WorldWideScience

Sample records for clearance interval traffic signal cycle

  1. Comparison of Two Methods of Traffic Signal Design Cycle

    Directory of Open Access Journals (Sweden)

    María Liliana Alba Menéndez

    2013-02-01

    Full Text Available To satisfy the traffic demand in intersections, with safety and efficiency it is common to use a signallike control device, such that the right of using the common space of the intersections is assignedalternatively to the currents of such traffic flow that they cross. In Cuba, for the calculation of the cyclelength and the phases of the signal the Method of Poisson is used, based on the probability ofrandom arrivals of vehicles to the access point, developed in the 50th century. Presently many countriesuse the Method developed by Webster in England during 60th century, based on empiric observationsthen and unto today has proven effective, where an optimal cycle length is calculated, that is minimumdelays and better levels of service.In this study several intersections in Havana with high levels ofcomplexity were studied, the cycle length and the intervals of green were calculated by each method,the parameters that define the quality of the operation were determined in each method. The resultwill be vital in the strategic planning as see fit the National Centre of Traffic Engineering in thedesigning of traffic lights, with efficiency in road traffic.

  2. Traffic Signal Using Smart Agent System

    OpenAIRE

    Cheonshik Kim; You S. Hong

    2008-01-01

    In this research, we propose an electro-sensitive traffic light using the smart agent algorithm to reduce traffic congestion and traffic accidents. The multi-agent system approach can provide a new and preferable solution. The proposed method adaptively controls the cycle of traffic signals even though the traffic volume varies. Consequently, we reduce the car waiting time and start-up delay time using fuzzy control of feedback data. In particular, we have designed and implemented a system to...

  3. Traffic Signal Using Smart Agent System

    Directory of Open Access Journals (Sweden)

    Cheonshik Kim

    2008-01-01

    Full Text Available In this research, we propose an electro-sensitive traffic light using the smart agent algorithm to reduce traffic congestion and traffic accidents. The multi-agent system approach can provide a new and preferable solution. The proposed method adaptively controls the cycle of traffic signals even though the traffic volume varies. Consequently, we reduce the car waiting time and start-up delay time using fuzzy control of feedback data. In particular, we have designed and implemented a system to create optimum traffic signals in congested conditions. The effectiveness of this method was shown through simulation of multiple intersections.

  4. System and method for traffic signal timing estimation

    KAUST Repository

    Dumazert, Julien

    2015-12-30

    A method and system for estimating traffic signals. The method and system can include constructing trajectories of probe vehicles from GPS data emitted by the probe vehicles, estimating traffic signal cycles, combining the estimates, and computing the traffic signal timing by maximizing a scoring function based on the estimates. Estimating traffic signal cycles can be based on transition times of the probe vehicles starting after a traffic signal turns green.

  5. Distributed traffic signal control using fuzzy logic

    Science.gov (United States)

    Chiu, Stephen

    1992-01-01

    We present a distributed approach to traffic signal control, where the signal timing parameters at a given intersection are adjusted as functions of the local traffic condition and of the signal timing parameters at adjacent intersections. Thus, the signal timing parameters evolve dynamically using only local information to improve traffic flow. This distributed approach provides for a fault-tolerant, highly responsive traffic management system. The signal timing at an intersection is defined by three parameters: cycle time, phase split, and offset. We use fuzzy decision rules to adjust these three parameters based only on local information. The amount of change in the timing parameters during each cycle is limited to a small fraction of the current parameters to ensure smooth transition. We show the effectiveness of this method through simulation of the traffic flow in a network of controlled intersections.

  6. Dual use of LED traffic signal system

    OpenAIRE

    Cheung, SW; Yang, ES; Tam, YY; Man, CW; D. Yang

    1999-01-01

    The dual use, signaling and communication, of LED traffic signal system is described and analyzed. The primary function of a traffic light system is to give traffic and pedestrian signals. A prototype of LED traffic signal head is developed to perform a secondary function: communication. A wireless communication link is set up using the LED traffic signal head as the transmitter. The LEDs are modulated to transmit information-carrying light. The receiver uses a silicon photodiode to detect th...

  7. Autonomous Traffic Signal Control Model with Neural Network Analogy

    CERN Document Server

    Ohira, T

    1997-01-01

    We propose here an autonomous traffic signal control model based on analogy with neural networks. In this model, the length of cycle time period of traffic lights at each signal is autonomously adapted. We find a self-organizing collective behavior of such a model through simulation on a one-dimensional lattice model road: traffic congestion is greatly diffused when traffic signals have such autonomous adaptability with suitably tuned parameters. We also find that effectiveness of the system emerges through interactions between units and shows a threshold transition as a function of proportion of adaptive signals in the model.

  8. Signal Groups of Compatible Graph in Traffic Control Problems

    Directory of Open Access Journals (Sweden)

    Arun Kumar Baruah

    2012-07-01

    Full Text Available Signal Groups of a compatibility graph is used to solve conflict between the traffic streams and hence can be used as a solution for traffic control problem at an intersection. In this paper we have considered cliques of the compatible graph as signal groups and the set of signal groups which can simultaneously move at an intersection is taken in a phase. Phasing of traffic lights is done by splitting the cycle time among these phases so that each set of signal group is allowed to move once in the cycle.

  9. Traffic Signals in Motorcycle Dependent Cities

    OpenAIRE

    Do, Quoc Cuong

    2009-01-01

    Traffic signal control was first invented in 1868 in Great Britain. Then, it has quickly spread across many other countries, what are now usually developed countries. Therefore, during a long history of development, traffic signals usually have been dealing with traffic in which four-wheel vehicles play an important role in motorised traffic. However, as a result of an unequal development among countries, many Motorcycle Dependent Cities (MDCs) nowadays still exist mostly in the developing co...

  10. Influences of overtaking on two-lane traffic with signals

    Science.gov (United States)

    Chen, Chen; Chen, Jianqiao; Guo, Xiwei

    2010-01-01

    Based on the cellular automata method (CA method), two-lane traffic flow with the consideration of overtaking is investigated. Discrete equations are proposed to describe the traffic dynamics by using the rules of CA model. Influences of signal cycle time ( ts) and vehicular density (ρ) on the mean velocity and mean overtaking times of the traffic flow are discussed. The effects of slow vehicles and road barricades on the traffic flow are also studied. Simulation results shows that the vehicular density and the signal cycle time have significant influences on the traffic flow. The mean velocity of the traffic flow could keep a comparatively large value when ρ≤0.45. For a certain value of ρ, displays a serrated fluctuation with ts. Therefore, there may exist a certain combination of ρ and ts which optimizes the traffic flow efficiency. As compared with the results in Nagatani (2009) [7], the model proposed here and the simulation results which took into account the effects of signal cycle time, slow vehicles, and road barricades on the traffic flow with overtaking allowed, can reflect the situation of traffic flow in a more realistic way.

  11. Light signals for road traffic control.

    OpenAIRE

    Schreuder, D.A.

    1981-01-01

    Signals for road traffic control are a major constituent of the modern traffic scene, particularly in built-up areas. A vast amount of research has been executed in the last two decennia, resulting in a fairly generally accepted view on what the requirements for effective traffic lights are. For the French translation see B 19780

  12. Fuzzy Multiobjective Traffic Light Signal Optimization

    OpenAIRE

    N. Shahsavari Pour; H. Asadi; M. Pour Kheradmand

    2013-01-01

    Traffic congestion is a major concern for many cities throughout the world. In a general traffic light controller, the traffic lights change at a constant cycle time. Hence it does not provide an optimal solution. Many traffic light controllers in current use are based on the “time-of-the-day” scheme, which use a limited number of predetermined traffic light patterns and implement these patterns depending upon the time of the day. These automated systems do not provide an optimal control for ...

  13. Calculation features of traffic light regulation regimesat the signal group control

    OpenAIRE

    Єресов, Володимир Іванович; Трушевський, Вячеслав Едуардович

    2014-01-01

    The differences between the existing technologies of traffic light control by phases and signal groups were determined in the paper. It was proved that the signal group control technology is more perfect and to a greater extent corresponds to the changing traffic conditions at intersections. Approach for compiling the traffic light regulation cycle structure based on the analysis of conflict of traffic and pedestrian flows, taking into account traffic volume, the number of road accidents in t...

  14. A Two-Stage Fuzzy Logic Control Method of Traffic Signal Based on Traffic Urgency Degree

    OpenAIRE

    Yan Ge

    2014-01-01

    City intersection traffic signal control is an important method to improve the efficiency of road network and alleviate traffic congestion. This paper researches traffic signal fuzzy control method on a single intersection. A two-stage traffic signal control method based on traffic urgency degree is proposed according to two-stage fuzzy inference on single intersection. At the first stage, calculate traffic urgency degree for all red phases using traffic urgency evaluation module and select t...

  15. Modelling of urban traffic networkof signalized intersections

    OpenAIRE

    Ocran, Abena Kwantwiwaa

    2013-01-01

    This report presents how traffic network of signalized intersection in a chosen urban area called Tema is synchronized. Using a modular approach, two different types of traffic intersection commonly found in an urban area were modelled i.e. a simple intersection and a complex intersection. A direct road, even though not an intersection, was also included in the modelling because it’s commonly found in an urban area plus it connects any two intersections. Each of these scenarios was modelled u...

  16. Traffic Incident Clearance Time and Arrival Time Prediction Based on Hazard Models

    Directory of Open Access Journals (Sweden)

    Yang beibei Ji

    2014-01-01

    Full Text Available Accurate prediction of incident duration is not only important information of Traffic Incident Management System, but also an effective input for travel time prediction. In this paper, the hazard based prediction models are developed for both incident clearance time and arrival time. The data are obtained from the Queensland Department of Transport and Main Roads’ STREAMS Incident Management System (SIMS for one year ending in November 2010. The best fitting distributions are drawn for both clearance and arrival time for 3 types of incident: crash, stationary vehicle, and hazard. The results show that Gamma, Log-logistic, and Weibull are the best fit for crash, stationary vehicle, and hazard incident, respectively. The obvious impact factors are given for crash clearance time and arrival time. The quantitative influences for crash and hazard incident are presented for both clearance and arrival. The model accuracy is analyzed at the end.

  17. Three-phase theory of city traffic: Moving synchronized flow patterns in under-saturated city traffic at signals

    Science.gov (United States)

    Kerner, Boris S.

    2014-03-01

    Three-phase traffic flow theory of city traffic has been developed. Based on simulations of a stochastic microscopic traffic flow model, features of moving synchronized flow patterns (MSP) have been studied, which are responsible for a random time-delayed breakdown of a green-wave (GW) organized in a city. A possibility of GW control leading to the prevention of GW breakdown has been demonstrated. A diagram of traffic breakdown in under-saturated traffic (transition from under- to over-saturated city traffic) at the signal has been found; the diagram presents regions of the average arrival flow rate, within which traffic breakdown can occur, in dependence of parameters of the time-function of the arrival flow rate or/and signal parameters. Physical reasons for a crucial difference between results of classical theory of city traffic and three-phase theory are explained. In particular, we have found that under-saturated traffic at the signal can exist during a long time interval, when the average arrival flow rate is larger than the capacity of the classical theory; the classical capacity is equal to a minimum capacity in three-phase theory. Within a range of the average arrival flow rate between the minimum and maximum signal capacities, under-saturated traffic is in a metastable state with respect to traffic breakdown. We have distinguished the following possible causes for the metastability of under-saturated traffic: (i) The arrival flow rate during the green phase is larger than the saturation flow rate. (ii) The length of the upstream front of a queue at the signal is a finite value. (iii) The outflow rate from a MSP (the rate of MSP discharge) is larger than the saturation flow rate.

  18. Adaptive Traffic Signalization Model using Neuro-Fuzzy Controllers

    OpenAIRE

    Devesh Batra; Pragya Verma

    2014-01-01

    Current traffic lights are pre-programmed and use daily signal timing schedules, which contribute to traffic congestion and delay. Thus, with the increase in the number of vehicles on road, need for adaptive signal technology arises which has the potential to adjust the timing of red, yellow and green lights in order to accommodate changing traffic patterns and ease traffic congestion. In this paper, we present a model for adaptive traffic signalization, which uses fuzzy neura...

  19. ELMO1 signaling in apoptotic germ cell clearance and spermatogenesis.

    Science.gov (United States)

    Elliott, Michael R; Ravichandran, Kodi S

    2010-10-01

    Apoptosis and the subsequent removal of dying cells are crucial processes for tissue development and maintenance. Although we are beginning to understand the signaling pathways that control the phagocytic clearance of apoptotic cells, the physiological relevance of these pathways is lacking. During spermatogenesis, over half of the developing germ cells eventually die by apoptosis, yet the signaling pathways that regulate the phagocytic clearance of these dying cells or the impact of this clearance on development and maintenance of the germ cell population is not well understood. The ELMO1/Dock180 proteins form an evolutionarily conserved signaling module that functions as a bipartite guanine nucleotide exchange factor for the small GTPase Rac. The subsequent Rac-dependent cytoskeletal changes play an important role in the physical engulfment of apoptotic cells. Recent findings demonstrate an in vivo role for ELMO1-dependent clearance in the testes, with implications for spermatogenesis. Here we will discuss the role of apoptotic cell clearance during spermatogenesis, with a particular emphasis on ELMO1/Dock180 signaling. PMID:20958313

  20. Modelling Signal Controlled Traffic Based on Driving Behaviors

    OpenAIRE

    Yang Wang; Yanyan Chen; Ning Chen

    2015-01-01

    In urban traffic, of particular interest the traffic breakdown which is primarily resulted from the driving behaviors is emerged to respond to the traffic signal. To investigate the influences of driving behaviors on the traffic breakdown, a cellular automaton model has been developed by incorporating a number of driving behaviors typically manifesting during the different stages when the vehicle approaching a traffic light. Numerical simulations have been performed based on a road segment co...

  1. Adaptive Traffic Signalization Model using Neuro-Fuzzy Controllers

    Directory of Open Access Journals (Sweden)

    Devesh Batra*

    2014-07-01

    Full Text Available Current traffic lights are pre-programmed and use daily signal timing schedules, which contribute to traffic congestion and delay. Thus, with the increase in the number of vehicles on road, need for adaptive signal technology arises which has the potential to adjust the timing of red, yellow and green lights in order to accommodate changing traffic patterns and ease traffic congestion. In this paper, we present a model for adaptive traffic signalization, which uses fuzzy neural network for designing traffic signal controller. The controllers use vehicle detectors in order to detect the number of incoming vehicles. Based on the number of approaching vehicles, the current signal phase is either extended or terminated. The traffic volume at one particular region in an intersection is compared with that in the competing regions of the same intersection. The decision made is thus robust and results in less congestion and delays.

  2. Capacity Reliability of Signalized Intersections with Mixed Traffic Conditions

    Institute of Scientific and Technical Information of China (English)

    CHEN Xiaoming; SHAO Chunfu; LI Da; DONG Chunjiao

    2009-01-01

    The reliability of capacity of signalized intersections in mixed traffic conditions involving vehicles, bicycles, and pedestrians was investigated to complete the conventional, deterministic capacity calculations. Simulations using VISSIM provided estimates of capacity distributions, and demonstrated the effects of the analysis intervals on the distributions. With the random vehicle arrivals taken into account, a capacity reli-ability assessment method was given as a function. Assessments were also performed regarding the effects of the conflicting pedestrian and bicycle volumes on capacity reliability. The simulation indicates that the pe-destrians and bicycles result in greater random fluctuations of exclusive tuming lane capacities, but have less effect on the variability of shared lane capacities. Normal distributions can be used to model the capaci-ties for intervals not less than 10 min. At higher vehicular volumes, the capacity reliability is more sensitive to the mean and standard deviation of the pedestrian and bicycle volumes.

  3. Surface code—biophysical signals for apoptotic cell clearance

    International Nuclear Information System (INIS)

    Apoptotic cell death and the clearance of dying cells play an important and physiological role in embryonic development and normal tissue turnover. In contrast to necrosis, apoptosis proceeds in an anti-inflammatory manner. It is orchestrated by the timed release and/or exposure of so-called ‘find-me’, ‘eat me’ and ‘tolerate me’ signals. Mononuclear phagocytes are attracted by various ‘find-me’ signals, including proteins, nucleotides, and phospholipids released by the dying cell, whereas the involvement of granulocytes is prevented via ‘stay away’ signals. The exposure of anionic phospholipids like phosphatidylserine (PS) by apoptotic cells on the outer leaflet of the plasma membrane is one of the main ‘eat me’ signals. PS is recognized by a number of innate receptors as well as by soluble bridging molecules on the surface of phagocytes. Importantly, phagocytes are able to discriminate between viable and apoptotic cells both exposing PS. Due to cytoskeleton remodeling PS has a higher lateral mobility on the surfaces of apoptotic cells thereby promoting receptor clustering on the phagocyte. PS not only plays an important role in the engulfment process, but also acts as ‘tolerate me’ signal inducing the release of anti-inflammatory cytokines by phagocytes. An efficient and fast clearance of apoptotic cells is required to prevent secondary necrosis and leakage of intracellular danger signals into the surrounding tissue. Failure or prolongation of the clearance process leads to the release of intracellular antigens into the periphery provoking inflammation and development of systemic inflammatory autoimmune disease like systemic lupus erythematosus. Here we review the current findings concerning apoptosis-inducing pathways, important players of apoptotic cell recognition and clearance as well as the role of membrane remodeling in the engulfment of apoptotic cells by phagocytes. (paper)

  4. An Assessment Methodology for Emergency Vehicle Traffic Signal Priority Systems

    OpenAIRE

    McHale, Gene Michael

    2002-01-01

    Emergency vehicle traffic signal priority systems allow emergency vehicles such as fire and emergency medical vehicles to request and receive a green traffic signal indication when approaching an intersection. Such systems have been around for a number of years, however, there is little understanding of the costs and benefits of such systems once they are deployed. This research develops an improved method to assess the travel time impacts of emergency vehicle traffic signal priority system...

  5. Identification and optimization of traffic bottleneck with signal timing

    OpenAIRE

    Shaoxin Yuan; Xiangmo Zhao; Yisheng An

    2014-01-01

    In urban transportation network, traffic congestion is likely to occur at traffic bottlenecks. The signal timing at intersections together with static properties of left-turn and straight-through lanes of roads are two significant factors causing traffic bottlenecks. A discrete-time model of traffic bottleneck is hence developed to analyze these two factors, and a bottleneck indicator is introduced to estimate the comprehensive bottleneck degree of individual road in regional transportation n...

  6. Traffic breakdown at a signal: classical theory versus the three-phase theory of city traffic

    International Nuclear Information System (INIS)

    Physical reasons for a crucial difference between the results of a three-phase theory developed recently (Kerner 2011 Phys. Rev. E 84 045102(R); 2013 Europhys. Lett. 102 28010; 2014 Physica A 397 76) and the classical theory are explained. Microscopic characteristics of traffic passing a traffic signal during the green signal phase and their dependence on the duration of the green phase have been found. It turns out that a moving synchronized flow pattern (MSP), which occurs in under-saturated traffic at the signal, causes ‘compression’ of traffic flow: the rate of MSP discharge can be considerably larger than the saturation flow rate of the classical traffic theory of city traffic. This leads to a considerably larger rate of traffic passing the signal in comparison with the saturation flow rate. This effect together with traffic behavior at the upstream queue front explains the metastability of under-saturated traffic with respect to a random time-delayed traffic breakdown. (paper)

  7. Traffic breakdown at a signal: classical theory versus the three-phase theory of city traffic

    Science.gov (United States)

    Kerner, Boris S.; Klenov, Sergey L.; Schreckenberg, Michael

    2014-03-01

    Physical reasons for a crucial difference between the results of a three-phase theory developed recently (Kerner 2011 Phys. Rev. E 84 045102(R); 2013 Europhys. Lett. 102 28010; 2014 Physica A 397 76) and the classical theory are explained. Microscopic characteristics of traffic passing a traffic signal during the green signal phase and their dependence on the duration of the green phase have been found. It turns out that a moving synchronized flow pattern (MSP), which occurs in under-saturated traffic at the signal, causes ‘compression’ of traffic flow: the rate of MSP discharge can be considerably larger than the saturation flow rate of the classical traffic theory of city traffic. This leads to a considerably larger rate of traffic passing the signal in comparison with the saturation flow rate. This effect together with traffic behavior at the upstream queue front explains the metastability of under-saturated traffic with respect to a random time-delayed traffic breakdown.

  8. Traffic signals - alternative method for emissions reduction; Liikennevaloillako paeaestoet alas

    Energy Technology Data Exchange (ETDEWEB)

    Niittymaeki, J. [Helsinki Univ. of Technology, Espoo (Finland)

    2001-07-01

    Traffic signalling is a process, which adapts to the prevailing traffic. The objective of traffic signalling is to direct traffic as safely as possible through a road junction. Other objectives are to maximize the road capacity, to clarify the traffic, and to effect the selection of routs. The target of design and timing of traffic signalling is to minimize the delays of the traffic. However, traffic signalling increases the emissions and fuel consumption. Traditionally the traffic adaptive control has been arranged on the basis of the extension principle, which means the extension of the green light as long as there is demand for the signal, however, only to a set maximum time. In practice the systems seeks an adequate distance in the traffic for cutting off the green light. New methods, such as mathematical optimization, fuzzy logic, neural networks and generic algorithms have been included traffic signalling. These new methods have proven to be 10-20% more efficient than the old ones. Results of the researches have shown that it is possible to achieve significant savings in social economy, including savings in fuels consumption and environmental impacts of the traffic, by development/renovation of traffic signalling. This article reviews the studies carried out in Finland on traffic signalling. A typical driving process through a signalized road junction: deceleration, idle running, acceleration and steady driving. The emissions of these phases differ from each other. Gasoline-fueled cars equipped with catalyst produces significantly more CO during idle running than in the other phases, and the HC content is highest during deceleration. On the other hand NO{sub x} formation is highest during acceleration. Formation of CO, HC and aldehydes is lowest during steady driving, and the formation of NO{sub x} during deceleration. CO and NO{sub x} emissions of diesel engines are highest during acceleration, and HC emissions during idle running. Total emissions of diesel

  9. Study of Truck Driver Behavior at Onset of Yellow Traffic Signal Indication for the Design of Yellow Times

    OpenAIRE

    Bryant, Craig William

    2014-01-01

    Traffic signal violations by drivers are a leading contributor to crashes at signalized intersections. The yellow indication is used to inform drivers of an upcoming change in the status of the traffic signal. Yellow-interval durations are currently calculated to provide dilemma zone protection for passenger cars. Due to differences in vehicle characteristics and driver characteristics, heavy trucks such as tractor-trailers behave differently at the onset of a yellow-indication. The resea...

  10. Increasing Market Penetration of LED Traffic Signals in New York State: Review of Articles and Information on LED Traffic Signals

    OpenAIRE

    Bullough, John D; Suozzo, Margaret

    2002-01-01

    A primary purpose of this review is to identify and summarize recently published information about the use and performance of light-emitting diode (LED) traffic signals. It consists of two sections: a synopsis of experiences of municipalities using LED traffic signals in 1999 and 2000, and a discussion of technical, economic and market issues surrounding the deployment of LED signals. This review includes articles and reports published in 1999 and 2000.

  11. Integrating Traffic Signal Performance Measures into Agency Business Processes

    OpenAIRE

    Day, Christopher M.; Bullock, Darcy M; Li, Howell; Lavrenz, Steven M; Smith, W. Benjamin; Sturdevant, James R

    2016-01-01

    This report discusses uses of and requirements for performance measures in traffic signal systems facilitated by high-resolution controller event data. Uses of external travel time measurements are also discussed. The discussion is led by a high-level synthesis of the systems engineering concepts for traffic signal control, considering technical and non-technical aspects of the problem. This is followed by a presentation of the requirements for implementing data collection and processing of t...

  12. An extended signal control strategy for urban network traffic flow

    Science.gov (United States)

    Yan, Fei; Tian, Fuli; Shi, Zhongke

    2016-03-01

    Traffic flow patterns are in general repeated on a daily or weekly basis. To improve the traffic conditions by using the inherent repeatability of traffic flow, a novel signal control strategy for urban networks was developed via iterative learning control (ILC) approach. Rigorous analysis shows that the proposed learning control method can guarantee the asymptotic convergence. The impacts of the ILC-based signal control strategy on the macroscopic fundamental diagram (MFD) were analyzed by simulations on a test road network. The results show that the proposed ILC strategy can evenly distribute the accumulation in the network and improve the network mobility.

  13. Development of an Interval Management Algorithm Using Ground Speed Feedback for Delayed Traffic

    Science.gov (United States)

    Barmore, Bryan E.; Swieringa, Kurt A.; Underwood, Matthew C.; Abbott, Terence; Leonard, Robert D.

    2016-01-01

    One of the goals of NextGen is to enable frequent use of Optimized Profile Descents (OPD) for aircraft, even during periods of peak traffic demand. NASA is currently testing three new technologies that enable air traffic controllers to use speed adjustments to space aircraft during arrival and approach operations. This will allow an aircraft to remain close to their OPD. During the integration of these technologies, it was discovered that, due to a lack of accurate trajectory information for the leading aircraft, Interval Management aircraft were exhibiting poor behavior. NASA's Interval Management algorithm was modified to address the impact of inaccurate trajectory information and a series of studies were performed to assess the impact of this modification. These studies show that the modification provided some improvement when the Interval Management system lacked accurate trajectory information for the leading aircraft.

  14. Theory of self-organized traffic at light signal

    CERN Document Server

    Kerner, Boris S

    2012-01-01

    Based on numerical simulations of a three-phase traffic flow model, a probabilistic theory of traffic at the light signal is developed. We have found that very complex spatiotemporal self-organized phenomena determine features of city traffic. We have revealed that the breakdown of {\\it green wave} in a city is initiated by the emergence of a moving synchronized flow pattern (MSP) within the green wave. It turns out that a sequence of F$\\rightarrow$S$\\rightarrow$J transitions (F -- free flow, S -- synchronized flow, J -- moving queue) lead to traffic breakdown at the light signal. Both spontaneous and induced breakdowns of the green wave have been found. From a study of a variety of scenarios for arrival traffic, we have found that there are the infinite number of capacities of traffic at the light signal, which are in a capacity range between a minimum capacity and maximum capacity; each of the capacities gives a flow rate at which under-saturated traffic is in a metastable state with respect to the transiti...

  15. Theory of self-organized traffic at light signal

    OpenAIRE

    Kerner, Boris S.

    2012-01-01

    Based on numerical simulations of a three-phase traffic flow model, a probabilistic theory of traffic at the light signal is developed. We have found that very complex spatiotemporal self-organized phenomena determine features of city traffic. We have revealed that the breakdown of {\\it green wave} in a city is initiated by the emergence of a moving synchronized flow pattern (MSP) within the green wave. It turns out that a sequence of F$\\rightarrow$S$\\rightarrow$J transitions (F -- free flow,...

  16. Vehicular motion in counter traffic flow through a series of signals controlled by a phase shift

    Science.gov (United States)

    Nagatani, Takashi; Tobita, Kazuhiro

    2012-10-01

    We study the dynamical behavior of counter traffic flow through a sequence of signals (traffic lights) controlled by a phase shift. There are two lanes for the counter traffic flow: the first lane is for east-bound vehicles and the second lane is for west-bound vehicles. The green-wave strategy is studied in the counter traffic flow where the phase shift of signals in the second lane has opposite sign to that in the first lane. A nonlinear dynamic model of the vehicular motion is presented by nonlinear maps at a low density. There is a distinct difference between the traffic flow in the first lane and that in the second lane. The counter traffic flow exhibits very complex behavior on varying the cycle time, the phase difference, and the split. Also, the fundamental diagram is derived by the use of the cellular automaton (CA) model. The dependence of east-bound and west-bound vehicles on cycle time, phase difference, and density is clarified.

  17. Flight Crew Responses to the Interval Management Alternative Clearances (IMAC) Experiment

    Science.gov (United States)

    Baxley, Brian T.; Wilson, Sara R.; Swieringa, Kurt A.; Roper, Roy D.

    2016-01-01

    Interval Management Alternative Clearances (IMAC) was a human-in-the-loop simulation experiment conducted to explore the efficacy and acceptability of three IM operations: CAPTURE, CROSS, and MAINTAIN. Two weeks of data collection were conducted, with each week using twelve subject pilots and four subject controllers flying ten high-density arrival scenarios into the Denver International Airport. Overall, both the IM operations and procedures were rated very favorably by the flight crew in terms of acceptability, workload, and pilot head down time. However, several critical issues were identified requiring resolution prior to real-world implementation, including the high frequency of IM speed commands, IM speed commands requiring changes to aircraft configuration, and ambiguous IM cockpit displays that did not trigger the intended pilot reaction. The results from this experiment will be used to prepare for a flight test in 2017, and to support the development of an advanced IM concept of operations by the FAA (Federal Aviation Agency) and aviation industry.

  18. Traffic Signal Synchronization in the Saturated High-Density Grid Road Network

    OpenAIRE

    Xiaojian Hu; Jian Lu; Wei Wang,; Ye Zhirui

    2015-01-01

    Most existing traffic signal synchronization strategies do not perform well in the saturated high-density grid road network (HGRN). Traffic congestion often occurs in the saturated HGRN, and the mobility of the network is difficult to restore. In order to alleviate traffic congestion and to improve traffic efficiency in the network, the study proposes a regional traffic signal synchronization strategy, named the long green and long red (LGLR) traffic signal synchronization strategy. The essen...

  19. Emergency vehicle traffic signal preemption system

    Science.gov (United States)

    Bachelder, Aaron D. (Inventor); Foster, Conrad F. (Inventor)

    2011-01-01

    An emergency vehicle traffic light preemption system for preemption of traffic lights at an intersection to allow safe passage of emergency vehicles. The system includes a real-time status monitor of an intersection which is relayed to a control module for transmission to emergency vehicles as well as to a central dispatch office. The system also provides for audio warnings at an intersection to protect pedestrians who may not be in a position to see visual warnings or for various reasons cannot hear the approach of emergency vehicles. A transponder mounted on an emergency vehicle provides autonomous control so the vehicle operator can attend to getting to an emergency and not be concerned with the operation of the system. Activation of a priority-code (i.e. Code-3) situation provides communications with each intersection being approached by an emergency vehicle and indicates whether the intersection is preempted or if there is any conflict with other approaching emergency vehicles. On-board diagnostics handle various information including heading, speed, and acceleration sent to a control module which is transmitted to an intersection and which also simultaneously receives information regarding the status of an intersection. Real-time communications and operations software allow central and remote monitoring, logging, and command of intersections and vehicles.

  20. Acoustic Signal based Traffic Density State Estimation using SVM

    Directory of Open Access Journals (Sweden)

    Prashant Borkar

    2013-06-01

    Full Text Available Based on the information present in cumulative acoustic signal acquired from a roadside-installed single microphone, this paper considers the problem of vehicular traffic density state estimation. The occurrence and mixture weightings of traffic noise signals (Tyre, Engine, Air Turbulence, Exhaust, and Honks etc are determined by the prevalent traffic density conditions on the road segment. In this work, we extract the short-term spectral envelope features of the cumulative acoustic signals using MFCC (Mel-Frequency Cepstral Coefficients. Support Vector Machines (SVM is used as classifier is used to model the traffic density state as Low (40 Km/h and above, Medium (20-40 Km/h, and Heavy (0-20 Km/h. For the developing geographies where the traffic is non-lane driven and chaotic, other techniques (magnetic loop detectors are inapplicable. SVM classifier with different kernels are used to classify the acoustic signal segments spanning duration of 20–40 s, which results in average classification accuracy of 96.67% for Quadratic kernel function and 98.33% for polynomial kernel function, when entire frames are considered for classification.

  1. Heterogeneous cellular automata model for straight-through bicycle traffic at signalized intersection

    Science.gov (United States)

    Ren, Gang; Jiang, Hang; Chen, Jingxu; Huang, Zhengfeng; Lu, Lili

    2016-06-01

    This paper presents a cellular automata (CA) model to elucidate the straight-through movements of the heterogeneous bicycle traffic at signalized intersection. The CA model, via simulation, particularly exposits the dispersion phenomenon existing in the straight-through bicycle traffic. The nonlane-based cycling behavior and diverse bicycle properties are also incorporated in the CA model. A series of simulations are conducted to reveal the travel process, bicycles interaction and influence of the dispersion phenomenon. The simulation results show that the dispersion phenomenon significantly results in more bicycles interactions in terms of spilling maneuvers and overtaking maneuvers during the straight-through movements. Meanwhile, the dispersion phenomenon could contribute to the efficiency of the bicycle traffic, and straight-through bicycles need less time to depart the intersection under the circumstance of dispersion phenomenon. The simulation results are able to provide specific guideline for reasonably utilizing the dispersion phenomenon to improve the operational efficiency of straight-through bicycle traffic.

  2. Assessing the impact of road traffic on cycling for leisure and cycling to work

    OpenAIRE

    Wareham Nicholas J; Panter Jenna R; Foster Charlie E

    2011-01-01

    Abstract Background To explore the relationship between leisure and commuter cycling with objectively measured levels of road traffic and whether any relationship was affected by traffic levels directly outside of home or in local neighbourhood. Findings We conducted a secondary analysis of data from the UK European Prospective Investigation of Cancer (EPIC) Norfolk cohort in 2009. We used a geographical information system (GIS) and gender specific multivariate models to relate 13 927 partici...

  3. The Use of Audible Traffic Signals in the United States.

    Science.gov (United States)

    Peck, A. F.; Uslan, M.

    1990-01-01

    This paper discusses audible traffic signals (ATS) and their use by visually impaired pedestrians in the United States and other countries. Areas of concern are noted, including the types of intersections at which ATS should be installed, the locations of poles and buttons for activating the system, and the specific type of device used.…

  4. Improving bus travel times with passive traffic signal coordination

    OpenAIRE

    Estrada Romeu, Miguel Ángel; Trapote Barreira, César; Roca Riu, Mireia; Robusté Antón, Francesc

    2009-01-01

    A simulation optimization model is outlined: traffic signal offsets in intersections are calculated to minimize the travel time of bus users in an urban network. The model considers a passive signal priority system and restricts the maximal incremental delay caused to car users. The simulation tool is able to trace discrete trajectories of both buses and cars in a network. It also evaluates potential perturbations that may cause time variations for average performance. Moreover, the optimizat...

  5. Infiuence of Bicycle Traffic on Capacity of Typical Signalized Intersection

    Institute of Scientific and Technical Information of China (English)

    CHEN Xiaoming; SHAO Chunfu; YUE Hao

    2007-01-01

    Bicycle traffic has a significant effect on the capacity of signalized intersections. This paper divides the influence of bicyclists on vehicular flow into four types with the time durations estimated based on probability, shock wave, and gap acceptance theory. Vehicular saturation flow rate is predicted for various conditions on the basis of the speed-flow curve for the capacity of typical intersections influenced by bicycle traffic.The model overcomes the limitations of the Highway Capacity Manual (HCM, 2000) method for left-turns due to data collection, and takes into account the effect of trapped bicycles on the through vehicular traffic.The numerical results show that the left-turn and through capacities predicted by the model are lower than those of the HCM method. The right-turn capacity is close to that of the HCM method at Iow bicycle volumes and higher than that of the HCM method at high bicycle volumes.

  6. TRAFFIC SIGNALS MODELLING WITH LONG DISTANCE COMMUNICATIONS USING PIC MICROCONTROLLER

    Directory of Open Access Journals (Sweden)

    Ahmet ÖZEK

    2004-04-01

    Full Text Available Today, microcontrollers are widely used in control and automation systems. For the automation of traffic signalization, the crossroads need to be controlled by microcontrollers and for the automation of more than one crossroad the communication of more than one microcontroller is required. In some special cases, the intercommunication of microcontrollers is required to change crossroad status and obtain continuous flow (green weave synchronization. In this study, a method is proposed to control the traffic flow on a hospital road with two crossroads located several km. apart from each other. For the purpose of changing the crossroads status to have a continuous flow of the traffic, the series of PIC16F877 microcontroller is used.

  7. Research on Driver Behavior in Yellow Interval at Signalized Intersections

    OpenAIRE

    Zhaosheng Yang; Xiujuan Tian; Wei Wang; Xiyang Zhou; Hongmei Liang

    2014-01-01

    Vehicles are often caught in dilemma zone when they approach signalized intersections in yellow interval. The existence of dilemma zone which is significantly influenced by driver behavior seriously affects the efficiency and safety of intersections. This paper proposes the driver behavior models in yellow interval by logistic regression and fuzzy decision tree modeling, respectively, based on camera image data. Vehicle’s speed and distance to stop line are considered in logistic regression m...

  8. Traffic Congestion Evaluation and Signal Control Optimization Based on Wireless Sensor Networks: Model and Algorithms

    OpenAIRE

    Wei Zhang; Guozhen Tan; Nan Ding; Guangyuan Wang

    2012-01-01

    This paper presents the model and algorithms for traffic flow data monitoring and optimal traffic light control based on wireless sensor networks. Given the scenario that sensor nodes are sparsely deployed along the segments between signalized intersections, an analytical model is built using continuum traffic equation and develops the method to estimate traffic parameter with the scattered sensor data. Based on the traffic data and principle of traffic congestion formation, we introduce the ...

  9. Modeling Traffic Flow and Management at Un-signalized, Signalized and Roundabout Road Intersections

    OpenAIRE

    R. Kakooza; L. S.  Laboobi; J. Y.T.  Mugisha

    2005-01-01

    Traffic congestion continues to hinder economic and social development and also has a negative impact on the environment. A simple mathematical model is used to analyze the different types of road intersections in terms of their Performance in relation to managing traffic congestion and to establish the condition for stability of the road intersections after sufficiently longer periods of time (steady-state). In the analysis, single and double lane un-signalized, signalized and roundabout int...

  10. TRAFFIC SIGNALS MODELLING WITH LONG DISTANCE COMMUNICATIONS USING PIC MICROCONTROLLER

    OpenAIRE

    ÖZEK, Ahmet; Karal, Ömer

    2004-01-01

    Today, microcontrollers are widely used in control and automation systems. For the automation of traffic signalization, the crossroads need to be controlled by microcontrollers and for the automation of more than one crossroad the communication of more than one microcontroller is required. In some special cases, the intercommunication of microcontrollers is required to change crossroad status and obtain continuous flow (green weave) synchronization. In this study, a method is proposed to cont...

  11. Safety perceptions and behavior related to cycling in mixed traffic: A comparison between Brisbane and Copenhagen

    DEFF Research Database (Denmark)

    Chataway, Elijah Steven; Kaplan, Sigal; Nielsen, Thomas Alexander Sick;

    2014-01-01

    -based survey administered among cyclists in the two cities. Elicited items concerned perceived risk of infrastructure layouts, fear of traffic, cycling while distracted, use of safety gear, cycling avoidance due to feeling unsafe, and avoidance to cycle in mixed traffic conditions. The data were analyzed with...... structural equation models. Results show that, in comparison with cyclists in Copenhagen, cyclists in Brisbane perceive mixed traffic infrastructure layouts as less safe, feel more fear of traffic, and are more likely to adopt cycling avoidance as a coping strategy. Results also show that cyclists in...

  12. Modeling Traffic Flow and Management at Un-signalized, Signalized and Roundabout Road Intersections

    Directory of Open Access Journals (Sweden)

    R. Kakooza

    2005-01-01

    Full Text Available Traffic congestion continues to hinder economic and social development and also has a negative impact on the environment. A simple mathematical model is used to analyze the different types of road intersections in terms of their Performance in relation to managing traffic congestion and to establish the condition for stability of the road intersections after sufficiently longer periods of time (steady-state. In the analysis, single and double lane un-signalized, signalized and roundabout intersections are evaluated on the basis of their performance (expected number of vehicles and waiting time. Experimental scenarios are carefully designed to analyze the performance of the different types of intersections. It is noted that under light traffic, roundabout intersections perform better than un-signalized and signalized in terms of easing congestion. However under heavy traffic, signalized intersection perform better in terms of easing traffic congestion compared to un-signalized and roundabout intersections. It is further noted that for stability of a road intersection, the proportion of the time a road link stopping at an intersection is delayed should not exceed the utilization factor (the ratio of the arrival rate of vehicles to the product of number of service channels and service rate.

  13. Traffic

    International Nuclear Information System (INIS)

    This chapter deals with passenger and freight traffic, public and private transportation, traffic related environmental impacts, future developments, traffic indicators, regional traffic planning, health costs due to road traffic related air pollution, noise pollution, measures and regulations for traffic control and fuels for traffic. In particular energy consumption, energy efficiency, pollutant emissions ( CO2, SO2, NOx, HC, CO, N2O, NH3 and particulates) and environmental effects of the different types of traffic and different types of fuels are compared and studied. Legal regulations and measures for an effective traffic control are discussed. (a.n.)

  14. Research on Driver Behavior in Yellow Interval at Signalized Intersections

    Directory of Open Access Journals (Sweden)

    Zhaosheng Yang

    2014-01-01

    Full Text Available Vehicles are often caught in dilemma zone when they approach signalized intersections in yellow interval. The existence of dilemma zone which is significantly influenced by driver behavior seriously affects the efficiency and safety of intersections. This paper proposes the driver behavior models in yellow interval by logistic regression and fuzzy decision tree modeling, respectively, based on camera image data. Vehicle’s speed and distance to stop line are considered in logistic regression model, which also brings in a dummy variable to describe installation of countdown timer display. Fuzzy decision tree model is generated by FID3 algorithm whose heuristic information is fuzzy information entropy based on membership functions. This paper concludes that fuzzy decision tree is more accurate to describe driver behavior at signalized intersection than logistic regression model.

  15. Traffic Congestion Evaluation and Signal Control Optimization Based on Wireless Sensor Networks: Model and Algorithms

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2012-01-01

    Full Text Available This paper presents the model and algorithms for traffic flow data monitoring and optimal traffic light control based on wireless sensor networks. Given the scenario that sensor nodes are sparsely deployed along the segments between signalized intersections, an analytical model is built using continuum traffic equation and develops the method to estimate traffic parameter with the scattered sensor data. Based on the traffic data and principle of traffic congestion formation, we introduce the congestion factor which can be used to evaluate the real-time traffic congestion status along the segment and to predict the subcritical state of traffic jams. The result is expected to support the timing phase optimization of traffic light control for the purpose of avoiding traffic congestion before its formation. We simulate the traffic monitoring based on the Mobile Century dataset and analyze the performance of traffic light control on VISSIM platform when congestion factor is introduced into the signal timing optimization model. The simulation result shows that this method can improve the spatial-temporal resolution of traffic data monitoring and evaluate traffic congestion status with high precision. It is helpful to remarkably alleviate urban traffic congestion and decrease the average traffic delays and maximum queue length.

  16. U.S. nuclear fuel cycle regulatory issues on exclusion, exemption, and clearance

    International Nuclear Information System (INIS)

    The U.S. Nuclear Regulatory Commission is considering the use of exclusion and clearance in connection with the nuclear fuel cycle regulations. Clearance of licensed lands, buildings, structures, materials, and equipment could expose members of the public to radiation in addition to background. Establishing and implementing dose criteria for allowed concentrations of radioactivity in the various media raise challenging issues for the regulator. Clearance also raises significant regulatory issues, and these issues reflect trade-offs between concerns for protecting public health and safety, as well as other socioeconomic values and concerns. At the heart of the issues are the adequacy of risk analyses, acceptability of risks, underlying rationales, feasibility and cost of implementation, and exposures of the public to man-made radiation in relation to natural sources of radiation. (author)

  17. Fuzzy urban traffic signal control - an overview: Mehko upravljanje mestne prometne signalizacije - pregled:

    OpenAIRE

    Brodnik, Andrej; Malej, Alenka

    2007-01-01

    In the last years, there have been many attempts made to improve urban traffic signal contol systems as this is one of the most cost-effective ways to improve the traffic flow through a network intersections. Besides the traditional method for traffic signal control that are usually based on a traffic flow model, the development of new system started to consider the various emerging technologies including artifical intelligence. Application of metaheuristic methods has proven to be worth of b...

  18. Perangcangan Traffic Light Interval Waktu Dengan Sensor Sinar Infre Merah Berbasis Mikrokontroler Atmega 8535

    OpenAIRE

    Sipayung, Riman N

    2015-01-01

    Traffic light merupakan instrument elektronik, atau komponen elektronik yang dipergunakan untuk mengatur lalu lintas, Maka dari defenisi ini lah Penulis membuat traffic light sederhana menggunakan mikrokontroler ATmega 8535 sebagai pengatur lalulintas. Prinsip kerja dari traffic light mengatur kepadatan kendaraan di setiap ruas jalan dengan mengatur pengosongan kendaraan pada ruas simpang dengan menambah waktu, dengan sensor inframerah sebagai indikator kepadatan kendaraan, Pen...

  19. Synaptic membrane rafts: traffic lights for local neurotrophin signalling?

    Directory of Open Access Journals (Sweden)

    Liliana Minichiello

    2013-10-01

    Full Text Available Lipid rafts, cholesterol and lipid rich microdomains, are believed to play important roles as platforms for the partitioning of transmembrane and synaptic proteins involved in synaptic signalling, plasticity and maintenance. There is increasing evidence of a physical interaction between post-synaptic densities and post-synaptic lipid rafts. Localization of proteins within lipid rafts is highly regulated, and therefore lipid rafts may function as traffic lights modulating and fine-tuning neuronal signalling. The tyrosine kinase neurotrophin receptors (Trk and the low-affinity p75 neurotrophin receptor (p75NTR are enriched in neuronal lipid rafts together with the intermediates of downstream signalling pathways, suggesting a possible role of rafts in neurotrophin signalling. Moreover, neurotrophins and their receptors are involved in the regulation of cholesterol metabolism. Cholesterol is an important component of lipid rafts and its depletion leads to gradual loss of synapses, underscoring the importance of lipid rafts for proper neuronal function. Here, we review and discuss the idea that translocation of neurotrophin receptors in synaptic rafts may account for the selectivity of their transduced signals.

  20. Traffic signal synchronization in the saturated high-density grid road network.

    Science.gov (United States)

    Hu, Xiaojian; Lu, Jian; Wang, Wei; Zhirui, Ye

    2015-01-01

    Most existing traffic signal synchronization strategies do not perform well in the saturated high-density grid road network (HGRN). Traffic congestion often occurs in the saturated HGRN, and the mobility of the network is difficult to restore. In order to alleviate traffic congestion and to improve traffic efficiency in the network, the study proposes a regional traffic signal synchronization strategy, named the long green and long red (LGLR) traffic signal synchronization strategy. The essence of the strategy is to control the formation and dissipation of queues and to maximize the efficiency of traffic flows at signalized intersections in the saturated HGRN. With this strategy, the same signal control timing plan is used at all signalized intersections in the HGRN, and the straight phase of the control timing plan has a long green time and a long red time. Therefore, continuous traffic flows can be maintained when vehicles travel, and traffic congestion can be alleviated when vehicles stop. Using the strategy, the LGLR traffic signal synchronization model is developed, with the objective of minimizing the number of stops. Finally, the simulation is executed to analyze the performance of the model by comparing it to other models, and the superiority of the LGLR model is evident in terms of delay, number of stops, queue length, and overall performance in the saturated HGRN. PMID:25663835

  1. Diurnal and Weekly Cycles in IPv6 Traffic

    OpenAIRE

    Strowes, Stephen D.

    2016-01-01

    IPv6 activity is commonly reported as a fraction of network traffic per day. Within this traffic, however, are daily and weekly characteristics, driven by non-uniform IPv6 deployment across ISPs and regions. This paper discusses some of the more apparent patterns we observe today.

  2. Condition monitoring of valve clearance fault on a small four strokes petrol engine using vibration signals

    Directory of Open Access Journals (Sweden)

    Songpon Klinchaeam

    2010-12-01

    Full Text Available This paper studies condition monitoring technique of a small four strokes, single cylinder petrol engine using vibrationsignal analysis based on time domain, crank angle domain, and signal energy. Vibration signals are acquired from the cylinderhead of the engine and used to describe engine processes such as intake/exhaust valve operations, ignition process, andcombustion process. In this study, vibration signals have been applied to monitor various fault conditions in the engine suchas intake and exhaust valve clearance faults. Vibration signals acquired in time domain could be mapped onto crank angledomain using top dead center signal. Time domain techniques were used to analyze vibration signals so that the main eventsrelated to the engine operations could be described easily. Using energy analysis technique, all fault conditions could bealso identified. For future work, signal analysis techniques must be developed and the detected signals should be comparedwith other signals such as pressure signal in order to verify the accuracy of the results.

  3. Robust inter-beat interval estimation in cardiac vibration signals

    International Nuclear Information System (INIS)

    Reliable and accurate estimation of instantaneous frequencies of physiological rhythms, such as heart rate, is critical for many healthcare applications. Robust estimation is especially challenging when novel unobtrusive sensors are used for continuous health monitoring in uncontrolled environments, because these sensors can create significant amounts of potentially unreliable data. We propose a new flexible algorithm for the robust estimation of local (beat-to-beat) intervals from cardiac vibration signals, specifically ballistocardiograms (BCGs), recorded by an unobtrusive bed-mounted sensor. This sensor allows the measurement of motions of the body which are caused by cardiac activity. Our method requires neither a training phase nor any prior knowledge about the morphology of the heart beats in the analyzed waveforms. Instead, three short-time estimators are combined using a Bayesian approach to continuously estimate the inter-beat intervals. We have validated our method on over-night BCG recordings from 33 subjects (8 normal, 25 insomniacs). On this dataset, containing approximately one million heart beats, our method achieved a mean beat-to-beat interval error of 0.78% with a coverage of 72.69%. (paper)

  4. The Strongly Simple Cycles with Given Rotation Pairs of an Interval Map

    Institute of Scientific and Technical Information of China (English)

    Tai Xiang SUN; Hong Jian XI; Xiao Yan ZHANG

    2007-01-01

    In this paper, we introduce the notion of the strongly simple cycles with some rotation pair for interval maps and prove that, if an interval map has a cycle with given rotation pair, then it has a strongly simple cycle with the same rotation pair.

  5. Hijacking PrPC-dependent signal transduction: when prions impair Αβ clearance

    Directory of Open Access Journals (Sweden)

    Jean-Marie Launay

    2014-02-01

    Full Text Available The cellular prion protein PrPC is the normal counterpart of the scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. The recent discovery that PrPC can serve as a receptor for the amyloid Αβ peptide and relay its neurotoxicity is sparking renewed interest on this protein and its involvement in signal transduction processes. Disease-associated PrPSc shares with Αβ the ability to hijack PrPC-dependent signalling cascades, and thereby instigate pathogenic events. Among these is an impairment of Αβ clearance, uncovered in prion-infected neuronal cells. These findings add another facet to the intricate interplay between PrPC and Αβ. Here, we summarize the connection between PrP-mediated signalling and Αβ clearance and discuss its pathological implications.

  6. Signaling mechanisms involved in the acute effects of estradiol on 5-HT clearance.

    Science.gov (United States)

    Benmansour, Saloua; Privratsky, Anthony A; Adeniji, Opeyemi S; Frazer, Alan

    2014-05-01

    Estradiol was found previously to have an antidepressant-like effect and to block the ability of selective serotonin reuptake inhibitors (SSRIs) to have an antidepressant-like effect. The antidepressant-like effect of estradiol was due to estrogen receptor β (ERβ) and/or GPR30 activation, whereas estradiol's blockade of the effect of an SSRI was mediated by ERα. This study focuses on investigating signaling pathways as well as interacting receptors associated with these two effects of estradiol. In vivo chronoamperometry was used to measure serotonin transporter (SERT) function. The effect of local application of estradiol or selective agonists for ERα (PPT) or ERβ (DPN) into the CA3 region of the hippocampus of ovariectomized (OVX) rats on 5-hydroxytryptamine (5-HT) clearance as well as on the ability of fluvoxamine to slow 5-HT clearance was examined after selective blockade of signaling pathways or that of interacting receptors. Estradiol- or DPN-induced slowing of 5-HT clearance mediated by ERβ was blocked after inhibition of MAPK/ERK1/2 but not of PI3K/Akt signaling pathways. This effect also involved interactions with TrkB, and IGF-1 receptors. Estradiol's or PPT's inhibition of the fluvoxamine-induced slowing of 5-HT clearance mediated by ERα, was blocked after inhibition of either MAPK/ERK1/2 or PI3K/Akt signaling pathways. This effect involved interactions with the IGF-1 receptor and with the metabotropic glutamate receptor 1, but not with TrkB. This study illustrates some of the signaling pathways required for the effects of estradiol on SERT function, and particularly shows that ER subtypes elicit different as well as common signaling pathways for their actions. PMID:24423185

  7. Air Traffic Management Technology Demostration Phase 1 (ATD) Interval Management for Near-Term Operations Validation of Acceptability (IM-NOVA) Experiment

    Science.gov (United States)

    Kibler, Jennifer L.; Wilson, Sara R.; Hubbs, Clay E.; Smail, James W.

    2015-01-01

    The Interval Management for Near-term Operations Validation of Acceptability (IM-NOVA) experiment was conducted at the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) in support of the NASA Airspace Systems Program's Air Traffic Management Technology Demonstration-1 (ATD-1). ATD-1 is intended to showcase an integrated set of technologies that provide an efficient arrival solution for managing aircraft using Next Generation Air Transportation System (NextGen) surveillance, navigation, procedures, and automation for both airborne and ground-based systems. The goal of the IMNOVA experiment was to assess if procedures outlined by the ATD-1 Concept of Operations were acceptable to and feasible for use by flight crews in a voice communications environment when used with a minimum set of Flight Deck-based Interval Management (FIM) equipment and a prototype crew interface. To investigate an integrated arrival solution using ground-based air traffic control tools and aircraft Automatic Dependent Surveillance-Broadcast (ADS-B) tools, the LaRC FIM system and the Traffic Management Advisor with Terminal Metering and Controller Managed Spacing tools developed at the NASA Ames Research Center (ARC) were integrated into LaRC's Air Traffic Operations Laboratory (ATOL). Data were collected from 10 crews of current 757/767 pilots asked to fly a high-fidelity, fixed-based simulator during scenarios conducted within an airspace environment modeled on the Dallas-Fort Worth (DFW) Terminal Radar Approach Control area. The aircraft simulator was equipped with the Airborne Spacing for Terminal Area Routes (ASTAR) algorithm and a FIM crew interface consisting of electronic flight bags and ADS-B guidance displays. Researchers used "pseudo-pilot" stations to control 24 simulated aircraft that provided multiple air traffic flows into the DFW International Airport, and recently retired DFW air traffic controllers served as confederate Center, Feeder, Final

  8. A Proposed Model for Traffic Signal Preemption Using Global Positioning System (GPS

    Directory of Open Access Journals (Sweden)

    Nikhil Mascarenhas

    2013-07-01

    Full Text Available A Traffic Signal Preemption system is an automated system that allows normal operation of traffic lights at automated signalized intersection s to be preempted. Preemption of signals is generally done to assist emergency vehicles, such a s ambulances, so that response times are reduced and right-of-way is provided in a smooth an d controlled manner. This paper proposes an innovative and cost-effective server-centric mod el to facilitate preemption using a simple mobile phone app which uses Global Positioning Syst em (GPS and a microcontroller which controls traffic signals.

  9. Thermodynamic efficiency of the cardiac cycle and irreversibility in the interbeat interval time series

    OpenAIRE

    Alejandro Muñoz-Diosdado; Gonzalo Gálvez-Coyt; Alejandro Alonso Martínez

    2010-01-01

    Cardiac cycle can be analyzed as a thermodynamic cycle, however, the inherent variability of this cycle implies that, although in the short term the cycle is quasi-reversible, in the long term is irreversible. This work discusses two important aspects of the cardiac cycle related with thermodynamic concepts: the calculation of the cycles efficiency and the quantification of the irreversibility of interbeat interval time series. The results show that there is a variability of cardiac eff...

  10. Traffic signals analysis using qSDiff and qHDiff with surrogate data

    Science.gov (United States)

    Xu, Mengjia; Shang, Pengjian; Xia, Jianan

    2015-11-01

    Complexity in time series is an intriguing feature of living dynamical systems such as traffic systems, with potential use for identification of system state. Here, we introduce a method for complex system analysis, called generalized sample entropy and surrogate data analysis, to measure the complexity in traffic signals. The behavior of the weekday series is quite different from that of the weekend series. In addition, we propose and discuss a new method of multifractality based on multifractal detrended fluctuation analysis (MF-DFA) and surrogate data. MF-DFA is the most popular method to detect multifractal characteristics of nonstationary time series. This new method is further applied to binomial multifractal series and traffic signals of Beijing, China. Results show that multifractal characteristics of the artificial data are regular and distinguishing the traffic signals of different patterns is significant. Besides, we find that there is a connection of multifractal characteristics between binomial multifractal series and traffic signals.

  11. EVALUATION OF INCOMING TRAFFIC FLOWS STABILITY IN SIGNAL CONTROL INTELLECTUAL TECHNOLOGIES

    OpenAIRE

    Yeresov, V.; Didkovskaya, L.

    2009-01-01

    A problem of using intellectual technologies for traffic regulation through estimation of incoming traffic parameters have been considered. The parameters include the level of cycle phases saturation (xi), the coefficient of intrahour irregularity (fs), the coefficient of variation (ІN), and the criterion of stability (αgop).

  12. The RR interval spectrum, the ECG signal and aliasing

    CERN Document Server

    Gersten, A; Ronen, A; Cassuto, Y

    1999-01-01

    A reliable spectral analysis requires sampling rate at least twice as large as the frequency bound, otherwise the analysis will be unreliable and plagued with aliasing distortions. The RR samplings do not satisfy the above requirements and therefore their spectral analysis might be unreliable. In order to demonstrate the feasibility of aliasing in RR spectral analysis, we have done an experiment which have shown clearly how the aliasing was developed. In the experiments, one of us (A.G) had kept his high breathing rate constant with the aid of metronome for more than 5 minutes. The breathing rate was larger than one-half the heart rate. Very accurate results were obtained and the resulting aliasing well understood. To our best knowledge this is the first controlled experiment of this kind coducted on humans. We compared the RR spectral analysis with the spectrum of the ECG signals from which the RR intervals were extracted. In the significant for RR analysis frequencies (below one-half Hertz) significant diff...

  13. 10 CFR 431.224 - Uniform test method for the measurement of energy consumption for traffic signal modules and...

    Science.gov (United States)

    2010-01-01

    ... consumption for traffic signal modules and pedestrian modules. 431.224 Section 431.224 Energy DEPARTMENT OF... measurement of energy consumption for traffic signal modules and pedestrian modules. (a) Scope. This section... traffic signal modules and pedestrian modules. For purposes of 10 CFR part 431 and EPCA, the...

  14. Loss of Acetylcholine Signaling Reduces Cell Clearance Deficiencies in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Sérgio M Pinto

    Full Text Available The ability to eliminate undesired cells by apoptosis is a key mechanism to maintain organismal health and homeostasis. Failure to clear apoptotic cells efficiently can cause autoimmune diseases in mammals. Genetic studies in Caenorhabditis elegans have greatly helped to decipher the regulation of apoptotic cell clearance. In this study, we show that the loss of levamisole-sensitive acetylcholine receptor, but not of a typical neuronal acetylcholine receptor causes a reduction in the number of persistent cell corpses in worms suffering from an engulfment deficiency. This reduction is not caused by impaired or delayed cell death but rather by a partial restoration of the cell clearance capacity. Mutants in acetylcholine turn-over elicit a similar phenotype, implying that acetylcholine signaling is the process responsible for these observations. Surprisingly, tissue specific RNAi suggests that UNC-38, a major component of the levamisole-sensitive receptor, functions in the dying germ cell to influence engulfment efficiency. Animals with loss of acetylcholine receptor exhibit a higher fraction of cell corpses positive for the "eat-me" signal phosphatidylserine. Our results suggest that modulation by ion channels of ion flow across plasma membrane in dying cells can influence the dynamics of phosphatidylserine exposure and thus clearance efficiency.

  15. Model predictive control for hybrid vehicle ecological driving using traffic signal and road slope information

    Institute of Scientific and Technical Information of China (English)

    Kaijiang YU; Junqi YANG; Daisuke YAMAGUCHI

    2015-01-01

    This paper presents development of a control system for ecological driving of a hybrid vehicle. Prediction using traffic signal and road slope information is considered to improve the fuel economy. It is assumed that the automobile receives traffic signal information from intelligent transportation systems (ITS). Model predictive control is used to calculate optimal vehicle control inputs using traffic signal and road slope information. The performance of the proposed method was analyzed through computer simulation results. Both the fuel economy and the driving profile are optimized using the proposed approach. It was observed that fuel economy was improved compared with driving of a typical human driving model.

  16. Ergonomic investigation on pedestrian crossing with traffic light signalization.

    Science.gov (United States)

    Amado, Giuseppe; de Moraes, Anamaria

    2012-01-01

    This article is about the risk behavior adopted by pedestrians at crosswalks with traffic light equipment. It was observed that many pedestrians take risk to cross the Presidente Vargas Avenue. This avenue is located in downtown in Rio de Janeiro city, Brazil, and has a heavy vehicular traffic and intense pedestrian flow. Many pedestrians cross the four lanes of avenue dangerously disobeying the traffic light indications. To conduct this research about pedestrian's behavior at crosswalks, a model known as Communication-Human Information Processing Model - C-HIP Model was used. Investigating the stages by C-HIP model perspective, using methods and techniques for each stage, enabled to identify which factors can contribute to pedestrians to disobey traffic signs and adopt a risky behavior in pedestrian crossing. PMID:22317476

  17. Positive Switched System Approach to Traffic Signal Control for Oversaturated Intersection

    OpenAIRE

    Lin Du; Yun Zhang

    2014-01-01

    The online traffic signalization for intersection is addressed. A new model for intersection called positive switched system is presented. Then, based on the dissipativity analysis results for positive switched system, an online state-feedback control strategy for traffic signal in two-phase intersection section is proposed. A numerical example is provided to illustrate the effectiveness of our theoretical findings. Finally, in order to extend to more general cases, multiphase intersection is...

  18. GPS Tracking System Coupled With Image Processing in Traffic Signals to Enhance Life Security

    Directory of Open Access Journals (Sweden)

    Manoj Prabhakar k

    2013-08-01

    Full Text Available In modern and crowded traffic life, it becomes mandatory to save the human life by reaching the hospitalvery sooner than possible. This paper explains about the advancement in tracking the ambulance presenceamidst the traffic with the usage of GPS tracking system calculating the position of the ambulance from thetraffic signal which replaces the RF transmitter receiver circuitry. This paper also retains the use of theimage capturing technology available from the base paper (IMPACT OF IMAGE PROCESSING INSAVING THE HUMAN LIFE BY AUTOMATING TRAFFIC SIGNALS to identify the presence of theambulance, thereby changing the signalto green automatically in favour of ambulance

  19. Traffic Signals Generation with Bicolor Leds using Pic 18f Series Microcontroller.

    Directory of Open Access Journals (Sweden)

    Y.V Sripriya

    2013-10-01

    Full Text Available PIC 18F series microcontroller is used for control of signals to a specific time using port lines. In this contest we choose the Bicolor LEDs with Red and Green. The colors of the signals are illuminated by programming in the microcontroller. The aim of this paper is to generate three colors on a single traffic light instead of using three different color traffic signal lights. The purpose of this design is to reduce the manufacture cost of the signal lights and to use a minimum number of ports in a microcontroller and cable lines to transmit the signals to the light source. This paper describes a new design for the traffic signals.

  20. Symmetry breaking in optimal timing of traffic signals on an idealized two-way street

    Science.gov (United States)

    Panaggio, Mark J.; Ottino-Löffler, Bertand J.; Hu, Peiguang; Abrams, Daniel M.

    2013-09-01

    Simple physical models based on fluid mechanics have long been used to understand the flow of vehicular traffic on freeways; analytically tractable models of flow on an urban grid, however, have not been as extensively explored. In an ideal world, traffic signals would be timed such that consecutive lights turned green just as vehicles arrived, eliminating the need to stop at each block. Unfortunately, this “green-wave” scenario is generally unworkable due to frustration imposed by competing demands of traffic moving in different directions. Until now this has typically been resolved by numerical simulation and optimization. Here, we develop a theory for the flow in an idealized system consisting of a long two-way road with periodic intersections. We show that optimal signal timing can be understood analytically and that there are counterintuitive asymmetric solutions to this signal coordination problem. We further explore how these theoretical solutions degrade as traffic conditions vary and automotive density increases.

  1. Symmetry breaking in optimal timing of traffic signals on an idealized two-way street

    CERN Document Server

    Panaggio, Mark J; Hu, Peiguang; Abrams, Daniel M

    2013-01-01

    Simple physical models based on fluid mechanics have long been used to understand the flow of vehicular traffic on freeways; analytically tractable models of flow on an urban grid, however, have not been as extensively explored. In an ideal world, traffic signals would be timed such that consecutive lights turned green just as vehicles arrived, eliminating the need to stop at each block. Unfortunately, this "green wave" scenario is generally unworkable due to frustration imposed by competing demands of traffic moving in different directions. Until now this has typically been resolved by numerical simulation and optimization. Here, we develop a theory for the flow in an idealized system consisting of a long two-way road with periodic intersections. We show that optimal signal timing can be understood analytically and that there are counter-intuitive asymmetric solutions to this signal coordination problem. We further explore how these theoretical solutions degrade as traffic conditions vary and automotive dens...

  2. Pre-hospital care time intervals among victims of road traffic injuries in Iran. A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Bigdeli Maryam

    2010-07-01

    Full Text Available Abstract Background Road traffic injuries (RTIs are a major public health problem, requiring concerted efforts both for their prevention and a reduction of their consequences. Timely arrival of the Emergency Medical Service (EMS at the crash scene followed by speedy victim transportation by trained personnel may reduce the RTIs' consequences. The first 60 minutes after injury occurrence - referred to as the "golden hour"- are vital for the saving of lives. The present study was designed to estimate the average of various time intervals occurring during the pre-hospital care process and to examine the differences between these time intervals as regards RTIs on urban and interurban roads. Method A retrospective cross-sectional study was designed and various time intervals in relation to pre-hospital care of RTIs identified in the ambulance dispatch centre in Urmia, Iran from 20 March 2005 to 20 March 2007. All cases which resulted in ambulance dispatches were reviewed and those that had complete data on time intervals were analyzed. Results In total, the cases of 2027 RTI victims were analysed. Of these, 61.5 % of the subjects were injured in city areas. The mean response time for city locations was 5.0 minutes, compared with 10.6 minutes for interurban road locations. The mean on-scene time on the interurban roads was longer than on city roads (9.2 vs. 6.1 minutes, p Conclusion The response, transport and total time intervals among EMS responding to RTI incidents were longer for interurban roads, compared to the city areas. More research should take place on needs-to and access-for EMS on city and interurban roads. The notification interval seems to be a hidden part of the post-crash events and indirectly affects the "golden hour" for victim management and it needs to be measured through the establishment of the surveillance systems.

  3. Results of active cycle of breathing techniques and conventional physiotherapy in mucociliary clearance in children with cystic fibrosis

    OpenAIRE

    Hristara-Papadopoulou, A; Tsanakas, J

    2007-01-01

    Aim: The aim of the present study is the comparison of the results of the appliance of two methods of respiratory physiotherapy; the active cycle of breathing techniques in drainage positions and the conventional physiotherapy, regarding their effects on mucociliary clearance in patients with cystic fibrosis.

  4. Overcoming the Pigou-Downs Paradox Using Advanced Traffic Signal Control

    Science.gov (United States)

    Fowdur, S. C.; Rughooputh, S. D. D. V.

    2013-06-01

    Expansion of a road network has often been observed to cause more congestion and has led researchers to the formulation of traffic paradoxes such as the Pigou-Downs and the Braess paradoxes. In this paper, we present an application of advanced traffic signal control (ATSC) to overcome the Pigou-Downs paradox. Port Louis, the capital city of Mauritius is used to investigate the effect of using a harbor bridge to by-pass the city center. Using traffic cellular automata (TCA) simulations it has been shown how, if traffic is only gradually deviated along the by-pass, an overall longer travel time and decreased flux would result. By making use of ATSC, which involves traffic lights that sense the number of vehicles accumulated in the queue, better travel times and fluxes are achieved.

  5. Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.

    Science.gov (United States)

    Marat, Andrea L; Haucke, Volker

    2016-03-15

    Phosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity. Phosphatidylinositol 3-phosphates are present at the plasma membrane and within the endolysosomal system, where they serve as key regulators of both cell signalling and of intracellular membrane traffic. Here, we provide an overview of the metabolic pathways that regulate cellular synthesis of PI 3-phosphates at distinct intracellular sites and discuss the mechanisms by which these lipids regulate cell signalling and membrane traffic. Finally, we provide a framework for how PI 3-phosphate metabolism is integrated into the cellular network. PMID:26888746

  6. GPS Tracking System Coupled With Image Processing in Traffic Signals to Enhance Life Security

    OpenAIRE

    Manoj Prabhakar k; Manoj Kumar S

    2013-01-01

    In modern and crowded traffic life, it becomes mandatory to save the human life by reaching the hospitalvery sooner than possible. This paper explains about the advancement in tracking the ambulance presenceamidst the traffic with the usage of GPS tracking system calculating the position of the ambulance from thetraffic signal which replaces the RF transmitter receiver circuitry. This paper also retains the use of theimage capturing technology available from the base paper (IMPACT OF IMAGE PR...

  7. Multiobjective Traffic Signal Control Model for Intersection Based on Dynamic Turning Movements Estimation

    Directory of Open Access Journals (Sweden)

    Pengpeng Jiao

    2014-01-01

    Full Text Available The real-time traffic signal control for intersection requires dynamic turning movements as the basic input data. It is impossible to detect dynamic turning movements directly through current traffic surveillance systems, but dynamic origin-destination (O-D estimation can obtain it. However, the combined models of dynamic O-D estimation and real-time traffic signal control are rare in the literature. A framework for the multiobjective traffic signal control model for intersection based on dynamic O-D estimation (MSC-DODE is presented. A state-space model using Kalman filtering is first formulated to estimate the dynamic turning movements; then a revised sequential Kalman filtering algorithm is designed to solve the model, and the root mean square error and mean percentage error are used to evaluate the accuracy of estimated dynamic turning proportions. Furthermore, a multiobjective traffic signal control model is put forward to achieve real-time signal control parameters and evaluation indices. Finally, based on practical survey data, the evaluation indices from MSC-DODE are compared with those from Webster method. The actual and estimated turning movements are further input into MSC-DODE, respectively, and results are also compared. Case studies show that results of MSC-DODE are better than those of Webster method and are very close to unavailable actual values.

  8. Traffic Signals Control with Adaptive Fuzzy Controller in Urban Road Network

    Institute of Scientific and Technical Information of China (English)

    LI Yan; FAN Xiao-ping

    2008-01-01

    An adaptive fuzzy logic controller (AFC) is presented for the signal control of the urban traffic network.The AFC is composed of the signal control system-oriented control level and the signal controller-oriented fuzzy rules regulation level.The control level decides the signal tunings in an intersection with a fuzzy logic controller.The regulation level optimizes the fuzzy rules by the Adaptive Rule Module in AFC according to both the system performance index in current control period and the traffic flows in the last one.Consequently the system performances are improved.A weight coefficient controller (WCC) is also developed to describe the interactions of traffic flow among the adjacent intersections.So the AFC combined with the WCC can be applied in a road network for signal timings.Simulations of the AFC on a real traffic scenario have been conducted.Simulation results indicate that the adaptive controller for traffic control shows better performance than the actuated one.

  9. Traffic analysis and signal processing in optical packet switched networks

    DEFF Research Database (Denmark)

    Fjelde, Tina

    2002-01-01

    /s optical packet switched network exploiting the best of optics and electronics, is used as a thread throughout the thesis. An overview of the DAVID network architecture is given, focussing on the MAN and WAN architecture as well as the MPLS-based network hierarchy. Subsequently, the traffic performance...... into an MI. Moreover, logic XOR is demonstrated in an MZI at 10 and 20 Gbit/s with good results. Using an MI, the excellent performance of a novel scheme for MPLS label swapping exploiting logic XOR is demonstrated at 10 Gbit/s with a negligible 0.4 dB penalty. Finally, three novel schemes are described...

  10. From Cellular Attractor Selection to Adaptive Signal Control for Traffic Networks

    Science.gov (United States)

    Tian, Daxin; Zhou, Jianshan; Sheng, Zhengguo; Wang, Yunpeng; Ma, Jianming

    2016-03-01

    The management of varying traffic flows essentially depends on signal controls at intersections. However, design an optimal control that considers the dynamic nature of a traffic network and coordinates all intersections simultaneously in a centralized manner is computationally challenging. Inspired by the stable gene expressions of Escherichia coli in response to environmental changes, we explore the robustness and adaptability performance of signalized intersections by incorporating a biological mechanism in their control policies, specifically, the evolution of each intersection is induced by the dynamics governing an adaptive attractor selection in cells. We employ a mathematical model to capture such biological attractor selection and derive a generic, adaptive and distributed control algorithm which is capable of dynamically adapting signal operations for the entire dynamical traffic network. We show that the proposed scheme based on attractor selection can not only promote the balance of traffic loads on each link of the network but also allows the global network to accommodate dynamical traffic demands. Our work demonstrates the potential of bio-inspired intelligence emerging from cells and provides a deep understanding of adaptive attractor selection-based control formation that is useful to support the designs of adaptive optimization and control in other domains.

  11. Self-organization of traffic jams in cities: Effects of stochastic dynamics and signal periods

    Science.gov (United States)

    Chowdhury, Debashish; Schadschneider, Andreas

    1999-02-01

    We propose a cellular automata model for vehicular traffic in cities by combining (and appropriately modifying) ideas borrowed from the Biham-Middleton-Levine (BML) model of city traffic and the Nagel-Schreckenberg (NS) model of highway traffic. We demonstrate a phase transition from the ``free-flowing'' dynamical phase to the completely ``jammed'' phase at a vehicle density which depends on the time periods of the synchronized signals and the separation between them. The intrinsic stochasticity of the dynamics, which triggers the onset of jamming, is similar to that in the NS model, while the phenomenon of complete jamming through self-organization as well as the final jammed configurations are similar to those in the BML model. Using our model, we have made an investigation of the time dependence of the average speeds of the cars in the ``free-flowing'' phase as well as the dependence of flux and jamming on the time period of the signals.

  12. Comparison of Cardiorespiratory and Metabolic Responses in Kettlebell High-Intensity Interval Training Versus Sprint Interval Cycling.

    Science.gov (United States)

    Williams, Brian M; Kraemer, Robert R

    2015-12-01

    The purpose of this study was to determine the effectiveness of a novel exercise protocol we developed for kettlebell high-intensity interval training (KB-HIIT) by comparing the cardiorespiratory and metabolic responses to a standard sprint interval cycling (SIC) exercise protocol. Eight men volunteered for the study and completed 2 preliminary sessions, followed by two 12-minute sessions of KB-HIIT and SIC in a counterbalanced fashion. In the KB-HITT session, 3 circuits of 4 exercises were performed using a Tabata regimen. In the SIC session, three 30-second sprints were performed, with 4 minutes of recovery in between the first 2 sprints and 2.5 minutes of recovery after the last sprint. A within-subjects' design over multiple time points was used to compare oxygen consumption (V[Combining Dot Above]O2), respiratory exchange ratio (RER), tidal volume (TV), breathing frequency (f), minute ventilation (VE), caloric expenditure rate (kcal·min), and heart rate (HR) between the exercise protocols. Additionally, total caloric expenditure was compared. A significant group effect, time effect, and group × time interaction were found for V[Combining Dot Above]O2, RER, and TV, with V[Combining Dot Above]O2 being higher and TV and RER being lower in the KB-HIIT compared with the SIC. Only a significant time effect and group × time interaction were found for f, VE, kcal·min, and HR. Additionally, total caloric expenditure was found to be significantly higher during the KB-HIIT. The results of this study suggest that KB-HIIT may be more attractive and sustainable than SIC and can be effective in stimulating cardiorespiratory and metabolic responses that could improve health and aerobic performance. PMID:26360962

  13. The Combined Effect of Signal Strength and Background Traffic Load on Speech Quality in IEEE 802.11 WLAN

    Directory of Open Access Journals (Sweden)

    P. Pocta

    2011-04-01

    Full Text Available This paper deals with measurements of the combined effect of signal strength and background traffic load on speech quality in IEEE 802.11 WLAN. The ITU-T G.729AB encoding scheme is deployed in this study and the Distributed Internet Traffic Generator (D-ITG is used for the purpose of background traffic generation. The speech quality and background traffic load are assessed by means of the accomplished PESQ algorithm and Wireshark network analyzer, respectively. The results show that background traffic load has a bit higher impact on speech quality than signal strength when both effects are available together. Moreover, background traffic load also partially masks the impact of signal strength. The reasons for those findings are particularly discussed. The results also suggest some implications for designers of wireless networks providing VoIP service.

  14. Architectural design for a low cost FPGA-based traffic signal detection system in vehicles

    Science.gov (United States)

    López, Ignacio; Salvador, Rubén; Alarcón, Jaime; Moreno, Félix

    2007-05-01

    In this paper we propose an architecture for an embedded traffic signal detection system. Development of Advanced Driver Assistance Systems (ADAS) is one of the major trends of research in automotion nowadays. Examples of past and ongoing projects in the field are CHAMELEON ("Pre-Crash Application all around the vehicle" IST 1999-10108), PREVENT (Preventive and Active Safety Applications, FP6-507075, http://www.prevent-ip.org/) and AVRT in the US (Advanced Vision-Radar Threat Detection (AVRT): A Pre-Crash Detection and Active Safety System). It can be observed a major interest in systems for real-time analysis of complex driving scenarios, evaluating risk and anticipating collisions. The system will use a low cost CCD camera on the dashboard facing the road. The images will be processed by an Altera Cyclone family FPGA. The board does median and Sobel filtering of the incoming frames at PAL rate, and analyzes them for several categories of signals. The result is conveyed to the driver. The scarce resources provided by the hardware require an architecture developed for optimal use. The system will use a combination of neural networks and an adapted blackboard architecture. Several neural networks will be used in sequence for image analysis, by reconfiguring a single, generic hardware neural network in the FPGA. This generic network is optimized for speed, in order to admit several executions within the frame rate. The sequence will follow the execution cycle of the blackboard architecture. The global, blackboard architecture being developed and the hardware architecture for the generic, reconfigurable FPGA perceptron will be explained in this paper. The project is still at an early stage. However, some hardware implementation results are already available and will be offered in the paper.

  15. Driving cycles for measuring passenger car emissions on roads with traffic calming measures

    International Nuclear Information System (INIS)

    Although local authorities in the UK need to be aware of any air quality impacts resulting from their traffic calming operations, there is little information relating to the effects of different traffic calming measures. The effects on air quality on this scale are complex, and so TRL is providing guidance by developing performance indices for different measures based on their effects on vehicle emissions. The emissions indices for passenger cars are based on tests conducted on a chassis dynamometer, and this paper describes the development of the methodology for constructing the driving cycles to be used. The technique involves the measurement of the speed profiles of a large number of vehicles using a roadside LIDAR system, and the determination of typical gear selections using three-instrumented cars

  16. Driving cycles for measuring passenger car emissions on roads with traffic calming measures

    Science.gov (United States)

    Boutler; Latham; Ainge

    1999-09-01

    Although local authorities in the UK need to be aware of any air quality impacts resulting from their traffic calming operations, there is little information relating to the effects of different traffic calming measures. The effects on air quality on this scale are complex, and so TRL is providing guidance by developing performance indices for different measures based on their effects on vehicle emissions. The emissions indices for passenger cars are based on tests conducted on a chassis dynamometer, and this paper describes the development of the methodology for constructing the driving cycles to be used. The technique involves the measurement of the speed profiles of a large number of vehicles using a roadside LIDAR system, and the determination of typical gear selections using three-instrumented cars. PMID:10535109

  17. 基于交通噪声分析的交通流状态识别方法%Traffic Flow State Identification Based on Traffic Noise Signals

    Institute of Scientific and Technical Information of China (English)

    罗向龙

    2012-01-01

    A vehicle acoustic signal is composed of engine noise, tire noise, air turbulence noise and exhaust noise. Traffic noise signals mixture of multiple vehicles' acoustic signals is determined by the traffic state. Based on the analysis of the existing traffic state identification methods and vehicle sound characteristics, an identification method of the traffic flow state was proposed by using traffic noise signals. In accordance with the vehicle speed, traffic flow states were divided into the free flow, saturation flow and traffic jams. The spectrums of vehicle acoustic signals were analyzed for different traffic states, the normalized peak frequencies were as features, and different traffic flow states were recognized using support vector machine. The test results show that different traffic flow states can be correctly recognized with traffic noise signals with a high recognition accuracy.%车辆行驶时的声音主要由发动机噪声、轮胎噪声、空气涡流噪声、排气噪声组成,多个车辆构成的交通噪声取决于道路的交通流状态.在分析现有交通状态识别方法和车辆声音特性的基础上提出了一种利用交通噪声的交通状态识别方法.按照车速将交通流分为自由流、饱和流和交通拥堵3种状态,对不同交通流状态下的交通噪声信号进行谱分析,以归一化的峰值频率作为特征,用支持向量机对不同的交通流状态进行识别.试验结果表明,通过交通噪声能够正确识别不同的交通流状态,具有较高的识别精度.

  18. Traffic signal design and simulation for vulnerable road users safety and bus preemption

    International Nuclear Information System (INIS)

    Mostly, pedestrian car accidents occurred at a signalized interaction is because pedestrians cannot across the intersection safely within the green light. From the viewpoint of pedestrian, there might have two reasons. The first one is pedestrians cannot speed up to across the intersection, such as the elders. The other reason is pedestrians do not sense that the signal phase is going to change and their right-of-way is going to be lost. Developing signal logic to protect pedestrian, who is crossing an intersection is the first purpose of this study. In addition, to improve the reliability and reduce delay of public transportation service is the second purpose. Therefore, bus preemption is also considered in the designed signal logic. In this study, the traffic data of the intersection of Chong-Qing North Road and Min-Zu West Road, Taipei, Taiwan, is employed to calibrate and validate the signal logic by simulation. VISSIM 5.20, which is a microscopic traffic simulation software, is employed to simulate the signal logic. From the simulated results, the signal logic presented in this study can protect pedestrians crossing the intersection successfully. The design of bus preemption can reduce the average delay. However, the pedestrian safety and bus preemption signal will influence the average delay of cars largely. Thus, whether applying the pedestrian safety and bus preemption signal logic to an intersection or not should be evaluated carefully

  19. A Dynamic Traffic Signal Timing Model and its Algorithm for Junction of Urban Road

    DEFF Research Database (Denmark)

    Cai, Yanguang; Cai, Hao

    2012-01-01

    As an important part of Intelligent Transportation System, the scientific traffic signal timing of junction can improve the efficiency of urban transport. This paper presents a novel dynamic traffic signal timing model. According to the characteristics of the model, hybrid chaotic quantum......-time and dynamic signal control of junction. To obtain the optimal solution of the model by hybrid chaotic quantum evolutionary algorithm, the model is converted to an easily solvable form. To simplify calculation, we give the expression of the partial derivative and change rate of the objective function...... such that the implementation of the algorithm only involves function assignments and arithmetic operations and thus avoids complex operations such as integral and differential. Simulation results show that the algorithm has less remain vehicles than Webster method, higher convergence rate and...

  20. Caffeine's effect on intermittent sprint cycling performance with different rest intervals.

    Science.gov (United States)

    Lee, Chia-Lun; Cheng, Ching-Feng; Lin, Jung-Charng; Huang, Hsin-Wei

    2012-06-01

    The purpose of this study was to investigate the effects of caffeine ingestion on the performance of an intermittent sprint cycling test (ISCT) with different rest intervals. Fourteen males with team sport experience consumed 6 mg kg(-1) of caffeine or a placebo 60 min prior to completing two sets of an ISCT with 4-min rest intervals. Each set consisted of 12 × 4-s sprints with 20- or 90-s active recovery intervals at 60-70 rpm. Blood lactate was collected at baseline and immediately following the completion of six sprints in each set. At 20-s recovery intervals, peak power and total work were not significantly different between conditions during the ISCT (P > 0.05); but caffeine reduced 6.31% effort for mean power in Sprint 10 of the later stage, as well as an increased fatigue index and elevated blood lactate levels during the ISCT (P ISCT (P 0.05). In conclusion, caffeine ingestion may be ergolytic, affecting performance and fatigue development in the later stage during a prolonged and intermittent sprint test with a short recovery interval. However, caffeine produces an ergogenic effect in the initial stage of an intermittent sprint performance with a longer recovery interval. PMID:21960086

  1. Design Of Interval Type-Ii Fuzzy Logic Traffic Controller For Multilane Intersections With Emergency Vehicle Priority System Using Matlab Simulation

    Directory of Open Access Journals (Sweden)

    Mohit Jha,

    2014-06-01

    Full Text Available During the past several years fuzzy logic control has swell from one of the major active and profitable areas for research in the application of fuzzy set, especially in the zone of industrial process which do not lead themselves to control conventional methods because of lack of quantitative data regarding the input-output relations. Fuzzy control is based on fuzzy logic- a logical system which is much closer in spirit to human thinking and natural language than conventional logical systems. The fuzzy logic controller based on fuzzy logic provides a means of converting a linguistic control strategy based on expert knowledge into an automatic control strategy. As in Fuzzy logic traffic controller, the need arises for simulating and optimizing traffic control algorithms to better accommodate this increasing demand. Fuzzy optimization deals with finding the values of input parameters of a complex simulated system which result in desired output. This paper presents a MATLAB simulation of fuzzy logic traffic interval type II controller for controlling flow of traffic in multilane paths. This controller is based on the waiting time and queue length of vehicles at present green phase and vehicles queue lengths at the other lanes. The controller controls the traffic light timings and phase difference to ascertain sebaceous flow of traffic with least waiting time and queue length. In this paper, the multilane model used consists of two alleyways in each approach.

  2. Multiobjective Reinforcement Learning for Traffic Signal Control Using Vehicular Ad Hoc Network

    Science.gov (United States)

    Houli, Duan; Zhiheng, Li; Yi, Zhang

    2010-12-01

    We propose a new multiobjective control algorithm based on reinforcement learning for urban traffic signal control, named multi-RL. A multiagent structure is used to describe the traffic system. A vehicular ad hoc network is used for the data exchange among agents. A reinforcement learning algorithm is applied to predict the overall value of the optimization objective given vehicles' states. The policy which minimizes the cumulative value of the optimization objective is regarded as the optimal one. In order to make the method adaptive to various traffic conditions, we also introduce a multiobjective control scheme in which the optimization objective is selected adaptively to real-time traffic states. The optimization objectives include the vehicle stops, the average waiting time, and the maximum queue length of the next intersection. In addition, we also accommodate a priority control to the buses and the emergency vehicles through our model. The simulation results indicated that our algorithm could perform more efficiently than traditional traffic light control methods.

  3. Multiobjective Reinforcement Learning for Traffic Signal Control Using Vehicular Ad Hoc Network

    Directory of Open Access Journals (Sweden)

    Houli Duan

    2010-01-01

    Full Text Available We propose a new multiobjective control algorithm based on reinforcement learning for urban traffic signal control, named multi-RL. A multiagent structure is used to describe the traffic system. A vehicular ad hoc network is used for the data exchange among agents. A reinforcement learning algorithm is applied to predict the overall value of the optimization objective given vehicles' states. The policy which minimizes the cumulative value of the optimization objective is regarded as the optimal one. In order to make the method adaptive to various traffic conditions, we also introduce a multiobjective control scheme in which the optimization objective is selected adaptively to real-time traffic states. The optimization objectives include the vehicle stops, the average waiting time, and the maximum queue length of the next intersection. In addition, we also accommodate a priority control to the buses and the emergency vehicles through our model. The simulation results indicated that our algorithm could perform more efficiently than traditional traffic light control methods.

  4. Variation of Headways at Signalized Arterials with Respect to Distance and Cycle Times

    Directory of Open Access Journals (Sweden)

    Figen Coşkun

    2014-09-01

    Full Text Available In this study, the variation in the proportion of free vehicles at a signalized arterial is tried to be modeled with respect to distance and green/cycle time ratio. In the analysis, it is assumed that headways between vehicles can be defined with Cowan M3 distribution. From the analysis, proportion of free vehicles in the left lane of an arterial is lower than other lanes. This results indicates that, left lanes are occupied by higher vehicle volumes. The analysis also showed that, proportion free vehicles increase with respect to the distance to traffic signals as expected.

  5. No exercise-induced increase in serum BDNF after cycling near a major traffic road.

    Science.gov (United States)

    Bos, I; Jacobs, L; Nawrot, T S; de Geus, B; Torfs, R; Int Panis, L; Degraeuwe, B; Meeusen, R

    2011-08-15

    Commuting by bike has a clear health enhancing effect. Moreover, regular exercise is known to improve brain plasticity, which results in enhanced cognition and memory performance. Animal research has clearly shown that exercise upregulates brain-derived neurotrophic factor (BDNF - a neurotrophine) enhancing brain plasticity. Studies in humans found an increase in serum BDNF concentration in response to an acute exercise bout. Recently, more evidence is emerging suggesting that exposure to air pollution (such as particulate matter (PM)) is higher in commuter cyclists compared to car drivers. Furthermore, exposure to PM is linked to negative neurological effects, such as neuroinflammation and cognitive decline. We carried-out a cross-over experiment to examine the acute effect of exercise on serum BDNF, and the potential effect-modification by exposure to traffic-related air pollution. Thirty eight physically fit, non-asthmatic volunteers (mean age: 43, 26% women) performed two cycling trials, one near a major traffic road (Antwerp Ring, R1, up to 260,000 vehicles per day) and one in an air-filtered room. The air-filtered room was created by reducing fine particles as well as ultrafine particles (UFP). PM10, PM2.5 and UFP were measured. The duration (∼20min) and intensity of cycling were kept the same for each volunteer for both cycling trials. Serum BDNF concentrations were measured before and 30min after each cycling trial. Average concentrations of PM10 and PM2.5 were 64.9μg/m(3) and 24.6μg/m(3) in cycling near a major ring way, in contrast to 7.7μg/m(3) and 2.0μg/m(3) in the air-filtered room. Average concentrations of UFP were 28,180 particles/cm(3) along the road in contrast to 496 particles/cm(3) in the air-filtered room. As expected, exercise significantly increased serum BDNF concentration after cycling in the air-filtered room (+14.4%; p=0.02). In contrast, serum BDNF concentrations did not increase after cycling near the major traffic route (+0.5%; p

  6. The influence of traffic signal solutions on self-reported road-crossing behavior.

    Science.gov (United States)

    Di Stasi, Leandro L; Megías, Alberto; Cándido, Antonio; Maldonado, Antonio; Catena, Andrés

    2014-01-01

    Injury to pedestrians is a major safety hazard in many countries. Since the beginning of the last century, modern cities have been designed around the use of motor vehicles despite the unfavourable interactions between the vehicles and pedestrians. This push towards urbanization resulted in a substantial number of crashes and fatalities involving pedestrians every day, all over the world. Thus, improving the design of urban cities and townships is a pressing issue for modern society. The study presented here provides a characterization of pedestrian safety problems, with the emphasis on signalized crosswalks (i.e. traffic signal) design solutions. We tested the impact of seven different traffic light configurations (steady [green, yellow, and red], flashing [green, yellow, and red], and light off) on pedestrian self-reported road-crossing behavior, using a 11-point scale -ranging from 0 ("I never cross in this situation") to 10 ("I always cross in this situation"). Results showed that mandatory solutions (steady green vs. steady red) are the best solutions to avoid unsafe pedestrian behaviors while crossing controlled intersections (frequency of crossing: Mgreen = 9.4 ± 1 vs. Mred = 2.6 ± 2). These findings offer important guidelines for the design of future traffic signals for encouraging a pedestrian/transit-friendly environment. PMID:26055356

  7. Cell cycle and cell signal transduction in marine phytoplankton

    Institute of Scientific and Technical Information of China (English)

    LIU Jingwen; JIAO Nianzhi; CAI Huinong

    2006-01-01

    As unicellular phytoplankton, the growth of a marine phytoplankton population results directly from the completion of a cell cycle, therefore, cell-environment communication is an important way which involves signal transduction pathways to regulate cell cycle progression and contribute to growth, metabolism and primary production and respond to their surrounding environment in marine phytoplankton. Cyclin-CDK and CaM/Ca2+ are essentially key regulators in control of cell cycle and signal transduction pathway, which has important values on both basic research and applied biotechnology. This paper reviews progress made in this research field, which involves the identification and characterization of cyclins and cell signal transduction system, cell cycle control mechanisms in marine phytoplankton cells, cell cycle proteins as a marker of a terminal event to estimate the growth rate of phytoplankton at the species level, cell cycle-dependent toxin production of toxic algae and cell cycle progression regulated by environmental factors.

  8. The QT interval and cycle length: the influence of atropine, hyoscine and exercise.

    OpenAIRE

    Staniforth, D H

    1983-01-01

    Twenty-seven healthy male subjects of mean age 24.3 +/- 4.0 years and mean weight 74.9 +/- 9.1 kg took part in an investigation to assess the most suitable correction for the QT interval as a function of cardiac cycle length. 547 sets of data points were generated. Atropine 0.6, 1.2 and 1.8 mg, and hyoscine 0.4 and 0.8 mg, and exercise on a bicycle ergometer at power levels of 50-250 watts together with post-exercise values were employed to obtain a range of heart rates. Simultaneous measurem...

  9. Operating regimes of signaling cycles: statics, dynamics, and noise filtering.

    Directory of Open Access Journals (Sweden)

    Carlos Gomez-Uribe

    2007-12-01

    Full Text Available A ubiquitous building block of signaling pathways is a cycle of covalent modification (e.g., phosphorylation and dephosphorylation in MAPK cascades. Our paper explores the kind of information processing and filtering that can be accomplished by this simple biochemical circuit. Signaling cycles are particularly known for exhibiting a highly sigmoidal (ultrasensitive input-output characteristic in a certain steady-state regime. Here, we systematically study the cycle's steady-state behavior and its response to time-varying stimuli. We demonstrate that the cycle can actually operate in four different regimes, each with its specific input-output characteristics. These results are obtained using the total quasi-steady-state approximation, which is more generally valid than the typically used Michaelis-Menten approximation for enzymatic reactions. We invoke experimental data that suggest the possibility of signaling cycles operating in one of the new regimes. We then consider the cycle's dynamic behavior, which has so far been relatively neglected. We demonstrate that the intrinsic architecture of the cycles makes them act--in all four regimes--as tunable low-pass filters, filtering out high-frequency fluctuations or noise in signals and environmental cues. Moreover, the cutoff frequency can be adjusted by the cell. Numerical simulations show that our analytical results hold well even for noise of large amplitude. We suggest that noise filtering and tunability make signaling cycles versatile components of more elaborate cell-signaling pathways.

  10. The Preventive Signaling Maintenance Crew Scheduling Problem for European Railway Traffic Management system (ERTMS)

    DEFF Research Database (Denmark)

    Mohammad Pour, Shahrzad; Stidsen, Thomas Jacob Riis; Rasmussen, Kourosh Marjani

    A railway system is a large and complex infrastructure, which requires continuous maintenance in order to function correctly. Proper maintenance is critical but can also be costly. In this paper we consider the practical case of planning the preventive maintenance of railway signals in Jutland, the...... western part of Denmark. This case is particularly interesting, since the entire railway signalling system is currently being upgraded to the new European Railway Traffic Management System (ERTMS) standard. The new signals need continuous maintenance and in this article we plan the distribution of crew...... and also schedule their daily tasks. We formulate the problem as a multi depot vehicle routing problem with time windows and synchronization constraints, in a multi-day time schedule. We solve the problem for large realistic instances by introducing a constructive stage-wise algorithm. Experimental...

  11. Solving a signalized traffic intersection problem with an hyperbolic penalty function

    Science.gov (United States)

    Melo, Teófilo; Monteiro, M. Teresa T.; Matias, João

    2012-09-01

    Mathematical Program with Complementarity Constraints (MPCC) finds many applications in fields such as engineering design, economic equilibrium and mathematical programming theory itself. A queueing system model resulting from a single signalized intersection regulated by pre-timed control in traffic network is considered. The model is formulated as an MPCC problem. A MATLAB implementation based on an hyperbolic penalty function is used to solve this practical problem, computing the total average waiting time of the vehicles in all queues and the green split allocation. The problem was codified in AMPL.

  12. Diagnostics of automatic compensators of valve clearance in combustion engine with the use of vibration signal

    Science.gov (United States)

    Szymański, Grzegorz M.; Tomaszewski, Franciszek

    2016-02-01

    Dynamic development of internal combustion engines creates a need to adopt a strategy concerning operational use of these driving units based on the knowledge of their technical condition. The assessment of technical condition belongs to tasks of technical diagnostics. This article presents an analysis of issues concerning vibration diagnostics of automatic compensators of clearances in piston valves of combustion engine. Scientific experiments focused on delivering information necessary to create (and also to validate) diagnostic models enabling assessment of technical condition of those elements of combustion engine that are essential taking into account effectiveness and durability that were carried out and described here. On the basis of the worked out diagnostic model, the algorithm for assessment of the technical condition of automatic compensators of valve clearance was created.

  13. Cycle-by-Cycle Queue Length Estimation for Signalized Intersections Using Multi-Source Data

    Institute of Scientific and Technical Information of China (English)

    Zhongyu Wang; Qing Cai; Bing Wu; Yinhai Wang; Linbo Li

    2015-01-01

    In order to estimate vehicular queue length at signalized intersections accurately and overcome the shortcomings and restrictions of existing studies especially those based on shockwave theory, a new methodology is presented for estimating vehicular queue length using data from both point detectors and probe vehicles. The methodology applies the shockwave theory to model queue evolution over time and space. Using probe vehicle locations and times as well as point detector measured traffic states, analytical formulations for calculating the maximum and minimum ( residual) queue length are developed. The proposed methodology is verified using ground truth data collected from numerical experiments conducted in Shanghai, China. It is found that the methodology has a mean absolute percentage error of 17�09%, which is reasonably effective in estimating the queue length at traffic signalized intersections. Limitations of the proposed models and algorithms are also discussed in the paper.

  14. 47 CFR 73.646 - Telecommunications Service on the Vertical Blanking Interval and in the Visual Signal.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Telecommunications Service on the Vertical Blanking Interval and in the Visual Signal. 73.646 Section 73.646 Telecommunication FEDERAL COMMUNICATIONS....646 Telecommunications Service on the Vertical Blanking Interval and in the Visual Signal....

  15. Road crossing behavior under traffic light conflict: Modulating effects of green light duration and signal congruency.

    Science.gov (United States)

    Lange, Florian; Haiduk, Michael; Boos, Moritz; Tinschert, Peter; Schwarze, Anke; Eggert, Frank

    2016-10-01

    A large number of pedestrians and cyclists regularly ignore the traffic lights to cross the road illegally. In a recent analysis, illegal road crossing behavior has been shown to be enhanced in the presence of incongruent stimulus configurations. Pedestrians and cyclists are more likely to cross against a red light when exposed to an irrelevant conflicting green light. Here, we present experimental and observational data on the factors moderating the risk associated with incongruent traffic lights. In an observational study, we demonstrated that the conflict-related increase in illegal crossing rates is reduced when pedestrian and cyclist green light periods are long. In a laboratory experiment, we manipulated the color of the irrelevant signals to expose participants to different degrees of incongruency. Results revealed that individuals' performance gradually varied as a function of incongruency, suggesting that the negative impact of a conflicting green light can be reduced by slightly adjusting its color. Our findings highlight that the observation of real-world behavior at intersections and the experimental analysis of psychological processes under controlled laboratory conditions can complement each other in identifying risk factors of risky road crossing behavior. Based on this combination, our study elaborates on promising measures to improve safety at signalized intersections. PMID:27474874

  16. A Model for Capacity Considering the Interference by Pedestrian Traffic at Signal Intersections

    Institute of Scientific and Technical Information of China (English)

    Yixin Chen; Yulong He; Xiaoduan Sun

    2016-01-01

    The capacity is impacted badly by pedestrians’ violation behavior at signal intersections. In order to quantify the impact, the time⁃headway and the vehicular speed from start⁃up to reach the stable saturation flow with and without pedestrian traffic are used as the direct measurements. Using the statistical analysis, the time⁃headway of saturation flow is mainly affected by the position of pedestrians and the degree of pedestrians ’ influence is classified into four levels. Then the speed⁃time profile for the vehicular acceleration at each level is fitted by Curve Fitting Software. Based on the effect to the time⁃headway and acceleration time, the model of capacity influenced by pedestrians is established and the influence is quantified, which enriches the fundamental theory of traffic engineering. The result shows that the vehicular capacity can be decreased by 14%at the worst case ( level I ) . The conclusions obtained in this paper are valuable for better management of the signal intersection.

  17. Prediction of CO concentrations from road traffic at signalized intersections using CAL3QHC model: the Khon Kaen case study

    OpenAIRE

    Prungchan Wongwises; Pongrid Klungboonkrong; Rudklao Pan-Aram; Atit Tippichai

    2005-01-01

    Based on the US EPA air pollution model, CAL3QHC version 2.0 was applied to predict carbon monoxide (CO) concentrations from road traffic at three signalized intersections in Khon Kaen province. Four data groups required by the model, namely site parameters, traffic parameters, meteorological parameters and emission parameters were collected at each intersection and have been used as the inputs to the model. The prediction results were compared to the measurement. The results showed that the ...

  18. Pre-hospital care time intervals among victims of road traffic injuries in Iran. A cross-sectional study

    OpenAIRE

    Bigdeli Maryam; Khorasani-Zavareh Davoud; Mohammadi Reza

    2010-01-01

    Abstract Background Road traffic injuries (RTIs) are a major public health problem, requiring concerted efforts both for their prevention and a reduction of their consequences. Timely arrival of the Emergency Medical Service (EMS) at the crash scene followed by speedy victim transportation by trained personnel may reduce the RTIs' consequences. The first 60 minutes after injury occurrence - referred to as the "golden hour"- are vital for the saving of lives. The present study was designed to ...

  19. Fourier spectrum and phases for a signal in a finite interval

    Science.gov (United States)

    Belmont, Gérard; Dorville, Nicolas; Sahraoui, Fouad; Rezeau, Laurence

    2015-04-01

    When investigating the physics of turbulent media, as the solar wind or the magnetosheath plasmas, obtaining accurate Fourier spectra and phases is a crucial issue. For the different fields, the spectra allow in particular verifying whether one or several power laws can be determined in different frequency ranges. Accurate phases are necessary as well for all the "higher order statistics" studies in Fourier space, the coherence ones and for the polarization studies. Unfortunately, the Fourier analysis is not unique for a finite time interval of duration T: the frequencies lower than 1/T have a large influence on the result, which can hardly be controlled. This unknown "trend" has in particular the effect of introducing jumps at the edges of the interval, for the function under study itself, as well as for all its derivatives. The Fourier transform obtained directly by FFT (Fast Fourier Transform) is generally much influenced by these effects and cannot be used without care for wide band signals. The interference between the jumps and the signal itself provide in particular characteristic "hairs" on the spectrum, which are clearly visible on it with df≈1/T. These fluctuations are usually eliminated by smoothing the spectrum, or by averaging several successive spectra. Nevertheless, such treatments introduce uncertainties on the spectral laws (the phases being anyway completely lost). Windowing is also a method currently used to suppress or decrease the jumps, but it modifies the signal (the windowed trend has a spectrum, which is convolved with the searched one) and the phases are generally much altered. Here, we present a new data processing technique to circumvent these difficulties. It takes advantage of the fact that the signal is generally not unknown out of the interval under study: the complete signal is tapered to this interval of interest thanks to a new window function, sharp but not square. This window function is chosen such that the spectrum obtained

  20. Coordinated control model of regional traffic signals%交通区域协调控制模型

    Institute of Scientific and Technical Information of China (English)

    刘芹; 徐建闽

    2012-01-01

    为提高交通区域通行效率,构建了适合各种交通状态的区域信号协调控制模型。以区域交叉口总排队车辆数与区域总输出车辆数为性能指标,考虑上下周期排队车辆数、各交叉口闭合相位差与有效绿灯时间,建立了模型约束条件。利用粒子群算法初始化有效绿灯时间与滞留车辆数,采用模拟退火算法求解有效绿灯时间,在不同交通状态下对某交叉口路网进行了仿真。仿真结果表明:与TRANSYT模型相比,低峰时段,采用本文模型排队车辆数降低了5.3%,区域总输出车辆数增加了5.5%;高峰时段,排队车辆数降低了17.9%,区域总输出车辆数增加了33.4%。交叉口的信号方案优化结果表明:与TRANSYT模型相比,采用本文模型时,各车道饱和度均降低,平均为1.8%,最大排队车辆数平均降低2.9%。分析结果表明:本文模型在各种交通状态下都是有效的,特别是在高峰状态下,控制效果优于TRANSYT模型。%In order to improve the traffic efficiency of traffic area, a coordinated control model of regional signals was constructed under all kinds of traffic conditions. The total queue vehicle number and the total output vehicle number of regional intersection were used as performance indexes of the model. The constraint conditions of the model were established by considering the variable relationship of the adjacent cycle queue vehicle numbers, closed phase difference of intersections and effective green time. The effective green time and waiting vehicle number were initialized by particle swarm algorithm. The effective green time was solved by simulated annealing algorithm. The road network of a certain intersection was simulated under different traffic states. Simulation result shows that the queue vehicle number reduces by 5.3% and the total output vehicle number of region increases by 5.5% in low peak period compared with the TRANSYT model. The queue vehicle number reduces by

  1. Muscle oxygen changes following Sprint Interval Cycling training in elite field hockey players.

    Directory of Open Access Journals (Sweden)

    Ben Jones

    Full Text Available This study examined the effects of Sprint Interval Cycling (SIT on muscle oxygenation kinetics and performance during the 30-15 intermittent fitness test (IFT. Twenty-five women hockey players of Olympic standard were randomly selected into an experimental group (EXP and a control group (CON. The EXP group performed six additional SIT sessions over six weeks in addition to their normal training program. To explore the potential training-induced change, EXP subjects additionally completed 5 x 30s maximal intensity cycle testing before and after training. During these tests near-infrared spectroscopy (NIRS measured parameters; oxyhaemoglobin + oxymyoglobin (HbO2+ MbO2, tissue deoxyhaemoglobin + deoxymyoglobin (HHb+HMb, total tissue haemoglobin (tHb and tissue oxygenation (TSI % were taken. In the EXP group (5.34 ± 0.14 to 5.50 ± 0.14 m.s(-1 but not the CON group (pre = 5.37 ± 0.27 to 5.39 ± 0.30 m.s(-1 significant changes were seen in the 30-15 IFT performance. EXP group also displayed significant post-training increases during the sprint cycling: ΔTSI (-7.59 ± 0.91 to -12.16 ± 2.70%; ΔHHb+HMb (35.68 ± 6.67 to 69.44 ± 26.48 μM.cm; and ΔHbO2+ MbO2 (-74.29 ± 13.82 to -109.36 ± 22.61 μM.cm. No significant differences were seen in ΔtHb (-45.81 ± 15.23 to -42.93 ± 16.24. NIRS is able to detect positive peripheral muscle oxygenation changes when used during a SIT protocol which has been shown to be an effective training modality within elite athletes.

  2. Elicitation interval dependent spatiotemporal evolution of cortical spreading depression waves revealed by optical intrinsic signal imaging

    Science.gov (United States)

    Chen, Shangbin; Gong, Hui; Zeng, Shaoqun; Luo, Qingming; Li, Pengcheng

    2007-02-01

    This study aimed to investigate the variation of propagation patterns of successive cortical spreading depression (CSD) waves induced by K + or pinprick in rat cortex. In the K + induction group, 18 Sprague-Dawley rats under Î+/--chloralose/urethane anesthesia were used to elicit CSD by 1 M KCl solution in the frontal cortex. Optical intrinsic signal imaging (OISI) at an isosbestic point of hemoglobin (550 nm) was applied to examine regional cerebral blood volume (CBV) changes in the parieto-occipital cortex. In 6 of the 18 rats, OISI was performed in conjunction with DC potential recording of the cortex. The results of this group were reported previously. In the pinprick group, 6 rats were used to induce CSD by pinprick with 8 min interval, and the other 6 rats were pricked with 4 min. CBV changes during CSD appeared as repetitive propagation of wave-like hyperemia at a speed of 3.7+/-0.4 mm/min, which was characterized by a significant negative peak (-14.3+/-3.2%) in the reflectance signal. Except for the first CSD wave, the following waves don't spread fully in the observed cortex all the time and they might abort in the medial area. Independent on the stimulation of pinprick or K+, a short interval of the current CSD to the last CSD no more than 4 min would induce the current CSD be partially propagated. For the first time, the data reveals the time-varying propagation patterns of CSD waves might be affected by the interval between CSD waves. The results suggest that the propagation patterns of a series of CSD waves are time-varying in different regions of rat cortex, and the variation is related to the interval between CSD waves.

  3. An RFID-Based Intelligent Vehicle Speed Controller Using Active Traffic Signals

    Directory of Open Access Journals (Sweden)

    Joshué Pérez

    2010-06-01

    Full Text Available These days, mass-produced vehicles benefit from research on Intelligent Transportation System (ITS. One prime example of ITS is vehicle Cruise Control (CC, which allows it to maintain a pre-defined reference speed, to economize on fuel or energy consumption, to avoid speeding fines, or to focus all of the driver’s attention on the steering of the vehicle. However, achieving efficient Cruise Control is not easy in roads or urban streets where sudden changes of the speed limit can happen, due to the presence of unexpected obstacles or maintenance work, causing, in inattentive drivers, traffic accidents. In this communication we present a new Infrastructure to Vehicles (I2V communication and control system for intelligent speed control, which is based upon Radio Frequency Identification (RFID technology for identification of traffic signals on the road, and high accuracy vehicle speed measurement with a Hall effect-based sensor. A fuzzy logic controller, based on sensor fusion of the information provided by the I2V infrastructure, allows the efficient adaptation of the speed of the vehicle to the circumstances of the road. The performance of the system is checked empirically, with promising results.

  4. An RFID-Based Intelligent Vehicle Speed Controller Using Active Traffic Signals

    Science.gov (United States)

    Pérez, Joshué; Seco, Fernando; Milanés, Vicente; Jiménez, Antonio; Díaz, Julio C.; de Pedro, Teresa

    2010-01-01

    These days, mass-produced vehicles benefit from research on Intelligent Transportation System (ITS). One prime example of ITS is vehicle Cruise Control (CC), which allows it to maintain a pre-defined reference speed, to economize on fuel or energy consumption, to avoid speeding fines, or to focus all of the driver’s attention on the steering of the vehicle. However, achieving efficient Cruise Control is not easy in roads or urban streets where sudden changes of the speed limit can happen, due to the presence of unexpected obstacles or maintenance work, causing, in inattentive drivers, traffic accidents. In this communication we present a new Infrastructure to Vehicles (I2V) communication and control system for intelligent speed control, which is based upon Radio Frequency Identification (RFID) technology for identification of traffic signals on the road, and high accuracy vehicle speed measurement with a Hall effect-based sensor. A fuzzy logic controller, based on sensor fusion of the information provided by the I2V infrastructure, allows the efficient adaptation of the speed of the vehicle to the circumstances of the road. The performance of the system is checked empirically, with promising results. PMID:22219692

  5. Condition monitoring of valve clearance fault on a small four strokes petrol engine using vibration signals

    OpenAIRE

    Songpon Klinchaeam; Pornchai Nivesrangsan

    2010-01-01

    This paper studies condition monitoring technique of a small four strokes, single cylinder petrol engine using vibrationsignal analysis based on time domain, crank angle domain, and signal energy. Vibration signals are acquired from the cylinderhead of the engine and used to describe engine processes such as intake/exhaust valve operations, ignition process, andcombustion process. In this study, vibration signals have been applied to monitor various fault conditions in the engine suchas intak...

  6. 路口交通流不均衡饱和时的交通信号控制%Traffic Flow Equilibrium Saturation in Traffic Signal Control

    Institute of Scientific and Technical Information of China (English)

    李雪佳

    2012-01-01

    Aiming at the existing intersection queue, and different directions of traffic flow is not balanced, queue length sum minimum sum of traffic flow model are built, and 2 kinds of optimization of signal timing control strategy are presented by using the optimal control theory and algorithms.%针对交叉路口存在排队车辆,且不同方向上的交通流不均衡,建立排队长度总和达到最小的交通流模型,利用最优控制理论和算法给出两种优化的信号配时控制策略。

  7. Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners.

    Science.gov (United States)

    Ishiki, Manabu; Klip, Amira

    2005-12-01

    Glucose transporter (GLUT) 4 is the major glucose transporter of muscle and adipose cells, exquisitely regulated by insulin through posttranslational events. Twenty years after the seminal observations that GLUT4 levels rapidly rise at the plasma membrane (PM) and drop in endomembranes in response to an acute insulin challenge, we are still mapping the intracellular traffic of the transporter and the regulatory events that insulin unleashes. Newly synthesized GLUT4 enters an insulin-responsive compartment aided by GGA2 (an Arf-binding protein). In cultured adipocytes and myocytes, GLUT4 concentrates in a perinuclear pole through participation of microtubules and the EHD1 Eps15 homology domain-containing protein 1. In the absence of stimuli, GLUT4 distributes between recycling endosomes and the insulin-responsive compartment. A handful of proteins that bind to GLUT4 appear to regulate its half-life (e.g. Ubc9) and tethering within endomembranes (e.g. TUG). Insulin-derived signals promote not only GLUT4 mobilization toward the PM but also its traffic between endosomal compartments and internalization from the PM. Class IA phosphatidylinositol (PI) 3-kinase plays a pivotal role at several steps of GLUT4 mobilization. The PI 3-kinase --> atypical PKC and --> Akt/PKB --> AS160 signaling cascades are major regulators of GLUT4 exocytosis aided by small GTPases. At the cell periphery, GLUT4-containing vesicles tether, dock, and fuse with the PM assisted by the exocyst complex followed by engagement of a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex [with vesicle-associated membrane protein (VAMP)2 as the vesicular (v)-SNARE and soluble NSF-attachment protein (SNAP)23 and syntaxin4 as target (t)-SNAREs] regulated by the accessory proteins Munc18c, Synip and Tomosyn. Vesicle tethering and fusion are regulated by insulin through input from class IA PI 3-kinase. PMID:16150904

  8. Theoretical modeling of a gas clearance phase regulation mechanism for a pneumatically-driven split-Stirling-cycle cryocooler

    Science.gov (United States)

    Zhang, Cun-quan; Zhong, Cheng

    2015-03-01

    The concept of a new type of pneumatically-driven split-Stirling-cycle cryocooler with clearance-phase-adjustor is proposed. In this implementation, the gap between the phase-adjusting part and the cylinder of the spring chamber is used, instead of dry friction acting on the pneumatically-driven rod to control motion damping of the displacer and to adjust the phase difference between the compression piston and displacer. It has the advantages of easy damping adjustment, low cost, and simplified manufacturing and assembly. A theoretical model has been established to simulate its dynamic performance. The linear compressor is modeled under adiabatic conditions, and the displacement of the compression piston is experimentally rectified. The working characteristics of the compressor motor and the principal losses of cooling, including regenerator inefficiency loss, solid conduction loss, shuttle loss, pump loss and radiation loss, are taken into account. The displacer motion was modeled as a single-degree-of-freedom (SDOF) forced system. A set of governing equations can be solved numerically to simulate the cooler's performance. The simulation is useful for understanding the physical processes occurring in the cooler and for predicting the cooler's performance.

  9. Expression of suppressor of cytokine signaling 1 (SOCS1 impairs viral clearance and exacerbates lung injury during influenza infection.

    Directory of Open Access Journals (Sweden)

    Keer Sun

    2014-12-01

    Full Text Available Suppressor of cytokine signaling (SOCS proteins are inducible feedback inhibitors of cytokine signaling. SOCS1-/- mice die within three weeks postnatally due to IFN-γ-induced hyperinflammation. Since it is well established that IFN-γ is dispensable for protection against influenza infection, we generated SOCS1-/-IFN-γ-/- mice to determine whether SOCS1 regulates antiviral immunity in vivo. Here we show that SOCS1-/-IFN-γ-/- mice exhibited significantly enhanced resistance to influenza infection, as evidenced by improved viral clearance, attenuated acute lung damage, and consequently increased survival rates compared to either IFN-γ-/- or WT animals. Enhanced viral clearance in SOCS1-/-IFN-γ-/- mice coincided with a rapid onset of adaptive immune responses during acute infection, while their reduced lung injury was associated with decreased inflammatory cell infiltration at the resolution phase of infection. We further determined the contribution of SOCS1-deficient T cells to antiviral immunity. Anti-CD4 antibody treatment of SOCS1-/-IFN-γ-/- mice had no significant effect on their enhanced resistance to influenza infection, while CD8+ splenocytes from SOCS1-/-IFN-γ-/- mice were sufficient to rescue RAG1-/- animals from an otherwise lethal infection. Surprisingly, despite their markedly reduced viral burdens, RAG1-/- mice reconstituted with SOCS1-/-IFN-γ-/- adaptive immune cells failed to ameliorate influenza-induced lung injury. In conclusion, in the absence of IFN-γ, the cytoplasmic protein SOCS1 not only inhibits adaptive antiviral immune responses but also exacerbates inflammatory lung damage. Importantly, these detrimental effects of SOCS1 are conveyed through discrete cell populations. Specifically, while SOCS1 expression in adaptive immune cells is sufficient to inhibit antiviral immunity, SOCS1 in innate/stromal cells is responsible for aggravated lung injury.

  10. TRAFFIC RETIMING SYSTEM USING IMAGE PROCESSING

    Directory of Open Access Journals (Sweden)

    Tanmayi Jain*

    2015-07-01

    Full Text Available One of the main problems in cities is traffic, this paper proposed new solution to traffic control. The main design concept of this project is to control the traffic automatically. System is made more efficient with addition of intelligence in term of artificial vision, using image processing techniques to estimate actual road traffic and compute time, each time for every road before enabling the signal. This model is resemblance of traditional traffic police man who takes better decision every time and soothes traffic flow. Unpredicted growth of traffic today has created serious problem in metro cities. This project has been implemented in the Matlab software and it aims to prevent heavy traffic in highways. Moreover, for implementing this project following steps must be considered: 1 image acquisition 2 RGB to gray scale transformation 3 image cropping and 4 density estimation. At first, film of highway is captured by a camera which is installed at the square that is intersection of road. Then, the camera takes pictures at regular intervals and then the captured frame is sent to the computer for further processing. After that, the number of cars in square is specified. At the end, if the number of cars is more than a threshold, a message is shown to inform the traffic status. By this message we can predict the need to reduce the size of traffic carried. Experiments show that the algorithm will work properly and also we can re-time the traffic green light and maintain the proper traffic management. Most of the city traffic is controlled by sensors and cameras shall be installed in big highways and streets. But existence of a system for detecting the size of traffic automatically will be felt. Such systems can allow extracting information from the bigger traffic issue and helps us decide to improve the traffic policy. The project aims to render automate control system for traffic on highways and street.

  11. Tunable Signal Processing through a Kinase Control Cycle: the IKK Signaling Node

    Science.gov (United States)

    Behar, Marcelo; Hoffmann, Alexander

    2013-01-01

    The transcription factor NFκB, a key component of the immune system, shows intricate stimulus-specific temporal dynamics. Those dynamics are thought to play a role in controlling the physiological response to cytokines and pathogens. Biochemical evidence suggests that the NFκB inducing kinase, IKK, a signaling hub onto which many signaling pathways converge, is regulated via a regulatory cycle comprising a poised, an active, and an inactive state. We hypothesize that it operates as a modulator of signal dynamics, actively reshaping the signals generated at the receptor proximal level. Here we show that a regulatory cycle can function in at least three dynamical regimes, tunable by regulating a single kinetic parameter. In particular, the simplest three-state regulatory cycle can generate signals with two well-defined phases, each with distinct coding capabilities in terms of the information they can carry about the stimulus. We also demonstrate that such a kinase cycle can function as a signal categorizer classifying diverse incoming signals into outputs with a limited set of temporal activity profiles. Finally, we discuss the extension of the results to other regulatory motifs that could be understood in terms of the regimes of the three-state cycle. PMID:23823243

  12. Resistance exercise-induced S6K1 kinase activity is not inhibited in human skeletal muscle despite prior activation of AMPK by high-intensity interval cycling

    DEFF Research Database (Denmark)

    Apró, William; Moberg, Marcus; Hamilton, D. Lee;

    2015-01-01

    hypothesis was tested in eight trained male subjects who in randomized order performed either resistance exercise only (R) or interval cycling followed by resistance exercise (ER). Biopsies taken from the vastus lateralis before and after endurance exercise and repeatedly after resistance exercise were......Combining endurance and strength training in the same session has been reported to reduce the anabolic response to the latter form of exercise. The underlying mechanism, based primarily on results from rodent muscle, is proposed to involve AMPK-dependent inhibition of mTORC1 signaling. This...

  13. Signals for the lysosome: a control center for cellular clearance and energy metabolism

    OpenAIRE

    Settembre, Carmine; Fraldi, Alessandro; Medina, Diego L.; Ballabio, Andrea

    2013-01-01

    For a long time lysosomes were considered merely to be cellular “incinerators” involved in the degradation and recycling of cellular waste. However, there is now compelling evidence indicating that lysosomes have a much broader function and that they are involved in fundamental processes such as secretion, plasma membrane repair, signaling and energy metabolism. Furthermore, the essential role of lysosomes in the autophagic pathway puts these organelles at the crossroads of several cellular p...

  14. Generating clock signals for a cycle accurate, cycle reproducible FPGA based hardware accelerator

    Science.gov (United States)

    Asaad, Sameth W.; Kapur, Mohit

    2016-01-05

    A method, system and computer program product are disclosed for generating clock signals for a cycle accurate FPGA based hardware accelerator used to simulate operations of a device-under-test (DUT). In one embodiment, the DUT includes multiple device clocks generating multiple device clock signals at multiple frequencies and at a defined frequency ratio; and the FPG hardware accelerator includes multiple accelerator clocks generating multiple accelerator clock signals to operate the FPGA hardware accelerator to simulate the operations of the DUT. In one embodiment, operations of the DUT are mapped to the FPGA hardware accelerator, and the accelerator clock signals are generated at multiple frequencies and at the defined frequency ratio of the frequencies of the multiple device clocks, to maintain cycle accuracy between the DUT and the FPGA hardware accelerator. In an embodiment, the FPGA hardware accelerator may be used to control the frequencies of the multiple device clocks.

  15. Game Theory Model of Traffic Participants within Amber Time at Signalized Intersection

    OpenAIRE

    2014-01-01

    The traffic light scheme is composed of red, green, and amber lights, and it has been defined clearly for the traffic access of red and green lights; however, the definition of that for the amber light is indistinct, which leads to the appearance of uncertainty factors and serious traffic conflicts during the amber light. At present, the traffic administrations are faced with the decision of whether to forbid passing or not during the amber light in the cities of China. On one hand, it will g...

  16. Integrin α PAT-2/CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Hsiao-Han Hsieh

    Full Text Available Clearance of apoptotic cells by engulfment plays an important role in the homeostasis and development of multicellular organisms. Despite the fact that the recognition of apoptotic cells by engulfment receptors is critical in inducing the engulfment process, the molecular mechanisms are still poorly understood. Here, we characterize a novel cell corpse engulfment pathway mediated by the integrin α subunit PAT-2 in Caenorhabditis elegans and show that it specifically functions in muscle-mediated engulfment during embryogenesis. Inactivation of pat-2 results in a defect in apoptotic cell internalization. The PAT-2 extracellular region binds to the surface of apoptotic cells in vivo, and the intracellular region may mediate signaling for engulfment. We identify essential roles of small GTPase CDC-42 and its activator UIG-1, a guanine-nucleotide exchange factor, in PAT-2-mediated cell corpse removal. PAT-2 and CDC-42 both function in muscle cells for apoptotic cell removal and are co-localized in growing muscle pseudopods around apoptotic cells. Our data suggest that PAT-2 functions through UIG-1 for CDC-42 activation, which in turn leads to cytoskeletal rearrangement and apoptotic cell internalization by muscle cells. Moreover, in contrast to PAT-2, the other integrin α subunit INA-1 and the engulfment receptor CED-1, which signal through the conserved signaling molecules CED-5 (DOCK180/CED-12 (ELMO or CED-6 (GULP respectively, preferentially act in epithelial cells to mediate cell corpse removal during mid-embryogenesis. Our results show that different engulfing cells utilize distinct repertoires of receptors for engulfment at the whole organism level.

  17. Game Theory Model of Traffic Participants within Amber Time at Signalized Intersection

    Directory of Open Access Journals (Sweden)

    Weiwei Qi

    2014-01-01

    Full Text Available The traffic light scheme is composed of red, green, and amber lights, and it has been defined clearly for the traffic access of red and green lights; however, the definition of that for the amber light is indistinct, which leads to the appearance of uncertainty factors and serious traffic conflicts during the amber light. At present, the traffic administrations are faced with the decision of whether to forbid passing or not during the amber light in the cities of China. On one hand, it will go against the purpose of setting amber lights if forbidding passing; on the other hand, it may lead to a mess of traffic flow running if not. And meanwhile the drivers are faced with the decision of passing the intersection or stopping during the amber light as well. So the decision-making behavior of traffic administrations and drivers can be converted into a double game model. And through quantification of their earnings in different choice conditions, the optimum decision-making plan under specific conditions could be solved via the Nash equilibrium solution concept. Thus the results will provide a basis for the formulation of the traffic management strategy.

  18. Game theory model of traffic participants within amber time at signalized intersection.

    Science.gov (United States)

    Qi, Weiwei; Wen, Huiying; Fu, Chuanyun; Song, Mo

    2014-01-01

    The traffic light scheme is composed of red, green, and amber lights, and it has been defined clearly for the traffic access of red and green lights; however, the definition of that for the amber light is indistinct, which leads to the appearance of uncertainty factors and serious traffic conflicts during the amber light. At present, the traffic administrations are faced with the decision of whether to forbid passing or not during the amber light in the cities of China. On one hand, it will go against the purpose of setting amber lights if forbidding passing; on the other hand, it may lead to a mess of traffic flow running if not. And meanwhile the drivers are faced with the decision of passing the intersection or stopping during the amber light as well. So the decision-making behavior of traffic administrations and drivers can be converted into a double game model. And through quantification of their earnings in different choice conditions, the optimum decision-making plan under specific conditions could be solved via the Nash equilibrium solution concept. Thus the results will provide a basis for the formulation of the traffic management strategy. PMID:25580108

  19. Dependence of 'CT clearance' on dosage and time. Die Dosis- und Zeitabhaengigkeit der 'CT-Clearance'

    Energy Technology Data Exchange (ETDEWEB)

    Kaltenborn, H.A.; Klose, K.J.; Dexheimer, C. (Mainz Univ. (Germany, F.R.). Inst. fuer Klinische Strahlenkunde); Steinijans, V. (Byk Gulden, Konstanz (Germany, F.R.). Abt. fuer Biometrie)

    1989-06-01

    The contrast medium dose used in CT renal function analysis corresponds to about 1 ml/kg body weight at a measurement interval of 5 or 10 minutes. In the present study the dependence of 'CT clearance' on dosage and time was examined in 12 healthy subjects. The amount of clearance was directly proportional to the employed contrast medium dose and to the length of the measurement interval. On account of the superior signal-to-noise ratio, the higher dose (1 ml/kg body weight) will continue to be prefered in future. The measurement interval can be limited to 10 minutes. (orig.).

  20. The Impact of a Signalized Crosswalk on Traffic Speed and Street-Crossing Behaviors of Residents in an Underserved Neighborhood.

    Science.gov (United States)

    Schultz, Courtney L; Sayers, Stephen P; Wilhelm Stanis, Sonja A; Thombs, Lori A; Thomas, Ian M; Canfield, Shannon M

    2015-10-01

    Infrastructure improvements such as pedestrian crosswalks that calm traffic and increase access to physical activity opportunities could alleviate important barriers to active living in underserved communities with outdated built environments. The purpose of this study was to explore how the built environment influences street-crossing behaviors and traffic speeds in a low-income neighborhood with barriers to active living in Columbia, Missouri. In 2013, a signalized pedestrian crosswalk and 400-ft-long median was constructed along a busy 5-lane, high-speed arterial highway linking low-income housing with a park and downtown areas. Data collection occurred prior to June 2012, and after June 2013, completion of the project at the intervention site and control site. Direct observation of street-crossing behaviors was performed at designated intersections/crosswalks or non-designated crossing points. Traffic volume and speed were captured using embedded magnetic traffic detectors. At the intervention site, designated crossings increased at the new crosswalk (p < 0.001), but not at non-designated crossings (p = 0.52) or designated crossings at intersections (p = 0.41). At the control site, there was no change in designated crossings (p = 0.94) or non-designated crossings (p = 0.79). Motor vehicles traveling above the speed limit of 35 mph decreased from 62,056 (46 %) to 46,256 (35 %) (p < 0.001) at the intervention site and increased from 57,891 (49 %) to 65,725 (59 %) (p < 0.001) at the control site. The installation of a signalized crosswalk facilitated an increase in safe street crossings and calmed traffic volume and speed in an underserved neighborhood. We believe these findings have significant public health implications that could be critical to advocacy efforts to improve infrastructure projects in similar communities. PMID:26354602

  1. NUMB is a break of WNT-Notch signaling cycle.

    Science.gov (United States)

    Katoh, Masuko; Katoh, Masaru

    2006-09-01

    Notch, FGF and WNT signaling pathways cross-talk during embryogenesis, tissue regeneration and carcinogenesis. Notch-ligand binding to Notch receptors leads to the cleavage of Notch receptors and the following nuclear translocation of Notch intracellular domain (NICD) to induce transcriptional activation of Notch target genes. Notch signaling inhibitors, NUMB and NUMB-like (NUMBL), are docking proteins with PTB domain. We searched for the TCF/LEF-binding site within the promoter region of NUMB and NUMBL genes. Because two TCF/LEF-binding sites were identified within human NUMB promoter based on bioinformatics and human intelligence (Humint), comparative integromics analyses on NUMB orthologs were further performed. Chimpanzee NUBM gene, consisting of 13 exons, was identified within NW_115880.1 genome sequence. XM_510045.1 was not the correct coding sequence for chimpanzee NUMB. Chimpanzee NUMB gene was found to encode a 651-amino-acid protein showing 99.5, 93.9 and 82.6% total-amino-acid identity with human NUMB, mouse Numb and chicken numb, respectively. Human NUMB mRNA was expressed in placenta, ES cells, neural tissues, trachea, testis, uterus, thymus, coronary artery as well as in a variety of tumors, such as cervical cancer, tong tumor, brain tumor, colorectal and breast cancer. Although distal TCF/LEF-binding site within human NUMB promoter was conserved only among primate NUMB orthologs, proximal TCF/LEF-binding site was conserved among primate and rodent NUMB orthologs. NUMB, JAG1, FGF18, FGF20 and SPRY4 are potent targets of the canonical WNT signaling pathway in progenitor cells. NUMB inhibits Notch signaling in progenitor cells to induce differentiation, while JAG1 activates Notch signaling in stem cells to maintain self-renewal potential. Because Notch signaling inhibitor NUMB was identified as the safe apparatus for the WNT - Notch signaling cycle, epigenetic silencing, deletion and loss-of-function mutation of NUMB gene could lead to carcinogenesis

  2. Delay Estimates of Mixed Traffic Flow at Signalized Intersections in China

    Institute of Scientific and Technical Information of China (English)

    SU Yuelong; WEI Zheng; CHENG Sihan; YAO Danya; ZHANG Yi; LI Li

    2009-01-01

    Two characteristics of Chinese mixed traffic invalidate the conventional queuing delay estimates for western countries. First, the driving characteristics of Chinese drivers lead to different delays even though the other conditions are the same. Second, urban traffic flow in China is often hindered by pedestrians at intersections, such that imported intelligent traffic control systems do not work appropriately. Typical delay estimates for Chinese conditions were obtained from data for over 500 vehicle queues in Beijing collected using charge coupled device (CCD) cameras. The results show that the delays mainly depend on the pro-portion and positions of heavy vehicles in the queue, as well as the start-up situations (with or without inter-ference). A simplified delay estimation model considers vehicle types and positions that compares well with the observed traffic delays.

  3. Self-organized control of traffic signals based on reinforcement learning and genetic algorithm%基于再励学习和遗传算法的交通信号自组织控制

    Institute of Scientific and Technical Information of China (English)

    欧海涛; 杨煜普; 张文渊; 许晓鸣

    2000-01-01

    提出一种将再励学习与遗传算法相结合的遗传再励学习方法对交通信号进行自组织控制再励学习是针对每一个道路交叉口交通流的优化,修正每个信号灯周期的绿性比;而遗传算法产生局部学习过程的全局优化标准,即是修正信号灯周期的大小这种方法克服了现有的控制方法需要大量数据传输通讯、准确的交通模型等缺陷,将局部优化和全局优化统一起来通过计算机仿真实验表明了方法的有效性%A combination algorithm of reinforcement learning and genetic algorithm is proposed in this paper to self-organized control of the traffic signals.Reinforcement learning focuses on the optimization of an intersection traffic flow which modified the split of traffic signal cycle,while the genetic algorithm are intended to introduce a global optimization criterion to each of the local learning processes which modified the cycle itself of traffic signals.This method overcome the drawbacks in existing control methods such as huge data transfer and communication,accurately traffic model and so on,and unified the local optimization and global optimization.Through the computer simulation,the effectiveness of method is demonstated.

  4. Effect of background region of interest and time-interval selection on glomerular filtration ratio estimation by percentage dose uptake of (99m)Tc-DTPA in comparison with (51)Cr-EDTA clearance in healthy cats.

    Science.gov (United States)

    Debruyn, Katrien; Vandermeulen, Eva; Saunders, Jimmy H; Dobbeleir, André A; Ham, Hamphrey R; Peremans, Kathelijne

    2013-08-01

    Evaluation of glomerular function is a useful part of the diagnostic approach in animals suspected of having renal disease. Time-interval and background region of interest (bg ROI) selection are determining factors when calculating the glomerular filtration ratio (GFR) based on percentage uptake of (99m)technetium-labelled diethylene triamine penta-acetic acid ((99m)Tc-DTPA). Therefore, three different time intervals (60-120 s, 120-180 s, 60-180 s) and three different bg ROIs (C-shape, caudolateral, cranial + caudal) were investigated. In addition, global GFRs based on percentage dose uptake of (99m)Tc-DTPA for the different time-intervals and bg ROIs were compared with the global GFR based on (51)chromium-ethylene diaminic tetra-acetic acid ((51)Cr-EDTA) plasma clearance in nine healthy European domestic shorthair cats. Paired Student's t-tests and linear regression analysis were used to analyse the data. Different time intervals seemed to cause significant variation (P <0.01) in absolute GFR values, regardless of the choice of bg ROI. Significant differences (P <0.01) between bg ROIs were only observed in the 120-180s time interval between the C-shape and cranial + caudal bg ROI, and between the caudolateral and cranial + caudal bg ROI. The caudolateral bg ROI in the 60-180 s time interval showed the highest correlation coefficient (r = 0.882) between (99m)Tc-DTPA and (51)Cr-EDTA, although a significant difference (P <0.05) was present between both techniques. PMID:23349527

  5. Life cycle cost optimization of biofuel supply chains under uncertainties based on interval linear programming

    DEFF Research Database (Denmark)

    Ren, Jingzheng; Dong, Liang; Sun, Lu;

    2015-01-01

    The aim of this work was to develop a model for optimizing the life cycle cost of biofuel supply chain under uncertainties. Multiple agriculture zones, multiple transportation modes for the transport of grain and biofuel, multiple biofuel plants, and multiple market centers were considered in this...

  6. Mucociliary clearance

    DEFF Research Database (Denmark)

    Munkholm, Mathias; Mortensen, Jann

    2014-01-01

    Mucociliary clearance has long been known to be a significant innate defence mechanism against inhaled microbes and irritants. Important knowledge has been gathered regarding the anatomy and physiology of this system, and in recent years, extensive studies of the pathophysiology related to lung...... diseases characterized by defective mucus clearance have resulted in a variety of therapies, which might be able to enhance clearance from the lungs. In addition, ways to study in vivo mucociliary clearance in humans have been developed. This can be used as a means to assess the effect of different...... pharmacological interventions on clearance rate, to study the importance of defective mucus clearance in different lung diseases or as a diagnostic tool in the work-up of patients with recurrent airway diseases. The aim of this review is to provide an overview of the anatomy, physiology, pathophysiology, and...

  7. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    OpenAIRE

    Arking, Dan E; Sara L. Pulit; Crotti, Lia; van der Harst, Pim; Munroe, Patricia B; Koopmann, Tamara T.; Sotoodehnia, Nona; Rossin, Elizabeth J.; Morley, Michael; Wang, Xinchen; Johnson, Andrew D.; Lundby, Alicia; Gudbjartsson, Daníel F.; Noseworthy, Peter A.; Eijgelsheim, Mark

    2014-01-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal Mendelian Long QT Syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals we identified 35 common variant QT interval loci, that collectively explain ∼8-10% of QT variation and highlight the imp...

  8. Green Wave Traffic Optimization - A Survey

    DEFF Research Database (Denmark)

    Warberg, Andreas; Larsen, Jesper; Jørgensen, Rene Munk

    important conflicts, which support the notion that traffic signal optimization is a multi-objective problem, and relates this to the most common measures of effectiveness. A distinction can be made between classical systems, which operate with a common cycle time, and the more flexible, phase......-based, approach, which is shown to be more suitable for adaptive traffic control. To support this claim three adaptive systems, which use alternatives to the classical optimization procedures, are described in detail....

  9. Signals of new physics in global event properties in pp collisions in the TeV energy domain: rapidity intervals

    CERN Document Server

    Giovannini, Alberto

    2003-01-01

    The study of possible new physics signals in global event properties in pp collisions in the TeV energy domain is extended from full phase-space to rapidity intervals experimentally accessible at LHC. The elbow structure in the total multiplicity distribution predicted in full phase-space is clearly present also in restricted rapidity intervals, leading to very strong charged particle correlations. It is also found that energy densities comparable to those reached in heavy ion collisions at RHIC could be attained in pp collisions at LHC.

  10. A Life-Cycle Cost Estimating Methodology for NASA-Developed Air Traffic Control Decision Support Tools

    Science.gov (United States)

    Wang, Jianzhong Jay; Datta, Koushik; Landis, Michael R. (Technical Monitor)

    2002-01-01

    This paper describes the development of a life-cycle cost (LCC) estimating methodology for air traffic control Decision Support Tools (DSTs) under development by the National Aeronautics and Space Administration (NASA), using a combination of parametric, analogy, and expert opinion methods. There is no one standard methodology and technique that is used by NASA or by the Federal Aviation Administration (FAA) for LCC estimation of prospective Decision Support Tools. Some of the frequently used methodologies include bottom-up, analogy, top-down, parametric, expert judgement, and Parkinson's Law. The developed LCC estimating methodology can be visualized as a three-dimensional matrix where the three axes represent coverage, estimation, and timing. This paper focuses on the three characteristics of this methodology that correspond to the three axes.

  11. Traffic sounds and cycling safety : the use of electronic devices by cyclists and the quietness of hybrid and electric cars.

    NARCIS (Netherlands)

    Stelling-Konczak, A. Hagenzieker, M.P. & Wee, B. van

    2015-01-01

    The growing popularity of electric devices and the increasing number of hybrid and electric cars have recently raised concerns about the use of auditory signals by vulnerable road users. This paper consolidates current knowledge about the two trends in relation to cycling safety. Both a literature r

  12. Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.

    Directory of Open Access Journals (Sweden)

    Kathryn A Radigan

    Full Text Available During the recent H1N1 outbreak, obese patients had worsened lung injury and increased mortality. We used a murine model of influenza A pneumonia to test the hypothesis that leptin receptor deficiency might explain the enhanced mortality in obese patients.We infected wild-type, obese mice globally deficient in the leptin receptor (db/db and non-obese mice with tissue specific deletion of the leptin receptor in the lung epithelium (SPC-Cre/LepR fl/fl or macrophages and alveolar type II cells (LysM-Cre/Lepr fl/fl with influenza A virus (A/WSN/33 [H1N1] (500 and 1500 pfu/mouse and measured mortality, viral clearance and several markers of lung injury severity.The clearance of influenza A virus from the lungs of mice was impaired in obese mice globally deficient in the leptin receptor (db/db compared to normal weight wild-type mice. In contrast, non-obese, SP-C-Cre+/+/LepR fl/fl and LysM-Cre+/+/LepR fl/fl had improved viral clearance after influenza A infection. In obese mice, mortality was increased compared with wild-type mice, while the SP-C-Cre+/+/LepR fl/fl and LysM-Cre+/+/LepR fl/fl mice exhibited improved survival.Global loss of the leptin receptor results in reduced viral clearance and worse outcomes following influenza A infection. These findings are not the result of the loss of leptin signaling in lung epithelial cells or macrophages. Our results suggest that factors associated with obesity or with leptin signaling in non-myeloid populations such as natural killer and T cells may be associated with worsened outcomes following influenza A infection.

  13. Characterization of Ca2+ Signalling in Postnatal Mouse Retinal Ganglion Cells: Involvement of OPA1 in Ca2+ Clearance

    Czech Academy of Sciences Publication Activity Database

    Dayanithi, Govindan; Chen-Kuo-Chang, M.; Viero, C.; Hamel, C.; Muller, A.; Lenaers, G.

    2010-01-01

    Roč. 31, č. 2 (2010), s. 53-65. ISSN 1381-6810 Institutional research plan: CEZ:AV0Z50390703 Keywords : retinal ganglion cells * Ca2+ homeostasis * Ca2+ clearance Subject RIV: FH - Neurology Impact factor: 1.333, year: 2010

  14. Correlation analysis with neutron count distributions in randomly or signal triggered time intervals for assay of special fissile materials

    International Nuclear Information System (INIS)

    A mathematical model is derived for the probability distribution of neutron signal multiplets inside randomly and signal triggered time intervals for a generalized time response function of the neutron detector assembly. The theory is applied to assemblies with an exponential time decay of its neutron population. The probability distributions, their factorial moments, and moments are expressed as a function of the spontaneous fission rate, (α-n) reaction rate, neutron detection probability, probability that a neutron generates a fast fission, and nuclear data. Measurements with plutonium sample are analyzed to check the derived algorithms for the factorial moments of the two probability distributions

  15. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    NARCIS (Netherlands)

    Arking, Dan E.; Pulit, Sara L.; Crotti, Lia; Van der Harst, Pim; Munroe, Patricia B.; Koopmann, Tamara T.; Sotoodehnia, Nona; Rossin, Elizabeth J.; Morley, Michael; Wang, Xinchen; Johnson, Andrew D.; Lundby, Alicia; Gudbjartsson, Daniel F.; Noseworthy, Peter A.; Eijgelsheim, Mark; Bradford, Yuki; Tarasov, Kirill V.; Dorr, Marcus; Miiller-Nurasyid, Martina; Lahtinen, Annukka M.; Nolte, Ilja M.; Smith, Albert Vernon; Bis, Joshua C.; Isaacs, Aaron; Newhouse, Stephen J.; Evans, Daniel S.; Post, Wendy S.; Waggott, Daryl; Lyytikainen, Leo-Pekka; Hicks, Andrew A.; Eisele, Lewin; Ellinghaus, David; Hayward, Caroline; Navarro, Pau; Ulivi, Sheila; Tanaka, Toshiko; Tester, David J.; Chatel, Stephanie; Gustafsson, Stefan; Kumari, Meena; Morris, Richard W.; Naluai, Asa T.; Padmanabhan, Sandosh; Kluttig, Alexander; Strohmer, Bernhard; Panayiotou, Andrie G.; Torres, Maria; Knoflach, Michael; Hubacek, Jaroslav A.; Slowikowski, Kamil; Raychaudhuri, Soumya; Kumar, Runjun D.; Harris, Tamara B.; Launer, Lenore J.; Shuldiner, Alan R.; Alonso, Alvaro; Bader, Joel S.; EhreT, Georg; Huang, Hailiang; Kao, W. H. Linda; Strait, James B.; Macfarlane, Peter W.; Brown, Morris; Caulfield, Mark J.; Samani, Nilesh J.; Kronenberg, Florian; Willeit, Johann; Smith, J. Gustav; Greiser, Karin H.; Schwabedissen, Henriette Meyer Zu; Werdan, Karl; Carella, Massimo; Zelante, Leopoldo; Heckbert, Susan R.; Psaty, Bruce M.; Rotter, Jerome I.; Kolcic, Ivana; Poagek, Ozren; Wright, Alan F.; Griffin, Maura; Daly, Mark J.; Arnar, David O.; Holm, Hilma; Thorsteinsdottir, Unnur; Denny, Joshua C.; Roden, Dan M.; Zuvich, Rebecca L.; Emilsson, Valur; Plump, Andrew S.; Larson, Martin G.; O'Donnell, Christopher J.; Yin, Xiaoyan; Bobboll, Marco; D'Adamo, Adamo P.; Iorio, Annamaria; Sinagra, Gianfranco; Carracedo, Angel; Cummings, Steven R.; Nalls, Michael A.; Jula, Antti; Kontula, Kimmo K.; Marjamaa, Annukka; Oikarinen, Lasse; Perola, Markus; Porthan, Kimmo; Erbe, Raimund; Hoffmann, Per; Jockel, Karl-Heinz; Kalsch, Hagen; Nothen, Markus M.; Den Hoed, Marcel; Loos, Ruth J. F.; Thelle, Dag S.; Gieger, Christian; Meitinger, Thomas; Perz, Siegfried; Peters, Annette; Pruchal, Hanna; Sinner, Moritz F.; Waldenberger, Melanie; De Boer, Rudolf A.; Franke, Lude; Van der Vleuten, Pieter A.; Beckmann, Britt Maria; Martens, Eimo; Bardail, Abdennasser; Hofman, Nynke; Wilde, Arthur A. M.; Behr, Elijah R.; Dalageorgou, Chrysoula; Giudicessi, John R.; Medeiros-Domingo, Argelia; Barc, Julien; Kyndt, Florence; Probst, Vincent; Ghidoni, Alice; Insolia, Roberto; Hamilton, Robert M.; Scherer, Stephen W.; Brandimarto, Jeffrey; Margulies, Kenneth; Moravec, Christine E.; Del Greco, Fabiola; Fuchsberger, Christian; O'Connell, Jeffrey R.; Lee, Wai K.; Watt, Graham C. M.; Campbell, Harry; Wild, Sarah H.; El Mokhtari, Nour E.; Frey, Norbert; Asselbergs, Folkert W.; Mateo Leach, Irene; Navis, Gerjan; Van den Berg, Maarten P.; Van Veldhuisen, Dirk J.; Kellis, Manolis; Krijthe, Bouwe P.; Franco, Oscar H.; Hofman, Albert; Kors, Jan A.; Uitterlinden, Andre G.; Witteman, Jacqueline C. M.; Kedenko, Lyudmyla; Lamina, Claudia; Oostra, Ben A.; Abecasis, Goncalo R.; Lakatta, Edward G.; Mulas, Antonella; Orru, Marco; Schlessinger, David; Uda, Manuela; Markus, Marcello R. P.; Volker, Uwe; Snieder, Harold; Spector, Timothy D.; Arnlov, Johan; Lind, Lars; Sundstrom, Johan; Syvanen, Ann-Christine; Kivimaki, Mika; Kahonen, Mika; Mononen, Nina; Raitakari, I. T.; Viikari, Jorma S.; Adamkova, Vera; Kiech, Stefan; Brion, Maria; Nicolaides, Andrew N.; Paulweber, Bernhard; Haerting, Johannes; Dominiczak, Anna F.; Nyberg, Fredrik; Whincup, Peter H.; Hingorani, Aroon D.; Schott, Jean-Jacques; Bezzina, Connie R.; Ingelsson, Erik; Ferrucci, Luigi; Gaspariniin, Paolo; Wilson, James F.; Rudan, Igor; Franke, Andre; Miihleisen, Thomas W.; Pramstaller, Peter P.; Lehtimaki, Terho J.; Paterson, Andrew D.; Parsa, Afshin; Liu, Yongmei; Van Duijn, Cornelia M.; Siscovick, David S.; Gudnason, Vilmundur; Jamshidi, Yalda; Salomaa, Veikko; Felix, Stephan B.; Sanna, Serena; Ritchie, Marylyn D.; Stricker, Bruno H.; Stefansson, Karl; Boyer, Laurie A.; Cappola, Thomas P.; Olsen, Jesper V.; Lage, Kasper; Schwartz, Peter J.; Kaab, Stefan; Chakravarti, Aravinda; Ackerman, Michael J.; Pfeufer, Arne; De Bakker, Paul I. W.; Newton-Cheh, Christopher

    2014-01-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using

  16. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    DEFF Research Database (Denmark)

    Arking, Dan E; Pulit, Sara L; Crotti, Lia;

    2014-01-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Usi...

  17. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    NARCIS (Netherlands)

    D.E. Arking (Dan); S.L. Pulit (Sara); L. Crotti (Lia); P. van der Harst (Pim); P. Munroe (Patricia); T.T. Koopmann (Tamara); N. Sotoodehnia (Nona); E. Rossin (Elizabeth); M. Morley (Michael); X. Wang (Xinchen); A.D. Johnson (Andrew); A. Lundby (Alicia); D.F. Gudbjartsson (Daniel); P.A. Noseworthy (Peter); M. Eijgelsheim (Mark); Y. Bradford (Yuki); K.V. Tarasov (Kirill); M. Dörr (Marcus); M. Müller-Nurasyid (Martina); A.M. Lahtinen (Annukka); I.M. Nolte (Ilja); G.D. Smith; J.C. Bis (Joshua); A.J. Isaacs (Aaron); S.J. Newhouse (Stephen); D.S. Evans (Daniel); W.S. Post (Wendy S.); D. Waggott (Daryl); L.-P. Lyytikäinen (Leo-Pekka); A.A. Hicks (Andrew); L. Eisele (Lewin); D. Ellinghaus (David); C. Hayward (Caroline); P. Navarro (Pau); S. Ulivi (Shelia); T. Tanaka (Toshiko); D.J. Tester (David); S. Chatel (Stéphanie); S. Gustafsson (Stefan); M. Kumari (Meena); R. Morris (Richard); A.T. Naluai (Asa); S. Padmanabhan (Sandosh); A. Kluttig (Alexander); B. Strohmer (Bernhard); A.G. Panayiotou (Andrie); M. Torres (Maria); M. Knoflach (Michael); J.A. Hubacek (Jaroslav A.); K. Slowikowski (Kamil); S. Raychaudhuri (Soumya); R.D. Kumar (Runjun); T.B. Harris (Tamara); L.J. Launer (Lenore); A.R. Shuldiner (Alan); A. Alonso (Alvaro); J.S. Bader (Joel); G.B. Ehret (Georg); H. Huang (Hailiang); W.H.L. Kao (Wen); J.B. Strait (James); P.W. Macfarlane (Peter); M.J. Brown (Morris); M. Caulfield (Mark); N.J. Samani (Nilesh); F. Kronenberg (Florian); J. Willeit (Johann); J.G. Smith (J. Gustav); K.H. Greiser (Karin Halina); H.M. Zu Schwabedissen (Henriette Meyer); K. Werdan (Karl); C. Carella (Cintia); L. Zelante (Leopoldo); S.R. Heckbert (Susan); B.M. Psaty (Bruce); J.I. Rotter (Jerome); I. Kolcic (Ivana); O. Polasek (Ozren); A.F. Wright (Alan); M. Griffin (Maura); M.J. Daly (Mark); D.O. Arnar (David); H. Hólm (Hilma); U. Thorsteinsdottir (Unnur); J.C. Denny (Joshua); D.M. Roden (Dan); R.L. Zuvich (Rebecca); V. Emilsson (Valur); A.S. Plump (Andrew); M.G. Larson (Martin); C.J. O'Donnell (Christopher); X. Yin (Xiaoyan); M. Bobbo (Marco); P. D'Adamo (Pio); A. Iorio (Annamaria); G. Sinagra (Gianfranco); A. Carracedo (Angel); S.R. Cummings (Steven); M.A. Nalls (Michael); A. Jula (Antti); K.K. Kontula (Kimmo); A. Marjamaa (Annukka); L. Oikarinen (Lasse); M. Perola (Markus); K. Porthan (Kimmo); R. Erbel (Raimund); P. Hoffmann (Per); K.-H. Jöckel (Karl-Heinz); H. Kälsch (Hagen); M.M. Nöthen (Markus); M. den Hoed (Marcel); R.J.F. Loos (Ruth); D.S. Thelle (Dag); C. Gieger (Christian); T. Meitinger (Thomas); S. Perz (Siegfried); A. Peters (Annette); H. Prucha (Hanna); M.F. Sinner (Moritz); M. Waldenberger (Melanie); R.A. de Boer (Rudolf); L. Franke (Lude); P.A. van der Vleuten (Pieter); B.M. Beckmann (Britt); E. Martens (Eimo); A. Bardai (Abdennasser); N. Hofman (Nynke); A.A.M. Wilde (Arthur); E.R. Behr (Elijah ); C. Dalageorgou (Chrysoula); J.R. Giudicessi (John); A. Medeiros-Domingo (Argelia); J. Barc (Julien); F. Kyndt (Florence); V. Probst (Vincent); A. Ghidoni (Alice); R. Insolia (Roberto); R.M. Hamilton (Robert); S.W. Scherer (Stephen); J. Brandimarto (Jeffrey); K. Margulies (Kenneth); C.E. Moravec (Christine); F. Del Greco M (Fabiola); C. Fuchsberger (Christian); J.R. O'Connell (Jeffery); W.K. Lee (Wai); G.C.M. Watt (Graham); H. Campbell (Harry); S.H. Wild (Sarah); N.E. El Mokhtari (Nour); N. Frey (Norbert); F.W. Asselbergs (Folkert); I.M. Leach (Irene Mateo); G. Navis (Gerjan); M.P. van den Berg (Maarten); D.J. van Veldhuisen (Dirk); M. Kellis (Manolis); B.P. Krijthe (Bouwe); O.H. Franco (Oscar); A. Hofman (Albert); J.A. Kors (Jan); A.G. Uitterlinden (André); J.C.M. Witteman (Jacqueline); L. Kedenko (Lyudmyla); C. Lamina (Claudia); B.A. Oostra (Ben); G.R. Abecasis (Gonçalo); E. Lakatta (Edward); A. Mulas (Antonella); M. Orrù (Marco); D. Schlessinger (David); M. Uda (Manuela); M.R.P. Markus (Marcello R. P.); U. Völker (Uwe); H. Snieder (Harold); T.D. Spector (Timothy); J. Ärnlöv (Johan); L. Lind (Lars); J. Sundstrom (Johan); A.C. Syvanen; M. Kivimaki (Mika); M. Kähönen (Mika); K. Mononen (Kari); O. Raitakari (Olli); J. Viikari (Jorma); V. Adamkova (Vera); S. Kiechl (Stefan); M.-J. Brion (Maria); A.N. Nicolaides (Andrew); B. Paulweber (Bernhard); J. Haerting (Johannes); A. Dominiczak (Anna); F. Nyberg (Fredrik); P.H. Whincup (Peter); A. Hingorani (Aroon); J.-J. Schott (Jean-Jacques); C.R. Bezzina (Connie); E. Ingelsson (Erik); L. Ferrucci (Luigi); P. Gasparini (Paolo); J.F. Wilson (James); I. Rudan (Igor); A. Franke (Andre); T.W. Mühleisen (Thomas); P.P. Pramstaller (Peter Paul); T. Lehtimäki (Terho); A.D. Paterson (Andrew); A. Parsa (Afshin); Y. Liu (Yongmei); C.M. van Duijn (Cock); D.S. Siscovick (David); V. Gudnason (Vilmundur); Y. Jamshidi (Yalda); V. Salomaa (Veikko); S.B. Felix (Stephan); S. Sanna (Serena); M.D. Ritchie (Marylyn); B.H.Ch. Stricker (Bruno); J-A. Zwart (John-Anker); L.A. Boyer (Laurie); T.P. Cappola (Thomas); J.V. Olsen (Jesper); P. Lage (Pedro); P.J. Schwartz (Peter); S. Kääb (Stefan); A. Chakravarti (Aravinda); M. Ackerman (Margaret); A. Pfeufer (Arne); P.I.W. de Bakker (Paul); C. Newton-Cheh (Christopher)

    2014-01-01

    textabstractThe QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (L

  18. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

    Science.gov (United States)

    Arking, Dan E; Pulit, Sara L; Crotti, Lia; van der Harst, Pim; Munroe, Patricia B; Koopmann, Tamara T; Sotoodehnia, Nona; Rossin, Elizabeth J; Morley, Michael; Wang, Xinchen; Johnson, Andrew D; Lundby, Alicia; Gudbjartsson, Daníel F; Noseworthy, Peter A; Eijgelsheim, Mark; Bradford, Yuki; Tarasov, Kirill V; Dörr, Marcus; Müller-Nurasyid, Martina; Lahtinen, Annukka M; Nolte, Ilja M; Smith, Albert Vernon; Bis, Joshua C; Isaacs, Aaron; Newhouse, Stephen J; Evans, Daniel S; Post, Wendy S; Waggott, Daryl; Lyytikäinen, Leo-Pekka; Hicks, Andrew A; Eisele, Lewin; Ellinghaus, David; Hayward, Caroline; Navarro, Pau; Ulivi, Sheila; Tanaka, Toshiko; Tester, David J; Chatel, Stéphanie; Gustafsson, Stefan; Kumari, Meena; Morris, Richard W; Naluai, Åsa T; Padmanabhan, Sandosh; Kluttig, Alexander; Strohmer, Bernhard; Panayiotou, Andrie G; Torres, Maria; Knoflach, Michael; Hubacek, Jaroslav A; Slowikowski, Kamil; Raychaudhuri, Soumya; Kumar, Runjun D; Harris, Tamara B; Launer, Lenore J; Shuldiner, Alan R; Alonso, Alvaro; Bader, Joel S; Ehret, Georg; Huang, Hailiang; Kao, W H Linda; Strait, James B; Macfarlane, Peter W; Brown, Morris; Caulfield, Mark J; Samani, Nilesh J; Kronenberg, Florian; Willeit, Johann; Smith, J Gustav; Greiser, Karin H; Meyer Zu Schwabedissen, Henriette; Werdan, Karl; Carella, Massimo; Zelante, Leopoldo; Heckbert, Susan R; Psaty, Bruce M; Rotter, Jerome I; Kolcic, Ivana; Polašek, Ozren; Wright, Alan F; Griffin, Maura; Daly, Mark J; Arnar, David O; Hólm, Hilma; Thorsteinsdottir, Unnur; Denny, Joshua C; Roden, Dan M; Zuvich, Rebecca L; Emilsson, Valur; Plump, Andrew S; Larson, Martin G; O'Donnell, Christopher J; Yin, Xiaoyan; Bobbo, Marco; D'Adamo, Adamo P; Iorio, Annamaria; Sinagra, Gianfranco; Carracedo, Angel; Cummings, Steven R; Nalls, Michael A; Jula, Antti; Kontula, Kimmo K; Marjamaa, Annukka; Oikarinen, Lasse; Perola, Markus; Porthan, Kimmo; Erbel, Raimund; Hoffmann, Per; Jöckel, Karl-Heinz; Kälsch, Hagen; Nöthen, Markus M; den Hoed, Marcel; Loos, Ruth J F; Thelle, Dag S; Gieger, Christian; Meitinger, Thomas; Perz, Siegfried; Peters, Annette; Prucha, Hanna; Sinner, Moritz F; Waldenberger, Melanie; de Boer, Rudolf A; Franke, Lude; van der Vleuten, Pieter A; Beckmann, Britt Maria; Martens, Eimo; Bardai, Abdennasser; Hofman, Nynke; Wilde, Arthur A M; Behr, Elijah R; Dalageorgou, Chrysoula; Giudicessi, John R; Medeiros-Domingo, Argelia; Barc, Julien; Kyndt, Florence; Probst, Vincent; Ghidoni, Alice; Insolia, Roberto; Hamilton, Robert M; Scherer, Stephen W; Brandimarto, Jeffrey; Margulies, Kenneth; Moravec, Christine E; del Greco M, Fabiola; Fuchsberger, Christian; O'Connell, Jeffrey R; Lee, Wai K; Watt, Graham C M; Campbell, Harry; Wild, Sarah H; El Mokhtari, Nour E; Frey, Norbert; Asselbergs, Folkert W; Mateo Leach, Irene; Navis, Gerjan; van den Berg, Maarten P; van Veldhuisen, Dirk J; Kellis, Manolis; Krijthe, Bouwe P; Franco, Oscar H; Hofman, Albert; Kors, Jan A; Uitterlinden, André G; Witteman, Jacqueline C M; Kedenko, Lyudmyla; Lamina, Claudia; Oostra, Ben A; Abecasis, Gonçalo R; Lakatta, Edward G; Mulas, Antonella; Orrú, Marco; Schlessinger, David; Uda, Manuela; Markus, Marcello R P; Völker, Uwe; Snieder, Harold; Spector, Timothy D; Ärnlöv, Johan; Lind, Lars; Sundström, Johan; Syvänen, Ann-Christine; Kivimaki, Mika; Kähönen, Mika; Mononen, Nina; Raitakari, Olli T; Viikari, Jorma S; Adamkova, Vera; Kiechl, Stefan; Brion, Maria; Nicolaides, Andrew N; Paulweber, Bernhard; Haerting, Johannes; Dominiczak, Anna F; Nyberg, Fredrik; Whincup, Peter H; Hingorani, Aroon D; Schott, Jean-Jacques; Bezzina, Connie R; Ingelsson, Erik; Ferrucci, Luigi; Gasparini, Paolo; Wilson, James F; Rudan, Igor; Franke, Andre; Mühleisen, Thomas W; Pramstaller, Peter P; Lehtimäki, Terho J; Paterson, Andrew D; Parsa, Afshin; Liu, Yongmei; van Duijn, Cornelia M; Siscovick, David S; Gudnason, Vilmundur; Jamshidi, Yalda; Salomaa, Veikko; Felix, Stephan B; Sanna, Serena; Ritchie, Marylyn D; Stricker, Bruno H; Stefansson, Kari; Boyer, Laurie A; Cappola, Thomas P; Olsen, Jesper V; Lage, Kasper; Schwartz, Peter J; Kääb, Stefan; Chakravarti, Aravinda; Ackerman, Michael J; Pfeufer, Arne; de Bakker, Paul I W; Newton-Cheh, Christopher

    2014-08-01

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD. PMID:24952745

  19. The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing.

    Science.gov (United States)

    Han, Arum; Bandyopadhyay, Balaji; Jayaprakash, Priyamvada; Lua, Ingrid; Sahu, Divya; Chen, Mei; Woodley, David T; Li, Wei

    2012-12-15

    When skin is wounded, migration of epidermal keratinocytes at the wound edge initiates within hours, whereas migration of dermal fibroblasts toward the wounded area remains undetectable until several days later. This "cell type traffic" regulation ensures proper healing of the wound, as disruptions of the regulation could either cause delay of wound healing or result in hypertrophic scars. TGFβ3 is the critical traffic controller that selectively halts migration of the dermal, but not epidermal, cells to ensure completion of wound re-epithelialization prior to wound remodeling. However, the mechanism of TGFβ3's anti-motility signaling has never been investigated. We report here that activated TβRII transmits the anti-motility signal of TGFβ3 in full to TβRI, since expression of the constitutively activated TβRI-TD mutant was sufficient to replace TGFβ3 to block PDGF-bb-induced dermal fibroblast migration. Second, the three components of R-Smad complex are all required. Individual downregulation of Smad2, Smad3 or Smad4 prevented TGFβ3 from inhibiting dermal fibroblast migration. Third, Protein Kinase Array allowed us to identify the protein kinase A (PKA) as a specific downstream effector of R-Smads in dermal fibroblasts. Activation of PKA alone blocked PDGF-bb-induced dermal fibroblast migration, just like TGFβ3. Downregulation of PKA's catalytic subunit nullified the anti-motility signaling of TGFβ3. This is the first report on anti-motility signaling mechanism by TGFβ family cytokines. Significance of this finding is not only limited to wound healing but also to other human disorders, such as heart attack and cancer, where the diseased cells have often managed to avoid the anti-motility effect of TGFβ. PMID:23259050

  20. 49 CFR Appendix F to Part 512 - OMB Clearance

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false OMB Clearance F Appendix F to Part 512 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONFIDENTIAL BUSINESS INFORMATION Pt. 512, App. F Appendix F to Part 512—OMB Clearance The OMB clearance...

  1. Prediction of paroxysmal atrial fibrillation using recurrence plot-based features of the RR-interval signal

    International Nuclear Information System (INIS)

    Atrial fibrillation (AF) is the most common cardiac arrhythmia and increases the risk of stroke. Predicting the onset of paroxysmal AF (PAF), based on noninvasive techniques, is clinically important and can be invaluable in order to avoid useless therapeutic intervention and to minimize risks for the patients. In this paper, we propose an effective PAF predictor which is based on the analysis of the RR-interval signal. This method consists of three steps: preprocessing, feature extraction and classification. In the first step, the QRS complexes are detected from the electrocardiogram (ECG) signal and then the RR-interval signal is extracted. In the next step, the recurrence plot (RP) of the RR-interval signal is obtained and five statistically significant features are extracted to characterize the basic patterns of the RP. These features consist of the recurrence rate, length of longest diagonal segments (Lmax ), average length of the diagonal lines (Lmean), entropy, and trapping time. Recurrence quantification analysis can reveal subtle aspects of dynamics not easily appreciated by other methods and exhibits characteristic patterns which are caused by the typical dynamical behavior. In the final step, a support vector machine (SVM)-based classifier is used for PAF prediction. The performance of the proposed method in prediction of PAF episodes was evaluated using the Atrial Fibrillation Prediction Database (AFPDB) which consists of both 30 min ECG recordings that end just prior to the onset of PAF and segments at least 45 min distant from any PAF events. The obtained sensitivity, specificity, positive predictivity and negative predictivity were 97%, 100%, 100%, and 96%, respectively. The proposed methodology presents better results than other existing approaches

  2. Traffic sounds and cycling safety : the use of electronic devices by cyclists and the quietness of hybrid and electric cars.

    OpenAIRE

    Stelling-Konczak, A. Hagenzieker, M. & Wee, B. van

    2015-01-01

    The growing popularity of electric devices and the increasing number of hybrid and electric cars have recently raised concerns about the use of auditory signals by vulnerable road users. This paper consolidates current knowledge about the two trends in relation to cycling safety. Both a literature review and a crash data analysis were carried out. Based on a proposed conceptual model, knowledge gaps are identified that need to be addressed for a better understanding of the relation between li...

  3. WSN Applications: Automated Intelligent Traffic Control System Using Sensors

    OpenAIRE

    Rashid Hussain; Sandhyasharma; Vinita Sharma; Sandhya Sharma

    2013-01-01

    In this new Era the growing Vehicle population in all developing and developed country calls for a major improvement and innovation in the existing Traffic Signaling systems. The most widely used automated system uses a simple time based system which working on a time interval basis which is now inefficient for random and non uniform Traffic. Advance automated systems in testing use image processing techniques or advance communication system with an intelligent information gathering systems i...

  4. Noncoding RNA mediated traffic of foreign mRNA into chloroplasts reveals a novel signaling mechanism in plants.

    Directory of Open Access Journals (Sweden)

    Gustavo Gómez

    Full Text Available Communication between chloroplasts and the nucleus is one of the milestones of the evolution of plants on earth. Proteins encoded by ancestral chloroplast-endogenous genes were transferred to the nucleus during the endosymbiotic evolution and originated this communication, which is mainly dependent on specific transit-peptides. However, the identification of nuclear-encoded proteins targeted to the chloroplast lacking these canonical signals suggests the existence of an alternative cellular pathway tuning this metabolic crosstalk. Non-coding RNAS (NcRNAs are increasingly recognized as regulators of gene expression as they play roles previously believed to correspond to proteins. Avsunviroidae family viroids are the only noncoding functional RNAs that have been reported to traffic inside the chloroplasts. Elucidating mechanisms used by these pathogens to enter this organelle will unearth novel transport pathways in plant cells. Here we show that a viroid-derived NcRNA acting as a 5'UTR-end mediates the functional import of Green Fluorescent Protein (GFP mRNA into chloroplast. This claim is supported by the observation at confocal microscopy of a selective accumulation of GFP in the chloroplast of the leaves expressing the chimeric vd-5'UTR/GFP and by the detection of the GFP mRNA in chloroplasts isolated from cells expressing this construct. These results support the existence of an alternative signaling mechanism in plants between the host cell and chloroplasts, where an ncRNA functions as a key regulatory molecule to control the accumulation of nuclear-encoded proteins in this organelle. In addition, our findings provide a conceptual framework to develop new biotechnological tools in systems using plant chloroplast as bioreactors. Finally, viroids of the family Avsunviroidae have probably evolved to subvert this signaling mechanism to regulate their differential traffic into the chloroplast of infected cells.

  5. Traffic Square Management System

    OpenAIRE

    Sujata V. Padole

    2013-01-01

    If the traffic is more on one side and less on other side so there all way a waste of time and fuel on the traffic signal. Which is serious problem now day so there an need to have an intelligent traffic system which can detect the amount of traffic and make the change accordingly by using sensor and tranducer. Also by using motion detection camera at the lane we can find out the vehicle owner who break the traffic rules at the signal.

  6. Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice

    OpenAIRE

    Kooijman, Sander; Wang, Yanan; Parlevliet, Edwin T.; Boon, Mariëtte R.; Edelschaap, David; Snaterse, Gido; Pijl, Hanno; Romijn, Johannes A.; Rensen, Patrick C. N.

    2015-01-01

    Aims/hypothesis Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonism, used in the treatment of type 2 diabetes, has recently been shown to increase thermogenesis via the brain. As brown adipose tissue (BAT) produces heat by burning triacylglycerol (TG) and takes up glucose for de novo lipogenesis, the aim of this study was to evaluate the potential of chronic central GLP-1R activation by exendin-4 to facilitate clearance of lipids and glucose from the circulation by activating BAT. Metho...

  7. Re-entry flight clearance

    OpenAIRE

    Juliana, S.

    2006-01-01

    The objective of the research was to identify and evaluate promising mathematical techniques for re-entry flight clearance. To fulfil this objective, two mathematical methods were investigated and developed: μ analysis for linear models and interval analysis for both linear and non-linear models. The stability of re-entry vehicles in the presence of model uncertainties was chosen as the clearance criterion, which is represented by two mathematical criteria: worst-case eigenvalues (linear...

  8. Engineering information on an Analog Signal to Discrete Time Interval Converter (ASDT-IC)

    Science.gov (United States)

    Schwarz, F. C.

    1974-01-01

    An electronic control system for nondissipative dc power converters is presented which improves (1) the routinely attainable static output voltage accuracy to the order of + or - 1% for ambient temperatures from -55 to 100 C and (2) the dynamic stability by utilizing approximately one tenth of the feedback gain needed otherwise. Performance is due to a functional philosophy of deterministic pulse modulation based on pulse area control and to an autocompensated signal processing principle. The system can be implemented with commercially available unselected components.

  9. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

    NARCIS (Netherlands)

    Peeper, D.S.; Upton, T.M.; Ladha, M.H.; Neuman, E.; Zalvide, J.; Bernards, R.A.; DeCaprio, J.A.; Ewen, M.E.

    1997-01-01

    The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (GO) and to pass through the GI/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, howev

  10. Small signal with background: objective confidence intervals and regions for physical parameters from the principle of maximum likelihood

    International Nuclear Information System (INIS)

    It is argued that the choice between one-sided and two-sided confidence intervals must be made according to a rule prior to and independent of the data and it is shown that such a rule was found in principle by a statistician about half a century ago. The novel problem with unphysical estimates of a parameter in presence of background is solved in the realm of classical statistics by applying this rule and the principle of maximum likelihood. Optimal confidence intervals are given for the measurement of a bounded magnitude with normal errors, most effective in discriminating a signal next to the bound, and it is shown how to get them in any single case for a bounded discrete variable with background, in general and specifically for Poisson and binomial variables, with two examples of application. The upper limit provided by this method, when the data are consistent with no signal, does not decrease with unphysical estimates going far off the physical values, so removing the last claimed support of Bayesian inference in physics. Procedure are given extending the method to several parameters

  11. Bootstrap Signal-to-Noise Confidence Intervals: An Objective Method for Subject Exclusion and Quality Control in ERP Studies.

    Science.gov (United States)

    Parks, Nathan A; Gannon, Matthew A; Long, Stephanie M; Young, Madeleine E

    2016-01-01

    Analysis of event-related potential (ERP) data includes several steps to ensure that ERPs meet an appropriate level of signal quality. One such step, subject exclusion, rejects subject data if ERP waveforms fail to meet an appropriate level of signal quality. Subject exclusion is an important quality control step in the ERP analysis pipeline as it ensures that statistical inference is based only upon those subjects exhibiting clear evoked brain responses. This critical quality control step is most often performed simply through visual inspection of subject-level ERPs by investigators. Such an approach is qualitative, subjective, and susceptible to investigator bias, as there are no standards as to what constitutes an ERP of sufficient signal quality. Here, we describe a standardized and objective method for quantifying waveform quality in individual subjects and establishing criteria for subject exclusion. The approach uses bootstrap resampling of ERP waveforms (from a pool of all available trials) to compute a signal-to-noise ratio confidence interval (SNR-CI) for individual subject waveforms. The lower bound of this SNR-CI (SNRLB ) yields an effective and objective measure of signal quality as it ensures that ERP waveforms statistically exceed a desired signal-to-noise criterion. SNRLB provides a quantifiable metric of individual subject ERP quality and eliminates the need for subjective evaluation of waveform quality by the investigator. We detail the SNR-CI methodology, establish the efficacy of employing this approach with Monte Carlo simulations, and demonstrate its utility in practice when applied to ERP datasets. PMID:26903849

  12. 一种新型嵌入式网络信号机研究与设计%Study and Design of Embedded Network Traffic Signal Controller

    Institute of Scientific and Technical Information of China (English)

    肖圣兵; 陈锋

    2012-01-01

    Traffic signal controller is one of the main foundations for Intelligent Traffic System. In order to meet intellectualization and network requirements, a novel embedded network signal controller is investigated. ARM and CPLD are used to design hardware structure of signal controller, and humanized user interface is developed using QT/Embedded based on touch screen. Multiple communication interfaces are supported and the communication protocol is defined by XML. The mode of two level conflict check is introduced to avoid green conflict. Single point fuzzy control module is developed to deal with dynamic traffic flow, so as to increase traffic capacity in intersection. Connecting to traffic simulation software that simulates the actual intersectiont experiments show that traffic signal controller works stably, and has excellent performance.%交通信号机是智能交通系统的基础之一,为了满足信号机的网络化和智能化的要求,研究并提出了一种新型的嵌入式网络信号机,该信号机的硬件结构采用ARM和CPLD,以触摸屏为基础采用QT/Embedded设计了人性化的人机接口,信号机支持多种通信接口,其协议采用XML予以定义;为了避免绿冲突,以两级模式进行冲突判断;单点模糊控制机制的设计能够适应动态的交通流状况,有效提高交叉口的通行能力;连接交通仿真软件,模拟实际路口,实验显示该信号机工作稳定,性能优越.

  13. The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing

    Directory of Open Access Journals (Sweden)

    Arum Han

    2012-09-01

    When skin is wounded, migration of epidermal keratinocytes at the wound edge initiates within hours, whereas migration of dermal fibroblasts toward the wounded area remains undetectable until several days later. This “cell type traffic” regulation ensures proper healing of the wound, as disruptions of the regulation could either cause delay of wound healing or result in hypertrophic scars. TGFβ3 is the critical traffic controller that selectively halts migration of the dermal, but not epidermal, cells to ensure completion of wound re-epithelialization prior to wound remodeling. However, the mechanism of TGFβ3's anti-motility signaling has never been investigated. We report here that activated TβRII transmits the anti-motility signal of TGFβ3 in full to TβRI, since expression of the constitutively activated TβRI-TD mutant was sufficient to replace TGFβ3 to block PDGF-bb-induced dermal fibroblast migration. Second, the three components of R-Smad complex are all required. Individual downregulation of Smad2, Smad3 or Smad4 prevented TGFβ3 from inhibiting dermal fibroblast migration. Third, Protein Kinase Array allowed us to identify the protein kinase A (PKA as a specific downstream effector of R-Smads in dermal fibroblasts. Activation of PKA alone blocked PDGF-bb-induced dermal fibroblast migration, just like TGFβ3. Downregulation of PKA's catalytic subunit nullified the anti-motility signaling of TGFβ3. This is the first report on anti-motility signaling mechanism by TGFβ family cytokines. Significance of this finding is not only limited to wound healing but also to other human disorders, such as heart attack and cancer, where the diseased cells have often managed to avoid the anti-motility effect of TGFβ.

  14. Traffic Information System for Hanoi

    OpenAIRE

    Sohr, Alexander; Brockfeld, Elmar; Sauerländer-Biebl, Anke; Melde, Eric

    2016-01-01

    To improve the traffic situation in Hanoi it is necessary to have a good overview of the existing traffic situation and to monitor the development of the traffic over longer time periods. Floating Car Data (FCD) Systems can help to acquire area wide traffic information; here a FCD system based on taxis, busses and motor-cycles is described. It consists of Web and App tools and a Hotspot-Monitoring for long term traffic analysis.

  15. Avoidance Expression in Rats as a Function of Signal-Shock Interval: Strain and Sex Differences

    Directory of Open Access Journals (Sweden)

    Richard J Servatius

    2015-07-01

    Full Text Available Inbred Wistar Kyoto (WKY rats express inhibited temperament, increased sensitivity to stress, and exaggerated expressions of avoidance. A long-standing observation for lever press escape/avoidance learning in rats is the duration of the warning signal (WS determines whether avoidance is expressed over escape. Outbred female Sprague-Dawley (SD rats trained with a 10-s WS efficiently escaped, but failed to exhibit avoidance; avoidance was exhibited to a high degree with WSs longer than 20-s. We examined this longstanding WS duration function and extended it to male SD and male and female WKY rats. A cross-over design with two WS durations (10 s or 60 s was employed. Rats were trained (20 trials/session in four phases: acquisition (10 sessions, extinction (10 sessions, re-acquisition (8 sessions and re-extinction (8 sessions. Consistent with the literature, female and male SD rats failed to express avoidance to an appreciable degree with a 10-s WS. When these rats were switched to a 60-s WS, performance levels in the initial session of training resembled the peak performance of rats trained with a 60-s WS. Therefore, the avoidance relationship was acquired, but not expressed at 10-s WS. Further, poor avoidance at 10-s does not adversely affect expression at 60-s. Failure to express avoidance with a 10-s WS likely reflects contrasting reinforcement value of avoidance, not a reduction in the amount of time available to respond or competing responses. In contrast, WKY rats exhibited robust avoidance with a 10-s WS, which was most apparent in female WKY rats. Exaggerated expression of avoidances by WKY rats, especially female rats, further confirms this inbred strain as a model of anxiety vulnerability.

  16. Two dimensional mixed traffic flow considering the transit traffic

    OpenAIRE

    Lingjiang Kong; Junhui Hu; Li Yang

    2012-01-01

    Based on the two-dimension cellular automaton traffic flow model (BML model), a mixed traffic flow model for urban traffic considering the transit traffic is established in this paper by using the Don't block the box rules. We have investigated the influences of the transit traffic ratio, and found that, in most cases, the urban traffic flow exhibited jam phase. Moreover, focusing on the traffic lights cycle, it is found that the average flow has the periodic fluctuation phenomenon, and we ha...

  17. Modelling mucociliary clearance

    OpenAIRE

    Smith, D.J.; Gaffney, E.A.; Blake, J R

    2008-01-01

    Mathematical modelling of the fluid mechanics of mucociliary clearance (MCC) is reviewed and future challenges for researchers are discussed. The morphology of the bronchial and tracheal airway surface liquid (ASL) and ciliated epithelium are briefly introduced. The cilia beat cycle, beat frequency and metachronal coordination are described, along with the rheology of the mucous layer. Theoretical modelling of MCC from the late 1960s onwards is reviewed, and distinctions between ‘phenomenolog...

  18. Clearance of von Willebrand factor. : Clearance of von Willebrand factor

    OpenAIRE

    Denis, Cécile; Christophe, Olivier; Oortwijn, Beatrijs,; Lenting, Peter,

    2008-01-01

    The life cycle of von Willebrand factor (VWF) comprises a number of distinct steps, ranging from the controlled expression of the VWF gene in endothelial cells and megakaryocytes to the removal of VWF from the circulation. The various aspects of VWF clearance have been the objects of intense research in the last few years, stimulated by observations that VWF clearance is a relatively common component of the pathogenesis of type 1 von Willebrand disease (VWD). Moreover, improving the survival ...

  19. Signaling in Vesicle Traffic: Protein-Lipid Interface in Regulation of Plant Endomembrane Dynamics

    Czech Academy of Sciences Publication Activity Database

    Žárský, Viktor; Potocký, Martin

    Heidelberg: Springer Verlag, 2009 - (Baluska, F.; Mancuso, S.), s. 107-133 ISBN 978-3-540-89227-4 R&D Projects: GA AV ČR IAA6038410; GA AV ČR(CZ) IAA601110916; GA MŠk(CZ) LC06034; GA MŠk ME 841 Institutional research plan: CEZ:AV0Z50380511 Keywords : vesicle trafficking * secretory pathway * lipid signalling Subject RIV: EA - Cell Biology

  20. Concurrent exercise incorporating high-intensity interval or continuous training modulates mTORC1 signaling and microRNA expression in human skeletal muscle.

    Science.gov (United States)

    Fyfe, Jackson J; Bishop, David J; Zacharewicz, Evelyn; Russell, Aaron P; Stepto, Nigel K

    2016-06-01

    We compared the effects of concurrent exercise, incorporating either high-intensity interval training (HIT) or moderate-intensity continuous training (MICT), on mechanistic target of rapamycin complex 1 (mTORC1) signaling and microRNA expression in skeletal muscle, relative to resistance exercise (RE) alone. Eight males (mean ± SD: age, 27 ± 4 yr; V̇o2 peak , 45.7 ± 9 ml·kg(-1)·min(-1)) performed three experimental trials in a randomized order: 1) RE (8 × 5 leg press repetitions at 80% 1-repetition maximum) performed alone and RE preceded by either 2) HIT cycling [10 × 2 min at 120% lactate threshold (LT); HIT + RE] or 3) work-matched MICT cycling (30 min at 80% LT; MICT + RE). Vastus lateralis muscle biopsies were obtained immediately before RE, either without (REST) or with (POST) preceding endurance exercise and +1 h (RE + 1 h) and +3 h (RE + 3 h) after RE. Prior HIT and MICT similarly reduced muscle glycogen content and increased ACC(Ser79) and p70S6K(Thr389) phosphorylation before subsequent RE (i.e., at POST). Compared with MICT, HIT induced greater mTOR(Ser2448) and rps6(Ser235/236) phosphorylation at POST. RE-induced increases in p70S6K and rps6 phosphorylation were not influenced by prior HIT or MICT; however, mTOR phosphorylation was reduced at RE + 1 h for MICT + RE vs. both HIT + RE and RE. Expression of miR-133a, miR-378, and miR-486 was reduced at RE + 1 h for HIT + RE vs. both MICT + RE and RE. Postexercise mTORC1 signaling following RE is therefore not compromised by prior HIT or MICT, and concurrent exercise incorporating HIT, but not MICT, reduces postexercise expression of miRNAs implicated in skeletal muscle adaptation to RE. PMID:27101297

  1. The Krüppel traffic report: Cooperative signals direct KLF8 nuclear transport

    Institute of Scientific and Technical Information of China (English)

    Estefanía Rodríguez; John A Martignetti

    2009-01-01

    @@ The Krüppel-like transcription fac-tor (KLF) family consists of 17 dis-tinct family members involved in the regulation of diverse cellular processes including differentiation, cell prolifera-tion, growth-related signal transduction, angiogenesis and apoptosis (recently reviewed in [1]). In addition to their currently known biologic roles, the discovery that at least one member of the family, KLF6, can be alternatively spliced into biologically active isoforms with antagonistic functions and a dis-tinct subcellular localization pattern [2], highlights the fact that nuclear-cytoplasmic shuttling of KLF proteins may represent an additional layer of functional regulation and the possibility of an even more diverse and completely unexplored role for KLF family mem-bers in both health and disease.

  2. Traffic-Related Air Pollution and QT Interval: Modification by Diabetes, Obesity, and Oxidative Stress Gene Polymorphisms in the Normative Aging Study

    OpenAIRE

    Baja, Emmanuel S; Schwartz, Joel D; Wellenius, Gregory A.; Coull, Brent A.; Zanobetti, Antonella; Vokonas, Pantel S; Suh, Helen H.

    2010-01-01

    Background Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure. Objectives We examined the effects of air pollutants on heart-rate–corrected QT interval (QTc), an electrocardiographic marker of ventricular repolarization, and whether these associations were modified by participant characteristics and genetic polymorphisms related to oxidative stress. Methods We studied repeated measurements of QTc on 580 men from t...

  3. Influences of driver’s attributions on signalized intersection traffic%驾驶员属性对信号灯路口交通流的影响研究

    Institute of Scientific and Technical Information of China (English)

    梅超群

    2014-01-01

    A cellular automaton model is proposed to study the traffic at signalized intersection. The driving behaviors induced by driver’s attribution (gender, driving experience, character, etc. ) are numerically analyzed. Simulation results show that the rusty driving skills or tension driving, impatient driving and so on can lead to the transition from free flow to congestion more easily, and these behaviors are the important cause for low travel efficiency at the intersection; the signal cycle is the main factor influencing traffic flux and travel time fairness.%采用元胞自动机模型研究信号灯路口的交通流特性,系统地分析了与性别、驾驶经验、性格等驾驶员属性相关的驾驶行为对交通流的影响。数值模拟发现,技术生疏或紧张驾驶、急躁行驶等驾驶行为更易引发自由流到阻塞流的相变,是路口通行低效率及事故隐患的重要原因,信号周期是影响流量与个人通行时间公平的主要因素。

  4. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

    OpenAIRE

    Peeper, D.S.; Upton, T.M.; Ladha, M H; Neuman, E; Zalvide, J; Bernards, R.A.; DeCaprio, J A; Ewen, M E

    1997-01-01

    The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (GO) and to pass through the GI/S transition of the cell cycle. The mechanism by which Ras signalling regulates cell-cycle progression is unclear, however. Here we report that the retinoblastoma tumour-suppressor protein (Rb), a regulator of GI exit, functionally links Ras to passage through the Gl phase. Inactivation of Ras in cycling cells cause...

  5. Hedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exit.

    Directory of Open Access Journals (Sweden)

    Phing Chian Chai

    Full Text Available In Drosophila postembryonic neuroblasts, transition in gene expression programs of a cascade of transcription factors (also known as the temporal series acts together with the asymmetric division machinery to generate diverse neurons with distinct identities and regulate the end of neuroblast proliferation. However, the underlying mechanism of how this "temporal series" acts during development remains unclear. Here, we show that Hh signaling in the postembryonic brain is temporally regulated; excess (earlier onset of Hh signaling causes premature neuroblast cell cycle exit and under-proliferation, whereas loss of Hh signaling causes delayed cell cycle exit and excess proliferation. Moreover, the Hh pathway functions downstream of Castor but upstream of Grainyhead, two components of the temporal series, to schedule neuroblast cell cycle exit. Interestingly, hh is likely a target of Castor. Hence, Hh signaling provides a link between the temporal series and the asymmetric division machinery in scheduling the end of neurogenesis.

  6. IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance.

    Science.gov (United States)

    Patin, Emmanuel C; Jones, Adam V; Thompson, Aiysha; Clement, Mathew; Liao, Chia-Te; Griffiths, James S; Wallace, Leah E; Bryant, Clare E; Lang, Roland; Rosenstiel, Philip; Humphreys, Ian R; Taylor, Philip R; Jones, Gareth W; Orr, Selinda J

    2016-07-01

    Candida spp. elicit cytokine production downstream of various pathogen recognition receptors, including C-type lectin-like receptors, TLRs, and nucleotide oligomerization domain (NOD)-like receptors. IL-12 family members IL-12p70 and IL-23 are important for host immunity against Candida spp. In this article, we show that IL-27, another IL-12 family member, is produced by myeloid cells in response to selected Candida spp. We demonstrate a novel mechanism for Candida parapsilosis-mediated induction of IL-27 in a TLR7-, MyD88-, and NOD2-dependent manner. Our data revealed that IFN-β is induced by C. parapsilosis, which in turn signals through the IFN-α/β receptor and STAT1/2 to induce IL-27. Moreover, IL-27R (WSX-1)-deficient mice systemically infected with C. parapsilosis displayed enhanced pathogen clearance compared with wild-type mice. This was associated with increased levels of proinflammatory cytokines in the serum and increased IFN-γ and IL-17 responses in the spleens of IL-27R-deficient mice. Thus, our data define a novel link between C. parapsilosis, TLR7, NOD2, IFN-β, and IL-27, and we have identified an important role for IL-27 in the immune response against C. parapsilosis Overall, these findings demonstrate an important mechanism for the suppression of protective immune responses during infection with C. parapsilosis, which has potential relevance for infections with other fungal pathogens. PMID:27259855

  7. T cell traffic signals

    OpenAIRE

    Van Epps, Heather L.

    2005-01-01

    In 1990, Charles Mackay and colleagues combined classical physiology with modern molecular biology to provide the first concrete evidence that naive and memory T cells follow distinct migratory routes out of the bloodstream— a discovery that helped invigorate the field of lymphocyte homing.

  8. Impact of local traffic exclusion on near-road air quality: Findings from the New York City 'Summer Streets' campaign

    International Nuclear Information System (INIS)

    We monitored curbside airborne particulate matter (PM) concentrations and its proinflammatory capacity during 3 weekends when vehicle traffic was excluded from Park. Ave., New York City. Fine PM concentration peaked in the morning regardless of traffic while ultrafine PM was 58% lower during mornings without traffic. Ultrafine PM concentration varied linearly with traffic flow, while fine PM spiked sharply in response to random traffic events that were weakly correlated with the traffic signal cycle. Ultrafine PM concentrations decayed exponentially with distance from a cross street with unrestricted traffic flow, reaching background levels within 100 m of the source. IL-6 induction was typically highest on Friday afternoons but showed no clear relationship to the presence of traffic. The coarse fraction (>2.5 μm) had the greatest intrinsic inflammatory capacity, suggesting that coarse PM still warrants attention even as the research focus is shifting to nano-particles. - Highlights: → During a period of traffic exclusion morning PM2.5 concentration remained high. → Ultrafine concentrations were lower during mornings without traffic. → While ultrafine PM varied linearly with traffic flow, fine PM was unrelated to flow. → Ultrafine PM decayed exponentially with distance from a cross street with traffic. → The coarse fraction (>2.5 mm) had the greatest intrinsic inflammatory capacity. - Traffic exclusion had variable effects on local particle concentrations and biomarker induction that were inconsistent with the simple expectation that air would be cleaner without traffic.

  9. Simulation Study of a Traffic Light Assistant Based on Vehicle-Infrastructure Communication

    CERN Document Server

    Treiber, Martin

    2014-01-01

    Vehicle-infrastructure communication opens up new ways to improve traffic flow efficiency at signalized intersections. In this study, we assume that equipped vehicles can obtain information about switching times of relevant traffic lights in advance, and additionally counting data from upstream detectors. By means of simulation, we investigate, how equipped vehicles can make use of this information to improve traffic flow. Criteria include cycle-averaged capacity, driving comfort, fuel consumption, travel time, and the number of stops. Depending on the overall traffic demand and the penetration rate of equipped vehicles, we generally find several percent of improvement.

  10. The effect of traffic flows on urban soundscape dynamics and how to analyze it

    OpenAIRE

    Botteldooren, Dick; De Coensel, Bert; Tom, De Muer

    2004-01-01

    Subjective evaluation of soundscapes considers without a doubt the change in amplitude and frequency of the acoustic signal over time. The urban environment can make these soundscape dynamics become rather complex and interesting. In this paper we investigate how traffic flows, quite often the main source of noise in urban an suburban environments, influence the dynamics of the soundscape at intervals of the order of a few seconds to minutes. A model for dynamical traffic noise prediction is ...

  11. 14 CFR 93.311 - Minimum terrain clearance.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Minimum terrain clearance. 93.311 Section 93.311 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Special Flight Rules in the Vicinity of Grand Canyon National Park, AZ §...

  12. Simulation of Genetic Algorithm: Traffic Light Efficiency

    OpenAIRE

    Lienert, Eric

    2015-01-01

    Traffic is a problem in many urban areas worldwide. Traffic flow is dictated by certain devices such as traffic lights. The traffic lights signal when each lane is able to pass through the intersection. Often, static schedules interfere with ideal traffic flow. The purpose of this project was to find a way to make intersections controlled with traffic lights more efficient. This goal was accomplished through the creation of a genetic algorithm, which enhances an input algorithm through geneti...

  13. Cell cycle arrest by a gradient of Dpp signaling during Drosophila eye development

    Directory of Open Access Journals (Sweden)

    Bhattacharya Abhishek

    2010-03-01

    Full Text Available Abstract Background The secreted morphogen Dpp plays important roles in spatial regulation of gene expression and cell cycle progression in the developing Drosophila eye. Dpp signaling is required for timely cell cycle arrest ahead of the morphogenetic furrow as a prelude to differentiation, and is also important for eye disc growth. The dpp gene is expressed at multiple locations in the eye imaginal disc, including the morphogenetic furrow that sweeps across the eye disc as differentiation initiates. Results Studies of Brinker and Dad expression, and of Mad phosphorylation, establish that there is a gradient of Dpp signaling in the eye imaginal disc anterior to the morphogenetic furrow, predominantly in the anterior-posterior axis, and also Dpp signaling at the margins of the disc epithelium and in the dorsal peripodial membrane. Almost all signaling activity seems to spread through the plane of the epithelia, although peripodial epithelium cells can also respond to underlying disc cells. There is a graded requirement for Dpp signaling components for G1 arrest in the eye disc, with more stringent requirements further anteriorly where signaling is lower. The signaling level defines the cell cycle response, because elevated signaling through expression of an activated Thickveins receptor molecule arrested cells at more anterior locations. Very anterior regions of the eye disc were not arrested in response to activated receptor, however, and evidence is presented that expression of the Homothorax protein may contribute to this protection. By contrast to activated Thickveins, ectopic expression of processed Dpp leads to very high levels of Mad phosphorylation which appear to have non-physiological consequences. Conclusions G1 arrest occurs at a threshold level of Dpp signaling within a morphogen gradient in the anterior eye. G1 arrest is specific for one competent domain in the eye disc, allowing Dpp signaling to promote growth at earlier

  14. How can we understand the solar cycle signal on the Earth's surface?

    OpenAIRE

    Kodera, Kunihiko; Thieblemont, Remi; Yukimoto, Seiji; Matthes, Katja

    2016-01-01

    To understand solar cycle signals on the Earth's surface and identify the physical mechanisms responsible, surface temperature variations from observations as well as climate model data are analyzed to characterize their spatial structure. The solar signal in the annual mean surface temperature is characterized by (i) mid-latitude warming and (ii) no warming in the tropics. The mid-latitude warming during solar maxima in both hemispheres is associated with a downward penetration of zonal mean...

  15. Two dimensional mixed traffic flow considering the transit traffic

    Directory of Open Access Journals (Sweden)

    Lingjiang Kong

    2012-12-01

    Full Text Available Based on the two-dimension cellular automaton traffic flow model (BML model, a mixed traffic flow model for urban traffic considering the transit traffic is established in this paper by using the Don't block the box rules. We have investigated the influences of the transit traffic ratio, and found that, in most cases, the urban traffic flow exhibited jam phase. Moreover, focusing on the traffic lights cycle, it is found that the average flow has the periodic fluctuation phenomenon, and we have explained this periodical oscillation change under different boundary conditions. The comparison to practical measured data shows that our stimulation results are accordant with the changes of real traffic flow, which confirms the accuracy and rationality of our model.

  16. A novel insulin receptor-binding protein from Momordica charantia enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin receptor signaling pathway.

    Science.gov (United States)

    Lo, Hsin-Yi; Ho, Tin-Yun; Li, Chia-Cheng; Chen, Jaw-Chyun; Liu, Jau-Jin; Hsiang, Chien-Yun

    2014-09-10

    Diabetes, a common metabolic disorder, is characterized by hyperglycemia. Insulin is the principal mediator of glucose homeostasis. In a previous study, we identified a trypsin inhibitor, named Momordica charantia insulin receptor (IR)-binding protein (mcIRBP) in this study, that might interact with IR. The physical and functional interactions between mcIRBP and IR were clearly analyzed in the present study. Photo-cross-linking coupled with mass spectrometry showed that three regions (17-21, 34-40, and 59-66 residues) located on mcIRBP physically interacted with leucine-rich repeat domain and cysteine-rich region of IR. IR-binding assay showed that the binding behavior of mcIRBP and insulin displayed a cooperative manner. After binding to IR, mcIRBP activated the kinase activity of IR by (5.87 ± 0.45)-fold, increased the amount of phospho-IR protein by (1.31 ± 0.03)-fold, affected phosphoinositide-3-kinase/Akt pathways, and consequently stimulated the uptake of glucose in 3T3-L1 cells by (1.36 ± 0.12)-fold. Intraperitoneal injection of 2.5 nmol/kg mcIRBP significantly decreased the blood glucose levels by 20.9 ± 3.2% and 10.8 ± 3.6% in normal and diabetic mice, respectively. Microarray analysis showed that mcIRBP affected genes involved in insulin signaling transduction pathway in mice. In conclusion, our findings suggest that mcIRBP is a novel IRBP that binds to sites different from the insulin-binding sites on IR and stimulates both the glucose uptake in cells and the glucose clearance in mice. PMID:25144709

  17. The STAR concept: A hierarchical hub-spoke nuclear architecture based on long refuelling interval battery reactors and regional fuel cycle centers

    International Nuclear Information System (INIS)

    The STAR reactor and fuel cycle concept is devised to attain Gen-IV goals by responding to foreseen mid century needs and market conditions. It is targeted to fill energy and potable water needs for urban centres in developing countries and is designed to fit within a hierarchical hub-spoke energy architecture based on regional fuel cycle centres, using nuclear fuel as the long distance energy carrier - with distributed electricity generation as the local carrier to mesh with existing urban energy distribution infrastructures using grid delivery of electricity, potable water, and communications (and sewage return) through a common grid of easements. STAR is also intended for Independent Power Producers in industrialized countries seeking to service emerging markets for hydrogen and water production. STAR concept development is being conducted for a portfolio of specific reactor and balance of plant designs to enable an incremental market penetration that is time-phased according to the degree of R and D required. STAR-LM is a Pb-cooled, 400 MWth, natural circulation reactor of 565 deg. C core outlet temperature driving a supercritical CO2 Brayton cycle for electricity production. It draws on many proven technologies and will be ready for market in 15-20 years. STAR-H2 raises the Pb outlet temperature to 800 deg. C to drive a thermochemical water cracking cycle and will require additional R and D. SSTAR takes the STAR-LM design features down to ∼25 to 50 MWth for secure energy supply to remote small villages. All STAR concepts are designed for 20-year refuelling interval and rely on out-sourcing fuel cycle and waste management services to proposed regional fuel cycle centres. All employ desalination (or alterative) bottoming cycles to extend their scope of energy services and to minimize their environmental footprint. (author)

  18. Traffic flow on realistic road networks with adaptive traffic lights

    CERN Document Server

    de Gier, Jan; Rojas, Omar

    2010-01-01

    We present a model of traffic flow on generic urban road networks based on cellular automata. We apply this model to an existing road network in the Australian city of Melbourne, using empirical data as input. For comparison, we also apply this model to a square-grid network using hypothetical input data. On both networks we compare the effects of non-adative vs adaptive traffic lights, in which instantaneous traffic state information feeds back into the traffic signal schedule. We observe that not only do adaptive traffic lights result in better averages of network observables, they also lead to significantly smaller fluctuations in these observables. We furthermore compare two different systems of adaptive traffic signals, one which is informed by the traffic state on both upstream and downstream links, and one which is informed by upstream links only. We find that, in general, the total travel time is smallest when using the joint upstream-downstream control strategy.

  19. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Li [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China); College of Life Sciences, Hainan Normal University, Haikou, Hainan 571158 (China); Huang, Yong; Du, Qian; Dong, Feng; Zhao, Xiaomin; Zhang, Wenlong; Xu, Xingang [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China); Tong, Dewen, E-mail: dwtong@nwsuaf.edu.cn [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China)

    2014-03-07

    Highlights: • TGEV N protein reduces cell viability by inducing cell cycle arrest and apoptosis. • TGEV N protein induces cell cycle arrest and apoptosis by regulating p53 signaling. • TGEV N protein plays important roles in TGEV-induced cell cycle arrest and apoptosis. - Abstract: Our previous studies showed that TGEV infection could induce cell cycle arrest and apoptosis via activation of p53 signaling in cultured host cells. However, it is unclear which viral gene causes these effects. In this study, we investigated the effects of TGEV nucleocapsid (N) protein on PK-15 cells. We found that TGEV N protein suppressed cell proliferation by causing cell cycle arrest at the S and G2/M phases and apoptosis. Characterization of various cellular proteins that are involved in regulating cell cycle progression demonstrated that the expression of N gene resulted in an accumulation of p53 and p21, which suppressed cyclin B1, cdc2 and cdk2 expression. Moreover, the expression of TGEV N gene promoted translocation of Bax to mitochondria, which in turn caused the release of cytochrome c, followed by activation of caspase-3, resulting in cell apoptosis in the transfected PK-15 cells following cell cycle arrest. Further studies showed that p53 inhibitor attenuated TGEV N protein induced cell cycle arrest at S and G2/M phases and apoptosis through reversing the expression changes of cdc2, cdk2 and cyclin B1 and the translocation changes of Bax and cytochrome c induced by TGEV N protein. Taken together, these results demonstrated that TGEV N protein might play an important role in TGEV infection-induced p53 activation and cell cycle arrest at the S and G2/M phases and apoptosis occurrence.

  20. Optimizing urban traffic control using a rational agent

    Institute of Scientific and Technical Information of China (English)

    Salvador IBARRA-MARTÍNEZ; José A. CASTÁN-ROCHA; Julio LARIA-MENCHACA

    2014-01-01

    This paper is devoted to developing and evaluating a set of technologies with the objective of designing a method-ology for the implementation of sophisticated traffic lights by means of rational agents. These devices would be capable of op-timizing the behavior of a junction with multiple traffic signals, reaching a higher level of autonomy without losing reliability, accuracy, or efficiency in the offered services. In particular, each rational agent in a traffic signal will be able to analyze the requirements and constraints of the road, in order to know its level of demand. With such information, the rational agent will adapt its light cycles with the view of accomplishing more fluid traffic patterns and minimizing the pollutant environmental emissions produced by vehicles while they are stopped at a red light, through using a case-based reasoning (CBR) adaptation. This paper also integrates a microscopic simulator developed to run a set of tests in order to compare the presented methodology with traditional traffic control methods. Two study cases are shown to demonstrate the efficiency of the introduced approach, increasing vehicular mobility and reducing harmful activity for the environment. For instance, in the first scenario, taking into account the studied traffic volumes, our approach increases mobility by 23%and reduces emissions by 35%. When the roads are managed by sophisticated traffic lights, a better level of service and considerable environmental benefits are achieved, demon-strating the utility of the presented approach.

  1. Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus.

    Directory of Open Access Journals (Sweden)

    Franco Folli

    Full Text Available Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM. We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of islet cells. We observed reduced β-cell mass and increased α-cell mass in the Type 2 diabetic pancreas. Confocal microscopy, real-time PCR and western blotting analyses revealed increased expression of PCNA and down-regulation of p27-Kip1 and altered expression of insulin receptors, insulin receptor substrate-2 and phosphorylated BAD. To investigate the mechanisms underlying these findings, we examined a mouse model of insulin resistance in β-cells--which also exhibits reduced β-cell mass, the β-cell-specific insulin receptor knockout (βIRKO. Freshly isolated islets and β-cell lines derived from βIRKO mice exhibited poor cell-cycle progression, nuclear restriction of FoxO1 and reduced expression of cell-cycle proteins favoring growth arrest. Re-expression of insulin receptors in βIRKO β-cells reversed the defects and promoted cell cycle progression and proliferation implying a role for insulin-signaling in β-cell growth. These data provide evidence that human β- and α-cells can enter the cell-cycle, but proliferation of β-cells in T2DM fails due to G1-to-S phase arrest secondary to defective insulin signaling. Activation of insulin signaling, FoxO1 and proteins in β-cell-cycle progression are attractive therapeutic targets to enhance β-cell regeneration in the treatment of T2DM.

  2. MEASURES TO IMPROVE THE TRAFFIC MANAGEMENT

    OpenAIRE

    Дульгер, В.; Пиндюрина, Е.; Муратова, А.

    2012-01-01

    Everybody knows the volume of traffic on today's roads is increasing, thereby, reducing the capacity of the road which causes delays and congestion. "Traffic Management" is the termed as "ways and measures of adjusting, accommodating or adapting the use of road space available without building new ones". The key objective of introducing traffic management measures is to achieve one of the following: improve the flow of traffic, or specific types of traffic (e.g. bus / cycle priority measures)...

  3. Design and Construction of Intelligent Traffic Light Control System Using Fuzzy Logic

    Science.gov (United States)

    Lin, Htin; Aye, Khin Muyar; Tun, Hla Myo; Theingi, Naing, Zaw Min

    2008-10-01

    Vehicular travel is increasing throughout the world, particularly in large urban areas. Therefore the need arises for simulation and optimizing traffic control algorithms to better accommodate this increasing demand. This paper presents a microcontroller simulation of intelligent traffic light controller using fuzzy logic that is used to change the traffic signal cycles adaptively at a two-way intersection. This paper is an attempt to design an intelligent traffic light control systems using microcontrollers such as PIC 16F84A and PIC 16F877A. And then traffic signal can be controlled depending upon the densities of cars behind green and red lights of the two-way intersection by using sensors and detectors circuits.

  4. Traffic engineering eye diagram

    OpenAIRE

    Kowalik, Karol; Collier, Martin

    2005-01-01

    It is said that a picture is worth a thousand words - this statement also applies to networking topics. Thus, to effectively monitor network performance we need tools which present the performance metrics in a graphical way which is also clear and informative. We propose a tool for this purpose which we call the traffic engineering eye diagram (TEED). Eye diagrams are used in digital communications to analyse the quality of a digital signal; the TEED can similarly he used in the traffic engin...

  5. Branched signal wiring of an essential bacterial cell-cycle phosphotransfer protein

    OpenAIRE

    Blair, Jimmy A.; Xu, Qingping; Childers, W. Seth; Mathews, Irimpan I.; Kern, Justin W.; Eckart, Michael; Deacon, Ashley M.; Shapiro, Lucy

    2013-01-01

    Vital to bacterial survival is the faithful propagation of cellular signals, and in Caulobacter crescentus ChpT is an essential mediator within the cell cycle circuit. ChpT functions as a histidine-containing phosphotransfer protein (HPt) that shuttles a phosphoryl group from the receiver domain of CckA, the upstream hybrid histidine kinase (HK), to one of two downstream response regulators (RRs)—CtrA or CpdR—that controls cell cycle progression. To understand how ChpT interacts with multiple...

  6. Impact of local traffic exclusion on near-road air quality: Findings from the New York City 'Summer Streets' campaign

    Energy Technology Data Exchange (ETDEWEB)

    Whitlow, Thomas H., E-mail: thw2@cornell.edu [Department of Horticulture, 23 Plant Science, Cornell University, Ithaca, NY 14853 (United States); Hall, Andrew; Zhang, K. Max [Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853 (United States); Anguita, Juan [Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003 (United States)

    2011-08-15

    We monitored curbside airborne particulate matter (PM) concentrations and its proinflammatory capacity during 3 weekends when vehicle traffic was excluded from Park. Ave., New York City. Fine PM concentration peaked in the morning regardless of traffic while ultrafine PM was 58% lower during mornings without traffic. Ultrafine PM concentration varied linearly with traffic flow, while fine PM spiked sharply in response to random traffic events that were weakly correlated with the traffic signal cycle. Ultrafine PM concentrations decayed exponentially with distance from a cross street with unrestricted traffic flow, reaching background levels within 100 m of the source. IL-6 induction was typically highest on Friday afternoons but showed no clear relationship to the presence of traffic. The coarse fraction (>2.5 {mu}m) had the greatest intrinsic inflammatory capacity, suggesting that coarse PM still warrants attention even as the research focus is shifting to nano-particles. - Highlights: > During a period of traffic exclusion morning PM2.5 concentration remained high. > Ultrafine concentrations were lower during mornings without traffic. > While ultrafine PM varied linearly with traffic flow, fine PM was unrelated to flow. > Ultrafine PM decayed exponentially with distance from a cross street with traffic. > The coarse fraction (>2.5 mm) had the greatest intrinsic inflammatory capacity. - Traffic exclusion had variable effects on local particle concentrations and biomarker induction that were inconsistent with the simple expectation that air would be cleaner without traffic.

  7. Cellular automata cell structure for modeling heterogeneous traffic

    OpenAIRE

    Pal, Dibyendu; C.Mallikarjuna

    2010-01-01

    Gap maintaining behavior significantly affects the traffic flow modeling under heterogeneous traffic conditions. The clearance between two adjacent moving vehicles varies depending on several traffic conditions. From the data collected on the gap maintaining behavior it has been observed that vehicles maintain different gaps when travelling under different traffic conditions and this is also influenced by lateral position of the vehicle. Mallikarjuna (2007) has found that this variable gap ma...

  8. Disrupted G1 to S phase clearance via cyclin signaling impairs liver tissue repair in thioacetamide-treated type 1 diabetic rats

    International Nuclear Information System (INIS)

    Previously we reported that a nonlethal dose of thioacetamide (TA, 300 mg/kg) causes 90% mortality in type 1 diabetic (DB) rats because of irreversible acute liver injury owing to inhibited hepatic tissue repair, primarily due to blockage of G0 to S phase progression of cell division cycle. On the other hand, DB rats receiving 30 mg TA/kg exhibited equal initial liver injury and delayed tissue repair compared to nondiabetic (NDB) rats receiving 300 mg TA/kg, resulting in a delay in recovery from liver injury and survival. The objective of the present study was to test the hypothesis that impaired cyclin-regulated progression of G1 to S phase of the cell cycle may explain inhibited liver tissue repair, hepatic failure, and death, contrasted with delayed liver tissue repair but survival observed in the DB rats receiving 300 in contrast to 30 mg TA/kg. In the TA-treated NDB rats sustained MAPKs and cyclin expression resulted in higher phosphorylation of retinoblastoma (pRb), explaining prompt tissue repair and survival. In contrast, DB rats receiving the same dose of TA (300 mg/kg) exhibited suppressed MAPKs and cyclin expression that led to inhibition of pRb, inhibited tissue repair, and death. On the other hand, DB rats receiving 30 mg TA/kg exhibited delayed up regulation of MAPK signaling that delayed the expression of CD1 and pRb, explaining delayed stimulation of tissue repair observed in this group. In conclusion, the hepatotoxicant TA has a dose-dependent adverse effect on cyclin-regulated pRb signaling: the lower dose causes a recoverable delay, whereas the higher dose inhibits it with corresponding effect on the ultimate outcomes on hepatic tissue repair; this dose-dependent adverse effect is substantially shifted to the left of the dose response curve in diabetes

  9. Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis.

    Directory of Open Access Journals (Sweden)

    Hsien-Yi Lin

    Full Text Available BACKGROUND: Notch signaling involves ligand-receptor interactions through direct cell-cell contact. Multiple Notch receptors and ligands are expressed in the epidermis and hair follicles during embryonic development and the adult stage. Although Notch signaling plays an important role in regulating differentiation of the epidermis and hair follicles, it remains unclear how Notch signaling participates in late-stage epidermal differentiation and postnatal hair cycle homeostasis. METHODOLOGY AND PRINCIPAL FINDINGS: We applied Cre/loxP system to generate conditional gene targeted mice that allow inactivation of critical components of Notch signaling pathway in the skin. Rbpj, the core component of all four Notch receptors, and Pofut1, an essential factor for ligand-receptor interactions, were inactivated in hair follicle lineages and suprabasal layer of the epidermis using the Tgfb3-Cre mouse line. Rbpj conditional inactivation resulted in granular parakeratosis and reactive epidermal hyperplasia. Pofut1 conditional inactivation led to ultrastructural abnormalities in the granular layer and altered filaggrin processing in the epidermis, suggesting a perturbation of the granular layer differentiation. Disruption of Pofut1 in hair follicle lineages resulted in aberrant telogen morphology, a decrease of bulge stem cell markers, and a concomitant increase of K14-positive keratinocytes in the isthmus of mutant hair follicles. Pofut1-deficent hair follicles displayed a delay in anagen re-entry and dysregulation of proliferation and apoptosis during the hair cycle transition. Moreover, increased DNA double stand breaks were detected in Pofut1-deficent hair follicles, and real time PCR analyses on bulge keratinocytes isolated by FACS revealed an induction of DNA damage response and a paucity of DNA repair machinery in mutant bulge keratinocytes. SIGNIFICANCE: our data reveal a role for Notch signaling in regulating late-stage epidermal differentiation

  10. Are signalized intersections with cycle tracks safer? A case-control study based on automated surrogate safety analysis using video data.

    Science.gov (United States)

    Zangenehpour, Sohail; Strauss, Jillian; Miranda-Moreno, Luis F; Saunier, Nicolas

    2016-01-01

    Cities in North America have been building bicycle infrastructure, in particular cycle tracks, with the intention of promoting urban cycling and improving cyclist safety. These facilities have been built and expanded but very little research has been done to investigate the safety impacts of cycle tracks, in particular at intersections, where cyclists interact with turning motor-vehicles. Some safety research has looked at injury data and most have reached the conclusion that cycle tracks have positive effects of cyclist safety. The objective of this work is to investigate the safety effects of cycle tracks at signalized intersections using a case-control study. For this purpose, a video-based method is proposed for analyzing the post-encroachment time as a surrogate measure of the severity of the interactions between cyclists and turning vehicles travelling in the same direction. Using the city of Montreal as the case study, a sample of intersections with and without cycle tracks on the right and left sides of the road were carefully selected accounting for intersection geometry and traffic volumes. More than 90h of video were collected from 23 intersections and processed to obtain cyclist and motor-vehicle trajectories and interactions. After cyclist and motor-vehicle interactions were defined, ordered logit models with random effects were developed to evaluate the safety effects of cycle tracks at intersections. Based on the extracted data from the recorded videos, it was found that intersection approaches with cycle tracks on the right are safer than intersection approaches with no cycle track. However, intersections with cycle tracks on the left compared to no cycle tracks seem to be significantly safer. Results also identify that the likelihood of a cyclist being involved in a dangerous interaction increases with increasing turning vehicle flow and decreases as the size of the cyclist group arriving at the intersection increases. The results highlight the

  11. TRAFFIC RETIMING SYSTEM USING IMAGE PROCESSING

    OpenAIRE

    Tanmayi Jain*

    2015-01-01

    One of the main problems in cities is traffic, this paper proposed new solution to traffic control. The main design concept of this project is to control the traffic automatically. System is made more efficient with addition of intelligence in term of artificial vision, using image processing techniques to estimate actual road traffic and compute time, each time for every road before enabling the signal. This model is resemblance of traditional traffic police man who takes better ...

  12. Formation and Propagation of Local Traffic Jam

    OpenAIRE

    Hong-sheng Qi; Dian-hai Wang; Peng Chen

    2013-01-01

    Large scale traffic congestion often stems from local traffic jam in single road or intersection. In this paper, macroscopic method was used to explore the formation and propagation of local traffic jam. It is found that (1) the propagation of traffic jam can be seen as the propagation of traffic signal parameters, that is, virtual split and virtual green time; (2) for a road with endogenous flow, entrance location influences the jam propagation. With the same demand (upstream links flow and ...

  13. Impact of steroid hormone signals on Drosophila cell cycle during development

    Directory of Open Access Journals (Sweden)

    Quinn Leonie

    2009-01-01

    Full Text Available Abstract Metamorphosis of Drosophila involves proliferation, differentiation and death of larval tissues in order to form the adult fly. The major steroid hormone implicated in the larval-pupal transition and adult tissue modelling is ecdysone. Previous reviews have draw together studies connecting ecdysone signaling to the processes of apoptosis and differentiation. Here we discuss those reports connecting the ecdysone pulse to developmentally regulated cell cycle progression.

  14. Clustering in Cell Cycle Dynamics with General Response/Signaling Feedback

    CERN Document Server

    Young, Todd; Buckalew, Richard; Moses, Gregory; Boczko, Erik; 10.1016/j.jtbi.2011.10.002.

    2011-01-01

    Motivated by experimental and theoretical work on autonomous oscillations in yeast, we analyze ordinary differential equations models of large populations of cells with cell-cycle dependent feedback. We assume a particular type of feedback that we call Responsive/Signaling (RS), but do not specify a functional form of the feedback. We study the dynamics and emergent behaviour of solutions, particularly temporal clustering and stability of clustered solutions. We establish the existence of certain periodic clustered solutions as well as "uniform" solutions and add to the evidence that cell-cycle dependent feedback robustly leads to cell-cycle clustering. We highlight the fundamental differences in dynamics between systems with negative and positive feedback. For positive feedback systems the most important mechanism seems to be the stability of individual isolated clusters. On the other hand we find that in negative feedback systems, clusters must interact with each other to reinforce coherence. We conclude fr...

  15. Web traffic and firm performance

    DEFF Research Database (Denmark)

    Farooq, Omar; Aguenaou, Samir

    2013-01-01

    Does the traffic generated by websites of firms signal anything to stock market participants? Does higher web-traffic translate into availability of more information and therefore lower agency problems? And if answers to above questions are in affirmative, does higher web-traffic traffic translate...... into better firm performance? This paper aims to answer these questions by documenting a positive relationship between the extent of web-traffic and firm performance in the MENA region during the 2010. We argue that higher web-traffic lowers the agency problems in firms by disseminating more information...... to stock market participants. Consequently, lower agency problems translate into better performance. Furthermore, we also show that agency reducing role of web-traffic is more pronounced in regimes where information environment is already bad. For example, our results show stronger impact of web...

  16. Organic traffic control

    OpenAIRE

    Prothmann, Holger

    2011-01-01

    Modern cities cannot be imagined without traffic lights controlling the road network. To handle the network's changing demands efficiently, the signal plan specification needs to be shifted from the design time to the run-time of a signal system. The generic observer/controller architecture proposed for Organic Computing facilitates this shift. A two-levelled learning mechanism optimises signal plans on-line while a distributed coordination mechanism establishes green waves in the road network.

  17. Physics of traffic gridlock in a city

    OpenAIRE

    Kerner, Boris S.

    2011-01-01

    Based of simulations of a stochastic three-phase traffic flow model, we reveal that at a signalized city intersection under small link inflow rates at which a vehicle queue developed during the red phase of light signal dissolves fully during the green phase, i.e., no traffic gridlock should be expected, nevertheless, traffic breakdown with the subsequent city gridlock occurs with some probability after a random time delay. This traffic breakdown is initiated by a first-order phase transition...

  18. Use of Data Comm by Flight Crew to Conduct Interval Management Operations to Parallel Dependent Runways

    Science.gov (United States)

    Baxley, Brian T.; Hubbs, Clay; Shay, Rick; Karanian, James

    2011-01-01

    The Interval Management (IM) concept is being developed as a method to maintain or increase high traffic density airport arrival throughput while allowing aircraft to conduct near idle thrust descents. The Interval Management with Spacing to Parallel Dependent Runways (IMSPiDR1) experiment at NASA Langley Research Center used 24 commercial pilots to examine IM procedures to conduct parallel dependent runway arrival operations while maintaining safe but efficient intervals behind the preceding aircraft. The use of IM procedures during these operations requires a lengthy and complex clearance from Air Traffic Control (ATC) to the participating aircraft, thereby making the use of Controller Pilot Data Link Communications (CPDLC) highly desirable as the communication method. The use of CPDLC reduces the need for voice transmissions between controllers and flight crew, and enables automated transfer of IM clearance elements into flight management systems or other aircraft avionics. The result is reduced crew workload and an increase in the efficiency of crew procedures. This paper focuses on the subset of data collected related to the use of CPDLC for IM operations into a busy airport. Overall, the experiment and results were very successful, with the mean time under 43 seconds for the flight crew to load the clearance into the IM spacing tool, review the calculated speed, and respond to ATC. An overall mean rating of Moderately Agree was given when the crews were asked if the use of CPDLC was operationally acceptable as simulated in this experiment. Approximately half of the flight crew reported the use of CPDLC below 10,000 for IM operations was unacceptable, with 83% reporting below 5000 was unacceptable. Also described are proposed modifications to the IM operations that may reduce CPDLC Respond time to less than 30 seconds and should significantly reduce the complexity of crew procedures, as well as follow-on research issues for operational use of CPDLC during IM

  19. High intensity interval and moderate continuous cycle training in a physical education programme improves health-related fitness in young females.

    Science.gov (United States)

    Mazurek, K; Zmijewski, P; Krawczyk, K; Czajkowska, A; Kęska, A; Kapuściński, P; Mazurek, T

    2016-06-01

    The aim of the study was to investigate the effects of eight weeks of regular physical education classes supplemented with high intensity interval cycle exercise (HIIE) or continuous cycle exercises of moderate intensity (CME). Forty-eight collegiate females exercising in two regular physical education classes per week were randomly assigned to two programmes (HIIE; n = 24 or CME; n = 24) of additional (one session of 63 minutes per week) physical activity for 8 weeks. Participants performed HIIE comprising 2 series of 6x10 s sprinting with maximal pedalling cadence and active recovery pedalling with intensity 65%-75% HRmax or performed CME corresponding to 65%-75% HRmax. Before and after the 8-week programmes, anthropometric data and aero- and anaerobic capacity were measured. Two-way ANOVA revealed a significant time main effect for VO2max (p aerobic and anaerobic capacity in collegiate females. Eight weeks of regular physical education classes supplemented with CME sessions are more effective in improving body composition than physical education classes supplemented with HIIE sessions. In contrast to earlier, smaller trials, similar improvements in aerobic capacity were observed following physical activity with additional HIIE or CME sessions. PMID:27274106

  20. Robust Adaptive Beamforming for Multiple Signals of Interest with Cycle Frequency Error

    Directory of Open Access Journals (Sweden)

    Huang Chia-Cheng

    2010-01-01

    Full Text Available This paper deals with the problem of robust adaptive array beamforming by exploiting the signal cyclostationarity. Recently, a novel cyclostationarity-exploiting beamforming method has been proposed by J.-H. Lee and C.-C. Huang (2009 for dealing with the situation of multiple signals of interest (SOI based on the LS-SCORE algorithm. This method is referred to as the multiple LS-SCORE (MLS-SCORE algorithm. However, the MLS-SCORE algorithm suffers from severe performance degradation even if there is a small mismatch in the cycle frequencies of the SOIs. In this paper, we evaluate the performance of the MLS-SCORE algorithm in the presence of cycle frequency error (CFE. The output SINR of an adaptive beamforming using the MLS-SCORE algorithm deteriorates like a function as the number of data snapshots increases. To tackle this difficulty, we present an efficient method to find an appropriate estimate for each of the cycle frequencies of the SOIs iteratively to achieve robust adaptive beamforming against the CFE. Simulation results for showing the effectiveness of the proposed method are provided.

  1. Extracting the respiration cycle lengths from ECG signal recorded with bed sheet electrodes

    Science.gov (United States)

    Vehkaoja, A.; Peltokangas, M.; Lekkala, J.

    2013-09-01

    A method for recognizing the respiration cycle lengths from the electrocardiographic (ECG) signal recorded with textile electrodes that are attached to a bed sheet is proposed. The method uses two features extracted from the ECG that are affected by the respiration: respiratory sinus arrhythmia and the amplitude of the R-peaks. The proposed method was tested in one hour long recordings with ten healthy young adults. A relative mean absolute error of 5.6 % was achieved when the algorithm was able to provide a result for approximately 40 % of the time. 90 % of the values were within 0.5 s and 97 % within 1 s from the reference respiration value. In addition to the instantaneous respiration cycle lengths, also the mean values during 1 and 5 minutes epochs are calculated. The effect of the ECG signal source is evaluated by calculating the result also from the simultaneously recorded reference ECG signal. The acquired respiration information can be used in the estimation of sleep quality and the detection of sleep disorders.

  2. Exploration of trade-offs between steady-state and dynamic properties in signaling cycles

    International Nuclear Information System (INIS)

    In the intracellular signaling networks that regulate important cell processes, the base pattern comprises the cycle of reversible phosphorylation of a protein, catalyzed by kinases and opposing phosphatases. Mathematical modeling and analysis have been used for gaining a better understanding of their functions and to capture the rules governing system behavior. Since biochemical parameters in signaling pathways are not easily accessible experimentally, it is necessary to explore possibilities for both steady-state and dynamic responses in these systems. While a number of studies have focused on analyzing these properties separately, it is necessary to take into account both of these responses simultaneously in order to be able to interpret a broader range of phenotypes. This paper investigates the trade-offs between optimal characteristics of both steady-state and dynamic responses. Following an inverse sensitivity analysis approach, we use systematic optimization methods to find the biochemical and biophysical parameters that simultaneously achieve optimal steady-state and dynamic performance. Remarkably, we find that even a single covalent modification cycle can simultaneously and robustly achieve high ultrasensitivity, high amplification and rapid signal transduction. We also find that the response rise and decay times can be modulated independently by varying the activating- and deactivating-enzyme-to-interconvertible-protein ratios. (paper)

  3. Extracting the respiration cycle lengths from ECG signal recorded with bed sheet electrodes

    International Nuclear Information System (INIS)

    A method for recognizing the respiration cycle lengths from the electrocardiographic (ECG) signal recorded with textile electrodes that are attached to a bed sheet is proposed. The method uses two features extracted from the ECG that are affected by the respiration: respiratory sinus arrhythmia and the amplitude of the R-peaks. The proposed method was tested in one hour long recordings with ten healthy young adults. A relative mean absolute error of 5.6 % was achieved when the algorithm was able to provide a result for approximately 40 % of the time. 90 % of the values were within 0.5 s and 97 % within 1 s from the reference respiration value. In addition to the instantaneous respiration cycle lengths, also the mean values during 1 and 5 minutes epochs are calculated. The effect of the ECG signal source is evaluated by calculating the result also from the simultaneously recorded reference ECG signal. The acquired respiration information can be used in the estimation of sleep quality and the detection of sleep disorders

  4. Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle.

    Science.gov (United States)

    Dupont, Joëlle; Scaramuzzi, Rex J

    2016-06-01

    Data derived principally from peripheral tissues (fat, muscle and liver) show that insulin signals via diverse interconnecting intracellular pathways and that some of the major intersecting points (known as critical nodes) are the IRSs (insulin receptor substrates), PI3K (phosphoinositide kinase)/Akt and MAPK (mitogen-activated protein kinase). Most of these insulin pathways are probably also active in the ovary and their ability to interact with each other and also with follicle-stimulating hormone (FSH) and luteinizing hormone (LH) signalling pathways enables insulin to exert direct modulating influences on ovarian function. The present paper reviews the intracellular actions of insulin and the uptake of glucose by ovarian tissues (granulosa, theca and oocyte) during the oestrous/menstrual cycle of some rodent, primate and ruminant species. Insulin signals through diverse pathways and these are discussed with specific reference to follicular cell types (granulosa, theca and oocyte). The signalling pathways for FSH in granulosa cells and LH in granulosa and theca cells are summarized. The roles of glucose and of insulin-mediated uptake of glucose in folliculogenesis are discussed. It is suggested that glucose in addition to its well-established role of providing energy for cellular function may also have insulin-mediated signalling functions in ovarian cells, involving AMPK (AMP-dependent protein kinase) and/or hexosamine. Potential interactions of insulin signalling with FSH or LH signalling at critical nodes are identified and the available evidence for such interactions in ovarian cells is discussed. Finally the action of the insulin-sensitizing drugs metformin and the thiazolidinedione rosiglitazone on follicular cells is reviewed. PMID:27234585

  5. Intelligent Ambulance Traffic Assistance System

    Directory of Open Access Journals (Sweden)

    RONOJOY GHOSH

    2013-09-01

    Full Text Available With the increase in traffic road density, several causalities occur due to delay in taking a patient to the hospital in an ambulance. In this paper, we have developed an algorithm to find the shortest path to reach the required destination. As required the software will identify the present location of the vehicle and ask the user for the destination. Then it will show all the available paths, highlighting the shortest one or in several cases the most optimum one. Further we made the traffic signals automated for special vehicles like an ambulance or a fire-engine such that the signals will go green for the ambulance as it comes in the vicinity of the traffic signal, thus providing them with a clear path to reach its destination. The original signal is restored as soon as the ambulance goes undetected by the Bluetooth scanner of the traffic signal.

  6. An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification.

    Science.gov (United States)

    Wang, Ding; Yuan, Yali; Zheng, Yingning; Chai, Yaqin; Yuan, Ruo

    2016-05-21

    In this work, an electrochemical peptide biosensor was developed for matrix metalloproteinase-2 (MMP-2) detection by conversion of a peptide cleavage event into DNA detection with exonuclease III (Exo III)-assisted cycling signal amplification. PMID:27054357

  7. Renal clearance of melatonin

    OpenAIRE

    Editorial Office

    1996-01-01

    Only two publications exist in which actual values for the renal clearance of intact melatonin in man is described. The melatonin clearance values were, however, obtained either after the oral intake of melatonin, or by applying different techniques for the determination of melatonin in urine and plasma. In this study, renal clearance of melatonin was determined during the hours where melatonin concentrations are relatively constant. Melatonin levels in plasma and urine respectively were e...

  8. The parasite clearance curve

    OpenAIRE

    White NJ

    2011-01-01

    Abstract Parasite clearance rates are important measures of anti-malarial drug efficacy. They are particularly important in the assessment of artemisinin resistance. The slope of the log-linear segment in the middle of the parasite clearance curve has the least inter-individual variance and is the focus of therapeutic assessment. The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed.

  9. The Effect of High-Intensity Interval Cycling Sprints Subsequent to Arm-Curl Exercise on Upper-Body Muscle Strength and Hypertrophy.

    Science.gov (United States)

    Kikuchi, Naoki; Yoshida, Shou; Okuyama, Mizuki; Nakazato, Koichi

    2016-08-01

    Kikuchi, N, Yoshida, S, Okuyama, M, and Nakazato, K. The effect of high-intensity interval cycling sprints subsequent to arm-curl exercise on upper-body muscle strength and hypertrophy. J Strength Cond Res 30(8): 2318-2323, 2016-The purpose of this study was to examine whether lower limb sprint interval training (SIT) after arm resistance training (RT) influences training response of arm muscle strength and hypertrophy. Twenty men participated in this study. We divided subjects into RT group (n = 6) and concurrent training group (CT, n = 6). The RT program was designed to induce muscular hypertrophy (3 sets × 10 repetitions [reps] at 80% 1 repetition maximum [1RM] of arm-curl exercise) and was performed in an 8-week training schedule performed 3 times per week on nonconsecutive days. Subjects assigned to the CT group performed identical protocols as strength training and modified SIT (4 sets of 30-s maximal effort, separated in 4 m 30-s rest intervals) on the same day. Pretest and posttest maximal oxygen consumption (V[Combining Dot Above]O2max), muscle cross-sectional area (CSA), and 1RM were measured. Significant increase in V[Combining Dot Above]O2max from pretest to posttest was observed in the CT group (p = 0.010, effect size [ES] = 1.84) but not in the RT group (p = 0.559, ES = 0.35). Significant increase in CSA from pretest to posttest was observed in the RT group (p = 0.030, ES = 1.49) but not in the CT group (p = 0.110, ES = 1.01). Significant increase in 1RM from pretest to posttest was observed in the RT group (p = 0.021, ES = 1.57) but not in the CT group (p = 0.065, ES = 1.19). In conclusion, our data indicate that concurrent lower limb SIT interferes with arm muscle hypertrophy and strength. PMID:26694501

  10. Programming with Intervals

    Science.gov (United States)

    Matsakis, Nicholas D.; Gross, Thomas R.

    Intervals are a new, higher-level primitive for parallel programming with which programmers directly construct the program schedule. Programs using intervals can be statically analyzed to ensure that they do not deadlock or contain data races. In this paper, we demonstrate the flexibility of intervals by showing how to use them to emulate common parallel control-flow constructs like barriers and signals, as well as higher-level patterns such as bounded-buffer producer-consumer. We have implemented intervals as a publicly available library for Java and Scala.

  11. Direct measurement of first-pass ileal clearance of a bile acid in humans

    International Nuclear Information System (INIS)

    The purpose of this study was to develop and validate a method of directly measuring ileal bile acid absorption efficiency during a single enterohepatic cycle (first-pass ileal clearance). This has become feasible for the first time because of the availability of the synthetic gamma-labeled bile acid 75Selena-homocholic acid-taurine (75SeHCAT). Together with the corresponding natural bile acid cholic acid-taurine (labeled with 14C), SeHCAT was infused distal to an occluding balloon situated beyond the ampulla of Vater in six healthy subjects. Completion of a single enterohepatic cycle was assessed by obtaining a plateau for 75SeHCAT activity proximal to the occluding balloon, which prevented further cycles. Unabsorbed 75SeHCAT was collected after total gut washout, which was administered distal to the occluding balloon. 75SeHCAT activity in the rectal effluent measured by gamma counter was compared with that of absorbed 75SeHCAT level measured by gamma camera and was used to calculate first-pass ileal clearance. This was very efficient (mean value, 96%) and showed very little variation in the six subjects studied (range, 95%-97%). A parallel time-activity course in hepatic bile for 14C and 75Se during a single enterohepatic cycle, together with a ratio of unity for 14C/75Se in samples obtained at different time intervals, suggests that 75SeHCAT is handled by the ileum like the natural bile acid cholic acid-taurine. Extrapolation of 75SeHCAT first-pass ileal clearance to that of the natural bile acid therefore seems justifiable. In a subsidiary experiment, ileal absorption efficiency per day for 75SeHCAT was also measured by scanning the gallbladder area on 5 successive days after the measurement of first-pass ileal clearance. In contrast with absorption efficiency per cycle, absorption efficiency per day varied widely (49%-86%)

  12. Security Clearance Tracking System

    Data.gov (United States)

    National Archives and Records Administration — SCTS supports the adjudication process of private background investigations and clearances for potential employees, contractors, interns and student workers.

  13. Noninvasive clearance of airway secretions.

    Science.gov (United States)

    Hardy, K A; Anderson, B D

    1996-06-01

    Airway clearance techniques are indicated for specific diseases that have known clearance abnormalities (Table 2). Murray and others have commented that such techniques are required only for patients with a daily sputum production of greater than 30 mL. The authors have observed that patients with diseases known to cause clearance abnormalities can have sputum clearance with some techniques, such as positive expiratory pressure, autogenic drainage, and active cycle of breathing techniques, when PDPV has not been effective. Hasani et al has shown that use of the forced exhalatory technique in patients with nonproductive cough still resulted in movement of secretions proximally from all regions of the lung in patients with airway obstruction. It is therefore reasonable to consider airway clearance techniques for any patient who has a disease known to alter mucous clearance, including CF, dyskinetic cilia syndromes, and bronchiectasis from any cause. Patients with atelectasis from mucous plugs and hypersecretory states, such as asthma and chronic bronchitis, patients with pain secondary to surgical procedures, and patients with neuromuscular disease, weak cough, and abnormal patency of the airway may also benefit from the application of airway clearance techniques. Infants and children up to 3 years of age with airway clearance problems need to be treated with PDPV. Manual percussion with hands alone or a flexible face mask or cup and small mechanical vibrator/percussors, such as the ultrasonic devices, can be used. The intrapulmonary percussive ventilator shows growing promise in this area. The high-frequency oscillator is not supplied with vests of appropriate sizes for tiny babies and has not been studied in this group. Young patients with neuromuscular disease may require assisted ventilation and airway oscillations can be applied. CPAP alone has been shown to improve achievable flow rates that will increase air-liquid interactions for patients with these diseases

  14. Temporal Statistic of Traffic Accidents in Turkey

    Science.gov (United States)

    Erdogan, S.; Yalcin, M.; Yilmaz, M.; Korkmaz Takim, A.

    2015-10-01

    Traffic accidents form clusters in terms of geographic space and over time which themselves exhibit distinct spatial and temporal patterns. There is an imperative need to understand how, where and when traffic accidents occur in order to develop appropriate accident reduction strategies. An improved understanding of the location, time and reasons for traffic accidents makes a significant contribution to preventing them. Traffic accident occurrences have been extensively studied from different spatial and temporal points of view using a variety of methodological approaches. In literature, less research has been dedicated to the temporal patterns of traffic accidents. In this paper, the numbers of traffic accidents are normalized according to the traffic volume and the distribution and fluctuation of these accidents is examined in terms of Islamic time intervals. The daily activities and worship of Muslims are arranged according to these time intervals that are spaced fairly throughout the day according to the position of the sun. The Islamic time intervals are never been used before to identify the critical hour for traffic accidents in the world. The results show that the sunrise is the critical time that acts as a threshold in the rate of traffic accidents throughout Turkey in Islamic time intervals.

  15. Cycling excitation process: An ultra efficient and quiet signal amplification mechanism in semiconductor

    International Nuclear Information System (INIS)

    Signal amplification, performed by transistor amplifiers with its merit rated by the efficiency and noise characteristics, is ubiquitous in all electronic systems. Because of transistor thermal noise, an intrinsic signal amplification mechanism, impact ionization was sought after to complement the limits of transistor amplifiers. However, due to the high operation voltage (30-200 V typically), low power efficiency, limited scalability, and, above all, rapidly increasing excess noise with amplification factor, impact ionization has been out of favor for most electronic systems except for a few applications such as avalanche photodetectors and single-photon Geiger detectors. Here, we report an internal signal amplification mechanism based on the principle of the phonon-assisted cycling excitation process (CEP). Si devices using this concept show ultrahigh gain, low operation voltage, CMOS compatibility, and, above all, quantum limit noise performance that is 30 times lower than devices using impact ionization. Established on a unique physical effect of attractive properties, CEP-based devices can potentially revolutionize the fields of semiconductor electronics

  16. Cycling excitation process: An ultra efficient and quiet signal amplification mechanism in semiconductor

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Yu-Hsin [Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0418 (United States); Yan, Lujiang; Zhang, Alex Ce; Hall, David; Niaz, Iftikhar Ahmad; Zhou, Yuchun [Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0409 (United States); Sham, L. J. [Department of Physics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 (United States); Lo, Yu-Hwa, E-mail: ylo@ucsd.edu [Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0418 (United States); Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0409 (United States)

    2015-08-03

    Signal amplification, performed by transistor amplifiers with its merit rated by the efficiency and noise characteristics, is ubiquitous in all electronic systems. Because of transistor thermal noise, an intrinsic signal amplification mechanism, impact ionization was sought after to complement the limits of transistor amplifiers. However, due to the high operation voltage (30-200 V typically), low power efficiency, limited scalability, and, above all, rapidly increasing excess noise with amplification factor, impact ionization has been out of favor for most electronic systems except for a few applications such as avalanche photodetectors and single-photon Geiger detectors. Here, we report an internal signal amplification mechanism based on the principle of the phonon-assisted cycling excitation process (CEP). Si devices using this concept show ultrahigh gain, low operation voltage, CMOS compatibility, and, above all, quantum limit noise performance that is 30 times lower than devices using impact ionization. Established on a unique physical effect of attractive properties, CEP-based devices can potentially revolutionize the fields of semiconductor electronics.

  17. Calculating Clearances for Manipulators

    Science.gov (United States)

    Copeland, E. L.; Peticolas, J. D.; Ray, L. D.

    1983-01-01

    Set of algorithms rapidly calculates minimum safe clearances for remote manipulators. Such calculations are used in design of trajectories for manipulators to ensure they do not accidentally strike surrounding objects. Structural parts are considered as cylindrical shells having circular plane areas for ends. Clearance calculation method offers special benefits in industrial robotics, particularly in automated machining.

  18. Revolutionizing Technology Prioritizing Emergency Vehicles in Traffic

    OpenAIRE

    B. Ramya Sundaram; E. Aravind; S. Harithaa; G. Karthick; Shriram K. Vasudevan

    2014-01-01

    The following study brings to the fore a technology exclusively engineered to eradicate the snags and inadequacies persisting in the existing system of traffic control and thus aims to provide a sophisticated operation and uninterrupted course for the emergency vehicles. The traffic in Indian roads has shown a tremendous rise over the years and the conventional pre-timed traffic signals and frequent traffic congestions, delaying the road commuters, have led to outrage and chaos on several occ...

  19. Interval Training.

    Science.gov (United States)

    President's Council on Physical Fitness and Sports, Washington, DC.

    Regardless of the type of physical activity used, interval training is simply repeated periods of physical stress interspersed with recovery periods during which activity of a reduced intensity is performed. During the recovery periods, the individual usually keeps moving and does not completely recover before the next exercise interval (e.g.,…

  20. Automatic and efficient driving strategies while approaching a traffic light

    CERN Document Server

    Treiber, Martin

    2014-01-01

    Vehicle-infrastructure communication opens up new ways to improve traffic flow efficiency at signalized intersections. In this study, we assume that equipped vehicles can obtain information about switching times of relevant traffic lights in advance. This information is used to improve traffic flow by the strategies 'early braking', 'anticipative start', and 'flying start'. The strategies can be implemented in driver-information mode, or in automatic mode by an Adaptive Cruise Controller (ACC). Quality criteria include cycle-averaged capacity, driving comfort, fuel consumption, travel time, and the number of stops. By means of simulation, we investigate the isolated strategies and the complex interactions between the strategies and between equipped and non-equipped vehicles. As universal approach to assess equipment level effects we propose relative performance indexes and found, at a maximum speed of 50 km/h, improvements of about 15% for the number of stops and about 4% for the other criteria. All figures d...

  1. Self——adaptive Control Method for Traffic Signal at Single Intersection Based on Cloud Model Adaptive%基于云模型的单路口交通信号自适应控制方法研究

    Institute of Scientific and Technical Information of China (English)

    刘罗仁; 罗金玲

    2011-01-01

    为了减少车辆通过路口的延误,提出了一种基于云模型的单路口交通信号自适应控制方法;使用云模型作为信号控制的基础模型,利用云模型中的正态云发生器和前件云发生器算法分别对道路交通信息进行处理并产生自适应的控制规则,以实现单路口交通信号的自适应控制;通过仿真实验,结果表明,使用云模型作为控制方法,比较传统控制方式更具智能化,更接近于人脑思维过程的控制方法,这也是将来交通信号控制的发展方向.%In order to reduce traffic delays through the intersection, this paper presents, a single intersection based on cloud model adaptive traffic signal control. Signal control using the cloud model as the basis model, the cloud model in the normal cloud generator and the former pieces of cloud generator algorithms are processed on road traffic information and generates adaptive control rules in order to achieve a single self-intersection traffic signal adaptive control. The simulation experiment results show that the control method using the cloud model as the more traditional control method is more intelligent, more close to the brain control the process of thinking, this is the future direction of development of traffic signal control.

  2. Isothermal cycling and cascade signal amplification strategy for ultrasensitive colorimetric detection of nucleic acids

    International Nuclear Information System (INIS)

    We have designed a novel isothermal cascade signal-amplification strategy for ultrasensitive colorimetric determination of nucleic acids. It is based on double-cycling amplification with formation of DNAzyme via a polymerase-induced strand-displacement reaction and nicking endonuclease-assisted recycling. The assay makes use of a hairpin DNA, a short primer, KF-polymerase, and nicking endonuclease. The presence of a target DNA triggers the strand-displacement and polymerization reaction with the formation of numerous DNAzyme molecules. Upon addition of H2O2 to the resulting mixture, the H2O2 reacts with 2,2′-azino-bis (3-ethylbenzothiozoline)-6-sulfonate to form a colored product in the aid of DNAzyme, which is quantified by photometry at 415 nm. Under optimal conditions, the assay allows target DNA to be determined at concentration as low as 0.6 aM. (author)

  3. Vehicular headways on signalized intersections: theory, models, and reality

    Science.gov (United States)

    Krbálek, Milan; Šleis, Jiří

    2015-01-01

    We discuss statistical properties of vehicular headways measured on signalized crossroads. On the basis of mathematical approaches, we formulate theoretical and empirically inspired criteria for the acceptability of theoretical headway distributions. Sequentially, the multifarious families of statistical distributions (commonly used to fit real-road headway statistics) are confronted with these criteria, and with original empirical time clearances gauged among neighboring vehicles leaving signal-controlled crossroads after a green signal appears. Using three different numerical schemes, we demonstrate that an arrangement of vehicles on an intersection is a consequence of the general stochastic nature of queueing systems, rather than a consequence of traffic rules, driver estimation processes, or decision-making procedures.

  4. Simulations of Continuous Descent Operations with Arrival-management Automation and Mixed Flight-deck Interval Management Equipage

    Science.gov (United States)

    Callantine, Todd J.; Kupfer, Michael; Martin, Lynne Hazel; Prevot, Thomas

    2013-01-01

    Air traffic management simulations conducted in the Airspace Operations Laboratory at NASA Ames Research Center have addressed the integration of trajectory-based arrival-management automation, controller tools, and Flight-Deck Interval Management avionics to enable Continuous Descent Operations (CDOs) during periods of sustained high traffic demand. The simulations are devoted to maturing the integrated system for field demonstration, and refining the controller tools, clearance phraseology, and procedures specified in the associated concept of operations. The results indicate a variety of factors impact the concept's safety and viability from a controller's perspective, including en-route preconditioning of arrival flows, useable clearance phraseology, and the characteristics of airspace, routes, and traffic-management methods in use at a particular site. Clear understanding of automation behavior and required shifts in roles and responsibilities is important for controller acceptance and realizing potential benefits. This paper discusses the simulations, drawing parallels with results from related European efforts. The most recent study found en-route controllers can effectively precondition arrival flows, which significantly improved route conformance during CDOs. Controllers found the tools acceptable, in line with previous studies.

  5. Speed-Flow Analysis for Interrupted Oversaturated Traffic Flow with Heterogeneous Structure for Urban Roads

    Directory of Open Access Journals (Sweden)

    Hemant Kumar Sharma

    2012-06-01

    Full Text Available Speed–flow functions have been developed by several transportation experts to predict accurately the speed of urban road network. HCM Speed-Flow Curve, BPR Curve, MTC Speed-Flow Curve, Akçelik Speed-Flow Curve are some extraordinary efforts to define the shape of speed-flow curve. However, the complexity of driver’s behaviour, interactions among different type of vehicles, lateral clearance, co-relation of driver’s psychology with vehicular characteristics and interdependence of various variables of traffic has led to continuous development and refinement of speed-flow curves. The problem gets more tedious in case of urban roads with heterogeneous traffic, oversaturated flow and signalized network (which includes some unsignalized intersections as well. This paper presents speed-flow analysis for urban roads with interrupted flow comprising of heterogeneous traffic. Model has been developed for heterogeneous traffic under constraints of roadway geometry, vehicle characteristics, driving behaviour and traffic controls. The model developed in this paper shall predict speed, delay, average queue and maximum queue estimates for urban roads and quantify congestion for oversaturated condition. The investigation details oversaturated portion of flow in particular.

  6. The Effect of Total Cumulative Dose, Number of Treatment Cycles, Interval between Injections, and Length of Treatment on the Frequency of Occurrence of Antibodies to Botulinum Toxin Type A in the Treatment of Muscle Spasticity

    Science.gov (United States)

    Bakheit, Abdel Magid O.; Liptrot, Anthea; Newton, Rachel; Pickett, Andrew M.

    2012-01-01

    A large cumulative dose of botulinum toxin type A (BoNT-A), frequent injections, a short interval between treatment cycles, and a long duration of treatment have all been suggested, but not confirmed, to be associated with a high incidence of neutralizing antibodies to the neurotoxin. The aim of this study was to investigate whether these…

  7. Re-configurable digital receiver for optically envelope detected half cycle BPSK and MSK radio-on-fiber signals

    DEFF Research Database (Denmark)

    Guerrero Gonzalez, Neil; Prince, Kamau; Zibar, Darko;

    2011-01-01

    novel digital receiver consists of a digital signal processing unit integrating functions such as filtering, peak-powers detection, symbol synchronization and signal demodulation for optically envelope detected half-cycle binary phase-shift-keying and minimum-shift-keying signals. Furthermore, radio......-frequency signal down-conversion is not required in our proposed approach; simplifying evens more the optical receiver front-end. We experimentally demonstrate error-free optical transmission (bit-error rate corresponding to 10−3 related to FEC-compatible levels) for both 416.6 Mbit/s half-cycle binary phase......-shift-keying and 104.17 Mbit/s minimum-shift-keying radio-frequency modulated signals after 30 km of fiber transmission....

  8. Calcium signaling and T-type calcium channels in cancer cell cycling

    Institute of Scientific and Technical Information of China (English)

    James T Taylor; Xiang-Bin Zeng; Jonathan E Pottle; Kevin Lee; Alun R Wang; Stephenie G Yi; Jennifer A S Scruggs; Suresh S Sikka; Ming Li

    2008-01-01

    Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells,free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear;however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers.

  9. SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Chetty, Chandramu [Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL-61605 (United States); Dontula, Ranadheer [Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine at Chicago, 840 South Wood Street, Suite 820-E, Chicago, IL-60612 (United States); Ganji, Purnachandra Nagaraju [Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL-61605 (United States); Gujrati, Meena [Department of Pathology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL-61605 (United States); Lakka, Sajani S., E-mail: slakka@uic.edu [Section of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine at Chicago, 840 South Wood Street, Suite 820-E, Chicago, IL-60612 (United States)

    2012-01-13

    Highlights: Black-Right-Pointing-Pointer Ectopic expression of SPARC impaired cell proliferation in medulloblastoma cells. Black-Right-Pointing-Pointer SPARC expression induces STAT3 mediated cell cycle arrest in medulloblastoma cells. Black-Right-Pointing-Pointer SPARC expression significantly inhibited pre-established tumor growth in nude-mice. -- Abstract: Dynamic cell interaction with ECM components has profound influence in cancer progression. SPARC is a component of the ECM, impairs the proliferation of different cell types and modulates tumor cell aggressive features. We previously reported that SPARC expression significantly impairs medulloblastoma tumor growth in vivo. In this study, we demonstrate that expression of SPARC inhibits medulloblastoma cell proliferation. MTT assay indicated a dose-dependent reduction in tumor cell proliferation in adenoviral mediated expression of SPARC full length cDNA (Ad-DsRed-SP) in D425 and UW228 cells. Flow cytometric analysis showed that Ad-DsRed-SP-infected cells accumulate in the G2/M phase of cell cycle. Further, immunoblot and immunoprecipitation analyses revealed that SPARC induced G2/M cell cycle arrest was mediated through inhibition of the Cyclin-B-regulated signaling pathway involving p21 and Cdc2 expression. Additionally, expression of SPARC decreased STAT3 phosphorylation at Tyr-705; constitutively active STAT3 expression reversed SPARC induced G2/M arrest. Ad-DsRed-SP significantly inhibited the pre-established orthotopic tumor growth and tumor volume in nude-mice. Immunohistochemical analysis of tumor sections from mice treated with Ad-DsRed-SP showed decreased immunoreactivity for pSTAT3 and increased immunoreactivity for p21 compared to tumor section from mice treated with mock and Ad-DsRed. Taken together our studies further reveal that STAT3 plays a key role in SPARC induced G2/M arrest in medulloblastoma cells. These new findings provide a molecular basis for the mechanistic understanding of the

  10. Bound Maxima as a Traffic Feature under DDOS Flood Attacks

    Directory of Open Access Journals (Sweden)

    Jie Xue

    2012-01-01

    Full Text Available This paper gives a novel traffic feature for identifying abnormal variation of traffic under DDOS flood attacks. It is the histogram of the maxima of the bounded traffic rate on an interval-by-interval basis. We use it to experiment on the traffic data provided by MIT Lincoln Laboratory under Defense Advanced Research Projects Agency (DARPA in 1999. The experimental results profitably enhance the evidences that traffic rate under DDOS attacks is statistically higher than that of normal traffic considerably. They show that the pattern of the histogram of the maxima of bounded rate of attack-contained traffic greatly differs from that of attack-free traffic. Besides, the present traffic feature is simple in mathematics and easy to use in practice.

  11. Serum IgE clearance is facilitated by human FcεRI internalization

    Science.gov (United States)

    Greer, Alexandra M.; Wu, Nan; Putnam, Amy L.; Woodruff, Prescott G.; Wolters, Paul; Kinet, Jean-Pierre; Shin, Jeoung-Sook

    2014-01-01

    The high-affinity IgE receptor FcεRI is constitutively expressed in mast cells and basophils and is required for transmitting stimulatory signals upon engagement of IgE-bound allergens. FcεRI is also constitutively expressed in dendritic cells (DCs) and monocytes in humans; however, the specific functions of the FcεRI expressed by these cells are not completely understood. Here, we found that FcεRI expressed by human blood DC antigen 1–positive (BDCA1+) DCs and monocytes, but not basophils, traffics to endolysosomal compartments under steady-state conditions. Furthermore, IgE bound to FcεRI on BDCA1+ DCs was rapidly endocytosed, transported to the lysosomes, and degraded in vitro. IgE injected into mice expressing human FcεRIα (FCER1A-Tg mice) was endocytosed by conventional DCs and monocytes, and endocytosis was associated with rapid clearance of circulating IgE from these mice. Importantly, this rapid IgE clearance was dependent on monocytes or DCs but not basophils. These findings strongly suggest that constitutive internalization of human FcεRI by DCs and monocytes distinctively contributes to serum IgE clearance. PMID:24569373

  12. Timbre-induced pitch shift from the perspective of Signal Detection Theory: the impact of musical expertise, silence interval, and pitch region.

    Science.gov (United States)

    Vurma, Allan

    2014-01-01

    The paradigm of Signal Detection Theory (SDT) was used to analyze the ability of professional pianists (N = 16) and string players (N = 15) to discriminate small F0 differences between consecutive musical tones, presented in pairs, with identical and with different (bright and dull) timbres. The sensitivity (d') and response bias (c) were heavily dependent on the timbral arrangement of the pairs of tones (the "comparable tones"), which can be interpreted as the influence of timbre-induced pitch shift on F0 discrimination. The participants were somewhat biased to "miss" signals when comparable tones had identical timbres and to make "false alarms" when the tones had different timbres. The d' was lowest when the tones with a lower F0 in those stimulus-pairs containing tones with different timbres had a brighter timber, and highest when both tones had bright timbre. On average, the string players had a somewhat higher d' and their perception was slightly less influenced by timbre-induced pitch shift when compared to the pianists. Nevertheless, the dependence of d' and c on the timbral arrangement of the tones was registered in the case of all the participants at all the investigated pitch regions around D#3, D4, and C#5. Furthermore, the presence of a silence of 3.5 s-a silence interval-between the tones to be compared had an impact on both d'- and c-values as well as on the degree of vulnerability to timbre-induced pitch shift. PMID:24550867

  13. An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement

    Directory of Open Access Journals (Sweden)

    Jason E. Streeter, Paul A. Dayton

    2013-01-01

    Full Text Available Competitive inhibition diminishes ligand adhesion as receptor sites become occupied with competing ligands. It is unknown if this effect occurs in ultrasound molecular imaging studies where endothelial binding sites become occupied with adherent bubbles or bubble fragments. The goal of this pilot study was to assess the effect that repeated administration and clearance of targeted agents has on successive adhesion. Two groups of animals were imaged with 3-D ultrasonic molecular imaging. Injections and imaging were performed on Group 1 at time 0 and 60 minutes. Group 2 received injections of microbubbles at 0, 15, 30, 45 and 60 minutes with imaging at 0 and 60 minutes. At 60 minutes, Group 1 targeting relative to baseline was not significantly different from Group 2 (1.06±0.27 vs. 1.08±0.34, p=0.93. Data suggest that multiple injections of targeted microbubbles do not block sufficient binding sites to bias molecular imaging data in serial studies.

  14. Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator

    OpenAIRE

    Flegg Jennifer A; Guerin Philippe J; White Nicholas J; Stepniewska Kasia

    2011-01-01

    Abstract Background A significant reduction in parasite clearance rates following artesunate treatment of falciparum malaria, and increased failure rates following artemisinin combination treatments (ACT), signaled emergent artemisinin resistance in Western Cambodia. Accurate measurement of parasite clearance is therefore essential to assess the spread of artemisinin resistance in Plasmodium falciparum. The slope of the log-parasitaemia versus time relationship is considered to be the most ro...

  15. Renal Clearance of Nanoparticles

    OpenAIRE

    Choi, Hak Soo; Liu, Wenhao; Misra, Preeti; Tanaka, Eiichi; Zimmer, John P.; Ipe, Binil Itty; Bawendi, Moungi G.; Frangioni, John V.

    2007-01-01

    The field of nanotechnology holds great promise for the diagnosis and treatment of human disease. However, the size and charge of most nanoparticles preclude their efficient clearance from the body as intact nanoparticles. Without such clearance or their biodegradation into biologically benign components, toxicity is potentially amplified and radiological imaging is hindered. Using quantum dots (QDs) as a model system, we have precisely defined the requirements for renal filtration and urinar...

  16. Optimisation-based clearance

    OpenAIRE

    Varga, Andras

    2002-01-01

    The basic feature of the optimisation-based clearance approach is to reformulate the clearance problems as equivalent minimum distance problems for which ”anti”-optimisation is performed to determine the worst-case parameter combination/ flight condition leading to worst performance. The basic requirements for the applicability of the optimisation-based approach are the availability of suitable parametric models describing the overall nonlinear dynamics of the augmented aircraft and of accomp...

  17. Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs.

    Directory of Open Access Journals (Sweden)

    Ko Sato

    Full Text Available Type I interferons (IFNs are secreted by many cell types upon stimulation via pattern recognition receptors and bind to IFN-α/β receptor (IFNAR, which is composed of IFNAR1 and IFNAR2. Although type I IFNs are well known as anti-viral cytokines, limited information is available on their role during fungal infection. In the present study, we addressed this issue by examining the effect of IFNAR1 defects on the host defense response to Cryptococcus neoformans. In IFNAR1KO mice, the number of live colonies was lower and the host immune response mediated not only by Th1 but also by Th2 and Th17-related cytokines was more accelerated in the infected lungs than in WT mice. In addition, mucin production by bronchoepithelial cells and expression of MUC5AC, a major core protein of mucin in the lungs, were significantly higher in IFNAR1KO mice than in WT mice. This increase in mucin and MUC5AC production was significantly inhibited by treatment with neutralizing anti-IL-4 mAb. In contrast, administration of recombinant IFN-αA/D significantly suppressed the production of IL-4, but not of IFN-γ and IL-17A, in the lungs of WT mice after cryptococcal infection. These results indicate that defects of IFNAR1 led to improved clearance of infection with C. neoformans and enhanced synthesis of IFN-γ and the IL-4-dependent production of mucin. They also suggest that type I IFNs may be involved in the negative regulation of early host defense to this infection.

  18. Raf-1 Physically Interacts with Rb and Regulates Its Function: a Link between Mitogenic Signaling and Cell Cycle Regulation

    OpenAIRE

    Wang, Sheng; Ghosh, Richik N.; Chellappan, Srikumar P

    1998-01-01

    Cells initiate proliferation in response to growth factor stimulation, but the biochemical mechanisms linking signals received at the cell surface receptors to the cell cycle regulatory molecules are not yet clear. In this study, we show that the signaling molecule Raf-1 can physically interact with Rb and p130 proteins in vitro and in vivo and that this interaction can be detected in mammalian cells without overexpressing any component. The binding of Raf-1 to Rb occurs subsequent to mitogen...

  19. Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jung-Yoon; Kim, Tae Hoon; Lee, Jae Hee [Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI (United States); Dunwoodie, Sally L. [Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010 (Australia); St. Vincent' s Clinical School and the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales 2033 (Australia); Ku, Bon Jeong, E-mail: bonjeong@cnu.ac.kr [Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon (Korea, Republic of); Jeong, Jae-Wook, E-mail: JaeWook.Jeong@hc.msu.edu [Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI (United States); Department of Women' s Health, Spectrum Health System, Grand Rapids, MI (United States)

    2015-07-10

    Mitogen inducible gene 6 (Mig-6) is an important mediator of progesterone (P4) signaling to inhibit estrogen (E2) signaling in the uterus. Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and E2-induced endometrial cancer. To identify the molecular pathways regulated by Mig-6, we performed microarray analysis on the uterus of ovariectomized Mig-6{sup f/f} and PGR{sup cre/+}Mig-6{sup f/f} (Mig-6{sup d/d}) mice treated with vehicle or P4 for 6 h. The results revealed that 772 transcripts were significantly regulated in the Mig-6{sup d/d} uterus treated with vehicle as compared with Mig-6{sup f/f} mice. The pathway analysis showed that Mig-6 suppressed the expression of gene-related cell cycle regulation in the absence of ovarian steroid hormone. The epithelium of Mig-6{sup d/d} mice showed a significant increase in the number of proliferative cells compared to Mig-6{sup f/f} mice. This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis. To determine the role of Cited2 in the uterus, we used the mice with Cited2 that were conditionally ablated in progesterone receptor-positive cells (PGR{sup cre/+}Cited2{sup f/f}; Cited2{sup d/d}). Ablation of Cited2 in the uterus resulted in a significant reduction in the ability of the uterus to undergo a hormonally induced decidual reaction. Identification and analysis of these responsive genes will help define the role of P4 as well as Mig-6 in regulating uterine biology. - Highlights: • We identify Mig-6- and P4-regulated uterine genes by microarray analysis. • Mig-6 suppresses cell cycle progression and epithelial cell proliferation in uterus. • We identify the Mig-6 dependent induced genes by P4. • Cited2 plays an important role for decidualization as a P4 and Mig-6 target gene.

  20. Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling

    International Nuclear Information System (INIS)

    Mitogen inducible gene 6 (Mig-6) is an important mediator of progesterone (P4) signaling to inhibit estrogen (E2) signaling in the uterus. Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and E2-induced endometrial cancer. To identify the molecular pathways regulated by Mig-6, we performed microarray analysis on the uterus of ovariectomized Mig-6f/f and PGRcre/+Mig-6f/f (Mig-6d/d) mice treated with vehicle or P4 for 6 h. The results revealed that 772 transcripts were significantly regulated in the Mig-6d/d uterus treated with vehicle as compared with Mig-6f/f mice. The pathway analysis showed that Mig-6 suppressed the expression of gene-related cell cycle regulation in the absence of ovarian steroid hormone. The epithelium of Mig-6d/d mice showed a significant increase in the number of proliferative cells compared to Mig-6f/f mice. This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis. To determine the role of Cited2 in the uterus, we used the mice with Cited2 that were conditionally ablated in progesterone receptor-positive cells (PGRcre/+Cited2f/f; Cited2d/d). Ablation of Cited2 in the uterus resulted in a significant reduction in the ability of the uterus to undergo a hormonally induced decidual reaction. Identification and analysis of these responsive genes will help define the role of P4 as well as Mig-6 in regulating uterine biology. - Highlights: • We identify Mig-6- and P4-regulated uterine genes by microarray analysis. • Mig-6 suppresses cell cycle progression and epithelial cell proliferation in uterus. • We identify the Mig-6 dependent induced genes by P4. • Cited2 plays an important role for decidualization as a P4 and Mig-6 target gene

  1. TGF-β Signaling Regulates Pancreatic β-Cell Proliferation through Control of Cell Cycle Regulator p27 Expression

    International Nuclear Information System (INIS)

    Proliferation of pancreatic β-cells is an important mechanism underlying β-cell mass adaptation to metabolic demands. Increasing β-cell mass by regeneration may ameliorate or correct both type 1 and type 2 diabetes, which both result from inadequate production of insulin by β-cells of the pancreatic islet. Transforming growth factor β (TGF-β) signaling is essential for fetal development and growth of pancreatic islets. In this study, we exposed HIT-T15, a clonal pancreatic β-cell line, to TGF-β signaling. We found that inhibition of TGF-β signaling promotes proliferation of the cells significantly, while TGF-β signaling stimulation inhibits proliferation of the cells remarkably. We confirmed that this proliferative regulation by TGF-β signaling is due to the changed expression of the cell cycle regulator p27. Furthermore, we demonstrated that there is no observed effect on transcriptional activity of p27 by TGF-β signaling. Our data show that TGF-β signaling mediates the cell-cycle progression of pancreatic β-cells by regulating the nuclear localization of CDK inhibitor, p27. Inhibition of TGF-β signaling reduces the nuclear accumulation of p27, and as a result this inhibition promotes proliferation of β-cells

  2. Selecting noise source and traffic representations that capture urban traffic noise dynamics

    OpenAIRE

    CAN, Arnaud; Leclercq, Ludovic; Lelong, Joël

    2009-01-01

    Considering traffic dynamics greatly improves noise estimation in urban area. This can be achieved by coupling a dynamic traffic model with both noise emission laws and sound propagation calculation. Determining the relevant noise source and traffic representations to estimate classical noise descriptors (LAeq and statistical descriptors) near traffic signals has been recently studied. This research topic is extended in this paper to more specific descriptors which are able to capture noise d...

  3. Automatic Traffic Density Estimation and Vehicle Classification for Traffic Surveillance Systems using Neural Networks

    OpenAIRE

    Ozkurt, Celil; Camci, Fatih

    2009-01-01

    It is important to know the road traffic density real time especially in mega cities for signal control and effective traffic management. In recent years, video monitoring and surveillance systems have been widely used in traffic management. Hence, traffic density estimation and vehicle classification can be achieved using video monitoring systems. In most vehicle detection methods in the literature, only the detection of vehicles in frames of the given video is emphesized. However, further a...

  4. Investigating traffic light violations by cyclists in Dublin City Centre.

    Science.gov (United States)

    Richardson, Matthew; Caulfield, Brian

    2015-11-01

    This research examines the behaviour of cyclists in Dublin City with specific regard to red light running. A number of specific research questions are raised by this study. These questions address the impact of different infrastructure types on red light running, as well as the behavioural patterns and demographics of offending cyclists. Two data collection methods were used to gather information on cyclists in Dublin City - an observational survey and an online questionnaire. The observational surveys examined cyclist compliance with different traffic signal systems and the impact of on-road and off-road cycle infrastructure. An online questionnaire was used to get direct feedback from cyclists in Dublin City on the reasons (if any) they decide to commit infringement at traffic lights. With the recent growth of cycling in Dublin City (as well as many other international cities) it is vital to accommodate and manage this growing demand by ensuring the safety and road discipline of cyclists. The next few years will be crucial for the continued development of cycling in Dublin, particularly due to the increasing investment by transport planners in cycle infrastructure. It is therefore important to identify now the main factors which influence cyclist's decisions to break red lights in order to guide local traffic authorities in their efforts to reduce such transgressions. PMID:26320736

  5. Timbre-induced pitch shift from the perspective of Signal Detection Theory: the impact of musical expertise, silence interval and pitch region

    Directory of Open Access Journals (Sweden)

    Allan eVurma

    2014-01-01

    Full Text Available The paradigm of Signal Detection Theory was used to analyze the ability of professional pianists (N = 16 and string players (N = 15 to discriminate small F0 differences between consecutive musical tones, presented in pairs, with identical and with different (bright and dull timbres. The sensitivity (d’ and response bias (c were heavily dependent on the timbral arrangement of the pairs of tones (the comparable tones, which can be interpreted as the influence of timbre-induced pitch shift on F0 discrimination. The participants were somewhat biased to ‘miss’ signals when comparable tones had identical timbres and to make ‘false alarms’ when the tones had different timbres. The d’ was lowest when the tones with a lower F0 in those stimulus-pairs containing tones with different timbres had a brighter timber, and highest when both tones had bright timbre. On average, the string players had a somewhat higher d’ and their perception was slightly less influenced by timbre-induced pitch shift when compared to the pianists. Nevertheless, the dependence of d’ and c on the timbral arrangement of the tones was registered in the case of all the participants at all the investigated pitch regions around D#3, D4 and C#5. Furthermore, the presence of a silence of 3.5 seconds – a silence interval – between the tones to be compared had an impact on both d’ and c values as well as on the degree of vulnerability to timbre-induced pitch shift.

  6. Theory of clearance-phase-adjustor in pneumatically-driven split-Stirling-cycle cryocooler with clearance-phase-adjustor%狭缝调相式气动分置式斯特林制冷机的调相器理论

    Institute of Scientific and Technical Information of China (English)

    张存泉; 吴亦农

    2008-01-01

    给出的狭缝调相式气动分置式斯特林制冷机,具有阻尼调节方便、造价低、制作与装配简单等优点.该机使用调节件与气动腔体之间的缝隙替代气动杆上的干摩擦来调节排出器的运动阻尼,进而调节排出器与活塞之间的运动相位差.主要给出了狭缝调相器的理论模型,并针对不同间隙进行了性能模拟与试验验证.试验结果与性能模拟结果符合很好,证明了所建立理论模型的可行性.%The concept of pneumatically-driven split-Stirling-cycle cryocooler with clearance-phase.adjustor is proposed.It has the advantages of easy damping adjusting,low cost,simplifying manufacturing and assembling.The gap between the phase-adjusting part and the cylinder of spring chamber instead of dry friction acted on the pneumaticlly-driven rod is used to control motion damping of the displacer and adjust the phabe difference between the compression piston and displacer.A theoretical model for the clerance-phase-adjustor has been established and dynamic simulation of its operating performance at different gaps is demonstrated in this paper.The simulation resul are in good agreement with the experiment ones,therefore the theoretical model is feasible and reliable for the simulation.

  7. Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair

    DEFF Research Database (Denmark)

    Christensen, Søren T; Pedersen, Stine F; Satir, Peter; Veland, Iben R; Schneider, Linda

    2008-01-01

    Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an...

  8. 采用系统科学方法优化交通信号灯的控制策略%Optimization Control Strategy of Traffic Signal with System Scientific Methods

    Institute of Scientific and Technical Information of China (English)

    张世良

    2012-01-01

    In order to control vehicles easily pass in the intersection,on the basis of the introduction of system structure for traffic signal lamp,run mode and workflow,this paper analyzes different ways in system control which can use different operation patterns at different times to adaptively control vehicle pass time.Traffic induction strategies which can use different open moment according to the space between the two intersections is used to reduce waiting time for vehicle,improve pass efficiency and ensure efficient circulation in the whole traffic system,and other traffic information,such as vehicle speed,type and traffic by vehicle labels can provide basic data of traffic forecast for the road long-term planning and is signality to direct intelligent traffic control.%为了控制车辆在交叉路口顺畅通行,本文在介绍交通信号灯系统结构、运行模式及工作流程的基础上,分析了系统控制中不同策略的方法,使用在不同的时段采用不同的路口控制模式,自适应地控制车辆通行时间,并根据路口间距采用不同的开启时刻以及使用交通诱导策略,减少车辆等待时间,提高车辆通行效率,保证整个交通系统的高效流通,而且通过车载标签及时掌握的车速、车型和交通量等交通信息可以为该路段远期规划的交通预测提供基础数据,对智能交通控制具有很大的指导意义。

  9. Generic Clearance Values

    International Nuclear Information System (INIS)

    This paper analyzes the Generic Clearance Values established for natural and artificial radionuclides with the objective of evaluating their degree of conservatism in views of adopting them into the regulatory body. Generic clearance values for natural radionuclides have been chosen by experts judgments as the optimum boundary between, on the one hand, the ubiquitous unmodified soil concentrations and, on the other hand, activity concentrations in ores, mineral sands, industrial residues and wastes. For artificial radionuclides the clearance levels have been derived from the scenarios postulated in the document Safety Reports Series 44 of the IAEA considering quantitative exemption criteria. A set of 8 scenarios were postulated covering external, ingestion and inhalation exposure pathways. For each radionuclide, the generic clearance level was derived as the more restrictive value obtained from the scenarios, that is the lowest ratio between the applicable individual dose and the dose per unit activity concentration (Bq/g). The individual dose was calculated by a formula depending on each scenario and pathway, with different parameters, such as exposure time, dosimetric factors, dilution factor, density of the material, geometric factors, etc. It was concluded that the basis and parameters used for the derivation of the generic clearance levels are quite conservative and therefore its the adoption in Argentina has been recommended. It is expected that their implementation will contribute to optimize the regulatory management system. (authors)

  10. Generic clearance values

    International Nuclear Information System (INIS)

    This paper analyzes the Generic Clearance Values established for natural and artificial radionuclides with the objective of evaluating their degree of conservatism in views of adopting them into the regulatory body. Generic clearance values for natural radionuclides have been chosen by experts judgments as the optimum boundary between, on one hand, the ubiquitous unmodified soil concentrations and, on the other hand, activity concentrations in ores, mineral sands, industrial residues and wastes. For artificial radionuclides the clearance levels have been derived from the scenarios postulated in the document 'Safety Reports Series Nr 44' of the IAEA considering quantitative exemption criteria. A set of 8 scenarios were postulated covering external, ingestion and inhalation exposure pathways. For each radionuclide, the generic clearance level was derived as the more restrictive value obtained from the scenarios, that is the lowest ratio between the applicable individual dose and the dose per unit activity concentration (Bq/g). The individual dose was calculated by a formula depending on each scenario and pathway, with different parameters, such as exposure time, dosimetric factors, dilution factor, density of the material, geometric factors, etc. It was concluded that the basis and parameters used for the derivation of the generic clearance levels are quite conservative and therefore its the adoption in Argentina has been recommended. It is expected that their implementation will contribute to optimize the regulatory management system. (author)

  11. Study on clearance system

    International Nuclear Information System (INIS)

    The clearance system is a legal system to release 'the radioactive waste not requiring treatment as radioactive waste' from the regulatory control. JNES supports NISA on approval and confirmation of clearance measurement and judgment developed by the operator. The objective of this study is to establish technical base of the validation method of the clearance measurement for various objects. In reactor facilities, the bulk measurement technique or the statistical sampling measurement technique may be applied to large scale objects or concrete walls. In this study, the criteria of those techniques were examined. In uranium processing facilities, it is important to confirm surface state of the object in case of detecting alpha rays. The result of the examination about the influence of the surface rust in the uranium clearance measurement by the alpha ray measurement showed that the pollution was distributed in rust layer uniformly. This result will be reflected to the revision of the Ministerial Ordinance on Clearance in 2011FY. To develop a manual for unexpected incidents, the response procedure for an unexpected incident was prepared, including a response system. (author)

  12. Study on clearance system

    International Nuclear Information System (INIS)

    The clearance system is a legal word to define as 'the waste not requiring treatment as radioactive waste' on the regulatory control. JNES supports NISA on the approval and the confirmation of clearance measurement by the operator. The objective of this study is to establish technical base of the validation method of the clearance measurement for various objects. In reactor facilities, the statistical sampling measurement technique may be applied to large scale objects. In this study, the criteria of the techniques were examined, and the strategy for setting of radioactivity concentration evaluation level was prepared. In uranium processing facilities, simulation sources to apply to a validity confirmation examination of the measuring equipment were made, and these applicability and problem were studied. The method of the validity evaluation of the performance confirmation of the measuring equipment was devised by measurement experiment using this source. The manual for unexpected incidents which maintained in FY2011 was reviced by reflection of the experience of the radioactivity concentration measurement of disaster waste contaminated by the accident of Fukushima Dai-ichi NPS. JNES also supports NISA technically for the issue on influence of fall out from Fukushima Dai-ichi NPS on clearance system and NR system. In addition, the latest situation of a clearance system operated in Europe was studied. (author)

  13. Initial Investigations of Controller Tools and Procedures for Schedule-Based Arrival Operations with Mixed Flight-Deck Interval Management Equipage

    Science.gov (United States)

    Callantine, Todd J.; Cabrall, Christopher; Kupfer, Michael; Omar, Faisal G.; Prevot, Thomas

    2012-01-01

    NASA?s Air Traffic Management Demonstration-1 (ATD-1) is a multi-year effort to demonstrate high-throughput, fuel-efficient arrivals at a major U.S. airport using NASA-developed scheduling automation, controller decision-support tools, and ADS-B-enabled Flight-Deck Interval Management (FIM) avionics. First-year accomplishments include the development of a concept of operations for managing scheduled arrivals flying Optimized Profile Descents with equipped aircraft conducting FIM operations, and the integration of laboratory prototypes of the core ATD-1 technologies. Following each integration phase, a human-in-the-loop simulation was conducted to evaluate and refine controller tools, procedures, and clearance phraseology. From a ground-side perspective, the results indicate the concept is viable and the operations are safe and acceptable. Additional training is required for smooth operations that yield notable benefits, particularly in the areas of FIM operations and clearance phraseology.

  14. Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1

    International Nuclear Information System (INIS)

    Topoisomerase II is essential for cell proliferation and survival and has been a target of various anticancer drugs. ICRF-193 has long been used as a catalytic inhibitor to study the function of topoisomerase II. Here, we show that ICRF-193 treatment induces DNA damage signaling. Treatment with ICRF-193 induced G2 arrest and DNA damage signaling involving γ-H2AX foci formation and CHK2 phosphorylation. DNA damage by ICRF-193 was further demonstrated by formation of the nuclear foci of 53BP1, NBS1, BRCA1, MDC1, and FANCD2 and increased comet tail moment. The DNA damage signaling induced by ICRF-193 was mediated by ATM and ATR and was restricted to cells in specific cell cycle stages such as S, G2, and mitosis including late and early G1 phases. Downstream signaling of ATM and ATR involved the phosphorylation of CHK2 and BRCA1. Altogether, our results demonstrate that ICRF-193 induces DNA damage signaling in a cell cycle-dependent manner and suggest that topoisomerase II might be essential for the progression of the cell cycle at several stages including DNA decondensation

  15. Delays at signalised intersections with exhaustive traffic control

    OpenAIRE

    Boon, MAA Marko; Adan, IJBF Ivo; Winands, EMM Erik; Down, DG

    2014-01-01

    In this paper we study a traffic intersection with vehicle-actuated traffic signal control. Traffic lights stay green until all lanes within a group are emptied. Assuming general renewal arrival processes, we derive exact limiting distributions of the delays under Heavy Traffic (HT) conditions. Furthermore, we derive the Light Traffic (LT) limit of the mean delays for intersections with Poisson arrivals, and develop a heuristic adaptation of this limit to capture the LT behaviour for other in...

  16. On Traffic Light Control of Regular Towns

    OpenAIRE

    Mancinelli, Elina; Cohen, Guy; Gaubert, Stéphane; Quadrat, Jean-Pierre; Rofman, Edmundo

    2001-01-01

    We present a hierarchical way of designing the traffic light control of regular towns. We first give a a model for light synchronization based on Petri nets and minplus algebra. Using this modelling we decompose the problem in three parts : - computation of the cycle length of each traffic light, - computation of the starting time of each traffic light cycle, - computation of the proportion of the green and red length in a cycle. The example of the Bahía Blanca, city of Argentina, is given.

  17. Interbirth intervals

    OpenAIRE

    Haig, David

    2014-01-01

    Background and objectives: Interbirth intervals (IBIs) mediate a trade-off between child number and child survival. Life history theory predicts that the evolutionarily optimal IBI differs for different individuals whose fitness is affected by how closely a mother spaces her children. The objective of the article is to clarify these conflicts and explore their implications for public health. Methodology: Simple models of inclusive fitness and kin conflict address the evolution of human birth-...

  18. N-glycosylation at Asn residues 554 and 566 of E-cadherin affects cell cycle progression through extracellular signal-regulated protein kinase signaling pathway

    Institute of Scientific and Technical Information of China (English)

    Hongbo Zhao; Xiliang Zha; Lidong Sun; Liying Wang; Zhibin Xu; Feng Zhou; Jianmin Su; Jiawei Jin; Yong Yang; Yali Hu

    2008-01-01

    E-cadherin, which has a widely acknowledged role in mediating calcium-dependent cell-cell adhesion between epithelial cells, also functions as a tumor suppressor. The ectodomain of human E-cadherin contains four potential N-glycosylation sites at Asn residues 554, 566, 618, and 633.We investigated the role of E-cadherin N-glycosylation in cell cycle progression by site-directed mutagenesis. We showed previously that all four potential N-glycosylation sites of E-cadherin were N-glycosylated in human breast carcinoma MDA-MB-435 cells. Removal of N-glycan at Asn633 dramatically affected E-cadherin stability. In this study we showed that E-cadherin mutant missing N-glycans at Asn554, Asn566 and Asn618 failed to induce cell cycle arrest in G1 phase and to suppress cell proliferation in comparison with wild-type E-cadherin. Moreover, N-glycans at Asn554 and Asn566, but not at Asn618, seemed to be indispensable for E-cadherin-mediated suppression of cell cycle progression.Removal of N-glycans at either Asn554 or Asn566 of E-cadherin was accompanied with the activation of the extracellular signal-regulated protein kinase signaling pathway. After treatment with PD98059, an inhibitor of the extraceilular signal-regulated protein kinase signaling pathway, wild-type E-cadherin transfected MDA-MB-435 and E-cadherin N-glycosylation-deficient mutant transfected MDA-MB-435 cells had equivalent numbers of cells in G1 phase. These findings implied that N-glycosylation might be crucial for E-cadherin-mediated suppression of cell cycle progression.

  19. Exploring the influential factors in incident clearance time: Disentangling causation from self-selection bias.

    Science.gov (United States)

    Ding, Chuan; Ma, Xiaolei; Wang, Yinhai; Wang, Yunpeng

    2015-12-01

    Understanding the relationships between influential factors and incident clearance time is crucial to make effective countermeasures for incident management agencies. Although there have been a certain number of achievements on incident clearance time modeling, limited effort is made to investigate the relative role of incident response time and its self-selection in influencing the clearance time. To fill this gap, this study uses the endogenous switching model to explore the influential factors in incident clearance time, and aims to disentangle causation from self-selection bias caused by response process. Under the joint two-stage model framework, the binary probit model and switching regression model are formulated for both incident response time and clearance time, respectively. Based on the freeway incident data collected in Washington State, full information maximum likelihood (FIML) method is utilized to estimate the endogenous switching model parameters. Significant factors affecting incident response time and clearance time can be identified, including incident, temporal, geographical, environmental, traffic and operational attributes. The estimate results reveal the influential effects of incident, temporal, geographical, environmental, traffic and operational factors on incident response time and clearance time. In addition, the causality of incident response time itself and its self-selection correction on incident clearance time are found to be indispensable. These findings suggest that the causal effect of response time on incident clearance time will be overestimated if the self-selection bias is not considered. PMID:26373988

  20. The fully actuated traffic control problem solved by global optimization and complementarity

    Science.gov (United States)

    Ribeiro, Isabel M.; de Lurdes de Oliveira Simões, Maria

    2016-02-01

    Global optimization and complementarity are used to determine the signal timing for fully actuated traffic control, regarding effective green and red times on each cycle. The average values of these parameters can be used to estimate the control delay of vehicles. In this article, a two-phase queuing system for a signalized intersection is outlined, based on the principle of minimization of the total waiting time for the vehicles. The underlying model results in a linear program with linear complementarity constraints, solved by a sequential complementarity algorithm. Departure rates of vehicles during green and yellow periods were treated as deterministic, while arrival rates of vehicles were assumed to follow a Poisson distribution. Several traffic scenarios were created and solved. The numerical results reveal that it is possible to use global optimization and complementarity over a reasonable number of cycles and determine with efficiency effective green and red times for a signalized intersection.

  1. Dynamic Ground Clearance

    OpenAIRE

    Hamache, Violette

    2013-01-01

    The purpose of this work is to develop a test method which will consider the variation of the ground clearance when driving, the so-called dynamic ground clearance. This has been done through the analysis of a specific application: the tractors in grain used in Brazil. Series of real life tests are run in order to obtain data on the tire compressions and the suspension travels. The tractor used is a 6x4 and is loaded with a trailer. When investigating critical cases, the minimum dynamic groun...

  2. Wavelet Neural Network Based Traffic Prediction for Next Generation Network

    Institute of Scientific and Technical Information of China (English)

    Zhao Qigang; Li Qunzhan; He Zhengyou

    2005-01-01

    By using netflow traffic collecting technology, some traffic data for analysis are collected from a next generation network (NGN) operator. To build a wavelet basis neural network (NN), the Sigmoid function is replaced with the wavelet in NN. Then the wavelet multiresolution analysis method is used to decompose the traffic signal, and the decomposed component sequences are employed to train the NN. By using the methods, an NGN traffic prediction model is built to predict one day's traffic. The experimental results show that the traffic prediction method of wavelet NN is more accurate than that without using wavelet in the NGN traffic forecasting.

  3. ADRENOMEDULLIN SIGNALLING IN BOVINE CORPUS LUTEUM DURING OESTROUS CYCLE, GRAVIDITY AND INDUCED LUTEOLYSIS

    Directory of Open Access Journals (Sweden)

    Stefanie Schilffarth

    2010-08-01

    Full Text Available Investigations on "nonclassic" regulators of angiogenesis could open new perspectives in understanding angiogenesis under physiological and pathological conditions. A pro-angiogenic effect has been demonstrated for adrenomedullin (AM, it´s co-factor activity-modifying protein 2 (RAMP-2 and the calcitonin receptor-like receptor (CALCLR. This signalling pathway is besides associated with lymphangiogenesis, that (in a physiologically way is still only poorly understood in ovary and its structures. The aim of this study was therefore to evaluate mRNA expression of AM, RAMP-2 and CALCLR in bovine corpora lutea (CL during different physiological stages. Experiment 1: CL were assigned days 1-2, 3-4, 5-7, 8-12, 13-16, >18 (after regression of oestrous cycle and of gravidity (month 8. Experiment 2: Induced luteolysis. Cows on days 8-12 were injected with a PGF2α analogue and CL were collected by transvaginal ovariectomy before and 0.5, 2, 4, 12, 24, 48 and 64 h after PGF2α injection. Tissue levels of mRNA were characterized by qPCR. All 3 factors were clearly expressed. AM and CALCRL showed significant changes in both experiments, RAMP-2 during induced luteolysis. For AM highest levels could be observed in the beginning and the end of the luteal phase, CALCRL remained at around the same levels. Both factors showed their most expression at the end of pregnancy. During induced luteolysis all factors started to decline not until structural luteolysis. In conclusion, our results could lead to the assumption that factors investigated may be involved in mechanisms regulating CL formation, function and regression – and a special impact in the final month of pregnancy.

  4. Allometric scaling for predicting human clearance of bisphenol A

    International Nuclear Information System (INIS)

    The investigation of interspecies differences in bisphenol A (BPA) pharmacokinetics (PK) may be useful for translating findings from animal studies to humans, identifying major processes involved in BPA clearance mechanisms, and predicting BPA PK parameters in man. For the first time, a large range of species in terms of body weight, from 0.02 kg (mice) to 495 kg (horses) was used to predict BPA clearance in man by an allometric approach. BPA PK was evaluated after intravenous administration of BPA in horses, sheep, pigs, dogs, rats and mice. A non-compartmental analysis was used to estimate plasma clearance and steady state volume of distribution and predict BPA PK parameters in humans from allometric scaling. In all the species investigated, BPA plasma clearance was high and of the same order of magnitude as their respective hepatic blood flow. By an allometric scaling, the human clearance was estimated to be 1.79 L/min (equivalent to 25.6 mL/kg.min) with a 95% prediction interval of 0.36 to 8.83 L/min. Our results support the hypothesis that there are highly efficient and hepatic mechanisms of BPA clearance in man. - Highlights: • Allometric scaling was used to predict BPA pharmacokinetic parameters in humans. • In all species, BPA plasma clearance approached hepatic blood flow. • Human BPA clearance was estimated to be 1.79 L/min

  5. Allometric scaling for predicting human clearance of bisphenol A

    Energy Technology Data Exchange (ETDEWEB)

    Collet, Séverine H., E-mail: s.collet@envt.fr; Picard-Hagen, Nicole, E-mail: n.hagen-picard@envt.fr; Lacroix, Marlène Z., E-mail: m.lacroix@envt.fr; Puel, Sylvie, E-mail: s.puel@envt.fr; Viguié, Catherine, E-mail: c.viguie@envt.fr; Bousquet-Melou, Alain, E-mail: a.bousquet-Melou@envt.fr; Toutain, Pierre-Louis, E-mail: pltoutain@wanadoo.fr; Gayrard, Véronique, E-mail: v.gayrard@envt.fr

    2015-05-01

    The investigation of interspecies differences in bisphenol A (BPA) pharmacokinetics (PK) may be useful for translating findings from animal studies to humans, identifying major processes involved in BPA clearance mechanisms, and predicting BPA PK parameters in man. For the first time, a large range of species in terms of body weight, from 0.02 kg (mice) to 495 kg (horses) was used to predict BPA clearance in man by an allometric approach. BPA PK was evaluated after intravenous administration of BPA in horses, sheep, pigs, dogs, rats and mice. A non-compartmental analysis was used to estimate plasma clearance and steady state volume of distribution and predict BPA PK parameters in humans from allometric scaling. In all the species investigated, BPA plasma clearance was high and of the same order of magnitude as their respective hepatic blood flow. By an allometric scaling, the human clearance was estimated to be 1.79 L/min (equivalent to 25.6 mL/kg.min) with a 95% prediction interval of 0.36 to 8.83 L/min. Our results support the hypothesis that there are highly efficient and hepatic mechanisms of BPA clearance in man. - Highlights: • Allometric scaling was used to predict BPA pharmacokinetic parameters in humans. • In all species, BPA plasma clearance approached hepatic blood flow. • Human BPA clearance was estimated to be 1.79 L/min.

  6. Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning

    Science.gov (United States)

    Hadjivasiliou, Zena; Bonin, Hope; He, Li; Perrimon, Norbert; Charras, Guillaume; Baum, Buzz

    2016-01-01

    Coordinating cell differentiation with cell growth and division is crucial for the successful development, homeostasis and regeneration of multicellular tissues. Here, we use bristle patterning in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle, as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more distant neighbours, and lastly Delta-expressing cells. Conversely, mitotic entry and cell division makes ECs refractory to lateral inhibition signalling, fixing their fate. Using a combination of experiments and computational modelling, we show that this reciprocal relationship between Notch signalling and cell cycle progression acts like a developmental clock, providing a delimited window of time during which cells decide their fate, ensuring efficient and orderly bristle patterning. PMID:27226324

  7. Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.

    Science.gov (United States)

    Hunter, Ginger L; Hadjivasiliou, Zena; Bonin, Hope; He, Li; Perrimon, Norbert; Charras, Guillaume; Baum, Buzz

    2016-07-01

    Coordinating cell differentiation with cell growth and division is crucial for the successful development, homeostasis and regeneration of multicellular tissues. Here, we use bristle patterning in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs) becomes established through Notch-mediated lateral inhibition during G2 phase of the cell cycle, as neighbouring cells physically interact with each other via lateral contacts and/or basal protrusions. Since Notch signalling controls cell division timing downstream of Cdc25, ECs in lateral contact with a Delta-expressing cell experience higher levels of Notch signalling and divide first, followed by more distant neighbours, and lastly Delta-expressing cells. Conversely, mitotic entry and cell division makes ECs refractory to lateral inhibition signalling, fixing their fate. Using a combination of experiments and computational modelling, we show that this reciprocal relationship between Notch signalling and cell cycle progression acts like a developmental clock, providing a delimited window of time during which cells decide their fate, ensuring efficient and orderly bristle patterning. PMID:27226324

  8. A Comparison of Tram Priority at Signalized Intersections

    CERN Document Server

    Zhang, Lele

    2013-01-01

    We study tram priority at signalized intersections using a stochastic cellular automaton model for multimodal traffic flow. We simulate realistic traffic signal systems, which include signal linking and adaptive cycle lengths and split plans, with different levels of tram priority. We find that tram priority can improve service performance in terms of both average travel time and travel time variability. We consider two main types of tram priority, which we refer to as full and partial priority. Full tram priority is able to guarantee service quality even when traffic is saturated, however, it results in significant costs to other road users. Partial tram priority significantly reduces tram delays while having limited impact on other traffic, and therefore achieves a better result in terms of the overall network performance. We also study variations in which the tram priority is only enforced when trams are running behind schedule, and we find that those variations retain almost all of the benefit for tram op...

  9. Study on clearance system

    International Nuclear Information System (INIS)

    The clearance system is a legal system to release 'the radioactive waste not requiring treatment as radioactive waste' from the regulatory control. JNES supports Nuclear Regulatory Agency on approval and confirmation of clearance measurement and judgment developed by the operator. The objective of this study is to establish technical base of the validation method of the clearance measurement for various objects. In uranium processing facilities, simulation sources emitting alpha-rays is used in a validity confirmation examination of the measuring equipment. In this study, these sources were examined by measuring alpha and beta spectra to evaluate the applicability and problem of these sources. In addition, the measuring method detecting gamma-rays was examined. This method can be applied to complicated objects. As a part to develop a manual for unexpected incidents in clearance system, a quick method for measurement of Strontium 90 was examined. In addition, the measuring methods for the judgment of the influence of fallout and for NR (Non-Radioactive) confirmation were examined. (author)

  10. Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

    OpenAIRE

    Özlem Akilli Öztürk; Hubert Pakula; Jolanta Chmielowiec; Jingjing Qi; Simone Stein; Linxiang Lan; Yoshiteru Sasaki; Klaus Rajewsky; Walter Birchmeier

    2015-01-01

    Gab1 is a scaffold protein that acts downstream of receptor tyrosine kinases. Here, we produced conditional Gab1 mutant mice (by K14- and Krox20-cre) and show that Gab1 mediates crucial signals in the control of both the hair cycle and the self-renewal of hair follicle stem cells. Remarkably, mutant hair follicles do not enter catagen, the destructive phase of the hair cycle. Instead, hair follicle stem cells lose quiescence and become exhausted, and thus no stem cell niches are established i...

  11. How to Approach a Traffic Light.

    Science.gov (United States)

    Katz, J. I.

    1990-01-01

    The problem of determining the most energy-efficient strategy to use in approaching a traffic light that is sighted at an unknown phase in its cycle is discussed. Included are calculations, results, and conclusions. (KR)

  12. Effects of traffic noise

    Energy Technology Data Exchange (ETDEWEB)

    Gottlob, D.

    1986-02-01

    One of the main sources of noise is road traffic. In 1984 there were over 25 million cars, 1.2 million lorries, 1.3 million motor cycles and 1.6 million mopeds using our roads. Opinion polls showed that 21% of the population felt that they were affected by traffic noise as a nuisance factor. An outline of the effects of this noise on the affected population is given, illustrated by diagrams. Details about noise emissions (drive-past level) of the different types of vehicles in city traffic are stated and the effects of noise described. The author goes into the nuisance effect (noise is not a physical factor, but a psychosocial one), changes in behaviour (ways of speaking, reduction of stress on households in proportion to rising income and higher educational levels) and the consequences for health (the reaction of the body to noise is primarily a consequence of the psychosomatic organisation of ow bodies). In conclusion, the author deals with the subjective efficiency of noise protection measures. (HWJ).

  13. Mucociliary clearance in chronic sinusitis

    OpenAIRE

    Birdi, Surinder Mohan; Singh, Sunder; Singh, Ajit

    1998-01-01

    Mucociliary clearance is an important defence mechanism of upper and lower respiratory tracts. Any disturbance in the mechanism leads to stagnation of secretions and secondary infection with prolonged mucociliary clearance time. The present study was undertaken to establish normal mucociliary clearance time in our region and to evaluate its diagnostic and prognostic potential in chronic sinusitis of variable duration with and without obstructive diseases.

  14. Enhancing energy expenditure and enjoyment of exercise during pregnancy through the addition of brief higher intensity intervals to traditional continuous moderate intensity cycling

    OpenAIRE

    Ong, Ming Jing; Wallman, Karen E.; Fournier, Paul A.; Newnham, John P; Guelfi, Kym J

    2016-01-01

    Background Current guidelines recommend that pregnant women without contraindications should engage in 30 min or more of moderate intensity exercise on most days of the week, however, many women fail to achieve this goal. This study examined the effect of adding brief higher intensity intervals to traditional continuous moderate intensity exercise on energy expenditure and the enjoyment of exercise in late pregnancy. This is important to determine given that any additional energy expenditure ...

  15. CONTROLLING TRAFFIC FLOW IN MULTILANE-ISOLATED INTERSECTION USING ANFIS APPROACH TECHNIQUES

    OpenAIRE

    G. R. LAI; A. CHE SOH; H. MD. SARKAN; R. Z. ABDUL RAHMAN; Hassan, M. K.

    2015-01-01

    Many controllers have applied the Adaptive Neural-Fuzzy Inference System (ANFIS) concept for optimizing the controller performance. However, there are less traffic signal controllers developed using the ANFIS concept. ANFIS traffic signal controller with its fuzzy rule base and its ability to learn from a set of sample data could improve the performance of Existing traffic signal controlling system to reduce traffic congestions at most of the busy traffic intersections in city such as Kuala L...

  16. Interval Management with Spacing to Parallel Dependent Runways (IMSPIDR) Experiment and Results

    Science.gov (United States)

    Baxley, Brian T.; Swieringa, Kurt A.; Capron, William R.

    2012-01-01

    An area in aviation operations that may offer an increase in efficiency is the use of continuous descent arrivals (CDA), especially during dependent parallel runway operations. However, variations in aircraft descent angle and speed can cause inaccuracies in estimated time of arrival calculations, requiring an increase in the size of the buffer between aircraft. This in turn reduces airport throughput and limits the use of CDAs during high-density operations, particularly to dependent parallel runways. The Interval Management with Spacing to Parallel Dependent Runways (IMSPiDR) concept uses a trajectory-based spacing tool onboard the aircraft to achieve by the runway an air traffic control assigned spacing interval behind the previous aircraft. This paper describes the first ever experiment and results of this concept at NASA Langley. Pilots flew CDAs to the Dallas Fort-Worth airport using airspeed calculations from the spacing tool to achieve either a Required Time of Arrival (RTA) or Interval Management (IM) spacing interval at the runway threshold. Results indicate flight crews were able to land aircraft on the runway with a mean of 2 seconds and less than 4 seconds standard deviation of the air traffic control assigned time, even in the presence of forecast wind error and large time delay. Statistically significant differences in delivery precision and number of speed changes as a function of stream position were observed, however, there was no trend to the difference and the error did not increase during the operation. Two areas the flight crew indicated as not acceptable included the additional number of speed changes required during the wind shear event, and issuing an IM clearance via data link while at low altitude. A number of refinements and future spacing algorithm capabilities were also identified.

  17. Phagocytic Clearance in Neurodegeneration

    OpenAIRE

    Sokolowski, Jennifer D.; Mandell, James W.

    2011-01-01

    The cellular and molecular mechanisms of phagocytic clearance of apoptotic cells and debris have been intensely studied in invertebrate model organisms and in the mammalian immune system. This evolutionarily conserved process serves multiple purposes. Uncleared debris from dying cells or aggregated proteins can be toxic and may trigger exaggerated inflammatory responses. Even though apoptotic cell death and debris accumulation are key features of neurodegenerative diseases, relatively little ...

  18. Tracheobronchial clearance studies in the guinea pig

    International Nuclear Information System (INIS)

    Tracheobronchial clearance in guinea pigs exposed to relatively monodisperse aerosols was studied. Two new techniques were developed which enabled tagging of polystyrene particles with 198Au and with a fluorescent dye. A procedure was also developed to generate polystyrene particles with a vibrating orifice generator. Seventy animals were exposed via inhalation to relatively monodisperse polystyrene aerosols. Following exposure, animals were radioactively counted at regular intervals, sacrificed at predetermined times, and the lungs were removed, inflated to a standard pressure, frozen in liquid nitrogen, and freeze-dried. The freeze-dried lungs were sectioned completely, examined with a fluorescent microscope, and measurements were made of airway diameters in which particles were found. The results indicated a significant penetration of particles to the distal bronchioles and air spaces for 7.9 μm (MMD) particles and a lesser, though still significant, penetration for 10.3 μm (MMD) particles. An anatomical model for guinea pig lung morphology was used to classify particular ranges of airway diameters into zones. These zones were used to specify a compartmental model for lung clearance and the experimental particle distributions were categorized using this model. Equations were then developed describing the compartmental clearance. Rate constants were then obtained and used to predict airway transport rates in specific lung generations.The predicted transport rates ranged from approximately 0.001 mm/min in the distal bronchioles to approximately 8 mm/min in the trachea. These values agree with previous models for airway transport rates, and are consistent with experimental determinations of tracheal transport rates. Transit times were calculated and the results indicate a 24 hr clearance time for tracheobronchial clearance in the guinea pig

  19. Spectral representation of the annual cycle in the climate change signal

    OpenAIRE

    T. Bosshard; S. Kotlarski; Ewen, T.; Schär, C.

    2011-01-01

    The annual cycle of temperature and precipitation changes as projected by climate models is of fundamental interest in climate impact studies. Its estimation, however, is impaired by natural variability. Using a simple form of the delta change method, we show that on regional scales relevant for hydrological impact models, the projected changes in the annual cycle are prone to sampling artefacts. For precipitation at station locations, these artefacts may have amplitudes that are comparable t...

  20. 城市灯控平面交叉口慢行交通时空违章特征研究%Slow Traffic Peccancy Character for Urban Signal Intersection

    Institute of Scientific and Technical Information of China (English)

    王庆; 陈学武; 周娇; 陈琳英

    2012-01-01

    在南京市内4个典型交叉口调查数据的基础上,通过对4 000多个行人样本数据和相应交叉口不同时间段的自行车违章数据的统计分析,得出了慢行交通的时空违章特征.行人个体违章在时空违章上有不同的表现形式,在不同交叉口存在很大的差异性;行人的违章行为与性别无关,与年龄有关,少年的违章比例最低.由于交叉口断面形式、信号配时、运行秩序、交通管制、周边环境等方面的因素,自行车的行驶方向平均违章率和违章性质平均违章率在不同交叉口存在很大的差异性.针对慢行交通违章者安全意识淡薄且违章成本较低、交叉口的设计不合理等原因,提出相应的预防和纠正违章的建议和措施.%It has been drawn out from statistical analysis on 4000 sample data of the peccancy of passerby at different intersection from the four model intersection in Nanjing that there is different behave forms in time and space for passby peccancy and great difference at each crossings. It relates to passerby age, but not to sex, e. G. The peccancy rate of teen-age is the lowest. There is great difference in peccancy of run way and behavior property by analysis on differ time sect bicycle date, which is related to some factors, such as road cross-section, traffic control, run order and surrounding environment. According to the main reason of slow traffic peccancy behavior, I. E. The actor's dim safety consciousness, low cost of peccany, srrationali intersecton design, corresponding suggestions and measures to prevent and correct traffic peccancy are proposed. The behavior character of slow traffic peccancy on the city s signal intersection would be a good reference for solving the urban signal intersection mixed traffic problems.

  1. Synchronization of Traffic Light Systems for Maximum Efficiency along Jalan Bukit Gambier, Penang, Malaysia

    OpenAIRE

    Ahmad Rafidi M.A.; Abdul Hamid A.H.

    2014-01-01

    The synchronization of traffic light systems is one of the best solutions in order to avoid problematic traffic jams. Traffic timing is a major concern when it comes to traffic management. One of the common causes of traffic jams is because of nonsynchronized traffic light systems. Once a light turns green, traffic begins to move, but by the time the moving traffic reaches the next light, the signal is still red. This will disrupt the continuity of the traffic flow, especially for large main ...

  2. Traffic Monitoring and Control Using RFID

    Directory of Open Access Journals (Sweden)

    Gaurav Thakur

    2013-09-01

    Full Text Available Traffic congestion and tidal flow management were recognized as major problems in modern urban areas, which have caused much frustration and loss of man hours. The operation of standard traffic lights which are currently deployed in many junctions, are based on predetermined timing schemes, which are fixed during the installation and remain until further resetting. The timing is no more than a default setup to control what may be considered as normal traffic. Although every road junction by necessity requires different traffic light timing setup, many existing systems operate with a default sequence. To design an intelligent and efficient traffic control system, a number of parameters that represent the status of the road conditions must be identified and taken into consideration. Approach: In order to solve the problem an intelligent RFID traffic control has been developed. This project is based on monitoring the traffic density at the signal using RFID Reader. RFID tags which is placed (instead of number plate at each vehicle will serve as the unique number of vehicle .Reader will count the number of tags at the signal and take decision of increasing or decreasing the signal time .This reader is also use to find the violation(VIN of violator of the signal. Each passive tag will have certain number of bytes information will be different for different vehicles. Whenever any tag will approach any signal, reader will take that bytes of information and simultaneously will also increment the number of vehicles for making decision to change the signal timing. Each tag of data will be stored in main memory (database.This unique data will also help in determining the violator of the signal .Thus it will save human efforts and resources to a greater extent and reduce waiting of the people at the signal. After implementation of this project, now all people waiting at the signal will get proper time (green light according to the traffic density

  3. A new solar signal: Average maximum sunspot magnetic fields independent of activity cycle

    CERN Document Server

    Livingston, William

    2016-01-01

    Over the past five years, 2010-2015, we have observed, in the near infrared (IR), the maximum magnetic field strengths for 4145 sunspot umbrae. Herein we distinguish field strengths from field flux. (Most solar magnetographs measure flux). Maximum field strength in umbrae is co-spatial with the position of umbral minimum brightness (Norton and Gilman, 2004). We measure field strength by the Zeeman splitting of the Fe 15648.5 A spectral line. We show that in the IR no cycle dependence on average maximum field strength (2050 G) has been found +/- 20 Gauss. A similar analysis of 17,450 spots observed by the Helioseismic and Magnetic Imager onboard the Solar Dynamics Observatory reveal the same cycle independence +/- 0.18 G., or a variance of 0.01%. This is found not to change over the ongoing 2010-2015 minimum to maximum cycle. Conclude the average maximum umbral fields on the Sun are constant with time.

  4. Using the moving synchronous average to analyze fuzzy cyclostationary signals

    OpenAIRE

    Leclere, Q.; Hamzaoui, Nacer

    2014-01-01

    International audience Cyclostationarity is a property of vibration and acoustic signals recorded on rotating machines operating at constant speed. It states that the statistic properties of signals are periodic: the random process defined by the signal observed at a given position in the cycle is stationary, the cycle being defined as the angle interval between two identical configurations of the mechanical system. Cyclostationarity is not fully satisfied if the signals are acquired in the ti...

  5. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis.

    Directory of Open Access Journals (Sweden)

    Jeffrey M Skerker

    2005-10-01

    Full Text Available Two-component signal transduction systems, comprised of histidine kinases and their response regulator substrates, are the predominant means by which bacteria sense and respond to extracellular signals. These systems allow cells to adapt to prevailing conditions by modifying cellular physiology, including initiating programs of gene expression, catalyzing reactions, or modifying protein-protein interactions. These signaling pathways have also been demonstrated to play a role in coordinating bacterial cell cycle progression and development. Here we report a system-level investigation of two-component pathways in the model organism Caulobacter crescentus. First, by a comprehensive deletion analysis we show that at least 39 of the 106 two-component genes are required for cell cycle progression, growth, or morphogenesis. These include nine genes essential for growth or viability of the organism. We then use a systematic biochemical approach, called phosphotransfer profiling, to map the connectivity of histidine kinases and response regulators. Combining these genetic and biochemical approaches, we identify a new, highly conserved essential signaling pathway from the histidine kinase CenK to the response regulator CenR, which plays a critical role in controlling cell envelope biogenesis and structure. Depletion of either cenK or cenR leads to an unusual, severe blebbing of cell envelope material, whereas constitutive activation of the pathway compromises cell envelope integrity, resulting in cell lysis and death. We propose that the CenK-CenR pathway may be a suitable target for new antibiotic development, given previous successes in targeting the bacterial cell wall. Finally, the ability of our in vitro phosphotransfer profiling method to identify signaling pathways that operate in vivo takes advantage of an observation that histidine kinases are endowed with a global kinetic preference for their cognate response regulators. We propose that this

  6. Characteristics of vehicular traffic flow at a roundabout

    Science.gov (United States)

    Ebrahim Fouladvand, M.; Sadjadi, Zeinab; Reza Shaebani, M.

    2004-10-01

    We construct a stochastic cellular automata model for the description of vehicular traffic at a roundabout designed at the intersection of two perpendicular streets. The vehicular traffic is controlled by a self-organized scheme in which traffic lights are absent. This controlling method incorporates a yield-at-entry strategy for the approaching vehicles to the circulating traffic flow in the roundabout. Vehicular dynamics is simulated and the delay experienced by the traffic at each individual street is evaluated. We discuss the impact of the geometrical properties of the roundabout on the total delay. We compare our results with traffic-light signalization schemes, and obtain the critical traffic volume over which the intersection is optimally controlled through traffic-light signalization schemes.

  7. OPTIMIZATION OF URBAN MULTI-INTERSECTION TRAFFIC FLOW VIA Q-LEARNING

    OpenAIRE

    Yit Kwong Chin; Heng Jin Tham; N.S.V. Kameswara Rao; Nurmin Bolong; Kenneth Tze Kin Teo

    2013-01-01

    Congestions of the traffic flow within the urban traffic network have been a challenging task for all the urban developers. Many approaches have been introduced into the current system to solve the traffic congestion problems. Reconfiguration of the traffic signal timing plan has been carried out through implementation of different techniques. However, dynamic characteristics of the traffic flow increase the difficulties towards the ultimate solutions. Thus, traffic congestions still remain a...

  8. A Sarsa(λ)-Based Control Model for Real-Time Traffic Light Coordination

    OpenAIRE

    Xiaoke Zhou; Fei Zhu; Quan Liu; Yuchen Fu; Wei Huang

    2014-01-01

    Traffic problems often occur due to the traffic demands by the outnumbered vehicles on road. Maximizing traffic flow and minimizing the average waiting time are the goals of intelligent traffic control. Each junction wants to get larger traffic flow. During the course, junctions form a policy of coordination as well as constraints for adjacent junctions to maximize their own interests. A good traffic signal timing policy is helpful to solve the problem. However, as there are so many factors t...

  9. Site clearance working group

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The Gulf of Mexico and Louisiana continue to be areas with a high level of facility removal, and the pace of removal is projected to increase. Regulations were promulgated for the Gulf of Mexico and Louisiana requiring that abandoned sites be cleared of debris that could interfere with fishing and shrimping activities. The site clearance regulations also required verification that the sites were clear. Additionally, government programs were established to compensate fishermen for losses associated with snagging their equipment on oil and gas related objects that remained on the water bottoms in areas other than active producing sites and sites that had been verified as clear of obstructions and snags. The oil and gas industry funds the compensation programs. This paper reviews the regulations and evolving operating practices in the Gulf of Mexico and Louisiana where site clearance and fisherman`s gear compensation regulations have been in place for a number of years. Although regulations and guidelines may be in place elsewhere in the world, this paper focuses on the Gulf of Mexico and Louisiana. Workshop participants are encouraged to bring up international issues during the course of the workshop. Additionally, this paper raises questions and focuses on issues that are of concern to the various Gulf of Mexico and Louisiana water surface and water bottom stakeholders. This paper does not have answers to the questions or issues. During the workshop participants will debate the questions and issues in an attempt to develop consensus opinions and/or make suggestions that can be provided to the appropriate organizations, both private and government, for possible future research or policy adjustments. Site clearance and facility removal are different activities. Facility removal deals with removal of the structures used to produce oil and gas including platforms, wells, casing, piles, pipelines, well protection structures, etc.

  10. Jamitons: Phantom Traffic Jams

    Science.gov (United States)

    Kowszun, Jorj

    2013-01-01

    Traffic on motorways can slow down for no apparent reason. Sudden changes in speed by one or two drivers can create a chain reaction that causes a traffic jam for the vehicles that are following. This kind of phantom traffic jam is called a "jamiton" and the article discusses some of the ways in which traffic engineers produce…

  11. Characterization of mortality rates resulting from traffic accidents involving cycles Caracterización de la mortalidad por accidentes del tránsito con participación de ciclos

    Directory of Open Access Journals (Sweden)

    Mavis Ortis Sagasta

    2010-08-01

    Full Text Available Background: Traffic accidents are a highly complex phenomenon due to the variety of factors involved in their occurrence. They have become more relevant as the fight against illnesses becomes more effective. Objective: To characterize the mortality rates resulting from traffic accidents involving cycles. Methods: Descriptive study on case series conducted at the General University Hospital "Dr. Gustavo Lima Aldereguía " in Cienfuegos on all deaths related to traffic accidents involving cycles from January 1st to December 31st , 2009. Variables that were analyzed: age, sex, time of the accident, predominantly affected anatomical region, direct cause of death and ingestion of alcohol. Results: There were 26 deaths (6.4 per 100 000 inhabitants, mainly in the group from 15 to 29 years old, predominantly males with 23 cases (88.4%.53, 8% of them were workers and 23% were students. There was a predominance of fatalities in the hours between 6:00 pm and 11:59 pm. The most affected anatomic region was the head (61.5%, 46, 2 % of deaths had more than 50 mg of alcohol in blood and the predominant direct cause of death was the injuries of higher nervous centers. Conclusions: Traffic accidents involving cycles are more frequent in young males . They are related to the ingestion of alcohol and usually affect the head region.Introducción: los accidentes constituyen un fenómeno sumamente complejo debido a los numerosos y variados factores que intervienen en su producción. Estos se hacen más relevantes en la medida que se hace más eficaz la lucha contra las enfermedades. Objetivo: caracterizar la mortalidad por accidentes de tránsito con participación de ciclos. Métodos: estudio descriptivo de serie de casos, realizado en el Hospital General Universitario “Dr. Gustavo Aldereguía Lima” de Cienfuegos sobre todos los

  12. Influence of Link Flow and Traffic Signal Control on the Forecast of Travel Time%流量和信号控制对运行时间预测的影响

    Institute of Scientific and Technical Information of China (English)

    徐丽群; 杨兆升; 管德永

    2001-01-01

    通过对实际交通状况的分析,说明路线运行时间不仅是路线交通流量的函数,而且是由于交叉口信号控制引起延误的函数。%The use of ATIS (Advanced Traveler Information Systems) for urban traffic management means that tripmakers can get in real time the pre-trip information and en-route information to ch oose the optimal route and reduce their travel time. Hence, reliable and frequently updated travel time information is the basis of effec tive implementation of ATIS. This paper proposes the method of foreca sting travel time at signalized network and concludes that travel time is not only the function of flow but also the function of delay caused by signal control at intersection.

  13. Nucleotide-mediated airway clearance.

    Science.gov (United States)

    Schmid, Andreas; Clunes, Lucy A; Salathe, Mathias; Verdugo, Pedro; Dietl, Paul; Davis, C William; Tarran, Robert

    2011-01-01

    A thin layer of airway surface liquid (ASL) lines the entire surface of the lung and is the first point of contact between the lung and the environment. Surfactants contained within this layer are secreted in the alveolar region and are required to maintain a low surface tension and to prevent alveolar collapse. Mucins are secreted into the ASL throughout the respiratory tract and serve to intercept inhaled pathogens, allergens and toxins. Their removal by mucociliary clearance (MCC) is facilitated by cilia beating and hydration of the ASL by active ion transport. Throughout the lung, secretion, ion transport and cilia beating are under purinergic control. Pulmonary epithelia release ATP into the ASL which acts in an autocrine fashion on P2Y(2) (ATP) receptors. The enzymatic network describes in Chap. 2 then mounts a secondary wave of signaling by surface conversion of ATP into adenosine (ADO), which induces A(2B) (ADO) receptor-mediated responses. This chapter offers a comprehensive description of MCC and the extensive ramifications of the purinergic signaling network on pulmonary surfaces. PMID:21560046

  14. Traffic Route Modelling and Assignment with Intelligent Transport System

    OpenAIRE

    Kunicina Nadezhda; Galkina Alina; Zabasta Anatolijs; Patlins Antons; Kondratjevs Kaspars

    2014-01-01

    The development of signal transmitting environment for multimodal traffic control will enhance the integration of emergency and specialized transport routing tools in usual traffic control paradigms - it is one of the opportunities offered by modern intelligent traffic control systems. The improvement of effective electric power use in public transport system is an advantage of Intelligent Transport System (ITS). The research is connected with the improvement of on-line traffic control and ad...

  15. Study on Driver Visual Physiological Characteristics in Urban Traffic

    OpenAIRE

    Fengyuan Wang; Min Li; Jieyu Fan; Fuquan Pan

    2014-01-01

    In the integrated traffic environment, human factor is always a main factor of the three elementary factors, besides the vehicle and road factor. The driver physiological and psychological characteristics have an important impact especially on traffic safety in urban road traffic conditions . Some typical traffic scenes in condition of urban road, such as light signal control at intersection, overtaking, and passing, are selected for condition analysis. An eye movement apparatus was used to o...

  16. Data Fusion in Road Traffic Engineering: An overview

    OpenAIRE

    EL-FAOUZI, NE

    2004-01-01

    The objective of this paper is to present an analysis of recent applications of data fusion (DF) in road traffic engineering. First, we report the most significant applications of data fusion techniques in road traffic engineering area: traffic monitoring, signal control, Automatic Incident Detection, traffic forecasting, Intelligent Transportation Systems ..., as well as the extent and direction of DF interest in the field. Second, a classification including applications, fusion goalsand mat...

  17. REAL TIME TRAFFIC LIGHT CONTROL USING IMAGE PROCESSING

    OpenAIRE

    PALLAVI CHOUDEKAR,; SAYANTI BANERJEE,; M.K.MUJU

    2011-01-01

    As the problem of urban traffic congestion spreads, there is a pressing need for the introduction of advanced technology and equipment to improve the state-of-the-art of traffic control. Traffic problems nowadays are increasing because of the growing number of vehicles and the limited resources provided by current nfrastructures. The simplest way for controlling a traffic light uses timer for each phase. Another way is to use electronic sensors in order to detect vehicles, and produce signal...

  18. G-quadruplex − based homogenous fluorescence platform for ultrasensitive DNA detection through isothermal cycling and cascade signal amplification

    International Nuclear Information System (INIS)

    We describe a simple and homogenous fluorimetric method for sensitive determination of DNA. It is based on target-triggered isothermal cycling and a cascade exponential amplification reaction that generates a large amount of a G-quadruplex. This results in strong fluorescence signal when using thioflavin T as a G-quadruplex-specific light-up fluorescent probe. Tedious handling after amplification is widely eliminated by the addition of thioflavin T. No other exogenous reagent is required. This detection platform is inexpensive and rapid, and displays high sensitivity for target DNA, with a detection limit as low as 91 pM. (author)

  19. Vehicular traffic flow at an intersection with the possibility of turning

    Science.gov (United States)

    Ebrahim Foulaadvand, M.; Belbasi, Somayyeh

    2011-03-01

    We have developed a Nagel-Schreckenberg cellular automata model for describing a vehicular traffic flow at a single intersection. A set of traffic lights operating in a fixed-time scheme controls the traffic flow. An open boundary condition is applied to the streets each of which conducts a unidirectional flow. Streets are single lane and cars can turn upon reaching to the intersection with prescribed probabilities. Extensive Monte Carlo simulations are carried out to find the model flow characteristics. In particular, we investigate the flow dependence on signalization parameters, turning probabilities and input rates. It is shown that for each set of parameters, there exists a plateau region inside which the total outflow from the intersection remains almost constant. We also compute total waiting time of vehicles per cycle behind red lights for various control parameters.

  20. Family study of antipyrine clearance.

    OpenAIRE

    Blain, P G; Mucklow, J C; Wood, P; Roberts, D F; Rawlins, M D

    1982-01-01

    Antipyrine clearance was measured in 208 healthy volunteers from 78 families. After the values had been corrected for weight and sex, antipyrine clearance was observed to be significantly correlated between siblings (r = 0.590) and between spouses (r = 0.320), but not between parents and their offspring. After the clearance values had been corrected for tobacco and oral contraceptive use, there was still no significant correlation between parents and offspring. These results are incompatible ...

  1. TRANSIMS traffic flow characteristics

    OpenAIRE

    Nagel, Kai; Stretz, Paula; Pieck, Martin; Donnelly, Rick; Barrett, Christopher L.

    1997-01-01

    Knowledge of fundamental traffic flow characteristics of traffic simulation models is an essential requirement when using these models for the planning, design, and operation of transportation systems. In this paper we discuss the following: a description of how features relevant to traffic flow are currently under implementation in the TRANSIMS microsimulation, a proposition for standardized traffic flow tests for traffic simulation models, and the results of these tests for two different ve...

  2. Anti-cancer activity of Tonglian decoction against esophageal cancer cell proliferation through regulation of the cell cycle and PI3K/Akt signaling pathway

    Directory of Open Access Journals (Sweden)

    Yongsen Jia

    2015-04-01

    Conclusion: TD could inhibit EC9706 carcinoma cell proliferation by blocking the cell cycle progression in S phase. The possible mechanism was inhibition of multiple targets in the PI3K/Akt signaling pathway by TD.

  3. SQUID–SIMS is a useful approach to uncover primary signals in the Archean sulfur cycle

    OpenAIRE

    Fischer, Woodward W.; Fike, David A; Johnson, Jena E; Raub, Timothy D; Guan, Yunbin; Kirschvink, Joseph L; Eiler, John M.

    2014-01-01

    The Agouron Institute and National Aeronautic and Space Administration Exobiology Award NNX09AM91G supported this work. Many aspects of Earth's early sulfur cycle, from the origin of mass-anomalous fractionations to the degree of biological participation, remain poorly understood-in part due to complications from postdepositional diagenetic and metamorphic processes. Using a combination of scanning high-resolution magnetic superconducting quantum interference device (SQUID) microscopy and ...

  4. Load characterization and anomaly detection for voice over IP traffic.

    Science.gov (United States)

    Mandjes, Michel; Saniee, Iraj; Stolyar, Alexander L

    2005-09-01

    We consider the problem of traffic anomaly detection in IP networks. Traffic anomalies typically arise when there is focused overload or when a network element fails and it is desired to infer these purely from the measured traffic. We derive new general formulae for the variance of the cumulative traffic over a fixed time interval and show how the derived analytical expression simplifies for the case of voice over IP traffic, the focus of this paper. To detect load anomalies, we show it is sufficient to consider cumulative traffic over relatively long intervals such as 5 min. We also propose simple anomaly detection tests including detection of over/underload. This approach substantially extends the current practice in IP network management where only the first-order statistics and fixed thresholds are used to identify abnormal behavior. We conclude with the application of the scheme to field data from an operational network. PMID:16252813

  5. Implementation of Neural Network with a variant of Turing Machine for Traffic Flow Control

    Directory of Open Access Journals (Sweden)

    Rashmi Sehrawat

    2013-05-01

    Full Text Available The conventional method of operation of a typical traffic light is to distribute the time equally for all the directions.This method causes congestion when throughput of the signal increases and is alsoineffective in managing traffic flow. In this paper, we have proposed a new model for managing traffic intelligently.The model is based on Turing machine with the application of neural network. The modelconsiders current traffic status of its own signal along with the status of its adjacent signals to determine the ratio of time slot for each signal therefore, reducing traffic congestion to a greater extent and ensuring steady flow of traffic in a wide region.

  6. A traffic situation analysis system

    Science.gov (United States)

    Sidla, Oliver; Rosner, Marcin

    2011-01-01

    The observation and monitoring of traffic with smart visions systems for the purpose of improving traffic safety has a big potential. For example embedded vision systems built into vehicles can be used as early warning systems, or stationary camera systems can modify the switching frequency of signals at intersections. Today the automated analysis of traffic situations is still in its infancy - the patterns of vehicle motion and pedestrian flow in an urban environment are too complex to be fully understood by a vision system. We present steps towards such a traffic monitoring system which is designed to detect potentially dangerous traffic situations, especially incidents in which the interaction of pedestrians and vehicles might develop into safety critical encounters. The proposed system is field-tested at a real pedestrian crossing in the City of Vienna for the duration of one year. It consists of a cluster of 3 smart cameras, each of which is built from a very compact PC hardware system in an outdoor capable housing. Two cameras run vehicle detection software including license plate detection and recognition, one camera runs a complex pedestrian detection and tracking module based on the HOG detection principle. As a supplement, all 3 cameras use additional optical flow computation in a low-resolution video stream in order to estimate the motion path and speed of objects. This work describes the foundation for all 3 different object detection modalities (pedestrians, vehi1cles, license plates), and explains the system setup and its design.

  7. The digital traces of bubbles: feedback cycles between socio-economic signals in the Bitcoin economy

    OpenAIRE

    David Garcia; Claudio Juan Tessone; Pavlin Mavrodiev; Nicolas Perony

    2014-01-01

    What is the role of social interactions in the creation of price bubbles? Answering this question requires obtaining collective behavioural traces generated by the activity of a large number of actors. Digital currencies offer a unique possibility to measure socio-economic signals from such digital traces. Here, we focus on Bitcoin, the most popular cryptocurrency. Bitcoin has experienced periods of rapid increase in exchange rates (price) followed by sharp decline; we hypothesise that these ...

  8. The digital traces of bubbles: feedback cycles between socio-economic signals in the Bitcoin economy.

    Science.gov (United States)

    Garcia, David; Tessone, Claudio J; Mavrodiev, Pavlin; Perony, Nicolas

    2014-10-01

    What is the role of social interactions in the creation of price bubbles? Answering this question requires obtaining collective behavioural traces generated by the activity of a large number of actors. Digital currencies offer a unique possibility to measure socio-economic signals from such digital traces. Here, we focus on Bitcoin, the most popular cryptocurrency. Bitcoin has experienced periods of rapid increase in exchange rates (price) followed by sharp decline; we hypothesize that these fluctuations are largely driven by the interplay between different social phenomena. We thus quantify four socio-economic signals about Bitcoin from large datasets: price on online exchanges, volume of word-of-mouth communication in online social media, volume of information search and user base growth. By using vector autoregression, we identify two positive feedback loops that lead to price bubbles in the absence of exogenous stimuli: one driven by word of mouth, and the other by new Bitcoin adopters. We also observe that spikes in information search, presumably linked to external events, precede drastic price declines. Understanding the interplay between the socio-economic signals we measured can lead to applications beyond cryptocurrencies to other phenomena that leave digital footprints, such as online social network usage. PMID:25100315

  9. The digital traces of bubbles: feedback cycles between socio-economic signals in the Bitcoin economy

    Science.gov (United States)

    Garcia, David; Tessone, Claudio J.; Mavrodiev, Pavlin; Perony, Nicolas

    2014-01-01

    What is the role of social interactions in the creation of price bubbles? Answering this question requires obtaining collective behavioural traces generated by the activity of a large number of actors. Digital currencies offer a unique possibility to measure socio-economic signals from such digital traces. Here, we focus on Bitcoin, the most popular cryptocurrency. Bitcoin has experienced periods of rapid increase in exchange rates (price) followed by sharp decline; we hypothesize that these fluctuations are largely driven by the interplay between different social phenomena. We thus quantify four socio-economic signals about Bitcoin from large datasets: price on online exchanges, volume of word-of-mouth communication in online social media, volume of information search and user base growth. By using vector autoregression, we identify two positive feedback loops that lead to price bubbles in the absence of exogenous stimuli: one driven by word of mouth, and the other by new Bitcoin adopters. We also observe that spikes in information search, presumably linked to external events, precede drastic price declines. Understanding the interplay between the socio-economic signals we measured can lead to applications beyond cryptocurrencies to other phenomena that leave digital footprints, such as online social network usage. PMID:25100315

  10. Design and Development of Sensor Based Traffic Light System

    Directory of Open Access Journals (Sweden)

    A. Albagul

    2006-01-01

    Full Text Available The main object of this study was to design and implement a suitable algorithm and its simulation for an intelligent traffic signal simulator. The system developed is able to sense the presence or absence of vehicles within certain range by setting the appropriate duration for the traffic signals to react accordingly. By employing mathematical functions to calculate the appropriate timing for the green signal to illuminate, the system can help to solve the problem of traffic congestion. The simulation of the algorithm of the traffic signal system was done using MATLAB software. Hardware simulation tests were successfully performed on the algorithm implemented into a controller. The new timing scheme that was implemented promises an improvement in the current traffic light system and this system is feasible, affordable and ready to be implemented especially during peak hours. A countdown timer interfacing according to the traffic system using Lab VIEW software was also created.

  11. A Marine Traffic Flow Model

    OpenAIRE

    Tsz Leung Yip

    2013-01-01

    A model is developed for studying marine traffic flow through classical traffic flow theories, which can provide us with a better understanding of the phenomenon of traffic flow of ships. On one hand, marine traffic has its special features and is fundamentally different from highway, air and pedestrian traffic. The existing traffic models cannot be simply extended to marine traffic without addressing marine traffic features. On the other hand, existing literature on marine traffic focuses on...

  12. SELF-SIMILAR TRAFFIC GENERATOR

    OpenAIRE

    Linawati Linawati; I Made Suartika

    2009-01-01

    Network traffic generator can be produced using OPNET. OPNET generates the traffic as explicit traffic or background traffic. This paper demonstrates generating traffic in OPNET 7.0 as background traffic. The traffi generator that was simulated is self-similar traffic with different Hurst parameter. The simulation results proved that OPNET with background traffic function can be as a qualified self-similar traffic generator. These results can help in investigating and analysing network perfor...

  13. Intervenção comunitária para prevenção de acidentes de trânsito entre trabalhadores ciclistas Intervención comunitaria para la prevención de accidentes de tránsito entre trabajadores ciclistas A community intervention to prevent traffic accidents among bicycle commuters

    Directory of Open Access Journals (Sweden)

    Giancarlo Bacchieri

    2010-10-01

    intervención educacional de prevención de accidentes de tránsito con trabajadores que utilizan la bicicleta como modo de transporte. MÉTODOS: Estudio de intervención, longitudinal, con implementación escalonada, realizado en cinco urbanizaciones con características geográficas distintas en la ciudad de Pelotas, Sur de Brasil, de enero de 2006 a mayo de 2007. Fueron sorteados 42 sectores censados de dichas urbanizaciones. Todos los domicilios fueron visitados en búsqueda de trabajadores del sexo masculino que utilizasen la bicicleta como modo de transporte, resultando en una muestra de 1.133 individuos. Fueron analizados como resultados "accidentes de tránsito" y "casi-accidentes". Mensualmente, vía telefónica, los ciclistas eran interrogados con respecto a la ocurrencia de accidentes de tránsito y de "casi-accidentes". Quincenalmente, a partir del segundo mes de acompañamiento, un grupo de aproximadamente 60 ciclistas era convidado a participar de la intervención, que incluía un componente educativo (seminario y presentación de video educativo, distribución de un kit de seguridad (chaleco nocturno con reflexivo, cartilla educativa y cintas reflexivas y revisión de los frenos de la bicicleta (mantenimiento realizado al ser necesario. Regresión de Poisson, con ajuste para el efecto del tiempo, fue utilizada para medir el efecto de la intervención. RESULTADOS: Aproximadamente 45% de los ciclistas no comparecieron a la intervención. Durante el período de estudio, 9% de los individuos informaron un accidente de tránsito y 88% un casi-accidente. En total, ocurrieron 106 accidentes y 1.091 casi-accidentes. No fue observado efecto de la intervención en ambos resultados. CONCLUSIONES: La intervención propuesta no fue capaz de reducir accidentes entre trabajadores ciclistas. falta de interés en seguridad por parte de los ciclistas y factores externos, tales como infra-estructura de las vías y comportamiento de los choferes, pueden haber colaborado para ese

  14. Reforming Customs Clearance in Pakistan

    OpenAIRE

    Ahmad, Manzoor

    2010-01-01

    Simple, fast, transparent customs clearance procedures encourage trade-and the resulting tariffs and related taxes raise government revenue and stimulate economic development. After outsourcing failed to make customs more efficient or increase revenue, in 2002 Pakistan began pursuing a modern single window system for customs clearance. In 2005 the system was introduced at the port of Karac...

  15. RATIONAL CUSTOMS CLEARANCE TECHNOLOGY CHOICE

    OpenAIRE

    Shramenko, N.; Andriets, V.

    2008-01-01

    Issues concerning cargo delivery efficiencyincrease by choice of rational customs clearance technology have been considered. Three possible variants of customs clearance andmethods which allow to define the most rational version of cargo delivery in international road communication based on main efficiency criteria for definite distance have been presented.

  16. Turbomachinery Clearance Control

    Science.gov (United States)

    Chupp, Raymond E.; Hendricks, Robert C.; Lattime, Scott B.; Steinetz, Bruce M.; Aksit, Mahmut F.

    2007-01-01

    Controlling interface clearances is the most cost effective method of enhancing turbomachinery performance. Seals control turbomachinery leakages, coolant flows and contribute to overall system rotordynamic stability. In many instances, sealing interfaces and coatings are sacrificial, like lubricants, giving up their integrity for the benefit of the component. They are subjected to abrasion, erosion, oxidation, incursive rubs, foreign object damage (FOD) and deposits as well as extremes in thermal, mechanical, aerodynamic and impact loadings. Tribological pairing of materials control how well and how long these interfaces will be effective in controlling flow. A variety of seal types and materials are required to satisfy turbomachinery sealing demands. These seals must be properly designed to maintain the interface clearances. In some cases, this will mean machining adjacent surfaces, yet in many other applications, coatings are employed for optimum performance. Many seals are coating composites fabricated on superstructures or substrates that are coated with sacrificial materials which can be refurbished either in situ or by removal, stripping, recoating and replacing until substrate life is exceeded. For blade and knife tip sealing an important class of materials known as abradables permit blade or knife rubbing without significant damage or wear to the rotating element while maintaining an effective sealing interface. Most such tip interfaces are passive, yet some, as for the high-pressure turbine (HPT) case or shroud, are actively controlled. This work presents an overview of turbomachinery sealing. Areas covered include: characteristics of gas and steam turbine sealing applications and environments, benefits of sealing, types of standard static and dynamics seals, advanced seal designs, as well as life and limitations issues.

  17. Effects of activated fibroblasts on phenotype modulation, EGFR signalling and cell cycle regulation in OSCC cells

    International Nuclear Information System (INIS)

    Crosstalk between carcinoma associated fibroblasts (CAFs) and oral squamous cell carcinoma (OSCC) cells is suggested to mediate phenotype transition of cancer cells as a prerequisite for tumour progression, to predict patients’ outcome, and to influence the efficacy of EGFR inhibitor therapies. Here we investigate the influence of activated fibroblasts as a model for CAFs on phenotype and EGFR signalling in OSCC cells in vitro. For this, immortalised hTERT-BJ1 fibroblasts were activated with TGFβ1 and PDGFAB to generate a myofibroblast or proliferative phenotype, respectively. Conditioned media (FCMTGF, FCMPDGF) were used to stimulate PE/CA-PJ15 OSCC cells. Results were compared to the effect of conditioned media of non-stimulated fibroblasts (FCMB). FCMTGF stimulation leads to an up-regulation of vimentin in the OSCC cells and an enhancement of invasive behaviour, indicating EMT-like effects. Similarly, FCMTGF≫FCMPDGF induced up-regulation of EGFR, but not of ErbB2/ErbB3. In addition, we detected an increase in basal activities of ERK, PI3K/Akt and Stat3 (FCMTGF>FCMPDGF) accompanied by protein interaction of vimentin with pERK. These effects are correlated with an increased proliferation. In summary, our results suggest that the activated myofibroblast phenotype provides soluble factors which are able to induce EMT-like phenomena and to increase EGFR signalling as well as cell proliferation in OSCC cells. Our results indicate a possible influence of activated myofibroblasts on EGFR-inhibitor therapy. Therefore, CAFs may serve as promising novel targets for combined therapy strategies. - Highlights: • A cell culture model for cancer associated fibroblasts is described. • The mutual interaction with OSCC cells leads to up-regulation of EGFR in tumour cells. • mCAF induces EGFR downstream signalling with increased proliferation in OSCC. • Erk activation is associated with protein interaction with vimentin as sign of EMT. • Results qualify CAF as

  18. The influence of body posture on lithium clearance

    DEFF Research Database (Denmark)

    Kamper, A L; Strandgaard, S; Holstein-Rathlou, N H; Munck, O; Leyssac, P P

    1988-01-01

    measured four times at 1-week intervals: two in the supine and one in the sitting position, and one when the subject was walking around. Glomerular filtration rate was not influenced by posture changes. On the contrary, lithium clearance, which in the supine position was 30 +/- 9 ml/min (1 SD), tended to...... during moderate physical activity. Hence, when renal tubular function is studied with the lithium clearance method, standardization of posture and physical activity is important. In such studies physical activity such as walking should particularly be avoided....

  19. SKF95365 induces apoptosis and cell-cycle arrest by disturbing oncogenic Ca2+ signaling in nasopharyngeal carcinoma cells

    Directory of Open Access Journals (Sweden)

    Zhang J

    2015-10-01

    Full Text Available Jinyan Zhang,1 Jiazhang Wei,2 Qian He,3 Yan Lin,1 Rong Liang,1 Jiaxiang Ye,1 Zhe Zhang,4 Yongqiang Li1 1Department of Medical Oncology, Affiliated Cancer Hospital of Guangxi Medical University, 2Department of Otolaryngology-Head and Neck Oncology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China; 3Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan; 4Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China Background: Aberrant modulation of store-operated calcium ions (Ca2+ entry promotes the progression of human malignancies. Previously, we reported that the blockage of store-operated Ca2+ entry inhibited epidermal growth factor (EGF-stimulated migration and distant metastasis in nasopharyngeal carcinoma (NPC cells. However, the effects of pharmacological blocker on other Ca2+ signaling-regulated malignant characteristics in NPC cells remained poorly understood. Methods: We examined the effects of SKF96365, an inhibitor of store-operated Ca2+ channel, on EGF-launched Ca2+ signaling in two NPC cell lines. We determined the effects of SKF96365 on cell proliferation, colony formation, apoptosis, and cell-cycle status in vitro. We further elucidated the antitumor activity of SKF96365 in xenograft-bearing mice. Results: It was found that SKF96365 disturbed the thapsigargin (TG-stimulated Ca2+ release from endoplasmic reticulum and the subsequent Ca2+ influx. SKF96365 alone stimulated Ca2+ responses merely due to endoplasmic reticulum-released Ca2+. SKF96365 promoted cell mortality, inhibited colony formation, and induced apoptosis and cell-cycle arrest, while blunting the EGF-evoked Ca2+ signaling. Furthermore, we confirmed that SKF96365 reduced NPC xenograft growth while activating caspase-7-related apoptotic pathway. Conclusion: SKF96365 exerts multiple antitumor

  20. The digital traces of bubbles: feedback cycles between socio-economic signals in the Bitcoin economy

    CERN Document Server

    Garcia, David; Mavrodiev, Pavlin; Perony, Nicolas

    2014-01-01

    What is the role of social interactions in the creation of price bubbles? Answering this question requires obtaining collective behavioural traces generated by the activity of a large number of actors. Digital currencies offer a unique possibility to measure socio-economic signals from such digital traces. Here, we focus on Bitcoin, the most popular cryptocurrency. Bitcoin has experienced periods of rapid increase in exchange rates (price) followed by sharp decline; we hypothesise that these fluctuations are largely driven by the interplay between different social phenomena. We thus quantify four socio-economic signals about Bitcoin from large data sets: price on on-line exchanges, volume of word-of-mouth communication in on-line social media, volume of information search, and user base growth. By using vector autoregression, we identify two positive feedback loops that lead to price bubbles in the absence of exogenous stimuli: one driven by word of mouth, and the other by new Bitcoin adopters. We also observ...

  1. OPTIMIZATION OF URBAN MULTI-INTERSECTION TRAFFIC FLOW VIA Q-LEARNING

    Directory of Open Access Journals (Sweden)

    Yit Kwong Chin

    2013-01-01

    Full Text Available Congestions of the traffic flow within the urban traffic network have been a challenging task for all the urban developers. Many approaches have been introduced into the current system to solve the traffic congestion problems. Reconfiguration of the traffic signal timing plan has been carried out through implementation of different techniques. However, dynamic characteristics of the traffic flow increase the difficulties towards the ultimate solutions. Thus, traffic congestions still remain as unsolvable problems to the current traffic control system. In this study, artificial intelligence method has been introduced in the traffic light system to alter the traffic signal timing plan to optimize the traffic flows. Q-learning algorithm in this study has enhanced the traffic light system with learning ability. The learning mechanism of Q-learning enables traffic light intersections to release itself from traffic congestions situation. Adjacent traffic light intersections will work independently and yet cooperate with each others to a common goal of ensuring the fluency of the traffic flows within the traffic network. The simulated results show that the Q-Learning algorithm is able to learn from the dynamic traffic flow and optimize the traffic flow accordingly.

  2. CD47-SIRPα在人类红细胞老化与吞噬过程中的作用%Role of CD47-SIRPa signaling in the senescence and clearance of human red blood cells

    Institute of Scientific and Technical Information of China (English)

    周洁; 李勤; 朱自严

    2011-01-01

    探讨CD47-SIRPα在人类红细胞衰老与吞噬过程中的作用.采用Western blot检测体外4℃和37℃保存红细胞(RBC)及老化过程中红细胞膜上CD47的表达量;用单核细胞单层分析试验(monocyte monolayer assay,MMA)观察人THP-1单核细胞系对不同年龄段红细胞和CD47抗体F(ab')2端封闭红细胞的吞噬情况及Western blot检测THP-1细胞上SIRPa磷酸化情况.结果发现,无论是在体内老化还是体外老化过程中,红细胞膜上CD47的表达最均出现显著下降趋势,随着保存时间的延长,CD47的表达量最大可下降82.64%(4℃保存情况下);THP-1细胞对不同年龄段红细胞的吞噬情况存在差异性,更易吞噬年老红细胞,吞噬率为35.32,对年轻红细胞的吞噬率为13.72%(n=7,P<0.02);对新鲜红细胞的吞噬率为2.22 %,对CD47抗体F(ab')2端封闭红细胞的吞噬率为31.51%(n=7,P<0.02);吞噬不同年龄段红细胞后,THP-1细胞上磷酸化SIRPα量不同,与吞噬年轻红细胞相比,吞噬年老红细胞后,磷酸化SIRPα的量下降了57.12%.表明人类红细胞的老化与吞噬过程和CD47-SIRPα相互作用存在密切关系.%To investigate the role of CD47-SIRPa signaling in the course of the senescence and clearance of human red blood cells (RBCs) , the expression of CD47 on the membrane of RBCs stored at 4 'C or 37 'C in vitro and in vivo was detected by means of Western blot assay. The monocyte monolayer assay (MMA) was used to determine the difference of phagocytosis of THP-1 cells to RBCs with different ages(young or aged RBCs) and RBCs blocked with F(ab')2 fragments of anti-CD47 monoclonal antibody. In addition, Western blot assay was also applied to detect the expression of SIRPa phosphorylation on THP-1 cells phagocytosing the different age RBCs. It was demonstrated that the expression of CD47 on the cell membrane of human RBCs was significantly reduced both in vivo and in vitro, and along with the prolongation of the storage time of cells, the

  3. Cycling across borders

    Directory of Open Access Journals (Sweden)

    Jože Kos

    1999-01-01

    Full Text Available The article describes the intent and content of the international Velo-City conference 1999, Maribor–Graz and the organisation of this cycling development planning meeting. It focuses on the resolution of the conference concerning cycling traffic policies, the emerging network of European cycling connections and the traffic planning workshop about a difficult square in Maribor. The content framework of particular papers is shown, as well as other post-conference events. In the conclusion certain useful addresses for obtaining added data on sustainable traffic planning are given.

  4. Effects of activated fibroblasts on phenotype modulation, EGFR signalling and cell cycle regulation in OSCC cells

    Energy Technology Data Exchange (ETDEWEB)

    Berndt, Alexander, E-mail: alexander.berndt@med.uni-jena.de [Center for Molecular Biomedicine, Institute of Pathology, Jena University Hospital, 07740 Jena (Germany); Büttner, Robert, E-mail: Robert-Buettner@gmx.net [Institute of Biochemistry and Biophysics, Friedrich Schiller University Jena, 07740 Jena (Germany); Gühne, Stefanie, E-mail: stefanie_guehne@gmx.net [Center for Molecular Biomedicine, Institute of Pathology, Jena University Hospital, 07740 Jena (Germany); Gleinig, Anna, E-mail: annagleinig@yahoo.com [Center for Molecular Biomedicine, Institute of Pathology, Jena University Hospital, 07740 Jena (Germany); Richter, Petra, E-mail: P.Richter@med.uni-jena.de [Center for Molecular Biomedicine, Institute of Pathology, Jena University Hospital, 07740 Jena (Germany); Chen, Yuan, E-mail: Yuan.Chen@med.uni-jena.de [Center for Molecular Biomedicine, Institute of Pathology, Jena University Hospital, 07740 Jena (Germany); Franz, Marcus, E-mail: Marcus.Franz@med.uni-jena.de [Clinic of Internal Medicine I, Jena University Hospital, 07740 Jena (Germany); Liebmann, Claus, E-mail: Claus.Liebmann@uni-jena.de [Institute of Biochemistry and Biophysics, Friedrich Schiller University Jena, 07740 Jena (Germany)

    2014-04-01

    Crosstalk between carcinoma associated fibroblasts (CAFs) and oral squamous cell carcinoma (OSCC) cells is suggested to mediate phenotype transition of cancer cells as a prerequisite for tumour progression, to predict patients’ outcome, and to influence the efficacy of EGFR inhibitor therapies. Here we investigate the influence of activated fibroblasts as a model for CAFs on phenotype and EGFR signalling in OSCC cells in vitro. For this, immortalised hTERT-BJ1 fibroblasts were activated with TGFβ1 and PDGFAB to generate a myofibroblast or proliferative phenotype, respectively. Conditioned media (FCM{sub TGF}, FCM{sub PDGF}) were used to stimulate PE/CA-PJ15 OSCC cells. Results were compared to the effect of conditioned media of non-stimulated fibroblasts (FCM{sub B}). FCM{sub TGF} stimulation leads to an up-regulation of vimentin in the OSCC cells and an enhancement of invasive behaviour, indicating EMT-like effects. Similarly, FCM{sub TGF}≫FCM{sub PDGF} induced up-regulation of EGFR, but not of ErbB2/ErbB3. In addition, we detected an increase in basal activities of ERK, PI3K/Akt and Stat3 (FCM{sub TGF}>FCM{sub PDGF}) accompanied by protein interaction of vimentin with pERK. These effects are correlated with an increased proliferation. In summary, our results suggest that the activated myofibroblast phenotype provides soluble factors which are able to induce EMT-like phenomena and to increase EGFR signalling as well as cell proliferation in OSCC cells. Our results indicate a possible influence of activated myofibroblasts on EGFR-inhibitor therapy. Therefore, CAFs may serve as promising novel targets for combined therapy strategies. - Highlights: • A cell culture model for cancer associated fibroblasts is described. • The mutual interaction with OSCC cells leads to up-regulation of EGFR in tumour cells. • mCAF induces EGFR downstream signalling with increased proliferation in OSCC. • Erk activation is associated with protein interaction with vimentin

  5. Interval Algebraic Bistructures

    CERN Document Server

    Kandasamy, W B Vasantha

    2011-01-01

    This book has four chapters. In the first chapter interval bistructures (biinterval structures) such as interval bisemigroup, interval bigroupoid, interval bigroup and interval biloops are introduced. Throughout this book we work only with the intervals of the form [0, a] where a \\in Zn or Z+ \\cup {0} or R+ \\cup {0} or Q+ \\cup {0} unless otherwise specified. Also interval bistructures of the form interval loop-group, interval groupgroupoid so on are introduced and studied. In chapter two n-interval structures are introduced. n-interval groupoids, n-interval semigroups, n-interval loops and so on are introduced and analysed. Using these notions n-interval mixed algebraic structure are defined and described. Some probable applications are discussed. Only in due course of time several applications would be evolved by researchers as per their need. The final chapter suggests around 295 problems of which some are simple exercises, some are difficult and some of them are research problems.

  6. Traffic Flow Theory

    OpenAIRE

    Maerivoet, Sven; De Moor, Bart

    2005-01-01

    The scientific field of traffic engineering encompasses a rich set of mathematical techniques, as well as researchers with entirely different backgrounds. This paper provides an overview of what is currently the state-of-the-art with respect to traffic flow theory. Starting with a brief history, we introduce the microscopic and macroscopic characteristics of vehicular traffic flows. Moving on, we review some performance indicators that allow us to assess the quality of traffic operations. A f...

  7. Optimizing Traffic Flow

    OpenAIRE

    Huberman, Bernardo A.; Helbing, Dirk

    1998-01-01

    We present an economics-based method for deciding the optimal rates at which vehicles are allowed to enter a highway. The method exploits the naturally occuring fluctuations of traffic flow and is flexible enough to adapt in real time to the transient flow characteristics of road traffic. Simulations based on realistic parameter values show that this strategy is feasible for naturally occuring traffic, and that even far from optimality, injection policies can improve traffic flow. Our results...

  8. Traffic-flow simulation

    OpenAIRE

    OMAHEN, ANDRAŽ

    2015-01-01

    This diploma thesis presents the behavior of program, which uses the traffic light enhanced transport network to simulate the traffic flow of vehicles that behave according to the IDM model. We upgraded the program to allow, for the given network, to optimize the traffic flow. Because of the overwhelming problem of road closures or their rearrangement, we added a graphical user interface with which a user can create or modify the road network to observe changes in traffic. The objective of...

  9. Traffic at risk in Mediterranean

    International Nuclear Information System (INIS)

    The Mediterranean Sea represents only about 0.7% of the planet's total water surface area, yet it is host to as much as one-quarter of the world's total maritime oil traffic. Statistics indicate that from 47 to 77,000 tonnes of crude oil are now being released annually into the Sea through accidental spills; and over the last decade, its tourism dependent coastlines have been fouled by the highest levels of tar contamination in the world. Oil carrier traffic, routed within the Sea's already overcrowded shipping lanes, is intense and this traffic is expected to increase, as a result of rises in world energy demand, to levels of from 7 to 8 million barrels a day. It has been estimated that, at the end of 1992, 90% of all large tankers operating in this area, will have reached a service life of 15-16 years which is very close to the average recommended life cycle limit of 15-20 years. Only 20% of the world's 3,000 tankers are currently equipped with double bottomed hulls. This paper uses these and other facts and figures to argue that the risks of future severe oil tanker accidents in the Mediterranean Sea are high, and that these must be countered with the development of a new set of stricter marine traffic safety regulations at the Italian, national, as well as, European level

  10. Traffic Flow Estimates.

    Science.gov (United States)

    Hart, Vincent G.

    1981-01-01

    Two examples are given of ways traffic engineers estimate traffic flow. The first, Floating Car Method, involves some basic ideas and the notion of relative velocity. The second, Maximum Traffic Flow, is viewed to involve simple applications of calculus. The material provides insight into specialized applications of mathematics. (MP)

  11. Controlling Disorder in Traffic Flow by Perturbation

    Institute of Scientific and Technical Information of China (English)

    LI Ke-Ping; GAO Zi-You; CHEN Tian-Lun

    2004-01-01

    We propose a new technique for controlling disorder in traffic system. A kind of control signal which can be considered as a perturbation has been designated at a given site (perturbation point) of the single-lane highway. When a vehicle passes the perturbation point at a time, the velocity of the vehicle will be changed at the next time by the perturbation. This technique is tested for the deterministic NaSch traffic model. The simulation results indicate that the traffic system can be transited from the disorder states to the order states, such as fixed-point, periodic motion, etc.

  12. Antipyrene clearance in Indian villagers.

    OpenAIRE

    Desai, N K; Sheth, U K; Mucklow, J C; Fraser, H S; Bulpitt, C J; Jones, S.W.; Dollery, C. T.

    1980-01-01

    1 Antipyrine clearance has been measured using saliva samples in 50 Maharashtrans from a village to the north of Bombay. 2 All subjects were very lean and were also anaemic probably as a result of hookworm infestation. 3 Antipyrine clearance was 36% faster than in White Londoners studied previously and more than twice as fast as in Asian immigrants living in London. 4 Clearance was 25% faster in men than in women but volume of distribution was also greater in men and mean half-lives did not d...

  13. Intelligent traffic control system using PLC

    Science.gov (United States)

    Barz, C.; Todea, C.; Latinovic, T.; Preradovic, D. M.; Deaconu, S.; Berdie, A.

    2016-08-01

    The paper presents the traffic control system controlled through a PLC which takes the signals from different sensors on roads. The global system developed ensures the coordination of four intersections, setting a path that respects coordination type green light, the integration of additional sensors, the implementation of probes radar to inform traffic participants about recommended speed for accessing the green state located in the intersection that will follow to cross.

  14. Video Traffic Prediction Using Neural Networks

    OpenAIRE

    Miloš Oravec; Miroslav Petráš; Filip Pilka

    2008-01-01

    In this paper, we consider video stream prediction for application in services likevideo-on-demand, videoconferencing, video broadcasting, etc. The aim is to predict thevideo stream for an efficient bandwidth allocation of the video signal. Efficient predictionof traffic generated by multimedia sources is an important part of traffic and congestioncontrol procedures at the network edges. As a tool for the prediction, we use neuralnetworks – multilayer perceptron (MLP), radial basis function n...

  15. Decision Assessment of Clearance Level on Radioactive Waste Management

    International Nuclear Information System (INIS)

    Radioactive waste on the safe level activity containing very small radioactive material gives small radiology influence to the human, it is not necessary to control by regulatory body. The radioactive waste on the safe level activity is safe to release as the common waste. For exemption of the control, it is required the safe activity level limits in which the value of clearance level is fulfilled by regulatory body, however until now it is not decided yet. The exemption decision is obtained if its activity is lower than or same with clearance level based on the annual effective dose receiving by public on the value is lower than or same with 0,01 mSv. The exposure pathways of radioactive waste to the human have important role for determination of clearance level. The decision assessment of clearance level on the radioactive waste management has been done by analysis of radioactive exposure pathways to the human for activities of the disposal and the recycle of solid wastes, also the release of liquid and gas effluent. For solid waste disposal, the exposure pathway was evaluated since the transportation of packed waste from the treatment facility to the disposal facility and during its operation. Exposure pathways for solid waste recycle consist of the pathways for handling and transportation of cleared material to the recycling facility, the fabrication and the utilization of its product. Exposure pathways for liquid and gas releases occur since its releases to the environment up to the human (public) by specific traffic lane. (author)

  16. Neurobehavioral performance in adolescents is inversely associated with traffic exposure.

    Science.gov (United States)

    Kicinski, Michal; Vermeir, Griet; Van Larebeke, Nicolas; Den Hond, Elly; Schoeters, Greet; Bruckers, Liesbeth; Sioen, Isabelle; Bijnens, Esmée; Roels, Harry A; Baeyens, Willy; Viaene, Mineke K; Nawrot, Tim S

    2015-02-01

    On the basis of animal research and epidemiological studies in children and elderly there is a growing concern that traffic exposure may affect the brain. The aim of our study was to investigate the association between traffic exposure and neurobehavioral performance in adolescents. We examined 606 adolescents. To model the exposure, we constructed a traffic exposure factor based on a biomarker of benzene (urinary trans,trans-muconic acid) and the amount of contact with traffic preceding the neurobehavioral examination (using distance-weighted traffic density and time spent in traffic). We used a Bayesian structural equation model to investigate the association between traffic exposure and three neurobehavioral domains: sustained attention, short-term memory, and manual motor speed. A one standard deviation increase in traffic exposure was associated with a 0.26 standard deviation decrease in sustained attention (95% credible interval: -0.02 to -0.51), adjusting for gender, age, smoking, passive smoking, level of education of the mother, socioeconomic status, time of the day, and day of the week. The associations between traffic exposure and the other neurobehavioral domains studied had the same direction but did not reach the level of statistical significance. The results remained consistent in the sensitivity analysis excluding smokers and passive smokers. The inverse association between sustained attention and traffic exposure was independent of the blood lead level. Our study in adolescents supports the recent findings in children and elderly suggesting that traffic exposure adversely affects the neurobehavioral function. PMID:25461422

  17. Concept of Operations for Interval Management Arrivals and Approach

    Science.gov (United States)

    Hicok, Daniel S.; Barmore, Bryan E.

    2016-01-01

    This paper presents the concept of operations for interval management operations to be deployed in the US National Airspace System (NAS) by the Federal Aviation Administration (FAA) after 2020. The use of interval management operations is described that begin in en route airspace and continue to a termination point inside the arrival terminal area, in a terminal environment that includes other arrival management tools such as arrival metering, Ground-based Interval Management - Spacing (GIM-S), and Terminal Sequencing and Spacing (TSAS). The roles of Air Traffic Controllers and Flight Crews and the ground automation tools that are used by Air Traffic Controllers to enable the primary operation and variations are described.

  18. An efficient method to detect periodic behavior in botnet traffic by analyzing control plane traffic

    Science.gov (United States)

    AsSadhan, Basil; Moura, José M.F.

    2013-01-01

    Botnets are large networks of bots (compromised machines) that are under the control of a small number of bot masters. They pose a significant threat to Internet’s communications and applications. A botnet relies on command and control (C2) communications channels traffic between its members for its attack execution. C2 traffic occurs prior to any attack; hence, the detection of botnet’s C2 traffic enables the detection of members of the botnet before any real harm happens. We analyze C2 traffic and find that it exhibits a periodic behavior. This is due to the pre-programmed behavior of bots that check for updates to download them every T seconds. We exploit this periodic behavior to detect C2 traffic. The detection involves evaluating the periodogram of the monitored traffic. Then applying Walker’s large sample test to the periodogram’s maximum ordinate in order to determine if it is due to a periodic component or not. If the periodogram of the monitored traffic contains a periodic component, then it is highly likely that it is due to a bot’s C2 traffic. The test looks only at aggregate control plane traffic behavior, which makes it more scalable than techniques that involve deep packet inspection (DPI) or tracking the communication flows of different hosts. We apply the test to two types of botnet, tinyP2P and IRC that are generated by SLINGbot. We verify the periodic behavior of their C2 traffic and compare it to the results we get on real traffic that is obtained from a secured enterprise network. We further study the characteristics of the test in the presence of injected HTTP background traffic and the effect of the duty cycle on the periodic behavior. PMID:25685512

  19. Interference Cancellation Using Replica Signal for HTRCI-MIMO/OFDM in Time-Variant Large Delay Spread Longer Than Guard Interval

    Directory of Open Access Journals (Sweden)

    Yuta Ida

    2012-01-01

    Full Text Available Orthogonal frequency division multiplexing (OFDM and multiple-input multiple-output (MIMO are generally known as the effective techniques for high data rate services. In MIMO/OFDM systems, the channel estimation (CE is very important to obtain an accurate channel state information (CSI. However, since the orthogonal pilot-based CE requires the large number of pilot symbols, the total transmission rate is degraded. To mitigate this problem, a high time resolution carrier interferometry (HTRCI for MIMO/OFDM has been proposed. In wireless communication systems, if the maximum delay spread is longer than the guard interval (GI, the system performance is significantly degraded due to the intersymbol interference (ISI and intercarrier interference (ICI. However, the conventional HTRCI-MIMO/OFDM does not consider the case with the time-variant large delay spread longer than the GI. In this paper, we propose the ISI and ICI compensation methods for a HTRCI-MIMO/OFDM in the time-variant large delay spread longer than the GI.

  20. Modelling the Traffic System

    Directory of Open Access Journals (Sweden)

    Važan Pavel

    2014-12-01

    Full Text Available The paper presents the simulation study results of the traffic system in the city of Hlohovec. The authors describe the process of building the model in Witness 2013c simulator. The individual entities of simulation model are explained in details, as the Witness simulator is primarily suitable for manufacture or service simulation and not for traffic system simulation. The goal of this paper is to analyse the traffic system and to suggest the changes for improving the traffic in the city of Hlohovec. All proposed measures will bring about 20% improvement of traffic when compared to the current state.

  1. Lithium clearance in chronic nephropathy

    DEFF Research Database (Denmark)

    Kamper, A L; Holstein-Rathlou, N H; Leyssac, P P;

    1989-01-01

    1. Lithium clearance measurements were made in 72 patients with chronic nephropathy of different aetiology and moderate to severely reduced renal function. 2. Lithium clearance was strictly correlated with glomerular filtration rate, and there was no suggestion of distal tubular reabsorption of...... clearance data were independent of whether renal disease was of primarily glomerular or tubular origin and, further, were not influenced by long-term conventional antihypertensive treatment. 6. It is concluded that, even with a reduced kidney function, the data are compatible with the suggestion that...... lithium clearance may be a measure of the delivery of sodium and water from the renal proximal tubule. With this assumption it was found that adjustment of the sodium excretion in chronic nephropathy initially takes place in the distal parts of the nephron (loop of Henle, distal tubule and collecting duct...

  2. Measurement of nasal mucociliary clearance.

    OpenAIRE

    Corbo, G M; Foresi, A; Bonfitto, P; Mugnano, A; Agabiti, N.; Cole, P J

    1989-01-01

    The saccharin test was carried out in a randomly selected sample of schoolchildren (142 boys and 153 girls, age range 11-14 years) to determine the variability and reproducibility of the test and to assess whether it could be used as a screening test for nasal mucociliary clearance. Nasal mucociliary clearance times were analysed according to clinical history (asthma, rhinitis, asthma with rhinitis, and acute upper respiratory tract infections), laboratory findings (positive skin test respons...

  3. Inherited Disorders of Bilirubin Clearance

    OpenAIRE

    Memon, Naureen; Weinberger, Barry I; Hegyi, Thomas; Aleksunes, Lauren M

    2015-01-01

    Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to defective 1) unconjugated bilirubin uptake and intrahepatic storage, 2) conjugation of glucuronic acid to bilirubin (e.g. Gilbert syndrome, Crigler-Najjar syndrome, Lucey-Driscoll syndrome, breast milk jaundice), 3) bilirubin excretion into bile (Dubin-Johnson syndrome), or 4) conjugated bilirubin re-uptake (Rotor syndrom...

  4. Method of mucociliary clearance assessment

    Science.gov (United States)

    Danilova, Tatiana V.; Manturov, Alexey O.; Ermakov, Igor Y.; Mareev, Gleb O.; Mareev, Oleg V.

    2016-04-01

    The article is devoted to the research capabilities of mucociliary clearance in the nasal cavity and paranasal sinuses using modern techniques of digital video recording and processing. We describe the setup and software for this method and the results of our research. Using microscope and digital camera we can provide a good method to study mucociliary clearance and by usage of special software we able to measure some characteristic of nasal mucosae and its main function.

  5. Optimization of congested traffic flow in systems with a localized periodic inhomogeneity

    OpenAIRE

    Tomer, Elad; Safonov, Leonid; Madar, Nilly; Havlin, Shlomo

    2001-01-01

    We study traffic flow on roads with a localized periodic inhomogeneity such as traffic signals, using a stochastic car-following model. We find that in cases of congestion, traffic flow can be optimized by controlling the inhomogeneity's frequency. By studying the wavelength dependence of the flux in stop-and-go traffic states, and exploring their stability, we are able to explain the optimization process. A general conclusion drawn from this study is, that the fundamental diagram of traffic ...

  6. DETECCIÓN Y RECONOCIMIENTO DE SEÑALES DE TRÁNSITO UTILIZANDO MATCHING DE CHAMFER DETECTION AND RECOGNITION OF TRAFFIC SIGNALS USING MATCHING OF CHAMFER

    Directory of Open Access Journals (Sweden)

    Cristián Arriagada García

    2007-08-01

    available details at first sight etc, in our case a prototype is presented which allows the opportunity to help a car driver to pay attention to the traffic signs on the road, attempting to assist the driver, and at the same time to avoid traffic infractions and accidents. The prototype developed with computer vision techniques, allows the detection and recognition of signposts that are on the road and to inform its nature to the driver through an audible sign or a visual projection. The research was mainly centered on the phases of initial detection; with the objective of taking into account a quick heuristic, taking advantage of the segmentation by color, with their characteristics of invariability of system HSV (Brightness, Saturation, Value [10], and/or initial detection by borders, making use of the improved algorithm of Chamfer [1], finally to detect and recognize the symbols of the sign, using transformation of distance techniques and hierarchical matching of Chamfer[1], conditioned to this kind of application. The prototype in the phase of proof was implemented in Matlab, with the initial purpose of proving the effectiveness of the methods that were used. Once they are proved an OpenCV was used to verify its functioning in real time.

  7. A delayed flow intersection model for dynamic traffic assignment

    OpenAIRE

    DURLIN, T; HENN, V

    2005-01-01

    Day-to-Day and Within-Day dynamics are classically observed in dynamic traffic assignment, but smaller ones due to traffic lights phases also occur. These micro variations induce flow fluctuations defined at a cycle time scale. Their precise knowledge is irrelevant in a dynamic traffic assignment context. We propose to integrate these micro dynamics into a new intersection model without stages in which their average effects must be taken into account, especially delay and flow restriction ge...

  8. Transition from Disorder to Order in Traffic Flow

    Institute of Scientific and Technical Information of China (English)

    LI Ke-Ping; GAO Zi-You

    2004-01-01

    We propose a new technique to investigate the dynamical transitions among the traffic phases. A type of the control signals has been designated at a given site (signal point) of the single-lane highway. Under the effect of the control signal, the velocity of the vehicle that passes the signal point will be changed periodically. Our method is tested for the deterministic NaSch traffic model. The simulation results demonstrate that the disorder states in the deterministic NaSch traffic model can be suppressed, and the different types of periodic states would occur.

  9. A novel solution for car traffic control based on radiometric microwave devices

    Science.gov (United States)

    Soldovieri, Francesco; Denisov, Alexander; Speziale, Victor

    2014-05-01

    The significant problem of traffic in big cities, connected with huge and building up quantity of automobile cars, demands for novel strategies, based on nonconventional solutions, in order to improve system traffic control, especially at crossroads. As well known, the usual solution is based on the time relay, which requires the installation of a fixed traffic interval (signal light switching) at a crossroad; this solution is low cost, but does not account for the actual traffic conditions. Therefore, in the recent years, attention is towards to new designs, where the monitoring of the and control of traffic is carried out by using various methods including, optical, the infrared, magnetic, radar tracking, acoustical ones. In this work, we discuss the deployment of high sensitivity radiometric systems and radiometers(sensor) in the microwave range [1, 2]. In fact, the radiometer as "sensor" can provide an always updated information about the car traffic in any weather condition and in absence or low visibility conditions. In fact, the radiometric sensor detects the cars thanks to the different behavior of the car roofs which reflect the cold sky whereas the road asphalt is visible as warm object (at around outside temperature). [1] A. G. Denisov, V. P. Gorishnyak, S. E. Kuzmin et al., "Some experiments concerning resolution of 32 sensors passive 8mm wave imaging system," in Proceedings of the International Symposium on Space Terahertz Technology (ISSTT '09), Charlottesville, Va, USA, April 2009. [2] F. Soldovieri, A. Natale, V. Gorishnyak, A. Pavluchenko, A. Denisov, and L. Chen, "Radiometric Imaging for Monitoring and Surveillance Issues," International Journal of Antennas and Propagation, vol. 2013, Article ID 272561, 8 pages, 2013. doi:10.1155/2013/272561.

  10. Implications of traffic characteristics on interdomain traffic engineering

    OpenAIRE

    Uhlig, Steve

    2004-01-01

    This thesis discusses the implications of the traffic characteristics on interdomain traffic engineering with BGP. We first provide an overview of the interdomain traffic control problem. Then, we present results concerning the characteristics of the interdomain traffic, based on the analysis of real traffic traces gathered from non-transit ASes. We discuss the implications of the topological properties of the traffic on interdomain traffic engineering. Based on this knowledge of the...

  11. Occupant traffic estimation through structural vibration sensing

    Science.gov (United States)

    Pan, Shijia; Mirshekari, Mostafa; Zhang, Pei; Noh, Hae Young

    2016-04-01

    The number of people passing through different indoor areas is useful in various smart structure applications, including occupancy-based building energy/space management, marketing research, security, etc. Existing approaches to estimate occupant traffic include vision-, sound-, and radio-based (mobile) sensing methods, which have placement limitations (e.g., requirement of line-of-sight, quiet environment, carrying a device all the time). Such limitations make these direct sensing approaches difficult to deploy and maintain. An indirect approach using geophones to measure floor vibration induced by footsteps can be utilized. However, the main challenge lies in distinguishing multiple simultaneous walkers by developing features that can effectively represent the number of mixed signals and characterize the selected features under different traffic conditions. This paper presents a method to monitor multiple persons. Once the vibration signals are obtained, features are extracted to describe the overlapping vibration signals induced by multiple footsteps, which are used for occupancy traffic estimation. In particular, we focus on analysis of the efficiency and limitations of the four selected key features when used for estimating various traffic conditions. We characterize these features with signals collected from controlled impulse load tests as well as from multiple people walking through a real-world sensing area. In our experiments, the system achieves the mean estimation error of +/-0.2 people for different occupant traffic conditions (from one to four) using k-nearest neighbor classifier.

  12. RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS

    OpenAIRE

    Z. IQBAL, I. JAVED, B. ASLAM, F. MUHAMMAD AND I. U. JAN

    2007-01-01

    The renal clearance and urinary excretion of ciprofloxacin were investigated in eight healthy female goats. In each animal, ciprofloxacin was administered intramuscularly at the rate of 5 mg/kg body weight. Following drug administration, blood and urine samples were collected at different time intervals and analyzed for ciprofloxacin and creatinine. High performance liquid chromatography (HPLC) was used to determine the drug concentration in the plasma and urine. The value of diuresis after s...

  13. A Sarsa(λ-Based Control Model for Real-Time Traffic Light Coordination

    Directory of Open Access Journals (Sweden)

    Xiaoke Zhou

    2014-01-01

    Full Text Available Traffic problems often occur due to the traffic demands by the outnumbered vehicles on road. Maximizing traffic flow and minimizing the average waiting time are the goals of intelligent traffic control. Each junction wants to get larger traffic flow. During the course, junctions form a policy of coordination as well as constraints for adjacent junctions to maximize their own interests. A good traffic signal timing policy is helpful to solve the problem. However, as there are so many factors that can affect the traffic control model, it is difficult to find the optimal solution. The disability of traffic light controllers to learn from past experiences caused them to be unable to adaptively fit dynamic changes of traffic flow. Considering dynamic characteristics of the actual traffic environment, reinforcement learning algorithm based traffic control approach can be applied to get optimal scheduling policy. The proposed Sarsa(λ-based real-time traffic control optimization model can maintain the traffic signal timing policy more effectively. The Sarsa(λ-based model gains traffic cost of the vehicle, which considers delay time, the number of waiting vehicles, and the integrated saturation from its experiences to learn and determine the optimal actions. The experiment results show an inspiring improvement in traffic control, indicating the proposed model is capable of facilitating real-time dynamic traffic control.

  14. A Sarsa(λ)-based control model for real-time traffic light coordination.

    Science.gov (United States)

    Zhou, Xiaoke; Zhu, Fei; Liu, Quan; Fu, Yuchen; Huang, Wei

    2014-01-01

    Traffic problems often occur due to the traffic demands by the outnumbered vehicles on road. Maximizing traffic flow and minimizing the average waiting time are the goals of intelligent traffic control. Each junction wants to get larger traffic flow. During the course, junctions form a policy of coordination as well as constraints for adjacent junctions to maximize their own interests. A good traffic signal timing policy is helpful to solve the problem. However, as there are so many factors that can affect the traffic control model, it is difficult to find the optimal solution. The disability of traffic light controllers to learn from past experiences caused them to be unable to adaptively fit dynamic changes of traffic flow. Considering dynamic characteristics of the actual traffic environment, reinforcement learning algorithm based traffic control approach can be applied to get optimal scheduling policy. The proposed Sarsa(λ)-based real-time traffic control optimization model can maintain the traffic signal timing policy more effectively. The Sarsa(λ)-based model gains traffic cost of the vehicle, which considers delay time, the number of waiting vehicles, and the integrated saturation from its experiences to learn and determine the optimal actions. The experiment results show an inspiring improvement in traffic control, indicating the proposed model is capable of facilitating real-time dynamic traffic control. PMID:24592183

  15. Pinostrobin from Boesenbergia pandurata is an inhibitor of Ca2+-signal-mediated cell-cycle regulation in the yeast Saccharomyces cerevisiae.

    Science.gov (United States)

    Wangkangwan, Wachirasak; Boonkerd, Saipin; Chavasiri, Warinthorn; Sukapirom, Kasama; Pattanapanyasat, Kovit; Kongkathip, Ngampong; Miyakawa, Tokichi; Yompakdee, Chulee

    2009-07-01

    Upon searching plant extracts for inhibitors of the Ca(2+) signaling pathway using the zds1Delta-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca(2+) signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae. PMID:19584530

  16. Remotely Accessed Vehicle Traffic Management System

    Science.gov (United States)

    Al-Alawi, Raida

    2010-06-01

    The ever increasing number of vehicles in most metropolitan cities around the world and the limitation in altering the transportation infrastructure, led to serious traffic congestion and an increase in the travelling time. In this work we exploit the emergence of novel technologies such as the internet, to design an intelligent Traffic Management System (TMS) that can remotely monitor and control a network of traffic light controllers located at different sites. The system is based on utilizing Embedded Web Servers (EWS) technology to design a web-based TMS. The EWS located at each intersection uses IP technology for communicating remotely with a Central Traffic Management Unit (CTMU) located at the traffic department authority. Friendly GUI software installed at the CTMU will be able to monitor the sequence of operation of the traffic lights and the presence of traffic at each intersection as well as remotely controlling the operation of the signals. The system has been validated by constructing a prototype that resembles the real application.

  17. Energy consumption in rail traffic

    International Nuclear Information System (INIS)

    This report for the Swiss Federal Office of Energy (SFOE) presents the first results of a short study made on the energy consumption of the Swiss rail-bound systems for the transport of persons and goods. In this initial short study, data collected on the electricity and fossil fuel consumption of the Swiss Federal Railways and further railway companies in Switzerland is presented. The consumption is split into various categories such as person and goods traffic, internal traffic, building-infrastructure (stations, workshops, tunnels etc.) and equipment (signals, point-heaters, lighting, safety equipment). Data is presented in tables and in graphical form in relation to person-kilometres and tonne-kilometres. The development of consumption over a period of years is discussed and comparisons are made with figures for the German rail system

  18. Implementation of Neural Network with a variant of Turing Machine for Traffic Flow Control

    OpenAIRE

    Rashmi Sehrawat; Honey Malviya; Vanditaa Kaul

    2013-01-01

    The conventional method of operation of a typical traffic light is to distribute the time equally for all the directions.This method causes congestion when throughput of the signal increases and is alsoineffective in managing traffic flow. In this paper, we have proposed a new model for managing traffic intelligently.The model is based on Turing machine with the application of neural network. The modelconsiders current traffic status of its own signal along with the status of its adjacent sig...

  19. Glomerular filtration in kidney recipients measured by plasma clearance of 169Yb-DTPA

    International Nuclear Information System (INIS)

    Values of 169Yb-DTPA clearance (CDTPA) calculated after a single injection were compared in 26 recipients of kidneys with renal clearance of inulin (Cin), polyfructosan S (Cpf) and creatinine (Ccr). In 21 patients the examinations were made simultaneously, in 5 patients CDTPA was measured within a short interval after the examination of renal clearance. The mean CDTPA values did not significantly differ from Ccr but were significantly higher (pin and Cpf (by 33% on average). Investigation of changes in CDTPA as compared with Cin and Cpf showed no significant difference in glomerular filtration (GF). This was measured using inulin and polyfructosan. The results showed that the differing molecular weight of inulin and polyfructosan S had no detectable effect on the GF of kidney recipients. The plasma clearance of 169Yb-DTPA similarly to Ccr overestimates the GF measured by inulin and polyfructosan clearance. (author)

  20. Costs of traffic injuries

    DEFF Research Database (Denmark)

    Kruse, Marie

    2015-01-01

    OBJECTIVE: The aim of this study was to analyse the socioeconomic costs of traffic injuries in Denmark, notably the healthcare costs and the productivity costs related to traffic injuries, in a bottom-up, register-based perspective. METHOD: Traffic injury victims were identified using national...... emergency room data and police records. Victims were matched with five controls per case by means of propensity score, nearest-neighbour matching. In the cohort, consisting of the 52 526 individuals that experienced a traffic injury in 2000 and 262 630 matched controls, attributable healthcare costs were...... assessed using Danish national healthcare registers. Productivity costs were computed using duration analysis (Cox regression models). In a subanalysis, cost per severe traffic injury was computed for the 12 995 individuals that experienced a severe injury. RESULTS: The socioeconomic cost of a traffic...

  1. Trajectory Based Traffic Analysis

    DEFF Research Database (Denmark)

    Krogh, Benjamin Bjerre; Andersen, Ove; Lewis-Kelham, Edwin;

    2013-01-01

    We present the INTRA system for interactive path-based traffic analysis. The analyses are developed in collaboration with traffic researchers and provide novel insights into conditions such as congestion, travel-time, choice of route, and traffic-flow. INTRA supports interactive point-and-click a......We present the INTRA system for interactive path-based traffic analysis. The analyses are developed in collaboration with traffic researchers and provide novel insights into conditions such as congestion, travel-time, choice of route, and traffic-flow. INTRA supports interactive point......-and-click analysis, due to a novel and efficient indexing structure. With the web-site daisy.aau.dk/its/spqdemo/we will demonstrate several analyses, using a very large real-world data set consisting of 1.9 billion GPS records (1.5 million trajectories) recorded from more than 13000 vehicles, and touching most of...

  2. Identifying file-sharing P2P traffic based on traffic characteristics

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    This article focuses on identifying file-sharing peer-to-peer (P2P) (such as BitTorrent (BT)) traffic at the borders of a stub network. By analyzing protocols and traffic of applications, it is found that file-sharing P2P traffic of a single user differs greatly from traditional and other P2P (such as QQ) applications' traffic in the distribution of involved remote hosts and remote ports. Therefore, a method based on discreteness of remote hosts (RHD) and discreteness of remote ports (RPD) is proposed to identify BT-like traffic. This method only relies on flow information of each user host in a stub network, and no packet payload needs to be monitored. At intervals, instant RHD for concurrent transmission control protocol and user datagram protocol flows for each host are calculated respectively through grouping flows by the stub network that the remote host of each flow belongs to. On given conditions, instant RPD are calculated through grouping flows by the remote port to amend instant RHD. Whether a host has been using a BT-like application or not can be deduced from instant RHD or average RHD for a period of time. The proposed method based on traffic characteristics is more suitable for identifying protean file-sharing P2P traffic than content-based methods. Experimental results show that this method is effective with high accuracy.

  3. PR Interval Behavior During Exercise Stress Test

    OpenAIRE

    Lee, Jae Ung; Kim, Kyung Soo; Kim, Jeong Hyun; Lim, Heon Kil; Lee, Bang Hun; Lee, Chung Kyun

    1995-01-01

    Objectives: The PR interval on the electrocardiogram represents conduction time from the onset of atrial activation through His-Purkinje conduction system during a normal cardiac cycle. While its behavior at rest and during exposure to various cardioactive drugs is well documented, there exist few reports which describe PR interval variations during exercise in normal control and patient groups. In the present study, We examined the behavior of the PR intervals during various stages of exerci...

  4. ADMA metabolism and clearance

    OpenAIRE

    Teerlink, Tom

    2005-01-01

    Abstract The plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is the resultant of many processes at cellular and organ levels. Post-translational methylation of arginine residues of proteins plays a crucial role in the regulation of their functions, which include processes such as transcription, translation and RNA splicing. Because protein methylation is irreversible, the methylation signal can be turned off only by prot...

  5. ADMA metabolism and clearance

    OpenAIRE

    Teerlink, Tom

    2005-01-01

    Abstract The plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is the resultant of many processes at cellular and organ levels. Post-translational methylation of arginine residues of pro teins plays a crucial role in the regulation of their functions, which include processes such as transcription, translation and RNA splicing. Because protein methylation is irreversible, the methylation signal can be turned off only by pro...

  6. Internet Traffic Engineering

    OpenAIRE

    Bonaventure, Olivier; Trimintzios, Panos; Pavlou, George; Quoitin, Bruno; Azcorra, Arturo; Bagnulo, Marcelo; Fegkas, Paris; García-Martínez, Alberto; Georgatsos, Panos; Georgiadis, Leonidas; Jacquenet, Christian; Swinnen, Louis; Tandel, Sebastien; Uhlig, Steve

    2004-01-01

    Traffic engineering encompasses a set of techniques that can be used to control the flow of traffic in data networks. We discuss several of those techniques that have been developed during the last few years. Some techniques are focused on pure IP networks while others have been designed with emerging technologies for scalable Quality of Service (QoS) such as Differentiated Services and MPLS in mind. We first discuss traffic engineering techniques inside a single domain. We show that by using...

  7. Distraction in traffic.

    OpenAIRE

    2013-01-01

    Many drivers, as well as cyclists and pedestrians, are occupied with all kinds of activities that can distract their attention from traffic, like listening to music, conducting a conversation on their mobile phone, or texting. Distraction has negative effects on traffic behaviour. Most studies estimate that distraction plays a role in the occurrence of about 5-25% of the car crashes. Considering the increasing diffusion of electronic devices in traffic, portable media devices as well as advan...

  8. Traffic Congestion and Accidents

    OpenAIRE

    Schrage, Andrea

    2006-01-01

    Obstructions caused by accidents can trigger or exacerbate traffic congestion. This paper derives the efficient traffic pattern for a rush hour with congestion and accidents and the corresponding road toll. Compared to the model without accidents, where the toll equals external costs imposed on drivers using the road at the same time, a new insight arises: An optimal toll also internalizes the expected increase in future congestion costs. Since accidents affect more drivers if traffic volumes...

  9. Traffic Signs Inventory System

    Directory of Open Access Journals (Sweden)

    J. Ružbarský

    2013-06-01

    Full Text Available The paper is focused on practical application of Cambridge Correlator. The goal is to propose a traffic signs inventory system by using excellent characteristics of correlator in the rapid optical correlation. The proposal of this inventory system includes obtaining of traffic signs to create the database either collecting the GPS coordinates. It is necessary to know the traffic signs position and also to document the entire surface route for later evaluation in offline mode.

  10. Traffic Light Options

    OpenAIRE

    Løchte, Peter

    2006-01-01

    This paper introduces, prices, and analyzes traffic light options. The traffic light option is an innovative structured OTC derivative developed independently by several London-based investment banks to suit the needs of Danish life and pension (L&P) companies, which must comply with the traffic light solvency stress test system introduced by the Danish Financial Supervisory Authority (DFSA) in June 2001. This monitoring system requires L&P companies to submit regular reports documenting the ...

  11. Network Traffic Anomaly Detection

    OpenAIRE

    Huang, Hong; Al-Azzawi, Hussein; Brani, Hajar

    2014-01-01

    This paper presents a tutorial for network anomaly detection, focusing on non-signature-based approaches. Network traffic anomalies are unusual and significant changes in the traffic of a network. Networks play an important role in today's social and economic infrastructures. The security of the network becomes crucial, and network traffic anomaly detection constitutes an important part of network security. In this paper, we present three major approaches to non-signature-based network detect...

  12. Electroencephalographic signals synchronize with behaviors and are sexually dimorphic during the light-dark cycle in reproductive frogs.

    Science.gov (United States)

    Yang, Ping; Fang, Guangzhan; Xue, Fei; Cui, Jianguo; Brauth, Steven E; Tang, Yezhong

    2014-02-01

    Male frogs behave differently from females during the breeding season, particularly with respect to courtship displays and in response to mating signals. In search of physiological correlates of these differences, the present study measured changes in baseline electroencephalogram (EEG) power output within four frequency bands in the telencephalon and mesencephalon, together with changes in locomotor activity as a function of the light-dark cycle in male and female Emei music frogs (Babina daunchina) at the reproductive stage. Previous studies have shown that male vocal activity varies both seasonally and daily in this species and that females use male advertisement calls to locate and select mates. The present results show that both EEG and locomotor activity exhibit highly correlated circadian patterns with peaks around light onset and offset. Importantly, during the reproductive stage, statistically significant sex differences in EEG output across brain regions during the light and dark phases were found indicating that sexual dimorphism exists for EEG activity which may underlie sexually specific information processing and behavioral activities. PMID:24337372

  13. Traffic Flow Management System

    Data.gov (United States)

    Department of Transportation — TFMS is a set NAS operational tools that predict demand, identify constraints, and facilitates collaboration among NAS users to support efficient traffic flow while...

  14. Subjective safety in traffic.

    OpenAIRE

    2012-01-01

    The term ‘subjective safety in traffic’ refers to people feeling unsafe in traffic or, more generally, to anxiety regarding being unsafe in traffic for oneself and/or others. Subjective safety in traffic can lead to road users limiting their mobility and social activities, which is one of the reasons it warrants policy-related attention. However, research has shown that, at most, there is a weak link between objective and subjective safety in traffic. There are even indications that some subj...

  15. Lithium clearance in chronic nephropathy

    DEFF Research Database (Denmark)

    Kamper, A L; Holstein-Rathlou, N H; Leyssac, P P;

    1989-01-01

    1. Lithium clearance measurements were made in 72 patients with chronic nephropathy of different aetiology and moderate to severely reduced renal function. 2. Lithium clearance was strictly correlated with glomerular filtration rate, and there was no suggestion of distal tubular reabsorption of...... lithium or influence of osmotic diuresis. 3. Fractional reabsorption of lithium was reduced in most patients with glomerular filtration rates below 25 ml/min. 4. Calculated fractional distal reabsorption of sodium was reduced in most patients with glomerular filtration rates below 50 ml/min. 5. Lithium...... lithium clearance may be a measure of the delivery of sodium and water from the renal proximal tubule. With this assumption it was found that adjustment of the sodium excretion in chronic nephropathy initially takes place in the distal parts of the nephron (loop of Henle, distal tubule and collecting duct...

  16. Lactate clearance in cardiorespiratory emergency

    Directory of Open Access Journals (Sweden)

    Serena Greco

    2007-08-01

    Full Text Available Early goal directed therapy has been found to improve prognosis in septic patients, if the therapeutic goal is achieved within the first six hours. The aim of our study is to demonstrate that in patients with acute cardiorespiratory failure, rapid (within 2 hours lactate clearance can help define patients’ prognosis. 67 consecutive patients, admitted to our 16-bed Emergency Medicine ward for acute cardiorespiratory failure (age 75,9 ± 9,8 (APACHE II score 19,0 ± 4,1, were included in the study. Blood lactate concentration was read at admission and after 2, 6 and 24 hours. We evaluated mortality at seven days and the use of orotracheal intubation (patients with negative outcome vs. discharge or transfer to a non-emergency ward with subsequent discharge (patients with negative outcome. Lactate concentration at admission was 4,6 ± 2,5 mmol/l; lactate clearance (% at 2 hours was 40,4 ± 32,1 in patients with a positive outcome and –8,3 ± 5,0 in patients with a negative outcome (p < 0,05. Lactate clearance at 2 hours < 25% is correlated to a negative outcome with an 84,2% sensitivity and a 79,2% specificity. The positive predictive value was 61,5% and the negative predictive value was 92,2%. Systematic lactate clearance monitoring can be used in cases of acute cardiorespiratory insufficiency to identify patients with a high risk of negative outcome. In our study, low clearance at two hours was associated with an increase in mortality and/or the need for orotracheal intubation. Conversely, a clearance at two hours of > 25% in most cases confirms the therapeutic strategy undertaken. Serial evaluation of blood lactate concentration may therefore be useful in guiding treatment strategies.

  17. Impacts of Traffic Noise and Traffic Volume on Birds of Roadside Habitats

    Directory of Open Access Journals (Sweden)

    Angela Schneider

    2009-06-01

    Full Text Available Roadside habitats are important for a range of taxa including plants, insects, mammals, and birds, particularly in developed countries in which large expanses of native vegetation have been cleared for agriculture or urban development. Although roadside vegetation may provide suitable habitat for many species, resident animals can be exposed to high levels of traffic noise, visual disturbance from passing vehicles, and the risk of collision with cars and trucks. Traffic noise can reduce the distance over which acoustic signals such as song can be detected, an effect known as acoustic interference or masking. Studies from the northern hemisphere show that the singing behavior of birds changes in the presence of traffic noise. We investigated the impact of traffic noise and traffic volume on two species of birds, the Grey Shrike-thrush (Colluricincla harmonica and the Grey Fantail (Rhipidura fuliginosa, at 58 roadside sites on the Mornington Peninsula, southeastern Australia. The lower singing Grey Shrike-thrush sang at a higher frequency in the presence of traffic noise, with a predicted increase in dominant frequency of 5.8 Hz/dB of traffic noise, and a total effect size of 209 Hz. In contrast, the higher singing Grey Fantail did not appear to change its song in traffic noise. The probability of detecting each species on a visit to a site declined substantially with increasing traffic noise and traffic volume, with several lines of evidence supporting a larger effect of traffic noise. Traffic noise could hamper detection of song by conspecifics, making it more difficult for birds to establish and maintain territories, attract mates and maintain pair bonds, and possibly leading to reduced breeding success in noisy roadside habitats. Closing key roads during the breeding season is a potential, but untested, management strategy to protect threatened bird species from traffic noise and collision with vehicles at the time of year when they are most

  18. Nuclear security. DOE actions to improve the personnel clearance program

    International Nuclear Information System (INIS)

    The status of the Department of Energy's (DOE) implementation of recommendations in our two reports on DOE's personnel security clearance program was determined. The recommendations were aimed at improving the timeliness, accuracy, and efficiency of personnel security clearance decisions. Specifically, the objective was to determine and report on steps DOE is taking to implement these recommendations. In summary, it was found that DOE has either initiated action or is studying ways to address all the recommendations, but none of the recommendations have been completely implemented. The effectiveness of the DOE actions will depend, in part, on the adequacy of its internal control system for overseeing and evaluating program operations. DOE's personnel security clearance program is intended to provide reasonable assurance that personnel with access to classified information and materials are trustworthy. The Department requests that the Office of Personnel Management or the Federal Bureau of Investigation collect personal data on each person who requires such access to do his or her job. Based on these background investigations, DOE officials authorize individuals whose personal histories indicate that they are trustworthy to have access to classified information, secured facilities, and controlled materials as needed to perform their jobs. DOE has five types of these authorizations or personnel security clearances and must update information on personnel holding each type at 5-year intervals to confirm their continuing reliability. The five types are based on the types of security interests to which the person needs access, e.g., persons needing nuclear weapons-related data must have a Q clearance, and persons with a top secret clearance can have access to national security data classified as top secret

  19. Inherited Disorders of Bilirubin Clearance

    Science.gov (United States)

    Memon, Naureen; Weinberger, Barry I; Hegyi, Thomas; Aleksunes, Lauren M

    2016-01-01

    Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to defective 1) unconjugated bilirubin uptake and intrahepatic storage, 2) conjugation of glucuronic acid to bilirubin (e.g. Gilbert syndrome, Crigler-Najjar syndrome, Lucey-Driscoll syndrome, breast milk jaundice), 3) bilirubin excretion into bile (Dubin-Johnson syndrome), or 4) conjugated bilirubin re-uptake (Rotor syndrome). In this review, the molecular mechanisms and clinical manifestations of these conditions are described, as well as current approaches to diagnosis and therapy. PMID:26595536

  20. Sulfadoxine-pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy

    DEFF Research Database (Denmark)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2002-01-01

    Following widespread chloroquine (CQ) resistance, sulfadoxine plus pyrimethamine (SP) is now the first line antimalarial drug in a number of African countries including Tanzania. Unlike CQ, SP has no antipyretic effects, a feature that might delay fever clearance, and by acting on late stage...... paracetamol (PCM) (n=38) in children with uncomplicated malaria. Over 72 h, there were eight (20.5%) treatment failures in the CQ group but none in the other groups. Although not significant (P > 0.1), irrespective of resistance CQ alone had a shorter median survival time to fever clearance than SP alone (54...... resistance, CQ alone had a median survival time to parasite clearance equal to that of SP alone (48 h). Parasite clearance by SP was rapid and at the end of 72 h, most (77.3%, 95% confidence interval: 69.6, 85.0) of the children on SP (as a group) had become aparasitaemic. The findings rule out concerns on...

  1. The Traffic Light Challenge

    Science.gov (United States)

    Roman, Harry T.

    2014-01-01

    Traffic lights are an important part of the transportation infrastructure, regulating traffic flow and maintaining safety when crossing busy streets. When they go awry or become nonfunctional, a great deal of havoc and danger can be present. During power outages, the street lights go out all over the affected area. It would be good to be able to…

  2. Distraction in traffic.

    NARCIS (Netherlands)

    2013-01-01

    Many drivers, as well as cyclists and pedestrians, are occupied with all kinds of activities that can distract their attention from traffic, like listening to music, conducting a conversation on their mobile phone, or texting. Distraction has negative effects on traffic behaviour. Most studies estim

  3. Road Traffic in China

    NARCIS (Netherlands)

    Jie, L.; Van Zuylen, H.J.

    2014-01-01

    Traffic is tightly related to the social and economic development in a country. In China the development of the economy has been very fast in the past 30 years and this is still continuing. The transport infrastructure shows a similar pattern, while traffic is also rapidly growing. In urban areas th

  4. Controlled Traffic Farming

    OpenAIRE

    Controlled Traffic Farming Europe

    2011-01-01

    Metadata only record Controlled Traffic Farming (CTF) is a farming method used to reduce soil compaction, decrease inputs, and improve soil structure when coupled with reduced-till or no-till practices. This practices utilizes permanent traffic/wheel zones to limit soil compaction to a specific area. This website provides practical information on CTF, case studies, workshops, and links to additional resources.

  5. Visualization of Traffic Accidents

    Science.gov (United States)

    Wang, Jie; Shen, Yuzhong; Khattak, Asad

    2010-01-01

    Traffic accidents have tremendous impact on society. Annually approximately 6.4 million vehicle accidents are reported by police in the US and nearly half of them result in catastrophic injuries. Visualizations of traffic accidents using geographic information systems (GIS) greatly facilitate handling and analysis of traffic accidents in many aspects. Environmental Systems Research Institute (ESRI), Inc. is the world leader in GIS research and development. ArcGIS, a software package developed by ESRI, has the capabilities to display events associated with a road network, such as accident locations, and pavement quality. But when event locations related to a road network are processed, the existing algorithm used by ArcGIS does not utilize all the information related to the routes of the road network and produces erroneous visualization results of event locations. This software bug causes serious problems for applications in which accurate location information is critical for emergency responses, such as traffic accidents. This paper aims to address this problem and proposes an improved method that utilizes all relevant information of traffic accidents, namely, route number, direction, and mile post, and extracts correct event locations for accurate traffic accident visualization and analysis. The proposed method generates a new shape file for traffic accidents and displays them on top of the existing road network in ArcGIS. Visualization of traffic accidents along Hampton Roads Bridge Tunnel is included to demonstrate the effectiveness of the proposed method.

  6. Traffic Light Options

    DEFF Research Database (Denmark)

    Jørgensen, Peter Løchte

    This paper introduces, prices, and analyzes traffic light options. The traffic light option is an innovative structured OTC derivative developed independently by several London-based investment banks to suit the needs of Danish life and pension (L&P) companies, which must comply with the traffic...... light solvency stress test system introduced by the Danish Financial Supervisory Authority (DFSA) in June 2001. This monitoring system requires L&P companies to submit regular reports documenting the sensitivity of the companies' base capital to certain pre-defined market shocks - the red and yellow...... light scenarios. These stress scenarios entail drops in interest rates as well as in stock prices, and traffic light options are thus designed to pay off and preserve sufficient capital when interest rates and stock prices fall simultaneously. Sweden's FSA implemented a traffic light system in January...

  7. Traffic Light Options

    DEFF Research Database (Denmark)

    Jørgensen, Peter Løchte

    2007-01-01

    This paper introduces, prices, and analyzes traffic light options. The traffic light option is an innovative structured OTC derivative developed independently by several London-based investment banks to suit the needs of Danish life and pension (L&P) companies, which must comply with the traffic...... light solvency stress test system introduced by the Danish Financial Supervisory Authority (DFSA) in June 2001. This monitoring system requires L&P companies to submit regular reports documenting the sensitivity of the companies' base capital to certain pre-defined market shocks - the red and yellow...... light scenarios. These stress scenarios entail drops in interest rates as well as in stock prices, and traffic light options are thus designed to pay off and preserve sufficient capital when interest rates and stock prices fall simultaneously. Sweden's FSA implemented a traffic light system in January...

  8. Synchronization of Traffic Light Systems for Maximum Efficiency along Jalan Bukit Gambier, Penang, Malaysia

    Directory of Open Access Journals (Sweden)

    Ahmad Rafidi M.A.

    2014-01-01

    Full Text Available The synchronization of traffic light systems is one of the best solutions in order to avoid problematic traffic jams. Traffic timing is a major concern when it comes to traffic management. One of the common causes of traffic jams is because of nonsynchronized traffic light systems. Once a light turns green, traffic begins to move, but by the time the moving traffic reaches the next light, the signal is still red. This will disrupt the continuity of the traffic flow, especially for large main roads. The smooth flow of traffic on main routes is important to clear dense traffic in a given time. This study examined the density of vehicles on Jalan Bukit Gambier and also the traffic timing was documented in order to plan out proper re-timing for traffic lights along the studied road. The outcomes of this study support the hypothesis that retiming traffic lights to create a synchronized traffic light system for main roads will greatly improve traffic flow.

  9. Multi-Layer Traffic Steering

    DEFF Research Database (Denmark)

    Fotiadis, Panagiotis; Polignano, Michele; Gimenez, Lucas Chavarria; Viering, Ingo; Sartori, Cinzia; Lobinger, Andreas; Pedersen, Klaus I.

    2013-01-01

    This paper investigates the potentials of traffic steering in the Radio Resource Control (RRC) Idle state by evaluating the Absolute Priorities (AP) framework in a multilayer Long Term Evolution (LTE) macrocell scenario. Frequency priorities are broadcast on the system information and RRC Idle...... signaling. The priority adjustment is based on both the Composite Available Capacity (CAC) and the radio conditions of the candidate layers. Compared to broadcast AP, the proposed scheme achieves better load balancing performance and improves network capacity, given that the User Equipment (UE) inactivity...

  10. Bayesian credible interval construction for Poisson statistics

    Institute of Scientific and Technical Information of China (English)

    ZHU Yong-Sheng

    2008-01-01

    The construction of the Bayesian credible (confidence) interval for a Poisson observable including both the signal and background with and without systematic uncertainties is presented.Introducing the conditional probability satisfying the requirement of the background not larger than the observed events to construct the Bayesian credible interval is also discussed.A Fortran routine,BPOCI,has been developed to implement the calculation.

  11. Abnormal traffic flow data detection based on wavelet analysis

    Directory of Open Access Journals (Sweden)

    Xiao Qian

    2016-01-01

    Full Text Available In view of the traffic flow data of non-stationary, the abnormal data detection is difficult.proposed basing on the wavelet analysis and least squares method of abnormal traffic flow data detection in this paper.First using wavelet analysis to make the traffic flow data of high frequency and low frequency component and separation, and then, combined with least square method to find abnormal points in the reconstructed signal data.Wavelet analysis and least square method, the simulation results show that using wavelet analysis of abnormal traffic flow data detection, effectively reduce the detection results of misjudgment rate and false negative rate.

  12. The cycle-dependence of Far-UV and Middle-UV solar emission: EMD analysis of SOLSTICE and Mg II signals

    Science.gov (United States)

    Berrilli, Francesco; Lovric, Mija; Federico, Tosone; Cagnazzo, Chiara; Del Moro, Dario; Pietropaolo, Ermanno

    2016-04-01

    The solar Far-UV and Middle-UV variability is extremely relevant for the stratospheric ozone concentration and dynamics. We investigate solar UV variability at decennial time scale using the data of SOLar-STellar Irradiance Comparison Experiment (SOLSTICE) on SORCE and Bremen Mg II composite signal. The Empirical Mode Decomposition (EMD) technique has been applied to Mg II and UV signals to separate intrinsic solar components and focus on 11-y variability. The analysis shows that the star changes the UV spectral distribution during 11-y cycle with a different behaviour during the descending phase of cycle 23 and growing phase of cycle 24. The observed UV major evolution can provide empirically-motivated UV predictions over the cycles. On the other hand, the observed minor differences during the ascending and descending phase of solar cycle can be attributed to physical changes in solar emission or described by an uncorrected time-dependent performance of SOLSTICE UV channels. We shortly discuss both possibilities.

  13. Intelligent Video Traffic Smooth Mechanism for Multimedia Communication

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A principal challenge in supporting real-time video services over ATM is the need to provide synchronous play-out in the face of stochastic end-to-end network delays. In this paper, an intelligent traffic smooth mechanism ( ITSM ) is proposed to meet the continuity requirement which is composed of a back-propagation neural network ( BPNN ) traffic predictor, a play-out buffer, and a fuzzy neural network ( FNN ) based play-out rate determinator. The BPNN traffic predictor online predicts the mean packet rate of the traffic in the future interval ( FI ) and the FNN is designed to adaptively determinate the play-out time according to the number of packets in the buffer and the traffic character predicted. Simulation results show that compared to the window mechanism, ITSM achieves high continuity with accepted delay. Furthermore, ITSM can be adaptively modified to meet the QoS of different kinds of services by FNN parameter training.

  14. SUBSTATIATION AND CHOICE OF ROAD TRAFFIC AUTOMATIC CONTROL SYSTEM SPECIAL FACILITY

    OpenAIRE

    Shasha, I.

    2007-01-01

    The analysis of potential ecological hazard usage efficiency and reduction of avarage length of human life for road traffic management has been done. It has been proved that the application of these characteristics will be efficient in case of high traffic volume. It is suggested to use the total value of road vehicle delay time at urban road network crossings as an universal special function of road traffic management optimization. During one traffic control cycle.

  15. Distributed learning and multi-objectivity in traffic light control

    Science.gov (United States)

    Brys, Tim; Pham, Tong T.; Taylor, Matthew E.

    2014-01-01

    Traffic jams and suboptimal traffic flows are ubiquitous in modern societies, and they create enormous economic losses each year. Delays at traffic lights alone account for roughly 10% of all delays in US traffic. As most traffic light scheduling systems currently in use are static, set up by human experts rather than being adaptive, the interest in machine learning approaches to this problem has increased in recent years. Reinforcement learning (RL) approaches are often used in these studies, as they require little pre-existing knowledge about traffic flows. Distributed constraint optimisation approaches (DCOP) have also been shown to be successful, but are limited to cases where the traffic flows are known. The distributed coordination of exploration and exploitation (DCEE) framework was recently proposed to introduce learning in the DCOP framework. In this paper, we present a study of DCEE and RL techniques in a complex simulator, illustrating the particular advantages of each, comparing them against standard isolated traffic actuated signals. We analyse how learning and coordination behave under different traffic conditions, and discuss the multi-objective nature of the problem. Finally we evaluate several alternative reward signals in the best performing approach, some of these taking advantage of the correlation between the problem-inherent objectives to improve performance.

  16. Modeling of urban traffic networks with lattice Boltzmann model

    Science.gov (United States)

    Meng, Jian-ping; Qian, Yue-hong; Dai, Shi-qiang

    2008-02-01

    It is of great importance to uncover the characteristics of traffic networks. However, there have been few researches concerning kinetics models for urban traffic networks. In this work, a lattice Boltzmann model (LBM) for urban traffic networks is proposed by incorporating the ideas of the Biham-Middleton-Levine (BML) model into the LBM for road traffic. In the present model, situations at intersections with the red and green traffic signals are treated as a kind of boundary conditions varying with time. Thus, the urban traffic network could be described in the mesoscopic level. By performing numerical simulations under the periodic boundary conditions, the behavior of average velocity is investigated in detail. The numerical results agree quite well with those given by the Chowdhury-Schadschneider (ChSch) model (Chowdhury D. and Schadschneider A., Phys. Rev. E, 59 (1999) R1311). Furthermore, the statistical noise is reduced in this discrete kinetics model, thus, the present model has considerably high computational efficiency.

  17. Analysis of Dynamic Road Traffic Congestion Control (DRTCC Techniques

    Directory of Open Access Journals (Sweden)

    Pardeep Mittal

    2015-10-01

    Full Text Available : Dynamic traffic light control at intersection has become one of the most active research areas to develop the Dynamic transportation systems (ITS. Due to the consistent growth in urbanization and traffic congestion, such a system was required which can control the timings of traffic lights dynamically with accurate measurement of traffic on the road. In this paper, analysis of all the techniques that has been developed to automate the traffic lights has been done.. The efficacy of all the techniques has been evaluated, using MATLAB software. After comparison of artificial intelligent techniques , it is found that image mosaicking technique is quite effective (in terms of improving moving time and reducing waiting time for the control of the traffic signals to control congestion on the road.

  18. Characterization of P2P IPTV Traffic: Scaling Analysis

    CERN Document Server

    Silverston, Thomas; Salamatian, Kave

    2007-01-01

    P2P IPTV applications arise on the Internet and will be massively used in the future. It is expected that P2P IPTV will contribute to increase the overall Internet traffic. In this context, it is important to measure the impact of P2P IPTV on the networks and to characterize this traffic. During the 2006 FIFA World Cup, we performed an extensive measurement campaign. We measured network traffic generated by broadcasting soccer games by the most popular P2P IPTV applications, namely PPLive, PPStream, SOPCast and TVAnts. From the collected data, we characterized the P2P IPTV traffic structure at different time scales. To the best of our knowledge, this is the first work, which presents a complete multiscale analysis of the P2P IPTV traffic. Our observations show that the network traffic has not the same scale behavior whether the applications use TCP or UDP. For all the applications, the download traffic is different from the upload traffic and the signaling traffic has an impact on the download traffic.

  19. Plasticity in the vocalizations of anurans in response to traffic noise

    Science.gov (United States)

    Cunnington, Glenn M.; Fahrig, Lenore

    2010-09-01

    Many species use acoustic signals to attract mates, and such signals can be degraded by anthropogenic noise. Anuran abundance has been shown to be negatively correlated with road traffic which could be due in part to the interruption of mate attraction by traffic noise. However, this impact could be small if anurans can alter their vocalization characteristics to avoid masking of their calls by traffic noise. We predicted that: (i) anuran vocalization characteristics (dominant frequency, mean amplitude and call rate) should be different in areas with different traffic noise levels; (ii) increases in traffic noise can cause immediate changes in amphibian vocalization characteristics; (iii) these altered vocalizations are similar to those at high traffic sites. To test the first prediction we compared vocalizations of four species of anuran at breeding sites in locations with low traffic noise vs. sites with high traffic noise. For the second prediction we broadcast traffic noise at low traffic (quiet) sites, and compared the anuran vocalizations before vs. during the broadcast traffic noise. For the third prediction we compared vocalizations at high traffic sites to those produced at low traffic sites while broadcasting traffic noise. Three species of anurans found at locations with low traffic noise produced vocalizations with different characteristics than individuals of the same species found in locations with high traffic noise. Broadcast traffic noise immediately altered amphibian vocalization characteristics such that they became similar to those of the same species found in locations with high traffic noise. We conclude that plasticity in the vocalizations of anurans allows for the maintenance of acoustic communication in the presence of traffic noise.

  20. 49 CFR 192.325 - Underground clearance.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Underground clearance. 192.325 Section 192.325... Lines and Mains § 192.325 Underground clearance. (a) Each transmission line must be installed with at least 12 inches (305 millimeters) of clearance from any other underground structure not associated...

  1. 32 CFR 154.48 - Issuing clearance.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Issuing clearance. 154.48 Section 154.48 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM REGULATION Issuing Clearance and Granting Access § 154.48 Issuing clearance. (a) Authorities designated in paragraph...

  2. 30 CFR 56.11010 - Stairstep clearance.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Stairstep clearance. 56.11010 Section 56.11010 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Travelways § 56.11010 Stairstep clearance. Vertical clearance...

  3. 14 CFR 25.925 - Propeller clearance.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Propeller clearance. 25.925 Section 25.925 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant General § 25.925 Propeller clearance. Unless smaller clearances are substantiated,...

  4. 76 FR 47917 - Lead; Clearance and Clearance Testing Requirements for the Renovation, Repair, and Painting Program

    Science.gov (United States)

    2011-08-05

    ... August 5, 2011 Part IV Environmental Protection Agency 40 CFR Part 745 Lead; Clearance and Clearance... AGENCY 40 CFR Part 745 RIN 2070-AJ57 Lead; Clearance and Clearance Testing Requirements for the... 2008 Lead Renovation, Repair, and Painting Program (RRP) rule, the EPA agreed to propose a number...

  5. VBR video traffic models

    CERN Document Server

    Tanwir, Savera

    2014-01-01

    There has been a phenomenal growth in video applications over the past few years. An accurate traffic model of Variable Bit Rate (VBR) video is necessary for performance evaluation of a network design and for generating synthetic traffic that can be used for benchmarking a network. A large number of models for VBR video traffic have been proposed in the literature for different types of video in the past 20 years. Here, the authors have classified and surveyed these models and have also evaluated the models for H.264 AVC and MVC encoded video and discussed their findings.

  6. Road Traffic Injuries

    Institute of Scientific and Technical Information of China (English)

    WANG Zheng-guo

    2005-01-01

    @@ As everybody knows that automobiles have been greatly changing our life. However, everything has two sides, motor vehicles have also caused a huge number of people's deaths, injuries and property damage. Traffic crashes are perhaps the number one public health problem in developed countries [1]. In the United States, pre-retirement years of life lost in traffic crashes are more than that of the two combined leading diseases: cancer and heart disease [1]. Today road traffic crash (RTC) ranks 11th in leading cause of death and accounts for 2.1% of all deaths globally.

  7. Analysis of X-ray induced cell-cycle perturbations in mouse osteosarcoma cells: a two-signal cell-cycle model

    International Nuclear Information System (INIS)

    The effects of X-irradiation on mouse osteosarcoma cells have been studied by time-lapse cinematography and the resulting pedigrees have been analysed statistically. It is shown that the irradiation treatment causes three types of cell kinetic lesions: cell death (disintegration), cell sterilization (failure to divide) and proliferation delay. The first two lesions are the most important with regard to survival of the irradiated cell in a clonal assay. Of these two lesions, sterilization appears to be highly correlated for sister cells, while this is not true for cell disintegration. This indicates that cell survival in a clonal assay may be a function of the ratio of the incidences of these two types of lesions. The X-ray-induced proliferation delay was studied in terms of intermitotic time distributions, mother-daughter correlation and sibling correlation in relation to the current cell-cycle phase at the time of treatment. This analysis shows that the effects of irradiation on these cell-cycle characteristics is highly cell-cycle-dependent. A qualitative model to account for the observations is presented. (author)

  8. Signals involved in T cell activation. II. Distinct roles of intact accessory cells, phorbol esters, and interleukin 1 in activation and cell cycle progression of resting T lymphocytes

    Energy Technology Data Exchange (ETDEWEB)

    Davis, L.; Lipsky, P.E.

    1986-05-15

    The signals involved in the initiation of mitogen-induced activation of resting guinea pig T cells were examined. The combination of phytohemagglutinin (PHA) and 4..beta..-phorbol 12-myristate 13-acetate (PMA) stimulated DNA synthesis by accessory cell (AC)-depleted T cells cultured at high density, but the use of low density cultures indicated that intact AC were absolutely necessary for PHA-stimulated T cell DNA synthesis even in the presence of PMA, interleukin 1 (IL 1), or interleukin 2 (IL 2). In contrast, AC-depleted T cells were able to respond to the combination of the calcium ionophore, ionomycin, and PMA regardless of the cell density at which they were cultured. Results of cell cycle analysis support the conclusion that intact AC, IL 1, and a PMA-like signal play distinct roles in the progression of mitogen stimulated T cells through the first round of the cell cycle.

  9. Vehicular Traffic Flow Controlled by Traffic Light on a Street with Open Boundaries

    Science.gov (United States)

    Mhirech, Abdelaziz; Ismaili, Assia Alaoui

    2013-08-01

    The Nagel-Schreckenberg (NS) cellular automata (CA) model for describing the vehicular traffic flow in a street with open boundaries is studied. To control the traffic flow, a traffic signalization light operating for a fixed-time scheme is placed in the middle of the street. Extensive Monte Carlo simulations are carried out to calculate various model characteristics. Essentially, we investigate the formation of the cars queue behind traffic light dependence on the duration of green light Tg, injecting and extracting probabilities α and β, respectively. Two phases of average training queues were found. Besides, the dependence of car accident probability per site and per time step on Tg, α and β is computed.

  10. Self-learning traffic signal control method of isolated intersection combining Q-learning and fuzzy logic%结合Q学习和模糊逻辑的单路口交通信号自学习控制方法

    Institute of Scientific and Technical Information of China (English)

    何兆成; 佘锡伟; 杨文臣; 陈宁宁

    2011-01-01

    To address the dynamics and uncertainty in unban transportation system, this paper proposed a traffic signal control system based on reinforcement learning, which was suitable for real-time control in isolated intersection.The proposed method was capable of online learning through a combination of BP neural network and Q-learning algorithm.Furthermore, due to the multi-objective property in traffic signal control, this paper developed a reward design method for Q-learning based on fuzzy logic.Conducted simulated experiments in three traffic scenarios, using the Paramics microscopic traffic simulation software.Experimental results show that the proposed method has high control efficiency in different traffic scenarios, and is significantly better than fixed timing control method.%针对城市交通系统的动态性和不确定性,提出了基于强化学习的信号交叉口智能控制系统结构,对单交叉口动态实时控制进行了研究.将BP神经网络与Q学习算法相结合实现了路口的在线学习.同时,针对交通信号控制的多目标评价特征,采用基于模糊逻辑的Q学习奖惩信号设计方法,实施对交通信号的优化控制.最后,在三种交通场景下,应用Paramics微观交通仿真软件对典型十字路口进行仿真实验.结果表明,该方法对不同交通场景下的突变仍可保持较高的控制效率,控制效果明显优于定时控制.

  11. Traffic accident injuries in a referral Orthopedic Hospital in North West of Iran during summer 2009

    Directory of Open Access Journals (Sweden)

    Amir Mohammad Navali

    2015-03-01

    Full Text Available Introduction: Road traffic injuries are a major public health problem, requiring huge efforts for effective and sustainable prevention. Because of the high occurrence of traffic accidents in Iran, basic data acquisition is highly needed to implement prevention plans. The present research is conducted as an epidemiological study of the traffic accident victims referred to a referral orthopedic center in North West of Iran. Methods: A cross-sectional study was conducted during a 3 months period from June to September 2009 in Tabriz, Iran. A total of 16681 patients were admitted to the emergency ward, and 3246 patients (19.5% were hospitalized during this period because of traffic related injuries. After randomization, 630 cases were selected to be enrolled in the study. The location of an accident, position of road users, type of crashed vehicle, cause of accident, type of injury, time interval from accident to hospitalization and treatment outcome were recorded. Statistical analyses were carried out using SPSS software. Results: The mean age of the patients was 31 years (range, 6 months to 98 years and 77.0% of patients (468 cases were men. A total of 193 (36.6% patients sustained traffic accident in open roads and 335 (63.4% in urban corridors. In 67 (12.9% of accidents, there was only a single occupant in the vehicle. The time interval between the accident and admission was 6.6 ± 3.2 hours. Of the 608 cases, 45.7% were drivers, 30.3% passengers, and 24.0% pedestrians. Most cases of the car accident happened in urban areas, and the male victims were largely in the driver group. The most frequent type of injury was knee, leg and head trauma. Conclusion: The large number of traffic-related injuries admitted to our emergency ward that comprise mostly young adults should be considered as an alarming signal to policy makers and health providers in our province. Strict control on drivers’ behavior should be taken into account if increasing human

  12. Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children

    Directory of Open Access Journals (Sweden)

    Sijuade Abayomi

    2010-02-01

    Full Text Available Abstract Background Drug resistance in Plasmodium falciparum is common in many endemic and other settings but there is no clear recommendation on when to change therapy when there is delay in parasite clearance after initiation of therapy in African children. Methods The factors contributing to delay in parasite clearance, defined as a clearance time > 2 d, in falciparum malaria were characterized in 2,752 prospectively studied children treated with anti-malarial drugs between 1996 and 2008. Results 1,237 of 2,752 children (45% had delay in parasite clearance. Overall 211 children (17% with delay in clearance subsequently failed therapy and they constituted 72% of those who had drug failure, i.e., 211 of 291 children. The following were independent risk factors for delay in parasite clearance at enrolment: age less than or equal to 2 years (Adjusted odds ratio [AOR] = 2.13, 95% confidence interval [CI]1.44-3.15, P 50,000/ul (AOR = 2.21, 95% CI = 1.77-2.75, P 20000/μl a day after treatment began, were independent risk factors for delay in clearance. Non-artemisinin monotherapies were associated with delay in clearance and treatment failures, and in those treated with chloroquine or amodiaquine, with pfmdr 1/pfcrt mutants. Delay in clearance significantly increased gametocyte carriage (P Conclusion Delay in parasite clearance is multifactorial, is related to drug resistance and treatment failure in uncomplicated malaria and has implications for malaria control efforts in sub-Saharan Africa.

  13. Contributions of dynamic environmental signals during life-cycle transitions to early life-history traits in lodgepole pine (Pinus contorta Dougl.)

    OpenAIRE

    Liu, Yang; Wang, Tongli; El-Kassaby, Yousry A.

    2016-01-01

    Environmental signals are important triggers in the life-cycle transitions and play a crucial role in the life-history evolution. Yet very little is known about the leading ecological factors contributing to the variations of life-history traits in perennial plants. This paper explores both the causes and consequences for the evolution of life-history traits (i.e., seed dormancy and size) in lodgepole pine (Pinus contorta Dougl.) across British Columbia (B.C.), Canada. We se...

  14. Traffic Accident Prediction Model Implementation in Traffic Safety Management

    OpenAIRE

    Wen, Keyao

    2009-01-01

    As one of the highest fatalities causes, traffic accidents and collisions always requires a large amounteffort to be reduced or prevented from occur. Traffic safety management routines therefore always needefficient and effective implementation due to the variations of traffic, especially from trafficengineering point of view apart from driver education.Traffic Accident Prediction Model, considered as one of the handy tool of traffic safety management,has become of well followed with interest...

  15. CONTROLLING TRAFFIC FLOW IN MULTILANE-ISOLATED INTERSECTION USING ANFIS APPROACH TECHNIQUES

    Directory of Open Access Journals (Sweden)

    G. R. LAI

    2015-08-01

    Full Text Available Many controllers have applied the Adaptive Neural-Fuzzy Inference System (ANFIS concept for optimizing the controller performance. However, there are less traffic signal controllers developed using the ANFIS concept. ANFIS traffic signal controller with its fuzzy rule base and its ability to learn from a set of sample data could improve the performance of Existing traffic signal controlling system to reduce traffic congestions at most of the busy traffic intersections in city such as Kuala Lumpur, Malaysia. The aim of this research is to develop an ANFIS traffic signals controller for multilane-isolated four approaches intersections in order to ease traffic congestions at traffic intersections. The new concept to generate sample data for ANFIS training is introduced in this research. The sample data is generated based on fuzzy rules and can be analysed using tree diagram. This controller is simulated on multilane-isolated traffic intersection model developed using M/M/1 queuing theory and its performance in terms of average waiting time, queue length and delay time are compared with traditional controllers and fuzzy controller. Simulation result shows that the average waiting time, queue length, and delay time of ANFIS traffic signal controller are the lowest as compared to the other three controllers. In conclusion, the efficiency and performance of ANFIS controller are much better than that of fuzzy and traditional controllers in different traffic volumes.

  16. Turning Traffic Jams to Jelly

    Institute of Scientific and Technical Information of China (English)

    LI LI

    2010-01-01

    @@ Beijing, known for having the worst traffic in China, is brewing up a traffic plan with the harshest ever measures to ensure smooth traffic flow as the capital's gridlock during rush hour and private car sales soar. On December 13, the Beijing Municipal Government started soliciting public opinions for a draft plan designed to relieve the city's traffic problems.

  17. Traffic-Adaptive Routing

    OpenAIRE

    Kammenhuber, Nils

    2011-01-01

    Despite the bursty and highly volatile traffic, routing in the Internet today is optimised only on coarse time scales, as load-adaptive routing is known to induce performance deterioration by causing massive oscillations. We describe ReplEx, an universally applicable distributed algorithm for dynamic routing/traffic engineering, which is based on game theory. We show through extensive realistic simulations that ReplEx does not oscillate, and that it achieves performance gains comparable to tr...

  18. Traffic Management Systems

    OpenAIRE

    Wei Chen; David Levinson

    2004-01-01

    This study uses regression analysis to evaluate long-run traffic management system performance. Three important traffic management systems in the Twin Cities metro area - Ramp Metering, Variable Message Signs (VMS), and Freeway Service Patrol (the Highway Helper Program) were evaluated with multiple regression models to predict link speed and incident rate. We find that ramp meters increase freeway link speed and reduce incident rate. Freeway Service Patrols increase link speed when incidents...

  19. Penalties in traffic.

    OpenAIRE

    2009-01-01

    Traffic offenders are penalized in various ways: fines, (temporary) driving licence suspensions, confiscation of their vehicles, penalty points, mandatory participation in rehabilitation programmes, prison sentences or community service. The aim of penalties is to punish offenders, to protect society and to influence the behaviour of offenders and all citizens (prevention). Many studies have found that the combination of enforcement and penalties prevent the violation of traffic regulations a...

  20. Impaired tracheobronchial clearance in bronchiectasis.

    OpenAIRE

    Currie, D C; Pavia, D; Agnew, J E; Lopez-Vidriero, M T; Diamond, P D; Cole, P J; Clarke, S. W.

    1987-01-01

    Tracheobronchial clearance was measured by a radioaerosol technique in 12 patients with bronchiectasis, seven patients with chronic obstructive lung disease expectorating mucoid sputum daily (group X), eight patients with chronic obstructive lung disease but negligible sputum expectoration (group Y), and 10 healthy subjects. The patients with bronchiectasis all expectorated purulent sputum daily (mean wet weight 47 g/day), had reduced forced expiratory volume in one second (FEV1) (mean 47.5% ...

  1. The interval ordering problem

    CERN Document Server

    Dürr, Christoph; Spieksma, Frits C R; Nobibon, Fabrice Talla; Woeginger, Gerhard J

    2011-01-01

    For a given set of intervals on the real line, we consider the problem of ordering the intervals with the goal of minimizing an objective function that depends on the exposed interval pieces (that is, the pieces that are not covered by earlier intervals in the ordering). This problem is motivated by an application in molecular biology that concerns the determination of the structure of the backbone of a protein. We present polynomial-time algorithms for several natural special cases of the problem that cover the situation where the interval boundaries are agreeably ordered and the situation where the interval set is laminar. Also the bottleneck variant of the problem is shown to be solvable in polynomial time. Finally we prove that the general problem is NP-hard, and that the existence of a constant-factor-approximation algorithm is unlikely.

  2. Target-induced formation of gold amalgamation on DNA-based sensing platform for electrochemical monitoring of mercury ion coupling with cycling signal amplification strategy

    International Nuclear Information System (INIS)

    Graphical abstract: -- Highlights: •We report a new electrochemical sensing protocol for the detection of mercury ion. •Gold amalgamation on DNA-based sensing platform was used as nanocatalyst. •The signal was amplified by cycling signal amplification strategy. -- Abstract: Heavy metal ion pollution poses severe risks in human health and environmental pollutant, because of the likelihood of bioaccumulation and toxicity. Driven by the requirement to monitor trace-level mercury ion (Hg2+), herein we construct a new DNA-based sensor for sensitive electrochemical monitoring of Hg2+ by coupling target-induced formation of gold amalgamation on DNA-based sensing platform with gold amalgamation-catalyzed cycling signal amplification strategy. The sensor was simply prepared by covalent conjugation of aminated poly-T(25) oligonucleotide onto the glassy carbon electrode by typical carbodiimide coupling. Upon introduction of target analyte, Hg2+ ion was intercalated into the DNA polyion complex membrane based on T–Hg2+–T coordination chemistry. The chelated Hg2+ ion could induce the formation of gold amalgamation, which could catalyze the p-nitrophenol with the aid of NaBH4 and Ru(NH3)63+ for cycling signal amplification. Experimental results indicated that the electronic signal of our system increased with the increasing Hg2+ level in the sample, and has a detection limit of 0.02 nM with a dynamic range of up to 1000 nM Hg2+. The strategy afforded exquisite selectivity for Hg2+ against other environmentally related metal ions. In addition, the methodology was evaluated for the analysis of Hg2+ in spiked tap-water samples, and the recovery was 87.9–113.8%

  3. Ant traffic rules.

    Science.gov (United States)

    Fourcassié, Vincent; Dussutour, Audrey; Deneubourg, Jean-Louis

    2010-07-15

    Many animals take part in flow-like collective movements. In most species, however, the flow is unidirectional. Ants are one of the rare group of organisms in which flow-like movements are predominantly bidirectional. This adds to the difficulty of the task of maintaining a smooth, efficient movement. Yet, ants seem to fare well at this task. Do they really? And if so, how do such simple organisms succeed in maintaining a smooth traffic flow, when even humans experience trouble with this task? How does traffic in ants compare with that in human pedestrians or vehicles? The experimental study of ant traffic is only a few years old but it has already provided interesting insights into traffic organization and regulation in animals, showing in particular that an ant colony as a whole can be considered as a typical self-organized adaptive system. In this review we will show that the study of ant traffic can not only uncover basic principles of behavioral ecology and evolution in social insects but also provide new insights into the study of traffic systems in general. PMID:20581264

  4. ON INTERVAL ESTIMATING REGRESSION

    Directory of Open Access Journals (Sweden)

    Marcin Michalak

    2014-06-01

    Full Text Available This paper presents a new look on the well-known nonparametric regression estimator – the Nadaraya-Watson kernel estimator. Though it was invented 50 years ago it still being applied in many fields. After these yearsfoundations of uncertainty theory – interval analysis – are joined with this estimator. The paper presents the background of Nadaraya-Watson kernel estimator together with the basis of interval analysis and shows the interval Nadaraya-Watson kernel estimator.

  5. Possible Causes & Solutions of Traffic Jam and Their Impact on the Economy of Dhaka City

    OpenAIRE

    Khaled Mahmud; Khonika Gope; Syed Mustafizur Rahman Chowdhury

    2012-01-01

    Dhaka, capital of Bangladesh, is the most densely populated city in the whole world. More than twelve million people live in Dhaka city. Day by day the number is increasing and most part of Dhaka is badly affected by huge traffic jam. Faulty traffic signaling systems, inadequate manpower, narrow road spaces and overtaking tendency of drivers create pro-longed traffic congestions. Due to traffic jam a substantial portion of working hours have to be left on streets which indirectly put adverse ...

  6. Disruption of the Hedgehog Signaling Pathway Contributes to the Hair Follicle Cycling Deficiency in Vdr Knockout Mice

    OpenAIRE

    Teichert, Arnaud; Elalieh, Hashem; Bikle, Daniel

    2010-01-01

    Mice null for the Vitamin D receptor (VdrKO) have a disrupted first hair follicle cycle and aborted subsequent hair follicle cycling. We examined the expression of different markers and mediators of hair follicle cycling in the hair follicle of the VdrKO mouse during days 13–22 when the hair follicle normally initiates and completes the first catagen. We compared the expression of those genes in mice with a nonsense mutation in hairless (Rhino), which have a similar alopecia phenotype, and to...

  7. Interval graph limits

    CERN Document Server

    Diaconis, Persi; Janson, Svante

    2011-01-01

    We work out the graph limit theory for dense interval graphs. The theory developed departs from the usual description of a graph limit as a symmetric function $W(x,y)$ on the unit square, with $x$ and $y$ uniform on the interval $(0,1)$. Instead, we fix a $W$ and change the underlying distribution of the coordinates $x$ and $y$. We find choices such that our limits are continuous. Connections to random interval graphs are given, including some examples. We also show a continuity result for the chromatic number and clique number of interval graphs. Some results on uniqueness of the limit description are given for general graph limits.

  8. Design of optimized Interval Arithmetic Multiplier

    Directory of Open Access Journals (Sweden)

    Rajashekar B.Shettar

    2011-07-01

    Full Text Available Many DSP and Control applications that require the user to know how various numericalerrors(uncertainty affect the result. This uncertainty is eliminated by replacing non-interval values withintervals. Since most DSPs operate in real time environments, fast processors are required to implementinterval arithmetic. The goal is to develop a platform in which Interval Arithmetic operations areperformed at the same computational speed as present day signal processors. So we have proposed thedesign and implementation of Interval Arithmetic multiplier, which operates with IEEE 754 numbers. Theproposed unit consists of a floating point CSD multiplier, Interval operation selector. This architectureimplements an algorithm which is faster than conventional algorithm of Interval multiplier . The costoverhead of the proposed unit is 30% with respect to a conventional floating point multiplier. Theperformance of proposed architecture is better than that of a conventional CSD floating-point multiplier,as it can perform both interval multiplication and floating-point multiplication as well as Intervalcomparisons

  9. ETFRC: Enhanced TFRC for Media Traffic over Internet

    Directory of Open Access Journals (Sweden)

    Mohammad A. Talaat

    2011-08-01

    Full Text Available The evident increase in media traffic over Internet is expected to worsen its congestion state. TCP-friendly rate control protocol TFRC is one of the most promising congestion control techniques developed so far. TFRC has been thoroughly tested in terms of being TCP-friendly, responsive, and fair. Yet, its impact on the visual quality and the peak signal-to- noise ratio PSNR of the media traffic traversing Internet is still questionable. In this paper we aimed to point out the enhancements required for TFRC that enables producing the maximum PSNR value for Internet media traffic. Firstly, we suspected the default value of n that represents the number of loss intervals used in calculating the loss event rate in the TFRC equation. This value is recommended to be set to 8 according to the latest RFC of TFRC. We investigated the effect of modifying the TFRC mechanism on the resulting PSNR of the transmitted video over Internet using TFRC via switching n across the values from 2 to 16. We investigated the effect of such variation over a simulated network environment to study its effect on the resulting PSNR for a number of arbitrary video sequences. Our simulations results showed that running TFRC with n=11 led to reaching the maximum PSNR values among all the examined values of n including its default value. Secondly, we tested the impact on the PSNR of another modification in the TFRC mechanism via switching both values of n and Nfb which is frequency of feedback messages sent by TFRC receiver to its sender every round-trip time RTT. The default value of Nfb is 1; hence we scanned every possible combination of n and Nfb ranging from 2 to 16, and from 1 to 4, respectively and recorded the produced PSNR. It was obvious that several other combinations of n and Nfb produced higher PSNR values other than their default values in the request for comment RFC of TFRC. We hereby suggest using an enhanced TFRC that we abbreviated as ETFRC which has the values

  10. A Cooperative Traffic Control Strategy

    OpenAIRE

    BORG, Dora Lee; Bhouri, Neila; SCERRI, Kenneth

    2015-01-01

    With one-third of the global population living in cities by 2030 and the need for mobility fueling traffic growth all over the world, the traffic congestion problem in major cities is becoming more and more acute. Besides economic losses, traffic congestion has detrimental effects on our standard of living and on the environment. A viable solution to the traffic congestion problem is intelligent traffic control. The main aim of this work is to test a Model Predictive Control Strategy (MPC) on...

  11. Traffic violation alert and management

    OpenAIRE

    Aliane, Nourdine; Fernández Andrés, Javier; Bemposta Rosende, Sergio; Mata Ortega, Mario

    2011-01-01

    The present paper presents an in-vehicle system for traffic violation alert and management. The system hardware consists of a combination of an on-board computer vision system for traffic sign detection and recognition with a data recorder device for traffic violation alert and management. At present, traffic violations are only focused on three signs: namely speed limit, stop sign, and forbidden turning. The system is designed to warn drivers about potential traffic violations by emitting ac...

  12. Lock Traffic Signal Stations - USACE IENC

    Data.gov (United States)

    Department of Homeland Security — These inland electronic Navigational charts (IENCs) were developed from available data used in maintenance of Navigation channels. Users of these IENCs should be...

  13. Trajectories for Novel and Detailed Traffic Information

    DEFF Research Database (Denmark)

    Krogh, Benjamin Bjerre; Andersen, Ove; Torp, Kristian

    2012-01-01

    Trajectories based on GPS tracks have been studied for a number of years but only to a limited degree been used for analyzing and monitoring traffic. This paper shows how novel and important information about traffic can be computed from trajectories. Concretely the paper proposes to compute the...... central metric free-flow speed from trajectories, instead of using point-based measurements such as induction-loops. This free-flow speed is widely used to compute and monitor the congestion level. The paper argues that the actual travel-time is a more accurate metric. The paper suggests a novel approach...... to analyzing individual intersections that enables traffic analysts to compute queue lengths and estimated time to pass an intersection. Finally, the paper uses associative rule mining for evaluating green waves on road stretches. Such information can be used to verify that signalized intersections...

  14. [Cycling in Zagreb].

    Science.gov (United States)

    Matos, Stipan; Krapac, Ladislav; Krapac, Josip

    2007-01-01

    Cycling in Zagreb, as means of urban transport inside and outside the city, has a bright past, hazy presence but a promising future. Every day, aggressive citizens who lack urban traffic culture mistreat many cyclists but also many pedestrians. Sedentary way of living, unhealthy eating habits and inadequate recreation would surely be reduced if Zagreb had a network of cycling tracks (190 cm) or lanes (80 cm). Main city roads were constructed at the beginning of the 20th century. Today, the lack of cycling tracks is particularly evident in terms of missing connections between northern and southern parts of the city. Transportation of bikes in public vehicles, parking of bikes as well as cycling along the foot of the mountains Medvednica and Zumberacko gorje is not adequately organized. Better organization is necessary not only because of the present young generation but also because of the young who will shortly become citizens of the EU, where cycling is enormously popular. Cycling tourism is not known in Zagreb, partly due to inadequate roads. The surroundings of Zagreb are more suitable for cycling tourism and attractive brochures and tourist guides offer information to tourists on bikes. Professional, acrobatic and sports cycling do not have a tradition in Zagreb and in Croatia. The same holds true for recreational cycling and indoor exercise cycling. The authors discuss the impact of popularization of cycling using print and electronic media. The role of district and local self-government in the construction and improvement of traffic roads in Zagreb is very important. It is also significant for the implementation of legal regulations that must be obeyed by all traffic participants in order to protect cyclists, the most vulnerable group of traffic participants besides passengers. Multidisciplinary action of all benevolent experts would surely increase safety and pleasure of cycling in the city and its surroundings. This would also help reduce daily stress and

  15. BIRTH INTERVAL AMONG NOMAD WOMEN

    Directory of Open Access Journals (Sweden)

    E.Keyvan

    1976-06-01

    Full Text Available To have an, idea about the relation between the length of birth interval and lactation, and birth control program this study have been done. The material for such analysis was nomad women's fertility history that was in their reproductive period (15-44. The material itself was gathered through a health survey. The main sample was composed of 2,165 qualified women, of whom 49 due to previous or presently using contraceptive methods and 10 for the lack of enough data were excluded from 'this study. Purpose of analysis was to find a relation between No. of live births and pregnancies with total duration of married life (in other word, total months which the women were at risk of pregnancy. 2,106 women which their fertility history was analyzed had a totally of272, 502 months married life. During this time 8,520 live births did occurred which gave a birth interval of 32 months. As pregnancy termination could be through either live birth, still birth or abortion (induced or spontaneous, bringing all together will give No. of pregnancies which have occurred during this period (8,520 + 124 + 328 = 8,972 with an average of interpregnancy interval of 30.3 months. Considering the length of components of birth interval: Post partum amenorrhea which depends upon lactation. - Anovulatory cycles (2 month - Ooulatory exposure, in the absence of contraceptive methods (5 months - Pregnancy (9 months.Difference between the length, of birth interval from the sum of the mentioned period (except the first component, (2 + 5+ 9 = 16 will be duration of post partum amenorrhea (32 - 16 = 16, or in other word duration of breast feeding among nomad women. In this study it was found that, in order to reduce birth by 50% a contraceptive method with 87% effectiveness is needed.

  16. Development of the clearance level verification evaluation system. 2. Construction of the clearance data management system

    International Nuclear Information System (INIS)

    Clearance is defined as the removal of radioactive materials or radioactive objects within authorized practices from any further regulatory control by the regulatory body. In Japan, clearance level and a procedure for its verification has been introduced under the Laws and Regulations, and solid clearance wastes inspected by the national authority can be handled and recycled as normal wastes. The most prevalent type of wastes have generated from the dismantling of nuclear facilities, so the Japan Atomic Energy Agency (JAEA) has been developing the Clearance Level Verification Evaluation System (CLEVES) as a convenient tool. The Clearance Data Management System (CDMS), which is a part of CLEVES, has been developed to support measurement, evaluation, making and recording documents with clearance level verification. In addition, validation of the evaluation result of the CDMS was carried out by inputting the data of actual clearance activities in the JAEA. Clearance level verification is easily applied by using the CDMS for the clearance activities. (author)

  17. On Movement of Emergency Services amidst Urban Traffic

    Directory of Open Access Journals (Sweden)

    Manoj Bode

    2015-12-01

    Full Text Available Managing traffic in urban areas is a complex affair. The same becomes more challenging when one needs to take into account the prioritized movement of emergency vehicles along with the normal flow of traffic. Although, mechanisms have been proposed to model intelligent traffic management systems, a concentrated effort to facilitate the movement of emergency services amongst urban traffic is yet to be formalized. This paper proposes a distributed multi-agent based mechanism to create partial green corridors for the movement of emergency service vehicles such as ambulances, fire brigade and police vans, amidst urban traffic. The proposed approach makes se of a digital network of traffic signal nodes equipped with traffic sensors and an agent framework to autonomously extend, maintain and manage partial green corridors for such emergency vehicles. The approach was emulated using Tartarus, an agent framework over a LAN. The results gathered under varying traffic conditions and also several emergency vehicles, validate the performance of this approach and its effects on the movement of normal traffic. Comparisons with the non-prioritized and full green corridor approaches indicate that the proposed partial corridor approach outperforms the rest.

  18. MATLAB Simulation of Fuzzy Traffic Controller for Multilane Isolated Intersection

    Directory of Open Access Journals (Sweden)

    Azura Che Soh/Lai Guan Rhung

    2010-07-01

    Full Text Available This paper presents a MATLAB simulation of fuzzy traffic controller for controlling traffic flow at multilane isolated signalized intersection. The controller is developed based on the waiting time and vehicles queue length at current green phase, and vehicles queue lengths at the other phases. For control strategy, the controllercontrols the traffic light timings and phase sequence to ensure smooth flow of traffic with minimal waiting time, queue length and delay time. In this research, the isolated intersection model used consists of two lanes in each approach. Each approach has two different values of vehicles queue length and waiting time, respectively, at the intersection. The maximum values of vehicles queue length and waiting times are selected as the inputs to controller for optimized control of traffic flows at the intersection. A traffic model and fuzzy traffic controller are developed to evaluate the performance of traffic controllers underdifferent conditions. In the end, by comparing the experimental result obtained by the vehicle-actuated controller (VAC and fuzzy traffic controller (FTC which improves significant performance for intersections, we confirmed the efficiency of our intelligent controller based fuzzy inference system.

  19. Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells

    International Nuclear Information System (INIS)

    Highlights: • Wogonin inhibited HCT116 cells growth and arrested at G1 phase of the cell cycle. • Wogonin down-regulated the canonical Wnt/β-catenin signaling pathway. • Wogonin interfered in the combination of β-catenin and TCF/Lef. • Wogonin limited the kinase activity of CDK8. - Abstract: Wogonin, a naturally occurring mono-flavonoid, has been reported to have tumor therapeutic potential and good selectivity both in vitro and in vivo. Herein, we investigated the anti-proliferation effects and associated mechanisms of wogonin in human colorectal cancer in vitro. The flow-cytometric analysis showed that wogonin induced a G1 phase cell cycle arrest in HCT116 cells in a concentration- and time-dependent manner. Meanwhile, the cell cycle-related proteins, such as cyclin A, E, D1, and CDK2, 4 were down-regulated in wogonin-induced G1 cell cycle arrest. Furthermore, we showed that the anti-proliferation and G1 arrest effect of wogonin on HCT116 cells was associated with deregulation of Wnt/β-catenin signaling pathway. Wogonin-treated cells showed decreased intracellular levels of Wnt proteins, and activated degradation complex to phosphorylated and targeted β-catenin for proteasomal degradation. Wogonin inhibited β-catenin-mediated transcription by interfering in the transcriptional activity of TCF/Lef, and repressing the kinase activity of CDK8 which has been considered as an oncogene involving in the development of colorectal cancers. Moreover, CDK8 siRNA-transfected HCT116 cells showed similar results to wogonin treated cells. Thus, our data suggested that wogonin induced anti-proliferation and G1 arrest via Wnt/β-catenin signaling pathway and it can be developed as a therapeutic agent against human colorectal cancer

  20. From Traffic Flow to Economic System

    Science.gov (United States)

    Bando, M.

    The optimal velocity model which is applied to traffic flow phenomena explains a spontaneous formation of traffic congestion. We discuss why the model works well in describing both free-flow and congested flow states in a unified way. The essential ingredient is that our model takes account of a sort of time delay in reacting to a given stimulus. This causes instability of many-body system, and yields a kind of phase transition above a certain critical density. Especially there appears a limit cycle on the phase space along which individual vehicle moves, and they show cyclic behavior. Once that we recognize the mechanism the same idea can be applied to a variety of phenomena which show cyclic behavior observed in many-body systems. As an example of such applications, we investigate business cycles commonly observed in economic system. We further discuss a possible origin of a kind of cyclic behavior observed in climate change.

  1. Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene

    DEFF Research Database (Denmark)

    Højlund, K.; Wojtaszewski, Jørgen; Birk, Jesper Bratz;

    2006-01-01

    AIMS/HYPOTHESIS: Recently we reported the coexistence of postprandial hypoglycaemia and moderate insulin resistance in heterozygous carriers of the Arg1174Gln mutation in the insulin receptor gene (INSR). Controlled studies of in vivo insulin signalling in humans with mutant INSR are unavailable,...

  2. Effect on road traffic injuries of criminalizing road traffic offences: a time-series study

    Directory of Open Access Journals (Sweden)

    Ana M Novoa

    2011-06-01

    Full Text Available OBJECTIVE: To determine the effect of criminalizing some traffic behaviours, after the reform of the Spanish penal code in 2007, on the number of drivers involved in injury collisions and of people injured in traffic collisions in Spain. METHODS: This study followed an interrupted times-series design in which the number of drivers involved in injury collisions and of people injured in traffic collisions in Spain before and after the criminalization of offences were compared. The data on road traffic injuries in 2000-2009 were obtained from the road traffic collision database of the General Traffic Directorate. The dependent variables were stratified by sex, age, injury severity, type of road user, road type and time of collision. Quasi-Poisson regression models were fitted with adjustments for time trend, seasonality, previous interventions and national fuel consumption. FINDINGS: The overall number of male drivers involved in injury collisions dropped (relative risk, RR: 0.93; 95% confidence interval, CI: 0.89-0.97 after the reform of the penal code, but among women no change was observed (RR: 0.99; 95% CI: 0.95-1.03. In addition, 13 891 men (P < 0.01 were prevented from being injured. Larger reductions were observed among young male drivers and among male motorcycle or moped riders than among the drivers of other vehicles. CONCLUSION: The findings suggest that criminalizing certain traffic behaviours can improve road safety by reducing both the number of drivers involved in injury collisions and the number of people injured in such collisions.

  3. ROLE OF PI3K-AKT-mTOR AND Wnt SIGNALING PATHWAYS IN G1-S TRANSITION OF CELL CYCLE IN CANCER CELLS

    Directory of Open Access Journals (Sweden)

    LAKSHMIPATHI eVADLAKONDA

    2013-04-01

    Full Text Available The PI3K–Akt pathway together with one of its downstream targets, the mechanistic target of rapamycin (mTOR is a highly deregulated pathway in cancers. There is a reciprocal relation between the Akt phosphorylation and mTOR complexes. Akt phosphorylated at T308 activates mTORC1 by inhibition of the tuberous sclerosis complex (TSC1/2, where as mTORC2 is recognized as the kinase that phosphorylates Akt at S473. Recent developments in the research on regulatory mechanisms of autophagy places mTORC1 mediated inhibition of autophagy at the central position in activation of proliferation and survival pathways in cells. Autophagy is a negative regulator of Wnt signaling pathway and the downstream effectors of Wnt signaling pathway, cyclin D1 and the c-Myc, are the key players in initiation of cell cycle and regulation of the G1-S transition in cancer cells. Production of reaction oxygen species (ROS, a common feature of a cancer cell metabolism, activates several downstream targets like the transcription factors FoxO, which play key roles in promoting the progression of cell cycle. A model is presented on the role of PI3K -Akt - mTOR and Wnt pathways in regulation of the progression of cell cycle through Go-G1-and S phases.

  4. Cell death, clearance and immunity in the skeletal muscle.

    Science.gov (United States)

    Sciorati, C; Rigamonti, E; Manfredi, A A; Rovere-Querini, P

    2016-06-01

    The skeletal muscle is an immunologically unique tissue. Leukocytes, virtually absent in physiological conditions, are quickly recruited into the tissue upon injury and persist during regeneration. Apoptosis, necrosis and autophagy coexist in the injured/regenerating muscles, including those of patients with neuromuscular disorders, such as inflammatory myopathies, dystrophies, metabolic and mitochondrial myopathies and drug-induced myopathies. Macrophages are able to alter their function in response to microenvironment conditions and as a consequence coordinate changes within the tissue from the early injury throughout regeneration and eventual healing, and regulate the activation and the function of stem cells. Early after injury, classically activated macrophages ('M1') dominate the picture. Alternatively activated M2 macrophages predominate during resolution phases and regulate the termination of the inflammatory responses. The dynamic M1/M2 transition is increasingly felt to be the key to the homeostasis of the muscle. Recognition and clearance of debris originating from damaged myofibers and from dying stem/progenitor cells, stromal cells and leukocytes are fundamental actions of macrophages. Clearance of apoptotic cells and M1/M2 transition are causally connected and represent limiting steps for muscle healing. The accumulation of apoptotic cells, which reflects their defective clearance, has been demonstrated in various tissues to prompt autoimmunity against intracellular autoantigens. In the muscle, in the presence of type I interferon, apoptotic myoblasts indeed cause the production of autoantibodies, lymphocyte infiltration and continuous cycles of muscle injury and regeneration, mimicking human inflammatory myopathies. The clearance of apoptotic cells thus modulates the homeostatic response of the skeletal muscle to injury. Conversely, defects in the process may have deleterious local effects, guiding maladaptive tissue remodeling with collagen and fat

  5. Lactate clearance in cardiorespiratory emergency

    OpenAIRE

    Serena Greco; Giovanna Guiotto; Antonino Maffei; Stefania Martino; Giuseppe Romano; Fernando Schiraldi

    2007-01-01

    Early goal directed therapy has been found to improve prognosis in septic patients, if the therapeutic goal is achieved within the first six hours. The aim of our study is to demonstrate that in patients with acute cardiorespiratory failure, rapid (within 2 hours) lactate clearance can help define patients’ prognosis. 67 consecutive patients, admitted to our 16-bed Emergency Medicine ward for acute cardiorespiratory failure (age 75,9 ± 9,8) (APACHE II score 19,0 ± 4,1), we...

  6. Intelligent Controlling Simulation of Traffic Flow in a Small City Network

    CERN Document Server

    Fouladvand, M E; Sadjadi, Z; Sadjadi, Zeinab

    2005-01-01

    We propose a two dimensional probabilistic cellular automata for the description of traffic flow in a small city network composed of two intersections. The traffic in the network is controlled by a set of traffic lights which can be operated both in fixed-time and a traffic responsive manner. Vehicular dynamics is simulated and the total delay experienced by the traffic is evaluated within specified time intervals. We investigate both decentralized and centralized traffic responsive schemes and in particular discuss the implementation of the {\\it green-wave} strategy. Our investigations prove that the network delay strongly depends on the signalisation strategy. We show that in some traffic conditions, the application of the green-wave scheme may destructively lead to the increment of the global delay.

  7. Emergent traffic jams

    CERN Document Server

    Nagel, K; Nagel, Kai; Paczuski, Maya

    1995-01-01

    We study a single-lane traffic model that is based on human driving behavior. The outflow from a traffic jam self-organizes to a critical state of maximum throughput. Small perturbations of the outflow far downstream create emergent traffic jams with a power law distribution P(t) \\sim t^{-3/2} of lifetimes, t. On varying the vehicle density in a closed system, this critical state separates lamellar and jammed regimes, and exhibits 1/f noise in the power spectrum. Using random walk arguments, in conjunction with a cascade equation, we develop a phenomenological theory that predicts the critical exponents for this transition and explains the self-organizing behavior. These predictions are consistent with all of our numerical results.

  8. Interval Graph Limits

    OpenAIRE

    Diaconis, Persi; Holmes, Susan; Janson, Svante

    2012-01-01

    We work out the graph limit theory for dense interval graphs. The theory developed departs from the usual description of a graph limit as a symmetric function $W(x,y)$ on the unit square, with $x$ and $y$ uniform on the interval $(0,1)$. Instead, we fix a $W$ and change the underlying distribution of the coordinates $x$ and $y$. We find choices such that our limits are continuous. Connections to random interval graphs are given, including some examples. We also show a continuity result for th...

  9. Bootstrap confidence intervals

    OpenAIRE

    Thomas J. DiCiccio; Efron, Bradley

    1996-01-01

    This article surveys bootstrap methods for producing good approximate confidence intervals. The goal is to improve by an order of magnitude upon the accuracy of the standard intervals $\\hat{\\theta} \\pm z^{(\\alpha)} \\hat{\\sigma}$, in a way that allows routine application even to very complicated problems. Both theory and examples are used to show how this is done. The first seven sections provide a heuristic overview of four bootstrap confidence interval procedures: $BC_a$, bootstrap-t , ABC a...

  10. Traffic Engineering in Metro Ethernet

    Directory of Open Access Journals (Sweden)

    Padmaraj Nair

    2010-05-01

    Full Text Available Traffic engineering is one of the major issues that has to be addressed in Metro Ethernet networks for quality of service and efficient resource utilization. This paper aims at understanding the relevant issues and outlines novel algorithms for multipoint traffic engineering in Metro Ethernet. We present an algorithmic solution for traffic engineering in Metro Ethernet using optimal multiple spanning trees. This iterative approach distributes traffic across the network uniformly without overloading network resources. We also introduce a new traffic specification model for Metro Ethernet, which is a hybrid of two widely used traffic specification models, the pipe and hose models.

  11. Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts

    Science.gov (United States)

    Shimura, Tsutomu; Sasatani, Megumi; Kamiya, Kenji; Kawai, Hidehiko; Inaba, Yohei; Kunugita, Naoki

    2016-01-01

    Here we investigated the cellular response of normal human fibroblasts to repeated exposure to low-dose radiation. In contrast to acute single radiation, low-dose fractionated radiation (FR) with 0.01 Gy/fraction or 0.05 Gy/fraction for 31 days increased in mitochondrial mass, decreased cellular levels of the antioxidant glutathione and caused persistent accumulation of mitochondrial reactive oxygen species (ROS). Excess ROS promoted oxidative inactivation of protein phosphatase PP2A which in turn led to disruption of normal negative feed-back control of AKT/cyclin D1 signaling in cells treated with long-term FR. The resulting abnormal nuclear accumulation of cyclin D1 causes growth retardation, cellular senescence and genome instability in low-dose irradiated cells. Thus, loss of redox control and subsequently elevated levels of ROS perturb signal transduction as a result of oxidative stress. Our study highlights a specific role of mitochondrial ROS in perturbation of AKT/cyclin D1 cell cycle signaling after low-dose long-term FR. The antioxidants N-acetyl-L-cysteine, TEMPO and mitochondrial-targeted antioxidant Mito-TEMPO provided protection against the harmful cell cycle perturbations induced by low-dose long-term FR. PMID:26657292

  12. Target-induced formation of gold amalgamation on DNA-based sensing platform for electrochemical monitoring of mercury ion coupling with cycling signal amplification strategy.

    Science.gov (United States)

    Chen, Jinfeng; Tang, Juan; Zhou, Jun; Zhang, Lan; Chen, Guonan; Tang, Dianping

    2014-01-31

    Heavy metal ion pollution poses severe risks in human health and environmental pollutant, because of the likelihood of bioaccumulation and toxicity. Driven by the requirement to monitor trace-level mercury ion (Hg(2+)), herein we construct a new DNA-based sensor for sensitive electrochemical monitoring of Hg(2+) by coupling target-induced formation of gold amalgamation on DNA-based sensing platform with gold amalgamation-catalyzed cycling signal amplification strategy. The sensor was simply prepared by covalent conjugation of aminated poly-T(25) oligonucleotide onto the glassy carbon electrode by typical carbodiimide coupling. Upon introduction of target analyte, Hg(2+) ion was intercalated into the DNA polyion complex membrane based on T-Hg(2+)-T coordination chemistry. The chelated Hg(2+) ion could induce the formation of gold amalgamation, which could catalyze the p-nitrophenol with the aid of NaBH4 and Ru(NH3)6(3+) for cycling signal amplification. Experimental results indicated that the electronic signal of our system increased with the increasing Hg(2+) level in the sample, and has a detection limit of 0.02nM with a dynamic range of up to 1000nM Hg(2+). The strategy afforded exquisite selectivity for Hg(2+) against other environmentally related metal ions. In addition, the methodology was evaluated for the analysis of Hg(2+) in spiked tap-water samples, and the recovery was 87.9-113.8%. PMID:24439499

  13. Design of small interval signal acquisition system for low-energy X-ray industrial CT%低能X射线工业CT小间隔信号采集系统

    Institute of Scientific and Technical Information of China (English)

    周钦; 高富强; 陈聃青; 陈晟飞

    2013-01-01

    In order to solve the traditional detectors' shortcomings of low speed and weak precision, to detect small sophisticated devices, and meet the demand of reconstructed images with high spatial resolution in low-energy X-ray microfocus CT systems, a small interval signal acquisition system is proposed. The system takes X-CARD 0. 2-256G as the detector, which is highly integrated with fast scanning speed and only 0. 2 mm pixel size, Cyclone EP1C3T as the core logic control module, and LXT972A as the Ethernet chip. The whole hardware and logic designations are described clearly in terms of the performance of reliable, stable and high efficiency. Then the dynamic range of the system is tested. Experimental results show that the proposed system has a dynamic range larger than 4000, can collect and transport the signal quickly and accurately, and can satisfy the requirements of ICT transmission sufficiently.%为克服探测器阵列获取速度慢、重建图像精度低的缺点,并能在低能X射线的小焦点/微焦点CT系统中完成对小型精密复杂器件的检测,研究了低能X射线工业CT的小间隔信号采集系统.系统选取DT公司0.2 mm像素尺寸、高集成度、扫描速度快的X-CARD 0.2-256G为探测器,Altera公司的Cyclone EP1C3T为主控芯片,Intel公司的LXT972A为以太网控制芯片.从数据传输的可靠、稳定、高效率角度出发,用模块化的方法给出了系统的硬件设计,用有限状态机技术完成了系统的逻辑单元设计,并对系统的动态范围进行了测试.测试实验结果表明,系统的动态范围大于4000,能够检测精密器件、准确迅速地完成信号的采集传输,满足实际工业CT对信号采集的要求.

  14. RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS

    Directory of Open Access Journals (Sweden)

    Z. IQBAL, I. JAVED, B. ASLAM, F. MUHAMMAD AND I. U. JAN

    2007-10-01

    Full Text Available The renal clearance and urinary excretion of ciprofloxacin were investigated in eight healthy female goats. In each animal, ciprofloxacin was administered intramuscularly at the rate of 5 mg/kg body weight. Following drug administration, blood and urine samples were collected at different time intervals and analyzed for ciprofloxacin and creatinine. High performance liquid chromatography (HPLC was used to determine the drug concentration in the plasma and urine. The value of diuresis after single administration of ciprofloxacin was 0.073 ± 0.014 ml/min/kg. Mean (± SE values for renal clearance of creatinine and ciprofloxacin were 1.870 ± 0.385 and 0.982 ± 0.166 ml/min/kg, respectively. The ratio between the renal clearance of ciprofloxacin and that of creatinine remained less than one, which was indicative of back diffusion. The mean (± SE value for the cumulative percent of ciprofloxacin dose excreted at 10 hours following its intramuscular administration was 13.03 ± 2.07. Based on these results, it was evident that besides glomerular filtration, renal handling of drug involved back diffusion also. It was concluded that in local goats glomerular filtration rate (GFR was lower than that reported for their foreign counterparts.

  15. The Clearance of Cyclosporine by Hemodialysis

    OpenAIRE

    Venkataramanan, Raman; Ptachcinski, Richard J.; Burckart, Gilbert J.; YANG, SHIN L.; Starzl, Thomas E.; VAN THEIL, DAVID H.

    1984-01-01

    The pharmacokinetics of cyclosporine were studied in five liver transplant patients when they were on and off hemodialysis. There was no significant difference in the blood clearance of cyclosporine between these two periods. Less than 1 per cent of the dose of cyclosporine was recovered in the dialysate. The mean dialysis clearance was less than 1 ml/min. This represents less than 1 per cent of the total blood clearance of cyclosporine. Dosage alterations of cyclosporine during or after hemo...

  16. Revolute joints with clearance in multibody systems

    OpenAIRE

    Flores, Paulo; Ambrósio, Jorge

    2004-01-01

    A computational methodology for dynamic analysis of multibody mechanical systems with joint clearance is presented in this work. Clearances always exist in real joints in order to ensure the correct relative motion between the connected bodies being the gap associated to them a result of machining tolerance, wear, and local deformations. Clearance at different joints is the source for impact forces, resulting in wear and tear of the joints, and consequently the degradation of the system perfo...

  17. Traffic Light Detection

    DEFF Research Database (Denmark)

    Philipsen, Mark Philip; Jensen, Morten Bornø; Møgelmose, Andreas;

    2015-01-01

    Traffic light recognition (TLR) is an integral part of any intelligent vehicle, which must function in the existing infrastructure. Pedestrian and sign detection have recently seen great improvements due to the introduction of learning based detectors using integral channel features. A similar push...... database is collected based on footage from US roads. The database consists of both test and training data, totaling 46,418 frames and 112,971 annotated traffic lights, captured in continuous sequences under a varying light and weather conditions. The learning based detector achieves an AUC of 0.4 and 0...

  18. The Role of Intrinsic Flexibility in Signal Transduction Mediated by the Cell Cycle Regulator, p27Kip1

    Energy Technology Data Exchange (ETDEWEB)

    Galea, Charles A. [St. Jude Children' s Research Hospital; Nourse, Amanda [St. Jude Children' s Research Hospital; Wang, Yuefeng [St. Jude Children' s Research Hospital; Sivakolundu, Sivashankar G. [St. Jude Children' s Research Hospital; Heller, William T [ORNL; Kriwacki, Richard W [University of Tennessee (UT) Health Science Center, Memphis

    2008-02-01

    p27{sup Kip1} (p27), which controls eukaryotic cell division through interactions with cyclin-dependent kinases (Cdks), integrates and transduces promitogenic signals from various nonreceptor tyrosine kinases by orchestrating its own phosphorylation, ubiquitination and degradation. Intrinsic flexibility allows p27 to act as a 'conduit' for sequential signaling mediated by tyrosine and threonine phosphorylation and ubiquitination. While the structural features of the Cdk/cyclin-binding domain of p27 are understood, how the C-terminal regulatory domain coordinates multistep signaling leading to p27 degradation is poorly understood. We show that the 100-residue p27 C-terminal domain is extended and flexible when p27 is bound to Cdk2/cyclin A. We propose that the intrinsic flexibility of p27 provides a molecular basis for the sequential signal transduction conduit that regulates p27 degradation and cell division. Other intrinsically unstructured proteins possessing multiple sites of posttranslational modification may participate in similar signaling conduits.

  19. Integrated Traffic Flow Management Decision Making

    Science.gov (United States)

    Grabbe, Shon R.; Sridhar, Banavar; Mukherjee, Avijit

    2009-01-01

    A generalized approach is proposed to support integrated traffic flow management decision making studies at both the U.S. national and regional levels. It can consider tradeoffs between alternative optimization and heuristic based models, strategic versus tactical flight controls, and system versus fleet preferences. Preliminary testing was accomplished by implementing thirteen unique traffic flow management models, which included all of the key components of the system and conducting 85, six-hour fast-time simulation experiments. These experiments considered variations in the strategic planning look-ahead times, the replanning intervals, and the types of traffic flow management control strategies. Initial testing indicates that longer strategic planning look-ahead times and re-planning intervals result in steadily decreasing levels of sector congestion for a fixed delay level. This applies when accurate estimates of the air traffic demand, airport capacities and airspace capacities are available. In general, the distribution of the delays amongst the users was found to be most equitable when scheduling flights using a heuristic scheduling algorithm, such as ration-by-distance. On the other hand, equity was the worst when using scheduling algorithms that took into account the number of seats aboard each flight. Though the scheduling algorithms were effective at alleviating sector congestion, the tactical rerouting algorithm was the primary control for avoiding en route weather hazards. Finally, the modeled levels of sector congestion, the number of weather incursions, and the total system delays, were found to be in fair agreement with the values that were operationally observed on both good and bad weather days.

  20. Mucociliary clearance in early simple chronic bronchitis

    International Nuclear Information System (INIS)

    Tracheobronchial mucociliary clearance was measured in 37 patients with early simple chronic bronchitis. A non-invasive radio-aerosol technique with inhalation of 99Tcm labelled 5-μm polystyrene particles followed by assessment of radio-nuclide distribution by posterior gamma-camera scans was employed. The mucociliary clearance of the bronchitics was significantly slower than clearance of a non-smoker control group. An interim analysis of the effect of treatment with a surfactant stimulating drug, ambroxol, suggested a dosage-dependent tendency to a faster mucociliary clearance than seen in placebo-treated bronchitics. (author)

  1. Algorithmic testing for QT interval measurements

    OpenAIRE

    Bortolan, Giovanni

    2006-01-01

    The PTB diagnostic ECG database has been used for testing the fully automated program for the identification and measurement of QT interval. The database consists of 549 ECG recordings of 294 subjects. The testing algorithm uses the Padova program, which identifies all QRS complexes analyzing a global spatial velocity and the ECG signal. Different strategies for the choice of the optimal QT interval have been compared, and the optimization of T end in the single leads was performed using the ...

  2. The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle

    Directory of Open Access Journals (Sweden)

    Alessandra Cambi

    2013-03-01

    Full Text Available Many processes regulating immune responses are initiated by G-protein coupled receptors (GPCRs and report biochemical changes in the microenvironment. Dendritic cells (DCs are the most potent antigen-presenting cells and crucial for the regulation of innate and adaptive immune responses. The lipid mediator Prostaglandin E2 (PGE2 via four GPCR subtypes (EP1-4 critically regulates DC generation, maturation and migration. The role of PGE2 signaling in DC biology was unraveled by the characterization of EP receptor subtype expression in DC progenitor cells and DCs, the identification of the signaling pathways initiated by these GPCR subtypes and the classification of DC responses to PGE2 at different stages of differentiation. Here, we review the advances in PGE2 signaling in DCs and describe the efforts still to be made to understand the spatio-temporal fine-tuning of PGE2 responses by DCs.

  3. AB109. Downregulation of tNASP inhibits proliferation through regulating cell cycle-related proteins and inactive ERK/MAPK signal pathway in renal cell carcinoma cells

    Science.gov (United States)

    Fang, Jianzheng; Wang, Hainan; Cheng, Gong; Wang, Shangqian; Deng, Yunfei; Song, Zhen; Xu, Aiming; Liu, Bianjiang; Wang, Zengjun

    2016-01-01

    Objective Nuclear auto-antigenic sperm protein (NASP), initially described as a highly auto-immunogenic testis and sperm-specific protein, is a histone chaperone that is proved to present in all dividing cells. NASP has two splice variants: testicular NASP (tNASP) and somatic form of NASP (sNASP). Only cancer, germ, transformed, and embryonic cells have a high level of expression of the tNASP. Up to now, little has been known about tNASP in renal cell carcinoma (RCC). In the present study, the molecular mechanism of tNASP in RCC was explored. Methods The expression level of tNASP in 16 paired human RCC specimens was determined. Downregulation of tNASP by small interfering RNA (siRNA) was transfected in RCC cell lines. The effect of downregulation of tNASP by siRNA on cell colony formation and proliferation was examined by colony formation assay and CCK-8 assay, cell cycle was analyzed by flow cytometry, and the expression of cyclin D1 and P21 were detected by Western blotting. ERK/MAPK signaling was also analyzed. Results tNASP has a relative high expression level in human RCC tissues. Via upregulation of P21 and downregulation of cyclinD1, silence of tNASP can inhibit cell proliferation, which induces cell cycle arrest. Furthermore, ERK signaling pathway is confirmed to mediate the regulation of cell cycle-related proteins caused by silence of tNASP. Conclusions Our research demonstrates that knockdown of tNASP effectively inhibits the proliferation and causes G1 phase arrest through ERK/MAPK signal pathway.

  4. Does the time interval between antimüllerian hormone serum sampling and initiation of ovarian stimulation affect its predictive ability in in vitro fertilization-intracytoplasmic sperm injection cycles with a gonadotropin-releasing hormone antagonist?

    DEFF Research Database (Denmark)

    Polyzos, Nikolaos P; Nelson, Scott M; Stoop, Dominic;

    2013-01-01

    To investigate whether the time interval between serum antimüllerian hormone (AMH) sampling and initiation of ovarian stimulation for in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) may affect the predictive ability of the marker for low and excessive ovarian response....

  5. Traffic Light Detection

    DEFF Research Database (Denmark)

    Philipsen, Mark Philip; Jensen, Morten Bornø; Møgelmose, Andreas; Moeslund, Thomas B.; Trivedi, Mohan M.

    database is collected based on footage from US roads. The database consists of both test and training data, totaling 46,418 frames and 112,971 annotated traffic lights, captured in continuous sequences under a varying light and weather conditions. The learning based detector achieves an AUC of 0.4 and 0...

  6. A Language and Toolset for the Synthesis and Efficient Simulation of Clock-Cycle-True Signal-Processing Algorithms

    NARCIS (Netherlands)

    Hofstra, Klaas L.; Gerez, Sabih H.; Kampen, van David

    2005-01-01

    Optimal simulation speed and synthesizability are contradictory requirements for a hardware description language. This paper presents a language and toolset that enables both synthesis and fast simulation of fixed-point signal processing algorithms at the register-transfer level using a single syste

  7. Yellow and All-Red Intervals: How to Improve Safety and Reduce Delay?

    Directory of Open Access Journals (Sweden)

    Faisal Awadallah

    2013-06-01

    Full Text Available Yellow and all-red intervals are intended as a margin of safety. The duration of change intervals needed for safe stopping or crossing of vehicles is not the same for all traffic conditions and patterns. Thus some traffic patterns may not need the full designed intervals’ durations as a safety margin; while at other times, they are not sufficient due mainly to drivers trying to avoid to stop at red lights. The challenge for traffic engineers is to minimize the intersection delay and at the same time maximize intersection safety. A methodology for providing variable length yellow and all-red intervals, based on traffic responsive sensors and logical commands, is outlined. The methodology stresses that safety is improved at some cases over the designed fixed yellow and all-red intervals, but never compromised lower than the default fixed yellow and all-red intervals. In addition, delay is reduced for various traffic patterns. Adhering to traffic agencies standards and regulations is addressed, not only to outline the practical limitations, but also to introduce discussion for potential positive changes.

  8. Traffic Engineering in Metro Ethernet

    OpenAIRE

    Padmaraj Nair; Suku Nair; Girish Chiruvolu

    2010-01-01

    Traffic engineering is one of the major issues that has to be addressed in Metro Ethernet networks for quality of service and efficient resource utilization. This paper aims at understanding the relevant issues and outlines novel algorithms for multipoint traffic engineering in Metro Ethernet. We present an algorithmic solution for traffic engineering in Metro Ethernet using optimal multiple spanning trees. This iterative approach distributes traffic across the network uniformly without overl...

  9. Traffic flow modeling: a Genealogy

    OpenAIRE

    Van Wageningen-Kessels, F.L.M.; Hoogendoorn, S.P.; Vuik, C.; Lint, van J. W. C.

    2014-01-01

    80 years ago, Bruce Greenshields presented the first traffic flow model at the Annual Meeting of the Highway Research Board. Since then, many models and simulation tools have been developed. We show a model tree with four families of traffic flow models, all descending from Greenshields' model. The tree shows the historical development of traffic flow modeling and the relations between models. Based on the tree we discuss the main trends and future developments in traffic flow modeling and si...

  10. Virtualized Traffic at Metropolitan Scales

    OpenAIRE

    Wilkie, David; Sewall, Jason; Li, Weizi; Lin, Ming C.

    2015-01-01

    Few phenomena are more ubiquitous than traffic in urban scenes, and few are more significant economically, socially, or environmentally. Many virtual-reality applications and systems, including virtual globes and immersive multi-player worlds that are often set in a large-scale modern or futuristic setting, feature traffic systems. Virtual-reality models can also aid in addressing the challenges of real-world traffic – the ever-present gridlock and congestion in cities worldwide: traffic engi...

  11. Road Traffic Accidents in Kazakhstan

    OpenAIRE

    Alma Aubakirova; Alibek Kossumov; Nurbek Igissinov

    2013-01-01

    Background: The article provides the analysis of death rates in road traffic accidents in Kazakhstan from 2004 to 2010 and explores the use of sanitary aviation. Methods: Data of fatalities caused by road traffic accidents were collected and analysed. Descriptive and analytical methods of epidemiology and biomedical statistics were applied. Results: Totaly 27,003 people died as a result of road traffic accidents in this period. The death rate for the total population due to road traffic accid...

  12. Coordination of traffic lights evaluation

    OpenAIRE

    Ordeig Vila, Enric

    2012-01-01

    This case study consists in the evaluation of the Kaunas city traffic speed taking into consideration that traffic lights were coordinated. Kaunas suffers from high traffic intensity and, as a consequence, traffic jams often, and happens mainly because the city can only be crossed by the center. Lithuania, as the rest of Europe experienced a big growth, from 1995 to 2005 coinciding with the crisis, that is to say that number of cars increased to highest levels as well as the ...

  13. Automated Traffic Enforcement in France

    OpenAIRE

    BRIQUET, Philippe; CANEL, A

    2002-01-01

    One of the goals of traffic safety in cities and between cities is to increase compliance with Traffic Regulations. For this purpose, the French Ministry of Transportation decided to set up an automated traffic enforcement program. This program currently focuses on several types of violations : speeding, spacing between vehicles, and traffic light and railway crossing. This article presents the main goals of the program and the expected challenges and characteristics of operations that have b...

  14. Automated Conflict Resolution For Air Traffic Control

    Science.gov (United States)

    Erzberger, Heinz

    2005-01-01

    The ability to detect and resolve conflicts automatically is considered to be an essential requirement for the next generation air traffic control system. While systems for automated conflict detection have been used operationally by controllers for more than 20 years, automated resolution systems have so far not reached the level of maturity required for operational deployment. Analytical models and algorithms for automated resolution have been traffic conditions to demonstrate that they can handle the complete spectrum of conflict situations encountered in actual operations. The resolution algorithm described in this paper was formulated to meet the performance requirements of the Automated Airspace Concept (AAC). The AAC, which was described in a recent paper [1], is a candidate for the next generation air traffic control system. The AAC's performance objectives are to increase safety and airspace capacity and to accommodate user preferences in flight operations to the greatest extent possible. In the AAC, resolution trajectories are generated by an automation system on the ground and sent to the aircraft autonomously via data link .The algorithm generating the trajectories must take into account the performance characteristics of the aircraft, the route structure of the airway system, and be capable of resolving all types of conflicts for properly equipped aircraft without requiring supervision and approval by a controller. Furthermore, the resolution trajectories should be compatible with the clearances, vectors and flight plan amendments that controllers customarily issue to pilots in resolving conflicts. The algorithm described herein, although formulated specifically to meet the needs of the AAC, provides a generic engine for resolving conflicts. Thus, it can be incorporated into any operational concept that requires a method for automated resolution, including concepts for autonomous air to air resolution.

  15. HIGH LEVEL MODELLING OF REAL TIME TRAFFIC LIGHT CONTROLLER

    Directory of Open Access Journals (Sweden)

    ADITYA MANDLOI

    2012-12-01

    Full Text Available The objective of this paper is to design and implement traffic control system. The system developed is able to sense the presence of vehicles within certain range by setting the appropriate duration for the traffic signals to react accordingly. By employing logical functions to calculate the appropriate timing for the signals toilluminate, the system can help to solve the problem of traffic congestion. The use of FPGAs (Field Programmable Gate Arrays is an interesting new phenomenon in VLSI development. FPGAs offer all of thefeatures needed to implement most complex designs. Hardware simulation tests were successfully performed on the algorithm implemented into a FPGA (Field Programmable Gate Arrays. The main object of the paper is to design a Real Time Traffic Light Controller (RTTLC using VHDL and implement the RTTLC in XILINX SPARTAN - 3 FPGA.

  16. Development of a Novel System to Measure a Clearance of a Passenger Platform

    Science.gov (United States)

    Shimizu, M.; Oizumi, J.; Matsuoka, R.; Takeda, H.; Okukura, H.; Ooya, A.; Koike, A.

    2016-06-01

    Clearances of a passenger platform at a railway station should be appropriately maintained for safety of both trains and passengers. In most Japanese railways clearances between a platform and a train car is measured precisely once or twice a year. Because current measurement systems operate on a track, the closure of the track is unavoidable. Since the procedure of the closure of a track is time-consuming and bothersome, we decided to develop a new system to measure clearances without the closure of a track. A new system is required to work on a platform and the required measurement accuracy is less than several millimetres. We have adopted a 3D laser scanner and stop-and-go operation for a new system. The current systems on a track measure clearances continuously at walking speed, while our system on a platform measures clearances at approximately ten metres intervals. The scanner controlled by a PC acquires a set of point data at each measuring station. Edge points of the platform, top and side points of two rails are detected from the acquired point data. Finally clearances of the platform are calculated by using the detected feature points of the platform and the rails. The results of an experiment using a prototype of our system show that the measurement accuracy by our system would be satisfactory, but our system would take more time than the current systems. Since our system requires no closure of a track, we conclude that our system would be convenient and effective.

  17. Traffic sign detection and analysis

    DEFF Research Database (Denmark)

    Møgelmose, Andreas; Trivedi, Mohan M.; Moeslund, Thomas B.

    Traffic sign recognition (TSR) is a research field that has seen much activity in the recent decade. This paper introduces the problem and presents 4 recent papers on traffic sign detection and 4 recent papers on traffic sign classification. It attempts to extract recent trends in the field and...

  18. CATS-based Air Traffic Controller Agents

    Science.gov (United States)

    Callantine, Todd J.

    2002-01-01

    This report describes intelligent agents that function as air traffic controllers. Each agent controls traffic in a single sector in real time; agents controlling traffic in adjoining sectors can coordinate to manage an arrival flow across a given meter fix. The purpose of this research is threefold. First, it seeks to study the design of agents for controlling complex systems. In particular, it investigates agent planning and reactive control functionality in a dynamic environment in which a variety perceptual and decision making skills play a central role. It examines how heuristic rules can be applied to model planning and decision making skills, rather than attempting to apply optimization methods. Thus, the research attempts to develop intelligent agents that provide an approximation of human air traffic controller behavior that, while not based on an explicit cognitive model, does produce task performance consistent with the way human air traffic controllers operate. Second, this research sought to extend previous research on using the Crew Activity Tracking System (CATS) as the basis for intelligent agents. The agents use a high-level model of air traffic controller activities to structure the control task. To execute an activity in the CATS model, according to the current task context, the agents reference a 'skill library' and 'control rules' that in turn execute the pattern recognition, planning, and decision-making required to perform the activity. Applying the skills enables the agents to modify their representation of the current control situation (i.e., the 'flick' or 'picture'). The updated representation supports the next activity in a cycle of action that, taken as a whole, simulates air traffic controller behavior. A third, practical motivation for this research is to use intelligent agents to support evaluation of new air traffic control (ATC) methods to support new Air Traffic Management (ATM) concepts. Current approaches that use large, human

  19. Productive life cycle of adeno-associated virus serotype 2 in the complete absence of a conventional polyadenylation signal.

    Science.gov (United States)

    Wang, Lina; Yin, Zifei; Wang, Yuan; Lu, Yuan; Zhang, Daniel; Srivastava, Arun; Ling, Changquan; Aslanidi, George V; Ling, Chen

    2015-09-01

    We showed that WT adeno-associated virus serotype 2 (AAV2) genome devoid of a conventional polyadenylation [poly(A)] signal underwent complete genome replication, encapsidation and progeny virion production in the presence of adenovirus. The infectivity of the progeny virion was also retained. Using recombinant AAV2 vectors devoid of a human growth hormone poly(A) signal, we also demonstrated that a subset of mRNA transcripts contained the inverted terminal repeat (ITR) sequence at the 3' end, which we designated ITR in RNA (ITRR). Furthermore, AAV replication (Rep) proteins were able to interact with the ITRR. Taken together, our studies suggest a new function of the AAV2 ITR as an RNA element to mediate transgene expression from poly(A)-deleted mRNA. PMID:26297494

  20. Traffic Light Geography: A Fifth Grade Community Project.

    Science.gov (United States)

    Zirschky, E. Dwight

    1989-01-01

    Describes a community study project that uses history and the five fundamental themes of geography as a framework. The project involves organizing committees to study the need for a traffic signal in a small town. By studying various dimensions of the issue, the committees are able to demonstrate the need for a signal. (KO)