WorldWideScience

Sample records for climatology project d2

  1. Galactic cosmic ray and El Nino Southern Oscillation trends in International Satellite Cloud Climatology Project D2 low-cloud properties

    DEFF Research Database (Denmark)

    Marsh, N.; Svensmark, Henrik

    2003-01-01

    [1] The recently reported correlation between clouds and galactic cosmic rays (GCR) implies the existence of a previously unknown process linking solar variability and climate. An analysis of the interannual variability of International Satellite Cloud Climatology Project D2 (ISCCP-D2) low....... Instead, it is argued that a mechanism involving solar variability via GCR ionization of the atmosphere is consistent with these results. However, the results are marginal when including the recently extended ISCCP-D2 data covering the period until September 2001. This, we believe, is related to problems...

  2. International Satellite Cloud Climatology Project (ISCCP)

    Data.gov (United States)

    National Aeronautics and Space Administration — International Satellite Cloud Climatology Project (ISCCP) focuses on the distribution and variation of cloud radiative properties to improve the understanding of the...

  3. Global Precipitation Climatology Project (GPCP) - Pentad, Version 2.2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Global Precipitation Climatology Project (GPCP) comprises a total of 27 products. The Version 2.2 Pentad product covers the period January 1979 to the present,...

  4. Global Precipitation Climatology Project (GPCP) - Monthly, Version 2.2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Global Precipitation Climatology Project (GPCP) comprises a total of 27 products with the two primary products being the monthly satellite-gauge and associated...

  5. Global Precipitation Climatology Project (GPCP) - Daily, Version 1.2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Global Precipitation Climatology Project (GPCP) comprises a total of 27 products. The Version 1.2 Daily product covers the period October 1998 to the present,...

  6. The Global Precipitation Climatology Project (GPCP) Combined Precipitation Dataset

    Science.gov (United States)

    Huffman, George J.; Adler, Robert F.; Arkin, Philip; Chang, Alfred; Ferraro, Ralph; Gruber, Arnold; Janowiak, John; McNab, Alan; Rudolf, Bruno; Schneider, Udo

    1997-01-01

    The Global Precipitation Climatology Project (GPCP) has released the GPCP Version 1 Combined Precipitation Data Set, a global, monthly precipitation dataset covering the period July 1987 through December 1995. The primary product in the dataset is a merged analysis incorporating precipitation estimates from low-orbit-satellite microwave data, geosynchronous-orbit -satellite infrared data, and rain gauge observations. The dataset also contains the individual input fields, a combination of the microwave and infrared satellite estimates, and error estimates for each field. The data are provided on 2.5 deg x 2.5 deg latitude-longitude global grids. Preliminary analyses show general agreement with prior studies of global precipitation and extends prior studies of El Nino-Southern Oscillation precipitation patterns. At the regional scale there are systematic differences with standard climatologies.

  7. Recent trends of the tropical hydrological cycle inferred from Global Precipitation Climatology Project and International Satellite Cloud Climatology Project data

    Science.gov (United States)

    Zhou, Y. P.; Xu, Kuan-Man; Sud, Y. C.; Betts, A. K.

    2011-05-01

    Scores of modeling studies have shown that increasing greenhouse gases in the atmosphere impact the global hydrologic cycle; however, disagreements on regional scales are large, and thus the simulated trends of such impacts, even for regions as large as the tropics, remain uncertain. The present investigation attempts to examine such trends in the observations using satellite data products comprising Global Precipitation Climatology Project precipitation and International Satellite Cloud Climatology Project cloud and radiation. Specifically, evolving trends of the tropical hydrological cycle over the last 20-30 years were identified and analyzed. The results show (1) intensification of tropical precipitation in the rising regions of the Walker and Hadley circulations and weakening over the sinking regions of the associated overturning circulation; (2) poleward shift of the subtropical dry zones (up to 2° decade-1 in June-July-August (JJA) in the Northern Hemisphere and 0.3-0.7° decade-1 in June-July-August and September-October-November in the Southern Hemisphere) consistent with an overall broadening of the Hadley circulation; and (3) significant poleward migration (0.9-1.7° decade-1) of cloud boundaries of Hadley cell and plausible narrowing of the high cloudiness in the Intertropical Convergence Zone region in some seasons. These results support findings of some of the previous studies that showed strengthening of the tropical hydrological cycle and expansion of the Hadley cell that are potentially related to the recent global warming trends.

  8. KLIMHIST: A Project on Historical Climatology in Portugal

    Science.gov (United States)

    Fragoso, Marcelo; João Alcoforado, Maria; Santos, João A.

    2013-04-01

    Climatic variability from the beginning of regular meteorological observations is now acknowledged. However, climate change prior to 1900 is far from being well known in Portugal, except for the 1675-1800 period in Southern Portugal. An interdisciplinary team is working in the frame of the KLIMHIST PROJECT ("Reconstruction and model simulations of past climate in Portugal using documentary and early instrumental sources, 17th-19th century)", since May 2012. The main objectives of the project are: (i) to contribute to the creation of a long-term history of climate in Portugal by producing databases of documentary evidence and of instrumental data since 1645, a period of natural climate variability that includes the Maunder Minimum and the Dalton Minimum; (ii) to search systematically for the first simultaneous documentary and instrumental data in order to calibrate the series; (iii) to analyse simulated multi-decadal trends over Portugal generated by climate models; (iv) to compare results with those obtained from dendroclimatology and from geothermal studies regarding Portugal and (v) to study extreme events of the past, their impacts and the vulnerability of societies to weather during the last 350 years, and compare them with current analogues. With these tasks, we expect to help completing the spatial coverage of past European climate, as the data gap over SW Europe is often mentioned. As the team members come from four different Universities in Portugal (Évora, Lisbon, Oporto and UTAD), we expect to obtain a good spatial representation of documentary evidence. Teams are now progressing in data search activities in archives. An Access database frame was constructed. Some 18th century extreme events have been and are being studied (Barbara storm, Dec.1739, among others). The first workshop took place in Lisbon (October 2012): Prof Brázdil and Dr. Domínguez-Castro (two of our consultants) were keynote speakers. Key-words: Climate reconstruction, Documentary

  9. Recent trends of the tropical hydrological cycle inferred from Global Precipitation Climatology Project and International Satellite Cloud Climatology Project datasets

    Science.gov (United States)

    Sud, Y. C.; Zhou, Y.; Xu, K.; Betts, A. K.

    2012-12-01

    Among the greenhouse gases induced climate change projections, tropical hydrological cycle changes can be expected to cause significant deficit or excess of precipitation in many regions, and that in turn would impact all life on earth. We have examined decadal trends of the tropical hydrological cycle in the GPCP precipitation and ISCCP cloud and radiation datasets to determine if such trends can provide an observation-based benchmark for model predictions of the ongoing climate change. The observations data show (1) intensifications of tropical precipitation in the rising regions of the Walker and Hadley circulations and weakening over the sinking regions - showcasing the "wet-getting-wetter, dry-getting-dryer" phenomena; (2) a discernible poleward shift of the subtropical dry zones (up to 2° decade-1 in June-July-August (JJA) in the Northern Hemisphere and 0.3-0.7° decade-1 in JJA and September-October-November (SON) in the Southern Hemisphere consistent with an overall broadening of the Hadley circulation; and (3) some poleward migration of cloud boundaries within Hadley cell and plausible narrowing of the high cloudiness in the Intertropical Convergence Zone (ITCZ) region in some seasons. These trends indicate a strengthening of the tropical hydrological cycle with intensification of dry and wet extremes.

  10. The Version 2 Global Precipitation Climatology Project (GPCP) Monthly Precipitation Analysis (1979-Present)

    Science.gov (United States)

    Adler, Robert F.; Huffman, George J.; Chang, Alfred; Ferraro, Ralph; Xie, Ping-Ping; Janowiak, John; Rudolf, Bruno; Schneider, Udo; Curtis, Scott; Bolvin, David

    2003-01-01

    The Global Precipitation Climatology Project (GPCP) Version 2 Monthly Precipitation Analysis is described. This globally complete, monthly analysis of surface precipitation at 2.5 degrees x 2.5 degrees latitude-longitude resolution is available from January 1979 to the present. It is a merged analysis that incorporates precipitation estimates from low-orbit-satellite microwave data, geosynchronous-orbit-satellite infrared data, and rain gauge observations. The merging approach utilizes the higher accuracy of the low-orbit microwave observations to calibrate, or adjust, the more frequent geosynchronous infrared observations. The data set is extended back into the premicrowave era (before 1987) by using infrared-only observations calibrated to the microwave-based analysis of the later years. The combined satellite-based product is adjusted by the raingauge analysis. This monthly analysis is the foundation for the GPCP suite of products including those at finer temporal resolution, satellite estimate, and error estimates for each field. The 23-year GPCP climatology is characterized, along with time and space variations of precipitation.

  11. Normalization and calibration of geostationary satellite radiances for the International Satellite Cloud Climatology Project

    Science.gov (United States)

    Desormeaux, Yves; Rossow, William B.; Brest, Christopher L.; Campbell, G. G.

    1993-01-01

    Procedures are described for normalizing the radiometric calibration of image radiances obtained from geostationary weather satellites that contributed data to the International Satellite Cloud Climatology Project. The key step is comparison of coincident and collocated measurements made by each satellite and the concurrent AVHRR on the 'afternoon' NOAA polar-orbiting weather satellite at the same viewing geometry. The results of this comparison allow transfer of the AVHRR absolute calibration, which has been established over the whole series, to the radiometers on the geostationary satellites. Results are given for Meteosat-2, 3, and 4, for GOES-5, 6, and 7, for GMS-2, 3, and 4 and for Insat-1B. The relative stability of the calibrations of these radiance data is estimated to be within +/- 3 percent; the uncertainty of the absolute calibrations is estimated to be less than 10 percent. The remaining uncertainties are at least two times smaller than for the original radiance data.

  12. 3D-2D registration for surgical guidance: effect of projection view angles on registration accuracy

    Science.gov (United States)

    Uneri, A.; Otake, Y.; Wang, A. S.; Kleinszig, G.; Vogt, S.; Khanna, A. J.; Siewerdsen, J. H.

    2014-01-01

    An algorithm for intensity-based 3D-2D registration of CT and x-ray projections is evaluated, specifically using single- or dual-projection views to provide 3D localization. The registration framework employs the gradient information similarity metric and covariance matrix adaptation evolution strategy to solve for the patient pose in six degrees of freedom. Registration performance was evaluated in an anthropomorphic phantom and cadaver, using C-arm projection views acquired at angular separation, Δθ, ranging from ˜0°-180° at variable C-arm magnification. Registration accuracy was assessed in terms of 2D projection distance error and 3D target registration error (TRE) and compared to that of an electromagnetic (EM) tracker. The results indicate that angular separation as small as Δθ ˜10°-20° achieved TRE registration of preoperative CT and planning data to intraoperative fluoroscopy, providing 3D localization free from conventional limitations associated with external fiducial markers, stereotactic frames, trackers and manual registration.

  13. Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections.

    Science.gov (United States)

    Kupchik, Yonatan M; Brown, Robyn M; Heinsbroek, Jasper A; Lobo, Mary Kay; Schwartz, Danielle J; Kalivas, Peter W

    2015-09-01

    It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

  14. Projected double use of a rectangular roof-bolted roadway at a depth of 1200 m in seam D2/C; Geplante Doppelnutzung einer Rechteckankerstrecke in 1200 m Teufe im Floez D2/C

    Energy Technology Data Exchange (ETDEWEB)

    Breinig, F. [Bergbau AG Lippe, Gelsenkirchen (Germany); Opolony, K. [DSK-Werksdirektion zentrale Technik, Herne (Germany)

    2004-08-01

    The contribution outlines the projecting of seam D2/C at Lippe mine, which will be characterized by double use of the roof-bolted roadway. The experience with dimensioning based on numeric and physical investigations is presented, and the performance so far is described and analyzed. (orig.) [German] Der Beitrag schildert die Planung des Floezes D2/C auf dem Bergwerk Lippe. Beginnend mit dem Projekt der ersten Rechteckankerstrecke in der BH 328 und dem Teilprojekt 'Offenhalten nach Strebdurchgang' bis zur Entwicklung eines Ausbauschemas fuer die Doppelnutzung der Kohlenabfuhrstrecke in der BH 330 des Floezes D2/C. Die Entwicklungen der Ausbau- und Verschalungseinheit fuer die neue Dammtechnik wird eroertert und die Erfahrung mit den Dimensionierungsmethoden, basierend auf numerischen und physikalischen Untersuchungen, dargestellt. Abschliessend werden die Betriebserfahrungen der ersten Nutzung dargelegt und analysiert. (orig.)

  15. Dual-projection 3D-2D registration for surgical guidance: preclinical evaluation of performance and minimum angular separation

    Science.gov (United States)

    Uneri, A.; Otake, Y.; Wang, A. S.; Kleinszig, G.; Vogt, S.; Gallia, G. L.; Rigamonti, D.; Wolinsky, J.-P.; Gokaslan, Ziya L.; Khanna, A. J.; Siewerdsen, J. H.

    2014-03-01

    An algorithm for 3D-2D registration of CT and x-ray projections has been developed using dual projection views to provide 3D localization with accuracy exceeding that of conventional tracking systems. The registration framework employs a normalized gradient information (NGI) similarity metric and covariance matrix adaptation evolution strategy (CMAES) to solve for the patient pose in 6 degrees of freedom. Registration performance was evaluated in anthropomorphic head and chest phantoms, as well as a human torso cadaver, using C-arm projection views acquired at angular separations (Δ𝜃) ranging 0-178°. Registration accuracy was assessed in terms target registration error (TRE) and compared to that of an electromagnetic tracker. Studies evaluated the influence of C-arm magnification, x-ray dose, and preoperative CT slice thickness on registration accuracy and the minimum angular separation required to achieve TRE ~2 mm. The results indicate that Δ𝜃 as small as 10-20° is adequate to achieve TRE registration of preoperative CT and planning data to intraoperative fluoroscopy, providing 3D localization free from conventional limitations associated with external fiducial markers, stereotactic frames, trackers, and manual registration. The studies support potential application to percutaneous spine procedures and intracranial neurosurgery.

  16. Projected changes in temperature and precipitation climatology of Central Asia CORDEX Region 8 by using RegCM4.3.5

    Science.gov (United States)

    Ozturk, Tugba; Turp, M. Tufan; Türkeş, Murat; Kurnaz, M. Levent

    2017-01-01

    This work investigated projected future changes in seasonal mean air temperature (°C) and precipitation (mm/day) climatology for the three periods of 2011-2040, 2041-2070, and 2071-2100, with respect to the control period of 1971-2000 for the Central Asia domain via regional climate model simulations. In order to investigate the projected changes in near future climate conditions, the Regional Climate Model, RegCM4.3.5 of the International Centre for Theoretical Physics (ICTP) was driven by two different CMIP5 global climate models. The HadGEM2-ES global climate model of the Met Office Hadley Centre and the MPI-ESM-MR global climate model of the Max Planck Institute for Meteorology were downscaled to 50 km for the Coordinated Regional Climate Downscaling Experiment (CORDEX) Region 8. We investigated the seasonal time-scale performance of RegCM4.3.5 in reproducing observed climatology over the domain of the Central Asia by using two different global climate model outputs. For the future climatology of the domain, the regional model projects relatively high warming in the warm season with a decrease in precipitation in almost all parts of the domain. A warming trend is notable, especially for the northern part of the domain during the cold season. The results of our study show that surface air temperatures in the region will increase between 3 °C and about 7 °C on average, according to the emission scenarios for the period of 2071-2100 with respect to past period of 1971-2000. Therefore, the projected warming and decrease in precipitation might adversely affect the ecological and socio-economic systems of this region, which is already a mostly arid and semi-arid environment.

  17. Validation of Long-Term Global Aerosol Climatology Project Optical Thickness Retrievals Using AERONET and MODIS Data

    Directory of Open Access Journals (Sweden)

    Igor V. Geogdzhayev

    2015-09-01

    Full Text Available A comprehensive set of monthly mean aerosol optical thickness (AOT data from coastal and island AErosol RObotic NETwork (AERONET stations is used to evaluate Global Aerosol Climatology Project (GACP retrievals for the period 1995–2009 during which contemporaneous GACP and AERONET data were available. To put the GACP performance in broader perspective, we also compare AERONET and MODerate resolution Imaging Spectroradiometer (MODIS Aqua level-2 data for 2003–2009 using the same methodology. We find that a large mismatch in geographic coverage exists between the satellite and ground-based datasets, with very limited AERONET coverage of open-ocean areas. This is especially true of GACP because of the smaller number of AERONET stations at the early stages of the network development. Monthly mean AOTs from the two over-the-ocean satellite datasets are well-correlated with the ground-based values, the correlation coefficients being 0.81–0.85 for GACP and 0.74–0.79 for MODIS. Regression analyses demonstrate that the GACP mean AOTs are approximately 17%–27% lower than the AERONET values on average, while the MODIS mean AOTs are 5%–25% higher. The regression coefficients are highly dependent on the weighting assumptions (e.g., on the measure of aerosol variability as well as on the set of AERONET stations used for comparison. Comparison of over-the-land and over-the-ocean MODIS monthly mean AOTs in the vicinity of coastal AERONET stations reveals a significant bias. This may indicate that aerosol amounts in coastal locations can differ significantly from those in adjacent open-ocean areas. Furthermore, the color of coastal waters and peculiarities of coastline meteorological conditions may introduce biases in the GACP AOT retrievals. We conclude that the GACP and MODIS over-the-ocean retrieval algorithms show similar ranges of discrepancy when compared to available coastal and island AERONET stations. The factors mentioned above may limit the

  18. Galactic cosmic ray and El Nino Southern Oscillation trends in International Satellite Cloud Climatology Project D2 low-cloud properties

    DEFF Research Database (Denmark)

    Marsh, N.; Svensmark, Henrik

    2003-01-01

    -cloud properties over the period July 1983 to August 1994 suggests that low clouds are statistically related to two processes, (1) GCR and (2) El Nino-Southern Oscillation (ENSO), with GCR explaining a greater percentage of the total variance. Areas where satellites have an unobstructed view of low cloud possess...

  19. Projected changes in tropical cyclone climatology and landfall in the Southwest Indian Ocean region under enhanced anthropogenic forcing

    CSIR Research Space (South Africa)

    Malherbe, J

    2012-12-01

    Full Text Available scenario. Projections for the latter part of the 21st century indicate a decrease in the occurrence of tropical cyclones over the Southwest Indian Ocean adjacent to southern Africa, as well as a northward shift in the preferred landfall position...

  20. Historical Climatology Series

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Historical Climatology Series (HCS) is a set of climate-related publications published by NOAA's National Climatic Data Center beginning in 1978. HCS is...

  1. Preliminary Monthly Climatological Summaries

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Preliminary Local Climatological Data, recorded since 1970 on Weather Burean Form 1030 and then National Weather Service Form F-6. The preliminary climate data pages...

  2. Global Synoptic Climatology Network

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Global Synoptic Climatology Network is a digital data set archived at the National Climatic Data Center (NCDC). This record combines the various types of data that...

  3. Climatological Data National Summary

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The CDNS was published from 1950 - 1980. Monthly and annual editions contain summarized climatological information from the following publications: Local...

  4. Climatological Services Memorandums

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Climatological Services Memorandums were a series of memoranda issued by the Weather Bureau for the purpose of keeping all stations informed on the status and...

  5. Reference Climatological Stations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Reference Climatological Stations (RCS) network represents the first effort by NOAA to create and maintain a nationwide network of stations located only in areas...

  6. Pliocene Model Intercomparison Project Experiment 1: implementation strategy and mid-Pliocene global climatology using GENESIS v3.0 GCM

    Science.gov (United States)

    Koenig, S. J.; Deconto, R. M.; Pollard, D.

    2012-01-01

    The mid-Pliocene Warm Period (3.29 to 2.97 Ma BP) has been identified as an analogue for the future, with the potential to help understand climate processes in a warmer than modern world. Sets of climate proxies, combined to provide boundary conditions for Global Climate Model (GCM) simulations of the mid-Pliocene, form the basis for the international, data-driven Pliocene Model Intercomparison Project (PlioMIP). Here, we outline the strategy for implementing pre-industrial (modern) and mid-Pliocene forcings and boundary conditions into the GENESIS version 3 GCM, as part of PlioMIP. We describe the prescription of greenhouse gas concentrations and orbital parameters and the implementation of geographic boundary conditions such as land-ice-sea distribution, topography, sea surface temperatures, sea ice extent, vegetation, soils, and ice sheets. We further describe model-specific details including spin-up and integration times. In addition, the global climatology of the mid-Pliocene as simulated by the GENESIS v3 GCM is analyzed and compared to the pre-industrial control simulation. The simulated climate of the mid-Pliocene warm interval is found to differ considerably from pre-industrial. We identify model sensitivity to imposed forcings, and internal feedbacks that collectively affect both local and far-field responses. Our analysis points out the need to assess both the direct impacts of external forcings and the combined effects of indirect, internal feedbacks. This paper provides the basis for assessing model biases within the PlioMIP framework, and will be useful for comparisons with other studies of mid-Pliocene climates.

  7. Projected dual-purpose use of a rectangular bolted section at a depth of 1200 m in the D2/C seam; Geplante Doppelnutzung einer Rechteckankerstrecke in 1200m Teufe im Floez D2/C

    Energy Technology Data Exchange (ETDEWEB)

    Breinig, F.; Opolony, K. [Deutsche Steinkohle AG (Germany)

    2004-07-01

    The report gives an insight view to the planning of excavation and support design in seam D2/C at the Lippe mine. Starting with the first rectangular rockbolted tailgate from panel 328 and the subproject rectangular rockbolted roadways for advanced mining'' up to the design of rockbolting pattern for re-use of the maingate of panel 330 in the D2/C seam. The engineering and development of a combined support and casing-unit for recent roadside packages are descibed as well as experience in new dimensioning based upon numerical and physical modelling. Finally the operational experience of the first use are displayed and analysed.

  8. The NEWS Water Cycle Climatology

    Science.gov (United States)

    Rodell, Matthew; Beaudoing, Hiroko Kato; L'Ecuyer, Tristan; William, Olson

    2012-01-01

    NASA's Energy and Water Cycle Study (NEWS) program fosters collaborative research towards improved quantification and prediction of water and energy cycle consequences of climate change. In order to measure change, it is first necessary to describe current conditions. The goal of the first phase of the NEWS Water and Energy Cycle Climatology project was to develop "state of the global water cycle" and "state of the global energy cycle" assessments based on data from modern ground and space based observing systems and data integrating models. The project was a multi-institutional collaboration with more than 20 active contributors. This presentation will describe the results of the water cycle component of the first phase of the project, which include seasonal (monthly) climatologies of water fluxes over land, ocean, and atmosphere at continental and ocean basin scales. The requirement of closure of the water budget (i.e., mass conservation) at various scales was exploited to constrain the flux estimates via an optimization approach that will also be described. Further, error assessments were included with the input datasets, and we examine these in relation to inferred uncertainty in the optimized flux estimates in order to gauge our current ability to close the water budget within an expected uncertainty range.

  9. Projects in Computer Aided Climatology.

    Science.gov (United States)

    1981-07-01

    Always blank 17 Cbservation herder column (blank or 9) if ŝ" the scope is clear Always blank 19 Azimuth angle 1 header (blank or 9) if ŝ" there are no...optional. SUBSECTION I-A THE EQUATIONS OF TRANSFORMATION The mapping procedure used was originally proposed by the Swiss mathematician, Johann Heinrich

  10. Local Climatological Data ACSII Format

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Comma-delimited text files used to create the Local Climatological Data PDF files found in the Local Climatological Data library. Period of record begins in 1998,...

  11. 3D-2D Medical Image Registration Based on Near Projective Invariance%基于投影近似不变性的3D-2D医学图像配准

    Institute of Scientific and Technical Information of China (English)

    秦中元; 牟轩沁

    2006-01-01

    研究了同一病人的MRA和DSA图像之间的3D-2D配准问题,提出了一种基于投影近似不变性的配准算法,即在同一视角下,同一病人的三维MRA血管骨架的投影与二维DSA的骨架保持一致.通过定义二者之间的代价函数,并利用牛顿迭代法可得到视角参数的最优解.针对临床采集的MRA和DSA数据进行了实验,取得了较为满意的结果.

  12. L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia

    Science.gov (United States)

    Suarez, Luz M; Solis, Oscar; Aguado, Carolina; Lujan, Rafael; Moratalla, Rosario

    2016-01-01

    Dopamine depletion in Parkinson's disease (PD) produces dendritic spine loss in striatal medium spiny neurons (MSNs) and increases their excitability. However, the synaptic changes that occur in MSNs in PD, in particular those induced by chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment, are still poorly understood. We exposed BAC-transgenic D1-tomato and D2-eGFP mice to PD and dyskinesia model paradigms, enabling cell type-specific assessment of changes in synaptic physiology and morphology. The distinct fluorescence markers allowed us to identify D1 and D2 MSNs for analysis using intracellular sharp electrode recordings, electron microscopy, and 3D reconstructions with single-cell Lucifer Yellow injections. Dopamine depletion induced spine pruning in both types of MSNs, affecting mushroom and thin spines equally. Dopamine depletion also increased firing rate in both D1- and D2-MSNs, but reduced evoked-EPSP amplitude selectively in D2-MSNs. L-DOPA treatment that produced dyskinesia differentially affected synaptic properties in D1- and D2-MSNs. In D1-MSNs, spine density remained reduced but the remaining spines were enlarged, with bigger heads and larger postsynaptic densities. These morphological changes were accompanied by facilitation of action potential firing triggered by synaptic inputs. In contrast, although L-DOPA restored the number of spines in D2-MSNs, it resulted in shortened postsynaptic densities. These changes in D2-MSNs correlated with a decrease in synaptic transmission. Our findings indicate that L-DOPA-induced dyskinesia is associated with abnormal spine morphology, modified synaptic transmission, and altered EPSP-spike coupling, with distinct effects in D1- and D2-MSNs. PMID:27613437

  13. L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia.

    Science.gov (United States)

    Suarez, Luz M; Solis, Oscar; Aguado, Carolina; Lujan, Rafael; Moratalla, Rosario

    2016-10-17

    Dopamine depletion in Parkinson's disease (PD) produces dendritic spine loss in striatal medium spiny neurons (MSNs) and increases their excitability. However, the synaptic changes that occur in MSNs in PD, in particular those induced by chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment, are still poorly understood. We exposed BAC-transgenic D1-tomato and D2-eGFP mice to PD and dyskinesia model paradigms, enabling cell type-specific assessment of changes in synaptic physiology and morphology. The distinct fluorescence markers allowed us to identify D1 and D2 MSNs for analysis using intracellular sharp electrode recordings, electron microscopy, and 3D reconstructions with single-cell Lucifer Yellow injections. Dopamine depletion induced spine pruning in both types of MSNs, affecting mushroom and thin spines equally. Dopamine depletion also increased firing rate in both D1- and D2-MSNs, but reduced evoked-EPSP amplitude selectively in D2-MSNs. L-DOPA treatment that produced dyskinesia differentially affected synaptic properties in D1- and D2-MSNs. In D1-MSNs, spine density remained reduced but the remaining spines were enlarged, with bigger heads and larger postsynaptic densities. These morphological changes were accompanied by facilitation of action potential firing triggered by synaptic inputs. In contrast, although L-DOPA restored the number of spines in D2-MSNs, it resulted in shortened postsynaptic densities. These changes in D2-MSNs correlated with a decrease in synaptic transmission. Our findings indicate that L-DOPA-induced dyskinesia is associated with abnormal spine morphology, modified synaptic transmission, and altered EPSP-spike coupling, with distinct effects in D1- and D2-MSNs. © The Author 2016. Published by Oxford University Press.

  14. Estonian total ozone climatology

    Directory of Open Access Journals (Sweden)

    K. Eerme

    Full Text Available The climatological characteristics of total ozone over Estonia based on the Total Ozone Mapping Spectrometer (TOMS data are discussed. The mean annual cycle during 1979–2000 for the site at 58.3° N and 26.5° E is compiled. The available ground-level data interpolated before TOMS, have been used for trend detection. During the last two decades, the quasi-biennial oscillation (QBO corrected systematic decrease of total ozone from February–April was 3 ± 2.6% per decade. Before 1980, a spring decrease was not detectable. No decreasing trend was found in either the late autumn ozone minimum or in the summer total ozone. The QBO related signal in the spring total ozone has an amplitude of ± 20 DU and phase lag of 20 months. Between 1987–1992, the lagged covariance between the Singapore wind and the studied total ozone was weak. The spring (April–May and summer (June–August total ozone have the best correlation (coefficient 0.7 in the yearly cycle. The correlation between the May and August total ozone is higher than the one between the other summer months. Seasonal power spectra of the total ozone variance show preferred periods with an over 95% significance level. Since 1986, during the winter/spring, the contribution period of 32 days prevails instead of the earlier dominating 26 days. The spectral densities of the periods from 4 days to 2 weeks exhibit high interannual variability.

    Key words. Atmospheric composition and structure (middle atmosphere – composition and chemistry; volcanic effects – Meteorology and atmospheric dynamics (climatology

  15. What does it mean to sustain a research infrastructure? : Experiences and recommendations from the experience of the CENDARI Project. (D2.4 Sustainability Plan)

    NARCIS (Netherlands)

    Edmond, Jennifer; Morselli, Francesca

    2016-01-01

    The CENDARI project committed in its original description of work to the production of a Business Plan (Deliverable 2.4), outlining a method statement for ensuring that the outputs of the CENDARI project would be available to future users. The project team decided to rename this deliverable the CEND

  16. D2-tree

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Sioutas, Spyros; Pantazos, Kostas;

    2015-01-01

    We present a new overlay, called the Deterministic Decentralized tree (D2-tree). The D2-tree compares favorably to other overlays for the following reasons: (a) it provides matching and better complexities, which are deterministic for the supported operations; (b) the management of nodes (peers......-balancing scheme of elements into nodes is deterministic and general enough to be applied to other hierarchical tree-based overlays. This load-balancing mechanism is based on an innovative lazy weight-balancing mechanism, which is interesting in its own right....

  17. Advances in tourism climatology

    Energy Technology Data Exchange (ETDEWEB)

    Matzarakis, A.; Freitas, C.R. de; Scott, D. (eds.)

    2004-11-01

    This publication grew out of the Second International Workshop of the International Society of Biometeorology, Commission on Climate Tourism and Recreation (ISB-CCTR) that took place at the Orthodox Academy of Crete in Kolimbari, Greece, 8-11 June 2004. The aim of the meeting was to (a) bring together a selection of researchers and tourism experts to review the current state of knowledge of tourism and recreation climatology and (b) explore possibilities for future research and the role of the ISB-CCTR in this. A total of 40 delegates attended the June 2004 ISB-CCTR Workshop. Their fields of expertise included biometeorology, bioclimatology, thermal comfort and heat balance modelling, tourism marketing and planning, urban and landscape planning, architecture, climate change, emission reduction and climate change impact assessment. Participants came from universities and research institutions in Australia, Austria, Canada, Croatia, France, Germany, Greece, Hungary, Italy, the Netherlands, New Zealand, Portugal, Slovenia, United Kingdom and United States of America. Business conducted at the Workshop was divided between five sessions: assessment of climatic resources; climate change; health; weather, sports and risk forecasts; and behaviour and perception. However, the content of this publication is organised so that it reflects the new perspectives and methods that have evolved since the ISB-CCTR was established. (orig.)

  18. Biomes computed from simulated climatologies

    National Research Council Canada - National Science Library

    Claussen, M; Esch, M

    1992-01-01

    The biome model of Prentice is used to predict global patterns of potential natural plant formations, or biomes, from climatologies simulated by ECHAM, a model used for climate simulations at the Max...

  19. Local Climatological Data (LCD) Publication

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Local Climatological Data (LCD) contains summaries from major airport weather stations that include a daily account of temperature extremes, degree days,...

  20. Climatology of damage-causing hailstorms over Germany

    Science.gov (United States)

    Kunz, M.; Puskeiler, M.; Schmidberger, M.

    2012-04-01

    In several regions of Central Europe, such as southern Germany, Austria, Switzerland, and northern Italy, hailstorms often cause substantial damage to buildings, crops, or automobiles on the order of several million EUR. In the federal state of Baden-Württemberg, for example, most of the insured damage to buildings is caused by large hailstones. Due to both their local-scale extent and insufficient direct monitoring systems, hail swaths are not captured accurately and uniquely by a single observation system. Remote-sensing systems such as radars are able to detect convection signals in a basic way, but they lack the ability to discern a clear relation between measured intensity and hail on the ground. These shortcomings hamper statistical analysis on the hail probability and intensity. Hail modelling thus is a big challenge for the insurance industry. Within the project HARIS-CC (Hail Risk and Climate Change), different meteorological observations are combined (3D / 2D radar, lightning, satellite and radiosounding data) to obtain a comprehensive picture of the hail climatology over Germany. The various approaches were tested and calibrated with loss data from different insurance companies between 2005 and 2011. Best results are obtained by considering the vertical distance between the 0°C level of the atmosphere and the echo top height estimated from 3D reflectivity data from the radar network of German Weather Service (DWD). Additionally, frequency, intensity, width, and length of hail swaths are determined by applying a cell tracking algorithm to the 3D radar data (TRACE3D; Handwerker, 2002). The hailstorm tracks identified are merged with loss data using a geographical information system (GIS) to verify damage-causing hail on the ground. Evaluating the hailstorm climatology revealed that hail probability exhibits high spatial variability even over short distances. An important issue is the spatial pattern of hail occurrence that is considered to be due to

  1. U.S. Local Climatological Data (LCD)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Local Climatological Data (LCD) are summaries of climatological conditions from airport and other prominent weather stations managed by NWS, FAA, and DOD. The...

  2. The HOAPS-II climatology - Release II of the satellite-derived freshwater flux climatology

    Science.gov (United States)

    Fennig, K.; Klepp, C.; Bakan, S.; Schulz, J.; Graßl, H.

    2003-04-01

    HOAPS-II (Hamburg Ocean Atmosphere Parameters and Fluxes from Satellite Data) is the improved global climatology of sea surface parameters and surface energy and freshwater fluxes derived from satellite radiances for the time period July 1987 until the recent dates. Data from polar orbiting radiometers, all available Special Sensor Microwave/Imager (SSM/I) radiometers and the Advanced Very High Resolution Radiometer (AVHRR), have been used to get global fields of surface meteorological and oceanographic parameters but also latent heat flux, evaporation, precipitation and net freshwater flux as well as the wind speed, water vapor- and total water content over ice free ocean areas for various averaging periods and grid sizes including scan orientated data in the NetCDF data format. All retrieval methods have been validated with in situ data on a global scale with a focus on precipitation validation. The new release of the data base is freely available to the community. Additionally, applications of the HOAPS-II data base will demonstrate its ability to detect ground validated High Impact Weather over global oceans that the Global Precipitation Climatology Project (GPCP) climatology and the ECMWF model is frequently missing. Nowcasting of model-unpredicted storms is a high potential application of this new data base.

  3. The Climatology of Australian Aerosol

    Science.gov (United States)

    Mitchell, Ross M.; Forgan, Bruce W.; Campbell, Susan K.

    2017-04-01

    Airborne particles or aerosols have long been recognised for their major contribution to uncertainty in climate change. In addition, aerosol amounts must be known for accurate atmospheric correction of remotely sensed images, and are required to accurately gauge the available solar resource. However, despite great advances in surface networks and satellite retrievals over recent years, long-term continental-scale aerosol data sets are lacking. Here we present an aerosol assessment over Australia based on combined sun photometer measurements from the Bureau of Meteorology Radiation Network and CSIRO/AeroSpan. The measurements are continental in coverage, comprising 22 stations, and generally decadal in timescale, totalling 207 station-years. Monthly climatologies are given at all stations. Spectral decomposition shows that the time series can be represented as a weighted sum of sinusoids with periods of 12, 6 and 4 months, corresponding to the annual cycle and its second and third harmonics. Their relative amplitudes and phase relationships lead to sawtooth-like waveforms sharply rising to an austral spring peak, with a slower decline often including a secondary peak during the summer. The amplitude and phase of these periodic components show significant regional change across the continent. Fits based on this harmonic analysis are used to separate the periodic and episodic components of the aerosol time series. An exploratory classification of the aerosol types is undertaken based on (a) the relative periodic amplitudes of the Ångström exponent and aerosol optical depth, (b) the relative amplitudes of the 6- and 4-month harmonic components of the aerosol optical depth, and (c) the ratio of episodic to periodic variation in aerosol optical depth. It is shown that Australian aerosol can be broadly grouped into three classes: tropical, arid and temperate. Statistically significant decadal trends are found at 4 of the 22 stations. Despite the apparently small

  4. Comparative Climatology of Terrestrial Planets

    Science.gov (United States)

    Mackwell, Stephen J.; Simon-Miller, Amy A.; Harder, Jerald W.; Bullock, Mark A.

    stimulate further research on this critical subject. The study of climate involves much more than understanding atmospheric processes. This subtlety is particularly appreciated for Earth, where chemical cycles, geology, ocean influences, and biology are considered in most climate models. In Part IV, Surface and Interior, we look at the role that geochemical cycles, volcanism, and interior mantle processes play in the stability and evolution of terrestrial planetary climates. There is one vital commonality between the climates of all the planets of the solar system: Regardless of the different processes that dominate each of the climates of Earth, Mars, Venus, and Titan, they are all ultimately forced by radiation from the same star, albeit at variable distances. In Part V, Solar Influences, we discuss how the Sun's early evolution affected the climates of the terrestrial planets, and how it continues to control the temperatures and compositions of planetary atmospheres. This will be of particular interest as models of exoplanets, and the influences of much different stellar types and distances, are advanced by further observations. Comparisons of atmospheric and climate processes between the planets in our solar system has been a focus of numerous conferences over the past decade, including the Exoclimes conference series. In particular, this book project was closely tied to a conference on Comparative Climatology of Terrestrial Planets that was held in Boulder, Colorado, on June 25-28, 2012. This book benefited from the opportunity for the author teams to interact and obtain feedback from the broader community, but the chapters do not in general tie directly to presentations at the conference. The conference, which was organized by a diverse group of atmospheric and climate scientists led by Mark Bullock and Lori Glaze, sought to build connections between the various communities, focusing on synergies and complementary capabilities. Discussion panels at the end of most

  5. NORSEWInD satellite wind climatology

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Badger, Merete; Mouche, Alexis

    is to provide new offshore wind climatology map for the entire area of interest based on satellite remote sensing. This has been based on Synthetic Aperture Radar (SAR) from Envisat ASAR using 9000 scenes re-processed with ECMWF wind direction and CMOD-IFR. The number of overlapping samples range from 450....... QuikSCAT ocean wind vector observations have been analysed for the same four parameters and ASCAT for mean wind speed. All satellite data has been compared to in-situ observations available in the Norsewind project. SSM/I passive microwave wind speed data from 24 years observed around 6 times per day...... are used to estimate trends in offshore winds and interestingly a shift in the seasonal pattern is notice. All satellite-based wind products are valid at 10 m, thus it is desirable to lift winds to higher levels for wind energy products. A method has been suggested to lift winds from 10 m to hub...

  6. Analyzing global trends of different cloud types and their potential impacts on climate by using the ISCCP D2 dataset

    Institute of Scientific and Technical Information of China (English)

    DING Shouguo; SHI Guangyu; ZHAO Chunsheng

    2004-01-01

    The International Satellite Cloud Climatology Project (ISCCP) D2 dataset is used to study the global distribution of low, middle and high cloud amounts and their trends of 1983-2001. Evidences have shown that global warming has accelerated over the past 20 a and the 1990s was the warmest decade in the instrumental records since 1861. Trends of various clouds amounts over this period are analyzed by employing the linear regression method. The results show that global mean total cloud amounts, in general,have tended to reduce over the past 20 a. But there are slightly increasing by about 2% before 1987 and decreasing by about 4% since then. Cloudiness trends of both low and high clouds decrease while increase for the middle cloud.And there exist remarkable discrepancies in different regions.The preliminary analyses suggest that it is likely that the cloud change occurring over the past 20 a is a positive feedback to global warming.

  7. Los Alamos Climatology 2016 Update

    Energy Technology Data Exchange (ETDEWEB)

    Bruggeman, David Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-10

    The Los Alamos National Laboratory (LANL or the Laboratory) operates a meteorology monitoring network to support LANL emergency response, engineering designs, environmental compliance, environmental assessments, safety evaluations, weather forecasting, environmental monitoring, research programs, and environmental restoration. Weather data has been collected in Los Alamos since 1910. Bowen (1990) provided climate statistics (temperature and precipitation) for the 1961– 1990 averaging period, and included other analyses (e.g., wind and relative humidity) based on the available station locations and time periods. This report provides an update to the 1990 publication Los Alamos Climatology (Bowen 1990).

  8. Introduction to Global Urban Climatology

    Science.gov (United States)

    Varquez, A. C. G.; Kanda, M.; Kawano, N.; Darmanto, N. S.; Dong, Y.

    2016-12-01

    Urban heat island (UHI) is a widely investigated phenomenon in the field of urban climate characterized by the warming of urban areas relative to its surrounding rural environs. Being able to understand the mechanism behind the UHI formation of a city and distinguish its impact from that of global climate change is indispensable when identifying adaptation and mitigation strategies. However, the lack of UHI studies many cities especially for developing countries makes it difficult to generalize the mechanism for UHI formation. Thus, there is an impending demand for studies that focus on the simultaneous analyses of UHI and its trends throughout the world. Hence, we propose a subfield of urban climatology, called "global urban climatology" (GUC), which mainly focuses on the uniform understanding of urban climates across all cities, globally. By using globally applicable methodologies to quantify and compare urban heat islands of cities with diverse backgrounds, including their geography, climate, socio-demography, and other factors, a universal understanding of the mechanisms underlying the formation of the phenomenon can be established. The implementation of GUC involves the use of globally acquired historical observation networks, gridded meteorological parameters from climate models, global geographic information system datasets; the construction of a distributed urban parameter database; and the development of techniques necessary to model the urban climate. Research under GUC can be categorized into three approaches. The collaborative approach (1st) relies on the collection of data from micro-scale experiments conducted worldwide with the aid or development of professional social networking platforms; the analytical approach (2nd) relies on the use of global weather station datasets and their corresponding objectively analysed global outputs; and the numerical approach (3rd) relies on the global estimation of high-resolution urban-representative parameters as

  9. A Climatology of Central American Gyres

    Science.gov (United States)

    Papin, P. P.; Griffin, K. S.; Bosart, L. F.; Torn, R. D.

    2012-12-01

    Monsoon gyres, commonly found over the western Pacific Ocean, are characterized by broad low-level cyclonic circulations that occur at a variety of spatial scales ranging from 1500-3000 km. Low-level cyclonic gyre circulations, while less frequent and occupying a smaller scale, have also been observed over Central America during the tropical cyclone (TC) season. A noteworthy gyre observed during the 2010 PREDICT field project served as a "collector" of TC Matthew and a source for TC Nicole. During October 2011, devastating flooding occurred in Guatemala and El Salvador when TD 12-E, embedded in a gyre circulation, made landfall on the Pacific coast of Central America. These gyre occurrences, their apparent links to TC activity, and their association with high-impact weather motivates this presentation. A preliminary analysis of Central American gyres suggests that their spatial scales vary between 1000-2000 km. These gyres also tend to be co-located with reservoirs of deep moisture that are characterized by high precipitable water values (>50 mm) and embedded deep convection on their southern and eastern sides. Catastrophic flooding can occur when gyre cyclonic circulations interact with the topography of Central America. A Central American gyre climatology including gyre frequency over the TC season and individual gyre duration will be presented. This climatology is then used to craft a gyre composite using previous gyre cases from 1980-2010. Particular attention will be given to the common synoptic and sub-synoptic scale features that precede and take place during gyre formation. This includes the role that intraseasonal and interannual circulations such as the Madden-Julian Oscillation (MJO) and El Nino-Southern Oscillation (ENSO) might play in gyre development. TC genesis events within gyre circulations will also be highlighted and examined further. Finally, the results of a September 2010 case study will be used to illustrate the impact that Central American

  10. Northwest Atlantic Regional Climatology (NCEI Accession 0155889)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To provide an improved oceanographic foundation and reference for multi-disciplinary studies of the Northwest Atlantic Ocean, NCEI Regional Climatology Team...

  11. Global Daily Climatology Network: Kazakhstan subset

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a compilation of in situ daily meteorological observations for Kazakhstan within the framework of joint efforts to create Global Daily Climatology...

  12. U.S. Annual Climatological Summaries

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Annual Climatological Summary contains historical monthly and annual summaries for over 8000 U.S. locations. Observing stations are located in the United States of...

  13. Quality Controlled Local Climatological Data (QCLCD) Publication

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Quality Controlled Local Climatological Data (QCLCD) contains summaries from major airport weather stations that include a daily account of temperature extremes,...

  14. Climatology of salt transitions and implications for stone weathering

    Energy Technology Data Exchange (ETDEWEB)

    Grossi, C.M., E-mail: c.grossi-sampedro@uea.ac.uk [School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ (United Kingdom); Brimblecombe, P. [School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ (United Kingdom); Menendez, B. [Geosciences et Environnement Cergy, Universite de Cergy-Pontoise 95031 Cergy-Pontoise cedex (France); Benavente, D. [Lab. Petrologia Aplicada, Unidad Asociada UA-CSIC, Dpto. Ciencias de la Tierra y del Medio Ambiente, Universidad de Alicante, Alicante 03080 (Spain); Harris, I. [Climatic Research Unit, School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ (United Kingdom); Deque, M. [Meteo-France/CNRM, CNRS/GAME, 42 Avenue Coriolis, F-31057 Toulouse, Cedex 01 (France)

    2011-06-01

    This work introduces the notion of salt climatology. It shows how climate affects salt thermodynamic and the potential to relate long-term salt damage to climate types. It mainly focuses on specific sites in Western Europe, which include some cities in France and Peninsular Spain. Salt damage was parameterised using the number of dissolution-crystallisation events for unhydrated (sodium chloride) and hydrated (sodium sulphate) systems. These phase transitions have been calculated using daily temperature and relative humidity from observation meteorological data and Climate Change models' output (HadCM3 and ARPEGE). Comparing the number of transitions with meteorological seasonal data allowed us to develop techniques to estimate the frequency of salt transitions based on the local climatology. Results show that it is possible to associate the Koeppen-Geiger climate types with potential salt weathering. Temperate fully humid climates seem to offer the highest potential for salt damage and possible higher number of transitions in summer. Climates with dry summers tend to show a lesser frequency of transitions in summer. The analysis of temperature, precipitation and relative output from Climate Change models suggests changes in the Koeppen-Geiger climate types and changes in the patterns of salt damage. For instance, West Europe areas with a fully humid climate may change to a more Mediterranean like or dry climates, and consequently the seasonality of different salt transitions. The accuracy and reliability of the projections might be improved by simultaneously running multiple climate models (ensembles). - Research highlights: {yields} We introduce the notion of salt climatology for heritage conservation. {yields} Climate affects salt thermodynamics on building materials. {yields} We associate Koeppen-Geiger climate types with potential salt weathering. {yields} We offer future projections of salt damage in Western Europe due to climate change. {yields} Humid

  15. Observational and Dynamical Wave Climatologies. VOS vs Satellite Data

    Science.gov (United States)

    Grigorieva, Victoria; Badulin, Sergei; Chernyshova, Anna

    2013-04-01

    The understanding physics of wind-driven waves is crucially important for fundamental science and practical applications. This is why experimental efforts are targeted at both getting reliable information on sea state and elaborating effective tools of the sea wave forecasting. The global Visual Wave Observations and satellite data from the GLOBWAVE project of the European Space Agency are analyzed in the context of these two viewpoints. Within the first "observational" aspect we re-analyze conventional climatologies of all basic wave parameters for the last decades [5]. An alternative "dynamical" climatology is introduced as a tool of prediction of dynamical features of sea waves on global scales. The features of wave dynamics are studied in terms of one-parametric dependencies of wave heights on wave periods following the theoretical concept of self-similar wind-driven seas [3, 1, 4] and recently proposed approach to analysis of Voluntary Observing Ship (VOS) data [2]. Traditional "observational" climatologies based on VOS and satellite data collections demonstrate extremely consistent pictures for significant wave heights and dominant periods. On the other hand, collocated satellite and VOS data show significant differences in wave heights, wind speeds and, especially, in wave periods. Uncertainties of visual wave observations can explain these differences only partially. We see the key reason of this inconsistency in the methods of satellite data processing which are based on formal application of data interpolation methods rather than on up-to-date physics of wind-driven waves. The problem is considered within the alternative climatology approach where dynamical criteria of wave height-to-period linkage are used for retrieving wave periods and constructing physically consistent dynamical climatology. The key dynamical parameter - exponent R of one-parametric dependence Hs ~ TR shows dramatically less pronounced latitudinal dependence as compared to observed Hs

  16. A global satellite-assisted precipitation climatology

    Science.gov (United States)

    Funk, C.; Verdin, A.; Michaelsen, J.; Peterson, P.; Pedreros, D.; Husak, G.

    2015-10-01

    Accurate representations of mean climate conditions, especially in areas of complex terrain, are an important part of environmental monitoring systems. As high-resolution satellite monitoring information accumulates with the passage of time, it can be increasingly useful in efforts to better characterize the earth's mean climatology. Current state-of-the-science products rely on complex and sometimes unreliable relationships between elevation and station-based precipitation records, which can result in poor performance in food and water insecure regions with sparse observation networks. These vulnerable areas (like Ethiopia, Afghanistan, or Haiti) are often the critical regions for humanitarian drought monitoring. Here, we show that long period of record geo-synchronous and polar-orbiting satellite observations provide a unique new resource for producing high-resolution (0.05°) global precipitation climatologies that perform reasonably well in data-sparse regions. Traditionally, global climatologies have been produced by combining station observations and physiographic predictors like latitude, longitude, elevation, and slope. While such approaches can work well, especially in areas with reasonably dense observation networks, the fundamental relationship between physiographic variables and the target climate variables can often be indirect and spatially complex. Infrared and microwave satellite observations, on the other hand, directly monitor the earth's energy emissions. These emissions often correspond physically with the location and intensity of precipitation. We show that these relationships provide a good basis for building global climatologies. We also introduce a new geospatial modeling approach based on moving window regressions and inverse distance weighting interpolation. This approach combines satellite fields, gridded physiographic indicators, and in situ climate normals. The resulting global 0.05° monthly precipitation climatology, the Climate

  17. A global satellite assisted precipitation climatology

    Directory of Open Access Journals (Sweden)

    C. Funk

    2015-05-01

    Full Text Available Accurate representations of mean climate conditions, especially in areas of complex terrain, are an important part of environmental monitoring systems. As high-resolution satellite monitoring information accumulates with the passage of time, it can be increasingly useful in efforts to better characterize the earth's mean climatology. Current state-of-the-science products rely on complex and sometimes unreliable relationships between elevation and station-based precipitation records, which can result in poor performance in food and water insecure regions with sparse observation networks. These vulnerable areas (like Ethiopia, Afghanistan, or Haiti are often the critical regions for humanitarian drought monitoring. Here, we show that long period of record geo-synchronous and polar-orbiting satellite observations provide a unique new resource for producing high resolution (0.05° global precipitation climatologies that perform reasonably well in data sparse regions. Traditionally, global climatologies have been produced by combining station observations and physiographic predictors like latitude, longitude, elevation, and slope. While such approaches can work well, especially in areas with reasonably dense observation networks, the fundamental relationship between physiographic variables and the target climate variables can often be indirect and spatially complex. Infrared and microwave satellite observations, on the other hand, directly monitor the earth's energy emissions. These emissions often correspond physically with the location and intensity of precipitation. We show that these relationships provide a good basis for building global climatologies. We also introduce a new geospatial modeling approach based on moving window regressions and inverse distance weighting interpolation. This approach combines satellite fields, gridded physiographic indicators, and in situ climate normals. The resulting global 0.05° monthly precipitation climatology

  18. A global satellite assisted precipitation climatology

    Science.gov (United States)

    Funk, Christopher C.; Verdin, Andrew P.; Michaelsen, Joel C.; Pedreros, Diego; Husak, Gregory J.; Peterson, P.

    2015-01-01

    Accurate representations of mean climate conditions, especially in areas of complex terrain, are an important part of environmental monitoring systems. As high-resolution satellite monitoring information accumulates with the passage of time, it can be increasingly useful in efforts to better characterize the earth's mean climatology. Current state-of-the-science products rely on complex and sometimes unreliable relationships between elevation and station-based precipitation records, which can result in poor performance in food and water insecure regions with sparse observation networks. These vulnerable areas (like Ethiopia, Afghanistan, or Haiti) are often the critical regions for humanitarian drought monitoring. Here, we show that long period of record geo-synchronous and polar-orbiting satellite observations provide a unique new resource for producing high resolution (0.05°) global precipitation climatologies that perform reasonably well in data sparse regions. Traditionally, global climatologies have been produced by combining station observations and physiographic predictors like latitude, longitude, elevation, and slope. While such approaches can work well, especially in areas with reasonably dense observation networks, the fundamental relationship between physiographic variables and the target climate variables can often be indirect and spatially complex. Infrared and microwave satellite observations, on the other hand, directly monitor the earth's energy emissions. These emissions often correspond physically with the location and intensity of precipitation. We show that these relationships provide a good basis for building global climatologies. We also introduce a new geospatial modeling approach based on moving window regressions and inverse distance weighting interpolation. This approach combines satellite fields, gridded physiographic indicators, and in situ climate normals. The resulting global 0.05° monthly precipitation climatology, the Climate

  19. 3D/2D Registration of medical images

    OpenAIRE

    Tomaževič, D.

    2008-01-01

    The topic of this doctoral dissertation is registration of 3D medical images to corresponding projective 2D images, referred to as 3D/2D registration. There are numerous possible applications of 3D/2D registration in image-aided diagnosis and treatment. In most of the applications, 3D/2D registration provides the location and orientation of the structures in a preoperative 3D CT or MR image with respect to intraoperative 2D X-ray images. The proposed doctoral dissertation tries to find origin...

  20. Amphetamine self-administration attenuates dopamine D2 autoreceptor function.

    Science.gov (United States)

    Calipari, Erin S; Sun, Haiguo; Eldeeb, Khalil; Luessen, Deborah J; Feng, Xin; Howlett, Allyn C; Jones, Sara R; Chen, Rong

    2014-07-01

    Dopamine D2 autoreceptors located on the midbrain dopaminergic neurons modulate dopamine (DA) neuron firing, DA release, and DA synthesis through a negative-feedback mechanism. Dysfunctional D2 autoreceptors following repeated drug exposure could lead to aberrant DA activity in the ventral tegmental area (VTA) and projection areas such as nucleus accumbens (NAcc), promoting drug-seeking and -taking behavior. Therefore, it is important to understand molecular mechanisms underlying drug-induced changes in D2 autoreceptors. Here, we reported that 5 days of amphetamine (AMPH) self-administration reduced the ability of D2 autoreceptors to inhibit DA release in the NAcc as determined by voltammetry. Using the antibody-capture [(35)S]GTPγS scintillation proximity assay, we demonstrated for the first time that midbrain D2/D3 receptors were preferentially coupled to Gαi2, whereas striatal D2/D3 receptors were coupled equally to Gαi2 and Gαo for signaling. Importantly, AMPH abolished the interaction between Gαi2 and D2/D3 receptors in the midbrain while leaving striatal D2/D3 receptors unchanged. The disruption of the coupling between D2/D3 receptors and Gαi2 by AMPH is at least partially explained by the enhanced RGS2 (regulator of G-protein signaling 2) activity resulting from an increased RGS2 trafficking to the membrane. AMPH had no effects on the midbrain expression and trafficking of other RGS proteins such as RGS4 and RGS8. Our data suggest that midbrain D2/D3 receptors are more susceptible to AMPH-induced alterations. Reduced D2 autoreceptor function could lead to enhanced DA signaling and ultimately addiction-related behavior. RGS2 may be a potential non-dopaminergic target for pharmacological intervention of dysfunctional DA transmission and drug addiction.

  1. Amphetamine Self-Administration Attenuates Dopamine D2 Autoreceptor Function

    Science.gov (United States)

    Calipari, Erin S; Sun, Haiguo; Eldeeb, Khalil; Luessen, Deborah J; Feng, Xin; Howlett, Allyn C; Jones, Sara R; Chen, Rong

    2014-01-01

    Dopamine D2 autoreceptors located on the midbrain dopaminergic neurons modulate dopamine (DA) neuron firing, DA release, and DA synthesis through a negative-feedback mechanism. Dysfunctional D2 autoreceptors following repeated drug exposure could lead to aberrant DA activity in the ventral tegmental area (VTA) and projection areas such as nucleus accumbens (NAcc), promoting drug-seeking and -taking behavior. Therefore, it is important to understand molecular mechanisms underlying drug-induced changes in D2 autoreceptors. Here, we reported that 5 days of amphetamine (AMPH) self-administration reduced the ability of D2 autoreceptors to inhibit DA release in the NAcc as determined by voltammetry. Using the antibody-capture [35S]GTPγS scintillation proximity assay, we demonstrated for the first time that midbrain D2/D3 receptors were preferentially coupled to Gαi2, whereas striatal D2/D3 receptors were coupled equally to Gαi2 and Gαo for signaling. Importantly, AMPH abolished the interaction between Gαi2 and D2/D3 receptors in the midbrain while leaving striatal D2/D3 receptors unchanged. The disruption of the coupling between D2/D3 receptors and Gαi2 by AMPH is at least partially explained by the enhanced RGS2 (regulator of G-protein signaling 2) activity resulting from an increased RGS2 trafficking to the membrane. AMPH had no effects on the midbrain expression and trafficking of other RGS proteins such as RGS4 and RGS8. Our data suggest that midbrain D2/D3 receptors are more susceptible to AMPH-induced alterations. Reduced D2 autoreceptor function could lead to enhanced DA signaling and ultimately addiction-related behavior. RGS2 may be a potential non-dopaminergic target for pharmacological intervention of dysfunctional DA transmission and drug addiction. PMID:24513972

  2. Gulf of Mexico Regional Climatology (NCEI Accession 0123320)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Gulf of Mexico Regional Climatology is a set of objectively analyzed climatological fields of temperature, salinity, oxygen, phosphate, silicate, and nitrate at...

  3. Dispersion climatology in a coastal zone

    DEFF Research Database (Denmark)

    Larsen, Søren Ejling; Gryning, Sven-Erik

    1986-01-01

    system should be used to describe the dispersion. This dispersion classification scheme is used to organize 3 years of data from two meteorological masts, one placed directly at a shoreline and the other roughly 1 km inland. Differences in the dispersion climatology over land and water are studied...

  4. New dynamic NNORSY ozone profile climatology

    Directory of Open Access Journals (Sweden)

    A. K. Kaifel

    2012-01-01

    Full Text Available Climatological ozone profile data are widely used as a-priori information for total ozone using DOAS type retrievals as well as for ozone profile retrieval using optimal estimation, for data assimilation or evaluation of 3-D chemistry-transport models and a lot of other applications in atmospheric sciences and remote sensing. For most applications it is important that the climatology represents not only long term mean values but also the links between ozone and dynamic input parameters. These dynamic input parameters should be easily accessible from auxiliary datasets or easily measureable, and obviously should have a high correlation with ozone. For ozone profile these parameters are mainly total ozone column and temperature profile data. This was the outcome of a user consultation carried out in the framework of developing a new, dynamic ozone profile climatology.

    The new ozone profile climatology is based on the Neural Network Ozone Retrieval System (NNORSY widely used for ozone profile retrieval from UV and IR satellite sounder data. NNORSY allows implicit modelling of any non-linear correspondence between input parameters (predictors and ozone profile target vector. This paper presents the approach, setup and validation of a new family of ozone profile climatologies with static as well as dynamic input parameters (total ozone and temperature profile. The neural network training relies on ozone profile measurement data of well known quality provided by ground based (ozonesondes and satellite based (SAGE II, HALOE, and POAM-III measurements over the years 1995–2007. In total, four different combinations (modes for input parameters (date, geolocation, total ozone column and temperature profile are available.

    The geophysical validation spans from pole to pole using independent ozonesonde, lidar and satellite data (ACE-FTS, AURA-MLS for individual and time series comparisons as well as for analysing the vertical and meridian

  5. A novel tropopause-related climatology of ozone profiles

    NARCIS (Netherlands)

    Sofieva, V.F.; Tamminen, J.; Kyrola, E.; Mielonen, T.; Veefkind, J.P.; Hassler, B.; Bodeker, G.E.

    2014-01-01

    A new ozone climatology, based on ozonesonde and satellite measurements, spanning the altitude region between the earth's surface and ~60 km is presented (TpO3 climatology). This climatology is novel in that the ozone profiles are categorized according to calendar month, latitude and local tropopaus

  6. 7 CFR 15d.2 - Discrimination prohibited.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Discrimination prohibited. 15d.2 Section 15d.2... THE UNITED STATES DEPARTMENT OF AGRICULTURE § 15d.2 Discrimination prohibited. (a) No agency, officer... participation in, deny the benefits of, or subject to discrimination any person in the United States under any...

  7. Climatology of local flow patterns around Basel

    Energy Technology Data Exchange (ETDEWEB)

    Weber, R.O. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-06-01

    Recently a method has been developed to classify local-scale flow patterns from the wind measurements at a dense network of stations. It was found that in the MISTRAL area around Basel a dozen characteristic flow patterns occur. However, as the dense network of stations ran only during one year, no reliable climatology can be inferred from these data, especially the annual cycle of the flow patterns is not well determined from a single year of observations. As there exist several routinely operated stations in and near the MISTRAL area, a method was searched to identify the local flow patterns from the observations at the few routine stations. A linear discriminant analysis turned out to be the best method. Based of data from 11 stations which were simultaneously operated during 1990-1995 a six-year climatology of the flow patterns could be obtained. (author) 1 fig., 1 tab., 3 refs.

  8. Results of large scale wind climatologically estimations

    Directory of Open Access Journals (Sweden)

    Andrea Kircsi

    2008-05-01

    Full Text Available The aim of this article is to describe theparticular field of climatology which analyzes airmovement characteristics regarding utilization of windfor energy generation. The article describes features ofwind energy potential available in Hungary compared towind conditions in other areas of the northern quartersphere in order to assist the wind energy use developmentin Hungary. Information on wind climate gives a solidbasis for financial and economic decisions ofstakeholders in the field of wind energy utilization.

  9. Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin.

    Science.gov (United States)

    Galan-Rodriguez, Beatriz; Martin, Elodie; Brouillet, Emmanuel; Déglon, Nicole; Betuing, Sandrine; Caboche, Jocelyne

    2017-01-01

    Huntington's disease, an inherited neurodegenerative disorder, results from abnormal polyglutamine extension in the N-terminal region of the huntingtin protein. This mutation causes preferential degeneration of striatal projection neurons. We previously demonstrated, in vitro, that dopaminergic D2 receptor stimulation acted in synergy with expanded huntingtin to increase aggregates formation and striatal death through activation of the Rho/ROCK signaling pathway. In vivo, in a lentiviral-mediated model of expanded huntingtin expression in the rat striatum, we found that the D2 antagonist haloperidol protects striatal neurons against expanded huntingtin-mediated toxicity. Two variant transcripts are generated by alternative splicing of the of D2 receptor gene, the D2R-Long and the D2R-Short, which are thought to play different functional roles. We show herein that overexpression of D2R-Short, but not D2R-Long in cell lines is associated with activation of the RhoA/ROCK signaling pathway. In striatal neurons in culture, the selective D2 agonist Quinpirole triggers phosphorylation of cofilin, a downstream effector of ROCK, which is abrogated by siRNAs that knockdown both D2R-Long and D2R-Short, but not by siRNAs targeting D2R-Long alone. Aggregate formation and neuronal death induced by expanded huntingtin, were potentiated by Quinpirole. This D2 agonist-mediated effect was selectively inhibited by the siRNA targeting both D2R-Long and D2R-Short but not D2R-Long alone. Our data provide evidence for a specific coupling of D2R-Short to the RhoA/ROCK/cofilin pathway, and its involvement in striatal vulnerability to expanded huntingtin. A new route for targeting Rho-ROCK signaling in Huntington's disease is unraveled with our findings.

  10. A methodological critique on using temperature-conditioned resampling for climate projections as in the paper of Gerstengarbe et al. (2013) winter storm- and summer thunderstorm-related loss events in Theoretical and Applied Climatology (TAC)

    Science.gov (United States)

    Wechsung, Frank; Wechsung, Maximilian

    2016-11-01

    The STatistical Analogue Resampling Scheme (STARS) statistical approach was recently used to project changes of climate variables in Germany corresponding to a supposed degree of warming. We show by theoretical and empirical analysis that STARS simply transforms interannual gradients between warmer and cooler seasons into climate trends. According to STARS projections, summers in Germany will inevitably become dryer and winters wetter under global warming. Due to the dominance of negative interannual correlations between precipitation and temperature during the year, STARS has a tendency to generate a net annual decrease in precipitation under mean German conditions. Furthermore, according to STARS, the annual level of global radiation would increase in Germany. STARS can be still used, e.g., for generating scenarios in vulnerability and uncertainty studies. However, it is not suitable as a climate downscaling tool to access risks following from changing climate for a finer than general circulation model (GCM) spatial scale.

  11. Vitamine D2 ou vitamine D3?

    OpenAIRE

    MISTRETTA, Virginie; Delanaye, Pierre; Chapelle, Jean-Paul; Souberbielle, Jean-Claude; Cavalier, Etienne

    2008-01-01

    PURPOSE: Nearly one billion people around the world are deficient in vitamin D and need to be supplemented. Vitamin D is available in medicines and fortified foods. It is available in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). KEY POINTS: The pharmacopeiae consider these steroid hormones as equivalent and interchangeable. However, several studies have showed that serum level of 25(OH)D is increased more effectively with vitamin D3 than vitamin D2. Vitamin D2 has ...

  12. Main: D2GMAUX28 [PLACE

    Lifescience Database Archive (English)

    Full Text Available D2GMAUX28 S000329 7-Sep-2000 (last modified) seki D2; DNase I protected sequence fo...und in the soybean (G.m.) auxin responsive gene, Aux28, promoter; Located between -703 and -716; A/T-rich sequence; Auxin; Aux28; soybean (Glycine max) ATTTATATAAAT ...

  13. Development of regional future climate change scenarios in South America using the Eta CPTEC/HadCM3 climate change projections: climatology and regional analyses for the Amazon, Sao Francisco and the Parana River basins

    Energy Technology Data Exchange (ETDEWEB)

    Marengo, Jose A.; Chou, Sin Chan; Alves, Lincoln M.; Pesquero, Jose F.; Soares, Wagner R.; Santos, Daniel C.; Lyra, Andre A.; Sueiro, Gustavo; Chagas, Diego J.; Gomes, Jorge L.; Bustamante, Josiane F.; Tavares, Priscila [National Institute for Space Research (INPE) Cachoeira Paulista, Sao Paulo (Brazil); Kay, Gillian; Betts, Richard [UK Met Office Hadley Centre, Exeter, Devon (United Kingdom)

    2012-05-15

    The objective of this study is to assess the climate projections over South America using the Eta-CPTEC regional model driven by four members of an ensemble of the Met Office Hadley Centre Global Coupled climate model HadCM3. The global model ensemble was run over the twenty-first century according to the SRES A1B emissions scenario, but with each member having a different climate sensitivity. The four members selected to drive the Eta-CPTEC model span the sensitivity range in the global model ensemble. The Eta-CPTEC model nested in these lateral boundary conditions was configured with a 40-km grid size and was run over 1961-1990 to represent baseline climate, and 2011-2100 to simulate possible future changes. Results presented here focus on austral summer and winter climate of 2011-2040, 2041-2070 and 2071-2100 periods, for South America and for three major river basins in Brazil. Projections of changes in upper and low-level circulation and the mean sea level pressure (SLP) fields simulate a pattern of weakening of the tropical circulation and strengthening of the subtropical circulation, marked by intensification at the surface of the Chaco Low and the subtropical highs. Strong warming (4-6 C) of continental South America increases the temperature gradient between continental South America and the South Atlantic. This leads to stronger SLP gradients between continent and oceans, and to changes in moisture transport and rainfall. Large rainfall reductions are simulated in Amazonia and Northeast Brazil (reaching up to 40%), and rainfall increases around the northern coast of Peru and Ecuador and in southeastern South America, reaching up to 30% in northern Argentina. All changes are more intense after 2040. The Precipitation-Evaporation (P-E) difference in the A1B downscaled scenario suggest water deficits and river runoff reductions in the eastern Amazon and Sao Francisco Basin, making these regions susceptible to drier conditions and droughts in the future

  14. A climatology of visible surface reflectance spectra

    Science.gov (United States)

    Zoogman, Peter; Liu, Xiong; Chance, Kelly; Sun, Qingsong; Schaaf, Crystal; Mahr, Tobias; Wagner, Thomas

    2016-09-01

    We present a high spectral resolution climatology of visible surface reflectance as a function of wavelength for use in satellite measurements of ozone and other atmospheric species. The Tropospheric Emissions: Monitoring of Pollution (TEMPO) instrument is planned to measure backscattered solar radiation in the 290-740 nm range, including the ultraviolet and visible Chappuis ozone bands. Observation in the weak Chappuis band takes advantage of the relative transparency of the atmosphere in the visible to achieve sensitivity to near-surface ozone. However, due to the weakness of the ozone absorption features this measurement is more sensitive to errors in visible surface reflectance, which is highly variable. We utilize reflectance measurements of individual plant, man-made, and other surface types to calculate the primary modes of variability of visible surface reflectance at a high spectral resolution, comparable to that of TEMPO (0.6 nm). Using the Moderate-resolution Imaging Spectroradiometer (MODIS) Bidirection Reflectance Distribution Function (BRDF)/albedo product and our derived primary modes we construct a high spatial resolution climatology of wavelength-dependent surface reflectance over all viewing scenes and geometries. The Global Ozone Monitoring Experiment-2 (GOME-2) Lambertian Equivalent Reflectance (LER) product provides complementary information over water and snow scenes. Preliminary results using this approach in multispectral ultraviolet+visible ozone retrievals from the GOME-2 instrument show significant improvement to the fitting residuals over vegetated scenes.

  15. Critical analysis of documentary sources for Historical Climatology of Northern Portugal (17th-19th centuries)

    Science.gov (United States)

    Amorim, Inês; Sousa Silva, Luís; Garcia, João Carlos

    2017-04-01

    Critical analysis of documentary sources for Historical Climatology of Northern Portugal (17th-19th centuries) Inês Amorim CITCEM, Department of History, Political and International Studies, U. of Porto, Portugal. Luís Sousa Silva CITCEM, PhD Fellowship - FCT. João Carlos Garcia CIUHCT, Geography Department, U. of Porto, Portugal. The first major national project on Historical Climatology in Portugal, called "KLIMHIST: Reconstruction and model simulations of past climate in Portugal using documentary and early instrumental sources (17th-19th centuries)", ended in September 2015, coordinated by Maria João Alcoforado. This project began in March 2012 and counted on an interdisciplinary team of researchers from four Portuguese institutions (Centre of Geographical Studies, University of Trás-os-Montes and Alto Douro, University of Porto, and University of Évora), from different fields of knowledge (Geography, History, Biology, Climatology and Meteorology). The team networked and collaborated with other international research groups on Climate Change and Historical Climatology, resulting in several publications. This project aimed to reconstruct thermal and rainfall patterns in Portugal between the 17th and 19th centuries, as well as identify the main hydrometeorological extremes that occurred over that period. The basic methodology consisted in combining information from different types of anthropogenic sources (descriptive and instrumental) and natural sources (tree rings and geothermal holes), so as to develop climate change models of the past. The data collected were stored in a digital database, which can be searched by source, date, location and type of event. This database, which will be made publically available soon, contains about 3500 weather/climate-related records, which have begun to be studied, processed and published. Following this seminal project, other initiatives have taken place in Portugal in the area of Historical Climatology, namely a Ph

  16. On reconstruction of time series in climatology

    Directory of Open Access Journals (Sweden)

    V. Privalsky

    2015-10-01

    Full Text Available The approach to time series reconstruction in climatology based upon cross-correlation coefficients and regression equations is mathematically incorrect because it ignores the dependence of time series upon their past. The proper method described here for the bivariate case requires the autoregressive time- and frequency domains modeling of the time series which contains simultaneous observations of both scalar series with subsequent application of the model to restore the shorter one into the past. The method presents further development of previous efforts taken by a number of authors starting from A. Douglass who introduced some concepts of time series analysis into paleoclimatology. The method is applied to the monthly data of total solar irradiance (TSI, 1979–2014, and sunspot numbers (SSN, 1749–2014, to restore the TSI data over 1749–1978. The results of the reconstruction are in statistical agreement with observations.

  17. A hemispheric climatology of monsoon depressions

    Science.gov (United States)

    Hurley, J. V.; Boos, W.

    2012-12-01

    Monsoon depressions are large (1000-2000 km diameter) cyclonic low pressure systems having organized deep convection, best known for forming in the Bay of Bengal and migrating northwest over northern India in the monsoon trough. About 3 to 5 of these systems occur during each monsoon season, contributing about half of the Indian summer rainfall. Despite their importance as a precipitation source, their dynamics are poorly constrained. Furthermore, although they do occur elsewhere, such as around Australia and in the southern Indian Ocean, there does not exist a collective inventory of these systems outside of the Bay of Bengal region. Here we present a climatology of monsoon depressions produced from the ERA-Interim Reanalysis. Feature tracks are identified using an automated tracking algorithm (K. Hodges' TRACK code) applied to the 850 hPa relative vorticity field for local summer, 1989 to 2003. Using criteria based on relative vorticity and sea level pressure, cyclonic low pressure systems are separated into different intensity categories, one of which corresponds to the definition for monsoon depressions used by the India Meteorological Department. The resultant distribution of storms obtained for the Bay of Bengal region compares well with a previously compiled climatology of monsoon depressions that was limited to the region surrounding India. Having validated our ability to identify monsoon depressions in their classic genesis region near India, we then extend the methods to include the western Pacific, Australia, and the southern Indian Ocean. Track distributions and composite structures of monsoon depressions for these different regions will be presented.

  18. Constructing an AIRS Climatology for Data Visualization and Analysis to Serve the Climate Science and Application Communities

    Science.gov (United States)

    Ding, Feng; Keim, Elaine; Hearty, Thomas J.; Wei, Jennifer; Savtchenko, Andrey; Theobald, Michael; Vollmer, Bruce

    2016-01-01

    The NASA Goddard Earth Sciences Data and Information Services Center (GES DISC) is the home of processing, archiving, and distribution services for NASA sounders: the present Aqua AIRS mission and the succeeding SNPP CrIS mission. The AIRS mission is entering its 15th year of global observations of the atmospheric state, including temperature and humidity profiles, outgoing longwave radiation, cloud properties, and trace gases. The GES DISC, in collaboration with the AIRS Project, released product from the version 6 algorithm in early 2013. Giovanni, a Web-based application developed by the GES DISC, provides a simple and intuitive way to visualize, analyze, and access vast amounts of Earth science remote sensing data without having to download the data. Most important variables from version 6 AIRS product are available in Giovanni. We are developing a climatology product using 14-year AIRS retrievals. The study can be a good start for the long term climatology from NASA sounders: the AIRS and the succeeding CrIS. This presentation will show the impacts to the climatology product from different aggregation methods. The climatology can serve climate science and application communities in data visualization and analysis, which will be demonstrated using a variety of functions in version 4 Giovanni. The highlights of these functions include user-defined monthly and seasonal climatology, inter annual seasonal time series, anomaly analysis.

  19. Training programme for the dissemination of climatological and meteorological applications using GIS technology

    Directory of Open Access Journals (Sweden)

    T. De Filippis

    2006-01-01

    Full Text Available IBIMET-CNR is involved in making different research projects and in managing operational programmes on national and international level and has acquired a relevant training competence to sustain partner countries and improve their methodological and operational skills by using innovative tools, such as Geographical Information Systems focused on the development of meteorological and climatological applications. Training activities are mainly addressed to National Meteorological and Hydrological Services of Partner-Countries and/or to other Specialized Centers in the frame of Cooperation Programmes promoted by the Italian Ministry of Foreign Affairs mainly in favour of the Less Developing Countries (LDC of World Meteorological Organisation (WMO Regional Association I (Africa. The Institute, as a branch of the WMO-Regional Meteorological Training Centre for Region VI (Europe, organizes also international training courses of high-level in Meteorology, Climatology and Remote Sensing applied to environment and agriculture fields. Moreover, considering the increasing evolution of the GIS functions for meteorological information users, IBIMET has promoted in 2005 the EU COST Action 719 Summer School on "GIS applications in meteorology and climatology''. The paper offers an overview of the main institute training programmes organised to share the results of research activities and operational projects, through the exploitation of innovative technologies and tools like GIS.

  20. Training programme for the dissemination of climatological and meteorological applications using GIS technology

    Science.gov (United States)

    de Filippis, T.; di Vecchia, A.; Maracchi, G.; Sorani, F.

    2006-06-01

    IBIMET-CNR is involved in making different research projects and in managing operational programmes on national and international level and has acquired a relevant training competence to sustain partner countries and improve their methodological and operational skills by using innovative tools, such as Geographical Information Systems focused on the development of meteorological and climatological applications. Training activities are mainly addressed to National Meteorological and Hydrological Services of Partner-Countries and/or to other Specialized Centers in the frame of Cooperation Programmes promoted by the Italian Ministry of Foreign Affairs mainly in favour of the Less Developing Countries (LDC) of World Meteorological Organisation (WMO) Regional Association I (Africa). The Institute, as a branch of the WMO-Regional Meteorological Training Centre for Region VI (Europe), organizes also international training courses of high-level in Meteorology, Climatology and Remote Sensing applied to environment and agriculture fields. Moreover, considering the increasing evolution of the GIS functions for meteorological information users, IBIMET has promoted in 2005 the EU COST Action 719 Summer School on "GIS applications in meteorology and climatology''. The paper offers an overview of the main institute training programmes organised to share the results of research activities and operational projects, through the exploitation of innovative technologies and tools like GIS.

  1. International Satellite Cloud Climatology Project, D-Series (Superseded)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — ISCCP D-Series has been superseded by a newer version. Users should not use ISCCP D-Series except in rare cases (e.g., when reproducing previous studies that used...

  2. Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria

    DEFF Research Database (Denmark)

    Kranendijk, Martijn; Struys, Eduard A; Gibson, K Michael;

    2010-01-01

    We performed molecular, enzyme, and metabolic studies in 50 patients with D-2-hydroxyglutaric aciduria (D-2-HGA) who accumulated D-2-hydroxyglutarate (D-2-HG) in physiological fluids. Presumed pathogenic mutations were detected in 24 of 50 patients in the D-2-hydroxyglutarate dehydrogenase (D2HGD...

  3. A climatological network for regional climate monitoring in Sardinia.

    Science.gov (United States)

    Delitala, Alessandro M. S.

    2016-04-01

    In recent years the Region of Sardinia has been working to set-up a Regional Climatological Network of surface stations, in order to monitor climate (either stationary or changing) at sub-synoptic scale and in order to make robust climatological information available to researchers and to local stake-holders. In order to do that, an analysis of long climatological time series has been performed on the different historical networks of meteorological stations that existed over the past two centuries. A set of some hundreds of stations, with about a century of observations of daily precipitation, was identified. An important subset of them was also defined, having long series of observations of temperature, wind, pressure and other quantities. Specific investments were made on important stations sites where observations had been carried for decades, but where the climatological stations did not exist anymore. In the present talk, the Regional Climatological Network of Sardinia will be presented and its consistency discussed. Specific attention will be given to the most important climatological stations which have got more than a century of observations of meteorological quantities. Critical issues of the Regional Climatological Network, like relocation of stations and inhomogeneity of data due to instrumental changes or environmental modifications, will be discussed.

  4. THz spectroscopy of D2H+

    Science.gov (United States)

    Yu, S.; Pearson, J. C.; Amano, T.; Matsushima, F.

    2017-01-01

    We extended the measurements of the rotational transitions of D2H+ up to 3 THz by using the JPL frequency multiplier chains and a TuFIR system at Toyama. D2H+ was generated in an extended negative glow discharge cell cooled to liquid nitrogen temperature. We observed five new THz lines. All the available rotational transition frequencies together with the combination differences derived from the three fundamental bands were subject to least square analysis to determine the molecular constants. New THz measurements are definitely useful for better characterization of spectroscopic properties. The improved molecular constants provide better predictions of other unobserved rotational transitions.

  5. Concept and Model - Kiwi project deliverable D2.8

    DEFF Research Database (Denmark)

    Durao, Frederico; Dolog, Peter

    2009-01-01

    hypermedia and semantic web techniques have been applied for software customization. •    Technically describing how personal information can be utilised as a decision on recommending content items based on tags, grouping individuals based on similar interests and roles, performing personalised search...

  6. Lightning climatology in the Congo Basin

    Science.gov (United States)

    Soula, S.; Kasereka, J. Kigotsi; Georgis, J. F.; Barthe, C.

    2016-09-01

    The lightning climatology of the Congo Basin including several countries of Central Africa is analysed in detail for the first time. It is based on data from the World Wide Lightning Location Network (WWLLN), for the period from 2005 to 2013. A comparison of these data with Lightning Imaging Sensor (LIS) data for the same period shows the relative detection efficiency of the WWLLN (DE) in the 2500 km × 2500 km region increases from about 1.70% in the beginning of the period to 5.90% in 2013, and it is in agreement with previous results for other regions of the world. However, the increase of DE is not uniform over the whole region. The average monthly flash rate describes an annual cycle with a strong activity from October to March and a low one from June to August, associated with the ITCZ migration but not exactly symmetrical on both sides of the equator. The zonal distribution of the lightning flashes exhibits a maximum between 1°S and 2°S and about 56% of the flashes are located south of the equator in the 10°S-10°N interval. The diurnal evolution of the flash rate has a maximum between 1400 and 1700 UTC, according to the reference year. The annual flash density and number of stormy days show a sharp maximum localized in the eastern part of Democratic Republic of Congo (DRC) regardless of the reference year and the period of the year. These maxima reach 12.86 fl km- 2 and 189 days, respectively, in 2013, and correspond to a very active region located at the rear of the Virunga mountain range at altitudes that exceed 3000 m. The presence of these mountains plays a role in the thunderstorm development along the year. The estimation of this local maximum of the lightning density by taking into account the DE, leads to a value consistent with that of the global climatology by Christian et al. (2003).

  7. Sprite Climatology in the Eastern Mediterranean Region

    Science.gov (United States)

    Yair, Yoav; Price, Colin; Katzenelson, Dor; Rosenthal, Neta; Rubanenko, Lior; Ben-Ami, Yuval; Arnone, Enrico

    2015-04-01

    We present statistical analysis of 436 sprites observed in 7 winter campaigns from 2006/7-2012/13. Results show a clear peak in the frequency of sprite detections, with maximum values (reports of winter sprites over the Sea of Japan and summer ones in central Europe. Other shapes such as trees, wishbones, etc. appear quite rarely. Single element events constitute 16.5% of observations, with 83.5% containing 2 elements or more. Clusters of homogeneous types are slightly more frequent than mixed ones (55%). Our observations suggest winter East Mediterranean thunderstorms to have a vertical structure that is an intermediate type between high tropical convective systems and the lower cloud-top cells in winter thunderstorms over the Sea of Japan. The climatology shows that the Eastern Mediterranean is a major sprite producer during Northern Hemisphere winter, and thus the existing and future optical observation infrastructure in Israel offers ground-based coverage for upcoming space missions that aim to map global sprite activity.

  8. On the Analysis of the Climatology of Cloudiness of the Arabian Peninsula

    Science.gov (United States)

    Yousef, L. A.; Temimi, M.

    2015-12-01

    This study aims to determine the climatology of cloudiness over the Arabian Peninsula. The determined climatology will assist solar energy resource assessment in the region. The seasonality of cloudiness and its spatial variability will also help guide several cloud seeding operational experiments in the region. Cloud properties from the International Satellite Cloud Climatology Project (ISCCP) database covering the time period from 1983 through 2009 are analyzed. Time series of low, medium, high, and total cloud amounts are investigated, in addition to cloud optical depth and total column water vapor. Initial results show significant decreasing trends in the total and middle cloud amounts, both annually and seasonally, at a 95% confidence interval. The relationship between cloud amounts and climate oscillations known to affect the region is explored. Climate indices exhibiting significant correlations with the total cloud amounts include the Pacific Decadal Oscillation (PDO) index. The study also includes a focus on the United Arab Emirates (UAE), comparing the inferred cloudiness data to in situ rainfall measurements taken from rain gauges across the UAE. To assess the impact of cloudiness on solar power resources in the country, time series of cloud amounts and Direct Normal Irradiance (DNI), obtained from the UAE Solar Atlas, are compared.

  9. Global Historical Climatology Network - Daily (GHCN-Daily), Version 3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Global Historical Climatology Network - Daily (GHCN-Daily) dataset integrates daily climate observations from approximately 30 different data sources. Version 3...

  10. Historical Climatology In Europe. The State Of The Art

    Energy Technology Data Exchange (ETDEWEB)

    Brazdil, R. [Institute of Geography, Masaryk University, Kotlarska 2, CZ-611 37 Brno (Czech Republic); Pfister, C. [Institute of History/NCCR Climate, University of Bern, Unitobler, CH-3000 Bern 9 (Switzerland); Wanner, H.; Luterbacher, J. [NCCR Climate, University of Bern, Hallerstrasse 12, CH-3012 Bern (Switzerland); Von Storch, H. [GKSS-Research-Center, Max Planck Strasse 1, D-21502 Geesthacht (Germany)

    2005-06-01

    This paper discusses the state of European research in historical climatology. This field of science and an overview of its development are described in detail. Special attention is given to the documentary evidence used for data sources, including its drawbacks and advantages. Further, methods and significant results of historical-climatological research, mainly achieved since 1990, are presented. The main focus concentrates on data, methods, definitions of the 'Medieval Warm Period' and the 'Little Ice Age', synoptic interpretation of past climates, climatic anomalies and natural disasters, and the vulnerability of economies and societies to climate as well as images and social representations of past weather and climate. The potential of historical climatology for climate modelling research is discussed briefly. Research perspectives in historical climatology are formulated with reference to data, methods, interdisciplinarity and impacts.

  11. Hanford Site Climatological Summary 2004 with Historical Data

    Energy Technology Data Exchange (ETDEWEB)

    Hoitink, Dana J.; Burk, Kenneth W.; Ramsdell, James V.; Shaw, William J.

    2005-06-03

    This document presents the climatological data measured on the DOE Hanford Site for calendar year 2004. This report contains updated historical information for temperature, precipitation, wind, and normal and extreme values of temperature, and precipitation.

  12. AFSC/ABL: Auke Bay Climatology 1959-2013

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data set includes available climatological and related physical environmental records for Auke Bay, Auke Creek and Auke Lake beginning in 1959. Daily high and low...

  13. Global Historical Climatology Network - Monthly (GHCN-M), Version 3

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Since the early 1990s the Global Historical Climatology Network-Monthly (GHCN-M) dataset has been an internationally recognized source of data for the study of...

  14. Seasonal Variation of Provitamin D2 and Vitamin D2 in Perennial Ryegrass (Lolium perenne L.)

    DEFF Research Database (Denmark)

    Jäpelt, Rie Bak; Didion, Thomas; Smedsgaard, Jørn

    2011-01-01

    Ergosterol (provitamin D(2)) is converted to vitamin D(2) in grass by exposure to UV light. Six varieties of perennial ryegrass (Lolium perenne L.) were harvested four times during the season, and the contents of vitamin D(2) and ergosterol were analyzed by a sensitive and selective liquid...... chromatography tandem mass spectrometry method. Weather factors were recorded, and a principal component analysis was performed to study which factors were important for the formation of vitamin D(2). The results suggest that a combination of weather factors is involved and that the contents of ergosterol...... and vitamin D(2) change more than a factor of 10 during the season. These results demonstrate that grass potentially can be a significant source of vitamin D for grazing animals and animals fed on silage and hay....

  15. Peer-tutoring educational experiences about meteorological and climatological issues in Friuli Venezia Giulia (Italy)

    Science.gov (United States)

    Nordio, Sergio; Flapp, Federica

    2017-04-01

    The aim of this work is to present some experiences of intergenerational education about meteorology and climatology issues carried out with school pupils from 6 to 19 years old, through peer-tutoring methodology. These experiences started in 2003 and each year the project involves about 500 students in Friuli Venezia Giulia region (about 8.000 km2) in northeastern Italy. A group of volunteers (older students from upper secondary school, 17-19 years old) play the role of "tutor": they receive supplementary training on meteorology and climatology, and then, during students' meetings and/or public events, they teach younger pupils how to use meteorological instruments (thermometer, hygrometer, barometer, anemometer, rain gages, etc.) and they carry out interactive experiences such as "game-experiments", to better understand some meteorological concepts, like density of fluids, and some climatological notions, like the effects of climate change with an exhibit that simulates the greenhouse effect. They also do some meteorological forecasting exercises, using meteorological maps, as if they were actual forecasters. All these activities are addressed to pupils from primary (age 6-11) and lower secondary schools (age 11-14), and both tutors and their younger "apprentices" are not only cognitively, but also emotionally involved in such learning experiences. As a second step of this educational process, after consolidating the above mentioned peer-tutoring activities, high school students hare being actively involved in developing visual tools - e.g. video-clips, interviews and cartoons - in order to communicate climate change issues in the most effective way to younger pupils. Keywords: meteorology, climatology, climate change, schools, education, communication.

  16. Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers

    Science.gov (United States)

    Navarro, Gemma; Moreno, Estefania; Bonaventura, Jordi; Brugarolas, Marc; Farré, Daniel; Aguinaga, David; Mallol, Josefa; Cortés, Antoni; Casadó, Vicent; Lluís, Carmen; Ferre, Sergi

    2013-01-01

    Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine receptors. Cocaine is able to subvert these balanced inputs by altering the cell signaling of these two pathways such that D1 reward seeking pathway dominates. Here, we provide an explanation at the cellular and biochemical level how cocaine may achieve this. Exploring the effect of cocaine on dopamine D2 receptors function, we present evidence of σ1 receptor molecular and functional interaction with dopamine D2 receptors. Using biophysical, biochemical, and cell biology approaches, we discovered that D2 receptors (the long isoform of the D2 receptor) can complex with σ1 receptors, a result that is specific to D2 receptors, as D3 and D4 receptors did not form heteromers. We demonstrate that the σ1-D2 receptor heteromers consist of higher order oligomers, are found in mouse striatum and that cocaine, by binding to σ1 -D2 receptor heteromers, inhibits downstream signaling in both cultured cells and in mouse striatum. In contrast, in striatum from σ1 knockout animals these complexes are not found and this inhibition is not seen. Taken together, these data illuminate the mechanism by which the initial exposure to cocaine can inhibit signaling via D2 receptor containing neurons, destabilizing the delicate signaling balance influencing drug seeking that emanates from the D1 and D2 receptor containing neurons in the brain. PMID:23637801

  17. Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers.

    Directory of Open Access Journals (Sweden)

    Gemma Navarro

    Full Text Available Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine receptors. Cocaine is able to subvert these balanced inputs by altering the cell signaling of these two pathways such that D1 reward seeking pathway dominates. Here, we provide an explanation at the cellular and biochemical level how cocaine may achieve this. Exploring the effect of cocaine on dopamine D2 receptors function, we present evidence of σ1 receptor molecular and functional interaction with dopamine D2 receptors. Using biophysical, biochemical, and cell biology approaches, we discovered that D2 receptors (the long isoform of the D2 receptor can complex with σ1 receptors, a result that is specific to D2 receptors, as D3 and D4 receptors did not form heteromers. We demonstrate that the σ1-D2 receptor heteromers consist of higher order oligomers, are found in mouse striatum and that cocaine, by binding to σ1 -D2 receptor heteromers, inhibits downstream signaling in both cultured cells and in mouse striatum. In contrast, in striatum from σ1 knockout animals these complexes are not found and this inhibition is not seen. Taken together, these data illuminate the mechanism by which the initial exposure to cocaine can inhibit signaling via D2 receptor containing neurons, destabilizing the delicate signaling balance influencing drug seeking that emanates from the D1 and D2 receptor containing neurons in the brain.

  18. Odin stratospheric proxy NOy measurements and climatology

    Directory of Open Access Journals (Sweden)

    D. Murtagh

    2008-10-01

    Full Text Available Five years of OSIRIS (Optical Spectrograph and InfraRed Imager System NO2 and SMR (Sub-millimetre and Millimetre Radiometer HNO3 observations from the Odin satellite, combined with data from a photochemical box model, have been used to construct a stratospheric proxy NOy data set including the gases: NO, NO2, HNO3, 2×N2O5 and ClONO2. This Odin NOy climatology is based on all daytime measurements and contains monthly mean and standard deviation, expressed as mixing ratio or number density, as function of latitude or equivalent latitude (5° bins on 17 vertical layers (altitude, pressure or potential temperature between 14 and 46 km. Comparisons with coincident NOy profiles from the Atmospheric Chemistry Experiment-Fourier Transform Spectrometer (ACE-FTS instrument were used to evaluate several methods to combine Odin observations with model data. This comparison indicates that the most appropriate merging technique uses OSIRIS measurements of NO2, scaled with model NO/NO2 ratios, to estimate NO. The sum of 2×N2O5 and ClONO2 is estimated from uncertainty-based weighted averages of scaled observations of SMR HNO3 and OSIRIS NO2. Comparisons with ACE-FTS suggest the precision (random error and accuracy (systematic error of Odin NOy profiles are about 15% and 20%, respectively. Further comparisons between Odin and the Canadian Middle Atmosphere Model (CMAM show agreement to within 20% and 2 ppb throughout most of the stratosphere except in the polar vortices. The combination of good temporal and spatial coverage, a relatively long data record, and good accuracy and precision make this a valuable NOy product for various atmospheric studies and model assessments.

  19. Odin stratospheric proxy NOy measurements and climatology

    Directory of Open Access Journals (Sweden)

    D. Murtagh

    2008-03-01

    Full Text Available Five years of OSIRIS (Optical Spectrograph and InfraRed Imager System NO2 and SMR (Sub-Millimetre Radiometer HNO3 observations from the Odin satellite, combined with data from a photochemical box model, have been used to construct a stratospheric proxy NOy data set including the gases: NO, NO2, HNO3, 2×N2O5 and CIONO2. This Odin NOy climatology is based on all daytime measurements and contains monthly mean and standard deviation, expressed as mixing ratio or number density, as function of latitude or equivalent latitude (5° bins on 17 vertical layers (altitude, pressure or potential temperature between 14 and 46 km. Comparisons with coincident NOy profiles from the Atmospheric Chemistry Experiment–Fourier Transform Spectrometer (ACE-FTS instrument were used to evaluate several methods to combine Odin observations with model data. This comparison indicates that the most appropriate merging technique uses OSIRIS measurements of NO2, scaled with model NO/NO2 ratios, to estimate NO. The sum of 2×N2O5 and CIONO2 is estimated from uncertainty-based weighted averages of scaled observations of SMR HNO3 and OSIRIS NO2. Comparisons with ACE-FTS suggest the precision (random error and accuracy (systematic error of Odin NOy profiles are about 15% and 20%, respectively. Further comparisons between Odin and the Canadian Middle Atmosphere Model (CMAM show agreement to within 20% and 2 ppb throughout most of the stratosphere except in the polar vortices. A particularly large disagreement within the Antarctic vortex in the upper stratosphere during spring indicates too strong descent of air in CMAM. The combination of good temporal and spatial coverage, a relatively long data record, and good accuracy and precision make this a valuable NOy product for various atmospheric studies and model assessments.

  20. A seasonal air transport climatology for Kenya

    Science.gov (United States)

    Gatebe, C. K.; Tyson, P. D.; Annegarn, H.; Piketh, S.; Helas, G.

    1999-06-01

    A climatology of air transport to and from Kenya has been developed using kinematic trajectory modeling. Significant months for trajectory analysis have been determined from a classification of synoptic circulation fields. Five-point back and forward trajectory clusters to and from Kenya reveal that the transport corridors to Kenya are clearly bounded and well defined. Air reaching the country originates mainly from the Saharan region and northwestern Indian Ocean of the Arabian Sea in the Northern Hemisphere and from the Madagascan region of the Indian Ocean in the Southern Hemisphere. Transport from each of these source regions show distinctive annual cycles related to the northeasterly Asian monsoon and the southeasterly trade wind maximum over Kenya in May. The Saharan transport in the lower troposphere is at a maximum when the subtropical high over northern Africa is strongly developed in the boreal winter. Air reaching Kenya between 700 and 500 hPa is mainly from Sahara and northwest Indian Ocean in the months of January and March, which gives way to southwest Indian Ocean flow in May and November. In contrast, air reaching Kenya at 400 hPa is mainly from southwest Indian Ocean in January and March, which is replaced by Saharan transport in May and November. Transport of air from Kenya is invariant, both spatially and temporally, in the tropical easterlies to the Congo Basin and Atlantic Ocean in comparison to the transport to the country. Recirculation of air has also been observed but on a limited and often local scale and not to the extent reported in southern Africa.

  1. A soil moisture climatology of Illinois

    Energy Technology Data Exchange (ETDEWEB)

    Hollinger, S.E.; Isard, S.A. (Illinois State Water Survey, Champaign, IL (United States) Univ. of Illinois, Urbana, IL (United States))

    1994-05-01

    Ten years of soil moisture measurements (biweekly from March through September and monthly during winter) within the top 1 m of soil at 17 grass-covered sites across Illinois are analyzed to provide a climatology of soil moisture for this important Midwest agricultural region. Soil moisture measurements were obtained with neutron probes that were calibrated for each site. Measurement errors are dependent upon the volumetric water content with errors less than 20 percent when soil moisture is above 0 percent of soil volume. Single point errors in moisture measurements from the top 1 m of soil range from 6 percent to 13 percent when volumetric soil moisture is 30 percent of soil volume. The average depletion in moisture between winter and summer over the 10-year period for the top 2 m of soil in Illinois was 72.3 mm. Three-quarters of this decrease occurred above 0.5 m and only 5 percent occurred between the 1.0-m and 2.0-m depths. The average moisture decrease between winter and summer during a wet year (1985) and a drought year (1988) in the top 2 m of soil was 64 percent and 204 percent of the average for the 10-year period, respectively. Seasonal means in soil moisture averaged for the state show the effects of different seasons and soil types on soil moisture. In the winter and spring a latitudinal gradient exists with the wetter soils in the southern part of the state. During summer and autumn there is a longitudinal gradient with the wetter soils in the eastern half of the state. The longitudinal gradient is closely associated with the depth of loess deposits.

  2. A Radar Climatology for Germany - a 16-year high resolution precipitation data and its possibilities

    Science.gov (United States)

    Walawender, Ewelina; Winterrath, Tanja; Brendel, Christoph; Hafer, Mario; Junghänel, Thomas; Klameth, Anna; Weigl, Elmar; Becker, Andreas

    2017-04-01

    One of the main features of heavy precipitation events is their small-scale distribution. Despite a local occurrence, these intensive rainfalls may, however, cause most serious damage and have significant impact on the whole river basin area resulting in e.g. flash floods or urban flooding. Thus, it is of great importance not only to detect the life-cycle of extreme precipitation during its occurrence but also to collect precise climatological information on such events. The German weather service (Deutscher Wetterdienst) operates a very dense network of more than 2000 weather stations collecting data on precipitation. It is however not sufficient for detecting spatially limited phenomena. Thanks to radar data, current monitoring of such events is possible. A quality control process is applied to real-time radar products, however only automatic rain gauges data can be used in the adjustment procedure. To merge both radar data and all available rain gauges data, the radar climatology dataset was established. Within the framework of a project financed by the federal agencies' strategic alliance 'Adaptation to Climate Change', 16 years (2001-2016) of radar data have been reanalyzed in order to gain a homogenous, quality-controlled, high-resolution precipitation data set suitable for analyzing extreme events in a climatological approach. Additional corrections methods (e.g. clutter, spokes and beam height correction) were defined and used for the reprocessing procedure to enhance the data quality. Although the time series is still rather short for a climatology, for the first time the data set allows an insight into e.g. the distribution, size, life cycle, and duration of extreme events that cannot be measured by point measurements alone. All radar climatology products share the same spatial and temporal coverage. The whole dataset has been produced for the area of Germany. With the relatively high spatial resolution of 1km, the data can be used as a component of wide

  3. Time resolved spectroscopic investigation of SiD2 + D2: kinetic study

    Science.gov (United States)

    Al-Rubaiey, Najem A.; Walsh, Robin

    2017-03-01

    Silylenes (silanediyls) have made an important impact on organosilicon chemistry even if it is of more recent foundation than carbenes in organic chemistry and much less complete. These species are highly reactive intermediates. They play a central role in the chemical vapour deposition (CVD) of various silicon-containing thin films which have a technological importance in microelectronics as well as in the dry etching processes of silicon wafers. Spectroscopic methods have been developed to observe these species, a necessary pre-requisite to their direct monitoring. In this work, deuterated phenylsilane precursor, PhSiD3 was chosen for SiD2 because its analogue phenylsilane, PhSiH3 proved to be a good precursor for SiH2 and the high quality decay signals observed revealed that SiD2 be readily detected from PhSiD3 and that if other decomposition pathways (e.g. PhSiD + D2) are occurring, they do not effect measurements of the rate constants for SiD2. The absorption spectrum of SiD2 formed from the flash photolysis of a mixture of PhSiD3 and SF6 at 193nm were found in the region 17384-17391 cm-1 with strong band at 17387.07 cm-1. This single rotational line of pQ1 was chosen to monitor SiD2 removal. Time-resolved studies of SiD2 have been carried out to obtain rate constants for its bimolecular reactions with D2. The reactions were studied over the pressure range 5-100 Torr (in SF6 bath gas) at four temperatures in the range 298-498K. Single decay from 10 photolysis laser shots were averaged and found to give reasonable first-order kinetics fits. Second order kinetics were obtained by pressure dependence of the pseudo first order decay constants and substance D2 pressures within experimental error. The reaction was found to be weakly pressure dependent at all temperatures, consistent with a third-body mediated association process. In addition, SiH2+ H2 reaction is approximately ca. 60% faster than SiD2+D2 reaction. Theoretical extrapolations (using Lindemann

  4. Time resolved spectroscopic investigation of SiD2 + D2: kinetic study

    Directory of Open Access Journals (Sweden)

    Al-Rubaiey Najem A.

    2017-01-01

    Full Text Available Silylenes (silanediyls have made an important impact on organosilicon chemistry even if it is of more recent foundation than carbenes in organic chemistry and much less complete. These species are highly reactive intermediates. They play a central role in the chemical vapour deposition (CVD of various silicon-containing thin films which have a technological importance in microelectronics as well as in the dry etching processes of silicon wafers. Spectroscopic methods have been developed to observe these species, a necessary pre-requisite to their direct monitoring. In this work, deuterated phenylsilane precursor, PhSiD3 was chosen for SiD2 because its analogue phenylsilane, PhSiH3 proved to be a good precursor for SiH2 and the high quality decay signals observed revealed that SiD2 be readily detected from PhSiD3 and that if other decomposition pathways (e.g. PhSiD + D2 are occurring, they do not effect measurements of the rate constants for SiD2. The absorption spectrum of SiD2 formed from the flash photolysis of a mixture of PhSiD3 and SF6 at 193nm were found in the region 17384-17391 cm-1 with strong band at 17387.07 cm-1. This single rotational line of pQ1 was chosen to monitor SiD2 removal. Time-resolved studies of SiD2 have been carried out to obtain rate constants for its bimolecular reactions with D2. The reactions were studied over the pressure range 5-100 Torr (in SF6 bath gas at four temperatures in the range 298-498K. Single decay from 10 photolysis laser shots were averaged and found to give reasonable first-order kinetics fits. Second order kinetics were obtained by pressure dependence of the pseudo first order decay constants and substance D2 pressures within experimental error. The reaction was found to be weakly pressure dependent at all temperatures, consistent with a third-body mediated association process. In addition, SiH2+ H2 reaction is approximately ca. 60% faster than SiD2+D2 reaction. Theoretical extrapolations (using

  5. A spectral climatology for atmospheric compensation of hyperspectral imagery

    Science.gov (United States)

    Powell, John H.; Resmini, Ronald G.

    2016-05-01

    Most Earth observation hyperspectral imagery (HSI) detection and identification algorithms depend critically upon a robust atmospheric compensation capability to correct for the effects of the atmosphere on the radiance signal. Atmospheric compensation methods typically perform optimally when ancillary ground truth data are available, e.g., high fidelity in situ radiometric observations or atmospheric profile measurements. When ground truth is incomplete or not available, additional assumptions must be made to perform the compensation. Meteorological climatologies are available to provide climatological norms for input into the radiative transfer models; however no such climatologies exist for empirical methods. The success of atmospheric compensation methods such as the empirical line method suggests that remotely sensed HSI scenes contain comprehensive sets of atmospheric state information within the spectral data itself. It is argued that large collections of empirically-derived atmospheric coefficients collected over a range of climatic and atmospheric conditions comprise a resource that can be applied to prospective atmospheric compensation problems. A previous study introduced a new climatological approach to atmospheric compensation in which empirically derived spectral information, rather than sensible atmospheric state variables, is the fundamental datum. The current work expands the approach across an experimental archive of 127 airborne HSI datasets spanning nine physical sites to represent varying climatological conditions. The representative atmospheric compensation coefficients are assembled in a scientific database of spectral observations and modeled data. Improvements to the modeling methods used to standardize the coefficients across varying collection and illumination geometries and the resulting comparisons of adjusted coefficients are presented. The climatological database is analyzed to show that common spectral similarity metrics can be used

  6. Ecodriver. D2.4: Plan for using and disseminating knowledge_Public

    NARCIS (Netherlands)

    Winder, A.; et al

    2016-01-01

    The full D2.4 confidential deliverable describes the ecoDriver project’s key projected results and the plans for exploiting them. This public version omits the chapters on expoitoitable results and the project partners plans for exploiting them. This is the third year version of the deliverable repo

  7. Global two-channel AVHRR aerosol climatology: effects of stratospheric aerosols and preliminary comparisons with MODIS and MISR retrievals

    Energy Technology Data Exchange (ETDEWEB)

    Geogdzhayev, Igor V. [Department of Applied Physics and Applied Mathematics, Columbia University, 2880 Broadway, New York, NY 10025 (United States); NASA Goddard Institute for Space Studies, 2880 Broadway, New York, NY 10025 (United States); Mishchenko, Michael I. [NASA Goddard Institute for Space Studies, 2880 Broadway, New York, NY 10025 (United States)]. E-mail: crmim@giss.nasa.gov; Liu Li [NASA Goddard Institute for Space Studies, 2880 Broadway, New York, NY 10025 (United States); Department of Earth and Environmental Sciences, Columbia University, 2880 Broadway, New York, NY 10025 (United States); Remer, Lorraine [NASA Goddard Space Flight Center, Code 913, Greenbelt, MD 20771 (United States)

    2004-10-15

    We present an update on the status of the global climatology of the aerosol column optical thickness and Angstrom exponent derived from channel-1 and -2 radiances of the Advanced Very High Resolution Radiometer (AVHRR) in the framework of the Global Aerosol Climatology Project (GACP). The latest version of the climatology covers the period from July 1983 to September 2001 and is based on an adjusted value of the diffuse component of the ocean reflectance as derived from extensive comparisons with ship sun-photometer data. We use the updated GACP climatology and Stratospheric Aerosol and Gas Experiment (SAGE) data to analyze how stratospheric aerosols from major volcanic eruptions can affect the GACP aerosol product. One possible retrieval strategy based on the AVHRR channel-1 and -2 data alone is to infer both the stratospheric and the tropospheric aerosol optical thickness while assuming fixed microphysical models for both aerosol components. The second approach is to use the SAGE stratospheric aerosol data in order to constrain the AVHRR retrieval algorithm. We demonstrate that the second approach yields a consistent long-term record of the tropospheric aerosol optical thickness and Angstrom exponent. Preliminary comparisons of the GACP aerosol product with MODerate resolution Imaging Spectrometer (MODIS) and Multiangle Imaging Spectro-Radiometer aerosol retrievals show reasonable agreement, the GACP global monthly optical thickness being lower than the MODIS one by approximately 0.03. Larger differences are observed on a regional scale. Comparisons of the GACP and MODIS Angstrom exponent records are less conclusive and require further analysis.

  8. D2 Lymphadenectomy in Gastric Cancer Surgery

    Institute of Scientific and Technical Information of China (English)

    Jingyu Deng; Han Liang

    2009-01-01

    Gastric cancer is one of the most common causes of cancer death worldwide. Surgery is the most widely utilized treatment for resectable gastric cancer. Evidence indicates that lymph node involvement and depth of invasion of the primary tumor are the most important prognostic factors for gastric cancer patients. Therefore, lymph node clearance is deemed a key procedure in gastric cancer surgery for the prognostic value to patients. Although the appropriate lymphadenectomy during gastrectomy for cancer still remains controversial, extended lymph node dissection (D2 lymphadenectomy) should be recommended in high volume hospitals.

  9. Generating Generalized $G_{D-2}$ solutions

    CERN Document Server

    Bretón, N; López, L A

    2008-01-01

    We show how one can systematically construct vacuum solutions to Einstein field equations with $D-2$ commuting Killing vectors in $D>4$ dimensions. The construction uses Einstein-scalar field seed solutions in 4 dimensions and is performed both for the case when all the Killing directions are spacelike, as well as when one of the Killing vectors is timelike. The later case corresponds to generalizations of stationary axially symmetric solutions to higher dimensions. Some examples representing generalizations of known higher dimensional stationary solutions are discussed in terms of their rod structure and horizon locations and deformations.

  10. Chemical climatology of the southeastern United States, 1999–2013

    Directory of Open Access Journals (Sweden)

    G. M. Hidy

    2014-06-01

    Full Text Available A series of experiments (the Southern Oxidant and Aerosol Study-SOAS took place in central Alabama in June–July 2013 as part of the broader Southern Atmosphere Study (SAS. These projects were aimed at studying oxidant photochemistry and formation and impacts of aerosols at a detailed process level in a location where high biogenic organic vapor emissions interact with anthropogenic emissions, and the atmospheric chemistry occurs in a subtropical climate in North America. The majority of the ground-based experiments were located at the Southeastern Aerosol Research and Characterization (SEARCH Centreville (CTR site near Brent, Alabama, where extensive, unique aerometric measurements of meteorology, trace gases and particles have been made from the early 1990s through 2013. The SEARCH network data permits a characterization of temporal and spatial context of the SOAS findings. The long-term measurements show that the SOAS experiments took place during the second wettest and coolest year in the 2000–2013 period, with lower than average solar radiation. The pollution levels at CTR and other SEARCH sites were the lowest since full measurements began in 1999. This dataset provides a perspective for the SOAS program in terms of long-term average chemistry (chemical climatology and short-term comparisons of summer average spatial variability across the Southeast at high temporal (hourly resolution. Changes in anthropogenic gas and particle emissions between 1999 and 2013, account for the decline in pollutant concentrations at the monitoring sites in the region. The long-term and short-term data provide an opportunity to contrast SOAS results with temporally and spatially variable conditions in support for the development of tests for the robustness of SOAS findings.

  11. Chemical climatology of the southeastern United States, 1999-2013

    Science.gov (United States)

    Hidy, G. M.; Blanchard, C. L.; Baumann, K.; Edgerton, E.; Tanenbaum, S.; Shaw, S.; Knipping, E.; Tombach, I.; Jansen, J.; Walters, J.

    2014-11-01

    A series of experiments (the Southern Oxidant and Aerosol Study - SOAS) took place in central Alabama in June-July, 2013 as part of the broader Southern Atmosphere Study (SAS). These projects were aimed at studying oxidant photochemistry and formation and impacts of aerosols at a detailed process level in a location where high biogenic organic vapor emissions interact with anthropogenic emissions, and the atmospheric chemistry occurs in a subtropical climate in North America. The majority of the ground-based experiments were located at the Southeastern Aerosol Research and Characterization (SEARCH) Centreville (CTR) site near Brent, Alabama, where extensive, unique aerometric measurements of trace gases and particles and meteorology were made beginning in the early 1990s through 2013. The SEARCH network data permits a characterization of the temporal and spatial context of the SOAS findings. Our earlier analyses of emissions and air quality trends are extended through 2013 to provide a perspective for continued decline in ambient concentrations, and the implications of these changes to regional sulfur oxide, nitrogen-ozone, and carbon chemistry. The narrative supports the SAS program in terms of long-term average chemistry (chemical climatology) and short-term comparisons of early summer average spatial variability across the southeastern US at high temporal (hourly) resolution. The long-term measurements show that the SOAS experiments took place during the second wettest and coolest year in the 2000-2013 period, with lower than average solar radiation. The pollution levels at CTR and other SEARCH sites were the lowest since full measurements began in 1999. Changes in anthropogenic gas and particle emissions between 1999 and 2013 account for the decline in pollutant concentrations at the monitoring sites in the region. The data provide an opportunity to contrast SOAS results with temporally and spatially variable conditions in support of the development of tests

  12. Eight Year Climatologies from Observational (AIRS) and Model (MERRA) Data

    Science.gov (United States)

    Hearty, Thomas; Savtchenko, Andrey; Won, Young-In; Theobalk, Mike; Vollmer, Bruce; Manning, Evan; Smith, Peter; Ostrenga, Dana; Leptoukh, Greg

    2010-01-01

    We examine climatologies derived from eight years of temperature, water vapor, cloud, and trace gas observations made by the Atmospheric Infrared Sounder (AIRS) instrument flying on the Aqua satellite and compare them to similar climatologies constructed with data from a global assimilation model, the Modern Era Retrospective-Analysis for Research and Applications (MERRA). We use the AIRS climatologies to examine anomalies and trends in the AIRS data record. Since sampling can be an issue for infrared satellites in low earth orbit, we also use the MERRA data to examine the AIRS sampling biases. By sampling the MERRA data at the AIRS space-time locations both with and without the AIRS quality control we estimate the sampling bias of the AIRS climatology and the atmospheric conditions where AIRS has a lower sampling rate. While the AIRS temperature and water vapor sampling biases are small at low latitudes, they can be more than a few degrees in temperature or 10 percent in water vapor at higher latitudes. The largest sampling biases are over desert. The AIRS and MERRA data are available from the Goddard Earth Sciences Data and Information Services Center (GES DISC). The AIRS climatologies we used are available for analysis with the GIOVANNI data exploration tool. (see, http://disc.gsfc.nasa.gov).

  13. 21 CFR 172.379 - Vitamin D2.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Vitamin D2. 172.379 Section 172.379 Food and Drugs... Dietary and Nutritional Additives § 172.379 Vitamin D2. Vitamin D2 may be used safely in foods as a... prescribed conditions: (a) Vitamin D2, also known as ergocalciferol, is the chemical...

  14. Climatological analysis of precipitation patterns over Mount Baldo (Southern Alps)

    Science.gov (United States)

    Poletti, G.; Zardi, D.; de Franceschi, M.

    2010-09-01

    The mountain range of Mount Baldo is an elongated chain in the southern Prealps. Bounded on the western side by Lake Garda, and on the eastern side by the parallel-running deep furrow of the River Adige Valley, the whole Mount Baldo range stretches in the direction southwest-northeast for about 40 km, from the southern highlands of Caprino Veronese up to the elevated saddle joining the surroundings of Rovereto (in the Adige Valley) to the plain of Nago-Torbole (northern shore of Lake Garda). Mount Baldo displays for most of its length a sharp and uninterrupted crest ridge, mostly running over 2000 m MSL. Its surface covers a variety of altitudinal ranges, from 65 m MSL at the mountain feet, along the Lake Garda shores, to 2,218 m MSL at its highest peak (Cima Valdritta). Furthermore the particular layout of being the southernmost alpine headland, projecting as a balcony over the Po Plain, makes it exposed to the climatic influence of the larger Mediterranean basin. All of these factors concurred to develop a remarkable variety of local microclimates, geographical characters and ecosystems. In particular Mount Baldo is well known for its varied flora, whence it has been named, since 16th century, Hortus Europae (Europe Garden). Precipitation is one of the key factors characterising the peculiar local climates of Mount Baldo. Various precipitation features can be produced by a variety of processes, including both orographic uplift of moist air advected by synoptic systems, and evaporation and up-slope advection of moist air from Lake Garda or from the Po Plain. Furthermore these effects may variously develop, and even combine, under different meteorological scenarios. In the present contribution the preliminary results are shown from a research work aiming at retrieving, collecting in a homogeneous dataset and analysing data from 18 weather stations disseminated on Mount Baldo, in order to produce a climatological analysis of precipitation in the area. The whole

  15. Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking.

    Science.gov (United States)

    Heinsbroek, Jasper A; Neuhofer, Daniela N; Griffin, William C; Siegel, Griffin S; Bobadilla, Ana-Clara; Kupchik, Yonatan M; Kalivas, Peter W

    2017-01-25

    Distinct populations of D1- and D2-dopamine receptor-expressing medium spiny neurons (D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes, whereas activity in D2-MSNs inhibits, motivated behaviors. We used chemogenetics to extend D1-/D2-MSN cell specific regulation to cue-reinstated cocaine seeking in a mouse model of self-administration and relapse, and found that either increasing activity in D1-MSNs or decreasing activity in D2-MSNs augmented cue-induced reinstatement. Both D1- and D2-MSNs provide substantial GABAergic innervation to the ventral pallidum, and chemogenetic inhibition of ventral pallidal neurons blocked the augmented reinstatement elicited by chemogenetic regulation of either D1- or D2-MSNs. Because D1- and D2-MSNs innervate overlapping populations of ventral pallidal neurons, we next used optogenetics to examine whether changes in synaptic plasticity in D1- versus D2-MSN GABAergic synapses in the ventral pallidum could explain the differential regulation of VP activity. In mice trained to self-administer cocaine, GABAergic LTD was abolished in D2-, but not in D1-MSN synapses. A μ opioid receptor antagonist restored GABA currents in D2-, but not D1-MSN synapses of cocaine-trained mice, indicating that increased enkephalin tone on presynaptic μ opioid receptors was responsible for occluding the LTD. These results identify a behavioral function for D1-MSN innervation of the ventral pallidum, and suggest that losing LTDGABA in D2-MSN, but not D1-MSN input to ventral pallidum may promote cue-induced reinstatement of cocaine-seeking. More than 90% of ventral striatum is composed of two cell types, those expressing dopamine D1 or D2 receptors, which exert opposing roles on motivated behavior. Both cell types send GABAergic projections to the ventral pallidum and were found to differentially promote cue-induced reinstatement of cocaine seeking via the ventral pallidum. Furthermore, after cocaine self-administration, synaptic

  16. Weighted linear regression using D2H and D2 as the independent variables

    Science.gov (United States)

    Hans T. Schreuder; Michael S. Williams

    1998-01-01

    Several error structures for weighted regression equations used for predicting volume were examined for 2 large data sets of felled and standing loblolly pine trees (Pinus taeda L.). The generally accepted model with variance of error proportional to the value of the covariate squared ( D2H = diameter squared times height or D...

  17. GLOBE backscatter - Climatologies and mission results. [Global Backscatter Experiment

    Science.gov (United States)

    Menzies, Robert T.; Post, Madison J.

    1991-01-01

    The Global Backscatter Experiment (GLOBE) goals require intensive study of the global climatology of atmospheric aerosol backscatter at IR wavelengths. Airborne and ground-based lidars have been developed to measure atmospheric backscatter profiles at CO2 laser wavelengths. Descriptions of the calibration techniques and selected measurement results are presented.

  18. Climatology and Landfall of Tropical Cyclones in the South- West ...

    African Journals Online (AJOL)

    Mozambique; 2University of Gothenburg, Department of Earth Sciences, Oceanography, Box 460, SE-405. 30 Gothenburg ... La Reunion – Regional Specialised Meteorological Centre. During the ..... higher mean genesis temperature than climatology. SSTs. ..... Australian Meteorological Society, 16, 135-137. Klinman M.G ...

  19. A climatological description of the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Hunter, C.H.

    1990-05-22

    This report provides a general climatological description of the Savannah River Site. The description provides both regional and local scale climatology. The regional climatology includes a general regional climatic description and presents information on occurrence frequencies of the severe meteorological phenomena that are important considerations in the design and siting of a facility. These phenomena include tornadoes, thunderstorms, hurricanes, and ice/snow storms. Occurrence probabilities given for extreme tornado and non-tornado winds are based on previous site specific studies. Local climatological conditions that are significant with respect to the impact of facility operations on the environment are described using on-site or near-site meteorological data. Summaries of wind speed, wind direction, and atmospheric stability are primarily based on the most recently generated five-year set of data collected from the onsite meteorological tower network (1982--86). Temperature, humidity, and precipitation summaries include data from SRL's standard meteorological instrument shelter and the Augusta National Weather Service office at Bush Field through 1986. A brief description of the onsite meteorological monitoring program is also provided. 24 refs., 15 figs., 22 tabs.

  20. Dopamine D2 receptors and striatopallidal transmission in addiction and obesity.

    Science.gov (United States)

    Kenny, Paul J; Voren, George; Johnson, Paul M

    2013-08-01

    Drug addiction and obesity share the core feature that those afflicted by the disorders express a desire to limit drug or food consumption yet persist despite negative consequences. Emerging evidence suggests that the compulsivity that defines these disorders may arise, to some degree at least, from common underlying neurobiological mechanisms. In particular, both disorders are associated with diminished striatal dopamine D2 receptor (D2R) availability, likely reflecting their decreased maturation and surface expression. In striatum, D2Rs are expressed by approximately half of the principal medium spiny projection neurons (MSNs), the striatopallidal neurons of the so-called 'indirect' pathway. D2Rs are also expressed presynaptically on dopamine terminals and on cholinergic interneurons. This heterogeneity of D2R expression has hindered attempts, largely using traditional pharmacological approaches, to understand their contribution to compulsive drug or food intake. The emergence of genetic technologies to target discrete populations of neurons, coupled to optogenetic and chemicogenetic tools to manipulate their activity, have provided a means to dissect striatopallidal and cholinergic contributions to compulsivity. Here, we review recent evidence supporting an important role for striatal D2R signaling in compulsive drug use and food intake. We pay particular attention to striatopallidal projection neurons and their role in compulsive responding for food and drugs. Finally, we identify opportunities for future obesity research using known mechanisms of addiction as a heuristic, and leveraging new tools to manipulate activity of specific populations of striatal neurons to understand their contributions to addiction and obesity.

  1. A regional climatology of the Humboldt Current System

    Science.gov (United States)

    Grados Quispe, M.; Chaigneau, A.; Blanco, J.; Vasquez, L.; Dominguez, N.

    2009-12-01

    A 3-dimensional, high-resolution, regional climatology of the Humboldt Current System (HCS) north of 25°S is presented. The methodology is based on a four-dimensional ocean interpolation scheme using locally weighted least square fitting, as developed by Dunn and Ridgway [2001] and Ridgway et al. [2002] in the Australian Seas. The method is applied to all the available historical profiles from the National Oceanographic Data Center [WOD05, Boyer et al., 2006], ARGO buoy profiles [http://www.argo.ucsd.edu] for 2000-2007 and historical in situ long-term information from the Peruvian Marine Research Institute (IMARPE) and Fisheries Development Institute (IFOP) for the period 1960-2008. The regional climatology, which extends from the equator to 25°S and from the coast to 8° offshore with a resolution of 0.1°x0.1°, is thus constructed from more than 70 000 temperature profiles, 38 000 salinity profiles and 43 000 oxygen profiles to form a seasonal climatology of temperature and salinity along Peru and northern Chile. The resulting maps depict interesting small-scales coastal properties such as clear distinct upwelling centers and frontal zones. Geostrophic currents relative to 500 m depth are also computed from the density field, highlighting new circulation features. This study provides a contemporaneous view of the circulation and the water masses characteristics in the Humboldt Current System at seasonal scales. This regional climatology represents coastal boundary features (upwelling cells, frontal regions) better than other climatologies. In view of on-going international research efforts to understand the coastal upwelling and coastal currents in the southern ocean off Peru, the main characteristics of the upwelling cell, currents and coastal winds variability of the Pisco (13°S)-San Juan (15°S) region are presented. This improved gridded product is expected to be used for initializing and validating high resolution regional numerical models.

  2. 21 CFR 582.5950 - Vitamin D2.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Vitamin D2. 582.5950 Section 582.5950 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS... 1 § 582.5950 Vitamin D2. (a) Product. Vitamin D2. (b) Conditions of use. This substance is...

  3. Evaluation of low-dose limits in 3D-2D rigid registration for surgical guidance

    Science.gov (United States)

    Uneri, A.; Wang, A. S.; Otake, Y.; Kleinszig, G.; Vogt, S.; Khanna, A. J.; Gallia, G. L.; Gokaslan, Z. L.; Siewerdsen, J. H.

    2014-09-01

    An algorithm for intensity-based 3D-2D registration of CT and C-arm fluoroscopy is evaluated for use in surgical guidance, specifically considering the low-dose limits of the fluoroscopic x-ray projections. The registration method is based on a framework using the covariance matrix adaptation evolution strategy (CMA-ES) to identify the 3D patient pose that maximizes the gradient information similarity metric. Registration performance was evaluated in an anthropomorphic head phantom emulating intracranial neurosurgery, using target registration error (TRE) to characterize accuracy and robustness in terms of 95% confidence upper bound in comparison to that of an infrared surgical tracking system. Three clinical scenarios were considered: (1) single-view image + guidance, wherein a single x-ray projection is used for visualization and 3D-2D guidance; (2) dual-view image + guidance, wherein one projection is acquired for visualization, combined with a second (lower-dose) projection acquired at a different C-arm angle for 3D-2D guidance; and (3) dual-view guidance, wherein both projections are acquired at low dose for the purpose of 3D-2D guidance alone (not visualization). In each case, registration accuracy was evaluated as a function of the entrance surface dose associated with the projection view(s). Results indicate that images acquired at a dose as low as 4 μGy (approximately one-tenth the dose of a typical fluoroscopic frame) were sufficient to provide TRE comparable or superior to that of conventional surgical tracking, allowing 3D-2D guidance at a level of dose that is at most 10% greater than conventional fluoroscopy (scenario #2) and potentially reducing the dose to approximately 20% of the level in a conventional fluoroscopically guided procedure (scenario #3).

  4. Underground design Laxemar, Layout D2

    Energy Technology Data Exchange (ETDEWEB)

    2009-11-15

    Laxemar candidate area is located in the province of Smaaland, some 320 km south of Stockholm. The area is located close to the shoreline of the Baltic Sea and is within the municipality of Oskarshamn, and immediately west of the Oskarshamn nuclear power plant and the Central interim storage facility for spent fuel (Clab). The easternmost part (Simpevarp subarea) includes the Simpevarp peninsula, which hosts the power plants and the Clab facility. The island of Aespoe, containing the Aespoe Hard Rock Laboratory is located some three kilometres northeast of the central parts of Laxemar. The Laxemar subarea covers some 12.5 km2, compared with the Simepvarp subarea, which is approximately 6.6 km2. The Laxemar candidate area has been investigated in stages, referred to as the initial site investigations (ISI) and the complete site investigations (CSI). These investigations commenced in 2002 and were completed in 2008. During the site investigations, several studies and design steps (D0, D1 and D2) were carried out to ensure that sufficient space was available for the 6,000-canister layout within the target volume at a depth of approximately 500 m. The findings from design Step D2 for the underground facilities including the access ramp, shafts, rock caverns in a Central Area, transport tunnels, and deposition tunnels and deposition holes are contained in this report. The layout for these underground excavations at the deposition horizon requires an area of 5.7 km2, and the total rock volume to be excavated is 3,008 x 103 m3 using a total tunnel length of approximately 115 km. The behaviour of the underground openings associated with this layout is expected to be similar to the behaviour of other underground openings in the Scandinavian shield at similar depths. The dominant mode of instability is expected to be structurally controlled wedge failure. Stability of the openings will be achieved with traditional underground rock support and by orienting the openings

  5. Thermal behavior of TAXN and TCDXM D2 collimator mask, Finite element studies

    CERN Document Server

    Sklariks, Stepans

    2015-01-01

    The objective of this project was to perform thermal loading simulations of TCDXM (D2 collimator mask) and TAXN so as to allow the preliminary evaluation of the suitability of the given parts for the upcoming high luminosity upgrade that is to be performed in LHC in the nearest future.

  6. Analysis list: Nr1d2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Nr1d2 Liver + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Nr1d2.1.tsv... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Nr1d2.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Nr1d...2.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Nr1d2.Liver.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Liver.gml ...

  7. RADAR CLIMATOLOGY OF HAIL IN THE APUSENI MOUNTAINS

    Directory of Open Access Journals (Sweden)

    N. MAIER

    2011-03-01

    Full Text Available Radar Climatology of hail in the Apuseni Mountains A newmethod for the assessment of large areas with frequent occurrence of hail in a finespatial resolution and its application for the Apuseni Mountains and their adjacentareas is presented. Due to the fine tempo-spatial resolution of the radar detection,the creation of radar climatology of the areas where the hail production conditionsare determined is imposed. With the help of two Doppler radars at Oradea andBobohalma, the area of interest is examined and spatial maps of the relativefrequency of hail contained in the clouds are made. Composite maps are made (bysuperimposing the two Doppler radar images from Oradea and Bobohalma of theareas in which clouds with hail of different sizes occur.

  8. Climatologies at high resolution for the Earth land surface areas

    CERN Document Server

    Karger, Dirk Nikolaus; Böhner, Jürgen; Kawohl, Tobias; Kreft, Holger; Soria-Auza, Rodrigo Wilber; Zimmermann, Niklaus; Linder, H Peter; Kessler, Michael

    2016-01-01

    High resolution information of climatic conditions is essential to many application in environmental sciences. Here we present the CHELSA algorithm to downscale temperature and precipitation estimates from the European Centre for Medium-Range Weather Forecast (ECMWF) climatic reanalysis interim (ERA-Interim) to a high resolution of 30 arc sec. The algorithm for temperature is based on a statistical downscaling of atmospheric temperature from the ERA-Interim climatic reanalysis. The precipitation algorithm incorporates orographic predictors such as wind fields, valley exposition, and boundary layer height, and a bias correction using Global Precipitation Climatology Center (GPCC) gridded and Global Historical Climate Network (GHCN) station data. The resulting data consist of a monthly temperature and precipitation climatology for the years 1979-2013. We present a comparison of data derived from the CHELSA algorithm with two other high resolution gridded products with overlapping temporal resolution (Tropical R...

  9. Towards a generalization procedure for WRF mesoscale wind climatologies

    DEFF Research Database (Denmark)

    Hahmann, Andrea N.; Casso, P.; Campmany, E.

    We present a method for generalizing wind climatologies generated from mesoscale model output (e.g. the Weather, Research and Forecasting (WRF) model.) The generalization procedure is based on Wind Atlas framework of WAsP and KAMM/WAsP, and been extensively in wind resources assessment in DTU Wind...... generalized wind climatologies estimated by the microscale model WAsP and the methodology presented here. For the Danish wind measurements the mean absolute error in the ‘raw’ wind speeds is 9.2%, while the mean absolute error in the generalized wind speeds is 4.1%. The generalization procedure has been...... installed and automated in the Vortex downscaling chain for the MAPS calculation, which are computed at 3 km horizontal resolution grid. For the MAPS-derived wind speeds the mean absolute error in the ‘raw’ wind speeds is 17.3%, while the mean absolute error in the generalized winds is 10.7%....

  10. Climatology of surface ultraviolet-radiation in Valparaiso, Chile

    Energy Technology Data Exchange (ETDEWEB)

    Cordero, Raul R. [Universidad Tecnica Federico Santa Maria, Ave. Espana 1680, Valparaiso (Chile) and Escuela Superior Politecnica del Litoral, Km. 30, 5 Via Perimetral, Guayaquil (Ecuador)]. E-mail: raul.cordero@usm.cl; Roth, Pedro [Universidad Tecnica Federico Santa Maria, Ave. Espana 1680, Valparaiso (Chile); Georgiev, Aleksandar [Technical University of Sofia, 4023 Plovdiv (Bulgaria); Silva, Luis da [Universidad Tecnica Federico Santa Maria, Ave. Espana 1680, Valparaiso (Chile)

    2005-11-15

    Despite the lack of long-term records, it is possible to describe many of the short term characteristics, dependencies and climatology of surface UV irradiance. This paper describes the climatology of on ground UV irradiance at Valparaiso (33.05 deg. S, 71.63 deg. W, sea level), Chile. The dependence of UV-B irradiance on ozone and on other climate variables is discussed with reference to our observations conducted during the last four years. Special attention was paid to detect 'ozone events' by surface UV irradiance measurements. By analyzing time series of the UV-B/UV-A ratio, we suppressed the cloud variability effect and detected events that implied ozone column changes of about 15%. According to our measurements, during the last four years, the ozone column over Valparaiso was not affected negatively by the Antarctic ozone hole phenomenon.

  11. Clear sky atmosphere at cm-wavelengths from climatology data

    CERN Document Server

    Lew, Bartosz

    2015-01-01

    We utilise ground-based, balloon-born and satellite climatology data to reconstruct site and season-dependent vertical profiles of precipitable water vapour (PWV). We use these profiles to numerically solve radiative transfer through the atmosphere, and derive atmospheric brightness temperature ($T_{\\rm atm}$) and optical depth ($\\tau$) at the centimetre wavelengths. We validate the reconstruction by comparing the model column PWV, with photometric measurements of PWV, performed in the clear sky conditions towards the Sun. Based on the measurements, we devise a selection criteria to filter the climatology data to match the PWV levels to the expectations of the clear sky conditions. We apply the reconstruction to the location of the Polish 32-metre radio telescope, and characterise $T_{\\rm atm}$ and $\\tau$ year-round, at selected frequencies. We also derive the zenith distance dependence for these parameters, and discuss shortcomings of using planar, single-layer, and optically thin atmospheric model approxima...

  12. Evaluations of SST Climatologies in the Tropical Pacific Ocean

    Science.gov (United States)

    2009-02-27

    boundaries Casey and Cornillon, 1999]. An observation-based clima - r 1 -ru 1 r.u- • . .r e...along with SSTs from AVHRR satellite retrievals. The NOAA SST product was built from two intermediate climatologies: a 2° SST clima - tology developed...2D-Var data sets, depending on the period considered. Thus, ECMWF clima - tologies examined here are the analyses of SST observations prescribed as

  13. Ozonesonde climatology between 1995 and 2009: description, evaluation and applications

    Directory of Open Access Journals (Sweden)

    S. Tilmes

    2011-10-01

    Full Text Available An ozone climatology based on ozone soundings for the last 15 years has been constructed for model evaluation and comparisons to other observations. Vertical ozone profiles for 41 stations around the globe have been compiled and averaged for the years 1980–1994 and 1995–2009. The climatology provides information about the median and the width of the ozone probability distribution function, as well as interannual variability of ozone between 1995 and 2009, in pressure and tropopause-referenced altitudes. In addition to single stations, regional aggregates are presented, combining stations with similar ozone characteristics. The Hellinger distance is introduced as a new diagnostic to compare the variability of ozone distributions within each region and used for model evaluation purposes. This measure compares not only the mean, but also the shape of distributions. The representativeness of regional aggregates is discussed using independent observations from surface stations and MOZAIC aircraft data. Ozone from all of these data sets show an excellent agreement within the range of the interannual variability, especially if a sufficient number of measurements are available, as is the case for West Europe. Within the climatology, a significant longitudinal variability of ozone in the troposphere and lower stratosphere in the northern mid- and high latitudes is found. The climatology is used to evaluate results from two model intercomparison activities, HTAP for the troposphere and CCMVal2 for the tropopause region and the stratosphere. HTAP ozone is in good agreement with observations in the troposphere within their range of uncertainty, but ozone peaks too early in the Northern Hemisphere spring. The strong gradients of ozone around the tropopause are less well captured by many models. Lower stratospheric ozone is overestimated for all regions by the multi-model mean of CCMVal2 models. Individual models also show major shortcomings in

  14. Seasonal streamflow forecasting by conditioning climatology with precipitation indices

    Science.gov (United States)

    Crochemore, Louise; Ramos, Maria-Helena; Pappenberger, Florian; Perrin, Charles

    2017-03-01

    Many fields, such as drought-risk assessment or reservoir management, can benefit from long-range streamflow forecasts. Climatology has long been used in long-range streamflow forecasting. Conditioning methods have been proposed to select or weight relevant historical time series from climatology. They are often based on general circulation model (GCM) outputs that are specific to the forecast date due to the initialisation of GCMs on current conditions. This study investigates the impact of conditioning methods on the performance of seasonal streamflow forecasts. Four conditioning statistics based on seasonal forecasts of cumulative precipitation and the standardised precipitation index were used to select relevant traces within historical streamflows and precipitation respectively. This resulted in eight conditioned streamflow forecast scenarios. These scenarios were compared to the climatology of historical streamflows, the ensemble streamflow prediction approach and the streamflow forecasts obtained from ECMWF System 4 precipitation forecasts. The impact of conditioning was assessed in terms of forecast sharpness (spread), reliability, overall performance and low-flow event detection. Results showed that conditioning past observations on seasonal precipitation indices generally improves forecast sharpness, but may reduce reliability, with respect to climatology. Conversely, conditioned ensembles were more reliable but less sharp than streamflow forecasts derived from System 4 precipitation. Forecast attributes from conditioned and unconditioned ensembles are illustrated for a case of drought-risk forecasting: the 2003 drought in France. In the case of low-flow forecasting, conditioning results in ensembles that can better assess weekly deficit volumes and durations over a wider range of lead times.

  15. Dynamic quantum molecular sieving separation of D2 from H2-D2 mixture with nanoporous materials.

    Science.gov (United States)

    Niimura, Subaru; Fujimori, Toshihiko; Minami, Daiki; Hattori, Yoshiyuki; Abrams, Lloyd; Corbin, Dave; Hata, Kenji; Kaneko, Katsumi

    2012-11-14

    Quantum molecular sieving separability of D(2) from an H(2)-D(2) mixture was measured at 77 K for activated carbon fiber, carbon molecular sieve, zeolite and single wall carbon nanotube using a flow method. The amount of adsorbed D(2) was evidently larger than H(2) for all samples. The maximum adsorption ratio difference between D(2) and H(2) was 40% for zeolite (MS13X), yielding a selectivity for D(2) with respect to H(2) of 3.05.

  16. Hanford Site climatological data summary 1995 with historical data

    Energy Technology Data Exchange (ETDEWEB)

    Hoitink, D.J.; Burk, K.W.

    1996-05-01

    This document presents the climatological data measured at the US Department of Energy`s Hanford Site for calendar year 1995. Pacific Northwest National Laboratory operates the Hanford Meteorology Station and the Hanford Meteorological Monitoring Network from which these data were collected. The information contained herein includes updated historical climatologies for temperature, precipitation, normal and extreme values of temperature and precipitation, and other miscellaneous meteorological parameters. Further, the data are adjunct to and update Hoitink and Burk (1994, 1995); however, Appendix B--Wind Climatology (1994) is excluded. 1995 was warmer than normal, averaging 54.7 F, 1.4 F above normal (53.3 F). For the 12-month period, 8 months were warmer than normal, and 4 were cooler than normal. 1995 was the wettest year on record. Precipitation totaled 12.31 in., 197% of normal (6.26 in.); snowfall totaled 7.7 in., compared to the normal of 13.8 in. The average wind speed during 1995 was 7.8 mph, 0.1 mph above normal (7.7 mph). The peak gust during the year was 61 mph from the south-southwest on December 12. There were 27 days with peak gusts {ge} 40 mph, compared to a yearly average of 26.

  17. Simulated CONUS Flash Flood Climatologies from Distributed Hydrologic Models

    Science.gov (United States)

    Flamig, Z.; Gourley, J. J.; Vergara, H. J.; Kirstetter, P. E.; Hong, Y.

    2016-12-01

    This study will describe a CONUS flash flood climatology created over the period from 2002 through 2011. The MRMS reanalysis precipitation dataset was used as forcing into the Ensemble Framework For Flash Flood Forecasting (EF5). This high resolution 1-sq km 5-minute dataset is ideal for simulating flash floods with a distributed hydrologic model. EF5 features multiple water balance components including SAC-SMA, CREST, and a hydrophobic model all coupled with kinematic wave routing. The EF5/SAC-SMA and EF5/CREST water balance schemes were used for the creation of dual flash flood climatologies based on the differing water balance principles. For the period from 2002 through 2011 the daily maximum streamflow, unit streamflow, and time of peak streamflow was stored along with the minimum soil moisture. These variables are used to describe the states of the soils right before a flash flood event and the peak streamflow that was simulated during the flash flood event. The results will be shown, compared and contrasted. The resulting model simulations will be verified on basins less than 1,000-sq km with USGS gauges to ensure the distributed hydrologic models are reliable. The results will also be compared spatially to Storm Data flash flood event observations to judge the degree of agreement between the simulated climatologies and observations.

  18. The SHADOZ Data Base: History, Archive Web Guide, and Sample Climatologies

    Science.gov (United States)

    White, J. C.; Thompson, A. M.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    SHADOZ (Southern Hemisphere Additional Ozonesonde) is a project to augment and archive ozonesonde data from ten tropical and subtropical ozone stations. Started in 1998 by NASA's Goddard Space Flight Center and other US and international co-investigators, SHADOZ is an important tool for tropospheric ozone research in the equatorial region. The rationale for SHADOZ is to: (1) validate and improve remote sensing techniques (e.g., the Total Ozone Mapping Spectrometer (TOMS) satellite) for estimating tropical ozone, (2) contribute to climatology and trend analyses of tropical ozone and (3) provide research topics to scientists and educate students, especially in participating countries. SHADOZ is envisioned as a data service to the global scientific community by providing a central public archive location via the internet: http://code9l6.gsfc.nasa.gov/Data_services/shadoz. While the SHADOZ website maintains a standard data format for the archive, it also informs the data users on the differing stations' preparation techniques and data treatment. The presentation navigates through the SHADOZ website to access each station's sounding data and summarize each station's characteristics. Since the start of the project in 1998, the SHADOZ archive has accumulated over 600 ozonesonde profiles and received over 30,000 outside data requests. Data also includes launches from various SHADOZ supported field campaigns, such as, the Indian Ocean Experiment (INDOEX), Sounding of Ozone and Water in the Equatorial Region (SOWER) and Aerosols99 Atlantic Cruise. Using data from the archive, sample climatologies and profiles from selected stations and campaigns will be shown.

  19. Diva software, a tool for European regional seas and Ocean climatologies production

    Science.gov (United States)

    Ouberdous, M.; Troupin, C.; Barth, A.; Alvera-Azcàrate, A.; Beckers, J.-M.

    2012-04-01

    Diva (Data-Interpolating Variational Analysis) is a software based on a method designed to perform data-gridding (or analysis) tasks, with the assets of taking into account the intrinsic nature of oceanographic data, i.e., the uncertainty on the in situ measurements and the anisotropy due to advection and irregular coastlines and topography. The Variational Inverse Method (VIM, Brasseur et al., 1996) implemented in Diva consists in minimizing a variational principle which accounts for the differences between the observations and the reconstructed field, the influence of the gradients and variability of the reconstructed field. The resolution of the numerical problem is based on finite-element method, which allows a great numerical efficiency and the consideration of complicated contours. Along with the analysis, Diva provides also error fields (Brankart and Brasseur, 1998; Rixen et al., 2000) based on the data coverage and noise. Diva is used for the production of climatologies in the pan-European network SeaDataNet. SeaDataNet is connecting the existing marine data centres of more than 30 countries and set up a data management infrastructure consisting of a standardized distributed system. The consortium has elaborated integrated products, using common procedures and methods. Among these, it uses the Diva software as reference tool for climatologies computation for various European regional seas, the Atlantic and the global ocean. During the first phase of the SeaDataNet project, a number of additional tools were developed to make easier the climatologies production for the users. Among these tools: the advection constraint during the field reconstruction through the specification of a velocity field on a regular grid, forcing the analysis to align with the velocity vectors; the Generalized Cross Validation for the determination of analysis parameters (signal-to-noise ratio); the creation of contours at selected depths; the detection of possible outliers; the

  20. Effect of age on extrastriatal dopamine D2 receptor availability

    Energy Technology Data Exchange (ETDEWEB)

    Wang, G.J.; Volkow, N.D.; Fowler, J.S. [Brookhaven National Lab., Upton, NY (United States)]|[SUNY, Stony Brook, NY (United States)

    1996-05-01

    It is known that dopamine (DA) D2 receptor availability in basal ganglia decreases with age. This study was done to assess the effects of age on extrastriatal DA D2 receptors. DA D2 receptor availability was evaluated in 42 healthy male subjects (age mean 41 {plus_minus} 16, range 21 -86 year old) using positron emission tomography (PET) and [C-11]raclopride. DA D2 receptor availability was measured using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that in the cerebellum which is a function of B{sub max.}/K{sub d}. Pearson product-moment correlation was used to evaluate the correlation between age and D2 receptor availability. DA D2 receptor availability in putamen (r {le} 0.0001), caudate (r {le} 0.0002), thalamus (r {le} 0.03), and temporal insula (r {le} 0.01) were significantly correlated with age. The decrements in D2 receptors with age were lower in extrastriatal than in striatal regions and corresponded to a decrease of 4.7% per decade in caudate, 6.2% in putamen, 2.1% in thalamus and 2.5% in temporal insula. This study documents age related decrement of DA D2 receptor availability in striatal and extrastriatal regions.

  1. Energy Efficiency of D2D Multi-User Cooperation.

    Science.gov (United States)

    Zhang, Zufan; Wang, Lu; Zhang, Jie

    2017-03-28

    The Device-to-Device (D2D) communication system is an important part of heterogeneous networks. It has great potential to improve spectrum efficiency, throughput and energy efficiency cooperation of multiple D2D users with the advantage of direct communication. When cooperating, D2D users expend extraordinary energy to relay data to other D2D users. Hence, the remaining energy of D2D users determines the life of the system. This paper proposes a cooperation scheme for multiple D2D users who reuse the orthogonal spectrum and are interested in the same data by aiming to solve the energy problem of D2D users. Considering both energy availability and the Signal to Noise Ratio (SNR) of each D2D user, the Kuhn-Munkres algorithm is introduced in the cooperation scheme to solve relay selection problems. Thus, the cooperation issue is transformed into a maximum weighted matching (MWM) problem. In order to enhance energy efficiency without the deterioration of Quality of Service (QoS), the link outage probability is derived according to the Shannon Equation by considering the data rate and delay. The simulation studies the relationships among the number of cooperative users, the length of shared data, the number of data packets and energy efficiency.

  2. Hanford Site climatological data summary 1999 with historical data

    Energy Technology Data Exchange (ETDEWEB)

    DJ Hoitink; KW Burk; JV Ramsdell

    2000-05-11

    This document presents the climatological data measured at the US Department of Energy's Hanford Site for calendar year 1999. Pacific Northwest National Laboratory operates the Hanford Meteorology Station and the Hanford Meteorological Monitoring Network from which these data were collected. The information contained herein includes updated historical climatologies for temperature, precipitation, normal and extreme values of temperature and precipitation, and other miscellaneous meteorological parameters. Further, the data are adjunct to and update Hoitink et al. (1999), and Hoitink and Burk (1994, 1995, 1996, 1997, 1998); however, Appendix B-Wind Climatology (1994) is excluded. 1999 was warmer than normal at the Hanford Meteorology Station with an average temperature of 54.4 F, 1.1 F above normal (53.3 F). The hottest temperature was 105 F on July 28, while the coldest was 18 F on January 3. The maximum temperature of 64 F on August 30 was the lowest maximum temperature ever recorded in August, while the maximum temperature of 76 F on November 13 was the highest maximum temperature ever recorded in November. For the 12-month period, 6 months were warmer than normal and 6 were cooler than normal. 1999 was the fourth driest year on record. Precipitation totaled 3.75 inches, 60% of normal (6.26 inches); snowfall totaled 0.6 inch, the least calendar year snowfall on record (compared to the normal of 13.8 inches). 1999 was the windiest year on record with an average wind speed of 8.8 mph, 1.1 mph above normal (7.7 mph). There were 48 days with peak gust {ge} 40 mph, compared to a yearly average of 26 mph. The peak gust during the year was 65 mph on February 6. The heating-degree days for 1998--1999 were 4,802 (8% below the 5,231 normal). Cooling-degree days for 1999 were 891 (10% below the 994 normal).

  3. A simplified approach for generating GNSS radio occultation refractivity climatologies

    Directory of Open Access Journals (Sweden)

    H. Gleisner

    2012-07-01

    Full Text Available The possibility of simplifying the retrieval scheme required to produce GNSS radio occultation refractivity climatologies is investigated. In a new, simplified retrieval approach, the main statistical analysis is performed in bending angle space and an estimate of the average bending angle profile is then propagated through an Abel transform. The average is composed of means and medians of ionospheric corrected bending angles up to 80 km. Above that, the observed profile is exponentially extrapolated to infinity using a fixed a priori scale height. The new approach circumvents the need to introduce a "statistical optimization" processing step in which individual bending-angle profiles are merged with a priori data, often taken from a climatology. This processing step can be complex, difficult to interpret, and is generally recognized as a potential source of structural uncertainty. The new scheme is compared with the more conventional approach of averaging individual refractivity profiles, produced with the implementation of statistical optimization used in the EUMETSAT Radio Occultation Meteorology Satellite Application Facility (ROM SAF operational processing. It is shown that the two GNSS radio occultation climatologies agree to within 0.1% from 5 km up to 35–40 km, for the three months January, February, and March 2011. During this time period, the new approach also produces slightly better agreement with ECMWF analyses between 40–50 km, which is encouraging. The possible limitations of the new approach caused by mean residual ionospheric errors and low observation numbers are discussed briefly, and areas for future work are suggested.

  4. M-theory solutions invariant under D(2,1; γ) + D(2,1;γ)

    Energy Technology Data Exchange (ETDEWEB)

    Bachas, C. [Laboratoire de Physique Theorique de l' Ecole Normale Superieure Unite mixte (UMR 8549) du CNRS et de l' ENS, Paris (France); D' Hoker, E. [Department of Physics and Astronomy, University of California, Los Angeles, CA (United States); Estes, J. [Blackett Laboratory, Imperial College, London (United Kingdom); Krym, D. [Physics Department, New York City College of Technology, The City University of New York, Brooklyn, NY (United States)

    2014-03-06

    We simplify and extend the construction of half-BPS solutions to 11-dimensional supergravity, with isometry superalgebra D(2,1;γ) + D(2,1;γ). Their space-time has the form AdS{sub 3} x S{sup 3} x S{sup 3} warped over a Riemann surface Σ. It describes near-horizon geometries of M2 branes ending on, or intersecting with, M5 branes along a common string. The general solution to the BPS equations is specified by a reduced set of data (γ, h, G), where γ is the real parameter of the isometry superalgebra, and h and G are functions on Σ whose differential equations and regularity conditions depend only on the sign of γ. The magnitude of γ enters only through the map of h,G onto the supergravity fields, thereby promoting all solutions into families parametrized by vertical stroke γ vertical stroke. By analyzing the regularity conditions for the supergravity fields, we prove two general theorems: (i) that the only solution with a 2-dimensional CFT dual is AdS{sub 3} x S{sup 3} x S{sup 3} x R {sup 2}, modulo discrete identifications of the flat R {sup 2}, and (ii) that solutions with γ < 0 cannot have more than one asymptotic higher-dimensional AdS region. We classify the allowed singularities of h and G near the boundary of Σ, and identify four local solutions: asymptotic AdS{sub 4}/Z{sub 2} or AdS{sub 7}' regions; highly-curved M5-branes; and a coordinate singularity called the ''cap''. By putting these ''Lego'' pieces together we recover all known global regular solutions with the above symmetry, including the self-dual strings on M5 for γ <0, and the Janus solution for γ > 0, but now promoted to families parametrized by vertical stroke γ vertical stroke. We also construct exactly new regular solutions which are asymptotic to AdS{sub 4}/Z{sub 2} for γ < 0, and conjecture that they are a different superconformal limit of the self-dual string. Finally, we construct exactly γ > 0 solutions with highly curved M5

  5. An Oceanographic and Climatological Atlas of Bristol Bay

    Science.gov (United States)

    1987-10-01

    Report No. C_-_1_8 AN OCEANOGRAPHIC AND CLIMATOLOGICAL " ATLAS OF BRISTOL BAY JAMES L. WIFE LYNN D. LESLIE JOSEPH C. LABELLE Arctic Environmental...Performing Organization Report No. 7. Author(s) James L. Wise, Lynn D. Leslie , and Joseph C. LaBelle R&DC 16/87 9. Performing Organization Name and...experience. 39 Coastal Sectors for Storm Surge Forecasting 170 1650 160~ 155’ Cape Romanzof Hooper Bay Bethel IISLAND I SLAND Ki n k 1 un a aSETO I~Cp

  6. CLIMATOLOGICAL DIAGNOSIS OF WINTER TEMPERATURE VARIATIONS IN GUANGDONG

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Using the monthly mean and minimum temperature data of the 36 observation stations in Guangdong, the climatological features of the temperatures have been analyzed, including characteristics of trends, abrupt changes and periods. And the possible affecting factors on the winter warming in Guangdong have been discussed. The results show that the winter temperatures, particularly the monthly mean minimum temperatures in Guangdong, have a warming trend. The rise of the winter minimum temperatures in Guangdong began in the second half of 1960's and the warming was more evident since the 1980's.

  7. D2-40/podoplanin expression in the human placenta.

    Science.gov (United States)

    Wang, Y; Sun, J; Gu, Y; Zhao, S; Groome, L J; Alexander, J S

    2011-01-01

    Placental tissue expresses many lymphatic markers. The current study was undertaken to examine if D2-40/podoplanin, a lymphatic endothelial marker, was expressed in the human placenta, and how it is altered developmentally and pathologically. We examined D2-40/podoplanin and VEGFR-3 expressions in placentas from normotensive pregnancies at different gestational ages and in placentas from women with clinically defined preeclampsia. D2-40 expression in systemic lymphatic vessel endothelium served as a positive control. Protein expression for D2-40, VEGFR-3, and β-actin was determined by Western blot in placentas from normotensive (n = 6) and preeclamptic (n = 5) pregnancies. Our results show that D2-40/podoplanin was strongly expressed in the placenta, mainly as a network plexus pattern in the villous stroma throughout gestation. CD31 was limited to villous core fetal vessel endothelium and VEGFR-3 was found in both villous core fetal vessel endothelium and trophoblasts. D2-40/podoplanin expression was significantly decreased, and VEGFR-3 significantly increased in preeclamptic placental tissues compared to normotensive placental controls. Placental villous stroma is a reticular-like structure, and the localization of D2-40 to the stroma suggests that a lymphatic-like conductive network may exist in the human placenta. D2-40/podoplanin is an O-linked sialoglycoprotein. Although little is known regarding biological functions of sialylated glycoproteins within the placenta, placental D2-40/podoplanin may support fetal vessel angiogenesis during placenta development and reduced D2-40/podoplanin expression in preeclamptic placenta may contribute to altered interstitial fluid homeostasis and impaired angiogenesis in this pregnancy disorder.

  8. 生椎茸中のプレビタミンD_2およびビタミンD_2の同定

    OpenAIRE

    高村, 一知; 星野, 浩子; 叶多, 謙蔵; タカムラ, カズノリ; ホシノ, ヒロコ; カノウタ, ケンゾウ; Kazunori, Takamura; HIROKO, HOSHINO; KENZO, KANOHTA

    1993-01-01

    Pre-vitamin D_2(pre-D_2)and vitamin D_2(D_2)in raw shiitake mushroom were identified by liquid chromatography-mass spectrometry (LC-MS) with modified plasmaspray. 1. Pre-D_2 and D_2 in raw shiitake mushroom were separated by LC. 2. Pre-D_2 was confirmed parent ion(m/z 397 [M+H]^+)to scan number 259 of total ion chromatogram. 3. D_2 was cofirmed parent ion(m/z 397 [M+H]^+) to scan number 296 of total ion chromatogram. 4. We have succeeded in obtaining mass spectra of pre-D_2 and D_2 that does ...

  9. A Statistical Aggregation Engine for Climatology and Trend Analysis

    Science.gov (United States)

    Chapman, D. R.; Simon, T. A.; Halem, M.

    2014-12-01

    Fundamental climate data records (FCDRs) from satellite instruments often span tens to hundreds of terabytes or even petabytes in scale. These large volumes make it difficult to aggregate or summarize their climatology and climate trends. It is especially cumbersome to supply the full derivation (provenance) of these aggregate calculations. We present a lightweight and resilient software platform, Gridderama that simplifies the calculation of climatology by exploiting the "Data-Cube" topology often present in earth observing satellite records. By using the large array storage (LAS) paradigm, Gridderama allows the analyst to more easily produce a series of aggregate climate data products at progressively coarser spatial and temporal resolutions. Furthermore, provenance tracking and extensive visualization capabilities allow the analyst to track down and correct for data problems such as missing data and outliers that may impact the scientific results. We have developed and applied Gridderama to calculate a trend analysis of 55 Terabytes of AIRS Level 1b infrared radiances, and show statistically significant trending in the greenhouse gas absorption bands as observed by AIRS over the 2003-2012 decade. We will extend this calculation to show regional changes in CO2 concentration from AIRS over the 2003-2012 decade by using a neural network retrieval algorithm.

  10. A New Global Climatology of Annual Land Surface Temperature

    Directory of Open Access Journals (Sweden)

    Benjamin Bechtel

    2015-03-01

    Full Text Available Land surface temperature (LST is an important parameter in various fields including hydrology, climatology, and geophysics. Its derivation by thermal infrared remote sensing has long tradition but despite substantial progress there remain limited data availability and challenges like emissivity estimation, atmospheric correction, and cloud contamination. The annual temperature cycle (ATC is a promising approach to ease some of them. The basic idea to fit a model to the ATC and derive annual cycle parameters (ACP has been proposed before but so far not been tested on larger scale. In this study, a new global climatology of annual LST based on daily 1 km MODIS/Terra observations was processed and evaluated. The derived global parameters were robust and free of missing data due to clouds. They allow estimating LST patterns under largely cloud-free conditions at different scales for every day of year and further deliver a measure for its accuracy respectively variability. The parameters generally showed low redundancy and mostly reflected real surface conditions. Important influencing factors included climate, land cover, vegetation phenology, anthropogenic effects, and geology which enable numerous potential applications. The datasets will be available at the CliSAP Integrated Climate Data Center pending additional processing.

  11. Characteristics of cyclone climatology and variability in the Southern Ocean

    Institute of Scientific and Technical Information of China (English)

    WEI Lixin; QIN Ting

    2016-01-01

    A new climatology of cyclones in the Southern Ocean is generated by applying an automated cyclone detection and tracking algorithm (developed by Hodges at the Reading University) for an improved and relatively high-resolution European Centre for Medium-Range Weather Forecasts atmospheric reanalysis during 1979–2013. A validation shows that identified cyclone tracks are in good agreement with a available analyzed cyclone product. The climatological characteristics of the Southern Ocean cyclones are then analyzed, including track, number, density, intensity, deepening rate and explosive events. An analysis shows that the number of cyclones in the Southern Ocean has increased for 1979–2013, but only statistically significant in summer. Coincident with the circumpolar trough, a single high-density band of cyclones is observed in 55°–67°S, and cyclone density has generally increased in north of this band for 1979–2013, except summer. The intensity of up to 70% cyclones in the Southern Ocean is less than 980 hPa, and only a few cyclones with pressure less than 920 hPa are detected for 1979–2013. Further analysis shows that a high frequency of explosive cyclones is located in the band of 45°–55°S, and the Atlantic Ocean sector has much higher frequent occurrence of the explosive cyclones than that in the Pacific Ocean sector. Additionally, the relationship between cyclone activities in the Southern Ocean and the Southern Annular Mode is discussed.

  12. Extrastriatal dopamine D2-receptor availability in social anxiety disorder.

    Science.gov (United States)

    Plavén-Sigray, Pontus; Hedman, Erik; Victorsson, Pauliina; Matheson, Granville J; Forsberg, Anton; Djurfeldt, Diana R; Rück, Christian; Halldin, Christer; Lindefors, Nils; Cervenka, Simon

    2017-05-01

    Alterations in the dopamine system are hypothesized to influence the expression of social anxiety disorder (SAD) symptoms. However, molecular imaging studies comparing dopamine function between patients and control subjects have yielded conflicting results. Importantly, while all previous investigations focused on the striatum, findings from activation and blood flow studies indicate that prefrontal and limbic brain regions have a central role in the pathophysiology. The objective of this study was to investigate extrastriatal dopamine D2-receptor (D2-R) availability in SAD. We examined 12 SAD patients and 16 healthy controls using positron emission tomography and the high-affinity D2-R radioligand [(11)C]FLB457. Parametric images of D2-R binding potential were derived using the Logan graphical method with cerebellum as reference region. Two-tailed one-way independent ANCOVAs, with age as covariate, were used to examine differences in D2-R availability between groups using both region-based and voxel-wise analyses. The region-based analysis showed a medium effect size of higher D2-R levels in the orbitofrontal cortex (OFC) in patients, although this result did not remain significant after correction for multiple comparisons. The voxel-wise comparison revealed elevated D2-R availability in patients within OFC and right dorsolateral prefrontal cortex after correction for multiple comparisons. These preliminary results suggest that an aberrant extrastriatal dopamine system may be part of the disease mechanism in SAD. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  13. Atmospheric Rivers in the Southwestern US: Climatology and Possible Future Changes

    Science.gov (United States)

    Dominguez, F.; Rivera-fernandez, E. R.

    2014-12-01

    Atmospheric rivers (ARs) are important contributors to cool season precipitation in the Southwestern US, and in some cases can lead to extreme hydrometeorological events in the region. We performed a climatological analysis and identified two predominant types of ARs that affect the Southwest: Type 1 ARs originate in the tropics near Hawaii (central Pacific) and enhance their moisture in the midlatitudes, with maximum moisture transport over the ocean at low-levels of the troposphere. On the other hand, moisture in Type 2 ARs has a more direct tropical origin and meridional orientation with maximum moisture transfer at mid-levels. We then analyze future projections of Southwest ARs in a suite of global and regional climate models (from NARCCAP), to evaluate projected future changes in the frequency and intensity of ARs under warmer global climate conditions. We find a consistent and clear intensification of the water vapor transport associated with the ARs that impinge upon Arizona and adjacent regions, however, the response of AR-related precipitation intensity to increased moisture flux and column-integrated water vapor is weak and no robust variations are projected either by the GCMs or the NARCCAP models. To evaluate the effect of horizontal resolution and improve our physical understanding of these results, we numerically simulated a historical AR event using the Weather Research and Forecasting (WRF) model at a 3km resolution. We then performed a pseudo-global warming experiment by modifying the lateral and lower boundary conditions to reflect possible changes in future ARs (as projected by the ensemble of GCM simulations used for NARCCAP). Interestingly we find that despite higher specific humidity, some regions still receive less rainfall in the warming climate experiments - partially due to changes in thermodynamics, but primarily due to AR dynamics. Therefore, we conclude from this analysis that overall future increase in atmospheric temperature and water

  14. Heterotic $D=2 (1/3, 0)$ Susy Models

    CERN Document Server

    Sedra, M B

    2009-01-01

    Following our previous work on fractional spin symmetries (FSS) \\cite{2, 4}, we build here a superspace representation of the heterotic $D=2(1/3,0)$ superalgebra and derive a field theoretical model invariant under this symmetry.

  15. Quantitative imaging of D-2-hydroxyglutarate (D2HG in selected histological tissue areas by a novel bioluminescence technique

    Directory of Open Access Journals (Sweden)

    Nadine Fabienne Voelxen

    2016-03-01

    Full Text Available AbstractPatients with malignant gliomas have a poor prognosis with average survival of less than one year. Whereas in other tumor entities the characteristics of tumor metabolism are successfully used for therapeutic approaches, such developments are very rare in brain tumors, notably in gliomas. One metabolic feature characteristic of gliomas, in particular diffuse astrocytomas and oligodendroglial tumors, is the variable content of D-2-hydroxyglutarate (D2HG, a metabolite, which was discovered first in this tumor entity. D2HG is generated in large amounts due to various gain-of–function mutations in the isocitrate dehydrogenases IDH-1 and IDH-2. Meanwhile, D2HG has been detected in several other tumor entities including intrahepatic bile-duct cancer, chondrosarcoma, acute myeloid leukemia, and angioimmunoblastic T-cell lymphoma. D2HG is barely detectable in healthy tissue (< 0.1 mM, but its concentration increases up to 35 mM in malignant tumor tissues. Consequently, the oncometabolite D2HG has gained increasing interest in the field of tumor metabolism. To facilitate its quantitative measurement without loss of spatial resolution at a microscopical level, we have developed a novel bioluminescence assay for determining D2HG in sections of snap-frozen tissue. The assay was verified independently by photometric tests and liquid chromatography / mass spectrometry (LC/MS. The novel technique allows the microscopically resolved determination of D2HG in a concentration range of 0 – 10 µmol/g tissue (wet weight. In combination with the already established bioluminescence imaging techniques for ATP, glucose, pyruvate, and lactate, the novel D2HG assay enables a comparative characterization of the metabolic profile of individual tumors in a further dimension.

  16. Molecular dynamics simulations of D2O ice photodesorption

    CERN Document Server

    Arasa, C; Cuppen, H M; van Dishoeck, E F; Kroes, G J; 10.1063/1.3582910

    2011-01-01

    Molecular dynamics calculations have been performed to study the ultraviolet photodissociation of D2O in an amorphous D2O ice surface at 10-90 K, in order to investigate the influence of isotope effects on the photodesorption processes. As for H2O, the main processes after UV photodissociation are trapping and desorption. There are three desorption processes: D atom, OD radical, and D2O molecule photodesorption. D2O desorption takes places either by direct desorption of a recombined D2O molecule, or when an energetic D atom produced by photodissociation kicks a surrounding D2O molecule out of the surface by transferring part of its momentum. Desorption probabilities are compared quantitatively with those for H2O obtained from previous MD simulations of UV photodissociation of amorphous water ice. The main conclusions are the same, but the average D atom photodesorption probability is smaller than that of the H atom (by about a factor of 0.9) because D has lower kinetic energy than H, whereas the average OD ra...

  17. Abstraction the public from scientific - applied meteorological-climatologic data

    Science.gov (United States)

    Trajanoska, L.

    2010-09-01

    Mathematical and meteorological statistic processing of meteorological-climatologic data, which includes assessment of the exactness, level of confidence of the average and extreme values, frequencies (probabilities) of the occurrence of each meteorological phenomenon and element e.t.c. helps to describe the impacts climate may have on different social and economic activities (transportation, heat& power generation), as well as on human health. Having in mind the new technology and the commercial world, during the work with meteorological-climatologic data we have meet many different challenges. Priority in all of this is the quality of the meteorological-climatologic set of data. First, we need compatible modern, sophisticated measurement and informatics solution for data. Results of this measurement through applied processing and analyze is the second branch which is very important also. Should we all (country) need that? Today we have many unpleasant events connected with meteorology, many questions which are not answered and all of this has too long lasting. We must give the answers and solve the real and basic issue. In this paper the data issue will be presented. We have too much of data but so little of real and quality applied of them, Why? There is a data for: -public applied -for jurisdiction needs -for getting fast decision-solutions (meteorological-dangerous phenomenon's) -for getting decisions for long-lasting plans -for explore in different sphere of human living So, it is very important for what kind of data we are talking. Does the data we are talking are with public or scientific-applied character? So,we have two groups. The first group which work with the data direct from the measurement place and instrument. They are store a quality data base and are on extra help to the journalists, medical workers, human civil engineers, electromechanical engineers, agro meteorological and forestry engineer e.g. The second group do work with all scientific

  18. Annual Climatology of the Diurnal Cycle on the Canadian Prairies

    Directory of Open Access Journals (Sweden)

    Alan K Betts

    2016-01-01

    Full Text Available We show the annual climatology of the diurnal cycle, stratified by opaque cloud, using the full hourly resolution of the Canadian Prairie data. The opaque cloud field itself has distinct cold and warm season diurnal climatologies; with a near-sunrise peak of cloud in the cold season and an early afternoon peak in the warm season. There are two primary climate states on the Canadian Prairies, separated by the freezing point of water, because a reflective surface snow cover acts as a climate switch. Both cold and warm season climatologies can be seen in the transition months of November, March and April with a large difference in mean temperature. In the cold season with snow, the diurnal ranges of temperature and relative humidity increase quasi-linearly with decreasing cloud, and increase from December to March with increased solar forcing. The warm season months, April to September, show a homogeneous coupling to the cloud cover, and a diurnal cycle of temperature and humidity that depends only on net longwave. Our improved representation of the diurnal cycle shows that the warm season coupling between diurnal temperature range and net longwave is weakly quadratic through the origin, rather than the linear coupling shown in earlier papers. We calculate the conceptually important 24-h imbalances of temperature and relative humidity (and other thermodynamic variables as a function of opaque cloud cover. In the warm season under nearly clear skies, there is a warming of +2oC and a drying of -6% over the 24-h cycle, which is about 12% of their diurnal ranges. We summarize results on conserved variable diagrams and explore the impact of surface windspeed on the diurnal cycle in the cold and warm seasons. In all months, the fall in minimum temperature is reduced with increasing windspeed, which reduces the diurnal temperature range. In July and August, there is an increase of afternoon maximum temperature and humidity at low windspeeds, and a

  19. High resolution climatological wind measurements for wind energy applications

    Energy Technology Data Exchange (ETDEWEB)

    Bergstroem, H. [Uppsala Univ. (Sweden). Dept. of Meteorology

    1996-12-01

    Measurements with a combined cup anemometer/wind vane instrument, developed at the Department of Meteorology in Uppsala, is presented. The instrument has a frequency response of about 1 Hz, making it suitable not only for mean wind measurements, but also for studies of atmospheric turbulence. It is robust enough to be used for climatological purposes. Comparisons with data from a hot-film anemometer show good agreement, both as regards standard deviations and the spectral decomposition of the turbulent wind signal. The cup anemometer/wind vane instrument is currently used at three sites within the Swedish wind energy research programme. These measurements are shortly described, and a few examples of the results are given. 1 ref, 10 figs

  20. Eight-year Climatology of Dust Optical Depth on Mars

    CERN Document Server

    Montabone, L; Millour, E; Wilson, R J; Lewis, S R; Cantor, B A; Kass, D; Kleinboehl, A; Lemmon, M; Smith, M D; Wolff, M J

    2014-01-01

    We have produced a multiannual climatology of airborne dust from Martian year 24 to 31 using multiple datasets of retrieved or estimated column optical depths. The datasets are based on observations of the Martian atmosphere from April 1999 to July 2013 made by different orbiting instruments: the Thermal Emission Spectrometer (TES) aboard Mars Global Surveyor, the Thermal Emission Imaging System (THEMIS) aboard Mars Odyssey, and the Mars Climate Sounder (MCS) aboard Mars Reconnaissance Orbiter (MRO). The procedure we have adopted consists of gridding the available retrievals of column dust optical depth (CDOD) from TES and THEMIS nadir observations, as well as the estimates of this quantity from MCS limb observations. Our gridding method calculates averages and uncertainties on a regularly spaced, but possibly incomplete, spatio-temporal grid, using an iterative procedure weighted in space, time, and retrieval uncertainty. In order to evaluate strengths and weaknesses of the resulting gridded maps, we validat...

  1. 3D-2D registration of cerebral angiograms: a method and evaluation on clinical images.

    Science.gov (United States)

    Mitrovic, Uroš; Špiclin, Žiga; Likar, Boštjan; Pernuš, Franjo

    2013-08-01

    Endovascular image-guided interventions (EIGI) involve navigation of a catheter through the vasculature followed by application of treatment at the site of anomaly using live 2D projection images for guidance. 3D images acquired prior to EIGI are used to quantify the vascular anomaly and plan the intervention. If fused with the information of live 2D images they can also facilitate navigation and treatment. For this purpose 3D-2D image registration is required. Although several 3D-2D registration methods for EIGI achieve registration accuracy below 1 mm, their clinical application is still limited by insufficient robustness or reliability. In this paper, we propose a 3D-2D registration method based on matching a 3D vasculature model to intensity gradients of live 2D images. To objectively validate 3D-2D registration methods, we acquired a clinical image database of 10 patients undergoing cerebral EIGI and established "gold standard" registrations by aligning fiducial markers in 3D and 2D images. The proposed method had mean registration accuracy below 0.65 mm, which was comparable to tested state-of-the-art methods, and execution time below 1 s. With the highest rate of successful registrations and the highest capture range the proposed method was the most robust and thus a good candidate for application in EIGI.

  2. Improper activation of D1 and D2 receptors leads to excess noise in prefrontal cortex

    Science.gov (United States)

    Avery, Michael C.; Krichmar, Jeffrey L.

    2015-01-01

    The dopaminergic system has been shown to control the amount of noise in the prefrontal cortex (PFC) and likely plays an important role in working memory and the pathophysiology of schizophrenia. We developed a model that takes into account the known receptor distributions of D1 and D2 receptors, the changes these receptors have on neuron response properties, as well as identified circuitry involved in working memory. Our model suggests that D1 receptor under-stimulation in supragranular layers gates internal noise into the PFC leading to cognitive symptoms as has been proposed in attention disorders, while D2 over-stimulation gates noise into the PFC by over-activation of cortico-striatal projecting neurons in infragranular layers. We apply this model in the context of a memory-guided saccade paradigm and show deficits similar to those observed in schizophrenic patients. We also show set-shifting impairments similar to those observed in rodents with D1 and D2 receptor manipulations. We discuss how the introduction of noise through changes in D1 and D2 receptor activation may account for many of the symptoms of schizophrenia depending on where this dysfunction occurs in the PFC. PMID:25814948

  3. Improper activation of D1 and D2 receptors leads to excess noise in prefrontal cortex

    Directory of Open Access Journals (Sweden)

    Michael eAvery

    2015-03-01

    Full Text Available The dopaminergic system has been shown to control the amount of noise in the prefrontal cortex (PFC and likely plays an important role in working memory and the pathophysiology of schizophrenia. We developed a model that takes into account the known receptor distributions of D1 and D2 receptors, the changes these receptors have on neuron response properties, as well as identified circuitry involved in working memory. Our model suggests that D1 receptor under-stimulation in supragranular layers gates internal noise into the PFC leading to cognitive symptoms as has been proposed in attention disorders, while D2 over-stimulation gates noise into the PFC by over-activation of cortico-striatal projecting neurons in infragranular layers. We apply this model in the context of a memory-guided saccade paradigm and show deficits similar to those observed in schizophrenic patients. We also show set-shifting impairments similar to those observed in rodents with D1 and D2 receptor manipulations. We discuss how the introduction of noise through changes in D1 and D2 receptor activation may account for many of the symptoms of schizophrenia depending on where this dysfunction occurs in the PFC.

  4. Eight-year climatology of dust optical depth on Mars

    Science.gov (United States)

    Montabone, L.; Forget, F.; Millour, E.; Wilson, R. J.; Lewis, S. R.; Cantor, B.; Kass, D.; Kleinböhl, A.; Lemmon, M. T.; Smith, M. D.; Wolff, M. J.

    2015-05-01

    We have produced a multiannual climatology of airborne dust from martian year 24-31 using multiple datasets of retrieved or estimated column optical depths. The datasets are based on observations of the martian atmosphere from April 1999 to July 2013 made by different orbiting instruments: the Thermal Emission Spectrometer (TES) aboard Mars Global Surveyor, the Thermal Emission Imaging System (THEMIS) aboard Mars Odyssey, and the Mars Climate Sounder (MCS) aboard Mars Reconnaissance Orbiter (MRO). The procedure we have adopted consists of gridding the available retrievals of column dust optical depth (CDOD) from TES and THEMIS nadir observations, as well as the estimates of this quantity from MCS limb observations. Our gridding method calculates averages and uncertainties on a regularly spaced spatio-temporal grid, using an iterative procedure that is weighted in space, time, and retrieval quality. The lack of observations at certain times and locations introduces missing grid points in the maps, which therefore may result in irregularly gridded (i.e. incomplete) fields. In order to evaluate the strengths and weaknesses of the resulting gridded maps, we compare with independent observations of CDOD by PanCam cameras and Mini-TES spectrometers aboard the Mars Exploration Rovers "Spirit" and "Opportunity", by the Surface Stereo Imager aboard the Phoenix lander, and by the Compact Reconnaissance Imaging Spectrometer for Mars aboard MRO. We have statistically analyzed the irregularly gridded maps to provide an overview of the dust climatology on Mars over eight years, specifically in relation to its interseasonal and interannual variability, in addition to provide a basis for instrument intercomparison. Finally, we have produced regularly gridded maps of CDOD by spatially interpolating the irregularly gridded maps using a kriging method. These complete maps are used as dust scenarios in the Mars Climate Database (MCD) version 5, and are useful in many modeling

  5. Quantifying climatological ranges and anomalies for Pacific coral reef ecosystems.

    Science.gov (United States)

    Gove, Jamison M; Williams, Gareth J; McManus, Margaret A; Heron, Scott F; Sandin, Stuart A; Vetter, Oliver J; Foley, David G

    2013-01-01

    Coral reef ecosystems are exposed to a range of environmental forcings that vary on daily to decadal time scales and across spatial scales spanning from reefs to archipelagos. Environmental variability is a major determinant of reef ecosystem structure and function, including coral reef extent and growth rates, and the abundance, diversity, and morphology of reef organisms. Proper characterization of environmental forcings on coral reef ecosystems is critical if we are to understand the dynamics and implications of abiotic-biotic interactions on reef ecosystems. This study combines high-resolution bathymetric information with remotely sensed sea surface temperature, chlorophyll-a and irradiance data, and modeled wave data to quantify environmental forcings on coral reefs. We present a methodological approach to develop spatially constrained, island- and atoll-scale metrics that quantify climatological range limits and anomalous environmental forcings across U.S. Pacific coral reef ecosystems. Our results indicate considerable spatial heterogeneity in climatological ranges and anomalies across 41 islands and atolls, with emergent spatial patterns specific to each environmental forcing. For example, wave energy was greatest at northern latitudes and generally decreased with latitude. In contrast, chlorophyll-a was greatest at reef ecosystems proximate to the equator and northern-most locations, showing little synchrony with latitude. In addition, we find that the reef ecosystems with the highest chlorophyll-a concentrations; Jarvis, Howland, Baker, Palmyra and Kingman are each uninhabited and are characterized by high hard coral cover and large numbers of predatory fishes. Finally, we find that scaling environmental data to the spatial footprint of individual islands and atolls is more likely to capture local environmental forcings, as chlorophyll-a concentrations decreased at relatively short distances (>7 km) from 85% of our study locations. These metrics will help

  6. Quantifying climatological ranges and anomalies for Pacific coral reef ecosystems.

    Directory of Open Access Journals (Sweden)

    Jamison M Gove

    Full Text Available Coral reef ecosystems are exposed to a range of environmental forcings that vary on daily to decadal time scales and across spatial scales spanning from reefs to archipelagos. Environmental variability is a major determinant of reef ecosystem structure and function, including coral reef extent and growth rates, and the abundance, diversity, and morphology of reef organisms. Proper characterization of environmental forcings on coral reef ecosystems is critical if we are to understand the dynamics and implications of abiotic-biotic interactions on reef ecosystems. This study combines high-resolution bathymetric information with remotely sensed sea surface temperature, chlorophyll-a and irradiance data, and modeled wave data to quantify environmental forcings on coral reefs. We present a methodological approach to develop spatially constrained, island- and atoll-scale metrics that quantify climatological range limits and anomalous environmental forcings across U.S. Pacific coral reef ecosystems. Our results indicate considerable spatial heterogeneity in climatological ranges and anomalies across 41 islands and atolls, with emergent spatial patterns specific to each environmental forcing. For example, wave energy was greatest at northern latitudes and generally decreased with latitude. In contrast, chlorophyll-a was greatest at reef ecosystems proximate to the equator and northern-most locations, showing little synchrony with latitude. In addition, we find that the reef ecosystems with the highest chlorophyll-a concentrations; Jarvis, Howland, Baker, Palmyra and Kingman are each uninhabited and are characterized by high hard coral cover and large numbers of predatory fishes. Finally, we find that scaling environmental data to the spatial footprint of individual islands and atolls is more likely to capture local environmental forcings, as chlorophyll-a concentrations decreased at relatively short distances (>7 km from 85% of our study locations

  7. Climatological/meteorological and hydrological disasters and the insurance sector

    Directory of Open Access Journals (Sweden)

    Murat Türkeş

    2010-11-01

    Full Text Available Climate change is a continual fact during the Earth’s history. There had been many significant changes in the Earth’s climate during its evolutionary history and a lot of ecosystems had been affected by these changes. Especially the industrialization process showing rapid movement after industrial revolution has put serious pressure on the present and future climate. Human activities such as increased fossil fuel usage with the industrialization process, land-use changes, industrial processes and deforestation have increased atmospheric accumulation up of the various greenhouse gases such as carbon dioxide (CO2, methane (CH4, nitrous oxide (N2O. On the other hand, increase in frequency and severity of natural disasters can be explained mostly by the increase of the probability of extreme events due to the climate change. Increased numbers of people have been affected by climatological and meteorological catastrophes in every year. Various actions and activities such as disaster preparedness, mitigation, reduction and prevention of the impacts and early warnings are considerable with respect to the insurance sector. These activities and actions should be implemented in the frame of contemporary and comprehensive disaster management planes. Scope of the natural disaster should be expanded particularly in the countries and regions that are vulnerable to the impacts of the climate change and variability including drought events and/or natural disasters. Moreover, drought events should also be accepted as one of the severe natural disasters, and sustainable and applicable drought management plans should be developed in order to mitigate these disasters. In this context, main purpose of the study is to classify and shortly assess the climatological and meteorological disasters, and to attract attention necessity of a new disaster insurance system containing these disasters.

  8. Lightning climatology in the Congo Basin: detailed analysis

    Science.gov (United States)

    Soula, Serge; Kigotsi, Jean; Georgis, Jean-François; Barthe, Christelle

    2016-04-01

    The lightning climatology of the Congo Basin including several countries of Central Africa is analyzed in detail for the first time. It is based on World Wide Lightning Location Network (WWLLN) data for the period from 2005 to 2013. A comparison of these data with the Lightning Imaging Sensor (LIS) data for the same period shows the WWLLN detection efficiency (DE) in the region increases from about 1.70 % in the beginning of the period to 5.90 % in 2013, relative to LIS data, but not uniformly over the whole 2750 km × 2750 km area. Both the annual flash density and the number of stormy days show sharp maximum values localized in eastern of Democratic Republic of Congo (DRC) and west of Kivu Lake, regardless of the reference year and the period of the year. These maxima reach 12.86 fl km-2 and 189 days, respectively, in 2013, and correspond with a very active region located at the rear of the Virunga mountain range characterised with summits that can reach 3000 m. The presence of this range plays a role in the thunderstorm development along the year. The estimation of this local maximum of the lightning density by taking into account the DE, leads to a value consistent with that of the global climatology by Christian et al. (2003) and other authors. Thus, a mean maximum value of about 157 fl km-2 y-1 is found for the annual lightning density. The zonal distribution of the lightning flashes exhibits a maximum between 1°S and 2°S and about 56 % of the flashes located below the equator in the 10°S - 10°N interval. The diurnal evolution of the flash rate has a maximum between 1400 and 1700 UTC, according to the reference year, in agreement with previous works in other regions of the world.

  9. Revisiting the Climatology of Atmospheric Blocking in the Northern Hemisphere

    Institute of Scientific and Technical Information of China (English)

    Ho Nam CHEUNG; ZHOU Wen; Hing Yim MOK; Man Chi WU; Yaping SHAO

    2013-01-01

    In addition to the occurrence of atmospheric blocking,the climatology of the characteristics of blocking events,including duration,intensity,and extension,in four seasons over the Northern Hemisphere was analyzed for the period 1950-2009.The seasonality and spatial variations of these characteristics were studied according to their longitudinal distributions.In general,there were sharp discrepancies in the blocking characteristics between winter and summer,and these differences were more prominent over the Atlantic and Pacific Oceans.The blocking not only occurred more frequently but also underwent stronger amplification in winter; likewise,the blocking occurred less frequently and underwent weaker amplification in summer.There are very strong interrelationships among different blocking characteristics,suggesting that they are supported by similar physical factors.In addition,the relationship between blocking over different regions and East Asian circulation was examined.Ural-Siberia is a major blocking formation region in all seasons that may exert a downstream impact on East Asia.The impact is generally weak in summer,which is due to its lower intensity and smaller duration.However,the extratropical circulation over East Asia in summer can be disturbed persistently by the frequent occurrence of blocking over the Asian continent or the Western Pacific.In particular,the blocking frequency over the Western Pacific significantly increased during the study period.This climatological information provides a background for studying the impact of blocking on East Asian circulation under both present and future climate conditions.

  10. Fun Teaching: The Key to the Future Climatology

    Science.gov (United States)

    Mulvey, G.

    2016-12-01

    In general meteorology is a science of immediate impact. What will the weather be tomorrow or next week? Climatology and climate change is the science of our long range past and future. Decisions made in the past, now, and in the future on climate change issues did and will continue to impact the global climate. It is essential that current and future generations understand the causes of climate change to make informed decisions regarding individual and government actions needed to mitigate human impacts on the future climate. The university challenge is make climatology an exciting and dynamic adventure into the past, present and future. Instructor and supporting organizations have stepped outside the "old yellow notes" approach to enable students to progress beyond remember, understand, and apply; to analyze, evaluate and create. Responding to this instructional challenge by shifting instructional techniques and tools to a new paradigm does not happen overnight. The instructional strategies to make this jump are known in general, but not in specific. This paper deals with examples of how to translate the instructional strategies into practice in ways that are fun for students and instructors. Techniques to be described include interactive discussions, debates and team challenges, such as: - Describing continental climates during past geological periods - In-class teams debates on legislature to control/modify human CO2 releases Low or no cost teaching aids such as video clips, demonstrations, specimens, and experiments will be described with outcomes and resources interest. Some examples to be discussed are - Tree cookies, cross sections - Ocean core smear slide samples of diatoms, foraminifera, etc. - Ice pack/glacial melt experiments - Glacial flow and interpreting glacial ice cores experiment - Field trips to observe geological strata and geological samples - Storytelling - the shared experiences of each instructor

  11. Oscillation of Branching Ratios Between the D (2 s )+D (1 s ) and the D (2 p )+D (1 s ) Channels in Direct Photodissociation of D2

    Science.gov (United States)

    Wang, Jie; Meng, Qingnan; Mo, Yuxiang

    2017-08-01

    The direct photodissociation of D2 at excitation energies above 14.76 eV occurs via two channels, D (2 s )+D (1 s ) and D (2 p )+D (1 s ) . The branching ratios between the two have been measured from the dissociation threshold to 3200 cm-1 above it, and it is found that they show cosine oscillations as a function of the fragment wave vector magnitudes. The oscillation is due to an interference effect and can be simulated using the phase difference between the wave functions of the two channels, analogous to Young's double-slit experiment. By fitting the measured branching ratios, we have determined the depths and widths of the effective spherical potential wells related to the two channels, which are in agreement with the effective depths and widths of the ab initio interaction potentials. The results of this Letter illustrate the importance of the relative phase between the fragments in controlling the branching ratios of the photodissociation channels.

  12. Role of dopamine D2 receptors in human reinforcement learning.

    Science.gov (United States)

    Eisenegger, Christoph; Naef, Michael; Linssen, Anke; Clark, Luke; Gandamaneni, Praveen K; Müller, Ulrich; Robbins, Trevor W

    2014-09-01

    Influential neurocomputational models emphasize dopamine (DA) as an electrophysiological and neurochemical correlate of reinforcement learning. However, evidence of a specific causal role of DA receptors in learning has been less forthcoming, especially in humans. Here we combine, in a between-subjects design, administration of a high dose of the selective DA D2/3-receptor antagonist sulpiride with genetic analysis of the DA D2 receptor in a behavioral study of reinforcement learning in a sample of 78 healthy male volunteers. In contrast to predictions of prevailing models emphasizing DA's pivotal role in learning via prediction errors, we found that sulpiride did not disrupt learning, but rather induced profound impairments in choice performance. The disruption was selective for stimuli indicating reward, whereas loss avoidance performance was unaffected. Effects were driven by volunteers with higher serum levels of the drug, and in those with genetically determined lower density of striatal DA D2 receptors. This is the clearest demonstration to date for a causal modulatory role of the DA D2 receptor in choice performance that might be distinct from learning. Our findings challenge current reward prediction error models of reinforcement learning, and suggest that classical animal models emphasizing a role of postsynaptic DA D2 receptors in motivational aspects of reinforcement learning may apply to humans as well.

  13. Molecular dynamics simulations of D2O ice photodesorption

    Science.gov (United States)

    Arasa, C.; Andersson, S.; Cuppen, H.; van Dishoeck, E. F.; Kroes, G. J.

    2011-05-01

    We present results of MD calculations performed to study the photodissociation of D2O in an amorphous ice at different ice temperatures in order to investigate isotope effects on the photodesorption processes. In dense interstellar clouds, small dust particles of micrometer silicates are covered by ice mantles, mainly consisting of H2O and also of CO, CO2. Previous MD calculations of H2O ice at Tice=10-90 K show that the photodesorption of H while OH remains trapped is the main outcome in the first three monolayers (MLs). On the other hand, the H and OH photofragments released recombine or are trapped at separate positions in the deeper MLs and can react with other species in the ice. Desorption and trapping probabilities have been calculated following photoexcitation of D2O amorphous ice at 10, 20, 60 and 90 K, and the main conclusions agree with previous calculations of H2O ice. But, the average D photodesorption probability is smaller than that of the H atom, whereas the average OD radical photodesorption probability is larger than that of OH, and the average D2O photodesorption probability is larger than that for H2O due to the D2O kick-out mechanism. The total (OD + D2O) yield has been compared with experiments and the total (OH + H2O) yield from previous simulations. We find better agreement when we compare experimental yields with calculated yields for D2O ice than when we compare with calculated yields for H2O ice.

  14. Evidence against dopamine D1/D2 receptor heteromers

    Science.gov (United States)

    Frederick, Aliya L.; Yano, Hideaki; Trifilieff, Pierre; Vishwasrao, Harshad D.; Biezonski, Dominik; Mészáros, József; Sibley, David R.; Kellendonk, Christoph; Sonntag, Kai C.; Graham, Devon L.; Colbran, Roger J.; Stanwood, Gregg D.; Javitch, Jonathan A.

    2014-01-01

    Hetero-oligomers of G-protein-coupled receptors have become the subject of intense investigation because their purported potential to manifest signaling and pharmacological properties that differ from the component receptors makes them highly attractive for the development of more selective pharmacological treatments. In particular, dopamine D1 and D2 receptors have been proposed to form hetero-oligomers that couple to Gαq proteins, and SKF83959 has been proposed to act as a biased agonist that selectively engages these receptor complexes to activate Gαq and thus phospholipase C. D1/D2 heteromers have been proposed as relevant to the pathophysiology and treatment of depression and schizophrenia. We used in vitro bioluminescence resonance energy transfer (BRET), ex vivo analyses of receptor localization and proximity in brain slices, and behavioral assays in mice to characterize signaling from these putative dimers/oligomers. We were unable to detect Gαq or Gα11 protein coupling to homomers or heteromers of D1 or D2 receptors using a variety of biosensors. SKF83959-induced locomotor and grooming behaviors were eliminated in D1 receptor knockout mice, verifying a key role for D1-like receptor activation. In contrast, SKF83959-induced motor responses were intact in D2 receptor and Gαq knockout mice, as well as in knock-in mice expressing a mutant Ala286-CaMKIIα, that cannot autophosphorylate to become active. Moreover, we found that in the shell of the nucleus accumbens, even in neurons in which D1 and D2 receptor promoters are both active, the receptor proteins are segregated and do not form complexes. These data are not compatible with SKF83959 signaling through Gαq or through a D1–D2 heteromer and challenge the existence of such a signaling complex in the adult animals that we used for our studies. PMID:25560761

  15. Musical Expression with the D2MMG Interface

    DEFF Research Database (Denmark)

    Jensen, Karl Kristoffer; Graugaard, Lars

    2006-01-01

    Distribution in Multiple Musical Gestures (D2MMG) uses a robust interface for detecting simple drawing gestures. The gestures affect low- and high-level aspects of sound and music through inherent modes organized as primary and secondary gestures. This enables expressive live performance...... and improvisation with sequence creation where musical elements such as tonality, chromaticity, rhythm patterns, and melodical sequences can be affected in real-time. We introduce a utility for procedurally controlling note density and chordal alignment. Future papers will focus on D2MMG’s progressive learning...

  16. Musical Expression with the D2MMG Interface

    DEFF Research Database (Denmark)

    Jensen, Karl Kristoffer; Graugaard, Lars

    2006-01-01

    Distribution in Multiple Musical Gestures (D2MMG) uses a robust interface for detecting simple drawing gestures. The gestures affect low- and high-level aspects of sound and music through inherent modes organized as primary and secondary gestures. This enables expressive live performance...... and improvisation with sequence creation where musical elements such as tonality, chromaticity, rhythm patterns, and melodical sequences can be affected in real-time. We introduce a utility for procedurally controlling note density and chordal alignment. Future papers will focus on D2MMG’s progressive learning...

  17. Tourism climatology past and present: A review of the role of the ISB Commission on Climate, Tourism and Recreation

    Science.gov (United States)

    de Freitas, C. R.

    2017-09-01

    The Executive Board of the International Society of Biometeorology (ISB) founded the Commission on Climate, Tourism and Recreation (CCTR) at the 15th International Congress of Biometeorology in Sydney, Australia in 1999. The aims of the CCTR are to bring together researchers from around the world to critically review the current state of knowledge in tourism and recreation climatology and explore possibilities for future research. Almost two decades on, research in tourism climatology has developed and expanded due in large part to the initiatives and activities of the CCTR and several collaborative research projects run under the auspices of the CCTR. This work is reviewed here. Recent CCTR meeting highlighted the fact that, although climate is an essential part of the resource base for tourism, which is one of the world's biggest and fastest growing industries, relatively little is known about the effects of climate on tourist choices and broad demand patterns or the influence climate has on the commercial prospects and sustainability of tourism operators and destinations. The work here reviews what has been done, its conceptual underpinnings and current research frontiers.

  18. Tourism climatology past and present: A review of the role of the ISB Commission on Climate, Tourism and Recreation

    Science.gov (United States)

    de Freitas, C. R.

    2017-06-01

    The Executive Board of the International Society of Biometeorology (ISB) founded the Commission on Climate, Tourism and Recreation (CCTR) at the 15th International Congress of Biometeorology in Sydney, Australia in 1999. The aims of the CCTR are to bring together researchers from around the world to critically review the current state of knowledge in tourism and recreation climatology and explore possibilities for future research. Almost two decades on, research in tourism climatology has developed and expanded due in large part to the initiatives and activities of the CCTR and several collaborative research projects run under the auspices of the CCTR. This work is reviewed here. Recent CCTR meeting highlighted the fact that, although climate is an essential part of the resource base for tourism, which is one of the world's biggest and fastest growing industries, relatively little is known about the effects of climate on tourist choices and broad demand patterns or the influence climate has on the commercial prospects and sustainability of tourism operators and destinations. The work here reviews what has been done, its conceptual underpinnings and current research frontiers.

  19. Spatially adaptive probabilistic computation of a sub-kilometre resolution lightning climatology for New Zealand

    Science.gov (United States)

    Etherington, Thomas R.; Perry, George L. W.

    2017-01-01

    Lightning is a key component of the Earth's atmosphere and climate systems, and there is a potential positive feedback between a warming climate and increased lightning activity. In the biosphere, lightning is important as the main natural ignition source for wildfires and because of its contribution to the nitrogen cycle. Therefore, it is important to develop lightning climatologies to characterise and monitor lightning activity. While traditional methods for constructing lightning climatologies are suitable for examining lightning's influence on atmospheric processes, they are less well suited for examining questions about biosphere-lightning interactions. For example, examining the interaction between lightning and wildfires requires linking atmospheric processes to finer scale terrestrial processes and patterns. Most wildfires ignited by lightning are less than one hectare in size, and so require lightning climatologies at a comparable spatial resolution. However, such high resolution lightning climatologies cannot be derived using the traditional cell-count methodology. Here we present a novel geocomputational approach for analysing lightning data at high spatial resolutions. Our approach is based on probabilistic computational methods and is capable of producing a sub-kilometre lightning climatology that honours the spatial accuracy of the strike locations and is adaptive to underlying spatial patterns. We demonstrate our methods by applying them to the mid-latitude oceanic landmass of New Zealand, an area with geographic conditions that are under-represented in existing lightning climatologies. Our resulting lightning climatology has unparalleled spatial resolution, and the spatial and temporal patterns we observe in it are consistent with other continental and tropical lightning climatologies. To encourage further use and development of our probabilistic approach, we provide Python scripts that demonstrate the method alongside our resulting New Zealand

  20. Available climatological and oceanographical data for site investigation program

    Energy Technology Data Exchange (ETDEWEB)

    Lindell, S.; Ambjoern, C.; Juhlin, B.; Larsson-McCann, S.; Lindquist, K. [Swedish Meteorological and Hydrological Inst., Norrkoeping (Sweden)

    2000-03-15

    Information on available data, measurements and models for climate, meteorology, hydrology and oceanography for six communities have been analysed and studied. The six communities are Nykoeping, Oesthammar, Oskarshamn, Tierp, Hultsfred and Aelvkarleby all of them selected by Svensk Kaernbraenslehantering AB, SKB, for a pre-study on possibilities for deep disposal of used nuclear fuel. For each of them a thorough and detailed register of available climatological data together with appropriate statistical properties are listed. The purpose is to compare the six communities concerning climatological and oceanographical data available and analyse the extent of new measurements or model applications needed for all of the selected sites. Statistical information on precipitation, temperature and runoff has good coverage in all of the six communities. If new information concerning any of these variables is needed in sites where no data collection exist today new installation can be made. Data on precipitation in form of snow and days with snow coverage is also available but to a lesser extent. This concerns also days with ground frost and average ground frost level where there is no fully representation of data. If more information is wanted concerning these variables new measurements or model calculations must be initiated. Data on freeze and break-up of ice on lakes is also insufficient but this variable can be calculated with good result by use of one-dimensional models. Data describing air pressure tendency and wind velocity and direction is available for all communities and this information should be sufficient for the purpose of SKB. This is also valid for the variables global radiation and duration of sunshine where no new data should be needed. Measured data on evaporation is normally not available in Sweden more than in special research basins. Actual evaporation is though a variable that easily can be calculated by use of models. There are many lakes in the six

  1. A Precipitation Climatology of the Snowy Mountains, Australia

    Science.gov (United States)

    Theobald, Alison; McGowan, Hamish; Speirs, Johanna

    2014-05-01

    The precipitation that falls in the Snowy Mountains region of southeastern Australia provides critical water resources for hydroelectric power generation. Water storages in this region are also a major source of agricultural irrigation, environmental flows, and offer a degree of flood protection for some of the major river systems in Australia. Despite this importance, there remains a knowledge gap regarding the long-term, historic variability of the synoptic weather systems that deliver precipitation to the region. This research aims to increase the understanding of long-term variations in precipitation-bearing weather systems resulting in runoff into the Snowy Mountains catchments and reservoirs, and the way in which these are influenced by large-scale climate drivers. Here we present initial results on the development of a climatology of precipitation-bearing synoptic weather systems (synoptic typology), spanning a period of over 100 years. The synoptic typology is developed from the numerical weather model re-analysis data from the European Centre for Medium-Range Weather Forecasts (ECMWF), in conjunction with regional precipitation and temperature data from a network of private gauges. Given the importance of surface, mid- and upper-air patterns on seasonal precipitation, the synoptic typing will be based on a range of meteorological variables throughout the depth of the troposphere, highlighting the importance of different atmospheric levels on the development and steering of synoptic precipitation bearing systems. The temporal and spatial variability of these synoptic systems, their response to teleconnection forcings and their contribution to inflow generation in the headwater catchments of the Snowy Mountains will be investigated. The resulting climatology will provide new understanding of the drivers of regional-scale precipitation variability at inter- and intra-annual timescales. It will enable greater understanding of how variability in synoptic scale

  2. Climatological context for large-scale coral bleaching

    Science.gov (United States)

    Barton, A. D.; Casey, K. S.

    2005-12-01

    Large-scale coral bleaching was first observed in 1979 and has occurred throughout virtually all of the tropics since that time. Severe bleaching may result in the loss of live coral and in a decline of the integrity of the impacted coral reef ecosystem. Despite the extensive scientific research and increased public awareness of coral bleaching, uncertainties remain about the past and future of large-scale coral bleaching. In order to reduce these uncertainties and place large-scale coral bleaching in the longer-term climatological context, specific criteria and methods for using historical sea surface temperature (SST) data to examine coral bleaching-related thermal conditions are proposed by analyzing three, 132 year SST reconstructions: ERSST, HadISST1, and GISST2.3b. These methodologies are applied to case studies at Discovery Bay, Jamaica (77.27°W, 18.45°N), Sombrero Reef, Florida, USA (81.11°W, 24.63°N), Academy Bay, Galápagos, Ecuador (90.31°W, 0.74°S), Pearl and Hermes Reef, Northwest Hawaiian Islands, USA (175.83°W, 27.83°N), Midway Island, Northwest Hawaiian Islands, USA (177.37°W, 28.25°N), Davies Reef, Australia (147.68°E, 18.83°S), and North Male Atoll, Maldives (73.35°E, 4.70°N). The results of this study show that (1) The historical SST data provide a useful long-term record of thermal conditions in reef ecosystems, giving important insight into the thermal history of coral reefs and (2) While coral bleaching and anomalously warm SSTs have occurred over much of the world in recent decades, case studies in the Caribbean, Northwest Hawaiian Islands, and parts of other regions such as the Great Barrier Reef exhibited SST conditions and cumulative thermal stress prior to 1979 that were comparable to those conditions observed during the strong, frequent coral bleaching events since 1979. This climatological context and knowledge of past environmental conditions in reef ecosystems may foster a better understanding of how coral reefs will

  3. Predictability and Diagnostics of Western Himalayan Hydro-climatology

    Science.gov (United States)

    Pal, I.; Lall, U.; Robertson, A. W.; Cane, M. A.

    2011-12-01

    Snowmelt dominated streamflow of the Western Himalayan rivers is an important water resource during the dry pre-monsoon months to meet the irrigation and hydropower needs in northern India. On the other hand, winter precipitation as the form of snow over Himalayas helps in maintaining the glaciers, which serve as a storehouse of freshwater throughout the year. With the help of the hydro-climatological data provided by the Bhakra Beas Management Board in India, we present the outcome of our research on the prediction and diagnostics of Satluj river basin hydro-climatology at the Indian side up to the upstream of Bhakra dam, which is a major source of water for irrigation and electricity generation (1325MW) for north India. Spring seasonal inflow anomalies to Bhakra dam are strongly correlated with large-scale precipitation and temperature in the preceding winter over the Western Himalayas and adjoining north and central Indian plains, suggesting a potentially usable predictability for reservoir managers. Winter precipitation in the Western Himalayas is mainly brought about by the mid-latitude jet stream leading to the formation of low-pressure synoptic systems known as Western Disturbances (WD). WDs originate over the North Atlantic Ocean or Mediterranean Sea, with secondaries developing over the Persian Gulf and Caspian Sea either directly or as a result of the arrival of low-pressure systems from southwest Arabia, and travel eastward over Iran, Afghanistan, Pakistan, and northwest India. Winter WDs (and therefore the average volume of winter precipitation over Western Himalayas) are also modulated by the large-scale interaction between ocean and atmosphere led by the variation of the SSTs of the Indian Ocean and Pacific. As a result, average spring inflow volume, which is a function of the average volume of precipitation in winter, was also found to be positively correlated with the SSTs over the western and equatorial Indian Ocean, and with below-normal sea

  4. The climatology of dust aerosol over the arabian peninsula

    Directory of Open Access Journals (Sweden)

    A. Shalaby

    2015-01-01

    Full Text Available Dust storms are considered to be a natural hazard over the Arabian Peninsula, since they occur all year round with maximum intensity and frequency in Spring and Summer. The Regional Climate Model version 4 (RegCM4 has been used to study the climatology of atmospheric dust over the Arabian Peninsula from 1999 to 2012. This relatively long simulation period samples the meteorological conditions that determine the climatology of mineral dust aerosols over the Arabian Peninsula. The modeled Aerosol Optical Depth (AOD has been compared against ground-based observations of three Aerosol Robotic Network (AERONET stations that are distributed over the Arabian Peninsula and daily space based observations from the Multi-angle Imaging SpectroRadiometer (MISR, the Moderate resolution Imaging SpectroRadimeter (MODIS and Ozone Monitoring Instrument (OMI. The large scale atmospheric circulation and the land surface response that lead to dust uplifting have been analyzed. While the modeled AOD shows that the dust season extends from March to August with two pronounced maxima, one over the northern Arabian Peninsula in March with AOD equal to 0.4 and one over the southern Arabian Peninsula in July with AOD equal to 0.7, the observations show that the dust season extends from April to August with two pronounced maxima, one over the northern Arabian Peninsula in April with AOD equal to 0.5 and one over the southern Arabian Peninsula in July with AOD equal to 0.5. In spring a high pressure dominates the Arabian Peninsula and is responsible for advecting dust from southern and western part of the Arabian Peninsula to northern and eastern part of the Peninsula. Also, fast developed cyclones in northern Arabian Peninsula are responsible for producing strong dust storms over Iraq and Kuwait. However, in summer the main driver of the surface dust emission is the strong northerly wind ("Shamal" that transport dust from the northern Arabian Peninsula toward south parallel

  5. Moisture and heat budgets of the south American monsoon system: climatological aspects

    Science.gov (United States)

    Garcia, Sâmia R.; Kayano, Mary T.; Calheiros, Alan J. P.; Andreoli, Rita Valéria; de Souza, Rodrigo Augusto Ferreira

    2016-08-01

    The climatology of the moisture and heat budget equation terms for subareas within the South American Monsoon System (SAMS) region is investigated for the 1958-2014 period considering the distinct phases of the Pacific Decadal Oscillation (PDO). These budget equations are applied to the data from the National Centers for Environmental Prediction (NCEP) Reanalysis project. Sources or sinks of moisture and heat are equation residues, referred to as residue and diabatic terms, respectively. Analyses are done for the Central Amazon Basin (CAM) and Western-Central Brazil (WCB) for three distinct periods, 1958-1976, 1977-1995, and 1996-2014, that correspond to the cold, warm, and undefined PDO phases. The differences among the PDO phases for each term are discussed. The CAM region acts dominantly as a moisture sink and heat source in all months during the three phases. On the other hand, in the WCB region, the monsoon characteristics are better defined, with a moisture sink (source) and a heat source (sink) during the wet (dry) season. The main result of the present analysis is the persistence of SAMS intensification signs in both CAM and WCB areas up to the last analyzed period (1996-2014), which is consistent with intense flooding in the Amazon Basin in 2008/2009, 2012, and 2014.

  6. Human cognitive flexibility depends on dopamine D2 receptor signaling

    NARCIS (Netherlands)

    Holstein, M.G.A. van; Aarts, E.; Schaaf, M.E. van der; Geurts, D.E.M.; Verkes, R.J.; Franke, B.; Schouwenburg, M.R. van; Cools, R.

    2011-01-01

    RATIONALE: Accumulating evidence indicates that the cognitive effects of dopamine depend on the subtype of dopamine receptor that is activated. In particular, recent work with animals as well as current theorizing has suggested that cognitive flexibility depends on dopamine D2 receptor signaling.

  7. Association of Dopamine D2 Receptor Gene with Creative Ideation

    Science.gov (United States)

    Yu, Qi; Zhang, Shun; Zhang, Jinghuan H.

    2017-01-01

    Although several studies suggest that dopamine D2 receptor (DRD2) gene may contribute to creativity, the relationship between DRD2 and creativity still needs to be further validated. To further test the relevance of DRD2 and creativity, this study explored the association between DRD2 and creative ideation in 483 unrelated healthy Chinese…

  8. Path integral approach to bosonization of D=2 field theories

    CERN Document Server

    Kiyanov-Charsky, S A

    1995-01-01

    We suggest a method of bosonizing any D=2 theory. We demonstrate how it works with the examples of the Thirring and the Schwinger models, known results are reproduced. This method, being applied to the Gross-Neveu model, yields nonlinear boson WZW-type theory with additional constraint in the field space. Relation to the nonlinear sigma - model is also discussed.

  9. Depletion studies of two contrasting D-2 reefs

    Energy Technology Data Exchange (ETDEWEB)

    Gillund, G.N.; Patel, C.

    1980-01-01

    The Nisku B and G pools are 2 W. Pembina D-2 pools with contrasting reservoir properties. Average porosity, permeability, and maximum thickness are 5%, 130 md, and 95 m; and 16.4%, 7100 md and 19 m, respectively. The results of the depletion model studies of waterflooding and miscible flooding and some of the problems that occurred during these studies are reviewed.

  10. Temporal and Spatial Changes in Northern Hemisphere Floating Climatological Seasons

    Science.gov (United States)

    Choi, G.; Robinson, D. A.

    2007-12-01

    Floating climatological seasons, for which onsets and durations vary temporally and spatially, are examined over Northern Hemisphere continents and oceans. Among the variables evaluated are surface air temperature, snow extent, vegetation greenness, and atmospheric carbon dioxide concentrations. Seasonal thresholds are defined for each variable (e.g. daily mean temperature exceeding 5°C (20°C) to mark the beginning of spring (summer)). The dates on which these thresholds are reached at a given location are determined for each year over the past three decades. These seasonal onsets and offsets "float" temporally and spatially from year to another. An analysis of floating dates finds that winter duration has shortened in Europe, eastern Asia, and western North America, primarily due to an earlier spring onset. The spatial pattern of this earlier onset is associated with a positive Arctic Oscillation (AO) regime in the previous winter months. The positive winter AO finds anomalously high pressure sitting in the middle latitudes in locations where spring arrives early. This is likely due to a combination of advective fluxes of warmth and moisture and the local enhancement of solar radiation reaching the surface under clear skies. This, in turn, promotes earlier snow melt that further enhances warming and an earlier green-up. Extended summer duration is observed over continents and oceans (except the Arctic Ocean, where summer does not exist). The oceanic zone along 30°N has experienced a particularly large increase in duration, suggesting Hadley cell expansion.

  11. Synoptic and climatological aspects of extra-tropical cyclones

    Science.gov (United States)

    Leckebusch, G. C.

    2010-09-01

    Mid-latitude cyclones are highly complex dynamical features embedded in the general atmospheric circulation of the extra-tropics. Although the basic mechanisms leading to the formation of cyclones are commonly understood, the specific conditions and physical reasons triggering extreme, partly explosive development, are still under investigation. This includes also the identification of processes which might modulate the frequency and intensity of cyclone systems on time scales from days to centennials. This overview presentation will thus focus on three main topics: Firstly, the dynamic-synoptic structures of cyclones, the possibility to objectively identify cyclones and wind storms, and actual statistical properties of cyclone occurrence under recent climate conditions are addressed. In a second part, aspects of the interannual variability and its causing mechanisms are related to the seasonal predictability of extreme cyclones producing severe storm events. Extending the time frame will mean to deduce information on decadal or even centennial time periods. Thus, actual work to decadal as well as climatological variability and changes will be presented. In the last part of the talk focus will be laid on potential socio-economical impacts of changed cyclone occurrence. By means of global and regional climate modeling, future damages in terms of insured losses will be investigated and measures of uncertainty estimated from a multi-model ensemble analysis will be presented.

  12. Borneo Vortices: A case study and its relation to climatology

    Science.gov (United States)

    Braesicke, P.; Ooi, S. H.; Samah, A. A.

    2012-04-01

    Borneo vortices (BVs) develop over the South China Sea and are main drivers for the formation of deep convection and heavy rainfall in East Malaysia. We present a case study of a cold-surge-induced BV during January 2010 in which the export of potential energy lead to a strengthening of the subtropical jet. Potential vorticity (PV) and water vapour analyses confirm a significant impact of the BV on upper tropospheric composition. Dry, high PV air is found far below 100 hPa in the vicinty of the vortex. Using a PV threshold analysis of ERA-Interim data we construct a climatological composite of similar events and characterise the thermal, dynamical and composition structure of a 'typical' BV. We note the preferential formation of BVs during ENSO cold conditions and show that two effects contribute to the formation of the dry upper layer above a BV: Air is vertically transported upwards in the BV whilst precipitating and the large scale flow in which the BV is embedded advect dry, ozone rich air from the equatorial TTL over the BV. Thus the occurence frequency of BVs is important for the regional variability of upper tropospheric/lower stratospheric composition.

  13. Climatology characterization of equatorial plasma bubbles using GPS data

    Science.gov (United States)

    Magdaleno, Sergio; Herraiz, Miguel; Altadill, David; de la Morena, Benito A.

    2017-01-01

    The climatology of equatorial plasma bubbles (EPBs) for the period 1998-2008 was studied using slant total electron content (sTEC) derived from global positioning system (GPS) data. The sTEC values were calculated from data measured at 67 International GNSS Service (IGS) stations distributed worldwide around the geomagnetic equator and embracing the region of the ionospheric equatorial anomaly (IEA). EPBs and their characteristics were obtained using the Ionospheric Bubble Seeker (IBS) application, which detects and distinguishes sTEC depletions associated with EPBs. This technique bases its analysis on the time variation of the sTEC and on the population variance of this time variation. IBS finds an EPB by default when an sTEC depletion is greater than 5 TEC units (TECu). The analysis of the spatial behavior shows that the largest rate of EPB takes place at the equator and in the South America-Africa sector, while their occurrence decreases as the distance from the magnetic equator increases. The depth and duration of the sTEC depletions also maximize at the equator and in the South America-Africa sector and weaken departing from the equator. The results of the temporal analysis for the data of the IGS stations located in AREQ, NKLG, IISC, and GUAM indicate that the greatest rate of EPB occurrence is observed for high solar activity.

  14. Climatology characterization of equatorial plasma bubbles using GPS data

    Directory of Open Access Journals (Sweden)

    Magdaleno Sergio

    2017-01-01

    Full Text Available The climatology of equatorial plasma bubbles (EPBs for the period 1998–2008 was studied using slant total electron content (sTEC derived from global positioning system (GPS data. The sTEC values were calculated from data measured at 67 International GNSS Service (IGS stations distributed worldwide around the geomagnetic equator and embracing the region of the ionospheric equatorial anomaly (IEA. EPBs and their characteristics were obtained using the Ionospheric Bubble Seeker (IBS application, which detects and distinguishes sTEC depletions associated with EPBs. This technique bases its analysis on the time variation of the sTEC and on the population variance of this time variation. IBS finds an EPB by default when an sTEC depletion is greater than 5 TEC units (TECu. The analysis of the spatial behavior shows that the largest rate of EPB takes place at the equator and in the South America-Africa sector, while their occurrence decreases as the distance from the magnetic equator increases. The depth and duration of the sTEC depletions also maximize at the equator and in the South America-Africa sector and weaken departing from the equator. The results of the temporal analysis for the data of the IGS stations located in AREQ, NKLG, IISC, and GUAM indicate that the greatest rate of EPB occurrence is observed for high solar activity.

  15. A model of the tropical Pacific sea surface temperature climatology

    Science.gov (United States)

    Seager, Richard; Zebiak, Stephen E.; Cane, Mark A.

    1988-01-01

    A model for the climatological mean sea surface temperature (SST) of the tropical Pacific Ocean is developed. The upper ocean response is computed using a time dependent, linear, reduced gravity model, with the addition of a constant depth frictional surface layer. The full three-dimensional temperature equation and a surface heat flux parameterization that requires specification of only wind speed and total cloud cover are used to evaluate the SST. Specification of atmospheric parameters, such as air temperature and humidity, over which the ocean has direct influence, is avoided. The model simulates the major features of the observed tropical Pacific SST. The seasonal evolution of these features is generally captured by the model. Analysis of the results demonstrates the control the ocean has over the surface heat flux from ocean to atmosphere and the crucial role that dynamics play in determining the mean SST in the equatorial Pacific. The sensitivity of the model to perturbations in the surface heat flux, cloud cover specification, diffusivity, and mixed layer depth is discussed.

  16. On the fall 2010 Enhancements of the Global Precipitation Climatology Centre's Data Sets

    Science.gov (United States)

    Becker, A. W.; Schneider, U.; Meyer-Christoffer, A.; Ziese, M.; Finger, P.; Rudolf, B.

    2010-12-01

    Precipitation is meanwhile a top listed parameter on the WMO GCOS list of 44 essential climate variables (ECV). This is easily justified by its crucial role to sustain any form of life on earth as major source of fresh water, its major impact on weather, climate, climate change and related issues of society’s adaption to the latter. Finally its occurrence is highly variable in space and time thus bearing the potential to trigger major flood and draught related disasters. Since its start in 1989 the Global precipitation Climatology Centre (GPCC) performs global analyses of monthly precipitation for the earth’s land-surface on the basis of in-situ measurements. The effort was inaugurated as part of the Global Precipitation Climatology Project of the WMO World Climate Research Program (WCRP). Meanwhile, the data set has continuously grown both in temporal coverage (original start of the evaluation period was 1986), as well as extent and quality of the underlying data base. The number of stations involved in the related data base has approximately doubled in the past 8 years by trespassing the 40, 60 and 80k thresholds in 2002, 2006 and 2010. Core data source of the GPCC analyses are the data from station networks operated by the National Meteorological Services worldwide; data deliveries have been received from ca. 190 countries. The GPCC integrates also other global precipitation data collections (i.e. FAO, CRU and GHCN), as well as regional data sets. Currently the Africa data set from S. Nicholson (Univ. Tallahassee) is integrated. As a result of these efforts the GPCC holds the worldwide largest and most comprehensive collection of precipitation data, which is continuously updated and extended. Due to the high spatial-temporal variability of precipitation, even its global analysis requires this high number of stations to provide for a sufficient density of measurement data on almost any place on the globe. The acquired data sets are pre-checked, reformatted

  17. East Asian Seas Regional Climatology Version 2.0 from 1804 to 2014 (NODC Accession 0123300)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The East Asian Seas Regional Climatology Version 2.0 is an update to the preliminary version released in May 2012. This update includes new temperature and salinity...

  18. SST Anomaly, NOAA POES AVHRR, Casey and Cornillon Climatology, 0.1 degrees, Global

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA CoastWatch distributes SST anomaly data using a combination of the POES AVHRR Global Area Coverage data, and data from a climatological database by Casey and...

  19. Monthly Summaries of the Global Historical Climatology Network - Daily (GHCN-D)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Monthly Summaries of Global Historical Climatology Network (GHCN)-Daily is a dataset derived from GHCN-Daily. The data are produced by computing simple averages or...

  20. SST Anomaly, NOAA POES AVHRR, Casey and Cornillon Climatology, 0.1 degrees, Global

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA CoastWatch distributes SST anomaly data using a combination of the POES AVHRR Global Area Coverage data, and data from a climatological database by Casey and...

  1. Extending and Merging the Purple Crow Lidar Temperature Climatologies Using the Inversion Method

    Science.gov (United States)

    Jalali, Ali; Sica, R. J.; Argall, P. S.

    2016-06-01

    Rayleigh and Raman scatter measurements from The University of Western Ontario Purple Crow Lidar (PCL) have been used to develop temperature climatologies for the stratosphere, mesosphere, and thermosphere using data from 1994 to 2013 (Rayleigh system) and from 1999 to 2013 (vibrational Raman system). Temperature retrievals from Rayleigh-scattering lidar measurements have been performed using the methods by Hauchecorne and Chanin (1980; henceforth HC) and Khanna et al. (2012). Argall and Sica (2007) used the HC method to compute a climatology of the PCL measurements from 1994 to 2004 for 35 to 110 km, while Iserhienrhien et al. (2013) applied the same technique from 1999 to 2007 for 10 to 35 km. Khanna et al. (2012) used the inversion technique to retrieve atmospheric temperature profiles and found that it had advantages over the HC method. This paper presents an extension of the PCL climatologies created by Argall and Sica (2007) and Iserhienrhien et al. (2013). Both the inversion and HC methods were used to form the Rayleigh climatology, while only the latter was adopted for the Raman climatology. Then, two different approaches were used to merge the climatologies from 10 to 110 km. Among four different functional identities, a trigonometric hyperbolic relation results in the best choice for merging temperature profiles between the Raman and Low level Rayleigh channels, with an estimated uncertainty of 0.9 K for merging temperatures. Also, error function produces best result with uncertainty of 0.7 K between the Low Level Rayleigh and High Level Rayleigh channels. The results show that the temperature climatologies produced by the HC method when using a seed pressure are comparable to the climatologies produced by the inversion method. The Rayleigh extended climatology is slightly warmer below 80 km and slightly colder above 80 km. There are no significant differences in temperature between the extended and the previous Raman channel climatologies. Through out

  2. Extending and Merging the Purple Crow Lidar Temperature Climatologies Using the Inversion Method

    Directory of Open Access Journals (Sweden)

    Jalali Ali

    2016-01-01

    Full Text Available Rayleigh and Raman scatter measurements from The University of Western Ontario Purple Crow Lidar (PCL have been used to develop temperature climatologies for the stratosphere, mesosphere, and thermosphere using data from 1994 to 2013 (Rayleigh system and from 1999 to 2013 (vibrational Raman system. Temperature retrievals from Rayleigh-scattering lidar measurements have been performed using the methods by Hauchecorne and Chanin (1980; henceforth HC and Khanna et al. (2012. Argall and Sica (2007 used the HC method to compute a climatology of the PCL measurements from 1994 to 2004 for 35 to 110 km, while Iserhienrhien et al. (2013 applied the same technique from 1999 to 2007 for 10 to 35 km. Khanna et al. (2012 used the inversion technique to retrieve atmospheric temperature profiles and found that it had advantages over the HC method. This paper presents an extension of the PCL climatologies created by Argall and Sica (2007 and Iserhienrhien et al. (2013. Both the inversion and HC methods were used to form the Rayleigh climatology, while only the latter was adopted for the Raman climatology. Then, two different approaches were used to merge the climatologies from 10 to 110 km. Among four different functional identities, a trigonometric hyperbolic relation results in the best choice for merging temperature profiles between the Raman and Low level Rayleigh channels, with an estimated uncertainty of 0.9 K for merging temperatures. Also, error function produces best result with uncertainty of 0.7 K between the Low Level Rayleigh and High Level Rayleigh channels. The results show that the temperature climatologies produced by the HC method when using a seed pressure are comparable to the climatologies produced by the inversion method. The Rayleigh extended climatology is slightly warmer below 80 km and slightly colder above 80 km. There are no significant differences in temperature between the extended and the previous Raman channel climatologies

  3. Formation and Development of Diabatic Rossby Vortices in a 10-Year Climatology

    Science.gov (United States)

    2012-06-01

    DEVELOPMENT OF DIABATIC ROSSBY VORTICES IN A 10-YEAR CLIMATOLOGY by Nengwei “Tom” Shih June 2012 Thesis Advisor: Richard W. Moore Second...TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Formation and Development of Diabatic Rossby Vortices in a 10-Year Climatology 5...release; distribution is unlimited 12b. DISTRIBUTION CODE A 13. ABSTRACT (maximum 200 words) A diabatic Rossby vortex (DRV) is a short-scale

  4. Simulation of Sea Ice in FGOALS-g2: Climatology and Late 20th Century Changes

    Institute of Scientific and Technical Information of China (English)

    XU Shiming; SONG Mirong; LIU Jiping; WANG Bin; LI Lijuan; HUANG Wenyu; LIU Li

    2013-01-01

    Sea ice is an important component in the Earth's climate system.Coupled climate system models are indispensable tools for the study of sea ice,its internal processes,interaction with other components,and projection of future changes.This paper evaluates the simulation of sea ice by the Flexible Global Ocean-Atmosphere-Land System model Grid-point Version 2 (FGOALS-g2),in the fifth phase of the Coupled Model Inter-comparison Project (CMIP5),with a focus on historical experiments and late 20th century simulation.Through analysis,we find that FGOALS-g2 produces reasonable Arctic and Antarctic sea ice climatology and variability.Sea ice spatial distribution and seasonal change characteristics are well captured.The decrease of Arctic sea ice extent in the late 20th century is reproduced in simulations,although the decrease trend is lower compared with observations.Simulated Antarctic sea ice shows a reasonable distribution and seasonal cycle with high accordance to the amplitude of winter summer changes.Large improvement is achieved as compared with FGOALS-g1.0 in CMIP3.Diagnosis of atmospheric and oceanic forcing on sea ice reveals several shortcomings and major aspects to improve upon in the future:(1) ocean model improvements to remove the artificial island at the North Pole;(2) higher resolution of the atmosphere model for better simulation of important features such as,among others,the Icelandic Low and westerly wind over the Southern Ocean; and (3) ocean model improvements to accurately receive freshwater input from land,and higher resolution for resolving major water channels in the Canadian Arctic Archipelago.

  5. Romans-mass-driven flows on the D2-brane

    CERN Document Server

    Guarino, Adolfo; Varela, Oscar

    2016-01-01

    The addition of supersymmetric Chern-Simons terms to ${\\cal N}=8$ super-Yang-Mills theory in three-dimensions is expected to make the latter flow into infrared superconformal phases. We address this problem holographically by studying the effect of the Romans mass on the D2-brane near-horizon geometry. Working in a consistent, effective four-dimensional setting provided by $D=4$ ${\\cal N}=8$ supergravity with a dyonic $\\textrm{ISO(7)}$ gauging, we verify the existence of a rich web of supersymmetric domain walls triggered by the Romans mass that interpolate between the (four-dimensional description of the) D2-brane and various superconformal phases. We also construct domain walls for which both endpoints are superconformal. While most of our results are numerical, we provide analytic results for the $\\textrm{SU}(3)\\times \\textrm{U}(1)$-invariant flow into an ${\\cal N}=2$ conformal phase recently discovered.

  6. Romans-mass-driven flows on the D2-brane

    Energy Technology Data Exchange (ETDEWEB)

    Guarino, Adolfo [Nikhef Theory Group,Science Park 105, 1098 XG Amsterdam (Netherlands); Tarrío, Javier [Physique Théorique et Mathématique, Université Libre de Bruxellesand International Solvay Institutes,ULB-Campus Plaine CP231, B-1050 Brussels (Belgium); Varela, Oscar [Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut),Am Mühlenberg 1, D-14476 Potsdam (Germany); Department of Physics, Utah State University,Logan, UT 84322 (United States)

    2016-08-30

    The addition of supersymmetric Chern-Simons terms to N=8 super-Yang-Mills theory in three-dimensions is expected to make the latter flow into infrared superconformal phases. We address this problem holographically by studying the effect of the Romans mass on the D2-brane near-horizon geometry. Working in a consistent, effective four-dimensional setting provided by D=4N=8 supergravity with a dyonic ISO(7) gauging, we verify the existence of a rich web of supersymmetric domain walls triggered by the Romans mass that interpolate between the (four-dimensional description of the) D2-brane and various superconformal phases. We also construct domain walls for which both endpoints are superconformal. While most of our results are numerical, we provide analytic results for the SU(3)×U(1)-invariant flow into an N=2 conformal phase recently discovered.

  7. 3D-2D registration of cerebral angiograms based on vessel directions and intensity gradients

    Science.gov (United States)

    Mitrovic, Uroš; Špiclin, Žiga; Štern, Darko; Markelj, Primož; Likar, Boštjan; Miloševic, Zoran; Pernuš, Franjo

    2012-02-01

    Endovascular treatment of cerebral aneurysms and arteriovenous malformations (AVM) involves navigation of a catheter through the femoral artery and vascular system to the site of pathology. Intra-interventional navigation is done under the guidance of one or at most two two-dimensional (2D) X-ray fluoroscopic images or 2D digital subtracted angiograms (DSA). Due to the projective nature of 2D images, the interventionist needs to mentally reconstruct the position of the catheter in respect to the three-dimensional (3D) patient vasculature, which is not a trivial task. By 3D-2D registration of pre-interventional 3D images like CTA, MRA or 3D-DSA and intra-interventional 2D images, intra-interventional tools such as catheters can be visualized on the 3D model of patient vasculature, allowing easier and faster navigation. Such a navigation may consequently lead to the reduction of total ionizing dose and delivered contrast medium. In the past, development and evaluation of 3D-2D registration methods for endovascular treatments received considerable attention. The main drawback of these methods is that they have to be initialized rather close to the correct position as they mostly have a rather small capture range. In this paper, a novel registration method that has a higher capture range and success rate is proposed. The proposed method and a state-of-the-art method were tested and evaluated on synthetic and clinical 3D-2D image-pairs. The results on both databases indicate that although the proposed method was slightly less accurate, it significantly outperformed the state-of-the-art 3D-2D registration method in terms of robustness measured by capture range and success rate.

  8. A climatology of formation conditions for aerodynamic contrails

    Directory of Open Access Journals (Sweden)

    K. Gierens

    2013-11-01

    Full Text Available Aircraft at cruise levels can cause two kinds of contrails, the well known exhaust contrails and the less well-known aerodynamic contrails. While the possible climate impact of exhaust contrails has been studied for many years, research on aerodynamic contrails began only a few years ago and nothing is known about a possible contribution of these ice clouds to climate impact. In order to make progress in this respect, we first need a climatology of their formation conditions and this is given in the present paper. Aerodynamic contrails are defined here as line shaped ice clouds caused by aerodynamically triggered cooling over the wings of an aircraft in cruise which become visible immediately at the trailing edge of the wing or close to it. Effects at low altitudes like condensation to liquid droplets and their potential heterogeneous freezing are excluded from our definition. We study atmospheric conditions that allow formation of aerodynamic contrails. These conditions are stated and then applied to atmospheric data: first to a special case where an aerodynamic contrail was actually observed and then to a full year of global reanalysis data. We show where, when (seasonal variation, and how frequently (probability aerodynamic contrails can form, and how this relates to actual patterns of air traffic. We study the formation of persistent aerodynamic contrails as well. Furthermore, we check whether aerodynamic and exhaust contrails can coexist in the atmosphere. We show that visible aerodynamic contrails are possible only in an altitude range between roughly 540 and 250 hPa, and that the ambient temperature is the most important parameter, not the relative humidity. Finally, we argue that currently aerodynamic contrails have a much smaller climate effect than exhaust contrails, which may however change in future with more air traffic in the tropics.

  9. Mapping Atmospheric Moisture Climatologies across the Conterminous United States.

    Directory of Open Access Journals (Sweden)

    Christopher Daly

    Full Text Available Spatial climate datasets of 1981-2010 long-term mean monthly average dew point and minimum and maximum vapor pressure deficit were developed for the conterminous United States at 30-arcsec (~800m resolution. Interpolation of long-term averages (twelve monthly values per variable was performed using PRISM (Parameter-elevation Relationships on Independent Slopes Model. Surface stations available for analysis numbered only 4,000 for dew point and 3,500 for vapor pressure deficit, compared to 16,000 for previously-developed grids of 1981-2010 long-term mean monthly minimum and maximum temperature. Therefore, a form of Climatologically-Aided Interpolation (CAI was used, in which the 1981-2010 temperature grids were used as predictor grids. For each grid cell, PRISM calculated a local regression function between the interpolated climate variable and the predictor grid. Nearby stations entering the regression were assigned weights based on the physiographic similarity of the station to the grid cell that included the effects of distance, elevation, coastal proximity, vertical atmospheric layer, and topographic position. Interpolation uncertainties were estimated using cross-validation exercises. Given that CAI interpolation was used, a new method was developed to allow uncertainties in predictor grids to be accounted for in estimating the total interpolation error. Local land use/land cover properties had noticeable effects on the spatial patterns of atmospheric moisture content and deficit. An example of this was relatively high dew points and low vapor pressure deficits at stations located in or near irrigated fields. The new grids, in combination with existing temperature grids, enable the user to derive a full suite of atmospheric moisture variables, such as minimum and maximum relative humidity, vapor pressure, and dew point depression, with accompanying assumptions. All of these grids are available online at http://prism.oregonstate.edu, and

  10. Borehole climatology: a discussion based on contributions from climate modeling

    Directory of Open Access Journals (Sweden)

    J. F. González-Rouco

    2009-03-01

    Full Text Available Progress in understanding climate variability through the last millennium leans on simulation and reconstruction efforts. Exercises blending both approaches present a great potential for answering questions relevant both for the simulation and reconstruction of past climate, and depend on the specific peculiarities of proxies and methods involved in climate reconstructions, as well as on the realism and limitations of model simulations. This paper explores research specifically related to paleoclimate modeling and borehole climatology as a branch of climate reconstruction that has contributed significantly to our knowledge of the low frequency climate evolution during the last five centuries.

    The text flows around three main issues that group most of the interaction between model and geothermal efforts: the use of models as a validation tool for borehole climate reconstructions; comparison of geothermal information and model simulations as a means of either model validation or inference about past climate; and implications of the degree of realism on simulating subsurface climate on estimations of future climate change.

    The use of multi-centennial simulations as a surrogate reality for past climate suggests that within the simplified reality of climate models, methods and assumptions in borehole reconstructions deliver a consistent picture of past climate evolution at long time scales. Comparison of model simulations and borehole profiles indicate that borehole temperatures are responding to past external forcing and that more realism in the development of the soil model components in climate models is desirable. Such an improved degree of realism is important for the simulation of subsurface climate and air-ground interaction; results indicate it could also be crucial for simulating the adequate energy balance within climate change scenario experiments.

  11. Climatology of Aerosol Optical Properties in Southern Africa

    Science.gov (United States)

    Queface, Antonio J.; Piketh, Stuart J.; Eck, Thomas F.; Tsay, Si-Chee

    2011-01-01

    A thorough regionally dependent understanding of optical properties of aerosols and their spatial and temporal distribution is required before we can accurately evaluate aerosol effects in the climate system. Long term measurements of aerosol optical depth, Angstrom exponent and retrieved single scattering albedo and size distribution, were analyzed and compiled into an aerosol optical properties climatology for southern Africa. Monitoring of aerosol parameters have been made by the AERONET program since the middle of the last decade in southern Africa. This valuable information provided an opportunity for understanding how aerosols of different types influence the regional radiation budget. Two long term sites, Mongu in Zambia and Skukuza in South Africa formed the core sources of data in this study. Results show that seasonal variation of aerosol optical thicknesses at 500 nm in southern Africa are characterized by low seasonal multi-month mean values (0.11 to 0.17) from December to May, medium values (0.20 to 0.27) between June and August, and high to very high values (0.30 to 0.46) during September to November. The spatial distribution of aerosol loadings shows that the north has high magnitudes than the south in the biomass burning season and the opposite in none biomass burning season. From the present aerosol data, no long term discernable trends are observable in aerosol concentrations in this region. This study also reveals that biomass burning aerosols contribute the bulk of the aerosol loading in August-October. Therefore if biomass burning could be controlled, southern Africa will experience a significant reduction in total atmospheric aerosol loading. In addition to that, aerosol volume size distribution is characterized by low concentrations in the non biomass burning period and well balanced particle size contributions of both coarse and fine modes. In contrast high concentrations are characteristic of biomass burning period, combined with

  12. Lightning climatology in the Congo Basin: methodology and first results

    Science.gov (United States)

    Kigotsi, Jean; Soula, Serge; Georgis, Jean-François; Barthe, Christelle

    2016-04-01

    The global climatology of lightning issued from space observations (OTD and LIS) clearly showed the maximum of the thunderstorm activity is located in a large area of the Congo Basin, especially in the Democratic Republic of Congo (DRC). The first goal of the present study is to compare observations from the World Wide Lightning Location Network (WWLLN) from the Lightning Imaging Sensor (LIS) over a 9-year period (2005-2013) in this 2750 km × 2750 km area. The second goal is to analyse the lightning activity in terms of time and space variability. The detection efficiency (DE) of the WWLLN relative to LIS has increased between 2005 and 2013, typically from about 1.70 % to 5.90 %, in agreement with previous results for other regions of the world. The mean monthly flash rate describes an annual cycle with a maximum between November and March and a minimum between June and August, associated with the ICTZ migration but not exactly symmetrical on both sides of the equator. The diurnal evolution of the flash rate has a maximum between 1400 and 1700 UTC, depending on the reference year, in agreement with previous works in other regions of the world. The annual flash density shows a sharp maximum localized in eastern DRC regardless of the reference year and the period of the year. This annual maximum systematically located west of Kivu Lake corresponds to that previously identified by many authors as the worldwide maximum which Christian et al. (2013) falsely attributed to Rwanda. Another more extended region within the Congo Basin exhibits moderately large values, especially during the beginning of the period analyzed. A comparison of both patterns of lightning density from the WWLLN and from LIS allows to validate the representativeness of this world network and to restitute the total lightning activity in terms of lightning density and rate.

  13. Climatology of Aerosol Optical Properties in Southern Africa

    Science.gov (United States)

    Queface, Antonio J.; Piketh, Stuart J.; Eck, Thomas F.; Tsay, Si-Chee

    2011-01-01

    A thorough regionally dependent understanding of optical properties of aerosols and their spatial and temporal distribution is required before we can accurately evaluate aerosol effects in the climate system. Long term measurements of aerosol optical depth, Angstrom exponent and retrieved single scattering albedo and size distribution, were analyzed and compiled into an aerosol optical properties climatology for southern Africa. Monitoring of aerosol parameters have been made by the AERONET program since the middle of the last decade in southern Africa. This valuable information provided an opportunity for understanding how aerosols of different types influence the regional radiation budget. Two long term sites, Mongu in Zambia and Skukuza in South Africa formed the core sources of data in this study. Results show that seasonal variation of aerosol optical thicknesses at 500 nm in southern Africa are characterized by low seasonal multi-month mean values (0.11 to 0.17) from December to May, medium values (0.20 to 0.27) between June and August, and high to very high values (0.30 to 0.46) during September to November. The spatial distribution of aerosol loadings shows that the north has high magnitudes than the south in the biomass burning season and the opposite in none biomass burning season. From the present aerosol data, no long term discernable trends are observable in aerosol concentrations in this region. This study also reveals that biomass burning aerosols contribute the bulk of the aerosol loading in August-October. Therefore if biomass burning could be controlled, southern Africa will experience a significant reduction in total atmospheric aerosol loading. In addition to that, aerosol volume size distribution is characterized by low concentrations in the non biomass burning period and well balanced particle size contributions of both coarse and fine modes. In contrast high concentrations are characteristic of biomass burning period, combined with

  14. A climatology of potential severe convective environments across South Africa

    Science.gov (United States)

    Blamey, R. C.; Middleton, C.; Lennard, C.; Reason, C. J. C.

    2017-09-01

    Severe thunderstorms pose a considerable risk to society and the economy of South Africa during the austral summer months (October-March). Yet, the frequency and distribution of such severe storms is poorly understood, which partly stems out of an inadequate observation network. Given the lack of observations, alternative methods have focused on the relationship between severe storms and their associated environments. One such approach is to use a combination of covariant discriminants, derived from gridded datasets, as a probabilistic proxy for the development of severe storms. These covariates describe some key ingredient for severe convective storm development, such as the presence of instability. Using a combination of convective available potential energy and deep-layer vertical shear from Climate Forecast System Reanalysis, this study establishes a climatology of potential severe convective environments across South Africa for the period 1979-2010. Results indicate that early austral summer months are most likely associated with conditions that are conducive to the development of severe storms over the interior of South Africa. The east coast of the country is a hotspot for potential severe convective environments throughout the summer months. This is likely due to the close proximity of the Agulhas Current, which produces high latent heat fluxes and acts as a key moisture source. No obvious relationship is established between the frequency of potential severe convective environments and the main large-scale modes of variability in the Southern Hemisphere, such as ENSO. This implies that several factors, possibly more localised, may modulate the spatial and temporal frequency of severe thunderstorms across the region.

  15. Understanding the Rainfall Daily Climatology of Northwestern Mexico

    Science.gov (United States)

    Brito-Castillo, L.

    2007-05-01

    Maximum monthly precipitation (MMP) over northwestern Mexico is not concurrent because it occurs in different months from July through September. However, instead of occurring progressively from one month to the next as latitude increases, as it might be logic since rains move progressively from south to north as monsoon develops, MMP occurs in July in latitudes of Jalisco state, then MMP shifts to August more to the north in latitudes of Nayarit state and along the eastern coast of the Gulf of California, then it occurs in July in higher latitudes through the main axis of the Sierra Madre Occidental (SMO), and finally MMP shifts to September to the west in the California Peninsula. The maximum monthly streamflow occurs in a similar pattern as MMP does but one month later. When daily rainfall climatology of the region is calculated, i.e. the long-term mean per day from stations with more than 20 years of data between 1940 and 2004, it is possible to understand why the behavior of MMP occurs in a July-August-July pattern from south to north. Preliminary results indicate that at latitudes of Nayarit state normal frequent storms with abundant rains develop at the end of July and through the August. These rains sum to the rains that move from the south to the north, as monsoon develops increasing the volume of precipitations at those latitudes in August. To the east crossing the SMO through northwestern Zacatecas state maximum volume of precipitations also is observed in August. However, in higher latitudes it is not observed any increment of rains in August and consequently maximum volume of precipitations occurs in July. To understand the dynamics of the rains at the latitudes of Nayarit state it results necessary to investigate the source of these local rains and explain why the increase of precipitations in August is limited at those latitudes.

  16. An Emerging Global Aerosol Climatology from the MODIS Satellite Sensors

    Science.gov (United States)

    Remer, Lorraine A.; Kleidman, Richard G.; Levy, Robert C.; Kaufman, Yoram J.; Tanre, Didier; Mattoo, Shana; Martins, J. Vandelei; Ichoku, Charles; Koren, Ilan; Hongbin, Yu; hide

    2008-01-01

    The recently released Collection 5 MODIS aerosol products provide a consistent record of the Earth's aerosol system. Comparison with ground-based AERONET observations of aerosol optical depth (AOD) we find that Collection 5 MODIS aerosol products estimate AOD to within expected accuracy more than 60% of the time over ocean and more than 72% of the time over land. This is similar to previous results for ocean, and better than the previous results for land. However, the new Collection introduces a 0.01 5 offset between the Terra and Aqua global mean AOD over ocean, where none existed previously. Aqua conforms to previous values and expectations while Terra is high. The cause of the offset is unknown, but changes to calibration are a possible explanation. We focus the climatological analysis on the better understood Aqua retrievals. We find that global mean AOD at 550 nm over oceans is 0.13 and over land 0.19. AOD in situations with 80% cloud fraction are twice the global mean values, although such situations occur only 2% of the time over ocean and less than 1% of the time over land. There is no drastic change in aerosol particle size associated with these very cloudy situations. Regionally, aerosol amounts vary from polluted areas such as East Asia and India, to the cleanest regions such as Australia and the northern continents. In almost all oceans fine mode aerosol dominates over dust, except in the tropical Atlantic downwind of the Sahara and in some months the Arabian Sea.

  17. A climatological study of rural surface ozone in central Greece

    Directory of Open Access Journals (Sweden)

    P. D. Kalabokas

    2004-01-01

    Full Text Available Recent studies show that surface ozone levels at rural sites in Greece are generally high when compared with rural ozone measurements at northern European sites. The area of SE Europe, including Greece, is not very well monitored regarding rural ozone in comparison to central and northern Europe. In order to have the best possible picture of the rural surface ozone climatology in the area, based on the available data-sets of long-term continuous monitoring stations, the 10-year measurement records (1987-1996 of the Athens peripheral station of Liossia, (12 km N of the city center and the urban background station of Geoponiki (3 km W as well as the 4-year record (1996-1999 of the rural station of Aliartos (100 km NW of Athens, are analyzed in this paper. The data for Liossia and Geoponiki stations are screened for cases of strong airflow from rural areas (N-NE winds stronger than 5 m/s. The variation characteristics of the average rural ozone afternoon levels (12:00-18:00, with the best vertical atmospheric mixing, are mainly examined since these measurements are expected to be representative of the broader area. In all three stations there is a characteristic seasonal variation of rural ozone concentrations with lowest winter afternoon values at about 50 μg/m3 in December-January and average summer afternoon values at about 120 μg/m3 in July-August, indicating that high summer values are observed all over the area. The rural summer afternoon ozone values are very well correlated between the three stations, implying spatial homogeneity all over the area but also temporal homogeneity, since during the 13-year period 1987-1999 the rural afternoon ozone levels remained almost constant around the value of 120 μg/m3.

  18. Vibrational line shapes in the amalgamated limit: (para-D2)x(ortho-D2)1-x mixed crystals

    Science.gov (United States)

    de Kinder, J.; Bouwen, A.; Schoemaker, D.; Boukahil, A.; Huber, D. L.

    1994-05-01

    The D2 vibrons have been studied by high-resolution Raman scattering in mixed crystals of (p-D2)x(o-D2)1-x. The o-D2 and p-D2 vibrational transitions are found to overlap. Line shapes calculated by the coherent potential approximation are in good qualitative agreement with the experimental data. The linewidth of the o-D2 transition is much larger than the linewidth of the p-H2 transition in (o-H2)x(p-H2)1-x mixed crystals with comparable J=1 concentrations. Possible explanations for this difference are discussed.

  19. First look at the NOAA Aircraft-based Tropospheric Ozone Climatology

    Science.gov (United States)

    Leonard, M.; Petropavlovskikh, I. V.; McClure-Begley, A.; Lin, M.; Tarasick, D.; Johnson, B. J.; Oltmans, S. J.

    2015-12-01

    The Global Greenhouse Gas Reference Network's aircraft program has operated since the 1990s as part of the NOAA Global Monitoring Division network to capture spatial and temporal variability in greenhouse tracers (i.e. CO2, CO, N2O, methane, SF6, halo- and hydro-carbons). Since 2005 the suite of airborne measurements also includes ozone, humidity and temperature profiling through the troposphere (up to 8 km). Light commercial aircraft are equipped with modified 2B Technology ozone monitors (Model 205DB), incorporate temperature and humidity probes, and include global positioning system instrumentation. The dataset was analyzed for tropospheric ozone variability at five continental US stations. As site locations within the Tropospheric Aircraft Ozone Measurement Program have flights only once (four times at one site) a month and begun a decade ago, this raises the question of whether this sampling frequency allows the derivation of an accurate vertical climatology of ozone values. We interpret the representativeness of the vertical and seasonal ozone distribution from aircraft measurements using multi-decadal hindcast simulations conducted with the GFDL AM3 chemistry-climate model. When available, climatology derived from co-located ozone-sonde data will be used for comparisons. The results of the comparisons are analyzed to establish altitude ranges in the troposphere where the aircraft climatology would be deemed to be the most representative. Aircraft-based climatologies are tested from two approaches: comparing the aircraft-based climatology to the daily sampled model and to the subset of model data with matching aircraft dates. Whenever the model and aircraft climatologies show significant seasonal differences, further information is gathered from a seasonal Gaussian distribution plot. We will report on the minimum frequency in flights that can provide adequate climatological representation of seasonal and vertical variability in tropospheric ozone.

  20. EuCARD-Del-D2.2.2

    CERN Document Server

    Chaudron, M; Szeberenyi, A

    2013-01-01

    This document presents the terms of use and dissemination of the foreground arising from the Project and which the Project partners own, in accordance with their interests. The document gives a cumulative overview of the Project’s dissemination and education (planned and undertaken) activities, introduces information about the contacts established with local audiences (mostly in Partners’ countries), reports fulfilment of the dissemination work plan and gives some information on patents registered and exploitable foreground generated within the Project. This document is part of the Final Project Report (D1.4).

  1. 单群2D2n(2)的拟刻画%Quasirecognition of the Simple Group 2 D2n (2)

    Institute of Scientific and Technical Information of China (English)

    李立莉

    2015-01-01

    Let G be finite group such that M(G) = M(2 D2n (2)) where 2n -1 prime .Then G has a nor‐mal subgroup isomorphic to 2 D2n (2) .Especially ,if | G | = |2 D2n (2)| ,then G ≌ 2 D2n (2) .%设 G为有限群,且满足 M(G)= M(2 D2n (2)),其中2n -1为素数。则 G必有正规子群同构于2 D2n (2)。特别地,若|G|=|2 D2n (2)|,则G ≌2 D2n (2)。

  2. Crossed beam studies of O/-/ + D2 yields OD/-/ + D

    Science.gov (United States)

    Johnson, S. G.; Kremer, L. N.; Metral, C. J.; Cross, R. J., Jr.

    1978-01-01

    Using the crossed-beam machine EVA measurements have been conducted of the product angular and energy distributions of the reaction O(-) + D2 yields OD(-) + D in the relative energy range of 1.2-4.7 eV (5.7-23.1 eV LAB). Below 2.5 eV the product distribution is centered about the center of mass, indicating a long-lived complex. Above 2.5 eV the distribution slowly moves forward. Most of the available energy goes into internal energy of the products.

  3. Anomeric and tautomeric equilibria in D-2-glucosamine Schiff bases

    Science.gov (United States)

    Kołodziej, B.; Grech, E.; Schilf, W.; Kamieński, B.; Makowski, M.; Rozwadowski, Z.; Dziembowska, T.

    2007-11-01

    The structure of some glucosamine Schiff bases has been studied by means of ab initio RHF and DFT calculation and CP/MAS 13C and 15N NMR measurements. The anomeric and tautomeric equilibria in a DMSO solution have been studied by 1H, 13C and 15N NMR spectroscopy. The anomeric composition of D-2-glucosamine Schiff bases in the solid state and in DMSO solution has been shown to depends on the tautomeric form of Schiff bases and electronic properties of substituents on the aromatic ring.

  4. Dopamine D2 receptor-mediated Akt/PKB signalling: initiation by the D2S receptor and role in quinpirole-induced behavioural activation.

    Science.gov (United States)

    Chen, Han-Ting; Ruan, Nan-Yu; Chen, Jin-Chung; Lin, Tzu-Yung

    2012-09-24

    The short and long isoforms of the dopamine D2 receptor (D2S and D2L respectively) are highly expressed in the striatum. Functional D2 receptors activate an intracellular signalling pathway that includes a cAMP-independent route involving Akt/GSK3 (glycogen synthase kinase 3). To investigate the Akt/GSK3 response to the seldom-studied D2S receptor, we established a rat D2S receptor-expressing cell line [HEK (human embryonic kidney)-293/rD2S]. We found that in HEK-293/rD2S cells, the D2/D3 agonists bromocriptine and quinpirole significantly induced Akt and GSK3 phosphorylation, as well as ERK1/2 (extracellular-signal-regulated kinase 1/2) activation. The D2S receptor-induced Akt signals were profoundly inhibited by the internalization blockers monodansyl cadaverine and concanavalin A. Activation of the D2S receptor in HEK-293/rD2S cells appeared to trigger Akt/phospho-Akt translocation to the cell membrane. In addition to our cell culture experiments, we studied D2 receptor-dependent Akt in vivo by systemic administration of the D2/D3 agonist quinpirole. The results show that quinpirole evoked Akt-Ser473 phosphorylation in the ventral striatum. Furthermore, intra-accumbens administration of wortmannin, a PI3K (phosphoinositide 3-kinase) inhibitor, significantly suppressed the quinpirole-evoked behavioural activation. Overall, we demonstrate that activation of the dopamine D2S receptor stimulates Akt/GSK3 signalling. In addition, in vivo Akt activity in the ventral striatum appears to play an important role in systemic D2/D3 agonist-induced behavioural activation.

  5. Dopamine D2 receptor-mediated Akt/PKB signalling: initiation by the D2S receptor and role in quinpirole-induced behavioural activation

    Directory of Open Access Journals (Sweden)

    Jin‑Chung Chen

    2012-09-01

    Full Text Available The short and long isoforms of the dopamine D2 receptor (D2S and D2L respectively are highly expressed in the striatum. Functional D2 receptors activate an intracellular signalling pathway that includes a cAMP-independent route involving Akt/GSK3 (glycogen synthase kinase 3. To investigate the Akt/GSK3 response to the seldom-studied D2S receptor, we established a rat D2S receptor-expressing cell line [HEK (human embryonic kidney-293/rD2S]. We found that in HEK-293/rD2S cells, the D2/D3 agonists bromocriptine and quinpirole significantly induced Akt and GSK3 phosphorylation, as well as ERK1/2 (extracellular-signal-regulated kinase 1/2 activation. The D2S receptor-induced Akt signals were profoundly inhibited by the internalization blockers monodansyl cadaverine and concanavalin A. Activation of the D2S receptor in HEK-293/rD2S cells appeared to trigger Akt/phospho-Akt translocation to the cell membrane. In addition to our cell culture experiments, we studied D2 receptor-dependent Akt in vivo by systemic administration of the D2/D3 agonist quinpirole. The results show that quinpirole evoked Akt-Ser473 phosphorylation in the ventral striatum. Furthermore, intra-accumbens administration of wortmannin, a PI3K (phosphoinositide 3-kinase inhibitor, significantly suppressed the quinpirole-evoked behavioural activation. Overall, we demonstrate that activation of the dopamine D2S receptor stimulates Akt/GSK3 signalling. In addition, in vivo Akt activity in the ventral striatum appears to play an important role in systemic D2/D3 agonist-induced behavioural activation.

  6. The Climatology of Taiwan extreme rainfall events and the attributions

    Science.gov (United States)

    Su, S. H.; Kuo, H. C.; Chen, Y. H.; Chu, J. L.; Lin, L. Y.

    2015-12-01

    Taiwan is located in the East-Asian monsoon region with average 2,500mm annual precipitation. Most significant Meteorological disasters are related to extreme precipitation which is associated with a complex terrain. Therefore, the long-term trends or climate variations in precipitation due to climate change are our major concern. We studied the climatology of extreme rainfall (ER, 95thpercentile) events in Taiwan using hourly precipitation data form 21 surface stations during 1960-2014. ER contributes about 40% of the total rain amount. It was found that approximately 68% of ER is related to typhoon (TY) and 22% associated with the Mei-Yu (MY) frontal system. The total ER amount annual variation is strongly related to TY, with correlation coefficient of 0.89 for rainfall amount and 0.86 for frequency. There is a significant increasing trend of TY-ER in past 55 years, but also has large variations over the annual and decadal time scales. The inter-annual variation of astounding extreme rainfall (AER, 99.9thpercentile) is increased significantly, especially in the past 15 years. It implies that the increasing of AER rainfall amount majorly caused by the increasing of frequency instead of average rain intensity of TY-AER. The MY-ER events are also highly correlated with the frontal system. The correlation is 0.84 for the rainfall amount and 0.83 of the frequency with the frontal days. There are also strong inter-annual variations of MY-ER, but the long-term trends are not as significant as TY-ER. The variation of frontal system number is another parameter may impact the MY-ER. The observational frontal system numbers had positive correlation with the MY-ER. The attribution of Taiwan TY-ER changes was debated in the research community. In general, the public acceptance of Taiwan extreme precipitation events is affected by multi-scale systems. According to observational data, the increasing of TY-ER amount is 37 % (48% )in Taiwan and some resent studies (Wang et al

  7. The European 2015 drought from a climatological perspective

    Science.gov (United States)

    Ionita, Monica; Tallaksen, Lena M.; Kingston, Daniel G.; Stagge, James H.; Laaha, Gregor; Van Lanen, Henny A. J.; Scholz, Patrick; Chelcea, Silvia M.; Haslinger, Klaus

    2017-03-01

    The summer drought of 2015 affected a large portion of continental Europe and was one of the most severe droughts in the region since summer 2003. The summer of 2015 was characterized by exceptionally high temperatures in many parts of central and eastern Europe, with daily maximum temperatures 2 °C higher than the seasonal mean (1971-2000) over most of western Europe, and more than 3 °C higher in the east. It was the hottest and climatologically driest summer over the 1950-2015 study period for an area stretching from the eastern Czech Republic to Ukraine. For Europe, as a whole, it is among the six hottest and driest summers since 1950. High evapotranspiration rates combined with a lack of precipitation affected soil moisture and vegetation and led to record low river flows in several major rivers, even beyond the drought-hit region. The 2015 drought developed rather rapidly over the Iberian Peninsula, France, southern Benelux and central Germany in May and reached peak intensity and spatial extent by August, affecting especially the eastern part of Europe. Over the summer period, there were four heat wave episodes, all associated with persistent blocking events. Upper-level atmospheric circulation over Europe was characterized by positive 500 hPa geopotential height anomalies flanked by a large negative anomaly to the north and west (i.e., over the central North Atlantic Ocean extending to northern Fennoscandia) and another center of positive geopotential height anomalies over Greenland and northern Canada. Simultaneously, the summer sea surface temperatures (SSTs) were characterized by large negative anomalies in the central North Atlantic Ocean and large positive anomalies in the Mediterranean basin. Composite analysis shows that the western Mediterranean SST is strongly related to the occurrence of dry and hot summers over the last 66 years (especially over the eastern part of Europe). The lagged relationship between the Mediterranean SST and summer drought

  8. A Climatological Investigation of the Activity of Summer Subtropical Vortices

    Institute of Scientific and Technical Information of China (English)

    LUO Zhexian; DAI Kan

    2008-01-01

    By applying a new vortex detection method to the ECMWF 40-yr reanalysis (ERA40) data from 1985 to 2002, the climatology of summer vortices has been investigated in five subtropical regions, i.e., the northwestern Pacific, northeastern Pacific, northwestern Atlantic, northeastern Atlantic, and Australia-South Pacific, followed by validation with NCEP/NCAR reanalysis data. Results are as follows: (1) The spatial distributions of ERA40 vortex activities (VAC) were well consistent with those of NCEP/NCAR reanalysis (NRA) results in all regions, especially in northwestern Pacific. (2) Because of different model resolutions, both the number and intensity of vortices obtained from NRA were significantly weaker thanERA40's. (3) Vortices mainly cruised in coasts and the adjacent seas, from where to the land or the open sea vortex activities were gradually decreased. (4) There were two active centers in the northwestern Pacific:one was located in South China Sea and the other, as the largest center of the five regions, spread from the east side of the Philippines to Japan. (5) Over the northwestern Atlantic, most vortices occurred in Panama and its west-side offshore. (6) The spatial distributions of vortices were alike between the northeastern Pacific and northeastern Atlantic, both spreading from coasts to the west-side sea at 5°-20°N. (7) In the Anstralia-South Pacific, vortices were not as active as those in the other four regions, and mostly took place in the equator-side of near ocean areas. (8) Except the northwestern Pacific and northwestern Atlantic, the VAC interannual variations in the other three regions were different between ERA40 and NRA data. (9)In the northwestern Pacific and northwestern Atlantic, the VAC interannual variation could be separated to several distinct stages. (10) Since the mid 1980s, mean vortex intensity was getting increased in the northwestern Pacific, which was most significant in the subtropical areas on a global basis. In the western

  9. Nature and climatology of Pfänderwind

    Directory of Open Access Journals (Sweden)

    Alexander Gohm

    2015-04-01

    Full Text Available The characteristics and climatology of Pfänderwind, a largely unknown downslope windstorm near the town of Bregenz (Austria at the entrance of the Rhine Valley, are investigated based on an eleven-year dataset of weather station observations and ERA-Interim reanalyses. The goal is to clarify the inconsistency in the definition of this phenomenon, to illuminate its dynamics, and to quantify its frequency of occurrence. It is shown that Pfänderwind has similarities to foehn but does occur for different synoptic-scale conditions. Moreover, two types of Pfänderwind have to be distinguished: Type 1, or classical Pfänderwind, is associated with easterly to northeasterly large-scale flow that crosses the Pfänder mountain range, descends in a foehn-like manner and causes moderate to strong winds in the town of Bregenz and its vicinity. The temperature anomaly induced at the surface by adiabatic warming is small as a result of weak low-level stability. Type-1 events occur on average 12 times per year, preferentially in spring, and most frequently between the afternoon and midnight. Type 2, or southeast Pfänderwind, is associated with westerly to southwesterly ambient winds near the main Alpine crest level. The Rhine valley is filled with cold air and in most cases south foehn is not present. However, the synoptic and meso-scale pressure gradient favours southerly ageostrophic flow in the Rhine Valley especially near the top of the cold-air pool. This flow passes the Gebhardsberg, the southwestern extension of the Pfänder mountain range, descends on its leeward side and causes strong foehn-like warming at the surface. However, southerly to southeasterly near-surface winds at Bregenz are rather weak. Type-2 events occur on average 40 times per year, most frequently between the evening and the early morning, and exhibit a weak seasonal dependence. More than half of all type-1 and type-2 events last only one or two hours.

  10. Multivariate Analysis of Multi-tracer and Climatological Data in an Urbanizing, Drought-impacted Watershed

    Science.gov (United States)

    Creech, L. T.; Donahoe, R. J.

    2009-12-01

    This paper documents water quality conditions of the Lake Tuscaloosa, Alabama water-supply reservoir and its watershed under two end-members of hydrologic and climatic variability. These data afford the opportunity to view water quality in the context of both land use and drought, facilitating the development of coupled hydrologic and water-quality forecast models to guide watershed management decisions. This study demonstrates that even the region’s normal 10-year drought cycle holds the capacity to significantly impact water quality and should be incorporated into watershed models and decision-making. To accomplish the goals of this project, a multi-tracer approach has been adopted to assess solute sources and water-quality impairments induced by land use. The biogeochemical tracers include: Major- and minor-ions, trace metals, nutrient speciation and stable-isotope tracers at natural abundance levels. These tracers are also vital to understand the role of climate variability in the context of a heterogeneous landscape. Eight seasonal sampling events across 23 sample locations and two water years yield 184 discrete water-quality samples representative of a range of landscape variability and climatological conditions. Each sample was analyzed for 27 solute species and relevant indicators of water quality. Climatological data was obtained from public repositories (NCDC, USDA); hydrologic data from stream and precipitation gages within the watershed (USGS). Multivariate statistics are used to facilitate the numerical analysis and interpretation of the resulting data. Measurements of nitrogen speciation were collected to document patterns of nutrient loading and nitrogen cycling. These data are augmented by the analysis of nitrogen and oxygen isotopes of nitrate. These data clarify the extent to which nitrogen is being loaded in the non-growing season as well as the capacity of the lake to assimilate nutrients. Under drought conditions the lake becomes nitrogen

  11. MAC-v1: A new global aerosol climatology for climate studies

    Science.gov (United States)

    Kinne, Stefan; O'Donnel, Declan; Stier, Philip; Kloster, Silvia; Zhang, Kai; Schmidt, Hauke; Rast, Sebastian; Giorgetta, Marco; Eck, Tom F.; Stevens, Bjorn

    2013-12-01

    The Max-Planck-Institute Aerosol Climatology version 1 (MAC-v1) is introduced. It describes the optical properties of tropospheric aerosols on monthly timescales and with global coverage at a spatial resolution of 1° in latitude and longitude. By providing aerosol radiative properties for any wavelength of the solar (or shortwave) and of the terrestrial (or longwave) radiation spectrum, as needed in radiative transfer applications, this MAC-v1 data set lends itself to simplified and computationally efficient representations of tropospheric aerosol in climate studies. Estimates of aerosol radiative properties are provided for both total and anthropogenic aerosol in annual time steps from preindustrial times (i.e., starting with year 1860) well into the future (until the year 2100). Central to the aerosol climatology is the merging of monthly statistics of aerosol optical properties for current (year 2000) conditions. Hereby locally sparse but trusted high-quality data by ground-based sun-photometer networks are merged onto complete background maps defined by central data from global modeling with complex aerosol modules. This merging yields 0.13 for the global annual midvisible aerosol optical depth (AOD), with 0.07 attributed to aerosol sizes larger than 1 µm in diameter and 0.06 of attributed to aerosol sizes smaller than 1 µm in diameter. Hereby larger particles are less absorbing with a single scattering albedo (SSA) of 0.98 compared to 0.93 for smaller sizes. Simulation results of a global model are applied to prescribe the vertical distribution and to estimate anthropogenic contributions to the smaller size AOD as a function of time, with a 0.037 value for current conditions. In a demonstration application, the associated aerosol direct radiative effects are determined. For current conditions, total aerosol is estimated to reduce the combined shortwave and longwave net-flux balance at the top of the atmosphere by about -1.6 W/m2 from which -0.5 W/m2 (with

  12. Climatología urbana por modificación antropogénica. Alteración del balance de energía natural / Urban climatology by anthropogenic modification. Alteration of the natural energy balance

    Directory of Open Access Journals (Sweden)

    Fuentes Pérez, Carlos Alberto

    2015-09-01

    Full Text Available La investigación valora el análisis climático histórico para establecer la temperatura y humedad relativa media, en contraste con la climatología urbana por modificación antropogénica estudio de caso, y su contribución de consigna fijado para invierno y verano que son las estaciones críticas. El procedimiento metodológico a implementar, apoya a los planificadores urbanos a no tener que participar científicamente para evaluar el emplazamiento térmico de sus proyectos y por lo tanto se puede acelerar el proceso de diseño sin comprometer el énfasis en el contexto urbano sustentable. Con base a los resultados se establecen las islas de calor urbano y su huella térmica en el hábitat. El objetivo de la presente investigación es determinar la climatología urbana por modificación antropogénica y su alteración a la calidad del hábitat en Tampico, México. The research assesses the historical climate analysis to determine the average temperature and relative humidity, in contrast to urban anthropogenic weather modification case study, and their contribution setpoint set for winter and summer are the season’s criticism. The methodology to implement, procedure supports urban planners will not have to participate to scientifically evaluate the thermal construction projects and therefore can accelerate the design process without compromising the emphasis on sustainable urban context. Based on the results of urban heat islands and thermal footprint habitat established. The objective of this research is to determine the urban climate by anthropogenic modification and alteration of habitat quality in Tampico, Mexico.

  13. A new multi-parametric climatological approach to the study of the earthquake preparatory phase: the 2016 Amatrice-Norcia (Central Italy) seismic sequence

    Science.gov (United States)

    Piscini, Alessandro; De Santis, Angelo; Marchetti, Dedalo; Cianchini, Gianfranco

    2017-04-01

    Based on observations prior to earthquakes, recent theoretical considerations suggest that some geophysical quantities reveal abnormal changes that anticipate moderate and strong earthquakes, within a defined spatial area (the so-called Dobrovolsky area) according to a Lithosphere-Atmosphere-Ionosphere coupling (LAIC) model. One of the possible pre-earthquake effects could be the appearance of some climatological anomalies in the epicentral region, weeks/months before the major earthquakes. An ESA-funded project, SAFE (Swarm for Earthquake study) was dedicated to investigate the LAIC from ground to satellite. In this work, the period of two months preceding the Amatrice-Norcia (Central Italy) earthquake sequence that started on 24 August 2016 with an M6 earthquake, and some months later produced other two major shocks, i.e. an M5.9 on 26 October and then an M6.5 on 30 October, was analyzed in terms of some climatological parameters. In particular, starting from a date preceding of about two months the first major shock, we applied a new approach based on the comparison of the thirty-seven year time series at the same seasonal time of three land/atmospheric parameters, i.e. skin temperature (skt), total column water vapour (tcwv) and total column of ozone (tco3), collected from European Center Medium Weather Forecast (ECMWF), and the year in which the earthquake sequence occurred. The originality of the method stands in the way the complete time series is reduced, where also the possible effect of global warming is properly removed. A confutation/confirmation analysis was undertaken where these parameters were successfully analyzed in the same months but considering two seismically "calm" years, when significant seismicity was not present, in order to validate the technique. We also extended the analysis to all available years to construct a confusion matrix comparing the climatological anomalies with the real seismicity. This latter analysis has confirmed the

  14. Precipitation climatology over India: validation with observations and reanalysis datasets and spatial trends

    Science.gov (United States)

    Kishore, P.; Jyothi, S.; Basha, Ghouse; Rao, S. V. B.; Rajeevan, M.; Velicogna, Isabella; Sutterley, Tyler C.

    2016-01-01

    Changing rainfall patterns have significant effect on water resources, agriculture output in many countries, especially the country like India where the economy depends on rain-fed agriculture. Rainfall over India has large spatial as well as temporal variability. To understand the variability in rainfall, spatial-temporal analyses of rainfall have been studied by using 107 (1901-2007) years of daily gridded India Meteorological Department (IMD) rainfall datasets. Further, the validation of IMD precipitation data is carried out with different observational and different reanalysis datasets during the period from 1989 to 2007. The Global Precipitation Climatology Project data shows similar features as that of IMD with high degree of comparison, whereas Asian Precipitation-Highly-Resolved Observational Data Integration Towards Evaluation data show similar features but with large differences, especially over northwest, west coast and western Himalayas. Spatially, large deviation is observed in the interior peninsula during the monsoon season with National Aeronautics Space Administration-Modern Era Retrospective-analysis for Research and Applications (NASA-MERRA), pre-monsoon with Japanese 25 years Re Analysis (JRA-25), and post-monsoon with climate forecast system reanalysis (CFSR) reanalysis datasets. Among the reanalysis datasets, European Centre for Medium-Range Weather Forecasts Interim Re-Analysis (ERA-Interim) shows good comparison followed by CFSR, NASA-MERRA, and JRA-25. Further, for the first time, with high resolution and long-term IMD data, the spatial distribution of trends is estimated using robust regression analysis technique on the annual and seasonal rainfall data with respect to different regions of India. Significant positive and negative trends are noticed in the whole time series of data during the monsoon season. The northeast and west coast of the Indian region shows significant positive trends and negative trends over western Himalayas and

  15. Interstellar detection of c-C3D2

    CERN Document Server

    Spezzano, S; Schilke, P; Caselli, P; Menten, K M; McCarthy, M C; Bizzocchi, L; Trevino-Morales, S P; Aikawa, Y; Schlemmer, S

    2013-01-01

    We report the first interstellar detection of c-C3D2. The doubly deuterated cyclopropenylidene, a carbene, has been detected toward the starless cores TMC- 1C and L1544 using the IRAM 30m telescope. The J(Ka,Kc) = 3(0,3)-2(1,2), 3(1,3)-2(0,2), and 2(2,1)-1(1,0) transitions of this species have been observed at 3 mm in both sources. The expected 1:2 intensity ratio has been found in the 3(0,3)-2(1,2) and 3(1,3)-2(0,2) lines, belonging to the para and ortho species respectively. We also observed lines of the main species, c-C3H2, the singly deuterated c-C3HD, and the species with one 13C off of the principal axis of the molecule, c-H13CC2H. The lines of c-C3D2 have been observed with high signal to noise ratio, better than 7.5 sigma in TMC-1C and 9 sigma in L1544. The abundance of doubly deuterated cyclopropenylidene with respect to the normal species is found to be (0.4 - 0.8)% in TMC-1C and (1.2 - 2.1)% in L1544. The deuteration of this small hydrocarbon ring is analysed with a comprehensive gas-grain model, ...

  16. A new global interior ocean mapped climatology: the 1° × 1° GLODAP version 2

    Science.gov (United States)

    Lauvset, Siv K.; Key, Robert M.; Olsen, Are; van Heuven, Steven; Velo, Anton; Lin, Xiaohua; Schirnick, Carsten; Kozyr, Alex; Tanhua, Toste; Hoppema, Mario; Jutterström, Sara; Steinfeldt, Reiner; Jeansson, Emil; Ishii, Masao; Perez, Fiz F.; Suzuki, Toru; Watelet, Sylvain

    2016-08-01

    We present a mapped climatology (GLODAPv2.2016b) of ocean biogeochemical variables based on the new GLODAP version 2 data product (Olsen et al., 2016; Key et al., 2015), which covers all ocean basins over the years 1972 to 2013. The quality-controlled and internally consistent GLODAPv2 was used to create global 1° × 1° mapped climatologies of salinity, temperature, oxygen, nitrate, phosphate, silicate, total dissolved inorganic carbon (TCO2), total alkalinity (TAlk), pH, and CaCO3 saturation states using the Data-Interpolating Variational Analysis (DIVA) mapping method. Improving on maps based on an earlier but similar dataset, GLODAPv1.1, this climatology also covers the Arctic Ocean. Climatologies were created for 33 standard depth surfaces. The conceivably confounding temporal trends in TCO2 and pH due to anthropogenic influence were removed prior to mapping by normalizing these data to the year 2002 using first-order calculations of anthropogenic carbon accumulation rates. We additionally provide maps of accumulated anthropogenic carbon in the year 2002 and of preindustrial TCO2. For all parameters, all data from the full 1972-2013 period were used, including data that did not receive full secondary quality control. The GLODAPv2.2016b global 1° × 1° mapped climatologies, including error fields and ancillary information, are available at the GLODAPv2 web page at the Carbon Dioxide Information Analysis Center (CDIAC; doi:10.3334/CDIAC/OTG.NDP093_GLODAPv2).

  17. 3D-2D Deformable Image Registration Using Feature-Based Nonuniform Meshes.

    Science.gov (United States)

    Zhong, Zichun; Guo, Xiaohu; Cai, Yiqi; Yang, Yin; Wang, Jing; Jia, Xun; Mao, Weihua

    2016-01-01

    By using prior information of planning CT images and feature-based nonuniform meshes, this paper demonstrates that volumetric images can be efficiently registered with a very small portion of 2D projection images of a Cone-Beam Computed Tomography (CBCT) scan. After a density field is computed based on the extracted feature edges from planning CT images, nonuniform tetrahedral meshes will be automatically generated to better characterize the image features according to the density field; that is, finer meshes are generated for features. The displacement vector fields (DVFs) are specified at the mesh vertices to drive the deformation of original CT images. Digitally reconstructed radiographs (DRRs) of the deformed anatomy are generated and compared with corresponding 2D projections. DVFs are optimized to minimize the objective function including differences between DRRs and projections and the regularity. To further accelerate the above 3D-2D registration, a procedure to obtain good initial deformations by deforming the volume surface to match 2D body boundary on projections has been developed. This complete method is evaluated quantitatively by using several digital phantoms and data from head and neck cancer patients. The feature-based nonuniform meshing method leads to better results than either uniform orthogonal grid or uniform tetrahedral meshes.

  18. 3D-2D Deformable Image Registration Using Feature-Based Nonuniform Meshes

    Directory of Open Access Journals (Sweden)

    Zichun Zhong

    2016-01-01

    Full Text Available By using prior information of planning CT images and feature-based nonuniform meshes, this paper demonstrates that volumetric images can be efficiently registered with a very small portion of 2D projection images of a Cone-Beam Computed Tomography (CBCT scan. After a density field is computed based on the extracted feature edges from planning CT images, nonuniform tetrahedral meshes will be automatically generated to better characterize the image features according to the density field; that is, finer meshes are generated for features. The displacement vector fields (DVFs are specified at the mesh vertices to drive the deformation of original CT images. Digitally reconstructed radiographs (DRRs of the deformed anatomy are generated and compared with corresponding 2D projections. DVFs are optimized to minimize the objective function including differences between DRRs and projections and the regularity. To further accelerate the above 3D-2D registration, a procedure to obtain good initial deformations by deforming the volume surface to match 2D body boundary on projections has been developed. This complete method is evaluated quantitatively by using several digital phantoms and data from head and neck cancer patients. The feature-based nonuniform meshing method leads to better results than either uniform orthogonal grid or uniform tetrahedral meshes.

  19. A Central European precipitation climatology. Pt. I. Generation and validation of a high-resolution gridded daily data set (HYRAS)

    Energy Technology Data Exchange (ETDEWEB)

    Rauthe, Monika; Steiner, Heiko; Riediger, Ulf; Mazurkiewicz, Alex; Gratzki, Annegret [Deutscher Wetterdienst, Offenbach am Main (Germany)

    2013-10-15

    A new precipitation climatology (DWD/BfG-HYRAS-PRE) is presented which covers the river basins in Germany and neighbouring countries. In order to satisfy hydrological requirements, the gridded dataset has a high spatial resolution of 1 km{sup 2} and a daily temporal resolution that is based on up to 6200 precipitation stations within the spatial domain. The period of coverage extends from 1951 to 2006 for which gridded, daily precipitation fields were calculated from the station data using the REGNIE method. This is a combination between multiple linear regression considering orographical conditions and inverse distance weighting. One of the main attributes of the REGNIE method is the preservation of the station values for their respective grid cells. A detailed validation of the data set using cross-validation and Jackknifing showed both seasonally- and spatially-dependent interpolation errors. These errors, through further applications of the HYRAS data set within the KLIWAS project and other studies, provide an estimate of its certainty and quality. The mean absolute error was found to be less than 2 mm/day, but with both spatial and temporal variability. Additionally, the need for a high station network density was shown. Comparisons with other existing data sets show good agreement, with areas of orographical complexity displaying the largest differences within the domain. These errors are largely due to uncertainties caused by differences in the interpolation method, the station network density available, and the topographical information used. First climatological applications are presented and show the high potential of this new, high-resolution data set. Generally significant increases of up to 40% in winter precipitation and light decreases in summer are shown, whereby the spatial variability of the strength and significance of the trends is clearly illustrated. (orig.)

  20. Web-based workflows to produce ocean climatologies using DIVA (Data-Interpolating Variational Analysis) and Jupyter notebooks

    Science.gov (United States)

    Barth, Alexander; Troupin, Charles; Watelet, Sylvain; Alvera-Azcarate, Aida; Beckers, Jean-Marie

    2017-04-01

    The analysis tool DIVA (Data-Interpolating Variational Analysis) is designed to generate gridded fields or climatologies from in situ observations. The tool DIVA minimizes a cost function to ensure that the analysed field is relatively close to the observations and conforms at the same time to a set of dynamical constraints. In particular, DIVA naturally decouples water bodies which are not directly connected and it uses a (potentially spatial varying) correlation length to describe over which length-scale the analysed variable is correlated. In addition, DIVA can also take ocean currents into account to introduce a preferential direction for the correlation. The SeaDataCloud project aims to facilitate the access and use of ocean in situ data from 45 national oceanographic data centres and marine data centres from 35 countries riparian to all European seas. A central aspect is to provide web-based virtual research environment, where scientists can easily access and explore the data sets through the SeaDataCloud infrastructure. For users familiar with programming languages like Julia and Python, Jupyter (acronym for Julia, Python and R) notebooks provide an exciting way to analyse and to interact with ocean data. Jupyter notebooks are made up of cells that can be run individually and can contain text, formulas or code fragment. A complete notebook explains how to go from input data and parameters to a result, in this case a gridded field obtained executing DIVA. This presentation discusses this new web-based workflow for generating climatologies using DIVA. It explores its new possibilities in particular, in terms of improved ease of use and reproducibility of the results. The integration in the infrastructure of EUDAT is also addressed.

  1. Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation.

    Science.gov (United States)

    Rico, Alberto J; Dopeso-Reyes, Iria G; Martínez-Pinilla, Eva; Sucunza, Diego; Pignataro, Diego; Roda, Elvira; Marín-Ramos, David; Labandeira-García, José L; George, Susan R; Franco, Rafael; Lanciego, José L

    2017-05-01

    Although it has long been widely accepted that dopamine receptor types D1 and D2 form GPCR heteromers in the striatum, the presence of D1-D2 receptor heteromers has been recently challenged. In an attempt to properly characterize D1-D2 receptor heteromers, here we have used the in situ proximity ligation assay (PLA) in striatal sections comprising the caudate nucleus, the putamen and the core and shell territories of the nucleus accumbens. Experiments were carried out in control macaques as well as in MPTP-treated animals (with and without dyskinesia). Obtained data support the presence of D1-D2 receptor heteromers within all the striatal subdivisions, with the highest abundance in the accumbens shell. Dopamine depletion by MPTP resulted in an increase of D1-D2 density in caudate and putamen which was normalized by levodopa treatment. Two different sizes of heteromers were consistently found, thus suggesting that besides individual heteromers, D1-D2 receptor heteromers are sometimes organized in macromolecular complexes made of a number of D1-D2 heteromers. Furthermore, the PLA technique was combined with different neuronal markers to properly characterize the identities of striatal neurons expressing D1-D2 heteromers. We have found that striatal projection neurons giving rise to either the direct or the indirect basal ganglia pathways expressed D1-D2 heteromers. Interestingly, macromolecular complexes of D1-D2 heteromers were only found within cholinergic interneurons. In summary, here we provide overwhelming proof that D1 and D2 receptors form heteromeric complexes in the macaque striatum, thus representing a very appealing target for a number of brain diseases involving dopamine dysfunction.

  2. 16 CFR Appendix D2 to Part 305 - Water Heaters-Electric

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Water Heaters-Electric D2 Appendix D2 to... PRODUCTS REQUIRED UNDER THE ENERGY POLICY AND CONSERVATION ACT (âAPPLIANCE LABELING RULEâ) Pt. 305, App. D2 Appendix D2 to Part 305—Water Heaters—Electric Range Information CAPACITY FIRST HOUR RATING Range of...

  3. -Amphetamine and Antipsychotic Drug Effects on Latent Inhibition in Mice Lacking Dopamine D2 Receptors

    OpenAIRE

    Bay-Richter, C.; O'Callaghan, M J; N Mathur; O'Tuathaigh, C.M.P.; Heery, D M; Fone, K C F; Waddington, J. L.; Moran, P.M.

    2013-01-01

    Drugs that induce psychosis, such as -amphetamine (AMP), and those that alleviate it, such as antipsychotics, are suggested to exert behavioral effects via dopamine receptor D2 (D2). All antipsychotic drugs are D2 antagonists, but D2 antagonism underlies the severe and debilitating side effects of these drugs; it is therefore important to know whether D2 is necessary for their behavioral effects. Using D2-null mice (Drd 2 −/−), we first investigated whether D2 is required for AMP disruption ...

  4. M-theory Solutions Invariant under $D(2,1;\\gamma) \\oplus D(2,1;\\gamma)$

    CERN Document Server

    Bachas, Constantin; Estes, John; Krym, Darya

    2013-01-01

    We simplify and extend the construction of half-BPS solutions to 11-dimensional supergravity, with isometry superalgebra D(2,1;\\gamma) \\oplus D(2,1;\\gamma). Their space-time has the form AdS_3 x S^3 x S^3 warped over a Riemann surface \\Sigma. It describes near-horizon geometries of M2 branes ending on, or intersecting with, M5 branes along a common string. The general solution to the BPS equations is specified by a reduced set of data (\\gamma, h, G), where \\gamma is the real parameter of the isometry superalgebra, and h and G are functions on \\Sigma whose differential equations and regularity conditions depend only on the sign of \\gamma. The magnitude of \\gamma enters only through the map of h, G onto the supergravity fields, thereby promoting all solutions into families parametrized by |\\gamma|. By analyzing the regularity conditions for the supergravity fields, we prove two general theorems: (i) that the only solution with a 2-dimensional CFT dual is AdS_3 x S^3 x S^3 x R^2, modulo discrete identifications ...

  5. Ecodriver. D2.1: Dissemination and communication plan

    NARCIS (Netherlands)

    Quental, N.; Brouwers, R.F.T.

    2012-01-01

    The dissemination plan sets the reference for all planned dissemination activities during the project lifetime. It defines target groups, communication actions, how it will be performed, by whom and when.

  6. The climatology of the Red Sea - part 1: the wind

    KAUST Repository

    Langodan, Sabique

    2017-05-12

    The wind climatology of the Red Sea is described based on a 30-year high-resolution regional reanalysis generated using the Advanced Weather Research Forecasting model. The model was reinitialized on a daily basis with ERA-Interim global data and regional observations were assimilated using a cyclic three-dimensional variational approach. The reanalysis products were validated against buoy and scatterometers data. We describe the wind climatology and identify four major systems that determine the wind patterns in the Red Sea. Each system has a well-defined origin, and consequently different characteristics along the year. After analysing the relevant features of the basin in terms of their climatology, we investigate possible long-term trends in each system. It is found that there is a definite tendency towards lowering the strength of the wind speed, but at a different rate for different systems and periods of the year.

  7. Inoenue-Wigner contraction and D = 2 + 1 supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Concha, P.K.; Rodriguez, E.K. [Universidad Adolfo Ibanez, Departamento de Ciencias, Facultad de Artes Liberales, Vina del Mar (Chile); Universidad Austral de Chile, Instituto de Ciencias Fisicas y Matematicas, Valdivia (Chile); Fierro, O. [Universidad Catolica de la Santisima Concepcion, Departamento de Matematica y Fisica Aplicadas, Concepcion (Chile)

    2017-01-15

    We present a generalization of the standard Inoenue-Wigner contraction by rescaling not only the generators of a Lie superalgebra but also the arbitrary constants appearing in the components of the invariant tensor. The procedure presented here allows one to obtain explicitly the Chern-Simons supergravity action of a contracted superalgebra. In particular we show that the Poincare limit can be performed to a D = 2 + 1 (p,q) AdS Chern-Simons supergravity in presence of the exotic form. We also construct a new three-dimensional (2,0) Maxwell Chern-Simons supergravity theory as a particular limit of (2,0) AdS-Lorentz supergravity theory. The generalization for N = p + q gravitinos is also considered. (orig.)

  8. Analysis of ν2 of D 2S

    Science.gov (United States)

    Gillis, James R.; Blatherwick, Ronald D.; Bonomo, Francis S.

    1985-11-01

    The infrared spectrum of ν2 of D 2S was recorded from 740 to 1100 cm -1 on the University of Denver 50-cm FTIR spectrometer system. We have assigned 655 transitions from D 232S and 129 from D 234S, and have analyzed them using Watson's A-reduced Hamiltonian evaluated in the I r representation. We used the recently published D 232S and D 234S ground state Hamiltonian constants [C. Camy-Peyret, J. M. Flaud, L. Lechuga-Fossat and J. W. C. Johns, J. Mol. Spectrosc.109, 300-333 (1985)]. Upper state Hamiltonian constants were obtained from a fit of the ν2 transitions, keeping the ground state constants fixed while varying the upper state constants. The standard deviation of the D 232S ν2 fit is 0.0025 cm -1. The standard deviation of the D 234S ν2 fit is 0.0041 cm -1.

  9. Stark-effect investigations of the sodium D2 line

    Science.gov (United States)

    Windholz, L.; Musso, M.

    1989-03-01

    The Stark effect of the sodium D2 line was investigated by use of high-resolution laser-atomic-beam spectroscopy. The shift and splitting of the hyperfine components of the line could be obtained and compared with theoretical calculations. This allows the determination of the scalar and tensor polarizabilities with high accuracy to be 49.28(15) and -21.97(10) kHz/(kV/cm)2, respectively. These values are compared with semiempirical calculated polarizabilities. Additionally, the behavior of the relative intensity of the components could be studied. In fields greater than 100 kV/cm, the two groups of components with MJ=(1/2 and (3/2 are widely separated and the pattern of each group is independent from the field strength, showing an ``electrical'' Paschen-Back effect. The relative intensities agree satisfactorily with the computations.

  10. Thermodynamics of the localized D2-D6 system

    CERN Document Server

    Gómez-Reino, Marta; Schnitzer, H; Gomez-Reino, Marta; Naculich, Stephen; Schnitzer, Howard

    2004-01-01

    An exact fully-localized extremal supergravity solution for N_2 D2 branes and N_6 D6 branes, which is dual to 3-dimensional supersymmetric SU(N_2) gauge theory with N_6 fundamentals, was found by Cherkis and Hashimoto. In order to consider the thermal properties of the gauge theory we present the non-extremal extension of this solution to first order in an expansion near the core of the D6 branes. We compute the Hawking temperature and the black brane horizon area/entropy. The leading order entropy, which is proportional to N_2^{3/2} N_6^{1/2} T_H^2, is not corrected to first order in the expansion. This result is consistent with the analogous weak-coupling result at the correspondence point N_2 ~ N_6.

  11. Increased consumption of ethanol and sugar water in mice lacking the dopamine D2 long receptor.

    Science.gov (United States)

    Bulwa, Zachary B; Sharlin, Jordan A; Clark, Peter J; Bhattacharya, Tushar K; Kilby, Chessa N; Wang, Yanyan; Rhodes, Justin S

    2011-11-01

    Individual differences in dopamine D2 receptor (D2R) expression in the brain are thought to influence motivation and reinforcement for ethanol and other rewards. D2R exists in two isoforms, D2 long (D2LR) and D2 short (D2SR), produced by alternative splicing of the same gene. The relative contributions of D2LR versus D2SR to ethanol and sugar water drinking are not known. Genetic engineering was used to produce a line of knockout (KO) mice that lack D2LR and consequently have increased expression of D2SR. KO and wild-type (WT) mice of both sexes were tested for intake of 20% ethanol, 10% sugar water and plain tap water using established drinking-in-the-dark procedures. Mice were also tested for effects of the D2 antagonist eticlopride on intake of ethanol to determine whether KO responses were caused by lack of D2LR or overrepresentation of D2SR. Locomotor activity on running wheels and in cages without wheels was also measured for comparison. D2L KO mice drank significantly more ethanol than WT in both sexes. KO mice drank more sugar water than WT in females but not in males. Eticlopride dose dependently decreased ethanol intake in all groups except male KO. KO mice were less physically active than WT in cages with or without running wheels. Results suggest that overrepresentation of D2SR contributes to increased intake of ethanol in the KO mice. Decreasing wheel running and general levels of physical activity in the KO mice rules out the possibility that higher intake results from higher motor activity. Results extend the literature implicating altered expression of D2R in risk for addiction by delineating the contribution of individual D2R isoforms. These findings suggest that D2LR and D2SR play differential roles in consumption of alcohol and sugar rewards.

  12. Striatal dopamine (D2) receptor availability predicts socially desirable responding.

    Science.gov (United States)

    Reeves, Suzanne J; Mehta, Mitul A; Montgomery, Andrew J; Amiras, Dimitri; Egerton, Alice; Howard, Robert J; Grasby, Paul M

    2007-02-15

    Research in non-human primates has implicated striatal dopamine (D2) receptor function in the expression of social dominance--a fundamental component of social extraversion. We predicted that trait extraversion - indexed by the revised Eysenck Personality Questionnaire (EPQ-R) - would correlate with striatal DA (D2) receptor measures - indexed by [(11)C]-Raclopride binding potential (BP) - in 28 healthy post-menopausal females (mean age=75 years; range=58-91 years). Region of interest (ROI) and voxel-based statistical parametric mapping (SPM) analyses were performed, using a reference tissue model for [(11)C]-Raclopride. ROI analysis showed moderately significant negative correlations between extraversion and BP measures in the left caudate and between psychoticism scores and BP in the right putamen. Unexpectedly, scores on the Lie scale, a measure of socially desirable responding, were significantly and negatively correlated with BP measures in the putamen and survived Bonferroni correction on the right side. After controlling for the potential confounding of self-report bias in high Lie scorers, only the correlation between Lie scores and BP measures in the right putamen remained significant. Voxel-based analysis showed only Lie scores to be significantly and negatively correlated with BP measures in the right putamen. We explored this association further by applying an ROI-based approach to data on a previously scanned sample of young adults (n=13) and found a similar pattern of association, which achieved trend level significance in the right putamen. Although unanticipated, the relationship observed between BP measures in the right putamen and Lie scores is consistent with dopaminergic involvement in socially rewarding behaviour. How this relates to dopaminergic tone will need to be further explored.

  13. Marginal fluctuations as instantons on M2/D2-branes

    Energy Technology Data Exchange (ETDEWEB)

    Naghdi, M. [University of Ilam, Department of Physics, Faculty of Basic Sciences, Ilam (Iran, Islamic Republic of)

    2014-03-15

    We introduce some (anti-) M/D-branes through turning on the corresponding field strengths of the 11- and 10-dimensional supergravity theories over AdS{sub 4} x M{sup 7} {sup vertical} {sup stroke} {sup 6} spaces, where we use S{sup 7}/Z{sub k} and CP{sup 3} for the internal spaces. Indeed, when we add M2/D2-branes on the same directions with the near horizon branes of the Aharony-Bergman-Jafferis- Maldacena model, all symmetries and supersymmetries are preserved trivially. In this case, we obtain a localized object just in the horizon. This normalizable bulk massless scalar mode is a singlet of SO(8) and SU(4) x U(1), and it agrees with a marginal boundary operator of the conformal dimension of Δ{sub +} = 3. However, after performing a special conformal transformation, we see that the solution is localized in the Euclideanized AdS{sub 4} space and is attributable to the included anti-M2/D2-branes, which are also necessary to ensure that there is no back-reaction. The resultant theory now breaks all N = 8, 6 supersymmetries to N = 0, while the other symmetries are so preserved. The dual boundary operator is then set up from the skew-whiffing of the representations 8s and 8v for the supercharges and scalars, respectively, while the fermions remain fixed in 8c of the original theory. Besides, we also address another alternate bulk to boundary matching procedure through turning on one of the gauge fields of the full U(N){sub k} x U(N){sub -k} gauge group along the same lines with a similar situation to the one faced in the AdS{sub 5}/CFT{sub 4} correspondence. The latter approach covers the difficulty already faced with in the bulk-boundary matching procedure for k = 1, 2 as well. (orig.)

  14. A Smart Climatology of Evaporation Duct Height and Surface Radar Propagation in the Indian Ocean

    Science.gov (United States)

    2007-09-01

    closest Marsden square for the existing climatology and from the closest grid point for our smart climatology. 77 Comparison Climo vs Bouy 0 5 10...15 20 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec E D H ( m ) Bouy EDH AREPS MS066 NCEP 1970-2006 NCEP 1994/95 Comparison Climo vs Bouy 0 5 10...15 20 Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec E D H ( m ) Bouy EDH AREPS MS066 NCEP 1970-2006 NCEP 1994/95 Comparison Climo vs Bouy 0 5 10 15

  15. The Increasing Use of Remote Sensing Data in Studying the Climatological Impacts on Public Health

    Science.gov (United States)

    Kempler, Steven; Benedict, Karl; Ceccato, Pietro; Golden, Meredith; Maxwell, Susan; Morian, Stan; Soebiyanto, Radina; Tong, Daniel

    2011-01-01

    One of the more fortunate outcomes of the capture and transformation of remote sensing data into applied information is their usefulness and impacts to better understanding climatological impacts on public health. Today, with petabytes of remote sensing data providing global coverage of climatological parameters, public health research and policy decision makers have an unprecedented (and growing) data record that relates the effects of climatic parameters, such as rainfall, heat, soil moisture, etc. to incidences and spread of disease, as well as predictive modeling. In addition, tools and services that specifically serve public health researchers and respondents have grown in response to needs of the these information users.

  16. Polar low climatology over the Nordic and Barents seas based on satellite passive microwave data

    OpenAIRE

    Smirnova, Julia E.; Golubkin, Pavel A.; Bobylev, Leonid P.; Zabolotskikh, Elizaveta; Chapron, Bertrand

    2015-01-01

    A new climatology of polar lows over the Nordic and Barents seas for 14 seasons (1995/1996-2008/2009) is presented. For the first time in climatological studies of polar lows an approach based on satellite passive microwave data was adopted for polar low identification. A total of 637 polar lows were found in 14 extended winter seasons by combining total atmospheric water vapor content and sea surface wind speed fields retrieved from Special Sensor Microwave/Imager data. As derived, the polar...

  17. Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.

    Science.gov (United States)

    Black, Kevin J; Snyder, Abraham Z; Mink, Jonathan W; Tolia, Veeral N; Revilla, Fredy J; Moerlein, Stephen M; Perlmutter, Joel S

    2014-01-01

    The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen. In isolated focal dystonia, whole putaminal binding of dopamine D2-like receptor radioligands is quantitatively decreased, but it has not been known whether selected parts of the putamen are differentially affected depending upon the body part affected by dystonia. The radioligand [(18)F]spiperone binds predominantly to D2-like receptors in striatum. We hypothesized that the spatial location of [(18)F]spiperone binding within the putamen would differ in patients with dystonia limited to the hand versus the face, and we tested that hypothesis using positron emission tomography and magnetic resonance imaging. To address statistical and methodological concerns, we chose a straightforward but robust image analysis method. An automated algorithm located the peak location of [(18)F]spiperone binding within the striatum, relative to a brain atlas, in each of 14 patients with cranial dystonia and 8 patients with hand dystonia. The mean (left and right) |x|, y, and z coordinates of peak striatal binding for each patient were compared between groups by t test. The location of peak [(18)F]spiperone binding within the putamen differed significantly between groups (cranial dystonia zputamen depending on the body part manifesting dystonia.

  18. The WRF Model Forecast-Derived Low-Level Wind Shear Climatology over the United States Great Plains

    Directory of Open Access Journals (Sweden)

    Sukanta Basu

    2010-02-01

    Full Text Available For wind resource assessment projects, it is common practice to use a power-law relationship (U(z ~ zα and a fixed shear exponent (α = 1=7 to extrapolate the observed wind speed from a low measurement level to high turbine hub-heights. However, recent studies using tall-tower observations have found that the annual average shear exponents at several locations over the United States Great Plains (USGP are significantly higher than 1=7. These findings highlight the critical need for detailed spatio-temporal characterizations of wind shear climatology over the USGP, where numerous large wind farms will be constructed in the foreseeable future. In this paper, a new generation numerical weather prediction model—the Weather Research and Forecasting (WRF model, a fast and relatively inexpensive alternative to time-consuming and costly tall-tower projects, is utilized to determine whether it can reliably estimate the shear exponent and the magnitude of the directional shear at any arbitrary location over the USGP. Our results indicate that the WRF model qualitatively captures several low-level wind shear characteristics. However, there is definitely room for physics parameterization improvements for the WRF model to reliably represent the lower part of the atmospheric boundary layer.

  19. Revolutionary Climatology: Rings of Saturn, Ringed by Red Lightning

    Directory of Open Access Journals (Sweden)

    Sarah K. Stanley

    2016-05-01

    Full Text Available Walter Benjamin’s concept of historical materialism is considered as a practice of media archaeology invented through literary montage and photo philosophy. The Arcades Project that facilitated this new research methodology involving a mobile archive. The main case involving architectural theory considers how Benjamin redeployed Sigfried Giedion and Laszlo Moholy-Nagy’s Building in France as a media environment, drawing upon its layout design, photo illustrations and textual systems. In terms of his urban writing, a reading of ‘A Berlin Chronicle’ considers how the diagram contributes to Benjamin’s archaeological methods, as a theory to generate site writing. Benjamin’s mode of media archaeology is then employed to map the arcades architecture onto the train stations and libraries in Berlin and Paris, sites that informed The Arcades Project. The final section assembles a set of citations as ‘Revolutionary Climatology’, thought-images as flashes of red lightning.

  20. D2.3 - ENCOURAGE platform reference architecture

    DEFF Research Database (Denmark)

    Ferreira, Luis Lino; Pinho, Luis Miguel; Albano, Michele

    2012-01-01

    This document describes the reference architecture of the ENCOURAGE platform, together with the interconnection of the platform with the external environment. The document is the outcome of task 2.3 (Design of System Architecture) of the ENCOURAGE project, and sets, together with the remaining do...

  1. D2.3 - ENCOURAGE platform reference architecture

    DEFF Research Database (Denmark)

    Ferreira, Luis Lino; Pinho, Luis Miguel; Albano, Michele

    2012-01-01

    This document describes the reference architecture of the ENCOURAGE platform, together with the interconnection of the platform with the external environment. The document is the outcome of task 2.3 (Design of System Architecture) of the ENCOURAGE project, and sets, together with the remaining do...

  2. Loqs depends on R2D2 to localize in D2 body-like granules and functions in RNAi pathways in silkworm cells.

    Science.gov (United States)

    Zhu, Li; Tatsuke, Tsuneyuki; Xu, Jian; Li, Zhiqing; Mon, Hiroaki; Lee, Jae Man; Kusakabe, Takahiro

    2015-09-01

    The phenomenon of RNA interference (RNAi) has been found in various organisms. However, the proteins implicated in RNAi pathway in different species show distinct roles. Knowledge on the underlying mechanism of lepidopteron RNAi is quite lacking such as the roles of Loquacious (Loqs) and R2D2, the dsRNA-binding proteins in silkworm RNAi pathway. Here, we report that Loqs and R2D2 protein depletion affected efficiency of dsRNA-mediated RNAi pathway. Besides, Loqs was found to co-localize with Dicer2 to some specific cytoplasmic foci, which were looked like D2-bodies marked by R2D2 and Dicer2 in Fly cells, thereby calling the foci as D2 body-like granules. Using RNAi methods, Loqs was found to be the key protein in these granules, although R2D2 determined the localization of Loqs in D2 body-like granules. Interestingly, in the R2D2-depeted silkworm cells, the formation of processing bodies, another cytoplasmic foci, was affected. These data indicated R2D2 regulated these two kinds of cytoplasmic foci. Domain deletion analysis demonstrated that dsRBD 1 and 2 were required for Loqs in D2 body-like granules and dsRBD 2 and 3 were required for Loqs to interact with R2D2 and Ago1, respectively. Altogether, our observations provide important information for further study on D2 body-like granules, the newly found cytoplasmic foci in silkworm cells.

  3. 17 CFR 240.11d2-1 - Exemption from Section 11(d)(2) for certain broker-dealers effecting transactions for customers...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption from Section 11(d)(2... accounts. 240.11d2-1 Section 240.11d2-1 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... section 4f(a)(1) of the Commodity Exchange Act (7 U.S.C. 6f(a)(1)), to the extent that it effects...

  4. Generation of UV laser light by stimulated Raman scattering in D2, D2/Ar and D2/He using a pulsed Nd:YAG laser at 355nm

    Institute of Scientific and Technical Information of China (English)

    徐贲; 岳古明; 张寅超; 胡欢陵; 周军; 胡顺星

    2003-01-01

    A pulsed Nd:YAG laser at 355nm is used to pump Raman cell filled with D2,D2/Ar and D2/He.With adequately adjusted parameters,the maximum photon conversion efficiency of the first-order Stokes light(S1,396.796nm)reaches 33.33% in D2/Ar and the stability of S1 in pure D2 is fairly high,the energy drift being less than 10% when the pump energy drifts in the range of 5%.The conversion efficiency and stability,which are functions of the composition and pressure of the Raman medium and the energy of pump laser,are investigated.The result has been used to optimize the laser transmitter system for a differential absorption lidar system to measure NO2 concentration profiles.

  5. Thermodynamics of the localized D2-D6 system

    Energy Technology Data Exchange (ETDEWEB)

    Gomez-Reino, Marta [Martin Fisher School of Physics, Brandeis University, Waltham, MA 02454 (United States)]. E-mail: marta@brandeis.edu; Naculich, Stephen G. [Department of Physics, Bowdoin College, Brunswick, ME 04011 (United States)]. E-mail: naculich@bowdoin.edu; Schnitzer, Howard J. [Martin Fisher School of Physics, Brandeis University, Waltham, MA 02454 (United States)]. E-mail: schnitzer@brandeis.edu

    2005-05-02

    An exact fully-localized extremal supergravity solution for N{sub 2} D2-branes and N{sub 6} D6-branes, which is dual to 3-dimensional supersymmetric SU(N{sub 2}) gauge theory with N{sub 6} fundamentals, was found by Cherkis and Hashimoto. In order to consider the thermal properties of the gauge theory we present the non-extremal extension of this solution to first order in an expansion near the core of the D6-branes. We compute the Hawking temperature and the black-brane horizon area/entropy. The leading-order entropy, which is proportional to N{sub 2}{sup 3/2}N{sub 6}{sup 1/2}T{sub H}{sup 2}, is not corrected to first order in the expansion. This result is consistent with the analogous weak-coupling result at the correspondence point N{sub 2} similar to N{sub 6}.

  6. Determination of the evaporation coefficient of D2O

    Directory of Open Access Journals (Sweden)

    R. C. Cohen

    2008-11-01

    Full Text Available The evaporation rate of D2O has been determined by Raman thermometry of a droplet train (12–15 μm diameter injected into vacuum (~10-5 torr. The cooling rate measured as a function of time in vacuum was fit to a model that accounts for temperature gradients between the surface and the core of the droplets, yielding an evaporation coefficient (γe of 0.57±0.06. This is nearly identical to that found for H2O (0.62±0.09 using the same experimental method and model, and indicates the existence of a kinetic barrier to evaporation. The application of a recently developed transition-state theory (TST model suggests that the kinetic barrier is due to librational and hindered translational motions at the liquid surface, and that the lack of an isotope effect is due to competing energetic and entropic factors. The implications of these results for cloud and aerosol particles in the atmosphere are discussed.

  7. Higher derivative massive spin-3 models in D =2 +1

    Science.gov (United States)

    Dalmazi, D.; Mendonça, E. L.

    2016-07-01

    We find new higher derivative models describing a parity doublet of massive spin-3 modes in D =2 +1 dimensions. One of them is of fourth order in derivatives while the other one is of sixth order. They are complete, in the sense that they contain the auxiliary scalar field required to remove spurious degrees of freedom. Both of them are obtained through the master action technique starting with the usual (second-order) spin-3 Singh-Hagen model, which guarantees that they are ghost free. The fourth- and sixth-order terms are both invariant under (transverse) Weyl transformations, quite similarly to the fourth-order K -term of the "new massive gravity." The sixth-order term slightly differs from the product of the Schouten by the Einstein tensor, both of third order in derivatives. It is also possible to write down the fourth-order term as a product of a Schouten-like by an Einstein-like tensor (both of second order in derivatives) in close analogy with the K -term.

  8. Macroscopic Behavior of Nematics with D2d Symmetry

    Science.gov (United States)

    Pleiner, Harald; Brand, Helmut R.

    2010-03-01

    We discuss the symmetry properties and the macroscopic behavior of a nematic liquid crystal phase with D2d symmetry. Such a phase is a prime candidate for nematic phases made from banana-shaped molecules where the usual quadrupolar order coexists with octupolar (tetrahedratic) order. The resulting nematic phase is non-polar. While this phase could resemble the classic D∞h nematic in the polarizing microscope, it has many static as well as reversible and irreversible properties unknown to non-polar nematics without octupolar order. In particular, there is a linear gradient term in the free energy that selects parity leading to ambidextrously helical ground states when the molecules are achiral. In addition, there are static and irreversible coupling terms of a type only met otherwise in macroscopically chiral liquid crystals, e.g. the ambidextrous analogues of Lehmann-type effects known from cholesteric liquid crystals. Finally, we discuss certain nonlinear aspects of the dynamics related to the non-commutativity of three-dimensional finite rotations as well as other structural nonlinear hydrodynamic effects.

  9. U.S. West Coast MODIS Aqua High Resolution SST Climatology Fields (July 2002 - March 2014)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This suite of CHLA and SST climatology and anomaly data products are derived from daily, 0.0125 degree x 0.0125 degree, MODIS Aqua CHLA and SST fields that cover the...

  10. U.S. West Coast MODIS Aqua High Resolution CHLA Climatology Fields (July 2002 - March 2014)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This suite of CHLA and SST climatology and anomaly data products are derived from daily, 0.0125 degree x 0.0125 degree, MODIS Aqua CHLA and SST fields that cover the...

  11. Aspectos de la climatología del estado de México

    Directory of Open Access Journals (Sweden)

    Ernesto Jáuregui Ostos

    1981-01-01

    Full Text Available The weather systems affecting the State of Mexico are discussed. The main climatological variables are examined for this State located in central Mexico especially those affecting crops grown in this part of Mexico, such as precipitation variability, temperature, frequency of hail, thunder stormes, freezing temperatures etc.

  12. Analysis of freshwater flux climatology over the Indian Ocean using the HOAPS data

    Digital Repository Service at National Institute of Oceanography (India)

    RameshKumar, M.R.; Schulz, J.

    to the lack of in-situ measurements. The climatology and the annual cycle of the freshwater flux over the IO are examined using the newly available Hamburg Ocean Atmosphere Parameters and Fluxes from Satellite data (HOAPS). This data set has been derived from...

  13. A global climatology for equatorial plasma bubbles in the topside ionosphere

    Directory of Open Access Journals (Sweden)

    L. C. Gentile

    2006-03-01

    Full Text Available We have developed a global climatology of equatorial plasma bubble (EPB occurrence based on evening sector plasma density measurements from polar-orbiting Defense Meteorological Satellite Program (DMSP spacecraft during 1989-2004. EPBs are irregular plasma density depletions in the post-sunset ionosphere that degrade communication and navigation signals. More than 14400 EPBs were identified in ~134000 DMSP orbits. DMSP observations basically agree with Tsunoda's (1985 hypothesis that EPB rates peak when the terminator is aligned with the Earth's magnetic field, but there are also unpredicted offsets in many longitude sectors. We present an updated climatology for the full database from 1989-2004 along with new plots for specific phases of the solar cycle: maximum 1989-1992 and 1999-2002, minimum 1994-1997, and transition years 1993, 1998, and 2003. As expected, there are significant differences between the climatologies for solar maximum and minimum and between the two solar maximum phases as well. We also compare DMSP F12, F14, F15, and F16 observations at slightly different local times during 2000-2004 to examine local time effects on EPB rates. The global climatologies developed using the DMSP EPB database provide an environmental context for the long-range prediction tools under development for the Communication/Navigation Outage Forecasting System (C/NOFS mission.

  14. Trends in the Indian Ocean Climatology due to anthropogenic induced global warming

    CSIR Research Space (South Africa)

    Meyer, AA

    2009-09-01

    Full Text Available clearly show that due to global warming the South West Indian Ocean Climatology has been changing and that this changing trend will continue into the future as global warming continues. The impacts of regional oceanic climate change on the regions coastal...

  15. A Wildfire-relevant climatology of the convective environment of the United States

    Science.gov (United States)

    Brian E. Potter; Matthew A. Anaya

    2015-01-01

    Convective instability can influence the behaviour of large wildfires. Because wildfires modify the temperature and moisture of air in their plumes, instability calculations using ambient conditions may not accurately represent convective potential for some fire plumes. This study used the North American Regional Reanalysis to develop a climatology of the convective...

  16. Offshore wind climatology based on synergetic use of Envisat ASAR, ASCAT and QuikSCAT

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Mouche, Alexis; Badger, Merete

    2015-01-01

    The offshore wind climatology in the Northern European seas is analysed from ten years of Envisat synthetic aperture radar (SAR) images using a total of 9256 scenes, ten years of QuikSCAT and two years of ASCAT gridded ocean surface vector wind products and high-quality wind observations from four...

  17. Simulated Future Air Temperature and Precipitation Climatology and Variability in the Mediterranean Basin by Using Downscaled Global Climate Model Outputs

    Science.gov (United States)

    Ozturk, Tugba; Pelin Ceber, Zeynep; Türkeş, Murat; Kurnaz, M. Levent

    2014-05-01

    The Mediterranean Basin is one of the regions that shall be affected most by the impacts of the future climate changes on temperature regime including changes in heat waves intensity and frequency, seasonal and interannual precipitation variability including changes in summer dryness and drought events, and hydrology and water resources. In this study, projected future changes in mean air temperature and precipitation climatology and inter-annual variability over the Mediterranean region were simulated. For performing this aim, the future changes in annual and seasonal averages for the future period of 2070-2100 with respect to the period from 1970 to 2000 were investigated. Global climate model outputs of the World Climate Research Program's (WCRP's) Coupled Model Intercomparison Project Phase 3 (CMIP3) multi-model dataset were used. SRES A2, A1B and B1 emission scenarios' outputs of the Intergovernmental Panel on Climate Change (IPCC) were used in future climate model projections. Future surface mean air temperatures of the larger Mediterranean basin increase mostly in summer and least in winter, and precipitation amounts decreases in all seasons at almost all parts of the basin. Future climate signals for surface air temperatures and precipitation totals will be much larger than the inter-model standard deviation. Inter-annual temperature variability increases evidently in summer season and decreases in the northern part of the domain in the winter season, while precipitation variability increases in almost all parts of domain. Probability distribution functions are found to be shifted and flattened for future period compared to reference period. This indicates that occurrence frequency and intensity of extreme weather conditions will increase in the future period. This work has been supported by Bogazici University BAP under project number 7362. One of the authors (MLK) was partially supported by Mercator-IPC Fellowship Program.

  18. Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.

    Science.gov (United States)

    Ebersole, Brittany; Petko, Jessica; Woll, Matthew; Murakami, Shoko; Sokolina, Kate; Wong, Victoria; Stagljar, Igor; Lüscher, Bernhard; Levenson, Robert

    2015-01-01

    We have used bioorthogonal click chemistry (BCC), a sensitive non-isotopic labeling method, to analyze the palmitoylation status of the D2 dopamine receptor (D2R), a G protein-coupled receptor (GPCR) crucial for regulation of processes such as mood, reward, and motor control. By analyzing a series of D2R constructs containing mutations in cysteine residues, we found that palmitoylation of the D2R most likely occurs on the C-terminal cysteine residue (C443) of the polypeptide. D2Rs in which C443 was deleted showed significantly reduced palmitoylation levels, plasma membrane expression, and protein stability compared to wild-type D2Rs. Rather, the C443 deletion mutant appeared to accumulate in the Golgi, indicating that palmitoylation of the D2R is important for cell surface expression of the receptor. Using the full-length D2R as bait in a membrane yeast two-hybrid (MYTH) screen, we identified the palmitoyl acyltransferase (PAT) zDHHC4 as a D2R interacting protein. Co-immunoprecipitation analysis revealed that several other PATs, including zDHHC3 and zDHHC8, also interacted with the D2R and that each of the three PATs was capable of affecting the palmitoylation status of the D2R. Finally, biochemical analyses using D2R mutants and the palmitoylation blocker, 2-bromopalmitate indicate that palmitoylation of the receptor plays a role in stability of the D2R.

  19. Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.

    Directory of Open Access Journals (Sweden)

    Brittany Ebersole

    Full Text Available We have used bioorthogonal click chemistry (BCC, a sensitive non-isotopic labeling method, to analyze the palmitoylation status of the D2 dopamine receptor (D2R, a G protein-coupled receptor (GPCR crucial for regulation of processes such as mood, reward, and motor control. By analyzing a series of D2R constructs containing mutations in cysteine residues, we found that palmitoylation of the D2R most likely occurs on the C-terminal cysteine residue (C443 of the polypeptide. D2Rs in which C443 was deleted showed significantly reduced palmitoylation levels, plasma membrane expression, and protein stability compared to wild-type D2Rs. Rather, the C443 deletion mutant appeared to accumulate in the Golgi, indicating that palmitoylation of the D2R is important for cell surface expression of the receptor. Using the full-length D2R as bait in a membrane yeast two-hybrid (MYTH screen, we identified the palmitoyl acyltransferase (PAT zDHHC4 as a D2R interacting protein. Co-immunoprecipitation analysis revealed that several other PATs, including zDHHC3 and zDHHC8, also interacted with the D2R and that each of the three PATs was capable of affecting the palmitoylation status of the D2R. Finally, biochemical analyses using D2R mutants and the palmitoylation blocker, 2-bromopalmitate indicate that palmitoylation of the receptor plays a role in stability of the D2R.

  20. Qualified temperature, salinity and dissolved oxygen climatologies in a changing Adriatic Sea

    Directory of Open Access Journals (Sweden)

    M. Lipizer

    2014-02-01

    Full Text Available An updated climatology, based on a comprehensive dataset (1911–2009 of temperature, salinity and dissolved oxygen, has been produced for the whole Adriatic Sea with the Variational Inverse Method using the DIVA software. Climatological maps were produced at 26 levels and validated with Ordinary Cross Validation and with real vs. synthetic Temperature–Salinity diagram intercomparison. The concept of Climatology–Observation Misfit (COM has been introduced as an estimate of the physical variability associated with the climatological structures. In order to verify the temporal stability of the climatology, long-term variability has been investigated in the Mid Adriatic and the South Adriatic Pits, regarded as the most suitable records of possible long-term changes. Compared with previous climatologies, this study reveals a surface temperature rise (up to 2 °C, a clear deep dissolved oxygen minimum in the South Adriatic Gyre and a bottom summer oxygen minimum in the North Adriatic. Below 100 m all properties profoundly differ between the Middle and the South Adriatic. The South Adriatic Pit clearly shows the remote effects of the Eastern Mediterranean Transient, while no effect is observed in Middle Adriatic Pits. The deepest part of the South Adriatic seems now to be significantly saltier (+0.18 since the period 1911–1914, with an increase of +0.018 decade−1 since the late 1940s and warmer (+0.54 °C since 1911–1914, even though a long-term temperature trend could not be statistically demonstrated. Conversely, the Middle Adriatic Pits present a long-term increase in apparent oxygen utilisation (+0.77 mL L−1 since 1911–1914, with a constant increase of +0.2 mL L−1 decade−1 after the 1970s.

  1. Climatology of middle atmospheric water vapour above the ALOMAR observatory in northern Norway

    Directory of Open Access Journals (Sweden)

    K. Hallgren

    2012-12-01

    Full Text Available We have been observing the water vapour line at 22.235 GHz above ALOMAR in northern Norway (69° N, 16° E since early 1996 with ground-based microwave spectrometers (WASPAM and cWASPAM and will here describe a climatology based on these observations. Maintenance, different spectrometers and upgrades of the hardware have slightly changed the instruments. Therefore great care has been taken to make sure the different datasets are compatible with each other. In order to maximise the sensitivity at high altitude for the older instrument a long integration time (168 h was chosen. The complete dataset was thereafter recompiled into a climatology which describes the yearly variation of water vapour at polar latitudes on a weekly basis. The atmosphere is divided into 16 layers between 40–80 km, each 2.5 km thick. The dataset, spanning 15 yr from 1996 to 2010, enabled us to investigate the long-term behaviour of water vapour at these latitudes. By comparing the measurements from every year to the climatological mean we were also able to look for indications of trends in the dataset at different altitudes during the time period of our observations. In general there is a weak negative trend which differs slightly at different altitudes. There are however no drifts in the annual variation of water vapour from the point of view of onset of summer and winter. We compare our climatology to the reference water vapour profiles from AFGL, a free and easy accessible reference atmosphere. There are strong deviations between our observations and the reference profile, therefore we publish our climatological dataset in a table in the paper.

  2. Microstructural Quantification of Rapidly Solidified Undercooled D2 Tool Steel

    Science.gov (United States)

    Valloton, J.; Herlach, D. M.; Henein, H.; Sediako, D.

    2017-10-01

    Rapid solidification of D2 tool steel is investigated experimentally using electromagnetic levitation (EML) under terrestrial and reduced gravity conditions and impulse atomization (IA), a drop tube type of apparatus. IA produces powders 300 to 1400 μm in size. This allows the investigation of a large range of cooling rates ( 100 to 10,000 K/s) with a single experiment. On the other hand, EML allows direct measurements of the thermal history, including primary and eutectic nucleation undercoolings, for samples 6 to 7 mm in diameter. The final microstructures at room temperature consist of retained supersaturated austenite surrounded by eutectic of austenite and M7C3 carbides. Rapid solidification effectively suppresses the formation of ferrite in IA, while a small amount of ferrite is detected in EML samples. High primary phase undercoolings and high cooling rates tend to refine the microstructure, which results in a better dispersion of the eutectic carbides. Evaluation of the cell spacing in EML and IA samples shows that the scale of the final microstructure is mainly governed by coarsening. Electron backscattered diffraction (EBSD) analysis of IA samples reveals that IA powders are polycrystalline, regardless of the solidification conditions. EBSD on EML samples reveals strong differences between the microstructure of droplets solidified on the ground and in microgravity conditions. While the former ones are polycrystalline with many different grains, the EML sample solidified in microgravity shows a strong texture with few much larger grains having twinning relationships. This indicates that fluid flow has a strong influence on grain refinement in this system.

  3. Simulated Future Changes in Air Temperature and Precipitation Climatology in the Central Asia Cordex Region 8 BY Using RegCM 4.3.5

    Science.gov (United States)

    Ozturk, Tugba; Türkeş, Murat; Kurnaz, M. Levent

    2014-05-01

    In this study, projected future changes for the period of 2071-2100 in mean surface air temperature and precipitation climatology and variability over the large Central Asia region with respect to present climate (1971 to 2000) were simulated based on the RCP 4.5 and RCP 8.5 emission scenarios. Regional Climate Model (RegCM4.3) of the International Centre for Theoretical Physics (ICTP) was used for projections of future and present climate conditions. Hadley Global Environment Model 2 (HadGEM2) of the Met Office Hadley Centre was downscaled for the Cordex Region 8. We investigated the seasonal time-scale performance of RegCM4.3.5 in reproducing observed climatology over the domain of Central Asia by usingtwo different emission scenario datasets for three future periods. The regional model is capable of reproducing the observed climate with few exceptions, which are due to the meteorological and physical geographical complexities of the domain. For the future climatology of the domain, the regional model predicts relatively high warming in the warm season and northern part of the domain at cold season with a decrease in precipitation amounts almost all part of the domain. The results of our study showed that surface air temperatures in the region will increase from 3° C up to more than 7° C on average according to the emission scenarios for the period of 2070-2100 with respect to past period of 1970-2000. In the future, a decrease in the amount of precipitation is also predicted for the region. The projected warming and decrease in precipitation for the domain may strongly affect the ecological and socio-economic systems including agriculture, natural biomes, hydrology and water resources of this region, which is already a mostly arid and semi-arid environment. This work has been supported by Bogazici University BAP under project number 7362. One of the authors (MLK) was partially supported by Mercator-IPC Fellowship Program.

  4. A global, space-based stratospheric aerosol climatology: 1979 to 2014

    Science.gov (United States)

    Thomason, L. W.; Vernier, J. P.; Bourassa, A. E.; Millan, L.; Manney, G. L.

    2016-12-01

    Herein, we report on a global space-based stratospheric aerosol climatology (GloSSAC) that has been developed to support Coupled Model Intercomparison Project Phase 6 (CMIP6) (REF to CMIP6 and ETH work). GloSSAC is most closely related to the ASAP[SPARC, 2006] and CCMI data sets and follows a similar approach used to produce those data sets. It is primarily built using space-based measurements by a number of instruments including the SAGE series, OSIRIS, CALIPSO, CLAES and HALOE. The data set is presented as monthly depictions for 80S to 80N and from at least the tropopause to 40 km. The data set consists primarily of measurements by the instruments at their native wavelength and measurement type (e.g., extinction coefficient). However, every bin in these monthly grids receives measured or indirectly inferred values for aerosol extinction coefficient at 525 and 1020 nm. Generally, bins where no data are available are filled via simple linear interpolation in time only. The exceptions are in the SAGE I/II gap from 1982 to 1984 where data from SAM II and ground-based and airborne lidar data sets are used to span the 3 years between the end of the SAGE I mission in November 1981 and the beginning of the SAGE II mission in October 1984. Ground-based lidar also supplements space-based data in the months following the Pinatubo eruption when much of the lower stratosphere is too optically opaque for occultation measurements. This data set includes total aerosol surface area density and volume estimates based on Thomason et al.[2008] though these should be interpreted as bounding values (low and high) rather than functional aerosol parameters that are generally produced from this and predecessor data sets by other parties. Unlike previous versions of this data set, GloSSAC has been permanently archived at NASA's Atmospheric Science Data Center and a digital object identifier (doi) for GloSSAC is available. SPARC (2006), Assessment of Stratospheric Aerosol Properties (ASAP

  5. Towards a climatology of tropical cyclone morphometric structures using a newly standardized passive microwave satellite dataset

    Science.gov (United States)

    Cossuth, J.; Hart, R. E.

    2013-12-01

    storm's rainband and eyewall organization. Ultimately, this project develops a consistent climatology of TC structures using a new database of research-quality historical TC satellite microwave observations. Not only can such data sets more accurately study TC structural evolution, but they may facilitate automated TC intensity estimates and provide methods to enhance current operational and research products, such as at the NRL TC webpage (http://www.nrlmry.navy.mil/TC.html). The process of developing the dataset and possible objective definitions of TC structures using passive microwave imagery will be described, with preliminary results suggesting new methods to identify TC structures that may interrogate and expand upon physical and dynamical theories. Structural metrics such as threshold analysis of the outlines of the TC shape as well as methods to diagnose the inner-core size, completion, and magnitude will be introduced.

  6. Deficient Dopamine D2 Receptor Function Causes Renal Inflammation Independently of High Blood Pressure

    OpenAIRE

    Yanrong Zhang; Santiago Cuevas; Asico, Laureano D.; Crisanto Escano; Yu Yang; Pascua, Annabelle M.; Xiaoyan Wang; Jones, John E.; David Grandy; Gilbert Eisner; Pedro A. Jose; Ines Armando

    2012-01-01

    Renal dopamine receptors participate in the regulation of blood pressure. Genetic factors, including polymorphisms of the dopamine D(2) receptor gene (DRD2) are associated with essential hypertension, but the mechanisms of their contribution are incompletely understood. Mice lacking Drd2 (D(2)-/-) have elevated blood pressure, increased renal expression of inflammatory factors, and renal injury. We tested the hypothesis that decreased dopamine D(2) receptor (D(2)R) function increases vulnerab...

  7. Satisfactory surgical outcome of T2 gastric cancer after modified D2 lymphadenectomy.

    Science.gov (United States)

    Zhang, Shupeng; Wu, Liangliang; Wang, Xiaona; Ding, Xuewei; Liang, Han

    2017-04-01

    Though D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer (GC), the modified D2 (D1 + 7, 8a and 9) lymphadenectomy may be more suitable than D2 dissection for T2 stage GC. The purpose of this study is to elucidate whether the surgical outcome of modified D2 lymphadenectomy was comparable to that of standard D2 dissection in T2 stage GC patients. A retrospective cohort study with 77 cases and 77 controls matched for baseline characteristics was conducted. Patients were categorized into two groups according to the extent of lymphadenectomy: the modified D2 group (mD2) and the standard D2 group (D2). Surgical outcome and recurrence date were compared between the two groups. The 5-year overall survival (OS) rate was 71.4% for patients accepted mD2 lymphadenectomy and 70.1% for those accepted standard D2, respectively, and the difference was not statistically significant. Multivariate survival analysis revealed that curability, tumor size, TNM stage and postoperative complications were independently prognostic factors for T2 stage GC patients. Patients in the mD2 group tended to have less intraoperative blood loss (P=0.001) and shorter operation time (PD2 group. While there were no significant differences in recurrence rate and types, especially lymph node recurrence, between the two groups. The surgical outcome of mD2 lymphadenectomy was equal to that of standard D2, and the use of mD2 instead of standard D2 can be a better option for T2 stage GC.

  8. Implantation of Energetic D+ Ions into Carbon Dioxide Ices and Implications for our Solar System: Formation of D2O and D2CO3

    Science.gov (United States)

    Bennett, Chris J.; Ennis, Courtney P.; Kaiser, Ralf I.

    2014-10-01

    Carbon dioxide (CO2) ices were irradiated with energetic D+ ions to simulate the exposure of oxygen-bearing solar system ices to energetic protons from the solar wind and magnetospheric sources. The formation of species was observed online and in situ by exploiting FTIR spectroscopy. Molecular products include ozone (O3), carbon oxides (CO3(C 2v , D 3h ), CO4, CO5, CO6), D2-water (D2O), and D2-carbonic acid (D2CO3). Species released into the gas phase were sampled via a quadrupole mass spectrometer, and possible minor contributions from D2-formaldehyde (D2CO), D4-methanol (CD3OD), and D2-formic acid (DCOOD) were additionally identified. The feasibility of several reaction networks was investigated by determining their ability to fit the observed temporal column densities of 10 key species that were quantified during the irradiation period. Directly relevant to the CO2-bearing ices of comets, icy satellites in the outer solar system, and the ice caps on Mars, this work illustrates for the first time that D2-water is formed as a product of the exposure of CO2 ices to D+ ions. These findings provide strong support for water formation from oxygen-bearing materials via non-thermal hydrogen atoms, and predict reaction pathways that are likely to be unfolding on the surfaces of asteroids and the Moon.

  9. Agonist signalling properties of radiotracers used for imaging of dopamine D-2/3 receptors

    NARCIS (Netherlands)

    van Wieringen, Jan-Peter; Michel, Martin C.; Janssen, Henk M.; Janssen, Anton G.; Elsinga, Philip H.; Booij, Jan

    2014-01-01

    Background: Dopamine D-2/3 receptor (D2/3R) agonist radiopharmaceuticals are considered superior to antagonists to detect dopamine release, e.g. induced by amphetamines. Agonists bind preferentially to the high-affinity state of the dopamine D2R, which has been proposed as the reason why agonists ar

  10. VirD2 of Agrobacterium tumefaciens : functional domains and biotechnological applications

    NARCIS (Netherlands)

    Kregten, Maartje van

    2011-01-01

    Agrobacterium tumefaciens is a pathogenic bacterium, which can genetically transform plants and other organisms. It does so by translocating a part of its DNA, the T-strand, in complex with the relaxase protein VirD2. We have shown that VirD2 is the determinant of translocation of the VirD2-T-strand

  11. 26 CFR 1.643(d)-2 - Illustration of the provisions of section 643.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Illustration of the provisions of section 643. 1.643(d)-2 Section 1.643(d)-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Estates, Trusts, and Beneficiaries § 1.643(d)-2...

  12. 12 CFR Appendix D-2 to Part 208 - Interagency Guidelines Establishing Information Security Standards

    Science.gov (United States)

    2010-01-01

    ... (REGULATION H) Pt. 208, App. D-2 Appendix D-2 to Part 208—Interagency Guidelines Establishing Information..., collect, store, use, transmit, protect, or dispose of customer information. g. Service provider means any... (OTS). 2 12 CFR part 30, app. B (OCC); 12 CFR part 208, app. D-2 and part 225, app. F (Board); 12 CFR...

  13. The Global Historical Climatology Network: Long-term monthly temperature, precipitation, sea level pressure, and station pressure data

    Energy Technology Data Exchange (ETDEWEB)

    Vose, R.S. [Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center; Schmoyer, R.L. [Oak Ridge National Lab., TN (United States); Steurer, P.M.; Peterson, T.C.; Heim, R.; Karl, T.R. [National Climatic Data Center, Asheville, NC (United States); Eischeid, J.K. [Colorado Univ., Boulder, CO (United States). Cooperative Inst. for Research in Environmental Sciences

    1992-07-01

    Interest in global climate change has risen dramatically during the last several years. In a similar fashion, the number of data sets available to study global change has also increased. Unfortunately, these data sets have been compiled by many different organizations/researchers, making it confusing and time consuming for individual researchers to acquire the ``best`` data. In response to this rapid growth in the number of global data sets, the Carbon Dioxide Information Analysis Center (CDIAC) and the National Climatic Data Center (NCDC) commenced the Global Historical Climatology Network (GHCN) project. The purpose of this project is to compile an improved global base-line data set of long-term monthly mean temperature, precipitation, sea level pressure, and station pressure for a dense network. of worldwide meteorological stations. Specifically, the GHCN project seeks to consolidate the numerous preexisting national-, regional-, and global-scale data sets into a single global climate data base that can be updated, enhanced, and distributed at regular intervals. The first version of the GHCN data base was completed during the summer of 1992. It contains 6039 temperature, 7533 precipitation, 1883 sea level pressure, and 1873 station pressure stations. All stations have at least 10 years of data, 40% have more than 50 years of data, and 10% have more than 100 years of data. Spatial coverage is good over most of the globe, particularly for the United States and central Europe. In comparison to other major global data sets, dramatic improvements are evident over South America, Africa, and Asia. The GHCN data base is available as a Numeric Data Package (NDP) from CDIAC. The NDP consists of this document and two magnetic tapes that contain machine-readable data files and accompanying retrieval codes. This document describes, in detail, both the GHCN data base and the contents of the magnetic tap

  14. The Global Historical Climatology Network: Long-term monthly temperature, precipitation, sea level pressure, and station pressure data

    Energy Technology Data Exchange (ETDEWEB)

    Vose, R.S. (Tennessee Univ., Knoxville, TN (United States). Energy, Environment and Resources Center); Schmoyer, R.L. (Oak Ridge National Lab., TN (United States)); Steurer, P.M.; Peterson, T.C.; Heim, R.; Karl, T.R. (National Climatic Data Center, Asheville, NC (United States)); Eischeid, J.K. (Colorado Univ., Boulder, CO (United States). Cooperative Inst. for Research in Environmental Sciences)

    1992-07-01

    Interest in global climate change has risen dramatically during the last several years. In a similar fashion, the number of data sets available to study global change has also increased. Unfortunately, these data sets have been compiled by many different organizations/researchers, making it confusing and time consuming for individual researchers to acquire the best'' data. In response to this rapid growth in the number of global data sets, the Carbon Dioxide Information Analysis Center (CDIAC) and the National Climatic Data Center (NCDC) commenced the Global Historical Climatology Network (GHCN) project. The purpose of this project is to compile an improved global base-line data set of long-term monthly mean temperature, precipitation, sea level pressure, and station pressure for a dense network. of worldwide meteorological stations. Specifically, the GHCN project seeks to consolidate the numerous preexisting national-, regional-, and global-scale data sets into a single global climate data base that can be updated, enhanced, and distributed at regular intervals. The first version of the GHCN data base was completed during the summer of 1992. It contains 6039 temperature, 7533 precipitation, 1883 sea level pressure, and 1873 station pressure stations. All stations have at least 10 years of data, 40% have more than 50 years of data, and 10% have more than 100 years of data. Spatial coverage is good over most of the globe, particularly for the United States and central Europe. In comparison to other major global data sets, dramatic improvements are evident over South America, Africa, and Asia. The GHCN data base is available as a Numeric Data Package (NDP) from CDIAC. The NDP consists of this document and two magnetic tapes that contain machine-readable data files and accompanying retrieval codes. This document describes, in detail, both the GHCN data base and the contents of the magnetic tap

  15. Reactive oxygen species-dependent hypertension in dopamine D2 receptor-deficient mice.

    Science.gov (United States)

    Armando, Ines; Wang, Xiaoyan; Villar, Van Anthony M; Jones, John E; Asico, Laureano D; Escano, Crisanto; Jose, Pedro A

    2007-03-01

    Dysfunction of D2-like receptors has been reported in essential hypertension. Disruption of D2R in mice (D2-/-) results in high blood pressure, and several D2R polymorphisms are associated with decreased D2R expression. Because D2R agonists have antioxidant activity, we hypothesized that increased blood pressure in D2-/- is related to increased oxidative stress. D2-/- mice had increased urinary excretion of 8-isoprostane, a parameter of oxidative stress; increased activity of reduced nicotinamide-adenine dinucleotide phosphate oxidase in renal cortex; increased expression of the reduced nicotinamide-adenine dinucleotide phosphate oxidase subunits Nox1, Nox2, and Nox4; and decreased expression of the antioxidant enzyme heme-oxygenase-2 in the kidneys, suggesting that regulation of reactive oxygen species (ROS) production by D2R involves both pro-oxidant and antioxidant systems. Apocynin, a reduced nicotinamide-adenine dinucleotide phosphate oxidase inhibitor, or hemin, an inducer of heme oxigenase-1, normalized the blood pressure in D2-/- mice. Because D2Rs in the adrenal gland are implicated in aldosterone regulation, we evaluated whether alterations in aldosterone secretion contribute to ROS production in this model. Urinary aldosterone was increased in D2-/- mice and its response to a high-sodium diet was impaired. Spirolactone normalized the blood pressure in D2-/- mice and the renal expression of Nox1 and Nox4, indicating that the increased blood pressure and ROS production are, in part, mediated by impaired aldosterone regulation. However, spironolactone did not normalize the excretion of 8-isoprostane and had no effect on expression of Nox2 or heme-oxygenase-2. Our results show that the D2R is involved in the regulation of ROS production and that, by direct and indirect mechanisms, altered D2R function may result in ROS-dependent hypertension.

  16. Quantifying uncertainty in climatological fields from GPS radio occultation: an empirical-analytical error model

    Directory of Open Access Journals (Sweden)

    B. Scherllin-Pirscher

    2011-05-01

    Full Text Available Due to the measurement principle of the radio occultation (RO technique, RO data are highly suitable for climate studies. Single RO profiles can be used to build climatological fields of different atmospheric parameters like bending angle, refractivity, density, pressure, geopotential height, and temperature. RO climatologies are affected by random (statistical errors, sampling errors, and systematic errors, yielding a total climatological error. Based on empirical error estimates, we provide a simple analytical error model for these error components, which accounts for vertical, latitudinal, and seasonal variations. The vertical structure of each error component is modeled constant around the tropopause region. Above this region the error increases exponentially, below the increase follows an inverse height power-law. The statistical error strongly depends on the number of measurements. It is found to be the smallest error component for monthly mean 10° zonal mean climatologies with more than 600 measurements per bin. Due to smallest atmospheric variability, the sampling error is found to be smallest at low latitudes equatorwards of 40°. Beyond 40°, this error increases roughly linearly, with a stronger increase in hemispheric winter than in hemispheric summer. The sampling error model accounts for this hemispheric asymmetry. However, we recommend to subtract the sampling error when using RO climatologies for climate research since the residual sampling error remaining after such subtraction is estimated to be 50 % of the sampling error for bending angle and 30 % or less for the other atmospheric parameters. The systematic error accounts for potential residual biases in the measurements as well as in the retrieval process and generally dominates the total climatological error. Overall the total error in monthly means is estimated to be smaller than 0.07 % in refractivity and 0.15 K in temperature at low to mid latitudes, increasing towards

  17. Algorithms for enumerating and counting D2CS of some graphs

    CERN Document Server

    Reddy, P Venkata Subba

    2010-01-01

    A D2CS of a graph G is a set $S \\subseteq V(G)$ with $diam(G[S]) \\leq 2$. We study the problem of counting and enumerating D2CS of a graph. First we give an explicit formula for the number of D2CS in a complete k-ary tree, Fibonacci tree, binary Fibonacci tree and the binomial tree. Next we give an algorithm for enumerating and counting D2CS of a graph. We then give a linear time algorithm for finding all maximal D2CS in a strongly chordal graph.

  18. Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability

    OpenAIRE

    2015-01-01

    We have used bioorthogonal click chemistry (BCC), a sensitive non-isotopic labeling method, to analyze the palmitoylation status of the D2 dopamine receptor (D2R), a G protein-coupled receptor (GPCR) crucial for regulation of processes such as mood, reward, and motor control. By analyzing a series of D2R constructs containing mutations in cysteine residues, we found that palmitoylation of the D2R most likely occurs on the C-terminal cysteine residue (C443) of the polypeptide. D2Rs in which C4...

  19. Basin-scale wind transport during the MILAGRO field campaign and comparison to climatology using cluster analysis

    Directory of Open Access Journals (Sweden)

    B. de Foy

    2007-09-01

    Full Text Available The MILAGRO field campaign was a multi-agency international collaborative project to evaluate the regional impacts of the Mexico City air pollution plume as a means of understanding urban impacts on the global climate. Mexico City lies on an elevated plateau with mountains on three sides and has complex mountain and surface-driven wind flows. This paper asks what the wind transport was in the basin during the field campaign and how representative it was of the climatology. Surface meteorology and air quality data, radiosoundings and radar wind profiler data were collected at sites in the basin and its vicinity. Cluster analysis is used to identify the dominant wind patterns both during the campaign and within the past 10 years of operational data from the warm dry season. Our analysis shows that March 2006 was representative of typical flow patterns experienced in the basin. Six episode types were identified for the basin scale circulation providing a way of interpreting atmospheric chemistry and particulate data collected during the campaign. Decoupling between surface winds and those aloft had a strong influence in leading to convection and poor air quality episodes. Hourly characterisation of wind circulation during the MILAGRO, MCMA-2003 and IMADA field campaigns will enable the comparisons of similar air pollution episodes and the evaluation of the impact of wind transport on measurements of the atmospheric chemistry taking place in the basin.

  20. Basin-scale wind transport during the MILAGRO field campaign and comparison to climatology using cluster analysis

    Directory of Open Access Journals (Sweden)

    B. de Foy

    2008-03-01

    Full Text Available The MILAGRO field campaign was a multi-agency international collaborative project to evaluate the regional impacts of the Mexico City air pollution plume as a means of understanding urban impacts on the global climate. Mexico City lies on an elevated plateau with mountains on three sides and has complex mountain and surface-driven wind flows. This paper asks what the wind transport was in the basin during the field campaign and how representative it was of the climatology. Surface meteorology and air quality data, radiosondes and radar wind profiler data were collected at sites in the basin and its vicinity. Cluster analysis was used to identify the dominant wind patterns both during the campaign and within the past 10 years of operational data from the warm dry season. Our analysis shows that March 2006 was representative of typical flow patterns experienced in the basin. Six episode types were identified for the basin-scale circulation providing a way of interpreting atmospheric chemistry and particulate data collected during the campaign. Decoupling between surface winds and those aloft had a strong influence in leading to convection and poor air quality episodes. Hourly characterisation of wind circulation during the MILAGRO, MCMA-2003 and IMADA field campaigns enables the comparisons of similar air pollution episodes and the evaluation of the impact of wind transport on measurements of the atmospheric chemistry taking place in the basin.

  1. Deformable 3D-2D registration for guiding K-wire placement in pelvic trauma surgery

    Science.gov (United States)

    Goerres, J.; Jacobson, M.; Uneri, A.; de Silva, T.; Ketcha, M.; Reaungamornrat, S.; Vogt, S.; Kleinszig, G.; Wolinsky, J.-P.; Osgood, G.; Siewerdsen, J. H.

    2017-03-01

    Pelvic Kirschner wire (K-wire) insertion is a challenging surgical task requiring interpretation of complex 3D anatomical shape from 2D projections (fluoroscopy) and delivery of device trajectories within fairly narrow bone corridors in proximity to adjacent nerves and vessels. Over long trajectories ( 10-25 cm), K-wires tend to curve (deform), making conventional rigid navigation inaccurate at the tip location. A system is presented that provides accurate 3D localization and guidance of rigid or deformable surgical devices ("components" - e.g., K-wires) based on 3D-2D registration. The patient is registered to a preoperative CT image by virtually projecting digitally reconstructed radiographs (DRRs) and matching to two or more intraoperative x-ray projections. The K-wire is localized using an analogous procedure matching DRRs of a deformably parametrized model for the device component (deformable known-component registration, or dKC-Reg). A cadaver study was performed in which a K-wire trajectory was delivered in the pelvis. The system demonstrated target registration error (TRE) of 2.1 ± 0.3 mm in location of the K-wire tip (median ± interquartile range, IQR) and 0.8 ± 1.4º in orientation at the tip (median ± IQR), providing functionality analogous to surgical tracking / navigation using imaging systems already in the surgical arsenal without reliance on a surgical tracker. The method offers quantitative 3D guidance using images (e.g., inlet / outlet views) already acquired in the standard of care, potentially extending the advantages of navigation to broader utilization in trauma surgery to improve surgical precision and safety.

  2. Low bioaccessibility of vitamin D2 from yeast-fortified bread compared to crystalline D2 bread and D3 from fluid milks.

    Science.gov (United States)

    Lipkie, Tristan E; Ferruzzi, Mario G; Weaver, Connie M

    2016-11-09

    The assessment of the efficacy of dietary and supplemental vitamin D tends to be confounded by differences in the serum 25-hydroxyvitamin D response between vitamin D2 and vitamin D3. Serum response differences from these vitamers may be due to differences in bioavailability. To address this specifically, the bioaccessibility was assessed for vitamin D2 from breads fortified with UV-treated yeast, and a benchmark against staple vitamin D3 fortified foods including bovine milks and infant formula, as well as crystalline vitamin D2 fortified bread. Fortified foods were subjected to a three-stage static in vitro digestion model, and vitamin D was analyzed by HPLC-MS. Vitamin D bioaccessibility was significantly greater from bovine milks and infant formula (71-85%) than from yeast-fortified sandwich breads (6-7%). Bioaccessibility was not different between whole wheat and white wheat bread (p > 0.05), but was ∼4× lower from yeast-fortified bread than from crystalline vitamin D2 fortified bread (p D2 in comparison to other vitamin D2 sources is likely due to entrapment within a less digestible yeast matrix and not only to metabolic differences between vitamins D2 and D3.

  3. Assessment of daily reference evapotranspiration in Sicily by means of POWER-NASA agro-climatology archive

    Science.gov (United States)

    Negm, Amro; Jabro, Jay; Provenzano, Giuseppe

    2016-04-01

    The importance of evapotranspiration, ET, processes has long been recognized in many disciplines, including hydrologic and drainage studies as well as for irrigation system design and management. A wide number of equations have been proposed to estimate crop reference evapotranspiration, ET0, based on the variables affecting the process. When a full data set of climate variables is available, the Food and Agriculture Organization (FAO) of the United Nations recommended to use the physically based FAO-56 Penman-Monteith equation. The lack of climate variables and particularly of solar radiation has led several researchers to propose simplified ET0 estimation equations using a limited number of climate variables. These equations, however, need site-specific validation prior to their use and cannot be generalized. Recently, the American National Aeronautics and Space Administration (NASA), created an efficient and open access agro-climatology archive in the frame of the Prediction Of Worldwide Energy Resource (POWER) project containing, on global scale, a long-series of meteorological variables and surface solar energy fluxes. The main objective of the research was to assess the suitability of POWER-NASA open access archive to estimate daily reference evapotranspiration, ET0, in Sicily, for the period 2006-2014. Daily ET0 were evaluated according to FAO-56 PM equation, by considering the POWER-NASA database characterized by a grid resolution of 1° latitude × 1° longitude, as well as the climate data measured on the ground, by a network of 36 meteorological stations installed in Sicily and belonging to the Agro-meteorological Information Service (SIAS). After comparing the climate data available in both databases (minimum, maximum and average air temperature and relative air humidity, wind speed, solar radiation and air pressure), a statistical comparison was also carried out on ET0 values estimated with the FAO-56 PM equation. The analysis showed a good correlation

  4. Heavy Thunderstorm Synoptic Climatology and Forcing Mechanisms in Saudi Arabia.

    Science.gov (United States)

    Ghulam, Ayman S.

    2010-05-01

    Meteorologists are required to provide accurate and comprehensive weather information for planning and operational aviation, agricultural, water projects and also for the public. In general, weather phenomena such as thunderstorms over the area between the tropics and the middle latitudes are not fully understood, particularly in the Middle East area, for many reasons such as: 1) the complexity of the nature of the climate due to the wide-ranging diversity in the topography and landscape in the area; 2) the lack of meteorological data in the area; and 3) the lack of studies on local weather situations. In arid regions such as Saudi Arabia, the spatial and temporal variation of thunderstorms and associated rainfall are essential in determining their effects on social and economic conditions. Thunderstorms form rapidly, due to the fact that the significant heating of the air from the surface and the ensuing rainfall usually occurs within a short period of time. Thus, understanding thunderstorms and rainfall distribution in time and space would be useful for hydrologists, meteorologists and for environmental studies. Research all over the world has shown, however, that consideration of local factors like Low Level Jets (LLJ), moisture flux, sea breezes, and the Red Sea Convergence Zone (RSCZ) would be valuable in thunderstorm prediction. The combined effects of enhanced low-level moisture convergence and layer destabilization due to upslope flow over mountainous terrain has been shown to be responsible for thunderstorm development in otherwise non-favourable conditions. However, there might be other synoptic features associated with heavy thunderstorms or cause them, but these features have not been investigated in any research in Saudi Arabia. Thus, relating the local weather and synoptic situations with those over the middle latitudes will provide a valuable background for the forecasters to issue the medium-range forecasts which are important for many projects

  5. Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes.

    Science.gov (United States)

    Borroto-Escuela, Dasiel O; Romero-Fernandez, Wilber; Narvaez, Manuel; Oflijan, Julia; Agnati, Luigi F; Fuxe, Kjell

    2014-01-03

    Dopamine D2LR-serotonin 5-HT2AR heteromers were demonstrated in HEK293 cells after cotransfection of the two receptors and shown to have bidirectional receptor-receptor interactions. In the current study the existence of D2L-5-HT2A heteroreceptor complexes was demonstrated also in discrete regions of the ventral and dorsal striatum with in situ proximity ligation assays (PLA). The hallucinogenic 5-HT2AR agonists LSD and DOI but not the standard 5-HT2AR agonist TCB2 and 5-HT significantly increased the density of D2like antagonist (3)H-raclopride binding sites and significantly reduced the pKiH values of the high affinity D2R agonist binding sites in (3)H-raclopride/DA competition experiments. Similar results were obtained in HEK293 cells and in ventral striatum. The effects of the hallucinogenic 5-HT2AR agonists on D2R density and affinity were blocked by the 5-HT2A antagonist ketanserin. In a forskolin-induced CRE-luciferase reporter gene assay using cotransfected but not D2R singly transfected HEK293 cells DOI and LSD but not TCB2 significantly enhanced the D2LR agonist quinpirole induced inhibition of CRE-luciferase activity. Haloperidol blocked the effects of both quinpirole alone and the enhancing actions of DOI and LSD while ketanserin only blocked the enhancing actions of DOI and LSD. The mechanism for the allosteric enhancement of the D2R protomer recognition and signalling observed is likely mediated by a biased agonist action of the hallucinogenic 5-HT2AR agonists at the orthosteric site of the 5-HT2AR protomer. This mechanism may contribute to the psychotic actions of LSD and DOI and the D2-5-HT2A heteroreceptor complex may thus be a target for the psychotic actions of hallunicogenic 5-HT2A agonists. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Dopamine-induced apoptosis of lactotropes is mediated by the short isoform of D2 receptor.

    Directory of Open Access Journals (Sweden)

    Daniela Betiana Radl

    Full Text Available Dopamine, through D2 receptor (D2R, is the major regulator of lactotrope function in the anterior pituitary gland. Both D2R isoforms, long (D2L and short (D2S, are expressed in lactotropes. Although both isoforms can transduce dopamine signal, they differ in the mechanism that leads to cell response. The administration of D2R agonists, such as cabergoline, is the main pharmacological treatment for prolactinomas, but resistance to these drugs exists, which has been associated with alterations in D2R expression. We previously reported that dopamine and cabergoline induce apoptosis of lactotropes in primary culture in an estrogen-dependent manner. In this study we used an in vivo model to confirm the permissive action of estradiol in the apoptosis of anterior pituitary cells induced by D2R agonists. Administration of cabergoline to female rats induced apoptosis, measured by Annexin-V staining, in anterior pituitary gland from estradiol-treated rats but not from ovariectomized rats. To evaluate the participation of D2R isoforms in the apoptosis induced by dopamine we used lactotrope-derived PR1 cells stably transfected with expression vectors encoding D2L or D2S receptors. In the presence of estradiol, dopamine induced apoptosis, determined by ELISA and TUNEL assay, only in PR1-D2S cells. To study the role of p38 MAPK in apoptosis induced by D2R activation, anterior pituitary cells from primary culture or PR1-D2S were incubated with an inhibitor of the p38 MAPK pathway (SB203850. SB203580 blocked the apoptotic effect of D2R activation in lactotropes from primary cultures and PR1-D2S cells. Dopamine also induced p38 MAPK phosphorylation, determined by western blot, in PR1-D2S cells and estradiol enhanced this effect. These data suggest that, in the presence of estradiol, D2R agonists induce apoptosis of lactotropes by their interaction with D2S receptors and that p38 MAPK is involved in this process.

  7. Known-component 3D-2D registration for image guidance and quality assurance in spine surgery pedicle screw placement

    Science.gov (United States)

    Uneri, A.; Stayman, J. W.; De Silva, T.; Wang, A. S.; Kleinszig, G.; Vogt, S.; Khanna, A. J.; Wolinsky, J.-P.; Gokaslan, Z. L.; Siewerdsen, J. H.

    2015-03-01

    Purpose. To extend the functionality of radiographic / fluoroscopic imaging systems already within standard spine surgery workflow to: 1) provide guidance of surgical device analogous to an external tracking system; and 2) provide intraoperative quality assurance (QA) of the surgical product. Methods. Using fast, robust 3D-2D registration in combination with 3D models of known components (surgical devices), the 3D pose determination was solved to relate known components to 2D projection images and 3D preoperative CT in near-real-time. Exact and parametric models of the components were used as input to the algorithm to evaluate the effects of model fidelity. The proposed algorithm employs the covariance matrix adaptation evolution strategy (CMA-ES) to maximize gradient correlation (GC) between measured projections and simulated forward projections of components. Geometric accuracy was evaluated in a spine phantom in terms of target registration error at the tool tip (TREx), and angular deviation (TREΦ) from planned trajectory. Results. Transpedicle surgical devices (probe tool and spine screws) were successfully guided with TREx30° (easily accommodated on a mobile C-arm). QA of the surgical product based on 3D-2D registration demonstrated the detection of pedicle screw breach with TRExConclusions. 3D-2D registration combined with 3D models of known surgical components provides a novel method for near-real-time guidance and quality assurance using a mobile C-arm without external trackers or fiducial markers. Ongoing work includes determination of optimal views based on component shape and trajectory, improved robustness to anatomical deformation, and expanded preclinical testing in spine and intracranial surgeries.

  8. Quality Control of ARGO Data Based on Climatological T-S Models

    Institute of Scientific and Technical Information of China (English)

    纪风颖; 林绍花

    2004-01-01

    By implementing the ARGO program, a large number of T-S profiles can be observed in the world ocean. However, it is very difficult to examine changes of the sensitivity of the sensors equipped at the ARGO floats, because it is difficult to understand their condition in the sea and the reliability of the data. Quality control must be done in order to avoid the wrong conclusion deduced from the wrong data.One of the realistic methods for quality control of the ARGO data is the comparison with the local climatology. High quality climatological T-S models in northwest Pacific have been built based on the Nansen bottle data and CTD data for the quality control in NMDIS. The models are used to check the ARGO data in this area and have got good result.

  9. Dependence of model-simulated response to ozone depletion on stratospheric polar vortex climatology

    Science.gov (United States)

    Lin, Pu; Paynter, David; Polvani, Lorenzo; Correa, Gustavo J. P.; Ming, Yi; Ramaswamy, V.

    2017-06-01

    We contrast the responses to ozone depletion in two climate models: Community Atmospheric Model version 3 (CAM3) and Geophysical Fuild Dynamics Laboratory (GFDL) AM3. Although both models are forced with identical ozone concentration changes, the stratospheric cooling simulated in CAM3 is 30% stronger than in AM3 in annual mean, and twice as strong in December. We find that this difference originates from the dynamical response to ozone depletion, and its strength can be linked to the timing of the climatological springtime polar vortex breakdown. This mechanism is further supported by a variant of the AM3 simulation in which the southern stratospheric zonal wind climatology is nudged to be CAM3-like. Given that the delayed breakdown of the southern polar vortex is a common bias among many climate models, previous model-based assessments of the forced responses to ozone depletion may have been somewhat overestimated.

  10. The climatology of the Red Sea - part 2: the waves

    KAUST Repository

    Langodan, Sabique

    2017-05-09

    The wave climatology of the Red Sea is described based on a 30-year hindcast generated using WAVEWATCH III configured on a 5-km resolution grid and forced by Red Sea reanalysis surface winds from the advanced Weather Research and Forecasting model. The wave simulations have been validated using buoy and altimeter data. The four main wind systems in the Red Sea characterize the corresponding wave climatology. The dominant ones are the two opposite wave systems with different genesis, propagating along the axis of the basin. The highest waves are generated at the centre of the Red Sea as a consequence of the strong seasonal winds blowing from the Tokar Gap on the African side. There is a general long-term trend toward lowering the values of the significant wave height over the whole basin, with a decreasing rate depending on the genesis of the individual systems.

  11. Toward the climatological study of polar lows over the Japan Sea

    Science.gov (United States)

    Yanase, Wataru

    2014-05-01

    Satellite imagery shows that meso-alpha-scale polar lows develop over the Japan Sea during cold air outbreaks in winter, which usually occur to the west of synoptic-scale extratropical cyclones. To understand the climatology of polar lows over the Japan Sea, we use satellite imagery and a reanalysis dataset. We used nephanalysis charts of the Japan Meteorological Agency, which shows 3-hourly locations of lower-tropospheric meso-scale vortices. For 6 winter seasons (Dec. 1997 - Feb. 2003), 81 polar low candidates are detected over the Japan Sea. We will show the geographical distribution and some remarkable polar low cases. We also examine whether the Japanese 55-year reanalysis (JRA-55) is useful for the climatological study of polar lows. The sea level pressure field of JRA-55 represents signals of intense polar lows. The spatial filter for meso-scale cyclones and tracking algorithm of Hodges (1995) successfully detected intense polar lows over the Japan Sea.

  12. The bioclimatological leaflet as a means conveying climatological information to tourists and the tourism industry

    Science.gov (United States)

    Zaninović, Ksenija; Matzarakis, Andreas

    2009-07-01

    Climate is an important resource for tourism and must be taken into account in tourism promotions. Here, a climate leaflet containing climatological and bioclimatological information for tourists is presented. The bioclimatological conditions are portrayed using mean values and frequency of thermal sensation based on physiologically equivalent temperature for 10-day intervals covering the whole year, along with air and sea temperature, sunshine duration, amount and number of days with precipitation and wind roses. In addition, the Climate Tourism Information Scheme is included. When combined with climatological and bioclimatological conditions, this scheme is valuable for tourists as it enables them to choose the most suitable time period for holidays, with the choice depending on personal preferences and requirements. The information provided here assists the tourism industry and stakeholders in decision-making. As an example, the bioclimatological leaflet for Hvar, an island off the Croatian Adriatic coast, is presented.

  13. A climatological analysis of high-precipitation events in Dronning Maud Land, Antarctica, and associated large-scale atmospheric conditions

    Science.gov (United States)

    Welker, Christoph; Martius, Olivia; Froidevaux, Paul; Reijmer, Carleen H.; Fischer, Hubertus

    2015-04-01

    Dronning Maud Land (DML), located in the Atlantic sector of East Antarctica, has become an area of intensive ice core research in recent years. Ice cores are used to study past climatic changes among others. To correctly interpret the ice core information, a profound understanding of the glaciological processes that lead to ice sheet formation as well as of the atmospheric conditions under which snow accumulation occurs is indispensable. Earlier studies showed that in DML especially high-precipitation events complicate the interpretation of ice core data. The atmospheric conditions leading to high precipitation in DML have been widely investigated, however these investigations tended to focus on individual case studies. Our main objective in this study is to analyse the link between high precipitation in DML and the large-scale atmospheric conditions from a climatological perspective. High-precipitation events are analysed at Halvfarryggen ice dome (71.2°S, 6.7°W), a potential ice core drilling site situated in the relatively wet, low-altitude coastal region of DML, and at Kohnen Station (75°S, 0.1°E), a deep ice core drilling site located in DML's dry, high-altitude interior. For our climatological analysis, we primarily make use of atmospheric reanalysis data from the ERA-Interim project for 1979-2009; complemented by precipitation data from the Antarctic Mesoscale Prediction System and snow accumulation measurements from automatic weather stations located near Halvfarryggen and Kohnen Station. To describe the large-scale atmospheric conditions, we focus on vertically integrated water vapour transport (IVT), upper level potential vorticity, surface cyclone frequency, and atmospheric blocking frequency. In line with earlier studies, we find that high-precipitation events in DML are typically associated with amplified upper level waves. This large-scale atmospheric flow pattern is preceded by the downstream development of a Rossby wave train from the eastern

  14. Dust Climatology of the NASA Dryden Flight Research Center (DFRC) in Lancaster, California, USA

    OpenAIRE

    Ashok K. Pokharel; Michael L. Kaplan

    2017-01-01

    Abstract: A 15-year (1997–2011) climatology of dust events at the NASA DFRC in Lancaster, California, USA, was performed to evaluate how the extratropical systems were associated with dust storms over this region. For this study, we collected meteorological data for Edwards Air Force Base (EAFB) in Lancaster, California, which is very close to NASA DFRC, from wunderground.com, National Centers for Environmental Prediction (NCEP)/North American Regional Reanalysis (NARR), NCEP/Hydro-meteorolog...

  15. Merged dust climatology in Phoenix, Arizona based on satellite and station data

    Science.gov (United States)

    Lei, Hang; Wang, Julian X. L.; Tong, Daniel Q.; Lee, Pius

    2016-11-01

    In order to construct climate quality long-term dust storm dataset, merged dust storm climatology in Phoenix is developed based on three data sources: regular meteorological records, in situ air quality measurements, and satellite remote sensing observations. The result presented in this paper takes into account the advantages of each dataset and integrates individual analyses demonstrated and presented in previous studies that laid foundation to reconstruct a consistent and continuous time series of dust frequency. A key for the merging procedure is to determine analysis criteria suitable for each individual data source. A practical application to historic records of dust storm activities over the Phoenix area is presented to illustrate detailed steps, advantages, and limitations of the newly developed process. Three datasets are meteorological records from the Sky Harbor station, satellite observed aerosol optical depth data from moderate resolution imaging spectroradiometer, and the U.S. Environmental Protection Agency Air Quality System particulate matter data of eight sites surrounding Phoenix. Our purpose is to construct dust climatology over the Phoenix region for the period 1948-2012. Data qualities of the reconstructed dust climatology are assessed based on the availability and quality of the input data. The period during 2000-2012 has the best quality since all datasets are well archived. The reconstructed climatology shows that dust storm activities over the Phoenix region have large interannual variability. However, seasonal variations show a skewed distribution with higher frequency of dust storm activities in July and August and relatively quiet during the rest of months. Combining advantages of all the available datasets, this study presents a merged product that provides a consistent and continuous time series of dust storm activities suitable for climate studies.

  16. An Update to the Warm-Season Convective Wind Climatology of KSC/CCAFS

    Science.gov (United States)

    Lupo, Kevin

    2012-01-01

    Total of 1100 convective events in the 17-year warm-season climatology at KSC/CCAFS. July and August typically are the peak of convective events, May being the minimum. Warning and non-warning level convective winds are more likely to occur in the late afternoon (1900-2000Z). Southwesterly flow regimes and wind directions produce the strongest winds. Storms moving from southwesterly direction tend to produce more warning level winds than those moving from the northerly and easterly directions.

  17. Comparison of high-latitude thermospheric meridional winds II: combined FPI, radar and model climatologies

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, E.M.; Aruliah, A.; Mueller-Wodarg, I.C.F.; Aylward, A. [Atmospheric Physics Lab., Univ. Coll. London, London (United Kingdom)

    2004-07-01

    The climatological behaviour of the thermospheric meridional wind above Kiruna, Sweden (67.4 N, 20.4 E) has been investigated for seasonal and solar cycle dependence using six different techniques, comprising both model and experimental sources. Model output from both the empirical Horizontal Wind Model (HWM) (Hedin et al., 1988) and the numerical coupled thermosphere and ionosphere model (CTIM) are compared to the measured behaviour at kiruna, as a single site example. The empirical International Reference Ionosphere (IRI) model is used as input to an implementation of servo theory, to provide another climatology combining empirical input with a theoretical framework. The experimental techniques have been introduced in a companion paper in this issue and provide climatologies from direct measurements, using fabry-perot interferometers (FPI), together with 2 separate techniques applied to the European incoherent scatter radar (EISCAT) database to derive neutral winds. One of these techniques uses the same implementation of servo theory as has been used with the IRI model. Detailed comparisons for each season and solar activity category allow for conclusions to be drawn as to the major influences on the climatological behaviour of the wind at this latitude. Comparison of the incoherent scatter radar (ISR) derived neutral winds with FPI, empirical model and numerical model winds is important to our understanding and judgement of the validity of the techniques used to derive thermospheric wind databases. The comparisons also test model performance and indicate possible reasons for differences found between the models. In turn, the conclusions point to possible improvements in their formulation. In particular it is found that the empirical models are over-reliant on mid-latitude data in their formulation, and fail to provide accurate estimates of the winds at high-latitudes. (orig.)

  18. Comparison of high-latitude thermospheric meridionalwinds II: combined FPI, radar and model Climatologies

    Directory of Open Access Journals (Sweden)

    E. M. Griffin

    2004-03-01

    Full Text Available The climatological behaviour of the thermospheric meridional wind above Kiruna, Sweden (67.4°N, 20.4°E has been investigated for seasonal and solar cycle dependence using six different techniques, comprising both model and experimental sources. Model output from both the empirical Horizontal Wind Model (HWM (Hedin et al., 1988 and the numerical Coupled Thermosphere and Ionosphere Model (CTIM are compared to the measured behaviour at Kiruna, as a single site example. The empirical International Reference Ionosphere (IRI model is used as input to an implementation of servo theory, to provide another climatology combining empirical input with a theoretical framework. The experimental techniques have been introduced in a companion paper in this issue and provide climatologies from direct measurements, using Fabry-Perot Interferometers (FPI, together with 2 separate techniques applied to the European Incoherent Scatter radar (EISCAT database to derive neutral winds. One of these techniques uses the same implementation of servo theory as has been used with the IRI model. Detailed comparisons for each season and solar activity category allow for conclusions to be drawn as to the major influences on the climatological behaviour of the wind at this latitude. Comparison of the incoherent scatter radar (ISR derived neutral winds with FPI, empirical model and numerical model winds is important to our understanding and judgement of the validity of the techniques used to derive thermospheric wind databases. The comparisons also test model performance and indicate possible reasons for differences found between the models. In turn, the conclusions point to possible improvements in their formulation. In particular it is found that the empirical models are over-reliant on mid-latitude data in their formulation, and fail to provide accurate estimates of the winds at high-latitudes.

    Key words. Meteorology and atmospheric dynamics (thermospheric dynamics

  19. Assessment of North Atlantic Precipitation and Freshwater Flux from the HOAPS-3 satellite climatology

    Science.gov (United States)

    Andersson, A.; Klepp, C.; Bakan, S.; Schulz, J.

    2009-04-01

    To attain a better understanding and modeling of climate processes attaining a proper knowledge of global water cycle components is essential. For the assessment of the freshwater flux at the ocean surface on global scale, exchange processes at the air-sea interface play a key-role. With the ability to derive ocean latent heat flux and precipitation from satellite data with acceptable accuracy, and frequent global coverage, a climatological assessment of the crucial processes has become possible. The HOAPS-3 climatology (Hamburg Ocean Atmosphere Parameters and Fluxes from Satellite Data) contains fields of precipitation, surface fluxes and atmospheric parameters over the global ice-free ocean between 1987 and 2005. Except for the NOAA Pathfinder SST, all basic state variables needed for the derivation of the fluxes are calculated from SSM/I passive microwave radiometer measurements. Multi-satellite averages, inter-sensor calibration, and an efficient sea ice detection procedure make HOAPS a suitable data set for climatological applications as well as for case studies. Gridded 0.5 degree monthly, pentad and twice daily data products are freely available from www.hoaps.org. For the precipitation parameter, quasi-global coverage is achieved by complementing HOAPS-3 over land areas using the rain gauge based "Full Data Reanalysis Product Version 4", which is provided by the Global Precipitation Climatology Centre (GPCC). North Atlantic intra-decadal precipitation variability is investigated using this combined data set. The mutual response of the two independent precipitation data sources to the North Atlantic Oscillation (NAO) reveals coherent patterns and a detailed view on the structural changes in precipitation during the high and low states of the NAO. A second focus will be put on the evaluation of HOAPS-3 ocean surface freshwater fluxes and their interaction with the NAO.

  20. A map-based South Pacific rainfall climatology

    Science.gov (United States)

    Lorrey, A.; Diamond, H.; Renwick, J.; Salinger, J.; Gergis, J.; Dalu, G.

    2008-12-01

    The lives of more than four million people that reside in the South Pacific are greatly affected by rainfall variability. This region is subjected to large rainfall anomalies on seasonal timescales due to tropical cyclone occurrences, ENSO activity, and the AAO. Regional climate anomalies are also dictated by the IPO on multi- decadal scales that alter the motions of large-scale circulation features like the South Pacific Convergence Zone (SPCZ). Strong climate change impacts are anticipated for this region, so gauging the severity of rainfall variations that can occur are paramount for implementing appropriate climate change adaptation measures. Lack of historical rainfall records and documentation of other climate data hinders our current understanding of South Pacific climate variability. Climate data rescue activities are currently aimed at recovering, archiving, and digitising this information to rectify this issue. This research aims to examine the rainfall database administered by the Island Climate Update (ICU) project, which is contributed to by all Pacific Island national meteorological services (NMS), Meteo-France (New Caledonia and French Polynesia), NIWA (New Zealand), NOAA (USA), the IRI (USA), and the Bureau of Meteorology (Australia). Monthly rainfall totals for all stations in the ICU database were assessed, and allowed construction of master rainfall chronologies for all or portions of the major South Pacific Island nations. Climatic norms were then calculated over common time periods, and monthly-resolved rainfall anomaly maps for the South Pacific covering 1951-2008 were undertaken. Immediate benefits of this exercise have pointed out holes in the rainfall network that can be specifically targeted for data rescue in the near future, which can be achieved by providing financial assistance to Pacific Island NMSs. In addition, there is ample scope to extend the rainfall anomaly map time series into the early 1900s using a spatially degraded data

  1. A Climatology of Tropospheric CO over the Central and Southeastern United States and the Southwestern Pacific Ocean Derived from Space, Air, and Ground-based Infrared Interferometer Spectra

    Science.gov (United States)

    McMillian, W. Wallace; Strow, L. Larrabee; Revercomb, H.; Knuteson, R.; Thompson, A.

    2003-01-01

    This final report summarizes all research activities and publications undertaken as part of NASA Atmospheric Chemistry and Modeling Analysis Program (ACMAP) Grant NAG-1-2022, 'A Climatology of Tropospheric CO over the Central and Southeastern United States and the Southwestern Pacific Ocean Derived from Space, Air, and Ground-based Infrared Interferometer Spectra'. Major project accomplishments include: (1) analysis of more than 300,000 AERI spectra from the ARM SGP site yielding a 5-year (1998-2002) timeseries of CO retrievals from the Lamont, OK AERI; (2) development of a prototype CO profile retrieval algorithm for AERI spectra; (3) validation and publication of the first CO retrievals from the Scanning High-resolution Interferometer Sounder (SHIS); and (4) development of a prototype AERI tropospheric O3 retrieval algorithm. Compilation and publication of the 5-year Lamont, OK timeseries is underway including a new collaboration with scientists at the Lawrence Berkeley National Laboratory. Public access to this data will be provided upon article submission. A comprehensive CO analysis of the archive of HIS spectra of remains as the only originally proposed activity with little progress. The greatest challenge faced in this project was motivating the University of Wisconsin Co-Investigators to deliver their archived HIS and AERIOO data along with the requisite temperature and water vapor profiles in a timely manner. Part of the supplied HIS dataset from ASHOE may be analyzed as part of a Master s Thesis under a separate project. Our success with the SAFARI 2000 SHIS CO analysis demonstrates the utility of such aircraft remote sensing data given the proper support from the instrument investigators. In addition to the PI and Co-I s, personnel involved in this CO climatology project include one Post Doctoral Fellow, one Research Scientist, two graduate students, and two undergraduate students. A total of fifteen presentations regarding research related to this

  2. Post-disaster climatology for hurricanes and tornadoes in the United States: 2000-2009

    Science.gov (United States)

    Eakins, Benjamin James

    Natural disasters can be very devastating to the public during their impact phase. After a natural disaster impacts a region, the response and recovery phases begin immediately. Weather conditions may interrupt emergency response and recovery in the days following the disaster. This study analyzes the climatology of weather conditions during the response and recovery phases of hurricanes and tornadoes to understand how weather may impact both environment and societal needs. Using specific criteria, 66 tornadoes and 16 hurricane cases were defined. National Weather Service (NWS) recognized weather stations were used to provide temperature, precipitation, snowfall, relative humidity, wind speed, and wind direction data. Regional and temporal groups were defined for tornado cases, but only one group was defined for hurricanes. By applying statistical analysis to weather observations taken in the week following the disasters, a climatology was developed for the response and recovery phase. Tornado and hurricane post-disaster climate closely mimicked their synoptic climatology with cooler and drier weather prevailing in days 2-4 after a disaster until the next weather system arrived about 5 days later. Winter tornadoes trended to occur in the Southeast and were associated with more extreme temperature differences than in other regions and season. The results of this study may help governmental and non-governmental organizations prepare for weather conditions during the post-disaster phase.

  3. [An Archive for Science, State and Nation : Climatological Data Practices in Switzerland, 1860-1914].

    Science.gov (United States)

    Hupfer, Franziska

    2017-09-27

    In the second half of the nineteenth century, most European countries began to finance weather observation networks. As a result, climatological data practices changed fundamentally. Using the example of Switzerland, this paper examines the political, institutional and methodological dimensions of national data archives. The institutionalization of data collection within the national framework meant, on the one hand, that more observations were systematically made and published. On the other hand, it also meant that the monitoring was connected to state boundaries. However, based on their universalistic conception of science, this did not preclude national institutions from striving for international data standardization. The national framework also shaped the process of transforming weather observations into statistical data. This information formed the basis for national climatographies and thus had a nation-building effect. According to the Swiss Meteorological Institute, climate data were practically useful and had great potential for research work. However, the epistemic status of data collection was uncertain, since physical approaches to climatology had gained in importance. The anticipation of scientific and practical potential benefits played a central role for the continuation of data production. The Swiss case study presented here illustrates that climatology was transformed by the process of nation-building, affecting its institutional structure, spatial references, and epistemology.

  4. A Global Climatology of Tropospheric and Stratospheric Ozone Derived from Aura OMI and MLS Measurements

    Science.gov (United States)

    Ziemke, J.R.; Chandra, S.; Labow, G.; Bhartia, P. K.; Froidevaux, L.; Witte, J. C.

    2011-01-01

    A global climatology of tropospheric and stratospheric column ozone is derived by combining six years of Aura Ozone Monitoring Instrument (OMI) and Microwave Limb Sounder (MLS) ozone measurements for the period October 2004 through December 2010. The OMI/MLS tropospheric ozone climatology exhibits large temporal and spatial variability which includes ozone accumulation zones in the tropical south Atlantic year-round and in the subtropical Mediterranean! Asia region in summer months. High levels of tropospheric ozone in the northern hemisphere also persist in mid-latitudes over the eastern North American and Asian continents extending eastward over the Pacific Ocean. For stratospheric ozone climatology from MLS, largest ozone abundance lies in the northern hemisphere in the latitude range 70degN-80degN in February-April and in the southern hemisphere around 40degS-50degS during months August-October. The largest stratospheric ozone abundances in the northern hemisphere lie over North America and eastern Asia extending eastward across the Pacific Ocean and in the southern hemisphere south of Australia extending eastward across the dateline. With the advent of many newly developing 3D chemistry and transport models it is advantageous to have such a dataset for evaluating the performance of the models in relation to dynamical and photochemical processes controlling the ozone distributions in the troposphere and stratosphere.

  5. Hybrid 3D-2D printing for bone scaffolds fabrication

    Science.gov (United States)

    Seleznev, V. A.; Prinz, V. Ya

    2017-02-01

    It is a well-known fact that bone scaffold topography on micro- and nanometer scale influences the cellular behavior. Nano-scale surface modification of scaffolds allows the modulation of biological activity for enhanced cell differentiation. To date, there has been only a limited success in printing scaffolds with micro- and nano-scale features exposed on the surface. To improve on the currently available imperfect technologies, in our paper we introduce new hybrid technologies based on a combination of 2D (nano imprint) and 3D printing methods. The first method is based on using light projection 3D printing and simultaneous 2D nanostructuring of each of the layers during the formation of the 3D structure. The second method is based on the sequential integration of preliminarily created 2D nanostructured films into a 3D printed structure. The capabilities of the developed hybrid technologies are demonstrated with the example of forming 3D bone scaffolds. The proposed technologies can be used to fabricate complex 3D micro- and nanostructured products for various fields.

  6. Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1.

    Science.gov (United States)

    Hayashi, Keiko; Yasuda, Kaori; Yogo, Yuya; Takita, Teisuke; Yasukawa, Kiyoshi; Ohta, Miho; Kamakura, Masaki; Ikushiro, Shinichi; Sakaki, Toshiyuki

    2016-05-13

    Our previous studies revealed that the double variants of CYP105A1- R73A/R84A and R73V/R84A-show high levels of activity with respect to conversion of vitamin D3 to its biologically active form, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). In this study, we found that both the double variants were also capable of converting vitamin D2 to its active form, that is, 1α,25-dihydroxyvitamin D2 (1α,25(OH)2D2), via 25(OH)D2, whereas its 1α-hydroxylation activity toward 25(OH)D2 was much lower than that toward 25(OH)D3. Comparison of the wild type and the double variants revealed that the amino acid substitutions remarkably enhanced both 25- and 26-hydroxylation activity toward vitamin D2. After 25-hydroxylation of vitamin D2, further hydroxylation at C26 may occur frequently without the release of 25(OH)D2 from the substrate-binding pocket. Thus, the double variants of CYP105A1 are quite useful to produce 25,26(OH)2D2 that is one of the metabolites of vitamin D2 detected in human serum.

  7. Blockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord

    Science.gov (United States)

    Dai, Wen-Ling; Xiong, Feng; Yan, Bing; Cao, Zheng-Yu; Liu, Wen-Tao; Liu, Ji-Hua; Yu, Bo-Yang

    2016-01-01

    Tolerance induced by morphine remains a major unresolved problem and significantly limits its clinical use. Recent evidences have indicated that dopamine D2 receptor (D2DR) is likely to be involved in morphine-induced antinociceptive tolerance. However, its exact effect and molecular mechanism remain unknown. In this study we examined the effect of D2DR on morphine antinociceptive tolerance in mice spinal cord. Chronic morphine treatment significantly increased levels of D2DR in mice spinal dorsal horn. And the immunoreactivity of D2DR was newly expressed in neurons rather than astrocytes or microglia both in vivo and in vitro. Blockade of D2DR with its antagonist (sulpiride and L-741,626, i.t.) attenuated morphine antinociceptive tolerance without affecting basal pain perception. Sulpiride (i.t.) also down-regulated the expression of phosphorylation of NR1, PKC, MAPKs and suppressed the activation of astrocytes and microglia induced by chronic morphine administration. Particularly, D2DR was found to interact with μ opioid receptor (MOR) in neurons, and chronic morphine treatment enhanced the MOR/D2DR interactions. Sulpiride (i.t.) could disrupt the MOR/D2DR interactions and attenuate morphine tolerance, indicating that neuronal D2DR in the spinal cord may be involved in morphine tolerance possibly by interacting with MOR. These results may present new opportunities for the treatment and management of morphine-induced antinociceptive tolerance which often observed in clinic. PMID:28004735

  8. Flap loop of GluD2 binds to Cbln1 and induces presynaptic differentiation.

    Science.gov (United States)

    Kuroyanagi, Tomoaki; Hirano, Tomoo

    2010-07-30

    Glutamate receptor delta2 (GluD2) is selectively expressed on the postsynaptic spines at parallel-fiber (PF)-Purkinje neuron (PN) synapses. GluD2 knockout mice show a reduced number of PF-PN synapses, suggesting that GluD2 is involved in synapse formation. Recent studies revealed that GluD2 induces presynaptic differentiation in a manner dependent on its N-terminal domain (NTD) through binding of Cbln1 secreted from cerebellar granule neurons. However, the underlying mechanism of the specific binding of the NTD to Cbln1 remains elusive. Here, we have identified the flap loop (Arg321-Trp339) in the NTD of GluD2 (GluD2-NTD) as a crucial region for the binding to Cbln1 and the induction of presynaptic differentiation. Both induction of presynaptic differentiation and binding of Cbln1 were abolished in the HEK cells expressing not wild-type GluD2 but GluD2 with mutations in the flap loop. Especially, single amino acid substitution of either Arg321 or Trp323 to alanine was sufficient to disable the GluD2 function. Finally, a homology model of GluD2-NTD suggested that the flap loop is located at the distal end, which appears consistent with an interaction with Cbln1 and a presynaptic varicosity.

  9. Cyclin D2 is sufficient to drive beta cell self-renewal and regeneration.

    Science.gov (United States)

    Tschen, Shuen-Ing; Zeng, Chun; Field, Loren; Dhawan, Sangeeta; Bhushan, Anil; Georgia, Senta

    2017-08-01

    Diabetes results from an inadequate mass of functional beta cells, due to either beta cell loss caused by autoimmune destruction (Type I diabetes) or beta cell failure in response to insulin resistance (Type II diabetes). Elucidating the mechanisms that regulate beta cell mass may be key to developing new techniques that foster beta cell regeneration as a cellular therapy to treat diabetes. While previous studies concluded that cyclin D2 is required for postnatal beta cell self-renewal in mice, it is not clear if cyclin D2 is sufficient to drive beta cell self-renewal. Using transgenic mice that overexpress cyclin D2 specifically in beta cells, we show that cyclin D2 overexpression increases beta cell self-renewal post-weaning and results in increased beta cell mass. Beta cells that overexpress cyclin D2 are responsive to glucose stimulation, suggesting they are functionally mature. Beta cells that overexpress cyclin D2 demonstrate an enhanced regenerative capacity after injury induced by streptozotocin toxicity. To understand if cyclin D2 overexpression is sufficient to drive beta cell self-renewal, we generated a novel mouse model where cyclin D2 is only expressed in beta cells of cyclin D2(-/-) mice. Transgenic overexpression of cyclin D2 in cyclin D2(-)(/)(-) beta cells was sufficient to restore beta cell mass, maintain normoglycaemia, and improve regenerative capacity when compared to cyclin D2(-/-) littermates. Taken together, our results indicate that cyclin D2 is sufficient to regulate beta cell self-renewal and that manipulation of its expression could be used to enhance beta cell regeneration.

  10. Development of an Extratropical Storm Wind, Wave, and Water Level Climatology for the Offshore Mid-Atlantic

    Science.gov (United States)

    2015-08-01

    ER D C/ CH L TR -1 5- 11 Development of an Extratropical Storm Wind , Wave, and Water Level Climatology for the Offshore Mid-Atlantic...Development of an Extratropical Storm Wind , Wave, and Water Level Climatology for the Offshore Mid-Atlantic Michael F. Forte Field Research Facility...of the extreme offshore wind , wave, and water level climate in the mid-Atlantic region has been conducted for the U.S. Bureau of Safety and

  11. Effects of time-series length and gauge network density on rainfall climatology estimates in Latin America

    OpenAIRE

    MAEDA EDUARDO EIJI; AREVALO TORRES JUAN; CARMONA MORENO Cesar

    2012-01-01

    Despite recent advances in the development of satellite sensors for monitoring precipitation at high spatial and temporal resolutions, the assessment of rainfall climatology still relies strongly on ground-station measurements. The Global Historical Climatology Network (GHCN) is one of the most popular stations database available for the international community. Nevertheless, the spatial distribution of these stations is not always homogeneous and the record length largely varies for each sta...

  12. Cross sections for ion production in reactions of H+ with D2; Effects of vibrational and rotational excited states of D2

    OpenAIRE

    市原 晃; 岩本 修; 横山 啓一

    1998-01-01

    H+とD2の反応で生じるD2+,D+及びHD+イオン生成の断面積を、重心衝突エネルギーEcm=2.5-8.0eVの範囲内で、非経験的分子軌道計算で得られたH3+の3次元ポテンシャル面上でのトラジェクトリーサーフェスホッピング(TSH)法を用いることにより、評価した。反応物D2の初期状態が各イオン生成に与える影響を調べるために、D2の振動及び回転の量子数をv=0-3,j=1,5,10に設定して計算を行った。その結果、D2+イオンの生成は、D2の振動回転状態(v,j)が高くなるに従って著しく増大することが分かった。D2+生成の飛躍的な増大には、D2の振動励起が主要な役割を果たし、回転励起は補助的な効果を与えた。D2+生成と比較して、D2の振動状態がD+及びHD+イオンの生成に与える効果は一桁小さく、D2の回転状態に対する効果は殆ど無視しうる大きさであった。...

  13. 多巴胺D2受体的同源模建研究%Homology modeling of Dopamine D2 receptor

    Institute of Scientific and Technical Information of China (English)

    芮亚然; 刘维国; 李冬玲; 张严

    2012-01-01

    Dopamine (DA) is the most abundant catecholaminergic neurotransmitter in the brain.It controls a variety of physiological functions of the central nervous system by Dopamine receptor, and Dopamine D2 receptor has been associated with a variety of neuropathological diseases, such as drug addiction, schizophrenia. Parkinson's disease. But so Tar. the structure of Dopamine D2 receptor is not available, which limited the design and development of relevenl drugs in this paper, the homology model of Dopamine D2 receptor was developed by using the Dopamine D3 receptor (JPBL) as template, which has (he highest sequence identity to D2 receptor. After Optimization and molecular dynamics simulation, the refined model structure was obtained. The final refined model was assessed by Profile-3D and Ramachamlran plot programs, then verified by docking with stepholidine(SPD). The results show that the Dopamine D2 model which we built is reasonable and reliable.%多巴胺是大脑中含量最丰富的儿茶酚胺类神经递质,主要通过多巴胺受体调控中枢神经系统的多种生理功能,其中多巴胺D2受体与药物成瘾、精神分裂症、帕金森病等多种疾病的发生相关.然而多巴胺D2受体的晶体结构至今尚未解析出来,给相关疾病的药物设计与开发带来困难.本文采用同源模建的方法,用目前与多巴胺D2受体同源性最高的多巴胺D3受体(3PBL)作为模板,构建多巴胺D2受体的三维结构.经过优化和分子动力学模拟,用Profile-3D和Ramachandran plot对模型进行评估,然后用多巴胺D2受体拮抗剂千金藤啶碱(stepholidine,SPD)进行对接验证,证明构建的多巴胺D2受体模型合理、可靠.

  14. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects.

    Science.gov (United States)

    Wager, Travis T; Chappie, Thomas; Horton, David; Chandrasekaran, Ramalakshmi Y; Samas, Brian; Dunn-Sims, Elizabeth R; Hsu, Cathleen; Nawreen, Nawshaba; Vanase-Frawley, Michelle A; O'Connor, Rebecca E; Schmidt, Christopher J; Dlugolenski, Keith; Stratman, Nancy C; Majchrzak, Mark J; Kormos, Bethany L; Nguyen, David P; Sawant-Basak, Aarti; Mead, Andy N

    2017-01-18

    Dopamine receptor antagonism is a compelling molecular target for the treatment of a range of psychiatric disorders, including substance use disorders. From our corporate compound file, we identified a structurally unique D3 receptor (D3R) antagonist scaffold, 1. Through a hybrid approach, we merged key pharmacophore elements from 1 and D3 agonist 2 to yield the novel D3R/D2R antagonist PF-4363467 (3). Compound 3 was designed to possess CNS drug-like properties as defined by its CNS MPO desirability score (≥4/6). In addition to good physicochemical properties, 3 exhibited low nanomolar affinity for the D3R (D3 Ki = 3.1 nM), good subtype selectivity over D2R (D2 Ki = 692 nM), and high selectivity for D3R versus other biogenic amine receptors. In vivo, 3 dose-dependently attenuated opioid self-administration and opioid drug-seeking behavior in a rat operant reinstatement model using animals trained to self-administer fentanyl. Further, traditional extrapyramidal symptoms (EPS), adverse side effects arising from D2R antagonism, were not observed despite high D2 receptor occupancy (RO) in rodents, suggesting that compound 3 has a unique in vivo profile. Collectively, our data support further investigation of dual D3R and D2R antagonists for the treatment of drug addiction.

  15. 30-year Dynamics of Terrestrial Vegetation Activity and the Relationship with Climatologies

    Science.gov (United States)

    de Jong, R.; Schaepman, M. E.; Furrer, R.; de Bruin, S.; Verburg, P. H.

    2013-12-01

    The climate governs the seasonal activity of terrestrial vegetation while humankind influences it. The relative role of these drivers in changing vegetation activity is crucial information for accurate modeling of vegetation and climate dynamics and for adaptation and mitigation strategies. Disentangling the two, however, is an ongoing scientific challenge, because of limited data availability, mainly regarding non-climatic drivers, and complex biosphere-atmosphere feedback mechanisms. Here, we contribute to this quest by modeling the spatial relationship between climatologies and changes in global vegetation activity (de Jong et al., 2013a). Vegetation activity is commonly quantified using remotely sensed vegetation indices (VI). Extensive reports on temporal trends over the past decades in time series of such indices can be found in literature, including the detection of shifts (de Jong et al., 2013b), which may be related to climate (e.g. Zhao & Running, 2010). However, little remains known about the exact processes underlying vegetation change at large spatial scales. Depending on eco-region, three climatologies potentially constrain plant growth (Churkina and Running, 1998). In the humid mid-latitudes, for example, temperature is the largest influencing factor; in (semi) arid regions it is the availability of water and in the tropics incident solar radiation. Based on this logic, we developed a mixed-effect model to relate changes in these climatologies to changes in vegetation activity and to quantify the spatial process underlying the other drivers, including human land use. Little over 50% of the spatial variation in vegetation change could be attributed to changes in climatologies; conspicuously, many of the global ';greening' trends and the ';browning' hotspots in Argentina and Australia. Browning hotspots in the non-climatic component were especially located in subequatorial Africa (e.g. parts of Zimbabwe and Tanzania), where human drivers may be

  16. Dynamic Adjustment of Climatological Ozone Boundary Conditions for Air-Quality Forecasts

    Directory of Open Access Journals (Sweden)

    P. A. Makar

    2010-06-01

    Full Text Available Ten different approaches for applying lateral and top climatological boundary conditions for ozone have been evaluated using the off-line regional air-quality model AURAMS. All ten approaches employ the same climatological ozone profiles, but differ in the manner in which they are applied, via the inclusion or exclusion of (i a dynamic adjustment of the climatological ozone profile in response to the model-predicted tropopause height, (ii a sponge zone for ozone on the model top, (iii upward extrapolation of the climatological ozone profile, and (iv different mass consistency corrections. The model performance for each approach was evaluated against North American surface ozone and ozonesonde observations from the BAQS-Met field study period in the summer of 2007. The original daily one-hour maximum surface ozone biases of about +15 ppbv were greatly reduced (halved in some simulations using alternative methodologies. However, comparisons to ozonesonde observations showed that the reduction in surface ozone bias sometimes came at the cost of significant positive biases in ozone concentrations in the free troposphere and upper troposphere. The best overall performance throughout the troposphere was achieved using a methodology that included dynamic tropopause height adjustment, no sponge zone at the model top, extrapolation of ozone when required above the limit of the climatology, and no mass consistency corrections (global mass conservation was still enforced. The simulation using this model version had a one-hour daily maximum surface ozone bias of +8.6 ppbv, with small reductions in model correlation, and the best comparison to ozonesonde profiles. This recommended and original methodologies were compared for two further case studies: a high-resolution simulation of the BAQS-Met measurement intensive, and a study of the downwind region of the Canadian Rockies. Significant improvements were noted for the high resolution simulations during the

  17. PREFACE: International Symposium on Dynamic Deformation and Fracture of Advanced Materials (D2FAM 2013)

    Science.gov (United States)

    Silberschmidt, Vadim V.

    2013-07-01

    ranged from traditional ones such as metals, alloys, polymers and composites to advanced and emerging materials, such as foams, cellular materials and metallic glasses, as well as bio-materials. Within the framework of the Symposium, a Special Session 'Parametric Resonance, Vibro-impact and Related Phenomena' was organised by partners of the FP7 IAPP project PARM-2: 'Vibro-impact machines based on parametric resonance: Concepts, mathematical modelling, experimental verification and implementation.' The Session focused on the topics, directly related to the project: excitation, stabilization, control and applications of parametric resonance (PR); multiple degrees of freedom of PR-excited systems; basic principles of PR-based macro and micro tools; design and technological aspects of PR-based machines; vibro-assisted machining; fatigue under high-amplitude vibro-impact conditions and corresponding optimal design; localisation near defects in dynamic response of elastic lattices and structures; dispersive waves and dynamic fracture in non-uniform lattice systems; thermally induced surface-breaking cracks, etc. This issue presents a selection of research papers presented at the International Symposium on Dynamic Deformation and Fracture of Advanced Materials D2FAM 2013. The Symposium Organisers would like to acknowledge its sponsors: Institute of Physics, International Centre of Vibro-Impact Systems and Marie Curie Action: Industry-Academia Partnerships and Pathways of the Seventh Framework Programme (FP7) of the European Commission (PARM-2 consortium). The PARM-2 consortium sponsored twenty scholarships for early-stage researchers to participate in this Symposium.

  18. Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation.

    Science.gov (United States)

    Soares-Cunha, Carina; Coimbra, Barbara; David-Pereira, Ana; Borges, Sonia; Pinto, Luisa; Costa, Patricio; Sousa, Nuno; Rodrigues, Ana J

    2016-06-23

    Striatal dopamine receptor D1-expressing neurons have been classically associated with positive reinforcement and reward, whereas D2 neurons are associated with negative reinforcement and aversion. Here we demonstrate that the pattern of activation of D1 and D2 neurons in the nucleus accumbens (NAc) predicts motivational drive, and that optogenetic activation of either neuronal population enhances motivation in mice. Using a different approach in rats, we further show that activating NAc D2 neurons increases cue-induced motivational drive in control animals and in a model that presents anhedonia and motivational deficits; conversely, optogenetic inhibition of D2 neurons decreases motivation. Our results suggest that the classic view of D1-D2 functional antagonism does not hold true for all dimensions of reward-related behaviours, and that D2 neurons may play a more prominent pro-motivation role than originally anticipated.

  19. Superconformal theories d=2,N=2 and w superalgebras; Theories superconformes d=2,N=2 et superalgebres w

    Energy Technology Data Exchange (ETDEWEB)

    Gourmelen, S

    1997-12-19

    Conformal invariance and supersymmetry are the two great fields of theoretical physics concerned with two dimensional conformal theories. These two dimensional conformal theories are here studied within the frame of supersymmetric N=2 extension in a no-metric formalism. The (2,0) and (2,2) Riemann super-surfaces (SSR) are characterized by Beltrami superfields. On such a SSR a superconformal field theory owns a local invariance linked to both diffeomorphisms and U-gauge symmetry. The study of these symmetries is carried out in the BRS formalism and applied to quantum anomaly determination. Sigma models are built on (2,0) and (2,2) SSR. Moreover the projective structures of SSR,N=2 are analysed by using a Schwartz connection which enables us to build super-differential covariant operators under superconformal transformations defined on SSR. These operators are categorized and their matrix analysis leads, owing to null curvature condition, to the study of W superalgebra. (author) 130 refs.

  20. Hybrid 3D-2D printing of bone scaffolds Hybrid 3D-2D printing methods for bone scaffolds fabrication.

    Science.gov (United States)

    Prinz, V Ya; Seleznev, Vladimir

    2016-12-13

    It is a well-known fact that bone scaffold topography on micro- and nanometer scale influences the cellular behavior. Nano-scale surface modification of scaffolds allows the modulation of biological activity for enhanced cell differentiation. To date, there has been only a limited success in printing scaffolds with micro- and nano-scale features exposed on the surface. To improve on the currently available imperfect technologies, in our paper we introduce new hybrid technologies based on a combination of 2D (nano imprint) and 3D printing methods. The first method is based on using light projection 3D printing and simultaneous 2D nanostructuring of each of the layers during the formation of the 3D structure. The second method is based on the sequential integration of preliminarily created 2D nanostructured films into a 3D printed structure. The capabilities of the developed hybrid technologies are demonstrated with the example of forming 3D bone scaffolds. The proposed technologies can be used to fabricate complex 3D micro- and nanostructured products for various fields. Copyright 2016 IOP Publishing Ltd.

  1. Deformable 3D-2D registration for CT and its application to low dose tomographic fluoroscopy

    Science.gov (United States)

    Flach, Barbara; Brehm, Marcus; Sawall, Stefan; Kachelrieß, Marc

    2014-12-01

    Many applications in medical imaging include image registration for matching of images from the same or different modalities. In the case of full data sampling, the respective reconstructed images are usually of such a good image quality that standard deformable volume-to-volume (3D-3D) registration approaches can be applied. But research in temporal-correlated image reconstruction and dose reductions increases the number of cases where rawdata are available from only few projection angles. Here, deteriorated image quality leads to non-acceptable deformable volume-to-volume registration results. Therefore a registration approach is required that is robust against a decreasing number of projections defining the target position. We propose a deformable volume-to-rawdata (3D-2D) registration method that aims at finding a displacement vector field maximizing the alignment of a CT volume and the acquired rawdata based on the sum of squared differences in rawdata domain. The registration is constrained by a regularization term in accordance with a fluid-based diffusion. Both cost function components, the rawdata fidelity and the regularization term, are optimized in an alternating manner. The matching criterion is optimized by a conjugate gradient descent for nonlinear functions, while the regularization is realized by convolution of the vector fields with Gaussian kernels. We validate the proposed method and compare it to the demons algorithm, a well-known 3D-3D registration method. The comparison is done for a range of 4-60 target projections using datasets from low dose tomographic fluoroscopy as an application example. The results show a high correlation to the ground truth target position without introducing artifacts even in the case of very few projections. In particular the matching in the rawdata domain is improved compared to the 3D-3D registration for the investigated range. The proposed volume-to-rawdata registration increases the robustness regarding sparse

  2. The SH2D2A gene and susceptibility to multiple sclerosis

    DEFF Research Database (Denmark)

    Lorentzen, A.R.; Smestad, C.; Lie, B.A.

    2008-01-01

    We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid...... that the SH2D2A gene may contribute to susceptibility to MS Udgivelsesdato: 2008/7/15...

  3. The Implementation of C-ID, R2D2 Model on Learning Reading Comprehension

    Science.gov (United States)

    Rayanto, Yudi Hari; Rusmawan, Putu Ngurah

    2016-01-01

    The purposes of this research are to find out, (1) whether C-ID, R2D2 model is effective to be implemented on learning Reading comprehension, (2) college students' activity during the implementation of C-ID, R2D2 model on learning Reading comprehension, and 3) college students' learning achievement during the implementation of C-ID, R2D2 model on…

  4. Automatic masking for robust 3D-2D image registration in image-guided spine surgery

    Science.gov (United States)

    Ketcha, M. D.; De Silva, T.; Uneri, A.; Kleinszig, G.; Vogt, S.; Wolinsky, J.-P.; Siewerdsen, J. H.

    2016-03-01

    During spinal neurosurgery, patient-specific information, planning, and annotation such as vertebral labels can be mapped from preoperative 3D CT to intraoperative 2D radiographs via image-based 3D-2D registration. Such registration has been shown to provide a potentially valuable means of decision support in target localization as well as quality assurance of the surgical product. However, robust registration can be challenged by mismatch in image content between the preoperative CT and intraoperative radiographs, arising, for example, from anatomical deformation or the presence of surgical tools within the radiograph. In this work, we develop and evaluate methods for automatically mitigating the effect of content mismatch by leveraging the surgical planning data to assign greater weight to anatomical regions known to be reliable for registration and vital to the surgical task while removing problematic regions that are highly deformable or often occluded by surgical tools. We investigated two approaches to assigning variable weight (i.e., "masking") to image content and/or the similarity metric: (1) masking the preoperative 3D CT ("volumetric masking"); and (2) masking within the 2D similarity metric calculation ("projection masking"). The accuracy of registration was evaluated in terms of projection distance error (PDE) in 61 cases selected from an IRB-approved clinical study. The best performing of the masking techniques was found to reduce the rate of gross failure (PDE > 20 mm) from 11.48% to 5.57% in this challenging retrospective data set. These approaches provided robustness to content mismatch and eliminated distinct failure modes of registration. Such improvement was gained without additional workflow and has motivated incorporation of the masking methods within a system under development for prospective clinical studies.

  5. Flap loop of GluD2 binds to Cbln1 and induces presynaptic differentiation

    OpenAIRE

    Kuroyanagi, Tomoaki; Hirano, Tomoo

    2010-01-01

    Glutamate receptor delta2 (GluD2) is selectively expressed on the postsynaptic spines at parallel-fiber (PF)-Purkinje neuron (PN) synapses. GluD2 knockout mice show a reduced number of PF-PN synapses, suggesting that GluD2 is involved in synapse formation. Recent studies revealed that GluD2 induces presynaptic differentiation in a manner dependent on its N-terminal domain (NTD) through binding of Cbln1 secreted from cerebellar granule neurons. However, the underlying mechanism of the specific...

  6. Chromosomal and Extrachromosomal Instability of the cyclin D2 Gene is Induced by Myc Overexpression

    Directory of Open Access Journals (Sweden)

    Sabine Mai

    1999-08-01

    Full Text Available We examined the expression of cyclins D1, D2, D3, and E in mouse B-lymphocytic tumors. Cyclin D2 mRNA was consistently elevated in plasmacytomas, which characteristically contain Myc-activating chromosome translocations and constitutive c-Myc mRNA and protein expression. We examined the nature of cyclin D2 overexpression in plasmacytomas and other tumors. Human and mouse tumor cell lines that exhibited c-Myc dysregulation displayed instability of the cyclin D2 gene, detected by Southern blot, fluorescent in situ hybridization (FISH, and in extrachromosomal preparations (Hirt extracts. Cyclin D2 instability was not seen in cells with low levels of c-Myc protein. To unequivocally demonstrate a role of c-Myc in the instability of the cyclin D2 gene, a Myc-estrogen receptor chimera was activated in two mouse cell lines. After 3 to 4 days of Myc-ERTm activation, instability at the cyclin D2 locus was seen in the form of extrachromosomal elements, determined by FISH of metaphase and interphase nuclei and of purified extrachromosomal elements. At the same time points, Northern and Western blot analyses detected increased cyclin D2 mRNA and protein levels. These data suggest that Myc-induced genomic instability may contribute to neoplasia by increasing the levels of a cell cycle—regulating protein, cyclin D2, via intrachromosomal amplification of its gene or generation of extrachromosomal copies.

  7. Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Hsu Anna

    2011-10-01

    Full Text Available Abstract Sulforaphane (SFN, an isothiocyanate derived from cruciferous vegetables, induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effects of SFN is the modulation of epigenetic marks, such as inhibition of histone deacetylase (HDAC enzymes. However, the effects of SFN on other common epigenetic marks such as DNA methylation are understudied. Promoter hyper-methylation of cyclin D2, a major regulator of cell cycle, is correlated with prostate cancer progression, and restoration of cyclin D2 expression exerts anti-proliferative effects on LnCap prostate cancer cells. Our study aimed to investigate the effects of SFN on DNA methylation status of cyclin D2 promoter, and how alteration in promoter methylation impacts cyclin D2 gene expression in LnCap cells. We found that SFN significantly decreased the expression of DNA methyltransferases (DNMTs, especially DNMT1 and DNMT3b. Furthermore, SFN significantly decreased methylation in cyclin D2 promoter regions containing c-Myc and multiple Sp1 binding sites. Reduced methlyation of cyclin D2 promoter corresponded to an increase in cyclin D2 transcript levels, suggesting that SFN may de-repress methylation-silenced cyclin D2 by impacting epigenetic pathways. Our results demonstrated the ability of SFN to epigenetically modulate cyclin D2 expression, and provide novel insights into the mechanisms by which SFN may regulate gene expression as a prostate cancer chemopreventive agent.

  8. Experimental Studies on the Formation of D2O and D2O2 by Implantation of Energetic D+ Ions into Oxygen Ices

    Science.gov (United States)

    Bennett, Chris J.; Ennis, Courtney P.; Kaiser, Ralf I.

    2014-02-01

    The formation of water (H2O) in the interstellar medium is intrinsically linked to grain-surface chemistry; thought to involve reactions between atomic (or molecular) hydrogen with atomic oxygen (O), molecular oxygen (O2), and ozone (O3). Laboratory precedent suggests that H2O is produced efficiently when O2 ices are exposed to H atoms (~100 K). This leads to the sequential generation of the hydroxyperoxyl radical (HO2), then hydrogen peroxide (H2O2), and finally H2O and a hydroxyl radical (OH); despite a barrier of ~2300 K for the last step. Recent detection of the four involved species toward ρ Oph A supports this general scenario; however, the precise formation mechanism remains undetermined. Here, solid O2 ice held at 12 K is exposed to a monoenergetic beam of 5 keV D+ ions. Products formed during the irradiation period are monitored through FTIR spectroscopy. O3 is observed through seven archetypal absorptions. Three additional bands found at 2583, 2707, and 1195 cm -1 correspond to matrix isolated DO2 (ν1) and D2O2 (ν1, ν5), and D2O (ν2), respectively. During subsequent warming, the O2 ice sublimates, revealing a broad band at 2472 cm-1 characteristic of amorphous D2O (ν1, ν3). Sublimating D2, D2O, D2O2, and O3 products were confirmed through their subsequent detection via quadrupole mass spectrometry. Reaction schemes based on both thermally accessible and suprathermally induced chemistries were developed to fit the observed temporal profiles are used to elucidate possible reaction pathways for the formation of D2-water. Several alternative schemes to the hydrogenation pathway (O2→HO2→H2O2→H2O) were identified; their astrophysical implications are briefly discussed.

  9. Dopamine D2 Receptors Regulate Collateral Inhibition between Striatal Medium Spiny Neurons

    Science.gov (United States)

    van der Goes, Marie-Sophie; Partridge, John G.; Vicini, Stefano

    2013-01-01

    The principle neurons of the striatum are GABAergic medium spiny neurons (MSNs), whose collateral synapses onto neighboring neurons play critical roles in striatal function. MSNs can be divided by dopamine receptor expression into D1-class and D2-class MSNs, and alterations in D2 MSNs are associated with various pathological states. Despite overwhelming evidence for D2 receptors (D2Rs) in maintaining proper striatal function, it remains unclear how MSN collaterals are specifically altered by D2R activation. Here, we report that chronic D2R stimulation regulates MSN collaterals in vitro by presynaptic and postsynaptic mechanisms. We used corticostriatal cultures from mice in which MSN subtypes were distinguished by fluorophore expression. Quinpirole, an agonist for D2/3 receptors, was used to chronically activate D2Rs. Quinpirole increased the rate and strength of collateral formation onto D2R-containing MSNs as measured by dual whole-cell patch-clamp recordings. Additionally, these neurons were more sensitive to low concentrations of GABA and exhibited an increase in gephyrin puncta density, suggesting increased postsynaptic GABAA receptors. Last, quinpirole treatment increased presynaptic GABA release sites, as shown by increased frequency of sIPSCs and mIPSCs, correlating with increased VGAT (vesicular GABA transporter) puncta. Combined with the observation that there were no detectable differences in sensitivity to specific GABAA receptor modulators, we provide evidence that D2R activation powerfully transforms MSN collaterals via coordinated presynaptic and postsynaptic alterations. As the D2 class of MSNs is highly implicated in Parkinson's disease and other neurological disorders, our findings may contribute to understanding and treating the changes that occur in these pathological states. PMID:23986243

  10. Hypoparathyroidism: Less Severe Hypocalcemia With Treatment With Vitamin D2 Compared With Calcitriol.

    Science.gov (United States)

    Streeten, Elizabeth A; Mohtasebi, Yasaman; Konig, Manige; Davidoff, Lisa; Ryan, Kathleen

    2017-05-01

    Options for chronic treatment of hypoparathyroidism include calcitriol, recombinant human parathyroid hormone, and high-dose vitamin D (D2). D2 is used in a minority of patients because of fear of prolonged hypercalcemia and renal toxicity. There is a paucity of recent data about D2 use in hypoparathyroidism. Compare renal function, hypercalcemia, and hypocalcemia in patients with hypoparathyroidism treated chronically with either D2 (D2 group) or calcitriol. A retrospective study of patients with hypoparathyroidism treated at the University of Maryland Hospital. Participants were identified by a billing record search with diagnosis confirmed by chart review. Thirty patients were identified; 16 were treated chronically with D2, 14 with calcitriol. Data were extracted from medical records. Serum creatinine and calcium, hospitalizations, and emergency department (ED) visits for hypercalcemia and hypocalcemia. D2 and calcitriol groups were similar in age (58.9 ± 16.7 vs 50.9 ± 22.6 years, P = 0.28), sex, and treatment duration (17.8 ± 14.2 vs 8.5 ± 4.4 years, P = 0.076). Hospitalization or ED visits for hypocalcemia occurred in none of the D2 group vs four of 14 in the calcitriol group (P = 0.03); three in the calcitriol group had multiple ED visits. There were no differences between D2 and calcitriol groups in hospitalizations or ED visits for hypercalcemia, serum creatinine or calcium, or kidney stones. We found less morbidity from hypocalcemia in hypoparathyroid patients treated chronically with D2 compared with calcitriol and found no difference in renal function or morbidity from hypercalcemia. Treatment with D2 should be considered in patients with hypoparathyroidism, particularly in those who experience recurrent hypocalcemia.

  11. D-2-hydroxyglutarate metabolism is linked to photorespiration in the shm1-1 mutant.

    Science.gov (United States)

    Kuhn, A; Engqvist, M K M; Jansen, E E W; Weber, A P M; Jakobs, C; Maurino, V G

    2013-07-01

    The Arabidopsis mutant shm1-1 is defective in mitochondrial serine hydroxymethyltransferase 1 activity and displays a lethal photorespiratory phenotype at ambient CO2 concentration but grows normally at high CO2 . After transferring high CO2 -grown shm1-1 plants to ambient CO2 , the younger leaves remain photosynthetically active while developed leaves display increased yellowing and decreased FV /FM values. Metabolite analysis of plants transferred from high CO2 to ambient air indicates a massive light-dependent (photorespiratory) accumulation of glycine, 2-oxoglutarate (2OG) and D-2-hydroxyglutarate (D-2HG). Amino acid markers of senescence accumulated in ambient air in wild-type and shm1-1 plants maintained in darkness and also build up in shm1-1 in the light. This, together with an enhanced transcription of the senescence marker SAG12 in shm1-1, suggests the initiation of senescence in shm1-1 under photorespiratory conditions. Mitochondrial D-2HG dehydrogenase (D-2HGDH) converts D-2HG into 2OG. In vitro studies indicate that 2OG exerts competitive inhibition on D-2HGDH with a Ki of 1.96 mm. 2OG is therefore a suitable candidate as inhibitor of the in vivo D-2HGDH activity, as 2OG is produced and accumulates in mitochondria. Inhibition of the D-2HGDH by 2OG is likely a mechanism by which D-2HG accumulates in shm1-1, however it cannot be ruled out that D-2HG may also accumulate due to an active senescence programme that is initiated in these plants after transfer to photorespiratory conditions. Thus, a novel interaction of the photorespiratory pathway with cellular processes involving D-2HG has been identified.

  12. GMMIP (v1.0) contribution to CMIP6: Global Monsoons Model Inter-comparison Project

    OpenAIRE

    Zhou, Tianjun; Turner, Andrew G.; Kinter, James L.; Qian, Yun; Chen, Xiaolong; Bo WU; Wang, Bin; Liu, Bo; Zou, Liwei; He, Bian

    2016-01-01

    The Global Monsoons Model Inter-comparison Project (GMMIP) has been endorsed by the panel of Coupled Model Inter-comparison Project (CMIP) as one of the participating model inter-comparison projects (MIPs) in the sixth phase of CMIP (CMIP6). The focus of GMMIP is on monsoon climatology, variability, prediction and projection, which is relevant to four of the “Grand Challenges” proposed by the World Climate Research Programme. At present, 21 international modeling groups are ...

  13. Effect of supplementation with vitamin D2-enhanced mushrooms on vitamin D status in healthy adults.

    Science.gov (United States)

    Stepien, Magdalena; O'Mahony, Louise; O'Sullivan, Aifric; Collier, John; Fraser, William D; Gibney, Michael J; Nugent, Anne P; Brennan, Lorraine

    2013-01-01

    Vitamin D deficiency is emerging worldwide and many studies now suggest its role in the development of several chronic diseases. Due to the low level of vitamin D naturally occurring in food there is a need for supplementation and use of vitamin D-enhanced products. The aim of the present study was to determine if daily consumption of vitamin D2-enhanced mushrooms increased vitamin D status in free-living healthy adults or affected markers of the metabolic syndrome. A total of ninety volunteers (aged 40-65 years) were randomly assigned to one of two 4-week studies: mushroom study (15 µg vitamin D2 or placebo mushroom powder) and capsule study (15 µg vitamin D3 or placebo capsules). Consumption of vitamin D2-enhanced mushrooms increased serum 25-hydroxyvitamin D2 (25(OH)D2) by 128 % from baseline (3·9 (sd 1·9) nmol/l; P D3 increased significantly in the vitamin D3 capsule group (a 55 % increase from a baseline of 44.0 (sd 17·1) nmol/l; P Vitamin D status (25(OH)D) was affected only in the vitamin D3 group. Plasminogen activator inhibitor-1 was lowered by vitamin D2 intake. Vitamin D2 from enhanced mushrooms was bioavailable and increased serum 25(OH)D2 concentration with no significant effect on 25(OH)D3 or total 25(OH)D.

  14. Vitamins D2 and D3 in new world primates: influence on calcium absorption.

    Science.gov (United States)

    Hunt, R D; Garcia, F G; Hegsted, D M; Kaplinsky, N

    1967-08-25

    In Cebus albifrons monkeys it was demonstrated that vitamin D(3) promotes the intestinal absorption of calcium-47 and that vitamin D(2) does not increase absorption above that seen in monkeys deficient in vitamin D. These data support previous observations that vitamin D(2) is not effective in preventing metabolic bone disease in this species.

  15. Translational Modeling in Schizophrenia : Predicting Human Dopamine D2 Receptor Occupancy

    NARCIS (Netherlands)

    Johnson, Martin; Kozielska, Magdalena; Pilla Reddy, Venkatesh; Vermeulen, An; Barton, Hugh A; Grimwood, Sarah; de Greef, Rik; Groothuis, Geny M M; Danhof, Meindert; Proost, Johannes H

    2015-01-01

    OBJECTIVES: To assess the ability of a previously developed hybrid physiology-based pharmacokinetic-pharmacodynamic (PBPKPD) model in rats to predict the dopamine D2 receptor occupancy (D2RO) in human striatum following administration of antipsychotic drugs. METHODS: A hybrid PBPKPD model, previousl

  16. Reducing Ventral Tegmental Dopamine D2 Receptor Expression Selectively Boosts Incentive Motivation

    NARCIS (Netherlands)

    De Jong, Johannes W.; Roelofs, Theresia J M; Mol, Frédérique M U; Hillen, Anne E J; Meijboom, Katharina E.; Luijendijk, Mieneke C M; Van Der Eerden, Harrie A M; Garner, Keith M.; Vanderschuren, Louk J M J; Adan, Roger A H

    2015-01-01

    Altered mesolimbic dopamine signaling has been widely implicated in addictive behavior. For the most part, this work has focused on dopamine within the striatum, but there is emerging evidence for a role of the auto-inhibitory, somatodendritic dopamine D2 receptor (D2R) in the ventral tegmental area

  17. Quantitative Imaging of D-2-Hydroxyglutarate in Selected Histological Tissue Areas by a Novel Bioluminescence Technique.

    Science.gov (United States)

    Voelxen, Nadine F; Walenta, Stefan; Proescholdt, Martin; Dettmer, Katja; Pusch, Stefan; Mueller-Klieser, Wolfgang

    2016-01-01

    Patients with malignant gliomas have a poor prognosis with average survival of less than 1 year. Whereas in other tumor entities the characteristics of tumor metabolism are successfully used for therapeutic approaches, such developments are very rare in brain tumors, notably in gliomas. One metabolic feature characteristic of gliomas, in particular diffuse astrocytomas and oligodendroglial tumors, is the variable content of D-2-hydroxyglutarate (D2HG), a metabolite that was discovered first in this tumor entity. D2HG is generated in large amounts due to various "gain-of-function" mutations in the isocitrate dehydrogenases IDH1 and IDH2. Meanwhile, D2HG has been detected in several other tumor entities, including intrahepatic bile-duct cancer, chondrosarcoma, acute myeloid leukemia, and angioimmunoblastic T-cell lymphoma. D2HG is barely detectable in healthy tissue (bioluminescence assay for determining D2HG in sections of snap-frozen tissue. The assay was verified independently by photometric tests and liquid chromatography/mass spectrometry. The novel technique allows the microscopically resolved determination of D2HG in a concentration range of 0-10 μmol/g tissue (wet weight). In combination with the already established bioluminescence imaging techniques for ATP, glucose, pyruvate, and lactate, the novel D2HG assay enables a comparative characterization of the metabolic profile of individual tumors in a further dimension.

  18. Stability of globular proteins in H2O and D2O

    NARCIS (Netherlands)

    Efimova, Y. M.; Haemers, S.; Wierczinski, B.; Norde, W.; van Well, A. A.

    2007-01-01

    In several experimental techniques D2O rather then H2O is often used as a solvent for proteins. Concerning the influence of the solvent on the stability of the proteins, contradicting results have been reported in literature. In this paper the influence of H2O-D2O solvent substitution on the stabili

  19. Neural Substrates of Dopamine D2 Receptor Modulated Executive Functions in the Monkey Prefrontal Cortex.

    Science.gov (United States)

    Puig, M Victoria; Miller, Earl K

    2015-09-01

    Dopamine D2 receptors (D2R) play a major role in cognition, mood and motor movements. Their blockade by antipsychotic drugs reduces hallucinatory and delusional behaviors in schizophrenia, but often fails to alleviate affective and cognitive dysfunctions. The prefrontal cortex (PFC) expresses D2R and is altered in schizophrenia. We investigated how D2R modulate behavior and PFC function in monkeys. Two monkeys learned new and performed highly familiar visuomotor associations, where each cue was associated with a saccade to a right or left target. We recorded neural spikes and local field potentials from multiple electrodes while injecting the D2R antagonist eticlopride in the lateral PFC. Blocking prefrontal D2R impaired associative learning and cognitive flexibility, reduced motivation, but left the performance of familiar associations intact. Eticlopride reduced saccade-direction selectivity of prefrontal neurons, leading to a decrease in neural information about the associations, and an increase in alpha oscillations. These results, together with our recent study using a D1R antagonist, suggest that D1R and D2R in the primate lateral PFC cooperate to modulate several executive functions. Our findings help to gain insight into why antipsychotic drugs, with strong antagonistic actions on D2R, fail to ameliorate cognitive and emotional deficits in schizophrenia.

  20. Stability of globular proteins in H2O and in D2O

    NARCIS (Netherlands)

    Efimova, Y.M.; Haemers, S.; Wierczinsky, B.; Norde, W.; Well, van A.A.

    2007-01-01

    In several experimental techniques D2O rather then H2O is often used as a solvent for proteins. Concerning the influence of the solvent on the stability of the proteins, contradicting results have been reported in literature. In this paper the influence of H2O-D2O solvent substitution on the

  1. Stability of globular proteins in H2O and D2O

    NARCIS (Netherlands)

    Efimova, Y. M.; Haemers, S.; Wierczinski, B.; Norde, W.; van Well, A. A.

    2007-01-01

    In several experimental techniques D2O rather then H2O is often used as a solvent for proteins. Concerning the influence of the solvent on the stability of the proteins, contradicting results have been reported in literature. In this paper the influence of H2O-D2O solvent substitution on the

  2. Estimating Dopamine D-2 Receptor Occupancy for Doses of 8 Antipsychotics : A Meta-Analysis

    NARCIS (Netherlands)

    Lako, Irene M.; van den Heuvel, Edwin R.; Knegtering, Henrikus; Bruggeman, Richard; Taxis, Katja

    2013-01-01

    Rationale: Dose equivalents based on dopamine D-2 receptor occupancy can be used to compare antipsychotics on D-2 receptor-mediated (adverse) effects such as extrapyramidal symptoms and altered emotional experiences. Previous meta-analyses modeling the dose-occupancy relationship hardly addressed po

  3. Striatal dopamine D2/3 receptor availability in treatment resistant depression.

    Directory of Open Access Journals (Sweden)

    Bart P de Kwaasteniet

    Full Text Available Several studies demonstrated improvement of depressive symptoms in treatment resistant depression (TRD after administering dopamine agonists which suggest abnormal dopaminergic neurotransmission in TRD. However, the role of dopaminergic signaling through measurement of striatal dopamine D(2/3 receptor (D2/3R binding has not been investigated in TRD subjects. We used [(123I]IBZM single photon emission computed tomography (SPECT to investigate striatal D2/3R binding in TRD. We included 6 severe TRD patients, 11 severe TRD patients on antipsychotics (TRD AP group and 15 matched healthy controls. Results showed no significant difference (p = 0.75 in striatal D2/3R availability was found between TRD patients and healthy controls. In the TRD AP group D2/3R availability was significantly decreased (reflecting occupancy of D2/3Rs by antipsychotics relative to TRD patients and healthy controls (p<0.001 but there were no differences in clinical symptoms between TRD AP and TRD patients. This preliminary study therefore does not provide evidence for large differences in D2/3 availability in severe TRD patients and suggests this TRD subgroup is not characterized by altered dopaminergic transmission. Atypical antipsychotics appear to have no clinical benefit in severe TRD patients who remain depressed, despite their strong occupancy of D2/3Rs.

  4. TRMM precipitation analysis of extreme storms in South America: Bias and climatological contribution

    Science.gov (United States)

    Rasmussen, K. L.; Houze, R.; Zuluaga, M. D.; Choi, S. L.; Chaplin, M.

    2013-12-01

    The TRMM (Tropical Rainfall Measuring Mission) satellite was designed both to measure spatial and temporal variation of tropical rainfall around the globe and to understand the factors controlling the precipitation. TRMM observations have led to the realization that storms just east of the Andes in southeastern South America are among the most intense deep convection in the world. For a complete perspective of the impact of intense precipitation systems on the hydrologic cycle in South America, it is necessary to assess the contribution from various forms of extreme storms to the climatological rainfall. However, recent studies have suggested that the TRMM Precipitation Radar (PR) algorithm significantly underestimates surface rainfall in deep convection over land. Prior to investigating the climatological behavior, this research first investigates the range of the rain bias in storms containing four different types of extreme radar echoes: deep convective cores, deep and wide convective cores, wide convective cores, and broad stratiform regions over South America. The TRMM PR algorithm exhibits bias in all four extreme echo types considered here when the algorithm rates are compared to a range of conventional Z-R relations. Storms with deep convective cores, defined as high reflectivity echo volumes that extend above 10 km in altitude, show the greatest underestimation, and the bias is unrelated to their echo top height. The bias in wide convective cores, defined as high reflectivity echo volumes that extend horizontally over 1,000 km2, relates to the echo top, indicating that storms with significant mixed phase and ice hydrometeors are similarly affected by assumptions in the TRMM PR algorithm. The subtropical region tends to have more intense precipitating systems than the tropics, but the relationship between the TRMM PR rain bias and storm type is the same regardless of the climatological regime. The most extreme storms are typically not collocated with

  5. Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility.

    Science.gov (United States)

    Chandra, Ramesh; Francis, T Chase; Nam, Hyungwoo; Riggs, Lace M; Engeln, Michel; Rudzinskas, Sarah; Konkalmatt, Prasad; Russo, Scott J; Turecki, Gustavo; Iniguez, Sergio D; Lobo, Mary Kay

    2017-07-05

    Previous research demonstrates that Slc6a15, a neutral amino acid transporter, is associated with depression susceptibility. However, no study examined Slc6a15 in the ventral striatum [nucleus accumbens (NAc)] in depression. Given our previous characterization of Slc6a15 as a striatal dopamine receptor 2 (D2)-neuron-enriched gene, we examined the role of Slc6a15 in NAc D2-neurons in mediating susceptibility to stress in male mice. First, we showed that Slc6a15 mRNA was reduced in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces behavioral and molecular adaptations that resemble clinical depression. Consistent with our preclinical data, we observed Slc6a15 mRNA reduction in NAc of individuals with major depressive disorder (MDD). The Slc6a15 reduction in NAc occurred selectively in D2-neurons. Next, we used Cre-inducible viruses combined with D2-Cre mice to reduce or overexpress Slc6a15 in NAc D2-neurons. Slc6a15 reduction in D2-neurons caused enhanced susceptibility to a subthreshold social defeat stress (SSDS) as observed by reduced social interaction, while a reduction in social interaction following CSDS was not observed when Slc6a15 expression in D2-neurons was restored. Finally, since both D2-medium spiny neurons (MSNs) and D2-expressing choline acetyltransferase (ChAT) interneurons express Slc6a15, we examined Slc6a15 protein in these interneurons after CSDS. Slc6a15 protein was unaltered in ChAT interneurons. Consistent with this, reducing Slc5a15 selectively in NAc D2-MSNs, using A2A-Cre mice that express Cre selectively in D2-MSNs, caused enhanced susceptibility to SSDS. Collectively, our data demonstrate that reduced Slc6a15 in NAc occurs in MDD individuals and that Slc6a15 reduction in NAc D2-neurons underlies stress susceptibility.SIGNIFICANCE STATEMENT Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. The

  6. A Satellite-Derived Climatological Analysis of Urban Heat Island over Shanghai during 2000–2013

    Directory of Open Access Journals (Sweden)

    Weijiao Huang

    2017-06-01

    Full Text Available The urban heat island is generally conducted based on ground observations of air temperature and remotely sensing of land surface temperature (LST. Satellite remotely sensed LST has the advantages of global coverage and consistent periodicity, which overcomes the weakness of ground observations related to sparse distributions and costs. For human related studies and urban climatology, canopy layer urban heat island (CUHI based on air temperatures is extremely important. This study has employed remote sensing methodology to produce monthly CUHI climatology maps during the period 2000–2013, revealing the spatiotemporal characteristics of daytime and nighttime CUHI during this period of rapid urbanization in Shanghai. Using stepwise linear regression, daytime and nighttime air temperatures at the four overpass times of Terra/Aqua were estimated based on time series of Terra/Aqua-MODIS LST and other auxiliary variables including enhanced vegetation index, normalized difference water index, solar zenith angle and distance to coast. The validation results indicate that the models produced an accuracy of 1.6–2.6 °C RMSE for the four overpass times of Terra/Aqua. The models based on Terra LST showed higher accuracy than those based on Aqua LST, and nighttime air temperature estimation had higher accuracy than daytime. The seasonal analysis shows daytime CUHI is strongest in summer and weakest in winter, while nighttime CUHI is weakest in summer and strongest in autumn. The annual mean daytime CUHI during 2000–2013 is 1.0 and 2.2 °C for Terra and Aqua overpass, respectively. The annual mean nighttime CUHI is about 1.0 °C for both Terra and Aqua overpass. The resultant CUHI climatology maps provide a spatiotemporal quantification of CUHI with emphasis on temperature gradients. This study has provided information of relevance to urban planners and environmental managers for assessing and monitoring urban thermal environments which are constantly

  7. Technical Note: Ozonesonde climatology between 1995 and 2011: description, evaluation and applications

    Directory of Open Access Journals (Sweden)

    S. Tilmes

    2012-08-01

    Full Text Available An ozone climatology based on ozonesonde measurements taken over the last 17 yr has been constructed for model evaluation and comparisons to other observations. Vertical ozone profiles for 42 stations around the globe have been compiled for the period 1995–2011, in pressure and tropopause-referenced altitudes. For each profile, the mean, standard deviation, median, the half-width are provided, as well as information about interannual variability. Regional aggregates are formed in combining stations with similar ozone characteristics. The Hellinger distance is introduced as a new diagnostic to identify stations that describe similar shapes of ozone probability distribution functions (PDFs. In this way, 12 regions were selected covering at least 2 stations and the variability among those stations is discussed. Significant variability with longitude of ozone distributions in the troposphere and lower stratosphere in the northern mid- and high latitudes is found. The representativeness of regional aggregates is discussed for high northern latitudes, Western Europe, Eastern US, and Japan, using independent observations from surface stations and MOZAIC aircraft data. Good agreement exists between ozonesondes and aircraft observations in the mid-troposphere and between ozonesondes and surface observations for Western Europe. For Eastern US and high northern latitudes, surface ozone values from ozonesondes are biased 10 ppb high compared to independent measurements. An application of the climatology is presented using the NCAR CAM-Chem model. The climatology allows evaluation of the model performance regarding ozone averages, seasonality, interannual variability, and the shape of ozone distributions. The new assessment of the key features of ozone distributions gives deeper insights into the performance of models.

  8. Comparison of five gridded precipitation products at climatological scales over West Africa

    Science.gov (United States)

    Akinsanola, A. A.; Ogunjobi, K. O.; Ajayi, V. O.; Adefisan, E. A.; Omotosho, J. A.; Sanogo, S.

    2016-12-01

    The paper aimed at assessing the capabilities and limitations of five different precipitation products to describe rainfall over West Africa. Five gridded precipitation datasets of the Tropical Rainfall Measurement Mission (TRMM) Multi-Platform Analysis (TMPA 3B43v7); University of Delaware (UDEL version 3.01); Climatic Research Unit (CRU version 3.1); Global Precipitation Climatology Centre (GPCC version 7) and African Rainfall Climatology (ARC version 2) were compared and validated with reference ground observation data from 81 stations spanning a 19-year period, from January 1990 to December 2008. Spatial investigation of the precipitation datasets was performed, and their capability to replicate the inter-annual and intra-seasonal variability was also assessed. The ability of the products to capture the El Nino and La Nina events were also assessed. Results show that all the five datasets depicted similar spatial distribution of mean rainfall climatology, although differences exist in the total rainfall amount for each precipitation dataset. Further analysis shows that the three distinct phases of the mean annual cycle of the West Africa Monsoon precipitation were well captured by the datasets. However, CRU, GPCC and UDEL failed to capture the little dry season in the month of August while UDEL and GPCC underestimated rainfall amount in the Sahel region. Results of the inter-annual precipitation anomalies shows that ARC2 fail to capture about 46% of the observed variability while the other four datasets exhibits a greater performance (r > 0.9). All the precipitation dataset except ARC2 were consistent with the ground observation in capturing the dry and wet conditions associated with El Nino and La Nina events, respectively. ARC2 tends to overestimate the El Nino event and failed to capture the La Nina event in all the years considered. In general GPCC, CRU and TRMM were found to be the most outstanding datasets and can, therefore, be used for precipitation

  9. A global ocean climatology of preindustrial and modern ocean δ13C

    Science.gov (United States)

    Eide, Marie; Olsen, Are; Ninnemann, Ulysses S.; Johannessen, Truls

    2017-03-01

    We present a global ocean climatology of dissolved inorganic carbon δ13C (‰) corrected for the 13C-Suess effect, preindustrial δ13C. This was constructed by first using Olsen and Ninnemann's (2010) back-calculation method on data from 25 World Ocean Circulation Experiment cruises to reconstruct the preindustrial δ13C on sections spanning all major oceans. Next, we developed five multilinear regression equations, one for each major ocean basin, which were applied on the World Ocean Atlas data to construct the climatology. This reveals the natural δ13C distribution in the global ocean. Compared to the modern distribution, the preindustrial δ13C spans a larger range of values. The maxima, of up to 1.8‰, occurs in the subtropical gyres of all basins, in the upper and intermediate waters of the North Atlantic, as well as in mode waters with a Southern Ocean origin. Particularly strong gradients occur at intermediate depths, revealing a strong potential for using δ13C as a tracer for changes in water mass geometry at these levels. Further, we identify a much tighter relationship between δ13C and apparent oxygen utilization (AOU) than between δ13C and phosphate. This arises because, in contrast to phosphate, AOU and δ13C are both partly reset when waters are ventilated in the Southern Ocean and underscore that δ13C is a highly robust proxy for past changes in ocean oxygen content and ocean ventilation. Our global preindustrial δ13C climatology is openly accessible and can be used, for example, for improved model evaluation and interpretation of sediment δ13C records.

  10. Climatology and trends of summer high temperature days in India during 1969–2013

    Indian Academy of Sciences (India)

    A K Jaswal; P C S Rao; Virendra Singh

    2015-02-01

    Based on the daily maximum air temperature data from 176 stations in India from 1969 to 2013, the climatological distribution of the number of days with high temperature (HT) defined as days with maximum temperature higher than 37°C during summer season (March–June) are studied. With a focus on the regional variability and long-term trends, the impacts of HT days are examined by dividing the country into six geographical regions (North, West, North-central, East, South-central and South). Although the long-term (1969–2013) climatological numbers of HT days display well-defined spatial patterns, there is clear change in climatological mean and coefficient of variation of HT days in a recent period (1991–2013). The long period trends indicate increase in summer HT days by 3%, 5%, and 18% in north, west, and south regions, respectively and decrease by 4% and 9% in north-central and east regions respectively. However, spatial variations in HT days exist across different regions in the country. The data analysis shows that 2010 was the warmest summer year and 2013 was the coolest summer year in India. Comparison of spatial distributions of trends in HT days for 1969–1990 and 1991–2013 periods reveal that there is an abrupt increase in the number of HT days over north, west and north-central regions of India probably from mid 1990s. A steep increase in summer HT days in highly populated cities of Mumbai, New Delhi, Chennai, Jaipur, and Visakhapatnam is noticed during the recent period of 1991–2013. The summer HT days over southern India indicate significant positive correlation with Nino 3.4 index for three months’ running mean (December–January–February, January–March, February–April, March–May and April–June).

  11. The Martian Dust Chronicle: Eight Years of Reconstructed Climatology from Spacecraft Observations

    Science.gov (United States)

    Montabone, Luca; Forget, François; Millour, Ehouarn; Wilson, R. John; Lewis, Stephen R.; Kass, David; Kleinboehl, Armin; Lemmon, Mark T.; Smith, Michael D.; Wolff, Mike J.

    2014-05-01

    We have reconstructed the climatology of airborne dust from Martian years (MY) 24 to 31 using multiple datasets of retrieved or estimated column optical depth. The datasets are based on observations of the Martian atmosphere from March 1999 to July 2013 by different orbiting instruments: the Thermal Emission Spectrometer (TES) on board Mars Global Surveyor, the Thermal Emission Imaging System (THEMIS) on board Mars Odyssey, and the Mars Climate Sounder (MCS) on board Mars Reconnaissance Orbiter (MRO). The procedure we have adopted consists in gridding the available retrievals of column dust optical depth (CDOD) from TES and THEMIS nadir observations, as well as the estimates of this quantity from MCS limb observations. Our gridding method calculates weighted averages on a regular but likely incomplete spatial grid, using an iterative procedure with weights in space, time, and retrieval uncertainty. The derived product consists of daily synoptic gridded maps of CDOD at a resolution of 6 degree longitude x 3 degree latitude for MY 24-26, and 6 degree longitude x 5 degree latitude for MY 27-31. We have statistically analyzed the gridded maps to present an overview of the dust climatology on Mars over eight years, specifically in relation to its intraseasonal and interannual variability. Finally, we have produced complete daily maps of CDOD by spatially interpolating the available incomplete gridded maps using a kriging method. These complete maps are used as dust scenarios in the Mars Climate Database (MCD) version 5, and should be useful for many other applications. The maps for the eight available Martian years are publicly available and distributed with open access, under Creative Commons Attribution-ShareAlike 3.0 Unported License. The current version and future updates can be downloaded from the MCD website at the Laboratoire de Meteorologie Dynamique: http://www-mars.lmd.jussieu.fr/mars/dust_climatology/

  12. Technical Note: A trace gas climatology derived from the Atmospheric Chemistry Experiment Fourier Transform Spectrometer dataset

    Directory of Open Access Journals (Sweden)

    A. Jones

    2011-11-01

    Full Text Available The Atmospheric Chemistry Experiment-Fourier Transform Spectrometer (ACE-FTS aboard the Canadian satellite SCISAT (launched in August 2003 was designed to investigate the composition of the upper troposphere, stratosphere, and mesosphere. ACE-FTS utilizes solar occultation to measure temperature and pressure as well as vertical profiles of over thirty chemical species including O3, H2O, CH4, N2O, CO, NO, NO2, N2O5, HNO3, HCl, ClONO2, CCl3F, CCl2F2, and HF. Global coverage for each species is obtained approximately over a three month period and measurements are made with a vertical resolution of typically 3–4 km. A quality-controlled climatology has been created for each of these 14 baseline species, where individual profiles are averaged over the period of February 2004 to February 2009. Measurements used are from the ACE-FTS version 2.2 data set including updates for O3 and N2O5. The climatological fields are provided on a monthly and three-monthly basis (DJF, MAM, JJA, SON at 5 degree latitude and equivalent latitude spacing and on 28 pressure surfaces (26 of which are defined by the Stratospheric Processes And their Role in Climate (SPARC Chemistry Climate Model validation activity. The ACE-FTS climatological dataset is available through the ACE website.

  13. Climatology and trends of summer high temperature days in India during 1969-2013

    Science.gov (United States)

    Jaswal, A. K.; Rao, P. C. S.; Singh, Virendra

    2015-02-01

    Based on the daily maximum air temperature data from 176 stations in India from 1969 to 2013, the climatological distribution of the number of days with high temperature (HT) defined as days with maximum temperature higher than 37°C during summer season (March-June) are studied. With a focus on the regional variability and long-term trends, the impacts of HT days are examined by dividing the country into six geographical regions (North, West, North-central, East, South-central and South). Although the long-term (1969-2013) climatological numbers of HT days display well-defined spatial patterns, there is clear change in climatological mean and coefficient of variation of HT days in a recent period (1991-2013). The long period trends indicate increase in summer HT days by 3%, 5%, and 18% in north, west, and south regions, respectively and decrease by 4% and 9% in north-central and east regions respectively. However, spatial variations in HT days exist across different regions in the country. The data analysis shows that 2010 was the warmest summer year and 2013 was the coolest summer year in India. Comparison of spatial distributions of trends in HT days for 1969-1990 and 1991-2013 periods reveal that there is an abrupt increase in the number of HT days over north, west and north-central regions of India probably from mid 1990s. A steep increase in summer HT days in highly populated cities of Mumbai, New Delhi, Chennai, Jaipur, and Visakhapatnam is noticed during the recent period of 1991-2013. The summer HT days over southern India indicate significant positive correlation with Nino 3.4 index for three months' running mean (December-January-February, January-March, February-April, March-May and April-June).

  14. Building a flood climatology and rethinking flood risk at continental scales

    Science.gov (United States)

    Andreadis, Konstantinos; Schumann, Guy; Stampoulis, Dimitrios; Smith, Andrew; Neal, Jeffrey; Bates, Paul; Sampson, Christopher; Brakenridge, Robert; Kettner, Albert

    2016-04-01

    Floods are one of the costliest natural disasters and the ability to understand their characteristics and their interactions with population, land cover and climate changes is of paramount importance. In order to accurately reproduce flood characteristics such as water inundation and heights both in the river channels and floodplains, hydrodynamic models are required. Most of these models operate at very high resolutions and are computationally very expensive, making their application over large areas very difficult. However, a need exists for such models to be applied at regional to global scales so that the effects of climate change with regards to flood risk can be examined. We use the a modeling framework that includes the VIC hydrologic and the LISFLOOD-FP hydrodynamic model to simulate a 40-year history of flood characteristics at the continental scale, particularly Australia. In order to extend the simulated flood climatology to 50-100 years in a consistent manner, reanalysis datasets have to be used as meteorological forcings to the models. The objective of this study is the evaluation of multiple atmospheric reanalysis datasets (ERA, NCEP, MERRA, JRA) as inputs to the VIC/LISFLOOD-FP model. Comparisons of the simulated flood characteristics are made with both satellite observations of inundation and a benchmark simulation of LISFLOOD-FP being forced by observed flows. The implications of having a climatology of flood characteristics are discussed, and in particular We found the magnitude and timing of floodplain water storage to significantly differ from streamflow in terms of their distribution. Furthermore, floodplain volume gave a much sharper discrimination of high hazard and low hazard periods than discharge, and using the latter can lead to significant overestimation. These results demonstrate that global streamflow statistics or precipitation should not be used to infer flood hazard and risk, but instead a flood inundation climatology is necessary.

  15. Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels

    DEFF Research Database (Denmark)

    Ljungstrom, Trine; Grunnet, Morten; Jensen, Bo Skaaning

    2003-01-01

    Activation of KCNQ potassium channels by stimulation of co-expressed dopamine D(2) receptors was studied electrophysiologically in Xenopus laevis oocytes and in mammalian cells. To address the specificity of the interaction between D(2)-like receptors and KCNQ channels, combinations of KCNQ1...... activation of the KCNQ channels was confirmed by co-expression of other neuronal K(+) channels (BK, K(V)1.1, and K(V)4.3) with the D(2L) receptor in Xenopus oocytes. None of these K(+) channels responded to stimulation of the D(2L) receptor. In the mammalian brain, dopamine D(2) receptors and KCNQ channels...... co-localise postsynaptically in several brain regions, so modulation of neuronal excitability by dopamine release could in part be mediated via an effect on KCNQ channels....

  16. The Dopamine D2 Receptor Gene in Lamprey, Its Expression in the Striatum and Cellular Effects of D2 Receptor Activation

    Science.gov (United States)

    Robertson, Brita; Huerta-Ocampo, Icnelia; Ericsson, Jesper; Stephenson-Jones, Marcus; Pérez-Fernández, Juan; Bolam, J. Paul; Diaz-Heijtz, Rochellys; Grillner, Sten

    2012-01-01

    All basal ganglia subnuclei have recently been identified in lampreys, the phylogenetically oldest group of vertebrates. Furthermore, the interconnectivity of these nuclei is similar to mammals and tyrosine hydroxylase-positive (dopaminergic) fibers have been detected within the input layer, the striatum. Striatal processing is critically dependent on the interplay with the dopamine system, and we explore here whether D2 receptors are expressed in the lamprey striatum and their potential role. We have identified a cDNA encoding the dopamine D2 receptor from the lamprey brain and the deduced protein sequence showed close phylogenetic relationship with other vertebrate D2 receptors, and an almost 100% identity within the transmembrane domains containing the amino acids essential for dopamine binding. There was a strong and distinct expression of D2 receptor mRNA in a subpopulation of striatal neurons, and in the same region tyrosine hydroxylase-immunoreactive synaptic terminals were identified at the ultrastructural level. The synaptic incidence of tyrosine hydroxylase-immunoreactive boutons was highest in a region ventrolateral to the compact layer of striatal neurons, a region where most striatal dendrites arborise. Application of a D2 receptor agonist modulates striatal neurons by causing a reduced spike discharge and a diminished post-inhibitory rebound. We conclude that the D2 receptor gene had already evolved in the earliest group of vertebrates, cyclostomes, when they diverged from the main vertebrate line of evolution (560 mya), and that it is expressed in striatum where it exerts similar cellular effects to that in other vertebrates. These results together with our previous published data (Stephenson-Jones et al. 2011, 2012) further emphasize the high degree of conservation of the basal ganglia, also with regard to the indirect loop, and its role as a basic mechanism for action selection in all vertebrates. PMID:22563388

  17. Chemical Composition and Dynamics of the Upper Troposphere and the Lower Stratosphere: Overview of the Project

    Science.gov (United States)

    Sofieva, V. F.; Liu, C.; Huang, F.; Kyrola, E.; Liu, Y.; Ialongo, I.; Hakkarainen, J.; Zhang, Y.

    2016-08-01

    The DRAGON-3 cooperation study on the upper troposphere and the lower stratosphere (UTLS) is based on new satellite data and modern atmospheric models. The objectives of the project are: (i) assessment of satellite data on chemical composition in UTLS, (ii) dynamical and chemical structures of the UTLS and its variability, (iii) multi-scale variability of stratospheric ozone, (iv) climatology of the stratospheric aerosol layer and its variability, and (v) updated ozone climatology and its relation to tropopause/multiple tropopauses.In this paper, we present the main results of the project.

  18. Japan/East Sea (JES) circulation and thermohaline structure, Part 1, Climatology

    OpenAIRE

    Lan, Jian; Fan, Chenwu; Chu, Peter C.

    2001-01-01

    Journal of Physical Oceanography, American Meteorological Society, 31 In this study, the U.S. Navy’s Generalized Digital Environmental Model (GDEM) climatological temperature and salinity data on a 0.58 3 0.58 grid is used to investigate the seasonal variabilities of the Japan/East Sea (JES) thermohaline structure and circulations. The GDEM for the JES was built up on historical (1930–97) 136 509 temperature and 52 572 salinity profiles. A three-dimensional estimate of the absolute...

  19. A global climatology of stratospheric OClO derived from GOMOS measurement

    Directory of Open Access Journals (Sweden)

    C. Tétard

    2013-04-01

    Full Text Available The Global Ozone Monitoring by Occultation of Stars (GOMOS instrument on board the European platform ENVISAT was dedicated to the study of the atmosphere of the Earth using the stellar occultation technique. The spectral range of the GOMOS spectrometer extends from the UV to the near infrared, allowing for the retrieval of species such as O3, NO2, NO3, H2O, O2, air density, aerosol extinction and OClO. Nevertheless, OClO can not be retrieved using a single GOMOS measurement because of the weak signal-to-noise ratio and the small optical thickness associated with this molecule. We present here the method used to detect this molecule by using several GOMOS measurements. It is based on a two-step approach. First, several co-located measurements are combined in a statistical way to build an averaged measurement with a higher signal-to-noise ratio. Then, a Differential Optical Absorption Spectroscopy (DOAS method is applied to retrieve OClO slant column densities. The statistics of the sets of GOMOS measurements used to build the averaged measurement and the spectral window selection are analyzed. The obtained retrievals are compared to results from two balloon-borne instruments. It appears that the inter-comparisons of OClO are generally satisfying. Then, two nighttime climatologies of OClO slant column densities based on GOMOS averaged measurements are presented. The first depicts annual global pictures of OClO from 2003 to 2011. From this climatology, the presence of an OClO layer in the equatorial region at about 35 km is confirmed and strong concentrations of OClO in both polar regions are observed, a sign of chlorine activation. The second climatology is a monthly time series. It clearly shows the chlorine activation of the lower stratosphere during winter. Moreover the equatorial OClO layer is observed during all the years without any significant variations. Finally, the anti-correlation between OClO and NO2 is highlighted. This very promising

  20. CIE D2 and Developments of Photometry Radiometry%CIE D2和光辐射测量动态

    Institute of Scientific and Technical Information of China (English)

    潘建根

    2005-01-01

    本文简单介绍国际照明委员会(CIE)第二分部(D2)的主要工作范围,介绍CIE D2目前已成立的技术委员会(TC),已出版的标准和技术文件等出版物.同时,本文还介绍在光和辐射测量领域内国际较为关注的热点问题和最新发展动态.

  1. Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280).

    Science.gov (United States)

    Li, M; Bermak, J C; Wang, Z W; Zhou, Q Y

    2000-03-01

    Proteins that bind to G protein-coupled receptors have recently been identified as regulators of receptor anchoring and signaling. In this study, actin-binding protein 280 (ABP-280), a widely expressed cytoskeleton-associated protein that plays an important role in regulating cell morphology and motility, was found to associate with the third cytoplasmic loop of dopamine D(2) receptors. The specificity of this interaction was originally identified in a yeast two-hybrid screen and confirmed by protein binding. The functional significance of the D(2) receptor-ABP-280 association was evaluated in human melanoma cells lacking ABP-280. D(2) receptor agonists were less potent in inhibiting forskolin-stimulated cAMP production in these cells. Maximal inhibitory responses of D(2) receptor activation were also reduced. Further yeast two-hybrid experiments showed that ABP-280 association is critically dependent on the carboxyl domain of the D(2) receptor third cytoplasmic loop, where there is a potential serine phosphorylation site (S358). Serine 358 was replaced with aspartic acid to mimic the effects of receptor phosphorylation. This mutant (D(2)S358D) displayed compromised binding to ABP-280 and coupling to adenylate cyclase. PKC activation also generated D(2) receptor signaling attenuation, but only in ABP-containing cells, suggesting a PKC regulatory role in D(2)-ABP association. A mechanism for these results may be derived from a role of ABP-280 in the clustering of D(2) receptors, as determined by immunocytochemical analysis in ABP-deficient and replete cells. Our results suggest a new molecular mechanism of modulating D(2) receptor signaling by cytoskeletal protein interaction.

  2. The Triple Functions of D2 Silencing in Treatment of Periapical Disease.

    Science.gov (United States)

    Pan, Jie; Wang, Jue; Hao, Liang; Zhu, Guochun; Nguyen, Diep N; Li, Qian; Liu, Yuehua; Zhao, Zhihe; Li, Yi-Ping; Chen, Wei

    2017-02-01

    Dental caries is the most widespread chronic infectious disease. Inflammation in pulp tissues caused by dental caries will lead to periapical granulomas, bone erosion, loss of the tooth, and severe pain. Despite numerous efforts in recent studies to develop effective treatments for dental caries, the need for a potent therapy is still urgent. In this study, we applied a gene-based therapy approach by administering recombinant adeno-associated virus (AAV)-mediated Atp6v0d2 (d2) RNA interference knockdown of d2 gene expression to prevent periapical bone loss and suppress periapical inflammation simultaneously. The results showed that d2 depletion is simultaneously capable of reducing bone resorption with 75% protection through reducing osteoclasts, enhancing bone formation by increasing osterix expression, and inhibiting inflammation by decreasing T-cell infiltration. Notably, AAV-mediated gene therapy of d2 knockdown significantly reduced proinflammatory cytokine expression, including tumor necrosis factor α, interferon-γ, interleukin-1α, and interleukin 6 levels in periapical diseases caused by bacterial infection. Quantitative real-time polymerase chain reaction revealed that d2 knockdown reduced osteoclast-specific functional genes (ie, Acp5 and Ctsk) and increased osteoblast marker genes (ie, Osx and Opg) in periapical tissues. Collectively, our results showed that AAV-mediated d2 depletion in the periapical lesion area can prevent the progression of endodontic disease and bone erosion while significantly reducing the inflammatory over-response. These findings show that the depletion of d2 simultaneously reduces bone resorption, enhances bone formation, and inhibits inflammation caused by periapical diseases and provide significant insights into the potential effectiveness of AAV-sh-d2-mediated d2 silencing gene therapy as a major endodontic treatment. Copyright © 2016. Published by Elsevier Inc.

  3. Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake.

    Science.gov (United States)

    Shimoda, Yoko; Okada, Shuichi; Yamada, Eijiro; Pessin, Jeffrey E; Yamada, Masanobu

    2015-10-01

    Tctex1d2 (Tctex1 domain containing 2) is an open reading frame that encodes for a functionally unknown protein that contains a Tctex1 domain found in dynein light chain family members. Examination of gene expression during adipogenesis demonstrated a marked increase in Tctex1d2 protein expression that was essentially undetectable in preadipocytes and markedly induced during 3T3-L1 adipocyte differentiation. Tctex1d2 overexpression significantly inhibited insulin-stimulated glucose transporter 4 (GLUT4) translocation and 2-deoxyglucose uptake. In contrast, Tctex1d2 knockdown significantly increased insulin-stimulated GLUT4 translocation and 2-deoxyglucose uptake. However, acute insulin stimulation (up to 30 min) in 3T3-L1 adipocytes with overexpression or knockdown of Tctex1d2 had no effect on Akt phosphorylation, a critical signal transduction target required for GLUT4 translocation. Although overexpression of Tctex1d2 had no significant effect on GLUT4 internalization, Tctex1d2 was found to associate with syntaxin 4 in an insulin-dependent manner and inhibit Doc2b binding to syntaxin 4. In addition, glucose-dependent insulinotropic polypeptide rescued the Tctex1d2 inhibition of insulin-stimulated GLUT4 translocation by suppressing the Tctex1d2-syntaxin 4 interaction and increasing Doc2b-Synatxin4 interactions. Taking these results together, we hypothesized that Tctex1d2 is a novel syntaxin 4 binding protein that functions as a negative regulator of GLUT4 plasma membrane translocation through inhibition of the Doc2b-syntaxin 4 interaction.

  4. Climatology of aerosol optical properties near the New England coast: preparation for the Two Column Aerosol Program (TCAP) field campaign

    Science.gov (United States)

    Berkowitz, C. M.; Chand, D.; Berg, L.; Kassianov, E.; Chapman, E.

    2011-12-01

    A key objective of the U.S. Department of Energy's Two Column Aerosol Project (TCAP) is to provide observations with which to evaluate the uncertainty in model simulations of aerosol optical depth (AOD) and their relation to estimates of aerosol radiative forcing and hence, to climate. To meet this objective, detailed ground-based aerosol measurements will be made via deployment of the ARM Mobile Facility (AMF) and the Mobile Aerosol Observing System (MAOS) at Cape Cod, Massachusetts for a 12-month period starting in the summer of 2012. These measurements will be supported by two scheduled aircraft campaigns using the ARM Aerial Facility's (AAF) G-1 aircraft and the NASA B-200 aircraft in July 2012 and again in February 2013. Each campaign will include sampling within two atmospheric columns using the aircrafts; one column will be located directly over, or very close to, Cape Cod, while the second will be over a relatively remote maritime location. This preliminary study presented here is designed to select the optimum location of the second, remote maritime atmospheric column using the mean and standard deviation of previously observed AODs from surface and space. An area with the large variability in AOD will be considered as a potential location for evaluation of the outputs from atmospheric models. In this study, we present regional climatological values of (1) AOD from the Moderate Resolution Imaging Spectrometer (MODIS) on Terra and Aqua satellite platforms; (2) single scattering albedo from the Multi-angle Imaging SpectroRadiometer (MISR) satellite; (3) the vertical distribution of aerosol layers from the Cloud Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite; and (4) the long term aerosol optical properties from the Aerosol Robotic Network (AERONET) surface sunphotometer at Martha's Vineyard, MA. Seasonal and geographical variations in these quantities will be analyzed and possible explanations will be presented based on

  5. Differential temperature preferences and thresholds among summer campers in Ontario's southern provincial parks: a Canadian case study in tourism climatology

    Science.gov (United States)

    Hewer, Micah J.; Scott, Daniel J.; Gough, William A.

    2017-08-01

    Weather and climate are important factors in relation to outdoor recreation and tourism. Camping and park visitation are weather sensitive activities very likely to be impacted by projected climate change. Temperature is the weather variable that has received the greatest attention within the tourism climatology literature and was the greatest predictor of park visitation within previous assessments. This study uses a stated climate preferences approach, relying on survey-based data, to explore differences for temperature preferences and thresholds among campers in Ontario parks. Statistically significant differences (at the 95% confidence level) in mean values for temperature preferences and thresholds were recorded based on various camper characteristics, such as the following: activity selection, age, gender, distance travelled, length of stay, life cycle stage, camping experience, and camping equipment. Swimmers preferred warmer day-time temperatures. Older campers preferred cooler temperatures and were more sensitive to heat stress, in the day and night time. Females preferred warmer temperatures and were less sensitive to heat stress during the night time. Campers who had travelled further distances to reach the park or planned to stay for longer periods were less sensitive to heat stress. Campers with children in their group preferred warmer temperatures and were less sensitive to heat stress, in the day and at night. Respondents with higher levels of camping experience preferred warmer temperatures at night. Tent campers were less sensitive to heat stress, in the day and at night. The results of this study have direct implications for previous and future climate change impact assessments on park visitation.

  6. Expected changes in future agro-climatological conditions in Northeast Thailand and their differences between general circulation models

    Science.gov (United States)

    Masaki, Yoshimitsu; Ishigooka, Yasushi; Kuwagata, Tsuneo; Goto, Shinkichi; Sawano, Shinji; Hasegawa, Toshihiro

    2011-12-01

    We have studied future changes in the atmospheric and hydrological environments in Northeast Thailand from the viewpoint of risk assessment of future cultural environments in crop fields. To obtain robust and reliable estimation for future climate, ten general circulation models under three warming scenarios, B1, A1B, and A2, were used in this study. The obtained change trends show that daily maximum air temperature and precipitation will increase by 2.6°C and 4.0%, respectively, whereas soil moisture will decrease by c.a. 1% point in volumetric water content at the end of this century under the A1B scenario. Seasonal contrasts in precipitation will intensify: precipitation increases in the rainy season and precipitation decreases in the dry season. Soil moisture will slightly decrease almost throughout the year. Despite a homogeneous increase in the air temperature over Northeast Thailand, a future decrease in soil water content will show a geographically inhomogeneous distribution: Soil will experience a relative larger decrease in wetness at a shallow depth on the Khorat plateau than in the surrounding mountainous area, reflecting vegetation cover and soil texture. The predicted increase in air temperature is relatively consistent between general circulation models. In contrast, relatively large intermodel differences in precipitation, especially in long-term trends, produce unwanted bias errors in the estimation of other hydrological elements, such as soil moisture and evaporation, and cause uncertainties in projection of the agro-climatological environment. Offline hydrological simulation with a wide precipitation range is one strategy to compensate for such uncertainties and to obtain reliable risk assessment of future cultural conditions in rainfed paddy fields in Northeast Thailand.

  7. A Central European precipitation climatology – Part I: Generation and validation of a high-resolution gridded daily data set (HYRAS

    Directory of Open Access Journals (Sweden)

    Monika Rauthe

    2013-07-01

    Full Text Available A new precipitation climatology (DWD/BfG-HYRAS-PRE is presented which covers the river basins in Germany and neighbouring countries. In order to satisfy hydrological requirements, the gridded dataset has a high spatial resolution of 1 km2 and a daily temporal resolution that is based on up to 6200 precipitation stations within the spatial domain. The period of coverage extends from 1951 to 2006 for which gridded, daily precipitation fields were calculated from the station data using the REGNIE method. This is a combination between multiple linear regression considering orographical conditions and inverse distance weighting. One of the main attributes of the REGNIE method is the preservation of the station values for their respective grid cells. A detailed validation of the data set using cross-validation and Jackknifing showed both seasonally- and spatially-dependent interpolation errors. These errors, through further applications of the HYRAS data set within the KLIWAS project and other studies, provide an estimate of its certainty and quality. The mean absolute error was found to be less than 2 mm/day, but with both spatial and temporal variability. Additionally, the need for a high station network density was shown. Comparisons with other existing data sets show good agreement, with areas of orographical complexity displaying the largest differences within the domain. These errors are largely due to uncertainties caused by differences in the interpolation method, the station network density available, and the topographical information used. First climatological applications are presented and show the high potential of this new, high-resolution data set. Generally significant increases of up to 40% in winter precipitation and light decreases in summer are shown, whereby the spatial variability of the strength and significance of the trends is clearly illustrated.

  8. A multi-decadal assessment of the performance of gauge- and model-based rainfall products over Saudi Arabia: Climatology, anomalies and trends

    KAUST Repository

    El Kenawy, Ahmed M.

    2015-05-15

    Many arid and semi-arid regions have sparse precipitation observing networks, which limits the capacity for detailed hydrological modelling, water resources management and flood forecasting efforts. The objective of this work is to evaluate the utility of relatively high-spatial resolution rainfall products to reproduce observed multi-decadal rainfall characteristics such as climatologies, anomalies and trends over Saudi Arabia. Our study compares the statistical characteristics of rainfall from 53 observatories over the reference period 1965-2005, with rainfall data from six widely used gauge-based products, including APHRODITE, GPCC, PRINCETON, UDEL, CRU and PREC/L. In addition, the performance of three global climate models (GCMs), including CCSM4, EC-EARTH and MRI-I-CGCM3, integrated as part of the Fifth Coupled Model Intercomparison Project (CMIP5), was also evaluated. Results indicate that the gauge-based products were generally skillful in reproducing rainfall characteristics in Saudi Arabia. In most cases, the gauge-based products were also able to capture the annual cycle, anomalies and climatologies of observed data, although significant inter-product variability was observed, depending on the assessment metric being used. In comparison, the GCM-based products generally exhibited poor performance, with larger biases and very weak correlations, particularly during the summertime. Importantly, all products generally failed to reproduce the observed long-term seasonal and annual trends in the region, particularly during the dry seasons (summer and autumn). Overall, this work suggests that selected gauge-based products with daily (APHRODITE and PRINCETON) and monthly (GPCC and CRU) resolutions show superior performance relative to other products, implying that they may be the most appropriate data source from which multi-decadal variations of rainfall can be investigated at the regional scale over Saudi Arabia. Discriminating these skillful products is

  9. 77 FR 52228 - Food Additives Permitted for Direct Addition to Food for Human Consumption; Vitamin D2

    Science.gov (United States)

    2012-08-29

    ... to Food for Human Consumption; Vitamin D2 Bakers Yeast AGENCY: Food and Drug Administration, HHS... regulations to provide for the safe use of vitamin D 2 bakers yeast as a source of vitamin D 2 and as a... vitamin D 2 per 100 grams (g) in the finished food. This action is in response to a petition filed...

  10. Affinity for dopamine D-2, D-3, and D-4 receptors of 2-aminotetralins. Relevance of D-2 agonist binding for determination of receptor subtype selectivity

    NARCIS (Netherlands)

    vanVliet, LA; Tepper, PG; Dijkstra, D; Damsma, G; Wikstrom, H; Pugsley, TA; Akunne, HC; Heffner, TG; Glase, SA; Wise, LD

    1996-01-01

    A series of 2-aminotetralins, substituted with a methoxy or a hydroxy group on the 5- or 7-position, and with varying N-alkyl or N-arylalkyl substituents, were prepared and evaluated in binding assays for human dopamine (DA) D-2, D-3, and D-4 receptors. Some members of this series were prepared in f

  11. Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines.

    Science.gov (United States)

    Nair, Venugopalan D; Olanow, C Warren; Sealfon, Stuart C

    2003-07-01

    Whereas dopamine agonists are known to provide symptomatic benefits for Parkinson's disease, recent clinical trials suggest that they might also be neuroprotective. Laboratory studies demonstrate that dopamine agonists can provide neuroprotective effects in a number of model systems, but the role of receptor-mediated signalling in these effects is controversial. We find that dopamine agonists have robust, concentration-dependent anti-apoptotic activity in PC12 cells that stably express human D(2L) receptors from cell death due to H(2)O(2) or trophic withdrawal and that the protective effects are abolished in the presence of D(2)-receptor antagonists. D(2) agonists are also neuroprotective in the nigral dopamine cell line SN4741, which express endogenous D(2) receptors, whereas no anti-apoptotic activity is observed in native PC12 cells, which do not express detectable D(2) receptors. Notably, the agonists studied differ in their relative efficacy to mediate anti-apoptotic effects and in their capacity to stimulate [(35)S]guanosine 5'-[gamma-thio]triphosphate ([(35)S]GTP[S]) binding, an indicator of G-protein activation. Studies with inhibitors of phosphoinositide 3-kinase (PI 3-kinase), extracellular-signal-regulated kinase or p38 mitogen-activated protein kinase indicate that the PI 3-kinase pathway is required for D(2) receptor-mediated cell survival. These studies indicate that certain dopamine agonists can complex with D(2) receptors to preferentially transactivate neuroprotective signalling pathways and to mediate increased cell survival.

  12. NeuroD2 regulates the development of hippocampal mossy fiber synapses

    Directory of Open Access Journals (Sweden)

    Wilke Scott A

    2012-02-01

    Full Text Available Abstract Background The assembly of neural circuits requires the concerted action of both genetically determined and activity-dependent mechanisms. Calcium-regulated transcription may link these processes, but the influence of specific transcription factors on the differentiation of synapse-specific properties is poorly understood. Here we characterize the influence of NeuroD2, a calcium-dependent transcription factor, in regulating the structural and functional maturation of the hippocampal mossy fiber (MF synapse. Results Using NeuroD2 null mice and in vivo lentivirus-mediated gene knockdown, we demonstrate a critical role for NeuroD2 in the formation of CA3 dendritic spines receiving MF inputs. We also use electrophysiological recordings from CA3 neurons while stimulating MF axons to show that NeuroD2 regulates the differentiation of functional properties at the MF synapse. Finally, we find that NeuroD2 regulates PSD95 expression in hippocampal neurons and that PSD95 loss of function in vivo reproduces CA3 neuron spine defects observed in NeuroD2 null mice. Conclusion These experiments identify NeuroD2 as a key transcription factor that regulates the structural and functional differentiation of MF synapses in vivo.

  13. A peptide disrupting the D2R-DAT interaction protects against dopamine neurotoxicity.

    Science.gov (United States)

    Su, Ping; Liu, Fang

    2017-09-01

    Dopamine reuptake from extracellular space to cytosol leads to accumulation of dopamine, which triggers neurotoxicity in dopaminergic neurons. Previous studies have shown that both dopamine D2 receptor (D2R) and dopamine transporter (DAT) are involved in dopamine neurotoxicity. However, blockade of either D2R or DAT causes side effects due to antagonism of other physiological functions of these two proteins. We previously found that DAT can form a protein complex with D2R and its cell surface expression is facilitated via D2R-DAT interaction, which regulates dopamine reuptake and intracellular dopamine levels. Here we found that an interfering peptide (DAT-S1) disrupting the D2R-DAT interaction protects neurons against dopamine neurotoxicity, and this effect is mediated by inhibiting DAT cell surface expression and inhibiting both caspase-3 and PARP-1 cleavage. This study demonstrates the role of the D2R-DAT complex in dopamine neurotoxicity and investigated the potential mechanisms, which might help better understand the mechanisms of dopamine neurotoxicity. The peptide may provide some insights to improve treatments for dopamine neurotoxicity and related diseases, such as Parkinson's disease, as well as methamphetamine- and 3,4-methsylenedioxy methamphetamine-induced neurotoxicity. Copyright © 2017. Published by Elsevier Inc.

  14. Dopamine D2 receptor expression in the corticotroph cells of the human normal pituitary gland.

    Science.gov (United States)

    Pivonello, Rosario; Waaijers, Marlijn; Kros, Johan M; Pivonello, Claudia; de Angelis, Cristina; Cozzolino, Alessia; Colao, Annamaria; Lamberts, Steven W J; Hofland, Leo J

    2017-08-01

    The dopamine D2 receptor is the main dopamine receptor expressed in the human normal pituitary gland. The aim of the current study was to evaluate dopamine D2 receptor expression in the corticotroph cell populations of the anterior lobe and pars intermedia, as well as posterior lobe of the human normal pituitary gland by immunohistochemistry. Human normal pituitary gland samples obtained from routine autopsies were used for the study. In all cases, histology together with immunostaining for adrenocorticotropic hormone, melanocyte-stimulating hormone, prolactin, and neurofilaments were performed and compared to the immunostaining for D2 receptor. D2 receptor was heterogeneously expressed in the majority of the cell populations of the anterior and posterior lobe as well as in the area localized between the anterior and posterior lobe, and arbitrary defined as "intermediate zone". This zone, characterized by the presence of nerve fibers included the residual pars intermedia represented by the colloid-filled cysts lined by the remnant melanotroph cells strongly expressing D2 receptors, and clusters of corticotroph cells, belonging to the anterior lobe but localized within the cysts and adjacent to the posterior lobe, variably expressing D2 receptors. D2 dopamine receptor is expressed in the majority of the cell populations of the human normal pituitary gland, and particularly, in the different corticotroph cell populations localized in the anterior lobe and the intermediate zone of the pituitary gland.

  15. Observations of long-lived H-2 and D-2 ions from non-thermal plasmas

    Science.gov (United States)

    Wang, Wei-Guo; Xu, Yong; Zhu, Ai-Min; Liu, Zhong-Wei; Liu, Xin; Yang, Xue-Feng

    2007-03-01

    Strong mass signals of H-2 and D-2 ions have been observed from low-pressure dielectric barrier discharge hydrogen and deuterium plasmas via molecular beam mass spectrometry. The observed H-2/H- and D-2/D- ratios (~0.35-0.4) are over five orders of magnitude higher than those observed by other techniques. The kinetic energy of H-2 and D-2 ions sampled from the plasmas was determined to be widely distributed, from a few eV to >100 eV, giving lifetimes greater than ~40 µs for H-2 and ~55 µs for D-2. The highest vib-rotational excitation of neutral H2 species in the plasma was determined to be about J = 0, v = 5 or J = 19, v = 0 via threshold ionization mass spectrometry. The possible pumping mechanisms for generating H-2 with further high J, required by the current high-rotation model, have been proposed. Similar to the lifetime of D-2 determined recently by another group, the H-2 lifetime observed in this work is about two orders of magnitude longer than that predicted by the current theoretical model. To explain these experimental observations regarding the meta-stability of long-lived H-2 and D-2 ions, the improved current high-rotation model or other new models, including the possible existence of some long-lived electronically excited states of H-2/D-2, need to be developed.

  16. Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose

    Science.gov (United States)

    Seeman, P

    2016-01-01

    Although all current antipsychotics act by interfering with the action of dopamine at dopamine D2 receptors, two recent reports showed that 800 to 1000 mg of cannabidiol per day alleviated the signs and symptoms of schizophrenia, although cannabidiol is not known to act on dopamine receptors. Because these recent clinical findings may indicate an important exception to the general rule that all antipsychotics interfere with dopamine at dopamine D2 receptors, the present study examined whether cannabidiol acted directly on D2 receptors, using tritiated domperidone to label rat brain striatal D2 receptors. It was found that cannabidiol inhibited the binding of radio-domperidone with dissociation constants of 11 nm at dopamine D2High receptors and 2800 nm at dopamine D2Low receptors, in the same biphasic manner as a dopamine partial agonist antipsychotic drug such as aripiprazole. The clinical doses of cannabidiol are sufficient to occupy the functional D2High sites. it is concluded that the dopamine partial agonist action of cannabidiol may account for its clinical antipsychotic effects. PMID:27754480

  17. Reducing Ventral Tegmental Dopamine D2 Receptor Expression Selectively Boosts Incentive Motivation.

    Science.gov (United States)

    de Jong, Johannes W; Roelofs, Theresia J M; Mol, Frédérique M U; Hillen, Anne E J; Meijboom, Katharina E; Luijendijk, Mieneke C M; van der Eerden, Harrie A M; Garner, Keith M; Vanderschuren, Louk J M J; Adan, Roger A H

    2015-08-01

    Altered mesolimbic dopamine signaling has been widely implicated in addictive behavior. For the most part, this work has focused on dopamine within the striatum, but there is emerging evidence for a role of the auto-inhibitory, somatodendritic dopamine D2 receptor (D2R) in the ventral tegmental area (VTA) in addiction. Thus, decreased midbrain D2R expression has been implicated in addiction in humans. Moreover, knockout of the gene encoding the D2R receptor (Drd2) in dopamine neurons has been shown to enhance the locomotor response to cocaine in mice. Therefore, we here tested the hypothesis that decreasing D2R expression in the VTA of adult rats, using shRNA knockdown, promotes addiction-like behavior in rats responding for cocaine or palatable food. Rats with decreased VTA D2R expression showed markedly increased motivation for both sucrose and cocaine under a progressive ratio schedule of reinforcement, but the acquisition or maintenance of cocaine self-administration were not affected. They also displayed enhanced cocaine-induced locomotor activity, but no change in basal locomotion. This robust increase in incentive motivation was behaviorally specific, as we did not observe any differences in fixed ratio responding, extinction responding, reinstatement or conditioned suppression of cocaine, and sucrose seeking. We conclude that VTA D2R knockdown results in increased incentive motivation, but does not directly promote other aspects of addiction-like behavior.

  18. 基于D2shepp统计法的非序列局部比对%Local Alignment-Free Sequences Based on D2shepp Statistics

    Institute of Scientific and Technical Information of China (English)

    刘雪梅; 文德华; 於黄忠; 高亚妮

    2012-01-01

    两条生物序列间的相似性比对是计算生物学探讨的主要问题之一,一种快速的依赖于k-元组的D2shepp统计法目前已被应用到非序列比对中.文中在零模型的基础上产生两条相互独立的随机序列,基于D2shepp统计法进行了两条序列的局部比对,找到局部比对的最优值并求和.在此基础上模拟了Power值的分布情况,并分析了不同k参数下的Power值分布.在相同参数下将文中提出的局部比对与已有的D2shepp统计的全局比对进行比较,发现局部比对D2shepp统计的Power值随着序列长度的增大而快速地接近于1,比全局比对更加快速、准确.%The similarities between two biological sequences is a major issue in computational biology, and a fast D2shepp statistics method based on the joint i-tuple content in two sequences has been used in the alignment-free sequence comparison. In this paper, two separate random sequences are generated based on the zero model, and their local alignment is conducted based on D2shepp statistics, thus obtaining the optimal values and the sum of these values. Then, the Power distribution is simulated and the distributions with different k values are analyzed. Finally, with the same parameters, the proposed local alignment is compared with the global alignment based on D2shepp statistics. It is found that the Power value of the proposed local alignment rapidly approaches 1 with the increase of the sequence length and that the proposed local alignment is quicker and more accurate than the global one.

  19. Deficient dopamine D2 receptor function causes renal inflammation independently of high blood pressure.

    Science.gov (United States)

    Zhang, Yanrong; Cuevas, Santiago; Asico, Laureano D; Escano, Crisanto; Yang, Yu; Pascua, Annabelle M; Wang, Xiaoyan; Jones, John E; Grandy, David; Eisner, Gilbert; Jose, Pedro A; Armando, Ines

    2012-01-01

    Renal dopamine receptors participate in the regulation of blood pressure. Genetic factors, including polymorphisms of the dopamine D(2) receptor gene (DRD2) are associated with essential hypertension, but the mechanisms of their contribution are incompletely understood. Mice lacking Drd2 (D(2)-/-) have elevated blood pressure, increased renal expression of inflammatory factors, and renal injury. We tested the hypothesis that decreased dopamine D(2) receptor (D(2)R) function increases vulnerability to renal inflammation independently of blood pressure, is an immediate cause of renal injury, and contributes to the subsequent development of hypertension. In D(2)-/- mice, treatment with apocynin normalized blood pressure and decreased oxidative stress, but did not affect the expression of inflammatory factors. In mouse RPTCs Drd2 silencing increased the expression of TNFα and MCP-1, while treatment with a D(2)R agonist abolished the angiotensin II-induced increase in TNF-α and MCP-1. In uni-nephrectomized wild-type mice, selective Drd2 silencing by subcapsular infusion of Drd2 siRNA into the remaining kidney produced the same increase in renal cytokines/chemokines that occurs after Drd2 deletion, increased the expression of markers of renal injury, and increased blood pressure. Moreover, in mice with two intact kidneys, short-term Drd2 silencing in one kidney, leaving the other kidney undisturbed, induced inflammatory factors and markers of renal injury in the treated kidney without increasing blood pressure. Our results demonstrate that the impact of decreased D(2)R function on renal inflammation is a primary effect, not necessarily associated with enhanced oxidant activity, or blood pressure; renal damage is the cause, not the result, of hypertension. Deficient renal D(2)R function may be of clinical relevance since common polymorphisms of the human DRD2 gene result in decreased D(2)R expression and function.

  20. Deficient dopamine D2 receptor function causes renal inflammation independently of high blood pressure.

    Directory of Open Access Journals (Sweden)

    Yanrong Zhang

    Full Text Available Renal dopamine receptors participate in the regulation of blood pressure. Genetic factors, including polymorphisms of the dopamine D(2 receptor gene (DRD2 are associated with essential hypertension, but the mechanisms of their contribution are incompletely understood. Mice lacking Drd2 (D(2-/- have elevated blood pressure, increased renal expression of inflammatory factors, and renal injury. We tested the hypothesis that decreased dopamine D(2 receptor (D(2R function increases vulnerability to renal inflammation independently of blood pressure, is an immediate cause of renal injury, and contributes to the subsequent development of hypertension. In D(2-/- mice, treatment with apocynin normalized blood pressure and decreased oxidative stress, but did not affect the expression of inflammatory factors. In mouse RPTCs Drd2 silencing increased the expression of TNFα and MCP-1, while treatment with a D(2R agonist abolished the angiotensin II-induced increase in TNF-α and MCP-1. In uni-nephrectomized wild-type mice, selective Drd2 silencing by subcapsular infusion of Drd2 siRNA into the remaining kidney produced the same increase in renal cytokines/chemokines that occurs after Drd2 deletion, increased the expression of markers of renal injury, and increased blood pressure. Moreover, in mice with two intact kidneys, short-term Drd2 silencing in one kidney, leaving the other kidney undisturbed, induced inflammatory factors and markers of renal injury in the treated kidney without increasing blood pressure. Our results demonstrate that the impact of decreased D(2R function on renal inflammation is a primary effect, not necessarily associated with enhanced oxidant activity, or blood pressure; renal damage is the cause, not the result, of hypertension. Deficient renal D(2R function may be of clinical relevance since common polymorphisms of the human DRD2 gene result in decreased D(2R expression and function.

  1. Threshold of Dopamine D2/3 Receptor Occupancy for Hyperprolactinemia in Older Patients With Schizophrenia.

    Science.gov (United States)

    Iwata, Yusuke; Nakajima, Shinichiro; Caravaggio, Fernando; Suzuki, Takefumi; Uchida, Hiroyuki; Plitman, Eric; Chung, Jun Ku; Mar, Wanna; Gerretsen, Philip; Pollock, Bruce G; Mulsant, Benoit H; Rajji, Tarek K; Mamo, David C; Graff-Guerrero, Ariel

    2016-12-01

    Although hyperprolactinemia carries a long-term risk of morbidity, the threshold of dopamine D2/3 receptor (D2/3R) occupancy for hyperprolactinemia has not been investigated in older patients with schizophrenia. Data were taken from a positron emission tomography (PET) study conducted between August 2007 and August 2015. The present post hoc study included 42 clinically stable outpatients with schizophrenia (DSM-IV) (mean ± SD age = 60.2 ± 6.7 years) taking olanzapine or risperidone. Subjects underwent [¹¹C]-raclopride PET scans to measure D2/3R occupancy before and after reducing their dose of antipsychotic by up to 40%. Blood samples were collected before each PET scan to measure prolactin levels. The relationship between prolactin levels and D2/3R occupancy was examined using stepwise linear regression analyses. The D2/3R occupancy thresholds for hyperprolactinemia were explored using Fisher exact tests. Prolactin levels decreased following dose reduction (mean ± SD = 24.1 ± 30.2 ng/mL to 17.2 ± 15.1 ng/mL; P D2/3R occupancy (β = .23, P = .04). Those with D2/3R occupancy of 66% or higher were more likely to have hyperprolactinemia than those with D2/3R occupancy lower than 66% (P = .03). Sensitivity, specificity, positive predictive value, and negative predictive value of this threshold were 0.44, 0.81, 0.78, and 0.48, respectively. We identified a D2/3R occupancy threshold for hyperprolactinemia of 66% in older patients with schizophrenia, which is lower than that reported in younger patients (73%) by other researchers. Our results suggest a higher sensitivity to antipsychotics in older patients. Prolactin levels could assist in the determination of appropriate antipsychotic dosing to minimize adverse effects. ClinicalTrials.gov identifier: NCT00716755.

  2. Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function.

    Science.gov (United States)

    King, G R; Ellinwood, E H; Silvia, C; Joyner, C M; Xue, Z; Caron, M G; Lee, T H

    1994-05-01

    Intermittent cocaine administration produces sensitization, whereas the continuous administration of cocaine produces tolerance to the effects of subsequent cocaine administration during withdrawal. The present study examined whether the effects of these two dosing regimens are related to alterations in the functional status of dopamine (DA) D2 receptors. In all experiments, rats were withdrawn for 7 days from a 14-day pretreatment regimen involving either continuous or intermittent cocaine administration. Experiments examined changes in the behavioral response to an autoreceptor-selective dose of apomorphine, the effects of sulpiride on electrically stimulated DA release in striatal brain slices and striatal D2 receptor binding, and mRNA levels. The results indicate that the continuous administration of cocaine produces findings consistent with D2 autoreceptor supersensitivity; there was enhanced inhibition of behavior after the autoreceptor-selective dose of apomorphine, decreased electrically stimulated DA release in the absence of sulpiride, and enhanced electrically stimulated DA release in the presence of sulpiride. However, there were no changes in postsynaptic D2 receptor binding or mRNA levels. Intermittent cocaine administration did not produce evidence of D2 autoreceptor subsensitivity: there was no decrease in inhibition of behavior after the autoreceptor-selective dose of apomorphine, no changes in electrically stimulated DA release in the absence or presence of D2 receptor blockade, and no change in the levels of D2 receptor binding; however, D2 mRNA levels were decreased by 22%. Overall, the present results are consistent with the hypothesis that the expression of tolerance induced by continuous cocaine administration is associated with D2 autoreceptor supersensitivity.

  3. Antarctic icebergs melt over the Southern Ocean : Climatology and impact on sea ice

    Science.gov (United States)

    Merino, Nacho; Le Sommer, Julien; Durand, Gael; Jourdain, Nicolas C.; Madec, Gurvan; Mathiot, Pierre; Tournadre, Jean

    2016-08-01

    Recent increase in Antarctic freshwater release to the Southern Ocean is suggested to contribute to change in water masses and sea ice. However, climate models differ in their representation of the freshwater sources. Recent improvements in altimetry-based detection of small icebergs and in estimates of the mass loss of Antarctica may help better constrain the values of Antarctic freshwater releases. We propose a model-based seasonal climatology of iceberg melt over the Southern Ocean using state-of-the-art observed glaciological estimates of the Antarctic mass loss. An improved version of a Lagrangian iceberg model is coupled with a global, eddy-permitting ocean/sea ice model and compared to small icebergs observations. Iceberg melt increases sea ice cover, about 10% in annual mean sea ice volume, and decreases sea surface temperature over most of the Southern Ocean, but with distinctive regional patterns. Our results underline the importance of improving the representation of Antarctic freshwater sources. This can be achieved by forcing ocean/sea ice models with a climatological iceberg fresh-water flux.

  4. Dynamical Tropopause Variability and Potential Vorticity Streamers in the Northern Hemisphere——A Climatological Analysis

    Institute of Scientific and Technical Information of China (English)

    Olivia MARTIUS; Cornelia SCHWIERZ; Michael SPRENGER

    2008-01-01

    This study presents a 44-year climatology of potential vorticity (PV) streamers in the Northern Hemi sphere based upon analyses of the ERA-40 reanalysis data set. A comparison to an existing 15-year clima tology yields very good agreement in the locations of PV streamer frequency maxima, but some differences are found in the amplitude of frequencies. The climatology is assessed with the focus on links between PV streamer frequencies and the synoptic- and planetary-scale variability of the dynamical tropopause. A comprehensive overview is provided on where (zonally) and when (seasonally) short-term variability throughout the extra-tropical and sub-tropical tropopause is enhanced or reduced. Several key processes that influence this variability are discussed. Baroclinic processes, for example, determine the variability in the storm-track areas in winter, whereas the Asian summer monsoon significantly influences the variability over Asia. The paper also describes links between the frequency of PV streamers in the extra-tropical and sub tropical tropopause and three major northern hemisphere teleconnection patterns. The observed changes in the PV streamer frequencies are closely related to concomitant variations of PV and its gradient within the tropopause region. During opposite phases of the North Atlantic Oscillation the location of the streamer frequency maxima shifts significantly in the Atlantic and European region in both the extra-tropics and subtropics. The influence of ENSO on the streamer frequencies is most pronounced in the subtropical Pacific.

  5. Climatological Processing and Product Development for the TRMM Ground Validation Program

    Science.gov (United States)

    Marks, D. A.; Kulie, M. S.; Robinson, M.; Silberstein, D. S.; Wolff, D. B.; Ferrier, B. S.; Amitai, E.; Fisher, B.; Wang, J.; Augustine, D.; Thiele, O.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    The Tropical Rainfall Measuring Mission (TRMM) satellite was successfully launched in November 1997.The main purpose of TRMM is to sample tropical rainfall using the first active spaceborne precipitation radar. To validate TRMM satellite observations, a comprehensive Ground Validation (GV) Program has been implemented. The primary goal of TRMM GV is to provide basic validation of satellite-derived precipitation measurements over monthly climatologies for the following primary sites: Melbourne, FL; Houston, TX; Darwin, Australia- and Kwajalein Atoll, RMI As part of the TRMM GV effort, research analysts at NASA Goddard Space Flight Center (GSFC) generate standardized rainfall products using quality-controlled ground-based radar data from the four primary GV sites. This presentation will provide an overview of TRMM GV climatological processing and product generation. A description of the data flow between the primary GV sites, NASA GSFC, and the TRMM Science and Data Information System (TSDIS) will be presented. The radar quality control algorithm, which features eight adjustable height and reflectivity parameters, and its effect on monthly rainfall maps, will be described. The methodology used to create monthly, gauge-adjusted rainfall products for each primary site will also be summarized. The standardized monthly rainfall products are developed in discrete, modular steps with distinct intermediate products. A summary of recently reprocessed official GV rainfall products available for TRMM science users will be presented. Updated basic standardized product results involving monthly accumulation, Z-R relationship, and gauge statistics for each primary GV site will also be displayed.

  6. Circulation response to ozone depletion depends on the zonal wind climatology

    Science.gov (United States)

    Lin, P.; Paynter, D.; Polvani, L. M.; Correa, G. J. P.; Ming, Y.; Ramaswamy, V.

    2016-12-01

    Circulation response to ozone depletion is studied in two General Climate Models: CAM3 and GFDL AM3. Both models are forced with identical ozone change and long time-slice simulations are performed to minimize the influence of internal variability. While both models simulate a lower stratospheric cooling and a poleward shift of extratropical jet with ozone depletion, the magnitudes of these changes are significantly different in the two models. The stronger stratospheric cooling simulated by CAM3 is due to a delayed onset of a negative dynamical feedback to polar stratospheric temperature changes, which is linked to its delayed breakdown of the polar vortex. By applying artificial zonal wind forcing to AM3 in the stratosphere, we are able to alter the zonal wind climatology over southern extratropical stratosphere in AM3 without directly affecting its own internal variability. This modified version of AM3 yields similar zonal wind climatology as CAM3. It also simulates stronger stratospheric cooling to the same ozone forcing compared to the original AM3. Since the delayed breakdown of the polar vortex is a common bias in most climate models, results of this study implies that the circulation response to ozone depletion simulated in most models might be overestimated.

  7. Climatology of the 500-hPa mediterranean storms associated with Saudi Arabia wet season precipitation

    Science.gov (United States)

    Almazroui, Mansour; Kamil, S.; Ammar, K.; Keay, Kevin; Alamoudi, A. O.

    2016-11-01

    The relationship between the Mediterranean 500-hPa storm tracks and wet season (November-April) rainfall over Saudi Arabia is investigated. The analysis is based on the application of an objective tracking scheme to the 6-hourly 500-hPa geopotential height ERA-Interim dataset (0.75° × 0.75°) for the period 1979-2012. The resulting tracks are then associated with the ERA-Interim rainfall events over Saudi Arabia. The association procedure showed that 34 % of the tracks are related to about 70 % of the rainfall. These associated tracks are used to construct climatology. A climatology of these storm tracks revealed that the eastern Mediterranean region is the preferred location for cyclogenesis with a maximum in the southwest parts of the Black Sea. The study also examined the mean radius, average intensity and average depth of the storms. The number of tracks in winter (December-February) is about 60 % of the total number which confirms the major contribution of the Mediterranean storms to rainfall over Saudi Arabia. A significant negative trend was found for storm cyclogenesis over the central Mediterranean, and the Black sea. A significant trend decrease in track density is observed over most of the northern parts of Saudi Arabia. The peaks of storm activities are observed in December and January in 1996, 1997 and 2009. Storm activity generally declines after 2000, especially in the second half of the wet season months (February-April).

  8. Examination of climatological wind patterns and simulated pollen dispersion in a complex island environment.

    Science.gov (United States)

    Viner, Brian J; Arritt, Raymond W; Westgate, Mark E

    2017-03-29

    Complex terrain creates small-scale circulations which affect pollen dispersion but may be missed by meteorological observing networks and coarse-grid meteorological models. On volcanic islands, these circulations result from differing rates of surface heating between land and sea as well as rugged terrain. We simulated the transport of bentgrass, ryegrass, and maize pollen from 30 sources within the agricultural regions of the Hawaiian island Kaua'i during climatological conditions spanning season conditions and the La Niña, El Niño, and neutral phases of the El Niño-Southern Oscillation. Both pollen size and source location had major effects on predicted dispersion over and near the island. Three patterns of pollen dispersion were identified in response to prevailing wind conditions: southwest winds transported pollen inland, funneling pollen grains through valleys; east winds transported pollen over the ocean, with dispersive tails for the smallest pollen grains following the mean wind and extending as far as the island of Ni'ihau 35 km away; and northeast winds moved pollen inland counter to the prevailing flow due to a sea breeze circulation that formed over the source region. These results are the first to predict the interactions between complex island terrain and local climatology on grass pollen dispersion. They demonstrate how numerical modeling can provide guidance for field trials by illustrating the common flow regimes present in complex terrain, allowing field trials to focus on areas where successful sampling is more likely to occur.

  9. Future changes in cyclone climatology over Europe as inferred from a regional climate simulation

    Energy Technology Data Exchange (ETDEWEB)

    Lionello, P. [University of Salento, Department of Material Science, Lecce (Italy); Boldrin, U. [University of Padua, Padua (Italy); Giorgi, F. [ICTP, Trieste (Italy)

    2008-05-15

    This study analyzes the cyclone climatology in regional climate model simulations of present day (1961-1990) and future (2071-2100, A2 and B2 emission scenarios) european climate conditions. The model domain covers the area from Scandinavia to Northern Africa and from the Eastern Atlantic to Russia at a horizontal grid spacing of 50 km. Compared to present day, in the A2 and B2 scenario conditions the annual average storm track intensity increases over the North-East Atlantic and decreases over Russia and the Eastern Mediterranean region. This overall change pattern is larger in the A2 than in the B2 simulations. However, the cyclone climatology change signal shows a large intermonthly variability and important differences across European regions. The largest changes are found over the North-East Atlantic, where the storm track intensity increases in winter and decreases in summer. A significant reduction of storm track intensity is found during late summer and autumn over the Mediterranean region, and from October to January over Russia. The number of cyclones decreases in future conditions throughout Europe, except over the Central Europe and Mediterranean regions in summer (where it increases). The frequency of intense cyclones and the depth of extreme cyclones increase over the North-East Atlantic, decrease over Russia and show an irregular response over the rest of the domain. (orig.)

  10. A global seasonal surface ocean climatology of phytoplankton types based on CHEMTAX analysis of HPLC pigments

    Science.gov (United States)

    Swan, Chantal M.; Vogt, Meike; Gruber, Nicolas; Laufkoetter, Charlotte

    2016-03-01

    Much advancement has been made in recent years in field data assimilation, remote sensing and ecosystem modeling, yet our global view of phytoplankton biogeography beyond chlorophyll biomass is still a cursory taxonomic picture with vast areas of the open ocean requiring field validations. High performance liquid chromatography (HPLC) pigment data combined with inverse methods offer an advantage over many other phytoplankton quantification measures by way of providing an immediate perspective of the whole phytoplankton community in a sample as a function of chlorophyll biomass. Historically, such chemotaxonomic analysis has been conducted mainly at local spatial and temporal scales in the ocean. Here, we apply a widely tested inverse approach, CHEMTAX, to a global climatology of pigment observations from HPLC. This study marks the first systematic and objective global application of CHEMTAX, yielding a seasonal climatology comprised of ~1500 1°×1° global grid points of the major phytoplankton pigment types in the ocean characterizing cyanobacteria, haptophytes, chlorophytes, cryptophytes, dinoflagellates, and diatoms, with results validated against prior regional studies where possible. Key findings from this new global view of specific phytoplankton abundances from pigments are a) the large global proportion of marine haptophytes (comprising 32±5% of total chlorophyll), whose biogeochemical functional roles are relatively unknown, and b) the contrasting spatial scales of complexity in global community structure that can be explained in part by regional oceanographic conditions. The results are publically accessible via

  11. GPS scintillations and total electron content climatology in the southern low, middle and high latitude regions

    Directory of Open Access Journals (Sweden)

    Luca Spogli

    2013-06-01

    Full Text Available In recent years, several groups have installed high-frequency sampling receivers in the southern middle and high latitude regions, to monitor ionospheric scintillations and the total electron content (TEC changes. Taking advantage of the archive of continuous and systematic observations of the ionosphere on L-band by means of signals from the Global Positioning System (GPS, we present the first attempt at ionospheric scintillation and TEC mapping from Latin America to Antarctica. The climatology of the area considered is derived through Ground-Based Scintillation Climatology, a method that can identify ionospheric sectors in which scintillations are more likely to occur. This study also introduces the novel ionospheric scintillation 'hot-spot' analysis. This analysis first identifies the crucial areas of the ionosphere in terms of enhanced probability of scintillation occurrence, and then it studies the seasonal variation of the main scintillation and TEC-related parameters. The results produced by this sophisticated analysis give significant indications of the spatial/ temporal recurrences of plasma irregularities, which contributes to the extending of current knowledge of the mechanisms that cause scintillations, and consequently to the development of efficient tools to forecast space-weather-related ionospheric events.

  12. Ultraviolet radiation climatology of the Earth`s surface and lower atmosphere. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Madronich, S. [National Center for Atmospheric Research, Boulder, CO (United States). Atmospheric Chemistry Div.; Stamnes, K. [Univ. of Alaska, Fairbanks, AK (United States). Dept. of Physics

    1999-03-01

    Ultraviolet (UV) radiation is the driving force of tropospheric chemistry and is furthermore detrimental to most living tissues. A three year modeling program was carried out to characterize the UV radiation in the lower atmosphere, with the objective of development a climatology of UV biologically active radiation, and of photo-dissociation reaction rates that are key to tropospheric chemistry. A comprehensive model, the Tropospheric Ultraviolet-Visible (TUV) model, was developed and made available to the scientific community. The model incorporates updated spectroscopic data, recent advances in radiative transfer theory, and allows flexible customization for the needs of different users. The TUV model has been used in conjunction with satellite-derived measurements of total atmospheric ozone and cloud amount, to develop a global climatology of UV radiation reaching the surface of the Earth. Initial validation studies are highly encouraging, showing that model predictions agree with direct measurements to ca. 5--10% at times when environmental conditions are well known, and to 10--30% for monthly averages when local environmental conditions can only be estimated remotely from satellite-based measurements. Additional validation studies are continuing.

  13. 3D-2D ultrasound feature-based registration for navigated prostate biopsy: A feasibility study

    OpenAIRE

    Selmi, Sonia,; Promayon, Emmanuel; Troccaz, Jocelyne

    2016-01-01

    International audience; The aim of this paper is to describe a 3D-2D ultrasound feature-based registration method for navigated prostate biopsy and its first results obtained on patient data. A system combining a low-cost tracking system and a 3D-2D registration algorithm was designed. The proposed 3D-2D registration method combines geometric and image-based distances. After extracting features from ultrasound images, 3D and 2D features within a defined distance are matched using an intensity...

  14. 3D-2D ultrasound feature-based registration for navigated prostate biopsy: a feasibility study.

    Science.gov (United States)

    Selmi, Sonia Y; Promayon, Emmanuel; Troccaz, Jocelyne

    2016-08-01

    The aim of this paper is to describe a 3D-2D ultrasound feature-based registration method for navigated prostate biopsy and its first results obtained on patient data. A system combining a low-cost tracking system and a 3D-2D registration algorithm was designed. The proposed 3D-2D registration method combines geometric and image-based distances. After extracting features from ultrasound images, 3D and 2D features within a defined distance are matched using an intensity-based function. The results are encouraging and show acceptable errors with simulated transforms applied on ultrasound volumes from real patients.

  15. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport

    Science.gov (United States)

    Schmidts, Miriam; Hou, Yuqing; Cortés, Claudio R.; Mans, Dorus A.; Huber, Celine; Boldt, Karsten; Patel, Mitali; van Reeuwijk, Jeroen; Plaza, Jean-Marc; van Beersum, Sylvia E. C.; Yap, Zhi Min; Letteboer, Stef J. F.; Taylor, S. Paige; Herridge, Warren; Johnson, Colin A.; Scambler, Peter J.; Ueffing, Marius; Kayserili, Hulya; Krakow, Deborah; King, Stephen M.; Beales, Philip L.; Al-Gazali, Lihadh; Wicking, Carol; Cormier-Daire, Valerie; Roepman, Ronald; Mitchison, Hannah M.; Witman, George B.; Al-Turki, Saeed; Anderson, Carl; Anney, Richard; Antony, Dinu; Asimit, Jennifer; Ayub, Mohammad; Barrett, Jeff; Barroso, Inês; Bentham, Jamie; Bhattacharya, Shoumo; Blackwood, Douglas; Bobrow, Martin; Bochukova, Elena; Bolton, Patrick; Boustred, Chris; Breen, Gerome; Brion, Marie-Jo; Brown, Andrew; Calissano, Mattia; Carss, Keren; Chatterjee, Krishna; Chen, Lu; Cirak, Sebhattin; Clapham, Peter; Clement, Gail; Coates, Guy; Collier, David; Cosgrove, Catherine; Cox, Tony; Craddock, Nick; Crooks, Lucy; Curran, Sarah; Daly, Allan; Danecek, Petr; Smith, George Davey; Day-Williams, Aaron; Day, Ian; Durbin, Richard; Edkins, Sarah; Ellis, Peter; Evans, David; Farooqi, I. Sadaf; Fatemifar, Ghazaleh; Fitzpatrick, David; Flicek, Paul; Floyd, Jamie; Foley, A. Reghan; Franklin, Chris; Futema, Marta; Gallagher, Louise; Gaunt, Tom; Geschwind, Daniel; Greenwood, Celia; Grozeva, Detelina; Guo, Xiaosen; Gurling, Hugh; Hart, Deborah; Hendricks, Audrey; Holmans, Peter; Huang, Jie; Humphries, Steve E.; Hurles, Matt; Hysi, Pirro; Jackson, David; Jamshidi, Yalda; Jewell, David; Chris, Joyce; Kaye, Jane; Keane, Thomas; Kemp, John; Kennedy, Karen; Kent, Alastair; Kolb-Kokocinski, Anja; Lachance, Genevieve; Langford, Cordelia; Lee, Irene; Li, Rui; Li, Yingrui; Ryan, Liu; Lönnqvist, Jouko; Lopes, Margarida; MacArthur, Daniel G.; Massimo, Mangino; Marchini, Jonathan; Maslen, John; McCarthy, Shane; McGuffin, Peter; McIntosh, Andrew; McKechanie, Andrew; McQuillin, Andrew; Memari, Yasin; Metrustry, Sarah; Min, Josine; Moayyeri, Alireza; Morris, James; Muddyman, Dawn; Muntoni, Francesco; Northstone, Kate; O'Donovan, Michael; O'Rahilly, Stephen; Onoufriadis, Alexandros; Oualkacha, Karim; Owen, Michael; Palotie, Aarno; Panoutsopoulou, Kalliope; Parker, Victoria; Parr, Jeremy; Paternoster, Lavinia; Paunio, Tiina; Payne, Felicity; Perry, John; Pietilainen, Olli; Plagnol, Vincent; Quail, Michael A.; Quaye, Lydia; Raymond, Lucy; Rehnström, Karola; Brent Richards, J.; Ring, Sue; Ritchie, Graham R S; Savage, David B.; Schoenmakers, Nadia; Semple, Robert K.; Serra, Eva; Shihab, Hashem; Shin, So-Youn; Skuse, David; Small, Kerrin; Smee, Carol; Soler, Artigas María; Soranzo, Nicole; Southam, Lorraine; Spector, Tim; St Pourcain, Beate; St. Clair, David; Stalker, Jim; Surdulescu, Gabriela; Suvisaari, Jaana; Tachmazidou, Ioanna; Tian, Jing; Timpson, Nic; Tobin, Martin; Valdes, Ana; van Kogelenberg, Margriet; Vijayarangakannan, Parthiban; Wain, Louise; Walter, Klaudia; Wang, Jun; Ward, Kirsten; Wheeler, Ellie; Whittall, Ros; Williams, Hywel; Williamson, Kathy; Wilson, Scott G.; Wong, Kim; Whyte, Tamieka; ChangJiang, Xu; Zeggini, Eleftheria; Zhang, Feng; Zheng, Hou-Feng

    2015-01-01

    The analysis of individuals with ciliary chondrodysplasias can shed light on sensitive mechanisms controlling ciliogenesis and cell signalling that are essential to embryonic development and survival. Here we identify TCTEX1D2 mutations causing Jeune asphyxiating thoracic dystrophy with partially penetrant inheritance. Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist Chlamydomonas, accompanied by destabilization of the retrograde IFT dynein motor. We thus define TCTEX1D2 as an integral component of the evolutionarily conserved retrograde IFT machinery. In complex with several IFT dynein light chains, it is required for correct vertebrate skeletal formation but may be functionally redundant under certain conditions. PMID:26044572

  16. Dynamic Alignment of D2 Enhanced by Two Few-cycle Pulses

    Institute of Scientific and Technical Information of China (English)

    Zeng-qiang Yang; Zhi-rong Guo; Bao-xiang Yin; Mao-zhu Sun

    2008-01-01

    Dynamic alignment of D2 induced by two few-cycle pulses was investigated by solving the time-dependent Schr(o)dinger equation numerically based on a rigid rotor model. The results show that alignment of D2 can be enhanced by two few-cycle pulses compared with the level achievable by a single fewcycle pulse as long as the time delay between two pulses is chosen properly, and the pulse duration of two lasers plays an important role in the aligning process of D2 molecules.

  17. Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance

    Directory of Open Access Journals (Sweden)

    Hasbi Ahmed

    2011-06-01

    Full Text Available Abstract Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance.

  18. MERIS albedo climatology for FRESCO+ O2 A-band cloud retrieval

    Directory of Open Access Journals (Sweden)

    Y. Zhou

    2011-03-01

    Full Text Available A new global albedo climatology for Oxygen A-band cloud retrievals is presented. The climatology is based on MEdium Resolution Imaging Spectrometer (MERIS Albedomap data and its favourable impact on the derivation of cloud fraction is demonstrated for the FRESCO+ (Fast Retrieval Scheme for Clouds from the Oxygen A-band algorithm. To date, a relatively coarse resolution (1° × 1° surface reflectance dataset from GOME (Global Ozone Monitoring Experiment Lambert-equivalent reflectivity (LER is used in FRESCO+. The GOME LER climatology does not account for the usually higher spatial resolution of UV/VIS instruments designed for trace gas remote sensing which introduces several artefacts, e.g. in regions with sharp spectral contrasts like coastlines or over bright surface targets. Therefore, MERIS black-sky albedo (BSA data from the period October 2002 to October 2006 were aggregated to a grid of 0.25° × 0.25° for each month of the year and for different spectral channels. In contrary to other available surface reflectivity datasets, MERIS includes channels at 754 nm and 775 nm which are located close to the spectral windows required for O2 A-band cloud retrievals. The MERIS BSA in the near-infrared compares well to Moderate Resolution Imaging Spectroradiometer (MODIS derived BSA with an average difference lower than 1% and a correlation coefficient of 0.98. However, when relating MERIS BSA to GOME LER a distinctly lower correlation (0.80 and enhanced scatter is found. Effective cloud fractions from two exemplary months (January and July 2006 of Scanning Imaging Absorption Spectrometer for Atmospheric Chartography (SCIAMACHY data were subsequently derived with FRESCO+ and compared to those from the Heidelberg Iterative Cloud Retrieval Utilities (HICRU algorithm. The MERIS climatology generally improves FRESCO+ effective cloud fractions. In particular small cloud fractions are in better agreement with HICRU. This is of importance for atmospheric

  19. Joint statistical correction of clutters, spokes and beam height for a radar climatology in Southern Germany

    Directory of Open Access Journals (Sweden)

    A. Wagner

    2012-04-01

    Full Text Available Extensive corrections of radar data are a crucial prerequisite for radar derived climatology. This kind of climatology demands a high level of data quality. Little deviations or minor systematic underestimations or overestimations in single radar images become a major cause of error in statistical analysis. First results of radar derived climatology have emerged over the last years, as data sets of appropriate extent are becoming available. Usually, these statistics are based on time series lasting up to ten years as storage of radar data was not achieved before.

    We present a new statistical post-correction scheme, which is based on seven years of radar data of the Munich weather radar (2000–2006 that is operated by DWD (German Weather Service. The typical correction algorithms for single radar images, such as clutter corrections, are used. Then an additional statistical post-correction based on the results of a climatological analysis from radar images follows. The aim of this statistical correction is to correct systematic errors caused by clutter effects or measuring effects but to conserve small-scale natural variations in space.

    The statistical correction is based on a thorough analysis of the different causes of possible errors for the Munich weather radar. This robust analysis revealed the following basic effects: the decrease of rain rate in relation to height and distance from the radar, clutter effects such as remaining clutter, eliminated clutter or shading effects from obstacles near the radar, visible as spokes, as well as the influence of the Bright Band. The correction algorithm is correspondingly based on these results. It consists of three modules. The first one is an altitude correction, which minimizes measuring effects. The second module corrects clutter effects and the third one realizes a mean adjustment to selected rain gauges. Two different radar products are used. The statistical analysis as well as

  20. D2 to D2

    Science.gov (United States)

    Ezhuthachan, Bobby; Mukhi, Sunil; Papageorgakis, Constantinos

    2008-07-01

    Starting from maximally supersymmetric (2+1)d Yang-Mills theory and using a duality transformation due to de Wit, Nicolai and Samtleben, we obtain the ghost-free Lorentzian 3-algebra theory that has recently been proposed to describe M2-branes. Our derivation does not invoke any properties of 3-algebras. Being derivable from SYM, the final theory is manifestly equivalent to it on-shell and should not be thought of as the IR limit that describes M2-branes, though it does have enhanced R-symmetry as well as superconformal symmetry off-shell.

  1. D2 to D2

    CERN Document Server

    Ezhuthachan, Bobby; Papageorgakis, Constantinos

    2008-01-01

    Starting from maximally supersymmetric (2+1)d Yang-Mills theory and using a duality transformation due to de Wit, Nicolai and Samtleben, we obtain the ghost-free Lorentzian 3-algebra theory that has recently been proposed to describe M2-branes. Our derivation does not invoke any properties of 3-algebras. Being derivable from SYM, the final theory is manifestly equivalent to it on-shell and should not be thought of as the IR limit that describes M2-branes, though it does have enhanced R-symmetry as well as superconformal symmetry off-shell.

  2. Relationship of frontal D2/3 binding potentials to cognition

    DEFF Research Database (Denmark)

    Fagerlund, Birgitte; Pinborg, Lars H; Mortensen, Erik Lykke;

    2013-01-01

    Studies of in vivo dopamine receptors in schizophrenia have mostly focused on D2 receptors in striatal areas or on D1 receptors in cortex. No previous study has examined the correlation between cortical dopamine D2/3 receptor binding potentials and cognition in schizophrenia patients. The objective...... was to examine this relation in the frontal cortex in first-episode, drug-naive schizophrenia patients. Based on preclinical and pharmacological evidence, we specifically expected to find a relation between D2/3 receptor binding potentials and set shifting. This was a cross-sectional, case-control study using...... single-photon emission computerized tomography with the D2/3-receptor ligand [123I]epidepride, co-registered with structural magnetic resonance imaging and correlated to cognitive measures. Participants were 24 antipsychotic-naive, first-episode schizophrenia patients and 20 healthy controls matched...

  3. ROLE OF D2 DOPAMINE RECEPTOR ON MODULATION OF THE LEUKOCYTE FORMULA IN RESTRAINT STRESSED RATS

    Directory of Open Access Journals (Sweden)

    Lucian Hritcu

    2006-08-01

    Full Text Available Dopamine is a monoamine neurotransmitter of both central and peripheral nervous system. Its role in the neural-immune communication has been discussed in the present study. Results reveal that in vivo blockade of D2 dopamine receptor by means of sulpiride, a selective antagonist for D2 dopamine receptor produce changes in functional activities of the immune effector cells. Adults rats pretreated once with LPS (a bacterial product (25µg/250µl, i.p., produce an immune response, were subjected to i.p. injection with sulpiride (4 mg/kg b.w., i.p., a selective antagonist for D2 dopamine receptors, after 3 days postimmunization. After 18 days later, we assessed the total leukocyte number, neutrophils, eosinophils and basophils number. In summary, we provide that D2 dopamine receptor blockade suppress or enhance the immune effector cells number in restraint stress.

  4. Effects of Lactobacillus acidophilus D2/CSL on laying hen performance

    National Research Council Canada - National Science Library

    Luigi Guidobono Cavalchini; Carla Orsi; Viviana Ferrazzi; Stefano Marelli; Maria Grazia Mangiagalli; Alberto Giardini; Daniele Gallazzi

    2010-01-01

    In order to evaluate the effects of dietary addition of probiotic strain Lactobacillus acidophilus D2/CSL on hen performance and egg quality, 160 commercial Hy-Line Brown pullets, 17 weeks old, were...

  5. The puzzling detection of D2CO in the molecular cloud L1689N

    Science.gov (United States)

    Ceccarelli, C.; Vastel, C.; Tielens, A. G. G. M.; Castets, A.; Boogert, A. C. A.; Loinard, L.; Caux, E.

    2002-01-01

    We present new observations of the D2CO emission towards the small cloud L1689N in the rho Ophiuchus complex. We surveyed five positions, three being a cut across a shock site and two probing the quiescent gas of the molecular cloud. We detected D2CO emission in the first three positions. The measured [D2CO]/[H2CO] is about 3%, whereas it is removed from the cold storage by the shock at the interface between the outflowing and quiescent gas. We review the predictions of the published models proposed to explain the observed high deuteration of formaldehyde. They fall in two basic schemes: gas phase and grain surface chemistry. None of the reviewed models is able to account for the observed [D2CO]/[H2CO] abundance ratio. A common characteristics shared by the models is apparently that all underestimate the atomic [D]/[H] ratio in the accreting gas.

  6. Selective Alignment of D2 Induced by Two Ultrashort Laser Pulses

    Institute of Scientific and Technical Information of China (English)

    Zeng-qiang Yang; Zhi-rong Guo; Gui-xian Ge

    2009-01-01

    The dynamics of molecular rotational wave packets of D2 induced by ultrashort laser pulses was investigated numerically by solving the time-dependent Schrodinger equation. Results show that an ultrashort pulse can manipulate a coherent rotational wave packet of D2 se-lectively. In the calculation, a first laser pulse was used to create a coherent rotational wave packet from an initial thermal ensemble of D2 at the temperature of 300 K. The second laser pulse was used to manipulate the rotational wave packet selectively around the first quarter and the three quarters revival. The alignment parameter and its Fourier transform amplitude both illustrate that the relative populations of even and odd rotational states in the final rotational wave packet of D2 can be manipulated by precisely selecting the time delay between the first and the second ultrashort pulse.

  7. Theoretical calculation of the shock compression properties of liquid H2 + D2 mixtures

    Institute of Scientific and Technical Information of China (English)

    陈其峰; 蔡灵仓; 陈栋泉; 经福谦

    1999-01-01

    Based on liquid variational perturbation theory with quantum mechanics correction, the effective exp-6 potential is adopted to compute the shock Hugoniot of liquid H2+D2 mixtures at different molar rations. An examination of the confidence of the above computation is performed by comparing experiments and calculations, in which similar calculation procedure used for H2+D2 is adopted for H2 and D2 each, since no experimental data are available to conduct this kind of comparison. Good agreement in both comparisons is found. This fact may look as if an indirect positive verification of calculation procedure was used here at least in the pressure and temperature domain covered by the experimental data of H2 and D2 used for comparison, numerically nearly up to 20 GPa and 104 K.

  8. Dopamine D2 receptor radiotracers [{sup 11}C](+)-PHNO and [{sup 3}H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo

    Energy Technology Data Exchange (ETDEWEB)

    McCormick, Patrick N. [Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S 1A8 (Canada)], E-mail: patrick.mccormick@camhpet.ca; Kapur, Shitij [Department of Psychiatry, University of Toronto, Toronto, Ontario, M5S 1A8 (Canada); PET Center, Center for Addiction and Mental Health, Toronto, Ontario, M5T 1R8 (Canada); Seeman, Philip [Department of Psychiatry, University of Toronto, Toronto, Ontario, M5S 1A8 (Canada); Department of Pharmacology, University of Toronto, Toronto, Ontario, M5S 1A8 (Canada); Wilson, Alan A. [Department of Psychiatry, University of Toronto, Toronto, Ontario, M5S 1A8 (Canada); PET Center, Center for Addiction and Mental Health, Toronto, Ontario, M5T 1R8 (Canada)

    2008-01-15

    Introduction: In vitro, the dopamine D2 receptor exists in two states, with high and low affinity for agonists. The high-affinity state is the physiologically active state thought to be involved in dopaminergic illnesses such as schizophrenia. The positron emission tomography radiotracer [{sup 11}C](+)-PHNO ([{sup 11}C](+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4] oxazin-9-o l), being a D2 agonist, should selectively label the high-affinity state at tracer dose and therefore be more susceptible to competition by agonist as compared to the antagonist [{sup 3}H]raclopride, which binds to both affinity states. Methods: We tested this prediction using ex vivo dual-radiotracer experiments in conscious rats. D2 antagonists (haloperidol or clozapine), a partial agonist (aripiprazole), a full agonist [(-)-NPA] or the dopamine-releasing drug amphetamine (AMPH) were administered to rats prior to an intravenous coinjection of [{sup 11}C](+)-PHNO and [{sup 3}H]raclopride. Rats were sacrificed 60 min after radiotracer injection. Striatum, cerebellum and plasma samples were counted for {sup 11}C and {sup 3}H. The specific binding ratio {l_brace}SBR, i.e., [%ID/g (striatum)-%ID/g (cerebellum)]/(%ID/g (cerebellum){r_brace} was used as the outcome measure. Results: In response to D2 antagonists, partial agonist or full agonist, [{sup 11}C](+)-PHNO and [{sup 3}H]raclopride SBRs responded indistinguishably in terms of both ED{sub 50} and Hill slope (e.g., (-)-NPA ED{sub 50} values are 0.027 and 0.023 mg/kg for [{sup 11}C](+)-PHNO and [{sup 3}H]raclopride, respectively). In response to AMPH challenge, [{sup 11}C](+)-PHNO and [{sup 3}H]raclopride SBRs were inhibited to the same degree. Conclusions: We have shown that the SBRs of [{sup 11}C](+)-PHNO- and [{sup 3}H]raclopride do not differ in their response to agonist challenge. These results do not support predictions of the in vivo binding behavior of a D2 agonist radiotracer and cast some doubt on the in vivo

  9. D2: major subgenotype of hepatitis B virus in Russia and the Baltic region.

    Science.gov (United States)

    Tallo, Tatjana; Tefanova, Valentina; Priimägi, Ljudmilla; Schmidt, Jelena; Katargina, Olga; Michailov, Michail; Mukomolov, Sergey; Magnius, Lars; Norder, Heléne

    2008-08-01

    Complete or almost complete hepatitis B virus (HBV) genomes were sequenced for 13 genotype A and 42 genotype D strains from the former USSR. The strains were classifiable within subgenotypes A2, D1, D2 and D3. Comparison of the deduced gene products for the four ORFs of 89 genotype D strains revealed 27 subgenotype-specific residues, and a region spanning residues 58-128 in the spacer region of the P gene could be used to distinguish between D1 and D4. This enabled the allocation to subgenotype of strains with partially sequenced genomes. D2 was dominating, while D3 was found in low frequency in the whole region. D1 was most prevalent in the Middle Asian Republics. Mean inter-subgenotype divergences between D1 and D2, D1 and D3 and D2 and D3 were 2.7, 3.4 and 3.4 %, respectively. The intra-subgenotype divergence was 0.4, 1.1, 1.0 and 1.8 % for A2, D1, D2 and D3, respectively. All D1 and D3 strains encoded subtype ayw2, whereas most D2 strains encoded ayw3. Two D2 strains encoded ayw4. Strains with identical S genes were closely related at the level of complete genomes and formed geographically specific clades with low intraclade divergences, possibly indicating past iatrogenic spread. It is not clear whether the finding of four subgenotypes in the area corresponds to separate introductions of the virus or to previous population migrations into the area. An earlier introduction of D3 compared with D2 was supported by its higher intra-subgenotype divergence, while the lower divergence within D1 is probably due to a more recent emergence.

  10. Plasma 25-hydroxyvitamin D2 and D3 levels and incidence of postoperative atrial fibrillation.

    Science.gov (United States)

    Skuladottir, G V; Cohen, A; Arnar, D O; Hougaard, D M; Torfason, B; Palsson, R; Indridason, O S

    2016-01-01

    Low circulating levels of total 25-hydroxyvitamin D (25(OH)D) have been associated with an increased risk of adverse effects after cardiac surgery. The metabolites, 25(OH)D2 and 25(OH)D3, provide a good index of vitamin D status. In this study, we examined the association between preoperative plasma levels of total 25(OH)D, 25(OH)D2 and 25(OH)D3 and the risk of postoperative atrial fibrillation (POAF) following open heart surgery. The levels of plasma 25(OH)D2 and 25(OH)D3 in 118 patients, who underwent coronary artery bypass grafting and/or valvular surgery, were measured immediately prior to surgery and on postoperative day 3 by liquid chromatography-tandem mass spectrometry. Patients who developed POAF had higher median plasma levels of 25(OH)D2 than those who remained in sinus rhythm (SR) (P = 0·003), but no significant difference was noted in levels of 25(OH)D3 or total 25(OH)D between the two groups (P > 0·05). By univariate analysis, patients with total 25(OH)D and 25(OH)D2 levels above the median had higher frequency of POAF (P D2 (P = 0·001), an association that was independent of confounding factors. In both the SR and POAF groups, the median plasma levels of 25(OH)D2, 25(OH)D3 and total 25(OH)D were lower (P D2 are associated with increased risk of POAF, while this is not the case for 25(OH)D3 or total 25(OH)D. The reason for these discrepant results is not clear but warrants further study.

  11. Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice

    OpenAIRE

    Ponnusamy, Ravikumar; Nissim, Helen A.; Barad, Mark

    2005-01-01

    Extinction of conditioned fear in animals is the explicit model of behavior therapy for human anxiety disorders, including panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. Based on previous data indicating that fear extinction in rats is blocked by quinpirole, an agonist of dopamine D2 receptors, we hypothesized that blockade of D2 receptors might facilitate extinction in mice, while agonists should block extinction, as they do in rats. One day after fear con...

  12. Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia.

    Science.gov (United States)

    Perez, Stephanie M; Lodge, Daniel J

    2012-11-01

    Based on the observation that antipsychotic medications display antagonist properties at dopamine D2-like receptors, aberrant dopamine signaling has been proposed to underlie psychosis in patients with schizophrenia. Thus, it is not surprising that considerable research has been devoted to understanding the mechanisms involved in the antipsychotic action of these compounds. It is important to note that the majority of these studies have been performed in "normal" experimental animals. Given that these animals do not possess the aberrant neuronal information processing typically associated with schizophrenia, the aim of the current study was to examine the dopamine D2 receptor system in a rodent model of schizophrenia. Here, we demonstrate that methylazoxymethanol acetate (MAM)-treated rats display an enhanced effect of quinpirole on dopamine neuron activity and an aberrant locomotor response to D2-like receptor activation, suggesting changes in postsynaptic D2-like receptor function. To better understand the mechanisms underlying the enhanced response to D2-like ligands in MAM-treated rats, we examined the expression of D2, D3, and dopamine transporter mRNA in the nucleus accumbens and ventral tegmental area by quantitative reverse transcription-polymerase chain reaction. MAM-treated rats displayed a significant increase in dopamine D3 receptor mRNA expression in the nucleus accumbens with no significant changes in the expression of the D2 receptor. Taken together, these data demonstrate robust alterations in dopamine D2-like receptor function in a rodent model of schizophrenia and provide evidence that preclinical studies examining the mechanisms of antipsychotic drug action should be performed in animal models that mirror aspects of the abnormal neuronal transmission thought to underlie symptoms of schizophrenia.

  13. The Roles of Dopamine D2 Receptor in the Social Hierarchy of Rodents and Primates

    OpenAIRE

    Yoshie Yamaguchi; Young-A. Lee; Akemi Kato; Emanuel Jas; Yukiori Goto

    2017-01-01

    Dopamine (DA) plays significant roles in regulation of social behavior. In social groups of humans and other animals, social hierarchy exists, which is determined by several behavioral characteristics such as aggression and impulsivity as well as social affiliations. In this study, we investigated the effects of pharmacological blockade of DA D2 receptor on social hierarchy of Japanese macaque and mouse social groups. We found acute administration of the D2 antagonist, sulpiride, in socially ...

  14. Dopaminergic isoquinolines with hexahydrocyclopenta[ij]-isoquinolines as D2-like selective ligands.

    Science.gov (United States)

    Párraga, Javier; Andujar, Sebastián A; Rojas, Sebastián; Gutierrez, Lucas J; El Aouad, Noureddine; Sanz, M Jesús; Enriz, Ricardo D; Cabedo, Nuria; Cortes, Diego

    2016-10-21

    Dopamine receptors (DR) ligands are potential drug candidates for treating neurological disorders including schizophrenia or Parkinson's disease. Three series of isoquinolines: (E)-1-styryl-1,2,3,4-tetrahydroisoquinolines (series 1), 7-phenyl-1,2,3,7,8,8a-hexahydrocyclopenta[ij]-IQs (HCPIQs) (series 2) and (E)-1-(prop-1-en-1-yl)-1,2,3,4- tetrahydroisoquinolines (series 3), were prepared to determine their affinity for both D1 and D2-like DR. The effect of different substituents on the nitrogen atom (methyl or allyl), the dioxygenated function (methoxyl or catechol), the substituent at the β-position of the THIQ skeleton, and the presence or absence of the cyclopentane motif, were studied. We observed that the most active compounds in the three series (2c, 2e, 3a, 3c, 3e, 5c and 5e) possessed a high affinity for D2-like DR and these remarkable features: a catechol group in the IQ-ring and the N-substitution (methyl or allyl). The series showed the following trend to D2-RD affinity: HCPIQs > 1-styryl > 1-propenyl. Therefore, the substituent at the β-position of the THIQ and the cyclopentane ring also modulated this affinity. Among these dopaminergic isoquinolines, HCPIQs stood out for unexpected selectivity to D2-DR since the Ki D1/D2 ratio reached values of 2465, 1010 and 382 for compounds 3a, 3c and 3e, respectively. None of the most active THIQs in D2 DR displayed relevant cytotoxicity in human neutrophils and HUVEC. Finally, and in agreement with the experimental data, molecular modeling studies on DRs of the most characteristic ligands of the three series revealed stronger molecular interactions with D2 DR than with D1 DR, which further supports to the encountered enhanced selectivity to D2 DR. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  15. Role of D2 dopamine receptors of the ventral pallidum in inhibitory avoidance learning.

    Science.gov (United States)

    Lénárd, László; Ollmann, Tamás; László, Kristóf; Kovács, Anita; Gálosi, Rita; Kállai, Veronika; Attila, Tóth; Kertes, Erika; Zagoracz, Olga; Karádi, Zoltán; Péczely, László

    2017-03-15

    In our present experiments, the role of D2 dopamine (DA) receptors of the ventral pallidum (VP) was investigated in one trial step-through inhibitory avoidance paradigm. Animals were shocked 3 times in the conditioning trial, with 0.5mA current for 1s. Subsequently bilateral microinjection of the D2 DA receptor agonist quinpirole was administered into the VP in three doses (0.1μg, 1.0μg or 5.0μg in 0.4μl saline). We also applied the D2 DA receptor antagonist sulpiride (0.4μg in 0.4μl saline) alone or 15min prior to the agonist treatment to elucidate whether the agonist effect was specific for the D2 DA receptors. Control animals received saline. In a supplementary experiment, it was also investigated whether application of the same conditioning method leads to the formation of short-term memory in the experimental animals. In the experiment with the D2 DA receptor agonist, only the 0.1μg quinpirole increased significantly the step-through latency during the test trials: retention was significant compared to the controls even 2 weeks after conditioning. The D2 DA receptor antagonist sulpiride pretreatment proved that the effect was due to the agonist induced activation of the D2 DA receptors of the VP. The supplementary experiment demonstrated that short-term memory is formed after conditioning in the experimental animals, supporting that the agonist enhanced memory consolidation in the first two experiments. Our results show that the activation of the D2 DA receptors in the VP facilitates memory consolidation as well as memory-retention in inhibitory avoidance paradigm. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Reproducing Kernel for D2(Ω, ρ) and Metric Induced by Reproducing Kernel

    Institute of Scientific and Technical Information of China (English)

    ZHAO Zhen Gang

    2009-01-01

    An important property of the reproducing kernel of D2(Ω, ρ) is obtained and the reproducing kernels for D2(Ω, ρ) are calculated when Ω = Bn × Bn and ρ are some special functions. A reproducing kernel is used to construct a semi-positive definite matrix and a distance function defined on Ω×Ω. An inequality is obtained about the distance function and the pseudodistance induced by the matrix.

  17. D2 dissection in laparoscopic and open gastrectomy for gastric cancer

    Science.gov (United States)

    Cui, Ming; Xing, Jia-Di; Yang, Wei; Ma, Yi-Yuan; Yao, Zhen-Dan; Zhang, Nan; Su, Xiang-Qian

    2012-01-01

    AIM: To evaluate the radicalness and safety of laparoscopic D2 dissection for gastric cancer. METHODS: Clinicopathological data from 209 patients with gastric cancer, who underwent radical gastrectomy with D2 dissection between January 2007 and February 2011, were analyzed retrospectively. Among these patients, 131 patients underwent laparoscopy-assisted gastrectomy (LAG) and 78 underwent open gastrectomy (OG). The parameters analyzed included operative time, blood loss, blood transfusion, morbidity, mortality, the number of harvested lymph nodes (HLNs), and pathological stage. RESULTS: There were no significant differences in sex, age, types of radical resection [radical proximal gastrectomy (PG + D2), radical distal gastrectomy (DG + D2) and radical total gastrectomy (TG + D2)], and stages between the LAG and OG groups (P > 0.05). Among the two groups, 127 cases (96.9%) and 76 cases (97.4%) had 15 or more HLNs, respectively. The average number of HLNs was 26.1 ± 11.4 in the LAG group and 24.2 ± 9.3 in the OG group (P = 0.233). In the same type of radical resection, there were no significant differences in the number of HLNs between the two groups (PG + D2: 21.7 ± 7.5 vs 22.4 ± 9.3; DG + D2: 25.7 ± 11.0 vs 22.3 ± 7.9; TG + D2: 30.9 ± 13.4 vs 29.3 ± 10.4; P > 0.05 for all comparisons). Tumor free margins were obtained in all cases. Compared with OG group, the LAG group had significantly less blood loss, but a longer operation time (P dissection is equivalent to OG in the number of HLNs, regardless of tumor location. Thus, this procedure can achieve the same radicalness as OG. PMID:22371644

  18. Modeling Cellular Networks with Full Duplex D2D Communication: A Stochastic Geometry Approach

    KAUST Repository

    Ali, Konpal S.

    2016-08-24

    Full-duplex (FD) communication is optimistically promoted to double the spectral efficiency if sufficient self-interference cancellation (SIC) is achieved. However, this is not true when deploying FD-communication in a large-scale setup due to the induced mutual interference. Therefore, a large-scale study is necessary to draw legitimate conclusions about gains associated with FD-communication. This paper studies the FD operation for underlay device-to-device (D2D) communication sharing the uplink resources in cellular networks. We propose a disjoint fine-tuned selection criterion for the D2D and FD modes of operation. Then, we develop a tractable analytical paradigm, based on stochastic geometry, to calculate the outage probability and rate for cellular and D2D users. The results reveal that even in the case of perfect SIC, due to the increased interference injected to the network by FD-D2D communication, having all proximity UEs transmit in FD-D2D is not beneficial for the network. However, if the system parameters are carefully tuned, non-trivial network spectral-efficiency gains (64% shown) can be harvested. We also investigate the effects of imperfect SIC and D2D-link distance distribution on the harvested FD gains.

  19. Loss of dopamine D2 receptors increases parvalbumin-positive interneurons in the anterior cingulate cortex.

    Science.gov (United States)

    Graham, Devon L; Durai, Heather H; Garden, Jamie D; Cohen, Evan L; Echevarria, Franklin D; Stanwood, Gregg D

    2015-02-18

    Disruption to dopamine homeostasis during brain development has been implicated in a variety of neuropsychiatric disorders, including depression and schizophrenia. Inappropriate expression or activity of GABAergic interneurons are common features of many of these disorders. We discovered a persistent upregulation of GAD67+ and parvalbumin+ neurons within the anterior cingulate cortex of dopamine D2 receptor knockout mice, while other GABAergic interneuron markers were unaffected. Interneuron distribution and number were not altered in the striatum or in the dopamine-poor somatosensory cortex. The changes were already present by postnatal day 14, indicating a developmental etiology. D2eGFP BAC transgenic mice demonstrated the presence of D2 receptor expression within a subset of parvalbumin-expressing cortical interneurons, suggesting the possibility of a direct cellular mechanism through which D2 receptor stimulation regulates interneuron differentiation or survival. D2 receptor knockout mice also exhibited decreased depressive-like behavior compared with wild-type controls in the tail suspension test. These data indicate that dopamine signaling modulates interneuron number and emotional behavior and that developmental D2 receptor loss or blockade could reveal a potential mechanism for the prodromal basis of neuropsychiatric disorders.

  20. The response to sulpiride in social anxiety disorder: D2 receptor function.

    Science.gov (United States)

    Bell, Caroline; Bhikha, Shamina; Colhoun, Helen; Carter, Frances; Frampton, Chris; Porter, Richard

    2013-02-01

    Some previous studies have suggested that patients with social anxiety disorder (SAD) have a hypoactive central dopaminergic system. Supporting this there have been reports from neuroimaging studies of reduced striatal D2 receptor binding in subjects with SAD. The aim of this study was to investigate D2 receptor sensitivity in patients with SAD compared with a group of matched, healthy controls using a neuroendocrine challenge with the selective D2 antagonist, sulpiride. D2 receptor function was assessed in 23 subjects with generalized SAD and 23 matched, healthy controls using a challenge with 400 mg of a selective D2 antagonist, sulpiride in a randomized, placebo-controlled, crossover design. Response to sulpiride was measured by the change in prolactin level and changes in self-rated measures of social anxiety, mood and the ability to experience pleasure. There was no significant difference in prolactin response to sulpiride between the two groups. Sulpiride resulted in no effect in either the SAD or healthy control group on measures of social anxiety, mood or the ability to experience pleasure. Contrary to our hypothesis, in this study we found no evidence of reduced D2 receptor function in subjects with SAD compared with healthy controls.

  1. Vitamin D2 supplementation amplifies eccentric exercise-induced muscle damage in NASCAR pit crew athletes.

    Science.gov (United States)

    Nieman, David C; Gillitt, Nicholas D; Shanely, R Andrew; Dew, Dustin; Meaney, Mary Pat; Luo, Beibei

    2013-12-20

    This study determined if 6-weeks vitamin D2 supplementation (vitD2, 3800 IU/day) had an influence on muscle function, eccentric exercise-induced muscle damage (EIMD), and delayed onset of muscle soreness (DOMS) in National Association for Stock Car Auto Racing (NASCAR) NASCAR pit crew athletes. Subjects were randomized to vitD2 (n=13) and placebo (n=15), and ingested supplements (double-blind) for six weeks. Blood samples were collected and muscle function tests conducted pre- and post-study (leg-back and hand grip dynamometer strength tests, body weight bench press to exhaustion, vertical jump, 30-s Wingate test). Post-study, subjects engaged in 90 min eccentric-based exercise, with blood samples and DOMS ratings obtained immediately after and 1- and 2-days post-exercise. Six weeks vitD2 increased serum 25(OH)D2 456% and decreased 25(OH)D3 21% versus placebo (peccentric exercise bout induced EIMD and DOMS, with higher muscle damage biomarkers measured in vitD2 compared to placebo (myoglobin 252%, 122% increase, respectively, p=0.001; creatine phosphokinase 24 h post-exercise, 169%, 32%, peccentric exercise.

  2. Sex Differences in Midbrain Dopamine D2-Type Receptor Availability and Association with Nicotine Dependence.

    Science.gov (United States)

    Okita, Kyoji; Petersen, Nicole; Robertson, Chelsea L; Dean, Andy C; Mandelkern, Mark A; London, Edythe D

    2016-11-01

    Women differ from men in smoking-related behaviors, among them a greater difficulty in quitting smoking. Unlike female smokers, male smokers have lower striatal dopamine D2-type receptor availability (binding potential, BPND) than nonsmokers and exhibit greater smoking-induced striatal dopamine release. Because dopamine D2-type autoreceptors in the midbrain influence striatal dopamine release, a function that has been linked to addiction, we tested for sex differences in midbrain dopamine D2-type receptor BPND and in relationships between midbrain BPND, nicotine dependence and striatal dopamine D2-type receptor BPND. Positron emission tomography was used with [(18)F]fallypride to measure BPND in a midbrain region, encompassing the substantia nigra and ventral tegmental area, in 18 daily smokers (7 women, 11 men) and 19 nonsmokers (10 women, 9 men). A significant sex-by-group interaction reflected greater midbrain BPND in female but not male smokers than in corresponding nonsmokers (F1, 32=5.089, p=0.03). Midbrain BPND was positively correlated with BPND in the caudate nucleus and putamen in nonsmokers and female smokers but not in male smokers and with nicotine dependence in female but not in male smokers. Striatal BPND was correlated negatively with nicotine dependence and smoking exposure. These findings extend observations on dopamine D2-type receptors in smokers and suggest a sex difference in how midbrain dopamine D2-type autoreceptors influence nicotine dependence.

  3. Phasic dopamine release drives rapid activation of striatal D2-receptors

    Science.gov (United States)

    Marcott, Pamela F; Mamaligas, Aphroditi A; Ford, Christopher P

    2014-01-01

    Summary Striatal dopamine transmission underlies numerous goal-directed behaviors. Medium spiny neurons (MSNs) are a major target of dopamine in the striatum. However, as dopamine does not directly evoke a synaptic event in MSNs, the time course of dopamine signaling in these cells remains unclear. To examine how dopamine release activates D2-receptors on MSNs, G-protein activated inwardly rectifying potassium (GIRK2; Kir 3.2) channels were virally overexpressed in the striatum and the resulting outward currents were used as a sensor of D2-receptor activation. Electrical and optogenetic stimulation of dopamine terminals evoked robust D2-receptor inhibitory post-synaptic currents (IPSCs) in GIRK2-expressing MSNs that occurred in under a second. Evoked D2-IPSCs could be driven by repetitive stimulation and were not occluded by background dopamine tone. Together, the results indicate that D2-receptors on MSNs exhibit functional low affinity and suggest that striatal D2-receptors can encode both tonic and phasic dopamine signals. PMID:25242218

  4. Imaging diffraction oscillations for inelastic collisions of NO radicals with He and D2

    Science.gov (United States)

    de Jongh, Tim; Karman, Tijs; Vogels, Sjoerd N.; Besemer, Matthieu; Onvlee, Jolijn; Suits, Arthur G.; Thompson, James O. F.; Groenenboom, Gerrit C.; van der Avoird, Ad; van de Meerakker, Sebastiaan Y. T.

    2017-07-01

    We present state-to-state differential cross sections for collisions of NO molecules (X2Π1 /2 ,j =1 /2 ,f ) with He atoms and ortho-D2 (j = 0) molecules as a function of collision energy. A high angular resolution obtained using the combination of Stark deceleration and velocity map imaging allows for the observation of diffraction oscillations in the angular scattering distributions. Differences in the differential cross sections and, in particular, differences in the angular spacing between individual diffraction peaks are observed. Since the masses of D2 and He are almost equal and since D2(j = 0) may be considered as a pseudo-atom, these differences directly reflect the larger size of D2 as compared to He. The observations are in excellent agreement with the cross sections obtained from quantum close-coupling scattering calculations based on accurate ab initio NO-He and NO-D2 potential energy surfaces. For the latter, we calculated a new NO-D2 potential energy surface.

  5. D2-Thr92Ala, thyroid hormone levels and biochemical hypothyroidism in preeclampsia.

    Science.gov (United States)

    Procopciuc, Lucia Maria; Caracostea, Gabriela; Hazi, Georgeta; Nemeti, Georgiana; Stamatian, Florin

    2017-02-01

    To identify if there is a relationship between the deiodinase D2-Thr92Ala genetic variant, thyroid hormone levels and biochemical hypothyroidism in preeclampsia. We genotyped 125 women with preeclampsia and 131 normal pregnant women using PCR-RFLP. Serum thyroid hormone levels were determined using ELISA. Our study showed higher TSH and FT4 levels and lower FT3 levels in women with preeclampsia compared to normal pregnant women, with statistical significance for women with mild and severe preeclampsia. The risk to develop pregnancy-induced hypertension (PIH), mild or severe preeclampsia was increased in carriers of at least one D2-Ala92 allele. TSH and FT4 levels were significantly higher and FT3 levels were significantly lower in preeclamptic women with severe preeclampsia if they carried the D2-Ala92 allele compared to non-carriers. Pregnant women with PIH and mild preeclampsia, carriers of at least one D2-Ala92 allele, delivered at lower gestational age neonates with a lower birth weight compared to non-carriers, but the results were statistically significant only in severe preeclampsia. The D2-Thr92Ala genetic variant is associated with the severity and the obstetric outcome of preeclampsia, and it also influences thyroid hormone levels. The study demonstrates non-thyroidal biochemical hypothyroidism - as a result of deiodination effects due to D2 genotypes.

  6. A Prototype Hail Detection Algorithm and Hail Climatology Developed with the Advanced Microwave Sounding Unit (AMSU)

    Science.gov (United States)

    Ferraro, Ralph; Beauchamp, James; Cecil, Dan; Heymsfeld, Gerald

    2015-01-01

    In previous studies published in the open literature, a strong relationship between the occurrence of hail and the microwave brightness temperatures (primarily at 37 and 85 GHz) was documented. These studies were performed with the Nimbus-7 SMMR, the TRMM Microwave Imager (TMI) and most recently, the Aqua AMSR-E sensor. This lead to climatologies of hail frequency from TMI and AMSR-E, however, limitations include geographical domain of the TMI sensor (35 S to 35 N) and the overpass time of the Aqua satellite (130 am/pm local time), both of which reduce an accurate mapping of hail events over the global domain and the full diurnal cycle. Nonetheless, these studies presented exciting, new applications for passive microwave sensors. Since 1998, NOAA and EUMETSAT have been operating the AMSU-A/B and the MHS on several operational satellites: NOAA-15 through NOAA-19; MetOp-A and -B. With multiple satellites in operation since 2000, the AMSU/MHS sensors provide near global coverage every 4 hours, thus, offering a much larger time and temporal sampling than TRMM or AMSR-E. With similar observation frequencies near 30 and 85 GHz and additionally three at the 183 GHz water vapor band, the potential to detect strong convection associated with severe storms on a more comprehensive time and space scale exists. In this study, we develop a prototype AMSU-based hail detection algorithm through the use of collocated satellite and surface hail reports over the continental U.S. for a 12-year period (2000-2011). Compared with the surface observations, the algorithm detects approximately 40 percent of hail occurrences. The simple threshold algorithm is then used to generate a hail climatology that is based on all available AMSU observations during 2000-11 that is stratified in several ways, including total hail occurrence by month (March through September), total annual, and over the diurnal cycle. Independent comparisons are made compared to similar data sets derived from other

  7. Towards a radar- and observation-based hail climatology for Germany

    Directory of Open Access Journals (Sweden)

    Thomas Junghänel

    2016-09-01

    Full Text Available In the German Strategy for Adaptation to Climate Change hail is identified as one of the major subjects of concern regarding transport infrastructure. Moreover hailstorms are a major threat to e.g. agriculture and the automobile industry causing significant economical damages and losses. Despite these significant hail-related meteorological risks no comprehensive observation-based hail climatology for Germany exists. In this study we present a new approach to this task, combining radar data with different kinds of hail reports, such as ground observation and agricultural insurance data. Preprocessing ensures the applicability of the radar data for the presented climatological analysis. In this sense a number of detection methods are applied to filter artefacts, especially clutter pixels and spokes that disrupt radar measurements. To construct a reliable hail climatology for Germany we process all information into a 10‑year based annual average number of hail days on a 1km×1km$1\\,\\text{km}\\times1\\,\\text{km}$ grid using a two-path hail criterion. While the first path combines a threshold of 50 dBZ with a hail report, the second path is based on a 55 dBZ threshold only. By adding radar data we increase the spatial representativity of the ground based hail reports and gain additional information in regions which lack observational data. Overall, the results are mainly determined by events derived from the first path (68 %. A validation of our dataset at 65 stations of Deutscher Wetterdienst shows that the method slightly underestimates the number of hail days, especially for mountainous regions. This results in a better adaption of the hail criterion to lowlands. The resulting hail frequency map shows an increase in the average number of hail days per year from north to south. In particular, hailstorms occur less frequently in the Central North German Plain and the Mecklenburg Coastal Lowland, whereas the highest number of hail days

  8. Lightning climatology over Jakarta, Indonesia, based on long-term surface operational, satellite, and campaign observations

    Science.gov (United States)

    Mori, Shuichi; Wu, Peiming; Yamanaka, Manabu D.; Hattori, Miki; Hamada, Jun-Ichi; Arbain, Ardhi A.; Lestari, Sopia; Sulistyowati, Reni; Syamsudin, Fadli

    2016-04-01

    Lightning frequency over Indonesian Maritime Continent (MC) is quite high (Petersen and Rutledge 2001, Christian et al. 2003, Takayabu 2006, etc). In particular, Bogor (south of Jakarta, west Jawa) had 322 days of lightning in one year (Guinness Book in 1988). Lightning causes serious damage on nature and society over the MC; forest fore, power outage, inrush/surge currents on many kinds of electronics. Lightning climatology and meso-scale characteristics of thunderstorm over the MC, in particular over Jakarta, where social damage is quite serious, were examined. We made Statistical analysis of lightning and thunderstorm based on TRMM Lightning Image Sensor (LIS) and Global Satellite Mapping of Precipitation (GSMaP) together with long-term operational surface observation data (SYNOP) in terms of diurnal, intraseasonal, monsoonal, and interannual variations. In addition, we carried out a campaign observation in February 2015 in Bogor to obtain meso-scale structure and dynamics of thunderstorm over Jakarta to focus on graupel and other ice phase particles inside by using an X-band dual-polarimetric (DP) radar. Recently, Virts et al. (2013a, b) showed comprehensive lightning climatology based on the World Wide Lightning Location Network (WWLLN). However, they also reported problems with its detection efficiency (< 10%) and small sampling frequency (< 0.1% of the time fly over tropics) by satellites. Therefore, we firstly examine in situ lightning data based on SYNOP observed by the Indonesian Agency for Meteorology, Climatology, and Geophysics (BMKG) because lightning is quite local and sporadic phenomena. We've started to analyze lightning characteristics over Jakarta region based on SYNOP as the ground truth data and GSMaP. Variability of lightning frequency around Jakarta was affected much by local conditions, e.g., topography (elevation) and proximity to the coastline. We confirmed the lightning frequency and its diurnal variation around Jakarta were much

  9. Extending the Purple Crow Lidar Temperature Climatology Above 100 km Altitude Using an Inversion Approach

    Science.gov (United States)

    Jalali, A.; Sica, R. J.; Argall, S.; McCullough, E. M.

    2013-12-01

    Temperature retrievals from Rayleigh-scattering lidar measurements have been performed using the algorithm given by Chanin and Hauchecorne (1980; henceforth CH) for the last 3 decades. Recently Khanna et al. have presented an inversion approach to retrieve atmospheric temperature profiles. This method uses a nonlinear inversion method with a Monte Carlo technique to determine the statistical uncertainties for the retrieved nightly average temperature profiles. Using this approach, Purple Crow Lidar temperature profiles can now be extended 10 km higher in altitude compared to those calculated with the CH method, with reduced systematic uncertainty. Argall and Sica (2007) used the CH method to produce a climatology of the Purple Crow Lidar measurements from 1994 to 2004 which was compared with the CIRA-86 model. The CH method integrates temperatures downward, and requires the assumption of a 'seed' pressure at the highest altitude, taken from a model. Geophysical variation here, in the lower thermosphere, is sufficiently large to cause temperature retrievals to be unreliable for the top 10 or more km; uncertainties due to this pressure assumption cause the top two scale heights of temperatures from each profile to be discarded until the retrieval is no longer sensitive to the seed pressure. Khanna et al. (2012) use an inversion approach which allows the corrected lidar photocount profile to be integrated upward, as opposed to downward as required by the CH method. Khanna et al. (2012) showed that seeding the retrieval at the lowest instead of top height allows a much smaller uncertainty in the contribution of the seed pressure to the temperature compared to integrating from the top of the profile. Two other benefits to seeding the retrieval at the lower altitudes (around 30 km) include reduced geophysical variability, and the availability of routine pressure measurements from radiosondes. This presentation will show an extension of the Khanna et al. (2012) comparison

  10. Magnetization of AN S=1/2 and 1 Ferrimagnetic Chain NiCu(pba)(D2O)32D2O in High Magnetic Fields

    Science.gov (United States)

    Hagiwara, M.; Narumi, Y.; Tatani, K.; Kindo, K.; Minami, K.

    2004-11-01

    We report the results of high field magnetization measurements on a powder sample of NiCu (pba)(D2O)32D2O (pba = 1,3-propylenebis(oxamato), C7H6N2O6) which is regarded as a ferrimagnetic chain composed of spins S = 1/2 and 1. From a fit of the susceptibility of this compound to numerical calculations (exact diagonalization for ten sites), we evaluated the exchange constant J/kB = 121 K. In the magnetization measurements at 10 K up to 50 T, we observed a magnetization plateau of about 1.1 μB/(formula unit) corresponding to about one-third of the saturated magnetization. The increase of the magnetization at low magnetic fields is discussed and compared with some calculations.

  11. Automatic localization of target vertebrae in spine surgery using fast CT-to-fluoroscopy (3D-2D) image registration

    Science.gov (United States)

    Otake, Y.; Schafer, S.; Stayman, J. W.; Zbijewski, W.; Kleinszig, G.; Graumann, R.; Khanna, A. J.; Siewerdsen, J. H.

    2012-02-01

    Localization of target vertebrae is an essential step in minimally invasive spine surgery, with conventional methods relying on "level counting" - i.e., manual counting of vertebrae under fluoroscopy starting from readily identifiable anatomy (e.g., the sacrum). The approach requires an undesirable level of radiation, time, and is prone to counting errors due to the similar appearance of vertebrae in projection images; wrong-level surgery occurs in 1 of every ~3000 cases. This paper proposes a method to automatically localize target vertebrae in x-ray projections using 3D-2D registration between preoperative CT (in which vertebrae are preoperatively labeled) and intraoperative fluoroscopy. The registration uses an intensity-based approach with a gradient-based similarity metric and the CMA-ES algorithm for optimization. Digitally reconstructed radiographs (DRRs) and a robust similarity metric are computed on GPU to accelerate the process. Evaluation in clinical CT data included 5,000 PA and LAT projections randomly perturbed to simulate human variability in setup of mobile intraoperative C-arm. The method demonstrated 100% success for PA view (projection error: 0.42mm) and 99.8% success for LAT view (projection error: 0.37mm). Initial implementation on GPU provided automatic target localization within about 3 sec, with further improvement underway via multi-GPU. The ability to automatically label vertebrae in fluoroscopy promises to streamline surgical workflow, improve patient safety, and reduce wrong-site surgeries, especially in large patients for whom manual methods are time consuming and error prone.

  12. Using 1D2D Hydrodynamic Modeling to Inform Restoration Planning in the Atchafalaya River Basin, Louisiana

    Science.gov (United States)

    Hayden-Lesmeister, A.; Remo, J. W.; Piazza, B.

    2015-12-01

    The Atchafalaya River (AR) in Louisiana is the principal distributary of the Mississippi River (MR), and its basin contains the largest contiguous area of baldcypress-water tupelo swamp forests in North America. After designation of the Atchafalaya River Basin (ARB) as a federal floodway following the destructive 1927 MR flood, it was extensively modified to accommodate a substantial portion of the MR flow (~25%) to mitigate flooding in southern Louisiana. These modifications and increased flows resulted in substantial incision along large portions of the AR, altering connectivity between the river and its associated waterbodies. As a result of incision, the hydroperiod has been substantially altered, which has contributed to a decline in ecological health of the ARB's baldcypress-water tupelo forests. While it is recognized that the altered hydroperiod has negatively affected natural baldcypress regeneration, it is unclear whether proposed projects designed to enhance flow connectivity will increase long-term survival of these forests. In this study, we have constructed a 1D2D hydrodynamic model using SOBEK 2.12 to realistically model key physical parameters such as residence times, inundation extent, water-surface elevations (WSELs), and flow velocities to increase our understanding of the ARB's altered hydroperiod and the consequences for baldcypress-water tupelo forests. While the model encompasses a majority of the ARB, our modeling effort is focused on the Flat Lake Water Management Unit located in the southern portion of the ARB, where it will also be used to evaluate flow connectivity enhancement projects within the management unit. We believe our 1D2D hybrid hydraulic modeling approach will provide the flexibility and accuracy needed to guide connectivity enhancement efforts in the ARB and may provide a model framework for guiding similar efforts along other highly-altered river systems.

  13. 基于WPD和(2D)2PCA的步态识别方法%Gait Recognition Using WPD and (2D)2PCA

    Institute of Scientific and Technical Information of China (English)

    杨新武; 杨跃伟; 翟飞

    2013-01-01

    为了提高步态识别率,在步态能量图(gait energy image,GEI)基础上,提出了基于小波包分解(waveletpacket decomposition,WPD)和完全主成分分析(two-directional two-dimensional principal component analysis,(2D)2PCA)的步态识别方法.该方法采用基于人体轮廓的GEI来解决步态数据量过大的问题,并采用WPD和(2D)2PCA进行步态特征提取,解决了已有基于小波变换的步态识别方法中高频分量丢失或维数过高问题.在NLPR步态数据库上对该方法进行了评测,并与经典方法进行了比较.实验结果表明:该方法具有更高的识别率和视角变化的鲁棒性.%To improve the gait recognition rate,a gait recognition method based on wavelet packet decomposition (WPD) and two-directional two-dimensional principal component analysis ((2D)2PCA)was proposed.In the method,gait energy image (GEI) of the body silhouette was firstly adopted to solve the problem of huge gait data.And then,WPD and (2D)2PCA were used to extract features to solve the problem existing in the gait recognition method based on wavelet transform at present:high frequency component loss or high dimension problem.The Experiment evaluation was conducted on NLPR gait database and compared with classical methods.Result shows that the proposed method has a higher recognition rate and is more robust to the change of view.

  14. The effect of D2 agonist versus D2 antagonist on the fear behavior in the male rats using plus-maze method: the prospective study

    Directory of Open Access Journals (Sweden)

    Sabzehkhah S

    2009-11-01

    Full Text Available "nBackground: Dopaminergic is the most important neurotransmitter is fear. The dopaminergic mesolimbic pathway has essential role in excitable behavior, and it's role in Parkinson disease. The aim of this research in study, the effect of dopaminergic pathway in fear response. "n"nMethods: The elevated plus maze was used in combination with the percentage of time spent in the open arms of the maze (OAT% and the percentage of entries into the open arms (OAE% to measure fear. Increases in the OAT% and OAE% indicate an anxiolytic effect (reduction in anxiety, whereas decreases in the OAE% and OAT% indicate an anxiogenic effect. After five days, the rats were injected with saline and different doses of sulpiride and Bromocriptine."n"nResults: Results showed that intracerebroventricular administration of sulpiride, in the doses of 5, 20μg/rat and bromocriptine, D2 agonist in doses 65, 95μg/rat produced a significant effect comparing to sham groups (p<0.05. While intracerebroventricular administration of sulpiride 15, 10μg/rat, and bromocriptine 70, 80μg/rat, did not show any significant effect comparing with sham group (p<0.05. In the current research intracerebroventricular administration of sulpiride, D2 antagonist at the doses of 5, 10, 15, 20μg/rat and Bromocriptine, D2 agonist in the doses of 65, 70, 80, 95μg/rat were used and theire effect on the fear behavior were studied. "n"nConclusions: The possible effect of Dopaminergic system in the fear process, especially D2 receptor increase fear.

  15. Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons.

    Science.gov (United States)

    Yapo, Cedric; Nair, Anu G; Clement, Lorna; Castro, Liliana R; Hellgren Kotaleski, Jeanette; Vincent, Pierre

    2017-08-07

    Brief dopamine events are critical actors of reward-mediated learning in the striatum; the intracellular cAMP-protein kinase A (PKA) response of striatal medium spiny neurons to such events was studied dynamically using a combination of biosensor imaging in mouse brain slices and in silico simulations. Both D1 and D2 medium spiny neurons can sense brief dopamine transients in the sub-micromolar range. While dopamine transients profoundly change cAMP levels in both types of medium spiny neurons, the PKA-dependent phosphorylation level remains unaffected in D2 neurons. At the level of PKA-dependent phosphorylation, D2 unresponsiveness depends on protein phosphatase-1 (PP1) inhibition by DARPP-32. Simulations suggest that D2 medium spiny neurons could detect transient dips in dopamine level. The phasic release of dopamine in the striatum determines various aspects of reward and action selection, but the dynamics of the dopamine effect on intracellular signalling remains poorly understood. We used genetically encoded FRET biosensors in striatal brain slices to quantify the effect of transient dopamine on cAMP or PKA-dependent phosphorylation levels, and computational modelling to further explore the dynamics of this signalling pathway. Medium-sized spiny neurons (MSNs), which express either D1 or D2 dopamine receptors, responded to dopamine by an increase or a decrease in cAMP, respectively. Transient dopamine showed similar sub-micromolar efficacies on cAMP in both D1 and D2 MSNs, thus challenging the commonly accepted notion that dopamine efficacy is much higher on D2 than on D1 receptors. However, in D2 MSNs, the large decrease in cAMP level triggered by transient dopamine did not translate to a decrease in PKA-dependent phosphorylation level, owing to the efficient inhibition of protein phosphatase 1 by DARPP-32. Simulations further suggested that D2 MSNs can also operate in a 'tone-sensing' mode, allowing them to detect transient dips in basal dopamine. Overall

  16. Determination of Vitamin D2 Content in Vitamin D2 and Calcium Hydrogen Phosphate Tablets by RP-HPLC%反相高效液相色谱法测定维D2磷酸氢钙片中维生素D2含量

    Institute of Scientific and Technical Information of China (English)

    冯国

    2013-01-01

    Objective To establish a RP-HPLC method for the content determination of vitamin D2 in Vitamin D2 and Calcium Hydrogen Phosphate Tablets.Methods The chromatographic column of AlltimaTM C18 was adopted with the mobile phase of acetonitrilemethanol(1∶9).The detection wavelength was set at 265 nm,the flow velocity was 1.0 mL/min and column temperature was 30 ℃.Results The sample size of vitamin D2 within the range of 0.005-0.065 μg(r=1.000 0)showed the good linearity with the peak area.The mean recovery rate was 99.38%,RSD =0.68% (n =9).Conclusion This method has the advantages of rapidness,simpleness,accuracy and low test cost,and can be used for the quality control of vitamin D2 in Vitamin D2 and Calcium Hydrogen Phosphate Tablets.%目的 建立测定维D2磷酸氢钙片中维生素D2含量的反相高效液相色谱法.方法 采用Alhima C18色谱柱(250 mm×4.6mm,5 μm),流动相为乙腈-甲醇(1∶9),检测波长为265 nm,流速为1.0 mL/min,柱温30℃.结果 维生素D2进样量在0.005~0.065 μg范围内与峰面积具有良好的线性关系,r=1.0000,平均回收率为99.38%,RSD=0.68%(n=9).结论 该法具有快速、简便、准确、检验成本低的优点,可用于维D2磷酸氢钙片中维生素D2的质量控制.

  17. High-power QCW microsecond-pulse solid-state sodium beacon laser with spiking suppression and D2b re-pumping.

    Science.gov (United States)

    Bian, Qi; Bo, Yong; Zuo, Jun-wei; Guo, Chuan; Xu, Chang; Tu, Wei; Shen, Yu; Zong, Nan; Yuan, Lei; Gao, Hong-wei; Peng, Qin-jun; Chen, Hong-bin; Feng, Lu; Jin, Kai; Wei, Kai; Cui, Da-fu; Xue, Sui-jian; Zhang, Yu-dong; Xu, Zu-yan

    2016-04-15

    A 65 W quasi-continuous-wave microsecond-pulse solid-state sodium beacon laser tuned to the sodium D2a line has been developed with a linewidth of 0.3 GHz, beam quality of M2=1.38, and pulse width of 120 μs at a repetition rate of 500 Hz by sum-frequency mixing 1319 and 1064 nm diode-pumped Nd:YAG master-oscillator power-amplifier systems. The laser wavelength stability is less than ±0.15 GHz through feedback controlling. The laser spiking due to relaxation oscillations is suppressed by inserting frequency doublers in both 1319 and 1064 nm oscillators. Sodium D2b re-pumping is accomplished by tuning the frequency of the electro-optic modulator with the right D2a-D2b offset. A bright sodium laser guide star with a photon return of 1820 photons/cm2/s was achieved with the laser system when a 32 W circular polarized beam was projected to the sky during our field test at the Xinglong Observatory.

  18. Lightning climatology of exoplanets and brown dwarfs guided by Solar System data

    CERN Document Server

    Hodosán, Gabriella; Asensio-Torres, Rubén; Vorgul, Irena; Rimmer, Paul B

    2016-01-01

    Clouds form on extrasolar planets and brown dwarfs where lightning could occur. Lightning is a tracer of atmospheric convection, cloud formation and ionization processes as known from the Solar System, and may be significant for the formation of prebiotic molecules. We study lightning climatology for the different atmospheric environments of Earth, Venus, Jupiter and Saturn. We present lightning distribution maps for Earth, Jupiter and Saturn, and flash densities for these planets and Venus, based on optical and/or radio measurements from the WWLLN and STARNET radio networks, the LIS/OTD satellite instruments, the Galileo, Cassini, New Horizons and Venus Express spacecraft. We also present flash densities calculated for several phases of two volcano eruptions, Eyjafjallaj\\"okull's (2010) and Mt Redoubt's (2009). We estimate lightning rates for sample, transiting and directly imaged extrasolar planets and brown dwarfs. Based on the large variety of exoplanets, six categories are suggested for which we use the ...

  19. The temporal and spatial relationship between NDVI and climatological parameters in Colorado

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper describes the spatial and temporal relationship between AVHRR/NDVI (Normalized Difference Vegetation Index) and climatological parameters (temperature and precipitation), which, in some sense, is influenced by topographical factors and land-cover types in Colorado. The correlation coefficients and partial correlation coefficients have been computed pixel by pixel over Colorado in order to analyze the relationship. The temporal variation and correlation of AVHRR/NDVI, temperature and precipitation were analyzed with a sampling method. The study reveals that there exists a close correspondence between monthly NDVI and temperature, which has strong impact from temperature on the changes of NDVI in Colorado. The spatial changes of NDVI are not influenced obviously by the precipitation since these two variables are different from each other in time series in Colorado. The study clearly revealed the spatial variation and its distribution patterns of relationship between NDVI and climatic parameters (temperature and precipitation) in Colorado.

  20. Physical approach to air pollution climatological modelling in a complex site

    Energy Technology Data Exchange (ETDEWEB)

    Bonino, G. (Torino, Universita; CNR, Istituto di Cosmo-Geofisica, Turin, Italy); Longhetto, A. (Ente Nazionale per l' Energia Elettrica, Centro di Ricerca Termica e Nucleare, Milan; CNR, Istituto di Cosmo-Geofisica, Turin, Italy); Runca, E. (International Institute for Applied Systems Analysis, Laxenburg, Austria)

    1980-09-01

    A Gaussian climatological model which takes into account physical factors affecting air pollutant dispersion, such as nocturnal radiative inversion and mixing height evolution, associated with land breeze and sea breeze regimes, has been applied to the topographically complex area of La Spezia. The measurements of the dynamic and thermodynamic structure of the lower atmosphere obtained by field experiments are utilized in the model to calculate the SO/sub 2/ seasonal average concentrations. The model has been tested on eight three-monthly periods by comparing the simulated values with the ones measured at the SO/sub 2/ stations of the local air pollution monitoring network. Comparison of simulated and measured values was satisfactory and proved the applicability of the model for urban planning and establishment of air quality strategies.

  1. Physical approach to air pollution climatological modelling in a complex site

    Energy Technology Data Exchange (ETDEWEB)

    Bonino, G. (Turin Univ. (Italy). Ist. di Fisica); Longhetto, A. (Ente Nazionale per l' Energia Elettrica, Milan (Italy). Centro di Ricerca Termica e Nucleare); Runca, E. (International Inst. for Applied Systems Analysis, Laxenburg (Austria))

    A Gaussian climatological model which takes into account physical factors affecting air pollutant dispersion, such as nocturnal radiative inversion and mixing height evolution, associated with land breeze and sea breeze regimes, respectively, has been applied to the topographically complex area of La Spezia (a basin surrounded by hilly terrain, located on the Italian coast). Results from the measurements of the dynamic and thermodynamic structure of the lower atmosphere, obtained by a series of field experiments, are utilized in the model to calculate SO/sub 2/ seasonal average concentrations. The model has been tested on eight three-monthly periods by comparing the simulated values with the ones measured at the SO/sub 2/ stations of the local air pollution monitoring network. Comparison of simulated and measured values was very satisfactory and proved the applicability of the implemented model for urban planning and establishment of air quality strategies also at a topographically complex site.

  2. High-resolution precipitation database for the last two centuries in Italy: climatologies and anomalies

    Science.gov (United States)

    Crespi, Alice; Brunetti, Michele; Maugeri, Maurizio

    2017-04-01

    The availability of gridded high-resolution spatial climatologies and corresponding secular records has acquired an increasing importance in the recent years both to research purposes and as decision-support tools in the management of natural resources and economical activities. High-resolution monthly precipitation climatologies for Italy were computed by gridding on a 30-arc-second-resolution Digital Elevation Model (DEM) the precipitation normals (1961-1990) obtained from a quality-controlled dataset of about 6200 stations covering the Italian surface and part of the Northern neighbouring regions. Starting from the assumption that the precipitation distribution is strongly influenced by orography, especially elevation, a local weighted linear regression (LWLR) of precipitation versus elevation was performed at each DEM cell. The regression coefficients for each cell were estimated by selecting the stations with the highest weights in which the distances and the level of similarity between the station cells and the considered grid cell, in terms of orographic features, are taken into account. An optimisation procedure was then set up in order to define, for each month and for each grid cell, the most suitable decreasing coefficients for the weighting factors which enter in the LWLR scheme. The model was validated by the comparison with the results provided by inverse distance weighting (IDW) applied both to station normals and to the residuals of a global regression of station normals versus elevation. In both cases, the LWLR leave-one-out reconstructions show the best agreement with the observed station normals, especially when considering specific station clusters (high elevation sites for example). After producing the high-resolution precipitation climatological field, the temporal component on the high-resolution grid was obtained by following the anomaly method. It is based on the assumption that the spatio-temporal structure of the signal of a

  3. Operational planning using Climatological Observations for Maritime Prediction and Analysis Support Service (COMPASS)

    Science.gov (United States)

    O'Connor, Alison; Kirtman, Benjamin; Harrison, Scott; Gorman, Joe

    2016-05-01

    The US Navy faces several limitations when planning operations in regard to forecasting environmental conditions. Currently, mission analysis and planning tools rely heavily on short-term (less than a week) forecasts or long-term statistical climate products. However, newly available data in the form of weather forecast ensembles provides dynamical and statistical extended-range predictions that can produce more accurate predictions if ensemble members can be combined correctly. Charles River Analytics is designing the Climatological Observations for Maritime Prediction and Analysis Support Service (COMPASS), which performs data fusion over extended-range multi-model ensembles, such as the North American Multi-Model Ensemble (NMME), to produce a unified forecast for several weeks to several seasons in the future. We evaluated thirty years of forecasts using machine learning to select predictions for an all-encompassing and superior forecast that can be used to inform the Navy's decision planning process.

  4. Actual and future climatological budget for Taubaté, SP, Brazil

    Directory of Open Access Journals (Sweden)

    Andréa Sanae Horikoshi

    2007-08-01

    Full Text Available The goal of this study was to determine the actual water budget for Taubaté, SP and investigate the future water availability. The Thornthwaite-Mather (1955 method was used for the climatological water budget combined with observed and simulated data of air temperature and precipitation. The future scenarios indicate an increase of temperature (ranging from + 0.5 °C to + 2.7 °C and precipitation (ranging from 80 to 150mm. These results will provoke an increase of the water deficit (ranging from 50 to 80mm and a decrease of the surplus of water (around 200mm. The increase of the precipitation will not be sufficient to compensate for the increase of the water demands from evapotranspiration

  5. Metrological challenges for measurements of key climatological observables, Part 4: Atmospheric relative humidity.

    Science.gov (United States)

    Lovell-Smith, J W; Feistel, R; Harvey, A H; Hellmuth, O; Bell, S A; Heinonen, M; Cooper, J R

    Water in its three ambient phases plays the central thermodynamic role in the terrestrial climate system. Clouds control Earth's radiation balance, atmospheric water vapour is the strongest "greenhouse" gas, and non-equilibrium relative humidity at the air-sea interface drives evaporation and latent heat export from the ocean. In this paper, we examine the climatologically relevant atmospheric relative humidity, noting fundamental deficiencies in the definition of this key observable. The metrological history of this quantity is reviewed, problems with its current definition and measurement practice are analysed, and options for future improvements are discussed in conjunction with the recent seawater standard TEOS-10. It is concluded that the International Bureau of Weights and Measures, (BIPM), in cooperation with the International Association for the Properties of Water and Steam, IAPWS, along with other international organisations and institutions, can make significant contributions by developing and recommending state-of-the-art solutions for this long standing metrological problem, such as are suggested here.

  6. Comparison of metabolism of vitamins D2 and D3 in children with nutritional rickets.

    Science.gov (United States)

    Thacher, Tom D; Fischer, Philip R; Obadofin, Michael O; Levine, Michael A; Singh, Ravinder J; Pettifor, John M

    2010-09-01

    Children with calcium-deficiency rickets may have increased vitamin D requirements and respond differently to vitamin D(2) and vitamin D(3). Our objective was to compare the metabolism of vitamins D(2) and D(3) in rachitic and control children. We administered an oral single dose of vitamin D(2) or D(3) of 1.25 mg to 49 Nigerian children--28 with active rickets and 21 healthy controls. The primary outcome measure was the incremental change in vitamin D metabolites. Baseline serum 25-hydroxyvitamin D [25(OH)D] concentrations ranged from 7 to 24 and 15 to 34 ng/mL in rachitic and control children, respectively (p vitamins D(2) and D(3) in children with rickets (29 ± 17 and 25 ± 11 ng/mL, respectively) and in control children (33 ± 13 and 31 ± 16 ng/mL, respectively). 1,25(OH)(2)D rose significantly (p vitamin D(2) and D(3) administration, respectively, in children with rickets. By contrast, control children had no significant increase in 1,25(OH)(2)D (19 ± 28 and 16 ± 38 pg/mL after vitamin D(2) and D(3) administration, respectively). We conclude that in the short term, vitamins D(2) and D(3) similarly increase serum 25(OH)D concentrations in rachitic and healthy children. A marked increase in 1,25(OH)(2)D in response to vitamin D distinguishes children with putative dietary calcium-deficiency rickets from healthy children, consistent with increased vitamin D requirements in children with calcium-deficiency rickets. © 2010 American Society for Bone and Mineral Research.

  7. Presynaptic action of neurotensin on dopamine release through inhibition of D2 receptor function

    Directory of Open Access Journals (Sweden)

    Trudeau Louis-Eric

    2009-08-01

    Full Text Available Abstract Background Neurotensin (NT is known to act on dopamine (DA neurons at the somatodendritic level to regulate cell firing and secondarily enhance DA release. In addition, anatomical and indirect physiological data suggest the presence of NT receptors at the terminal level. However, a clear demonstration of the mechanism of action of NT on dopaminergic axon terminals is lacking. We hypothesize that NT acts to increase DA release by inhibiting the function of terminal D2 autoreceptors. To test this hypothesis, we used fast-scan cyclic voltammetry (FCV to monitor in real time the axonal release of DA in the nucleus accumbens (NAcc. Results DA release was evoked by single electrical pulses and pulse trains (10 Hz, 30 pulses. Under these two stimulation conditions, we evaluated the characteristics of DA D2 autoreceptors and the presynaptic action of NT in the NAcc shell and shell/core border region. The selective agonist of D2 autoreceptors, quinpirole (1 μM, inhibited DA overflow evoked by both single and train pulses. In sharp contrast, the selective D2 receptor antagonist, sulpiride (5 μM, strongly enhanced DA release triggered by pulse trains, without any effect on DA release elicited by single pulses, thus confirming previous observations. We then determined the effect of NT (8–13 (100 nM and found that although it failed to increase DA release evoked by single pulses, it strongly enhanced DA release evoked by pulse trains that lead to prolonged DA release and engage D2 autoreceptors. In addition, initial blockade of D2 autoreceptors by sulpiride considerably inhibited further facilitation of DA release generated by NT (8–13. Conclusion Taken together, these data suggest that NT enhances DA release principally by inhibiting the function of terminal D2 autoreceptors and not by more direct mechanisms such as facilitation of terminal calcium influx.

  8. Dosage-dependent effect of dopamine D2 receptor activation on motor cortex plasticity in humans.

    Science.gov (United States)

    Fresnoza, Shane; Stiksrud, Elisabeth; Klinker, Florian; Liebetanz, David; Paulus, Walter; Kuo, Min-Fang; Nitsche, Michael A

    2014-08-06

    The neuromodulator dopamine plays an important role in synaptic plasticity. The effects depend on receptor subtypes, affinity, concentration level, and the kind of neuroplasticity induced. In animal experiments, dopamine D2-like receptor stimulation revealed partially antagonistic effects on plasticity, which might be explained by dosage dependency. In humans, D2 receptor block abolishes plasticity, and the D2/D3, but predominantly D3, receptor agonist ropinirol has a dosage-dependent nonlinear affect on plasticity. Here we aimed to determine the specific affect of D2 receptor activation on neuroplasticity in humans, because physiological effects of D2 and D3 receptors might differ. Therefore, we combined application of the selective D2 receptor agonist bromocriptine (2.5, 10, and 20 mg or placebo medication) with anodal and cathodal transcranial direct current stimulation (tDCS), which induces nonfocal plasticity, and with paired associative stimulation (PAS) generating a more focal kind of plasticity in the motor cortex of healthy humans. Plasticity was monitored by transcranial magnetic stimulation-induced motor-evoked potential amplitudes. For facilitatory tDCS, bromocriptine prevented plasticity induction independent from drug dosage. However, its application resulted in an inverted U-shaped dose-response curve on inhibitory tDCS, excitability-diminishing PAS, and to a minor degree on excitability-enhancing PAS. These data support the assumption that modulation of D2-like receptor activity exerts a nonlinear dose-dependent effect on neuroplasticity in the human motor cortex that differs from predominantly D3 receptor activation and that the kind of plasticity-induction procedure is relevant for its specific impact.

  9. Dopamine inhibits somatolactin gene expression in tilapia pituitary cells through the dopamine D2 receptors.

    Science.gov (United States)

    Jiang, Quan; Lian, Anji; He, Qi

    2016-07-01

    Dopamine (DA) is an important neurotransmitter in the central nervous system of vertebrates and possesses key hypophysiotropic functions. Early studies have shown that DA has a potent inhibitory effect on somatolactin (SL) release in fish. However, the mechanisms responsible for DA inhibition of SL gene expression are largely unknown. To this end, tilapia DA type-1 (D1) and type-2 (D2) receptor transcripts were examined in the neurointermediate lobe (NIL) of the tilapia pituitary by real-time PCR. In tilapia, DA not only was effective in inhibiting SL mRNA levels in vivo and in vitro, but also could abolish pituitary adenylate cyclase-activating polypeptide (PACAP)- and salmon gonadotropin-releasing hormone (sGnRH)-stimulated SL gene expression at the pituitary level. In parallel studies, the specific D2 receptor agonists quinpirole and bromocriptine could mimic the DA-inhibited SL gene expression. Furthermore, the D2 receptor antagonists domperidone and (-)-sulpiride could abolish the SL response to DA or the D2 agonist quinpirole, whereas D1 receptor antagonists SCH23390 and SKF83566 were not effective in this respect. In primary cultures of tilapia NIL cells, D2 agonist quinpirole-inhibited cAMP production could be blocked by co-treatment with the D2 antagonist domperidone and the ability of forskolin to increase cAMP production was also inhibited by quinpirole. Using a pharmacological approach, the AC/cAMP pathway was shown to be involved in quinpirole-inhibited SL mRNA expression. These results provide evidence that DA can directly inhibit SL gene expression at the tilapia pituitary level via D2 receptor through the AC/cAMP-dependent mechanism.

  10. Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1.

    Science.gov (United States)

    Espinoza, Stefano; Ghisi, Valentina; Emanuele, Marco; Leo, Damiana; Sukhanov, Ilya; Sotnikova, Tatiana D; Chieregatti, Evelina; Gainetdinov, Raul R

    2015-06-01

    Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) known to modulate dopaminergic system through several mechanisms. Mice lacking this receptor show a higher sensitivity to dopaminergic stimuli, such as amphetamine; however, it is not clear whether D1 or D2 dopamine receptors and which associated intracellular signaling events are involved in this modulation. In the striatum of TAAR1 knock out (TAAR1-KO mice) we found that D2, but not D1, dopamine receptors were over-expressed, both in terms of mRNA and protein levels. Moreover, the D2 dopamine receptor-related G protein-independent AKT/GSK3 signaling pathway was selectively activated, as indicated by the decrease of phosphorylation of AKT and GSK3β. The decrease in phospho-AKT levels, suggesting an increase in D2 dopamine receptor activity in basal conditions, was associated with an increase of AKT/PP2A complex, as revealed by co-immunoprecipitation experiments. Finally, we found that the locomotor activation induced by the D2 dopamine receptor agonist quinpirole, but not by the full D1 dopamine receptor agonist SKF-82958, was increased in TAAR1-KO mice. These data demonstrate pronounced supersensitivity of postsynaptic D2 dopamine receptors in the striatum of TAAR1-KO mice and indicate that a close interaction of TAAR1 and D2 dopamine receptors at the level of postsynaptic structures has important functional consequences. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Evidence That Sleep Deprivation Downregulates Dopamine D2R in Ventral Striatum in the Human Brain

    Energy Technology Data Exchange (ETDEWEB)

    Volkow N. D.; Fowler J.; Volkow, N.D.; Tomasi, D.; Wang, G.-J.; Fowler, J.S.; Logan, J.; Benveniste, H.; Kin, R.; Thanos, P.K.; Sergi F.

    2012-03-23

    Dopamine D2 receptors are involved with wakefulness, but their role in the decreased alertness associated with sleep deprivation is unclear. We had shown that sleep deprivation reduced dopamine D2/D3 receptor availability (measured with PET and [{sup 11}C]raclopride in controls) in striatum, but could not determine whether this reflected dopamine increases ([{sup 11}C]raclopride competes with dopamine for D2/D3 receptor binding) or receptor downregulation. To clarify this, we compared the dopamine increases induced by methylphenidate (a drug that increases dopamine by blocking dopamine transporters) during sleep deprivation versus rested sleep, with the assumption that methylphenidate's effects would be greater if, indeed, dopamine release was increased during sleep deprivation. We scanned 20 controls with [{sup 11}C]raclopride after rested sleep and after 1 night of sleep deprivation; both after placebo and after methylphenidate. We corroborated a decrease in D2/D3 receptor availability in the ventral striatum with sleep deprivation (compared with rested sleep) that was associated with reduced alertness and increased sleepiness. However, the dopamine increases induced by methylphenidate (measured as decreases in D2/D3 receptor availability compared with placebo) did not differ between rested sleep and sleep deprivation, and were associated with the increased alertness and reduced sleepiness when methylphenidate was administered after sleep deprivation. Similar findings were obtained by microdialysis in rodents subjected to 1 night of paradoxical sleep deprivation. These findings are consistent with a downregulation of D2/D3 receptors in ventral striatum with sleep deprivation that may contribute to the associated decreased wakefulness and also corroborate an enhancement of D2 receptor signaling in the arousing effects of methylphenidate in humans.

  12. Dopamine D2 receptor availability in opiate addicts at baseline and during naloxone precipitated withdrawal

    Energy Technology Data Exchange (ETDEWEB)

    Wang, G.J.; Volkow, N.D.; Logan, J. [Brookhaven National Lab., Upton, NY (United States)]|[SUNY, Stony Brook, NY (United States)]|[Psychiatry Services VAMC Northport, NY (United States)] [and others

    1996-05-01

    To determine if changes in dopamine activity contribute to the clinical presentation of opiate withdrawal we assessed dopamine (DA) D2 receptor availability in opiate-dependent subjects at baseline and during naloxone-precipitated withdrawal. DA D2 receptor availability was evaluated in eleven male heroine and methadone users using positron emission tomography (PET) and [11-C]raclopride and compared to eleven age matched male control subjects. Nine of the opiate-dependent subjects and two of the control were tested twice after placebo and naloxone (0.02 mg/kg) iv injection 7-10 min. prior to [11-C]raclopride. DA D2 receptor availability was measured using the ratio of the distribution volume in the region of interest (caudate, putamen and ventral striatum) to that in the cerebellum which is a function of B{sub max}/K{sub d}. DA D2 receptor availability in putamen was significantly lower in opiate-dependent subjects (3.44 {plus_minus} 0.4) than that in controls (3.97 {plus_minus} 0.45, p {ge} 0.009). Naloxone induced a short lasting withdrawal in all of the opiate-dependent subjects (79 {plus_minus} 17% of maximum withdrawal), but not in controls, with significant increase in pulse (p {le} 0.006), blood pressure (p {le} 0.0001), lacrimation (p {le} 0.01), muscle twitches (p {le} 0.01), annoyance (p {le} 0.005), anxiety (p {le} 0.0006), restlessness (p {le} 0.0005) and unhappiness (p {le} 0.001). DA D2 receptor availability in basal ganglia after naloxone administration was not different from that of baseline. These results document abnormalities in DA D2 receptors in opiate-dependent subjects. However, DA D2 availability did not change with naloxone-precipitated withdrawal.

  13. High-resolution satellite-gauge merged precipitation climatologies of the Tropical Andes

    Science.gov (United States)

    Manz, Bastian; Buytaert, Wouter; Zulkafli, Zed; Lavado, Waldo; Willems, Bram; Robles, Luis Alberto; Rodríguez-Sánchez, Juan-Pablo

    2016-02-01

    Satellite precipitation products are becoming increasingly useful to complement rain gauge networks in regions where these are too sparse to capture spatial precipitation patterns, such as in the Tropical Andes. The Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (TPR) was active for 17 years (1998-2014) and has generated one of the longest single-sensor, high-resolution, and high-accuracy rainfall records. In this study, high-resolution (5 km) gridded mean monthly climatological precipitation is derived from the raw orbital TPR data (TRMM 2A25) and merged with 723 rain gauges using multiple satellite-gauge (S-G) merging approaches. The resulting precipitation products are evaluated by cross validation and catchment water balances (runoff ratios) for 50 catchments across the Tropical Andes. Results show that the TPR captures major synoptic and seasonal precipitation patterns and also accurately defines orographic gradients but underestimates absolute monthly rainfall rates. The S-G merged products presented in this study constitute an improved source of climatological rainfall data, outperforming the gridded TPR product as well as a rain gauge-only product based on ordinary Kriging. Among the S-G merging methods, performance of inverse distance interpolation of satellite-gauge residuals was similar to that of geostatistical methods, which were more sensitive to gauge network density. High uncertainty and low performance of the merged precipitation products predominantly affected regions with low and intermittent precipitation regimes (e.g., Peruvian Pacific coast) and is likely linked to the low TPR sampling frequency. All S-G merged products presented in this study are available in the public domain.

  14. Weather patterns and hydro-climatological precursors of extreme floods in Switzerland since 1868

    Directory of Open Access Journals (Sweden)

    Peter Stucki

    2012-12-01

    Full Text Available The generation of 24 extreme floods in large catchments of the central Alps is analyzed from instrumental and documentary data, newly digitized observations of precipitation (DigiHom and 20th Century Reanalysis (20CR data. Extreme floods are determined by the 95th percentile of differences between an annual flood and a defined contemporary flood. For a selection of six events between 1868 and 1910, we descri