application of CT virtual colonoscopy

    International Nuclear Information System (INIS)

    Objective: To investigate the methods, imaging features and clinical value of CT virtual colonoscopy (CTVC). Methods: Thirty one patients underwent volume scanning using helical CT (Hispeed CT/i, GE). The diseases included adenocarcinoma 25, adenomatous polyp 2, non-Hodgkin's lymphoma 1, adenosquamocarcinoma 1 multiple diverticulum 1 and mucocele of appendix 1. All cases were proved by histology except the one with multiple diverticulum. Volumetric data was acquired, and 3D virtual colonoscopy images were generated from volumetric data using the Navigator soft-ware. The CTVC images was observed along the axis of colon using the soft-ware, Fly through. Results: CTVC correctly demonstrated the detail of surface of masses. It could show the daughter nodules around the main mass, an indication of malignancy, and the normal or abnormal mucosal folds. CTVC had lower sensitivity for flat lesion. Conclusions: CTVC has proved to be a non-invasive and useful tool in the detection of space-occupying lesions of the colon. CTVC has good prospect of clinical application

  15. Biochemical Investigation Is no Substitute for Clinical Examination!

    Directory of Open Access Journals (Sweden)

    Kathryn LA Rogers

    2008-03-01

    Full Text Available Context Toxic shock syndrome has been shown previously to be associated with hyperamylasaemia. However, serum amylase levels do not usually exceed three times upper limit of normal in these cases. Case report We report a case of a young girl of 17 years who presented with upper abdominal pain, severe shock and raised serum amylase level of 3,898 U/L, giving an impression of severe acute pancreatitis. It was only after finding a tampon in her vagina, and subsequently growing Staphylococcus aureus in her blood cultures, did the diagnosis of toxic shock syndrome become apparent. She recovered fully with supportive treatment and appropriate antibiotics. Conclusions Toxic shock syndrome with such a high level of serum amylase has not been previously reported. This case exemplifies the importance of repeated clinical evaluation of patients in this era of multiple investigations, and not simply relying on biochemical values for diagnosis.

  16. Clinical Investigation of Radiation Retinopathy Fundus and Fluorescein Angiographic Features

    Institute of Scientific and Technical Information of China (English)

    LiMei; QiuGT

    1999-01-01

    Purpose:To investigate the fundus and fluorescein angiographic features in the patients with radiation retinopathy.Clinical Materials:Color fundus photography and/or fluorescein angiography from 13 patients with nasopharyngeal carcinomas received external beam radiation were retrospectively analyzed.Reslts:In this study,26 damaged eyes of 13 patients eveloped some degree of radiation retinopathy.The earliest and most common finding was macular microvascular changes (microaneurysms and/or telangiectasia),which was observed in 100%(26/26)of the eyes.Intraretinal hemorrhages,macular capillary nonperfusion,and macular edema were noted in 84%,50%,and 42% of the eyes,respectively.Conclusions:Radiation retinopathy is common after external beam radiation of nasopharyngeal carcinomas.The prominent changes include maular microvascular changes,intraretinal hemorrhages and macular capillary nonperfusion.

  17. Inspection planning

    International Nuclear Information System (INIS)

    Slovenian Nuclear Safety Administration (SNSA) division of nuclear and radiological safety inspection has developed systematic approach to their inspections. To be efficient in their efforts regarding regular and other types of inspections, in past years, the inspection plan has been developed. It is yearly based and organized on a such systematic way, that all areas of nuclear safety important activities of the licensee are covered. The inspection plan assures appropriate preparation for conducting the inspections, allows the overview of the progress regarding the areas to be covered during the year. Depending on the licensee activities and nature of facility (nuclear power plant, research reactor, radioactive waste storage, others), the plan has different levels of intensity of inspections and also their frequency. One of the basic approaches of the plan is to cover all nuclear and radiological important activities on such way, that all regulatory requests are fulfilled. In addition, the inspection plan is a good tool to improve inspection effectiveness based on previous experience and allows to have the oversight of the current status of fulfillment of planned inspections. Future improvement of the plan is necessary in the light of newest achievements on this field in the nuclear world, that means, new types of inspections are planned and will be incorporated into plan in next year.(author)

  18. Dosimetry investigation of MOSFET for clinical IMRT dose verification.

    Science.gov (United States)

    Deshpande, Sudesh; Kumar, Rajesh; Ghadi, Yogesh; Neharu, R M; Kannan, V

    2013-06-01

    In IMRT, patient-specific dose verification is followed regularly at each centre. Simple and efficient dosimetry techniques play a very important role in routine clinical dosimetry QA. The MOSFET dosimeter offers several advantages over the conventional dosimeters such as its small detector size, immediate readout, immediate reuse, multiple point dose measurements. To use the MOSFET as routine clinical dosimetry system for pre-treatment dose verification in IMRT, a comprehensive set of experiments has been conducted, to investigate its linearity, reproducibility, dose rate effect and angular dependence for 6 MV x-ray beam. The MOSFETs shows a linear response with linearity coefficient of 0.992 for a dose range of 35 cGy to 427 cGy. The reproducibility of the MOSFET was measured by irradiating the MOSFET for ten consecutive irradiations in the dose range of 35 cGy to 427 cGy. The measured reproducibility of MOSFET was found to be within 4% up to 70 cGy and within 1.4% above 70 cGy. The dose rate effect on the MOSFET was investigated in the dose rate range 100 MU/min to 600 MU/min. The response of the MOSFET varies from -1.7% to 2.1%. The angular responses of the MOSFETs were measured at 10 degrees intervals from 90 to 270 degrees in an anticlockwise direction and normalized at gantry angle zero and it was found to be in the range of 0.98 ± 0.014 to 1.01 ± 0.014. The MOSFETs were calibrated in a phantom which was later used for IMRT verification. The measured calibration coefficients were found to be 1 mV/cGy and 2.995 mV/cGy in standard and high sensitivity mode respectively. The MOSFETs were used for pre-treatment dose verification in IMRT. Nine dosimeters were used for each patient to measure the dose in different plane. The average variation between calculated and measured dose at any location was within 3%. Dose verification using MOSFET and IMRT phantom was found to quick and efficient and well suited for a busy radiotherapy

  19. Clinical dosimetry in photon radiotherapy. A Monte Carlo based investigation

    International Nuclear Information System (INIS)

    Practical clinical dosimetry is a fundamental step within the radiation therapy process and aims at quantifying the absorbed radiation dose within a 1-2% uncertainty. To achieve this level of accuracy, corrections are needed for calibrated and air-filled ionization chambers, which are used for dose measurement. The procedures of correction are based on cavity theory of Spencer-Attix and are defined in current dosimetry protocols. Energy dependent corrections for deviations from calibration beams account for changed ionization chamber response in the treatment beam. The corrections applied are usually based on semi-analytical models or measurements and are generally hard to determine due to their magnitude of only a few percents or even less. Furthermore the corrections are defined for fixed geometrical reference-conditions and do not apply to non-reference conditions in modern radiotherapy applications. The stochastic Monte Carlo method for the simulation of radiation transport is becoming a valuable tool in the field of Medical Physics. As a suitable tool for calculation of these corrections with high accuracy the simulations enable the investigation of ionization chambers under various conditions. The aim of this work is the consistent investigation of ionization chamber dosimetry in photon radiation therapy with the use of Monte Carlo methods. Nowadays Monte Carlo systems exist, which enable the accurate calculation of ionization chamber response in principle. Still, their bare use for studies of this type is limited due to the long calculation times needed for a meaningful result with a small statistical uncertainty, inherent to every result of a Monte Carlo simulation. Besides heavy use of computer hardware, techniques methods of variance reduction to reduce the needed calculation time can be applied. Methods for increasing the efficiency in the results of simulation were developed and incorporated in a modern and established Monte Carlo simulation environment

  20. Clinical classification of chronic prostatitis: a preliminary investigation

    Institute of Scientific and Technical Information of China (English)

    Wei-DongHUANG; PeiLIU; Wen-JieHUANG

    2000-01-01

    Aim: To propose a practical clinical classification for the chronic prostatitis (CP). Methods: The clinical features and the findings in the expressed prostatic secretion (EPS) in 804 cases of CP patients were retrospectively analyzed. Results: Four types of CP were identified based on the clinical manifestations and the amounts of white blood cells (WBC) and lecithin in EPS. They were the latent type (85 cases; 10.6%), the common type (423 cases;52.6%), the persisting type (104 cases; 12.9%), and the active type (192 cases, 23.9%). The therapeutic efficacy for these 4 subtypes were 40.4%, 76.8%, 30.8% and 37%, respectively; a statistical difference was noticed between the common type and the persisting type (P<0.01). Conclusion: The method of classification proposed by the authors may help clinicians in the diagnosis and predicting the prognosis of CP. (Asian J Androl 2000 Dec;2:311-313)

  1. 76 FR 1173 - Draft Guidance for Industry on Electronic Source Documentation in Clinical Investigations...

    Science.gov (United States)

    2011-01-07

    ...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled ``Electronic Source Documentation in Clinical Investigations.'' This document provides guidance to sponsors, contract research organizations (CROs), data management centers, and clinical investigators on capturing, using, and archiving electronic data in FDA-regulated clinical......

  2. Hospital Inspections

    Data.gov (United States)

    U.S. Department of Health & Human Services — Welcome to hospitalinspections.org, a website run by the Association of Health Care Journalists (AHCJ) that aims to make federal hospital inspection reports easier...

  3. A Short Version of the Revised ‘Experience of Close Relationships Questionnaire’: Investigating Non-Clinical and Clinical Samples

    OpenAIRE

    Wongpakaran, Tinakon; Wongpakaran, Nahathai

    2012-01-01

    Aim: This study seeks to investigate the psychometric properties of the short version of the revised ‘Experience of Close Relationships’ questionnaire, comparing non-clinical and clinical samples. Methods: In total 702 subjects participated in this study, of whom 531 were non-clinical participants and 171 were psychiatric patients. They completed the short version of the revised ‘Experience of Close Relationships’ questionnaire (ECR-R-18), the Perceived Stress Scale-10(PSS-10), the Rosenberg ...

  4. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  5. A clinical neuroscience investigation into flashbacks and involuntary autobiographical memories

    OpenAIRE

    Clark, Ian Alexander; Holmes, Emily A.; Mackay, Clare E.

    2013-01-01

    Recurrent and intrusive distressing recollections of trauma are a hallmark symptom of Posttraumatic Stress Disorder (PTSD). The term ‘flashback’ is used in this thesis to refer to vivid, sensory perceptual (predominantly visual images), emotional memories from a traumatic event that intrude involuntarily into consciousness. Furthermore, intrusive image based memories occur in a number of other psychological disorders, for example, bipolar disorder and depression. Clinically, the presence and ...

  6. Investigation of Tinnitus Patients in Italy: Clinical and Audiological Characteristics

    OpenAIRE

    Francesco Martines; Daniela Bentivegna; Fabiola Di Piazza; Enrico Martines; Vincenzo Sciacca; Gioacchino Martinciglio

    2010-01-01

    Objective. 312 tinnitus sufferers were studied in order to analyze: the clinical characteristics of tinnitus; the presence of tinnitus-age correlation and tinnitus-hearing loss correlation; the impact of tinnitus on subjects' life and where possible the etiological/predisposing factors of tinnitus. Results. There is a slight predominance of males. The highest percentage of tinnitus results in the decades 61–70. Of the tinnitus sufferers, 197 (63.14%) have a hearing deficit (light hearing loss...

  7. Clinical and laboratory investigation of experimentaly infected broilers with CIAV

    Directory of Open Access Journals (Sweden)

    Kapetanov Miloš C.

    2004-01-01

    Full Text Available Chicken infectious anemia (CIA is widespread viral disease in countries with the intensive poultry industry. In susceptible birds CIAV causes anemia subcutaneous and intramuscular hemorrhages, lymphoid tissue atrophy immunosuppression, cachexia and increased mortality. Protection of progeny relies not only on age resistance but also on maternally delivered antibodies (Mabs so possessing the information on level and persistence of Mabs is of great significance. In our study experimental infection with CIAV was performed on one and seven days old broiler chickens from naturally infected parent flock during the rearing period. In infected birds, clinical signs hematological findings and humoral immune response were examined. After euthanasia, we looked for specific pathomorphological and histopathological changes that indicate the presence of CIAV infection. In all one and seven days old chickens maternally derived antibodies were established. No clinical signs of CIA were observed, hematological findings showed no deviation from referent values, and there were no specific pathomorphological and histopathological changes at postmortem examination. According to previous knowledge, only serological negative flock if infected in time of laying represent risk for vertical transmission to progeny where typical disease with mortality will appear. The absence of Mabs in one day old chickens is critical point in break of disease. Typical clinical picture in day old chickens rises only when vertical transmission occurs.

  8. Automated radiosynthesis of [11C]morphine for clinical investigation

    International Nuclear Information System (INIS)

    To meet a multiple-dose clinical evaluation of the P-gp modulation of [11C]morphine delivery into the human brain, radiosynthesis of [11C]morphine was accomplished on an automated system by N-methylation of normorphine with [11C]CH3I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45 min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26 Ci/μmol (decay corrected to end-of-bombardment); radiochemical and chemical purities were >95% (n=28).

  9. Inspection and teachers’ emotions: An emotional evaluation of inspection

    Directory of Open Access Journals (Sweden)

    Binali Tunç

    2015-02-01

    Full Text Available In the study, inspection is discussed in relation to the teachers’ feelings and emotions it creates before inspection, during inspection and after inspection process. Teacher’s emotions have been investigated intentionally as emotional side of education has been neglected. Education is closely related to the emotions of teachers, who are the most important producers of educational activities.Educational activities are reduced to standard activities and defined with simple explanations or single labels such as ‘good-bad’, ‘successful-unsuccessful’, ‘adequate-inadequate’. Inspection causes emotions to be neglected. Moreover, recently, it has been discussed that there are approaches and systems that suggest constant and multi-dimensional inspection instead of traditional inspection.Qualitative research model was used to understand of teacher emotions. A semi structured form was used for the 38 primary school teachers’ interviews. After teacher interviews were completed, we analyzed and compared the interviews. Participants’ expressions were checked in terms of correctness, potential validity and reliability problems such as misinterpretation.   The results of the study can be summarized as follows: There were no positive expressions related to the emotional impact of inspection on teachers. In addition, teachers felt that the inspectors were stressed, anxious, uneasy, accusatory, coercive, looking for defect and areas of unsuccessful teaching performance. Most of teachers reported that being observed and evaluated caused them to have negative emotions.Teachers’ perceptions about inspection are found to be negative. There are no statements that indicate there is a positive impression of inspection on teachers. The emotions that are experienced before inspection: pressure, hurry, stress, concern, tension, anxiety, worry, uncertainty; during inspection: stress, tension, anger, loss of strength, humiliation and lack of self

  10. Clinical value of isotope methods in adrenal morphology investigations

    International Nuclear Information System (INIS)

    In the years 1976-1980 in 105 patients 124 adrenal scintigrams were obtained, including 50 in patients with primary hyperaldosteronism syndrome, 27 with Cushings syndrome, 8 after bilateral total adrenalectomy, 4 with adrenal virilizing tumours, 6 with phaeochromocytoma, 10 with normal adrenal function. The results of scintigraphy were compared with those of arteriography, phlebography, computer tomography and postoperative findings. The clinical value of scintigraphy was found to be greatest in cases of adrenocortical disease. In cases of phaeochromocytoma isotope angioscintigraphy is a useful method for localizing the tumour since it makes possible demonstration of the vascular bed of the tumour. A close correlation was demonstrated between the results of scintigraphy and those of computer tomography. In the group of 27 patients treated surgically for adrenocortical disease in 87% of cases an agreement was found between the results of scintigraphy and the result of the operation. For different adrenocortical diseases this per cent was: 77% for Cushings syndrome, 91% for primary hyperaldosteronism, 100% for adrenal virilizing tumours. The study showed that adrenal scintigraphy is a very valuable diagnostic method of high clinical usefulness in adrenocortical diseases. (author)

  11. Beecher as Clinical Investigator: Pain and the Placebo Effect.

    Science.gov (United States)

    Benedetti, Fabrizio

    2016-01-01

    Among the many contributions by Henry Beecher to science and clinical practice, pain and the placebo effect certainly represent two of the most important aspects. On the one hand, Beecher considered the pain experience not only as arising from the peripheral injured tissues, but also as an emotional experience that is capable of modulating the nociceptive input. On the other hand, he analyzed the placebo effect at an unprecedented level for that time. His ideas sparked from his work on wounded soldiers during World War II. In spite of the unusual situation and the lack of sophisticated experimental tools on the battlefield, Beecher succeeded in putting forward several important concepts, and his ideas still pervade modern health care and research. PMID:27499483

  12. An Investigation of Clinically Significant Change Among Clients of a Doctoral Psychology Training Clinic

    OpenAIRE

    Prout, Kerry Kathleen

    2013-01-01

    The current study sought to examine client outcome data for clients seen for outpatient psychotherapy services by graduate-level student therapists in doctoral psychology training clinics in order to better understand the change process occurring in such settings and to examine whether services being offered are meaningful for clients. One hundred ninety-nine clients seen by graduate-level therapists at a training clinic setting were assessed on a session-by-session basis using the Outcome Qu...

  13. Investigation of Tinnitus Patients in Italy: Clinical and Audiological Characteristics

    Directory of Open Access Journals (Sweden)

    Francesco Martines

    2010-01-01

    Full Text Available Objective. 312 tinnitus sufferers were studied in order to analyze: the clinical characteristics of tinnitus; the presence of tinnitus-age correlation and tinnitus-hearing loss correlation; the impact of tinnitus on subjects' life and where possible the etiological/predisposing factors of tinnitus. Results. There is a slight predominance of males. The highest percentage of tinnitus results in the decades 61–70. Of the tinnitus sufferers, 197 (63.14% have a hearing deficit (light hearing loss in 37.18% of cases. The hearing impairment results of sensorineural type in 74.62% and limited to the high frequencies in 58.50%. The tinnitus is referred as unilateral in 59.93%, a pure tone in 66.99% and 10 dB above the hearing threshold in 37.7%. It is limited to high frequencies in 72.10% of the patients with sensorineural hearing loss (SNHL while the 88.37% of the patients with high-frequency SNHL have a high-pitched tinnitus (2=66.26;<.005. Conclusion. Hearing status and age represent the principal tinnitus related factors; there is a statistically significant association between high-pitched tinnitus and high-frequency SNHL. There is no significant correlation between tinnitus severity and tinnitus loudness confirming the possibility that neural connection involved in evoking tinnitus-related negative reactions are governed by conditioned reflexes.

  14. Inspection scheme

    International Nuclear Information System (INIS)

    As part of the Danish RERTR Program, three fuel elements with LEU U3O8-Al fuel and three fuel elements with LEU U3Si2-Al fuel were manufactured by NUKEM for irradiation testing in the DR-3 reactor at the Risoe National Laboratory in Denmark. The inspection scheme for the elements with U3O8-Al fuel is presented here as an illustration only. The inspection scheme for the elements with U3Si2-Al fuel was very similar. In this example, all document numbers, drawing numbers, and form numbers have been deleted or replaced with a generic identification. (author)

  15. [The Clinical Investigation Centers in France: Whatzat? What for? How does it work?

    OpenAIRE

    Montagne, Olivier; Le Corvoisier, Philippe

    2008-01-01

    International audience For the last 15 years, French university-affiliated hospitals have dramatically modified how biomedical research is conducted in France. Multidisciplinary and technically complex research projects are increasingly difficult to conduct in clinical units. To ensure quality, good clinical practice, and security, platforms dedicated to clinical research with specific staff have been implanted. These units, called Clinical Investigation Centers (CICs), are open to academi...

  16. 77 FR 69632 - Draft Guidance for Industry on Electronic Source Data in Clinical Investigations; Availability

    Science.gov (United States)

    2012-11-20

    ...The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled ``Electronic Source Data in Clinical Investigations.'' This document revises and updates the draft guidance entitled ``Electronic Source Documentation in Clinical Investigations.'' This revised draft document provides guidance to sponsors, contract research organizations (CROs), data......

  17. 76 FR 30175 - Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by...

    Science.gov (United States)

    2011-05-24

    ... HUMAN SERVICES Food and Drug Administration (Formerly FDA-1999-D-0792) Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by Clinical Investigators; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  18. 78 FR 13070 - Guidance for Clinical Investigators, Industry, and Food and Drug Administration Staff: Financial...

    Science.gov (United States)

    2013-02-26

    ... HUMAN SERVICES Food and Drug Administration (formerly 1999D-4396) Guidance for Clinical Investigators, Industry, and Food and Drug Administration Staff: Financial Disclosure by Clinical Investigators....) In the Federal Register of May 24, 2011 (76 FR 30175), FDA announced the availability of the...

  19. Clinical and Laboratory Investigation of Oral Allergy Syndrome to Grape

    Directory of Open Access Journals (Sweden)

    Reza Falak

    2012-06-01

    Full Text Available Oral allergy syndrome (OAS is occasionally observed following consumption  of raw fruits  in  allergic adults. Since this  phenomenon  was  commonly  reported  in  Khorasan province of Iran; we intended to check if common  diagnostic tests could be applied for differential diagnosis of OAS to grapes.IgE reactivity of 84 patients with OAS to grape and 34 patients with OAS to other fruits were analyzed by in vivo and in vitro methods, and the results were compared with those of controls. The patients underwent skin prick test (SPT with common allergic pollen extracts as well as grape extract. The specific IgE  level to grape proteins was determined by an indirect ELISA. The correlation of SPT results with ELISA and western blotting patterns was checked by statistical methods.The results showed a significant correlation of grape SPT diameters with grape specific IgE levels. Furthermore,  a significant association of grape SPT results with IgE immunoreactivity of a 10 kDa  grape protein,  probably lipid transfer protein  (LTP was prominent. Immunoreactivity of other proteins was linked with mild clinical symptoms.The study showed a significant correlation of grape SPT results with grape total extract, as well as its 10 kDa component’s IgE reactivity. The results suggested that OAS to grape should not be considered as a main criterion in diagnosis of grape allergy and a combination of grape SPT results with evaluation of IgE reactivity to grape 10 kDa allergen should be considered to achieve a more reliable grape allergy diagnosis.

  20. Patient engagement: an investigation at a primary care clinic

    Directory of Open Access Journals (Sweden)

    Gill PS

    2013-03-01

    Full Text Available Preetinder Singh Gill College of Technology, Eastern Michigan University, Ypsilanti, MI, USA Background: Engaged employees are an asset to any organization. They are instrumental in ensuring good commercial outcomes through continuous innovation and incremental improvement. A health care facility is similar to a regular work setting in many ways. A health care provider and a patient have roles akin to a team leader and a team member/stakeholder, respectively. Hence it can be argued that the concept of employee engagement can be applied to patients in health care settings in order to improve health outcomes. Methods: Patient engagement data were collected using a survey instrument from a primary care clinic in the northern Indian state of Punjab. Canonical correlation equations were formulated to identify combinations which were strongly related to each other. In addition, the cause-effect relationship between patient engagement and patient-perceived health outcomes was described using structural equation modeling. Results: Canonical correlation analysis showed that the first set of canonical variables had a fairly strong relationship, ie, a magnitude > 0.80 at the 95% confidence interval, for five dimensions of patient engagement. Structural equation modeling analysis yielded a β ≥ 0.10 and a Student's t statistic ≥ 2.96 for these five dimensions. The threshold Student's t statistic was 1.99. Hence it was found the β values were significant at the 95% confidence interval for all census regions. Conclusion: A scaled reliable survey instrument was developed to measured patient engagement. Better patient engagement is associated with better patient-perceived health outcomes. This study provides preliminary evidence that patient engagement has a causal relationship with patient-perceived health outcomes. Keywords: patient engagement, health outcomes, communication, provider effectiveness, patient incentive

  1. Ball screw inspection setup

    Science.gov (United States)

    Janusz, Rzepka; Sambor, Slawomir; Pienkowski, Janusz; Bielenin, Marcin

    2003-05-01

    In the following paper we describe arrangements of laser interferometer for investigation of screws and for inspection of ball screws. We have constructed two of them, namely: the technological setup for investigations of screw in process of production and the ball screw inspection setup. The former one is used to measure the pitch of screws. The data gathered during measurement is used to calculate the parameters for grinding machine. The later setup is used for testing parameters of complete ball screws. The software supporting this setup makes calculation of parameters of tested ball screw and creation of reports possible. Additionally, the inspection setup is the one that the torque measuring arrangements have been integrated on. Both the arrangements and the software allow for measurements of all parameters during movement of nut in full travel length of the ball screw and make charts and reports.

  2. Factors associated with regulatory action involving investigation of illnesses associated with Shiga toxin-producing Escherichia coli in products regulated by the Food Safety and Inspection Service.

    Science.gov (United States)

    Green, Alice L; Seys, Scott; Douris, Aphrodite; Levine, Jeoff; Robertson, Kis

    2014-07-01

    We described characteristics of the Escherichia coli O157 and Escherichia coli non-O157 illness investigations conducted by the United States Department of Agriculture's Food Safety and Inspection Service (FSIS) during the 5-year period from 2006 through 2010. We created a multivariable logistic regression model to determine characteristics of these investigations that were associated with FSIS regulatory action, which was defined as having occurred if a product recall occurred or if FSIS personnel performed an environmental health assessment (Food Safety Assessment) at the implicated establishment. During this period, FSIS took regulatory action in 38 of 88 (43%) investigations. Illness investigations in which FoodNet states were involved were more likely to result in regulatory action. Illness investigations in which state and local traceback, or FSIS traceback occurred were more likely to result in regulatory action. Reasons for lack of action included evidence of cross-contamination after the product left a regulated establishment, delayed notification, lack of epidemiological information, and insufficient product information. PMID:24826872

  3. Clinical investigation on application of water swallowing to MR esophagography

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jinping, E-mail: zjpmri@163.com [Department of Radiology, Tongling People' s Hospital, Bijiashan Road 468, Tongling 244000, Anhui (China); Hu, Weijian; Zang, Lin [Department of Cardiothoracic Surgery, Tongling People' s Hospital, Bijiashan Road 468, Tongling 244000, Anhui (China); Yao, Yibin; Tang, Yongxiang; Qian, Zhen; Gao, Ping; Wu, Xiaoyan; Li, Shijian [Department of Radiology, Tongling People' s Hospital, Bijiashan Road 468, Tongling 244000, Anhui (China); Xie, Zhenlan; Yuan, Xiaoqing [Department of Pathology, Tongling People' s Hospital, Bijiashan Road 468, Tongling 244000, Anhui (China)

    2012-09-15

    Objective: To verify the clinical outcomes of applying water swallowing to MR esophagography. Methods: Thirty patients confirmed postoperatively or histopathologically with thoracic esophageal carcinoma by endoscopic biopsy and 10 healthy volunteers with normal esophagus underwent respectively conventional magnetic resonance imaging (MRI) detection and water swallowing MR esophagography. Of those patients, 4 underwent second examination after radiotherapy. Assessment on imaging effects of MR esophagography was performed. Assessment on definition on MR esophagography of the tumor in both upper and lower ends, specific localization, tumor size finally measured, coincidence with the gross pathologic types and tumor staging were respectively performed by comparison with conventional MRI. Additionally, we evaluated the outcomes of radiotherapy by comparing the previous MR esophagography with the second one with interventional technique. Results: Of the total 44 images of MR esophagography, 97.7% (43/44) were in high resolution by sagittal view and 81.8% (36/44) by cross-section. 93.3% (56/60) of the MR esophagography were clearly defined with the neoplastic lesion ends in the 30 patients with thoracic esophageal carcinoma, compared with 11.7% (7/60) by conventional MRI. The results were totally different in statistics (P < 0.005). Preoperative conventional MRI detection of the 22 cases in 25 undergone radical resection suggested vague diameter of the primary tumor and impossibly identified it at middle-lower thoracic esophagus in 5, and even failed to confirm gross pathologic types in 19 cases. Yet, MR esophagography with water swallowing represented accurate tumor length (graded as excellent) in 88% (22/25), localization in 100% (25/25), exact gross pathologic types in 88% (22/25), and accuracy for tumor staging in 80.8% (21/26) compared to 92.3% (24/26) by conventional MRI. Therapeutic effects achieved in 4 patients with radiotherapy. Conclusions: MR esophagography

  4. Clinical and morphological investigations on ependymomas and their tissue cultures.

    Science.gov (United States)

    Casentini, L; Gullotta, F; Möhrer, U

    1981-03-01

    A morphological investigation was carried out on 56 ependymomas cultivated in vitro as short-term cultures in roller tubes. The tumours had been histologically classified as cellular and fibrillary ependymomas, subependymomas, myxopapillary and malignant ependymomas (Table 1). A very good growth was detected in 32 cases, most of them being cellular and malignant ependymomas (Table 2). The prevailing growth pattern was epithelial in type, i.e. proliferating cells forming a carpet. In some cases, in the first stages of growth elongated bipolar cells did appear, but they evolved later as flattened epithelial elements. In four cases, a mixed proliferation of piloid astrocytes and ependymal cells was seen; these tumours were regarded as mixed gliomas. In 46 cases an exact evaluation of the history was possible. Although no correlation could be found between histology and survival time (Table 4), the longest survival was observed in spinal tumours (Table 3). Tumours in children had a slightly worse prognosis in comparison with adults (Table 5). A radical removal of the tumour was generally followed by a longer survival time (Table 6), although the operative procedure employed did not seem to influence the development of recurrences (Table 7). PMID:7219656

  5. A facilitative versus directive approach in training clinical skills? Investigating students’ clinical performance and perceptions

    OpenAIRE

    Berghmans, Inneke; Druine, Nathalie; Dochy, Filip; Struyven, Katrien

    2012-01-01

    Over the years, many medical school curricula have started implementing diverse student-centred teaching and learning methodologies. Previous studies, however, have indicated that students prefer more traditional and directive methodologies instead, raising questions on which training approach should be advocated. This study contrasts the effects of a student-centred (i.e. facilitative) training approach on students’ clinical skills learning with students’ perceptions. More specifically, a qu...

  6. Aetiologic, Clinical and Roentgenographic Investigations on 75 Cases of Hip Arthrosis

    OpenAIRE

    Yucel, Kamuran

    2004-01-01

    75 cases of hip arthrosis who have applied to our clinic have been evaluated, symptomatological and radiographic examinations have been performed, and the findings obtained have been compared with the findings determined by the other investigators.

  7. EM-GE-5 Regulation. Standard for the first-rate application clinical practices in the execution of the clinical investigations for medical teams' evaluation

    International Nuclear Information System (INIS)

    This guide has the following objectives: a) To guide methodologically the implementation of Good Clinical Practice for the execution of clinical research with medical devices that need to be evaluated, in addition to the Regulation ER-6. Requirements for the Conduct of Clinical Trials for Medical Devices , b) Provide the fundamental aspects to be taken into count for quality control to clinical investigations.

  8. Visual inspection for CTBT verification

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, W.; Wohletz, K.

    1997-03-01

    On-site visual inspection will play an essential role in future Comprehensive Test Ban Treaty (CTBT) verification. Although seismic and remote sensing techniques are the best understood and most developed methods for detection of evasive testing of nuclear weapons, visual inspection can greatly augment the certainty and detail of understanding provided by these more traditional methods. Not only can visual inspection offer ``ground truth`` in cases of suspected nuclear testing, but it also can provide accurate source location and testing media properties necessary for detailed analysis of seismic records. For testing in violation of the CTBT, an offending party may attempt to conceal the test, which most likely will be achieved by underground burial. While such concealment may not prevent seismic detection, evidence of test deployment, location, and yield can be disguised. In this light, if a suspicious event is detected by seismic or other remote methods, visual inspection of the event area is necessary to document any evidence that might support a claim of nuclear testing and provide data needed to further interpret seismic records and guide further investigations. However, the methods for visual inspection are not widely known nor appreciated, and experience is presently limited. Visual inspection can be achieved by simple, non-intrusive means, primarily geological in nature, and it is the purpose of this report to describe the considerations, procedures, and equipment required to field such an inspection.

  9. Clinical research: business opportunities for pharmacy-based investigational drug services.

    Science.gov (United States)

    Marnocha, R M

    1999-02-01

    The application by an academic health center of business principles to the conduct of clinical research is described. Re-engineering of the infrastructure for clinical research at the University of Wisconsin and University of Wisconsin Hospital and Clinics began in 1990 with the creation of the Center for Clinical Trials (CCT) and the restructuring of the investigational drug services (IDS). Strategies to further improve the institution's clinical research activities have been continually assessed and most recently have centered on the adaptation of a business philosophy within the institution's multidisciplinary research infrastructure. Toward that end, the CCT and IDS have introduced basic business principles into operational activities. Four basic business concepts have been implemented: viewing the research protocol as a commodity, seeking payment for services rendered, tracking investments, and assessing performance. It is proposed that incorporation of these basic business concepts is not only compatible with the infrastructure for clinical research but beneficial to that infrastructure. The adaptation of a business mindset is likely to enable an academic health center to reach its clinical research goals. PMID:10030512

  10. Investigating the genetic background of bovine digital dermatitis using improved definitions of clinical status.

    Science.gov (United States)

    Schöpke, K; Gomez, A; Dunbar, K A; Swalve, H H; Döpfer, D

    2015-11-01

    Bovine digital dermatitis (DD) is an increasing claw health problem in all cattle production systems worldwide. The objective of this study was to evaluate the use of an improved scoring of the clinical status for DD via M-scores accounting for the dynamics of the disease; that is, the transitions from one stage to another. The newly defined traits were then subjected to a genetic analysis to determine the genetic background for susceptibility to DD. Data consisted of 6,444 clinical observations from 729 Holstein heifers in a commercial dairy herd, collected applying the M-score system. The M-score system is a classification scheme for stages of DD that allows a macroscopic scoring based on clinical inspections of the bovine foot, thus it describes the stages of lesion development. The M-scores were used to define new DD trait definitions with different complexities. Linear mixed models and logistic models were used to identify fixed environmental effects and to estimate variance components. In total, 68% of all observations showed no DD status, whereas 11% were scored as infectious for and affected by DD, and 21% of all observations exhibited an affected but noninfectious status. For all traits, the probability of occurrence and clinical status were associated with age at observation and period of observation. Risk of becoming infected increased with age, and month of observation significantly affected all traits. Identification of the optimal month concerning DD herd status was consistent for all trait definitions; the last month of the trial was identified. In contrast, months exhibiting the highest least squares means of transformed scores differed depending on trait definition. In this respect, traits that can distinguish between healthy, infectious, and noninfectious stages of DD can account for the infectious potential of the herd and can serve as an alert tool. Estimates of heritabilities of traits studied ranged between 0.19 (±0.11) and 0.52 (±0

  11. Using Hermeneutic Phenomenology to Investigate How Experienced Practitioners Learn to Communicate Clinical Reasoning

    Science.gov (United States)

    Ajjawi, Rola; Higgs, Joy

    2007-01-01

    This paper is primarily targeted at doctoral students and other researchers considering using hermeneutic phenomenology as a research strategy. We present interpretive paradigm research designed to investigate how experienced practitioners learn to communicate their clinical reasoning in professional practice. Twelve experienced physiotherapy…

  12. 78 FR 57395 - Guidance for Industry on Electronic Source Data in Clinical Investigations; Availability

    Science.gov (United States)

    2013-09-18

    ... ``Electronic Source Data in Clinical Investigations.'' This document provides guidance to sponsors, contract... accurate and complete data. In the Federal Register of November 20, 2012 (77 FR 69632), FDA issued a draft... FR 76049)). Most of the comments sought clarification on the topics discussed in the guidance....

  13. NAA TECHNIQUE FOR CLINICAL INVESTIGATION OF MICE IMMUNIZED WITH BOTHROP VENOM

    International Nuclear Information System (INIS)

    In the present study Neutron Activation Analysis (NAA) technique was used to determine sodium concentration in whole blood of mice immunized with Bothrops venom. With this value it was possible to perform clinical investigation in this animal model using whole blood.

  14. Methods and technique of roentgenoradionuclide investigations of gallbladder and biliary tract. Characteristics of clinical materials

    International Nuclear Information System (INIS)

    Methods for X-ray radionuclide investigation of gallbladder and biliary tracts-peroral, intravenous and infusion cholecystocholangiography, tomocholecystography, γ-scintigraphy, as well as pharmacologic contrast substances used in the methods given, are described. The characteristic of clinical material is presented

  15. Utilization of real-time x-radiography for in-service inspection of nuclear reactor piping: feasibility investigation. Final report

    International Nuclear Information System (INIS)

    The objective of this program is to determine the feasibility of Real-Time Radiographic imaging for in-service inspection of stainless steel Boiling Water Reactor (BWR) piping for detection of stress corrosion cracking. The program consisted of Real-Time Radiographic (RTR) inspection of two 4-inch diameter schedule 80 BWR pipes which were obtained from General Electric. One sample pipe was specially machined with slots of known dimensions to determine the absolute sensitivity of the real time system. The second pipe, which contained actual intergranular stress corrosion cracks, was inspected to determine the relative sensitivity of real time compared to a fine grain x-ray film (Eastman Kodak AA). The pipes were inspected with and without water to simulate actual in-service conditions and to determine if the water affected the crack detection sensitivity. The results of the study indicated that the real-time radiography system could resolve simulated cracks .008 inch wide, .030 inch deep, and .010 inch wide, .015 inch deep

  16. Presentation and clinical investigation of mitochondrial respiratory chain disease. A study of 51 patients.

    Science.gov (United States)

    Jackson, M J; Schaefer, J A; Johnson, M A; Morris, A A; Turnbull, D M; Bindoff, L A

    1995-04-01

    Defects of the mitochondrial respiratory chain are associated with a great variety of clinical disorders. Whilst recognition of these conditions is increasing, the need for sophisticated biochemical and molecular studies has tended to limit both their investigation and diagnosis to a few specialist centres. Using a group of 51 patients with histochemically, biochemically and/or genetically defined respiratory chain defects, we have examined both the clinical heterogeneity of these disorders and how they may be investigated most effectively in non-specialist centres. We evaluated the use of the following routinely available clinical investigations--fasting intermediary metabolites (lactate, pyruvate, ketone bodies, etc.) in blood and cerebrospinal fluid, serum creatine kinase estimation, EMG, EEG, CT, MRI and histological/histochemical muscle biopsy analysis. Our studies show that, in addition to well-recognized syndromes (e.g. chronic progressive external ophthalmoplegia, mitochondrial encephalopathy lactic acidosis and stroke like episodes, and myoclonus epilepsy with ragged red-fibres, a significant number of patients present with non-specific encephalopathic disorders. Furthermore, even within those categories of respiratory chain disease which have been genetically defined, a wide variation of presenting symptoms and signs were found. Where there was initial doubt concerning the diagnosis, the following clinical features were helpful in suggesting respiratory chain disease: ophthalmoplegia; a maternal pattern of inheritance; the presence of myopathy or deafness in association with encephalopathy. Of the clinical investigations we assessed, elevated lactate in blood or cerebrospinal fluid and low density lesions in the basal ganglia were helpful in identifying patients with respiratory chain dysfunction. Histochemical analysis of muscle was, however, the single most useful investigation being diagnostic in patients with chronic progressive external

  17. Inspections in veterinary medicine 2005

    International Nuclear Information System (INIS)

    In Sweden 300 veterinary clinics have a license for x-ray diagnostics. Six of them also have a license for nuclear medicine. During 2005 eight clinics were inspected and the results show that the radiation protection in veterinary medicine can be improved. No clinic fulfilled the regulations of categorization of workplaces and workers (SSI FS 1998:3). Half of the clinics had no Swedish manual to the x-ray equipment and just as many had not performed the annual function check. Obviously, there is a need for more information to staff in veterinary medicine

  18. PHENOTYPIC INVESTIGATION OF VIRULENCE PROFILES IN SOME CANDIDA SPP. STRAINS ISOLATED FROM DIFFERENT CLINICAL SPECIMENS

    Directory of Open Access Journals (Sweden)

    Alina Maria Holban

    2012-09-01

    Full Text Available Candida species great versatility may explain their wide range of infections occurred in a great variety of hosts. Even though many modern molecular techniques arise, phenotypic assays still provide valuable information and can guide the diagnosis and the treatment of infections. The phenotypic investigation of virulence determinants in some recent nosocomial isolates of Candida spp. revealed that the fungal clinical strains may develop specific virulence profiles depending on the taxonomic affiliation of the tested strains and the source of infection. Our data support the usefulness of phenotypic assays in predicting the clinical outcome of the fungal infections and in the adjustment of the antifungal treatment.

  19. Methodological problems with clinical functional MRI investigations; Methodische Probleme klinischer funktioneller MRT-Untersuchungen

    Energy Technology Data Exchange (ETDEWEB)

    Foki, T.; Beisteiner, R. [Medizinische Universitaet Wien, AG Klinische fMRT, Universitaetsklinik fuer Neurologie, Exzellenzzentrum Hochfeld-MR, Wien (Austria)

    2010-02-15

    During presurgical diagnostics clinical functional magnetic resonance imaging is increasingly being performed to improve the management of epilepsy and tumor patients. Rapid technical developments in fMRI technology continuously further new diagnostic applications. Safe clinical application requires a profound and critical handling of the various methodological problems inherent with this complex technique. This article reviews relevant problems and solutions for patient investigations up to the preparation of an individual clinical fMRI report. (orig.) [German] Die klinische funktionelle Magnetresonanztomographie (fMRT) hat als individuelles Untersuchungsverfahren v. a. in der praeoperativen Diagnostik bei Epilepsie- und Tumorpatienten einen zunehmenden Stellenwert, da sie hier zu einer klinischen Entscheidung beitragen kann. Die rasche Entwicklung der fMRT-Technologie eroeffnet dabei kontinuierlich neue diagnostische Moeglichkeiten, erfordert aber auch einen kritischen Umgang mit den zahlreichen methodischen Problemen dieses komplexen Verfahrens. Dieser Artikel beschreibt patientenrelevante Probleme und Loesungsmoeglichkeiten von der Untersuchung bis zur Erstellung des individuellen fMRT-Befundes. (orig.)

  20. Realization by inspection

    OpenAIRE

    Rosenthal, J.; Schumacher, Hans

    1997-01-01

    We investigate which first-order representations can be obtained from high-order representations of linear systems “by inspection”, that is, just by rearrangement of the data. Under quite weak conditions it is possible to obtain minimal realizations in the so-called pencil form; under stronger conditions one can obtain minimal realizations in standard state-space form by inspection. The development is based on a reformulation of the realization problem as a problem of finding a complete set o...

  1. An investigation of the relationship between functional impairment and autistic traits in a clinical population

    OpenAIRE

    Varrall, R.

    2011-01-01

    Aims: Based on theories of dimensionality and fractionation of the autistic triad, this study investigates the role of autistic traits in adaptive functioning. The suitability of current diagnostic thresholds and classification criteria are explored with particular interest in partial and mild sub-threshold autistic presentations. Method: Seventy-two young people (mean age = 11.03 years), referred for assessment at a specialist autism spectrum disorder (ASD) clinic were administered the Vinel...

  2. Clinical and genetic investigation of families with type II Waardenburg syndrome

    OpenAIRE

    Chen, Yong; YANG, FUWEI; ZHENG, HEXIN; Zhou, Jianda; ZHU, GANGHUA; HU, PENG; Wu, Weijing

    2016-01-01

    The present study aimed to investigate the molecular pathology of Waardenburg syndrome type II in three families, in order to provide genetic diagnosis and hereditary counseling for family members. Relevant clinical examinations were conducted on the probands of the three pedigrees. Peripheral blood samples of the probands and related family members were collected and genomic DNA was extracted. The coding sequences of paired box 3 (PAX3), microphthalmia-associated transcription factor (MITF),...

  3. GCP inspections in Germany and Europe following the implementation of the Directive 2001/20/EC

    Directory of Open Access Journals (Sweden)

    Hundt, Ferdinand

    2009-03-01

    Full Text Available Background: The implementation of the Clinical Trials Directive 2001/20/EC and the Good Clinical Practice Directive 2005/28/EC fundamentally restructured and harmonized the conduct of clinical trials in Europe. GCP inspections – which affect study sites, laboratories, sponsors and contract research organizations (CRO alike – make up an important part of these regulations. A common understanding of how these regulations apply in daily life is however not always ensured. Methods: A working group of the Clinical Research/Quality Assurance subcommittee of the German Association of Research-Based Pharmaceutical Companies (VFA was established to outline the regulatory requirements, the experience gathered with inspections by means of a survey and to set up guidance on how to manage an inspection. Results and conclusions: The survey, conducted with the help of 15 pharmaceutical companies within the VFA, included a total of 224 inspections (74 inspections in Germany, 150 from other European countries. Most frequent findings in and outside Germany were related to “documentation” (40.5% vs. 21.3%, “investigational new drugs” (16.2% vs. 14.7%, “drug safety” (13.5% vs. 8% and “application for a clinical trial authorization” (5.4% vs. 12%. From a German perspective, key findings of this working group were the necessity for a clear differentiation of responsibilities between national and federal as well as international authorities, a harmonization of inspection procedures and topics, and a clarification of whether pre-study/on-study and pre-approval/post-approval GCP inspections of the federal higher authority are included in the “Zentralstelle der Länder für Gesundheitsschutz bei Arzneimitteln und Medizinprodukten” (ZLG requirements. The survey illustrated, that inspections usually are conducted at the investigational site, and that most of the findings are well known and thus could be prevented by communicating and discussing

  4. GCP inspections in Germany and Europe following the implementation of the Directive 2001/20/EC

    Science.gov (United States)

    Göbel, Claus; Baier, Dieter; Ruhfus, Birgit; Hundt, Ferdinand

    2009-01-01

    Background: The implementation of the Clinical Trials Directive 2001/20/EC and the Good Clinical Practice Directive 2005/28/EC fundamentally restructured and harmonized the conduct of clinical trials in Europe. GCP inspections – which affect study sites, laboratories, sponsors and contract research organizations (CRO) alike – make up an important part of these regulations. A common understanding of how these regulations apply in daily life is however not always ensured. Methods: A working group of the Clinical Research/Quality Assurance subcommittee of the German Association of Research-Based Pharmaceutical Companies (VFA) was established to outline the regulatory requirements, the experience gathered with inspections by means of a survey and to set up guidance on how to manage an inspection. Results and conclusions: The survey, conducted with the help of 15 pharmaceutical companies within the VFA, included a total of 224 inspections (74 inspections in Germany, 150 from other European countries). Most frequent findings in and outside Germany were related to “documentation” (40.5% vs. 21.3%), “investigational new drugs” (16.2% vs. 14.7%), “drug safety” (13.5% vs. 8%) and “application for a clinical trial authorization” (5.4% vs. 12%). From a German perspective, key findings of this working group were the necessity for a clear differentiation of responsibilities between national and federal as well as international authorities, a harmonization of inspection procedures and topics, and a clarification of whether pre-study/on-study and pre-approval/post-approval GCP inspections of the federal higher authority are included in the “Zentralstelle der Länder für Gesundheitsschutz bei Arzneimitteln und Medizinprodukten” (ZLG) requirements. The survey illustrated, that inspections usually are conducted at the investigational site, and that most of the findings are well known and thus could be prevented by communicating and discussing audit results

  5. Clinical association between teeth malocclusions, wrong posture and ocular convergence disorders: an epidemiological investigation on primary school children

    Directory of Open Access Journals (Sweden)

    Silvestrini-Biavati Armando

    2013-01-01

    Full Text Available Abstract Background As the various systems in the body are inter-connected to form a single structural unit, a pathological condition in one area can also affect other areas. There are many known correlations between the visual and motor system. The importance of visual function, particularly the paracentral peripheral field of view, in motor coordination, ambulation and the maintenance of balance has been amply demonstrated. In line with current medical principles, which are moving towards a more holistic view of the human body, this study aims to investigate, in an interdisciplinary manner, the incidence of dental malocclusions together with posture and eye convergence disorders. Methods Six hundred and five children attending at the 3rd, 4th and 5th years of seven Genoa primary schools were examined. Each child underwent the following examinations: (i dental/occlusal; (ii orthoptic; and (iii postural. Occlusal data concerned the presence of cross-bite, midline deviation with a mandibular shift, bad habits and deep or open bite. Postural assessment involved frontal and lateral inspection, investigation during trunk flexion and ambulation, and note of any asymmetry in the lower limbs. The recorded orthoptic data included those pertaining to ocular dominance, a cover test, convergence and the Brock string test. Results A prevalence of cases with an unphysiological gait was found in patients with overjet (14.70% or overbite (14.87%, while the percentage of patients with normal occlusion that showed an unphysiological gait was 13.08%. Also, about 93.8%–94.2% of children showed normal legs without dysmetry, with no difference in respect to the type of occlusion. Subjects with an open bite or deep bite showed a slightly different distribution of right or left dominant eyes. Conclusion About 13% of children showed a pathological gait and, among them, vertical anomalies of occlusion (deep bite or open bite were prevalent with respect to the other

  6. Using thermographic cameras to investigate eye temperature and clinical severity in depression

    Science.gov (United States)

    Maller, Jerome J.; George, Shefin Sam; Viswanathan, Rekha Puzhavakkathumadom; Fitzgerald, Paul B.; Junor, Paul

    2016-02-01

    Previous studies suggest that altered corneal temperature may be a feature of schizophrenia, but the association between major depressive disorder (MDD) and corneal temperature has yet to be assessed. The aim of this study is to investigate whether eye temperature is different among MDD patients than among healthy individuals. We used a thermographic camera to measure and compare the temperature profile across the corneas of 16 patients with MDD and 16 age- and sex-matched healthy subjects. We found that the average corneal temperature between the two groups did not differ statistically, although clinical severity correlated positively with right corneal temperature. Corneal temperature may be an indicator of clinical severity in psychiatric disorders, including depression.

  7. Software Formal Inspections Guidebook

    Science.gov (United States)

    1993-01-01

    The Software Formal Inspections Guidebook is designed to support the inspection process of software developed by and for NASA. This document provides information on how to implement a recommended and proven method for conducting formal inspections of NASA software. This Guidebook is a companion document to NASA Standard 2202-93, Software Formal Inspections Standard, approved April 1993, which provides the rules, procedures, and specific requirements for conducting software formal inspections. Application of the Formal Inspections Standard is optional to NASA program or project management. In cases where program or project management decide to use the formal inspections method, this Guidebook provides additional information on how to establish and implement the process. The goal of the formal inspections process as documented in the above-mentioned Standard and this Guidebook is to provide a framework and model for an inspection process that will enable the detection and elimination of defects as early as possible in the software life cycle. An ancillary aspect of the formal inspection process incorporates the collection and analysis of inspection data to effect continual improvement in the inspection process and the quality of the software subjected to the process.

  8. Technical objectives of inspection

    International Nuclear Information System (INIS)

    The various technical objectives of inspection are discussed in a very general manner. The discussion includes how the inspection function is related to the assumed threat, the various degrees of assurance and reliance on criteria, and the hierarchy of assurance which is obtained from the various types or levels of inspection

  9. Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges.

    Science.gov (United States)

    McKenna, Dennis J

    2004-05-01

    Ayahuasca is a hallucinogenic beverage that is prominent in the ethnomedicine and shamanism of indigenous Amazonian tribes. Its unique pharmacology depends on the oral activity of the hallucinogen, N,N-dimethyltryptamine (DMT), which results from inhibition of monoamine oxidase (MAO) by beta-carboline alkaloids. MAO is the enzyme that normally degrades DMT in the liver and gut. Ayahuasca has long been integrated into mestizo folk medicine in the northwest Amazon. In Brazil, it is used as a sacrament by several syncretic churches. Some of these organizations have incorporated in the United States. The recreational and religious use of ayahuasca in the United States, as well as "ayahuasca tourism" in the Amazon, is increasing. The current legal status of ayahuasca or its source plants in the United States is unclear, although DMT is a Schedule I controlled substance. One ayahuasca church has received favorable rulings in 2 federal courts in response to its petition to the Department of Justice for the right to use ayahuasca under the Religious Freedom Restoration Act. A biomedical study of one of the churches, the Uñiao do Vegetal (UDV), indicated that ayahuasca may have therapeutic applications for the treatment of alcoholism, substance abuse, and possibly other disorders. Clinical studies conducted in Spain have demonstrated that ayahuasca can be used safely in normal healthy adults, but have done little to clarify its potential therapeutic uses. Because of ayahuasca's ill-defined legal status and variable botanical and chemical composition, clinical investigations in the United States, ideally under an approved Investigational New Drug (IND) protocol, are complicated by both regulatory and methodological issues. This article provides an overview of ayahuasca and discusses some of the challenges that must be overcome before it can be clinically investigated in the United States. PMID:15163593

  10. Laboratory animals pulmonary clearance study with chromium 51 labelled polystyrene spherical particles: investigations for clinical application

    International Nuclear Information System (INIS)

    Polystyrene spherical particles labelled with chromium 51, retaining a small amount of chromium acetylacetonate, were administered through different ways to laboratory animals, mice, rats, dogs and monkeys, in order to work out a suitable technique for clinical investigations. The following results were obtained: radioactive labelling may be considered as stable because in vivo chromium elution from the particles does not exceed 0.1% daily. No short-term toxicity has been found for any of the ways of administration due to acetylacetonate or the particles themselves. Long-term pulmonary clearance of inhaled polystyrene particles is close to that of metallic oxides, and no detectable nuisance was observed

  11. Hysterosalpingographic picture encountered during the investigation of female infertility clinic has Lemba of Saint Raphael

    International Nuclear Information System (INIS)

    A cross-sectional study was conducted at the St Raphael Lemba Clinic on a sample of 115 patients suspected of infertility during the period from june 1 1997 in 1 march 2003 (6 years). The technique of hysterosalpingography has allowed the identification of female infertility presents images that can diagnose one or more causes utero-tubal. Men also carry a significant responsibility in the genesis of the sterility of the couple: thus, they must also undergo exploration. Hormonal factors also have an important contribution in the investigation of infertility in women and must be taken in addition to hysterosalpingography

  12. pO2 distribution in malignant tumors before and during radiotherapy -clinical investigations

    International Nuclear Information System (INIS)

    Using pO2 histography data about the oxygenation of tumors can be obtained with a high space resolution in patients. Together with few other European groups investigation of pO2 distribution during radiooncological therapy with regard to the problem of reoxygenation were conducted. Not yet enough tumors have been measured to present already a definitive conclusion. Much more data must be collected to get clearness what kind of tumor will become reoxygenated and what tumors will have no change or a decrease in oxygenation during radiotherapy. To continue these investigations appears to be very important for clinical radiooncology. In the future hypoxic sensitizers or cytotoxic drugs against hypoxic tumor cells may be applied in a better defined way. 8 refs., 5 figs., 1 tab

  13. Clinical FDG PET CT in the Investigation of Suspected Inflammatory and Infective Conditions

    DEFF Research Database (Denmark)

    Lorenz, Eleanor; Wig, Surabhi; Prakash, Vineet

    PURPOSE          F18 FDG PET CT is an established molecular imaging technique most commonly used in the diagnosis and staging of oncological conditions. A rapidly growing clinical application of PET CT is in the investigation of inflammatory and infectious diseases. A review of PET CT scans...... scanning after multiple diagnostic investigations failed to determine a diagnosis.                   RESULTS          PET CT was useful in all 59 cases; revealing malignancy in 11 (2 of whom had associated myositis), systemic vasculitis in 9, inflammatory arthropathy in 5, infectious/other inflammatory...... performed in a tertiary referal centre is presented illustrating its applications and clinical value in the evaluation of suspected or known inflammatory conditions.                   METHOD AND MATERIALS          a retrospective case review of 59 patients was carried out. all patients underwent PET CT...

  14. Electron probe microanalysis for clinical investigations: Microdrop and soft tissue analysis

    International Nuclear Information System (INIS)

    The most important advantage offered by electron probe microanalysis (EPA) for clinical investigations is the ability to analyze smaller volumes of tissue than is possible with conventional techniques. The sample can be a biological soft tissue specimen, which involves subcellular localization, or a picoliter fluid droplet. In either case, the analysis can be nondestructive and permit multiple analyses for a number of elements in a given sample. The most highly developed electron microprobe analytical technique is fluid drop analysis, popularly referred to as microdrop analysis. This method provides the investigator with an analytic capability that has an accuracy of measurement often 1% or better on 20 to 30 picoliter fluid droplets. Electron microprobe techniques have been used for studies of animal hard tissue and for studies that involve insoluble inclusions. However, the development of techniques for studies of labile constituents in animal soft tissue has been much slower. It has been necessary not only to develop appropriate methods of tissue preparation, but also to establish sound techniques for tissue collection. Although there are adequate methods for collection of most types of tissue from laboratory animals, many of these methods are not suitable for human subjects. In order to provide the reader with a better understanding of the capabilities and potential for the application of electron microprobe methodology to problems in clinical medicine, the authors discuss some of their experiences with liquid droplet analysis and quantitative electrolyte distribution measurements in animal soft tissue

  15. Investigation of paramedics' compliance with clinical practice guidelines for the management of chest pain.

    LENUS (Irish Health Repository)

    Figgis, Ken

    2012-01-31

    BACKGROUND: Acute coronary syndromes remain a leading cause of preventable early deaths. However, previous studies have indicated that paramedics\\' compliance with chest pain protocols is suboptimal and that many patients do not receive the benefits of appropriate prehospital treatment. AIMS: To evaluate paramedics\\' level of compliance with national clinical practice guidelines and to investigate why, in certain circumstances, they may deviate from the clinical guidelines. SETTING: The Health Service Executive Mid-Western Regional Ambulance Service which serves a mixed urban and rural population across three counties in the west of Ireland. METHOD: A retrospective review of completed ambulance Patient Care Report Forms was conducted for all adult patients with non-traumatic chest pain treated between 1 December 2007 and 31 March 2008. During the same study period, paramedics were asked to complete a prospective questionnaire survey investigating the rationale behind their treatment decisions, their estimation of patient risk and their attitudes towards the clinical practice guidelines and training. RESULTS: 382 completed Patient Care Report Forms were identified for patients with chest pain, of whom 84.8% received ECG monitoring, 75.9% were given oxygen, 44.8% were treated with sublingual glyceryl trinitrate (GTN) and 50.8% were treated with aspirin. Only 20.4% of patients had a prehospital 12-lead ECG recorded. 58 completed questionnaires were returned (response rate 15%); 64% of respondents said they had received insufficient training to identify ECG abnormalities. CONCLUSIONS: Prehospital treatment with oxygen, aspirin, sublingual GTN and ECG monitoring remains underused by paramedics, even though only a small number of patients had documented contraindications to their use. The small number of patients who received a prehospital 12-lead ECG is a cause of particular concern and suggests that incomplete patient assessment may contribute to undertreatment

  16. 对比不同心肌损伤生化标记物检验的临床意义%Compare the Clinical Significance of the Biochemical Markers of Myocardial Damage Inspection

    Institute of Scientific and Technical Information of China (English)

    王博; 马昉

    2015-01-01

    目的:对比不同心肌损伤生化标记物检验的临床意义。方法随机选自2011年10月~2012年10月我院收治的80例心肌损伤患者,采用 AU640全自动型的生化仪对其心肌钙蛋白、肌红蛋白 I、血同型半胱氨酸、脑利钠肽前体、肌酸激酶同工酶水平进行相应的检测,对检验过程中不同标记物的应用价值及特点进行分析。结果80例心肌损伤患者经过相应的检测之后,灵敏度最高的是脑利钠肽前体,最低的是血同型半胱氨酸。结论在五种不同的心肌损伤生化标记物的检验过程中,各种标记物均可发挥明显的指导意义,对不同的标记物进行联合检测可以使诊治效果得到提升。%Objective To compare the clinical significance of the biochemical markers of myocardial damage inspection. Methods Randomly selected from October 2011 to October 2012,our hospital 80 cases of patients with myocardial injury,using type AU640 automatic biochemical instrument on the myocardial calcium,protein,myoglobin I,blood homocysteine,brain natriuretic peptide precursor,creatine kinase isoenzyme level corresponding detection,in the process of inspection application value and characteristics of different markers were analyzed. Results 80 cases of patients with myocardial injury after the corresponding detection,sensitivity is the highest brain natriuretic peptide precursor,blood homocysteine are the lowest. Conclusion In five different biochemical markers of myocardial injury during the process of inspection,al kinds of markers can play a significant guiding significance,for different markers for joint detection can make make a diagnosis and give treatment effect is improved.

  17. Preparing for an FDA preapproval inspection.

    Science.gov (United States)

    Blackmer, R A

    1994-12-01

    During the past several years, the U.S. Food and Drug Administration (FDA) has increased its compliance and enforcement activities in relation to the approval of new pharmaceutical products. FDA has published Compliance Program Guidance Manual 7346.832, "preapproval inspections/investigations," which describes the manner in which FDA will manage this program, as well as describing expectations concerning laboratory and production controls for the development and manufacturing of a new product. This program, and the dialogue that it has stimulated between the agency and the pharmaceutical industry, has helped define contemporary criteria for assessing the validity of scientific and technical data supporting marketing applications. The program focuses on a comparison of the proposed commercial manufacturing process vis-a-vis the methods and controls used to produce supplies utilized in pivotal clinical and bioequivalence studies. This article presents an industry perspective regarding preparation for an FDA preapproval inspection (PAI) for two categories of products: those which were under development before the expectations of the PAI program were fully elucidated and those which are entering the development pipeline today. PMID:7613749

  18. Clinical Relevance of the Advanced Microbiologic and Biochemical Investigations in Periodontal Diagnosis: A Critical Analysis

    Directory of Open Access Journals (Sweden)

    Vishakha Grover

    2014-01-01

    Full Text Available New approaches to periodontal diagnosis, including advanced microbiologic, biochemical, and genetic tests, have been shown to provide the clinician with the information not available by traditional means. The purpose of a diagnostic test is to confirm, exclude, classify, or monitor disease to guide treatment. Their clinical value depends on whether the information they provide leads to improved patient outcomes. This can be assessed by randomized trials, which compare patient outcomes from the new diagnostic test versus the old test strategy. Being nonmandatory for marketing approval, such trials are not always feasible because of large sample sizes requirements. So, many diagnostic tests enter the practice without being critically analysed for any additional benefits. Effective diagnosis is just as essential as the selection of effective treatments for the success of periodontal therapy. So, the current paper aims to focus on the practical utility of this rapidly emerging plethora of periodontal diagnostic tools, emphasizing the critical issues surrounding the clinical application of microbiologic and biochemical investigations, employed for periodontal diagnosis.

  19. An Investigation of Factors Influencing Nurses' Clinical Decision-Making Skills.

    Science.gov (United States)

    Wu, Min; Yang, Jinqiu; Liu, Lingying; Ye, Benlan

    2016-08-01

    This study aims to investigate the influencing factors on nurses' clinical decision-making (CDM) skills. A cross-sectional nonexperimental research design was conducted in the medical, surgical, and emergency departments of two university hospitals, between May and June 2014. We used a quantile regression method to identify the influencing factors across different quantiles of the CDM skills distribution and compared the results with the corresponding ordinary least squares (OLS) estimates. Our findings revealed that nurses were best at the skills of managing oneself. Educational level, experience, and the total structural empowerment had significant positive impacts on nurses' CDM skills, while the nurse-patient relationship, patient care and interaction, formal empowerment, and information empowerment were negatively correlated with nurses' CDM skills. These variables explained no more than 30% of the variance in nurses' CDM skills and mainly explained the lower quantiles of nurses' CDM skills distribution. PMID:26906246

  20. Assessing the detection, reporting and investigation of adverse events in clinical trial protocols implemented in Cameroon: a documentary review of clinical trial protocols

    OpenAIRE

    Ebile, Akoh Walter; Ateudjieu, Jerome; Yakum, Martin Ndinakie; Djuidje, Marceline Ngounoue; Watcho, Pierre

    2015-01-01

    Background International guidelines recommend ethical and scientific quality standards for managing and reporting adverse events occurring during clinical trials to competent research ethics committees and regulatory authorities. The purpose of this study was to determine whether clinical trial protocols in Cameroon are developed in line with national requirements and international guidelines as far as detecting, reporting and investigating of adverse events is concerned. Methods It was a doc...

  1. Typical investigational medicinal products follow relatively uniform regulations in 10 European Clinical Research Infrastructures Network (ECRIN) countries

    DEFF Research Database (Denmark)

    Gluud, Christian; Kubiak, Christine; Whitfield, Kate;

    2012-01-01

    In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medicinal products in Europe.......In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medicinal products in Europe....

  2. Investigation of a portable performance measurement system for neurologic screening in clinics.

    Science.gov (United States)

    Kondraske, George V; Mulukutla, Rahul; Stewart, R Malcolm

    2006-01-01

    Motivated by the need for clinical screening for early detection of neurologic disease, a prototype portable instrument dubbed the human performance multimeter (HPMM) was developed. The HPMM is based on a set of lab-based performance capacity tests developed and evaluated over the last two decades. We attempted to integrate selected functionality of a set of modular lab-based instruments into a single, small package. In the present study, a 4th generation prototype was developed and evaluated for usability, measurement repeatability, and preliminary measurement validity. Five performance capacity tests (upper extremity coordination, isometric grip strength, simple response speed, rapid alternating movement, and steadiness/tremor) were administered to twenty healthy adult volunteers. Short-term reliability was investigated using a test-retest protocol. Most measures were found to possess good test-retest reliability (r>0.75). Preliminary validity was investigated by comparing results to those obtained with non-portable devices that served as models for the HPMM. Results were in good agreement with those instruments. It is concluded that measures of good fidelity can be obtained with this type of instrument. PMID:17946212

  3. Investigations of portable cadmium telluride (CdTe(Cl)) detectors for clinical studies with radioactive indicators

    International Nuclear Information System (INIS)

    The combination of small, portable γ-radiation-sensitive Cadmium Telluride (CdTE(Cl)) crystal detectors and portable solid state data storage memories makes it feasible to extend the measuring period in a number of clinical investigations based on the use of various radioisotopes and external detection. Blood sampling can be avoided in some cases. Continuous ambulatory monitoring of relevant physiological parameters is practicable, e.g. kidney function (GFR), left ventricular ejection fraction, subcutaneous blood flow, muscle blood flow and insulin absorption in diabetic patients. In the present methodological study the applicability of the 133-Xe washout technique to subcutaneous (s.c.) adipose tissue blood flow (SBF) has been investigated and adapted to the use of CdTe(Cl) detectors attached to the skin surface for the measurement of local 133-Xe-disappearance rate constants (k). Physical characterization of CdTe(Cl) detectors as γ-sensitive devices has been performed, and adequate counting sensitivities were found without detector energy-resolution properties. The CdTe(Cl) detectors are therefore suitable for single indicator studies. The measuring geometry of CdTe(Cl) detectors was studied and compared with that of stationary Sodium Iodide (NaI(Tl)) detectors in both phantom and in vivo investigations. The spatial properties of CdTe(Cl) detectors could to some extent be adjusted by pulse height discrimination and lead collimation. When long-term measurements were complicated by for instance physical activity of the patients, the small CdTe(Cl) detectors in general showed equal or better performance than the heavy and voluminous NaI(Tl) detectors. The free movement of the ambulatory patient and the avoidance of cable connections to stationary data-collecting systems gave improved possibilities for measurements of the relevant parameters. From this point of view, portable CdTe(Cl) detectors must be considered an important advance for radioactivity studies in

  4. Investigation of the clinical potential of scattering foil free electron beams

    International Nuclear Information System (INIS)

    Electron beam therapy has been an important radiation therapy modality for many decades. Studies have been conducted recently for more efficient and advanced delivery of electron beam radiation therapy. X-ray contamination is a common problem that exists with all of the advanced electron beam therapy techniques such as Bolus Electron conformal therapy, segmented electron conformal therapy, and modulated electron arc therapy. X-ray contamination could add some limitations to the advancement and clinical utility of those electron modalities. It was previously shown in the literature that the scattering foil is one of the major accelerator parts contributing to the generation of bremsstrahlung photons. Thus, in this work we investigate the dosimetric characteristics of scattering foil free (SFF) electron beams and the feasibility of using those beams for breast cancer boosts. The SFF electron beams were modeled and simulated using the Monte Carlo method. CT scans of six previously treated breast patients were used for the treatment plan generation utilizing our in-house Monte Carlo-based treatment planning system. Electron boost plans with conventional beams and the SFF beams were generated, respectively, for all patients. A significant reduction of the photon component was observed with the removal of the primary scattering foil for beam energies higher than 12 MeV. Flatness was greatly affected but the difference in flatness between conventional and SFF beams was much reduced for small cone sizes, which were often used clinically for breast boosts. It was found that the SFF electron beams could deliver high-quality dose distributions as conventional electron beams for boost treatments of the breast with an added advantage of a further reduced dose to the lung and the heart. (paper)

  5. Preclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned?

    Science.gov (United States)

    Scheuing, Lisa; Chiu, Chi-Tso; Liao, Hsiao-Mei; Linares, Gabriel R; Chuang, De-Maw

    2014-01-01

    Huntington's disease (HD) is a lethal, autosomal dominant neurodegenerative disorder caused by CAG repeat expansions at exon 1 of the huntingtin (Htt) gene, which encodes for a mutant huntingtin protein (mHtt). Prominent symptoms of HD include motor dysfunction, characterized by chorea; psychiatric disturbances such as mood and personality changes; and cognitive decline that may lead to dementia. Pathologically multiple complex processes and pathways are involved in the development of HD, including selective loss of neurons in the striatum and cortex, dysregulation of cellular autophagy, mitochondrial dysfunction, decreased neurotrophic and growth factor levels, and aberrant regulation of gene expression and epigenetic patterns. No cure for HD presently exists, nor are there drugs that can halt the progression of this devastating disease. Therefore, the need to discover neuroprotective modalities to combat HD is critical. In basic and preclinical studies using cellular and animal HD models, the mood stabilizers lithium and valproic acid (VPA) have shown multiple beneficial effects, including behavioral and motor improvement, enhanced neuroprotection, and lifespan extension. Recent studies in transgenic HD mice support the notion that combined lithium/VPA treatment is more effective than treatment with either drug alone. In humans, several clinical studies of HD patients found that lithium treatment improved mood, and that VPA treatment both stabilized mood and moderately reduced chorea. In contrast, other studies observed that the hallmark features of HD were unaffected by treatment with either lithium or VPA. The current review discusses preclinical and clinical investigations of the beneficial effects of lithium and VPA on HD pathophysiology. PMID:25285035

  6. An investigation of the roles and functions of nurse preceptors in the clinical areas

    OpenAIRE

    S.C. Cele; H.A. Gumede; B. A. Kubheka

    2002-01-01

    This article explores the confusion that exists in the clinical areas concerning proper accompaniment of student nurses. There is a feeling that professional nurses in clinical areas are not always actively involved in clinical teaching. The clinical instructors and nurse educators are unable to accompany student nurses properly because of staff shortages. Some hospitals have identified one professional nurse per unit to work as a nurse preceptor for accompaniment of student nurses. This has ...

  7. Contineous inspection during fabrication

    International Nuclear Information System (INIS)

    The continuous inspection process is a method used in a Manufacturing plant in order to obtain a fast feed-back between inspection results and manufacturing process. It often requires a specific approach in design and a wide cooperation between Engineering and Manufacturing people. This method leads to additional advantages such as high motivation, and better quality knowledge. (orig.)

  8. [Non-commercial clinical trials--who will be the legal sponsor? Sponsorship of investigator-initiated clinical trials according to the German Drug Law].

    Science.gov (United States)

    Benninger-Döring, G; Boos, J

    2006-07-01

    Non-commercial clinical trials may be of great benefit to the patients concerned. The 12th amendment to the German Drug Law (AMG) changed legal liability of the initiators of investigator-initiated clinical trials with extensive consequences for traditional project leaders. The central point under discussion is the sponsor's responsibility according to the AMG. Presently leading management divisions of university hospitals and universities are developing proceedings to assume sponsor responsibility by institutions (institutional sponsorship), which should enable investigator-initiated clinical trials to be conducted according to legal requirements in the future. Detailed problems and special questions can only be resolved in a single-minded fashion, and if necessary political processes should be catalyzed. PMID:16763801

  9. Randomized Clinical Investigation of Titanium Implants with and without Platform Switching: Six Months’ Radiographic and Clinical Outcome

    Directory of Open Access Journals (Sweden)

    Roberto Rossi

    2015-04-01

    Full Text Available The aim of this study was to obtain a randomized, clinical and radiological comparison of implants with and without platform switching (PFS. The two compared titanium implant types differed only in the microgap position: test (PFS or control (StE, no PFS. All implants were inserted in posterior regions and followed up for six months after abutment connection (AC. Twenty one patients with 21 PFS and 18 StE implants completed the six-month evaluation. No implant failed. One complication (exposed cap screw was reported at AC. No statistically significant difference was observed between the marginal bone level of PFS and StE implants. Their bone level stabilized approximately 1 mm below the microgap. Based on the outcome of this short-term study with a limited number of patients, it seems unlikely that the optimal clinical and radiological outcome obtained with the tested standard implant (no PFS can be improved by introducing an inward microgap shift (PFS.

  10. Non-inflammatory destructive periodontal disease: a clinical, microbiological, immunological and genetic investigation

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Repeke

    2012-02-01

    Full Text Available Periodontitis comprises a group of multifactorial diseases in which periodontopathogens accumulate in dental plaque and trigger host chronic inflammatory and immune responses against periodontal structures, which are determinant to the disease outcome. Although unusual cases of non-inflammatory destructive periodontal disease (NIDPD are described, their pathogenesis remains unknown. A unique NIDPD case was investigated by clinical, microbiological, immunological and genetic tools. The patient, a non-smoking dental surgeon with excessive oral hygiene practice, presented a generalized bone resorption and tooth mobility, but not gingival inflammation or occlusion problems. No hematological, immunological or endocrine alterations were found. No periodontopathogens (A. actinomycetemcomitans, P. gingivalis, F. nucleatum and T. denticola or viruses (HCMV, EBV-1 and HSV-1 were detected, along with levels of IL-1β and TNF-a in GCF compatible with healthy tissues. Conversely ALP, ACP and RANKL GCF levels were similar to diseased periodontal sites. Genetic investigation demonstrated that the patient carried some SNPs, as well HLA-DR4 (*0404 and HLA-B27 alleles, considered risk factors for bone loss. Then, a less vigorous and diminished frequency of toothbrushing was recommended to the patient, resulting in the arrest of alveolar bone loss, associated with the return of ALP, ACP and RANKL in GCF to normality levels. In conclusion, the unusual case presented here is compatible with the previous description of NIDPD, and the results that a possible combination of excessive force and frequency of mechanical stimulation with a potentially bone loss prone genotype could result in the alveolar bone loss seen in NIDPD.

  11. Clinical and genetic investigation of families with type II Waardenburg syndrome.

    Science.gov (United States)

    Chen, Yong; Yang, Fuwei; Zheng, Hexin; Zhou, Jianda; Zhu, Ganghua; Hu, Peng; Wu, Weijing

    2016-03-01

    The present study aimed to investigate the molecular pathology of Waardenburg syndrome type II in three families, in order to provide genetic diagnosis and hereditary counseling for family members. Relevant clinical examinations were conducted on the probands of the three pedigrees. Peripheral blood samples of the probands and related family members were collected and genomic DNA was extracted. The coding sequences of paired box 3 (PAX3), microphthalmia‑associated transcription factor (MITF), sex‑determining region Y‑box 10 (SOX10) and snail family zinc finger 2 (SNAI2) were analyzed by polymerase chain reaction and DNA sequencing. The heterozygous mutation, c.649_651delAGA in exon 7 of the MITF gene was detected in the proband and all patients of pedigree 1; however, no pathological mutation of the relevant genes (MITF, SNAI2, SOX10 or PAX3) was detected in pedigrees 2 and 3. The heterozygous mutation c.649_651delAGA in exon 7 of the MITF gene is therefore considered the disease‑causing mutation in pedigree 1. However, there are novel disease‑causing genes in Waardenburg syndrome type II, which require further research. PMID:26781036

  12. Clinical investigation study on occupational exposure of operators during cardiovascular intervention

    International Nuclear Information System (INIS)

    Objective: To investigate the personal effective dose of the operator in cardiovascular intervention. Methods: Lithium fluoride (LiF) thermoluminescent dosimeters (TLD) were used to carry out personal dose monitoring for the operator. Effective doses of the operator were evaluated in 28 clinical operations. Results: The average fluoroscopy time for 24 Coronary angiography (CA), percutaneous transluminal coronary angioplasty (PTCA) and percutaneous intracoronary arterial stenting (PICAS) procedures was 19.2±6.3 min, and the average effective dose of the operator per procedure was 4.1±0.9 μSv (under protection) and 52.2±15.5 μSv (without protection). However, for 4 PT procedures, average fluoroscopy time was 14.1±4.6 min, and the average effective dose of the operator per operation was 5.5±1.4 μSv (under protection) and 220±42 μSv (without protection). Conclusions: Reducing fluoroscopy time, femoral artery access to the patients are recommended during interventional procedures. In order to decrease the radiation risk to the lowest level, more advanced equipment should be applied and radiation protection should be fully managed. (authors)

  13. Polythelia: simple atavistic remnant or a suspicious clinical sign for investigation?

    Science.gov (United States)

    Galli-Tsinopoulou, Assimina; Stergidou, Dorothea

    2014-03-01

    Supernumerary nipples (or polythelia) usually appear along the embryonic milk lines or in other sites including the back, thigh, vulva, neck etc. The frequency of polythelia ranges from 0.2% to 5.6%. Despite the plethora of published cases concerning its association with other congenital malformations or syndromes with different patterns of inheritance, polythelia still remains a controversial and theoretical issue. Although most reports describe a link between supernumerary nipples and kidney/urinary tract anomalies, a potential relationship with other congenital anomalies or malignancies has also been speculated. Additionally, polythelia has been associated with genodermatoses, thus being related with an increased malignant potential, as well as with an increased risk for solid tumors such as renal adenocarcinoma, testicular cancer, prostate cancer, and urinary bladder carcinoma. The fact that the Scaramanga (ska) mutant mice presented with ectopic breast tissue imply that misregulation of the neuregulin-3 signaling pathway may be critical in the occurrence of polythelia. This is an attempt to review existing literature in order to (a) draw reliable conclusions whether polythelia is a manifestation of simple atavism or may be associated with concomitant severe conditions needing further investigation and/or management, (b) elucidate its aetiology and (c) establish appropriate clinical and laboratory approach. PMID:24716395

  14. Ischaemic memory imaging using metabolic radiopharmaceuticals: overview of clinical settings and ongoing investigations

    Energy Technology Data Exchange (ETDEWEB)

    Yoshinaga, Keiichiro [Hokkaido University Graduate School of Medicine, Department of Molecular Imaging, Sapporo (Japan); Naya, Masanao [Hokkaido University Graduate School of Medicine, Department of Cardiology, Sapporo (Japan); Shiga, Tohru; Suzuki, Eriko; Tamaki, Nagara [Hokkaido University Graduate School of Medicine, Department of Nuclear Medicine, Sapporo (Japan)

    2014-02-15

    ''Ischaemic memory'' is defined as a prolonged functional and/or biochemical alteration remaining after a particular episode of severe myocardial ischaemia. The biochemical alteration has been reported as metabolic stunning. Metabolic imaging has been used to detect the footprint left by previous ischaemic episodes evident due to delayed recovery of myocardial metabolism (persistent dominant glucose utilization with suppression of fatty acid oxidation). β-Methyl-p-[{sup 123}I]iodophenylpentadecanoic acid (BMIPP) is a single-photon emission computed tomography (SPECT) radiotracer widely used for metabolic imaging in clinical settings in Japan. In patients with suspected coronary artery disease but no previous myocardial infarction, BMIPP has shown acceptable diagnostic accuracy. In particular, BMIPP plays an important role in the identification of prior ischaemic insult in patients arriving at emergency departments with acute chest pain syndrome. Recent data also show the usefulness of {sup 123}I-BMIPP SPECT for predicting cardiovascular events in patients undergoing haemodialysis. Similarly, SPECT or PET imaging with {sup 18}F-FDG injected during peak exercise or after exercise under fasting conditions shows an increase in FDG uptake in postischaemic areas. This article will overview the roles of ischaemic memory imaging both under established indications and in ongoing investigations. (orig.)

  15. Variability of intraductal papillomas of the mammary gland: Clinical, roentgenologic and morphologic investigations

    International Nuclear Information System (INIS)

    The radiodiagnostical method of choice is the galactographic technique. However, a specific X-ray image of the papilloma does not exist. The galactographic technique has to be adapted to the surgical and histologic one. Only by combining these three techniques good results can be achieved. It is not possible to draw conclusions from the colour of the pathologic discharge about the type and character of the pathologic process. Contrary to the findings documented in the literature, we were able to diagnose with our technique not only small tumours, but also tumours situated in the periphery of the lactiferous duct. Because of our investigations it is no longer possible to maintain and keep the strict division of the proliferative changes occurring at the lactiferous duct walls. In this study, the most significant morphologic results are described in detail. In all patients with pathologic discharge of the mammary gland, the so-called papillo-carcinoma was found only in one case. As clinical consequence it has therefore to be demanded that in all women with the symptom of pathologic mamillary discharge first of all the origin of this discharge has to be localised by means of galactography. Only the individual morphologic picture of a proliferative change of the lactiferous duct provides some prognostic value. The prerequisites for such an individual assessment are differentiated roentgenologic, surgical and histological techniques. (orig./MG)

  16. Investigating the Clinical Usefulness of the Social Responsiveness Scale (SRS) in a Tertiary Level, Autism Spectrum Disorder Specific Assessment Clinic

    Science.gov (United States)

    Aldridge, Fiona J.; Gibbs, Vicki M.; Schmidhofer, Katherine; Williams, Megan

    2012-01-01

    The Social Responsiveness Scale (SRS; Constantino and Gruber in Social Responsiveness Scale (SRS). Western Psychological Services, Los Angeles, 2005) is a commonly used screening tool for identifying children with possible autism spectrum disorder (ASD). This study investigated the relationship between SRS scores and eventual diagnostic outcome…

  17. Report on summary results of the inspection of issues regarding the scope of the accident investigation of the TRISTAN Fire at the Brookhaven National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    The subject final report is provided to inform you of our findings and recommendations concerning our review of issues regarding the scope of the accident investigation of a March 31, 1994, fire at the Terrific Reactor Isotope Separator To Analyze Nuclides (TRISTAN) experiment at the Department of Energy (DOE) Brookhaven National Laboratory (BNL), Upton, New York. The Chicago Operations Office (CH) Manager appointed a Type B Accident Investigation Board (Board) to investigate the fire. In a June 16, 1994, letter to the Inspector General, DOE, the CH Manager requested the Inspector General to look into an allegation by a former Board member that senior Chicago management consciously violated the requirements of DOE Order 5484.1, {open_quotes}Environmental Protection, Safety, And Health Protection Information Reporting Requirements,{close_quotes} in attempting to control the investigation. The former Board member alleged that there was not a clear verbal agreement among the Board members regarding the focus of the scope of the investigation. He said that the Board Chairman wanted to focus on the physical causes of the fire, while he (the former Board member) believed that the Board should focus on the apparent management deficiencies that allowed TRISTAN to operate without a proper safety analysis and in violation of DOE orders for so many years.

  18. Investigation of Data Representation Issues in Computerizing Clinical Practice Guidelines in China

    OpenAIRE

    Liu, Danhong; Ye, Qing; Yang, Zhe; Yang, Peng; Xu, Yongyong; Su, Jingkuan

    2014-01-01

    Objectives From the point of view of clinical data representation, this study attempted to identify obstacles in translating clinical narrative guidelines into computer interpretable format and integrating the guidelines with data in Electronic Health Records in China. Methods Based on SAGE and K4CARE formulism, a Chinese clinical practice guideline for hypertension was modeled in Protégé by building an ontology that had three components: flowchart, node, and vMR. Meanwhile, data items impera...

  19. Model for investigating the benefits of clinical supervision in psychiatric nursing: a survey study

    DEFF Research Database (Denmark)

    Gonge, Henrik; Buus, Niels

    2011-01-01

    effectiveness of clinical supervision, as measured by the Manchester Clinical Supervision Scale (MCSS). Furthermore, MCSS scores were associated with benefits, such as increased job satisfaction, vitality, rational coping and less stress, emotional exhaustion, and depersonalization. Multivariate analyses......The objective of this study was to test a model for analysing the possible benefits of clinical supervision. The model suggested a pathway from participation to effectiveness to benefits of clinical supervision, and included possible influences of individual and workplace factors. The study sample...... indicated that certain individual and workplace factors were related to subscales of the MCSS, as well as some of the benefits. The study supported the suggested model, but methodological limitations apply....

  20. A clinical investigation of the relationship between the quality of conventional complete dentures and the patients’ quality of life

    OpenAIRE

    Sara A. Alfadda; Hayam A. Al-Fallaj; Al-Banyan, Hajar A.; Ruba M. Al-Kadhi

    2015-01-01

    Objective: The purpose of this study was to determine whether there is a correlation between the clinical quality of conventional complete dentures and patient quality of life. Materials and methods: This study included a random sample of 32 completely edentulous patients (15 males and 17 females) who were treated with conventional complete dentures. Using a validated questionnaire, three investigators evaluated the dentures independently on the basis of seven clinical parameters: esthetic...

  1. Investigations of efficacy of intramammary applied antimicrobials and glucocorticosteroides in the treatment of subclinical and clinical mastitis in cows

    OpenAIRE

    Vakanjac Slobodanka; Pavlović Vojislav; Magaš Vladimir; Pavlović Miloš; Đurić Miloje; Maletić Milan; Nedić Svetlana; Sočo Ivan

    2013-01-01

    Inflammation of the mammary gland, mastitis in cows, presents one of the most acute problems in intensive dairy production, inflicting huge economic losses. In the course of one year, 80 samples were taken at investigated farms from udder quarters of cows with clinical mastitis and 160 samples from udder quarters of cows with subclinical mastitis. The efficacy of three preparations, A, B, and C, was examined in the treatment of clinical and subclinical mast...

  2. Magnetic rubber inspection (MRI)

    International Nuclear Information System (INIS)

    Magnetic Rubber Inspection (MRI) was developed to inspect for small cracks and flaws encountered in high performance aircraft. A formula of very fine magnetic particles immersed in a room temperature curing rubber is catalysed and poured into dams (retainers) on the surface of the part to be inspected. Inducing a magnetic field then causes the particles to be drawn to discontinuities in the component under test. These indicating particles are held to the discontinuity by magnetic attraction, as the rubber cures. The solid rubber cast (Replica) is then removed and examined under a microscope for indicating lines of particle concentrations. 3 refs., 6 figs

  3. Clinical impact of diagnostic SPET investigations with a dopamine re-uptake ligand

    DEFF Research Database (Denmark)

    Løkkegaard, Annemette; Werdelin, Lene M; Friberg, Lars

    2002-01-01

    The diagnosis of Parkinson's disease is based on clinical features with pathological verification. However, autopsy has been found to confirm a specialist diagnosis in only about 75% of cases. Especially early in the course of the disease, the clinical diagnosis can be difficult. Imaging of presy...

  4. Intradiscal electrothermal treatment for discogenic back pain: experimental investigation and preliminary clinical application

    International Nuclear Information System (INIS)

    Objective: To assess the effectiveness and the safety of IDET for chronic discogenic low back pain. Methods: Standard intradiscal electrothermal treatment were performed in two adjacent disc levels (L3-4, L4-5) of two domestic pigs. MRI were available at pretreatment, posttreatment of 1,2 weeks, and then the two animals were killed respectively at 1,2 weeks after the procedure. The specimens were then undergone thin sectioned and subjected to humatoxylin and eosin staining for histological investigation. 23 patients (totally 29 discs, including L2-3 to L5-S1) with chronic symptoms underwent IDET for clinical study. VAS (Visual Analog Scale) pain scores were collected before the treatment, 1 week and 3 months after the procedure. One way ANOVA was used for statistical analysis. Results: 4 discs of standard IDET models have been set up in two pigs showing normal MRI T2W1 signal of nucleus pulposus immediately after the procedure, but the high signal extent of the central part of the nucleo pulposus shrinked with conspicuous peripheral low signal changes during the following 1-2 W. Degeneration and shrinkage of nucleo-pulposus with lecolized fibrous ring thickening were found pathologically but without damage to nurve roots and epidural sac. 29 discs in 23 patients were performed successfully, without complication. The follow-up evaluation of 1 week and 3 months after the treatment showing significant differences with those before the treatment on was scores 65.3% and 78.9% respectively (P<0.0001). Conclusions: IDET is safe and effective for chronic discogenic low back pain. (authors)

  5. Simultaneous Bilateral Carotid Stenting for Symptomatic Bilateral High-Grade Carotid Stenosis: A Retrospective Clinical Investigation

    Science.gov (United States)

    Ye, Ziming; Liu, Ying; Deng, Xiao; Chen, Xiangren; Lin, Cuiting; Tang, Yanyan; Su, Ying; Fang, Lanji; Wu, Yuan; Qin, Chao

    2016-01-01

    Background This retrospective clinical investigation aimed to evaluate the short-term effectiveness and safety of SBCAS for symptomatic bilateral high-grade CS. Material/Methods From 2009 to 2014, 145 patients were recruited. Among them, 70 underwent SBCAS, and other 75 patients underwent SAMM and served as controls. The immediate postprocedural complications and postprocedural neurological evaluation, as well as restenosis at 6-month and 1-year follow-ups in the SBCAS group are reported. Additionally, baseline risk factors for ischemic stroke, adverse effects of drugs, and outcomes at 30-day, 6-month, and 1-year follow-ups were compared between the 2 groups. Results Our data did not reveal significant differences between the 2 groups in baseline risk factors for ischemic stroke. In the SBCAS group, both HPS (5.7%) and HD (40%) occurred, but they were not very severe, and no patients had postprocedural neurological deficit. Moreover, restenosis only occurred in 3 patients at 3 stent placement sites (4.3%) at 1-year follow-up. Adverse effects of drugs did not occur in SBCAS group, but adverse effects of Bayer aspirin and Lipitor occurred in 4 patients (5.4%) and 18 patients (24.3%), respectively, at 6-month follow-up in the control group. Furthermore, there were significant differences in outcomes between the 2 groups at 30-day, 6-month, and 1-year follow-ups, in that NIHSS, CS ratio, and incidence of endpoint events, as well as 1-year cumulative probability of endpoint events, were all lower in the SBCAS group than in the control group (p<0.05). Conclusions Compared to SAMM, we found that SBCAS was more effective and safer for symptomatic bilateral high-grade CS. PMID:27542158

  6. [Is the structure of surgical clinics in Germany changing? A current investigation into the structure of surgical clinics in the Federal Republic of Germany].

    Science.gov (United States)

    Lob, G; Lob, T; Bauer, H; Niethard, F; Polonius, J; Siebert, H

    2009-04-01

    Medical developments have led to extensive specialization in the field of surgery. This has already been reflected for many years in altered structure and organization forms of surgical clinics. Indispensable quality standards, statutory general conditions, increasing competition in service providers and health insurance with transparency of the service procedure all intensify this trend. The aim of this investigation was, therefore, to determine how far this differentiation of service supply in the field of surgery is also reflected in the area and in surgical departments and clinics of basic and routine supply. To achieve this, all available published information on the structure and organization of surgical clinics in the Federal Republic of Germany was classified according to current departmentalization into "undivided" or general/visceral surgery facilities compared to orthopedic/trauma surgery departments. PMID:19290506

  7. Ten years after the first inspection of a candidate European centre, an EBMT registry analysis suggests that clinical outcome is improved when hematopoietic SCT is performed in a JACIE accredited program.

    Science.gov (United States)

    Chabannon, C; Pamphilon, D; Vermylen, C; Gratwohl, A; Niederwieser, D; McGrath, E; Lamers, C; Lanza, F; Slaper-Cortenbach, I; Madrigal, A; Apperley, J

    2012-01-01

    In 2010, JACIE, the Joint Accreditation Committee of ISCT (International Society for Cell Therapy) Europe and EBMT (European group for Blood and Marrow Transplantation) celebrated the tenth anniversary of the first inspection of a European hematopoietic SCT program. JACIE standards establish the criteria for a comprehensive quality management program that covers all three major domains of activity that are necessary for the delivery of HSCT: clinical, collection and processing, as well as their interactions with ancillary and supportive activities. Although more than 200 European programs have applied for JACIE accreditation, and more than 100 have been granted accreditation, a recent retrospective analysis of the large-size EBMT registry of autologous and allogenic hematopoietic HSCT demonstrates that one of the factors affecting the overall survival of recipients of allogenic transplantation is the status of the transplant program regarding JACIE accreditation. This provides one of the first demonstrations that introduction of a quality management system contributes to the overall survival of patients treated with a highly specific medical procedure, and represents a milestone in the implementation of JACIE. PMID:21383685

  8. Guidelines for software inspections

    Science.gov (United States)

    1983-01-01

    Quality control inspections are software problem finding procedures which provide defect removal as well as improvements in software functionality, maintenance, quality, and development and testing methodology is discussed. The many side benefits include education, documentation, training, and scheduling.

  9. Information-Driven Inspections

    International Nuclear Information System (INIS)

    New uranium enrichment capacity is being built worldwide in response to perceived shortfalls in future supply. To meet increasing safeguards responsibilities with limited resources, the nonproliferation community is exploring next-generation concepts to increase the effectiveness and efficiency of safeguards, such as advanced technologies to enable unattended monitoring of nuclear material. These include attribute measurement technologies, data authentication tools, and transmission and security methods. However, there are several conceptual issues with how such data would be used to improve the ability of a safeguards inspectorate such as the International Atomic Energy Agency (IAEA) to reach better safeguards conclusions regarding the activities of a State. The IAEA is pursuing the implementation of information-driven safeguards, whereby all available sources of information are used to make the application of safeguards more effective and efficient. Data from continuous, unattended monitoring systems can be used to optimize on-site inspection scheduling and activities at declared facilities, resulting in fewer, better inspections. Such information-driven inspections are the logical evolution of inspection planning - making use of all available information to enhance scheduled and randomized inspections. Data collection and analysis approaches for unattended monitoring systems can be designed to protect sensitive information while enabling information-driven inspections. A number of such inspections within a predetermined range could reduce inspection frequency while providing an equal or greater level of deterrence against illicit activity, all while meeting operator and technology holder requirements and reducing inspector and operator burden. Three options for using unattended monitoring data to determine an information-driven inspection schedule are to (1) send all unattended monitoring data off-site, which will require advances in data analysis techniques to

  10. Information-Driven Inspections

    Energy Technology Data Exchange (ETDEWEB)

    Laughter, Mark D [ORNL; Whitaker, J Michael [ORNL; Lockwood, Dunbar [U.S. Department of Energy, NNSA

    2010-01-01

    New uranium enrichment capacity is being built worldwide in response to perceived shortfalls in future supply. To meet increasing safeguards responsibilities with limited resources, the nonproliferation community is exploring next-generation concepts to increase the effectiveness and efficiency of safeguards, such as advanced technologies to enable unattended monitoring of nuclear material. These include attribute measurement technologies, data authentication tools, and transmission and security methods. However, there are several conceptual issues with how such data would be used to improve the ability of a safeguards inspectorate such as the International Atomic Energy Agency (IAEA) to reach better safeguards conclusions regarding the activities of a State. The IAEA is pursuing the implementation of information-driven safeguards, whereby all available sources of information are used to make the application of safeguards more effective and efficient. Data from continuous, unattended monitoring systems can be used to optimize on-site inspection scheduling and activities at declared facilities, resulting in fewer, better inspections. Such information-driven inspections are the logical evolution of inspection planning - making use of all available information to enhance scheduled and randomized inspections. Data collection and analysis approaches for unattended monitoring systems can be designed to protect sensitive information while enabling information-driven inspections. A number of such inspections within a predetermined range could reduce inspection frequency while providing an equal or greater level of deterrence against illicit activity, all while meeting operator and technology holder requirements and reducing inspector and operator burden. Three options for using unattended monitoring data to determine an information-driven inspection schedule are to (1) send all unattended monitoring data off-site, which will require advances in data analysis techniques to

  11. Wedges for ultrasonic inspection

    Energy Technology Data Exchange (ETDEWEB)

    Gavin, Donald A. (Rexford, NY)

    1982-01-01

    An ultrasonic transducer device is provided which is used in ultrasonic inspection of the material surrounding a threaded hole and which comprises a wedge of plastic or the like including a curved threaded surface adapted to be screwed into the threaded hole and a generally planar surface on which a conventional ultrasonic transducer is mounted. The plastic wedge can be rotated within the threaded hole to inspect for flaws in the material surrounding the threaded hole.

  12. Source Inspection Scheduling Calendar

    Science.gov (United States)

    Hollis, Brayden

    2011-01-01

    Quality is an essential component for creating flight hardware travelling through space since the hardware is extremely expensive and cannot be reworked or repaired once launched. An important step in this process is ensuring the quality of hardware procured from Jet Propulsion Laboratory's (JPL) suppliers. An important element of determining supplier quality is source inspection. Source inspections are performed at suppliers' facilities by JPL employeesto ensure that hardware characteristics are acceptable before being covered up and/or delivered to JPL.

  13. Wall Painting Investigation by Means of Non-invasive Terahertz Time-Domain Imaging (THz-TDI): Inspection of Subsurface Structures Buried in Historical Plasters

    Science.gov (United States)

    Dandolo, Corinna Ludovica Koch; Jepsen, Peter Uhd

    2016-02-01

    Characterization of subsurface features of wall paintings is important in conservation and technical art history as well as in building archaeology and architecture fields. In this study, an area of the apsidal wall painting of Nebbelunde Church (Rødby, Denmark) has been investigated by means of terahertz time-domain imaging (THz-TDI). Subsurface structures have been detected at different depths inside the lime-based plaster of the wall painting until approximately 1 cm from the surface. The surface morphology of the buried structures has been 3D imaged in detail, providing a substantial contribution in their characterization.

  14. Typical investigational medicinal products follow relatively uniform regulations in 10 European Clinical Research Infrastructures Network (ECRIN countries

    Directory of Open Access Journals (Sweden)

    Gluud Christian

    2012-03-01

    Full Text Available Abstract Background In order to facilitate multinational clinical research, regulatory requirements need to become international and harmonised. The EU introduced the Directive 2001/20/EC in 2004, regulating investigational medicinal products in Europe. Methods We conducted a survey in order to identify the national regulatory requirements for major categories of clinical research in ten European Clinical Research Infrastructures Network (ECRIN countries-Austria, Denmark, France, Germany, Hungary, Ireland, Italy, Spain, Sweden, and United Kingdom-covering approximately 70% of the EU population. Here we describe the results for regulatory requirements for typical investigational medicinal products, in the ten countries. Results Our results show that the ten countries have fairly harmonised definitions of typical investigational medicinal products. Clinical trials assessing typical investigational medicinal products require authorisation from a national competent authority in each of the countries surveyed. The opinion of the competent authorities is communicated to the trial sponsor within the same timelines, i.e., no more than 60 days, in all ten countries. The authority to which the application has to be sent to in the different countries is not fully harmonised. Conclusion The Directive 2001/20/EC defined the term 'investigational medicinal product' and all regulatory requirements described therein are applicable to investigational medicinal products. Our survey showed, however, that those requirements had been adopted in ten European countries, not for investigational medicinal products overall, but rather a narrower category which we term 'typical' investigational medicinal products. The result is partial EU harmonisation of requirements and a relatively navigable landscape for the sponsor regarding typical investigational medicinal products.

  15. Inspection of tendons

    International Nuclear Information System (INIS)

    There is no reliable inspection method of tendons in use in Finland. In this research an inspection method was developed which can be applied when the sheath is of metallic material. The sheath is first revealed using a core cutter. A hole is then picked on the sheath and the condition of the injection grout and the tendons are inspected using an endoscope. A camera may be attached to the endoscope. To prevent the sheath from damaging during drilling a protective voltage is connected to the drill and the sheath is earthed. When the cutting edge hits the sheath the electric current is disconnected automatically. Experiments were made with the inspection method on three bridges one of which was still under construction and had no superstructure, one had just been constructed and one was 29 years old. The drillings for inspection were carried out on the top of the decks. The method worked as planned in all cases. In section 6 an example of corrosion classification is given which may be used when estimating whether the corrosion weakens the bearing capacity of the inspected tendons or not. (au) (1 ref., 25 figs.)

  16. The appropriateness of clinical microbiology laboratory investigations: a retrospective study of the cost and clinical relevance of specimen management and processing

    OpenAIRE

    Abdi, Yasin

    2012-01-01

    Each year, NHS clinical laboratories carry out more than 700 million laboratory tests, of which 50 million are microbiology investigations. Several studies have shown that between 25% and 40% of all tests sent to the laboratory are unnecessary, and up to 46% of ordered microbiology tests are inappropriate. In light of these accounts, the present study was undertaken to evaluate the process of microbiology specimen management in order to assess microbiology test utilisation and the appropriate...

  17. Pathological, clinical and biochemical investigation of naturally occurring pregnancy toxemia of sheep

    OpenAIRE

    Kabakci N.; Yarim G.; Yarim M.; Duru O.; Yagci B.; Kisa U.

    2003-01-01

    A sick ewe in late pregnancy presented with clinical incoordination lipping, amaurosis, head tilt gait and nervous symptoms such as circling movements. A smell of ketones on the breath was detected. The sick animal died during clinical examination and, together with three more dead animals belonging to the same flock, was submitted to the laboratory for necropsy. The uteri of all pregnant animals contained late-term twin fetuses. The most prominent lesion was extensive fatty infiltration of t...

  18. Inflammatory bowel disease in children--clinical, endoscopic, radiologic and histopathologic investigation.

    OpenAIRE

    Seo, J. K.; Yeon, K. M.; Chi, J. G.

    1992-01-01

    This paper reviews our five years' clinical experience (1987 to 1991) of 22 patients with inflammatory bowel disease (IBD). There were 12 patients with Crohn's disease and 10 patients with ulcerative colitis. The mean age at diagnosis was 8.7 years (2 to 14 years). Clinical impressions before referral were chronic diarrhea in 11, irritable bowel syndrome in 5, colon polyp in 4, lymphoma in 3, intestinal tuberculosis in 2, amoebic colitis in 2, ulcerative colitis in 2 children and other diseas...

  19. Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects.

    Science.gov (United States)

    Mukhopadhyay, Subhadip; Sinha, Niharika; Das, Durgesh Nandini; Panda, Prashanta Kumar; Naik, Prajna Paramita; Bhutia, Sujit Kumar

    2016-08-01

    Oncophagy (cancer-related autophagy) has a complex dual character at different stages of tumor progression. It remains an important clinical problem to unravel the reasons that propel the shift in the role of oncophagy from tumor inhibition to a protective mechanism that shields full-blown malignancy. Most treatment strategies emphasize curbing protective oncophagy while triggering the oncophagy that is lethal to tumor cells. In this review, we focus on the trends in current therapeutics as well as various challenges in clinical trials to address the oncophagic dilemma and evaluate the potential of these developing therapies. A detailed analysis of the clinical and pre-clinical scenario of the anticancer medicines highlights the various inducers and inhibitors of autophagy. The ways in which tumor stage, the microenvironment and combination drug treatment continue to play an important tactical role are discussed. Moreover, autophagy targets also play a crucial role in developing the best possible solution to this oncophagy paradox. In this review, we provide a comprehensive update on the current clinical impact of autophagy-based cancer therapeutic drugs and try to lessen the gap between translational medicine and clinical science. PMID:26743568

  20. Inspections in veterinary medicine 2005; Veterinaerinspektioner 2005

    Energy Technology Data Exchange (ETDEWEB)

    Joensson, Helene

    2006-11-15

    In Sweden 300 veterinary clinics have a license for x-ray diagnostics. Six of them also have a license for nuclear medicine. During 2005 eight clinics were inspected and the results show that the radiation protection in veterinary medicine can be improved. No clinic fulfilled the regulations of categorization of workplaces and workers (SSI FS 1998:3). Half of the clinics had no Swedish manual to the x-ray equipment and just as many had not performed the annual function check. Obviously, there is a need for more information to staff in veterinary medicine.

  1. Optimisation of sonic thermographic inspection

    Science.gov (United States)

    Tsoi, Kelly A.; Yousif, Khalid; Rajic, Nik; Powlesland, Ian

    2009-03-01

    A versatile and broad-field technique, sonic thermography uses high intensity acoustic waves to induce frictional heating at defect locations and the thermal signature is then detected using IR imaging. Sonic thermography has the potential to be used as a quantitative technique for difficult inspection problems. One example is the inspection of interference fit fasteners. In the case of poorly fitted interference fasteners, the acoustic waves induce relative motion between the fastener and host, causing frictional heating which can then be detected. The preliminary results of an inspection of interference fit levels in fastened metallic plates, reminiscent of the F-111C wing skin, are discussed. By improving the repeatability of the acoustic energy transfer, the heat detected using the IR thermographic system can be correlated to the interference fit levels of the fasteners. The results provide encouragement for the development of a quantitative assessment capability, however one of the remaining critical issues, which has hindered the use of sonic thermography as a quantitative technique, is the poor repeatability of acoustic excitations. This paper will also report on an experimental study which investigates this repeatability issue, in particular the role of the interface material used between the horn tip and the structure to enhance energy transfer.

  2. First report on seroepidemiological and clinical investigation of cat infection with Bartonella henselae in the area of Novi Sad, Serbia

    Directory of Open Access Journals (Sweden)

    Potkonjak A.

    2011-01-01

    Full Text Available Cat Scratch Disease (CSD is an infective disease of animals and humans caused with Bartonella henselae. Prevalence of infection varies between 0 and 68% depending on different population of cats and geographical region. Naturally infected cats are often clinically healthy and are inapparent germ carriers. In this investigation 40 cats from the area of Novi Sad were analyzed. After the epidemiological questionnaire was made, all cats were clinically investigated. To determine the presence of specific antibodies of class G on Bartonella henselae the method of indirect immunofluorescence was used. For the first time in Serbia, in the area of Novi Sad municipality the infection caused by Bartonella henselae in the population of cats was detected. Prevalence of specific antibodies of class IgG on Bartonella henselae antigen in the population of cats was 57%. The most common clinical manifestations in seropositive cats were gingivitis and lymphoadenopathy.

  3. Clinical impact of diagnostic SPET investigations with a dopamine re-uptake ligand

    Energy Technology Data Exchange (ETDEWEB)

    Loekkegaard, Annemette [Department of Neurology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV (Denmark); Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, Copenhagen (Denmark); Werdelin, Lene M. [Department of Neurology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV (Denmark); Friberg, Lars [Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, Copenhagen (Denmark)

    2002-12-01

    The diagnosis of Parkinson's disease is based on clinical features with pathological verification. However, autopsy has been found to confirm a specialist diagnosis in only about 75% of cases. Especially early in the course of the disease, the clinical diagnosis can be difficult. Imaging of presynaptic dopamine transporters (DAT receptors) has provided a possible diagnostic probe in the evaluation of Parkinson's disease. The cocaine analogue [{sup 123}I]-2-{beta}-carboxymethoxy-3-{beta}(4-iodophenyl)tropane ([{sup 123}I]-{beta}-CIT) is one of several radioligands that have been developed for single-photon emission tomography (SPET). The purpose of this study was to evaluate the impact of [{sup 123}I]-{beta}-CIT SPET on the diagnosis and clinical management of patients with a primary, tentative diagnosis of parkinsonism. We undertook a retrospective evaluation of the clinical records of 90 consecutive patients referred to [{sup 123}I]-{beta}-CIT SPET from the neurological department, Bispebjerg Hospital. In 58 subjects the scans revealed altered tracer uptake consistent with Parkinson's disease, progressive supranuclear palsy and multiple system atrophy. A significant change in the management or treatment because of the scan was found in 25 patients (28%). The sensitivity of the examination was 97% and the specificity 83%. In conclusion, a significant clinical impact of DAT receptor SPET imaging was found. DAT receptor imaging is a useful diagnostic probe in patients with a possible diagnosis of parkinsonism. (orig.)

  4. Incore inspection device

    International Nuclear Information System (INIS)

    The device of the present invention can inspect surfaces of equipments in reactor water in a nuclear reactor in a state of atmospheric air. Namely, an inspection device is movable forwardly and backwardly in a water-proof vessel. An annular sucker with pleats is disposed to the outer side of a lid of the water-proof vessel. A television camera for an under water monitoring is disposed to the inner side of the lid of the water-proof vessel by way of a partitioning wall with lid. Transferring screws are disposed at the back and on the side of the water-proof vessel. In the device having such a constitution, (1) the inside of the water-proof vessel is at first made water-tight by closing the partitioning wall with lid, (2) the back and the side screws are operated by the guide of the underwater monitoring television camera, to transfer the water-proof vessel to the surface of the reactor core to be inspected, (3) the annular sucker with pleats is urged on the surface to be inspected by the back screw, to fix the water-proof vessel, (4) reactor water in a space of the annular sucker with pleats is discharged and replaced with air, and (5) the lid of the partition wall with lid is opened and the inspection device is disposed at a position of the underwater monitoring television camera, to inspect the surface to be inspected in a state of atmospheric air. (I.S.)

  5. Inspection Strategies for Concrete Bridges

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Thoft-Christensen, Palle

    In this paper an optimal inspection strategy for concrete bridges based on periodic routine and detailed inspections is presented. The failure mode considered is corrosion of the reinforcement due to chlorides. A simple modelling of the corrosion and of the inspection strategy is presented. The...... optimal inspection strategy is determined from an optimization problem, where the design variables are time intervals between detailed inspections and the concrete cover. The strategy is illustrated on a simple structure, namely a reinforced concrete beam....

  6. Musculoskeletal disorders of the neck and upper limb among sewing machine operators: a clinical investigation.

    Science.gov (United States)

    Andersen, J H; Gaardboe, O

    1993-12-01

    One hundred and seven women participated in a clinical study of an age-stratified random sample of sewing machine operators compared to a group of auxiliary nurses and home helpers. Four groups, according to years of being a sewing machine operator, consisted of: (controls) 25; (0-7 years) 21; (8-15 years) 25; and (more than 15 years) 36. The numbers of the main clinical diagnoses in the four groups were: cervicobrachial fibromyalgia (myofascial pain syndrome) 2, 4, 11, 24; cervical syndrome 0, 1, 3, 10; and rotator cuff syndrome 1, 1, 6, 11. The observed exposure-response relationship between clinical outcomes and years as a sewing machine operator was maintained when adjusting for current exposure to musculoskeletal strain and other potential confounders. Muscle palpation proved to be a reproducible examination with kappa values around 0.70. PMID:8311099

  7. 77 FR 69631 - Draft Guidance for IRBs, Clinical Investigators, and Sponsors: IRB Responsibilities for Reviewing...

    Science.gov (United States)

    2012-11-20

    ... Reducing Burden, Delay, and Ambiguity for Investigators,'' in the Federal Register of July 26, 2011 (76 FR... Sponsors: IRB Responsibilities for Reviewing the Qualifications of Investigators, Adequacy of Research... Responsibilities for Reviewing the Qualifications of Investigators, Adequacy of Research Sites, and...

  8. Investigations of efficacy of intramammary applied antimicrobials and glucocorticosteroides in the treatment of subclinical and clinical mastitis in cows

    Directory of Open Access Journals (Sweden)

    Vakanjac Slobodanka

    2013-01-01

    Full Text Available Inflammation of the mammary gland, mastitis in cows, presents one of the most acute problems in intensive dairy production, inflicting huge economic losses. In the course of one year, 80 samples were taken at investigated farms from udder quarters of cows with clinical mastitis and 160 samples from udder quarters of cows with subclinical mastitis. The efficacy of three preparations, A, B, and C, was examined in the treatment of clinical and subclinical mastitis in cows. The investigations indicate that antibiotic preparation A (neomycin, polimixine B, oleandomycin and prednisolone exhibited a greater efficacy in the treatment of clinical mastitis caused by Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis and Micrococcus sp., but a smaller efficacy in the treatment of subclinical mastitis caused by Staphylococcus aureus. Preparation B (amoxicillin, clavulanic acid and prednisolone exhibited a higher efficacy in the treatment of clinical mastitis caused by Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis and Micrococcus, but a weaker effect in the treatment of subclinical mastitis caused by Staphylococcus aureus. Preparation C (procaine penicillin G, streptomycin, neomycin sulfate and prednisolone acetate exihibited efficacy in the treatment of clinical and subclinical mastitis caused by Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, Micrococcus, Staphylococcus aureus and Esherichie coli. [Projekat Ministarstva nauke Republike Srbije, br. III 46002: Molekularno-genetička i ekofiziološka istraživanja u zaštiti autohtonih animalnih genetičkih resursa, očuvanju dobrobiti, zdravlja i reprodukcije gajenih životinja i proizvodnji bezbedne hrane

  9. Application of Laser Profilometry to inspection of SMART SGC tube

    International Nuclear Information System (INIS)

    The application of the laser profilometry technique to inspection of tube is investigated for the in-service inspection of the SMART SGC tube. The state of the art of the laser tube inspection apparatus is analyzed for detection of ovality and inner-surface defect of the tube. A laser profilometer sensor system for measuring inner-diameter of the tube is instrumented for the experimental study of the laser measuring sensor. Using the new developed laser profilometer and a commercial laser tube inspection sensor system, the application of the laser profilometer system to inspection of the tube inner surface is investigated experimentally. As conclusion, the laser profilometer sensor can be applied to inspection of the tube successfully

  10. Piping inspection round robin

    International Nuclear Information System (INIS)

    The piping inspection round robin was conducted in 1981 at the Pacific Northwest National Laboratory (PNNL) to quantify the capability of ultrasonics for inservice inspection and to address some aspects of reliability for this type of nondestructive evaluation (NDE). The round robin measured the crack detection capabilities of seven field inspection teams who employed procedures that met or exceeded the 1977 edition through the 1978 addenda of the American Society of Mechanical Engineers (ASME) Section 11 Code requirements. Three different types of materials were employed in the study (cast stainless steel, clad ferritic, and wrought stainless steel), and two different types of flaws were implanted into the specimens (intergranular stress corrosion cracks (IGSCCs) and thermal fatigue cracks (TFCs)). When considering near-side inspection, far-side inspection, and false call rate, the overall performance was found to be best in clad ferritic, less effective in wrought stainless steel and the worst in cast stainless steel. Depth sizing performance showed little correlation with the true crack depths

  11. Safety System functional inspections

    International Nuclear Information System (INIS)

    The basic purpose of Safety System Functional Inspections (SSFI) is to carry out an impartial and independent assessment of previously selected safety systems, in order to determine whether they have been installed, tested, operated and managed in accordance with the original Design Bases and with the applicable regulatory requirements, codes and standards, that is, their Licensing Bases. These functional inspections are performed within the framework established by the Quality Assurance Programmes of electric utility owners, and in accordance with specifically prepared procedures previously approved for each power plant. These SSFIs verify, for safety systems and their support systems (eg HVAC systems, etc), the operational availability of inspected systems of components by researching and determining whether there have been generic or programmed deficiencies in the course of Operation, that will prevent the systems from adequately performing the functions for which they were originally designed. PSA and IPE results are used as the basis for selecting the systems that should undergo functional inspections. As a consequence of these SSFIs, final reports will be prepared, summarizing actions taken at the plants and contemplating discrepancies or deviations detected during inspection. The necessary corrective actions for these discrepancies will be indicated in either the design documentation or the Operation and Maintenance Procedures. (Author)

  12. Inspection device in liquid

    International Nuclear Information System (INIS)

    The present invention provides an inspection device in PWR reactor core in which inspection operations are made efficient by stabilizing a posture of the device in front-to-back, vertical and left-to-right directions by a simple structure. When the device conducts inspection while running in liquid, the front and the back directions of the device main body are inspected using a visual device while changing the posture by operating a front-to-back direction propulsion device and a right-to-left direction propulsion device, and a vertical direction propulsion device against to rolling, pitching and yawing of the device main body. In this case, a spherical magnet moves freely in the gravitational direction in a vibration-damping fluid in a non-magnetic spherical shell following the change of the posture of the device main body, in which the vibrations due to the movement of the spherical magnet is settled by the vibration-damping fluid thereby stabilizing the posture of the device main body. At a typical inspection posture, the settling effect is enhanced by the attraction force between the spherical magnets in the spherical shell and each of magnetic force-attracted magnetic members disposed to the outer circumference of the shell, and the posture of the device main body can be confirmed in front-to-back, right-to-left and vertical directions by each of the posture confirming magnetic sensors. (N.H.)

  13. The role of ultrasound simulators in education: an investigation into sonography student experiences and clinical mentor perceptions.

    Science.gov (United States)

    Gibbs, Vivien

    2015-11-01

    Simulation as an effective pedagogy is gaining momentum at all levels of health care education. Limited research has been undertaken on the role of simulated learning in health care and further evaluation is needed to explore the quality of learning opportunities offered, and their effectiveness in the preparation of students for clinical practice. This study was undertaken to explore ways of integrating simulation-based learning into sonography training to enhance clinical preparation. A qualitative study was undertaken, using interviews to investigate the experiences of a group of sonography students after interacting with an ultrasound simulator. The perceptions of their clinical mentors on the effectiveness of this equipment to support the education and development of sonographers were also explored. The findings confirm that ultrasound simulators provide learning opportunities in an unpressurised environment, which reduces stress for the student and potential harm to patients. Busy clinical departments acknowledge the advantages of opportunities for students to acquire basic psychomotor skills in a classroom setting, thereby avoiding the inevitable reduction in patient throughput which results from clinical training. The limitations of simulation equipment to support the development of the full range of clinical skills required by sonographers were highlighted and suggestions made for more effective integration of simulation into the teaching and learning process. Ultrasound simulators have a role in sonography education, but continued research needs to be undertaken in order to develop appropriate strategies to support students, educators and mentors to effectively integrate this methodology. PMID:27433260

  14. Early clinical investigation of sulofenur with a daily schedule in advanced solid tumours

    DEFF Research Database (Denmark)

    Krarup-Hansen, A; Pedersen, H; Andersen, E;

    1997-01-01

    Sulofenur, a sulfonylurea, has demonstrated antitumour effect in preclinical studies. A phase I trial was initiated to study the clinical aspects. Sulofenur was given p.o. daily for a period of 28 days in 5-week courses. The initial dosage was 250 mg/m2 escalating to 700 mg/m2 daily with no dose ...

  15. An investigation on clinical, radiological and biochemical methods for assessing periodontitis activity

    International Nuclear Information System (INIS)

    In order to recognize in which stage rapidly progressing destruction of periodontal ligament fibers occurs, a number of diagnostic methods are studied in this thesis. It turns out that the actual much utilized clinical methods can not be improved while radiological and biochemical diagnositic methods are much more promising. 106 refs.; 20 figs.; 36 tabs

  16. 78 FR 60291 - Investigational Device Exemptions for Early Feasibility Medical Device Clinical Studies...

    Science.gov (United States)

    2013-10-01

    ... program for early feasibility study IDE applications (November 10, 2011, 76 FR 70152) to solicit... feasibility study IDE application and explains the requirements applicable to modifications to the device design or clinical study protocol during the early feasibility study. DATES: Submit either electronic...

  17. An Empirical Investigation of Group Treatment for a Clinical Population of Adult Female Incest Survivors.

    Science.gov (United States)

    Saxe, Brenda J.; Johnson, Susan M.

    1999-01-01

    Empirically assesses the effectiveness of a group treatment program on intrapersonal symptomatology and interpersonal difficulties in a clinical population of women with a history of incest. Results indicate that a time-limited group, which focuses on the original trauma, is effective in reducing intrapersonal symptomatology for women with a…

  18. Quality of clinical trials: A moving target

    Directory of Open Access Journals (Sweden)

    Arun Bhatt

    2011-01-01

    Full Text Available Quality of clinical trials depends on data integrity and subject protection. Globalization, outsourcing and increasing complexicity of clinical trials have made the target of achieving global quality challenging. The quality, as judged by regulatory inspections of the investigator sites, sponsors/contract research organizations and Institutional Review Board, has been of concern to the US Food and Drug Administration, as there has been hardly any change in frequency and nature of common deficiencies. To meet the regulatory expectations, the sponsors need to improve quality by developing systems with specific standards for each clinical trial process. The quality systems include: personnel roles and responsibilities, training, policies and procedures, quality assurance and auditing, document management, record retention, and reporting and corrective and preventive action. With an objective to improve quality, the FDA has planned new inspection approaches such as risk-based inspections, surveillance inspections, real-time oversight, and audit of sponsor quality systems. The FDA has partnered with Duke University for Clinical Trials Transformation Initiative, which will conduct research projects on design principles, data quality and quantity including monitoring, study start-up, and adverse event reporting. These recent initiatives will go a long way in improving quality of clinical trials.

  19. Advances in inspection automation

    Science.gov (United States)

    Weber, Walter H.; Mair, H. Douglas; Jansen, Dion; Lombardi, Luciano

    2013-01-01

    This new session at QNDE reflects the growing interest in inspection automation. Our paper describes a newly developed platform that makes the complex NDE automation possible without the need for software programmers. Inspection tasks that are tedious, error-prone or impossible for humans to perform can now be automated using a form of drag and drop visual scripting. Our work attempts to rectify the problem that NDE is not keeping pace with the rest of factory automation. Outside of NDE, robots routinely and autonomously machine parts, assemble components, weld structures and report progress to corporate databases. By contrast, components arriving in the NDT department typically require manual part handling, calibrations and analysis. The automation examples in this paper cover the development of robotic thickness gauging and the use of adaptive contour following on the NRU reactor inspection at Chalk River.

  20. Radiochemistry, pre-clinical studies and first clinical investigation of 90Y-labeled hydroxyapatite (HA) particles prepared utilizing 90Y produced by (n,γ) route

    International Nuclear Information System (INIS)

    Introduction: The scope of using no carrier added (NCA) 90Y [T1/2 = 64.1 h, Eβ(max) = 2.28 MeV] obtained from 90Sr/90Y generator in radiation synovectomy (RSV) is widely accepted. In the present study, the prospect of using 90Y produced by (n,γ) route in a medium flux research reactor for use in RSV was explored. Methods: Yttrium-90 was produced by thermal neutron irradiation of Y2O3 target at a neutron flux of ~ 1 × 1014 n/cm2.s for 14 d. The influence of various experimental parameters were systematically investigated and optimized to arrive at the most favorable conditions for the formulation of 90Y labeled hydroxyapatite (HA) using HA particles of 1–10 μm size range. An optimized kit formulation strategy was developed for convenient one-step compounding of 90Y-HA, which is easily adaptable at hospital radiopharmacy. The pre-clinical biological evaluation of 90Y-HA particles was studied by carrying out biodistribution and bioluminiscence imaging studies in Wistar rats. The first clinical investigation using the radiolabeled preparation was performed on a patient suffering from chronic arthritis in knee joint by administering 185 MBq 90Y-HA formulated at the hospital radiopharmacy deploying the proposed strategy. Results: Yttrium-90 was produced with a specific activity of 851 ± 111 MBq/mg and radionuclidic purity of 99.95 ± 0.02%. 90Y-labeled HA particles (185 ± 10 MBq doses) were formulated in high radiochemical purity (> 99%) and excellent in vitro stability. The preparation showed promising results in pre-clinical studies carried out in Wistar rats. The preliminary results of the first clinical investigation of 90Y-HA preparation in a patient with rheumatoid arthritis in knee joints demonstrated the effectiveness of the formulation prepared using 90Y produced via (n,γ) route in the management of the disease. Conclusion: The studies revealed that effective utilization of 90Y produced via (n,γ) route in a medium flux research reactor coupled with the

  1. NRU light water reflector inspections

    International Nuclear Information System (INIS)

    In 2009 May, the National Research Universal (NRU) calandria leaked. In the next year the calandria was inspected with six new techniques, repaired, and the repair inspected with four additional new techniques. The calandria is surrounded by a light water reflector vessel. Concerns that the same corrosion mechanism may have damaged the reflector vessel led to plans to inspect the full circumference of the reflector wall for corrosion damage, through a 64 mm diameter port, from 10 m away, while inspecting from the corroded surface. The ultrasonic technique is intended to produce a very fine inspection grid, through the corroded surface, using a very small probe body over the approximately 5 m2 to be inspected. The calandria vessel inspections were successfully performed, in a short time period, under difficult conditions. This paper will discuss Operating Experience (OPEX) from the 2009/2010 calandria wall inspections and industry dialogue that were applied to the Reflector Wall Inspection (RWI) project. Interaction with the CANDU Inspection Qualification Bureau (CIQB) on procedures, training plans, and mock-up training, led to improvements in how these activities were performed for the RWI project. Experience with shift turnover meetings led to improvements in how the inspection team captures lessons learned, trends issues, and eliminates reoccurring design and procedure problems. Experience with collected and analyzed data, inspection shift logs, and video captured from inspections and repairs, were used to improve inspection performance. Finally, OPEX from radiation/activation and the calibration process reduced dose through tool design and procedure changes. (author)

  2. Risk-Informed Decisions Optimization in Inspection and Maintenance

    International Nuclear Information System (INIS)

    The Risk-Informed Approach (RIA) used to support decisions related to inspection and maintenance program is considered. The use of risk-informed methods can help focus the adequate in-service inspections and control on the more important locations of complex dynamic systems. The focus is set on the highest risk measured as conditional core damage frequency, which is produced by the frequencies of degradation and final failure at different locations combined with the conditional failure consequence probability. The probabilities of different degradation states per year and consequences are estimated quantitatively. The investigation of inspection and maintenance process is presented as the combination of deterministic and probabilistic analysis based on general risk-informed model, which includes the inspection and maintenance program features. Such RIA allows an optimization of inspection program while maintaining probabilistic and fundamental deterministic safety requirements. The failure statistics analysis is used as well as the evaluation of reliability of inspections. The assumptions regarding the effectiveness of the inspection methods are based on a classification of the accessibility of the welds during the inspection and on the different techniques used for inspection. The probability of defect detection is assumed to depend on the parameters either through logarithmic or logit transformation. As example the modeling of the pipe systems inspection process is analyzed. The means to reduce a number of inspection sites and the cumulative radiation exposure to the NPP inspection personnel with a reduction of overall risk is presented together with used and developed software. The developed software can perform and administrate all the risk evaluations and ensure the possibilities to compare different options and perform sensitivity analysis. The approaches to define an acceptable level of risk are discussed. These approaches with appropriate software in

  3. Federal environmental inspections handbook

    International Nuclear Information System (INIS)

    This Federal Environmental Inspection Handbook has been prepared by the Department of Energy (DOE), Office of Environmental Guidance, RCRA/CERCLA Division (EH-231). It is designed to provide DOE personnel with an easily accessible compilation of the environmental inspection requirements under Federal environmental statutes which may impact DOE operations and activities. DOE personnel are reminded that this Handbook is intended to be used in concert with, and not as a substitute for, the Code of Federal Regulations (CFR). Federal Register (FR), and other applicable regulatory documents

  4. Inspection and test planning

    International Nuclear Information System (INIS)

    Purpose of Quality Plan - arrangement of all necessary tests or inspections as far as possible filted to certain components or systems. Subject of Quality Plan - precise determination of tests or inspections and - according to the actual safety significance - the certificates to be done. Disposition of Quality Plan - accommodation of tests to the actual state of fabrication. Application of Quality Plan - to any component or system that is regarded. Supervision of Employment - by authorized personnel of manufacturer, customer or authority providing exact employment of quality plan. Overservance of Instructions - certificates given by authorized personnel. (orig./RW)

  5. Methodology guideline for clinical studies investigating traditional Chinese medicine and integrative medicine: executive summary.

    Science.gov (United States)

    Liu, Jian-Ping; Chen, Ke-Ji

    2015-10-01

    This guideline aims to provide a methodological guidance for clinical studies in TCM and integrative medicine in terms of study design, execution, and reporting. The commonly used methods including experimental and observational methods were introduced in this guideline such as randomized clinical trials, cohort study, case-control study, case series, and qualitative method which can be incorporated into above quantitative methods. The guideline can be used for the evaluation of therapeutic effect of TCM therapies or their combination with conventional therapy. TCM therapy refers to one of the followings or their combination: herbal medicine, acupuncture, moxibustion, cupping, Taichi/Qigong, and Guasha,Tuina (therapeutic massage). It is also suitable for research and development of ethnopharmaceuticals or folk medicine. PMID:26615617

  6. An Intelligent Computerized Stretch Reflex Measurement System For Clinical And Investigative Neurology

    Science.gov (United States)

    Flanagan, P. M.; Chutkow, J. G.; Riggs, M. T.; Cristiano, V. D.

    1987-05-01

    We describe the design of a reliable, user-friendly preprototype system for quantifying the tendon stretch reflexes in humans and large mammals. A hand-held, instrumented reflex gun, the impactor of which contains a single force sensor, interfaces with a computer. The resulting test system can deliver sequences of reproducible stimuli at graded intensities and adjustable durations to a muscle's tendon ("tendon taps"), measure the impacting force of each tap, and record the subsequent reflex muscle contraction from the same tendon -- all automatically. The parameters of the reflex muscle contraction include latency; mechanical threshold; and peak time, peak magnitude, and settling time. The results of clinical tests presented in this paper illustrate the system's potential usefulness in detecting neurologic dysfunction affecting the tendon stretch reflexes, in documenting the course of neurologic illnesses and their response to therapy, and in clinical and laboratory neurologic research.

  7. Opinions and perceptions regarding the impact of new regulatory guidelines: A survey in Indian Clinical Trial Investigators

    Directory of Open Access Journals (Sweden)

    Rashmi Kadam

    2016-01-01

    Full Text Available Background: Clinical research in India experienced dramatic changes with series of stringent guidelines introduced by regulatory authorities. These guidelines posed significant challenges for the clinical trial industry. Objective: To assess the perceptions and opinion of Indian Investigators about the new regulatory guidelines. Methods: We developed a survey questionnaire on recent regulatory guidelines which was hosted on a web portal. Seventy-three investigators from India participated in the survey. Results: Central registration of Ethics Committees (ECs was agreed by 90.1% participants, 76.8% participants agreed to compensation of subjects for study related Serious Adverse Events (SAE's. The compulsion to include government sites in clinical trials was not agreed by 49.3% participants while 21.2% agreed to it. Restriction on a number of trials per investigator was agreed by 49.3% of participants while 40.9% disagreed. Participants (50.7% disagreed to the introduction of audio-video (AV recording of informed consent, 36.6% agreed and 12.7% were neutral. Discussion: Participants observed that post central registration; ECs have improved systems with adequate member composition, functional Standard Operating Procedures, and timely approvals. Participants agreed that compensation of study related SAE's would assure subject protection and safety. The introduction of AV consenting was strongly debated sighting sociocultural issues in the implementation of the same. Conclusion: Participants endorsed guidelines pertaining to the central registration of ECs, SAE related compensation. Restrictions on a number of trials per investigator and AV consenting were debated ardently. The response of the survey participants who are clinical trial investigators in India showed general acceptance, effectiveness and anticipated compliance to the new regulatory guidelines.

  8. Opinions and perceptions regarding the impact of new regulatory guidelines: A survey in Indian Clinical Trial Investigators

    Science.gov (United States)

    Kadam, Rashmi; Borde, Sanghratna; Madas, Sapna; Nagarkar, Aarti; Salvi, Sundeep; Limaye, Sneha

    2016-01-01

    Background: Clinical research in India experienced dramatic changes with series of stringent guidelines introduced by regulatory authorities. These guidelines posed significant challenges for the clinical trial industry. Objective: To assess the perceptions and opinion of Indian Investigators about the new regulatory guidelines. Methods: We developed a survey questionnaire on recent regulatory guidelines which was hosted on a web portal. Seventy-three investigators from India participated in the survey. Results: Central registration of Ethics Committees (ECs) was agreed by 90.1% participants, 76.8% participants agreed to compensation of subjects for study related Serious Adverse Events (SAE's). The compulsion to include government sites in clinical trials was not agreed by 49.3% participants while 21.2% agreed to it. Restriction on a number of trials per investigator was agreed by 49.3% of participants while 40.9% disagreed. Participants (50.7%) disagreed to the introduction of audio-video (AV) recording of informed consent, 36.6% agreed and 12.7% were neutral. Discussion: Participants observed that post central registration; ECs have improved systems with adequate member composition, functional Standard Operating Procedures, and timely approvals. Participants agreed that compensation of study related SAE's would assure subject protection and safety. The introduction of AV consenting was strongly debated sighting sociocultural issues in the implementation of the same. Conclusion: Participants endorsed guidelines pertaining to the central registration of ECs, SAE related compensation. Restrictions on a number of trials per investigator and AV consenting were debated ardently. The response of the survey participants who are clinical trial investigators in India showed general acceptance, effectiveness and anticipated compliance to the new regulatory guidelines.

  9. Frequency, Clinical Correlates, and Ratings of Behavioral Changes in Primary Brain Tumor Patients: A Preliminary Investigation

    OpenAIRE

    Grahame K Simpson; Koh, Eng-Siew; Whiting, Diane; Wright, Kylie M.; Simpson, Teresa; Firth, Rochelle; Gillett, Lauren; Younan, Kathryn

    2015-01-01

    Purpose Few studies have addressed the specific behavioral changes associated with primary brain tumor (PBT). This paper will report on the frequency and demographic/clinical correlates of such behaviors, and the reliability of rating such behaviors among people with PBT, family informants, and clinicians. The association of behavioral changes and patient functional status will also be discussed. Methods A total of 57 patients with 37 family informants were recruited from two large...

  10. Investigation of competencies of nurses in disaster response by utilizing objective structured clinical examination

    OpenAIRE

    Bahrami, Masoud; Aliakbari, Fatemeh; Aein, Fereshteh

    2014-01-01

    Background: Nurses are members of the health care team for crisis response. Identifying nurses’ capability in responding to a disaster and promoting their preparedness will lead to effective use of human resources and decreasing the detrimental effects of disaster. The purpose of this article was to determine emergency nurses’ competences in triage, life support, and basic clinical skills in disaster response. Materials and Methods: This study was a descriptive study in which 40 emergency nur...

  11. PET/SPECT molecular imaging in clinical neuroscience: recent advances in the investigation of CNS diseases

    OpenAIRE

    Lu, Feng-Mei; Yuan, Zhen

    2015-01-01

    Molecular imaging is an attractive technology widely used in clinical practice that greatly enhances our understanding of the pathophysiology and treatment in central nervous system (CNS) diseases. It is a novel multidisciplinary technique that can be defined as real-time visualization, in vivo characterization and qualification of biological processes at the molecular and cellular level. It involves the imaging modalities and the corresponding imaging agents. Nowadays, molecular imaging in n...

  12. A psychometric investigation of "macroscopic" speech measures for clinical and psychological science.

    Science.gov (United States)

    Cohen, Alex S; Renshaw, Tyler L; Mitchell, Kyle R; Kim, Yunjung

    2016-06-01

    The analysis of vocal expression is a critical endeavor for psychological and clinical sciences and is an increasingly popular application for computer-human interfaces. Despite this, and despite advances in the efficiency, affordability, and sophistication of vocal analytic technologies, there is considerable variability across studies regarding what aspects of vocal expression are studied. Vocal signals can be quantified in a myriad of ways, and their underlying structure, at least with respect to "macroscopic" measures from extended speech, is presently unclear. To address this issue, we evaluated the psychometric properties-notably, the structural and construct validity-of a systematically defined set of global vocal features. Our analytic strategy focused on (a) identifying redundant variables among this set, (b) employing principal components analysis (PCA) to identify nonoverlapping domains of vocal expression, (c) examining the degrees to which the vocal variables are modulated as a function of changes in speech task, and (d) evaluating the relationship between the vocal variables and cognitive (i.e., verbal fluency) and clinical (i.e., depression, anxiety, and hostility) variables. Spontaneous speech samples from 11 independent studies of young adults (>60 s in length), employing one of three different speaking tasks, were examined (N = 1,350). Confounding variables (i.e., sex, ethnicity) were statistically controlled for. The PCA identified six distinct domains of vocal expression. Collectively, vocal expression (defined in terms of these domains) was modulated as a function of speech task and was related to the cognitive and clinical variables. These findings provide empirically grounded implications for the study of vocal expression in psychological and clinical sciences. PMID:25862539

  13. Investigation of ultra low-dose scans in the context of quantum-counting clinical CT

    Science.gov (United States)

    Weidinger, T.; Buzug, T. M.; Flohr, T.; Fung, G. S. K.; Kappler, S.; Stierstorfer, K.; Tsui, B. M. W.

    2012-03-01

    In clinical computed tomography (CT), images from patient examinations taken with conventional scanners exhibit noise characteristics governed by electronics noise, when scanning strongly attenuating obese patients or with an ultra-low X-ray dose. Unlike CT systems based on energy integrating detectors, a system with a quantum counting detector does not suffer from this drawback. Instead, the noise from the electronics mainly affects the spectral resolution of these detectors. Therefore, it does not contribute to the image noise in spectrally non-resolved CT images. This promises improved image quality due to image noise reduction in scans obtained from clinical CT examinations with lowest X-ray tube currents or obese patients. To quantify the benefits of quantum counting detectors in clinical CT we have carried out an extensive simulation study of the complete scanning and reconstruction process for both kinds of detectors. The simulation chain encompasses modeling of the X-ray source, beam attenuation in the patient, and calculation of the detector response. Moreover, in each case the subsequent image preprocessing and reconstruction is modeled as well. The simulation-based, theoretical evaluation is validated by experiments with a novel prototype quantum counting system and a Siemens Definition Flash scanner with a conventional energy integrating CT detector. We demonstrate and quantify the improvement from image noise reduction achievable with quantum counting techniques in CT examinations with ultra-low X-ray dose and strong attenuation.

  14. Inspective investigation on Atlantic pomfret (Brama raji

    Directory of Open Access Journals (Sweden)

    Antonio Panebianco

    2013-02-01

    Full Text Available The present study was carried out on 21 specimens of Brama raji collected at fish markets of Sicily and Calabria between april 2011 and march 2012. The detection of total Enterobacteriaceae, Vibrio spp. and Specific Spoilage Bacteria from gills, intestine, skin and muscle during storage (336h was carried out. 34 Vibrio spp. (rpoA+ strains were isolated from gills and skin. The subsequent identification of species by multiplex PCR (gene collagenase allowed to establish that 33 strains were V. alginolyticus and one was V. parahaemolyticus. The anatomopathological examination of muscle tissue showed that 15 specimens (71.x4% were positive for the presence of larvae of Gymnorhynchus gigas. The determination of TVB-N and TMA-N was made on muscle portions around the parasite, on larvae of G. gigas and on muscle portions parasite-free. The TVB-N and TMA-N contents of each sample were measured using the Conway microdiffusion method. The higher values of TVB-N (31.6 mg/100g and TMA-N (8.5 mg/100g were observed at 336 hours of storage. No statistically significant differences between muscle parasite-free and muscle around the parasite for TVB-N and TMA-N were observed during storage. Parasites of genus Koellikeria filicollis, Sphiriocephalus tergestinus and Anisakis spp. were also observed.

  15. Inspective investigation on Atlantic pomfret (Brama raji)

    OpenAIRE

    2013-01-01

    The present study was carried out on 21 specimens of Brama raji collected at fish markets of Sicily and Calabria between april 2011 and march 2012. The detection of total Enterobacteriaceae, Vibrio spp. and Specific Spoilage Bacteria from gills, intestine, skin and muscle during storage (336h) was carried out. 34 Vibrio spp. (rpoA+) strains were isolated from gills and skin. The subsequent identification of species by multiplex PCR (gene collagenase) allowed to establish that 33 strains were ...

  16. Inspection of Emergency Arrangements

    International Nuclear Information System (INIS)

    The Working Group on Inspection Practices (WGIP) was tasked by the NEA CNRA to examine and evaluate the extent to which emergency arrangements are inspected and to identify areas of importance for the development of good inspection practices. WGIP members shared their approaches to the inspection of emergency arrangements by the use of questionnaires, which were developed from the requirements set out in IAEA Safety Standards. Detailed responses to the questionnaires from WGIP member countries have been compiled and are presented in the appendix to this report. The following commendable practices have been drawn from the completed questionnaires and views provided by WGIP members: - RBs and their Inspectors have sufficient knowledge and information regarding operator's arrangements for the preparedness and response to nuclear emergencies, to enable authoritative advice to be given to the national coordinating authority, where necessary. - Inspectors check that the operator's response to a nuclear emergency is adequately integrated with relevant response organisations. - Inspectors pay attention to consider the integration of the operator's response to safety and security threats. - The efficiency of international relations is checked in depth during some exercises (e.g. early warning, assistance and technical information), especially for near-border facilities that could lead to an emergency response abroad. - RB inspection programmes consider the adequacy of arrangements for emergency preparedness and response to multi-unit accidents. - RBs assess the adequacy of arrangements to respond to accidents in other countries. - The RB's role is adequately documented and communicated to all agencies taking part in the response to a nuclear or radiological emergency. - Inspectors check that threat assessments for NPPs have been undertaken in accordance with national requirements and that up-to-date assessments have been used as the basis for developing emergency plans for

  17. Cleveland Clinic Lerner College of Medicine: an innovative approach to medical education and the training of physician investigators.

    Science.gov (United States)

    Fishleder, Andrew J; Henson, Lindsey C; Hull, Alan L

    2007-04-01

    Cleveland Clinic Lerner College of Medicine (CCLCM) is an innovative, five-year medical education track within Case Western Reserve University School of Medicine (Case) with a focused mission to attract and educate a limited number of highly qualified persons who seek to become physician investigators. CCLCM curriculum governance, faculty appointments and promotions, and admissions committees are integrated with respective Case committees. The CCLCM curriculum is based on faculty-defined professional attributes that graduates are expected to develop. These attributes were used to create curricular and assessment principles that guided the development of an integrated basic science, clinical science, and research curriculum, conducted in an active learning environment. An organ-system approach is used to solidify an understanding of basic science discipline threads in the context of relevant clinical problems presented in PBL and case-based discussion formats. Clinical skills are introduced in the first year as part of the two-year longitudinal experience with a family practice or internal medicine physician. The research program provides all students with opportunities to learn and experience basic and translational research and clinical research before selecting a research topic for their 12- to 15-month master-level thesis project. All Case students participate in required and elective clinical curriculum after the second year, but CCLCM students return to the Cleveland Clinic on selected Friday afternoons for program-specific research and professionalism-learning activities. A unique portfolio-based assessment system is used to assess student achievements in nine competency areas, seven of which reflect the Accreditation Council for Graduate Medical Education competencies. PMID:17414197

  18. Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam.

    Science.gov (United States)

    Reese, Melinda J; Bowers, Gary D; Humphreys, Joan E; Gould, Elizabeth P; Ford, Susan L; Webster, Lindsey O; Polli, Joseph W

    2016-01-01

    1. Cabotegravir (CAB; GSK1265744) is a potent HIV integrase inhibitor in clinical development as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. 2. This work investigated if CAB was a substrate for efflux transporters, the potential for CAB to interact with drug-metabolizing enzymes and transporters to cause clinical drug interactions, and the effect of CAB on the pharmacokinetics of midazolam, a CYP3A4 probe substrate, in humans. 3. CAB is a substrate for Pgp and BCRP; however, its high intrinsic membrane permeability limits the impact of these transporters on its intestinal absorption. 4. At clinically relevant concentrations, CAB did not inhibit or induce any of the CYP or UGT enzymes evaluated in vitro and had no effect on the clinical pharmacokinetics of midazolam. 5. CAB is an inhibitor of OAT1 (IC50 0.81 µM) and OAT3 (IC50 0.41 µM) but did not or only weakly inhibited Pgp, BCRP, MRP2, MRP4, MATE1, MATE2-K, OATP1B1, OATP1B3, OCT1, OCT2 or BSEP. 6. Based on regulatory guidelines and quantitative extrapolations, CAB has a low propensity to cause clinically significant drug interactions, except for coadministration with OAT1 or OAT3 substrates. PMID:26340566

  19. Inspection Technology, Detection and Compliance: Evidence from Florida Restaurant Inspections

    OpenAIRE

    Jin, Ginger Zhe; Lee, Jungmin

    2013-01-01

    In this article, we show that a small innovation in inspection technology can make substantial differences in inspection outcomes. For restaurant hygiene inspections, the state of Florida has introduced a handheld electronic device, the portable digital assistant (PDA), which reminds inspectors of 1,000 potential violations that may be checked for. Using inspection records from July 2003 to June 2009, we find that the adoption of PDA led to 11% more detected violations and subsequently restau...

  20. Clinical Research and the Training of Host Country Investigators: Essential Health Priorities for Disease-Endemic Regions

    OpenAIRE

    Koita, Ousmane A.; Murphy, Robert L.; Fongoro, Saharé; Diallo, Boubakar; Doumbia, Seydou O.; Traoré, Moussa; Krogstad, Donald J.

    2016-01-01

    The health-care needs and resources of disease-endemic regions such as west Africa have been a major focus during the recent Ebola outbreak. On the basis of that experience, we call attention to two priorities that have unfortunately been ignored thus far: 1) the development of clinical research facilities and 2) the training of host country investigators to ensure that the facilities and expertise necessary to evaluate candidate interventions are available on-site in endemic regions when and...

  1. A multilevel investigation of inequalities in clinical and psychosocial outcomes for women after breast cancer

    Directory of Open Access Journals (Sweden)

    Aitken Joanne F

    2011-09-01

    Full Text Available Abstract Background In Australia, breast cancer is the most common cancer affecting Australian women. Inequalities in clinical and psychosocial outcomes have existed for some time, affecting particularly women from rural areas and from areas of disadvantage. We have a limited understanding of how individual and area-level factors are related to each other, and their associations with survival and other clinical and psychosocial outcomes. Methods/Design This study will examine associations between breast cancer recurrence, survival and psychosocial outcomes (e.g. distress, unmet supportive care needs, quality of life. The study will use an innovative multilevel approach using area-level factors simultaneously with detailed individual-level factors to assess the relative importance of remoteness, socioeconomic and demographic factors, diagnostic and treatment pathways and processes, and supportive care utilization to clinical and psychosocial outcomes. The study will use telephone and self-administered questionnaires to collect individual-level data from approximately 3, 300 women ascertained from the Queensland Cancer Registry diagnosed with invasive breast cancer residing in 478 Statistical Local Areas Queensland in 2011 and 2012. Area-level data will be sourced from the Australian Bureau of Statistics census data. Geo-coding and spatial technology will be used to calculate road travel distances from patients' residence to diagnostic and treatment centres. Data analysis will include a combination of standard empirical procedures and multilevel modelling. Discussion The study will address the critical question of: what are the individual- or area-level factors associated with inequalities in outcomes from breast cancer? The findings will provide health care providers and policy makers with targeted information to improve the management of women with breast cancer, and inform the development of strategies to improve psychosocial care for women

  2. Automated radiosynthesis of [{sup 11}C]morphine for clinical investigation

    Energy Technology Data Exchange (ETDEWEB)

    Fan Jinda [Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd. St. Louis, MO 63110 (United States); Meissner, Konrad [Department of Anesthesiology, Washington University School of Medicine, 510 South Kingshighway Blvd. St. Louis, MO 63110 (United States); Gaehle, Gregory G.; Li Shihong [Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd. St. Louis, MO 63110 (United States); Kharasch, Evan D. [Department of Anesthesiology, Washington University School of Medicine, 510 South Kingshighway Blvd. St. Louis, MO 63110 (United States); Mach, Robert H. [Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd. St. Louis, MO 63110 (United States); Tu Zhude, E-mail: tuz@mir.wustl.ed [Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd. St. Louis, MO 63110 (United States)

    2011-02-15

    To meet a multiple-dose clinical evaluation of the P-gp modulation of [{sup 11}C]morphine delivery into the human brain, radiosynthesis of [{sup 11}C]morphine was accomplished on an automated system by N-methylation of normorphine with [{sup 11}C]CH{sub 3}I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45 min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26 Ci/{mu}mol (decay corrected to end-of-bombardment); radiochemical and chemical purities were >95% (n=28).

  3. Development and internal structure investigation of the Dimensional Clinical Personality Inventory

    OpenAIRE

    Lucas de Francisco Carvalho; Ricardo Primi

    2015-01-01

    This study aimed to develop a dimensional instrument to assess personality disorders based on Millon's theoretical perspective and on DSM-IV-TR diagnoses criteria, and seek validity evidence based on internal structure and reliability indexes of the factors. In order to do that, a self-report test composed of 215 items, the Dimensional Clinical Personality Inventory (DCPI) was developed and applied to 561 respondents aged between 18 and 90 years (M = 28,8; SD = 11.4), with 51.8% females. Expl...

  4. Additive Manufacturing Infrared Inspection

    Science.gov (United States)

    Gaddy, Darrell

    2014-01-01

    Additive manufacturing is a rapid prototyping technology that allows parts to be built in a series of thin layers from plastic, ceramics, and metallics. Metallic additive manufacturing is an emerging form of rapid prototyping that allows complex structures to be built using various metallic powders. Significant time and cost savings have also been observed using the metallic additive manufacturing compared with traditional techniques. Development of the metallic additive manufacturing technology has advanced significantly over the last decade, although many of the techniques to inspect parts made from these processes have not advanced significantly or have limitations. Several external geometry inspection techniques exist such as Coordinate Measurement Machines (CMM), Laser Scanners, Structured Light Scanning Systems, or even traditional calipers and gages. All of the aforementioned techniques are limited to external geometry and contours or must use a contact probe to inspect limited internal dimensions. This presentation will document the development of a process for real-time dimensional inspection technique and digital quality record of the additive manufacturing process using Infrared camera imaging and processing techniques.

  5. Decisions to withhold diagnostic investigations in nursing home patients with a clinical suspicion of venous thromboembolism.

    Directory of Open Access Journals (Sweden)

    Henrike J Schouten

    Full Text Available This study aimed to gather insights in physicians' considerations for decisions to either refer for- or to withhold additional diagnostic investigations in nursing home patients with a suspicion of venous thromboembolism.Our study was nested in an observational study on diagnostic strategies for suspected venous thromboembolism in nursing home patients. Patient characteristics, bleeding-complications and mortality were related to the decision to withhold investigations. For a better understanding of the physicians' decisions, 21 individual face-to-face in-depth interviews were performed and analysed using the grounded theory approach.Referal for additional diagnostic investigations was forgone in 126/322 (39.1% patients with an indication for diagnostic work-up. 'Blind' anticoagulant treatment was initiated in 95 (75.4% of these patients. The 3 month mortality rates were higher for patients in whom investigations were withheld than in the referred patients, irrespective of anticoagulant treatment (odds ratio 2.45; 95% confidence interval 1.40 to 4.29 but when adjusted for the probability of being referred (i.e. the propensity score, there was no relation of non-diagnosis decisions to mortality (odds ratio 1.75; 0.98 to 3.11. In their decisions to forgo diagnostic investigations, physicians incorporated the estimated relative impact of the potential disease; the potential net-benefits of diagnostic investigations and whether performing investigations agreed with established management goals in advance care planning.Referral for additional diagnostic investigations is withheld in almost 40% of Dutch nursing home patients with suspected venous thromboembolism and an indication for diagnostic work-up. We propose that, given the complexity of these decisions and the uncertainty regarding their indirect effects on patient outcome, more attention should be focused on the decision to either use or withhold additional diagnostic tests.

  6. 14 CFR 91.409 - Inspections.

    Science.gov (United States)

    2010-01-01

    ... detail— (i) An explanation of the progressive inspection, including the continuity of inspection... the name and address of the person responsible for scheduling the inspections required by the...

  7. Pathological, clinical and biochemical investigation of naturally occurring pregnancy toxemia of sheep

    Directory of Open Access Journals (Sweden)

    Kabakci N.

    2003-01-01

    Full Text Available A sick ewe in late pregnancy presented with clinical incoordination lipping, amaurosis, head tilt gait and nervous symptoms such as circling movements. A smell of ketones on the breath was detected. The sick animal died during clinical examination and, together with three more dead animals belonging to the same flock, was submitted to the laboratory for necropsy. The uteri of all pregnant animals contained late-term twin fetuses. The most prominent lesion was extensive fatty infiltration of the liver. Massive lipidosis and lipid vacuoles were seen in sections of the livers. In three brains, there was prominent vacuolation in the white matter. Urine analysis revealed ketonuria in most of the suspected sheep from the same flock. Serum glucose, cholesterol, high density lipoprotein cholesterol, and blood urea nitrogen concentrations were lower (p£0.05 and serum triglycerides aspartate aminotransferase and alanine aminotransferase activities were higher (p£0.05 in these sheep than in the controls. After a change of diet and treatment, with glucose and dexamethasone serum glucose levels significantly increased (p£0.001 and urine ketone bodies decreased but the other biocemical differences remained.

  8. Clinical and experimental investigation on small intestinal injury following radiation therapy for carcinoma of uterine cervix

    International Nuclear Information System (INIS)

    Radiation injury of the small bowel was observed in 6 of 460 patients with carcinoma of uterine cervix who were treated by radiation between April 1966 and December 1973 at Tokyo Women's Medical College, Department of Radiology. Three of these 6 patients were treated conservatively and the other 3 others underwent surgery but died subsequently. Clinically and surgically these 6 patients showed marked adhesions of intestinal loops, which may be accounted for by the radiation injury of the small bowel. Clinical experience has shown that it is necessary to use a small radiation field to decrease small bowel injury from radiation. An experiment using abdominal radiation in mice confirmed that LD sub(50/30) is larger with a center split, maintaining equal integral doses. In adult dogs, severe small bowel obstruction was observed with over 4000 rad irradiation. Small bowel injury was milder in case with center split, intracavitary irradiation, and small radiation field. It was concluded that center split is one of the methods of preventing radiation injury of the small bowel. (Evans, J.)

  9. Terbinafine hydrochloride nanovesicular gel: In vitro characterization, ex vivo permeation and clinical investigation.

    Science.gov (United States)

    AbdelSamie, Sara M; Kamel, Amany O; Sammour, Omaima A; Ibrahim, Shady M

    2016-06-10

    In this work, nanovesicular chitosan gels were prepared for dermal delivery of terbinafine hydrochloride (TBN HCl). Ethosomes and vesicles containing different types of penetration enhancers (PEs) viz. Terpenes (cineole and limonene), labrasol and transcutol were developed. The prepared vesicles were evaluated for physical characteristics as well as skin interaction. The selected vesicles were incorporated into chitosan gel. An in vivo animal study was done on rat induced superficial Candida infection model. Moreover, randomized double blind clinical study was done on patients to compare the effect of the selected nanovesicular gel against the market product. Results showed the formation of nearly spherical, mostly deformable vesicular systems with size range of 95.5-530nm, zeta potential range of -0.1 to 15mV and entrapment efficiency range of 20-96.7%. Penetration enhancer vesicles (PEVs) prepared with 4% limonene (ELI4) showed the highest percent of drug deposition in the skin (53%) and the highest local accumulation efficiency value (35.3). In vivo animal study showed that the lowest fungal burden produced with ELI4 chitosan gel. Clinical studies showed cure rate of 86% within 7days treatment in case of limonene nanovesicular gel compared to 20% for market product (Lamisil® cream). PMID:27072432

  10. An investigation on implementation of clinical governance: A case study of an Iranian hospital

    Directory of Open Access Journals (Sweden)

    Elahe Parsaamal

    2013-10-01

    Full Text Available Clinical Governance (CG generally aims to enhance the quality of clinical services, increases the accountability of those who are responsible for health affairs. This study examines the quality of presenting medical services in Dr. Shariati hospital in Tehran after executing the CG project. To attain the aforesaid goal, this research also surveys the implementation rate of CG in Dr. Shariati hospital based on the CG seven-pillar model. The study is a descriptive and cross-sectional research fulfilled in summer 2013. Statistical population contains the employees of Dr. Shariati hospital in Tehran and the research sample includes 80 people of the mentioned population who were selected, randomly. Data was gathered through a questionnaire and the experts confirmed its validity and the reliability was approved via Cronbach's alpha of 0.947 and then, the analysis was carried out by the SPSS software and T-test. The findings for each CG pillar in Dr. Shariati hospital have placed less than the medium amount and they are not in desirable level. The CG at the above-mentioned hospital places in a medium rank so that the efforts by the managers will create successful changes at the hospital; meanwhile, the managers will be able to utilize the CG method in systematic prediction of changeable priorities to present the best strategies for achievable performance of managerial techniques and processes.

  11. Investigation of the method and clinical usefulness of the 14CO2-glycocholate-breath-test

    International Nuclear Information System (INIS)

    14C-glycocholate breath-tests were performed in 22 clinical patients without gastrointestinal disorders, in 11 cases with M. Crohn of the ileum and in 8 patients, in whom an intestinal overgrowth with bacteria was suspected. Additional to the usual discontinuous measurement of the specific activity of 14CO2 the exhaled amount of CO2 and 14CO2 and 14C-serum activity were determined. No advantage was found in the determination of the latter; for 1) discontinuous measurement of the specific activity of 14CO2 was sufficient for detecting disturbed enterohepatic bile-salt circulation; and 2) measurement of 14C-serum-activity or 14C-activity in cholic acids or protein were of no help in differentiating between bacterial overgrowth and diseases of the ileum. There remained doubts regarding the clinical usefulness of the test. Low specifity and many positive tests in patients without corresponding symptoms require that therapeutical procedures in such patients are initiated with some reserve. (orig.)

  12. Interventional management of spine eosinophilic granuloma in children: preliminary investigation of its clinical value

    International Nuclear Information System (INIS)

    Objective: To assess the clinical value of interventional management in treating spine eosinophilic granuloma in children. Methods: Interventional therapies, including per cutaneous biopsy and percutaneous vertebroplasty (PVP), were carried out in three child patients with five pathologically-proved eosinophilic granuloma lesions, which were localized in the vertebrae. The clinical data were retrospectively analyzed. Visual analogue pain scale (VAS) and Oswesty disability index (ODI) were assessed before and after operation. Results: A total of four operations were successfully carried out in all of three patients. The mean VAS score reduced from 7 before treatment of 1 after treatment. The mean ODI decreased from preoperative 52.5% to postoperative 10.5%. During procedures no significant complications occurred except for cement leakage in some cases. Pain relief and daily activity were remarkably improved after treatment. All patients were followed up for 3 months to 5 years. Conclusion: For the treatment of spine eosinophilic granuloma in children, interventional techniques are mini-invasive, safe and effective therapeutic methods. (authors)

  13. The Clinical Investigation of Disparity of Utility Values Associated with Gallstone Disease: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Chung-Te Hsu

    2013-01-01

    Full Text Available Purpose. The utility evaluation was an effective method to incorporate all of the contributing variables for multiple diseases into one outcome measure. A cross-sectional study was conducted to assess the utility values associated with varying states of gallstone disease among outpatient clinics participants at a teaching hospital in Taipei, Taiwan. Methods. The utility values were measured by using time trade-off method. A total of 120 outpatient clinics participants (30 subjects with no gallstone disease, 30 subjects with single stone, 30 subjects with multiple stones, and 30 subjects with cholecystectomy evaluated utility values from January 1, 2006 to December 31, 2006. The diagnosis of gallstone disease was performed by a panel of specialists using ultrasound sonography. Results. The overall mean utility value was 0.89±0.13 (95% CI: 0.87–0.91 indicating that study participants were willing to trade about 11% (95% CI: 9–13% of their remaining life in return for being free of gallstone disease perpetually. The significant associated factors of utility values based on the multiple linear regression analysis were older age and different degrees of gallstone disease. Conclusion. Our results found that in addition to older age, multiple stones and cholecystectomy could influence utility values from the patient’s preference-based viewpoint.

  14. The continuing legacy of the Tuskegee Syphilis Study: considerations for clinical investigation.

    Science.gov (United States)

    Corbie-Smith, G

    1999-01-01

    The Tuskegee Study, an observational study of over 400 sharecroppers with untreated syphilis, was conducted by the U.S. Public Health Service to document the course of the disease in blacks, and racial differences in the clinical manifestations of syphilis. The men were not told they had syphilis, not given counseling on avoiding spread of the disease, and not given treatment throughout the course of the study. The study became the longest (1932-1972) nontherapeutic experiment on humans in the history of medicine, and has come to represent not only the exploitation of blacks in medical history, but the potential for exploitation of any population that may be vulnerable because of race, ethnicity, gender, disability, age or social class. It is important for physicians who will be caring for an increasingly diverse nation to understand the lasting implications of this study for their patients, but the effects of the Tuskegee Syphilis Study are demonstrated most strikingly by unsuccessful attempts at improving representation of minority patients in clinical trials. PMID:9892266

  15. Ultrasonic inspection methodology

    International Nuclear Information System (INIS)

    Steam generator tubes are known to be susceptible to stress corrosion cracking (SCC). Primary water SCC (PWSCC) and more recently secondary water SCC (SWSCC) have been observed in some Belgian plants. To help dealing with these problems, Laborelec developed an ultrasonic (UT) inspection system. It has been used for the last two years on a sampling basis in several plants. The field and laboratory measurements confirmed the advantage of using UT for the early detection of small circumferential cracks while an excellent correlation was demonstrated between eddy current RPC and UT for axial PWSCC. In conclusion: The latest in-service inspections demonstrated an average measurement cycle of 50 to 60 seconds per tube including the manipulator displacement from tube to tube. A sample of about 250 tubes with axial cracks was measured on-site with the eddy current RPC technique and the new UT system. All the UT measured lengths were within ± 1.5 mm of the RPC results. The same results were obtained from the inspection of the tubes repaired with the nickel process (Doel 3). Some indications of circumferential secondary side stress corrosion cracking were recently observed. A comparison with the eddy current rotating pancake coil confirmed the improved detectability of the UT system. The field and laboratory results obtained with this UT inspection system demonstrated the advantage of applying the ultrasonic technique for the detection and sizing of small volume cracks like SCC. Also, the small focal spot of the UT beam provided a clear advantage for the detection of circumferential PWSCC in the presence of multiple axial cracks. With an average rate dose to 60 tubes per hour for the top of the tubesheet area, this UT system can be considered as an industrial tool for the inspection of steam generator tubes

  16. Big Lake Dam Inspection Report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes an inspection of the Big Lake Dam that was done in September of 1983. The inspection did not reveal any conditions that constitute and...

  17. Visual inspection of vessel internals

    International Nuclear Information System (INIS)

    Visual inspection has matured to a qualified testing method and has become a standard method for inspection of reactor pressure vessels. Until today, all known defects in RPV internals have been detected by visual inspection. The codes KTA 3204 and DIN 25435-4 describe the framework conditions and requirements for visual inspections, which should be adhered to to the most possible extent. Visual inspections are carried by now at all RPV internals, also at those where access is difficult and limited. The inspection robot SUSI is applied in most cases. The camera and manipulator technology meanwhile has been upgraded to a standard performance quality allowing reliable, fast and easy visual inspection. The personnel is trained accordingly, so as to keep abreast with enhancements. Qualification of the inspection system has been simplified and standardised to a large extent. (orig/CB)

  18. Unsuspected (clinically silent) multiple sclerosis. Quantitative investigations in one autoptic case.

    Science.gov (United States)

    Heinsen, H; Lockemann, U; Püschel, K

    1995-01-01

    The incidental retrieval of a few, well-circumscribed, chronic multiple sclerosis plaques in a 49-year-old female who died from myocardial infarct is reported. In serial gallocyanin stained frontal sections of the brain one plaque in the left and four plaques in the right hemisphere were encountered. A total of 1.25 cm3 or 0.24% of the right hemispheric volume and a total of 0.93 cm3 or 0.2% of the left hemispheric volume was afflicted. The size as well as the topography of the plaques could explain the absence of clinical symptoms. Methodological issues concerning in vivo and post mortem diagnosis of multiple sclerosis and their impact on the epidemiology of this disease are discussed. PMID:7632604

  19. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients

    DEFF Research Database (Denmark)

    Schulman, S; Angerås, U; Bergqvist, D;

    2010-01-01

    The definition of major bleeding varies between studies on surgical patients, particularly regarding the criteria for surgical wound-related bleeding. This diversity contributes to the difficulties in comparing data between trials. The Scientific and Standardization Committee (SSC), through its...... subcommittee on Control of Anticoagulation, of the International Society on Thrombosis and Haemostasis has previously published a recommendation for a harmonized definition of major bleeding in non-surgical studies. That definition has been adopted by the European Medicines Agency and is currently used in...... several non-surgical trials. A preliminary proposal for a parallel definition for surgical studies was presented at the 54(th) Annual Meeting of the SSC in Vienna, July 2008. Based on those discussions and further consultations with European and North American surgeons with experience from clinical trials...

  20. Development and internal structure investigation of the Dimensional Clinical Personality Inventory

    Directory of Open Access Journals (Sweden)

    Lucas de Francisco Carvalho

    2015-06-01

    Full Text Available This study aimed to develop a dimensional instrument to assess personality disorders based on Millon's theoretical perspective and on DSM-IV-TR diagnoses criteria, and seek validity evidence based on internal structure and reliability indexes of the factors. In order to do that, a self-report test composed of 215 items, the Dimensional Clinical Personality Inventory (DCPI was developed and applied to 561 respondents aged between 18 and 90 years (M = 28,8; SD = 11.4, with 51.8% females. Exploratory factor analysis and verification of reliability were performed using Cronbach's alpha. Data provided validity evidence based on internal structure of the instrument according to the theory of Millon and DSM-IV-TR.

  1. Photodynamic therapy for malignant and non-malignant diseases: clinical investigation and application

    Institute of Scientific and Technical Information of China (English)

    QIANG Yong-gang; ZHANG Xiu-ping; LI Jian; HUANG Zheng

    2006-01-01

    @@ Photodynamic therapy (PDT) is a relatively new treatment modality. Clinical PDT procedure involves the administration of a photosensitizer followed by local illumination with visible light of a specific wavelength. In the presence of molecule oxygen, the light illumination of photosensitizer can lead to a series of photochemical reactions and consequently generate a variety of cytotoxic species.The nature, location and quantity of PDT-induced cytotoxic species and the sensitivity of the target cells determine the outcome of a PDT treatment.Since the first government approval of photosensitizer Photofrin was granted, for the treatment of bladder cancer in Canada in 1993,1 the utilization of PDT in the treatment of malignant and non-malignant diseases has increased significantly due to the improvement in photosensitizers and light applicators. Several similar photosensitizers have been developed and utilization in China since the 1980s.2

  2. The Effects of Sex Steroids on Spatial Performance: A Review and an Experimental Clinical Investigation.

    Science.gov (United States)

    Liben, Lynn S.; Susman, Elizabeth J.; Finkelstein, Jordan W.; Chinchilli, Vernon M.; Kunselman, Susan; Schwab, Jacqueline; Dubas, Judith Semon; Demers, Laurence M.; Lookingbill, Georgia; D'Arcangelo, M. Rose; Krogh, Holleen R.; Kulin, Howard E.

    2002-01-01

    Investigated the relationship between sex hormones and spatial performance among adolescents treated with sex steroids for delayed puberty. Found that spatial performance varied according to gender but did not vary with levels of actively circulating sex steroids. Reviewed physiological mechanisms, developmental periods, and past empirical work…

  3. Assessing the Effectiveness of Parent-Child Interaction Therapy with Language Delayed Children: A Clinical Investigation

    Science.gov (United States)

    Falkus, Gila; Tilley, Ciara; Thomas, Catherine; Hockey, Hannah; Kennedy, Anna; Arnold, Tina; Thorburn, Blair; Jones, Katie; Patel, Bhavika; Pimenta, Claire; Shah, Rena; Tweedie, Fiona; O'Brien, Felicity; Leahy, Ruth; Pring, Tim

    2016-01-01

    Parent-child interaction therapy (PCIT) is widely used by speech and language therapists to improve the interactions between children with delayed language development and their parents/carers. Despite favourable reports of the therapy from clinicians, little evidence of its effectiveness is available. We investigated the effects of PCIT as…

  4. Optical inspection of NGL masks

    Science.gov (United States)

    Pettibone, Donald W.; Stokowski, Stanley E.

    2004-12-01

    For the last five years KLA-Tencor and our joint venture partners have pursued a research program studying the ability of optical inspection tools to meet the inspection needs of possible NGL lithographies. The NGL technologies that we have studied include SCALPEL, PREVAIL, EUV lithography, and Step and Flash Imprint Lithography. We will discuss the sensitivity of the inspection tools and mask design factors that affect tool sensitivity. Most of the work has been directed towards EUV mask inspection and how to optimize the mask to facilitate inspection. Our partners have succeeded in making high contrast EUV masks ranging in contrast from 70% to 98%. Die to die and die to database inspection of EUV masks have been achieved with a sensitivity that is comparable to what can be achieved with conventional photomasks, approximately 80nm defect sensitivity. We have inspected SCALPEL masks successfully. We have found a limitation of optical inspection when applied to PREVAIL stencil masks. We have run inspections on SFIL masks in die to die, reflected light, in an effort to provide feedback to improve the masks. We have used a UV inspection system to inspect both unpatterned EUV substrates (no coatings) and blanks (with EUV multilayer coatings). These inspection results have proven useful in driving down the substrate and blank defect levels.

  5. Inspecting fuel pellets for nuclear reactor

    International Nuclear Information System (INIS)

    An improved method of controlling the inspection, sorting and classifying of nuclear reactor fuel pellets, including a mechanical handling system and a computer controlled data processing system, is described. Having investigated the diameter, length, surface flaws and weights of the pellets, they are sorted accordingly and the relevant data are stored. (U.K.)

  6. From Inspection to School Improvement? Evaluating the Accelerated Inspection Programme in Waltham Forest.

    Science.gov (United States)

    Hopkins, David; Harris, Alma; Watling, Rob; Beresford, John

    1999-01-01

    Outlines the main findings from the evaluation of the Accelerated Inspection Programme (AIP) in Waltham Forest under three main phases (pre-inspection, inspection, and post inspection). Focuses on the relationship between inspection and school improvement. Discusses the recommendations. (CMK)

  7. The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations.

    Science.gov (United States)

    Kohen Avramoglu, Rita; Laplante, Marc-André; Le Quang, Khai; Deshaies, Yves; Després, Jean-Pierre; Larose, Eric; Mathieu, Patrick; Poirier, Paul; Pérusse, Louis; Vohl, Marie-Claude; Sweeney, Gary; Ylä-Herttuala, Seppo; Laakso, Markku; Uusitupa, Matti; Marette, André

    2013-10-01

    Cardiovascular complications (CVC) are the most common causes of death in patients with type 2 diabetes (T2D). However the pathophysiological determinants and molecular mechanisms involved in the progression of CVC in T2D are poorly understood. We have undertaken the challenging task of identifying some of the genetic and clinical determinants of CVC through a unique multidisciplinary approach involving Canadian and Finnish investigators. We are studying novel animal models combining atherosclerosis, diet-induced obesity and T2D to understand the molecular basis of CVC in obesity-linked T2D. We are also conducting clinical studies to identify key determinants of CVC in T2D patients and to determine whether a lifestyle modification program targeting loss of visceral adipose tissue/ectopic fat could be associated with clinical benefits in these patients. Together, we strongly believe that we can fill some gaps in our understanding of the CVC pathogenesis in T2D and identify novel therapeutic targets and hope that this new knowledge may be translated into the design of effective clinical interventions to optimally reduce cardiovascular risk in T2D subjects. PMID:24500564

  8. Simulating an investigative study of clinical cancer samples: use of tissue slides and PCR-based promoter-hypermethylation analysis.

    Science.gov (United States)

    Chew, Yuan Yuan; Chin, Cheen Fei; Yeong, Foong May

    2015-01-01

    Topics on the molecular basis underlying cancer are quite popular among students. Also, excellent textbooks abound that provide interesting materials for discussion during lectures and tutorials about major events leading to cancer formation and progression. However, much less is available for students to conduct experiments for the analysis of cancer samples in undergraduate modules where there is a limited time-frame. Given the difficulty of working with cancer samples and the scarcity of good samples even in the clinical laboratories, it is impossible to run large-class practicals using patients' samples. Here, we describe the use of tissue slides in combination with polymerase-chain reaction (PCR) as a means of simulating an investigative approach to supplement students' learning of clinical research. By using tissue slides for histo-pathological examinations and specific budding yeast genomic DNA and primers adapted to demonstrate methylation-specific PCR, we designed an inquiry-based lab session to simulate the clinical investigation of a cohort of biopsies that students could analyze in a one-session practical. PMID:25395208

  9. Evaluating clinical trial designs for investigational treatments of Ebola virus disease.

    Directory of Open Access Journals (Sweden)

    Ben S Cooper

    2015-04-01

    Full Text Available Experimental treatments for Ebola virus disease (EVD might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic.A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA with two or three stages, including both non-randomised and randomised elements. The probabilities of rightly or wrongly recommending the experimental treatment, the required sample size, and the consequences for epidemic outcomes over 100 d under two epidemic scenarios were compared for the MSA, a sequential randomised controlled trial (SRCT with up to 20 interim analyses, and, as a reference case, a conventional randomised controlled trial (RCT without interim analyses. Assuming 50% 14-d survival in the population treated with the current standard of supportive care, all designs had similar probabilities of identifying effective treatments correctly, while the MSA was less likely to recommend treatments that were ineffective. The MSA led to a smaller number of cases receiving ineffective treatments and faster roll-out of highly effective treatments. For less effective treatments, the MSA had a high probability of including an RCT component, leading to a somewhat longer time to roll-out or rejection. Assuming 100 new EVD cases per day, the MSA led to between 6% and 15% greater reductions in epidemic mortality over the first 100 d for highly effective treatments compared to the SRCT. Both the MSA and SRCT led to substantially fewer deaths than a conventional RCT if the tested interventions were either highly effective or harmful. In the proposed MSA, the major threat to the validity of the results of the non-randomised components is that referral patterns, standard of care, or the virus itself may change during the study period in ways that affect mortality

  10. Inflammatory bowel disease in children--clinical, endoscopic, radiologic and histopathologic investigation.

    Science.gov (United States)

    Seo, J K; Yeon, K M; Chi, J G

    1992-09-01

    This paper reviews our five years' clinical experience (1987 to 1991) of 22 patients with inflammatory bowel disease (IBD). There were 12 patients with Crohn's disease and 10 patients with ulcerative colitis. The mean age at diagnosis was 8.7 years (2 to 14 years). Clinical impressions before referral were chronic diarrhea in 11, irritable bowel syndrome in 5, colon polyp in 4, lymphoma in 3, intestinal tuberculosis in 2, amoebic colitis in 2, ulcerative colitis in 2 children and other diseases. The mean interval from the onset of symptoms to the diagnosis of IBD was 18 months. Diagnosis of Crohn's disease was delayed for more than 13 months in 8 (67%), whereas that of ulcerative colitis was delayed for more than 13 months in 4 (40%). Diarrhea (50%), abdominal pain (36%) and rectal bleeding (36%) were the three most frequent presenting complaints of IBD. Moderately severe abdominal pain was a more common chief complaint in Crohn's disease (58%) than in ulcerative colitis (10%). Hematochezia (90% vs 17%) and moderately severe diarrhea (90% vs 75%) were more common gastrointestinal manifestations in ulcerative colitis than in Crohn's disease. The associated extraintestinal manifestations were oral ulcer in 7, arthralgia in 11 and arthritis in 4, skin lesions in 2, eye lesions in 2 and growth failure in 9 patients. Of 12 children with Crohn's disease, granuloma was found in 5, aphthous ulcerations in 8, cobble stone appearance in 8, skip area or asymmetric lesions in 6, transmural involvement in 7, and perianal fistula in 3. Among 10 children with ulcerative Colitis, there were crypt abscess in 8, granularity or friability in 10 and rectosigmoid ulcerations with purulent exudate in 8 children. The main sites of involvement in children with Crohn's disease were both the small and large bowels in 7 (58%), small bowel only in 2 (16%), and colon only in 3 (25%). Terminal ileum involvement was seen in 75% of Crohn's disease cases. The main sites of involvement in children

  11. Investigation of correlation between colonic cancer related anemia and characteristics of clinical pathology

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Objective To investigate the correlation between colonic cancer-related anemia and the pathologic features of colonic cancer.Methods The relationship between colonic cancer-related anemia and the pathologic features of colonic cancer was analyzed in a statistical method.Results There was no statistical significance between the histopathological type and incidence of colonic cancer-related anemia(P>0.05).There was statistical significance between the general classification of colonic cancer

  12. Clinical investigation of the effect of topical anesthesia on intraocular pressure

    OpenAIRE

    Almubrad, Turki M.; Kelechi C. Ogbuehi

    2007-01-01

    Background/Aims: Contact tonometry is generally considered more accurate than non-contact tonometry in the assessment of intraocular pressure (IOP). This study was designed to investigate the effect of ocular anesthesia, a pre-requisite for contact tonometry, on the IOP in a sample of visually normal subjects. Method: In a random sample of 120 young visually normal subjects (divided equally among three groups), the Topcon CT80 non-contact tonometer was used to measure IOP before, at the secon...

  13. Effect of Low-Level Laser Therapy on Orthodontic Tooth Movement: A Clinical Investigation

    OpenAIRE

    Dalaie, Kazem; Hamedi, Roya; Kharazifard, Mohammad Javad; Mahdian, Mina; Bayat, Mehrdad

    2015-01-01

    Objectives: One major drawback of orthodontic treatment is its long duration due to slow tooth movement and the pain at the onset of treatment following application of forces. There is controversy regarding the efficacy of laser for decreasing the treatment time and pain of orthodontic treatment. The purpose of this study was to investigate the effect of low level diode laser on the rate of orthodontic tooth movement and the associated pain. Materials and Methods: In this double blind randomi...

  14. Overview of the software inspection process

    Energy Technology Data Exchange (ETDEWEB)

    Lane, G.L.; Dabbs, R. [Sandia National Labs., Albuquerque, NM (United States)

    1997-11-01

    This tutorial introduces attendees to the Inspection Process and teaches them how to organize and participate in a software inspection. The tutorial advocates the benefits of inspections and encourages attendees to socialize the inspection process in their organizations.

  15. Clinical investigation of flat panel CT following middle ear reconstruction: a study of 107 patients

    International Nuclear Information System (INIS)

    After middle ear reconstruction using partial or total ossicular replacement prostheses (PORP/TORP), an air-bone gap (ABG) may persist because of prosthesis displacement or malposition. So far, CT of the temporal bone has played the main role in the diagnosis of reasons for postoperative insufficient ABG improvement. Recent experimental and clinical studies have evaluated flat panel CT (fpCT) as an alternative imaging technique that provides images with high isovolumetric resolution, fewer metal-induced artefacts and lower irradiation doses. One hundred and seven consecutive patients with chronic otitis media with or without cholesteatoma underwent reconstruction by PORP (n = 52) or TORP (n = 55). All subjects underwent preoperative and postoperative audiometric testing and postoperative fpCT. Statistical evaluation of all 107 patients as well as the sole sub-assembly groups (PORP or TORP) showed a highly significant correlation between hearing improvement and fpCT-determined prosthesis position. FpCT enables detailed postoperative information on patients with middle ear reconstruction. FpCT is a new imaging technique that provides immediate feedback on surgical results after reconstructive middle ear surgery. Specific parameters evaluated by fpCT may serve as a predictive tool for estimated postoperative hearing improvement. Therefore this imaging technique is suitable for postoperative quality control in reconstructive middle ear surgery. (orig.)

  16. The first Korean case of HDR syndrome confirmed by clinical and molecular investigation.

    Science.gov (United States)

    Cheon, Chong Kun; Kim, Gu Hwan; Yoo, Han Wook

    2015-01-01

    Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is a rare condition inherited as autosomal dominant trait and characterized by hypoparathyroidism, sensorineural deafness, and renal dysplasia. HDR syndrome is caused by haploinsufficiency of the GATA3 gene located on chromosome 10p15. Here, we report the case of a 32-day-old Korean male with HDR syndrome. He was presented due to repeated seizures over previous 3 days. The patient was born after 40 weeks of gestation with birth weight of 2930 g, and was the first-born baby of healthy Korean parents. Hypoparathyroidism was first noticed due to seizure. A multicystic left dysplastic kidney and vesicoureteral reflux were detected by ultrasound after birth. Auditory brainstem response (ABR) testing revealed that the patient had moderate sensorineural deafness, with hearing losses of 80 dB at the mid and higher frequencies for both ears. Echocardiography finding revealed secundum atrial septal deftect. Based on biochemical results and clinical findings, a presumptive diagnosis of HDR syndrome was made. GATA3 mutation analysis identified a heterozygous deletion, c.153del (p.Phe51Leufs*144) in exon 1 causing a frameshift mutation, which is a novel de novo mutation. Therefore, we suggest that HDR syndrome should be considered in the differential diagnosis in symptomatic or asymptomatic patients with hypoparathyroidism, and that renal ultrasound or ABR testing be performed to prevent a missed diagnosis. This is the first report on Korean patient with confirmed HDR syndrome with novel mutation. PMID:25510779

  17. Clinical and X-ray investigations on congenital radio-ulnar synostosis

    International Nuclear Information System (INIS)

    Out of 13 patients with cogenital radio-ulnar synostosis, 10 could be subjected to clinical and X-ray examination and chromosome analysis. In all the family histories the radio-ulnar synostosis was an isolated event. In no case was definite heredity of the same malformation confirmed. In most cases the radio-ulnar synostosis was an isolated malformation. 7 patients were of female, 6 of male sex. In 5 cases the synostosis was bi-lateral, in 8 cases it was unilateral without preference of either side of the body. In 2 out of 10 patients subjected to chromosome analysis gonosomal aneuploidy was found. More often than hitherto supposed, radio-ulnar synostosis seems to be associated with lower forms of polysomia of the x-chromosomes. 15 out of 18 synostoses belonged to type II, 3 to type I. The different types represent merely differring degrees of manifestation of the same deformity occurring bilaterally in one person. All patients with radio-ulnar synostosis exhibited a high degree of functional tolerance to the malformation. The development in child age and the educational and professional record were hardly impaired. (orig./MG)

  18. Clinical Assessment and Management of Spondyloarthritides in the Middle East: A Multinational Investigation

    Science.gov (United States)

    Hammoudeh, Mohammed; Al Rayes, Hanan; Gado, Kamel; Shirazy, Khalid; Deodhar, Atul

    2015-01-01

    Data on spondyloarthritis (SpA) from the Middle East are sparse and the management of these diseases in this area of the world faces a number of challenges, including the relevant resources to enable early diagnosis and referral and sufficient funds to aid the most appropriate treatment strategy. The objective was to report on the characteristics, disease burden, and treatment of SpA in the Middle East region and to highlight where management strategies could be improved, with the overall aim of achieving better patient outcomes. This multicenter, observational, cross-sectional study collected demographic, clinical, laboratory, and treatment data on 169 consecutive SpA patients at four centers (Egypt, Kuwait, Qatar, and Saudi Arabia). The data collected presents the average time from symptom onset to diagnosis along with the presence of comorbidities in the region and comparisons between treatment with NSAIDs and biologics. In the absence of regional registries of SpA patients, the data presented here provide a rare snapshot of the characteristics, disease burden, and treatment of these patients, highlighting the management challenges in the region. PMID:26793241

  19. Clinical investigation of flat panel CT following middle ear reconstruction: a study of 107 patients

    Energy Technology Data Exchange (ETDEWEB)

    Zaoui, K. [University Hospital Heidelberg, Ruprecht Karls University, Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg (Germany); Kromeier, J. [St. Josefs Hospital, RkK, Department of Radiology, Freiburg (Germany); Neudert, M.; Beleites, T.; Zahnert, T. [University Hospital Dresden, Technical University, Department of Otorhinolaryngology, Head and Neck Surgery, Dresden (Germany); Laszig, R.; Offergeld, C. [University Hospital Freiburg, Albert Ludwigs University, Department of Otorhinolaryngology, Head and Neck Surgery, Freiburg (Germany)

    2014-03-15

    After middle ear reconstruction using partial or total ossicular replacement prostheses (PORP/TORP), an air-bone gap (ABG) may persist because of prosthesis displacement or malposition. So far, CT of the temporal bone has played the main role in the diagnosis of reasons for postoperative insufficient ABG improvement. Recent experimental and clinical studies have evaluated flat panel CT (fpCT) as an alternative imaging technique that provides images with high isovolumetric resolution, fewer metal-induced artefacts and lower irradiation doses. One hundred and seven consecutive patients with chronic otitis media with or without cholesteatoma underwent reconstruction by PORP (n = 52) or TORP (n = 55). All subjects underwent preoperative and postoperative audiometric testing and postoperative fpCT. Statistical evaluation of all 107 patients as well as the sole sub-assembly groups (PORP or TORP) showed a highly significant correlation between hearing improvement and fpCT-determined prosthesis position. FpCT enables detailed postoperative information on patients with middle ear reconstruction. FpCT is a new imaging technique that provides immediate feedback on surgical results after reconstructive middle ear surgery. Specific parameters evaluated by fpCT may serve as a predictive tool for estimated postoperative hearing improvement. Therefore this imaging technique is suitable for postoperative quality control in reconstructive middle ear surgery. (orig.)

  20. Computed tomographic, electrocardiographic and clinical investigations in patients with ischemic strokes

    International Nuclear Information System (INIS)

    The Computed Tomography (CT) is a widely available and reliable method for the diagnosis of cerebrovascular disease. It allows in the first hours of the occurrence of vascular events to be established the type of brain stroke and creates conditions for timely fibrinolytic or surgical treatment. In many cases where it cannot be performed echocardiographic examination modern electrocardiography (ECG) makes it possible to demonstrate the presence of cardiac disease. These two methods in combination with neurological status create conditions for determining the treatment strategy for ischemic brain stroke (IBS). We studied 222 patients (92 men and 110 women with a middle age 59.7 years) selected randomized. At a computed tomography study in the early hours of IBS were found pathological findings in 115 patients (51.8%) slightly more often in women. IBS in the carotid system were greatly predominant in comparison with those in the vertebrobasilar system (VBS), which can be explained with the blood flow to the brain stem. When ECG is most commonly met diagnosis: hypertension HSSN 111 stage II - III functional class NYUHA, ischemic cardiomyopathy in 64 patients overall, with almost equal frequency in men 30 (17.5%) and women - 34 (19.8%). In neurological examination significantly predominant clinical symptoms karoditnata vasculature, in 154 patients (69.3%) compared to that of the VBS- 68 (30.7%). Fulfilled study shows the need for better coordination of the activities of specialists in diagnostic imaging and neurologists for their work in specialized hospitals (Stroke Units). (authors)

  1. Clinical Assessment and Management of Spondyloarthritides in the Middle East: A Multinational Investigation

    Directory of Open Access Journals (Sweden)

    Mohammed Hammoudeh

    2015-01-01

    Full Text Available Data on spondyloarthritis (SpA from the Middle East are sparse and the management of these diseases in this area of the world faces a number of challenges, including the relevant resources to enable early diagnosis and referral and sufficient funds to aid the most appropriate treatment strategy. The objective was to report on the characteristics, disease burden, and treatment of SpA in the Middle East region and to highlight where management strategies could be improved, with the overall aim of achieving better patient outcomes. This multicenter, observational, cross-sectional study collected demographic, clinical, laboratory, and treatment data on 169 consecutive SpA patients at four centers (Egypt, Kuwait, Qatar, and Saudi Arabia. The data collected presents the average time from symptom onset to diagnosis along with the presence of comorbidities in the region and comparisons between treatment with NSAIDs and biologics. In the absence of regional registries of SpA patients, the data presented here provide a rare snapshot of the characteristics, disease burden, and treatment of these patients, highlighting the management challenges in the region.

  2. Inspections Report 2002 - 2003; Tillsynsrapport 2002 - 2003

    Energy Technology Data Exchange (ETDEWEB)

    Viidas, Josefin

    2004-10-01

    The report summarises primarily the supervision of waste management and environmental protection at the nuclear facilities that was carried out by the Swedish Radiation Protection Authority in 2002 and 2003. A summary of the inspections and a description of important issues connected with the supervision of nuclear facilities are given. The inspections during 2002 focused on the investigation and coverage of the mishap related to the transport of iridium from Studsvik. The Studsvik project was initiated and the remaining supervision was temporarily given lower priority. In 2003 SSI performed two theme inspections. One focused on the handling of waste management and the other on the limitation of the effluent. Extensive supervision efforts concentrated also on Ranstad Mineral inc.

  3. Thermal inspection of composite honeycomb structures

    Science.gov (United States)

    Zalameda, Joseph N.; Parker, F. Raymond

    2014-05-01

    Composite honeycomb structures continue to be widely used in aerospace applications due to their low weight and high strength advantages. Developing nondestructive evaluation (NDE) inspection methods are essential for their safe performance. Pulsed thermography is a commonly used technique for composite honeycomb structure inspections due to its large area and rapid inspection capability. Pulsed thermography is shown to be sensitive for detection of face sheet impact damage and face sheet to core disbond. Data processing techniques, using principal component analysis to improve the defect contrast, are presented. In addition, limitations to the thermal detection of the core are investigated. Other NDE techniques, such as computed tomography X-ray and ultrasound, are used for comparison to the thermography results.

  4. Thermal Inspection of Composite Honeycomb Structures

    Science.gov (United States)

    Zalameda, Joseph N.; Parker, F. Raymond

    2014-01-01

    Composite honeycomb structures continue to be widely used in aerospace applications due to their low weight and high strength advantages. Developing nondestructive evaluation (NDE) inspection methods are essential for their safe performance. Pulsed thermography is a commonly used technique for composite honeycomb structure inspections due to its large area and rapid inspection capability. Pulsed thermography is shown to be sensitive for detection of face sheet impact damage and face sheet to core disbond. Data processing techniques, using principal component analysis to improve the defect contrast, are presented. In addition, limitations to the thermal detection of the core are investigated. Other NDE techniques, such as computed tomography X-ray and ultrasound, are used for comparison to the thermography results.

  5. Eddy current inspection methodology

    International Nuclear Information System (INIS)

    World-wide operating experience with nuclear pressurized water reactors shows that most steam generators show evidence of major degradation phenomena. Laborelec has designed several automated inspection systems using eddy current (bobbin coil, pancake coils and rotating coil) and ultrasound techniques. The bobbin coil is mostly used as a fast and global detection method while dedicated sensors, like the rotating pancake coil, are applied for an improved defect characterization. Experience has demonstrated that significant advantages in accuracy, reliability and cost are intimately related to the automation process. In conclusion: The concept of a multipurpose inspection system satisfies the safety goal and the utility requirements for reliability, accuracy and lower costs. An optimum was reached by equipment modularity, computer control and integrated design of sensors and instrumentation. What previously required several man-weeks of work is now achieved within a few hours time. With a presently unparalleled field performance, Laborelec has set the basis of new industrial standards

  6. Clinical course of cor pulmonale investigated after an interval of one year by thallium-201 myocardial SPECT scintigraphy

    International Nuclear Information System (INIS)

    Cor pulmonale was evaluated in 13 patients with chronic lung disease by thallium-201 myocardial SPECT scintigraphy together with pulmonary function tests and right heart catheterization. One year later, we performed this scintigraphy again to investigate the clinical course of the cor pulmonale. In 6 of 13 patients with respiratory failure (Pao2 less than 60 Torr), a remarkable progression in cor pulmonale was noted after one year, despite outpatient oxygen therapy. If the patients were admitted because of acute exacerbation of respiratory failure, the cor pulmonale was found to have worsened. In contrast, patients with acute exacerbation due to respiratory infection or causes other than respiratory failure, showed little change in cor pulmonale. Although patients with a marked progression of cor pulmonale tended to have poor pulmonary function data and elevated pulmonary arterial pressure, the clinical course of cor pulmonale could not be predicted from the initial pulmonary function tests or right heart catheterization. (author)

  7. [On the antipyretic effect of paracetamol. Clinical investigation with two different forms of application (author's transl)].

    Science.gov (United States)

    Götte, R; Liedtke, R

    1978-01-01

    144 children, aged between 15 days and 12 years, suffering from febrile condition of various etiology, were treated with differentiated single doses of paracetamol (N-acetyl-p-aminophenol) in form of syrup, suppositories and a combination of syrup with the antihistamine doxylaminsuccinate. During investigation periods of four hours, applying reduced doses, the syrup application showed the same antipyretic effects as those obtained with paracetamol suppositories. When administering the combination with doxylaminsuccinate, the antipyretic effect was reduced and the psychomotoric superactivity did not improve. A control of the actual rectal dosage scheme for repetitive applications is recommended and the combination of paracetamol with sedatives is to be discussed. PMID:304522

  8. Explorative investigation of biomarkers of brain damage and coagulation system activation in clinical stroke differentiation

    DEFF Research Database (Denmark)

    Undén, Johan; Strandberg, Karin; Malm, Jan;

    2009-01-01

    INTRODUCTION: A simple and accurate method of differentiating ischemic stroke and intracerebral hemorrhage (ICH) is potentially useful to facilitate acute therapeutic management. Blood measurements of biomarkers of brain damage and activation of the coagulation system may potentially serve as novel...... diagnostic tools for stroke subtypes. METHODS: Ninety-seven stroke patients were prospectively investigated in a multicenter design with blood levels of brain biomarkers S100B, neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP) as well as a coagulation biomarker, activated protein C...... exploratory study indicated that blood levels of biomarkers GFAP and APC-PCI, prior to neuroimaging, may rule out ICH in a mixed stroke population....

  9. Clinical investigation on usefulness of MRI in the diagnosis of mediastinal masses

    Energy Technology Data Exchange (ETDEWEB)

    Oyama, Takao (Kagoshima Univ. (Japan). Faculty of Medicine)

    1994-02-01

    This study evaluated the utility of magnetic resonance imaging (MRI) in diagnosing mediastinal masses. The subjects were 96 patients with pathologically (n=82) and clinically (n=14) proven mediastinal masses, consisting of thymomas (30), teratomas (4), other thymic tumors (5), intrathoracic goiters (4), neurogenic tumors (7), congenital cysts (12), mesenchymal tumors (10), vascular masses (5), phrenic hernia (3), malignant lymphomas (6), and sarcoidosis (10). MRI findings, including marginal and capsular appearances, internal structures and signal intensities, were analyzed. Internal structure characteristic to thymomas were seen in 24 teratoma patients (80%). In 4 teratomas, MRI was capable of distinguishing benign (2) from malignant (2) ones. In the other 5 thymic tumors, MRI delineated chemical characteristics of fluids for thymic cysts (2) and internal structures for thymic cancer (2) and lipoma (one). It also delineated the continuity of intrathoracic goiter from the cervical to intrathoracic regions. For neurogenic tumors, MRI was capable of distinguishing neurofibromas from schwannomas and also benign from malignant schwannomas. A well-defined smooth margin and very high signal intensity, which were characteristic to congenital cysts, were seen on T2-weighted images. Signal intensities on T1-weighted images reflected fluid features in cysts. For mesenchymal tumors, consisting of hemangioma, hemangiosarcoma, malignant melanoma, aneurysmal bone cyst and osteosarcoma, lymphangioma and chondrosarcoma, all but osteosarcoma showed their respective characteristic MRI findings. Vascular masses were delineated as flow void structures. MRI delineated herniated contents. Malignant lymphoma was shown as irregular and inhomogeneous swollen lymph nodes, but sarcoidosis was shown as regular and homogeneous ones on MRI. In conclusion, MRI is a useful, informative modality for diagnosing mediastinal masses. (N.K.) 84 refs.

  10. Pressurized water reactor inspection procedures

    International Nuclear Information System (INIS)

    Inspections of the reactor pressure vessels of pressurized water reactors (PWR) so far used to be carried out with different central mast manipulators. For technical reasons, parallel inspections of two manipulators alongside work on the refueling cavity, so as to reduce the time spent on the critical path in a revision outage, are not possible. Efforts made to minimize the inspection time required with one manipulator have been successful, but their effects are limited. Major reductions in inspection time can be achieved only if inspections are run with two manipulators in parallel. The decentralized manipulator built by GEC Alsthom Energie and so far emmployed in boiling water reactors in the USA, Spain, Switzerland and Japan allows two systems to be used in parallel, thus reducing the time required for standard inspection of a pressure vessel from some six days to three days. These savings of approximately three days are made possible without any compromises in terms of positioning by rail-bound systems. During inspection, the reactor refueling cavity is available for other revision work without any restrictions. The manipulator can be used equally well for inspecting standard PWR, PWR with a thermal shield, for inspecting the land between in-core instrumentation nozzles, BWR with and without jet pumps (complementary inspection), and for inspecting core support shrouds. (orig.)

  11. NRU light water reflector inspections

    Energy Technology Data Exchange (ETDEWEB)

    Lumsden, R.H.; Hebert, H.; Zahn, N.; Simpson, N.W. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)

    2011-07-01

    In 2009 May, the National Research Universal (NRU) calandria leaked. In the next year the calandria was inspected with six new techniques, repaired, and the repair inspected with four additional new techniques. The calandria is surrounded by a light water reflector vessel. Concerns that the same corrosion mechanism may have damaged the reflector vessel led to plans to inspect the full circumference of the reflector wall for corrosion damage, through a 64 mm diameter port, from 10 m away, while inspecting from the corroded surface. The ultrasonic technique is intended to produce a very fine inspection grid, through the corroded surface, using a very small probe body over the approximately 5 m{sup 2} to be inspected. The calandria vessel inspections were successfully performed, in a short time period, under difficult conditions. This paper will discuss Operating Experience (OPEX) from the 2009/2010 calandria wall inspections and industry dialogue that were applied to the Reflector Wall Inspection (RWI) project. Interaction with the CANDU Inspection Qualification Bureau (CIQB) on procedures, training plans, and mock-up training, led to improvements in how these activities were performed for the RWI project. Experience with shift turnover meetings led to improvements in how the inspection team captures lessons learned, trends issues, and eliminates reoccurring design and procedure problems. Experience with collected and analyzed data, inspection shift logs, and video captured from inspections and repairs, were used to improve inspection performance. Finally, OPEX from radiation/activation and the calibration process reduced dose through tool design and procedure changes. (author)

  12. A study on improvements of inspection efficiency with remote transmission of inspection data

    International Nuclear Information System (INIS)

    Current information networks technology brought secure and convenient condition of information transmission, so that inspectorates intend to apply such technology to optimize current inspection efforts. IAEA established the Remote Monitoring Project (RMP) in 1996 and started to draft safeguards concepts, and approaches to refer the implementation of remote monitoring technology and to compromise with relationship between current inspection activities and the remote monitoring technologies. Although communications costs and conditions of secured communication should be further investigated, the technologies would have a possibility to reduce current inspection efforts. We would face at the step to study on the several issues such as what measures could be candidate to use, how much cost we needs, what kind of technical risks would be concerned, further improvements could be achieved by comparison with current inspection costs and effectiveness. This paper reports on the expectation points and relevant technical attention points which are related to apply unattended inspection system with remote data transmission to the flows and inventory verification of item and bulk facility, respectively, in order to improve inspection efforts. (author)

  13. Relationship between Histological and Clinical Course of Psoriasis: A Pilot Investigation by Reflectance Confocal Microscopy during Goeckerman Treatment.

    Science.gov (United States)

    Archid, Rami; Duerr, Hans Peter; Patzelt, Alexa; Philipp, Sandra; Röwert-Huber, Hans-Joachim; Ulrich, Martina; Meinke, Martina Claudia; Knorr, Fanny; Lademann, Jürgen

    2016-01-01

    Alterations of the skin microvasculature are known to play an important role in the development and maintenance of psoriatic skin lesions. In this study, we investigated lesional skin in 11 psoriatic patients during a modified Goeckerman treatment using reflectance confocal microscopy (RCM) to study the relationship between clinical clearance and histological normalization of psoriatic skin and the significance of histological abnormalities on the course of disease. The treatment regimen resulted in a significant reduction of the Psoriasis Area and Severity Index (PASI) as well as capillary and papillary diameters (p RCM findings as successor of the PASI in the monitoring of psoriasis. PMID:26841099

  14. Investigation of the use of thermography for research and clinical applications in pregnant women

    Science.gov (United States)

    Topalidou, Anastasia; Downe, Soo

    2016-03-01

    Background: The possibility of using thermal imaging, as a non-invasive method, in medicine may provide potential ability of advanced imaging. Objective: The conduction of a preliminary study in healthy non-pregnant females in order to investigate the imaging ability of thermography and its implementation; and to determine hot and cold areas in order to create a "map" of temperature distribution of the abdomen and the torso. Methods: Participants were 18-45 years old non-pregnant women (n = 10), who were measured at 4 different distances. Two thermal imaging cameras and their corresponding software were used to measure abdomen, low back, left and right side of the torso. Results: There were no statistically significant differences in the mean values of the exported temperatures according the distance and the angle between the camera and the subject. The inferior part of the rectus abdominis muscle recorded the coldest zone and the umbilicus appeared as the most prominent hot spot. Conclusions: Thermography shows to be a potential non-invasive technique offering new options in the evaluation of pregnant and laboring women.

  15. Clinic-like animal model for causal-pathogenetical investigations of hypoxic-ischemic brain injuries

    International Nuclear Information System (INIS)

    The complex nature of the pathogenesis in hypoxic-ischemic brain injuries equires the combined determination of the dynamics of main factors in these disturbing processes. The application of suitable methods for registration of such pathogenetic processes is shown in an adequate animal model for simulating the early hypoxic-ischemic brain injuries. That the radioactive labelled microsphere technique is suitable to comprehend quantitively the dynamics of the intracerebral redistribution of the circulating blood due to hypoxia/hypercapnia by simultaneous-multiple measuring of the regional cerebral blood flow. Therefore, at the first time an inadequate hypoxic-induced blood flow increase was shown in large parts of the forebrain in intrauterine growth retarded newborn piglets. For estimation of the regional cerebral glucose utilization in newborn piglets, the 18F-FDG Positron Emission Tomography is introduced. The measurements were carried out on a stationary high-density avalanche chamber (HIDAC) camera and yielded the fundamental application of this camera model for PET investigations also in the newborn brain due to the very good spatial resolution. (orig.)

  16. Innovative use of global navigation satellite systems for flight inspection

    Science.gov (United States)

    Kim, Eui-Ho

    The International Civil Aviation Organization (ICAO) mandates flight inspection in every country to provide safety during flight operations. Among many criteria of flight inspection, airborne inspection of Instrument Landing Systems (ILS) is very important because the ILS is the primary landing guidance system worldwide. During flight inspection of the ILS, accuracy in ILS landing guidance is checked by using a Flight Inspection System (FIS). Therefore, a flight inspection system must have high accuracy in its positioning capability to detect any deviation so that accurate guidance of the ILS can be maintained. Currently, there are two Automated Flight Inspection Systems (AFIS). One is called Inertial-based AFIS, and the other one is called Differential GPS-based (DGPS-based) AFIS. The Inertial-based AFIS enables efficient flight inspection procedures, but its drawback is high cost because it requires a navigation-grade Inertial Navigation System (INS). On the other hand, the DGPS-based AFIS has relatively low cost, but flight inspection procedures require landing and setting up a reference receiver. Most countries use either one of the systems based on their own preferences. There are around 1200 ILS in the U.S., and each ILS must be inspected every 6 to 9 months. Therefore, it is important to manage the airborne inspection of the ILS in a very efficient manner. For this reason, the Federal Aviation Administration (FAA) mainly uses the Inertial-based AFIS, which has better efficiency than the DGPS-based AFIS in spite of its high cost. Obviously, the FAA spends tremendous resources on flight inspection. This thesis investigates the value of GPS and the FAA's augmentation to GPS for civil aviation called the Wide Area Augmentation System (or WAAS) for flight inspection. Because standard GPS or WAAS position outputs cannot meet the required accuracy for flight inspection, in this thesis, various algorithms are developed to improve the positioning ability of Flight

  17. Investigating the effect of clinical governess approach on patients' length of stay in emergency department: an action research study.

    Directory of Open Access Journals (Sweden)

    Tahmine Salehi

    2014-02-01

    Full Text Available Over the past decade, clinical governance approach with aims to improve the quality of health services has been proposed in Iran. Considering the obvious problems especially patients' length of stay (LOS in the emergency departments (EDs; the present study has been carried out with the purpose of Investigating the effect of clinical governess approach on patients' LOS in the one of the largest medical centers in the country. After the problem was specified by the 17 interviews with employees and managers of the ED; the emergency clinical governance committee was formed by two academic researchers and seven ED staff (key participants that had the most involvement with the subject of study. The activities of the committee, including planning, acting, observing and reflecting, was organized by using participatory action research approach and action research cycle (Kemmis 1995. During this time, three formal meetings with key participants were held in 6-month intervals. Monthly records of patients' average LOS and interview with ED staff were used to analyze the findings. The research was completed with two cycles in one year. Committee members took the following actions. As a result, the patients' LOS reduced from 2.68 days to 1.73 days. Make regular patients visits by medical groups especially orthopedists and neurologists; Decision making about patients situation by emergency physicians and transferring patients to the relevant units by bed managers; Refusing to admit elective patients during overcrowding times; to regulate the list of patients requiring ICU by anesthesiologists. Prolonged LOS can be due to various causes and a team approach, which is one of the requirements of clinical governance approach, is needed to manage it. The results showed that the multidisciplinary team could make positive changes and reduce LOS in emergency setting.

  18. Investigation of the use of MOSFET for clinical IMRT dosimetric verification

    International Nuclear Information System (INIS)

    With advanced conformal radiotherapy using intensity modulated beams, it is important to have radiation dose verification measurements prior to treatment. Metal oxide semiconductor field effect transistors (MOSFET) have the advantage of a faster and simpler reading procedure compared to thermoluminescent dosimeters (TLD), and with the commercial MOSFET system, multiple detectors can be used simultaneously. In addition, the small size of the detector could be advantageous, especially for point dose measurements in small homogeneous dose regions. To evaluate the feasibility of MOSFET for routine IMRT dosimetry, a comprehensive set of experiments has been conducted, to investigate the stability, linearity, energy, and angular dependence. For a period of two weeks, under a standard measurement setup, the measured dose standard deviation using the MOSFETs was ±0.015 Gy with the mean dose being 1.00 Gy. For a measured dose range of 0.3 Gy to 4.2 Gy, the MOSFETs present a linear response, with a linearity coefficient of 0.998. Under a 10x10 cm2 square field, the dose variations measured by the MOSFETs for every 10 degrees from 0 to 180 degrees is ±2.5%. The percent depth dose (PDD) measurements were used to verify the energy dependence. The measured PDD using the MOSFETs from 0.5 cm to 34 cm depth agreed to within ±3% when compared to that of the ionization chamber. For IMRT dose verification, two special phantoms were designed. One is a solid water slab with 81 possible MOSFET placement holes, and another is a cylindrical phantom with 48 placement holes. For each IMRT phantom verification, an ionization chamber and 3 to 5 MOSFETs were used to measure multiple point doses at different locations. Preliminary results show that the agreement between dose measured by MOSFET and that calculated by Corvus is within 5% error, while the agreement between ionization chamber measurement and the calculation is within 3% error. In conclusion, MOSFET detectors are suitable for

  19. Clinical Research and the Training of Host Country Investigators: Essential Health Priorities for Disease-Endemic Regions.

    Science.gov (United States)

    Koita, Ousmane A; Murphy, Robert L; Fongoro, Saharé; Diallo, Boubakar; Doumbia, Seydou O; Traoré, Moussa; Krogstad, Donald J

    2016-02-01

    The health-care needs and resources of disease-endemic regions such as west Africa have been a major focus during the recent Ebola outbreak. On the basis of that experience, we call attention to two priorities that have unfortunately been ignored thus far: 1) the development of clinical research facilities and 2) the training of host country investigators to ensure that the facilities and expertise necessary to evaluate candidate interventions are available on-site in endemic regions when and where they are needed. In their absence, as illustrated by the recent uncertainty about the use of antivirals and other interventions for Ebola virus disease, the only treatment available may be supportive care, case fatality rates may be unacceptably high and there may be long delays between the time potential interventions become available and it becomes clear whether those interventions are safe or effective. On the basis of our experience in Mali, we urge that the development of clinical research facilities and the training of host country investigators be prioritized in disease-endemic regions such as west Africa. PMID:26598570

  20. Safeguards management inspection procedures

    Energy Technology Data Exchange (ETDEWEB)

    Barth, M.J.; Dunn, D.R.

    1984-08-01

    The objective of this inspection module is to independently assess the contributions of licensee management to overall safeguards systems performance. The inspector accomplishes this objective by comparing the licensee's safeguards management to both the 10 CFR, parts 70 and 73, requirements and to generally accepted management practices. The vehicle by which this comparison is to be made consists of assessment questions and key issues which point the inspector to areas of primary concern to the NRC and which raise additional issues for the purpose of exposing management ineffectiveness. Further insight into management effectiveness is obtained through those assessment questions specifically directed toward the licensee's safeguards system performance. If the quality of the safeguards is poor, then the inspector should strongly suspect that management's role is ineffective and should attempt to determine management's influence (or lack thereof) on the underlying safeguards deficiencies. (The converse is not necessarily true, however.) The assessment questions in essence provide an opportunity for the inspector to identify, to single out, and to probe further, questionable management practices. Specific issues, circumstances, and concerns which point to questionable or inappropriate practices should be explicitly identified and referenced against the CFR and the assessment questions. The inspection report should also explain why the inspector feels certain management practices are poor, counter to the CFR, and/or point to ineffecive management. Concurrent with documenting the inspection results, the inspector should provide recommendations for alleviating observed management practices that are detrimental to effective safeguards. The recommendations could include: specific changes in the practices of the licensee, followup procedures on the part of NRC, and proposed license changes.

  1. Laser Safety Inspection Criteria

    International Nuclear Information System (INIS)

    A responsibility of the Laser Safety Officer (LSO) is to perform laser audits. The American National Standard Z136.1 Safe Use of Lasers references this requirement through several sections. One such reference is Section 1.3.2.8, Safety Features Audits, ''The LSO shall ensure that the safety features of the laser installation facilities and laser equipment are audited periodically to assure proper operation''. The composition, frequency and rigor of that inspection/audit rests in the hands of the LSO. A common practice for institutions is to develop laser audit checklists or survey forms It is common for audit findings from one inspector or inspection to the next to vary even when reviewing the same material. How often has one heard a comment, ''well this area has been inspected several times over the years and no one ever said this or that was a problem before''. A great number of audit items, and therefore findings, are subjective because they are based on the experience and interest of the auditor to particular items on the checklist. Beam block usage, to one set of eyes might be completely adequate, while to another, inadequate. In order to provide consistency, the Laser Safety Office of the National Ignition Facility Directorate has established criteria for a number of items found on the typical laser safety audit form. The criteria are distributed to laser users. It serves two broad purposes; first, it gives the user an expectation of what will be reviewed by an auditor. Second, it is an opportunity to explain audit items to the laser user and thus the reasons for some of these items, such as labelling of beam blocks

  2. Safeguards management inspection procedures

    International Nuclear Information System (INIS)

    The objective of this inspection module is to independently assess the contributions of licensee management to overall safeguards systems performance. The inspector accomplishes this objective by comparing the licensee's safeguards management to both the 10 CFR, parts 70 and 73, requirements and to generally accepted management practices. The vehicle by which this comparison is to be made consists of assessment questions and key issues which point the inspector to areas of primary concern to the NRC and which raise additional issues for the purpose of exposing management ineffectiveness. Further insight into management effectiveness is obtained through those assessment questions specifically directed toward the licensee's safeguards system performance. If the quality of the safeguards is poor, then the inspector should strongly suspect that management's role is ineffective and should attempt to determine management's influence (or lack thereof) on the underlying safeguards deficiencies. (The converse is not necessarily true, however.) The assessment questions in essence provide an opportunity for the inspector to identify, to single out, and to probe further, questionable management practices. Specific issues, circumstances, and concerns which point to questionable or inappropriate practices should be explicitly identified and referenced against the CFR and the assessment questions. The inspection report should also explain why the inspector feels certain management practices are poor, counter to the CFR, and/or point to ineffecive management. Concurrent with documenting the inspection results, the inspector should provide recommendations for alleviating observed management practices that are detrimental to effective safeguards. The recommendations could include: specific changes in the practices of the licensee, followup procedures on the part of NRC, and proposed license changes

  3. Comparative study of Palito inspection and MFL Inspection

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Anne A. de; Miranda, Ivan Vicente Janvrot; Silva, Jose Augusto Pereira da [Pipeway Engenharia, Rio de Janeiro, RJ (Brazil); Guimaraes, Frederico S.; Magalhaes, Joao Alfredo P. [Minds at Work, Rio de Janeiro, RJ (Brazil); Sabino, Joao Marcos [Petroleo Brasileiro S.A. (PETROBRAS/UN-RN/CE), Natal, RN (Brazil). Unidade de Negocios Rio Grande do Norte e Ceara

    2009-07-01

    A 16 inches oil pipeline was surveyed with MFL and Palito pig in 2007. The MFL inspection was performed by Pipeway Engenharia while Palito inspection was performed by PETROBRAS. A comparison between the results of these two ILI inspections has been made to validate Palito Pig and to assess main characteristics and differences between the two techniques. The purpose of this paper is to detail the methodology applied to perform the comparison and to present a comparative study of results registered in the MFL and Palito inspections by Pipeway Engenharia, PETROBRAS/CENPES and CPTI/PUC-Rio. (author)

  4. The clinical significance of incidental intra-abdominal findings on positron emission tomography performed to investigate pulmonary nodules

    Directory of Open Access Journals (Sweden)

    Gill Richdeep S

    2012-01-01

    Full Text Available Abstract Background Lung cancer is a common cause of cancer-related death. Staging typically includes positron emission tomography (PET scanning, in which18F-fluoro-2-dexoy-D-glucose (FDG is taken up by cells proportional to metabolic activity, thus aiding in differentiating benign and malignant pulmonary nodules. Uptake of FDG can also occur in the abdomen. The clinical significance of incidental intraabdominal FDG uptake in the setting of pulmonary nodules is not well established. Our objective was to report on the clinical significance of incidental intra-abdominal FDG activity in the setting of lung cancer. Methods Fifteen hundred FDG-PET reports for studies performed for lung cancer were retrospectively reviewed for the presence of incidental FDG-positive intraabdominal findings. Patient charts with positive findings were then reviewed and information extracted. Results Twenty-five patients (25/1500 demonstrated incidental intraabdominal FDG uptake thought to be significant (1.7% with a mean patient age of 71 years. Colonic uptake was most common (n = 17 with 9 (52% being investigated further. Of these 9 cases, a diagnosis of malignancy was made in 3 patients, pre-malignant adenomas in 2 patients, a benign lipoma in 1 patient and no abnormal findings in the remaining patients. 8 patients were not investigated further (3 diagnosed with metastatic lung cancer and 2 were of advanced age secondary to poor prognosis. Conclusion Incidental abdominal findings in the colon on FDG-PET scan for work-up of pulmonary nodules need to be further investigated by colonoscopy.

  5. INSPECTION OF CNC MADE PARTS

    OpenAIRE

    Prof. Yogesh R. Falak*; Rahul Patil; Kalpesh Bhagat,

    2015-01-01

    Inspection is an important process of manufacturing system. It is means of rejecting error parts and assuring good quality parts. The advantages of technological innovation in inspection equipment helped to overcome the problems associated with traditional approaches. Such means that used of labour intensive method increase in total manufacturing time and production cost. Advanced sensor and inspection technologies, interfaced with computer based systems to automate the operations...

  6. Inspections - a cost effective approach

    International Nuclear Information System (INIS)

    This paper describes a cost effective approach for inspections of Computerized Nuclear Materials Control and Accounting Systems (CNMCAS). Highlighted is the capability to conduct an inspection program via portable telephone terminals from off-site locations. The program can be applied to various materials management functions including materials control, quality assurance, and materials accounting. The system is designed to facilitate inspections by both external and internal groups

  7. Waste inspection tomography (WIT)

    Energy Technology Data Exchange (ETDEWEB)

    Bernardi, R.T. [Bio-Imaging Research, Inc., Lincolnshire, IL (United States)

    1995-10-01

    Waste Inspection Tomography (WIT) provides mobile semi-trailer mounted nondestructive examination (NDE) and assay (NDA) for nuclear waste drum characterization. WIT uses various computed tomography (CT) methods for both NDE and NDA of nuclear waste drums. Low level waste (LLW), transuranic (TRU), and mixed radioactive waste can be inspected and characterized without opening the drums. With externally transmitted x-ray NDE techniques, WIT has the ability to identify high density waste materials like heavy metals, define drum contents in two- and three-dimensional space, quantify free liquid volumes through density and x-ray attenuation coefficient discrimination, and measure drum wall thickness. With waste emitting gamma-ray NDA techniques, WIT can locate gamma emitting radioactive sources in two- and three-dimensional space, identify gamma emitting, isotopic species, identify the external activity levels of emitting gamma-ray sources, correct for waste matrix attenuation, provide internal activity approximations, and provide the data needed for waste classification as LLW or TRU.

  8. Waste inspection tomography (WIT)

    International Nuclear Information System (INIS)

    The WIT program will provide an inspection system that offers the nuclear waste evaluator a unique combination of tools for regulatory-driven characterization of low-level waste (LLW), transuranic waste (TRU), and mixed waste drums. WIT provides nondestructive, noninvasive, and environmentally safe inspections using X-ray and gamma ray technologies, with reasonable cost and throughput. Two emission imaging techniques will be employed for characterizing materials in waste containers. The first of these is gamma emission tomography, commonly called single-photon emission computed tomography (SPECT). Rather than using an external radiation source, SPECT uses the emission of radioactive materials within the object of interest for imaging. In this case, emission from actual nuclear waste within a container will provide a three-dimensional image of the radioactive substances in the container. The second emission technique will use high-purity germanium detectors for gamma ray spectroscopy. This technique, called nondestructive assay (NDA), can identify the emitting isotopic species and strength. Work in emission tomography and assay of nuclear waste has been undertaken at Lawrence Livermore National Laboratory using a technique called Passive Tomography. Results from a process development unit are presented

  9. Ultrasonic wave inspection device

    International Nuclear Information System (INIS)

    The device of the present invention inspects incore structural components by visualizing them by scanning an ultrasonic transducer in an opaque liquid metal sodium in a pressure vessel of an FBR type reactor. Namely, a piezoelectric vibrator for transmitting/receiving ultrasonic waves is formed into a protruded shape. A portion at the center of the protruded piezoelectric vibrator is coaxially separated. Upon transmitting ultrasonic waves, a large opening of the entire piezoelectric vibrator is used. A small opening at the center of the piezoelectric vibrator is used upon receiving ultrasonic waves. With such a constitution, an object to be inspected is visualized based on the waveform of the received ultrasonic wave signals defining the center of a curvature of the protruded piezoelectric vibrator as a position of transmitting ultrasonic waves and defining the center of the opening at the center of the piezoelectric vibrator as a position of receiving ultrasonic waves. As a result, the energy of the ultrasonic waves can be enhanced to improve sensitivity upon transmitting ultrasonic waves. Since the distance between an optional position of the receiving surface and the reflecting surface of the object is minimized upon receiving ultrasonic waves, there is no distortion in the waveforms of the received signals thereby enabling to obtain images at high accuracy. (I.S.)

  10. Inspection system performance test procedure

    International Nuclear Information System (INIS)

    This procedure establishes requirements to administer a performance demonstration test. The test is to demonstrate that the double-shell tank inspection system (DSTIS) supplied by the contractor performs in accordance with the WHC-S-4108, Double-Shell Tank Ultrasonic Inspection Performance Specification, Rev. 2-A, January, 1995. The inspection system is intended to provide ultrasonic (UT) and visual data to determine integrity of the Westinghouse Hanford Company (WHC) site underground waste tanks. The robotic inspection system consists of the following major sub-systems (modules) and components: Mobile control center; Deployment module; Cable management assembly; Robot mechanism; Ultrasonic testing system; Visual testing system; Pneumatic system; Electrical system; and Control system

  11. Optimal allocation of inspection resources

    International Nuclear Information System (INIS)

    Allocation of inspection resources for international safeguards is considered as the problem of designing a complex system that is composed of individual inspection activities and that has the objective of detecting material loss. Optimization theory is applied in selecting those inspection activities that maximize a system performance measure within resource constraints. The method is applicable to a global allocation problem in which inspection resources are distributed throughout a hierarchy consisting of multiple countries, multiple facilities within each country, and multiple activities within each facility. 9 references

  12. Cerebral perfusion studies using Au-195: Investigations into their clinical usefulness and comparisons with the xenon-133 inhalation method

    International Nuclear Information System (INIS)

    Au-195m cerebral perfusion studies in the diagnosis of blood supply disorders of the brain have only recently leaped into currency. Au-195m is not capable of diffusing. This particular property permits first-pass times of vascular transfer to be determined for cerebral tissues that correlate with the degree of cerebral circulation. In the study described here, attempts were made to shed more light on the clinical usefulness of the method. For this purpose, the record sheets of two cohorts of patients were analysed on a retrospective basis. 1. In 23 patients, where the cerebrovascular disorders were strictly confined to the cerebral hemispheres, the blood supply of the brain was examined on the basis of both Au-195m cerebral perfusion studies and the xenon-133 inhalation method. In the evaluation of the findings based on the Au-195m study the investigator was blinded to the neurological manifestations of the disease and the results from other studies. In 82% of the patients the perfusion mapping using Au-195m was consistent with the clinical symptoms. 2. In a second group of patients, the probable results of the Au-195m perfusion study were forecasted on the basis of the medical history, clinical symptoms and preliminary diagnosis and subsequently compared to those actually obtained. Expected and actual results were found to be in agreement for 88% of cases. The results provided evidence of the suitability of Au-195m cerebral perfusion studies to examine the blood suply of the brain. In view of the fact that the examinations and measurements are relatively uncomplicated, this newly developed method is most likely to be used on a broader basis in the future. (orig./MG)

  13. [Outbreak of carpal tunnel syndrome of the upper limbs in automobile seat assemblers: results of exposure evaluation and clinical investigation].

    Science.gov (United States)

    Barbieri, P G; Colombini, D; Rocco, A; Custureri, F; Paderno, G

    1996-01-01

    A group of 59 female workers in the sewing and upholstery departments of a factory manufacturing automobile seats underwent clinical and instrumental tests following reports of several cases of suspected carpal tunnel syndrome. A risk evaluation analysis for disorders attributable to repeated trauma of the upper limbs (WMSDs) was simultaneously carried out using the protocol recommended by the EPM Research Unit in Milan. Evidence was found of a high frequency of elementary actions associated with considerable muscular involvement along with inadequate recovery periods. The clinical investigation revealed an unusually high percentage of carpal tunnel syndromes, often associated with Guyon channel syndrome. This disorder affects males and females equally, is often bilateral, and is not associated with known non-occupational factors. The widespread outbreak of work-related musculo-skeletal disorders reported in the departments in question may have arisen from a combination of significant risk factors relating to the types of activities performed, and the long service of the workers. It is reasonable to assume that failure to adopt technical preventive and organisational measures may have stemmed primarily from a poor evaluation of the relevant occupational risks, and from many years of substandard health surveillance practices. PMID:9148122

  14. Clinical and Pathological Findings in Green Turtles (Chelonia mydas) from Gladstone, Queensland: Investigations of a Stranding Epidemic.

    Science.gov (United States)

    Flint, Mark; Eden, Paul A; Limpus, Colin J; Owen, Helen; Gaus, Caroline; Mills, Paul C

    2015-06-01

    An investigation into the health of green turtles was undertaken near Gladstone, Queensland, in response to a dramatic increase in stranding numbers in the first half of 2011. A total of 56 live turtles were subject to clinical examination and blood sampling for routine blood profiles, and 12 deceased turtles underwent a thorough necropsy examination. This population of green turtles was found to be in poor body condition and a range of infectious and non-infectious conditions were identified in the unhealthy turtles, including hepato-renal insufficiency (up to 81%, 27/33 based on clinical pathology), cachexia (92%, 11/12), parasitism (75%, 9/12), cardiopulmonary anomalies (42%, 5/12), gastroenteritis (25%, 3/12), masses (25%, 3/12) and mechanical impediments (17%, 2/12 based on necropsy). Overall, there was no evidence to indicate a unifying disease as a primary cause of the mass mortality. Recent adverse weather events, historic regional contamination and nearby industrial activities are discussed as potential causative factors. PMID:25256011

  15. An investigation of general predictors for cognitive behavioral therapy outcome for anxiety disorders in a routine clinical setting

    DEFF Research Database (Denmark)

    Nielsen, Sara Kerstine Kaya; Vangkilde, Signe; Wolitzky-Taylor, Kate B.;

    2016-01-01

    predictors of treatment effects are lacking. The aim of this study is to investigate the predictive value of emotion regulation and attentional control for CBT outcome in a routine setting. METHODS AND ANALYSIS: In this prospective and practice-based study, 112 patients with anxiety disorders referred for......-up. Emotion regulation will be measured with Difficulties in Emotion Regulation Questionnaire, severity of anxiety will be assessed with Beck Anxiety Inventory and attentional control will be measured with the self-report questionnaire, Attention Control Scale, and with an experimental computer...... manual-based group CBT at two psychiatric outpatient clinics will be recruited. Emotion regulation, severity of anxiety and attentional control will be assessed with self-report measures and with an experimental computer-based attentional control task at baseline, post-treatment and at a 6-month follow...

  16. Clinical investigation of predictors of radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy

    International Nuclear Information System (INIS)

    We investigated 710 patients with breast cancer who received radiotherapy after breast-conserving surgery at our institution to evaluate the incidence of radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome focusing on the interval from irradiation to onset and the clinical presentation. The predictive value of age (≤50 or >50), chemotherapy and hormone therapy was statistically analyzed to determine whether these are risk factors for BOOP syndrome. Radiation-induced BOOP syndrome was seen in 1.3% (9/710). In most cases, the symptoms were mild and none of the patients required hospitalization. Eight patients (88.9%) responded well to steroid administration, but 5 of these patients relapsed after or during tapering of steroids. Although we could not detect significant risk factors for BOOP syndrome, a higher patient age was associated with a higher incidence of radiation-induced BOOP syndrome after breast-conserving therapy. (author)

  17. Laser Safety Inspection Criteria

    International Nuclear Information System (INIS)

    A responsibility of the Laser Safety Officer (LSO) is to perform laser safety audits. The American National Standard Z136.1 Safe use of Lasers references this requirement in several sections: (1) Section 1.3.2 LSO Specific Responsibilities states under Hazard Evaluation, ''The LSO shall be responsible for hazards evaluation of laser work areas''; (2) Section 1.3.2.8, Safety Features Audits, ''The LSO shall ensure that the safety features of the laser installation facilities and laser equipment are audited periodically to assure proper operation''; and (3) Appendix D, under Survey and Inspections, it states, ''the LSO will survey by inspection, as considered necessary, all areas where laser equipment is used''. Therefore, for facilities using Class 3B and or Class 4 lasers, audits for laser safety compliance are expected to be conducted. The composition, frequency and rigueur of that inspection/audit rests in the hands of the LSO. A common practice for institutions is to develop laser audit checklists or survey forms. In many institutions, a sole Laser Safety Officer (LSO) or a number of Deputy LSO's perform these audits. For that matter, there are institutions that request users to perform a self-assessment audit. Many items on the common audit list and the associated findings are subjective because they are based on the experience and interest of the LSO or auditor in particular items on the checklist. Beam block usage is an example; to one set of eyes a particular arrangement might be completely adequate, while to another the installation may be inadequate. In order to provide more consistency, the National Ignition Facility Directorate at Lawrence Livermore National Laboratory (NIF-LLNL) has established criteria for a number of items found on the typical laser safety audit form. These criteria are distributed to laser users, and they serve two broad purposes: first, it gives the user an expectation of what will be reviewed by an auditor, and second, it is an

  18. Labor inspection in Brazil

    Directory of Open Access Journals (Sweden)

    Adalberto Cardoso

    2006-01-01

    Full Text Available One aspect the literature overlooks on the effects of labor regulation of labor market efficiency is the degree of the legislation's effectiveness, i.e., its actual enforcement in daily work relations. Even the more sophisticated econometric studies (which take into account the effects of interaction between labor market regulatory institutions in explaining its dynamics leave this central issue aside, namely enforcement versus non-enforcement of the law. Keeping this issue in mind, we seek to answer the following question in this article: given that the effectiveness of labor legislation depends on the interaction between the overall sanctions and the probability of the employer getting caught breaking the law, and given that the law's effectiveness is a decisive aspect for the real measurement of a country's labor costs, to what extent is the Brazilian labor inspection system designed to meet its objective, namely, to enforce the law?

  19. Automated visual inspection of textile

    DEFF Research Database (Denmark)

    Jensen, Rune Fisker; Carstensen, Jens Michael

    A method for automated inspection of two types of textile is presented. The goal of the inspection is to determine defects in the textile. A prototype is constructed for simulating the textile production line. At the prototype the images of the textile are acquired by a high speed line scan camera...

  20. Inspection of disposal canisters components

    International Nuclear Information System (INIS)

    This report presents the inspection techniques of disposal canister components. Manufacturing methods and a description of the defects related to different manufacturing methods are described briefly. The defect types form a basis for the design of non-destructive testing because the defect types, which occur in the inspected components, affect to choice of inspection methods. The canister components are to nodular cast iron insert, steel lid, lid screw, metal gasket, copper tube with integrated or separate bottom, and copper lid. The inspection of copper material is challenging due to the anisotropic properties of the material and local changes in the grain size of the copper material. The cast iron insert has some acoustical material property variation (attenuation, velocity changes, scattering properties), which make the ultrasonic inspection demanding from calibration point of view. Mainly three different methods are used for inspection. Ultrasonic testing technique is used for inspection of volume, eddy current technique, for copper components only, and visual testing technique are used for inspection of the surface and near surface area

  1. Planning and performance of inspections

    International Nuclear Information System (INIS)

    Inspections in power plants are decisive factors for profitable and safe power production. Inspection schedulling needs to consider output demand, fuel application, manufacturers' recommendations and, above all, operational records of the state of the plant. Inspection schedulling is aimed at finding an optimum time-to-cost ratio for a defined scope of inspection. A large utility with a power plant pool featuring nuclear, black coal, brown coal, gas and hydro electric plants makes great and varied demands on inspection schedulling and implementation which the author exemplifies by PreussenElektra with its installed capacity of ca. 12,000 MW distributed among 7 nuclear power plants, 20 coal and gas units, 10 pump storage units and 40 run-of-river turbines. (orig./GL)

  2. Improving the reliability of on-site NDT inspection

    International Nuclear Information System (INIS)

    The authors review the conclusions of a number of projects conducted at AEA Technology to determine the effects of various possible factors which can affect the reliability of inspections during nuclear power plan maintenance outage. The factors investigated include: working practices and work scheduling (effect of long working hours and time pressures), the local environment (effects of temperature, humidity, noise), the inherent capability of the inspectors (influence of the inspector's training, qualifications, experience and attitude), inspection systems and procedures (relative performances of manual and automated inspections, role of validation and procedure assessment)

  3. Inspection of licensed nuclear power plants in the United States

    International Nuclear Information System (INIS)

    Inspection of licensed nuclear power plants in the United States is performed by the Office of Inspection and Enforcement (IE), United States Nuclear Regulatory Commission. IE has several key functions : a) Inspection of licensees and investigation of incidents, occurrences and allegations. b) Detection and correction of safety and security problems. c) Enforcement of rules, regulations, and Commission orders. d) Feedback to the industry and others regarding safety experience. e) Informing the public and others. Major enforcement actions and events involving operating power reactors for the past several years will be summarized. (author)

  4. Comparison analysis of the pre-pregnancy clinical inspection result be-tween rural and urban population%农村和城镇人群孕前临床检查结果的比较分析

    Institute of Scientific and Technical Information of China (English)

    冯文霄; 金瑛

    2015-01-01

    Objective To explore the health inspection and risk assessment of rural and urban pre-pregnancy people in Liaoning province. Methods 208 019 rural and urban couples participated in the free pre-pregnancy health inspection from January 2013 to December in Liaoning province were selected as the research object.The inspection result and high-risk rate between the rural and urban people were compared. Results The inspection result of routine physical ex-amination,reproductive system examination,pre-pregnancy check leukorrhea routine examination,Gonococcus,Chlamydia trachomatis,serum glucose,liver function,renal function,five items of hepatitis B,gynecological ultrasound examination between the rural and urban pre-pregnancy people was compared respectively,with significant difference (P<0.05). Conclusion The educational measures should be developed according to the different health status of rural and urban pre-pregnancy people in order to reduce the occurrence rate of birth defects in our province.%目的:探讨辽宁省农村和城镇孕前人群的健康检查和高风险评估情况。方法选取辽宁省2013年1~12月参加免费孕前优生健康检查的208019名农村和城镇夫妇作为研究对象,比较农村和城镇的检查结果和高风险率。结果农村孕前人群的常规体格检查、生殖系统检查、白带常规、淋球菌、沙眼衣原体、血清葡萄糖、肝功能、乙肝五项、肾功能、妇科超声检查结果和高风险发生率与城镇孕前人群比较,差异有统计学意义(P<0.05)。结论根据农村和城镇孕前人群的不同健康状况,制订有针对性的宣教措施,以降低本省的出生缺陷发生率。

  5. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organizations during the period from July 1989 through September 1989

  6. Licensee contractor and Vendor Inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organizations during the period from October 1992 through December 1992

  7. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organization during the period from January 1991 through March 1991

  8. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organizations during the period from October 1989 through December 1989

  9. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organizations during the period from April through June 1993

  10. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organizations during the period from January 1993 through March 1993

  11. Licensee contractor and Vendor Inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organizations during the period from January through March 1992

  12. Licensee Contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organization during the period from October through December 1991

  13. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organization during the period from January 1990 through March 1990

  14. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organization during the period from April 1990 through June 1990

  15. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organization during the period from July 1992 through September 1992

  16. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organizations during the period from October 1990 through December 1990

  17. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organization during the period from April 1991 through June 1991

  18. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organization during the period from July 1991 through September 1991

  19. Clinical investigation compared with the effects of the bee-venom Acupuncture on knee joint with osteoarthritis

    Directory of Open Access Journals (Sweden)

    Wang Wu-Hao

    2001-12-01

    Full Text Available Objective: This study is designed to find out the effects of the Bee-Venom Acupuncture on knee joint with osteoarthritis. Methods: We are investigated that outpatients suffer from knee joint pain deciphered at the division of Acupuncture in Jaseng oriental medicine hospital from the 13, July 1999 to unti111, November 2000. We make an estimated of the score from both before or after its treatment about 70 cases of diagnostic patient with the osteoarthritis of knee joints by biochemical method and X-RAY analysis, we observed in the progress of symptoms. Results: These results found that sex distinction with a disease caused much more female than male at the ratio of I to 5.36 in the proportion of males to females, jobs is mainly ranked with a housewife and approximately 82.9% of cases before our hospital have ever treated at the other clinics or hospitals. On the hand, the distribution interval of a case history is mainly followed by disease in below 6 month, interval of the period-treatment is mainly gone within 3 month and frequency of treatment is examined into II to 15 times, more than 16 times and below 10 times, respectively. We are estimated with the score of functional barrier from both before or after its treatment against osteoarthritis' patients and produced in the usefulness from the totally point of fields except the aid-device after its treatment In summary, these results demonstrated that Bee Venom, Acupuncture enhanced more than 82.9% to the improvement of treatment and p<0.05 considered to be statistically significant. Conclusion: These results suggest that Bee-venom Acupuncture may be playa role in the significant usefulness and have need of actively application for the clinical trials against osteoarthritis' patients.

  20. Periodic inspection for safety of CANDU heat transport piping systems

    International Nuclear Information System (INIS)

    An approach has been developed for the prediction of the risk of failure or the survival of heat transport piping systems in a nuclear power plant. The effects of various inspection schemes on the risk of failure have been investigated and an inspection method proposed. A list of input data required to apply this method to real situations is specified. Using an example of a pressurized pipe containing a defect, it is shown that the required data can be obtained easily

  1. From PISC to risk informed inspection

    International Nuclear Information System (INIS)

    In this paper the correlation between inspection effectiveness, inspection qualification and risk informed inspection will be treated in view of harmonisation of inspection of nuclear plant components. Through the different phases of the PISC programme the necessity has been demonstrated to show the effectiveness of the inspection through a formal process of qualification in order to ensure that a certain level of effectiveness has been reached. Inspection qualification is indeed the way to quantify the capability level of inspection techniques used. The targets to be met by the inspection is information which should be obtained from risk based analyses. (author)

  2. Tools for nuclear inspection

    International Nuclear Information System (INIS)

    IAEA nuclear inspectors have a range of high-tech tools at their disposal. Over the last decade, there have been significant improvements in the technology they use, mostly software advances make equipment more powerful and provide faster results. As they gather evidence, inspectors use a broad array of technologies, such as hand held radiation detectors and measurement instruments. Some instruments are used to search for nuclear and radioactive materials known to be associated with weapons making. Others can identify specific radioactive elements in samples that inspectors collect for fuller analysis in laboratories. Methods and equipment used include swipe sampling, multi-channel analyzers (MCAs), alloy detectors (ALEX), environmental monitoring instruments, digital video surveillance systems, satellite imagery and inspection databases. The IAEA has its own experts and facilities, through its Safeguards Analytical Laboratory in Austria, experienced in sample measurements and analysis. A 'Clean Laboratory' equipped with highly sensitive instruments including electron microscopes and mass-spectrometers is operational there. Network labs involved are in Australia, France, Germany, Japan, Russia, united Kingdom and the United States

  3. Final inspection of photomask blanks

    Science.gov (United States)

    Schubert, Fredi; Sauerbrei, Hartmut; Aschke, Lutz; Knapp, Konrad

    2001-04-01

    In order to increase the quality in manufacturing of future photon mask generations Schott Lithotec is brought in a brand new, much increased automatic laser inspection system into a new manufacturing line of photo mask blanks. It is in a position to detect additionally to the standard defect types further defect types like dim- and bright-chrome defects. The resolution of the system is less than 100 nm. With a quickly inspecting time per blank of less than three minutes and for the first time in the world used automatic SMIF-pod-handling this is a tool for the 100 percent final inspection in the manufacturing of photo mask blanks.

  4. Non-destructive inservice inspections

    International Nuclear Information System (INIS)

    In order to assess the possible damages occurring in the components and structures of operating nuclear power plants during service the main components and structures are periodically inspected by non-destructive testing techniques. The reliability of non-destructive testing techniques applied in these inservice inspections is of major importance because the decisions concerning the needs for repair of components are mainly based on the results of inspections. One of the targets of this research program has been to improve the reliability of non-destructive testing. This has been addressed in the sub-projects which are briefly summarised here. (author)

  5. Inspection technology for high pressure pipes

    International Nuclear Information System (INIS)

    Various kinds of defects are likely to be occurred in the welds of high pressure pipes in nuclear power plants. Considering the recent accident of Zuruga nuclear power plant in Japan, reasonable policy is strongly requested for the high pressure pipe integrity. In this study, we developed the technologies to inspect pipe welds automatically. After development of scanning robot prototype in the first research year, we developed and implemented the algorithm of automatic tracking of the scanning robot along the weld line of the pipes. We use laser slit beam on weld area and capture the image using digital camera. Through processing of the captures image, we finally determine the weld line automatically. In addition, we investigated a new technology on micro systems for developing micro scanning robotic inspection of the pipe welds. The technology developed in this study is being transferred to the industry. (author)

  6. Investigation of multichannel phased array performance for fetal MR imaging on 1.5T clinical MR system.

    Science.gov (United States)

    Li, Ye; Pang, Yong; Vigneron, Daniel; Glenn, Orit; Xu, Duan; Zhang, Xiaoliang

    2011-01-01

    Fetal MRI on 1.5T clinical scanner has been increasingly becoming a powerful imaging tool for studying fetal brain abnormalities in vivo. Due to limited availability of dedicated fetal phased arrays, commercial torso or cardiac phased arrays are routinely used for fetal scans, which are unable to provide optimized SNR and parallel imaging performance with a small number coil elements, and insufficient coverage and filling factor. This poses a demand for the investigation and development of dedicated and efficient radiofrequency (RF) hardware to improve fetal imaging. In this work, an investigational approach to simulate the performance of multichannel flexible phased arrays is proposed to find a better solution to fetal MR imaging. A 32 channel fetal array is presented to increase coil sensitivity, coverage and parallel imaging performance. The electromagnetic field distribution of each element of the fetal array is numerically simulated by using finite-difference time-domain (FDTD) method. The array performance, including B(1) coverage, parallel reconstructed images and artifact power, is then theoretically calculated and compared with the torso array. Study results show that the proposed array is capable of increasing B(1) field strength as well as sensitivity homogeneity in the entire area of uterus. This would ensure high quality imaging regardless of the location of the fetus in the uterus. In addition, the paralleling imaging performance of the proposed fetal array is validated by using artifact power comparison with torso array. These results demonstrate the feasibility of the 32 channel flexible array for fetal MR imaging at 1.5T. PMID:22408747

  7. Clinical multiphoton FLIM tomography

    Science.gov (United States)

    König, Karsten

    2012-03-01

    This paper gives an overview on current clinical high resolution multiphoton fluorescence lifetime imaging in volunteers and patients. Fluorescence lifetime imaging (FLIM) in Life Sciences was introduced in Jena/Germany in 1988/89 based on a ZEISS confocal picosecond dye laser scanning microscope equipped with a single photon counting unit. The porphyrin distribution in living cells and living tumor-bearing mice was studied with high spatial, temporal, and spectral resolution. Ten years later, time-gated cameras were employed to detect dental caries in volunteers based on one-photon excitation of autofluorescent bacteria with long fluorescence lifetimes. Nowadays, one-photon FLIM based on picosecond VIS laser diodes are used to study ocular diseases in humans. Already one decade ago, first clinical twophoton FLIM images in humans were taken with the certified clinical multiphoton femtosecond laser tomograph DermaInspectTM. Multiphoton tomographs with FLIM modules are now operating in hospitals at Brisbane, Tokyo, Berlin, Paris, London, Modena and other European cities. Multiple FLIM detectors allow spectral FLIM with a temporal resolution down to 20 ps (MCP) / 250 ps (PMT) and a spectral resolution of 10 nm. Major FLIM applications include the detection of intradermal sunscreen and tattoo nanoparticles, the detection of different melanin types, the early diagnosis of dermatitis and malignant melanoma, as well as the measurement of therapeutic effects in pateints suffering from dermatitis. So far, more than 1,000 patients and volunteers have been investigated with the clinical multiphoton FLIM tomographs DermaInspectTM and MPTflexTM.

  8. Women with TSC: Relationship between Clinical, Lung Function and Radiological Features in a Genotyped Population Investigated for Lymphangioleiomyomatosis.

    Directory of Open Access Journals (Sweden)

    Fabiano Di Marco

    Full Text Available The advent of pharmacological therapies for lymphangioleiomyomatosis (LAM has made early diagnosis important in women with tuberous sclerosis complex (TSC, although the lifelong cumulative radiation exposure caused by chest computer tomography (CT should not be underestimated. We retrospectively investigated, in a cohort of TSC outpatients of San Paolo Hospital (Milan, Italy 1 the role of pulmonary function tests (PFTs for LAM diagnosis, 2 the association between LAM and other features of TSC (e.g. demography, extrapulmonary manifestations, genetic mutations, etc., and 3 the characteristics of patients with multifocal micronodular pneumocyte hyperplasia (MMPH. Eighty-six women underwent chest CT scan; pulmonary involvement was found in 66 patients (77%; 49% LAM with or without MMPH, and 28% MMPH alone. LAM patients were older, with a higher rate of pneumothorax, presented more frequently with renal and hepatic angiomyolipomas, and tended to have a TSC2 mutation profile. PFTs, assessed in 64% of women unaffected by cognitive impairments, revealed a lower lung diffusion capacity in LAM patients. In multivariate analysis, age, but not PFTs, resulted independently associated with LAM diagnosis. Patients with MMPH alone did not show specific clinical, functional or genetic features. A mild respiratory impairment was most common in LAM-TSC patients: In conclusions, PFTs, even if indicated to assess impairment in lung function, are feasible in a limited number of patients, and are not significantly useful for LAM diagnosis in women with TSC.

  9. An investigation on clinical radiological diagnosis of hereditary osteogenesis imperfect (a report of 42 patients in a family)

    International Nuclear Information System (INIS)

    Purpose: To investigate the main points of diagnosing hereditary osteogenesis imperfect. Methods: Retrospective analysis of clinical and radiological diagnosis of hereditary osteogenesis imperfect was done in 35 surviving patients and 7 deaths in a family. Results: (1) A family was described in which hereditary osteogenesis imperfect occurred in 5 generations. Forty-two patients (18 males, 24 females) ranged in age from 10 months to 67 years. (2) Both modes of inheritance existed simultaneously (dominant in 35 patients, recessive in 7 patients). (3) Blue sclera of different shades was found in all 42 patients. (4) Radiological change of bone was recognised in 35 surviving patients. The conditions were as follows: in 29 patients, general decreased bone density, thin bone cortex and long slender tubular bones were observed; six patients were normal; twenty-two patients had fracture. (5) Twenty-four patients (including 3 deaths) suffered form progressive deafness. (6) Twenty-one patients (including 3 deaths) had the triad of blue sclera, osteopsathyrosis and progressive deafness. (7) An increase in alkaline phosphatase level (in 17 patients) was confirmed by the tests in our laboratory. Conclusion: The authors suggested that the triad of blue sclera, osteopsathyrosis and progressive deafness is the characteristic manifestations of the disease, especially blue sclera, which may be regarded as an initial and suggestible physical sign, and an essential criterion for diagnosis

  10. Trueness investigation of routine creatinine assays on nine homogeneous systems in Beijing demonstrates an encouraging outcome that meets clinical requirements

    Institute of Scientific and Technical Information of China (English)

    LIU Yan; XU Guo-bin

    2010-01-01

    Background Serum creatinine (Scr) measurement plays a key role in glomerular filtration rate estimation (eGFR),chronic kidney disease (CKD) diagnosis as well as CKD treatment. However, the test results of Scr from different laboratories vary significantly. In order to get comparable results, the European in vitro diagnostic (IVD) directive requires traceability to reference methods and materials. The purpose of this study was to verify the effect of traceability implementation by investigating the trueness of creatinine measurement on nine homogenous systems in Beijing. Methods Commutable frozen human serum reference material, National Institute of Standards & Technology (NIST) Standard Reference Material (SRM) 967, was used to verify the trueness of Scr measurement results from nine homogeneous analytical systems of seven companies which are the most widely used systems in Beijing's third-grade hospitals. The methods referred to the Jaffe's and Enzymatic methods. Results from nine routine measurement systems were assessed using two criteria: biological variability and Clinical Laboratory Improvement Amendments' 88 (CLIA' 88).We simulated a series of broken lines representing the limits of SD and bias that would produce a relative increase (or decrease) of 10% and 20% in the measurement error when estimating GFR (MEeGFR) using the isotope dilution mass spectrometry (IDMS)-traceable Modification of Diet in Renal Disease (MDRD) Study equation. Results of the College of American Pathologists (CAP) 2008-B LN24 Survey were compared with our investigation results. Results Compared with the total error criteria of biological variability, Ortho (traceable to IDMS) met the minimum acceptable criteria; Roche (Jaffe), Roche (Enzymatic), Shino and Daiichi met the desirable criteria at level Ⅰ. At level Ⅱ, Ortho (traceable to gas chromatography/isotope dilution mass spectrometry, GC/IDMS), Dade Behring and Beckman (traceable to rate Jaffe) met the minimum acceptable

  11. Simulation examples of ultrasonic inspection

    International Nuclear Information System (INIS)

    The paper gives examples of application of two very different computer programs that are used to simulate and model ultrasonic inspection. The real propagation path of the sound beam can be difficult to trace when the geometry is complex. Ray tracing simulation on a three dimensional model of the inspection geometry can be very useful and sometimes nearly a necessity to analyse the probe angles and scanning paths. The modelling of the sound pulse behaviour in the material and its interaction with geometric details and defects produces information about the signals that can occur during the inspection. Simulation examples show how information can be generated to support inspection design, data analyses and qualification. (orig.)

  12. Incore inspection and repairing device

    International Nuclear Information System (INIS)

    The present invention provides a device for inspecting and repairing the inside of a reactor container even if it is narrow, with no trouble by using a swimming-type operation robot. Namely, the device of the present invention conducts inspection and repairing operations for the inside of the reactor by introducing a swimming type operation robot into the reactor container. The swimming-type operation robot comprises a robot main body having a propeller, a balancer operably disposed to the robot main body and an inspection and repairing unit attached detachable to the balancer. In the device of the present invention, since the inspection and preparing unit is attached detachably to the swimming robot, a robot which transports tools is formed as a standard product. As a result, the production cost can be reduced, and the reliability of products can be improved. Appropriate operations can be conducted by using best tools. (I.S.)

  13. Multifamily Housing Physical Inspection Scores

    Data.gov (United States)

    Department of Housing and Urban Development — HUD's Real Estate Assessment Center conducts physical property inspections of properties that are owned, insured or subsidized by HUD, including public housing and...

  14. National Automated Conformity Inspection Process

    Data.gov (United States)

    Department of Transportation — The National Automated Conformity Inspection Process (NACIP) Application is intended to expedite the workflow process as it pertains to the FAA Form 81 0-10 Request...

  15. CIGAR - a remote inspection system

    International Nuclear Information System (INIS)

    CIGAR (Channel Inspection and Gauging Apparatus for Reactors) is an automated system that has been developed by Ontario Hydro, Canadian General Electric and AECL for the inspection of pressure tubes in CANDU reactors. It performs volumetric flaw detection, diameter and wall thickness measurement, sag profile measurement and spacer location determination. The inspection systems employed may have application in other situations and they well demonstrate the capabilities that exist in Canada for the development of sophisticated technology to solve complex problems. Part 1 of this paper discusses the requirements for the system and describes the CIGAR inspection, data acquisition and processing components that were developed by Ontario Hydro's Research Division. Part 2 describes the CIGAR delivery system that was developed by Canadian General Electric

  16. Sea bed mapping and inspection

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The conference has 24 presentations on the topics: Sea bed mapping, inspection, positioning, hydrography, marine archaeology, remote operation vehicles and computerized simulation technologies, oil field activities and plans, technological experiences and problems. (tk)

  17. Ultrasonic Inspection Of Thick Sections

    Science.gov (United States)

    Friant, C. L.; Djordjevic, B. B.; O'Keefe, C. V.; Ferrell, W.; Klutz, T.

    1993-01-01

    Ultrasonics used to inspect large, relatively thick vessels for hidden defects. Report based on experiments in through-the-thickness transmission of ultrasonic waves in both steel and filament-wound composite cases of solid-fuel rocket motors.

  18. Ultrasonic inspection of austenitic welds

    International Nuclear Information System (INIS)

    The metallurgical structure of austenitic welds is described and contrasted with that found in ferritic welds. It is shown that this structure imparts a marked elastic anisotropy in the ultrasonic propagation parameters. Measurements of variations in the apparent attenuation of sound and deviations in the beam direction are described. The measurements are interpreted in terms of the measured velocity anisotropy. Two applications of the fundamental work are described. In the first it is shown how, by using short pulse compression wave probes, and with major modification of the welding procedure, a stainless steel fillet weld in an AGR boiler can be inspected. In the second application, alternative designs of a transition butt weld have been compared for ease of ultrasonic inspection. The effects of two different welding processes on such an inspection are described. Finally, the paper examines the prospects for future development of inspection and defect-sizing techniques for austenitic welds. (author)

  19. Public Housing Physical Inspection Scores

    Data.gov (United States)

    Department of Housing and Urban Development — HUD's Real Estate Assessment Center conducts physical property inspections of properties that are owned, insured or subsidized by HUD, including public housing and...

  20. An investigation into the clinical reasoning of cardiorespiratory physiotherapists using a simulated patient and simulated high dependency unit

    OpenAIRE

    Thackray, Debbie

    2014-01-01

    The ability of physiotherapists to make clinical decisions is understood to be a vital component of achieving expertise and is part of being an autonomous practitioner, yet this complex phenomenon has been under-researched in cardiorespiratory physiotherapy. Educators in this field need to understand what method of clinical reasoning clinicians are using, so that educational strategies can be designed to facilitate the development of clinical reasoning by undergraduate physiotherapy students ...

  1. Virtual World Security Inspection

    Directory of Open Access Journals (Sweden)

    Nicholas Charles Patterson

    2012-06-01

    Full Text Available Virtual property theft is a serious problem that exists in virtual worlds. Legitimate users of these worlds invest considerable amounts of time, effort and real-world money into obtaining virtual property, but unfortunately, are becoming victims of theft in high numbers. It is reported that there are over 1 billion registered users of virtual worlds containing virtual property items worth an estimated US$50 billion dollars. The problem of virtual property theft is complex, involving many legal, social and technological issues. The software used to access virtual worlds is of great importance as they form the primary interface to these worlds and as such the primary interface to conduct virtual property theft. The security vulnerabilities of virtual world applications have not, to date, been examined. This study aims to use the process of software inspection to discover security vulnerabilities that may exist within virtual world software – vulnerabilities that enable virtual property theft to occur. Analyzing three well know virtual world applications World of Warcraft, Guild Wars and Entropia Universe, this research utilized security analysis tools and scenario testing with focus on authentication, trading, intruder detection and virtual property recovery. It was discovered that all three examples were susceptible to keylogging, mail and direct trade methods were the most likely method for transferring stolen items, intrusion detection is of critical concern to all VWEs tested, stolen items were unable to be recovered in all cases and lastly occurrences of theft were undetectable in all cases. The results gained in this study present the key problem areas which need to be addressed to improve security and reduce the occurrence of virtual property theft.

  2. Automation of painted slate inspection

    OpenAIRE

    Carew, Tim

    2002-01-01

    This thesis is concerned with the problem of how to detect visual defects on painted slates using an automated visual inspection system. The vision system that has been developed consists of two major components. The first component addresses issues such as the mechanical implementation and interfacing the inspection system with the optical and sensing equipment whereas the second component involves the development of an image processing algorithm able to identify the visual defects present o...

  3. Ultrasonic nondestructive tubing inspection system

    International Nuclear Information System (INIS)

    A system for measuring the extent of tube wall erosion in an inspection region of a heat exchanger tube of a nuclear steam generator, uses an ultrasonic means driven helically inside the eroded tube which may be filled with a fluid (e.g., water) to minimize ultrasonic wave attenuation. A control means cooperates with the ultrasonic means to produce a map of the tube wall thickness in an inspection region

  4. Investigating the Implications of a Variable RBE on Proton Dose Fractionation Across a Clinical Pencil Beam Scanned Spread-Out Bragg Peak

    OpenAIRE

    Marshall, Thomas; Chaudhary, Pankaj; Michaelidesova, Anna; Vachelova, Jana; Davidkova, Marie; Vondracek, Vladimir; SCHETTINO, Giuseppe; Prise, Kevin

    2016-01-01

    Purpose: To investigate the clinical implications of a variable relative biological effectiveness (RBE) on proton dose fractionation. Using acute exposures, the current clinical adoption of a generic, constant cell killing RBE has been shown to underestimate the effect of the sharp increase in linear energy transfer (LET) in the distal regions of the spread-out Bragg peak (SOBP). However, experimental data for the impact of dose fractionation in such scenarios are still limited.Methods and Ma...

  5. Oxide inspecting/sorting concepts. Revision 2

    International Nuclear Information System (INIS)

    The purpose of this document is to summarize the preferred methods for inspecting and sorting plutonium and uranium oxides in preparation for future processing. A limited number of commercially available systems were investigated in preparation for selecting the preferred candidate(s). A complete listing and description of all the oxides to be processed can be located in ''Materials Disposition Acceptance Specifications for the Plutonium Immobilization Project'', document number PIP-98-047. For the purposes of this document, they will be referred to simply as oxides, unless there is a specific characteristic requiring further explanation. The physical transfer of the oxides from a convenience can into a standard oxide can will occur in the High Contamination section of the Unpackaging/Sorting glovebox. The degree of oxide inspecting and sorting performed will depend on the processing that will occur after Unpackaging/Sorting, on the known condition of the oxide when it is first received and the degree of confidence in its condition. The order in which the steps are performed and what occurs in the individual steps may vary depending on the method selected. For the purpose of organization and to help clarify what may occur in the individual steps, the following guidelines are proposed for the Unpackaging/Sorting glovebox. Sorting will involve the capture and removal of foreign particles and/or to detain hard lumps for additional processing in Crush and Grind. Part of the sorting stage will involve reducing workable lumps (de-lumping) into a smaller particle size in preparation for the sizing stage. Sizing will involve classifying/grading the oxide powder into a particle size that is acceptable for the next processing stage. It could involve some mild form of processing (screening, eTc.), but is not expected to include any sophisticated type of processing. Inspection refers to the inspection of the final product to ensure it meets the particle size requirements for

  6. The impact of instructions on aircraft visual inspection performance : a first look at the overall results.

    Energy Technology Data Exchange (ETDEWEB)

    Drury, Colin G. (State University of New York at Buffalo, Buffalo, NY); Spencer, Floyd Wayne; Wenner, Caren A.

    2003-07-01

    The purpose of this study was to investigate the impact of instructions on aircraft visual inspection performance and strategy. Forty-two inspectors from industry were asked to perform inspections of six areas of a Boeing 737. Six different instruction versions were developed for each inspection task, varying in the number and type of directed inspections. The amount of time spent inspecting, the number of calls made, and the number of the feedback calls detected all varied widely across the inspectors. However, inspectors who used instructions with a higher number of directed inspections referred to the instructions more often during and after the task, and found a higher percentage of a selected set of feedback cracks than inspectors using other instruction versions. This suggests that specific instructions can help overall inspection performance, not just performance on the defects specified. Further, instructions were shown to change the way an inspector approaches a task.

  7. Ultrasonic inspection in fabrication of thick-walled reactor components

    International Nuclear Information System (INIS)

    Statistical evaluation of failures of conventional pressure vessels - done for appraising failure probabilities of nuclear pressure vessels - shows that lots of defects are caused by cracks not being detected in pre-service inspection. Therefore the inspection in fabrication should be done with utmost accuracy. In Germany three time independent ultrasonic testing has been performed to objectify the results of inspection. A further possibility is to mechanize the scanning procedure. Principles or possible constructions are shown, and the advantages and disadvantages of this testing method are discussed. A combination of mechanized and manual testing might be a possible solution of the problem of in-fabrication inspections. The mechanized test will give the survey. A further investigation of the findings will be done by extensive manual testing. Advanced NDT-techniques for flaw analysis might substitute the manual tests in the future

  8. Ultrasonic inspection of inpile tubes

    International Nuclear Information System (INIS)

    The in-service inspection (ISI) of inpile tubes can be performed accurately and safely with a semiautomatic ultrasonic inspection system. The ultrasonic technique uses a set of multiple transducers to detect and size cracks, voids, and laminations radially and circumferentially. Welds are also inspected for defects. The system is designed to inspect stainless steel and Inconel tubes ranging from 53.8 mm (2.12 in.) to 101.6 mm (4 in.) inner diameter with wall thickness on the order of 5 mm. The inspection head contains seven transducers mounted in a surface-following device. Six angle-beam transducers generate shear waves in the tubes. Two of the six are oriented to detect circumferential cracks, and two detect axial cracks. Although each of these four transducers is used in the pulse-echo mode, they are oriented in aligned sets so pitch-catch operation is possible if desired. The remaining angle-beam transducers are angulated to detect flaws that are off axial or circumferential orientation. The seventh transducer is used for longitudinal inspection and detects and sizes laminar-type defects

  9. The 5-point Investigator's Global Assessment (IGA) Scale: A modified tool for evaluating plaque psoriasis severity in clinical trials

    NARCIS (Netherlands)

    Langley, R.G.; Feldman, S.R.; Nyirady, J.; Kerkhof, P.C.M. van de; Papavassilis, C.

    2015-01-01

    Abstract Background: To evaluate new psoriasis treatments, clinicians, regulators and pharmaceutical developers require well-accepted, clinically meaningful measures of disease severity. The Psoriasis Area and Severity Index (PASI) score is most widely used as a primary endpoint in clinical trials,

  10. Risk based inspection programmes; Risikobaserte inspeksjonsprogrammer

    Energy Technology Data Exchange (ETDEWEB)

    Haugland, Haakon

    1998-07-01

    Risk based inspection is a method of selecting which parts or components of an offshore installation should be inspected and when if the resources available for inspection is to be fully exploited. By inspecting the components involving the highest risk, an optimum risk reduction is achieved. The risk level is a function of fault probability and fault consequence.

  11. 刍议痕迹检验技术在勘查检验交通肇事案件现场中的作用%Discussion on the role of trace inspection technology in the scene investigation of traffic accident

    Institute of Scientific and Technical Information of China (English)

    由明文

    2011-01-01

    Over the years,when the technical staff using the trace inspection technology to inspect the traffic accident, they often only take into account the special test of the overall separation of traces and the tire prints to identify the vehicle,but seldom know that the other traces have special roles in determining the nature of the case and the direction of investigation.This paper,through a series of specific traffic accident,indicated that the trace inspection technology has a wide range of applications in the scene investigation of traffic accident,which has a positive meaning for the detection of traffic accident.%长期以来,技术人员在应用痕迹检验技术勘验和检验交通肇事案件时,往往只考虑到特殊痕迹检验中整体分离痕迹和轮胎印痕来认定肇事车辆,对于其他痕迹在确定案件的性质,侦查方向有着特殊作用却少有所知。本文通过一系列具体的交通肇事案件,说明整个痕迹检验技术在交通肇事案件现场中有着广泛应用,对交通肇事案件的侦破具有积极的意义。

  12. An investigation of general predictors for cognitive–behavioural therapy outcome for anxiety disorders in a routine clinical setting

    Science.gov (United States)

    Nielsen, Sara Kerstine Kaya; Vangkilde, Signe; Wolitzky-Taylor, Kate B; Daniel, Sarah Ingrid Franksdatter; Hageman, Ida

    2016-01-01

    Introduction Cognitive–behavioural therapy (CBT) is effective for treating anxiety disorders and is offered in most mental health services around the world. However, a relatively large number of patients with anxiety disorders do not benefit from CBT, experience relapses or drop out. Reliable predictors of treatment effects are lacking. The aim of this study is to investigate the predictive value of emotion regulation and attentional control for CBT outcome in a routine setting. Methods and analysis In this prospective and practice-based study, 112 patients with anxiety disorders referred for manual-based group CBT at two psychiatric outpatient clinics will be recruited. Emotion regulation, severity of anxiety and attentional control will be assessed with self-report measures and with an experimental computer-based attentional control task at baseline, post-treatment and at a 6-month follow-up. Emotion regulation will be measured with Difficulties in Emotion Regulation Questionnaire, severity of anxiety will be assessed with Beck Anxiety Inventory and attentional control will be measured with the self-report questionnaire, Attention Control Scale, and with an experimental computer-based attentional control task based on theory of visual attention. Data will be analysed using multilevel mixed-effects modelling. Ethics and dissemination The study is approved by the Danish National Ethical Board, the Department of Psychology Ethical Board, University of Copenhagen and by the Danish Data Protection Agency. Study findings will be disseminated through peer-reviewed journal publications and conference presentations. The Danish Committee System on Health Research Ethics has been notified about the project. Trial registration number NCT02638363. PMID:27016248

  13. 49 CFR Appendix A to Part 230 - Inspection Requirements

    Science.gov (United States)

    2010-10-01

    .... Inspection of brake cylinders for piston travel. 11. Inspection of foundation brake gear. 12. Inspection of... crossheads and guides. 16. Inspection of piston rods and fasteners. 17. Inspection of main, side, and...

  14. The investigation of lithium formate hydrate, sodium dithionate and N-methyl taurine as clinical EPR dosimeters

    International Nuclear Information System (INIS)

    Introduction: EPR-dosimetry using L-α-alanine is an established method for measuring high doses of ionizing radiation. However, since a minimum dose of approximately 4 Gy is required to achieve sufficient low uncertainties (1–2%) for clinical application, alternative dosimeter materials are being inquired. Lithium formate (LiFo) monohydrate has been studied by several groups and has revealed several promising properties in the low dose region (<4 Gy). The fading properties, however, are somewhat unpredictable, and depend on properties not yet fully uncovered. This paper reports the results from a study of lithium formate hydrate and N-methyl taurine as potential low dose EPR dosimeters. Methods and materials: Pellet shaped dosimeters of lithium formate monohydrate, lithium formate hydrate, sodium dithionate and N-methyl taurine were produced using a manual Weber press, L-α-alanine was obtained from Harwell dosimeters and irradiated using 60 kV and 6 MV X-ray beams, and Co-60 gamma-rays to a dose of 30 Gy and dose ranges of 0.5–100 Gy and 2–20 Gy respectively. The dosimeters were measured using an Electron Paramagnetic Resonance (EPR)-spectrometer. The detector responses for 6 MV and Co-60 radiation beams, the fading behaviors and signal shape in time were investigated. Results: Lithium formate monohydrate and lithium formate hydrate are apparently associated with near identical EPR-spectra (mainly one broad line), and the same spectrum arises for all radiation energies investigated. The shape of the EPR resonance remains constant with time, but the intensities decreases, and the fading is more prominent for the monohydrate than for the hydrate. The EPR resonance associated with N-methyl taurine is more complex than the resonance associated with LiFo and it changes with time, implying radical transitions and growth. Conclusions: The study showed that lithium formate hydrate is a strong candidate for EPR dosimetry with slightly better fading characteristics

  15. ROBOTIC TANK INSPECTION END EFFECTOR

    Energy Technology Data Exchange (ETDEWEB)

    Rachel Landry

    1999-10-01

    The objective of this contract between Oceaneering Space Systems (OSS) and the Department of Energy (DOE) was to provide a tool for the DOE to inspect the inside tank walls of underground radioactive waste storage tanks in their tank farms. Some of these tanks are suspected to have leaks, but the harsh nature of the environment within the tanks precludes human inspection of tank walls. As a result of these conditions only a few inspection methods can fulfill this task. Of the methods available, OSS chose to pursue Alternating Current Field Measurement (ACFM), because it does not require clean surfaces for inspection, nor any contact with the Surface being inspected, and introduces no extra by-products in the inspection process (no coupling fluids or residues are left behind). The tool produced by OSS is the Robotic Tank Inspection End Effector (RTIEE), which is initially deployed on the tip of the Light Duty Utility Arm (LDUA). The RTEE combines ACFM with a color video camera for both electromagnetic and visual inspection The complete package consists of an end effector, its corresponding electronics and software, and a user's manual to guide the operator through an inspection. The system has both coarse and fine inspection modes and allows the user to catalog defects and suspected areas of leakage in a database for further examination, which may lead to emptying the tank for repair, decommissioning, etc.. The following is an updated report to OSS document OSS-21100-7002, which was submitted in 1995. During the course of the contract, two related subtasks arose, the Wall and Coating Thickness Sensor and the Vacuum Scarifying and Sampling Tool Assembly. The first of these subtasks was intended to evaluate the corrosion and wall thinning of 55-gallon steel drums. The second was retrieved and characterized the waste material trapped inside the annulus region of the underground tanks on the DOE's tank farms. While these subtasks were derived from the original

  16. ROBOTIC TANK INSPECTION END EFFECTOR

    International Nuclear Information System (INIS)

    The objective of this contract between Oceaneering Space Systems (OSS) and the Department of Energy (DOE) was to provide a tool for the DOE to inspect the inside tank walls of underground radioactive waste storage tanks in their tank farms. Some of these tanks are suspected to have leaks, but the harsh nature of the environment within the tanks precludes human inspection of tank walls. As a result of these conditions only a few inspection methods can fulfill this task. Of the methods available, OSS chose to pursue Alternating Current Field Measurement (ACFM), because it does not require clean surfaces for inspection, nor any contact with the Surface being inspected, and introduces no extra by-products in the inspection process (no coupling fluids or residues are left behind). The tool produced by OSS is the Robotic Tank Inspection End Effector (RTIEE), which is initially deployed on the tip of the Light Duty Utility Arm (LDUA). The RTEE combines ACFM with a color video camera for both electromagnetic and visual inspection The complete package consists of an end effector, its corresponding electronics and software, and a user's manual to guide the operator through an inspection. The system has both coarse and fine inspection modes and allows the user to catalog defects and suspected areas of leakage in a database for further examination, which may lead to emptying the tank for repair, decommissioning, etc.. The following is an updated report to OSS document OSS-21100-7002, which was submitted in 1995. During the course of the contract, two related sub-tasks arose, the Wall and Coating Thickness Sensor and the Vacuum Scarifying and Sampling Tool Assembly. The first of these sub-tasks was intended to evaluate the corrosion and wall thinning of 55-gallon steel drums. The second was retrieved and characterized the waste material trapped inside the annulus region of the underground tanks on the DOE's tank farms. While these sub-tasks were derived from the original intent

  17. Infrared thermography inspection for monoblock divertor target in JT-60SA

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Shigetoshi, E-mail: nakamura.shigetoshi@jaea.go.jp; Sakurai, Shinji; Ozaki, Hidetsugu; Seki, Yohji; Yokoyama, Kenji; Sakasai, Akira; Tsuru, Daigo

    2014-10-15

    Highlights: • Infrared thermography inspection is modified to inspect JT-60SA divertor targets. • Infrared thermography inspection is effective to detect joining defects of targets. • Numerical analysis is in good agreement with inspection results of mock-up targets. • Database for setting screening criteria has been constructed by numerical analysis. - Abstract: Carbon fiber composite (CFC) monoblock divertor target is required for power handling in JT-60SA. Quality of the targets depends on a joining technology in manufacturing process. To inspect the quality of more than 900 target pieces, efficient non-destructive inspection is needed. An infrared thermography inspection (IR inspection), has been proposed by ITER and IRFM, where the quality between CFC and a cooling tube is examined by a use of transient thermal response at a rapid switch from hot to cold water flow. In JT-60SA divertor target, a screw tube will be employed to obtain high heat transfer efficiency with simple structure. Since the time response of the screw tube is much faster than that of smooth tube, it is required to confirm the feasibility of this IR inspection. Thus, the effect of joining defects on transient thermal response of the targets has been investigated experimentally by using the mock-up targets containing defects which are artificially made. It was found that the IR inspection can detect the defects. Moreover, screening criteria of IR inspection for acceptable monoblock target is discussed.

  18. Infrared thermography inspection for monoblock divertor target in JT-60SA

    International Nuclear Information System (INIS)

    Highlights: • Infrared thermography inspection is modified to inspect JT-60SA divertor targets. • Infrared thermography inspection is effective to detect joining defects of targets. • Numerical analysis is in good agreement with inspection results of mock-up targets. • Database for setting screening criteria has been constructed by numerical analysis. - Abstract: Carbon fiber composite (CFC) monoblock divertor target is required for power handling in JT-60SA. Quality of the targets depends on a joining technology in manufacturing process. To inspect the quality of more than 900 target pieces, efficient non-destructive inspection is needed. An infrared thermography inspection (IR inspection), has been proposed by ITER and IRFM, where the quality between CFC and a cooling tube is examined by a use of transient thermal response at a rapid switch from hot to cold water flow. In JT-60SA divertor target, a screw tube will be employed to obtain high heat transfer efficiency with simple structure. Since the time response of the screw tube is much faster than that of smooth tube, it is required to confirm the feasibility of this IR inspection. Thus, the effect of joining defects on transient thermal response of the targets has been investigated experimentally by using the mock-up targets containing defects which are artificially made. It was found that the IR inspection can detect the defects. Moreover, screening criteria of IR inspection for acceptable monoblock target is discussed

  19. OSE inspection of protection program operations field perspective of inspections

    International Nuclear Information System (INIS)

    Protection Program Operations includes three functional areas: Physical Protection Systems, Protective Forces, and System Performance Testing. The Office of Security Evaluations (OSE) inspects field offices in these areas by evaluating programs relative to Standards and Criteria and by performing a variety of exercises and other types of tests to assure protective systems are effective and maintained at a proper level to meet the defined threat. Their perception of the OSE inspections has been positive. The approach taken by ID, with key areas/activities emphasized, during each phase of the field inspection process is described in this report. The most important areas for field offices to concentrate are: inspection preparations through self-evaluation, improving communications, assigning knowledgeable trusted agents, increasing awareness of facility procedures and operations, and assuring daily validations of inspected areas. Emphasis is placed on striving for a balance in reporting both positive and negative findings, and for consistency between ratings and the importance of report findings. OSE efforts to develop improved rating methodologies are encouraged

  20. 我院门诊喹诺酮类药物临床应用调查%Investigation on Clinical Use of Quinolones in Outpatient Clinic

    Institute of Scientific and Technical Information of China (English)

    田雪莉; 周霞

    2011-01-01

    Objective To understand the use status of quinolone- related drugs in the outpatient clinic for standardizing rational drug use in clinic. Methods The prescriptions involving quinolone- related drugs in the outpatient clinic were extracted and statistically analyzed in aspects of disease category, age, drug variety and rationality of drug use. Results Quinolone medication accounted for 21.50% of all antibiotic uses in the outpatient clinic. 43.06% of quinolones were used for respiratory diseases. Among them, levofloxacin had the highest use frequency(48.79% ). Unreasonable prescriptions included the use of quinolones for the patients yomger than 18 years old and without clear diagnosis of infectious diseases. Conclusion Quinolones are commonly used in anti- infection treatment in the outpatient clinic. The use indicators are rationally grasped as a whole. But using quinolones in children still exists, which should be needed to pay attention. The dosage in different ages has no apparent difference. The medieation dose in elderly patients should be adjusted.%目的 了解医院门诊喹诺酮类药物的使用情况,规范临床合理用药.方法 抽取喹诺酮类药物的处方,从痛种、患者年龄、用药品种、用药合理性等方面进行统计分析.结果 喹诺酮类药物的使用占全部抗茵药物的21.50%,43.06%用于呼吸系统疾病,其中左氧氟沙星使用频率最高(占喹诺酮类的48.79%).不合理用药包括18岁以下儿童用药、无感染性疾病诊断用药等.结论 喹诺酮类药物在医院门诊抗感染治疗中比较常见,应用指征掌握基本合理,但仍存在儿童用药,应予以重视.不同年龄用量差异不明显,对老年患者用药应进行剂量调整.

  1. Restaurant Inspection Scores and Foodborne Disease

    OpenAIRE

    Jones, Timothy F.; Pavlin, Boris I; LaFleur, Bonnie J.; Ingram, L. Amanda; Schaffner, William

    2004-01-01

    Restaurants in the United States are regularly inspected by health departments, but few data exist regarding the effect of restaurant inspections on food safety. We examined statewide inspection records from January 1993 through April 2000. Data were available from 167,574 restaurant inspections. From 1993 to 2000, mean scores rose steadily from 80.2 to 83.8. Mean inspection scores of individual inspectors were 69–92. None of the 12 most commonly cited violations were critical food safety haz...

  2. Examination of the association between announced inspections and inspection scores.

    Science.gov (United States)

    Waters, A Blake; VanDerslice, James; Porucznik, Christina A; Kim, Jaewhan; DeLegge, Royal; Durrant, Lynne

    2013-09-01

    In 2010 the Salt Lake Valley Health Department conducted a pilot of an announced inspection program utilizing a randomized assignment of restaurants to an intervention group with announced inspections and a control group that remained on the usual schedule of unannounced inspections. After adjusting for food type, visible kitchen, outside quality assurance, season, and standardized inspector, significant reductions were found in the odds ratios of personal hygiene (adjusted odds ratios [aOR] = 0.11, p = .00) and equipment cleanliness (aOR = 0.19, p = .00) violations. In the models for the control group, none of the odds ratios were statistically different from one, indicating no change in the postintervention time period as compared to the preintervention period. PMID:24073484

  3. The Use of Per Session Clinical Assessment with Clients in a Mental Health Delivery System: An Investigation into How Clinical Mental Health Counseling Practicum Students and Practicum Instructors Use Routine Client Progress Feedback

    Science.gov (United States)

    Yates, Chad Michael

    2012-01-01

    The purpose of this study was to investigate how clinical mental health counseling practicum students and practicum instructors use per session assessment feedback with clients they served at a university counseling center. Per session assessment and feedback has been shown to increase the treatment outcomes that counselors achieve while treating…

  4. Investigation of the teaching cognition and capabilities of clinical advisers for masters degree level nursing specialty graduate students

    Directory of Open Access Journals (Sweden)

    Xiao-Lei Zhao

    2014-03-01

    Conclusion: Clinical advisers for nursing specialty graduate students in our survey were generally inexperienced with regarding to training and culturing nursing graduate students. These advisers were prepared for core teaching competency, but were not qualified to conduct scientific research. Based on these results, it would be beneficial to provide the clinical advisers more training on teaching cognition for graduate students and improve their competency to perform scientific research.

  5. Overlapping phenotypes - a clinical and magnetic resonance imaging investigation of schizotypy and pervasive developmental disorders in adolescents with cognitive impairment

    OpenAIRE

    Stanfield, Andrew C.

    2007-01-01

    Introduction: The neurobiological bases of pervasive developmental disorders (PDD) and schizotypy are not well established. In addition there are clinical overlaps between the two which can make diagnostic determination difficult. The primary aim of this thesis was to explore the relationship between PDD and schizotypy by examining their associated clinical and brain structural features in a group of cognitively impaired adolescents. Methods: 138 adolescents receiving special educational a...

  6. A Novel Glycinate-based Body Wash: Clinical Investigation Into Ultra-mildness, Effective Conditioning, and Improved Consumer Benefits

    OpenAIRE

    Regan, Jamie; Mollica, Leonel-Maximo; Ananthapadmanabhan, K. P.

    2013-01-01

    Objective: To assess the properties of a novel body wash containing the mild surfactant glycinate. Design: Biochemical and clinical assays. Setting: Research laboratories and clinical sites in the United States and Canada. Participants: Women 18 to 65 years of age (cleansing efficacy); male and female subjects 26 to 63 years of age with mild or moderate dryness and erythema (leg-controlled application test); subjects 5 to 65 years of age with mild-to-moderate eczema (eczema compatibility); an...

  7. Independent validation of ultrasonic inspection

    International Nuclear Information System (INIS)

    As a part of its inspection strategy for the Sizewell-B PWR station, the Central Electricity Generating Board (in part now Nuclear Electric) decided that the ultrasonic inspection procedures for the incredibility of failure components would be subjected to independent confirmation of their adequacy. The incorporation of validation into a large-scale inspection strategy was unique at the time (1982), indeed remains so today. The CEGB's general philosophy is one of diversity, redundancy and validation. In order to carry out independent validation of the specific procedures and ultrasonic operators to be used during the manufacture and in-service inspection of the reactor pressure vessel and steam plant components, the Inspection Validation Centre (IVC) has operated as a contractor to Nuclear Electric with special arrangements in place to guarantee independence. The setting-up and early methods of operation of IVC are briefly reviewed, the most recent operational experience summarized and the technical significance of the validations to date discussed. (author). 1 fig

  8. The performance of a target-controlled infusion of propofol in combination with remifentanil : A clinical investigation with two propofol formulations

    NARCIS (Netherlands)

    Wietasch, JKG; Scholz, M; Zinserling, J; Kiefer, N; Frenkel, C; Knufermann, P; Brauer, U; Hoeft, A

    2006-01-01

    Target-controlled infusion (TCI) incorporates the pharmacokinetic variables of an IV drug to facilitate safe and reliable administration. In this clinical study we investigated the performance of propofol TCI in combination with remifentanil. Fifty-four adult patients scheduled for general surgery l

  9. Clinical findings related to intramammary infections in meat-producing ewes

    OpenAIRE

    Maiara G. Blagitz; Fernando N. Souza; Camila F. Batista; Diniz, Soraia A.; Haddad, João Paulo A.; Nilson R. Benites; Melville, Priscilla A.; Alice M.M.P. Della Libera

    2013-01-01

    The aim of this study was to investigate the relationship between clinical findings and bacterial isolation in milk samples of meat-producing ewes. The study was conducted in 17 commercial flocks and 550 udder halves from suckling Santa Ines ewes. Initially, the clinical examination of the mammary glands and teats was performed by visual inspection and palpation of the teats and udder halves; then a scoring system was devised for all the findings. After that, the strip cup test and the Califo...

  10. Distillation columns inspection through gamma scanning

    International Nuclear Information System (INIS)

    The application of nuclear energy is very wide and it allows the saving of economic resources since the investigation of a certain process is carried out without stop the plant. The gamma scanning of oil crackingcolumns are practical examples, they allow to determine the hydraulic operation of the inspected columns. A source of Co-60 22mCi and a detector with a crystal of INa(TI) are used. This paper shows the results got from a profile carried out in a column distillation

  11. Improvement of foundation for inspection

    International Nuclear Information System (INIS)

    Japan Nuclear Energy Safety Organization has been carrying out improvement of inspection system for nuclear plants in Japan since 2003FY. The new inspection system was introduced into nuclear power plants in-2008FY. In this project, improvement of comprehensive plant performance assessment and management tool for the new inspection system are developed. In 2012FY, a trend analysis method of the plant performance was developed with reference to the IAEA literature. And the trend analysis was tried based on the results of the comprehensive plant performance assessment of all domestic plants except Fukushima-Daiichi Nuclear Power Station. In addition, the teaching materials for QMS training guideline were made. And improvement of a quality management system evaluation support tool was performed. (author)

  12. Autonomous underwater riser inspection tool

    Energy Technology Data Exchange (ETDEWEB)

    Camerini, Claudio; Marnet, Robson [Petrobras SA, (Brazil); Freitas, Miguel; Von der Weid, Jean Pierre [CPTI/PUC-Rio, Rio de Janeiro, (Brazil); Artigas Lander, Ricardo [EngeMOVI, Curitiba, (Brazil)

    2010-07-01

    The detection of damage on the riser is a serious concern for pipeline companies. Visual examinations by remotely operated vehicle (ROV) are presently carried out to detect the defects but this process has limitations and is expensive. This paper presents the development of a new tool to ensure autonomous underwater riser inspection (AURI) that uses the riser itself for guidance. The AURI, which is autonomous in terms of control and power supply, is equipped with several cameras that perform a complete visual inspection of the riser with 100 % coverage of the external surface of the riser. The paper presents the detailed characteristics of the first AURI prototype, describes its launching procedure and provides the preliminary test results from pool testing. The results showed that the AURI is a viable system for autonomous riser inspection. Offshore tests on riser pipelines are scheduled to be performed shortly.

  13. Intracardiac impedance as a method for ventricular volume monitoring - Investigation by a finite-element model and clinical data

    Science.gov (United States)

    Lippert, M.; Berdyshev, S.; Czygan, G.; Bocchiardo, M.; Hensel, B.

    2010-04-01

    A method for monitoring left ventricular (LV) volume changes of the human heart by intracardiac impedance measurement was developed. In order to model this method, we simulated the ventricular contraction using a finite-element model (FEM). The myocardium comprised three layers with anatomical fiber orientation. During excitation propagation contraction forces were applied, taking into account the myocardial elastic properties and the blood pressure time course. For a set of 21 contraction stages we calculated the intracardiac impedance Z between the right ventricular (RV) and LV leads for a set of common LV lead positions. The FEM results were compared to clinical data. Impedance and stroke volume were determined during overdrive pacing and end diastolic volume (EDV) at rest in 14 patients. All clinical EDV values were in the range of 147-394ml. Both the clinical data and the FEM in this volume range showed a linear correlation between admittance Y=1/Z and ventricular volume. For a quantitative comparison end diastolic impedance EDZ and the slope dY/dV were calculated. The model results across all LV lead positions were EDZ=0.16-1.2Ω, and dY/dV=3.3-21mS/ml, corresponding to clinical values of EDZ=0.14-1.46Ω and dY/dV=1-64mS/ml. In conclusion, the FEM resembled the clinical measurement data and serves as theoretical basis for ventricular volume monitoring via intracardiac impedance.

  14. Implementation of a Quality Management System in regulatory inspection activities

    International Nuclear Information System (INIS)

    The Institute for Radioprotection and Dosimetry - IRD -, of the Brazilian National Nuclear Energy Commission, CNEN, started in 2001, the implementation of a quality management system (SGQ), in the inspection, testing and calibration activities. The SGQ was an institutional guideline and is inserted in a larger system of management of the IRD started in 1999, with the adoption of the National Quality Award criteria - PNQ, within the Project for Excellence in Technological Research of Associacao Brasileira das Instituicoes de Pesquisas Tecnologicas - ABIPTI (Brazilian Association of Technological Research institutions). The proposed quality management system and adopted at the IRD was developed and implemented in accordance with the requirements of NBR ISO/IEC 17025 - General requirements for the competence of testing and calibration laboratories, and ISO/IEC 17020 - General criteria for operation of various types of bodies performing inspections. For regulatory inspection activities, the quality system was implemented on three program inspection services of radiological protection led, respectively, by clinics and hospitals that operate radiotherapy services; industries that use nuclear gauges in their control or productive processes and power reactor operators (CNAAA) - just the environmental part. It was formed a pioneering team of inspectors for standardizing the processes, procedures and starting the implementation of the system in the areas. This work describes the implementation process steps, including difficulties, learning and advantages of the adoption of a quality management system in inspection activities

  15. Integrated inspection of services for people with learning disabilities in Scotland: the way forward?

    Directory of Open Access Journals (Sweden)

    Martin Campbell

    2007-10-01

    Full Text Available Purpose: The article summarises the process and the results of the first, integrated inspection of managed care services for people with learning disabilities in Scotland. The multi-agency model used was developed to be congruent with the existing performance inspection models, used by single agency inspection. The inspection activities and main outcomes are described, and suggestions are made for improvements. Context of case: In 2006 an inspection model was devised to assess the quality of health, social services and education services for people with learning disabilities in one geographical area of Scotland, as a precursor to a programme of inspections nationally. The first joint, integrated inspection of all services for people with learning disabilities in Scotland took place in June 2006, and the report was published in March 2007. This was the first multi-agency inspection of its kind in the UK, and the first to involve carers and people with learning disabilities on the inspection team. Data sources: A number of data sources were used to check existing practice against agreed Quality Outcome indicators. Primary sources of data were social work records, health records, education records, staff surveys, carer surveys, interviews with staff, family carers and people with learning disabilities, and self evaluations completed by the services being inspected. Eleven different domains, each with sub-indicators were investigated. Case description: This paper summarises the process of an integrated, multi-agency inspection, how the inspection activities were conducted and the main findings of this inspection. Practical improvements to the process are suggested, and these may be of use to other services and inspectorates. Conclusions and discussion: The integrated inspection was a qualified success. Most major objectives were achieved. The sharing of data amongst inspection agencies, establishing the level of commitment to integrated inspection

  16. Evaluation of inservice inspection examinatiions

    International Nuclear Information System (INIS)

    In order to evaluate the effectiveness of Section 11, Division 1, ''Rules for Inservice Inspection of Nuclear Power Plant Components,'' of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code examinations, 26 inservice inspection (ISI) summary reports from 24 facilities were reviewed. It was found that these ASME Code examinations and tests are instrumental in revealing indications and defects in welds and plant components. In addition, this study uncovered that fact that some of the Section 11 requirements are apparently not clear and are misunderstood by some of the facilities. Also, the need for more stringent requirements was evaluated and some Code changes are recommended

  17. Evaluation of inservice inspection examinatiions

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, D.A.; Cook, J.F.

    1990-05-01

    In order to evaluate the effectiveness of Section 11, Division 1, ``Rules for Inservice Inspection of Nuclear Power Plant Components,`` of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code examinations, 26 inservice inspection (ISI) summary reports from 24 facilities were reviewed. It was found that these ASME Code examinations and tests are instrumental in revealing indications and defects in welds and plant components. In addition, this study uncovered that fact that some of the Section 11 requirements are apparently not clear and are misunderstood by some of the facilities. Also, the need for more stringent requirements was evaluated and some Code changes are recommended.

  18. Evaluation of inservice inspection examinatiions

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, D.A.; Cook, J.F.

    1990-05-01

    In order to evaluate the effectiveness of Section 11, Division 1, Rules for Inservice Inspection of Nuclear Power Plant Components,'' of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code examinations, 26 inservice inspection (ISI) summary reports from 24 facilities were reviewed. It was found that these ASME Code examinations and tests are instrumental in revealing indications and defects in welds and plant components. In addition, this study uncovered that fact that some of the Section 11 requirements are apparently not clear and are misunderstood by some of the facilities. Also, the need for more stringent requirements was evaluated and some Code changes are recommended.

  19. An Investigation About Attitude of Clinical Physicians in the Implementation of Telemedicine Technology in TUMS Hospitals 2003-2004

    Directory of Open Access Journals (Sweden)

    H Dargahi

    2005-05-01

    Full Text Available Background: This research have presented focuses upon the cultural side of managerial coordination and control as manifested in Telemedicine Technology. Specifically, the research seeks to analyze and determines the attitude of clinical physicians about the role of specific dimensions of organizational culture and organizational structure may have upon effective managerial coordination and control in Telemedicine Technology in TUMS hospitals. Materials and methods: We assessed the attitude of 82 clinical physicians in five randomly selected TUMS teaching hospitals in a mixed method of pooling Quantitative and Qualitative data using unstructured interview technique. Results: For successful telemedicine utilization, most of clinical physicians believed that we need organic organizations that have involved leadership, open and free communication of mistakes and success, desire to experiment with new ideas, support for continuing education, support for new things, clear rules to follow and acknowledge performance goals. Conclusion: The data indicate that organizational is most important to utilize successfur telemedicine technology.

  20. Reasoning with Linear Orders: Differential Parietal Cortex Activation in Sub-Clinical Depression. An fMRI Investigation in Sub-Clinical Depression and Controls

    OpenAIRE

    Hinton, Elanor C.; Wise, Richard G; Singh, Krish D.; Ulrich evon Hecker

    2015-01-01

    The capacity to learn new information and manipulate it for efficient retrieval has long been studied through reasoning paradigms, which also has applicability to the study of social behavior. Humans can learn about the linear order within groups using reasoning, and the success of such reasoning may vary according to affective state, such as depression. We investigated the neural basis of these latter findings using functional neuroimaging. Using BDI-II criteria, 14 non-depressed (ND) and 12...

  1. Planning Annual Shutdown Inspection for BFB Boiler

    OpenAIRE

    Sorsa, Tatu

    2014-01-01

    The goal of this thesis was to create an illustrative guidebook of annual inspection planning for BFB boiler to help power plant operator when planning of annual inspection is topical. This thesis was made for Andritz Oy and it is based on inspection reports and experiences of BFB boiler’s maintenance and inspection staff. In this thesis it is shown how to plan an annual inspection for BFB boiler and thesis gives good tools and hints for operator to manage inspection from the beginning ...

  2. Investigation on food inspection capacity of centers for disease control and prevention in Fujian province%福建省疾控机构食品检验能力现状调查

    Institute of Scientific and Technical Information of China (English)

    袁平; 郑奎城; 林仲; 何梓凯

    2013-01-01

    Objective To understand the food inspection capacity of centers for disease control and prevention (CDC) in Fujian province, promote the rational resource distribution and utilization, and provide a scientific basis for decision-making of health administrative departments. Methods The census was conducted on Fujian disease control institutions; data were collected through network platform. Results ①There was about 57 of food inspectors, account for 7% . The average of food inspectors with high Technical titles was 10, less than 6 (5. 78) , less than 1 (0. 72) and with master's degree or above was 7 , less than 3 (2. 67) , 0 (0. 09 ) respectively. There was about 0. 7 people with senior titles and about 0. 42 of full-time quality control on average at county level. ② The approval ratio of CMA accreditation was 67. 0% and the food inspection parameter compliance rate was 100. 0% , 77. 8% and 18. 5% , respectively at different levels. ③ 93. 9% equipment was in the unit price of 100 thousand or less in county CDC. The instruments of class A and class B in country institutions were inadequate. 46. 2% of the laboratories failed to meet the area requirements according to the guidance, either. Conclusion There are lots of deficiencies in institutes of CDC in Fujian Province, such as food inspectors' qualifications, inspection capacity, advanced equipment, infrastructure and so on, especially at county level.%目的 了解福建省疾控机构食品检验能力,促进食品检验资源的合理配置和使用,为卫生行政部门的食品安全管理决策提供科学依据.方法 采用网络平台方式收集福建省疾控机构食品检验能力相关数据信息.结果①专职食品检验人员57名,占从事食品检验人员数的7%;食品检验人员具备高级职称者在福建省级、市级、县级疾控机构中分别平均为10人、不足6人(5.78人)、不足1人(0.72人);食品检验人员研究生及以上学历者在福建省级、市级

  3. Pathogenesis of acute rheumatic fever and rheumatic heart disease: evasive after half a century of clinical, epidemiological, and laboratory investigation

    OpenAIRE

    Kaplan, E. L.

    2005-01-01

    Rheumatic fever and rheumatic heart disease continue to be a problem for medical and public health communities—the fact that penicillin has failed to eradicate this disease process is irrefutable proof of the need for more laboratory, epidemiological, and clinical research

  4. Careless and Random Responding on Clinical and Research Measures in the Addictions: A Concerning Problem and Investigation of Their Detection

    Science.gov (United States)

    Meyer, Joseph F.; Faust, Kyle A.; Faust, David; Baker, Aaron M.; Cook, Nathan E.

    2013-01-01

    Even when relatively infrequent, careless and random responding (C/RR) can have robust effects on individual and group data and thereby distort clinical evaluations and research outcomes. Given such potential adverse impacts and the broad use of self-report measures when appraising addictions and addictive behavior, the detection of C/RR can…

  5. Cost-Benefit Assessment of Inspection and Repair Planning for Ship Structures Considering Corrosion Model Uncertainty

    Institute of Scientific and Technical Information of China (English)

    LI Dian-qing; TANG Wen-yong; ZHANG Sheng-kun

    2005-01-01

    Owing to high costs and unnecessary inspections necessitated by the traditional inspection planning for ship structures, the risk-based inspection and repair planning should be investigated for the most cost-effective inspection. This paper aims to propose a cost-benefit assessment model of risk-based inspection and repair planning for ship structures subjected to corrosion deterioration. Then, the benefit-cost ratio is taken to be an index for the selection of the optimal inspection and repair strategy. The planning problem is formulated as an optimization problem where the benefit-cost ratio for the expected lifetime is maximized with a constraint on the minimum acceptable reliability index. To account for the effect of corrosion model uncertainty on the cost-benefit assessment, two corrosion models, namely, Paik's model and Guedes Soares' model, are adopted for analysis. A numerical example is presented to illustrate the proposed method. Sensitivity studies are also provided. The results indicate that the proposed method of risk-based cost-benefit analysis can effectively integrate the economy with reliability of the inspection and repair planning. A balance can be achieved between the risk cost and total expected inspection and repair costs with the proposed method, which is very effective in selecting the optimal inspection and repair strategy. It is pointed out that the corrosion model uncertainty and parametric uncertainty have a significant impact on the cost-benefit assessment of inspection and repair planning.

  6. SOME THEORETICAL ASPECTS OF COMPLEX CLINICAL-PSYCHOLOGICAL INVESTIGATION OF PATIENTS WITH AUTOIMMUNE LIVER DISEASES IN CIRRHOTIC STAGE BEFORE LIVER TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    O. A. Gerasimova

    2010-01-01

    Full Text Available This article presents preliminary results of complex clinical-psychological investigation of patients with autoim- mune liver diseases with cirrhosis waiting for liver transplant. The data discussed defense role of anxiety com- bined with other emotional affective disorders, psychological mechanisms in combination with coping strategies of stress-overcoming behavior in the state of disease and their involvement in formation of the clinical picture of the disease. It considers the need for differential diagnosis of the pathology using modern experimental- psychological methods in connection with further building of psychological aid to patients with autoimmune liver diseases. 

  7. Investigation of the efficacy of Tarantula cubensis extract (Theranekron D6) in the treatment of subclinical and clinical mastitis in dairy cows

    OpenAIRE

    Gürbulak, Kutlay; AKÇAY, Aytaç; GÜMÜŞSOY, Kadir Semih; SIST, Birgit

    2014-01-01

    The aim of this study was to investigate the effects of the use of Theranekron alone or in combination with intramammary antibiotic therapy for the treatment of subclinical and clinical mastitis on the recovery rate from mastitis. The study material was composed of 177 mammary lobes of 63 Holstein cows with subclinical (groups S1 and S2) and clinical mastitis (groups C1, C2, C3, and C4). In all of the treatment groups, excluding group S2, the California mastitis test scores were determined to...

  8. Inspection of environmental conditions 1991

    International Nuclear Information System (INIS)

    A comprehensive survey of environmentally protective activities (including inspections or surveillance, planning, the giving of guidelines and approvals) carried out by Danish local authorities and municipalities on pollutive/environmental conditions related to public services, companies and agriculture during 1991. Administrative details are given. The survey is based on the accounts of the inspections produced by the individual authorities. Information is given on the extent of these projects, the nature of the activities involved and the evaluation of them made by the (Danish) National Agency for Environmental Protection. In the appendices data is presented on the percentage of companies visited, the amounts of oil and chemical industrial wastes, the visited farms, the average number of domestic animals held, the nitrate content of drinking water in a number of specified waterworks, the number of objects of inspection, the number of enforcements in relation to the number of inspections and organic substances discharged from sewage works. Other related data, for example on the management of wastes, illustrate the detailed text. (AB)

  9. Artificial Intelligence Assists Ultrasonic Inspection

    Science.gov (United States)

    Schaefer, Lloyd A.; Willenberg, James D.

    1992-01-01

    Subtle indications of flaws extracted from ultrasonic waveforms. Ultrasonic-inspection system uses artificial intelligence to help in identification of hidden flaws in electron-beam-welded castings. System involves application of flaw-classification logic to analysis of ultrasonic waveforms.

  10. Nuclear pipework - welding and inspection

    International Nuclear Information System (INIS)

    The subject is covered in sections: introduction emphasizing need for perfection in welding nuclear pipework; detailed procedures (British Standards, TIG welding, automatic orbital TIG welding machines); unacceptable faults; improving performance (higher quality of commercially-available grades of stainless steels); auto welding; testing 'nuclear' welding; safe working (standard specifications, radiography); training; radiographic techniques; radiographic procedures; other inspections. (U.K.)

  11. FAA Fluorescent Penetrant Laboratory Inspections

    Energy Technology Data Exchange (ETDEWEB)

    WINDES,CONNOR L.; MOORE,DAVID G.

    2000-08-02

    The Federal Aviation Administration Airworthiness Assurance NDI Validation Center currently assesses the capability of various non-destructive inspection (NDI) methods used for analyzing aircraft components. The focus of one such exercise is to evaluate the sensitivity of fluorescent liquid penetrant inspection. A baseline procedure using the water-washable fluorescent penetrant method defines a foundation for comparing the brightness of low cycle fatigue cracks in titanium test panels. The analysis of deviations in the baseline procedure will determine an acceptable range of operation for the steps in the inspection process. The data also gives insight into the depth of each crack and which step(s) of the inspection process most affect penetrant sensitivities. A set of six low cycle fatigue cracks produced in 6.35-mm thick Ti-6Al-4V specimens was used to conduct the experiments to produce sensitivity data. The results will document the consistency of the crack readings and compare previous experiments to find the best parameters for water-washable penetrant.

  12. Pressure vessel inspection criteria based on fitness-for-purpose assessment

    International Nuclear Information System (INIS)

    The paper on pressure vessel inspection investigates the methodology required to establish an inspection strategy consistent with fracture mechanics analysis, i.e. to define allowable flaw sizes based on location within the vessel. The methodology is demonstrated using a sample problem for a typical pressurised water reactor pressure vessel, and shows the impact of certain assumptions on the inspection strategy. The results indicate that the flaw size varies with the shape of the assumed residual stress field and the through-thickness location. Also in general, the fracture mechanics evaluation allows flaws much larger than are allowed by the inspection acceptance criteria. (UK)

  13. Application of ultrasonic phased array technique for inspection of stud bolts in nuclear reactor vessel

    International Nuclear Information System (INIS)

    The stud bolt is one of crucial parts for safety of reactor vessels in nuclear power plants. Cracks initiation and propagation were reported in stud bolts using closure of reactor vessel and head. Stud bolts are inspected by ultrasonic technique during overhaul periodically for the prevention of stud bolt failure and radioactive leakage from nuclear reactor. In conventional ultrasonic testing for inspection of stud bolts, crack was detected by using shadow effect. It take too much time to inspect stud bolt by using conventional ultrasonic technique. In addition, there were numerous spurious signal reflected from every thread. In this study, the advanced ultrasonic phased array technique was introduced for inspect stud bolts. The phased array technique provide fast inspection and high detectability of defects. There are sector scanning and linear scanning method in phased array technique, and these scanning methods were applied to inspect stud bolt and detectability was investigated.

  14. The investigation of Optical Coherence Tomography as a clinical tool to determine the extent of Molar Incisor Hypomineralisation (MIH) Lesions

    OpenAIRE

    Al-Azri, K. M. H.

    2015-01-01

    Molar incisor hypomineralisation (MIH) is associated with abnormal mineralisation of enamel during tooth development. It is probably related to systemic upset during this stage of enamel formation. Diagnosing this condition at an early stage is essential in its management, due to complications such as hypersensitivity, post-eruptive breakdown and rapid carious progression in the affected teeth. The current diagnostic measures are clinical visual examination with the aid of indices which are u...

  15. An Investigation About Attitude of Clinical Physicians in the Implementation of Telemedicine Technology in TUMS Hospitals 2003-2004

    OpenAIRE

    H Dargahi

    2005-01-01

    Background: This research have presented focuses upon the cultural side of managerial coordination and control as manifested in Telemedicine Technology. Specifically, the research seeks to analyze and determines the attitude of clinical physicians about the role of specific dimensions of organizational culture and organizational structure may have upon effective managerial coordination and control in Telemedicine Technology in TUMS hospitals. Materials and methods: We assessed the attitude of...

  16. Harsh discipline, childhood sexual assault, and MAOA genotype: An investigation of main and interactive effects on diverse clinical externalizing outcomes

    OpenAIRE

    Derringer, Jaime; Krueger, Robert F.; Irons, Daniel E.; IACONO, WILLIAM G.

    2010-01-01

    We studied the impact of MAOA genotype, childhood sexual assault, and harsh discipline on clinical externalizing symptoms (substance problems, adult antisocial behavior, and conduct disorder). Participants were 841 individual twins from the Minnesota Twin Family Study assessed through age 25. MAOA genotype was not associated with differences in any phenotype, nor was there a significant interaction between MAOA and harsh discipline for any phenotype or a significant interaction between MAOA a...

  17. Investigation the quality of life and its relation with clinical and demographic characteristics in women with breast cancer under chemotherapy

    OpenAIRE

    Amir Musarezaie; Tahere Momeni Ghale Ghasemi; Homayoon Naji Esfahani

    2012-01-01

    Background: This study was performed to examine quality of life′s dimensions and its relationship with some clinical and demographic characteristics on women with breast cancer under chemotherapy referred to the oncology hospital, Isfahan University of medical sciences, Iran. Methods: This Cross sectional study was conducted among 330 a descriptive-analytic one breast cancer patients with simple sampling methodology. Data collection instrument included a questionnaire contains 2 parts (cl...

  18. GNOSIS: Guidelines for neuro-oncology: Standards for investigational studies—reporting of phase 1 and phase 2 clinical trials

    Science.gov (United States)

    Chang, Susan M.; Reynolds, Sharon L.; Butowski, Nicholas; Lamborn, Kathleen R.; Buckner, Jan C.; Kaplan, Richard S.; Bigner, Darell D.

    2005-01-01

    We present guidelines to standardize the reporting of phase 1 and phase 2 neuro-oncology trials. The guidelines are also intended to assist with accurate interpretation of results from these trials, to facilitate the peer-review process, and to expedite the publication of important and accurate manuscripts. Our guidelines are summarized in a checklist format that can be used as a framework from which to construct a phase 1 or 2 clinical trial. PMID:16212807

  19. Detailed molecular and clinical investigation of a child with a partial deletion of chromosome 11 (Jacobsen syndrome)

    OpenAIRE

    Peitsidis Panagiotis; Thomaidis Loretta; Papoulidis Ioannis; Louizou Eirini; Kefalas Konstantinos; Neroutsou Rosita; Orru Sandro; Manolakos Emmanouil; Sotiriou Sotirios; Kitsos George; Tsoplou Panagiota; Petersen Michael B; Metaxotou Aikaterini

    2009-01-01

    Abstract Background Jacobsen syndrome (JBS) is a rare chromosomal disorder leading to multiple physical and mental impairment. This syndrome is caused by a partial deletion of chromosome 11, especially subband 11q24.1 has been proven to be involved. Clinical cases may easily escape diagnosis, however pancytopenia or thrombocytopenia may be indicative for JBS. Results We report a 7.5 years old boy presenting with speech development delay, hearing impairment and abnormal platelet function. High...

  20. Clinical and Pathological Investigation on Turkey Diseases in North-central City of Jos, Nigeria, 2009-2014

    OpenAIRE

    Olatunde Babatunde Akanbi; Christiana Ibironke Odita; Philip Adeokemola Okewole; Christopher Jerry Bot; Adebowale Obalisa; Ezekiel Gyang Pam; Dakyahas John; Johnson Shallmizhili; Gabriel Ijale; Bulus Alim

    2015-01-01

    Information on turkey production and disease is rare in Nigeria, possibly because turkeys are seldom raised commercially. Also, turkeys require intensive husbandry and health care after hatching, which backyard poultry producers hardly provided especially, when raised in a disease endemic environment. In an attempt to document the diseases militating against turkey production in Nigeria, clinical and necropsy records were reviewed from veterinary practices in Jos and the Central Diagnostic La...

  1. Myelin Abnormalities in Schizophrenia: Insights from Proteomic Investigations of Post-Mortem Schizophrenia and Pre-Clinical Animal Models

    OpenAIRE

    Farrelly, Lorna

    2014-01-01

    Accumulating evidence from epidemiologic and clinical findings report that both exposure to prenatal inflammation and prenatal iron deficiency significantly increase the risk of developing Schizophrenia in the offspring. Abnormalities in myelin are the most robust neuropathological findings in post-mortem human Schizophrenia, however the exact mechanisms at the protein and pathway levels owing to the myelin deficits are largely unknown. Animal models offer a fruitful approach to study the ...

  2. CAT -- computer aided testing for resonant inspection

    International Nuclear Information System (INIS)

    Application of computer technology relates to inspection and quality control. The computer aided testing (CAT) can be used to analyze various NDT technologies, such as eddy current, ultrasonics, and resonant inspection

  3. Allegheny County Housing and Community Environment Inspections

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Residential housing inspections and inspections in response to complaints for community environment problems, such as open vacant structures, vacant lots with...

  4. Automated Ply Inspection (API) for AFP Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Automated Ply Inspection (API) system autonomously inspects layups created by high speed automated fiber placement (AFP) machines. API comprises a high accuracy...

  5. Tecnology Development for Robotic Surface Inspection

    Science.gov (United States)

    Volpe, Richard; Balaram, J. Bob

    1994-01-01

    For the past three years at JPL, NASA has been sponsoring the Remote Surface Inspection Project to develop the technology needed for doing periodic and on-demand inspection of space borne platforms, in particular Space Station Freedom.

  6. Investigating Antibiotic Resistance in Pseudomonas Aeruginosa Strains Isolated from Various Clinical Specimens of Patients Referring to Hospitals in Yazd

    Directory of Open Access Journals (Sweden)

    M Kiani

    2015-02-01

    Full Text Available Introduction: Antibiotic resistance in Pseudomonas aeruginosa has become a worldwide problem, and is leading to multi-drug resistance (MDR: Multiple drug resistance. Therefore, this study aimed to determine the antibiotic strain patterns of Pseudomonas aeruginosa isolated from various clinical specimens of patients in hospitals in Yazd. Methods: In this descriptive cross- sectional study, 90 isolates of pseudomonas aeruginosa derived from different clinical samples was transferred to the microbiology lab of Shahid Sadoughi University of Medical Sciences in Yazd in 2013. Conventional biochemical tests were utilized to confirm the presence of bacteria, and then antibiotic resistance pattern was determined using standard disk diffusion (Kirby - Bauer method according to the CLSI guideline. Results: Out of 90 isolates of Pseudomonas aeruginosa isolated from various clinical samples, burn wound specimens had the most antibiotic-resistant pattern. As a matter of fact, all of 28 strains isolated from burn wounds were MDR. Ceftazidime involved the most resistant antibiotic (56%, whereas ciprofloxacin was the least resistant one (44.4%, and 66.6% of the isolates were detected as multi-drug resistant. Conclusion: The prevalence of MDR Pseudomans aeruginosa in the present study was high. As ceftazidime, Ertapenem, and meropenem had effective anti Pseudomonal activity against MDR Pseudomans aeruginosa (in this study increased resistance to these antibiotics was observed, it is necessary to evaluate antibiotic susceptibility as well as to determine antibiotic pattern prior to starting the treatment in order to prevent antibiotic-resistant strains.

  7. A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project.

    Science.gov (United States)

    Koike, Shinsuke; Takano, Yosuke; Iwashiro, Norichika; Satomura, Yoshihiro; Suga, Motomu; Nagai, Tatsuya; Natsubori, Tatsunobu; Tada, Mariko; Nishimura, Yukika; Yamasaki, Syudo; Takizawa, Ryu; Yahata, Noriaki; Araki, Tsuyoshi; Yamasue, Hidenori; Kasai, Kiyoto

    2013-01-01

    Longitudinal clinical investigations and biological measurements have determined not only progressive brain volumetric and functional changes especially around the onset of psychosis but also the abnormality of developmental pathways based on gene-environment interaction model. However, these studies have contributed little to clinical decisions on their diagnosis and therapeutic choices because of subtle differences between patients and healthy controls. A multi-modal approach may resolve this limitation and is favorable to explore the pathophysiology of psychosis. The integrative neuroimaging studies for schizophrenia targeting early intervention and prevention (IN-STEP) is a research project aimed at exploring the pathophysiological features of the onset of psychosis and investigating possible predictive biomarkers for the clinical treatment of psychosis. Since 2008, we have adopted blood sampling, neurocognitive batteries, neurophysiological assessment, structural imaging, and functional imaging longitudinally for help-seeking ultra-high-risk (UHR) individuals and patients with first-episode psychosis (FEP). Here, we intend to introduce the IN-STEP research study protocol and present preliminary clinical findings. Thirty-seven UHR individuals and 30 patients with FEP participated in this study. Six months later, there was no difference in objective and subjective scores between the groups, which suggests that young people having symptoms and functional deficits should be cared for regardless of their history of psychosis according to their clinical stages. The rate of transition to psychosis was 7.1%, 8.0%, and 35.3% (at 6, 12, and 24months, respectively). Through this research project, we expect to clarify the pathophysiological features around the onset of psychosis and improve the prognosis of psychosis through clinical application. PMID:23219075

  8. Experimental Stress Analysis at Railway Inspection Pit

    Directory of Open Access Journals (Sweden)

    Nicuşor Laurentiu Zaharia

    2008-10-01

    Full Text Available Railway inspection pits are used in railway halls. The purpose of inspection pits is to allow the working under the vehicle. Inspection pits can be found in locomotive depots, factories etc. The new design for a inspection pit in a railway hall involve tests in purpose of homologations the railway infrastructure. Before the homologation committee meeting, tests are made; after the test, a testing report is made which it will be part at homologation documents.

  9. The use of risk indicators for establishing inspection and control priorities

    International Nuclear Information System (INIS)

    Risk-informed approach used to support decision-making related to in-service inspections was considered in order to identify ways for establishing inspection and control priorities. The in-service inspection of piping in the Ignalina NPP has been selected as the object for research application, The inspection process studied was modelled using the integration of deterministic and probabilistic analysis methods, In order to optimize the inspection process, the focus was set on the highest risk measured as the conditional core damage frequency, It was produced by quantitatively estimated probabilities of different degradation states and conditional failure consequence probabilities, Comprehensive databases for calculation of such indicators (measures) were collected and analyzed, The failure statistical analysis as well as the evaluation of inspection efficiency expressed by the probability of defect detection was also used, The databases were further investigated with a closer attention to the data variation and comparison of risk measures using the developed software, The developed software was used to perform and administrate all the risk evaluations and ensure the possibilities to compare different options and perform sensitivity analysis, The risk measures helped to define an adequate inspection program and to focus inspections on the more important locations of the study systems, This approach allowed an optimisation of the inspection program while the probabilistic and fundamental deterministic safety requirements were maintained, The approaches to define an acceptable level of the inspection program were also considered. These approaches to define an acceptable risk were considered together with the means to reduce the number of inspection sites and the cumulative radiation exposure to the NPP inspection personnel with a reduction of overall risk, The investigated issues provided a good basis for drawing conclusions about the inspection priorities, to

  10. Licensee contractor and vendor inspection status report

    International Nuclear Information System (INIS)

    This periodical covers the results of inspections performed by the NRC's Vendor Inspection Branch that have been distributed to the inspected organizations during the period form January 1994 through March 1994. A list of selected bulletins and information notices involving vendor issues and copies of pertinent correspondence involving vendor issues are also included in this periodical

  11. Generator acceptance test and inspection report

    International Nuclear Information System (INIS)

    This Acceptance Test Report(ATR) is the completed testing and inspection of the new portable generator. The testing and inspection is to verify that the generator provided by the vendor meets the requirements of specification WHC-S-0252, Revision 2. Attached is various other documentation to support the inspection and testing

  12. 42 CFR 73.18 - Inspections.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Inspections. 73.18 Section 73.18 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES QUARANTINE, INSPECTION, LICENSING SELECT AGENTS AND TOXINS § 73.18 Inspections. (a) Without prior notification, the HHS Secretary, shall...

  13. 9 CFR 354.10 - Inspection service.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Inspection service. 354.10 Section 354.10 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Basis of Service § 354.10...

  14. Modelling in Optimal Inspection and Repair

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Rackwitz, R.; Faber, M.H.;

    1991-01-01

    A model for reliability based optimal inspection and repair strategies is described. The total expected costs in the lifetime is minimized with the number of inspections, the inspection times and efforts, the repair crack size limit and a design parameter as optimization variables. The equivalenc...

  15. Innovative Sensors for Pipeline Crawlers: Rotating Permanent Magnet Inspection

    Energy Technology Data Exchange (ETDEWEB)

    J. Bruce Nestleroth; Richard J. Davis; Stephanie Flamberg

    2006-09-30

    Internal inspection of pipelines is an important tool for ensuring safe and reliable delivery of fossil energy products. Current inspection systems that are propelled through the pipeline by the product flow cannot be used to inspect all pipelines because of the various physical barriers they may encounter. To facilitate inspection of these ''unpiggable'' pipelines, recent inspection development efforts have focused on a new generation of powered inspection platforms that are able to crawl slowly inside a pipeline and can maneuver past the physical barriers that limit internal inspection applicability, such as bore restrictions, low product flow rate, and low pressure. The first step in this research was to review existing inspection technologies for applicability and compatibility with crawler systems. Most existing inspection technologies, including magnetic flux leakage and ultrasonic methods, had significant implementation limitations including mass, physical size, inspection energy coupling requirements and technology maturity. The remote field technique was the most promising but power consumption was high and anomaly signals were low requiring sensitive detectors and electronics. After reviewing each inspection technology, it was decided to investigate the potential for a new inspection method. The new inspection method takes advantage of advances in permanent magnet strength, along with their wide availability and low cost. Called rotating permanent magnet inspection (RPMI), this patent pending technology employs pairs of permanent magnets rotating around the central axis of a cylinder to induce high current densities in the material under inspection. Anomalies and wall thickness variations are detected with an array of sensors that measure local changes in the magnetic field produced by the induced current flowing in the material. This inspection method is an alternative to the common concentric coil remote field technique that induces

  16. 24 CFR 3282.362 - Production Inspection Primary Inspection Agencies (IPIAs).

    Science.gov (United States)

    2010-04-01

    ... section and of § 3280.5 of chapter XX of 24 CFR. The data plate shall be furnished by the manufacturer and... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Production Inspection Primary... REGULATIONS Primary Inspection Agencies § 3282.362 Production Inspection Primary Inspection Agencies...

  17. Phased arrays: inline flow line hub inspection using phased arrays

    NARCIS (Netherlands)

    Bloom, J.G.P.; Chougrani, K.; Rundberg, H.; Oldenziel, G.; Deleye, X.; Martina, Q.

    2011-01-01

    The feasibility of the inspection of flow line hubs using the phased array technique was investigated to determine the surface area of the seal area degraded by corrosion. A clean model of the hub was simulated to gain insight into the geometrical echoes and to determine the area covered by the ultr

  18. Novel sensors for food inspection modelling, fabrication and experimentation

    CERN Document Server

    Abdul Rahman, Mohd Syaifudin; Yu, Pak-Lam

    2014-01-01

    This book addresses presents recent developments of novel planar interdigital sensors for food inspection. It covers the fundamentals of sensors, their design, modelling and simulations, fabrications, characterizations, experimental investigations and analyses. This book will be useful for the engineers and researchers especially higher undergraduate, postgraduate students as well as practitioners working on the development of Electromagnetic Sensors.

  19. The data correction algorithms in 60Co train inspection system

    International Nuclear Information System (INIS)

    Because of the physical characteristics of the 60Co train inspection system and the application of high-speed data collection system based on current integral, the original images have been distorted in a certain degree. Authors investigate into the reasons why the distortion comes into being, and accordingly present the data correction algorithm

  20. Investigation of the Relationship Between Clinical and EEG Findings of Photosensitive Epilepsy and GABA Receptor Alpha 1 Subunit (GABRA1) Gene Mutations

    OpenAIRE

    Yavuz, E.N.; Demirkan, A.; Moen, S.; Ozdemir, O.; Catal, S.; Bebek, N.; Ozbek, U; Baykan, B.

    2011-01-01

    Objective: Although photosensitive epilepsy (PE) is commonly observed, its pathophysiology has not been clarified yet. However, relevant literature indicates that genetic factors play an important role. Our aim was to investigate whether there is a relationship between the clinical and electroencephalographic (EEG) features and the possible mutations/polymorphisms in the GABA receptor alpha 1 subunit (GABRA1) gene in patients with PE by scanning this gene. Methods: 54 patients diagnosed as ha...

  1. A factor analytic investigation of the Tripartite model of affect in a clinical sample of young Australians

    Directory of Open Access Journals (Sweden)

    Cosgrave Elizabeth M

    2008-09-01

    Full Text Available Abstract Background The Mood and Anxiety Symptom Questionnaire (MASQ was designed to specifically measure the Tripartite model of affect and is proposed to offer a delineation between the core components of anxiety and depression. Factor analytic data from adult clinical samples has shown mixed results; however no studies employing confirmatory factor analysis (CFA have supported the predicted structure of distinct Depression, Anxiety and General Distress factors. The Tripartite model has not been validated in a clinical sample of older adolescents and young adults. The aim of the present study was to examine the validity of the Tripartite model using scale-level data from the MASQ and correlational and confirmatory factor analysis techniques. Methods 137 young people (M = 17.78, SD = 2.63 referred to a specialist mental health service for adolescents and young adults completed the MASQ and diagnostic interview. Results All MASQ scales were highly inter-correlated, with the lowest correlation between the depression- and anxiety-specific scales (r = .59. This pattern of correlations was observed for all participants rating for an Axis-I disorder but not for participants without a current disorder (r = .18. Confirmatory factor analyses were conducted to evaluate the model fit of a number of solutions. The predicted Tripartite structure was not supported. A 2-factor model demonstrated superior model fit and parsimony compared to 1- or 3-factor models. These broad factors represented Depression and Anxiety and were highly correlated (r = .88. Conclusion The present data lend support to the notion that the Tripartite model does not adequately explain the relationship between anxiety and depression in all clinical populations. Indeed, in the present study this model was found to be inappropriate for a help-seeking community sample of older adolescents and young adults.

  2. Rotation pain as a symptom in the examination of the lame horse - Pathomorphologic, radiologic and clinical investigations

    International Nuclear Information System (INIS)

    An additional and important adjunct to the clinical examination of lameness is the evaluation of 'rotation-pain'. The provocation of pain in the digital joints can be devided into three types of manipulations: Rotation, turning and circle tests. ''Rotational pain'' is not necessarily a symptom of navicular disease. The most common causes of rotational pain are radiologically visible exostosis of the coffin and or pasternjoint. A special technique to radiograph the border exostosis, especially of the coffin joint, at angles of 45° and 315° is described

  3. Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation

    OpenAIRE

    Dennis BB; Samaan MC; Bawor M; Paul J; Plater C; Pare G; Worster A; Varenbut M; Daiter J; Marsh DC; Desai D; Thabane L; Samaan Z

    2014-01-01

    Brittany B Dennis,1 M Constantine Samaan,2 Monica Bawor,3 James Paul,4 Carolyn Plater,5 Guillaume Pare,1 Andrew Worster,6 Michael Varenbut,5 Jeff Daiter,5 David C Marsh,5,7 Dipika Desai,8 Lehana Thabane,1,9,10 Zainab Samaan1,8,11 1Department of Clinical Epidemiology and Biostatistics, 2Department of Pediatrics, Division of Pediatric Endocrinology, 3McMaster Integrative Neuroscience Discovery and Study Program, 4Department of Anesthesia, McMaster University, Hamilton, 5Ontario Addiction...

  4. Metabolic syndrome in white European men presenting for primary couple's infertility: investigation of the clinical and reproductive burden.

    Science.gov (United States)

    Ventimiglia, E; Capogrosso, P; Colicchia, M; Boeri, L; Serino, A; Castagna, G; Clementi, M C; La Croce, G; Regina, C; Bianchi, M; Mirone, V; Damiano, R; Montorsi, F; Salonia, A

    2016-09-01

    Despite complex interactions between obesity, dyslipidemia, hyperinsulinaemia, and the reproductive axis, the impact of metabolic syndrome on human male reproductive function has not been analysed comprehensively. Complete demographic, clinical, and laboratory data from 1337 consecutive primary infertile men were analysed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (categorised 0 vs. 1 vs. 2 or higher). NCEP-ATPIII criteria were used to define metabolic syndrome. Semen analysis values were assessed based on the 2010 World Health Organisation (WHO) reference criteria. Descriptive statistics and logistic regression models tested the association between semen parameters and clinical characteristics and metabolic syndrome. Metabolic syndrome was found in 128 (9.6%) of 1337 men. Patients with metabolic syndrome were older (p metabolic syndrome. Metabolic syndrome patients had lower levels of total testosterone (p metabolic syndrome. Conversely, the two groups did not differ significantly in further hormonal levels, semen parameters, and rate of either obstructive or non-obstructive azoospermia. At multivariate logistic regression analysis, testicular volume (OR: 0.90; p = 0.002) achieved independent predictor status for WHO pathological semen concentration; conversely, age, Charlson Comorbidity Index scores, metabolic syndrome, and inhibin B values did not. No parameters predicted normal sperm morphology and total progressive motility. Metabolic syndrome accounts for roughly 9% of men presenting for primary couple's infertility. Although metabolic syndrome patients have a lower general male health status, semen analysis values seem independent of the presence of metabolic syndrome. PMID:27368157

  5. Detailed molecular and clinical investigation of a child with a partial deletion of chromosome 11 (Jacobsen syndrome

    Directory of Open Access Journals (Sweden)

    Peitsidis Panagiotis

    2009-12-01

    Full Text Available Abstract Background Jacobsen syndrome (JBS is a rare chromosomal disorder leading to multiple physical and mental impairment. This syndrome is caused by a partial deletion of chromosome 11, especially subband 11q24.1 has been proven to be involved. Clinical cases may easily escape diagnosis, however pancytopenia or thrombocytopenia may be indicative for JBS. Results We report a 7.5 years old boy presenting with speech development delay, hearing impairment and abnormal platelet function. High resolution SNP oligonucleotide microarray analysis revealed a terminal deletion of 11.4 Mb in size, in the area 11q24.1-11qter. This specific deletion encompasses around 170 genes. Other molecular techniques such as fluorescence in situ hybridization and multiplex ligation-dependent probe amplification were used to confirm the array-result. Discussion Our results suggest that the identification and detailed analysis of similar patients with abnormal platelet function and otherwise mild clinical features will contribute to identification of more patients with 11q deletion and JBS.

  6. Clinical and Pathological Investigation on Turkey Diseases in North-central City of Jos, Nigeria, 2009-2014

    Directory of Open Access Journals (Sweden)

    Olatunde Babatunde Akanbi

    2015-12-01

    Full Text Available Information on turkey production and disease is rare in Nigeria, possibly because turkeys are seldom raised commercially. Also, turkeys require intensive husbandry and health care after hatching, which backyard poultry producers hardly provided especially, when raised in a disease endemic environment. In an attempt to document the diseases militating against turkey production in Nigeria, clinical and necropsy records were reviewed from veterinary practices in Jos and the Central Diagnostic Laboratory of the National Veterinary Research Institute (NVRI, Vom, Nigeria between 2009 - 2014. A total of 306 turkeys from backyard flocks were presented to the Veterinary clinics between 2009-2014 with various health complaints by backyard flock owners. Viral (Pox and Newcastle disease and parasitic (Helminthosis, Coccidiosis and Ectoparasitism diseases were mostly diagnosed. During the same period, 42 samples comprising 25 carcasses and 17 cloacal swabs were submitted for post mortem examination, virus isolation and microbiological test. Colisepticaemia, colibacillosis, pullorum disease, airsacculitis and infectious sinusitis are the main diseases diagnosed at post-mortem examination and microbiological test, while none of the samples were positive for influenza by virus isolation. It was observed that turkey rearing was small-scaled and kept as backyard poultry in North-central Nigeria. It can therefore be concluded from this study that turkeys raised in north-central city of Jos are affected by diseases ranging from viral to bacterial and parasitic, which can adversely affect productivity. This can therefore be improved upon by controlling the diseases mostly affecting turkeys.

  7. 3D optical measuring technologies for dimensional inspection

    International Nuclear Information System (INIS)

    The results of the R and D activity of TDI SIE SB RAS in the field of the 3D optical measuring technologies and systems for noncontact 3D optical dimensional inspection applied to atomic and railway industry safety problems are presented. This activity includes investigations of diffraction phenomena on some 3D objects, using the original constructive calculation method, development of hole inspection method on the base of diffractive optical elements. Ensuring the safety of nuclear reactors and running trains as well as their high exploitation reliability takes a noncontact inspection of geometrical parameters of their components. For this tasks we have developed methods and produced the technical vision measuring systems LMM, CONTROL, PROFILE, and technologies for non-contact 3D dimensional inspection of grid spacers and fuel elements for the nuclear reactor VVER-1000 and VVER-440, as well as automatic laser diagnostic system COMPLEX for noncontact inspection of geometrical parameters of running freight car wheel pairs. The performances of these systems and the results of the industrial testing at atomic and railway companies are presented

  8. Multivariate image analysis for quality inspection in fish feed production

    DEFF Research Database (Denmark)

    Ljungqvist, Martin Georg

    focused on here are: pellet size, type and concentration level of astaxanthin in pellet coating, as well as astaxanthin type detected in salmonid fish. Methods used are three different devices for multi- and hyper-spectral imaging, together with shape analysis and multi-variate statistical analysis. The...... results of the work demonstrate a high potential of image analysis and spectral imaging for assessing the product quality of fish feed pellets, astaxanthin and fish meat. We show how image analysis can be used to inspect the pellet size, and how spectral imaging can be used to inspect the surface quality...... origin, or synthesised chemically. Common for both types is that they are relatively expensive in comparison to the other feed ingredients. This thesis investigates multi-variate data collection for visual inspection and optimisation of industrial production in the fish feed industry. Quality parameters...

  9. Inspection and its role in the case for nuclear power

    International Nuclear Information System (INIS)

    An attempt has been made to support the claim that the continuing development and expansion of nuclear power are necessary to meet a probable energy famine in the forseeable future. The need to convince the public to accept and promote the nuclear option is pressing. The possibility of accidents due to human error is discussed. Inspection is a discipline which has arisen to overcome human failings. It can complement design and operational excellence and so make the chance of a major plant accident truly negligible. This argument can be put convincingly to the informed public with good hope of acceptance. Inspection is a neglected discipline and there is much scope for study and original work. In many areas a positive research contribution may be made which would enhance the effectiveness of inspection and add still further to safety and success in the nuclear debate. Several important topics have been identified as worth investigation. (author)

  10. Nondestructive Evaluation (NDE) for Inspection of Composite Sandwich Structures

    Science.gov (United States)

    Zalameda, Joseph N.; Parker, F. Raymond

    2014-01-01

    Composite honeycomb structures are widely used in aerospace applications due to their low weight and high strength advantages. Developing nondestructive evaluation (NDE) inspection methods are essential for their safe performance. Flash thermography is a commonly used technique for composite honeycomb structure inspections due to its large area and rapid inspection capability. Flash thermography is shown to be sensitive for detection of face sheet impact damage and face sheet to core disbond. Data processing techniques, using principal component analysis to improve the defect contrast, are discussed. Limitations to the thermal detection of the core are investigated. In addition to flash thermography, X-ray computed tomography is used. The aluminum honeycomb core provides excellent X-ray contrast compared to the composite face sheet. The X-ray CT technique was used to detect impact damage, core crushing, and skin to core disbonds. Additionally, the X-ray CT technique is used to validate the thermography results.

  11. Radiographic inspection on offshore platforms

    International Nuclear Information System (INIS)

    One of the great challenges for non-destructive inspection is on offshore platforms, where safety is a critical issue. Inspection by gammagraphy is practically forbidden on the platform deck due to problems to personnel safety and radiological protection. Ir-192 sources are used and the risk of an accident with loss of radioisotope must be considered. It is unfeasible to use gammagraphy, because in case of an accident the rapid evacuation from the platform would be impossible. This problem does not occur when X-ray equipment is used as the radiation source. The limited practicality and portability of the X-ray equipment have prevented its use as a replacement for the gammagraphy. This paper presents the preliminary tests to see the viable use of radiographic tests with constant potential on offshore platforms. (author). 2 refs., 1 fig., 2 tabs, 3 photos

  12. Vehicle and cargo inspection system

    Science.gov (United States)

    Verbinski, Victor V.; Orphan, Victor J.

    1997-02-01

    Vehicle and Cargo Inspection System (VACIS) is comprised of a 1 Curie 137Cs gamma-ray source in a shield and collimator which produces a fan-shaped beam designed to intercept a vertical array of gama-ray detectors contained in a tower structure. The source and detector modules straddle the vehicle or container being inspected and are mounted on self-propelled trolleys which travel in synchronization along two parallel tracks covering the length of the scanned object. The signals from the gamma-ray detector array are processed and displayed so as to produce a 2D gamma-radiographic image of the object. Testing of the system on a variety of empty and lightly-loaded vehicles and containers has demonstrated the effectiveness of VACIS in detecting hidden contraband. For example, a small sample of cocaine only 1.5 inches thick was readily detected in a container.

  13. Drum inspection robots: Application development

    International Nuclear Information System (INIS)

    Throughout the Department of Energy (DOE), drums containing mixed and low level stored waste are inspected, as mandated by the Resource Conservation and Recovery Act (RCRA) and other regulations. The inspections are intended to prevent leaks by finding corrosion long before the drums are breached. The DOE Office of Science and Technology (OST) has sponsored efforts towards the development of robotic drum inspectors. This emerging application for mobile and remote sensing has broad applicability for DOE and commercial waste storage areas. Three full scale robot prototypes have been under development, and another project has prototyped a novel technique to analyze robotically collected drum images. In general, the robots consist of a mobile, self-navigating base vehicle, outfitted with sensor packages so that rust and other corrosion cues can be automatically identified. They promise the potential to lower radiation dose and operator effort required, while improving diligence, consistency, and documentation

  14. CRDM nozzle inspection/repair

    International Nuclear Information System (INIS)

    The susceptibility of Alloy 600 to Primary Water Stress Corrosion Cracking (PWSCC) continues to plague nuclear power plants. Recently, the problem PWSCC has manifested itself in Control Rod Drive Mechanism (CRDM) head penetrations in nuclear plants in Europe and the U.S. B and W Nuclear Technologies (BWNT) has been involved in responding to this potentially industry-wide concern through the B and W Owners Group (B and WOG). The program also includes work performed in cooperation with the Nuclear Energy Institute (NEI) Task Force and other Owners Groups. BWNT, building on our parent company's (Framatome) technology, has also developed a fully integrated service package and robotic manipulator to inspect and repair CRDM head penetrations for U.S. utilities. This paper describes the work performed by the B and WOG to address this issue globally, and the overall range of inspection and repair tooling and processes developed by Framatome and BWNT to address this issue. (author). 6 figs

  15. Inspection technologies -Development of national safeguards technology-

    International Nuclear Information System (INIS)

    17 facility regulations prepared by nuclear facilities according to the Ministerial Notices were evaluated. Safeguards inspection activities under Safeguards are described. Safeguards inspection equipments and operation manuals to be used for national inspection are also described. Safeguards report are produced and submitted to MOST by using the computerized nuclear material accounting system at state level. National inspection support system are developed to produce the on-site information for domestic inspection. Planning and establishment of policy for nuclear control of nuclear materials, international cooperation for nuclear control, CTBT, strengthening of international safeguards system, and the supply of PWRs to North Korea are also described. (author). 43 tabs., 39 figs

  16. 2015 Bridge Inspection ERC Training

    OpenAIRE

    Dougherty, Merril

    2015-01-01

    This presentation will discuss recent changes to the County Bridge Inspection Program from the perspective of both the FHWA and INDOT. We will also discuss the responsibilities of the local public agency’s (LPA’s) employee in responsible charge (ERC) with respect to managing this program. As this course is a yearly requirement, all county ERCs are encouraged to attend. Pre-registering is strongly encouraged by e-mailing your contact information to .

  17. Inspection and appraisal of operational programs

    International Nuclear Information System (INIS)

    The accident at Three Mile Island in March 1979 and the subsequent investigations identified, among other items, serious concerns involving several aspects of the radiation protection program. Significantly, some of the concerns involved areas which were not addressed by regulations or facility technical specifications. This led to the additional concern that similar problems might exist at other operating power reactor facilities. In response to these concerns, the NRC's Office of Inspection and Enforcement (IE) initiated, during calendar year 1980, a major effort to evaluate the adequacy and effectiveness of radiation protection programs at all currently operating nuclear power facilities. This inspection effort was termed an appraisal since it was structured to facilitate an integrated look at the total radiation protection program, delved into matters for which explicit regulatory requirements did not exist and emphasized evaluation of capability and performance rather than compliance with regulations. The results of the 48 appraisals are discussed and the anticipated regulatory actions which may be taken to further address the concerns are identified

  18. INVESTIGATION OF ANTIMICROBIAL ACTIVITY COMBINED PREPARATIONS FOR CLINICAL STRAINS OF MICROORGANISMS ISOLATED FROM PATIENTS WITH BACTERIAL VAGINIT

    Directory of Open Access Journals (Sweden)

    Aslanian M. A.

    2015-12-01

    Full Text Available The problem of bacterial vaginit in some cases the cause of severe infectious diseases genitalia of the fetus and newborn, which can impair the health of future generations. It is noted that the treatment of antibacterial agents observed numerous negative side effects- reducing the biochemical activity of the intestinal microflora, abuse microbiota, leading to the development of dysbiosis, increasing the number of resistant strains of pathogens, the risk of allergic reaction sand immunological disorders. A study was conducted towards finding effective combinations of drugs from different pharmacological groups means to create a combination of drugs. The aim of the study was to develop and explore and Flamini combination of miramistin combined medicines to treat bacterial vaginit. As a result of studies in patients with bacterial vaginit pathological material was isolated and identified 72 strains of microorganisms (Staphylococcus spp, Streptococcus spp, Enterococcus spp, Escherichia coli, Haemophillu sssp, Candida albican sand various strains of anaerobic microorganisms. For the combined treatment of infectious and in flammatory diseases (mixed infections in humans the combined drugin tablet form. All clinical strains of microorganisms isolated from patients with bacterial vaginit were tested for sensitivity to the combined preparation in tablet form with Flamini and miramistin. The greatest sensitivity to the drugs found clinical strains of microorganisms: Staphylococcu saureus, Staphylococcus epidermidis, Peptococcus niger (diameter zone growth retardation is 25,5-23,5 mm. composition tablets number 1 (0.05 g Flamini, miramistini 0.02 g, which was selected for further study shows bacteriostatic effect against a wide range of microorganisms and fungi Rod Candida. IPC for Staphylococcus sp was 20-25 pg / mL for Streptococcus sp 35,0-40,0 mg / ml, for intestinal group 35,0-40,0 for fungi 30,0 mg / ml unlike pills number 2 and number 3, where the

  19. Inspection device for buried equipment

    International Nuclear Information System (INIS)

    In an inspection device for a buried equipment, a rail is suspended at the upper portion of a vessel of a pit-vessel type pump buried in a plant building floor, and a truck movable vertical in the vessel along the rail, and an ultrasonic wave probe contained in the truck and urged to the vessel by an electromagnet are disposed. In addition, an elevator moving vertically along a shaft is disposed, and an arm having the ultrasonic probe disposed at the end portion and driven by a piston are disposed to the elevator. The ultrasonic wave probe moves vertically together with the truck along the rail in the vessel while being urged to the vessel by the electromagnet to inspect and measure the state at the inner and outer surfaces of the vessel. Further, the length of the arm is controlled so as to set a predetermined distance between the ultrasonic wave probe and the vessel. Subsequently, the elevator is moved vertically along a shaft passing through a shaft hole of a mount, and the shaft is rotated thereby enabling to inspect and measure the state of the inner and outer surfaces of the vessel. (N.H.)

  20. Using Pipe For Inspection Applications

    Science.gov (United States)

    Luck, Randall L.

    1987-05-01

    This paper will describe PIPE and how its capabilities can be used for inspection applications. PIPE is a high performance parallel processor with an architecture specifically designed for the processing of video images at up to 60 fields per second. The unit is modular and programmable. It processes sequences of images through a pipeline of point processors, image buffers and arithmetic or Boolean neighborhood operators. There are multiple data pathways between the stages in forward, recursive and backward directions that allow images to interact in many useful ways. Due to its architecture, PIPE inherently allows the processing of many images simultaneously for working with dynamic scenes or multiple combinations of the same image. Although originally designed for robot guidance applications, PIPE has many features that make it well suited for use in inspection. For these inspection applications, this multiple image capability allows the pipelining of different processes on different images at the same time. In addition, a programmable region of interest capability allows different processes to be run on different areas of the same image. Illustrations of some these techniques will be presented.

  1. AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials

    Science.gov (United States)

    Wheeler, Graham M.; Sweeting, Michael J.; Mander, Adrian P.

    2016-01-01

    In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities. PMID:27403961

  2. Intelligent Automated Nuclear Fuel Pellet Inspection System

    International Nuclear Information System (INIS)

    At the present time, nuclear pellet inspection is performed manually using naked eyes for judgment and decisionmaking on accepting or rejecting pellets. This current practice of pellet inspection is tedious and subject to inconsistencies and error. Furthermore, unnecessary re-fabrication of pellets is costly and the presence of low quality pellets in a fuel assembly is unacceptable. To improve the quality control in nuclear fuel fabrication plants, an automated pellet inspection system based on advanced techniques is needed. Such a system addresses the following concerns of the current manual inspection method: (1) the reliability of inspection due to typical human errors, (2) radiation exposure to the workers, and (3) speed of inspection and its economical impact. The goal of this research is to develop an automated nuclear fuel pellet inspection system which is based on pellet video (photographic) images and uses artificial intelligence techniques

  3. Generative inspection process planner for integrated production

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C.W. (Allied-Signal Aerospace Co., Kansas City, MO (USA). Kansas City Div.); Gyorog, D.A. (Kansas Univ., Lawrence, KS (USA). Dept. of Mechanical Engineering)

    1990-04-01

    This work describes the design prototype development of a generative process planning system for dimensional inspection. The system, IPPEX (Inspection Process Planning EXpert), is a rule-based expert system for integrated production. Using as advanced product modeler, relational databases, and artificial intelligence techniques, IPPEX generates the process plan and part program for the dimensional inspection of products using CMMs. Through an application interface, the IPPEX system software accesses product definition from the product modeler. The modeler is a solid geometric modeler coupled with a dimension and tolerance modeler. Resource data regarding the machines, probes, and fixtures are queried from databases. IPPEX represents inspection process knowledge as production rules and incorporates an embedded inference engine to perform decision making. The IPPEX system, its functional architecture, system architecture, system approach, product modeling environment, inspection features, inspection knowledge, hierarchical planning strategy, user interface formats, and other fundamental issues related to inspection planning and part programming for CMMs are described. 27 refs., 16 figs., 4 tabs.

  4. Investigation of the effects of vitamin D and calcium on intestinal motility: In vitro tests and implications for clinical treatment

    Directory of Open Access Journals (Sweden)

    Giraldi Guglielmo

    2015-09-01

    Full Text Available The presence of vitamin D receptors in small intestine muscle cells may lead one to think that vitamin D may act locally, influencing intracellular calcium concentration and contributing to the contraction-relaxation regulation of the intestinal smooth muscle cells. This study investigates the potential effects of vitamin D and calcium on intestinal motility using an in vitro test.

  5. Diagnosis of regional cerebral blood flow abnormalities using SPECT: agreement between individualized statistical parametric maps and visual inspection by nuclear medicine physicians with different levels of expertise in nuclear neurology

    OpenAIRE

    Euclides Timóteo da Rocha; Carlos Alberto Buchpiguel; Ricardo Nitrini; Sergio Tazima; Stela Verzinhase Peres; Geraldo Busatto Filho

    2009-01-01

    INTRODUCTION: Visual analysis is widely used to interpret regional cerebral blood flow (rCBF) SPECT images in clinical practice despite its limitations. Automated methods are employed to investigate between-group rCBF differences in research studies but have rarely been explored in individual analyses. OBJECTIVES: To compare visual inspection by nuclear physicians with the automated statistical parametric mapping program using a SPECT dataset of patients with neurological disorders and normal...

  6. Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation

    Directory of Open Access Journals (Sweden)

    Dennis BB

    2014-11-01

    Full Text Available Brittany B Dennis,1 M Constantine Samaan,2 Monica Bawor,3 James Paul,4 Carolyn Plater,5 Guillaume Pare,1 Andrew Worster,6 Michael Varenbut,5 Jeff Daiter,5 David C Marsh,5,7 Dipika Desai,8 Lehana Thabane,1,9,10 Zainab Samaan1,8,11 1Department of Clinical Epidemiology and Biostatistics, 2Department of Pediatrics, Division of Pediatric Endocrinology, 3McMaster Integrative Neuroscience Discovery and Study Program, 4Department of Anesthesia, McMaster University, Hamilton, 5Ontario Addiction Treatment Centres, Richmond Hill, 6Department of Medicine, Hamilton General Hospital, Hamilton, 7Northern Ontario School of Medicine, Sudbury, 8Population Genomics Program, Chanchlani Research Centre, McMaster University, Hamilton, 9Centre for Evaluation of Medicine, 10System Linked Research Unit, Hamilton, 11Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada Background: Chronic pain is the most commonly reported comorbidity among patients with opioid addiction receiving methadone maintenance treatment (MMT, with an estimated prevalence ranging between 30% and 55%. Evidence suggests that patients with comorbid pain are at high risk for poor treatment response, including continued illicit substance use. Due to the important relationship between the presence of pain and illicit substance abuse within the MMT setting, it is imperative that we target our efforts toward understanding the characteristics of this patient population.Methods: The primary objective of this study was to explore the clinical and inflammatory profile of MMT patients reporting comorbid pain. This multicenter study enrolled patients (n=235 on MMT for the treatment of opioid dependence. Clinical history and blood and urine data were collected. Blood samples were obtained for estimating the serum levels of inflammatory markers (tumor necrosis factor [TNF]-α, interleukin-1 receptor antagonist [IL-1ra], IL-6, IL-8, IL-10, interferon [IFN]-γ and

  7. Features of 152 families eligible for the investigation of mutations in BRCA1 / 2, evaluated Onco genetics unit Clinics Hospital

    International Nuclear Information System (INIS)

    Full text: The aim of this study is to contribute to the characterization of familial breast cancer in our country. Patients and methods. We analyzed 152 families referred to the Hospital Unit Onco genetics Clinic, who had 3 or more cases of breast cancer (C M)(at least one diagnosed before age 50 years) (n = 92)or 2 cases with some sub-criterion (paternal transmission, C M bilateral C M male, ovarian cancer (O C), Ashkenazi Jewish ancestry, a case diagnosed before 40 years) (n = 47)or 4 or more cases without regard to age at diagnosis (n = 4)or an single case diagnosed before age 35 (n = 9). The clinical data collection was conducted onco genetics the query was entered in which, among others, the presence or absence of nongenetic risk factors, personal and family history of breast, ovarian and other tumors and age of diagnosis. Results. 152 cases were selected indices, carrying 148 C M (bilateral n = 29)and 4 CO. The median age at diagnosis of C M developed in these patients was 48 years (range: 25-54). Twenty-three of the 151 patients had a second tumor extra mammary (ovary n = 7; melanoma n = 2, n = 3 cervix, colon n = 4, n = 1 sarcoma, ENT = 1, = 1 pancreas, kidney = 2, CBP = 1, esophagus = 1). Among the relatives of the relevant parent branch were 329 C M (25 bilateral, 2 male)diagnosed before 50 years in more than 60 % of cases and 22 ovarian cancers. Comparing the frequency of different tumor locations both branches parents. In the relevant parent branch, and the prevalence of C M and CO documented a higher frequency of prostate, stomach, pancreas and melanoma. It was possible to obtain information He r2 tumor expression, estrogen receptor (E R) and progesterone receptor (P R) in 25 patients, finding that 10 patients (0.40)had He r2 overexpression, 11 (0.46 R E and / / or P R positive, HER2 negative and 4 E R, P R and He r2 negative (0.16). Conclusions. The characteristics of the families studied, including the frequency of tumors extramamarios agrees with

  8. Contribution of SLN investigation with 99mTc-nanocolloid in clinical staging of thyroid cancer: technical feasibility

    International Nuclear Information System (INIS)

    It is a matter of controversy whether prophylactic lymph node dissection improves prognosis and survival in papillary thyroid carcinoma (PTC) patients without suspicion of lymph node metastases either clinically or on ultrasonography. It is possible that in such patients the use of lymphatic mapping and sentinel lymph node (SLN) biopsy, as are employed for other tumours, will be of assistance. The aim of this study was to evaluate the feasibility of preoperative 99mTc-nanocolloid lymphoscintigraphy and an intra-operative SLN procedure in the management of PTC patients. Twenty-five consecutive patients were entered in the study between April 2005 and October 2005. All had a preoperative diagnosis of malignancy obtained by fine-needle aspiration cytology (FNAC), without clinical or ultrasonographic evidence of loco-regional lymph node involvement. Patients underwent preoperative lymphoscintigraphy after the injection of 99mTc-nanocolloid [median 6 MBq (range 4-9 MBq) in 0.1-0.2 ml saline injected intratumorally under ultrasound guidance] and an intra-operative SLN procedure using a hand-held gamma probe. Surgery was performed by the same surgeon in all patients. Preoperative lymphoscintigraphy identified at least one SLN in all patients. During surgery, using the gamma probe, the surgeon was able to find at least one SLN in all cases. A good correlation was found between preoperative imaging and probe results. Metastasis was found in at least one SLN in 12 (48%) patients. In seven (28%) patients the involved SLN was the most radioactive SLN, while in five (20%) patients a less radioactive SLN was involved by malignancy. Ten of these 12 patients had only micrometastases (<2 mm). Micrometastases were found in the most radioactive SLN in six cases and in less radioactive SLNs in four cases, while in two patients more lymph nodes visualised at lymphoscintigraphy ipsilateral to the primary tumour were sites of metastasis. The rate of nodal involvement was very high in our

  9. Developing the information management system for safeguards national inspection

    Energy Technology Data Exchange (ETDEWEB)

    Park, S. J.; Jeon, I.; Park, W. S.; Min, K. S. [KAERI, Taejon (Korea, Republic of)

    2003-10-01

    The inspection information management system for safeguards national inspection is aimed to do the national safeguards inspection with efficiency, and to decrease the inspector's load to write inspection report by systematizing the inspection jobs and sharing the inspection data. National safeguards inspection is consisted two large jobs. The first is the national safeguards supporting job of managing to support the national inspection mission. The other is the writing a national inspection report after completing the national inspection. Before the developing of inspection information management system, the official tools(spread sheet, word processor) are usually used. But there is problem to share the data, to produce the statistics data. To solve the these problem, we developed the inspection information management system that process the job from initial to final inspection work, and opened user education. This paper explain the procedure of developing the inspection information management system for safeguards national inspection.

  10. Elements determination of clinical relevance in biological tissues Dmdmdx/J dystrophic mice strains investigated by NAA

    International Nuclear Information System (INIS)

    In this work the determination of chemistry elements in biological tissues (whole blood, bones and organs) of dystrophic mice, used as animal model of Duchenne Muscular Dystrophy (DMD), was performed using analytical nuclear technique. The aim of this work was to determine reference values of elements of clinical (Ca, Cl, K, Mg, Na) and nutritional (Br and S) relevance in whole blood, tibia, quadriceps and hearts from Dmdmdx/J (10 males and 10 females) dystrophic mice and C57BL/6J (10 males) control group mice, using Neutron Activation Analysis technique (NAA). To show in more details the alterations that this disease may cause in these biological tissues, correlations matrixes of the DMDmdx/J mouse strain were generated and compared with C57BL/6J control group. For this study 119 samples of biological tissue were irradiated in the IEA-R1 nuclear reactor at IPEN (Sao Paulo, Brazil). The concentrations of these elements in biological tissues of Dmdmdx/J and C57B/6J mice are the first indicative interval for reference values. Moreover, the alteration in some correlation coefficients data among the elements in the health status and in the diseased status indicates a connection between these elements in whole blood, tibia, quadriceps and heart. These results may help the researchers to evaluate the efficiency of new treatments and to compare the advantages of different treatment approaches before performing tests in patients with muscular dystrophy. (author)

  11. Relationship Between Bone Minerals Density and Some Characteristics of Postmenopausal Women who Were Visiting Orthopedics Clinics - Original Investigation

    Directory of Open Access Journals (Sweden)

    Gülendam Karadağ

    2007-12-01

    Full Text Available Aim: Frequency of osteoporosis that depending different factors in postmenopausal women is increase. So our study was done to determine the relationship between some habits of the postmenopausal women and bone mineral density. Material and Methods: The study was done as descriptive a hospital in Gaziantep between the dates 3 July - 8 August, 2006. The comprehension of the study is all patients who applied to orthopedics clinics, and sampling consists of 70 patients who wanted to join study, and postmenopausal, hadn’t taken steroid and calcitonin treatment more than last one year. Before study, informed approwal was taken from patients and institution. Data of the study were collected using questionnaire form. Density of bone minerals was grouped according to the standarts of WHO as normal (t>-1.0, osteopenic (t0.05. Conclusion: It was seen that majority of patients didn’t make sports regularly, and the risk of having osteoporosis was higher who were getting older. For this reason, it can be suggested that to prevent osteoporosis especially in postmenopausal women necessary education should be given. (From the World of Osteoporosis 2007;13:75-9

  12. A Clinical Investigation into the Factors Influencing the Prognosis of Patients with Primary Liver Cancer after Hepatectomy

    Institute of Scientific and Technical Information of China (English)

    Ji Xi-qing; Li Chao-long; Sheng Xing-hua

    2005-01-01

    Objective To explore the factors influencing the prognosis of patients with primary liver cancer(PLC) after hepatectomy on purpose to provide the preventive measures for improving the long-term effect.Methods All of the 189 patients who underwent hepatectomy with PLC from May,1994 to January,1998 were included by reviewing their clinical pathological characteristics and treatments. Totally, 22 factors contributed to the long-term survival rate(SR)and the disease-free SR were analysed . All patients were followed up at least 5 years. Results The 3- and 5-year cumulative SRs in the total group were 63% and 45% respectively. The 3- and 5-year SRs and disease-free SRs in the curative resection (CR) group (n=162) were 67%,47%,and 45% and 26% respectively. It was showed that the way by which a tumor was found, tumor size, portal thrombi, satellite nodule, cirrhosis type, TNM stage, tumor envelope, recurrence and treatment, vascular exclusion and transfusion, differentiation grade and CR were prognostic factors by individual variable analysis. A multivariable analysis showed that CR , tumor size and reoperation were significant factors associated with the prognosis. Conclusion The type of CR and tumor size are determinants influencing the prognosis. Early diagnosis of small carcinoma and CR as soon as possible is essential to improving the prognosis of PLC. Avoiding transfusion and controlling the progress of cirrhosis are expected to improve the disease-free SR.

  13. Hippocratic oath and conversion of ethico-regulatory aspects onto doctors as a physician, private individual and a clinical investigator.

    Science.gov (United States)

    Imran, Mohammed; Samad, Shadab; Maaz, Mohammad; Qadeer, Ashhar; Najmi, Abul Kalam; Aqil, Mohammed

    2013-10-01

    Hippocratic Oath is a living document for ethical conduct of the physicians around the world. World Medical Association has been amending the oath as per the contemporary times. Although physicians maintain their ethical standards while treating a patient yet many a times social, administrative and ruling powers either use physicians as their tool of oppression or victimize them for conducting duties as per their oath. The Tuskegee Syphilis Study and Human Radiation Experiments in America, Nazi Experiments in Germany and compulsory sterilization program in India were the studies where States used physicians for the advancement of their rationality or belief. Conversely victimization of physicians in Kosovo, Sri Lanka and incarcerating physicians for treating human immunodeficiency virus/acquired immunodeficiency syndrome patients in some countries is concerning. The Nuremberg code, the Declaration of Geneva, Belmont Report and Declaration of Helsinki are ethical documents while active involvement of Food and Drug Administration through "common rule" resulted in guidelines like International Conference on Harmonization and Good Clinical Practices. Still unethical studies are found in developing countries. Studies such as experimental anticancer drugs in 24 cancer patients without adequate prior animal testing and informed consent in Kerala, studies at All India Institute of Medical Sciences in New Delhi resulted in 49 deaths of children and many more suspicious studies are rampant. Reverting back to the fundamentals of the medical profession; teaching medical ethics and enforcement of "medical neutrality" by embarking some grade of "medical immunity" on the basis of the oath is necessary for ethical conduct of physicians. PMID:24381460

  14. Clinical investigation of the biological effects of a new combination low-dose oral contraceptive ('Ovostat E').

    Science.gov (United States)

    Tarkkila, T; Hulkko, S; Alapiessa, U; Kauraniemi, T

    1977-01-01

    A low-dose contraceptive containing 1 mg of lynestrenol and .05 mg of ethinyl estradiol was studied over 12 cycles in 11 healthy fertile women volunteers. The subjects were aged 20-30 years. Measurements were taken of urinary luteinizing hormone (LH), pregnanediol, and estrogen, and serum progesterone and estradiol values; in addition, on a fixed schedule during treatment, the 3rd, 5th, 7th, and 12th months, vaginal smears and endometrial biopsies were taken, along with SGOT and SGPT determinations. According to determinations, ovulation was inhibited during every cycle tested. A clear estrogenic effect was evident in the karyopyknotic index, during cycle 3, at the beginning of the cycle which became a progestational effect around Day 13 (biphasic). In cycle 6, the indexes of cytology decreased, but during Cycle 12, they rose a bit again. Basal body temperature during treatment was monophasic. Cervical mucus assessed by spinnbarket during treatment was low and arborization absent. The SGOT and SGPT liver function tests were within normal values in all cycles in 7 women; 4 showed clearly higher levels in Cycles 3 and 12. None of the cycles showed the high midcycle urinary excretion of LH. No significant side effects were reported. Examination of the endometrial biopsies showed a drug effect in all cases and there was no secretory activity in any of the samples. These findings confirm clinical results that show this low-dose combination to be an effective contraceptive agent. PMID:162661

  15. An investigation into the feasibility of designing a framework for the quantitative evaluation of the Clinical Librarian service at an NHS Trust in Brighton, UK.

    Science.gov (United States)

    Deshmukh, Archana; Roper, Tom

    2014-12-01

    This feature presents research undertaken by Archana Deshmukh for her MA dissertation at the University of Brighton. She worked closely with Tom Roper, the Clinical Librarian at Brighton and Sussex University Hospitals NHS Trust, in a project to explore the feasibility of applying quantitative measures to evaluate the Clinical Librarian service. The investigation used an innovative participatory approach and the findings showed that although an exclusively quantitative approach to evaluation is not feasible, using a mixed methods approach is a way forward. Agreed outputs and outcomes could be embedded in a marketing plan, and the resulting framework could provide evidence to demonstrate overall impact. Archana graduated in July 2014, gaining a Distinction in the MA in Information Studies, and she is currently looking for work in the health information sector. PMID:25443028

  16. Legal and ethical obligations to conduct a clinical drug trial in Australia as an investigator initiated and sponsored study for an overseas pharmaceutical company.

    Science.gov (United States)

    Beran, Roy G

    2004-01-01

    Most multi-centre trials are both financed and sponsored by the pharmaceutical company involved. What follows will map the path adopted for an investigator initiated and sponsored study for a new indication of an established medication. The chief investigators of a company-sponsored, investigator-initiated, multi-centre, placebo-controlled study of an established medication, Pharmaceutical Benefit Scheme (PBS) listed for treatment of one condition but trialled in the management of another condition (trial of off-label use), were approached to submit a protocol to repeat the type of study with a different compound. The new study would test a different agent, also PBS listed, for the same condition as in the initial study and with the same off-licence application. The company would finance the study, provide the medication and matched placebo but only review the investigator-initiated protocol which would be sponsored by the principal investigator. This required the investigator to implement the trial, as would normally be done by the pharmaceutical company, yet also act as its principal investigator. The principal investigator, with colleagues and a Clinical Research Organisation (CRO), developed a protocol, adapted for the new agent, and submitted it for approval. Upon acceptance a contract was negotiated with the pharmaceutical company which had to overcome jurisdictional conflicts between common law and civil law legal systems. A CRO was contracted to undertake administrative functions which dictated special contractual agreements to overcome possible conflicts of interest for a sponsor/investigator to protect patient interests. There was need to find indemnification insurance with jurisdictional problems, co-investigators, ethics committee approvals and finance management as just some of the difficulties encountered. The paper will outline how these obstacles were overcome and how ethical and legal issues were respected through compromise. The ethical and legal

  17. Investigation of class 1 integrons in Klebsiella pneumoniae clinical and microbiota isolates belonging to different phylogenetic groups in Recife, State of Pernambuco

    Directory of Open Access Journals (Sweden)

    Alexsandra Maria Silva Lima

    2014-04-01

    Full Text Available Introduction The high prevalence of Klebsiella pneumoniae infections is related to the ability of K. pneumoniae to acquire and disseminate exogenous genes associated with mobile elements, such as R plasmids, transposons and integrons. This study investigated the presence of class 1 integrons in clinical and microbiota isolates of K. pneumoniae belonging to different phylogenetic groups and correlated these results with the antimicrobial resistance profiles of the studied isolates. Methods Of the 51 isolates of K. pneumoniae selected for this study, 29 were from multidrug-resistant clinical isolates, and 22 were from children's microbiota. The susceptibility profile was determined using the disk diffusion method, and class 1 integrons were detected through polymerase chain reaction (PCR. Results The results showed that none of the 22 microbiota isolates carried class 1 integrons. Among the 29 clinical isolates, 19 (65.5% contained class 1 integrons, and resistance to sulfamethoxazole/trimethoprim was identified in 18 of these isolates (94.7%. Among the K. pneumoniae isolates with class 1 integrons, 47% belonged to the KpI phylogenetic group, and one isolate (14.3% carrying these genetic elements belonged to the KpIII group. Conclusions The wide variety of detected class 1 integrons supports the presence of high rates of antimicrobial resistance, genetic variability, and rapid dissemination of beta-lactamase genes among K. pneumoniae clinical isolates in recent years in hospitals in Recife-PE, Brazil. The findings of this study indicate that the surveillance of K. pneumoniae integrons in clinical isolates could be useful for monitoring the spread of antibiotic resistance genes in the hospital environment.

  18. Clinical investigation of weekly carboplatin and paclitaxel with concurrent radiation therapy for locally advanced non-small cell lung cancer

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate retrospectively chemotherapy of weekly carboplatin and paclitaxel with concurrent radiation therapy for patients with locally advanced non-small cell lung cancer (NSCLC). Between January 2000 and March 2008, 38 patients were treated by chemotherapy with carboplatin and paclitaxel once a week, repeated for 6 weeks, with thoracic radiation therapy of 1 or 2 times a day on weekdays. After concurrent chemoradiotherapy, we planned consolidation chemotherapy of carboplatin (area under the curve (AUC) 5-6) and weekly paclitaxel (70-80 mg/m2) on day 1, 8 and 15, when possible. The enrolled patients were 31 men and 7 women, with the median age of 59 years (39-76 years), stage IIIA/IIIB: 10/28, Ad/Sq/AdSq/Un: 17/17/2/2. The response rate of this chemoradiotherapy was 78.9%. The median survival time and time to progression were 24.7 months and 8.1 months, respectively. Grade 3 or 4 hematological toxicities during concomitant chemoradiotherapy were leukocytopenia (5.2%) and neutropenia (5.2%). Grade 3 or 4 non-hematological toxicities were esophagitis (2.6%) and pneumonitis (5.2%). There was a therapy-associated death by radiation pneumonitis. Carboplatin and paclitaxel with concurrent radiation therapy for a patient with stage III NSCLC showed a good response with relatively mild side effects. We reached the conclusion that concurrent chemoradiotherapy would be a useful choice for locally advanced non-small cell lung cancer on the practical clinic. (author)

  19. Hippocratic oath and conversion of ethico-regulatory aspects onto doctors as a physician, private individual and a clinical investigator

    Directory of Open Access Journals (Sweden)

    Mohammed Imran

    2013-01-01

    Full Text Available Hippocratic Oath is a living document for ethical conduct of the physicians around the world. World Medical Association has been amending the oath as per the contemporary times. Although physicians maintain their ethical standards while treating a patient yet many a times social, administrative and ruling powers either use physicians as their tool of oppression or victimize them for conducting duties as per their oath. The Tuskegee Syphilis Study and Human Radiation Experiments in America, Nazi Experiments in Germany and compulsory sterilization program in India were the studies where States used physicians for the advancement of their rationality or belief. Conversely victimization of physicians in Kosovo, Sri Lanka and incarcerating physicians for treating human immunodeficiency virus/acquired immunodeficiency syndrome patients in some countries is concerning. The Nuremberg code, the Declaration of Geneva, Belmont Report and Declaration of Helsinki are ethical documents while active involvement of Food and Drug Administration through "common rule" resulted in guidelines like International Conference on Harmonization and Good Clinical Practices. Still unethical studies are found in developing countries. Studies such as experimental anticancer drugs in 24 cancer patients without adequate prior animal testing and informed consent in Kerala, studies at All India Institute of Medical Sciences in New Delhi resulted in 49 deaths of children and many more suspicious studies are rampant. Reverting back to the fundamentals of the medical profession; teaching medical ethics and enforcement of "medical neutrality" by embarking some grade of "medical immunity" on the basis of the oath is necessary for ethical conduct of physicians.

  20. Bridging of inspection with corrosion management

    International Nuclear Information System (INIS)

    Formerly, Inspection and Corrosion Engineers have less interaction and sharing of information to each other even they are working in the same plant or organization. Inspection finding either from visual inspection or NDT techniques rarely shared with corrosion engineers. Similarly corrosion engineers rarely discussed their corrosion prediction and potential damage mechanism with inspection engineers. A demanding request of more holistic plant safety and asset integrity promoted the introduction and implementation of Risk Based Inspection (RBI). RBI analysis demands the input mainly from both disciplines i.e. Inspection and Corrosion Engineers. Most of RBI methodologies are once-off analysis approach which also promoted once-off interaction between Inspection and Corrosion Engineers. PETRONAS has developed a methodology with supporting software, integrating both Inspection and Corrosion disciplines. PETRONAS Risk Based Inspection (PRBI) is intended to promote continuous integration of Inspection and Corrosion management of the plant through out the whole life cycle starting from the design stage to fabrication, operation and decommissions stage. (author)

  1. Cognitive correlates of ultrasonic inspection performance

    International Nuclear Information System (INIS)

    This study provided a detailed examination of the thought processes required for conducting successful ultrasonic inspections of nuclear power plant components. When employed to detect or estimate the size of defects in components such as pipes and nozzles, an ultrasonic inspection can be a demanding cognitive task. A successful result requires the mental manipulation of a substantial amount of relevant information: knowledge about the component inspected, understanding of available ultrasonic techniques, and interpretation of an almost infinite variety of signal-characteristics obtained during the inspection. Reaching a correct conclusion from an inspection is a function of both the validity of the information obtained and the effectiveness with which the information is interpreted and weighed. Previous efforts to improve ultrasonic inspection performance have been directed mainly to the improvement of techniques and training for obtaining information. This study addressed improvement of the cognitive processes -- the mental manipulations required to reach a correct conclusion. The study was designed to learn what inspectors were doing and thinking while applying ultrasonic inspection techniques, and to relate key cognitive elements to inspection performance -- that is, to determine what aspects of these cognitive processes discriminate between effective and ineffective inspections. To this end, tape-recorded commentary was obtained and analyzed from 235 inspections of pipe-weld specimens. 26 refs., 39 figs

  2. ANNUAL RADIOACTIVE WASTE TANK INSPECTION PROGRAM - 2011

    Energy Technology Data Exchange (ETDEWEB)

    West, B.; Waltz, R.

    2012-06-21

    Aqueous radioactive wastes from Savannah River Site (SRS) separations and vitrification processes are contained in large underground carbon steel tanks. Inspections made during 2011 to evaluate these vessels and other waste handling facilities along with evaluations based on data from previous inspections are the subject of this report. The 2011 inspection program revealed that the structural integrity and waste confinement capability of the Savannah River Site waste tanks were maintained. All inspections scheduled per SRR-LWE-2011-00026, HLW Tank Farm Inspection Plan for 2011, were completed. Ultrasonic measurements (UT) performed in 2011 met the requirements of C-ESR-G-00006, In-Service Inspection Program for High Level Waste Tanks, Rev. 3, and WSRC-TR-2002-00061, Rev.6. UT inspections were performed on Tanks 25, 26 and 34 and the findings are documented in SRNL-STI-2011-00495, Tank Inspection NDE Results for Fiscal Year 2011, Waste Tanks 25, 26, 34 and 41. A total of 5813 photographs were made and 835 visual and video inspections were performed during 2011. A potential leaksite was discovered at Tank 4 during routine annual inspections performed in 2011. The new crack, which is above the allowable fill level, resulted in no release to the environment or tank annulus. The location of the crack is documented in C-ESR-G-00003, SRS High Level Waste Tank Leaksite Information, Rev.6.

  3. A Robot Based Automatic Paint Inspection System

    Science.gov (United States)

    Atkinson, R. M.; Claridge, J. F.

    1988-06-01

    The final inspection of manufactured goods is a labour intensive activity. The use of human inspectors has a number of potential disadvantages; it can be expensive, the inspection standard applied is subjective and the inspection process can be slow compared with the production process. The use of automatic optical and electronic systems to perform the inspection task is now a growing practice but, in general, such systems have been applied to small components which are accurately presented. Recent advances in vision systems and robot control technology have made possible the installation of an automated paint inspection system at the Austin Rover Group's plant at Cowley, Oxford. The automatic inspection of painted car bodies is a particularly difficult problem, but one which has major benefits. The pass line of the car bodies is ill-determined, the surface to be inspected is of varying surface geometry and only a short time is available to inspect a large surface area. The benefits, however, are due to the consistent standard of inspection which should lead to lower levels of customer complaints and improved process feedback. The Austin Rover Group initiated the development of a system to fulfil this requirement. Three companies collaborated on the project; Austin Rover itself undertook the production line modifications required for body presentation, Sira Ltd developed the inspection cameras and signal processing system and Unimation (Europe) Ltd designed, supplied and programmed the robot system. Sira's development was supported by a grant from the Department of Trade and Industry.

  4. Steam generator tube inspection in Japan

    International Nuclear Information System (INIS)

    Steam generator tube inspection was first carried out in 1971 at Mihama Unit-1 that is first PWR plant in Japan, when the plant was brought into the first annual inspection. At that time, inspection was made on sampling basis, and only bobbin coil probe was used. After experiencing various kinds of tube degradations, inspection method was changed from sampling to all number of tubes, and various kinds of probes were used to get higher detectability of flaw. At present, it is required that all the tubes shall be inspected in their full length at each annual inspection using standard bobbin coil probe, and some special probes for certain plants that have susceptibility of occurrence of flaw. Sleeve repaired portion is included in this inspection. As a result of analyses of eddy current testing data, all indications that have been evaluated to be 20% wall thickness or deeper shall be repaired by either plugging or sleeving, where flaw morphology is to be a wastage or wear. Other types of flaw such as IGA/SCC are not allowed to be left inservice when those indications are detected. These inspections are performed according to inspection procedures that are approved by regulatory authority. Actual inspections are witnessed by the Japan Power engineering and inspection corporation (JAPEIC)'s inspectors during data acquisition and analysis, and they issue inspection report to authority for review and approval. It is achieved high safety performance of steam generator through this method of inspections, however. some tube leakage problems were experienced in the past. To prevent recurrence of such events, government is conducting development and verification test program for new eddy current testing technology

  5. Steam generator tube inspection in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Fukui, Shigetaka [Japan Power Engineering and Inspection Corp., Tokyo (Japan)

    1997-02-01

    Steam generator tube inspection was first carried out in 1971 at Mihama Unit-1 that is first PWR plant in Japan, when the plant was brought into the first annual inspection. At that time, inspection was made on sampling basis, and only bobbin coil probe was used. After experiencing various kinds of tube degradations, inspection method was changed from sampling to all number of tubes, and various kinds of probes were used to get higher detectability of flaw. At present, it is required that all the tubes shall be inspected in their full length at each annual inspection using standard bobbin coil probe, and some special probes for certain plants that have susceptibility of occurrence of flaw. Sleeve repaired portion is included in this inspection. As a result of analyses of eddy current testing data, all indications that have been evaluated to be 20% wall thickness or deeper shall be repaired by either plugging or sleeving, where flaw morphology is to be a wastage or wear. Other types of flaw such as IGA/SCC are not allowed to be left inservice when those indications are detected. These inspections are performed according to inspection procedures that are approved by regulatory authority. Actual inspections are witnessed by the Japan Power engineering and inspection corporation (JAPEIC)`s inspectors during data acquisition and analysis, and they issue inspection report to authority for review and approval. It is achieved high safety performance of steam generator through this method of inspections, however. some tube leakage problems were experienced in the past. To prevent recurrence of such events, government is conducting development and verification test program for new eddy current testing technology.

  6. Automated reticle inspection data analysis for wafer fabs

    Science.gov (United States)

    Summers, Derek; Chen, Gong; Reese, Bryan; Hutchinson, Trent; Liesching, Marcus; Ying, Hai; Dover, Russell

    2009-04-01

    To minimize potential wafer yield loss due to mask defects, most wafer fabs implement some form of reticle inspection system to monitor photomask quality in high-volume wafer manufacturing environments. Traditionally, experienced operators review reticle defects found by an inspection tool and then manually classify each defect as 'pass, warn, or fail' based on its size and location. However, in the event reticle defects are suspected of causing repeating wafer defects on a completed wafer, potential defects on all associated reticles must be manually searched on a layer-by-layer basis in an effort to identify the reticle responsible for the wafer yield loss. This 'problem reticle' search process is a very tedious and time-consuming task and may cause extended manufacturing line-down situations. Often times, Process Engineers and other team members need to manually investigate several reticle inspection reports to determine if yield loss can be tied to a specific layer. Because of the very nature of this detailed work, calculation errors may occur resulting in an incorrect root cause analysis effort. These delays waste valuable resources that could be spent working on other more productive activities. This paper examines an automated software solution for converting KLA-Tencor reticle inspection defect maps into a format compatible with KLA-Tencor's Klarity Defect(R) data analysis database. The objective is to use the graphical charting capabilities of Klarity Defect to reveal a clearer understanding of defect trends for individual reticle layers or entire mask sets. Automated analysis features include reticle defect count trend analysis and potentially stacking reticle defect maps for signature analysis against wafer inspection defect data. Other possible benefits include optimizing reticle inspection sample plans in an effort to support "lean manufacturing" initiatives for wafer fabs.

  7. Radioisotope flaw detection during the inspection of the NPS equipment

    International Nuclear Information System (INIS)

    The radioisotope method for non-destructive inspection is widely used in the USSR because of its specific features and advantages, namely, the possibility to inspect the items made of various materials, with a wide range of thickness, or located in places access to which is difficult, in the case of absence of power supply, under the effect of high level radiation background, etc. The methods and means of radioisotope flaw detection are used for the following fields of nuclear power engineering: inspection of the equipments during the scheduled preventive and major repairs of nuclear power stations (NPS); during the mounting and assembling of nuclear reactors; and during the manufacture of NPS equipments on the shop scale. Some features and specifications of such facilities are described briefly. The All-Union Scientific Research Institute of Radiation Engineering carries out the investigations connected not only with the apparatuses for flaw detection, but also with their effective applications. As the results of the performed investigations, a method of optimizing instrumental parameters based on the sensitivity and expense, the influence of different factors upon the selected criteria, the radiation exposure dose rate, etc., were suggested. It must be noted that the economical effect produced by the optimization of the technical characteristics of the instruments intended for the inspection has been obtained, as a rule, without additional capital expenses. (Wakatsuki, Y.)

  8. Turbine rotors inspection problems associated with independent inspection

    International Nuclear Information System (INIS)

    As is well know, the serious problems affecting turbine-generator set rotors and moving parts, such as stress-corrosion cracking and/or the phenomena of creep/fatigue, have led the companies possessing these components to make considerable investments in terms of economy and human resources with a view to finding means for control and solutions. The fact that certain countries, such as Spain, have a limited number of fossil-fuelled and/or nuclear plants, with different suppliers and designs, means that the control and solving of such problems necessarily imply significant technological dependence and, consequently, that the resources used imply high associated costs that is most cases have to be paid in overseas currencies. This fact led several Spanish plant owners to propose that Tecnatom carry out an R ampersand D project aimed at developing and integral turbine rotor inspection and evaluation system designed to reduce technological dependence in this area through the application of in-house technology. This project identified as PC-850059 has been subsidized by the Spanish authorities through The Interministerial Commission of Science ampersand Technology. This article describes the developments achieved and the difficulties inherent to independent turbine rotor inspection and evaluation

  9. RPII Inspection and Licensing Activities and Annual Inspection Programme for 2013

    International Nuclear Information System (INIS)

    The objective of this report is to provide an overview of inspection activities of the Radiological Protection Institute of Ireland RPII, to examine the evolution in licensee numbers and to outline the rationale in developing annual inspection programmes. All inspection activities are now carried out within the framework of a quality management system including inspection planning, the training of inspectors, the conduct of inspections as well as post inspection follow up and review. This report also provides an overview of the main features of the quality system

  10. Investigations of Potential Phenotypes of Foot Osteoarthritis: Cross‐Sectional Analysis From the Clinical Assessment Study of the Foot

    Science.gov (United States)

    Marshall, Michelle; Thomas, Martin J.; Menz, Hylton B.; Myers, Helen L.; Thomas, Elaine; Downes, Thomas; Peat, George; Roddy, Edward

    2016-01-01

    Objective To investigate the existence of distinct foot osteoarthritis (OA) phenotypes based on pattern of joint involvement and comparative symptom and risk profiles. Methods Participants ages ≥50 years reporting foot pain in the previous year were drawn from a population‐based cohort. Radiographs were scored for OA in the first metatarsophalangeal (MTP) joint, first and second cuneometatarsal, navicular first cuneiform, and talonavicular joints according to a published atlas. Chi‐square tests established clustering, and odds ratios (ORs) examined symmetry and pairwise associations of radiographic OA in the feet. Distinct underlying classes of foot OA were investigated by latent class analysis (LCA) and their association with symptoms and risk factors was assessed. Results In 533 participants (mean age 64.9 years, 55.9% female) radiographic OA clustered across both feet (P < 0.001) and was highly symmetrical (adjusted OR 3.0, 95% confidence interval 2.1, 4.2). LCA identified 3 distinct classes of foot OA: no or minimal foot OA (64%), isolated first MTP joint OA (22%), and polyarticular foot OA (15%). After adjustment for age and sex, polyarticular foot OA was associated with nodal OA, increased body mass index, and more pain and functional limitation compared to the other classes. Conclusion Patterning of radiographic foot OA has provided insight into the existence of 2 forms of foot OA: isolated first MTP joint OA and polyarticular foot OA. The symptom and risk factor profiles in individuals with polyarticular foot OA indicate a possible distinctive phenotype of foot OA, but further research is needed to explore the characteristics of isolated first MTP joint and polyarticular foot OA. PMID:26238801

  11. Visual Inspection for Caries Detection

    DEFF Research Database (Denmark)

    Gimenez, T; Piovesan, C; Braga, M M;

    2015-01-01

    We aimed to perform a systematic review including a meta-analysis to evaluate the overall accuracy of visual methods for detecting carious lesions and to identify possible sources of heterogeneity among the studies included. Two reviewers searched PubMed, Embase, Scopus, and other sources through...... July 2014 to identify published and nonpublished studies in English. Studies of visual inspection were included that 1) assessed accuracy of the method in detecting caries lesions; 2) were performed on occlusal, proximal, or free smooth surfaces in primary or permanent teeth; 3) had a reference...

  12. Quality Inspection of Printed Texts

    DEFF Research Database (Denmark)

    Pedersen, Jesper Ballisager; Nasrollahi, Kamal; Moeslund, Thomas B.

    2016-01-01

    -folded: for costumers of the printing and verification system, the overall grade used to verify if the text is of sufficient quality, while for printer's manufacturer, the detailed character/symbols grades and quality measurements are used for the improvement and optimization of the printing task. The......Inspecting the quality of printed texts has its own importance in many industrial applications. To do so, this paper proposes a grading system which evaluates the performance of the printing task using some quality measures for each character and symbols. The purpose of these grading system is two...

  13. Instant Adobe Edge Inspect starter

    CERN Document Server

    Khan, Joseph

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This easy-to-understand Starter guide will get you up to speed with Adobe Edge Inspect quickly and with little effort.This book is for frontend web developers and designers who are developing and testing web applications targeted for mobile browsers. It's assumed that you have a basic understanding of creating web applications using HTML, CSS, and JavaScript, as well as being familiar with running web pages from local HTTP servers. Readers are a

  14. Investigation on a focus of human trichinellosis revealed by an atypical clinical case after wild-boar (Sus scrofa pork consumption in northern Italy

    Directory of Open Access Journals (Sweden)

    Romano F.

    2011-02-01

    Full Text Available Trichinellosis is one of the most serious foodborne parasitic zoonoses in Europe. Wild carnivorous and omnivorous hosts are the main reservoirs of Trichinella spp. nematodes in nature. In the winter of 2008-2009, an atypical clinical case of trichinellosis occurred for the consumption of pork from a wild boar (Sus scrofa hunted in southwestern Alps in Italy. The symptomatic individual showed delayed development of oedemas in the lower limbs and eosinophilia, which appeared three months after infection. Muscle samples harboured 3.8 larvae/g, which were identified as Trichinella britovi. During the epidemiological investigation, anti-Trichinella IgG were detected in five hunters.

  15. Safety and Inspection Planning of Older Installations

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Ersdal, G.

    2008-01-01

    A basic assumption often made in risk- and reliability-based inspection planning is that a Bayesian approach can be used. This implies that probabilities of failure can be updated in a consistent way when new information (from inspections and repairs) becomes available. The Bayesian approach and a...... (and coalescence of small cracks) and increased crack growth. This should imply shorter inspection time intervals for ageing structures. Different approaches for updating inspection plans for older installations are proposed. The most promisingmethod consists of increasing the rate of crack initiations...... at the end of the expected lifetime - corresponding to a bath-tub hazard rate effect. The approach illustrated is for welded steel details in platforms. Systems effects are considered, including the use of dependence between inspection and failure events in different components for inspection...

  16. System for inspection of stacked cargo containers

    Science.gov (United States)

    Derenzo, Stephen

    2011-08-16

    The present invention relates to a system for inspection of stacked cargo containers. One embodiment of the invention generally comprises a plurality of stacked cargo containers arranged in rows or tiers, each container having a top, a bottom a first side, a second side, a front end, and a back end; a plurality of spacers arranged in rows or tiers; one or more mobile inspection devices for inspecting the cargo containers, wherein the one or more inspection devices are removeably disposed within the spacers, the inspection means configured to move through the spacers to detect radiation within the containers. The invented system can also be configured to inspect the cargo containers for a variety of other potentially hazardous materials including but not limited to explosive and chemical threats.

  17. Principles for National Inspections under IS Environment

    International Nuclear Information System (INIS)

    In 1997 the ROK introduced 'National Inspection' for nuclear material accountancy in its territory, and continues its independent verification activities besides the IAEA inspections. In 2004 the Additional Protocol was effectuated, and the IAEA finally decided to apply Integrated Safeguard to the ROK in 2008. This was a very significant milestone for Korea's nuclear transparency, which means that there are only nuclear activities with peaceful purposes and no more undeclared or suspicious nuclear activities. With this turning point, the previous inspection activities . IAEA and national inspections all together are to be adjusted to the new environment, i.e. Integrated Safeguards. Even for the SSAC, the objectives of national inspections are needed to be defined newly and its philosophy as well. In this paper, the principles of national inspections are suggested to address any verification challenges from the IS environment

  18. Inservice inspection of PFR secondary heat exchangers

    International Nuclear Information System (INIS)

    The author describes the current state of development to meet inservice inspection requirements of secondary heat exchangers of a prototype fast reactor: detection of defects in both the bore and outer surface of the tubes (pitting and cracking in the bore surface and fretting and thinning on the outer), full inspection of bends and straight portions, examination of the tube plate and of the tube/tube plate weld region. He reports the development of an eddy current probe for the in-service inspection (ISI) of the stainless steel tubing in the super-heater and re-heater, describes the influence of sodium concentration on eddy current inspection, and briefly evokes the detection of defects in bends. He describes the eddy current inspection of the evaporator tube bores, the wall thickness measurement in evaporator tubes. Then, he reports the in-service inspection of tube plates: tube bore examination, volumetric examination. He briefly discusses the obtained results

  19. Calculation of frequency of optimal inspection in non-notice inspection game

    International Nuclear Information System (INIS)

    We consider a non-notice inspection game between an inspection party, who verifies absence of diversion of nuclear materials and misuse of nuclear facility, and a facility operator, who tries them in a nuclear facility. In the game, the payoff for each player, inspection party and facility operator, is composed of various elements (parameters) such as facility type, a type of nuclear material, number of inspection and others. Their payoffs consist of profits and costs (minus profit). Because of random nature by non-notice inspection, its deterrence effect and inspection number could have the potential to affect their payoffs. In this paper, their payoffs taking into consideration of the inspection environment above are represented as a function of inspection number. Then, the optimal number is calculated from a condition on their payoffs for number of inspection. Comparable statics analysis is performed in order to observe the change of inspection number which is equilibrium point by changing these parameters including deterrence effect, because the number derived depends on each parameter within the inspection environment. Based on the analysis results, necessary conditions to reduce the inspection number keeping inspection effect are pointed out. (author)

  20. Epidemiologic and economic evaluation of risk-based meat inspection for bovine cysticercosis in Danish cattle

    DEFF Research Database (Denmark)

    Calvo Artavia, Francisco Fernando; Nielsen, Liza Rosenbaum; Alban, L.

    2013-01-01

    simulation model for analysis of tentative risk-based meat inspection systems for BC in Danish cattle with regard to system sensitivity (SSSe), specificity and potential monetary benefits compared to the current system, which has an estimated SSSe of 15%. The relevant risk factors used to construct three...... slaughterline, allowing them to do with one meat inspector less. All abattoirs would gain on the price of sold uncut beef from the masseter muscles from visually inspected cattle. Under these assumptions, using gender and grazing were preferable due to them having SSSe only slightly lower than the current...... the current meat inspection and under the investigated risk-based meat inspection systems. Therefore, improving the sensitivity of the methods used for inspection of high-risk cattle would be beneficial....

  1. Preoperative functional magnetic resonance tomography (fMRI) in patients with rolandic brain tumors: indication, investigation strategy, possibilities and limitations of clinical application

    International Nuclear Information System (INIS)

    Preoperative functional magnetic resonance imaging (fMRI) localizes the primary motor and somatosensory cortex in relation to rolandic brain tumors and determines plastic cortical reorganization. Functional landmarks help to assess the indication for surgery and to plan for safer surgical procedures that protect the functional cortex during resection even when morphologic landmarks are no longer identifiable on anatomic images. Despite its successful application, preoperative fMRI has not yet reached the status of an established clinical diagnostic procedure since special stimulation systems, standardized fMRI protocols and medically approved software are still lacking. Following a brief review of the image display of the functional and morphologic anatomy, the different indications for preoperative fMRI in patients with rolandic brain tumors are presented. A robust preoperative protocol enables clinical MR units with magnetic field strengths of 1.0 Tesla or higher to perform reliable fMRI during contralateral hand movements. Optimized investigation strategies and stimulation modalities are proposed for patients with rolandic tumors distant from the cortical hand representation, for patients with preexisting sensorimotor deficits and for patients with poor compliance. Representative cases illustrate the clinical application. Possibilities and limitations of preoperative fMRI are presented and discussed. (orig.)

  2. Main consiration of investigational new drug clinical evaluaion%新药临床试验申请评价基本考虑

    Institute of Scientific and Technical Information of China (English)

    钱思源; 王涛

    2015-01-01

    临床试验是创新药物研发的核心,因为药物的有效性和安全性最终都是依靠药物临床试验来进行检验的。本文从新药临床试验的评价模式、新药临床申请评价的内容、新药临床试验评价中的考虑要点和决策四个方面论述了当前国家食品药品监督管理总局药品审评中心对于新药临床试验申请的思考方向。%Clinical trials are the core of new drug, because efficacy and safety of new drug depends on clinical trials finally.This paper include four contents: evaluation mode of investigational new drug ( IND ) , contents of IND, main points of IND and strategic decision.This paper discusses the current direction of thinking on China Food and Drug Administration Center for Drug Evaluation application for clinical trial.

  3. Safety and Inspection Planning of Older Installations

    OpenAIRE

    Sørensen, John Dalsgaard; Ersdal, G.

    2008-01-01

    A basic assumption often made in risk- and reliability-based inspection planning is that a Bayesian approach can be used. This implies that probabilities of failure can be updated in a consistent way when new information (from inspections and repairs) becomes available. The Bayesian approach and a no-crack detection assumption imply that the inspection time intervals usually become longer and longer with time. For ageing platforms several small cracks should be expected to be observed accordi...

  4. Remote ultrasonic inspection of Magnox reactor standpipes

    International Nuclear Information System (INIS)

    Although Magnox reactor standpipes are not subjected to routine in-service examination, it is occassionally necessary to inspect them for potential problems. Checks on wall thickness, weld integrity and the condition of inaccessible surfaces are made using remote ultrasonic immersion techniques from the bore. Special manipulators with rugged, inflatable seals allow the inspection zones to be completely flooded. The immersion technique has proved a reliable and safe method of inspection. Several of these applications are described. (author)

  5. AECL experience in fuel channel inspection

    International Nuclear Information System (INIS)

    Inspection of CANDU fuel channels (FC) is performed to ensure safe and economic reactor operation. CANDU reactor FCs have features that make them a unique non-destructive testing (NDT) challenge. The thin, 4 mm pressure-tube wall means flaws down to about 0.1 mm deep must be reliably detected and characterized. This is one to two orders of magnitude smaller than is usually considered of significant concern for steel piping and pressure vessels. A second unique feature is that inspection sensors must operate in the reactor core--often within 20 cm of highly radioactive fuel. Work on inspection of CANDU reactor FCs at AECL dates back over three decades. In that time, AECL staff have provided equipment and conducted or supervised in-service inspections in about 250 FCs, in addition to over 8000 pre-service FCs. These inspections took place at every existing CANDU reactor except those in India and Romania. Early FC inspections focussed on measurement of changes in dimensions (gauging) resulting from exposure to a combination of neutrons, stress and elevated temperature. Expansion of inspection activities to include volumetric inspection (for flaws) started in the mid-1970s with the discovery of delayed hydride cracking in Pickering 3 and 4 rolled joints. Recognition of other types of flaw mechanisms in the 1980s led to further expansion in both pre-service and in-service inspections. These growing requirements, to meet regulatory as well as economic needs, led to the development of a wide spectrum of inspection technology that now includes tests for hydrogen concentration, structural integrity of core components, flaws, and dimensional change. This paper reviews current CANDU reactor FC inspection requirements. The equipment and techniques developed to satisfy these requirements are also described. The paper concludes with a discussion of work in progress in AECL aimed at providing state-of-the-art FC inspection services. (author)

  6. Visual inspection. Better than your eyes

    International Nuclear Information System (INIS)

    Ongoing improvements in the development of camera technologies and manipulator techniques permit an enhanced performance of inspection tasks in nuclear services. In areas of reduced dose rate it's possible to use small size high resolution CCD cameras instead of tube cameras. Underwater inspections may be performed by submarine instead of rigid manipulator systems. This allows the enlargement of inspection areas and the performance at reduced time and personnel dose rate. (author)

  7. Periodic inspections of the primary system

    International Nuclear Information System (INIS)

    An impression is given of the inspection techniques, preparations and background for periodic examinations of the primary system of the Dodewaard Nuclear Reactor over the past 10 years. Unfortunately reliable integral inspection techniques to enable 'listening-in' to developing faults, are not yet available. Until they are, inspections will continue to be executed from a distance using different continuous methods, often under water and with a shortage of space and in the presence of ionising radiations. (C.F.)

  8. User interface inspection methods a user-centered design method

    CERN Document Server

    Wilson, Chauncey

    2014-01-01

    User Interface Inspection Methods succinctly covers five inspection methods: heuristic evaluation, perspective-based user interface inspection, cognitive walkthrough, pluralistic walkthrough, and formal usability inspections. Heuristic evaluation is perhaps the best-known inspection method, requiring a group of evaluators to review a product against a set of general principles. The perspective-based user interface inspection is based on the principle that different perspectives will find different problems in a user interface. In the related persona-based inspection, colleagues assume the

  9. China's coal export and inspection

    International Nuclear Information System (INIS)

    With the development of world's business and trade, coal has become a large part of the import and export goods in the international market. The total amount of coal trade has risen a lot. China is rich in coal resources. According to the estimate made by some experts, the reserve which has been explored recently could be exploited hundreds of years. China's output of raw coal has risen a lot during the past forty years. China coal industry has developed rapidly since the 1980s. It is possible for China to become a big coal export country since it has rich resources and increasing output. The paper suggests four steps which must be taken to expand coal exports in China: improve the level of management and administration of coal mines so as to raise the economic benefit; the follow-up production capacity of the present mines must be enhanced rapidly; step up construction of new large-scale mines; and China's coal washing capacity must be improved speedily since the low capacity has seriously influenced the improvement of coal quality. The paper describes the inspection bureaus and companies that have developed to perform inspection of exports in order to guarantee the quality of export coal

  10. Investigation of occult hepatitis B virus infection in anti-hbc positive patients from a liver clinic.

    Directory of Open Access Journals (Sweden)

    Maria Carmela Martinez

    Full Text Available Occult hepatitis B infection (OBI is manifested by presence of very low levels (<200IU/mL of Hepatitis B viral DNA (HBV DNA in the blood and the liver while exhibiting undetectable HBV surface antigen (HBsAg. The molecular mechanisms underlying this occurrence are still not completely understood. This study investigated the prevalence of OBI in a high-risk Australian population and compared the HBV S gene sequences of our cohort with reference sequences. Serum from HBV DNA positive, HBsAg negative, and hepatitis B core antibody (anti-HBc positive patients (study cohort were obtained from samples tested at SEALS Serology Laboratory using the Abbott Architect, as part of screening and diagnostic testing. From a total of 228,108 samples reviewed, 1,451 patients were tested for all three OBI markers. Only 10 patients (0.69% out of the 1,451 patients were found to fit the selection criteria for OBI. Sequence analysis of the HBV S gene from 5 suspected OBI infected patients showed increased sequence variability in the 'a' epitope of the major hydrophilic region compared to reference sequences. In addition, a total of eight consistent nucleotide substitutions resulting in seven amino acid changes were observed, and three patients had truncated S gene sequence. These mutations appeared to be stable and may result in alterations in HBsAg conformation. These may negatively impact the affinity of hepatitis B surface antibody (anti-HBs and may explain the false negative results in serological HBV diagnosis. These changes may also enable the virus to persist in the liver by evading immune surveillance. Further studies on a bigger cohort are required to determine whether these amino acid variations have been acquired in the process of immune escape and serve as markers of OBI.

  11. Non-Destructive Inspection Lab (NDI)

    Data.gov (United States)

    Federal Laboratory Consortium — The NDI specializes in applied research, development and performance of nondestructive inspection procedures (flourescent penetrant, magnetic particle, ultrasonics,...

  12. Periodic and in-service inspection programs

    International Nuclear Information System (INIS)

    Periodic and in-service inspection programs for Cernavoda NPP consists of periodic inspections of CANDU NPP components CSAN N-285.4 and CSAN N-285.4, in-service inspections and repair and modifications general inspection. Periodic inspection program document (PIPD) determines the systems and components subject to inspection, the category of the inspection, techniques, areas and other details.The current status of the inspection programs is presented, including containment , erosion/corrosion, pressure vessel support and snubbers, main steam lines inspection programs. Qualification program in Cernavoda NPP involves equipment qualification in the on-site laboratory, yearly certification, special equipment qualification in the National Institute of Metrology. All procedures are approved by the ISCIR (regulatory body for pressure vessel and lifting equipment) and CNCAN (National Commission on Nuclear Activities Control). Qualification of the personnel is performed according to the ISCIR Technical prescription CR 11/82 for up to 3 year period. Final qualification and licensing is performed by CNCAN

  13. Computer vision technology in log volume inspection

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Log volume inspection is very important in forestry research and paper making engineering. This paper proposed a novel approach based on computer vision technology to cope with log volume inspection. The needed hardware system was analyzed and the details of the inspection algorithms were given. A fuzzy entropy based on image enhancement algorithm was presented for enhancing the image of the cross-section of log. In many practical applications the cross-section is often partially invisible, and this is the major obstacle for correct inspection. To solve this problem, a robust Hausdorff distance method was proposed to recover the whole cross-section. Experiment results showed that this method was efficient.

  14. Development of an automatic reactor inspection system

    International Nuclear Information System (INIS)

    Using recent technologies on a mobile robot computer science, we developed an automatic inspection system for weld lines of the reactor vessel. The ultrasonic inspection of the reactor pressure vessel is currently performed by commercialized robot manipulators. Since, however, the conventional fixed type robot manipulator is very huge, heavy and expensive, it needs long inspection time and is hard to handle and maintain. In order to resolve these problems, we developed a new automatic inspection system using a small mobile robot crawling on the vertical wall of the reactor vessel. According to our conceptual design, we developed the reactor inspection system including an underwater inspection robot, a laser position control subsystem, an ultrasonic data acquisition/analysis subsystem and a main control subsystem. We successfully carried out underwater experiments on the reactor vessel mockup, and real reactor ready for Ulchine nuclear power plant unit 6 at Dusan Heavy Industry in Korea. After this project, we have a plan to commercialize our inspection system. Using this system, we can expect much reduction of the inspection time, performance enhancement, automatic management of inspection history, etc. In the economic point of view, we can also expect import substitution more than 4 million dollars. The established essential technologies for intelligent control and automation are expected to be synthetically applied to the automation of similar systems in nuclear power plants

  15. Quality assurance for IAEA inspection planning

    International Nuclear Information System (INIS)

    Under the provisions of the Treaty on Nonproliferation of Nuclear Weapons and other agreements with states, the International Atomic Energy Agency (IAEA) conducts inspections at nuclear facilities to confirm that their operation is consistent with the peaceful use of nuclear material. The Department of Safeguards at the IAEA is considering a quality assurance program for activities related to the planning of these facility inspections. In this report, we summarize recent work in writing standards for planning inspections at the types of facilities inspected by the IAEA. The standards specify the sequence of steps in planning inspections, which are: (1) administrative functions, such as arrangements for visas and travel, and communications with the state to confirm facility operating schedules and the state's acceptance of the assigned inspectors; (2) technical functions including a specification of the required inspection activities, determination of personnel and equipment resources, and a schedule for implementing the inspection activities at the facility; and (3) management functions, such as pre- and post-inspection briefings, where the planned and implemented inspection activities are reviewed

  16. ENIQ: European Network for Inspection Qualification

    International Nuclear Information System (INIS)

    Many countries are currently considering their own approach to inspection qualification and are carefully assessing experience to date. ENIQ, which stands for European Network for Inspection Qualification, groups the major part of the utilities in Western Europe. The general objective of ENIQ is to coordinate and manage at European level expertise and resources for the assessment and qualification of NDE inspection techniques and procedures, primarily for nuclear components. Also non-nuclear heavy duty components will be considered. Within ENIQ there is a growing consensus of opinion on the general principles of a European approach towards inspection qualification. In this paper the main activities, organization and actual status of ENIQ will be discussed

  17. Optics damage inspection for the NIF

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, C. E., LLNL

    1998-06-01

    Two optics damage inspection systems will be implemented on the National Ignition Facility (NIF), one to inspect optics within the laser and transport sections and the other to inspect the final optics at the target chamber. Both systems use dark-field imaging technology to enhance resolution of defects. Details of each system design will be provided. A functional optics damage inspection system prototype, using dark-field imaging technology, is currently in operation on the Beamlet laser. This system provides us with the opportunity to measure non-ideal optical surfaces expected to be present on NIF. Prototype details and performance will be presented.

  18. Robotic inspection technology-process an toolbox

    Energy Technology Data Exchange (ETDEWEB)

    Hermes, Markus [ROSEN Group (United States). R and D Dept.

    2005-07-01

    Pipeline deterioration grows progressively with ultimate aging of pipeline systems (on-plot and cross country). This includes both, very localized corrosion as well as increasing failure probability due to fatigue cracking. Limiting regular inspecting activities to the 'scrapable' part of the pipelines only, will ultimately result into a pipeline system with questionable integrity. The confidence level in the integrity of these systems will drop below acceptance levels. Inspection of presently un-inspectable sections of the pipeline system becomes a must. This paper provides information on ROSEN's progress on the 'robotic inspection technology' project. The robotic inspection concept developed by ROSEN is based on a modular toolbox principle. This is mandatory. A universal 'all purpose' robot would not be reliable and efficient in resolving the postulated inspection task. A preparatory Quality Function Deployment (QFD) analysis is performed prior to the decision about the adequate robotic solution. This enhances the serviceability and efficiency of the provided technology. The word 'robotic' can be understood in its full meaning of Recognition - Strategy - Motion - Control. Cooperation of different individual systems with an established communication, e.g. utilizing Bluetooth technology, support the robustness of the ROSEN robotic inspection approach. Beside the navigation strategy, the inspection strategy is also part of the QFD process. Multiple inspection technologies combined on a single carrier or distributed across interacting container must be selected with a clear vision of the particular goal. (author)

  19. Analytical investigations of toxic p-phenylenediamine (PPD levels in clinical urine samples with special focus on MALDI-MS/MS.

    Directory of Open Access Journals (Sweden)

    Gero P Hooff

    Full Text Available Para-phenylenediamine (PPD is a common chromophoric ingredient in oxidative hair-dyes. In some African countries like Sudan, Egypt and Morocco but also in India this chemical is used alone or in combination with colouring extracts like Henna for dyeing of the hair or the skin. Excessive dermal exposure to PPD mainly leads to the N-mono- and N,N'-diacetylated products (MAPPD, DAPPD by N-acetyltransferase 1 and 2 (NAT1 and 2 catalyzed reactions. Metabolites and PPD are mainly excreted via renal clearance. Despite a low risk of intoxication when used in due form, there are numerous cases of acute intoxication in those countries every year. At the ENT Hospital - Khartoum (Sudan alone more than 300 cases are reported every year (~10% fatal, mostly caused by either an accidental or intended (suicidal high systemic exposure to pure PPD. Intoxication leads to a severe clinical syndrome including laryngeal edema, rhabdomyolysis and subsequent renal failure, neurotoxicity and acute toxic hepatitis. To date, there is no defined clinical treatment or antidote available and treatment is largely supportive. Herein, we show the development of a quick on-site identification assay to facilitate differential diagnosis in the clinic and, more importantly, the implementation of an advanced analytical platform for future in-depth investigations of PPD intoxication and metabolism is described. The current work shows a sensitive (~25 µM wet chemistry assay, a validated MALDI-MS/MS and HPLC-UV assay for the determination of PPD and its metabolites in human urine. We show the feasibility of the methods for measuring PPD over a range of 50-1000 µM. The validation criteria included linearity, lower limit of quantification (LLOQ, accuracy and precision, recovery and stability. Finally, PPD concentrations were determined in clinical urine samples of cases of acute intoxication and the applied technique was expanded to identify MAPPD and DAPPD in the identical samples.

  20. Clinical, molecular and functional investigation on an infant with neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD.

    Directory of Open Access Journals (Sweden)

    Zhan-Hui Zhang

    Full Text Available BACKGROUND AND OBJECTIVE: SLC25A13 analysis has provided reliable evidences for the definitive diagnosis of citrin deficiency (CD in the past decade. Meanwhile, these studies generated some issues yet to be resolved, including the pathogenicity of SLC25A13 missense mutations and the mRNA product from the mutation c.615+5G>A. This study aims to investigate the effect of a novel missense mutation on the aspartate/glutamate carrier (AGC function of citrin protein, and to explore the aberrant transcript from c.615+5G>A in the same CD infant. METHODS AND RESULTS: By means of screening for prevalent SLC25A13 mutations and exons sequencing, the patient proved a compound heterozygote of c.615+5G>A and a novel c.1064G>A (p.Arg355Gln mutation. An aberrant transcript with retention of the entire intron 6, r.[615+1_615+1789ins; 615+5 g>a] (GenBank accession number KJ128074, which was resulted from c.615+5G>A, was detected by RT-PCR and cDNA sequencing. After bioinformatic analyses of the novel missense mutation c.1064G>A, the growth abilities of three agc1Δ yeast strains were tested, which had been transformed with recombinant or empty vectors, respectively. Besides the bioinformatically pathogenic evidences, the growth ability of the agc1Δ strains transformed with mutant recombinant was the same as with empty vector, but significantly lower than that with normal control in functional analysis. CONCLUSIONS: A CD infant was definitely diagnosed in this paper by a genetic, transcriptional and functional analysis of SLC25A13 gene. This study provided direct laboratory evidences supporting the splice-site nature of the c.615+5G>A mutation, and the novel c.1064G>A variation, which proved a pathogenic mutation bioinformatically and functionally, enriched the SLC25A13 mutation spectrum.

  1. Teaching Translational Research to Medical Students: The New York University School of Medicine's Master's of Science in Clinical Investigation Dual-Degree Program.

    Science.gov (United States)

    Gillman, Jennifer; Pillinger, Michael; Plottel, Claudia S; Galeano, Claudia; Maddalo, Scott; Hochman, Judith S; Cronstein, Bruce N; Gold-von Simson, Gabrielle

    2015-12-01

    To develop the next generation of translational investigators, New York University School of Medicine (NYUSOM) and the NYU-NYC Health and Hospitals Corporation Clinical and Translational Science Institute (NYU-HHC CTSI) developed the Master's of Science in Clinical Investigation dual-degree (MD/MSCI) program. This 5-year program dedicates 1 year to coursework and biomedical research, followed by a medical school/research overlap year, to prepare students for academic research careers. This paper details the MD/MSCI program's curriculum and approach to mentorship, describes the research/professional interests of students, and reports student productivity. In the first 4 years of the program (2010-2014) 20 students were matriculated; 7 (35%) were women, and 12 (60%) research projects were in surgical specialties. To date, 14 students have applied to residency, and half pursued surgical residency programs. Our students have produced 68 accepted abstracts, 15 abstracts in submission, 38 accepted papers, and 24 papers in submission. Despite the time-limited nature of this program, additional training in research design and implementation has promoted a high level of productivity. We conclude that dual-degree training in medicine and translational research is feasible for medical students and allows for meaningful participation in valuable projects. Follow-up is warranted to evaluate the academic trajectory of these students. PMID:26365704

  2. Definition of preclinical and clinical character of human symptomatic status by quasi-elastic light scattering (QELS) investigations of blood plasma

    Science.gov (United States)

    Ivanova, Mariya A.; Klopov, Nicolay V.; Lebedev, Andrei D.; Noskin, Leonid A.; Noskin, Valentin A.; Pavlov, Michail Y.

    1997-05-01

    We discuss the use of the QELS method for screening of population groups for verified pathologies. For mathematical analysis of experimental data the regularization procedure have been used. This allows us to determine the histograms of particle size distribution of blood plasma samples. For the interpretation of the histogram data the special program of the mathematical processing - 'semiotic classifier' - have been created. The main idea of the 'semiotic classifier' is based on the fact, that formation of the pathological trace in human organism depends not only on concrete disease nature but also on the interaction between the organism sanogenetic mechanisms. We separate five pathological symptomatic complexes of organism status: allergic diseases, intoxications, organism catabolic shifts, auto-immune diseases and degenerative-dystrophy processes. The use of this 'semiotic classifier' in the system of monitoring investigations allows to solve the next problems: (1) to separate the persons with the expressed initial level of pathological processes to the risk groups for the special clinical investigations, (2) to set up the predisposition of the concrete individual towards definite pathologies at the preclinical stage, (3) under the conditions of expressed clinical pathology to study the dynamics of pathology processes.

  3. The challenges and opportunities of conducting a clinical trial in a low resource setting: The case of the Cameroon mobile phone SMS (CAMPS trial, an investigator initiated trial

    Directory of Open Access Journals (Sweden)

    Ongolo-Zogo Pierre

    2011-06-01

    Full Text Available Abstract Conducting clinical trials in developing countries often presents significant ethical, organisational, cultural and infrastructural challenges to researchers, pharmaceutical companies, sponsors and regulatory bodies. Globally, these regions are under-represented in research, yet this population stands to gain more from research in these settings as the burdens on health are greater than those in developed resourceful countries. However, developing countries also offer an attractive setting for clinical trials because they often have larger treatment naive populations with higher incidence rates of disease and more advanced stages. These factors can present a reduction in costs and time required to recruit patients. So, balance needs to be found where research can be encouraged and supported in order to bring maximum public health benefits to these communities. The difficulties with such trials arise from problems with obtaining valid informed consent, ethical compensation mechanisms for extremely poor populations, poor health infrastructure and considerable socio-economic and cultural divides. Ethical concerns with trials in developing countries have received attention, even though many other non-ethical issues may arise. Local investigator initiated trials also face a variety of difficulties that have not been adequately reported in literature. This paper uses the example of the Cameroon Mobile Phone SMS trial to describe in detail, the specific difficulties encountered in an investigator-initiated trial in a developing country. It highlights administrative, ethical, financial and staff related issues, proposes solutions and gives a list of additional documentation to ease the organisational process.

  4. Automation of the radiosynthesis and purification procedures for [18F]Fluspidine preparation, a new radiotracer for clinical investigations in PET imaging of σ1 receptors in brain

    International Nuclear Information System (INIS)

    The radiosynthesis of [18F]Fluspidine, a potent σ1 receptor imaging probe for pre-clinical/clinical studies, was implemented on a TRACERlabTM FX F-N synthesizer. [18F]2 was synthesized in 15 min at 85 °C starting from its tosylate precursor. Purification via semi-preparative RP-HPLC was investigated using different columns and eluent compositions and was most successful on a polar RP phase with acetonitrile/water buffered with NH4OAc. After solid phase extraction, [18F]Fluspidine was formulated and produced within 59±4 min with an overall radiochemical yield of 37±8%, a radiochemical purity of 99.3±0.5% and high specific activity (176.6±52.0 GBq/µmol). - Highlights: • [18F]Fluspidine is a promising radiotracer for PET imaging of sigma1 receptors. • A fully automated CGMP-oriented radiosynthesis of [18F]Fluspidine is described. • The purification was investigated using different semi-preparative HPLC systems. • [18F]Fluspidine was produced within 59±4 min with a radiochemical yield of 37±8%

  5. An analysis of the demographic profile, clinical manifestations, investigations and outcome of paediatric myelodysplastic syndrome: A single centre, cross-sectional study

    Directory of Open Access Journals (Sweden)

    Appaji Lingegowda

    2015-09-01

    Full Text Available Purpose: Pediatric myelodysplastic syndrome (MDS is a relatively rare entity, with distinct clinical features and more aggressive course than its adult counterpart. The aim of this study was to analyze the incidence of pediatric myelodysplastic syndrome at a tertiary cancer care center in southern India along with clinical manifestations, investigations and outcome.Methods: On retrospective analysis of 1094 cases of pediatric hematological malignancies over a five-year period from September 2009 to August 2014, a total of seven cases of pediatric myelodysplastic syndrome were identified. Presenting complaints, physical examination, investigations including haemogram, biochemistry, bone marrow examination and cytogenetics were reviewed. The diagnosis of MDS was made if there was dysplasia in at least 10% of cells in two or more cell lineages. All patients were risk stratified using the revised IPSS. Results: Out of 1094 cases of pediatric hematological malignancies presenting at our institute within the study period, there were only seven cases of pediatric MDS with an incidence of 0.65%. There were no genetic predispositions nor any cases of therapy related MDS. The most common presentation was with fever and all patients had significant splenomegaly. All patients had anemia (Median-6.2 gm / dL with elevated WBC counts (Median-30,900 / uL and thrombocytopenia (Median-50,000 / uL. The marrow cytogenetics was normal in five patients. Most patients fell into the high and very high-risk category of the revised IPSS, with only two patients of low risk. All seven patients were given only supportive care but one progressed to AML for which he was treated with remission induction. Only two patients were alive at the time of analysis and median survival was 9 months. Conclusion: Pediatric MDS is a rare disease with a short clinical history, aggressive course and generally poor outcomes as compared to the adult variant. A hematopoietic stem cell

  6. Combined Treatment of Large Hepatocellular Carcinoma with Transcatheter Arterial Chemoembolization and Percutaneous Ethanol Injection with a Multipronged Needle: Experimental and Clinical Investigation

    International Nuclear Information System (INIS)

    Purpose: This study was designed to evaluate the usefulness of percutaneous ethanol injection (PEI) with a multipronged needle for the treatment of large hepatocellular carcinoma (HCC). An experimental animal study and a clinical investigation were performed. Methods: In the experimental study, 20 ml of 99.5% ethanol was injected into porcine liver in vivo with a multipronged needle (n = 5) or a straight needle (n = 5), and the volumes of coagulation necrosis were compared. In the clinical investigation, PEI was performed in 17 patients (10 men, 7 women; mean age 73.4 ± 6.7 years) with single, large HCC (mean tumor diameter, 47.2 ± 11.5 mm; range, 32–70 mm) by using a multipronged needle. Fifteen of 17 patients received transarterial chemoembolization (TACE) before PEI. Results: The volume of coagulation in porcine liver in vivo was significantly increased with the multipronged needle compared with the straight needle (longest perpendicular diameters, 34.2 ± 3.6 mm × 30.2 ± 3.6 mm vs. 22.6 ± 2.5 mm × 19 ± 2.2 mm, respectively; P < 0.05). In the clinical trial, initial complete response (CR) of the tumor was achieved in 17 of 17 patients, 7 of whom required two PEI sessions. During the follow-up, local recurrence was detected in 4 of 17 patients at 3–19 months after the procedure, for a rate of sustained local CR of 76%. No major complication occurred. Conclusions: Use of a multipronged needle substantially increases the volume of coagulation in vivo with respect to the conventional PEI technique. Combined TACE and PEI with multipronged needles is a safe and effective option for percutaneous treatment of single, large HCC.

  7. Application of phased array techniques to coarse grain components inspection

    International Nuclear Information System (INIS)

    Ultrasonic inspection of cast stainless steel components from primary and auxiliary cooling circuits of 'French Nuclear Power Plant has to face with major difficulties due to the coarse grained structure of these materials. Attenuation losses and structural noise are encountered, which limits the performances of defect detection ability, mostly in terms of degraded signal-to-noise ratio and poor sensitivity. To overcome such problems, theoretical and experimental studies have been achieved at the French Atomic Energy Commission, with support from the French Institute for Radiological Protection and Nuclear Safety. Experimental studies have been performed over stainless steel specimen of known coarse structure (equi-axial grains and/or elongated grains), containing artificial reflectors (cylindrical holes and electro-eroded surface breaking notches). Those mock-ups have been inspected using contact probes of different array designs (linear or matrix splitting), and using pulse echo or dual-element techniques. Such arrays allow to control the ultrasonic beam so as to investigate different inspection angles and focusing depths. Experiments were carried out using oblique longitudinal waves, using delay laws computed by a specific model, taking account of acoustical and geometrical properties of the probes and the inspected component. In addition, specific reconstruction techniques have been investigated to enhance the signal-to-noise ratio as well as spatial resolution. These techniques are based on beam-forming summation and multi-angle inspections. Experimental results show that such techniques allow to reduce the speckle noise and to optimise the beam resolution. Those increased performances allow to detect and to size small planar defects located at the inner wall of a thick specimen, using corner and tip diffraction echoes. (authors)

  8. Nuclear data needs for non-intrusive inspection

    International Nuclear Information System (INIS)

    Various nuclear-based techniques are being explored for use in non-intrusive inspection. Their development is motivated by the need to prevent the proliferation of nuclear weapons, to thwart trafficking in illicit narcotics, to stop the transport of explosives by terrorist organizations, to characterize nuclear waste, and to deal with various other societal concerns. Non-intrusive methods are sought in order to optimize inspection speed, to minimize damage to packages and containers, to satisfy environmental, health and safety requirements, to adhere to legal requirements, and to avoid inconveniencing the innocent. These inspection techniques can be grouped into two major categories: active and passive. They almost always require the use of highly penetrating radiation and therefore are generally limited to neutrons and gamma rays. Although x-rays are widely employed for these purposes, their use does not constitute nuclear technology and therefore is not discussed here. This paper examines briefly the basic concepts associated with nuclear inspection and investigates the related nuclear data needs. These needs are illustrated by considering four of the methods currently being developed and tested

  9. Nuclear data needs for non-intrusive inspection

    International Nuclear Information System (INIS)

    Various nuclear-based techniques are being explored for use in non-intrusive inspection. Their development is motivated by the need to prevent the proliferation of nuclear weapons, to thwart trafficking in illicit narcotics, to stop the transport of explosives by terrorist organizations, to characterize nuclear waste, and to deal with various other societal concerns. Non-intrusive methods are sought in order to optimize inspection speed, to minimize damage to packages and containers, to satisfy environmental, health and safety requirements, to adhere to legal requirements, and to avoid inconveniencing the innocent. These inspection techniques can be grouped into two major categories: active and passive. They almost always require the use of highly penetrating radiation and therefore are generally limited to neutrons and gamma rays. Although x-rays are widely employed for these purposes, their use does not constitute 'nuclear technology' and therefore is not discussed here. This paper examines briefly the basic concepts associated with nuclear inspection and investigates the related nuclear data needs. These needs are illustrated by considering four of the methods currently being developed and tested. (author)

  10. Nuclear data needs for non-intrusive inspection.

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D. L.; Michlich, B. J.

    2000-11-29

    Various nuclear-based techniques are being explored for use in non-intrusive inspection. Their development is motivated by the need to prevent the proliferation of nuclear weapons, to thwart trafficking in illicit narcotics, to stop the transport of explosives by terrorist organizations, to characterize nuclear waste, and to deal with various other societal concerns. Non-intrusive methods are sought in order to optimize inspection speed, to minimize damage to packages and containers, to satisfy environmental, health and safety requirements, to adhere to legal requirements, and to avoid inconveniencing the innocent. These inspection techniques can be grouped into two major categories: active and passive. They almost always require the use of highly penetrating radiation and therefore are generally limited to neutrons and gamma rays. Although x-rays are widely employed for these purposes, their use does not constitute nuclear technology and therefore is not discussed here. This paper examines briefly the basic concepts associated with nuclear inspection and investigates the related nuclear data needs. These needs are illustrated by considering four of the methods currently being developed and tested.

  11. Deployment Plan for Small Roving Annulus Inspection Vehicle

    International Nuclear Information System (INIS)

    The Small Roving Annulus Inspection Vehicle (SRAIV) is a modified commercially available wall crawler designed to supplement the In-Service Inspection (ISI) of Savannah River Site (SRS) Waste tanks. The SRAIV provides an improved capability to achieve a more complete inspection of the tank walls than existing methods. The SRAIV will be deployed through annulus risers in the tank to gain access to tank walls requiring inspection. The SRAIV will be deployed using a manually operated deployment pole and will be coupled to the wall using permanent magnet wheels. Navigation will be performed from the remote console where pictorial views can be displayed from the on-board cameras. The unit will incorporate multiple UT transducers for traditional weld examination. In addition, a specially developed Tandem Synthetic Aperture Focusing Technique (TSAFT) UT scanning bridge can be attached to provide further investigation of the knuckle region while the vehicle remains on the vertical surface of the tank wall. In summary, the SRAIV will provide features that enhance and expand the capability of the SRS ISI program

  12. Full surface inspection methods regarding reinforcement corrosion of concrete structures

    International Nuclear Information System (INIS)

    For reinforced concrete structures a localisation of all significant critical areas can only be done by a full surface inspection. The economic advantages are obvious: uncritical areas have not to be repaired expensively.The first step of the assessment should always be a visual inspection. The range of deterioration causes can be limited and the degree of deterioration may be estimated roughly. The inspection program can be adjusted to the requirements. By means of a full surface potential mapping areas with a high risk for chloride induced reinforcement corrosion can be localised, although no deteriorations are visually detectable at the concrete surface. In combination with concrete cover depth and resistivity measurements areas with corrosion promoting exposure conditions can be localised even if the reinforcement is not yet de-passivated. The following publication gives an overview about the essential full surface investigation methods to localise critical areas regarding corrosion of steel in concrete. The selection of methods is based on the inspection procedure given in reference 2. (authors)

  13. The interactive on-site inspection system: An information management system to support arms control inspections

    Energy Technology Data Exchange (ETDEWEB)

    DeLand, S.M.; Widney, T.W.; Horak, K.E.; Caudell, R.B.; Grose, E.M.

    1996-12-01

    The increasing use of on-site inspection (OSI) to meet the nation`s obligations with recently signed treaties requires the nation to manage a variety of inspection requirements. This document describes a prototype automated system to assist in the preparation and management of these inspections.

  14. Optimizing in-service inspection

    International Nuclear Information System (INIS)

    In the present paper, the aspects of optimizing In-Service Inspection (ISI) is discussed. Slovenian Nuclear Safety Administration (SNSA) and its authorized organization for the ISI activities, Institute of Metals and Technologies, are permanently involved in the ISI process of the nuclear power plant (NPP) Krsko. Based on this experience and additionally gathered by reviewing of the new ISI program, the decision was made to improve recent regulatory and professional practice. Traditional criteria, standards and practice are bases for the further improvements. Improvements will be done by adding a new knowledge about the safety important components of the systems to the basic practice. It is necessary to identify conditions of the safety important components, such as realistic stress and fatigue conditions, material properties changes due aging processes, the temperature cycling effects, existing flaws characterization in the light of the previous detection and equipment technique used, assessment of the measurement accuracy on the results etc. In addition to the above mentioned, risk assessment and evaluation of the whole ISI shall be done. To do this it is necessary to make risk evaluation, based on previous structural element probability assessment. Probabilistic risk assessment is important and one of the most powerful tools in the ISI optimization. Some basic work in the field of the risk informed methods related to the nuclear safety components has been already done. Based on reference documentation, the most important steps in risk informed ISI are discussed. Those steps are scope definition, consequence evaluation, failure probability estimation, risk evaluation, nondestructive examination method selection and possibilities of implementation, monitoring and feedback. Recent experience on the ISI in the nuclear world show that such practice is very important during ISI decision making process and has some measurable effects too. It is clear that classical

  15. 49 CFR 230.32 - Time and method of inspection.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Time and method of inspection. 230.32 Section 230... Appurtenances Inspection and Repair § 230.32 Time and method of inspection. (a) Time of inspection. The entire... other components interfering with the provision of inspection access shall be removed at this...

  16. 46 CFR 160.064-6 - Examinations, tests and inspections.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Examinations, tests and inspections. 160.064-6 Section... Examinations, tests and inspections. (a) Manufacturer's inspection and tests. Manufacturers of listed and... upon request. (b) Laboratory inspections and tests. Such examinations, inspections and tests as...

  17. 46 CFR 164.012-13 - Examinations, tests, and inspections.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Examinations, tests, and inspections. 164.012-13 Section...-13 Examinations, tests, and inspections. (a) Manufacturer's inspection and tests. Manufacturers of... upon request. (b) Laboratory inspection and tests. Such examinations, inspections and tests as...

  18. Ultrasonic inspection of austenitic welds

    International Nuclear Information System (INIS)

    The ultrasonic examination of austenitic stainless steel weld metal has always been regarded as a difficult proposition because of the large and variable ultrasonic attenuations and back scattering obtained from apparently similar weld deposits. The work to be described shows how the existence of a fibre texture within each weld deposit (as a result of epitaxial growth through successive weld beads) produces a systematic variation in the ultrasonic attenuation coefficient and the velocity of sound, depending upon the angle between the ultrasonic beam and the fibre axis. Development work has shown that it is possible to adjust the welding parameters to ensure that the crystallographic texture within each weld is compatible with improved ultrasonic transmission. The application of the results to the inspection of a specific weld in type 316 weld metal is described

  19. Inspection of PFR steam generators

    International Nuclear Information System (INIS)

    The inspection of PFR evaporator tubing, superheater and reheater tubing, and tube plate examinations, are described. Ferritic steel U tubes in the evaporator have been examined by an eddy current system operating at 400 kHz using flexible rotating probes. Surface defects as shallow as 0.1 mm can be detected and sized in the range 0.1 to 0.5 mm deep. An ultrasonic method is under development for wall thickness. Special test coil probes have been developed for examination of the type 316 stainless steel superheater and reheater tubing. Crack-life defects in the bore are detectable at approximately 10% wall thickness and 20% on the outside diameter. Tube plate examinations from the tube holes, have been conducted using eddy current probes which identify surface breaking cracks in the holes. For detecting curtain cracks between tube plate holes, ultrasonic compression wave probes have been used. (U.K.)

  20. Working session 2: Tubing inspection

    Energy Technology Data Exchange (ETDEWEB)

    Guerra, J. [Tecnatom, S.A. San Sebastian de los Reyes, Madrid (Spain); Tapping, R.L. [AECL, Chalk River, Ontario (Canada)

    1997-02-01

    This session was attended by delegates from 10 countries, and four papers were presented. A wide range of issues was tabled for discussion. Realizing that there was limited time available for more detailed discussion, three topics were chosen for the more detailed discussion: circumferential cracking, performance demonstration (to focus on POD and sizing), and limits of methods. Two other subsessions were organized: one dealt with some challenges related to the robustness of current inspection methods, especially with respect to leaving cracked tubes in service, and the other with developing a chart of current NDE technology with recommendations for future development. These three areas are summarized in turn, along with conclusions and/or recommendations. During the discussions there were four presentations. There were two (Canada, Japan) on eddy current probe developments, both of which addressed multiarray probes that would detect a range of flaws, one (Spain) on circumferential crack detection, and one (JRC, Petten) on the recent PISC III results.