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Sample records for class 1a dihydroorotate

  1. Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis

    DEFF Research Database (Denmark)

    Wolfe, Abigail E; Thymark, Majbritt; Gattis, Samuel G;

    2007-01-01

    Dihydroorotate dehydrogenases (DHODs) catalyze the oxidation of dihydroorotate to orotate in the only redox reaction in pyrimidine biosynthesis. The pyrimidine binding sites are very similar in all structurally characterized DHODs, suggesting that the prospects for identifying a class-specific in......Dihydroorotate dehydrogenases (DHODs) catalyze the oxidation of dihydroorotate to orotate in the only redox reaction in pyrimidine biosynthesis. The pyrimidine binding sites are very similar in all structurally characterized DHODs, suggesting that the prospects for identifying a class......-specific inhibitor directed against this site are poor. Nonetheless, two compounds that bind specifically to the Class 1A DHOD from Lactococcus lactis, 3,4-dihydroxybenzoate (3,4-diOHB) and 3,5-dihydroxybenzoate (3,5-diOHB), have been identified [Palfey et al. (2001) J. Med. Chem. 44, 2861-2864]. The mechanism...... of inhibitor binding to the Class 1A DHOD from L. lactis has now been studied in detail and is reported here. Titrations showed that 3,4-diOHB binds more tightly at higher pH, whereas the opposite is true for 3,5-diOHB. Isothermal titration calorimetry and absorbance spectroscopy showed that 3,4-diOHB ionizes...

  2. Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis

    DEFF Research Database (Denmark)

    Fagan, Rebecca L; Jensen, Kaj Frank; Björnberg, Olof;

    2007-01-01

    is concerted or stepwise was addressed for the class 1A enzyme from Lactococcus lactis by determining kinetic isotope effects (KIEs) on flavin reduction in anaerobic stopped-flow experiments. Isotope effects were determined at two pH values. At pH 7.0, KIEs were approximately 2-fold for DHO labeled singly...... mutants was extremely slow compared to that of the wild type; the rate of reduction increased with pH, showing no sign of a plateau. Interestingly, double-deuterium isotope effects on the Cys130Ser mutant also showed a concerted mechanism for flavin reduction....

  3. E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases

    DEFF Research Database (Denmark)

    Nørager, Sofie; Jensen, Kaj Frank; Björnberg, Olof

    2002-01-01

    . The structure of class 2 E. coli DHOD, determined by MAD phasing, showed that the N-terminal extension forms a separate domain. The catalytic serine residue has an environment differing from the equivalent cysteine in class 1 DHODs. Significant differences between the two classes of DHODs were identified...... by comparison of the E. coli DHOD with the other known DHOD structures, and differences with the class 2 human DHOD explain the variation in their inhibitors....

  4. Insights into the mechanism of oxidation of dihydroorotate to orotate catalysed by human class 2 dihydroorotate dehydrogenase: a QM/MM free energy study.

    Science.gov (United States)

    Alves, Cláudio Nahum; Silva, José Rogério A; Roitberg, Adrian E

    2015-07-21

    The dihydroorotate dehydrogenase (DHOD) enzyme catalyzes the unique redox reaction in the de novo pyrimidine biosynthesis pathway. In this reaction, the oxidation of dihydroorotate (DHO) to orotate (OA) and reduction of the flavin mononucleotide (FMN) cofactor is catalysed by DHOD. The class 2 DHOD, to which the human enzyme belongs, was experimentally shown to follow a stepwise mechanism but the data did not allow the determination of the order of bond-breaking in a stepwise oxidation of DHO. The goal of this study is to understand the reaction mechanism at the molecular level of class 2 DHOD, which may aid in the design of inhibitors that selectively impact the activity of only certain members of the enzyme family. In this paper, the catalytic mechanism of oxidation of DHO to OA in human DHOD was studied using a hybrid Quantum Mechanical/Molecular Mechanical (QM/MM) approach and Molecular Dynamics (MD) simulations. The free energy barriers calculated reveal that the mechanism in human DHOD occurs via a stepwise reaction pathway. In the first step, a proton is abstracted from the C5 of DHO to the deprotonated Ser215 side chain. Whereas, in the second step, the transfer of the hydride or hydride equivalent from the C6 of DHO to the N5 of FMN, where free energy barrier calculated by the DFT/MM level is 10.84 kcal mol(-1). Finally, a residual decomposition analysis was carried out in order to elucidate the influence of the catalytic region residues during DHO oxidation.

  5. Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Xiaoyi; Gujjar, Ramesh; El Mazouni, Farah; Kaminsky, Werner; Malmquist, Nicholas A.; Goldsmith, Elizabeth J.; Rathod, Pradipsinh K.; Phillips, Margaret A.; (UWASH); (UTSMC)

    2010-01-20

    Malaria remains a major global health burden and current drug therapies are compromised by resistance. Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) was validated as a new drug target through the identification of potent and selective triazolopyrimidine-based DHODH inhibitors with anti-malarial activity in vivo. Here we report x-ray structure determination of PfDHODH bound to three inhibitors from this series, representing the first of the enzyme bound to malaria specific inhibitors. We demonstrate that conformational flexibility results in an unexpected binding mode identifying a new hydrophobic pocket on the enzyme. Importantly this plasticity allows PfDHODH to bind inhibitors from different chemical classes and to accommodate inhibitor modifications during lead optimization, increasing the value of PfDHODH as a drug target. A second discovery, based on small molecule crystallography, is that the triazolopyrimidines populate a resonance form that promotes charge separation. These intrinsic dipoles allow formation of energetically favorable H-bond interactions with the enzyme. The importance of delocalization to binding affinity was supported by site-directed mutagenesis and the demonstration that triazolopyrimidine analogs that lack this intrinsic dipole are inactive. Finally, the PfDHODH-triazolopyrimidine bound structures provide considerable new insight into species-selective inhibitor binding in this enzyme family. Together, these studies will directly impact efforts to exploit PfDHODH for the development of anti-malarial chemotherapy.

  6. Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.

    Science.gov (United States)

    Hey-Mogensen, Martin; Goncalves, Renata L S; Orr, Adam L; Brand, Martin D

    2014-07-01

    Dehydrogenases that use ubiquinone as an electron acceptor, including complex I of the respiratory chain, complex II, and glycerol-3-phosphate dehydrogenase, are known to be direct generators of superoxide and/or H2O2. Dihydroorotate dehydrogenase oxidizes dihydroorotate to orotate and reduces ubiquinone to ubiquinol during pyrimidine metabolism, but it is unclear whether it produces superoxide and/or H2O2 directly or does so only indirectly from other sites in the electron transport chain. Using mitochondria isolated from rat skeletal muscle we establish that dihydroorotate oxidation leads to superoxide/H2O2 production at a fairly high rate of about 300pmol H2O2·min(-1)·mg protein(-1) when oxidation of ubiquinol is prevented and complex II is uninhibited. This H2O2 production is abolished by brequinar or leflunomide, known inhibitors of dihydroorotate dehydrogenase. Eighty percent of this rate is indirect, originating from site IIF of complex II, because it can be prevented by malonate or atpenin A5, inhibitors of complex II. In the presence of inhibitors of all known sites of superoxide/H2O2 production (rotenone to inhibit sites in complex I (site IQ and, indirectly, site IF), myxothiazol to inhibit site IIIQo in complex III, and malonate plus atpenin A5 to inhibit site IIF in complex II), dihydroorotate dehydrogenase generates superoxide/H2O2, at a small but significant rate (23pmol H2O2·min(-1)·mg protein(-1)), from the ubiquinone-binding site. We conclude that dihydroorotate dehydrogenase can generate superoxide and/or H2O2 directly at low rates and is also capable of indirect production at higher rates from other sites through its ability to reduce the ubiquinone pool.

  7. Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans

    DEFF Research Database (Denmark)

    Zameitat, E.; Gojkovic, Zoran; Knecht, Wolfgang

    2006-01-01

    Candida albicans is the most prevalent yeast pathogen in humans, and recently it has become increasingly resistant to the current antifungal agents. In this study we investigated C. albicans dihydroorotate dehydrogenase (DHODH, EC 1.3.99.11), which catalyzes the fourth step of de novo pyrimidine...

  8. Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate

    Energy Technology Data Exchange (ETDEWEB)

    Inaoka, Daniel Ken; Takashima, Eizo; Osanai, Arihiro; Shimizu, Hironari [Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Nara, Takeshi; Aoki, Takashi [Department of Parasitology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Harada, Shigeharu [Department of Applied Biology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585 (Japan); Kita, Kiyoshi, E-mail: kitak@m.u-tokyo.ac.jp [Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2005-10-01

    The Trypanosoma cruzi dihydroorotate dehydrogenase, a key enzyme in pyrimidine de novo biosynthesis and redox homeostasis, was crystallized in complex with its first reaction product, orotate. Dihydroorotate dehydrogenase (DHOD) catalyzes the oxidation of dihydroorotate to orotate, the fourth step and the only redox reaction in the de novo biosynthesis of pyrimidine. DHOD from Trypanosoma cruzi (TcDHOD) has been expressed as a recombinant protein in Escherichia coli and purified to homogeneity. Crystals of the TcDHOD–orotate complex were grown at 277 K by the sitting-drop vapour-diffusion technique using polyethylene glycol 3350 as a precipitant. The crystals diffract to better than 1.8 Å resolution using synchrotron radiation (λ = 0.900 Å). X-ray diffraction data were collected at 100 K and processed to 1.9 Å resolution with 98.2% completeness and an overall R{sub merge} of 7.8%. The TcDHOD crystals belong to the orthorhombic space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 67.87, b = 71.89, c = 123.27 Å. The presence of two molecules in the asymmetric unit (2 × 34 kDa) gives a crystal volume per protein weight (V{sub M}) of 2.2 Å{sup 3} Da{sup −1} and a solvent content of 44%.

  9. Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi.

    Science.gov (United States)

    Jiang, Lei; Wen, Huaixiu; Shao, Yun; Yu, Ruitao; Liu, Zenggen; Wang, Shuo; Wang, Qilan; Zhao, Xiaohui; Zhang, Peng; Tao, Yanduo; Mei, Lijuan

    2015-10-01

    Traditional Tibetan medicine provides an abundant source of knowledge on human ailments and their treatment. As such, it is necessary to explore their active single compounds used to treat these ailments to discover lead compounds with good pharmacologic properties. In this present work, animal medicine, Osteon Myospalacem Baileyi extracts have been separated using a two-dimensional preparative chromatographic method to obtain single compounds with high purity as part of the following pharmacological research. Five high-purity cyclic dipeptides from chromatography work were studied for their dihydroorotate dehydrogenase inhibitory activity on recombinant human dihydroorotate dehydrogenase enzyme and compound Fr. 1-4 was found to contain satisfying inhibition activity. The molecular modeling study suggests that the active compound Fr. 1-4 may have a teriflunomide-like binding mode. Then, the energy decomposition study suggests that the hydrogen bond between Fr. 1-4 and Arg136 can improve the binding mode to indirectly increase the van der Waals binding energy. All the results above together come to the conclusion that the 2, 5-diketopiperazine structure group can interact with the polar residues well in the active pocket using electrostatic power. If some proper hydrophobic groups can be added to the sides of the 2, 5-diketopiperazine group, it is believed that better 2, 5-diketopiperazine dihydroorotate dehydrogenase inhibitors will be found in the future.

  10. The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

    DEFF Research Database (Denmark)

    Rowland, Paul; Bjørnberg, Olof; Nielsen, Finn S.

    1998-01-01

    Dihydroorotate dehydrogenases (DHODs) catalyze the oxidation of (S)-dihydroorotate to orotate, the fourth step and only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. A description is given of the crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A (DHODA......) complexed with the product of the enzyme reaction orotate. The structure of the complex to 2.0 A resolution has been compared with the structure of the native enzyme. The active site of DHODA is known to contain a water filled cavity buried beneath a highly conserved and flexible loop. In the complex...

  11. A high-throughput fluorescence-based assay for Plasmodium dihydroorotate dehydrogenase inhibitor screening.

    Science.gov (United States)

    Caballero, Iván; Lafuente, María José; Gamo, Francisco-Javier; Cid, Concepción

    2016-08-01

    Plasmodium dihydroorotate dehydrogenase (DHODH) is a mitochondrial membrane-associated flavoenzyme that catalyzes the rate-limiting step of de novo pyrimidine biosynthesis. DHODH is a validated target for malaria, and DSM265, a potent inhibitor, is currently in clinical trials. The enzyme catalyzes the oxidation of dihydroorotate to orotate using flavin mononucleotide (FMN) as cofactor in the first half of the reaction. Reoxidation of FMN to regenerate the active enzyme is mediated by ubiquinone (CoQD), which is the physiological final electron acceptor and second substrate of the reaction. We have developed a fluorescence-based high-throughput enzymatic assay to find DHODH inhibitors. In this assay, the CoQD has been replaced by a redox-sensitive fluorogenic dye, resazurin, which changes to a fluorescent state on reduction to resorufin. Remarkably, the assay sensitivity to find competitive inhibitors of the second substrate is higher than that reported for the standard colorimetric assay. It is amenable to 1536-well plates with Z' values close to 0.8. The fact that the human enzyme can also be assayed in the same format opens additional applications of this assay to the discovery of inhibitors to treat cancer, transplant rejection, autoimmune diseases, and other diseases mediated by rapid cellular growth.

  12. Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme.

    Science.gov (United States)

    Knecht, W; Bergjohann, U; Gonski, S; Kirschbaum, B; Löffler, M

    1996-08-15

    Human mitochondrial dihydroorotate dehydrogenase (the fourth enzyme of pyrimidine de novo synthesis) has been overproduced by means of a recombinant baculovirus that contained the human cDNA fragment for this protein. After virus infection and protein expression in Trichoplusia ni cells (BTI-Tn-5B1-4), the subcellular distribution of the recombinant dihydroorotate dehydrogenase was determined by two distinct enzyme-activity assays and by Western blot analysis with anti-(dihydroorotate dehydrogenase) Ig. The targeting of the recombinant protein to the mitochondria of the insect cells was verified. The activity of the recombinant enzyme in the mitochondria of infected cells was about 740-fold above the level of dihydroorotate dehydrogenase in human liver mitochondria. In a three-step procedure, dihydroorotate dehydrogenase was purified to a specific activity of greater than 50 U/mg. Size-exclusion chromatography showed a molecular mass of 42 kDa and confirmed the existence of the fully active enzyme as a monomeric species. Fluorimetric cofactor analysis revealed the presence of FMN in recombinant dihydroorotate dehydrogenase. By kinetics analysis, Km values for dihydroorotate and ubiquinone-50 were found to be 4 microM and 9.9 microM, respectively, while Km values for dihydroorotate and decylubiquinone were 9.4 microM and 13.7 microM, respectively. The applied expression system will allow preparation of large quantities of the enzyme for structure and function studies. Purified recombinant human dihytdroorotate dehydrogenase was tested for its sensitivity to a reported inhibitor A77 1726 (2-hydroxyethyliden-cyanoacetic acid 4-trifluoromethyl anilide), which is the active metabolite of the isoxazole derivative leflunomide [5-methyl-N-(4-trifluoromethyl-phenyl)-4-isoxazole carboximide]. An IC50 value of 1 microM was determined for A77 1726. Detailed kinetics experiments revealed uncompetitive inhibition with respect to dihydroorotate (Kiu = 0.94 microM) and non

  13. Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension

    Energy Technology Data Exchange (ETDEWEB)

    Couto, Sheila G. [Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av. Trabalhador Sao-carlense 400, C.P. 369, 13560-970, Sao Carlos, SP (Brazil); Grupo de Biofisica e Fisica Aplicada a Medicina, Instituto de Fisica, Universidade Federal de Goias, Campus Samambaia, C.P. 131, 74001-970, Goiania, GO (Brazil); Cristina Nonato, M. [Laboratorio de Cristalografia de Proteinas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av. do Cafe S/N, 14040-903, Ribeirao Preto, SP (Brazil); Costa-Filho, Antonio J., E-mail: ajcosta@ffclrp.usp.br [Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av. Trabalhador Sao-carlense 400, C.P. 369, 13560-970, Sao Carlos, SP (Brazil); Departamento de Fisica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Av. Bandeirantes 3900, 14040-901, Ribeirao Preto, SP (Brazil)

    2011-10-28

    Highlights: Black-Right-Pointing-Pointer EcDHODH is a membrane-associated enzyme and a promising target for drug design. Black-Right-Pointing-Pointer Enzyme's N-terminal extension is responsible for membrane association. Black-Right-Pointing-Pointer N-terminal works as a molecular lid regulating access to the protein interior. -- Abstract: Dihydroorotate dehydrogenases (DHODHs) are enzymes that catalyze the fourth step of the de novo synthesis of pyrimidine nucleotides. In this reaction, DHODH converts dihydroorotate to orotate, using a flavine mononucleotide as a cofactor. Since the synthesis of nucleotides has different pathways in mammals as compared to parasites, DHODH has gained much attention as a promising target for drug design. Escherichia coli DHODH (EcDHODH) is a family 2 DHODH that interacts with cell membranes in order to promote catalysis. The membrane association is supposedly made via an extension found in the enzyme's N-terminal. In the present work, we used site directed spin labeling (SDSL) to specifically place a magnetic probe at positions 2, 5, 19, and 21 within the N-terminal and thus monitor, by using Electron Spin Resonance (ESR), dynamics and structural changes in this region in the presence of a membrane model system. Overall, our ESR spectra show that the N-terminal indeed binds to membranes and that it experiences a somewhat high flexibility that could be related to the role of this region as a molecular lid controlling the entrance of the enzyme's active site and thus allowing the enzyme to give access to quinones that are dispersed in the membrane and that are necessary for the catalysis.

  14. 3D-QSAR studies of triazolopyrimidine derivatives of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors using a combination of molecular dynamics, docking, and genetic algorithm-based methods.

    Science.gov (United States)

    Shah, Priyanka; Kumar, Sumit; Tiwari, Sunita; Siddiqi, Mohammad Imran

    2012-07-01

    A series of 35 triazolopyrimidine analogues reported as Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors were optimized using quantum mechanics methods, and their binding conformations were studied by docking and 3D quantitative structure-activity relationship studies. Genetic algorithm-based criteria was adopted for selection of training and test sets while maintaining structural diversity of training and test sets, which is also very crucial for model development and validation. Both the comparative molecular field analyses ([Formula: see text], [Formula: see text]) and comparative molecular similarity indices analyses ([Formula: see text], [Formula: see text]) show excellent correlation and high predictive power. Furthermore, molecular dynamics simulations were performed to explore the binding mode of the two of the most active compounds of the series, 10 and 14. Harmonization in the two simulation results validate the analysis and therefore applicability of docking parameters based on crystallographic conformation of compound 14 bound to receptor molecule. This work provides useful information about the inhibition mechanism of this class of molecules and will assist in the design of more potent inhibitors of PfDHODH.

  15. Lactococcus lactis Dihydroorotate Dehydrogenase A Mutants Reveal Important Facets of the Enzymatic Function

    DEFF Research Database (Denmark)

    Nørager, Sofie Charlotte; Arent, S; Björnberg, Olof

    2003-01-01

    and 1B, and class 2. This division corresponds to differences in cellular location and the nature of the electron acceptor. Herein we report a study of Lactococcus lactis DHODA, a representative of the class 1A enzymes. Based on the DHODA structure we selected seven residues that are highly conserved...

  16. A detailed kinetic study of Mox-1, a plasmid-encoded class C beta-lactamase.

    Science.gov (United States)

    Alba, Jimena; Bauvois, Cedric; Ishii, Yoshikazu; Galleni, Moreno; Masuda, Katsuyoshi; Ishiguro, Masaji; Ito, Masahiko; Frere, Jean-Marie; Yamaguchi, Keizo

    2003-08-29

    Surveys of beta-lactamases in different parts of the world show an important increase in class C beta-lactamases, thus the study of these enzymes is becoming an important issue. We created an overproduction system for Mox-1, a plasmid class C beta-lactamase, by cloning the gene encoding this enzyme, and placing it under the control of a T7 promoter, using vector pET 28a. The enzyme, purified by ion exchange chromatography, was used to obtain the molecular mass (38246), the N-terminal sequence (GEASPVDPLRPVV), and pI (8.9), and to perform a detailed kinetic study. Cephalotin was used as reporter substrate in the case of poor substrates. The kinetic study showed that benzylpenicillin, cephalotin, cefcapene and moxalactam were good substrates for Mox-1 (k(cat)/K(m) values >2.5 x 10(6) M(-1) s(-1)). On the other hand, ceftazidime and cefepime were poor substrates for this enzyme (K(m) values >200 microM). Clavulanic acid had no inhibitory effect on Mox-1 (K(m)=30.2 mM), however aztreonam behaved as an inhibitor of Mox-1 (K(i)=2.85 microM).

  17. Thermodynamic Basis of Electron Transfer in Dihydroorotate Dehydrogenase B from Lactococcus lactis:  Analysis by Potentiometry, EPR Spectroscopy, and ENDOR Spectroscopy

    DEFF Research Database (Denmark)

    Mohnsen, Al-Walid A.; Rigby, Stephen E. J.; Jensen, Kaj Frank

    2004-01-01

    Dihydroorotate dehydrogenase B (DHODB) is a complex iron-sulfur flavoprotein that catalyzes the conversion of dihydroorotate to orotate and the reduction of NAD+. The enzyme is a dimer of heterodimers containing an FMN, an FAD, and a 2Fe-2S center. UV-visible, EPR, and ENDOR spectroscopies have...... similar to those recorded for the blue semiquinone of free flavins in aqueous solution, thus confirming the presence of this species in DHODB. Spectral features observed during EPR spectroscopy of dithionite-reduced DHODB are consistent with the midpoint reduction potentials determined using UV-visible...

  18. Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

    Energy Technology Data Exchange (ETDEWEB)

    Booker, Michael L.; Bastos, Cecilia M.; Kramer, Martin L.; Barker, Jr., Robert H.; Skerlj, Renato; Sidhu, Amar Bir; Deng, Xiaoyi; Celatka, Cassandra; Cortese, Joseph F.; Guerrero Bravo, Jose E.; Crespo Llado, Keila N.; Serrano, Adelfa E.; Angulo-Barturen, Iñigo; Jiménez-Díaz, María Belén; Viera, Sara; Garuti, Helen; Wittlin, Sergio; Papastogiannidis, Petros; Lin, Jing-wen; Janse, Chris J.; Khan, Shahid M.; Duraisingh, Manoj; Coleman, Bradley; Goldsmith, Elizabeth J.; Phillips, Margaret A.; Munoz, Benito; Wirth, Dyann F.; Klinger, Jeffrey D.; Wiegand, Roger; Sybertz, Edmund (Leiden-MC); (Puerto Rico); (STPHI); (Harvard); (GSK); (Genzyme); (UTSMC)

    2010-11-22

    Plasmodium falciparum, the causative agent of the most deadly form of human malaria, is unable to salvage pyrimidines and must rely on de novo biosynthesis for survival. Dihydroorotate dehydrogenase (DHODH) catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and represents a potential target for anti-malarial therapy. A high throughput screen and subsequent medicinal chemistry program identified a series of N-alkyl-5-(1H-benzimidazol-1-yl)thiophene-2-carboxamides with low nanomolar in vitro potency against DHODH from P. falciparum, P. vivax, and P. berghei. The compounds were selective for the parasite enzymes over human DHODH, and x-ray structural data on the analog Genz-667348, demonstrated that species selectivity could be attributed to amino acid differences in the inhibitor-binding site. Compounds from this series demonstrated in vitro potency against the 3D7 and Dd2 strains of P. falciparum, good tolerability and oral exposure in the mouse, and ED{sub 50} values in the 4-day murine P. berghei efficacy model of 13-21 mg/kg/day with oral twice-daily dosing. In particular, treatment with Genz-667348 at 100 mg/kg/day resulted in sterile cure. Two recent analogs of Genz-667348 are currently undergoing pilot toxicity testing to determine suitability as clinical development candidates.

  19. Identification of potential inhibitors for oncogenic target of dihydroorotate dehydrogenase using in silico approaches

    Science.gov (United States)

    Surekha, Kanagarajan; Nachiappan, Mutharasappan; Prabhu, Dhamodharan; Choubey, Sanjay Kumar; Biswal, Jayashree; Jeyakanthan, Jeyaraman

    2017-01-01

    Dihydroorotate dehydrogenase (DHODH) plays a major role in the rate limiting step of de novo pyrimidine biosynthesis pathway and it is pronounced as a novel target for drug development of cancer. The currently available drugs against DHODH are ineffective and bear various side effects. Three-dimensional structure of the targeted protein was constructed using molecular modeling approach followed by 100 ns molecular dynamics simulations. In this study, High Throughput Virtual Screening (HTVS) was performed using various compound libraries to identify pharmacologically potential molecules. The top four identified lead molecules includes NCI_47074, HitFinder_7630, Binding_66981 and Specs_108872 with high docking score of -9.45, -8.29, -8.04 and -8.03 kcal/mol and the corresponding binding free energy were -16.25, -56.37, -26.93 and -48.04 kcal/mol respectively. Arg122, Arg185, Glu255 and Gly257 are the key residues found to be interacting with the ligands. Molecular dynamics simulations of DHODH-inhibitors complexes were performed to assess the stability of various conformations from complex structures of TtDHODH. Furthermore, stereoelectronic features of the ligands were explored to facilitate charge transfer during the protein-ligand interactions using Density Functional Theoretical approach. Based on in silico analysis, the ligand NCI_47074 ((2Z)-3-({6-[(2Z)-3-carboxylatoprop-2-enamido]pyridin-2-yl}carbamoyl)prop-2-enoate) was found to be the most potent lead molecule which was validated using energetic and electronic parameters and it could serve as a template for designing effective anticancerous drug molecule.

  20. 32 CFR 1630.11 - Class 1-A-0: Conscientious objector available for noncombatant military service only.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Class 1-A-0: Conscientious objector available for noncombatant military service only. 1630.11 Section 1630.11 National Defense Other Regulations...: Conscientious objector available for noncombatant military service only. In accord with part 1636 of...

  1. Characterization and expression pattern ofpouII1,a novel class Ⅱ POU gene in zebrafish

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    POU domain transcription factors that share a conserved DNA-binding domain, POU domain, are important regulators for the development of embryos in various animal species. A novel zebrafish POU domain gene, pouII1has been cloned. The pouII1 cDNA is 2080 kb in length and encodes a putative polypeptide of 596 amino acids. It is placed into class Ⅱ POU family since it shares a high degree of homology with the known members of this family.Northern hybridization identifies a major transcript of approximately 2.1 kb that was present in embryos at the single-cell stage throughout 24 h postfertilizafion. The whole mountin situ hybridization shows thatpouII1 transcripts are present in the single-cell embryos, strongly suggesting that these transcripts are of maternal origin. During early development of the embryos, pouII1 mRNA was ubiquitously distributed in all cells and tissues. The transcripts are gradually limited to brains and become completely undetectable by day 3. To our knowledge, pouII1 is the first class Ⅱ POU gene identified in zebrafish.``

  2. Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy.

    Science.gov (United States)

    Mohsen, Al-Walid A; Rigby, Stephen E J; Jensen, Kaj Frank; Munro, Andrew W; Scrutton, Nigel S

    2004-06-01

    Dihydroorotate dehydrogenase B (DHODB) is a complex iron-sulfur flavoprotein that catalyzes the conversion of dihydroorotate to orotate and the reduction of NAD(+). The enzyme is a dimer of heterodimers containing an FMN, an FAD, and a 2Fe-2S center. UV-visible, EPR, and ENDOR spectroscopies have been used to determine the reduction potentials of the flavins and the 2Fe-2S center and to characterize radicals and their interactions. Reductive titration using dithionite indicates a five-electron capacity for DHODB. The midpoint reduction potential of the 2Fe-2S center (-212 +/- 3 mV) was determined from analysis of absorption data at 540 nm, where absorption contributions from the two flavins are small. The midpoint reduction potentials of the oxidized/semiquinone (E(1)) and semiquinone/hydroquinone (E(2)) couples for the FMN (E(1) = -301 +/- 6 mV; E(2) = -252 +/- 8 mV) and FAD (E(1) = -312 +/- 6 mV; E(2) = -297 +/- 5 mV) were determined from analysis of spectral changes at 630 nm. Corresponding values for the midpoint reduction potentials for FMN (E(1) = -298 +/- 4 mV; E(2) = -259 +/- 5 mV) in the isolated catalytic subunit (subunit D, which lacks the 2Fe-2S center and FAD) are consistent with the values determined for the FMN couples in DHODB. During reductive titration of DHODB, small amounts of the neutral blue semiquinone are observed at approximately 630 nm, consistent with the measured midpoint reduction potentials of the flavins. An ENDOR spectrum of substrate-reduced DHODB identifies hyperfine couplings to proton nuclei similar to those recorded for the blue semiquinone of free flavins in aqueous solution, thus confirming the presence of this species in DHODB. Spectral features observed during EPR spectroscopy of dithionite-reduced DHODB are consistent with the midpoint reduction potentials determined using UV-visible spectroscopy and further identify an unusual EPR signal with very small rhombic anisotropy and g values of 2.02, 1.99, and 1.96. This unusual

  3. 3D-QSAR Studies on a Series of Dihydroorotate Dehydrogenase Inhibitors: Analogues of the Active Metabolite of Leflunomide

    Directory of Open Access Journals (Sweden)

    Hong-Guang Du

    2011-05-01

    Full Text Available The active metabolite of the novel immunosuppressive agent leflunomide has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH. This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. Self-organizing molecular field analysis (SOMFA, a simple three-dimensional quantitative structure-activity relationship (3D-QSAR method is used to study the correlation between the molecular properties and the biological activities of a series of analogues of the active metabolite. The statistical results, cross-validated rCV2 (0.664 and non cross-validated r2 (0.687, show a good predictive ability. The final SOMFA model provides a better understanding of DHODH inhibitor-enzyme interactions, and may be useful for further modification and improvement of inhibitors of this important enzyme.

  4. Effects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro.

    Science.gov (United States)

    Kamyingkird, Ketsarin; Cao, Shinuo; Tuvshintulga, Bumduuren; Salama, Akram; Mousa, Ahmed Abdelmoniem; Efstratiou, Artemis; Nishikawa, Yoshifumi; Yokoyama, Naoaki; Igarashi, Ikuo; Xuan, Xuenan

    2017-05-01

    Theileria equi and Babesia caballi are the causative agents of equine piroplasmosis (EP), which affects equine production in various parts of the world. However, a safe and effective drug is not currently available for treatment of EP. Dihydroorotate dehydrogenase (DHODH) is the fourth enzyme in the de novo pyrimidine synthesis pathway and has been known as a novel drug target for several apicomplexan protozoan parasites. In this study, we evaluated four DHODH inhibitors; atovaquone (ATV), leflunomide (LFN), brequinar (Breq), and 7-hydroxy-5-[1,2,4] triazolo [1,5,a] pyrimidine (TAZ) on the growth of T. equi and B. caballi in vitro and compared them to diminacene aceturate (Di) as the control drug. The growth of T. equi and B. caballi was significantly hindered by all inhibitors except TAZ. The half maximal inhibitory concentration (IC50) of ATV, LFN, Breq and Di against T. equi was approximately 0.028, 109, 11 and 40 μM, respectively, whereas the IC50 of ATV, LFN, Breq and Di against B. caballi was approximately 0.128, 193, 5.2 and 16.2 μM, respectively. Using bioinformatics and Western blot analysis, we showed that TeDHODH was similar to other Babesia parasite DHODHs, and confirmed that targeting DHODHs could be useful for the development of novel chemotherapeutics for treatment of EP.

  5. Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells.

    Science.gov (United States)

    Mohamad Fairus, A K; Choudhary, B; Hosahalli, S; Kavitha, N; Shatrah, O

    2017-04-01

    Dihydroorotate dehydrogenase (DHODH) is the key enzyme in de novo biosynthesis of pyrimidine in both prokaryotes and eukaryotes. The de novo pathway of pyrimidine biosynthesis is essential in cancer cells proliferation. Leflunomide is an approved DHODH inhibitor that has been widely used for the treatment of arthritis. Similarly, brequinar sodium is another DHODH inhibitor that showed anti-tumour effect in MC38 colon carcinoma cells when used in combination with fluorouracil. Despite the potential role of DHODH inhibitors in cancer therapy, their mechanisms of action remain obscure and await further elucidation. Here, we evaluated the effect of DHODH inhibitors on the production of ATP and ROS in sensitive and non-sensitive breast cancer cells. Subsequently, the effects of DHODH inhibitors on cell cycle as well as on signalling molecules such as p53, p65 and STAT6 were evaluated in sensitive T-47D and non-sensitive MDAMB-436 cells. The correlations between DHODH protein expression, proliferation speed and sensitivity to DHODH inhibitors were also investigated in a panel of cancer cell lines. DHODH inhibitors-sensitive T-47D and MDAMB-231 cells appeared to preserve ROS production closely to endogenous ROS level whereas the opposite was observed in non-sensitive MDAMB-436 and W3.006 cells. In addition, we observed approximately 90% of intracellular ATP depletion in highly sensitive T-47D and MDAMB-231 cells compared to non-sensitive MDAMB-436 cells. There was significant over-expression of p53, p65 and STAT6 signalling molecules in sensitive cells which may be involved in mediating the S-phase arrest in cell cycle progression. The current study suggests that DHODH inhibitors are most effective in cells that express high levels of DHODH enzyme. The inhibition of cell proliferation by these inhibitors appears to be accompanied by ROS production as well as ATP depletion. The increase in expression of signalling molecules observed may be due to pyrimidine depletion

  6. Crystal structure of Mox-1, a unique plasmid-mediated class C β-lactamase with hydrolytic activity towards moxalactam.

    Science.gov (United States)

    Oguri, Takuma; Furuyama, Takamitsu; Okuno, Takashi; Ishii, Yoshikazu; Tateda, Kazuhiro; Bonomo, Robert A; Shimizu-Ibuka, Akiko

    2014-07-01

    Mox-1 is a unique plasmid-mediated class C β-lactamase that hydrolyzes penicillins, cephalothin, and the expanded-spectrum cephalosporins cefepime and moxalactam. In order to understand the unique substrate profile of this enzyme, we determined the X-ray crystallographic structure of Mox-1 β-lactamase at a 1.5-Å resolution. The overall structure of Mox-1 β-lactamase resembles that of other AmpC enzymes, with some notable exceptions. First, comparison with other enzymes whose structures have been solved reveals significant differences in the composition of amino acids that make up the hydrogen-bonding network and the position of structural elements in the substrate-binding cavity. Second, the main-chain electron density is not observed in two regions, one containing amino acid residues 214 to 216 positioned in the Ω loop and the other in the N terminus of the B3 β-strand corresponding to amino acid residues 303 to 306. The last two observations suggest that there is significant structural flexibility of these regions, a property which may impact the recognition and binding of substrates in Mox-1. These important differences allow us to propose that the binding of moxalactam in Mox-1 is facilitated by the avoidance of steric clashes, indicating that a substrate-induced conformational change underlies the basis of the hydrolytic profile of Mox-1 β-lactamase.

  7. Comparative studies of vertebrate scavenger receptor class B type 1: a high-density lipoprotein binding protein

    Directory of Open Access Journals (Sweden)

    Holmes RS

    2012-06-01

    Full Text Available Roger S Holmes,1,2 Laura A Cox11Department of Genetics and Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA; 2School of Biomolecular and Physical Sciences, Griffith University, Nathan, Queensland, AustraliaAbstract: Scavenger receptor class B type 1 protein (SCARB1 plays an essential role in cholesterol homeostasis and functions in binding high density lipoprotein cholesterol (HDL in liver and other tissues of the body. SCARB1 also functions in lymphocyte homeostasis and in the uptake of hepatitis C virus (HCV by the liver. A genetic deficiency of this protein results in autoimmune disorders and significant changes in blood cholesterol phenotype. Comparative SCARB1 amino acid sequences and structures and SCARB1 gene locations were examined using data from several vertebrate genome projects. Vertebrate SCARB1 sequences shared 50%–99% identity as compared with 28%–31% sequence identities with other CD36-like superfamily members, ie, SCARB2 and SCARB3 (also called CD36. At least eight N-glycosylation sites were conserved among most of the vertebrate SCARB1 proteins examined. Sequence alignments, key amino acid residues, and conserved predicted secondary structures were also studied, including: cytoplasmic, transmembrane, and exoplasmic sequences; conserved N-terminal and C-terminal transmembrane glycines which participate in oligomer formation; conserved cystine disulfides and a free SH residue which participates in lipid transport; carboxyl terminal PDZ-binding domain sequences (Ala507-Arg/Lys508-Leu509; and 30 conserved proline and 18 conserved glycine residues, which may contribute to short loop formation within the exoplasmic HDL-binding sequence. Vertebrate SCARB1 genes usually contained 12 coding exons. The human SCARB1 gene contained CpG islands, micro RNA binding sites, and several transcription factor binding sites (including PPARG which may contribute to the high level (13.7 times

  8. Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity

    Science.gov (United States)

    Li, Shiliang; Luan, Guoqin; Ren, Xiaoli; Song, Wenlin; Xu, Liuxin; Xu, Minghao; Zhu, Junsheng; Dong, Dong; Diao, Yanyan; Liu, Xiaofeng; Zhu, Lili; Wang, Rui; Zhao, Zhenjiang; Xu, Yufang; Li, Honglin

    2015-01-01

    Human dihydroorotate dehydrogenase (hDHODH) is an attractive therapeutic target for the treatment of rheumatoid arthritis, transplant rejection and other autoimmune diseases. Based on the X-ray structure of hDHODH in complex with lead compound 7, a series of benzylidenehydrazinyl-substituted thiazole derivatives as potent inhibitors of hDHODH were designed and synthesized, of which 19 and 30 were the most potent with IC50 values in the double-digit nanomolar range. Moreover, compound 19 displayed significant anti-arthritic effects and favorable pharmacokinetic profiles in vivo. Further X-ray structure and SAR analyses revealed that the potencies of the designed inhibitors were partly attributable to additional water-mediated hydrogen bond networks formed by an unexpected buried water between hDHODH and the 2-(2-methylenehydrazinyl)thiazole scaffold. This work not only elucidates promising scaffolds targeting hDHODH for the treatment of rheumatoid arthritis, but also demonstrates that the water-mediated hydrogen bond interaction is an important factor in molecular design and optimization. PMID:26443076

  9. Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

    Energy Technology Data Exchange (ETDEWEB)

    Coteron, Jose M.; Marco, Maria; Esquivias, Jorge; Deng, Xiaoyi; White, Karen L.; White, John; Koltun, Maria; El Mazouni, Farah; Kokkonda, Sreekanth; Katneni, Kasiram; Bhamidipati, Ravi; Shackleford, David M.; Angulo-Barturen, Inigo; Ferrer, Santiago B.; Jimenez-Diaz, Maria Belen; Gamo, Francisco-Javier; Goldsmith, Elizabeth J.; Charman, William N.; Bathurst, Ian; Floyd, David; Matthews, David; Burrows, Jeremy N.; Rathod, Pradipsinh K.; Charman, Susan A.; Phillips, Margaret A. (UWASH); (MMV, Switzerland); (GSK); (Monash); (UW); (UTSMC)

    2012-02-27

    Drug therapy is the mainstay of antimalarial therapy, yet current drugs are threatened by the development of resistance. In an effort to identify new potential antimalarials, we have undertaken a lead optimization program around our previously identified triazolopyrimidine-based series of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. The X-ray structure of PfDHODH was used to inform the medicinal chemistry program allowing the identification of a potent and selective inhibitor (DSM265) that acts through DHODH inhibition to kill both sensitive and drug resistant strains of the parasite. This compound has similar potency to chloroquine in the humanized SCID mouse P. falciparum model, can be synthesized by a simple route, and rodent pharmacokinetic studies demonstrated it has excellent oral bioavailability, a long half-life and low clearance. These studies have identified the first candidate in the triazolopyrimidine series to meet previously established progression criteria for efficacy and ADME properties, justifying further development of this compound toward clinical candidate status.

  10. A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

    Science.gov (United States)

    Phillips, Margaret A.; White, Karen L.; Kokkonda, Sreekanth; Deng, Xiaoyi; White, John; Mazouni, Farah El; Marsh, Kennan; Tomchick, Diana R.; Manjalanagara, Krishne; Rudra, Kakali Rani; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N; Marfurt, Jutta; Shackleford, David M.; Chiu, Francis C.K.; Campbell, Michael; Jimenez-Diaz, Maria Belen; Bazaga, Santiago Ferrer; Angulo-Barturen, Iñigo; Martinez, Maria Santos; Lafuente-Monasterio, Maria; Kaminsky, Werner; Silue, Kigbafori; Zeeman, Anne-Marie; Kocken, Clemens; Leroy, Didier; Blasco, Benjamin; Rossignol, Emilie; Rueckle, Thomas; Matthews, Dave; Burrows, Jeremy N.; Waterson, David; Palmer, Michael J.; Rathod, Pradipsinh K.; Charman, Susan A.

    2016-01-01

    The emergence of drug resistant malaria parasites continues to hamper efforts to control this lethal disease. Dihydroorotate dehydrogenase has recently been validated as a new target for the treatment of malaria and a selective inhibitor (DSM265) of the Plasmodium enzyme is currently in clinical development. With the goal of identifying a backup compound to DSM265, we explored replacement of the SF5-aniline moiety of DSM265 with a series of CF3-pyridinyls, while maintaining the core triazolopyrimidine scaffold. This effort led to the identification of DSM421, which has improved solubility, lower intrinsic clearance and increased plasma exposure after oral dosing compared to DSM265, while maintaining a long predicted human half-life. Its improved physical and chemical properties will allow it to be formulated more readily than DSM265. DSM421 showed excellent efficacy in the SCID mouse model of P. falciparum malaria that supports the prediction of a low human dose (<200 mg). Importantly DSM421 showed equal activity against both P. falciparum and P. vivax field isolates, while DSM265 was more active on P. falciparum. DSM421 has the potential to be developed as a single dose cure or once-weekly chemopreventative for both P. falciparum and P. vivax malaria leading to its advancement as a preclinical development candidate. PMID:27641613

  11. In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

    Science.gov (United States)

    Ross, Leila S; Gamo, Francisco Javier; Lafuente-Monasterio, Maria José; Singh, Onkar M P; Rowland, Paul; Wiegand, Roger C; Wirth, Dyann F

    2014-06-27

    Malaria is a preventable and treatable disease; yet half of the world's population lives at risk of infection, and an estimated 660,000 people die of malaria-related causes every year. Rising drug resistance threatens to make malaria untreatable, necessitating both the discovery of new antimalarial agents and the development of strategies to identify and suppress the emergence and spread of drug resistance. We focused on in-development dihydroorotate dehydrogenase (DHODH) inhibitors. Characterizing resistance pathways for antimalarial agents not yet in clinical use will increase our understanding of the potential for resistance. We identified resistance mechanisms of Plasmodium falciparum (Pf) DHODH inhibitors via in vitro resistance selections. We found 11 point mutations in the PfDHODH target. Target gene amplification and unknown mechanisms also contributed to resistance, albeit to a lesser extent. These mutant parasites were often hypersensitive to other PfDHODH inhibitors, which immediately suggested a novel combination therapy approach to preventing resistance. Indeed, a combination of wild-type and mutant-type selective inhibitors led to resistance far less often than either drug alone. The effects of point mutations in PfDHODH were corroborated with purified recombinant wild-type and mutant-type PfDHODH proteins, which showed the same trends in drug response as the cognate cell lines. Comparative growth assays demonstrated that two mutant parasites grew less robustly than their wild-type parent, and the purified protein of those mutants showed a decrease in catalytic efficiency, thereby suggesting a reason for the diminished growth rate. Co-crystallography of PfDHODH with three inhibitors suggested that hydrophobic interactions are important for drug binding and selectivity.

  12. BEL-1, a Novel Clavulanic Acid-Inhibited Extended-Spectrum β-Lactamase, and the Class 1 Integron In120 in Pseudomonas aeruginosa

    Science.gov (United States)

    Poirel, Laurent; Brinas, Laura; Verlinde, Annemie; Ide, Louis; Nordmann, Patrice

    2005-01-01

    Screening by a double-disk synergy test identified a Pseudomonas aeruginosa isolate that produced a clavulanic acid-inhibited expanded-spectrum β-lactamase (ESBL). Cloning and sequencing identified a novel ESBL, BEL-1, weakly related to other Ambler class A ESBLs. β-Lactamase BEL-1 hydrolyzed significantly most expanded-spectrum cephalosporins and aztreonam, and its activity was inhibited by clavulanic acid, tazobactam, cefoxitin, moxalactam, and imipenem. This chromosome-encoded ESBL gene was embedded in a class 1 integron containing three other gene cassettes. In addition, this integron was bracketed by Tn1404 transposon sequences at its right end and by P. aeruginosa-specific sequences at its left end. PMID:16127048

  13. Sinorhizobium meliloti-induced chitinase gene expression in Medicago truncatula ecotype R108-1: a comparison between symbiosis-specific class V and defence-related class IV chitinases.

    Science.gov (United States)

    Salzer, Peter; Feddermann, Nadja; Wiemken, Andres; Boller, Thomas; Staehelin, Christian

    2004-08-01

    The Medicago truncatula (Gaertn.) ecotypes Jemalong A17 and R108-1 differ in Sinorhizobium meliloti-induced chitinase gene expression. The pathogen-inducible class IV chitinase gene, Mtchit 4, was strongly induced during nodule formation of the ecotype Jemalong A17 with the S. meliloti wild-type strain 1021. In the ecotype R108-1, the S. meliloti wild types Sm1021 and Sm41 did not induce Mtchit 4 expression. On the other hand, expression of the putative class V chitinase gene, Mtchit 5, was found in roots of M. truncatula cv. R108-1 nodulated with either of the rhizobial strains. Mtchit 5 expression was specific for interactions with rhizobia. It was not induced in response to fungal pathogen attack, and not induced in roots colonized with arbuscular mycorrhizal (AM) fungi. Elevated Mtchit 5 gene expression was first detectable in roots forming nodule primordia. In contrast to Mtchit 4, expression of Mtchit 5 was stimulated by purified Nod factors. Conversely, Mtchit 4 expression was strongly elevated in nodules formed with the K-antigen-deficient mutant PP699. Expression levels of Mtchit 5 were similarly increased in nodules formed with PP699 and its parental wild-type strain Sm41. Phylogenetic analysis of the deduced amino acid sequences of Mtchit 5 (calculated molecular weight = 41,810 Da, isoelectric point pH 7.7) and Mtchit 4 (calculated molecular weight 30,527 Da, isoelectric point pH 4.9) revealed that the putative Mtchit 5 chitinase forms a separate clade within class V chitinases of plants, whereas the Mtchit 4 chitinase clusters with pathogen-induced class IV chitinases from other plants. These findings demonstrate that: (i) Rhizobium-induced chitinase gene expression in M. truncatula occurs in a plant ecotype-specific manner, (ii) Mtchit 5 is a putative chitinase gene that is specifically induced by rhizobia, and (iii) rhizobia-specific and defence-related chitinase genes are differentially influenced by rhizobial Nod factors and K antigens.

  14. Characterization of VCC-1, a Novel Ambler Class A Carbapenemase from Vibrio cholerae Isolated from Imported Retail Shrimp Sold in Canada.

    Science.gov (United States)

    Mangat, Chand S; Boyd, David; Janecko, Nicol; Martz, Sarah-Lynn; Desruisseau, Andrea; Carpenter, Michael; Reid-Smith, Richard J; Mulvey, Michael R

    2016-01-11

    One of the core goals of the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) is to monitor major meat commodities for antimicrobial resistance. Targeted studies with methodologies based on core surveillance protocols are used to examine other foods, e.g., seafood, for antimicrobial resistance to detect resistances of concern to public health. Here we report the discovery of a novel Ambler class A carbapenemase that was identified in a nontoxigenic strain of Vibrio cholerae (N14-02106) isolated from shrimp that was sold for human consumption in Canada. V. cholerae N14-02106 was resistant to penicillins, carbapenems, and monobactam antibiotics; however, PCR did not detect common β-lactamases. Bioinformatic analysis of the whole-genome sequence of V. cholerae N14-02106 revealed on the large chromosome a novel carbapenemase (referred to here as VCC-1, for Vibrio cholerae carbapenemase 1) with sequence similarity to class A enzymes. Two copies of blaVCC-1 separated and flanked by ISVch9 (i.e., 3 copies of ISVch9) were found in an acquired 8.5-kb region inserted into a VrgG family protein gene. Cloned blaVCC-1 conferred a β-lactam resistance profile similar to that in V. cholerae N14-02106 when it was transformed into a susceptible laboratory strain of Escherichia coli. Purified VCC-1 was found to hydrolyze penicillins, 1st-generation cephalosporins, aztreonam, and carbapenems, whereas 2nd- and 3rd-generation cephalosporins were poor substrates. Using nitrocefin as a reporter substrate, VCC-1 was moderately inhibited by clavulanic acid and tazobactam but not EDTA. In this report, we present the discovery of a novel class A carbapenemase from the food supply.

  15. 二氢乳清酸脱氢酶靶向抗疟药研究进展%Proceedings on Dihydroorotate Dehydrogenase-Targeted Antimalarial Research

    Institute of Scientific and Technical Information of China (English)

    赵彩亮; 兰晶; 贝祝春; 杨恒林

    2013-01-01

    Malaria remains the one of major global health threats that leads to significant morbidity and mortali⁃ty, especially in Africa. The emerging and development of drug resistance has compromised most of current antima⁃larial drugs used clinically and made the development of new antimalarial drugs urgent. The completion of Plasmo⁃dium falciparum genome and growing knowledge of parasite biology are promoting the discovery of novel antimalari⁃al targets. The pyrimidine biosynthesis pathway illustrates one best sample of successful identification of antimalari⁃al drug targets. This review focused on recent efforts to explore the fourth enzyme in the de novo pyrimidine bio⁃synthesis pathway of P.falciparum, dihydroorotate dehydrogenase(PfDHODH), as a new target for antimalarial drugs discovery. By high throughput screening and other methods, several chemical scaffolds have been identified as po⁃tent inhibitors of PfDHODH, and shown strong selectivity for malarial enzyme over its human counterpart. Some of them have also showed potent activity against P.falciparum in whole cell assay with good correlation between activi⁃ty on the enzyme and parasite. Lead optimization of a triazolopyrimidine-based series has sought out an analog with good metablic stability and efficacy against P.bergei infected mouse model. These data confirmed that the dis⁃covery and development of antimalarial agents targeting PfDHODH has a great promise.%  疟疾是全球危害最严重的传染性疾病之一,尤其是在非洲,发病率与死亡率仍居高不下。抗药性的出现和发展使大多数现有抗疟药在临床上失去了效用,研究和开发新型抗疟药已成为当前疟疾防治研究的迫切需求。随着恶性疟原虫基因组测序的完成和对疟原虫生物学认知的不断深入,寻找抗疟新靶点的研究得以快速发展。嘧啶生物合成途径是经临床确证有效的抗疟靶点的典范。我们简要综述了近年来

  16. Anticancer properties of distinct antimalarial drug classes.

    Directory of Open Access Journals (Sweden)

    Rob Hooft van Huijsduijnen

    Full Text Available We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and DHFR (dihydrofolate reductase inhibitors effected potent inhibition of proliferation with IC50s in the nM- low µM range, whereas a DHODH (dihydroorotate dehydrogenase and a putative kinase inhibitor displayed no activity. Furthermore, significant synergies were identified with erlotinib, imatinib, cisplatin, dasatinib and vincristine. Cluster analysis of the antimalarials based on their differential inhibition of the various cancer lines clearly segregated the synthetic peroxides OZ277 and OZ439 from the artemisinin cluster that included artesunate, dihydroartemisinin and artemisone, and from the DHFR inhibitors pyrimethamine and P218 (a parasite DHFR inhibitor, emphasizing their shared mode of action. In order to further understand the basis of the selectivity of these compounds against different cancers, microarray-based gene expression data for 85 of the used cell lines were generated. For each compound, distinct sets of genes were identified whose expression significantly correlated with compound sensitivity. Several of the antimalarials tested in this study have well-established and excellent safety profiles with a plasma exposure, when conservatively used in malaria, that is well above the IC50s that we identified in this study. Given their unique mode of action and potential for unique synergies with established anticancer drugs, our results provide a strong basis to further explore the potential application of these compounds in cancer in pre-clinical or and clinical settings.

  17. MadR1, a Mycobacterium tuberculosis cell cycle stress response protein that is a member of a widely conserved protein class of prokaryotic, eukaryotic and archeal origin.

    Science.gov (United States)

    Crew, Rebecca; Ramirez, Melissa V; England, Kathleen; Slayden, Richard A

    2015-05-01

    Stress-induced molecular programs designed to stall division progression are nearly ubiquitous in bacteria, with one well-known example being the participation of the SulA septum inhibiting protein in the SOS DNA damage repair response. Mycobacteria similarly demonstrate stress-altered growth kinetics, however no such regulators have been found in these organisms. We therefore set out to identify SulA-like regulatory proteins in Mycobacterium tuberculosis. A bioinformatics modeling-based approach led to the identification of rv2216 as encoding for a protein with weak similarity to SulA, further analysis distinguished this protein as belonging to a group of uncharacterized growth promoting proteins. We have named the mycobacterial protein encoded by rv2216 morphology altering division regulator protein 1, MadR1. Overexpression of madR1 modulated cell length while maintaining growth kinetics similar to wild-type, and increased the proportion of bent or V-form cells in the population. The presence of MadR1-GFP at regions of cellular elongation (poles) and morphological differentiation (V-form) suggests MadR1 involvement in phenotypic heterogeneity and longitudinal cellular growth. Global transcriptional analysis indicated that MadR1 functionality is linked to lipid editing programs required for growth and persistence. This is the first report to differentiate the larger class of these conserved proteins from SulA proteins and characterizes MadR1 effects on the mycobacterial cell.

  18. "Racializing" Class

    Science.gov (United States)

    Hatt-Echeverria, Beth; Urrieta, Luis, Jr.

    2003-01-01

    In an effort to explore how racial and class oppressions intersect, the authors use their autobiographical narratives to depict cultural and experiential continuity and discontinuity in growing up white working class versus Chicano working class. They specifically focus on "racializing class" due to the ways class is often used as a copout by…

  19. Dependent Classes

    DEFF Research Database (Denmark)

    Gasiunas, Vaidas; Mezini, Mira; Ostermann, Klaus

    2007-01-01

    Virtual classes allow nested classes to be refined in subclasses. In this way nested classes can be seen as dependent abstractions of the objects of the enclosing classes. Expressing dependency via nesting, however, has two limitations: Abstractions that depend on more than one object cannot...... be modeled and a class must know all classes that depend on its objects. This paper presents dependent classes, a generalization of virtual classes that expresses similar semantics by parameterization rather than by nesting. This increases expressivity of class variations as well as the flexibility...... of their modularization. Besides, dependent classes complement multi-methods in scenarios where multi-dispatched abstractions rather than multi-dispatched method are needed. They can also be used to express more precise signatures of multi-methods and even extend their dispatch semantics. We present a formal semantics...

  20. Word classes

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    2007-01-01

    This article provides an overview of recent literature and research on word classes, focusing in particular on typological approaches to word classification. The cross-linguistic classification of word class systems (or parts-of-speech systems) presented in this article is based on statements found...... – Adverb, because they have properties that are strongly associated with at least two of these four traditional word classes (e.g. Adjective and Adverb). Finally, this article discusses some of the ways in which word class distinctions interact with other grammatical domains, such as syntax and morphology....

  1. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.

    Science.gov (United States)

    Bago, Ruzica; Malik, Nazma; Munson, Michael J; Prescott, Alan R; Davies, Paul; Sommer, Eeva; Shpiro, Natalia; Ward, Richard; Cross, Darren; Ganley, Ian G; Alessi, Dario R

    2014-11-01

    The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX (phox homology) and FYVE domains. In the present study, we describe a highly selective and potent inhibitor of Vps34, termed VPS34-IN1, that inhibits Vps34 with 25 nM IC50 in vitro, but does not significantly inhibit the activity of 340 protein kinases or 25 lipid kinases tested that include all isoforms of class I as well as class II PI3Ks. Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1 min, without affecting the ability of class I PI3K to regulate Akt. Moreover, we explored whether SGK3 (serum- and glucocorticoid-regulated kinase-3), the only protein kinase known to interact specifically with PtdIns(3)P via its N-terminal PX domain, might be controlled by Vps34. Mutations disrupting PtdIns(3)P binding ablated SGK3 kinase activity by suppressing phosphorylation of the T-loop [PDK1 (phosphoinositide-dependent kinase 1) site] and hydrophobic motif (mammalian target of rapamycin site) residues. VPS34-IN1 induced a rapid ~50-60% loss of SGK3 phosphorylation within 1 min. VPS34-IN1 did not inhibit activity of the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain. Furthermore, class I PI3K inhibitors (GDC-0941 and BKM120) that do not inhibit Vps34 suppressed SGK3 activity by ~40%. Combining VPS34-IN1 and GDC-0941 reduced SGK3 activity ~80-90%. These data suggest SGK3 phosphorylation and hence activity is controlled by two pools of PtdIns(3)P. The first is produced through phosphorylation of PtdIns by Vps34 at the endosome. The second is due to the conversion of class I PI3K product, PtdIns(3,4,5)P3 into PtdIns(3)P, via the sequential actions of the Ptd

  2. Class size versus class composition

    DEFF Research Database (Denmark)

    Jones, Sam

    Raising schooling quality in low-income countries is a pressing challenge. Substantial research has considered the impact of cutting class sizes on skills acquisition. Considerably less attention has been given to the extent to which peer effects, which refer to class composition, also may affect...... bias from omitted variables, the preferred IV results indicate considerable negative effects due to larger class sizes and larger numbers of overage-for-grade peers. The latter, driven by the highly prevalent practices of grade repetition and academic redshirting, should be considered an important...

  3. Class size versus class composition

    DEFF Research Database (Denmark)

    Jones, Sam

    Raising schooling quality in low-income countries is a pressing challenge. Substantial research has considered the impact of cutting class sizes on skills acquisition. Considerably less attention has been given to the extent to which peer effects, which refer to class composition, also may affect...... outcomes. This study uses new microdata from East Africa, incorporating test score data for over 250,000 children, to compare the likely efficacy of these two types of interventions. Endogeneity bias is addressed via fixed effects and instrumental variables techniques. Although these may not fully mitigate...

  4. Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior

    DEFF Research Database (Denmark)

    Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe;

    2009-01-01

    Dopamine D(3) antagonism combined with serotonin 5-HT(1A) and 5-HT(2A) receptor occupancy may represent a novel paradigm for developing innovative antipsychotics. The unique pharmacological features of 5i are a high affinity for dopamine D(3), serotonin 5-HT(1A) and 5-HT(2A) receptors, together...... with a low affinity for dopamine D(2) receptors (to minimize extrapyramidal side effects), serotonin 5-HT(2C) receptors (to reduce the risk of obesity under chronic treatment), and for hERG channels (to reduce incidence of torsade des pointes). Pharmacological and biochemical data, including specific c...

  5. Class distinction

    Science.gov (United States)

    White, M. Catherine

    Typical 101 courses discourage many students from pursuing higher level science and math courses. Introductory classes in science and math serve largely as a filter, screening out all but the most promising students, and leaving the majority of college graduates—including most prospective teachers—with little understanding of how science works, according to a study conducted for the National Science Foundation. Because few teachers, particularly at the elementary level, experience any collegiate science teaching that stresses skills of inquiry and investigation, they simply never learn to use those methods in their teaching, the report states.

  6. 32 CFR 1633.6 - Consideration of classes.

    Science.gov (United States)

    2010-07-01

    ... considered the lowest class, according to the following table: Class 1-A-O: Conscientious Objector Available for Noncombatant Military Service Only. Class 1-O: Conscientious Objector to all Military Service. Class 1-O-S: Conscientious Objector to all Military Service (Separated). Class 2-D: Registrant...

  7. Teachers in Class

    Science.gov (United States)

    Van Galen, Jane

    2008-01-01

    In this article, I argue for a closer read of the daily "class work" of teachers, as posited by Reay, 1998. In developing exploratory class portraits of four teachers who occupy distinctive social positions (two from working-class homes now teaching upper-middle-class children and two from upper-middle-class homes now teaching poor children), I…

  8. A Virtual Class Calculus

    DEFF Research Database (Denmark)

    Ernst, Erik; Ostermann, Klaus; Cook, William Randall

    2006-01-01

    Virtual classes are class-valued attributes of objects. Like virtual methods, virtual classes are defined in an object's class and may be redefined within subclasses. They resemble inner classes, which are also defined within a class, but virtual classes are accessed through object instances......, not as static components of a class. When used as types, virtual classes depend upon object identity - each object instance introduces a new family of virtual class types. Virtual classes support large scale program composition techniques, including higher-order hierarchies and family polymorphism. The original...... definition of virtual classes in BETA left open the question of static type safety, since some type errors were not caught until runtime. Later the languages Caesar and gbeta have used a more strict static analysis in order to ensure static type safety. However, the existence of a sound, statically typed...

  9. RxClass

    Data.gov (United States)

    U.S. Department of Health & Human Services — The RxClass Browser is a web application for exploring and navigating through the class hierarchies to find the RxNorm drug members associated with each class....

  10. On differential characteristic classes

    OpenAIRE

    Ho, Man-Ho

    2013-01-01

    In this paper we give explicit formulas of differential characteristic classes of principal $G$-bundles with connections and prove their expected properties. In particular, we obtain explicit formulas for differential Chern classes, differential Pontryagin classes and differential Euler class. Furthermore, we show that the differential Chern class is the unique natural transformation from (Simons-Sullivan) differential $K$-theory to (Cheeger-Simons) differential characters that is compatible ...

  11. Loosely coupled class families

    DEFF Research Database (Denmark)

    Ernst, Erik

    2001-01-01

    are expressed using virtual classes seem to be very tightly coupled internally. While clients have achieved the freedom to dynamically use one or the other family, it seems that any given family contains a xed set of classes and we will need to create an entire family of its own just in order to replace one......Families of mutually dependent classes that may be accessed polymor- phically provide an advanced tool for separation of concerns, in that it enables client code to use a group of instances of related classes safely without depending on the exact classes involved. However, class families which...... of the members with another class. This paper shows how to express class families in such a manner that the classes in these families can be used in many dierent combinations, still enabling family polymorphism and ensuring type safety....

  12. Class 1 Areas

    Data.gov (United States)

    U.S. Environmental Protection Agency — A "Class 1" area is a geographic area recognized by the EPA as being of the highest environmental quality and requiring maximum protection. Class I areas are areas...

  13. PRCR Classes and Activities

    Data.gov (United States)

    Town of Cary, North Carolina — This data is specific to Parks and Recreation classes, workshops, and activities within the course catalog. It contains an entry for upcoming classes.*This data set...

  14. Education and Class.

    Science.gov (United States)

    Van Galen, Jane A.

    2000-01-01

    The working class is nearly invisible in multicultural education literature. Examines the possibilities of a more careful foregrounding of the complexities of social class in shaping life chances, focusing on the educational experiences of working class students and discussing the poor in order to promote understanding of the potential of teacher…

  15. Class, Culture and Politics

    DEFF Research Database (Denmark)

    Harrits, Gitte Sommer

    2013-01-01

    Even though contemporary discussions of class have moved forward towards recognizing a multidimensional concept of class, empirical analyses tend to focus on cultural practices in a rather narrow sense, that is, as practices of cultural consumption or practices of education. As a result......, discussions within political sociology have not yet utilized the merits of a multidimensional conception of class. In light of this, the article suggests a comprehensive Bourdieusian framework for class analysis, integrating culture as both a structural phenomenon co-constitutive of class and as symbolic...

  16. Persian Preposition Classes

    Directory of Open Access Journals (Sweden)

    Marina Pantcheva

    2007-01-01

    Full Text Available In this paper I present the prepositional system in Persian. I show that Persian prepositions can be divided into three classes (Class 1, Class 2a and Class 2b which exhibit distinct syntactic behavior. Then I examine the question of the categorial status of Class 2 prepositions and demonstrate that they are not to be regarded as nouns. Finally I present the extended PP projection of Persian spatial prepositions and argue for a feature-based analysis of the properties they manifest.

  17. Class network routing

    Science.gov (United States)

    Bhanot, Gyan; Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.; Gara, Alan G.; Giampapa, Mark E.; Heidelberger, Philip; Steinmacher-Burow, Burkhard D.; Takken, Todd E.; Vranas, Pavlos M.

    2009-09-08

    Class network routing is implemented in a network such as a computer network comprising a plurality of parallel compute processors at nodes thereof. Class network routing allows a compute processor to broadcast a message to a range (one or more) of other compute processors in the computer network, such as processors in a column or a row. Normally this type of operation requires a separate message to be sent to each processor. With class network routing pursuant to the invention, a single message is sufficient, which generally reduces the total number of messages in the network as well as the latency to do a broadcast. Class network routing is also applied to dense matrix inversion algorithms on distributed memory parallel supercomputers with hardware class function (multicast) capability. This is achieved by exploiting the fact that the communication patterns of dense matrix inversion can be served by hardware class functions, which results in faster execution times.

  18. Fostering a Middle Class

    Institute of Scientific and Technical Information of China (English)

    YAO BIN

    2011-01-01

    Though there is no official definition of "middle class" in China,the tag has become one few Chinese people believe they deserve anyway.In early August,the Chinese Academy of Social Sciences released a report on China's urban development,saying China had a middle-class population of 230 million in 2009,or 37 percent of its urban residents.It also forecast half of city dwellers in China would be part of the middle class by 2023.

  19. ABS 497 Complete Class

    OpenAIRE

    admin

    2015-01-01

    ABS 497 Complete Class   To purchase this material click below link   http://www.assignmentcloud.com/ABS-497/ABS-497-Complete-Class-Guide   For more classes visit   www.assignmentcloud.com   ABS 497 Week 1 Assignment Community Change ABS 497 Week 1 DQ 1 Fabian's Story ABS 497 Week 1 DQ 2 Doug's Story ABS 497 Week 2 DQ 1 Parenting Styles ABS 497 Week 2 DQ 2 Ethnicity and Learning Theory ABS 497 Week 3 ...

  20. Tailor-Made Classes.

    Science.gov (United States)

    Schreirer, Barbara A.

    1978-01-01

    Adapted teaching materials and procedures were developed at Florida State University to help visually handicapped students in the public schools participate in a mainstreamed home economics class. (MF)

  1. The Conversation Class

    Science.gov (United States)

    Jackson, Acy L.

    2012-01-01

    The conversation class occupies a unique place in the process of learning English as a second or foreign language. From the author's own experience in conducting special conversation classes with Persian-speaking adults, he has drawn up a number of simple but important guidelines, some of which he hopes may provide helpful suggestions for the…

  2. Universality classes of inflation

    NARCIS (Netherlands)

    Roest, Diederik

    2014-01-01

    We investigate all single-field, slow-roll inflationary models whose slow-roll parameters scale as 1/N in the limit of a large number of e-folds N. We proof that all such models belong to two universality classes, characterised by a single parameter. One class contains small field models like hillto

  3. Cutting Class Harms Grades

    Science.gov (United States)

    Taylor, Lewis A., III

    2012-01-01

    An accessible business school population of undergraduate students was investigated in three independent, but related studies to determine effects on grades due to cutting class and failing to take advantage of optional reviews and study quizzes. It was hypothesized that cutting classes harms exam scores, attending preexam reviews helps exam…

  4. DEFINING THE MIDDLE CLASS

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Classifying the middle class remains controversial despite its alleged growth China’s cities housed more than 230 million middle-class residents in 2009 or 37 percent of the urban population,according to the 2011 Blue Book of Cities in China released on August 3.

  5. DEFINING THE MIDDLE CLASS

    Institute of Scientific and Technical Information of China (English)

    WANG HAIRONG

    2011-01-01

    China's cities housed more than 230 million middle-class residents in 2009ot 37 percent of the urban population,according to the 2011 Blue Book of Cities in China released on August 3.In China's main urban centers,Beijing and Shanghai,the middle class accounted for 46 percent and 38 percent,respectively,of the local population.

  6. Class II Microcins

    Science.gov (United States)

    Vassiliadis, Gaëlle; Destoumieux-Garzón, Delphine; Peduzzi, Jean

    Class II microcins are 4.9- to 8.9-kDa polypeptides produced by and active against enterobacteria. They are classified into two subfamilies according to their structure and their gene cluster arrangement. While class IIa microcins undergo no posttranslational modification, class IIb microcins show a conserved C-terminal sequence that carries a salmochelin-like siderophore motif as a posttranslational modification. Aside from this C-terminal end, which is the signature of class IIb microcins, some sequence similarities can be observed within and between class II subclasses, suggesting the existence of common ancestors. Their mechanisms of action are still under investigation, but several class II microcins use inner membrane proteins as cellular targets, and some of them are membrane-active. Like group B colicins, many, if not all, class II microcins are TonB- and energy-dependent and use catecholate siderophore receptors for recognition/­translocation across the outer membrane. In that context, class IIb microcins are considered to have developed molecular mimicry to increase their affinity for their outer membrane receptors through their salmochelin-like posttranslational modification.

  7. Generalized Fourier transforms classes

    DEFF Research Database (Denmark)

    Berntsen, Svend; Møller, Steen

    2002-01-01

    The Fourier class of integral transforms with kernels $B(\\omega r)$ has by definition inverse transforms with kernel $B(-\\omega r)$. The space of such transforms is explicitly constructed. A slightly more general class of generalized Fourier transforms are introduced. From the general theory...

  8. Teaching Social Class

    Science.gov (United States)

    Tablante, Courtney B.; Fiske, Susan T.

    2015-01-01

    Discussing socioeconomic status in college classes can be challenging. Both teachers and students feel uncomfortable, yet social class matters more than ever. This is especially true, given increased income inequality in the United States and indications that higher education does not reduce this inequality as much as many people hope. Resources…

  9. Semantic Analysis of Virtual Classes and Nested Classes

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    1999-01-01

    Virtual classes and nested classes are distinguishing features of BETA. Nested classes originated from Simula, but until recently they have not been part of main stream object- oriented languages. C++ has a restricted form of nested classes and they were included in Java 1.1. Virtual classes...... the central elements of the semantic analysis used in the Mjølner BETA compiler....

  10. Social Class Dialogues and the Fostering of Class Consciousness

    Science.gov (United States)

    Madden, Meredith

    2015-01-01

    How do critical pedagogies promote undergraduate students' awareness of social class, social class identity, and social class inequalities in education? How do undergraduate students experience class consciousness-raising in the intergroup dialogue classroom? This qualitative study explores undergraduate students' class consciousness-raising in an…

  11. Class in disguise

    DEFF Research Database (Denmark)

    Faber, Stine Thidemann; Prieur, Annick

    This paper asks how class can have importance in one of the worlds’ most equal societies: Denmark. The answer is that class here appears in disguised forms. The field under study is a city, Aalborg, in the midst of transition from a stronghold of industrialism to a post industrial economy....... The paper picks out two sets of discourses from this city: on the one hand a newspapers discourses about the city’s brand and on the other interviews with female inhabitants about experiences and visions of social differences and divides. The analysis reveals indirect and euphemized forms of class divisions....... The paper also raises questions about how sociological discourses may contribute to the veiling of class....

  12. Classes of Heart Failure

    Science.gov (United States)

    ... Disease Venous Thromboembolism Aortic Aneurysm More Classes of Heart Failure Updated:Sep 28,2016 Doctors usually classify patients' ... Blood Pressure Tracker Find additional helpful resources here Heart Failure • Home • About Heart Failure Introduction Types of Heart ...

  13. IELP Class Observation

    Institute of Scientific and Technical Information of China (English)

    陈了了

    2010-01-01

    @@ As an exchange student majoring in English, I am curious about how English is taught to international students here in America. Therefore, I observed an IELP (Intensive English Learning Program) class in Central Connecticut State University where I study.

  14. Teaching Heterogeneous Classes.

    Science.gov (United States)

    Millrood, Radislav

    2002-01-01

    Discusses an approach to teaching heterogeneous English-as-a-Second/Foreign-Language classes. Draws on classroom research data to describe the features of a success-building lesson context. (Author/VWL)

  15. MKT 438 Complete Class

    OpenAIRE

    admin

    2015-01-01

      To purchase this material click below link   http://www.assignmentcloud.com/MKT-438/MKT-438-Complete-Class-Guide   For more classes visit www.assignmentcloud.com   MKT 438 Week 1 Individual Assignment Defining Public Relation Paper MKT 438 Week 2 Team Assignment Public Relations Campaign Overview Paper MKT 438 Week 3 Individual Assignment Functions of Public Relation Paper MKT 438 Week 3 Team Assignment Public Relations Campaig...

  16. A class in astrobiology

    Science.gov (United States)

    Airieau, S. A.

    1999-09-01

    The goal of this class is to provide basic astrobiology knowledge to upper division science students. The scope is broad and in-depth coverage is not possible in this introductory course. Instead, science students from various branches of academia can acquire a broad basis and understanding of the other fields: astronomy, biology, geology, biochemistry, planetary and space sciences. The class is highly modular and allows instructors to concentrate on or eliminate topics according to their priorities and preferences.

  17. Nordic Walking Classes

    CERN Multimedia

    Fitness Club

    2015-01-01

    Four classes of one hour each are held on Tuesdays. RDV barracks parking at Entrance A, 10 minutes before class time. Spring Course 2015: 05.05/12.05/19.05/26.05 Prices 40 CHF per session + 10 CHF club membership 5 CHF/hour pole rental Check out our schedule and enroll at: https://espace.cern.ch/club-fitness/Lists/Nordic%20Walking/NewForm.aspx? Hope to see you among us! fitness.club@cern.ch

  18. Talking Class in Tehroon

    DEFF Research Database (Denmark)

    Elling, Rasmus Christian; Rezakhani, Khodadad

    2016-01-01

    Persian, like any other language, is laced with references to class, both blatant and subtle. With idioms and metaphors, Iranians can identify and situate others, and thus themselves, within hierarchies of social status and privilege, both real and imagined. Some class-related terms can be traced...... back to medieval times, whereas others are of modern vintage, the linguistic legacy of television shows, pop songs, social media memes or street vernacular. Every day, it seems, an infectious set of phrases appears that make yesterday’s seem embarrassingly antiquated....

  19. BUSN 460 Complete Class

    OpenAIRE

    Laynebaril1

    2017-01-01

    BUSN 460 Complete Class Click Link Below To Buy:   http://hwcampus.com/shop/busn-460-complete-class/     Week 1 DQ 1 Selling your team’s services to CanGo  Week 1 DQ 2 Mission, Vision & Values  Week 2 DQ 1 Planning a Technological Solution  Week 2 DQ 2 Cost Benefit Analysis  Week 3 DQ 1 Flow Charting Processes  Week 3 DQ 2 Implementing Technology  Week 4 DQ 1 Group vs Team  Week  4 DQ 2 Matrixed Employee Environments  Week 5 DQ 1 Pe...

  20. MIDDLE CLASS MOVEMENTS

    OpenAIRE

    Dr. K. Sravana Kumar

    2016-01-01

                The middle class is placed between labour and capital. It neither directly awns the means of production that pumps out the surplus generated by wage labour power, nor does it, by its own labour, produce the surplus which has use and exchange value. Broadly speaking, this class consists of the petty bourgeoisie and the white-collar workers. The former are either self-employed or involved in the distribution of commodities and t...

  1. NR 512 Entire Class

    OpenAIRE

    Laynebaril1

    2017-01-01

     NR 512 Entire Class   Click Link Below To Buy:   http://hwcampus.com/shop/nr-512-entire-class/ Or Visit www.hwcampus.com   NR512 Week 1 Discussion Latest 2017 Integration of Nursing Informatics Skills and Competencies (graded) • Reflect on your own practice. Discuss how informatics is used in your practice. What is your primary area where you would use informatics? NR512 Week 2 Discussion Latest 2017 Wisdom Versus Judgment (graded) How does the conc...

  2. Fostering a Middle Class

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Though there is no official definition of "middle class" in China, the tag has become one few Chinese people believe they deserve anyway.In early August, the Chinese Academy of Social Sciences released a report on China’s urban development,

  3. Teaching Very Large Classes

    Science.gov (United States)

    DeRogatis, Amy; Honerkamp, Kenneth; McDaniel, Justin; Medine, Carolyn; Nyitray, Vivian-Lee; Pearson, Thomas

    2014-01-01

    The editor of "Teaching Theology and Religion" facilitated this reflective conversation with five teachers who have extensive experience and success teaching extremely large classes (150 students or more). In the course of the conversation these professors exchange and analyze the effectiveness of several active learning strategies they…

  4. Class Actions in Denmark

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2009-01-01

    The article deals with the relatively new Danish Act on Class Action (Danish: gruppesøgsmål) which was suggested by The Permanent Council on Civil procedure (Retsplejerådet) of which the article's author is a member. The operability of the new provisions is illustrated through some wellknown Danish...

  5. Class, Cultism, and Multiculturalism.

    Science.gov (United States)

    McLaren, Peter; Farahmandpur, Ramin

    2001-01-01

    Globalization has hurt both developed and developing countries. Capitalism's relations of exploitation can hurt people of color in disabling ways. Discusses the relationships among race, gender, ethnic, and class identities in order to articulate a political framework that moves toward transnational ethnic alliances, abolishing the role of capital…

  6. Openers for Biology Classes.

    Science.gov (United States)

    Gridley, C. Robert R.

    This teaching guide contains 200 activities that are suitable for openers and demonstrations in biology classes. Details are provided regarding the use of these activities. Some of the broad topics under which the activities are organized include algae, amphibians, bacteria, biologists, crustaceans, dinosaurs, ecology, evolution, flowering plants,…

  7. Communication, "Class," and Culture.

    Science.gov (United States)

    Jeffres, Leo W.

    A study was conducted to examine the relationships among communication, social class, and ethnic heritage. Eleven of thirteen ethnic groups in a Midwestern metropolitan area who had been studied in 1976 were surveyed again in late 1980 and early 1981. Groups surveyed were Irish, Greek, Czech, Italian, Lebanese, Hungarian, Lithuanian, Polish,…

  8. Shrinking Your Class

    Science.gov (United States)

    Herron-Thorpe, Farren L.; Olson, Jo Clay; Davis, Denny

    2010-01-01

    Toys in the classroom was the result of a National Science Foundation grant that brought two engineering graduate students to a middle school math class. The graduate students and teachers collaborated in an effort to enhance students' mathematical learning. An engineering context was theorized as a way to further develop students' understanding…

  9. IQ and Social Class.

    Science.gov (United States)

    Fischbein, Siv

    1980-01-01

    Swedish longitudinal studies of twins support Scarr-Salapatek's explanation of nature-nurture influences on intelligence. This model predicts more genetic variance in test results for advantaged than disadvantaged groups. Jensen's work, however, suggests equal amounts of variance among different social classes. (Author/CP)

  10. Coincidence classes in nonorientable manifolds

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available We study Nielsen coincidence theory for maps between manifolds of same dimension regardless of orientation. We use the definition of semi-index of a class, review the definition of defective classes, and study the occurrence of defective root classes. We prove a semi-index product formula for lifting maps and give conditions for the defective coincidence classes to be the only essential classes.

  11. World Class Facilities Management

    DEFF Research Database (Denmark)

    Malmstrøm, Ole Emil; Jensen, Per Anker

    2013-01-01

    Alle der med entusiasme arbejder med Facilities Management drømmer om at levere World Class. DFM drømmer om at skabe rammer og baggrund for, at vi i Danmark kan bryste os at være blandt de førende på verdensplan. Her samles op på, hvor tæt vi er på at nå drømmemålet.......Alle der med entusiasme arbejder med Facilities Management drømmer om at levere World Class. DFM drømmer om at skabe rammer og baggrund for, at vi i Danmark kan bryste os at være blandt de førende på verdensplan. Her samles op på, hvor tæt vi er på at nå drømmemålet....

  12. Out about class.

    Science.gov (United States)

    Walker, L; Sell, I

    2001-01-01

    ABSTRACT Lesbian activist Léonie Walker traces the evolution of her involvement in social change philanthropy and her work to bring together activists of diverse class and racial backgrounds. She shows how she was trained as an activist, discusses conscious and socially responsible ways to steward wealth, and gives voice to the seldom-heard experiences of LGBT people with inherited wealth. The co-founder of the Women Managing Wealth program at the Ms. Foundation and a board member of Astraea Lesbian Action Foundation, she has also developed and facilitated numerous Dismantling Classism workshops. In this article, she discusses the importance of, and ways of implementing, cross-class, cross-race dialogue that can further understanding among activists of different backgrounds.

  13. Flexible Word Classes

    DEFF Research Database (Denmark)

    2013-01-01

    a century, the phenomenon has not played a role in the development of linguistic typology or modern grammatical theory. The current volume aims to address this gap by offering detailed studies on flexible word classes, investigating their properties and what it means for the grammar of a language to have...... Indonesian, Santali, Sri Lanka Malay, Lushootseed, Gooniyandi, and Late Archaic Chinese. Readership: Linguists and students of linguistics and cognitive sciences, anthropologists, philosophers...

  14. [Social classes and poverty].

    Science.gov (United States)

    Benach, Joan; Amable, Marcelo

    2004-05-01

    Social classes and poverty are two key social determinants fundamental to understand how disease and health inequalities are produced. During the 90's in Spain there has been a notable oscillation in the inequality and poverty levels, with an increase in the middle of the decade when new forms of social exclusion, high levels of unemployment and great difficulties in accessing the labour market, especially for those workers with less resources, emerged. Today society is still characterized by a clear social stratification and the existence of social classes with a predominance of high levels of unemployment and precarious jobs, and where poverty is an endemic social problem much worse than the EU average. To diminish health inequalities and to improve the quality of life will depend very much on the reduction of the poverty levels and the improvement of equal opportunities and quality of employment. To increase understanding of how social class and poverty affect public health, there is a need to improve the quality of both information and research, and furthermore planners and political decision makers must take into account those determinants when undertaking disease prevention and health promotion.

  15. Class Action and Class Settlement in a European Perspective

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2013-01-01

    The article analyses the options for introducing common European rules on class action lawsuits with an opt-out-model in individual cases. An analysis is made of how the risks of misuse of class actions can be prevented. The article considers the Dutch rules on class settlements (the WCAM procedure...

  16. Anomalia de Classe III

    OpenAIRE

    2014-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária Introdução: A anomalia de classe III, é uma má oclusão que afeta os indivíduos psicologicamente, pois hoje em dia, a estética é socialmente valorizada. Deste modo, o diagnóstico deve ser executado precocemente para que os indivíduos portadores desta anomalia, possam ser acompanhados desde criança, pelos profissionais área da Medicina...

  17. Reconciling Virtual Classes with Genericity

    DEFF Research Database (Denmark)

    Ernst, Erik

    2006-01-01

    classes. As a result, a kind of type parameters have been introduced, but they are simple and only used where they excel. Conversely, final definitions of virtual classes have been re- moved from the language, thus making virtual classes more flexible. The result- ing language presents a clearer and more...

  18. Team Learning in Large Classes.

    Science.gov (United States)

    Roueche, Suanne D., Ed.

    1984-01-01

    Information and suggestions are provided on the use of team learning in large college classes. Introductory material discusses the negative cycle of student-teacher interaction that may be provoked by large classes, and the use of permanent, heterogeneous, six- or seven-member student learning groups as the central focus of class activity as a…

  19. Understanding Class in Contemporary Societies

    DEFF Research Database (Denmark)

    Harrits, Gitte Sommer

    2007-01-01

    In this paper, I argue that claims about the death of class and the coming of the classless society are premature. Such claims are seldom genuinely empirical, and the theoretical argument often refers to a simple and therefore easily dismissible concept of class. By rejecting the concept of class...

  20. Hirzebruch classes of complex hypersurfaces

    CERN Document Server

    Cappell, Sylvain E; Schuermann, Joerg; Shaneson, Julius L

    2009-01-01

    The Milnor-Hirzebruch class of a locally complete intersection X in an algebraic manifold M measures the difference between the (Poincare dual of the) Hirzebruch class of the virtual tangent bundle of X and, respectively, the Brasselet-Schuermann-Yokura (homology) Hirzebruch class of X. In this note, we calculate the Milnor-Hirzebruch class of a globally defined algebraic hypersurface X in terms of the corresponding Hirzebruch invariants of singular strata in a Whitney stratification of X. Our approach is based on Schuermann's specialization property for the motivic Hirzebruch class transformation of Brasselet-Schuermann-Yokura.

  1. Class Discovery in Galaxy Classification

    CERN Document Server

    Bazell, D; Bazell, David; Miller, David J.

    2004-01-01

    In recent years, automated, supervised classification techniques have been fruitfully applied to labeling and organizing large astronomical databases. These methods require off-line classifier training, based on labeled examples from each of the (known) object classes. In practice, only a small batch of labeled examples, hand-labeled by a human expert, may be available for training. Moreover, there may be no labeled examples for some classes present in the data, i.e. the database may contain several unknown classes. Unknown classes may be present due to 1) uncertainty in or lack of knowledge of the measurement process, 2) an inability to adequately ``survey'' a massive database to assess its content (classes), and/or 3) an incomplete scientific hypothesis. In recent work, new class discovery in mixed labeled/unlabeled data was formally posed, with a proposed solution based on mixture models. In this work we investigate this approach, propose a competing technique suitable for class discovery in neural network...

  2. Propagating Class and Method Combination

    DEFF Research Database (Denmark)

    Ernst, Erik

    1999-01-01

    This paper presents a mixin based class and method combination mechanism with block structure propagation. Traditionally, mixins can be composed to form new classes, possibly merging the implementations of methods (as in CLOS). In our approach, a class or method combination operation may cause any...... number of implicit combinations. For example, it is possible to specify separate aspects of a family of classes, and then combine several aspects into a full-fledged class family. The combination expressions would explicitly combine whole-family aspects, and by propagation implicitly combine the aspects...... for each member of the class family, and again by propagation implicitly compose each method from its aspects. As opposed to CLOS, this is type-checked statically; and as opposed to other systems for advanced class combination/ merging/weaving, it is integrated directly in the language, ensuring a clear...

  3. Pseudo Class III malocclusion.

    Science.gov (United States)

    Al-Hummayani, Fadia M

    2016-04-01

    The treatment of deep anterior crossbite is technically challenging due to the difficulty of placing traditional brackets with fixed appliances. This case report represents a none traditional treatment modality to treat deep anterior crossbite in an adult pseudo class III malocclusion complicated by severely retruded, supraerupted upper and lower incisors. Treatment was carried out in 2 phases. Phase I treatment was performed by removable appliance "modified Hawley appliance with inverted labial bow," some modifications were carried out to it to suit the presented case. Positive overbite and overjet was accomplished in one month, in this phase with minimal forces exerted on the lower incisors. Whereas, phase II treatment was performed with fixed appliances (braces) to align teeth and have proper over bite and overjet and to close posterior open bite, this phase was accomplished within 11 month.

  4. Network class superposition analyses.

    Directory of Open Access Journals (Sweden)

    Carl A B Pearson

    Full Text Available Networks are often used to understand a whole system by modeling the interactions among its pieces. Examples include biomolecules in a cell interacting to provide some primary function, or species in an environment forming a stable community. However, these interactions are often unknown; instead, the pieces' dynamic states are known, and network structure must be inferred. Because observed function may be explained by many different networks (e.g., ≈ 10(30 for the yeast cell cycle process, considering dynamics beyond this primary function means picking a single network or suitable sample: measuring over all networks exhibiting the primary function is computationally infeasible. We circumvent that obstacle by calculating the network class ensemble. We represent the ensemble by a stochastic matrix T, which is a transition-by-transition superposition of the system dynamics for each member of the class. We present concrete results for T derived from boolean time series dynamics on networks obeying the Strong Inhibition rule, by applying T to several traditional questions about network dynamics. We show that the distribution of the number of point attractors can be accurately estimated with T. We show how to generate Derrida plots based on T. We show that T-based Shannon entropy outperforms other methods at selecting experiments to further narrow the network structure. We also outline an experimental test of predictions based on T. We motivate all of these results in terms of a popular molecular biology boolean network model for the yeast cell cycle, but the methods and analyses we introduce are general. We conclude with open questions for T, for example, application to other models, computational considerations when scaling up to larger systems, and other potential analyses.

  5. Organizing MHC Class II Presentation

    Directory of Open Access Journals (Sweden)

    David R Fooksman

    2014-04-01

    Full Text Available Major histocompatibility complex (MHC class II molecules are ligands for CD4+ T cells and are critical for initiating the adaptive immune response. This review is focused on what is currently known about MHC class II organization at the plasma membrane of antigen presenting cells and how this affects antigen presentation to T cells. The organization and diffusion of class II molecules have been measured by a variety of biochemical and microscopic techniques. Membrane lipids and other proteins have been implicated in MHC class II organization and function. However, when compared with the organization of MHC class I or TCR complexes, much less is known about MHC class II. Since clustering of T cell receptors occurs during activation, the organization of MHC molecules prior to recognition and during synapse formation may be critical for antigen presentation.

  6. Merging separately established stimulus classes with outcome-specific reinforcement.

    Science.gov (United States)

    Johnson, Cammarie; Meleshkevich, Olga; Dube, William V

    2014-01-01

    This study extended previous research on equivalence relations established with outcome-specific reinforcers to include the merger of separately established stimulus classes. Participants were four adults. Conditional discriminations AC and BC were trained first. Correct selections of C1 (C2, or C3) in the presence of A1 or B1 (A2 or B2, or A3 or B3) were followed by red (blue, or white) tokens; tokens were exchanged for value added to three participant-selected gift cards. Outcomes on equivalence tests for three-member classes ABC were positive. DF and EF were trained with the same reinforcing consequences, and tests were positive for three-member classes DEF. Results of class merger tests with combinations of stimuli from the ABC and DEF classes (AD, FB, etc.) were immediately positive for two participants, demonstrating six-member classes ABCDEF with reinforcers as nodes. Merger tests for a third participant were initially negative but became positive after brief exposure to unreinforced probe trials with reinforcers as comparison stimuli. Following class merger, tests for matching the reinforcers to samples and comparisons were also positive. Class-merger test results were negative for a fourth participant. The results provide the first demonstration of eight-member equivalence classes including two outcome-specific conditioned reinforcing stimuli.

  7. Weil classes on abelian varieties

    CERN Document Server

    Moonen, B J J; Zarhin, Yu. G.

    1996-01-01

    Consider a complex abelian variety X on which a field F acts. Generalizing a construction of A. Weil, one associates to this a subspace W_F of the cohomology of X, which we call the space of Weil classes w.r.t. F. The purpose of this paper is to answer the following two questions: Q1: under what conditions on F does the space W_F contain, or even consist of, Hodge classes?, Q2: if W_F contains Hodge classes, under what conditions on F are these exceptional? In case X is defined over a number field, we also answer the analogous questions for Tate classes.

  8. On uniqueness of characteristic classes

    DEFF Research Database (Denmark)

    Feliu, Elisenda

    2011-01-01

    We give an axiomatic characterization of maps from algebraic K-theory. The results apply to a large class of maps from algebraic K-theory to any suitable cohomology theory or to algebraic K-theory. In particular, we obtain comparison theorems for the Chern character and Chern classes and for the ......We give an axiomatic characterization of maps from algebraic K-theory. The results apply to a large class of maps from algebraic K-theory to any suitable cohomology theory or to algebraic K-theory. In particular, we obtain comparison theorems for the Chern character and Chern classes...

  9. Type Families with Class, Type Classes with Family

    DEFF Research Database (Denmark)

    Serrano, Alejandro; Hage, Jurriaan; Bahr, Patrick

    2015-01-01

    Type classes and type families are key ingredients in Haskell programming. Type classes were introduced to deal with ad-hoc polymorphism, although with the introduction of functional dependencies, their use expanded to type-level programming. Type families also allow encoding type-level functions...

  10. Wealth and the inflated self: class, entitlement, and narcissism.

    Science.gov (United States)

    Piff, Paul K

    2014-01-01

    Americans may be more narcissistic now than ever, but narcissism is not evenly distributed across social strata. Five studies demonstrated that higher social class is associated with increased entitlement and narcissism. Upper-class individuals reported greater psychological entitlement (Studies 1a, 1b, and 2) and narcissistic personality tendencies (Study 2), and they were more likely to behave in a narcissistic fashion by opting to look at themselves in a mirror (Study 3). Finally, inducing egalitarian values in upper-class participants decreased their narcissism to a level on par with their lower-class peers (Study 4). These findings offer novel evidence regarding the influence of social class on the self and highlight the importance of social stratification to understanding basic psychological processes.

  11. Condylar volume and condylar area in class I, class II and class III young adult subjects

    OpenAIRE

    Saccucci Matteo; D’Attilio Michele; Rodolfino Daria; Festa Felice; Polimeni Antonella; Tecco Simona

    2012-01-01

    Abstract Aim Aim of this study was to compare the volume and the shape of mandibular condyles in a Caucasian young adult population, with different skeletal pattern. Material and methods 200 Caucasian patients (15–30 years old, 95 male and 105 females) were classified in three groups on the base of ANB angle: skeletal class I (65 patients), skeletal class II (70 patients) and skeletal class III (65 patients). Left and right TMJs of each subject were evaluated independently with CBCT (Iluma). ...

  12. Making Large Classes More Interactive.

    Science.gov (United States)

    Brenner, John

    2000-01-01

    Describes the method of using prompts to allow students to have more "voice" in a large class. The prompt assignment requires students to respond anonymously to a statement that concerns the chapter being discussed in the class. Discusses how the Internet has allowed more freedom with the prompts. Puts forth some student responses to the…

  13. Student Engagement and Marketing Classes

    Science.gov (United States)

    Taylor, Steven A.; Hunter, Gary L.; Melton, Horace; Goodwin, Stephen A.

    2011-01-01

    A study is reported that investigates the goals underlying undergraduate students' engagement in their major classes, nonmajor classes, and in extracurricular activities. The qualitative study employs both focus groups and goal-mapping exercises. The results suggest that students tend to focus on utilitarian, attribute-level considerations mainly…

  14. Notes on absolute Hodge classes

    CERN Document Server

    Charles, François

    2011-01-01

    We survey the theory of absolute Hodge classes. The notes include a full proof of Deligne's theorem on absolute Hodge classes on abelian varieties as well as a discussion of other topics, such as the field of definition of Hodge loci and the Kuga-Satake construction.

  15. Predicting Acoustics in Class Rooms

    DEFF Research Database (Denmark)

    Christensen, Claus Lynge; Rindel, Jens Holger

    2005-01-01

    Typical class rooms have fairly simple geometries, even so room acoustics in this type of room is difficult to predict using today's room acoustic computer modeling software. The reasons why acoustics of class rooms are harder to predict than acoustics of complicated concert halls might...

  16. The Paradox of Paperless Classes.

    Science.gov (United States)

    Lackie, Paula

    1998-01-01

    Describes paperless classes developed at Carleton College that augment traditional classes by giving students and faculty the ability to share digital course-related materials via the campus computer network. Presents a case study of a managerial economics course, and includes problems with various aspects of the course and solutions. (LRW)

  17. Translanguaging in a Reading Class

    Science.gov (United States)

    Vaish, Viniti; Subhan, Aidil

    2015-01-01

    Using translanguaging as a theoretical foundation, this paper analyses findings from a Grade 2 reading class for low achieving students, where Malay was used as a scaffold to teach English. Data come from one class in one school in Singapore and its Learning Support Programme (LSP), which is part of a larger research project on biliteracy. The LSP…

  18. Class, Identity, and Teacher Education

    Science.gov (United States)

    Van Galen, Jane A.

    2010-01-01

    This paper explores the possibilities of working with White, working-class teacher education students to explore the "complex social trajectory" (Reay in Women's Stud Int Forum 20(2):225-233, 1997a, p. 19) of class border crossing as they progress through college. Through analysis of a course that I have developed, "Education and the American…

  19. Class Differences in Cohabitation Processes

    Science.gov (United States)

    Sassler, Sharon; Miller, Amanda J.

    2011-01-01

    Despite the burgeoning cohabitation literature, research has failed to examine social class variation in processes of forming and advancing such unions. Drawing upon in-depth interviews with 122 working- and middle-class cohabitors, we examine the duration between dating and moving in together, reasons for cohabiting, and subsequent plans.…

  20. Ideas for Managing Large Classes.

    Science.gov (United States)

    Kabel, Robert L.

    1983-01-01

    Describes management strategies used in a large kinetics/industrial chemistry course. Strategies are designed to make instruction in such classes more efficient and effective. Areas addressed include homework assignment, quizzes, final examination, grading and feedback, and rewards for conducting the class in the manner described. (JN)

  1. Relations among tautological classes revisited

    DEFF Research Database (Denmark)

    Randal-Williams, Oscar

    2012-01-01

    We give a simple generalisation of a theorem of Morita (1989) [10] and [11], which leads to a great number of relations among tautological classes on moduli spaces of Riemann surfaces......We give a simple generalisation of a theorem of Morita (1989) [10] and [11], which leads to a great number of relations among tautological classes on moduli spaces of Riemann surfaces...

  2. Tautological Classes on Projective Towers

    CERN Document Server

    Negut, Andrei

    2011-01-01

    When one has a tower of projective bundles over an algebraic variety and wishes to compute the push-forward of any cohomology class down this tower, one needs to recursively compute the Segre classes corresponding to each level. In this paper, we give a closed combinatorial formula that encodes this recursive procedure.

  3. Control Class Summaries and Control Class IV from April 1990

    Energy Technology Data Exchange (ETDEWEB)

    Wu, J.; /Fermilab

    1991-02-22

    The D0 cryogenic control system is a complicated system with many facets. Because of the large number and variety of features in the system, a series of ongoing control system training seminars, or control classes, were created in order to keep people up to date on the operation of the system. As of the writing of this engineering note, there have been four classes. The original lecture notes from each class can be found in the cryogenic control room at the D0 Assembly Building, or in the Co-op office. This note provides a summary of the first three control classes, and it includes the entire set of notes from the fourth class, which was held in April of 1990. This class was taught by Jeff Wendlandt and Dan Markley. Dan should be consulted for more complete explanations than those given in the notes. The notes are, in fact, more of a reference for someone who has some experience with the system, than they are a training manual. Most of the pages include pictures and printouts of different menus and functions, useful for finding details without searching through the actual program. In general, this note serves as a pointer to the existence of the control class lecture notes, and as an explanation of their overall contents and purpose.

  4. Lipschitz classes on local fields

    Institute of Scientific and Technical Information of China (English)

    Wei-yi SU; Guo-xiang CHEN

    2007-01-01

    The Lipschitz class Lipα on a local field K is defined in this note, and the equivalent relationship between the Lipschitz class Lipα and the Holder type space Cα (K) is proved. Then, those important characteristics on the Euclidean space Rn and the local field K are compared, so that one may interpret the essential differences between the analyses on Rn and K. Finally, the Cantor type fractal function (V)(x) is showed in the Lipschitz class Lip (m, K), m < ln2/ln3.

  5. Lipschitz classes on local fields

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The Lipschitz class Lipαon a local field K is defined in this note,and the equivalent relationship between the Lipschitz class Lipαand the Holder type space C~α(K)is proved.Then,those important characteristics on the Euclidean space R~n and the local field K are compared,so that one may interpret the essential differences between the analyses on R~n and K.Finally,the Cantor type fractal functionθ(x)is showed in the Lipschitz class Lip(m,K),m<(ln 2/ln 3).

  6. New Ramsey Classes from Old

    CERN Document Server

    Bodirsky, Manuel

    2012-01-01

    Let C_1 and C_2 be strong amalgamation classes of finite structures, with disjoint finite signatures sigma and tau. Then C_1 wedge C_2 denotes the class of all finite (sigma cup tau)-structures whose sigma-reduct is from C_1 and whose tau-reduct is from C_2. We prove that when C_1 and C_2 are Ramsey, then C_1 wedge C_2 is also Ramsey. We also discuss variations of this statement, and give several examples of new Ramsey classes derived from those general results.

  7. Homogeneous products of conjugacy classes

    OpenAIRE

    Adan-Bante, Edith

    2006-01-01

    Let $G$ be a finite group and $a\\in G$. Let $a^G=\\{g^{-1}ag\\mid g\\in G\\}$ be the conjugacy class of $a$ in $G$. Assume that $a^G$ and $b^G$ are conjugacy classes of $G$ with the property that ${\\bf C}_G(a)={\\bf C}_G(b)$. Then $a^G b^G$ is a conjugacy class if and only if $[a,G]=[b,G]=[ab,G]$ and $[ab,G]$ is a normal subgroup of $G$.

  8. The Relationship between Class I and Class II Methanol Masers

    CERN Document Server

    Ellingsen, S P

    2005-01-01

    The Australia Telescope National Facility Mopra millimetre telescope has been used to search for 95.1-GHz class I methanol masers towards sixty-two 6.6-GHz class II methanol masers. A total of twenty-six 95.1-GHz masers were detected, eighteen of these being new discoveries. Combining the results of this search with observations reported in the literature, a near complete sample of sixty-six 6.6-GHz class II methanol masers has been searched in the 95.1-GHz transition, with detections towards 38 per cent (twenty-five detections ; not all of the sources studied in this paper qualify for the complete sample, and some of the sources in the sample were not observed in the present observations). There is no evidence of an anti-correlation between either the velocity range, or peak flux density of the class I and II transitions, contrary to suggestions from previous studies. The majority of class I methanol maser sources have a velocity range that partially overlaps with the class II maser transitions. The presence...

  9. Management of Classes with Breaches of Discipline

    Institute of Scientific and Technical Information of China (English)

    陈海军

    2009-01-01

    As an only child is pampered and spoiled by parents, the contemporary student easily breaches class discipline. Class management appears more concerned than ever because breaches of class discipline have great impact on teaching. The author clarifies the necessity to study the management of classes with breaches of class discipline, numerates the phenomena of breaches of class discipline, precisely analyzes the causes from teachers and students and especially submits several measures to effectively prevent breaches of class discipline.

  10. Research on the use of E-Class in the university class management

    Institute of Scientific and Technical Information of China (English)

    LIANG QIN; LAI YI WEI

    2016-01-01

    As an information exchange platform for online class, E-Class has played an important role in class management since its foundation. Based on the analysis of the impact of the network to university class management, this paper studied the advantages and the disadvantages of the current E-Class in class management, and proposed suggestions of strengthening the E-Class management.

  11. Biochemical Characterization of SFC-1, a class A carbapenem-hydrolyzing beta-lactamase.

    Science.gov (United States)

    Fonseca, Fátima; Sarmento, Ana Cristina; Henriques, Isabel; Samyn, Bart; van Beeumen, Jozef; Domingues, Pedro; Domingues, Maria Rosário; Saavedra, Maria José; Correia, António

    2007-12-01

    The carbapenem-hydrolyzing beta-lactamase SFC-1 from Serratia fonticola UTAD54 was overexpressed in Escherichia coli, purified, and characterized. The enzyme exhibited an apparent molecular mass of 30.5 kDa, determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. SFC-1 hydrolyzes penicillins, cephalosporins, aztreonam, and carbapenems and is inhibited by clavulanic acid, sulbactam, and tazobactam.

  12. Biochemical Characterization of SFC-1, a Class A Carbapenem-Hydrolyzing β-Lactamase▿

    Science.gov (United States)

    Fonseca, Fátima; Sarmento, Ana Cristina; Henriques, Isabel; Samyn, Bart; van Beeumen, Jozef; Domingues, Pedro; Domingues, Maria Rosário; Saavedra, Maria José; Correia, António

    2007-01-01

    The carbapenem-hydrolyzing β-lactamase SFC-1 from Serratia fonticola UTAD54 was overexpressed in Escherichia coli, purified, and characterized. The enzyme exhibited an apparent molecular mass of 30.5 kDa, determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. SFC-1 hydrolyzes penicillins, cephalosporins, aztreonam, and carbapenems and is inhibited by clavulanic acid, sulbactam, and tazobactam. PMID:17875998

  13. USING PICTURES IN ENGLISH CLASSES

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Introduction In China, some English teachers go to class with only a textbook and a teaching plan, nothing else. After a while, the students complain that their classes are becoming more and more boring. Teachers have tried many ways to make their classes more interesting, motivating and effective, but using pictures in the classroom to do this has not been a popular method. The world provides us with all kinds of beautiful pictures. There is no reason why we should not make better use of them in language learning and teaching. This article will discuss the reasons for using pictures, suggest ways of collecting pictures and ways of using pictures in reading, writing, listening and speaking classes.

  14. Condylar volume and condylar area in class I, class II and class III young adult subjects

    Directory of Open Access Journals (Sweden)

    Saccucci Matteo

    2012-12-01

    Full Text Available Abstract Aim Aim of this study was to compare the volume and the shape of mandibular condyles in a Caucasian young adult population, with different skeletal pattern. Material and methods 200 Caucasian patients (15–30 years old, 95 male and 105 females were classified in three groups on the base of ANB angle: skeletal class I (65 patients, skeletal class II (70 patients and skeletal class III (65 patients. Left and right TMJs of each subject were evaluated independently with CBCT (Iluma. TMJ evaluation included: condylar volume; condylar area; morphological index (MI. Condylar volumes were calculated by using the Mimics software. The condylar volume, the area and the morphological index (MI were compared among the three groups, by using non-parametric tests. Results The Kruskal-Wallis test and the Mann Whitney test revealed that: no significant difference was observed in the whole sample between the right and the left condylar volume; subjects in skeletal class III showed a significantly higher condylar volume, respect to class I and class II subjects (p 3 in males and 663.5 ± 81.3 mm3 in females; p 2 in males and 389.76 ± 61.15 mm2 in females; p  Conclusion Skeletal class appeared to be associated to the mandibular condylar volume and to the mandibular condylar area in the Caucasian orthodontic population.

  15. Perceptual qualities and material classes.

    Science.gov (United States)

    Fleming, Roland W; Wiebel, Christiane; Gegenfurtner, Karl

    2013-07-11

    Under typical viewing conditions, we can easily group materials into distinct classes (e.g., woods, plastics, textiles). Additionally, we can also make many other judgments about material properties (e.g., hardness, rigidity, colorfulness). Although these two types of judgment (classification and inferring material properties) have different requirements, they likely facilitate one another. We conducted two experiments to investigate the interactions between material classification and judgments of material qualities in both the visual and semantic domains. In Experiment 1, nine students viewed 130 images of materials from 10 different classes. For each image, they rated nine subjective properties (glossiness, transparency, colorfulness, roughness, hardness, coldness, fragility, naturalness, prettiness). In Experiment 2, 65 subjects were given the verbal names of six material classes, which they rated in terms of 42 adjectives describing material qualities. In both experiments, there was notable agreement between subjects, and a relatively small number of factors (weighted combinations of different qualities) were substantially independent of one another. Despite the difficulty of classifying materials from images (Liu, Sharan, Adelson, & Rosenholtz, 2010), the different classes were well clustered in the feature space defined by the subjective ratings. K-means clustering could correctly identify class membership for over 90% of the samples, based on the average ratings across subjects. We also found a high degree of consistency between the two tasks, suggesting subjects access similar information about materials whether judging their qualities visually or from memory. Together, these findings show that perceptual qualities are well defined, distinct, and systematically related to material class membership.

  16. Main: PYRIMIDINEBOXOSRAMY1A [PLACE

    Lifescience Database Archive (English)

    Full Text Available PYRIMIDINEBOXOSRAMY1A S000259 19-August-2004 (last modified) kehi Pyrimidine box fo...und in rice (O.s.) alpha-amylase (RAmy1A) gene; Gibberellin-respons cis-element of GARE and pyrimidine box a...ically to this site; See S000265; alpha-amylase; sugar repression; GARE; pyrimidine box; feed-back metabolic

  17. Reference: PYRIMIDINEBOXOSRAMY1A [PLACE

    Lifescience Database Archive (English)

    Full Text Available PYRIMIDINEBOXOSRAMY1A Morita A, Umemura T, Kuroyanagi M, Futsuhara Y, Perata P, Yamaguchi J Functional disse...ction of a sugar-repressed alpha-amylase gene (Ramy1A) promoter in rice embryos FEBS Lett 423:81-85 (1998) PubMed: 9506846; ...

  18. Classes subalternas, lutas de classe e hegemonia: uma abordagem gramsciana Subaltern classes, class struggles and hegemony: a gramscian approach

    Directory of Open Access Journals (Sweden)

    Ivete Simionatto

    2009-06-01

    Full Text Available O artigo procura resgatar, no pensamento de Antonio Gramsci, a concepção de classes subalternas e a sua relação com outras categorias, especialmente, o Estado, a sociedade civil e a hegemonia, como suportes da luta de classes na realidade contemporânea. Aborda, ainda, as relações entre classes subalternas, senso comum e ideologia, bem como as formas de superação tematizadas por Gramsci, através da cultura e da filosofia da práxis. Nesse sentido, num movimento de totalidade, busca recuperar a discussão das classes subalternas, a partir da original formulação gramsciana no âmbito do marxismo, mediante a interação dialética entre estrutura e superestrutura, economia e política. Além do resgate conceitual, apontam-se alguns elementos como subsídios à discussão das formas de subalternidade presentes na realidade contemporânea e as possibilidades de fortalecimento das lutas de tais camadas de classe, sobretudo em momentos de forte desmobilização da participação popular.This article sought to revive the concept of subaltern classes and their relation with other categories, particularly the State, civil society and hegemony in the thinking of Antonio Gramsci, as a support for contemporary class struggles. It also analyzes the relations between subaltern classes, common sense and ideology, as well as the forms of "overcoming" conceptualized by Gramsci, through the culture and philosophy of praxis. The paper revives the discussion of the subaltern classes, based on the original Gramscian formulation in the realm of Marxism, through the dialectic interaction between structure and superstructure, economy and politics. In addition to the conceptual revival, it indicates some elements that can support the discussion of the forms of subalternity found in contemporary reality and the possibilities for strengthening the struggles of these class layers, above all in moments of strong demobilization of popular participation.

  19. Main: WBOXGACAD1A [PLACE

    Lifescience Database Archive (English)

    Full Text Available WBOXGACAD1A S000448 19-August-2004 (last modified) kehi W-box found in the promoter region of the CAD...GAC), S000142 (TTGACC); W-box; TGAC; CAD; WRKY; Gossypium arboreum (cotton) AGTCAAAATTGACC ...

  20. Using Alternative Assessments in Business and Foreign Language Classes

    Science.gov (United States)

    Gill, Deborah; Lucas, Diane

    2013-01-01

    The present study will be divided in three parts: (1) a discussion of authentic alternative assessments vs. traditional assessments in language and business classes; (2) an explanation on how to create authentic alternative assessments using technology-based and non-technology-based materials; and (3) tools to evaluate these authentic assessments.…

  1. 47 CFR 74.708 - Class A TV and digital Class A TV station protection.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Class A TV and digital Class A TV station... SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.708 Class A TV and digital Class A TV station protection. (a) The Class A TV and digital Class A TV station protected contours are specified...

  2. Improved water quality retrieval by identifying optically unique water classes

    Science.gov (United States)

    Nazeer, Majid; Nichol, Janet E.

    2016-10-01

    Accurate remote sensing retrieval of water quality parameters in complex coastal environments is challenging due to variability of the coastal environment. For example, in the coastal waters of Hong Kong water quality varies from east to west. The currently existing water zones, defined by the Hong Kong Environmental Protection Department (EPD) are based on ease of access to sampling locations rather than on water quality alone. In this study an archive of fifty-seven Landsat Thematic Mapper (TM), Enhanced Thematic Mapper Plus (ETM+) and HJ-1 A/B Charged Couple Device (CCD) images over a 13-year period (January 2000-December 2012) was used to define optically distinct water classes by Fuzzy c-Means (FCM) clustering. The clustering was applied by combining the Surface Reflectance (SR) derived from the first four bands of Landsat and HJ-1 scenes with 240 insitu samples of Chlorophyll-a (Chl-a) and Suspended Solid (SS) concentrations collected within 2 h of image acquisition. The FCM clustering suggested the existence of five optically different water classes in the region. The significance of the defined water classes was tested in terms of the water SR behaviour in each band. The SR for Classes 1 and 2 in bands 1-3 was lower than in other classes, and band 4 showed the lowest reflectance, indicating that these classes represent a clearer type of water. Class 3 showed intermediate reflectance in all bands, while Classes 4 and 5 showed overall higher reflectance indicating high sediment contribution from the Pearl River Delta. Application of water quality retrievals within individual classes showed much greater confidence with Root Mean Square Error (RMSE) of 1.32 μg/l (1.21 mg/l) for Chl-a (SS) concentrations, compared with 5.97 μg/l (2.98 mg/l) when applied to the whole spectrum of different water types across the region.

  3. Enzymatic Browning: a practical class

    Directory of Open Access Journals (Sweden)

    Maria Teresa Pedrosa Silva Clerici

    2014-10-01

    Full Text Available This paper presents a practical class about the enzymes polyphenol oxidases, which have been shown to be responsible for the enzymatic browning of fruits and vegetables. Vegetables samples were submitted to enzymatic inactivation process with chemical reagents, as well as by bleaching methods of applying heat by conventional oven and microwave oven. Process efficiency was assessed qualitatively by both observing the guaiacol peroxidase activity and after the storage period under refrigeration or freezing. The practical results obtained in this class allow exploring multidisciplinary knowledge in food science, with practical applications in everyday life.

  4. Teaching Reading in Large Classes

    Directory of Open Access Journals (Sweden)

    Rojas B Leyla María

    2001-08-01

    Full Text Available This article deals with the problem of overcrowded classes. Ideas from research findings are given in an attempt to approach the teaching of reading at tertiary and secondary levels. This study is mainly based on the analysis of five pedagogical principles that emerged from the Lancaster-Leeds Language Learning in Large Classes Research Project in the United Kingdom (1986- 1999. Emphasis is also made on two important general principles emerging from the project: being realistic and giving more responsibility to the learner. Practical suggestions from research on reading are made based on the principles stated.

  5. Moran sets and Moran classes

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The purpose of this survey is to present Moran sets and Moran classes which generalize the classical selfsimilar sets from the following points: ( i ) The placements of the basic sets at each step of the constructions can be arbitrary; (ii) the contraction ratios may be different at each step; and (iii) the lower limit of the contraction ratios permits zero. In this discussion we will present geometrical properties and results of dimensions of these sets and classes,and discuss conformal Moran sets and random Moran sets as well.``

  6. Supervised Object Class Colour Normalisation

    DEFF Research Database (Denmark)

    Riabchenko, Ekatarina; Lankinen, Jukka; Buch, Anders Glent;

    2013-01-01

    Colour is an important cue in many applications of computer vision and image processing, but robust usage often requires estimation of the unknown illuminant colour. Usually, to obtain images invariant to the illumination conditions under which they were taken, color normalisation is used....... In this work, we develop a such colour normalisation technique, where true colours are not important per se but where examples of same classes have photometrically consistent appearance. This is achieved by supervised estimation of a class specic canonical colour space where the examples have minimal variation...

  7. Two classes of metric spaces

    Directory of Open Access Journals (Sweden)

    Isabel Garrido

    2016-04-01

    Full Text Available The class of metric spaces (X,d known as small-determined spaces, introduced by Garrido and Jaramillo, are properly defined by means of some type of real-valued Lipschitz functions on X. On the other hand, B-simple metric spaces introduced by Hejcman are defined in terms of some kind of bornologies of bounded subsets of X. In this note we present a common framework where both classes of metric spaces can be studied which allows us to see not only the relationships between them but also to obtain new internal characterizations of these metric properties.

  8. Civility in Classes and Sports

    Science.gov (United States)

    Lumpkin, Angela

    2010-01-01

    Civility is a polite or courteous act, expression, or standard of conduct, including the display of respect and tolerance to everyone. Teaching and modeling civility in classes and with sport teams is essential so students and athletes can learn the importance of and demonstrate civility in their interactions with others. Teachers and coaches…

  9. A Class of Graceful Trees

    Institute of Scientific and Technical Information of China (English)

    孟凡洪; 苏耕; 杨继

    2000-01-01

    The present paper shows the coordinates of a tree and its vertices, defines a kind of Trees with Odd-Number Radiant Type (TONRT), deals with the gracefulness of TONRT by using the edge-moving theorem, and uses graceful TONRT to construct another class of graceful trees.

  10. A Touch of...Class.

    Science.gov (United States)

    Courtel, Claudine, Ed.; Amyot, Denise, Ed.

    1985-01-01

    A series of class activities for French instruction includes uses of the telephone book, tape recordings, advertising, word and pattern games, and creation of a radio program. Suggestions for instruction of Canadian natives include games for animal, body, and clothing vocabulary. (MSE)

  11. Art of Class Teaching Encourage

    Institute of Scientific and Technical Information of China (English)

    HE Jiao-fei

    2013-01-01

    Teaching encourage can lead to student’s learning motivation and interesting. It improves the effect of classroom teach⁃ing. Methods of class teaching inspiration are: Target encourage, expectation encourage, emotional encourage, positive encourage, attribution encourage, competition encourage, caress encourage, democracy encourage, praise encourage, time encourage, check en⁃courage, questions encourage, examination encourage, score encourage, example encourage and understanding encourage.

  12. MATERIALS FOR LITERARY ENJOYMENT CLASS

    Directory of Open Access Journals (Sweden)

    Sarah Prasasti

    2000-01-01

    Full Text Available As the introductory class of literature at the Faculty of Letters, Literary Enjoyment serves as a campaign to motivate students to appreciate and enjoy works of literature. Materials, which generally hinder the students' ability to enjoy literary works, should be carefully considered. Ideally, language and content should be easily digested but a compromise can be made between language and content.

  13. Professional Elites in "Classes" Societies

    NARCIS (Netherlands)

    S.J. Magala (Slawomir)

    2003-01-01

    textabstractModern European identity has been forged in class struggles between the French revolution and fall of the Berlin Wall, which fell twice. Once, with the rest of the city in May 1945, when a national socialist alternative to a modernizing mix of parliamentary democracy and market economy c

  14. Class-Based Affirmative Action.

    Science.gov (United States)

    Roach, Ronald

    2003-01-01

    Discusses class-based, or economic, affirmative action, touted by the Bush administration as a race-neutral alternative to race-conscious affirmative action in college admissions. Explores whether such policies will result in fewer minority admissions and considers the "fairness" of the approach. (SLD)

  15. A class of topological actions

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, Michel [Service de Physique Theorique de Saclay, F-91191, Gif-sur-Yvette (France); Girardi, Georges [LAPTH, Chemin de Bellevue, BP 110, F-74941 Annecy-le-Vieux cedex (France); Stora, Ramond [LAPTH, Chemin de Bellevue, BP 110, F-74941 Annecy-le-Vieux cedex (France); Thuillier, Frank [LAPTH, Chemin de Bellevue, BP 110, F-74941 Annecy-le-Vieux cedex (France)

    2005-08-01

    We review definitions of generalized parallel transports in terms of Cheeger-Simons differential characters. Integration formulae are given in terms of Deligne-Beilinson cohomology classes. These representations of parallel transport can be extended to situations involving distributions as is appropriate in the context of quantized fields.

  16. A Class of Topological Actions

    CERN Document Server

    Bauer, M; Stora, Raymond Félix; Thuillier, F

    2005-01-01

    We review definitions of generalized parallel transports in terms of Cheeger-Simons differential characters. Integration formulae are given in terms of Deligne-Beilinson cohomology classes. These representations of parallel transport can be extended to situations involving distributions as is appropriate in the context of quantized fields.

  17. Sigma-class glutathione transferases.

    Science.gov (United States)

    Flanagan, Jack U; Smythe, Mark L

    2011-05-01

    Mammalian cytosolic glutathione transferases (GSTs) can be grouped into seven classes. Of these, the sigma class is also widely distributed in nature, with isoforms found in both vertebrates and invertebrates. It contains examples of proteins that have evolved specialized functions, such as the cephalopod lens S-crystallins, the mammalian hematopoietic prostaglandin D(2) synthase, and the helminth 28-kDa antigen. In mammals, the sigma-class GST has both anti- and proinflammatory functions, depending on the type of immune response, and an immunomodulatory function is also associated with the enzyme from helminth parasites. In the fly, it is associated with a specific detoxication activity toward lipid oxidation products. Mice genetically depleted of the sigma-class GST, or transgenically overexpressing it, have provided insight into the physiological roles of the GST. Inhibitors of the mammalian enzyme developed by structure-based methods are effective in controlling allergic response. This review covers the structure, function, and pharmacology of vertebrate and invertebrate GSTs.

  18. Active Learning in Large Classes

    DEFF Research Database (Denmark)

    Gørtz, Inge Li

    2011-01-01

    the lectures in the course. The main idea is to use inductive, case-based learning, with many small exercises/ discussions during the lectures. We describe a framework for the lectures, that most lectures in the class were based on. The framework contains the conceive, design, and implement stage from the CDIO...

  19. Achieving world class maintenance status

    Energy Technology Data Exchange (ETDEWEB)

    Tomlingson, P.D. [Paul D. Tomingson Associates (United States)

    2007-08-15

    The article written by a management consultant, discusses the art of successful planning and operation of maintenance in mines considering factors such as benchmaking, key performance indices (KPIs) and frequency of procedures which can help achieve 'world class maintenance'. 1 fig.

  20. COOPERATIVE LEARNING IN LARGE CLASSES

    Institute of Scientific and Technical Information of China (English)

    GuoXiangju

    2004-01-01

    Teaching college English in large classes is a new challenge to teachers. To meet this challenge, the strategy of cooperative learning is practicable. This paper introduces cooperative learning and describes the experiment results, which prove the advantages of cooperative learning over competitive learning or individualistic learning.

  1. Ethnicity, class, and civil war

    DEFF Research Database (Denmark)

    Hechter, Michael Norman; Siroky, David

    2016-01-01

    Why are some countries prone to ethno-nationalist conflict, whereas others are plagued by class conflict? This is a question that has seldom been raised and rarely been examined empirically. This paper presents a social-structural theory to account for the variable incidence of these two forms...

  2. ¿Quiénes dirigen las instituciones educativas en Cali? Perfil de los directivos docentes en colegios públicos y privados de estratos 1 a 4 Quem dirige as instituições educativas em Cali? Peril dos diretores docentes em colégios públicos e particulares de classes baixa e média Who Runs the schools in Cali? A Proile of Public and Private School Administrators in Lower Income Areas

    Directory of Open Access Journals (Sweden)

    Norbella Miranda

    2011-12-01

    Full Text Available El objetivo de este artículo es proveer una descripción del perfil de los administradores de la educación que laboran en instituciones públicas y privadas de educación básica y media de estratos 1 a 4 en la ciudad de Santiago de Cali, a través de los rasgos demográficos, socioeconómicos, académicos y profesionales. El artículo es producto de una investigación sobre las condiciones de implementación de la política educativa colombiana Programa Nacional de Bilingüismo. Para el estudio se empleó una encuesta que fue respondida por 70 administradores escolares de 46 instituciones educativas de la ciudad. Los resultados mostraron que el perfil típico del administrador escolar corresponde a mujeres entre los 50y 60 años que tuvieron contacto con el idioma inglés durante sus estudios de básica secundaria, tienen título de Especialización como máximo nivel de formación alcanzado y cuentan con experiencia profesional superior a 11 años. Se hallaron diferencias entre los sectores público y privado: en el primero los directivos tienen un nivel más alto de formación académica y mejores salarios. Los resultados sugieren que se necesita mayor apoyo a la formación de los directivos del sector privado y un mejor reconocimiento económico a la labor desempeñada por los directivos docentes en ambos sectores.O objetivo deste artigo é prover uma descrição do perfil dos administradores da educação que trabalham em instituições públicas e particulares de educação básica e média de classes baixa e média na cidade de Santiago de Cali, por meio dos traços demográficos, socioeconómicos, acadêmicos e profissionais. O artigo é produto de uma pesquisa sobre as condições de implementação da política educativa colombiana Programa Nacional de Bilinguismo. Para o estudo, empregou-se uma enquete que foi respondida por 70 administradores escolares de 46 instituições educativas da cidade. Os resultados mostraram que o perfil

  3. Class Action Suits against Public Schools.

    Science.gov (United States)

    Mesibov, Laurie

    1984-01-01

    If a suit is brought as a class action, either plaintiff or defendant may move to uphold or challenge class certification. If neither does so, the court decides whether the action may be maintained as a class suit. Prerequisites for class certification from Rule 23 (Federal Rules of Civil Procedure) are explained. (TE)

  4. A Discussion Strategy for an Online Class

    Science.gov (United States)

    Reese-Durham, Nancy Faith

    2014-01-01

    As a former teacher of face-to-face classes now assigned to teach only online classes, Nancy Reese Durham found herself challenged to change to accommodate online learners. She was determined to provide an environment in the online class where the high level of discussion she had provided in face-to-face classes could flourish as well. Here she…

  5. Properties of $\\gamma$-Ray Burst Classes

    CERN Document Server

    Hakkila, J; Roiger, R J; Mallozzi, R S; Pendleton, G N; Meegan, C A; Hakkila, Jon; Haglin, David J.; Roiger, Richard J.; Mallozzi, Robert S.; Pendleton, Geoffrey N.; Meegan, Charles A.

    2000-01-01

    The three gamma-ray burst (GRB) classes identified by statistical clustering analysis (Mukherjee et al. 1998) are examined using the pattern recognition algorithm C4.5 (Quinlan 1986). Although the statistical existence of Class 3 (intermediate duration, intermediate fluence, soft) is supported, the properties of this class do not need to arise from a distinct source population. Class 3 properties can easily be produced from Class 1 (long, high fluence, intermediate hardness) by a combination of measurement error, hardness/intensity correlation, and a newly-identified BATSE bias (the fluence duration bias). Class 2 (short, low fluence, hard) does not appear to be related to Class 1.

  6. Trabalho e classes sociais Work and social classes

    Directory of Open Access Journals (Sweden)

    Fernando Haddad

    1997-10-01

    Full Text Available Exposição, discussão e refutação das principais tentativas de atualizar a teoria marxista de classes e posterior reavaliação dessa teoria à luz da transformação da ciência em fator de produção e da possível perda de centralidade do trabalho no processo produtivo, tendo por base as interpretações lógicas da obra de Marx feitas por Ruy Fausto.Exposition, discussion and refutation of the main attempts of actualizing marxist class theory and a posterior reevaluation of this theory taking into account the transformation of Science into a factor of production and of the possible centrality-loss of work in the productive process, based on the logic interpretations of Marx's work made by Ruy Fausto.

  7. FDM Video Classe: Modes d'emploi pour la classe (FDM Video Class: Classroom Uses).

    Science.gov (United States)

    Beacco, Marcella Di Giura

    1996-01-01

    Content and design of the videotape series FDM Video Classe, produced by the journal "Le francais dans le monde," are described and classroom uses suggested. The materials are from authentic television programs, selected to illustrate aspects of French culture. It is suggested that the teacher also provide students with supporting materials that…

  8. Physical characteristics of bright Class I methanol masers

    Science.gov (United States)

    Leurini, S.; Menten, K. M.; Walmsley, C. M.

    2016-07-01

    44 GHz line is almost always stronger than the 36 GHz maser. By comparison between observed isotropic photon luminosities and our model predictions, we infer maser beam solid angles of roughly 10-3 steradian. Conclusions: We find that the Class I masers can reasonably be separated into three families: the (J + 1)-1-J0-E type series, the (J + 1)0-J1-A type, and the J2-J1-E lines at 25 GHz. The 25 GHz lines behave in a different fashion from the other masers as they are only inverted at high densities above 106 cm-3 in contrast to other Class I masers. Therefore, the detection of maser activity in all three families is a clear indication of high densities.

  9. Class Transitions in Black Holes

    CERN Document Server

    Chakrabarti, S K

    2005-01-01

    A black hole spectrum is known to change from the hard state to the soft state when the energy spectral index $\\alpha$ ($F_E \\propto E^{-\\alpha}$) in, say, 2-20 keV range changes from $\\alpha \\sim 0.5$ to $\\sim 1.5$. However, this `classical' definition which characterizes black holes like Cyg X-1, becomes less useful for many objects such as GRS 1915+105 in which the spectral slope is seen to vary from one to the other in a matter of seconds and depending on whether or not winds form, the spectral slope also changes. The light curves and the colour-colour diagrams may look completely different on different days depending on the frequency and mode of switching from one spectral state to the other. Though RXTE observations have yielded wealth of information on such `variability classes' in GRS 1915+105, very rarely one has been able to observe how the object goes from one class to the other. In the present review, we discuss possible origins of the class transition and present several examples of such transiti...

  10. Do class size effects differ across grades?

    DEFF Research Database (Denmark)

    Nandrup, Anne Brink

    This paper contributes to the class size literature by analyzing whether short-run class size effects are constant across grade levels in compulsory school. Results are based on administrative data on all pupils enroled in Danish public schools. Identification is based on a government-imposed class...... size cap that creates exogenous variation in class sizes. Significant (albeit modest) negative effects of class size increases are found for children on primary school levels. The effects on math abilities are statistically different across primary and secondary school. Larger classes do not affect...

  11. Measuring Class Cohesion Based on Dependence Analysis

    Institute of Scientific and Technical Information of China (English)

    Zhen-Qiang Chen; Bao-Wen Xu; Yu-Ming Zhou

    2004-01-01

    Classes are the basic modules in object-oriented (OO) software, which consist of attributes and methods. Thus, in OO environment, the cohesion is mainly about the tightness of the attributes and methods of classes. This paper discusses the relationships between attributes and attributes, attributes and methods, methods and methods of a class based on dependence analysis. Then the paper presents methods to compute these dependencies. Based on these, the paper proposes a method to measure the class cohesion, which satisfies the properties that a good measurement should have. The approach overcomes the limitations of previous class cohesion measures, which consider only one or two of the three relationships in a class.

  12. A FRAMEWORK TO MEASURE CLASS COHESION

    Institute of Scientific and Technical Information of China (English)

    Xu Baowen; Chen Zhenqiang; Zhou Yuming

    2003-01-01

    Classes are the basic modules in Object-Oriented (OO) software, which consist of attributes and methods. Thus, in OO environment, the cohesion is mainly about how tightly the attributes and methods of classes cohere with each other. This letter discusses the relationships between attributes and attributes, attributes and methods, methods and methods of a class,and the properties of these relationships. Based on these properties, the letter proposes a new framework to measure the cohesion of a class. The approach overcomes the limitations of previous class cohesion measures, which consider only one or two of the three relationships in a class.

  13. A Class of Integrable Metrics

    CERN Document Server

    Anabalon, Andres

    2016-01-01

    In four dimensions, the most general metric admitting two Killing vectors and a rank-two Killing tensor can be parameterized by ten arbitrary functions of a single variable. We show that picking a special vierbien, reducing the system to eight functions, implies the existence of two geodesic and share-free, null congruences, generated by two principal null directions of the Weyl tensor. Thus, if the spacetime is an Einstein manifold, the Goldberg-Sachs theorem implies it is Petrov type D, and by explicit construction, is in the Carter class. Hence, our analysis provide an straightforward connection between the most general integrable structure and the Carter family of spacetimes.

  14. Equivariant characteristic classes of complex algebraic varieties

    CERN Document Server

    Cappell, Sylvain E; Schuermann, Joerg; Shaneson, Julius L

    2010-01-01

    Homology Hirzebruch characteristic classes for singular varieties have been recently defined by Brasselet-Schuermann-Yokura as an attempt to unify previously known characteristic class theories for singular spaces (e.g., MacPherson-Chern classes, Baum-Fulton-MacPherson Todd classes, and Goresky-MacPherson L-classes, respectively). In this note we define equivariant analogues of these classes for quasi-projective varieties acted upon by a finite group of algebraic automorphisms, and show how these can be used to calculate the homology Hirzebruch classes of global orbifolds. We also compute the new classes in the context of monodromy problems, e.g., for varieties that fiber equivariantly (in the complex topology) over a connected algebraic manifold.

  15. Mandatory Class 1 Federal Areas Web Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web service contains the following layers: Mandatory Class 1 Federal Area polygons and Mandatory Class 1 Federal Area labels in the United States. The polygon...

  16. Class Based Contextual Logic for DOOD

    Institute of Scientific and Technical Information of China (English)

    JoseK.Raphel; SiuCheungHui; 等

    1996-01-01

    Cntextual logic provides a mechanism to reason about modules.In this paper,this theory of modules if modules is extended to a context theory of classes where class is in the true spirit of object-oriented databases.The logic,referred to as CLOG,is class-based.CLOG supports class,object identity,multiple role of object, monotonic and non-monotonic inheritance of data and method,method factoring,views,derived and query classes.Views and derived classes are queries in themselves.Objects are pure data terms representing the ground instances of facts in the class.Object identity is a first class term in the logic.Inheritance is handled through delegation.

  17. Investment Company Series and Class Information

    Data.gov (United States)

    Securities and Exchange Commission — The Series and Class Report provides basic identification information for all active registered investment company series and classes that have been issued IDs by...

  18. Hirzebruch-Milnor classes of complete intersections

    CERN Document Server

    Maxim, Laurentiu; Schuermann, Joerg

    2012-01-01

    We prove a new formula for the Hirzebruch-Milnor classes of global complete intersections with arbitrary singularities describing the difference between the Hirzebruch classes and the virtual ones. This generalizes a formula for the Chern-Milnor classes in the hypersurface case that was conjectured by S. Yokura and was proved by A. Parusinski and P. Pragacz. It also generalizes a formula of T. Suwa for the Chern-Milnor classes of complete intersections with isolated singularities.

  19. Application of TBT in Reading Class

    Science.gov (United States)

    Yu, Hong-qin

    2007-01-01

    "TBT" means "task-based teaching". In a TBT class, students play the central role. In the class where students are provided with plenty of chances to be engaged in activities, the teacher is more like a patient listener rather than a talkative speaker. This paper mainly explores how task-based teaching is used in English reading class.

  20. Class composition influences on pupils' cognitive development

    NARCIS (Netherlands)

    Peetsma, T.; van der Veen, I.; Koopman, P.; van Schooten, E.

    2006-01-01

    The proportion of low-achieving children in a class can affect the progress of individual pupils in that class. Having a large proportion of low achievers in a class could slow down growth in cognitive achievement but, might also boost such growth, due to the effects of specialist teaching geared to

  1. 49 CFR 512.16 - Class determinations.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Class determinations. 512.16 Section 512.16... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONFIDENTIAL BUSINESS INFORMATION Agency Determination § 512.16 Class determinations. (a) The Chief Counsel may issue class determinations of categories of...

  2. 40 CFR 2.207 - Class determinations.

    Science.gov (United States)

    2010-07-01

    ... Confidentiality of Business Information § 2.207 Class determinations. (a) The General Counsel may make and issue a class determination under this section if he finds that— (1) EPA possesses, or is obtaining, related... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Class determinations. 2.207 Section...

  3. Factors Related to In-Class Spiritual Experience: Relationship between Pre-Class Scripture Reading, In-Class Note-Taking, and Perceived In-Class Spiritual Experiences

    Science.gov (United States)

    Hilton, John, III; Sweat, Anthony R.; Plummer, Kenneth

    2015-01-01

    The purpose of this study is to examine the relationship between student in-class note-taking and pre-class reading with perceived in-class spiritual and religious outcomes. This study surveyed 620 students enrolled in six different sections of an introductory religion course at a private religious university. Full-time religious faculty members…

  4. The Social Psychology of Class and Classism

    Science.gov (United States)

    Lott, Bernice

    2012-01-01

    In the United States, one is born into a family that can be identified as working class, middle class, or affluent--divisions that denote status and power, as defined by access to resources. This article explores the relationships between social class membership and a wide array of personal and social daily life experiences. It concludes with a…

  5. Flipping Quantitative Classes: A Triple Win

    Science.gov (United States)

    Swart, William; Wuensch, Karl L.

    2016-01-01

    In the "flipped" class, students use online materials to learn what is traditionally learned by attending lectures, and class time is used for interactive group learning. A required quantitative business class was taught as a flipped classroom in an attempt to improve student satisfaction in the course and reduce the "transactional…

  6. Conceptualizing "Homework" in Flipped Mathematics Classes

    Science.gov (United States)

    de Araujo, Zandra; Otten, Samuel; Birisci, Salih

    2017-01-01

    Flipped instruction is becoming more common in the United States, particularly in mathematics classes. One of the defining characteristics of this increasingly popular instructional format is the homework teachers assign. In contrast to traditional mathematics classes in which homework consists of problem sets, homework in flipped classes often…

  7. Encouraging Undergraduate Class Participation: A Student Perspective

    Science.gov (United States)

    Wright, Nichole S.; Gragg, Marcia N.; Cramer, Kenneth M.

    2009-01-01

    Undergraduate classes typically involve a professor lecturing to 100 or more students. Too often, this results in minimal opportunities for student participation. Positive reinforcement was used to promote student participation (i.e., defined as relevant comments or questions) in a second-year psychology class (N = 97). Class participation was…

  8. The Wisdom of Class-Size Reduction

    Science.gov (United States)

    Graue, Elizabeth; Hatch, Kelly; Rao, Kalpana; Oen, Denise

    2007-01-01

    In this study, the authors explore the implementation of a statewide class-size reduction program in nine high-poverty schools. Through qualitative methods, they examined how schools used class-size reduction to change staffing patterns and instructional programs. Requiring changes in space allocation, class-size reduction was accomplished through…

  9. Diffusion of Responsibility in College Classes

    Institute of Scientific and Technical Information of China (English)

    李珍珍

    2015-01-01

    Diffusion of responsibility takes place in college classes nowadays.The author points out diffusion of responsibility in college classes,analyses psychological reasons of diffusion of responsibility,and gives strategies on avoiding the diffusion of responsibility.The paper aims at doing some contribution to improving teaching quality of college class.

  10. Making the Most of Your Class Website

    Science.gov (United States)

    Dunn, Lemoyne S.

    2011-01-01

    Students today are electronically connected, and they expect their learning to be connected as well. Many college students prefer online classes, even if they live on campus. Students who do take face-to-face classes often expect the class to have an online communication component (such as a discussion board). However, despite the fact that K-12…

  11. Application of Class Activities in English Teaching

    Institute of Scientific and Technical Information of China (English)

    刘琦

    2015-01-01

    Beginning with the analysis of present English teaching,the article puts forward some questions occurring in English classes.Then it talks about the necessity of implementing class activities.Finally it further elaborates how to carry out class activities through three specific examples.

  12. White Middle Class Identities and Urban Schooling

    Science.gov (United States)

    Devine, Dympna; Savage, Mike; Ingram, Nicola

    2012-01-01

    The authors review "White middle class identities and urban schooling," by D. Reay, G. Crozier and D. James. This book focuses on the perspectives of white middle-class parents who make "against"-the-grain school choices for their children in urban England. It provides key insights into the dynamics of class practising that are…

  13. The Character Strengths of Class Clowns

    Directory of Open Access Journals (Sweden)

    Willibald F. Ruch

    2014-09-01

    Full Text Available Class clowns traditionally were studied as a type concept and identified via sociometric procedures. In the present study a variable-centered approach was favored and class clown behaviors were studied in the context of character strengths, orientations to happiness and satisfaction with life. A sample of 672 Swiss children and adolescents filled in an 18 item self-report instrument depicting class clown behaviors. A hierarchical model of class clown behaviors was developed distinguishing a general factor and the four positively correlated dimensions of identified as a class clown, comic talent, disruptive rule-breaker, and subversive joker. Analysis of the general factor showed that class clowns were primarily male, and tended to be seen as class clowns by the teacher. Analyses of the 24 character strengths of the VIA-Youth (Park & Peterson, 2006 showed that class clowns were high in humor and leadership, and low in strengths like prudence, self-regulation, modesty, honesty, fairness, perseverance, and love of learning. An inspection of signature strengths revealed that 75% of class clowns had humor as a signature strength. Furthermore, generally class clown behaviors were shown by students indulging in a life of pleasure, but low life of engagement. The four dimensions yielded different character strengths profiles. While all dimensions of class clowns behaviors were low in temperance strengths, the factors identified as the class clown and comic talent were correlated with leadership strengths and the two negative factors (disruptive rule-breaker, subversive joker were low in other directed strengths. The disruptive rule breaking class clown was additionally low in intellectual strengths. While humor predicted life satisfaction, class clowning tended to go along with diminished satisfaction with life. It is concluded that different types of class clowns need to be kept apart and need different attention by teachers.

  14. The character strengths of class clowns.

    Science.gov (United States)

    Ruch, Willibald; Platt, Tracey; Hofmann, Jennifer

    2014-01-01

    Class clowns traditionally were studied as a type concept and identified via sociometric procedures. In the present study a variable-centered approach was favored and class clown behaviors were studied in the context of character strengths, orientations to happiness and satisfaction with life. A sample of 672 Swiss children and adolescents filled in an 18 item self-report instrument depicting class clown behaviors. A hierarchical model of class clown behaviors was developed distinguishing a general factor and the four positively correlated dimensions of "identified as a class clown," "comic talent," "disruptive rule-breaker," and "subversive joker." Analysis of the general factor showed that class clowns were primarily male, and tended to be seen as class clowns by the teacher. Analyses of the 24 character strengths of the VIA-Youth (Park and Peterson, 2006) showed that class clowns were high in humor and leadership, and low in strengths like prudence, self-regulation, modesty, honesty, fairness, perseverance, and love of learning. An inspection of signature strengths revealed that 75% of class clowns had humor as a signature strength. Furthermore, class clown behaviors were generally shown by students indulging in a life of pleasure, but low life of engagement. The four dimensions yielded different character strengths profiles. While all dimensions of class clowns behaviors were low in temperance strengths, the factors "identified as the class clown" and "comic talent" were correlated with leadership strengths and the two negative factors ("disruptive rule-breaker," "subversive joker") were low in other directed strengths. The disruptive rule breaking class clown was additionally low in intellectual strengths. While humor predicted life satisfaction, class clowning tended to go along with diminished satisfaction with life. It is concluded that different types of class clowns need to be kept apart and need different attention by teachers.

  15. Bayesian variable selection for latent class models.

    Science.gov (United States)

    Ghosh, Joyee; Herring, Amy H; Siega-Riz, Anna Maria

    2011-09-01

    In this article, we develop a latent class model with class probabilities that depend on subject-specific covariates. One of our major goals is to identify important predictors of latent classes. We consider methodology that allows estimation of latent classes while allowing for variable selection uncertainty. We propose a Bayesian variable selection approach and implement a stochastic search Gibbs sampler for posterior computation to obtain model-averaged estimates of quantities of interest such as marginal inclusion probabilities of predictors. Our methods are illustrated through simulation studies and application to data on weight gain during pregnancy, where it is of interest to identify important predictors of latent weight gain classes.

  16. A FRAMEWORK TO MEASURE CLASS COHESION

    Institute of Scientific and Technical Information of China (English)

    XuBaowen; ChenZhenqiang; 等

    2003-01-01

    Chasses are the basic modules in Object-Oriented(OO)softvare,which consist of attributed and methods.Thus,in OO environment,the cohesion is mainly about how tightly the attributed and methods of classes cohere with each other.This letter discusses the relationships between attributes and attributes,attributes and methods,methods and methods of a class,and the properties of these relationships.Based on these properties,the letter proposes a new framework to measure the cohesion of a class.The approach overcomes the limitations of previous class cohesion measures,which comsider only one or two of the three relationships in class.

  17. A Class-Specific Optimizing Compiler

    Directory of Open Access Journals (Sweden)

    Michael D. Sharp

    1993-01-01

    Full Text Available Class-specific optimizations are compiler optimizations specified by the class implementor to the compiler. They allow the compiler to take advantage of the semantics of the particular class so as to produce better code. Optimizations of interest include the strength reduction of class:: array address calculations, elimination of large temporaries, and the placement of asynchronous send/recv calls so as to achieve computation/communication overlap. We will outline our progress towards the implementation of a C++ compiler capable of incorporating class-specific optimizations.

  18. Context-sensitive intra-class clustering

    KAUST Repository

    Yu, Yingwei

    2014-02-01

    This paper describes a new semi-supervised learning algorithm for intra-class clustering (ICC). ICC partitions each class into sub-classes in order to minimize overlap across clusters from different classes. This is achieved by allowing partitioning of a certain class to be assisted by data points from other classes in a context-dependent fashion. The result is that overlap across sub-classes (both within- and across class) is greatly reduced. ICC is particularly useful when combined with algorithms that assume that each class has a unimodal Gaussian distribution (e.g., Linear Discriminant Analysis (LDA), quadratic classifiers), an assumption that is not always true in many real-world situations. ICC can help partition non-Gaussian, multimodal distributions to overcome such a problem. In this sense, ICC works as a preprocessor. Experiments with our ICC algorithm on synthetic data sets and real-world data sets indicated that it can significantly improve the performance of LDA and quadratic classifiers. We expect our approach to be applicable to a broader class of pattern recognition problems where class-conditional densities are significantly non-Gaussian or multi-modal. © 2013 Elsevier Ltd. All rights reserved.

  19. HLA class I expression in bladder carcinomas.

    Science.gov (United States)

    Cabrera, T; Pedrajas, G; Cozar, J M; Garrido, A; Vicente, J; Tallada, M; Garrido, F

    2003-10-01

    HLA class I molecules are frequently lost in a large variety of human carcinomas, possibly because of T-cell immune selection of major histocompatibility complex class I deficient tumor variants. We report that this phenomenon is also a frequent event in bladder carcinomas. Of a total of 72 bladder carcinomas, 72% of the tumors had at least one alteration in HLA class I expression. These altered HLA class I phenotypes were classified as total HLA class I loss (25%; phenotype I); HLA-A or/and HLA-B locus-specific loss (12%; phenotype III); and HLA class I allelic loss (35%; phenotype II or IV). Comparison of histopathological parameters with HLA class I expression showed a statistically significant relationship with the degree of differentiation and tumor recurrence.

  20. Higher social class predicts increased unethical behavior.

    Science.gov (United States)

    Piff, Paul K; Stancato, Daniel M; Côté, Stéphane; Mendoza-Denton, Rodolfo; Keltner, Dacher

    2012-03-13

    Seven studies using experimental and naturalistic methods reveal that upper-class individuals behave more unethically than lower-class individuals. In studies 1 and 2, upper-class individuals were more likely to break the law while driving, relative to lower-class individuals. In follow-up laboratory studies, upper-class individuals were more likely to exhibit unethical decision-making tendencies (study 3), take valued goods from others (study 4), lie in a negotiation (study 5), cheat to increase their chances of winning a prize (study 6), and endorse unethical behavior at work (study 7) than were lower-class individuals. Mediator and moderator data demonstrated that upper-class individuals' unethical tendencies are accounted for, in part, by their more favorable attitudes toward greed.

  1. 77 FR 56174 - Proposed Establishment of Class D and Class E Airspace; Camp Guernsey, WY

    Science.gov (United States)

    2012-09-12

    ... 14 CFR Part 71 Proposed Establishment of Class D and Class E Airspace; Camp Guernsey, WY AGENCY... action proposes to establish Class D airspace and Class E airspace at Camp Guernsey Airport, Camp... holidays. An informal docket may also be examined during normal business hours at the Northwest...

  2. The bovine class II major histocompatibility complex: Serological definition and further characterization of class II haplotypes.

    NARCIS (Netherlands)

    Nilsson, Ph.R.

    1994-01-01

    In this thesis an analysis of the major histocompatibility complex (MHC) class II in cattle is reported, with emphasis on the development of class II serology. First, the production of class II alloantisera, and the serological definition of bovine MHC class II polymorphism is described. Subsequentl

  3. 76 FR 28306 - Amendment of Class D and Class E Airspace; Idaho Falls, ID

    Science.gov (United States)

    2011-05-17

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D and Class E Airspace; Idaho Falls, ID... existing Class D and Class E airspace at Idaho Falls, ID, by changing the name of the airport to Idaho Falls Regional Airport, and adjusting the geographic coordinates of the airport. This action also...

  4. 75 FR 63706 - Amendment of Class D and Class E Airspace; Klamath Falls, OR

    Science.gov (United States)

    2010-10-18

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D and Class E Airspace; Klamath Falls... amend Class D and Class E airspace at Klamath Falls, OR. Decommissioning of the Merrill ] Non-Directional Radio Beacon (NDB) at Klamath Falls Airport has made this action necessary for the safety...

  5. We are all ordinary people: perceptions of class and class differences in personal relationships

    NARCIS (Netherlands)

    Van Eijk, G.

    2009-01-01

    This paper examines people’s perceptions of class and class differences—in general and with regard to personal relationships. Data from an original survey on personal networks (n=195) shows that most people think they are middle class, although many lower class respondents classify themselves as wor

  6. The theories on inequality: class theory

    Directory of Open Access Journals (Sweden)

    Ali Arslan

    2006-11-01

    Full Text Available This stduy aims to analyse  class theory and its major expansions. In addition, the problems and dilemmas of class theory are discussed. Social inequality, either socially or economically, is one of the most common features of capitalist societies. Some people or some social groups have more money, more prestige, more privilege and more influence on the decision making process.               Two main strategies have been used for analysing and explaining inequalities. The first and most popular strategy is “class theory” which stresses ownership and control to explain class differentiation. It concentrates on the inequalities based mainly on the ownership or non-ownership of economic resources. Class theory was fathered by Karl Marx and especially developed by Marxist writers. Class analysts focus on identification of classes as the major social forces of society. There are two main schools of thought in class theory with their variations within each school: a Marxist Class Theory, b Weberian Class Theory  If the Marxist class analysis and Weberian class analysis are examined it will be seen that, two approaches are incompatible and it is impossible to synthesise them. Nevertheless, Hindess sees Weber’s view as the correction of and supplement to Marx’s ideas rather than an alternative. When the ideas of Marx and Weber are compared, it will be clearly seen that both Marx and Weber explain classes in relation to the economy. Nevertheless, while Marx defines classes in terms of the relations of production, Weber defines them in relation to the market. 

  7. 47 CFR 73.6017 - Digital Class A TV station protection of Class A TV and digital Class A TV stations.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Digital Class A TV station protection of Class A TV and digital Class A TV stations. 73.6017 Section 73.6017 Telecommunication FEDERAL... Broadcast Stations § 73.6017 Digital Class A TV station protection of Class A TV and digital Class A...

  8. Mining discriminative class codes for multi-class classification based on minimizing generalization errors

    Science.gov (United States)

    Eiadon, Mongkon; Pipanmaekaporn, Luepol; Kamonsantiroj, Suwatchai

    2016-07-01

    Error Correcting Output Code (ECOC) has emerged as one of promising techniques for solving multi-class classification. In the ECOC framework, a multi-class problem is decomposed into several binary ones with a coding design scheme. Despite this, the suitable multi-class decomposition scheme is still ongoing research in machine learning. In this work, we propose a novel multi-class coding design method to mine the effective and compact class codes for multi-class classification. For a given n-class problem, this method decomposes the classes into subsets by embedding a structure of binary trees. We put forward a novel splitting criterion based on minimizing generalization errors across the classes. Then, a greedy search procedure is applied to explore the optimal tree structure for the problem domain. We run experiments on many multi-class UCI datasets. The experimental results show that our proposed method can achieve better classification performance than the common ECOC design methods.

  9. Factor mixture modeling of the Penn State Worry Questionnaire: Evidence for distinct classes of worry.

    Science.gov (United States)

    Korte, Kristina J; Allan, Nicholas P; Schmidt, Norman B

    2016-01-01

    Worry, the anticipation of future threat, is a common feature of anxiety and mood psychopathology. Considerable research has examined the latent structure of worry to determine whether this construct reflects a dimensional or taxonic structure. Recent taxometric investigations have provided support for a unidimensional structure of worry; however, the results of these studies are limited in that taxometric approaches are unable to assess for the presence of more than two classes of a given construct. Given the complex nature of worry, it is possible that worry may actually reflect a latent structure comprised of multiple classes that cannot be assessed through taxometric approaches. Thus, it is important to utilize newer statistical techniques, such as factor-mixture modeling (FMM), which allow for a more nuanced assessment of the latent structure of a given psychological construct. The aim of the current study was to examine the latent structure of worry using FMM. It was predicted that worry would reflect a three-class structure comprised of (1) a class of low, normative levels of worry, (2) a class of moderate, subclinical worry, and (3) a class of high, pervasive worry. The latent class structure of worry was assessed using FMM in a sample of 1337 participants recruited from the community through a research clinic. Results revealed a three-class structure of the PSWQ comprising low, moderate-high, and high classes of worry. We also provided convergent and discriminant validity of the worry classes by demonstrating that the high worry class was most associated with GAD and that the low worry class was the least associated with GAD. The clinical utility of the worry classes, including the creation of empirically based cut-scores, and the implications for future research are discussed.

  10. A new Class of Extremal Composites

    DEFF Research Database (Denmark)

    Sigmund, Ole

    2000-01-01

    The paper presents a new class of two-phase isotropic composites with extremal bulk modulus. The new class consists of micro geometrics for which exact solutions can be proven and their bulk moduli are shown to coincide with the Hashin-Shtrikman bounds. The results hold for two and three dimensions...... and for both well- and non-well-ordered isotropic constituent phases. The new class of composites constitutes an alternative to the three previously known extremal composite classes: finite rank laminates, composite sphere assemblages and Vigdergauz microstructures. An isotropic honeycomb-like hexagonal...... microstructure belonging to the new class of composites has maximum bulk modulus and lower shear modulus than any previously known composite. Inspiration for the new composite class comes from a numerical topology design procedure which solves the inverse homogenization problem of distributing two isotropic...

  11. Revisiting Parametric Types and Virtual Classes

    DEFF Research Database (Denmark)

    Madsen, Anders Bach; Ernst, Erik

    2010-01-01

    This paper presents a conceptually oriented updated view on the relationship between parametric types and virtual classes. The traditional view is that parametric types excel at structurally oriented composition and decomposition, and virtual classes excel at specifying mutually recursive families...... of classes whose relationships are preserved in derived families. Conversely, while class families can be specified using a large number of F-bounded type parameters, this approach is complex and fragile; and it is difficult to use traditional virtual classes to specify object composition in a structural...... manner, because virtual classes are closely tied to nominal typing. This paper adds new insight about the dichotomy between these two approaches; it illustrates how virtual constraints and type refinements, as recently introduced in gbeta and Scala, enable structural treatment of virtual types; finally...

  12. MFV-Class:a multi-faceted visualization tool of object classes

    Institute of Scientific and Technical Information of China (English)

    张志猛; 潘云鹤; 庄越挺

    2004-01-01

    Classes are key software components in an object-oriented software system. In many industrial OO software systems,there are some classes that have complicated structure and relationships. So in the processes of software maintenance,testing,software reengineering,software reuse and software restructure,it is a challenge for software engineers to understand these classes thoroughly. This paper proposes a class comprehension model based on constructivist learning theory,and implements a software visualization tool(MFV-Class)to help in the comprehension of a class. The tool provides multiple views of class to uncover manifold facets of class contents. It enables visualizing three object-oriented metrics of classes to help users focus on the understanding process. A case study was conducted to evaluate our approach and the toolkit.

  13. Characteristic Classes and Integrable Systems

    CERN Document Server

    Levin, A; Smirnov, A; Zotov, A

    2010-01-01

    The classical Calogero-Moser (CM) system related to a simple Lie group $G$ can be described as the Hitchin system coming from a topologically trivial Higgs $G$-bundle. We consider topologically non-trivial Higgs bundles and construct corresponding integrable systems. We call them the modified Calogero-Moser systems (MCM systems). Their phase space has the same dimension as the phase space of the standard CM systems with spin, but have less number of particles but greater number of the spin variables. Topology of the underlying holomorphic bundles are defined by their characteristic classes. Such bundles occur if $G$ has a non-trivial center, i.e. classical simply-connected groups, $E_6$ and $E_7$. Starting with these bundles we construct new integrable systems, their Lax operators, quadratic Hamiltonians, define the phase spaces and the Poisson structure using dynamical r-matrices. To describe the systems we construct a special basis in the Lie algebras that generalizes the basis of t'Hooft matrices for sl(N)...

  14. Class IIc or Circular Bacteriocins

    Science.gov (United States)

    Martin-Visscher, Leah A.; van Belkum, Marco J.; Vederas, John C.

    The circular bacteriocins produced by Gram-positive bacteria represent a diverse class of antimicrobial peptides. These bacteriocins display enhanced stability compared to linear bacteriocins, which arises from their characteristic circular backbone. Currently, eight unique circular bacteriocins have been identified, and analysis of their gene clusters indicates that they likely utilize complex mechanisms for maturation and secretion, as well as for immunity. These bacteriocins target the cytoplasmic membrane of sensitive cells, leading to pore formation that results in loss of ions, dissipation of membrane potential, and ultimately, cell death. Structural studies suggest that despite variation in their sequences, most of these bacteriocins likely adopt a common three-dimensional architecture, consisting of four or five tightly packed helices encompassing a hydrophobic core. There are many mysteries surrounding the biosynthesis of these peptides, particularly in regard to the mechanism by which they are cyclized. Elucidation of such a mechanism may provide exciting new approaches to the bioengineering of new, stable, and antimicrobially active circular peptides.

  15. New class of neutron detectors

    Energy Technology Data Exchange (ETDEWEB)

    Czirr, J.B.

    1997-09-01

    An optimized neutron scattering instrument design must include all significant components, including the detector. For example, useful beam intensity is limited by detector dead time; detector pixel size determines the optimum beam diameter, sample size, and sample to detector distance; and detector efficiency vs. wavelength determines the available energy range. As an example of the next generation of detectors that could affect overall instrumentation design, we will describe a new scintillator material that is potentially superior to currently available scintillators. We have grown and tested several small, single crystal scintillators based upon the general class of cerium-activated lithium lanthanide borates. The outstanding characteristic of these materials is the high scintillation efficiency-as much as five times that of Li-glass scintillators. This increase in light output permits the practical use of the exothermic B (n, alpha) reaction for low energy neutron detection. This reaction provides a four-fold increase in capture cross section relative to the Li (n, alpha) reaction, and the intriguing possibility of demanding a charged-particle/gamma ray coincidence to reduce background detection rates. These new materials will be useful in the thermal and epithermal energy ran at reactors and pulsed neutron sources.

  16. Research on Improving College English Classes

    Institute of Scientific and Technical Information of China (English)

    孙洁

    2009-01-01

    This essay is based on observation of totally four classes given by two teachers. Through careful observation, teal tape-recordings, detailed notes and serious comparison of their classes, the observer wants to find the different ap-proaches and methods they use, and how they give the classes while they are with different teaching experience, and fi-nally what the reactions of students are.

  17. Rough Class on a Completely Distributive Lattice

    Institute of Scientific and Technical Information of China (English)

    陈德刚; 张文修; 宋士吉

    2003-01-01

    This paper generalizes the Pawlak rough set method to a completely distributive lattice. Theconcept of a rough set has many applications in data mining. The approximation operators on a completelydistributive lattice are studied, the rough class on a completely distributive lattice is defined and theexpressional theorems of the rough class are proven. These expressional theorems are used to prove that thecollection of all rough classes is an atomic completely distributive lattice.

  18. Class, Mothering and the Values of Food

    DEFF Research Database (Denmark)

    Aamann, Iben Charlotte

    2015-01-01

    The data analysed in this empirical paper stems from ethnographic fieldwork among new school parents at three Danish primary schools. I draw on empirically grounded theories on the cultural and subjective dimensions of class, inspired by the “English School” of poststructuralist informed, feminist...... potential for the development of empirically grounded theories on class in Scandinavian society, where class hitherto has been ascribed as a thing from the past....

  19. ON THE SPH-DISTRIBUTION CLASS

    Institute of Scientific and Technical Information of China (English)

    Shi Dinghua; Guo Jinli; Liu Liming

    2005-01-01

    Following up Neuts'idea, the SPH-distribution class associated with bounded Q matrices for infinite Markov chains is defined. The main result in this paper is to characterize the SPH class through the derivatives of the distribution functions. Based on the characterization theorem, closure properties, the expansion, uniform approximation,and the matrix representations of the SPH class are also discussed by the derivatives of the distribution functions at origin.

  20. Entertainment with Learning Value in Astronomy Classes

    Science.gov (United States)

    Marscher, Alan P.

    2011-05-01

    As all teachers know, learning requires the attention of the students, which tends to wane as time goes on during a class. Entertainment is a means of restoring that attention. It is even more effective at reaching the goals of the class if the content of the entertainment reinforces the lesson. The presenter will demonstrate how he does this through songs that he composes and performs at selected times in some of his classes.

  1. The Continuing Story of Class IIa Bacteriocins

    OpenAIRE

    Drider, Djamel; Fimland, Gunnar; Héchard, Yann; McMullen, Lynn M.; Prévost, Hervé

    2006-01-01

    Many bacteria produce antimicrobial peptides, which are also referred to as peptide bacteriocins. The class IIa bacteriocins, often designated pediocin-like bacteriocins, constitute the most dominant group of antimicrobial peptides produced by lactic acid bacteria. The bacteriocins that belong to this class are structurally related and kill target cells by membrane permeabilization. Despite their structural similarity, class IIa bacteriocins display different target cell specificities. In the...

  2. Class of positive partial transposition states

    Science.gov (United States)

    Chruściński, Dariusz; Kossakowski, Andrzej

    2006-08-01

    We construct a class of quantum bipartite d⊗d states which are positive under partial transposition (PPT states). This class is invariant under the maximal commutative subgroup of U(d) and contains as special cases many well-known examples of PPT states. States from our class provide criteria for testing the indecomposability of positive maps. Such maps are crucial for constructing entanglement witnesses.

  3. The social psychology of class and classism.

    Science.gov (United States)

    Lott, Bernice

    2012-11-01

    In the United States, one is born into a family that can be identified as working class, middle class, or affluent-divisions that denote status and power, as defined by access to resources. This article explores the relationships between social class membership and a wide array of personal and social daily life experiences. It concludes with a discussion of classism, which contributes to diminished opportunities for low-income families.

  4. 7 CFR 1005.51 - Class I differential, adjustments to Class I prices, and Class I price.

    Science.gov (United States)

    2010-01-01

    ... (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE APPALACHIAN MARKETING AREA Order Regulating Handling Class Prices § 1005.51 Class I... VA BEDFORD CITY 51515 0.40 VA BRISTOL CITY 51520 0.40 VA BUENA VISTA CITY 51530 0.10 VA CLIFTON...

  5. Feature selection for multi-class problems by using pairwise-class and all-class techniques

    Science.gov (United States)

    You, Mingyu; Li, Guo-Zheng

    2011-05-01

    Feature selection has been a key technology in massive data processing, e.g. in microarray data analysis with few samples but high-dimensional genes. One common problem in multi-class microarray data analysis is the unbalanced recognition or prediction accuracies among classes, which usually leads to poor system performance. One of the main reasons is the unfair feature (gene) selection method. In this paper, a novel feature selection framework by using pairwise-class and all-class techniques (namely FrPA) is proposed to balance the performance among classes and improve the average accuracy. The feature (gene) rank list on all classes and the lists on each pair of classes are all taken into consideration during feature selection. The strategy of round-robin is embedded into the framework to select final features from the different rank lists. Experimental results on several microarray data sets show that FrPA helps to achieve higher classification accuracy and balance the performance among classes.

  6. Main: TGA1ANTPR1A [PLACE

    Lifescience Database Archive (English)

    Full Text Available TGA1ANTPR1A S000247 16-Feb-2001 (last modified) seki TGA1a binding site in tobacco ...(N.t.) PR1a gene; as-1-like sequence; Contains two TGACG elements reminiscent of activation sequence-1 (as-1...); See other as-1-like sequences; TGA1a is preferentially expressed in root tip meristems; TGA1a may contrib...ute to the expression of GST isoenzymes, especially in root tip meristems; TGA1a;... as-1; PR1a; xenobiotic stress; root; tip; meristem; tobacco (Nicotiana tabacum) CGTCATCGAGATGACG ...

  7. Investigation of Class 2b Trucks

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2002-04-03

    The popularity of trucks in the class 2 category--that is, those with a 6,000 to 10,000 pounds (lbs) gross vehicle weight rating (GVWR)--has increased since the late 1970s/early 1980s. The purpose of this research is to identify and examine vehicles in the upper portion of the class 2 weight range (designated as vehicle class 2b) and to assess their impact. Vehicles in class 2b (8,500-10,000 lbs GVWR) include pickup trucks, sport utility vehicles (SUVs), and large vans (i.e., not minivans). Oak Ridge National Laboratory researched each individual truck model to determine which models were class 2b trucks and arrived at four methodologies to derive sales volumes. Two methods--one for calendar year and one for model year sales--were recommended for producing believable and reliable results. The study indicates that 521,000 class 2b trucks were sold in calendar year 1999--6.4% of sales of all trucks under 10,000 lbs. Eighty-two percent of class 2b trucks sold in 1999 were pickups; one third of class 2b trucks sold in 1999 were diesel. There were 5.8 million class 2b trucks on the road in 2000, which amounts to 7.8% of all trucks under 10,000 lbs. Twenty-four percent of the class 2b truck population is diesel. Estimates show that class 2b trucks account for 8% of annual miles traveled by trucks under 10,000 lbs and 9% of fuel use. Data on class 2b trucks are scarce. As the Tier 2 standards, which apply to passenger vehicles in the 8,500-10,000 lb GVWR category, become effective, additional data on class 2b trucks may become available--not only emissions data, but data in all areas. At the moment, distinguishing class 2b trucks from class 2 trucks in general is a substantial task requiring data on an individual model level.

  8. Operationalizing Max Weber's probability concept of class situation: the concept of social class.

    Science.gov (United States)

    Smith, Ken

    2007-03-01

    In this essay I take seriously Max Weber's astonishingly neglected claim that class situation may be defined, not in categorial terms, but probabilistically. I then apply this idea to another equally neglected claim made by Weber that the boundaries of social classes may be determined by the degree of social mobility within such classes. Taking these two ideas together I develop the idea of a non-categorial boundary 'surface' between classes and of a social class 'corridor' made up of all those people who are still to be found within the boundaries of the social class into which they were born. I call social mobility within a social class 'intra-class social mobility' and social mobility between classes 'inter-class social mobility'. I also claim that this distinction resolves the dispute between those sociologists who claim that late industrial societies are still highly class bound and those who think that this is no longer the case. Both schools are right I think, but one is referring to a high degree of intra-class social mobility and the other to an equally high degree of inter-class mobility. Finally I claim that this essay provides sociology with only one example among many other possible applications of how probability theory might usefully be used to overcome boundary problems generally in sociology.

  9. Gamma-Ray Burst Class Properties

    Science.gov (United States)

    Hakkila, Jon; Haglin, David J.; Pendleton, Geoffrey N.; Mallozzi, Robert S.; Meegan, Charles A.; Roiger, Richard J.

    2000-01-01

    Guided by the supervised pattern recognition algorithm C4.5 developed by Quinlan in 1986, we examine the three gamma-ray burst classes identified by Mukherjee et al. in 1998. C4.5 provides strong statistical support for this classification. However, with C4.5 and our knowledge of the Burst and Transient Source Experiment (BATSE) instrument, we demonstrate that class 3 (intermediate fluence, intermediate duration, soft) does not have to be a distinct source population: statistical/systematic errors in measuring burst attributes combined with the well-known hardness/intensity correlation can cause low peak flux class 1 (high fluence, long, intermediate hardness) bursts to take on class 3 characteristics naturally. Based on our hypothesis that the third class is not a distinct one, we provide rules so that future events can be placed in either class 1 or class 2 (low fluence, short, hard). We find that the two classes are relatively distinct on the basis of Band's work in 1993 on spectral parameters alpha, beta, and E (sub peak) alone. Although this does not indicate a better basis for classification, it does suggest that different physical conditions exist for class 1 and class 2 bursts. In the process of studying burst class characteristics, we identify a new bias affecting burst fluence and duration measurements. Using a simple model of how burst duration can be underestimated, we show how this fluence duration bias can affect BATSE measurements and demonstrate the type of effect it can have on the BATSE fluence versus peak flux diagram.

  10. Plantaricin IIA-1A5 from Lactobacillus plantarum IIA-1A5 displays bactericidal activity against Staphylococcus aureus.

    Science.gov (United States)

    Arief, I Isnafia; Budiman, C; Jenie, B Sri Laksmi; Andreas, E; Yuneni, A

    2015-01-01

    Plantaricin IIA-1A5 is a bacteriocin produced by Lactobacillus plantarum IIA-1A5 isolated from Indonesian beef. This research aimed to identify the genes involved in plantaricin IIA-1A5 production and examine its mode of action against Staphylococcus aureus. It has been reported that a bacteriocin structural gene, plnW, is present in genome of L. plantarum IIA-1A5. Here, we reported the presence of additional genes responsible for plantaricin precursor (plnA and plnEF) and a gene encoding the quorum sensor of histidine kinase (plnB). It indicates that genes involved in production of plantaricin IIA-1A5 are organized in at least two bacteriocin operons (plnABCD, plnEFI) and a structural plnW gene. Purified plantaricin IIA-1A5 yielded a single band in SDS-PAGE with apparent size of 6.4 kDa. Amino acid composition of purified plantaricin IIA-1A5 was mainly composed of cationic glutamic acid and cysteine that allowed the formation of disulphide bonds, suggesting plantaricin IIA-1A5 belongs to the pediocin-subclass of class II bacteriocins. Plantaricin IIA-1A5 displayed remarkable antibacterial activity against S. aureus, which was initiated by the adsorption of plantaricin IIA-1A5 onto the cell membrane of S. aureus. The adsorption is hypothesised to be facilitated by non-ionic interactions as it is reduced by the presence of organic solvents or detergents. This adsorption promoted leakage of cellular metabolites through the cell membrane of S. aureus, as indicated by the release of genetic and proteinaceous material of S. aureus observed at 260 and 280 nm, respectively. The leakage also promoted the release of divalent (Ca(2+), Mg(2+)) and monovalent (K(+)) cations. The release of these intracellular components might be due to pores formed in the cell membrane of S. aureus by plantaricin IIA-1A5 as shown by scanning electron microscopy. Altogether, the mode of action of plantaricin IIA-1A5 against S. aureus seems to be bactericidal as indicated by lysis of the cell

  11. A conceptualisation of whole-class scaffolding

    NARCIS (Netherlands)

    Smit, J.; van Eerde, H.A.A.; Bakker, A.

    2013-01-01

    The concept of scaffolding refers to temporary and adaptive support, originally in dyadic adult– child interaction. It has become widely used, also in whole-class settings, but often in loose ways. The aim of this paper is to theoretically and empirically ground a conceptualisation of whole-class sc

  12. 7 CFR 29.6006 - Class.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Class. 29.6006 Section 29.6006 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Standards Definitions § 29.6006 Class. A major division of tobacco based on method of cure...

  13. The YouTube Makeup Class

    Science.gov (United States)

    Haase, David G.

    2009-01-01

    When a college instructor goes out of town and must miss a lecture, the standard options are to cancel the class meeting or to enlist a colleague to fill in. In the former case a teaching opportunity is lost; in the latter the substitute may not lead the class in the same way as the instructor. Some students routinely skip lectures by a guest…

  14. An Expert EFL Teacher's Class Management

    Science.gov (United States)

    Yazdanmehr, Elham; Akbari, Ramin

    2015-01-01

    The present research sought to investigate how expert EFL teachers manage their class and keep its discipline. To this aim, the existing prior ELT (English Language Teaching) research on exemplary teachers' practices were reviewed and the typical class management strategies used were extracted. Moreover, 20 ELT specialists including teacher…

  15. The cycle classes of divisorial Maroni loci

    OpenAIRE

    van der Geer, Gerard; Kouvidakis, Alexis

    2015-01-01

    We determine the cycle classes of effective divisors in the compactified Hurwitz spaces of curves of genus g with a linear system of degree d that extend the Maroni divisors on the open Hurwitz space. Our approach uses Chern classes associated to a global-to-local evaluation map of a vector bundle over a generic $P^1$-bundle over the Hurwitz space.

  16. Using Mobile Phone Technology in EFL Classes

    Science.gov (United States)

    Sad, Süleyman Nihat

    2008-01-01

    Teachers of English as a foreign language (EFL) who want to develop successful lessons face numerous challenges, including large class sizes and inadequate instructional materials and technological support. Another problem is unmotivated students who refuse to participate in class activities. According to Harmer (2007), uncooperative and…

  17. Class, Family, and Schizophrenia: A Reformulation

    Science.gov (United States)

    Kohn, Melvin L.

    1972-01-01

    The condition of life experienced by people of lower social-class position tend to impair their ability to deal resourcefully with the problematic and the stressful. Such impairment would result only for people who are both genetically vulnerable and exposed to considerable stress--these may affect the lowest social classes with special severity.…

  18. Gender, Class and Rurality: Australian Case Studies

    Science.gov (United States)

    Bryant, Lia; Pini, Barbara

    2009-01-01

    The interrelationship between gender and class in rural spaces has received little attention. While rural scholars have focused on the implications for class from processes of gentrification and agricultural and rural restructuring, these analyses have remained largely ungendered. Similarly, feminist rural studies have rarely explored subjectivity…

  19. Performance of TCP with multiple Priority Classes

    NARCIS (Netherlands)

    Vranken, R.; Mei, van der R.D.; Kooij, R.E.; Berg, van den J.L.

    2002-01-01

    We consider the dimensioning problem for Internet access links carrying TCP traffic with two priority classes. To this end, we study the behaviour of TCP at the flow level described by a multiple-server Processor Sharing (PS) queueing model with two customer classes, where the customers represent fl

  20. Flipping a Calculus Class: One Instructor's Experience

    Science.gov (United States)

    Palmer, Katrina

    2015-01-01

    This paper describes one instructor's experiences during a year of flipping four calculus classes. The first exploration attempts to understand student expectations of a math class and their preference towards a flipped classroom. The second examines success of students from a flipped classroom, and the last investigates relationships with student…

  1. The Power of In-Class Debates

    Science.gov (United States)

    Kennedy, Ruth R.

    2009-01-01

    The students in three sections of a class rated their knowledge and identified their view before and after each of five in-class debates. The degree of self-reported knowledge was significantly different after four of the five debates. Between 31% and 58% of participants changed their views after participating in or observing each debate. Some…

  2. Software Training Classes Now Open | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer                                            Data Management Services, Inc. (DMS), has announced the opening of its spring session of software training classes, available to all employees at NCI at Frederick. Classes begin on March 31 and run through June 30.

  3. Classes, Collection, and Principles of Psychological Organization.

    Science.gov (United States)

    Markman, Ellen M.

    This paper discusses research on how concepts differ in their internal organization and how these differences interact with and affect cognitive processing in children. Two types of natural concepts are focused on: classes (nouns with class-inclusion organization, such as "trees,""students,""soldiers" and collections (nouns with part-whole…

  4. So, Where Are We with Class Size?

    Science.gov (United States)

    Johnson, Donald P.

    2001-01-01

    Although class-size reductions cannot guarantee better student performance, the Tennessee and Wisconsin experiences, along with other studies, suggest that successful programs share key characteristics: concentration in the primary schooling years, classes with not more than 20 students, greater benefits for urban minority students, and alignment…

  5. Introduction to Latent Class Analysis with Applications

    Science.gov (United States)

    Porcu, Mariano; Giambona, Francesca

    2017-01-01

    Latent class analysis (LCA) is a statistical method used to group individuals (cases, units) into classes (categories) of an unobserved (latent) variable on the basis of the responses made on a set of nominal, ordinal, or continuous observed variables. In this article, we introduce LCA in order to demonstrate its usefulness to early adolescence…

  6. Various chapter styles for the memoir class

    DEFF Research Database (Denmark)

    Madsen, Lars

    2008-01-01

    Document showcasing various chapter title page designs either included in the LaTeX memoir class or is easily manually coded.......Document showcasing various chapter title page designs either included in the LaTeX memoir class or is easily manually coded....

  7. Researcher Perspectives on Class Size Reduction

    Science.gov (United States)

    Graue, Elizabeth; Rauscher, Erica

    2009-01-01

    This article applies to class size research Grant and Graue's (1999) position that reviews of research represent conversations in the academic community. By extending our understanding of the class size reduction conversation beyond published literature to the perspectives of researchers who have studied the topic, we create a review that includes…

  8. Two Classes of Models of Granular Computing

    Institute of Scientific and Technical Information of China (English)

    Daowu Pei

    2006-01-01

    This paper reviews a class of important models of granular computing which are induced by equivalence relations, or by general binary relations, or by neighborhood systems, and propose a class of models of granular computing which are induced by coverings of the given universe.

  9. Automatically extracting class diagrams from spreadsheets

    NARCIS (Netherlands)

    Hermans, F.; Pinzger, M.; Van Deursen, A.

    2010-01-01

    The use of spreadsheets to capture information is widespread in industry. Spreadsheets can thus be a wealthy source of domain information. We propose to automatically extract this information and transform it into class diagrams. The resulting class diagram can be used by software engineers to under

  10. Concerning Two Formulaic Classes in Computational Combinatorics

    Institute of Scientific and Technical Information of China (English)

    Leetsch C. HSU

    2012-01-01

    Here introduced and studied are two formulaic classes consisting of various combinatorial algebraic identities and series summation formulas.The basic ideas include utilizing properly the △-operator and Stirling numbers for some series transformations.A variety of classic formulas and remarkable identities are shown to be the members of the classes.

  11. Intercultural and Media Education on Art Classes

    Science.gov (United States)

    Borges, Maria José; Chaves, Anabela; Costa, Manuela; Pereira, Emília Sá

    2009-01-01

    Visual art, music and literature, are part of the culture. Thus Art shows the interactions between different cultures. The aim of the article is to present some activities to include intercultural issues in Art and Mother Language classes. Art classes also give the opportunity to do Media Education.

  12. A new class of PPT states

    CERN Document Server

    Chruscinski, D; Chruscinski, Dariusz; Kossakowski, Andrzej

    2006-01-01

    We construct a new class of PPT states for bipartite "d x d" systems. This class is invariant under the maximal commutative subgroup of U(d) and contains as special cases almost all known examples of PPT states. Theses states may be used to test the atomic property of positive maps which are crucial in studying quantum entanglement.

  13. Near-Ring Radicals and Class Pairs

    Institute of Scientific and Technical Information of China (English)

    L.Godloza; N.J.Groenewald; W.A.Olivier

    2005-01-01

    For near-ring ideal mappings p1 and p2, we investigate radical theoretical properties of and the relationship among the class pairs (p1: p2), (Sp2: Sp1) and (Rp2:Rp1). Conditions on p1 and p2 are given for a general class pair to form a radical class of various types. These types include the Plotkin and KA-radical varieties. A number of examples are shown to motivate the suitability of the theory of Hoehnke-radicals over KA-radicals when radical pairs of near-rings are studied. In particular, it is shown that (pc: P3) forms a KA-radical class, where Pc denotes the class of completely prime nearrings and P3 the class of 3-prime near-rings. This gives another near-ring generalization of the 2-primal ring concept. The theory of radical pairs are also used to show that in general the class of 3-semiprime near-rings is not the semisimple class of the 3-prime radical.

  14. Python Classes for Numerical Solution of PDE's

    CERN Document Server

    Mushtaq, Asif; Olaussen, Kåre

    2015-01-01

    We announce some Python classes for numerical solution of partial differential equations, or boundary value problems of ordinary differential equations. These classes are built on routines in \\texttt{numpy} and \\texttt{scipy.sparse.linalg} (or \\texttt{scipy.linalg} for smaller problems).

  15. The Making of the Black Middle Class.

    Science.gov (United States)

    Collins, Sharon M.

    1983-01-01

    Examines Black occupational mobility and factors that have influenced the growth of the Black middle class since the 1960s. Argues that the Black middle class occupies a fragile market position because Black mobility depends on fluctuating government policy rather than on free market factors. (Author/MJL)

  16. Genes, genetics, and Class III malocclusion.

    Science.gov (United States)

    Xue, F; Wong, R W K; Rabie, A B M

    2010-05-01

    To present current views that are pertinent to the investigation of the genetic etiology of Class III malocclusion. Class III malocclusion is thought to be a polygenic disorder that results from an interaction between susceptibility genes and environmental factors. However, research on family pedigrees has indicated that Class III malocclusion might also be a monogenic dominant phenotype. Recent studies have reported that genes that encode specific growth factors or other signaling molecules are involved in condylar growth under mechanical strain. These genes, which include Indian hedgehog homolog (IHH), parathyroid-hormone like hormone (PTHLH), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF), and variations in their levels of expression play an important role in the etiology of Class III malocclusion. In addition, genome-wide scans have revealed chromosomal loci that are associated with Class III malocclusion. It is likely that chromosomal loci 1p36, 12q23, and 12q13 harbor genes that confer susceptibility to Class III malocclusion. In a case-control association study, we identified erythrocyte membrane protein band 4.1 (EPB41) to be a new positional candidate gene that might be involved in susceptibility to mandibular prognathism. Most of the earlier studies on the genetic etiology of Class III malocclusion have focused on the patterns of inheritance of this phenotype. Recent investigations have focused on understanding the genetic variables that affect Class III malocclusion and might provide new approaches to uncovering the genetic etiology of this phenotype.

  17. Higher Education and Class: Production or Reproduction?

    Science.gov (United States)

    Sotiris, Panagiotis

    2013-01-01

    This article deals with questions relating to the role of education and especially Higher Education in the reproduction of class division in society. Social classes and how they are formed and reproduced has always been one of the greatest challenges for Marxism and social theory in general. The questions regarding the role of education, and…

  18. Special Classes for Gifted Students? Absolutely!

    Science.gov (United States)

    Burton-Szabo, Sally

    1996-01-01

    This article makes a case for special classes for gifted students and answers objections to special classes raised by the middle school movement and the cooperative learning movement. A sample "Celebration of Me" unit taught to gifted seventh graders which involved poetry, literature, personal development, art, music, and physical fitness is…

  19. HLA Class I and Class II Associations with ESRD in Saudi Arabian Population

    OpenAIRE

    Nuha Mahmoud Hamdi; Fadel Hassan Al-Hababi; Amr Ekhlas Eid

    2014-01-01

    BACKGROUND: Chronic renal failure (CRF) leads in the majority of instances to end stage renal disease (ESRD) requiring renal replacement therapy. Our interest was to evaluate the possible associations of HLA class I and class II antigens with ESRD independent of other factors, in Saudi Arabia population. METHODOLOGY: A retrospective study to determine the HLA class I and class II polymorphisms and their association with ESRD, was performed on 350 patients with ESRD, and 105 healthy unrelated ...

  20. [Latest advances of SLA class I genes].

    Science.gov (United States)

    Tao, Xuan; Li, Hua; Li, Xue-Wei; Yu, Hui; Zuo, Qi-Zhen

    2007-11-01

    The Swine leukocyte antigen (SLA) class I genes encode multi-glycoproteins on cell surface, which present endogenous antigenic peptides to T cells and thus initiate specific immune responses. In this article, latest advances on molecular structure, expression in tissues, regulation of expression, genotyping, polymorphism, and evolution of SLA class I genes were introduced, in which genotyping and polymorphism were emphasized. Molecular typing methods of SLA class I genes include serological method, DNA sequencing, PCR-SSP, PCR-SSOP and MS, of which PCR-SSP is frequently used in genotyping of SLA class I genes as a simple and rapid method. Future directions for the study and application of SLA class I genes on gene functions, peptide vaccine, xenotransplantation were also discussed.

  1. MATLAB tensor classes for fast algorithm prototyping.

    Energy Technology Data Exchange (ETDEWEB)

    Bader, Brett William; Kolda, Tamara Gibson (Sandia National Laboratories, Livermore, CA)

    2004-10-01

    Tensors (also known as mutidimensional arrays or N-way arrays) are used in a variety of applications ranging from chemometrics to psychometrics. We describe four MATLAB classes for tensor manipulations that can be used for fast algorithm prototyping. The tensor class extends the functionality of MATLAB's multidimensional arrays by supporting additional operations such as tensor multiplication. The tensor as matrix class supports the 'matricization' of a tensor, i.e., the conversion of a tensor to a matrix (and vice versa), a commonly used operation in many algorithms. Two additional classes represent tensors stored in decomposed formats: cp tensor and tucker tensor. We descibe all of these classes and then demonstrate their use by showing how to implement several tensor algorithms that have appeared in the literature.

  2. On Students' Self-Evaluation and Class Performance-An Empirical Study in College English Class

    Institute of Scientific and Technical Information of China (English)

    朱周贤

    2014-01-01

    This paper aims to demonstrate whether students' self-evaluations influence their class performance. A questionnaire is designed and data is collected from 30 sophomore students in English class. The data analysis shows that students who have posi-tive self-evaluation perform better and get higher class performance scores than students who have negative self-evaluation.

  3. The simple class II and class III corrector: three case reports.

    Science.gov (United States)

    Spary, David John; Little, Rachel Ann

    2015-03-01

    This article illustrates three case reports which describe a very simple appliance that is used to correct both class II and class III buccal segments. A class I molar relationship is achieved within 2-6 months. Hundreds of cases have been treated with these appliances over a number of years at Queen's Hospital, Burton upon Trent with great success.

  4. 78 FR 5754 - Proposed Amendment of Class D and Class E Airspace; Reading, PA

    Science.gov (United States)

    2013-01-28

    ... Class E Airspace; Reading, PA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to amend Class D and Class E Airspace at Reading... Approach Procedures (SIAPs) at Reading Regional/Carl A. Spaatz Field. This action would enhance the...

  5. 78 FR 21044 - Amendment of Class D and Class E Airspace; Reading, PA

    Science.gov (United States)

    2013-04-09

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D and Class E Airspace; Reading, PA... D and Class E Airspace at Reading, PA, as the SHAPP OM navigation aid has been decommissioned, requiring the modification of Standard Instrument Approach Procedures (SIAPs) at Reading Regional/Carl...

  6. Practical classes: a platform for deep learning? Overall context in the first-year veterinary curriculum.

    Science.gov (United States)

    Ryan, Marion T; Baird, Alan W; Mulholland, Clive W; Irwin, Jane A

    2009-01-01

    The aim of this study is to evaluate the many practical formats that support the first-year veterinary curriculum. These practical classes are diverse in content and style. They include laboratory-based formats, classes involving live animals and cadavers, classes conducted using computer-aided learning tools, study groups, and information technology training. This preliminary study examines ratings for these practical classes, but also relates these ratings to students' approaches to study with the aim of understanding how a deep learning approach manifests itself in the practical setting. The diverse behaviors and attitudes to practical classes are also evaluated in the light of the approaches to study. A questionnaire that evaluated (1) a total of 24 practical classes, (2) the 52-item Approaches to Study Inventory, and (3) 13 behaviors within and attitudes to practical classes was distributed to 69 first-year veterinary students in their final term. Practical classes that involved live animals and cadavers were rated most positively by this group of students. These ratings, however, did not correlate significantly with the deep or surface learning score. The majority of practical classes where the ratings were found to be associated with deep and surface learning were laboratory-based, although overall these practical classes tended to be rated lower than those involving animals. Ratings did not correlate significantly with the strategic approach. A number of behaviors and attitudes to practical classes were also found to be positively and significantly (p=0.0001) associated with the deep learning approach. This preliminary study indicates that this cohort of veterinary students has an overall positive perception of practical classes that permit contact with live animals or cadavers. Although the perception of laboratory-type practical classes was lower overall, the ratings for these practical classes appeared to be influenced by their deep and surface learning

  7. 25 CFR 522.10 - Individually owned class II and class III gaming operations other than those operating on...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Individually owned class II and class III gaming... GAMING COMMISSION, DEPARTMENT OF THE INTERIOR APPROVAL OF CLASS II AND CLASS III ORDINANCES AND RESOLUTIONS SUBMISSION OF GAMING ORDINANCE OR RESOLUTION § 522.10 Individually owned class II and class...

  8. Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single molecule kinetics

    DEFF Research Database (Denmark)

    Shi, J.; Palfey, B.A.; Dertouzos, J.

    2004-01-01

    of single enzyme molecules through the characteristic on-off fluorescence signal, which corresponds to flavin mononucleotide (FMN) interconverting between the oxidized and reduced states during turnover. Our single-molecule data provide evidence of a distinct static heterogeneity in the enzymatic activity...

  9. Social class and academic achievement in college: the interplay of rejection sensitivity and entity beliefs.

    Science.gov (United States)

    Rheinschmidt, Michelle L; Mendoza-Denton, Rodolfo

    2014-07-01

    Undergraduates, especially those from lower income backgrounds, may perceive their social class background as different or disadvantaged relative to that of peers and worry about negative social treatment. We hypothesized that concerns about discrimination based on one's social class (i.e., class-based rejection sensitivity or RS-class) would be damaging to undergraduates' achievement outcomes particularly among entity theorists, who perceive their personal characteristics as fixed. We reasoned that a perceived capacity for personal growth and change, characteristic of incremental theorists, would make the pursuit of a college degree and upward mobility seem more worthwhile and attainable. We found evidence across 3 studies that dispositionally held and experimentally primed entity (vs. incremental) beliefs predicted college academic performance as a function of RS-class. Studies 1a and 1b documented that high levels of both entity beliefs and RS-class predicted lower self-reported and official grades, respectively, among undergraduates from socioeconomically diverse backgrounds. In Study 2, high entity beliefs and RS-class at matriculation predicted decreased year-end official grades among lower class Latino students. Study 3 established the causal relationship of entity (vs. incremental) beliefs on academic test performance as a function of RS-class. We observed worse test performance with higher RS-class levels following an entity (vs. incremental) prime, an effect driven by lower income students. Findings from a 4th study suggest that entity theorists with RS-class concerns tend to believe less in upward mobility and, following academic setbacks, are prone to personal attributions of failure, as well as hopelessness. Implications for education and intervention are discussed.

  10. Minimum Data Set Q1a Report

    Data.gov (United States)

    U.S. Department of Health & Human Services — The MDS Q1a report summarizes, by state and county, percentages of residents that answered Yes to Q1a - Residents expresses or indicates preference to return to the...

  11. Early failure of Class II resin composite versus Class II amalgam restorations placed by dental students.

    Science.gov (United States)

    Overton, J D; Sullivan, Diane J

    2012-03-01

    Using the information from remake request slips in a dental school's predoctoral clinic, we examined the short-term survival of Class II resin composite restorations versus Class II dental amalgam restorations. In the student clinic, resin composite is used in approximately 58 percent of Class II restorations placed, and dental amalgam is used in the remaining 42 percent. In the period examined, Class II resin composite restorations were ten times more likely to be replaced at no cost to the patient than Class II dental amalgam restorations. A total of eighty-four resin composite restorations and six amalgam restorations were replaced due to an identified failure.

  12. Semi-longitudinal Study of the Mcnamara Cephalometric Triangle in Class II and Class III Subjects Grouped by Cervical Vertebrae Maturation Stage.

    Science.gov (United States)

    Arriola-Guillén, Luis E; Fitzcarrald, Fernando D; Flores-Mir, Carlos

    2015-12-01

    The aim was to compare the McNamara cephalometric triangle values in untreated normodivergent Class II and Class III malocclusion subjects of Latin American origin grouped by cervical vertebrae maturation stage to an untreated Class I malocclusion normodivergent control group. The study was conducted on a sample of 610 pretreatment lateral cephalograms (250 male, 360 female), examined and grouped according to their anteroposterior skeletal relationship (Class I, II or III), cervical vertebrae maturation stage (Pre Pubertal Peak P1 = CS1 and CS2, Pubertal Peak P2= CS3 and CS4, and Post Pubertal Peak P3 = CS5 and CS6) and sex. Co-A, Co-Gn and ENA-Me were measured in each lateral cephalogram. ANOVA and Tukey HSD post-hoc tests were performed to determine differences between the groups. The results showed that in males, the greatest maxillary and mandibular dimensional increases occurred during the P3 stage (CS5 to CS6), while in females, they occurred in the P2 stage (CS3 to CS4). The Co-A and Co-Gn showed significant differences between the malocclusion classes (pClass II subjects and the mandibular lengths in Class III subjects were already higher at the beginning of the period evaluated (P1). A worsening trend for the Class II and III malocclusions was identified during the period evaluated. Finally, changes in the McNamara cephalometric triangle values were markedly different in the three normodivergent skeletal malocclusion classes. In these Latin American subjects the pubertal growth spurt occurred at different times with respect to the Caucasian and Asian norms.

  13. Stiefel-Whitney classes of curve covers

    Science.gov (United States)

    Selander, Björn

    2016-10-01

    Let D be a Dedekind scheme with the characteristic of all residue fields not equal to 2. To every tame cover Cto D with only odd ramification we associate a second Stiefel-Whitney class in the second cohomology with mod 2 coefficients of a certain tame orbicurve [D] associated to D. This class is then related to the pull-back of the second Stiefel-Whitney class of the push-forward of the line bundle of half of the ramification divisor. This shows (indirectly) that our Stiefel-Whitney class is the pull-back of a sum of cohomology classes considered by Esnault, Kahn and Viehweg in `Coverings with odd ramification and Stiefel-Whitney classes'. Perhaps more importantly, in the case of a proper and smooth curve over an algebraically closed field, our Stiefel-Whitney class is shown to be the pull-back of an invariant considered by Serre in `Revêtements à ramification impaire et thêta-caractéristiques', and in this case our arguments give a new proof of the main result of that article.

  14. Early cephalometric characteristics in Class III malocclusion

    Directory of Open Access Journals (Sweden)

    Vanessa Costa Farias

    2012-04-01

    Full Text Available OBJECTIVE: Early identification of craniofacial morphological characteristics allows orthopedic segmented interventions to attenuate dentoskeletal discrepancies, which may be partially disguised by natural dental compensation. To investigate the morphological characteristics of Brazilian children with Class III malocclusion, in stages I and II of cervical vertebrae maturation and compare them with the characteristics of Class I control patients. METHODS: Pre-orthodontic treatment records of 20 patients with Class III malocclusion and 20 control Class I patients, matched by the same skeletal maturity index and sex, were selected. The craniofacial structures and their relationships were divided into different categories for analysis. Angular and linear measures were adopted from the analyses previously described by Downs, Jarabak, Jacobson and McNamara. The differences found between the groups of Class III patients and Class I control group, both subdivided according to the stage of cervical vertebrae maturation (I or II, were assessed by analysis of variance (ANOVA, complemented by Bonferroni's multiple mean comparisons test. RESULTS: The analysis of variance showed statistically significant differences in the different studied groups, between the mean values found for some angular (SNA, SNB, ANB and linear variables (Co - Gn, N - Perp Pog, Go - Me, Wits, S - Go, Ar - Go. CONCLUSION: Assessed children displaying Class III malocclusion show normal anterior base of skull and maxilla, and anterior positioning of the mandible partially related to increased posterior facial height with consequent mandibular counterclockwise rotation.

  15. A multi-class large margin classifier

    Institute of Scientific and Technical Information of China (English)

    Liang TANG; Qi XUAN; Rong XIONG; Tie-jun WU; Jian CHU

    2009-01-01

    Currently there are two approaches for a multi-class support vector classifier (SVC). One is to construct and combine several binary classifiers while the other is to directly consider all classes of data in one optimization formulation. For a K-class problem (K>2), the first approach has to construct at least K classifiers, and the second approach has to solve a much larger op-timization problem proportional to K by the algorithms developed so far. In this paper, following the second approach, we present a novel multi-class large margin classifier (MLMC). This new machine can solve K-class problems in one optimization formula-tion without increasing the size of the quadratic programming (QP) problem proportional to K. This property allows us to construct just one classifier with as few variables in the QP problem as possible to classify multi-class data, and we can gain the advantage of speed from it especially when K is large. Our experiments indicate that MLMC almost works as well as (sometimes better than) many other multi-class SVCs for some benchmark data classification problems, and obtains a reasonable performance in face recognition application on the AR face database.

  16. On Certain Classes of Multivalent Analytic Functions

    Directory of Open Access Journals (Sweden)

    Rabha W. Ibrahim

    2010-01-01

    Full Text Available Problem statement: By means of the Hadamard product (or convolution, new class of function of power order was formed. This class was motivated by many authors namely MacGregor, Umezawa, Darus and Ibrahim and many others. The class indeed extended in the form of integral operator due to the work of Bernardi, Libera and Livingston. Approach: A new class of multivalent analytic functions in the open unit disk U was introduced. An application of this class was posed by using the fractional integral operator. The integral operator of multivalent functions was proposed and defined. The previous well known integral operator was mentioned. Results: Having the integral operator, a class was defined and coefficient bounds established by using standard method. These results reduced to well-known results studied by various authors. The operator was then applied for fractional calculus and obtained the coefficient bounds. Conclusion: Therefore, new operators could be obtained with some earlier results and standard methods. New classes were formed and new results of special cases were obtained.

  17. Timely management of developing class III malocclusion

    Directory of Open Access Journals (Sweden)

    M R Yelampalli

    2012-01-01

    Full Text Available Timing of orthodontic treatment, especially for children with developing class III malocclusions, has always been somewhat controversial, and definitive treatment tends to be delayed for severe class III cases. Developing class III patients with moderate to severe anterior crossbite and deep bite may need early intervention in some selected cases. Class III malocclusion may develop in children as a result of an inherent growth abnormality, i.e. true class III malocclusion, or as a result of premature occlusal contacts causing forward functional shift of the mandible, which is known as pseudo class III malocclusion. These cases, if not treated at the initial stage of development, interfere with normal growth of the jaw bases and may result in severe facial deformities. The treatment should be carried out as early as possible for permitting normal growth of the skeletal bases. This paper deals with the selection of an appropriate appliance from the various current options available for early intervention in developing class III malocclusion through two case reports.

  18. Timely management of developing class III malocclusion.

    Science.gov (United States)

    Yelampalli, M R; Rachala, M R

    2012-01-01

    Timing of orthodontic treatment, especially for children with developing class III malocclusions, has always been somewhat controversial, and definitive treatment tends to be delayed for severe class III cases. Developing class III patients with moderate to severe anterior crossbite and deep bite may need early intervention in some selected cases. Class III malocclusion may develop in children as a result of an inherent growth abnormality, i.e. true class III malocclusion, or as a result of premature occlusal contacts causing forward functional shift of the mandible, which is known as pseudo class III malocclusion. These cases, if not treated at the initial stage of development, interfere with normal growth of the jaw bases and may result in severe facial deformities. The treatment should be carried out as early as possible for permitting normal growth of the skeletal bases. This paper deals with the selection of an appropriate appliance from the various current options available for early intervention in developing class III malocclusion through two case reports.

  19. Automatic Identification Systems the Effects of Class B on the Use of Class A Systems

    Science.gov (United States)

    Norris, Andy

    2006-05-01

    The standards for CSTDMA Class B AIS will shortly be published by the International Electrotechnical Commission and equipment will become available during 2006. The perceived benefits that Class B brings to leisure craft users and its relatively low cost will make it attractive in the market place. A rapid take-up of Class B use can therefore be expected. This paper considers the impact that increased use of Class B will have on users of Class A AIS that are compulsorily fitted to larger vessels to meet the requirements of the International Maritime Organization Safety of Life at Sea convention. The CSTDMA Class B system has been designed to prevent overloading of the AIS VHF data link. This is briefly reviewed but there are a number of other aspects that need to be considered. These include: the increased garbling of Class B messages compared to those of Class A; the problems accruing from the low update rate of Class B information; the increase in display information that will need to be managed; and the possible increase in inappropriate manoeuvres of leisure craft caused by misplaced reliance on AIS. As a result of the investigation the paper highlights the fact that Class B users must not assume that their own presence, in the form of Class B transmissions, will be particularly visible on the bridge of many SOLAS vessels. This will continue to be the case for many years into the future, until such vessels are mandated to carry radar with AIS target overlay capability.

  20. Two classes of gamma-ray bursts

    CERN Document Server

    Katz, J I

    1995-01-01

    Data from the 3B Catalogue suggest that short and long GRB are the results of different classes of events, rather than different parameter values within a single class: Short bursts have harder spectra in the BATSE bands, but chiefly long bursts are detected at photon energies over 1 MeV, implying that their hard photons are radiated by a process not found in short bursts. The values of \\langle V/V_{max} \\rangle for short and long bursts differ by 4.3 \\sigma, implying different spatial distributions. Only the soft gamma-ray radiation mechanisms are the same in both classes.

  1. Class 3 Tracking and Monitoring System Report

    Energy Technology Data Exchange (ETDEWEB)

    Safely, Eugene; Salamy, S. Phillip

    1999-11-29

    The objective of Class 3 tracking system are to assist DOE in tracking and performance and progress of these projects and to capture the technical and financial information collected during the projects' monitoring phase. The captured information was used by DOE project managers and BDM-Oklahoma staff for project monitoring and evaluation, and technology transfer activities. The proposed tracking system used the Class Evaluation Executive Report (CLEVER), a relation database for storing and disseminating class project data; GeoGraphix, a geological and technical analysis and mapping software system; the Tertiary Oil Recovery Information System (TORIS) database; and MS-Project, a project management software system.

  2. Study on Social Class and Language

    Institute of Scientific and Technical Information of China (English)

    徐琪

    2016-01-01

    Language is the most important tool for human communication.With the development in society,history and culture,variations in language come into being while the choice of linguistic items by speakers to communicate the same message may vary ,resulting from their different social sit⁃uations or class.Then the study on the interrelation between social class and language is needed.By studying the cases of Labov and Bernstein as well as characters’lines in some modern series,this paper tries to analyze the internal relations between language and social class.

  3. Three Ways to Improve Listening Classes

    Institute of Scientific and Technical Information of China (English)

    邓林竹

    2014-01-01

    Recent years have witnessed numerous studies on how to improve learners’listening comprehension and how to ef-fectively teach listening classes. Despite these efforts, some problems still exist in listening teaching methods in China. In the first part of the essay, three issues in listening classes will be identified. Based on these issues, the second part present three correspond-ing methods of incorporating communicative-based activities, videos and checklists into teaching to improve listening classes. Each method will be justified by relevant theories and literature. A conclusion will be made in the end.

  4. DEPENDENCE ANALYSIS FOR UML CLASS DIAGRAMS

    Institute of Scientific and Technical Information of China (English)

    Wu Fangjun; Yi Tong

    2004-01-01

    Though Unified Modeling Language (UML) has been widely used in software development, the major problems confronted lie in comprehension and testing. Dependence analysis is an important approach to analyze, understand, test and maintain programs. A new kind of dependence analysis method for UML class diagrams is developed. A set of dependence relations is definedcorresponding to the relations among classes. Thus, the dependence graph of UML class diagram can be constructed from these dependence relations. Based on this model, both slicing and measurement coupling are further given as its two applications.

  5. The Cosmology Large Angular Scale Surveyor (CLASS)

    Science.gov (United States)

    Eimer, Joseph; Ali, A.; Amiri, M.; Appel, J. W.; Araujo, D.; Bennett, C. L.; Boone, F.; Chan, M.; Cho, H.; Chuss, D. T.; Colazo, F.; Crowe, E.; Denis, K.; Dünner, R.; Essinger-Hileman, T.; Gothe, D.; Halpern, M.; Harrington, K.; Hilton, G.; Hinshaw, G. F.; Huang, C.; Irwin, K.; Jones, G.; Karakla, J.; Kogut, A. J.; Larson, D.; Limon, M.; Lowry, L.; Marriage, T.; Mehrle, N.; Miller, A. D.; Miller, N.; Moseley, S. H.; Novak, G.; Reintsema, C.; Rostem, K.; Stevenson, T.; Towner, D.; U-Yen, K.; Wagner, E.; Watts, D.; Wollack, E.; Xu, Z.; Zeng, L.

    2014-01-01

    The Cosmology Large Angular Scale Surveyor (CLASS) is an array of telescopes designed to search for the signature of inflation in the polarization of the Cosmic Microwave Background (CMB). By combining the strategy of targeting large scales (>2 deg) with novel front-end polarization modulation and novel detectors at multiple frequencies, CLASS will pioneer a new frontier in ground-based CMB polarization surveys. In this talk, I give an overview of the CLASS instrument, survey, and outlook on setting important new limits on the energy scale of inflation.

  6. Class IIa Bacteriocins: Current Knowledge and Perspectives

    Science.gov (United States)

    Belguesmia, Yanath; Naghmouchi, Karim; Chihib, Nour-Eddine; Drider, Djamel

    Lactic acid bacteria (LAB) are known to produce antibacterial peptides and small proteins called bacteriocins, which enable them to compete against other bacteria in the environment. Bacteriocins fall structurally and chemically into three different classes, I, II, and III. Bacteriocins are ribosomally synthesized peptides with antagonism against closely related bacteria. This late observation has evolved because bacteriocins active against Gram-negative bacteria have recently been reported. Members of class IIa bacteriocins, referred to as pediocin-like bacteriocins, are among the most studied bacteriocins. This chapter is aimed at providing an updated review on the biology of class IIa bacteriocins.

  7. Malocclusion class III treatment in teething decidua.

    OpenAIRE

    Chávez Sevillano, Manuel Gustavo; Departamento Académico de Estomatología Pediátrica, Facultad de Odontología de la Universidad Nacional Mayor de San Marcos, Lima, Perú.

    2014-01-01

    According as age increases, growth decreases and Class III skeletal patterns become more stable. The objective of Class III malocclusion’s treatment in primary dentition is to get a favorable environment to achieve a better dentofacial development. This article’s objective is to give a theorical summary about treatment of Class III malocclusions in primary dentition, and to present a case report. A medida que aumenta la edad, la cuantía de crecimiento disminuye y las clases III esquelética...

  8. The State of the Australian Middle Class

    Directory of Open Access Journals (Sweden)

    Clive Hamilton

    2008-09-01

    Full Text Available There is a widespread view that the middle class in Australia is doing it tough, that they arefinding it increasingly difficult to maintain a decent standard of living and are suffering frommortgage stress. Indeed, some media reports have announced the end of the middle classdream.This paper tests a number of these popular views against the statistical data. It asks whetherthe typical Australian family can be said to be struggling? Are mortgages creating severeproblems for middle-class families? Is the middle class shrinking? Are families copingfinancially only because wives are going out to work?

  9. Class and ideological orientations revisited: an exploration of class-based mechanisms.

    Science.gov (United States)

    Bengtsson, Mattias; Berglund, Tomas; Oskarson, Maria

    2013-12-01

    Studies of the relationship between class position and political outlooks still only have a limited understanding of the class-related mechanisms that matter for ideological orientations. This article presents a comprehensive analysis of the mechanisms that link class position and left/right and authoritarian/libertarian orientations. Besides main factors such as income, career prospects, job security, education, class origin and class identification, the significance of work-related factors such as work autonomy, working in a team, a physically demanding job and a mentally demanding job is studied. The findings are based on a survey specifically designed for this purpose and collected in Sweden in 2008/2009. A great deal of the association between class position and left/right orientations is explained by socio-economic conditions; different classes sympathize with policies that will benefit them economically. Another important factor is class identification. Work-related factors also have relevance, but the effect of class position on left/right orientations works mainly through the remuneration system. Class position is also related to authoritarian/libertarian orientations. However, this relationship is less explained by socio-economic position per se, but is rather an effect of the educational system and its allocation of the workforce into different class positions. It also turns out that work-related factors do not explain the class effects; however, a physically demanding job shows a unique effect. Overall, our findings suggest that besides factors such as class position, income, education and class identification, we need to consider work-related aspects to derive a more complete understanding of the distribution of ideological orientations in Western societies.

  10. Combination Classes and "Hora de comunicacion."

    Science.gov (United States)

    Eldredge, Dee L.

    1989-01-01

    Ways to combine small classes of higher education students studying Spanish at various levels are described, including judicious use of language laboratories, staggering of the different level groups, and rotation of activities geared toward students' individual proficiency levels. (CB)

  11. Gems: Nutrition Education in Childbirth Classes.

    Science.gov (United States)

    Easches, Janet G.; And Others

    1983-01-01

    Describes a nutrition education packet for natural childbirth (Lamaze) classes. The packet consists of four 15- to 20-minute lessons, each containing goal, objectives, questions (with answers), activities, and pamphlets. List of goals and sample activities are included. (JN)

  12. ON A CLASS OF RIEMANN SURFACES

    Institute of Scientific and Technical Information of China (English)

    Arturo Fernández; Javier Pérez

    2006-01-01

    It is considered the class of Riemann surfaces with dimT1 = 0, where T1 is a subclass of exact harmonic forms which is one of the factors in the orthogonal decomposition of the space ΩH of harmonic forms of the surface, namelyΩH = *Ω0H +T1 + *T0H + T0H + T2.The surfaces in the class OHD and the class of planar surfaces satisfy dimT1 = 0. A.Pfluger posed the question whether there might exist other surfaces outside those two classes. Here it is shown that in the case of finite genus g, we should look for a surface S with dimT1 = 0 among the surfaces of the form Sg\\K , where Sg is a closed surface of genus g and K a compact set of positive harmonic measure with perfect components and very irregular boundary.

  13. Hydrography - Class A Wild Trout Streams - points

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Class A streams are streams that support a population of wild (natural reproduction) trout of sufficient size and abundance to support a long-term and rewarding...

  14. Hydrography - Class A Wild Trout Streams

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Class A streams are streams that support a population of wild (natural reproduction) trout of sufficient size and abundance to support a long-term and rewarding...

  15. Diagrammatic Reasoning with Classes and Relationships

    DEFF Research Database (Denmark)

    Nilsson, Jørgen Fischer

    2013-01-01

    We present and discuss a diagrammatic visualization and reasoning language coming about by augmenting Euler diagrams with higraphs. The diagrams serve (hierarchical as well as trans-hierarchical) classification and specification of various logical relationships between classes. The diagrams rely...

  16. A new class of variational equation problems

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Applying an analysis method to a group of multivariable equations, a new class of variational equations are proved. This method is more concise and more direct than the others. This result can be applied to some stochastic control models.

  17. Green jobs and a strong middle class.

    Science.gov (United States)

    Podesta, John D

    2009-01-01

    Green jobs are critical to building a strong middle class, and millions of green jobs can be created through energy efficiency. The models already exist for this work, but we need sustained investment to bring them to scale.

  18. Teaching a Large Physics Class at Cornell.

    Science.gov (United States)

    Orear, Jay

    1979-01-01

    A professor discusses the advantages and disadvantages of teaching a physics class in a large research-oriented university. Various innovative teaching techniques and the ways in which they benefit the students, are presented. (SA)

  19. Effective Discovery of Exception Class Association Rules

    Institute of Scientific and Technical Information of China (English)

    周傲英; 魏藜; 俞舫

    2002-01-01

    In this paper, a new effective method is proposed to find class association rules (CAR), to get useful class association rules (UCAR) by removing the spurious class association rules (SCAR), and to generate exception class association rules (ECAR) for each UCAR. CAR mining, which integrates the techniques of classification and association, is of great interest recently. However, it has two drawbacks: one is that a large part of CARs are spurious and maybe misleading to users; the other is that some important ECARs are difficult to find using traditional data mining techniques. The method introduced in this paper aims to get over these flaws. According to our approach, a user can retrieve correct information from UCARs and know the influence from different conditions by checking corresponding ECARs. Experimental results demonstrate the effectiveness of our proposed approach.

  20. Class, Social Suffering, and Health Consumerism.

    Science.gov (United States)

    Merrild, Camilla Hoffmann; Risør, Mette Bech; Vedsted, Peter; Andersen, Rikke Sand

    2016-01-01

    In recent years an extensive social gradient in cancer outcome has attracted much attention, with late diagnosis proposed as one important reason for this. Whereas earlier research has investigated health care seeking among cancer patients, these social differences may be better understood by looking at health care seeking practices among people who are not diagnosed with cancer. Drawing on long-term ethnographic fieldwork among two different social classes in Denmark, our aim in this article is to explore the relevance of class to health care seeking practices and illness concerns. In the higher middle class, we predominantly encountered health care seeking resembling notions of health consumerism, practices sanctioned and encouraged by the health care system. However, among people in the lower working class, health care seeking was often shaped by the inseparability of physical, political, and social dimensions of discomfort, making these practices difficult for the health care system to accommodate.

  1. Hierarchies of television tastes and class distinctions

    Directory of Open Access Journals (Sweden)

    Dejan Jontes

    2012-12-01

    Full Text Available Drawing on data from the empirical research project Media consumption, social class and cultural stratification carried out with the help of a questionnaire administered to 820 residents of Ljubljana and Maribor, the paper examines the relationship between social class, education and television tastes. Contrary to some of the recent literature which emphasises a weak or non-existent connection between class positions and patterns of television consumption, the author uses the Slovenian sample to show that class and education differentiate television preferences significantly although only in some segments of the television repertoire. In the conclusion of the paper, the importance of studying television preferences in connection with other fields of cultural consumption is stressed.

  2. Acquired Class D β-Lactamases

    Directory of Open Access Journals (Sweden)

    Nuno T. Antunes

    2014-08-01

    Full Text Available The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae. The phenotypic and structural characteristics of these enzymes correlate to activities that are classified either as a narrow spectrum, an extended spectrum, or a carbapenemase spectrum. We focus on Class D β-lactamases that are carried on plasmids and, thus, present particular clinical concern. Following a historical perspective, the susceptibility and kinetics patterns of the important plasmid-encoded Class D β-lactamases and the mechanisms for mobilization of the chromosomal Class D β-lactamases are discussed.

  3. On nilpotent groups and conjugacy classes

    OpenAIRE

    Adan-Bante, Edith

    2005-01-01

    Let $G$ be a nilpotent group and $a\\in G$. Let $a^G=\\{g^{-1}ag\\mid g\\in G\\}$ be the conjugacy class of $a$ in $G$. Assume that $a^G$ and $b^G$ are conjugacy classes of $G$ with the property that $|a^G|=|b^G|=p$, where $p$ is an odd prime number. Set $a^G b^G=\\{xy\\mid x\\in a^G, y\\in b^G\\}$. Then either $a^G b^G=(ab)^G$ or $a^G b^G$ is the union of at least $\\frac{p+1}{2}$ distinct conjugacy classes. As an application of the previous result, given any nilpotent group $G$ and any conjugacy class...

  4. Reduce Skills Teaching in the Mathematics Class.

    Science.gov (United States)

    Devlin, Keith

    1999-01-01

    Mathematics is much more than a collection of procedures for solving problems. Argues that the primary goal in the mathematics class is to create an awareness of the what, the how, and the why of mathematics. (ASK)

  5. Innovations in Large Classes in Pakistan.

    Science.gov (United States)

    Sarwar, Zakia

    2001-01-01

    Explains innovations taking place in large English-as-a-foreign-language classrooms in Pakistan. Describes a pilot project that investigated ways of bringing out effective learning in large classes. (Author/VWL)

  6. Training Teachers for Mixed Ability Classes

    Science.gov (United States)

    Wragg, E. C.

    1978-01-01

    Discusses the preparation of student teachers for mixed ability classes, based on the Nottingham/Leicester project. Outlines a ten-point attack highlighting the areas in which young teachers need to acquire professional skills. (Author/RK)

  7. Quantum principal bundles and their characteristic classes

    CERN Document Server

    Durdevic, M

    1996-01-01

    A brief exposition of the general theory of characteristic classes of quantum principal bundles is given. The theory of quantum characteristic classes incorporates ideas of classical Weil theory into the conceptual framework of non-commutative differential geometry. A purely cohomological interpretation of the Weil homomorphism is given, together with a standard geometrical interpretation via quantum invariant polynomials. A natural spectral sequence is described. Some quantum phenomena appearing in the formalism are discussed.

  8. Should ESL Classes Never Mention Religion?

    Institute of Scientific and Technical Information of China (English)

    顾炜俊

    2014-01-01

    As religion is an integrated part of human history and culture, an L2 cannot be learnt without some mentioning of it in the language classes. Teaching about religion cannot only help L2 learners learn the L2 itself but other general knowledge such as history, music and arts. However, differences should be made between teaching religion and teaching about religion and some guidelines should be followed if teachers are to teach it in the language classes.

  9. A dual-mode highly efficient class-E stimulator controlled by a low-Q class-E power amplifier through duty cycle.

    Science.gov (United States)

    Chiu, Hung-Wei; Lu, Chien-Chi; Chuang, Jia-min; Lin, Wei-Tso; Lin, Chii-Wann; Kao, Ming-Chien; Lin, Mu-Lien

    2013-06-01

    This paper presents the design flow of two high-efficiency class-E amplifiers for the implantable electrical stimulation system. The implantable stimulator is a high-Q class-E driver that delivers a sine-wave pulsed radiofrequency (PRF) stimulation, which was verified to have a superior efficacy in pain relief to a square wave. The proposed duty-cycle-controlled class-E PRF driver designed with a high-Q factor has two operational modes that are able to achieve 100% DC-AC conversion, and involves only one switched series inductor and an unchanged parallel capacitor. The measured output amplitude under low-voltage (LV) mode using a 22% duty cycle was 0.98 V with 91% efficiency, and under high-voltage (HV) mode using a 47% duty cycle was 2.95 V with 92% efficiency. These modes were inductively controlled by a duty-cycle detector, which can detect the duty-cycle modulated signal generated from the external complementary low-Q class-E power amplifier (PA). The design methodology of the low-Q inductive interface for a non-50% duty cycle is presented. The experimental results exhibits that the 1.5-V PA that consumes DC power of 14.21 mW was able to deliver a 2.9-V sine wave to a 500 Ω load. The optimal 60% drain efficiency of the system from the PA to the load was obtained at a 10-mm coupling distance.

  10. Providing Internet Material in University English Classes

    Institute of Scientific and Technical Information of China (English)

    田巧智

    2004-01-01

    More and more language teachers are finding that the World Wide Web is a treasure chest of authentic language materials and are actively integrating on-line real data and other resources into their classes. This paper mainly focuses on benefits as well as activities of selecting and using Internet material in English classes. It is a good way of motivating students to use English outside the classroom and to make English a part of their daily lives.

  11. Effective Language Teaching in Large Classes

    Institute of Scientific and Technical Information of China (English)

    张丽丽

    2010-01-01

    <正>With more and more people who are jumping into the line of learning the second language (especially English),and also due to the limited resources in language teaching,many foreign language teachers are nowadays confronting the large classes when teaching.So how to teach foreign language effectively in large classes has become an issue as well as a special field to make researches in.

  12. A Class of Bidimensional FMRA Wavelet Frames

    Institute of Scientific and Technical Information of China (English)

    Yun Zhang LI

    2006-01-01

    This paper addresses the construction of wavelet frame from a frame multiresolution analysis (FMRA) associated with a dilation matrix of determinant ±2. The dilation matrices of determinant ±2 can be classified as six classes according to integral similarity. In this paper, for four classes of them, the construction of wavelet frame from an FMRA is obtained, and, as examples, Shannon type wavelet frames are constructed, which have an independent value for their optimality in some sense.

  13. Motivation-stimulating Strategies in English Classes

    Institute of Scientific and Technical Information of China (English)

    李宁

    2015-01-01

    Motivation plays a very important role in foreign language learning. So it becomes worthwhile to study the teachers’ motivation-stimulating strategies. This article mainly discusses two strategies of stimulating the students’motivation in English classes:environment-providing strategies and goal-oriented strategies. They are hoped to provide some references for English teachers to stimulate the students’learning motivation in their classes.

  14. The Complexity Of The NP-Class

    CERN Document Server

    Barron-Romero, Carlos

    2010-01-01

    This paper presents a novel and straight formulation, and gives a complete insight towards the understanding of the complexity of the problems of the so called NP-Class. In particular, this paper focuses in the Searching of the Optimal Geometrical Structures and the Travelling Salesman Problems. The main results are the polynomial reduction procedure and the solution to the Noted Conjecture of the NP-Class.

  15. SSN 774 Virginia Class Submarine (SSN 774)

    Science.gov (United States)

    2015-12-01

    increasing performance capabilities more than eleven years after lead ship delivery in October 2004. With the delivery to the Navy of USS JOHN WARNER (SSN...of VIRGINIA Class Submarines are highlighted by the Commissioning of USS JOHN WARNER (SSN 785) at Norfolk Naval Shipyard on August 1, 2015 and the...significant production milestone with the completion of her pressure hull on August 29, 2015. Other near term VIRGINIA Class program events include Pre

  16. A class of positive atomic maps

    Energy Technology Data Exchange (ETDEWEB)

    Chruscinski, Dariusz; Kossakowski, Andrzej [Institute of Physics, Nicolaus Copernicus University, Grudziadzka 5/7, 87-100 Torun (Poland)

    2008-05-30

    We construct a new class of positive indecomposable maps in the algebra of d x d complex matrices. These maps are characterized by the 'weakest' positivity property and for this reason they are called atomic. This class provides a new rich family of atomic entanglement witnesses which define an important tool for investigating quantum entanglement. It turns out that they are able to detect states with the 'weakest' quantum entanglement.

  17. A class of positive atomic maps

    Science.gov (United States)

    Chruściński, Dariusz; Kossakowski, Andrzej

    2008-05-01

    We construct a new class of positive indecomposable maps in the algebra of d × d complex matrices. These maps are characterized by the 'weakest' positivity property and for this reason they are called atomic. This class provides a new rich family of atomic entanglement witnesses which define an important tool for investigating quantum entanglement. It turns out that they are able to detect states with the 'weakest' quantum entanglement.

  18. Ray class fields of conductor p

    CERN Document Server

    Stadnik, Maria

    2012-01-01

    We prove that (under the assumption of the generalized Riemann hypothesis) a totally real multiquadratic number field K has a positive density of primes p for which the ray class field of conductor p has an explicit description as the Hilbert class field H of K adjoin the real number \\zeta_p + \\zeta_p^{-1} if and only if K contains a unit of norm -1.

  19. WIDTHS AND AVERAGE WIDTHS OF SOBOLEV CLASSES

    Institute of Scientific and Technical Information of China (English)

    刘永平; 许贵桥

    2003-01-01

    This paper concerns the problem of the Kolmogorov n-width, the linear n-width, the Gel'fand n-width and the Bernstein n-width of Sobolev classes of the periodicmultivariate functions in the space Lp(Td) and the average Bernstein σ-width, averageKolmogorov σ-widths, the average linear σ-widths of Sobolev classes of the multivariatequantities.

  20. An Investigation of Craniocervical Posture in Class II & Class III Skeletal Patients

    Directory of Open Access Journals (Sweden)

    T. HoseinZadeh-Nik

    2005-02-01

    Full Text Available Statement of Problem: Craniocervical Posture is a factor in the development and function of Craniofacial Structure. Previous studies of different samples have demonstrated associations between craniocervical posture and craniofacial morphology.Purpose: This study aimed lo examine whether any significant association is evident or not between craniocervical posture and the occurrence of Class il & Class III skeletal malocclusions.Materials and Methods: A sample of 76 subjects with Class II & Class III skeletal malocclusion aged 9-i 1 and>18 years were selected. None of them had received orthodontic treatment. Lateral cephalometric radiographs were taken in natural head position (NHP, and craniocervical and craniohorizental angels were traced and determined for analysis of craniocervical posture. Results: According to the craniocervical posture, most class II skeletal patients have flexed heads and class MI skeletal patients have extended heads, as a result malocclusion in these patients seems to become more severe. With increase in age. class II skeletal patients have more flexed their heads and malocclusion become more severe, while with increase in age in class ill skeletal patients, their heads become extended and once again malocclusion thought lo be more severe. In class II skeletal patients, craniocervical posture has a significant correlation with the vertical growth pattern, but shows little correlation with the horizontal growth pattern. In class 111 skeletal patients, craniocervical posture shows no correlation to any of the vertical & horizontal growth patterns, of course the mean of vertical angles is less in these patients and probably in order to make these relation significant in Class III skeletal patients there is need for more samples, in class II & class III skeletal patients, the amount of Na.prep-point A and pog-Na.prep with craniocervical posture shows a significant correlation. Conclusion: Consideration of craniocervical

  1. CLASS: The Cosmology Large Angular Scale Surveyor

    CERN Document Server

    Essinger-Hileman, Thomas; Amiri, Mandana; Appel, John W; Araujo, Derek; Bennett, Charles L; Boone, Fletcher; Chan, Manwei; Cho, Hsiao-Mei; Chuss, David T; Colazo, Felipe; Crowe, Erik; Denis, Kevin; Dünner, Rolando; Eimer, Joseph; Gothe, Dominik; Halpern, Mark; Harrington, Kathleen; Hilton, Gene; Hinshaw, Gary F; Huang, Caroline; Irwin, Kent; Jones, Glenn; Karakla, John; Kogut, Alan J; Larson, David; Limon, Michele; Lowry, Lindsay; Marriage, Tobias; Mehrle, Nicholas; Miller, Amber D; Miller, Nathan; Moseley, Samuel H; Novak, Giles; Reintsema, Carl; Rostem, Karwan; Stevenson, Thomas; Towner, Deborah; U-Yen, Kongpop; Wagner, Emily; Watts, Duncan; Wollack, Edward; Xu, Zhilei; Zeng, Lingzhen

    2014-01-01

    The Cosmology Large Angular Scale Surveyor (CLASS) is an experiment to measure the signature of a gravita-tional-wave background from inflation in the polarization of the cosmic microwave background (CMB). CLASS is a multi-frequency array of four telescopes operating from a high-altitude site in the Atacama Desert in Chile. CLASS will survey 70\\% of the sky in four frequency bands centered at 38, 93, 148, and 217 GHz, which are chosen to straddle the Galactic-foreground minimum while avoiding strong atmospheric emission lines. This broad frequency coverage ensures that CLASS can distinguish Galactic emission from the CMB. The sky fraction of the CLASS survey will allow the full shape of the primordial B-mode power spectrum to be characterized, including the signal from reionization at low $\\ell$. Its unique combination of large sky coverage, control of systematic errors, and high sensitivity will allow CLASS to measure or place upper limits on the tensor-to-scalar ratio at a level of $r=0.01$ and make a cosmi...

  2. Class I methanol masers: Masers with EGOs

    CERN Document Server

    Chen, Xi; Shen, Zhi-Qiang

    2009-01-01

    We have compared the results of a number of published class I methanol maser surveys with the catalogue of high-mass outflow candidates identified from the GLIMPSE survey (known as extended green objects or EGOs). We find class I methanol masers associated with approximately two-thirds of EGOs. Although the association between outflows and class I methanol masers has long been postulated on the basis of detailed studies of a small number of sources, this result demonstrates the relationship for the first time on a statistical basis. Despite the publication of a number of searches for class I methanol masers, a close physical association with another astrophysical object which could be targeted for the search is still lacking. The close association between class I methanol masers and EGOs therefore provides a large catalogue of candidate sources, most of which have not previously been searched for class I methanol masers. Interstellar masers and outflows have both been proposed to trace an evolutionary sequenc...

  3. CLASS: The Cosmology Large Angular Scale Surveyor

    Science.gov (United States)

    Essinger-Hileman, Thomas; Ali, Aamir; Amiri, Mandana; Appel, John W.; Araujo, Derek; Bennett, Charles L.; Boone, Fletcher; Chan, Manwei; Cho, Hsiao-Mei; Chuss, David T.; Colazo, Felipe; Crowe, Erik; Denis, Kevin; Dunner, Rolando; Eimer, Joseph; Gothe, Dominik; Halpern, Mark; Kogut, Alan J.; Miller, Nathan; Moseley, Samuel; Rostem, Karwan; Stevenson, Thomas; Towner, Deborah; U-Yen, Kongpop; Wollack, Edward

    2014-01-01

    The Cosmology Large Angular Scale Surveyor (CLASS) is an experiment to measure the signature of a gravitational wave background from inflation in the polarization of the cosmic microwave background (CMB). CLASS is a multi-frequency array of four telescopes operating from a high-altitude site in the Atacama Desert in Chile. CLASS will survey 70% of the sky in four frequency bands centered at 38, 93, 148, and 217 GHz, which are chosen to straddle the Galactic-foreground minimum while avoiding strong atmospheric emission lines. This broad frequency coverage ensures that CLASS can distinguish Galactic emission from the CMB. The sky fraction of the CLASS survey will allow the full shape of the primordial B-mode power spectrum to be characterized, including the signal from reionization at low-length. Its unique combination of large sky coverage, control of systematic errors, and high sensitivity will allow CLASS to measure or place upper limits on the tensor-to-scalar ratio at a level of r = 0:01 and make a cosmic-variance-limited measurement of the optical depth to the surface of last scattering, tau. (c) (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

  4. PLGG1, a plastidic glycolate glycerate transporter, is required for photorespiration and defines a unique class of metabolite transporters.

    Science.gov (United States)

    Pick, Thea R; Bräutigam, Andrea; Schulz, Matthias A; Obata, Toshihiro; Fernie, Alisdair R; Weber, Andreas P M

    2013-02-19

    Photorespiratory carbon flux reaches up to a third of photosynthetic flux, thus contributes massively to the global carbon cycle. The pathway recycles glycolate-2-phosphate, the most abundant byproduct of RubisCO reactions. This oxygenation reaction of RubisCO and subsequent photorespiration significantly limit the biomass gains of many crop plants. Although photorespiration is a compartmentalized process with enzymatic reactions in the chloroplast, the peroxisomes, the mitochondria, and the cytosol, no transporter required for the core photorespiratory cycle has been identified at the molecular level to date. Using transcript coexpression analyses, we identified Plastidal glycolate glycerate translocator 1 (PLGG1) as a candidate core photorespiratory transporter. Related genes are encoded in the genomes of archaea, bacteria, fungi, and all Archaeplastida and have previously been associated with a function in programmed cell-death. A mutant deficient in PLGG1 shows WT-like growth only in an elevated carbon dioxide atmosphere. The mutant accumulates glycolate and glycerate, leading to the hypothesis that PLGG1 is a glycolate/glycerate transporter. This hypothesis was tested and supported by in vivo and in vitro transport assays and (18)O(2)-metabolic flux profiling. Our results indicate that PLGG1 is the chloroplastidic glycolate/glycerate transporter, which is required for the function of the photorespiratory cycle. Identification of the PLGG1 transport function will facilitate unraveling the role of similar proteins in bacteria, archaea, and fungi in the future.

  5. AQU-1, a chromosomal class C β-lactamase, among clinical Aeromonas dhakensis isolates: distribution and clinical significance.

    Science.gov (United States)

    Wu, Chi-Jung; Wang, Hsuan-Chen; Chen, Po-Lin; Chang, Ming-Chung; Sunny Sun, H; Chou, Pei-Hsin; Ko, Wen-Chien

    2013-11-01

    Aeromonas dhakensis, a recently described Aeromonas sp. formerly called Aeromonas aquariorum, is associated with human infections. In this study, a chromosomal gene, blaAQU-1, was identified in A. dhakensis AAK1 that constitutes a 1143-bp open reading frame and is 87% identical to the gene encoding CepH in Aeromonas hydrophila. An Escherichia coli TOP10 cell transformant harbouring blaAQU-1 was resistant to cefotaxime but not to cefepime. mRNA expression of blaAQU-1 in the cefotaxime-resistant mutant strain AAK1m was 70-fold higher than in the wild strain AAK1. In all 16 A. dhakensis isolates (the major species of 51 consecutive Aeromonas blood isolates collected from June 1999 to June 2001) as well as in A. aquariorum MDC47(T) and A. hydrophila subsp. dhakensis LMG 19562(T), but not in the reference strains or clinical isolates of other A. hydrophila subspecies, Aeromonas caviae, Aeromonas veronii or Aeromonas enteropelogenes, blaAQU-1-related genes were detected by PCR. Overall, 13 (81%) of the 16 A. dhakensis blood isolates exhibited either cefotaxime resistance or the in vitro emergence of derepressed cefotaxime-resistant mutants. In vivo selection of an A. dhakensis resistant mutant was noted in a burn patient undergoing cefotaxime monotherapy. These observations suggest that AQU-1 is a chromosomal cephalosporinase in A. dhakensis. Cefotaxime monotherapy for severe A. dhakensis infections should be used cautiously.

  6. Intrinsic characteristic classes for a local Lie group

    CERN Document Server

    Abadoglu, Ender

    2009-01-01

    For a local Lie group M we define odd order cohomology classes. The first class is an obstruction to globalizability of the local Lie group. The third class coincides with Godbillon-Vey class in a particular case. These classes are secondary as they emerge when curvature vanishes.

  7. The shape and size of the sella turcica in skeletal Class I, Class II, and Class III Saudi subjects.

    Science.gov (United States)

    Alkofide, Eman A

    2007-10-01

    The purpose of this study was to describe the shape and measure the size of the sella turcica in Saudi subjects with different skeletal types. Lateral cephalometric radiographs of 180 individuals (90 males and 90 females) with an age range of 11-26 years were taken and distributed according to skeletal classification; 60 Class I, 60 Class II, and 60 Class III. The sella turcica on each radiograph was analysed and measured to determine the shape of the sella, in addition to the linear dimensions of length, depth, and diameter. A Student's t-test was used to calculate differences in linear dimensions, while a one-way analysis of variance was performed to study the relationship between skeletal type and sella size. The results show that the sella turcica presented with a normal morphology in the majority of subjects (67 per cent). No significant differences in linear dimensions between genders could be found. When age was evaluated, significant differences were found between the older (15 years or more) and the younger (11-14 years) age groups at the 0.01 and 0.001 levels for length, depth, and diameter. Sella size of the older age group was larger than in the younger age group. When skeletal type was compared with sella size, a significant difference was found in the diameter of sella between the Class II and Class III subjects (P sella turcica area in Saudi subjects.

  8. Structural Properties of MHC Class II Ligands, Implications for the Prediction of MHC Class II Epitopes

    DEFF Research Database (Denmark)

    Jørgensen, Kasper Winther; Buus, Søren; Nielsen, Morten

    2010-01-01

    properties of MHC class II ligands. Here, we perform one such large-scale analysis. A large set of SYFPEITHI MHC class II ligands covering more than 20 different HLA-DR molecules was analyzed in terms of their secondary structure and surface exposure characteristics in the context of the native structure......Major Histocompatibility class II (MHC-II) molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment. Prediction of MHC class II ligands is complicated by the open binding cleft of the MHC class II molecule...... of the corresponding source protein. We demonstrated that MHC class II ligands are significantly more exposed and have significantly more coil content than other peptides in the same protein with similar predicted binding affinity. We next exploited this observation to derive an improved prediction method for MHC...

  9. Dentofacial characteristics of patients with Angle Class I and Class II malocclusions

    Directory of Open Access Journals (Sweden)

    Rogério Lacerda dos Santos

    2012-04-01

    Full Text Available OBJECTIVE: The present study assessed some cephalometric measurements of the soft tissue profile in order to observe the behavior of facial convexity in patients with Class I, Class II division 1, and Class II division 2 malocclusions. METHODS: One hundred and thirty pre-treatment teleradiographs of Caucasian patients aged 10-16 years (mean age of 12.6 years were selected for study and divided into 3 groups. The cephalometric measurements used in the present study were the following: H.SN, Cx, NLA, MLA, UL-SUL-S, LL-S, IMPA, and 1-SN. Analysis of variance and Tukey's test were applied for measurements H.SN, Cx, IMPA, 1-SN, MLA, and NLA, whereas Kruskal-Wallis and Dunn's tests were applied for UL-S and LL-S. RESULTS: The results showed statistically significant differences for the measurements H.SN, Cx, UL-S, and IMPA between Groups I, II-1 and II-2 (p < 0.05. Measurements LL-S and MLA showed statistically significant difference between Groups I and II-1 only (p < 0.05. On the other hand, no statistically significant differences were found for measurement NLA among the 3 groups (p < 0.05. CONCLUSION: Regarding facial characteristics expressed by measurements H.SN, Cx, and UL-S, one could conclude that Class II division 1 and Class II division 2 malocclusions, both differed from Class I malocclusion. In addition, Class II division 1 malocclusion was found to have facial characteristics expressed by MLA, which differentiate it from the Class II division 2 and Class 1 malocclusions. Class I, Class II division 1 and Class II division 2 malocclusions showed no difference in facial characteristics expressed by the measurement NLA, and measurement LL-S was directly related to eversion of the lower lip.

  10. Students' different understandings of class diagrams

    Science.gov (United States)

    Boustedt, Jonas

    2012-03-01

    The software industry needs well-trained software designers and one important aspect of software design is the ability to model software designs visually and understand what visual models represent. However, previous research indicates that software design is a difficult task to many students. This article reports empirical findings from a phenomenographic investigation on how students understand class diagrams, Unified Modeling Language (UML) symbols, and relations to object-oriented (OO) concepts. The informants were 20 Computer Science students from four different universities in Sweden. The results show qualitatively different ways to understand and describe UML class diagrams and the "diamond symbols" representing aggregation and composition. The purpose of class diagrams was understood in a varied way, from describing it as a documentation to a more advanced view related to communication. The descriptions of class diagrams varied from seeing them as a specification of classes to a more advanced view, where they were described to show hierarchic structures of classes and relations. The diamond symbols were seen as "relations" and a more advanced way was seeing the white and the black diamonds as different symbols for aggregation and composition. As a consequence of the results, it is recommended that UML should be adopted in courses. It is briefly indicated how the phenomenographic results in combination with variation theory can be used by teachers to enhance students' possibilities to reach advanced understanding of phenomena related to UML class diagrams. Moreover, it is recommended that teachers should put more effort in assessing skills in proper usage of the basic symbols and models and students should be provided with opportunities to practise collaborative design, e.g. using whiteboards.

  11. Group cohesion in exercise classes: An examination of gender and type of exercise class differences

    Directory of Open Access Journals (Sweden)

    Selçuk Akpınar

    2011-10-01

    Full Text Available Group cohesion has been attributed to the higher levels of attendance and performance and lower levels of drop-outs in exercise classes. Cohesion can be affected by different type of exercise classes and gender. Therefore, the main purpose of the study was to compare the group cohesion levels of martial arts participants (aikido, taekwondo, karate, and kendo with aerobic-like participants (aerobics, aero-steps, phys-gym, and high-low aerobics. This causal comparative study also aimed at examining gender differences in group cohesion in exercise classes. There were 140 participants (Mage=28.1 SD= 8.01 and female= 138 male= 2 in aerobic-like classes and 137 participants (Mage= 22.2 SD= 3.8 and female= 48 male= 89 in martial arts classes. Results revealed no gender differences between the groups on the perceptions of cohesion. On the other hand, except for individual attractions to the group-task dimension, participants of martial art classes had higher levels of group cohesion than the participants of aerobic-like classes. Consequently, it was concluded that different types of exercise classes may have different levels of cohesion and those differences were discussed within the context of exercise classes

  12. Group cohesion in exercise classes: An examination of gender and type of exercise class differences

    Directory of Open Access Journals (Sweden)

    Hülya Aşçı

    2011-10-01

    Full Text Available Group cohesion has been attributed to the higher levels of attendance and performance and lower levels of drop-outs in exercise classes. Cohesion can be affected by different type of exercise classes and gender. Therefore, the main purpose of the study was to compare the group cohesion levels of martial arts participants (aikido, taekwondo, karate, and kendo with aerobic-like participants (aerobics, aero-steps, phys-gym, and high-low aerobics. This causal comparative study also aimed at examining sex differences in group cohesion in exercise classes. There were 140 participants (Mage=28.1 SD= 8.01 and female= 138 male= 2 in aerobic-like classes and 137 participants (Mage= 22.2 SD= 3.8 and female= 48 male= 89 in martial arts classes. Results revealed no sex differences between the groups on the perceptions of cohesion. On the other hand, except for individual attractions to the group-task dimension, participants of martial art classes had higher levels of group cohesion than the participants of aerobic-like classes. Consequently, it was concluded that different types of exercise classes may have different levels of cohesion and those differences were discussed within the context of exercise classes.

  13. Evaluation depth of the curve of Spee in class I, class II, and class III malocclusion: A cross sectional study

    Directory of Open Access Journals (Sweden)

    Sanjna Nayar

    2015-01-01

    Full Text Available Occlusal plane is an essential consideration when multiple long-span posterior restorations are designed. When restorations are added to an existing tooth arrangement characterized by rotated, tipped, or extruded teeth, excursive interferences may be incorporated, resulting in detrimental squeal. The curve of Spee, which exists in the ideal natural dentition, allows harmony to exist between the anterior tooth and condylar guidance. This curve exists in the sagittal plane and is the best viewed from a lateral aspect. It permits total posterior disclusion on mandibular protrusion, given proper anterior tooth guidance. It is unclear that whether the curve of Spee is a description of the occlusal surface of each arch separately or in maximal intercuspation. The purpose of this study was to examine the differences in the depth of curve of Spee between the class I, class II, class III and to investigate the relationship of depth of curve of Spee with over jet, over-bite.

  14. Main: PE2FNTRNR1A [PLACE

    Lifescience Database Archive (English)

    Full Text Available PE2FNTRNR1A S000455 29-November-2004 (last modified) kehi pE2F (proximal E2F elemen...of the cell cycle; Important for regulating specific RNR1a (ribonucleotide reductase large subunit) gene exp

  15. Fibonacci family of dynamical universality classes.

    Science.gov (United States)

    Popkov, Vladislav; Schadschneider, Andreas; Schmidt, Johannes; Schütz, Gunter M

    2015-10-13

    Universality is a well-established central concept of equilibrium physics. However, in systems far away from equilibrium, a deeper understanding of its underlying principles is still lacking. Up to now, a few classes have been identified. Besides the diffusive universality class with dynamical exponent [Formula: see text], another prominent example is the superdiffusive Kardar-Parisi-Zhang (KPZ) class with [Formula: see text]. It appears, e.g., in low-dimensional dynamical phenomena far from thermal equilibrium that exhibit some conservation law. Here we show that both classes are only part of an infinite discrete family of nonequilibrium universality classes. Remarkably, their dynamical exponents [Formula: see text] are given by ratios of neighboring Fibonacci numbers, starting with either [Formula: see text] (if a KPZ mode exist) or [Formula: see text] (if a diffusive mode is present). If neither a diffusive nor a KPZ mode is present, all dynamical modes have the Golden Mean [Formula: see text] as dynamical exponent. The universal scaling functions of these Fibonacci modes are asymmetric Lévy distributions that are completely fixed by the macroscopic current density relation and compressibility matrix of the system and hence accessible to experimental measurement.

  16. Social class, anxieties and mothers' foodwork.

    Science.gov (United States)

    Wright, Jan; Maher, JaneMaree; Tanner, Claire

    2015-03-01

    In the context of concerns about childhood obesity, mothers are placed at the forefront of responsibility for shaping the eating behaviour and consequently the health of their young children. This is evident in a multitude of diverse sites such as government reports, health promotion materials, reality TV shows and the advice of childcare nurses and preschools. These sites produce a range of resources available to mothers to draw on to constitute themselves as mothers in terms of caring for their children's health. Drawing on a qualitative study of mothers recruited through three Australian preschool centres, this article examines how the working-class and middle-class mothers of preschool-aged children engage with knowledge about motherhood, children and health and how those engagements impact on their mothering, their foodwork and their children. We argue that, unlike the working-class mothers pathologised in some literature on obesity, these working-class mothers demonstrated a no-nonsense (but still responsibilised) approach to feeding their children. The middle-class mothers, on the other hand, were more likely to engage in practices of self-surveillance and to demonstrate considerable anxieties about the appropriateness of their practices for their children's current and future health.

  17. Software engineering processes for Class D missions

    Science.gov (United States)

    Killough, Ronnie; Rose, Debi

    2013-09-01

    Software engineering processes are often seen as anathemas; thoughts of CMMI key process areas and NPR 7150.2A compliance matrices can motivate a software developer to consider other career fields. However, with adequate definition, common-sense application, and an appropriate level of built-in flexibility, software engineering processes provide a critical framework in which to conduct a successful software development project. One problem is that current models seem to be built around an underlying assumption of "bigness," and assume that all elements of the process are applicable to all software projects regardless of size and tolerance for risk. This is best illustrated in NASA's NPR 7150.2A in which, aside from some special provisions for manned missions, the software processes are to be applied based solely on the criticality of the software to the mission, completely agnostic of the mission class itself. That is, the processes applicable to a Class A mission (high priority, very low risk tolerance, very high national significance) are precisely the same as those applicable to a Class D mission (low priority, high risk tolerance, low national significance). This paper will propose changes to NPR 7150.2A, taking mission class into consideration, and discuss how some of these changes are being piloted for a current Class D mission—the Cyclone Global Navigation Satellite System (CYGNSS).

  18. Researcher perspectives on class size reduction.

    Directory of Open Access Journals (Sweden)

    Elizabeth Graue

    2009-05-01

    Full Text Available This article applies to class size research Grant and Graue’s (1999 position that reviews of research represent conversations in the academic community. By extending our understanding of the class size reduction conversation beyond published literature to the perspectives of researchers who have studied the topic, we create a review that includes political histories of, contextual details about, and assumptions undergirding the conversation. We find divergent (and sometimes competing perspectives on identifying beneficiaries of class size reduction (or CSR and the correct context in which to view CSR research. By contrasting the logic and assumptions embedded in pupil-teacher ratio (PTR, class size (CS, and class size reduction studies, we conclude that sometimes research conflates these constructs and their associated theories of action, and such distortion poorly serves the needs of policymakers and stakeholders in education. We recommend that future inquiry focus on mechanisms of change, particularly instruction—both in terms of instructional strategies that capitalize on the resource of a smaller group and the types of support needed for teacher and administrator professional development.

  19. The Cosmology Large Angular Scale Surveyor (CLASS)

    Science.gov (United States)

    Harrington, Kathleen; Marriange, Tobias; Aamir, Ali; Appel, John W.; Bennett, Charles L.; Boone, Fletcher; Brewer, Michael; Chan, Manwei; Chuss, David T.; Colazo, Felipe; Denis, Kevin; Moseley, Samuel H.; Rostem, Karwan; Wollack, Edward

    2016-01-01

    The Cosmology Large Angular Scale Surveyor (CLASS) is a four telescope array designed to characterize relic primordial gravitational waves from in ation and the optical depth to reionization through a measurement of the polarized cosmic microwave background (CMB) on the largest angular scales. The frequencies of the four CLASS telescopes, one at 38 GHz, two at 93 GHz, and one dichroic system at 145/217 GHz, are chosen to avoid spectral regions of high atmospheric emission and span the minimum of the polarized Galactic foregrounds: synchrotron emission at lower frequencies and dust emission at higher frequencies. Low-noise transition edge sensor detectors and a rapid front-end polarization modulator provide a unique combination of high sensitivity, stability, and control of systematics. The CLASS site, at 5200 m in the Chilean Atacama desert, allows for daily mapping of up to 70% of the sky and enables the characterization of CMB polarization at the largest angular scales. Using this combination of a broad frequency range, large sky coverage, control over systematics, and high sensitivity, CLASS will observe the reionization and recombination peaks of the CMB E- and B-mode power spectra. CLASS will make a cosmic variance limited measurement of the optical depth to reionization and will measure or place upper limits on the tensor-to-scalar ratio, r, down to a level of 0.01 (95% C.L.).

  20. COMMUNICATION AND INTERACTION IN ART CLASSES

    Directory of Open Access Journals (Sweden)

    Maja Hrvanović

    2014-01-01

    Full Text Available Numerous indicators affect communication and interaction in art classes. For every teacher, as pedagogue, his successful educational activity is very important as some indicators influence the two-way exchange of information in art classes. Teaching art is very specific way of teaching process, because it is mostly based on exchange of visual information of artistic type which represents a special form of communication. The specificity of artistic information, way of acting on the viewer and intense emotional charge in the process of communication should be used as visual stimulus. The richness of imagery, stimulation of reality, abstraction and other cognitive processes in art classes experientially and visually improve students’ awareness and should be represented and diversified by origin and multiplied by quantity. The research paper aims to demonstrate the importance of connectivity between judgment of taste and ability to evaluate the quality of the work of art in art and non-art schools. Teaching and education in art classes is being realized precisely inside communicative relations and appropriate socio-emotional climate. In this research, visual communication in art classes is defined over the structure of the inventory that will examine the differences between abilities to evaluate the quality of artistic information and the judgment of taste.

  1. Communicative Language Teaching in Second Language Class

    Institute of Scientific and Technical Information of China (English)

    Xiao Juan

    2010-01-01

    IntroductionReturn the class to the students and let the students be the masters of the class.This is what I have changed during the last three years in my class.I have been using Communicative Language Teaching method instead of Grammar Translation method.In the Grammar Translation method, students only study grammar and learn lists of words and then translate what they have learned into Chinese.In the classroom,the teacher uses the students' first language to explain the grammar and vocabulary in the text and then helps the students to translate it.This method is based on the idea that language is made up of words and that language changes according to the grammar rules.

  2. Novamene: A new class of carbon allotropes

    Directory of Open Access Journals (Sweden)

    Larry A Burchfield

    2017-02-01

    Full Text Available We announce a new class of carbon allotropes. The basis of this new classification resides on the concept of combining hexagonal diamond (sp3 bonded carbon − lonsdaleite and ring carbon (sp2 bonded carbon − graphene. Since hexagonal diamond acts as an insulator and sp2 bonded rings act as conductors, these predicted materials have potential applications for transistors and other electronic components. We describe the structure of a proposed series of carbon allotropes, novamene, and carry out a detailed computational analysis of the structural and electronic properties of the simplest compound in this class: the single-ring novamene. In addition, we suggest how hundreds of different allotropes of carbon could be constructed within this class.

  3. THE LYGEO-STIPETEA CLASS IN SICILY

    Directory of Open Access Journals (Sweden)

    C. BRULLO

    2010-04-01

    Full Text Available Basing on literature data and unpublished relevés from Sicily, a survey of the syntaxa belonging to the class Lygeo-Stipetea Rivas-Martínez 1978 is presented. This perennial vegetation is characterized by the dominance of big caespitose hemicryptophytes, and it is widely distributed in Sicily from the sea level up to 1500 m a.s.l. The class is represented in Sicily by two orders, floristically and ecologically well differentiated: Lygeo-Stipetalia, including the sole alliance Moricandio-Lygeion exclusively of clayey substrates, and Hyparrhenietalia hirtae, including five alliances (Hyparrhenion hirtae, Avenulo cincinnatae-Ampelodesmion mauritanici, Thero-Brachypodion ramosi, Bromo-Oryzopsion miliaceae, and Arundion collinae occurring on various substrates. Within the class, 50 associations have been recognized. To support the syntaxonomic proposal, a multivariate numerical analysis, considering literature and personal data, has been performed. Nomenclature, floristic settlement, ecology, syndynamism and chorology are examined for each syntaxon.

  4. TEACHERS’ ROLES IN THE EXTENSIVE READING CLASS

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Ⅰ. Introduction. Today, in most English teaching classes, owing to the popularity of the student-centered teaching approach, the traditional teacher-centered teaching approach has gradually lost its dominating place. As far as extensive reading classes are concerned, this is no exception. The more communicative student-centered approach has been popularly adopted. As a result, the teachers’ roles in the reading classes are changing accordingly. A qualified teacher should be prepared to take different roles at different stages of teaching. Jeremy Harmer has pointed out that a teacher can be expected to act, for example, as a controller, an assessor, an organizer, a prompter, a participant and as a resource (Harmer, 1983). In this

  5. Evolution of Class III treatment in orthodontics.

    Science.gov (United States)

    Ngan, Peter; Moon, Won

    2015-07-01

    Angle, Tweed, and Moyers classified Class III malocclusions into 3 types: pseudo, dentoalveolar, and skeletal. Clinicians have been trying to identify the best timing to intercept a Class III malocclusion that develops as early as the deciduous dentition. With microimplants as skeletal anchorage, orthopedic growth modification became more effective, and it also increased the scope of camouflage orthodontic treatment for patients who were not eligible for orthognathic surgery. However, orthodontic treatment combined with orthognathic surgery remains the only option for patients with a severe skeletal Class III malocclusion or a craniofacial anomaly. Distraction osteogenesis can now be performed intraorally at an earlier age. The surgery-first approach can minimize the length of time that the malocclusion needs to worsen before orthognathic surgery. Finally, the use of computed tomography scans for 3-dimensional diagnosis and treatment planning together with advances in imaging technology can improve the accuracy of surgical movements and the esthetic outcomes for these patients.

  6. Preventing Academic Dishonesty in Online Classes

    Institute of Scientific and Technical Information of China (English)

    薛淑娟; 孙童真

    2015-01-01

    Abstract:The purpose of this paper is to look into the manner of cheating in online course environment and explore the prevention measures to stop cheating. This paper is designed to address two research questions: 1) What are the types of cheating happening in online classes from the perspectives of instructors or students in online classes? 2) What are preventive measures to stop cheating in online classes? The questionnaire used in this research tests the prevalence of academic dishonesty and the methods of cheating in online courses. Data will be collected through a survey from students who take online course during the 2013 spring semester. This paper will present practical suggestions to reduce the frequency of cheating among students enrolling in online courses.

  7. Middle Class and Democracy in Latin America

    Directory of Open Access Journals (Sweden)

    Jaime Fierro

    2015-06-01

    Full Text Available The consolidation of the middle class has been interpreted by modernization and postmodernization theories as a key factor for the functioning and stability of the democratic system. However, in Latin America the middle class has tended to be associated with two contradictory positions. On the one hand, it is emphasized that it plays a stabilizing and democratic role while, on the other hand, it is linked to supporting military coups. With the purpose of elucidate such a dilemma, the relationship that can be established between the socioeconomic status and the degree of support for democracy will be examined. In order to do this, an empirical analysis from Latinbarometer surveys databases will be conducted, covering seventeen countries in the region for the period from 1996 to 2011. It will be concluded that the middle class in Latin America does not have particularly more favorable attitudes toward democracy than other social segments.

  8. The MHC class I genes of zebrafish.

    Science.gov (United States)

    Dirscherl, Hayley; McConnell, Sean C; Yoder, Jeffrey A; de Jong, Jill L O

    2014-09-01

    Major histocompatibility complex (MHC) molecules play a central role in the immune response and in the recognition of non-self. Found in all jawed vertebrate species, including zebrafish and other teleosts, MHC genes are considered the most polymorphic of all genes. In this review we focus on the multi-faceted diversity of zebrafish MHC class I genes, which are classified into three sequence lineages: U, Z, and L. We examine the polygenic, polymorphic, and haplotypic diversity of the zebrafish MHC class I genes, discussing known and postulated functional differences between the different class I lineages. In addition, we provide the first comprehensive nomenclature for the L lineage genes in zebrafish, encompassing at least 15 genes, and characterize their sequence properties. Finally, we discuss how recent findings have shed new light on the remarkably diverse MHC loci of this species.

  9. The Elusive New Middle Class in Brazil

    Directory of Open Access Journals (Sweden)

    Celia Lessa Kerstenetzky

    2015-12-01

    Full Text Available Against the background of the generalized reduction of poverty in the world, and particularly in Brazil, this article intends to gauge the socio-economic profile of Brazilian households that emerged from poverty and have been identified as integrating a "new middle class". Using indicators of standards of living from the 2008-2009 Survey on Family Budgets (POF/IBGE, we found out that, in contrast to what has been assumed on the basis of average income criteria, this social stratum is markedly heterogeneous, most of it being similar in their consumption patterns to the economically vulnerable or outright poor strata. So, we conclude that, from a sociological perspective that demands additional conditions besides income levels to identify social classes, it is a category mistake to call this social stratum a new middle class. We conjecture that this may be consequential in terms of policy priorities and choices.

  10. Comparison of Group Cohesion, Class Participation, and Exam Performance in Live and Online Classes

    Science.gov (United States)

    Galyon, Charles E.; Heaton, Eleanore C. T.; Best, Tiffany L.; Williams, Robert L.

    2016-01-01

    Though class participation and group cohesion have shown some potential to promote student performance in conventional classrooms, their efficacy has not yet been demonstrated in an online-class setting. Group cohesion, defined as member attraction to and self-identification with a group, is thought to promote positive interdependence and the…

  11. Linking Classes: Learning Communities, "High" Culture, and the Working Class Student

    Science.gov (United States)

    Rodriguez, Ginger G.; Buczinsky, Christopher

    2013-01-01

    How do you teach the humanities to working class students living in the shadow of a BP oil refinery? Calumet College uses freshman learning communities that link humanities, social justice, and English composition classes to provide a foundation for college success to predominantly first-generation students who are often underprepared for…

  12. Vulnerability and social class : Differential patterns of personality and social support over the social classes

    NARCIS (Netherlands)

    Ranchor, AV; Bouma, J; Sanderman, R

    1996-01-01

    One of the most consistent findings in epidemiologic research is a negative relation between social class and health. Health complaints are generally more common in the lower social classes. Psychosocial, together with material, cultural and behavioral factors, are among those factors, which could e

  13. Classes and Theories of Trees Associated with a Class Of Linear Orders

    DEFF Research Database (Denmark)

    Goranko, Valentin; Kellerman, Ruaan

    2011-01-01

    Given a class of linear order types C, we identify and study several different classes of trees, naturally associated with C in terms of how the paths in those trees are related to the order types belonging to C. We investigate and completely determine the set-theoretic relationships between thes...

  14. Generalized Design Equations for Class-E Power Amplifiers with Finite DC Feed Inductance

    NARCIS (Netherlands)

    Acar, M.; Annema, A.J.; Nauta, B.

    2006-01-01

    In literature, it is widely accepted that the design of Class-E Power Amplifier (PA) with finite dc feed inductance requires a long iterative solution procedure. To avoid such iterative solution methods, analytical design equations should be known. The problem associated with the finite dc feed indu

  15. 75 FR 51171 - Amendment of Class D and Class E Airspace; Kaneohe, HI

    Science.gov (United States)

    2010-08-19

    ... Administration 14 CFR Part 71 Amendment of Class D and Class E Airspace; Kaneohe, HI AGENCY: Federal Aviation... E airspace at Kaneohe Bay Marine Corps Air Station (MCAS), Kaneohe, HI. The FAA is taking this... upward from 700 feet above the surface at Kaneohe Bay MCAS, Kaneohe Bay, HI. The geographic...

  16. 76 FR 9266 - Proposed Amendment of Class D and Class E Airspace; Idaho Falls, ID

    Science.gov (United States)

    2011-02-17

    ... Falls, ID AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to amend the Class D and Class E airspace areas at Idaho Falls, ID, by changing the name of the airport to Idaho Falls Regional Airport, and adjusting the...

  17. 75 FR 49866 - Proposed Amendment of Class D and Class E Airspace; Klamath Falls, OR

    Science.gov (United States)

    2010-08-16

    ... Falls, OR AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to amend Class D and Class E airspace at Klamath Falls, OR. Decommissioning of the Merrill Non-Directional Radio Beacon (NDB) at Klamath Falls Airport has made this...

  18. SOME REFLECTIONS ABOUT LEADING LARGE CLASSES

    Directory of Open Access Journals (Sweden)

    GIOVANY SUÁREZ PINILLA

    2016-07-01

    Full Text Available This article provides some strategies for teachers to deal with large classes having into account that this is a very common situation in different educational levels. Some teaching methods that have been used to make significant progress in the learning and teaching process are presented here, with the aim of getting more efficient and effective educational environment. Under these circumstances, teachers need to assure that they provide an interactive learning environment to their students. Finally, a lesson plan example for a mathematics class considering all these aspects is presented at the end of this paper.

  19. Designing a new class of distributed systems

    CERN Document Server

    Mikkilineni, Rao

    2011-01-01

    Designing a New Class of Distributed Systems closely examines the Distributed Intelligent Managed Element (DIME) Computing Model, a new model for distributed systems, and provides a guide to implementing Distributed Managed Workflows with High Reliability, Availability, Performance and Security. The book also explores the viability of self-optimizing, self-monitoring autonomous DIME-based computing systems. Designing a New Class of Distributed Systems is designed for practitioners as a reference guide for innovative distributed systems design. Researchers working in a related field will also f

  20. An Analysis on an ESL Class

    Institute of Scientific and Technical Information of China (English)

    杜岳青

    2015-01-01

    Input is the precondition of interaction and output while output promotes the input and the interaction of language,which could increase the effectiveness of input and enhance the chance of the absorption of interaction.By analyzing an ESL class,this paper gives readers a picture of how the second language (SL) learners get information,absorb and digest the information,produce language and form their language system in their SL learning.At last,it gives suggestions on how to ensure language learners have a better chance to get comprehensible input,assimilate language during interaction and output more accurate and comprehensible second language in an ESL class.

  1. Type Classes for Lightweight Substructural Types

    Directory of Open Access Journals (Sweden)

    Edward Gan

    2015-02-01

    Full Text Available Linear and substructural types are powerful tools, but adding them to standard functional programming languages often means introducing extra annotations and typing machinery. We propose a lightweight substructural type system design that recasts the structural rules of weakening and contraction as type classes; we demonstrate this design in a prototype language, Clamp. Clamp supports polymorphic substructural types as well as an expressive system of mutable references. At the same time, it adds little additional overhead to a standard Damas-Hindley-Milner type system enriched with type classes. We have established type safety for the core model and implemented a type checker with type inference in Haskell.

  2. Class IIa bacteriocins: diversity and new developments.

    Science.gov (United States)

    Cui, Yanhua; Zhang, Chao; Wang, Yunfeng; Shi, John; Zhang, Lanwei; Ding, Zhongqing; Qu, Xiaojun; Cui, Hongyu

    2012-12-06

    Class IIa bacteriocins are heat-stable, unmodified peptides with a conserved amino acids sequence YGNGV on their N-terminal domains, and have received much attention due to their generally recognized as safe (GRAS) status, their high biological activity, and their excellent heat stability. They are promising and attractive agents that could function as biopreservatives in the food industry. This review summarizes the new developments in the area of class IIa bacteriocins and aims to provide uptodate information that can be used in designing future research.

  3. Class IIa Bacteriocins: Diversity and New Developments

    Science.gov (United States)

    Cui, Yanhua; Zhang, Chao; Wang, Yunfeng; Shi, John; Zhang, Lanwei; Ding, Zhongqing; Qu, Xiaojun; Cui, Hongyu

    2012-01-01

    Class IIa bacteriocins are heat-stable, unmodified peptides with a conserved amino acids sequence YGNGV on their N-terminal domains, and have received much attention due to their generally recognized as safe (GRAS) status, their high biological activity, and their excellent heat stability. They are promising and attractive agents that could function as biopreservatives in the food industry. This review summarizes the new developments in the area of class IIa bacteriocins and aims to provide uptodate information that can be used in designing future research. PMID:23222636

  4. Education, class and vernacular awareness on Tyneside

    DEFF Research Database (Denmark)

    Jensen, Marie Møller

    2017-01-01

    This paper reports on a questionnaire study investigating Tyneside residents’ vernacular awareness and attested language use. Participant performance is interpreted on the basis of a cross-tabulation of participants’ social class as determined by their level of education and participants’ own....... This group consisted of mainly older female speakers and results are interpreted in light of first wave studies on the patterning of language use by class, age and gender. Finally, the issue of vernacular awareness is linked to social indexicality and it is suggested that an interpretation of participants...

  5. A class of symmetric controlled quantum operations

    CERN Document Server

    Vaccaro, J A; Huelga, S F; Vaccaro, John A.

    2001-01-01

    Certain quantum gates, such as the controlled-NOT gate, are symmetric in terms of the operation of the control system upon the target system and vice versa. However, no operational criteria yet exist for establishing whether or not a given quantum gate is symmetrical in this sense. We consider a restricted, yet broad, class of two-party controlled gate operations for which the gate transforms a reference state of the target into one of an orthogonal set of states. We show that for this class of gates it is possible to establish a simple necessary and sufficient condition for the gate operation to be symmetric.

  6. A class of symmetric controlled quantum operations

    Energy Technology Data Exchange (ETDEWEB)

    Vaccaro, John A.; Steuernagel, O.; Huelga, S.F. [Division of Physics and Astronomy, Department of Physical Sciences, University of Hertfordshire, Hatfield (United Kingdom)

    2001-09-07

    Certain quantum gates, such as the controlled-NOT gate, are symmetric in terms of the operation of the control system upon the target system and vice versa. However, no operational criteria yet exist for establishing whether or not a given quantum gate is symmetrical in this sense. We consider a restricted, yet broad, class of two-party controlled gate operations for which the gate transforms a reference state of the target into one of an orthogonal set of states. We show that for this class of gates it is possible to establish a simple necessary and sufficient condition for the gate operation to be symmetric. (author)

  7. Class IIa Bacteriocins: Diversity and New Developments

    Directory of Open Access Journals (Sweden)

    Yanhua Cui

    2012-12-01

    Full Text Available Class IIa bacteriocins are heat-stable, unmodified peptides with a conserved amino acids sequence YGNGV on their N-terminal domains, and have received much attention due to their generally recognized as safe (GRAS status, their high biological activity, and their excellent heat stability. They are promising and attractive agents that could function as biopreservatives in the food industry. This review summarizes the new developments in the area of class IIa bacteriocins and aims to provide uptodate information that can be used in designing future research.

  8. Software extension and integration with type classes

    DEFF Research Database (Denmark)

    Lämmel, Ralf; Ostermann, Klaus

    2006-01-01

    expressiveness, by using the language concept of \\emph{type classes}, as it is available in the functional programming language Haskell. A detailed comparison with related work shows that type classes provide a powerful framework in which solutions to known software extension and integration problems can......The abilities to extend a software module and to integrate a software module into an existing software system without changing existing source code are fundamental challenges in software engineering and programming-language design. We reconsider these challenges at the level of language...

  9. Student impressions of an art therapy class.

    Science.gov (United States)

    Hensel, Desiree; Bradburn, Taylor Caitlin; Kelly, Amy; Manahan, Isabel; Merriman, Hannah; Metzinger, Faith; Moore, Heather

    2012-12-01

    Art therapy facilitates the expression of thoughts and feelings and thus may serve as a self-care strategy. This paper describes the implementation of an expressive art therapy class to teach self-care during a required sophomore level nursing wellness course and the outcomes of the class through the eyes of six students. While students were initially reluctant to engage in the activity, the shared stories revealed feelings of relaxation, empowerment, value clarification, and increased self-awareness. The implication for nursing education is that the integration of art therapy into curricula may serve as an effective strategy to teaching self-care and core professional values.

  10. The Application of Hedges in EFL Class

    Institute of Scientific and Technical Information of China (English)

    闫志军

    2016-01-01

    Hedges, as a common linguistic phenomenon, are used in daily communication to make sure that the communication can move on smoothly and to attain specific goals by speakers. If the hedges are used properly in class, they could make talks between teacher and students become more polite, flexible and effective and facilitate effective teaching and learning. Based on the writer's past experience, this paper intends to analyze the specific application and pragmatic functions of hedges used by both teacher and students in EFL class.

  11. A New Class of Random Number Generators

    OpenAIRE

    Marsaglia, George; Zaman, Arif

    1991-01-01

    We introduce a new class of generators of two types: add-with-carry and subtract-with-borrow. Related to lagged-Fibonacci generators, the new class has interesting underlying theory, astonishingly long periods and provable uniformity for full sequences. Among several that we mention, we recommend particularly promising ones that will generate a sequence of $2^{1751}$ bits, or a sequence of $2^{1376}$ 32-bit integers, or a sequence of $2^{931}$ reals with 24-bit fractions--all using simple com...

  12. Class Size and Cost in ADN Programs

    Science.gov (United States)

    Boehret, Alice C.; Larowe, Ann

    1978-01-01

    The article discusses the cost-effective use of faculty and facilities in associate degree nursing programs, as a large number of programs with small classes is uneconomical. Appraisal of admissions to reach an enrollment level sufficient to justify program cost is suggested. (MF)

  13. Using Poetry with Mixed Ability Language Classes.

    Science.gov (United States)

    Tomlinson, Brian

    1986-01-01

    Discusses the value of using poetry to teach English as a second language to mixed ability classes. Lists the following criteria for selecting poems: (1) universal appeal; (2) surface simplicity, (3) potential depth, (4) affective potential, (5) contemporary language, (6) brevity, and (7) potential for illustration. Describes ways of using two…

  14. The Class of 2011 Student Survey Report

    Science.gov (United States)

    National Association of Colleges and Employers (NJ3), 2011

    2011-01-01

    Based on responses from 20,000 college seniors nationwide, "The Class of 2011 Student Survey Report" gives you hard numbers "plus" the analysis you need to develop your college recruiting strategy and build your brand among college students. Align your recruiting strategies tactics with students' wants, needs, attitudes, and behaviors--you'll get…

  15. Alternative Class Ranks Using Z-Scores

    Science.gov (United States)

    Brown, Philip H.; Van Niel, Nicholas

    2012-01-01

    Grades at US colleges and universities have increased precipitously over the last 50 years, suggesting that their signalling power has become attenuated. Moreover, average grades have risen disproportionately in some departments, implying that weak students in departments with high grades may obtain better class ranks than strong students in…

  16. Conjugacy classes in discrete Heisenberg groups

    Energy Technology Data Exchange (ETDEWEB)

    Budylin, R Ya [Steklov Mathematical Institute of Russian Academy of Sciences (Russian Federation)

    2014-08-01

    We study an extension of a discrete Heisenberg group coming from the theory of loop groups and find invariants of conjugacy classes in this group. In some cases, including the case of the integer Heisenberg group, we make these invariants more explicit. Bibliography: 4 titles.

  17. Cultural Consciousness in a Language Class.

    Science.gov (United States)

    Banerjee, Haimanti

    1997-01-01

    Acknowledging that the Suggestopedia approach is not very popular, this paper focuses on the use of Suggestopedia's distinctive features to promote awareness of the linguistic and cultural features of the target culture in a language class. The role of the classroom environment in this approach is also examined. The context considered here is a…

  18. Using Video Conferencing in Lecture Classes

    Science.gov (United States)

    Gibbs, Bill; Larson, Erik

    2007-01-01

    Duquesne University's department of journalism and multimedia arts supports many of its classes with Mediasite Live, a video conferencing system that captures the output of presentation devices and streams it live to the Web, as well as recording presentations for Web streaming or recording to CD or DVD. Bill Gibbs and Erik Larson examine the…

  19. Technology Uptake in Chinese EFL Classes

    Science.gov (United States)

    Li, Li; Walsh, Steve

    2011-01-01

    This article presents findings from what we believe to be the first large-scale study of its kind on the use of ICT (information and communications technology) in English language classes in China. Participants are 400 EFL (English as a foreign language) teachers from different types of schools in Beijing. The purpose of the study was to examine…

  20. Small Group Multitasking in Literature Classes

    Science.gov (United States)

    Baurain, Bradley

    2007-01-01

    Faced with the challenge of teaching American literature to large, multilevel classes in Vietnam, the writer developed a flexible small group framework called "multitasking". "Multitasking" sets up stable task categories which rotate among small groups from lesson to lesson. This framework enabled students to work cooperatively…

  1. Teaching Dystopian Literature to a Consumer Class

    Science.gov (United States)

    Wilkinson, Rachel

    2010-01-01

    Many students are struggling with more depression and anxiety than ever before. These are characteristic dangers of the "consumer class"--1.7 billion people worldwide who are "characterized by diets of highly processed food, desire for bigger houses, more and bigger cars, higher levels of debt, and lifestyles devoted to the accumulation of…

  2. Cyclic cohomology and characteristic classes for foliations

    NARCIS (Netherlands)

    Crainic, M.

    2001-01-01

    This thesis deals with the cohomology theories and the theory of characteristic classes for leaf spaces of foliations, as well as with the interaction between the classical approach (of Grothendieck, Bott-Haefliger) and the non-commutative approach (of Connes-Moscovici) to these theories. Leaf

  3. Stability of latent class segments over time

    DEFF Research Database (Denmark)

    Mueller, Simone

    2011-01-01

    Dynamic stability, as the degree to which identified segments at a given time remain unchanged over time in terms of number, size and profile, is a desirable segment property which has received limited attention so far. This study addresses the question to what degree latent classes identified from...

  4. Class Generation for Numerical Wind Atlases

    DEFF Research Database (Denmark)

    Cutler, N.J.; Jørgensen, B.H.; Ersbøll, Bjarne Kjær;

    2006-01-01

    A new optimised clustering method is presented for generating wind classes for mesoscale modelling to produce numerical wind atlases. It is compared with the existing method of dividing the data in 12 to 16 sectors, 3 to 7 wind-speed bins and dividing again according to the stability of the atmos......A new optimised clustering method is presented for generating wind classes for mesoscale modelling to produce numerical wind atlases. It is compared with the existing method of dividing the data in 12 to 16 sectors, 3 to 7 wind-speed bins and dividing again according to the stability...... of the atmosphere. Wind atlases are typically produced using many years of on-site wind observations at many locations. Numerical wind atlases are the result of mesoscale model integrations based on synoptic scale wind climates and can be produced in a number of hours of computation. 40 years of twice daily NCEP....../NCAR reanalysis geostrophic wind data (approximately 200 km resolution) are represented in typically around 150 classes, each with a frequency of occurrence. The mean wind-speed and direction in each class is used as input data to force the mesoscale model, which downscales the wind to a 5 km resolution while...

  5. The Audiolingual Method in Intensive Reading Class

    Institute of Scientific and Technical Information of China (English)

    张晓辉

    2010-01-01

    The Audiolingual Method consists of four steps:recognition,repetition,pattern drills and follow-up reading. The article is about the use of the Audiolingual Method in intensive reading class through the experiment of the students from grade one to grade two.

  6. Institutional Support Infrastructure for Online Classes.

    Science.gov (United States)

    Schroeder, Ray

    2001-01-01

    Asserting that providing infrastructure to support online classes is analogous to building a new physical campus adjacent to the pre-existing one, describes the support requirements of online faculty, information technology networks, students, and administrators. Says that if these infrastructure considerations are not addressed near the beginning…

  7. The Teaching of Speaking in Big Classes

    Directory of Open Access Journals (Sweden)

    Ruwandi Ruwandi

    2016-07-01

    Full Text Available Speaking is the most important language skill. The language user’s capability will be immediately understood and measured through the skill because this is the most visible proficiency. Difficulties of teaching speaking vary dependent upon the class size. Teaching speaking in big classes is more difficult than teaching of it in small classes. The main constraint is the time allotment. To answer the problem, speaking teachers should be creative to set the intensive classroom activities. If this is true, they need to identify students speaking skill to understand their alertness for the following language instructions. Besides that, they are also responsible to identify their basic need in the class whether this is only for question and answer, dialog, discussion, debate, or others. To anticipate the time constraints, the teachers engage to select the possible methods and strategies for presenting the interesting instructional materials. At the end, teachers should divide the time allotment adjust and proportionally for their students so they are able to self-express and share ideas in those interactive classroom situations.

  8. A new class of spontaneously polarized materials

    DEFF Research Database (Denmark)

    Field, David; Plekan, Oksana; Cassidy, Andrew;

    2011-01-01

    Very large electric fields form spontaneously within films of seemingly prosaic chemicals such as nitrous oxide or propane.We describe how the discovery of this unexpected phenomenon took place and how we attempt to understand the nature of the new class of spontaneously polarized materials, rese...

  9. Northwest Introduces Its New World Business Class

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>Northwest Airlines today unveiled several major enhancements to its international World Business Class product, providing its premium customers in the Asia Pacific region with a new lie-flat bed seat and state-of-the-art inflight entertainment system.In addition the carrier announced chanaes to its world

  10. Feng Yun-A higher Class

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    TO this Weiqi player, rising to a higher class is like climbing a mountain. Hangzhou city is a lucky place for Feng Yun for it is where she won her first national championship 10 years ago. Commonly known by it's Japanese name "Go", Weiqi is actually of Chinese origin and is a game of

  11. On Online Assignments in a Calculus Class

    Science.gov (United States)

    Jungic, Veselin; Kent, Deborah; Menz, Petra

    2012-01-01

    In this paper, we describe our experience with the creation and utilization of online assignments for several calculus classes at Simon Fraser University (SFU). We present our findings regarding available software by considering the needs and perspectives of the instructors, students, and administrators. We provide a list of questions that guide…

  12. Incorporating Sociology into Community Service Classes

    Science.gov (United States)

    Hochschild, Thomas R., Jr.; Farley, Matthew; Chee, Vanessa

    2014-01-01

    Sociologists and instructors who teach about community service share an affinity for understanding and addressing social problems. While many studies have demonstrated the benefits of incorporating community service into sociology courses, we examine the benefits of incorporating sociological content into community service classes. The authors…

  13. First-class rules and generic traversal

    NARCIS (Netherlands)

    Dolstra, E.; Visser, Eelco

    2002-01-01

    In this paper we present a functional language supporting first-class rules and generic traversal. This is achieved by generalizing the pattern matching constructs of standard functional languages. The case construct that ties rules together and prevents their reuse, is replaced by separate, firstcl

  14. Finite mutation classes of coloured quivers

    CERN Document Server

    Torkildsen, Hermund André

    2010-01-01

    We consider the general notion of coloured quiver mutation and show that the mutation class of a coloured quiver $Q$, arising from an $m$-cluster tilting object associated with $H$, is finite if and only if $H$ is of finite or tame representation type, or it has at most 2 simples. This generalizes a result known for 1-cluster categories.

  15. Disseny d'un amplificador classe D

    OpenAIRE

    Sangüesa Cremades, Kevin

    2010-01-01

    Diseny i muntatge en circuit imprés d'un amplificador commutat classe D. Disseny i testeig dels subsistemes i muntatge i verificació final. Permet treballar amb electrònica analògica i amb commutada, i amb dispositius de potencia mitjana. Potencia de sortida (aprox): 5 - 10 W.

  16. Measuring the Community in Online Classes

    Science.gov (United States)

    Rubin, Beth; Fernandes, Ronald

    2013-01-01

    This paper proposes both theoretical and empirical approaches to differentiating the community of inquiry (CoI) in online classes at individual and group levels. Following the example of research on organizational climate, it assesses the strength of shared perceptions of teaching presence, social presence, and cognitive presence. The paper…

  17. BDDCS Class Prediction for New Molecular Entities

    DEFF Research Database (Denmark)

    Broccatelli, Fabio; Cruciani, Gabriele; Benet, Leslie Z.;

    2012-01-01

    descriptors calculated or derived from the VolSurf+ software. For each molecule, a probability of BDDCS class membership was given, based on predicted EoM, FDA solubility (FDAS) and their confidence scores. The accuracy in predicting FDAS was 78% in training and 77% in validation, while for EoM prediction...

  18. Apply the Communicative Approach in Listening Class

    Institute of Scientific and Technical Information of China (English)

    Wang; changxue; Su; na

    2014-01-01

    Speaking and listening are the two obstacles in the process of our learning and they are also the most important abilities that we should possess. Communicative approach aims to the ability of learners’ communicative competence, thus apply the communicative approach in listening class is an effective way in English teaching procedure.

  19. Apply the Communicative Approach in Listening Class

    Institute of Scientific and Technical Information of China (English)

    Wang changxue; Su na

    2014-01-01

    Speaking and listening are the two obstacles in the process of our learning and they are also the most important abilities that we should possess. Communicative approach aims to the ability of learners’communicative competence, thus apply the communicative approach in listening class is an effective way in English teaching procedure.

  20. Inclusive Classes in Physical Education: Teachers' Difficulties

    Science.gov (United States)

    Toloi, Gabriela Gallucci; Manzini, Eduardo José; Spoldaro, Diego Machado; Zacarias, Lucas Ventura

    2016-01-01

    The successful inclusion of students with special needs in physical education classes requires much planning and preparation. Lack of preparation of physical education teachers working in inclusive settings in Brazil has demonstrated the need for specialized training in strategies for implementing inclusion. The goal of this study was to identify,…

  1. Small Group Multitasking in Literature Classes

    Science.gov (United States)

    Baurain, Bradley

    2007-01-01

    Faced with the challenge of teaching American literature to large, multilevel classes in Vietnam, the writer developed a flexible small group framework called "multitasking". "Multitasking" sets up stable task categories which rotate among small groups from lesson to lesson. This framework enabled students to work cooperatively in a variety of…

  2. Application of Body Language in Primary Class

    Institute of Scientific and Technical Information of China (English)

    张宁宁

    2011-01-01

    Body language is an essential medium for people to communicate in their daily life. The use of body language has positive effects on teachers' teaching and on students' learning as well, so we strongly advocate teachers to integrate body language into primary class skilfully.

  3. How to Use Body Language in Class

    Institute of Scientific and Technical Information of China (English)

    李毅

    2006-01-01

    @@ With the reform of language teaching and learning methods, teachers should use more English in class. However, with the limitation of students' vccabulary, teachers have to simplify their teaching language with the help of body language, which has perceptual and potential power, influencing the students' knowledge,emotion.character, ideology, etc.

  4. A new class of non-leaves

    CERN Document Server

    Souza, Fábio S

    2011-01-01

    We give examples of open smooth manifolds that cannot be leaves of any Riemannian foliation of arbitrary codimension on a compact manifold. We also present a new class of non-leaves of C^0 codimension one foliations, simply connected manifolds of dimension at least 5 that are non-periodic in homotopy, namely in their 2-dimensional homotopy groups.

  5. World class manufacturing in metallurgical enterprise

    Directory of Open Access Journals (Sweden)

    B. Gajdzik

    2013-01-01

    Full Text Available World Class Manufacturing (WCM assumes increase of efficiency of the company by elimination of all the losses, wastage and dangers of safety. In ArcelorMittal the concept of WCM is implemented in particular enterprises within the capital group. In this publication the activities conducted in some of those enterprises are described.

  6. Using Nonverbal Communication in Efl Classes

    Directory of Open Access Journals (Sweden)

    Aysenil Barabar

    2015-06-01

    Full Text Available This paper aims at providing information about nonverbal communication and to state its use in EFL classes. Briefly, this paper introduces the definition, aspects and importance of nonverbal communication. Especially, this study explains some ways of using nonverbal communication in EFL classes, in order to have good classroom management in the class. Based upon this assumption, we aimed to shed light on this area of research, by showing that teachers’ nonverbal behaviour plays a highly significant and essential role in foreign language classrooms for managing the students’ behaviour. This study was conducted in Lefke, Northern Cyprus. The participants were two female English language teachers who were working at the English Preparatory School of Lefke. The study was qualitative in design and the data was gathered through interviews and reflective reports. A triangulation technique was used to enhance confidence in the ensuing findings. Cross-case analysis was used to examine and identify common themes between the cases. The results showed that nonverbal communication has a pivotal role in classroom management. In EFL classes in Northern Cyprus, in order to guide teachers to use nonverbal communication before verbal communication, some seminars or workshops should be organized regarding the use of body language in classroom management to improve teachers professionally.

  7. From State Diagram to Class Diagram

    DEFF Research Database (Denmark)

    Borch, Ole; Madsen, Per Printz

    2009-01-01

    UML class diagram and Java source code are interrelated and Java code is a kind of interchange format. Working with UML state diagram in CASE tools, a corresponding xml file is maintained. Designing state diagrams is mostly performed manually using design patterns and coding templates - a time...

  8. Increasing Class Participation in Social Phobic Students

    Science.gov (United States)

    Miranda, Michael V.

    2008-01-01

    The "Find Your Classroom Voice Program" has been offered at Kingsborough Community College for the past three years. Its purpose is to enable students who are consistently inactive in class discussions (and who might be called "classroom-specific social phobic") to develop the ability to take a more active role in the classroom. With its success,…

  9. The Language of Class and Nation

    Science.gov (United States)

    Genovese, Eugene D.

    1975-01-01

    Discusses the nature and history of black English, arguing that the duality of the black experience both within and without the American national experience, and the contribution of different classes and strata of the black community to that duality, appeared in the kind of English spoken on the farms and plantations and in the towns and cities.…

  10. The Promise of Single-Sex Classes

    Science.gov (United States)

    Stotsky, Sandra

    2012-01-01

    Despite the enthusiasm and the absence of definitive research on the pros and cons of single-sex classes, a 2011 article in Science, titled "The Pseudoscience of Single-Sex Schooling," by a new organization called American Council for CoEducational Schooling (ACCES) came out with the astonishing conclusion that single-sex education is…

  11. Culture Teaching in English Language Classes

    Institute of Scientific and Technical Information of China (English)

    Wu Qixuan; Zhao Shuncai

    2007-01-01

    Language is closely related to culture. Language expresses and embodies cultural reality, in the meantime, culture exerts enormous influences on language. Therefore, language learning is often culture learning. The author, based on the negligence of culture teaching in English language classes, illustrates the influences of cultural knowledge on reading, translating and intercultural communicating, and proposes suggestions on culture teaching in English language teaching (ELT).

  12. On identifiability of certain latent class models.

    NARCIS (Netherlands)

    van Wieringen, W.N.

    2005-01-01

    Blischke [1962. Moment estimators for the parameters of a mixture of two binomial distributions. Ann. Math. Statist. 33, 444-454] studies a mixture of two binomials, a latent class model. In this article we generalize this model to a mixture of two products of binomials. We show when this generalize

  13. Developing Reading Competence in University ESL Classes.

    Science.gov (United States)

    Brown, Ronald L.

    A discussion of reading instruction in college English-as-a-Second-Language (ESL) classes presents an overview of reading instruction theory, looks at the role of reading strategies and metacognitive awareness in reading, describes the SQ3R study skills method of instruction, and examines how the method can be used for developing independent…

  14. Online Discussion Assignments Improve Students' Class Preparation

    Science.gov (United States)

    Lineweaver, Tara T.

    2010-01-01

    To increase the number of students who read the text before class and to promote student interaction centering on text material, I developed an online discussion assignment as a required component of a cognitive psychology course. Across 2 studies, this assignment had a limited effect on examination performance, but students completing online…

  15. From Atiyah Classes to Homotopy Leibniz Algebras

    Science.gov (United States)

    Chen, Zhuo; Stiénon, Mathieu; Xu, Ping

    2016-01-01

    A celebrated theorem of Kapranov states that the Atiyah class of the tangent bundle of a complex manifold X makes T X [-1] into a Lie algebra object in D + ( X), the bounded below derived category of coherent sheaves on X. Furthermore, Kapranov proved that, for a Kähler manifold X, the Dolbeault resolution {Ω^{bullet-1}(T_X^{1, 0})} of T X [-1] is an L ∞ algebra. In this paper, we prove that Kapranov's theorem holds in much wider generality for vector bundles over Lie pairs. Given a Lie pair ( L, A), i.e. a Lie algebroid L together with a Lie subalgebroid A, we define the Atiyah class α E of an A-module E as the obstruction to the existence of an A- compatible L-connection on E. We prove that the Atiyah classes α L/ A and α E respectively make L/ A[-1] and E[-1] into a Lie algebra and a Lie algebra module in the bounded below derived category {D^+(A)} , where {A} is the abelian category of left {U(A)} -modules and {U(A)} is the universal enveloping algebra of A. Moreover, we produce a homotopy Leibniz algebra and a homotopy Leibniz module stemming from the Atiyah classes of L/ A and E, and inducing the aforesaid Lie structures in {D^+(A)}.

  16. Utilization of Social Media in Marketing Classes

    Science.gov (United States)

    Allen, Charlotte

    2013-01-01

    The goal of this paper is to highlight how instructors may integrate the different social media into various marketing classes. The paper will address the major social networks, and then follow with discussions of microblogging, media sites, and social gaming. Given that there is a great deal of research highlighting the effectiveness of utilizing…

  17. Using Comic Strips in Language Classes

    Science.gov (United States)

    Csabay, Noémi

    2006-01-01

    The author believes that using comic strips in language-learning classes has three main benefits. First, comic strips motivate younger learners. Second, they provide a context and logically connected sentences to help language learning. Third, their visual information is helpful for comprehension. The author argues that comic strips can be used in…

  18. Social Class, Family Background and Intergenerational Mobility

    DEFF Research Database (Denmark)

    D. Munk, Martin; McIntosh, James

    is proposed and tested using Danish sample survey data that was first collected in 1976 and augmented in 2000. This is referred to as a homogeneity test and is a likelihood ratio test of a set of linear restrictions which define social classes. For Denmark it is shown that this test fails for an Erikson...

  19. Class, Mothering and the Values of Food

    DEFF Research Database (Denmark)

    Aamann, Iben Charlotte

    2015-01-01

    The data analysed in this empirical paper stems from ethnographic fieldwork among new school parents at three Danish primary schools. I draw on empirically grounded theories on the cultural and subjective dimensions of class, inspired by the “English School” of poststructuralist informed, feminist...

  20. The CLASS blazar survey - II. Optical properties

    NARCIS (Netherlands)

    Caccianiga, A; Marcha, MJ; Anton, S; Mack, KH; Neeser, MJ

    2002-01-01

    This paper presents the optical properties of the objects selected in the CLASS blazar survey. Because an optical spectrum is now available for 70 per cent of the 325 sources present in the sample, a spectral classification, based on the appearance of the emission/absorption lines, is possible. A wi

  1. Class II malocclusion occlusal severity description

    Directory of Open Access Journals (Sweden)

    Guilherme Janson

    2010-08-01

    Full Text Available OBJECTIVES: It is well known that the efficacy and the efficiency of a Class II malocclusion treatment are aspects closely related to the severity of the dental anteroposterior discrepancy. Even though, sample selection based on cephalometric variables without considering the severity of the occlusal anteroposterior discrepancy is still common in current papers. In some of them, when occlusal parameters are chosen, the severity is often neglected. The purpose of this study is to verify the importance given to the classification of Class II malocclusion, based on the criteria used for sample selection in a great number of papers published in the orthodontic journal with the highest impact factor. MATERIAL AND METHODS: A search was performed in PubMed database for full-text research papers referencing Class II malocclusion in the history of the American Journal of Orthodontics and Dentofacial Orthopedics (AJO-DO. RESULTS: A total of 359 papers were retrieved, among which only 72 (20.06% papers described the occlusal severity of the Class II malocclusion sample. In the other 287 (79.94% papers that did not specify the anteroposterior discrepancy severity, description was considered to be crucial in 159 (55.40% of them. CONCLUSIONS: Omission in describing the occlusal severity demands a cautious interpretation of 44.29% of the papers retrieved in this study.

  2. JAVA CLASSES FOR NONPROCEDURAL VARIOGRAM MONITORING

    Science.gov (United States)

    A set of Java classes was written for variogram modeling to support research for US EPA's Regional Vulnerability Assessment Program (ReVA). The modeling objectives of this research program are to use conceptual programming tools for numerical analysis for regional risk assessm...

  3. Classroom Management Challenges in the Dance Class

    Science.gov (United States)

    Clark, Dawn

    2007-01-01

    Teaching dance can be a challenge because of the unique classroom-management situations that arise from the dynamic nature of the class content. Management is a delicate navigation of advance planning; rule setting; the establishment and implementation of daily protocols, routines, and interventions; and the teacher's own presentation. This…

  4. Group Work vs. Whole Class Activity

    Science.gov (United States)

    Tanveer, Asma

    2008-01-01

    Group work has only been recently introduced in the education system of Pakistan but many primary teachers, especially in the public schools, are still not aware of how different kinds of strategies that is group work and whole class teaching facilitate learning among students. This paper aims to provide an overview of teaching strategies to…

  5. GPS queues with heterogeneous traffic classes

    NARCIS (Netherlands)

    Borst, Sem; Mandjes, Michel; Uitert, van Miranda

    2002-01-01

    We consider a queue fed by a mixture of light-tailed and heavy-tailed traffic. The two traffic classes are served in accordance with the generalized processor sharing (GPS) discipline. GPS-based scheduling algorithms, such as weighted fair queueing (WFQ), have emerged as an important mechanism for a

  6. Can Gamification Be Introduced within Primary Classes?

    Science.gov (United States)

    Marín, Veronica; López, Magdalena; Maldonado, Guadalupe

    2015-01-01

    Training through gamification is everyday a more evident reality in Primary Education classes. The teachers' view about this has been modified as it is shown in the study published by aDeSe in 2012. However, does it really have place in the students' curricular development in the primary education stage? For the sake of responding to this…

  7. Removing the Caste System from English Classes.

    Science.gov (United States)

    Stocky, Rosemarie

    Outlining an alternative to the basic English classes that segregate slower learning students from their peers, this booklet describes the English Skills Program for ninth graders at Parkway North High School in Creve Coeur, Missouri. Following an introduction explaining the origins of the program, the first two sections describe the program's…

  8. Economies of Scale and Large Classes

    Science.gov (United States)

    Saiz, Martin

    2014-01-01

    Making classes larger saves money--and public universities across the country have found it a useful strategy to balance their budgets after decades of state funding cuts and increases to infrastructure costs. Where this author teaches, in the College of Social and Behavioral Sciences at California State University, Northridge (CSUN),…

  9. Observers for a Class of Chaotic Systems

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ping

    2006-01-01

    The design of observers for a class of practical physical chaotic systems is discussed.By using only one state variable and its time derivatives,a control law is constructed to achieve the synchronization between the investigated chaotic systems and their observers,and the results are proved theoretically.Several observers of chaotic systems are designed by using this method.

  10. Contrasting evolutionary histories of MHC class I and class II loci in grouse—Effects of selection and gene conversion

    Science.gov (United States)

    Minias, Piotr; Bateson, Zachary W; Whittingham, Linda A; Johnson, Jeff A.; Oyler-McCance, Sara J.; Dunn, Peter O

    2016-01-01

    Genes of the major histocompatibility complex (MHC) encode receptor molecules that are responsible for recognition of intracellular and extracellular pathogens (class I and class II genes, respectively) in vertebrates. Given the different roles of class I and II MHC genes, one might expect the strength of selection to differ between these two classes. Different selective pressures may also promote different rates of gene conversion at each class. Despite these predictions, surprisingly few studies have looked at differences between class I and II genes in terms of both selection and gene conversion. Here, we investigated the molecular evolution of MHC class I and II genes in five closely related species of prairie grouse (Centrocercus and Tympanuchus) that possess one class I and two class II loci. We found striking differences in the strength of balancing selection acting on MHC class I versus class II genes. More than half of the putative antigen-binding sites (ABS) of class II were under positive or episodic diversifying selection, compared with only 10% at class I. We also found that gene conversion had a stronger role in shaping the evolution of MHC class II than class I. Overall, the combination of strong positive (balancing) selection and frequent gene conversion has maintained higher diversity of MHC class II than class I in prairie grouse. This is one of the first studies clearly demonstrating that macroevolutionary mechanisms can act differently on genes involved in the immune response against intracellular and extracellular pathogens.

  11. 7 CFR 1160.110 - Class I price.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Class I price. 1160.110 Section 1160.110 Agriculture... and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order Definitions § 1160.110 Class I price. Class I price is the price that is established for Class I milk in...

  12. Understanding the Quality of Out-of-Class English Learning

    Science.gov (United States)

    Lai, Chun; Zhu, Weimin; Gong, Gang

    2015-01-01

    Out-of-class learning constitutes an important context for human development, and active engagement in out-of-class activities is associated with successful language development. However, not all out-of-class experiences are equally beneficial to learning, and it is of paramount importance to understand what quality out-of-class English language…

  13. Using Storytelling Strategies to Improve Student Comprehension in Online Classes

    Science.gov (United States)

    Powell, Rasby Marlene; Murray, Ottis

    2012-01-01

    Previous research shows that presenting class material in story formats can improve student learning in lecture classes. This pilot study of eight sociology classes investigates the efficacy of using storytelling as a means to improve student comprehension in online classes. Our findings show that when material is presented in story format rather…

  14. Social Class in English Language Education in Oaxaca, Mexico

    Science.gov (United States)

    López-Gopar, Mario E.; Sughrua, William

    2014-01-01

    This article explores social class in English-language education in Oaxaca, Mexico. To this end, first, we discuss social class in Mexico as related to coloniality; second, for illustration, the paper presents the authors' own social-class analysis as language educators in Oaxaca; third, we discuss how social class impacts English education…

  15. 46 CFR 50.30-20 - Class III pressure vessels.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Class III pressure vessels. 50.30-20 Section 50.30-20... Fabrication Inspection § 50.30-20 Class III pressure vessels. (a) Class III pressure vessels shall be subject... specifically exempted by other regulations in this subchapter. (b) For Class III welded pressure vessels,...

  16. 25 CFR 502.4 - Class III gaming.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Class III gaming. 502.4 Section 502.4 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GENERAL PROVISIONS DEFINITIONS OF THIS CHAPTER § 502.4 Class III gaming. Class III gaming means all forms of gaming that are not class I gaming or...

  17. 25 CFR 522.12 - Revocation of class III gaming.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Revocation of class III gaming. 522.12 Section 522.12 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR APPROVAL OF CLASS II AND CLASS III ORDINANCES AND RESOLUTIONS SUBMISSION OF GAMING ORDINANCE OR RESOLUTION § 522.12 Revocation of class...

  18. Laptop Use during Class: A Review of Canadian Universities

    Science.gov (United States)

    Cismaru, Romulus; Cismaru, Magdalena

    2011-01-01

    Laptop use in class is a characteristic of universities that is changing rapidly. Although much of the attention and research regarding this issue has focused on the debate of whether to impose mandatory laptop programs, the reality of wireless campuses allows students to use their laptops in class for class related and non-class related…

  19. Social Class in English Language Education in Oaxaca, Mexico

    Science.gov (United States)

    López-Gopar, Mario E.; Sughrua, William

    2014-01-01

    This article explores social class in English-language education in Oaxaca, Mexico. To this end, first, we discuss social class in Mexico as related to coloniality; second, for illustration, the paper presents the authors' own social-class analysis as language educators in Oaxaca; third, we discuss how social class impacts English education…

  20. 7 CFR 1610.9 - Class B stock.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Class B stock. 1610.9 Section 1610.9 Agriculture... POLICIES § 1610.9 Class B stock. Borrowers receiving loans from the Bank shall be required to invest in class B stock at 5 percent of the total amount of loan funds advanced. Borrowers may purchase class...

  1. A two-age-classes dengue transmission model

    NARCIS (Netherlands)

    Supriatna, A.K.; Soewono, E.; Gils, van S.A.

    2008-01-01

    In this paper, we discuss a two-age-classes dengue transmission model with vaccination. The reason to divide the human population into two age classes is for practical purpose, as vaccination is usually concentrated in one age class. We assume that a constant rate of individuals in the child-class i

  2. Group Projects in Interior Design Studio Classes: Peer Feedback Benefits

    Science.gov (United States)

    Jurado, Juan A.

    2011-01-01

    Group projects have been shown to be effective for providing peer feedback in classrooms. While students in regular enrollment classes benefit from peer feedback, low-enrollment classes face many challenges. This study compares peer feedback effectiveness between two interior design studio classes with different design projects. In one class,…

  3. Atrial Fibrillation During an Exploration Class Mission

    Science.gov (United States)

    Lipset, Mark A.; Lemery, Jay; Polk, J. D.; Hamilton, Douglas R.

    2010-01-01

    Background: A long-duration exploration class mission is fraught with numerous medical contingency plans. Herein, we explore the challenges of symptomatic atrial fibrillation (AF) occurring during an exploration class mission. The actions and resources required to ameliorate the situation, including the availability of appropriate pharmaceuticals, monitoring devices, treatment modalities, and communication protocols will be investigated. Challenges of Atrial Fibrillation during an Exploration Mission: Numerous etiologies are responsible for the initiation of AF. On Earth, we have the time and medical resources to evaluate and determine the causative situation for most cases of AF and initiate therapy accordingly. During a long-duration exploration class mission resources will be severely restricted. How is one to determine if new onset AF is due to recent myocardial infarction, pulmonary embolism, fluid overload, thyrotoxicosis, cardiac structural abnormalities, or CO poisoning? Which pharmaceutical therapy should be initiated and what potential side effects can be expected? Should anti-coagulation therapy be initiated? How would one monitor the therapeutic treatment of AF in microgravity? What training would medical officers require, and which communication strategies should be developed to enable the best, safest therapeutic options for treatment of AF during a long-duration exploration class mission? Summary: These questions will be investigated with expert opinion on disease elucidation, efficient pharmacology, therapeutic monitoring, telecommunication strategies, and mission cost parameters with emphasis on atrial fibrillation being just one illustration of the tremendous challenges that face a long-duration exploration mission. The limited crew training time, medical hardware, and drugs manifested to deal with such an event predicate that aggressive primary and secondary prevention strategies be developed to protect a multibillion-dollar asset like the

  4. THE WORKING CLASS, THE EMERGENCE OF THE CLASS CONSCIOUSNESS AND EDUCATION

    Directory of Open Access Journals (Sweden)

    Paulino José Orso

    2011-12-01

    Full Text Available This article deals with the class society, the emergence of the working class, its recognition as such and the education. Starts with a brief discussion of the positivist and materialist conceptions of society and historical dialectics, following, discusses the tests made by the working class in its long history to win his consciousness to another. If, from ancient times we live in a class society, this period is not the consciousness of belonging to a class of workers and much less for an action based on and consistent with this membership. This achievement goes through several times and struggles, whether against the nobility and aristocracy or against the bourgeoisie, who rub shoulders with many struggles to overthrow the forces of the Old Regime. However, these struggles the working class was also realizing that if the bourgeoisie, at various times, was interested in making alliances incidental to the conquest of power, definitely had no interest in sharing it. Thus, in the successive struggles and betrayals of the bourgeoisie, the working class was learning not only not believe in the promises and illusions of his former "comrades", but also claim the right to give the direction of their lives and "their destination".

  5. The Effects of Class-Specific Histone Deacetylase Inhibitors on the Development of Limbs During Organogenesis.

    Science.gov (United States)

    Paradis, France-Hélène; Hales, Barbara F

    2015-11-01

    Histone deacetylases (HDACs) play a major role in chromatin remodeling, gene regulation, and cellular signaling. While the role of each class of HDAC during normal development is unclear, several HDAC inhibitors are embryotoxic; the mechanisms leading to the teratogenicity of HDAC inhibitors are not known. Here, we investigated the effects of class-specific HDAC inhibitors on the development of organogenesis-stage murine limbs. Timed-pregnant COL2A1-ECFP, COL10A1-mCherry, and COL1A1-YFP CD1 reporter mice were euthanized on gestation day 12; embryonic forelimbs were excised and cultured in vitro for 1, 3, and 6 days in the presence or absence of MS275 (a class I HDAC inhibitor), MC1568 (a class III HDAC inhibitor), Sirtinol (a class II HDAC inhibitor), or valproic acid, our positive control. Fluorescently tagged COL2A1, COL10A1, and COL1A1 served as markers of the differentiation of proliferative chondrocytes, hypertrophic chondrocytes, and osteoblasts, respectively. MS275 and valproic acid caused a reduction in expression of all three markers, suggesting effects on both chondrogenesis and osteogenesis. MC1568 had no effect on chondrocyte markers and mildly inhibited COL1A1 expression at 6 days. Sirtinol had no effect on COL2A1 expression or chondrocyte differentiation 1 day following exposure; however, it caused a drastic regression in limb cartilage and reduced the expression of all three differentiation markers to nearly undetectable levels at 6 days. MS275 and Sirtinol caused a 2.2- and 2.7-fold increase, respectively, in cleaved-caspase 3, a marker of apoptosis, suggesting embryotoxicity. These data demonstrate that inhibition of class I or III HDACs causes severe developmental toxicity and is highly teratogenic.

  6. Classes, cultura e ação coletiva Classes, culture and collective action

    OpenAIRE

    Brasílio Sallum Jr.

    2005-01-01

    O artigo faz uma revisão da literatura sobre classes e conflito social, analisando seus impasses. Em seguida, faz uma incursão aos legados de Pierre Bordieu e Marx sobre a matéria, indicando como poderiam ser integrados numa teoria renovada das classes sociais.The article surveys the literature on class and social conflict, focusing its theoretical dilemmas. Then it discusses Pierre Bordieu's and Marx's legacies on the subject, pointing out how they could be integrated in a renewed theory of ...

  7. Mini-Cluster on Teaching about the 1%, the Rich, the Upper Class, the Ruling Class

    Directory of Open Access Journals (Sweden)

    Marcial González

    2015-02-01

    Full Text Available Marcial González, Greg Meyerson, and Richard Ohmann worked together on these three articles. We spoke on a panel organized by the Radical Caucus of the Modern Language Association for MLA's 2014 convention. Our topic was “Teaching About the 1%, the Rich, the Upper Class, the Ruling Class . . . . " As that list suggests, we meant to explore common ways of conceptualizing the wealthiest people in the U. S., and in capitalist society generally. We argued that the best way is to see them structurally, as integral to a class system. And we sketched out ways for teachers to do that.

  8. 7 CFR 1007.51 - Class I differential, adjustments to Class I prices, and Class I price.

    Science.gov (United States)

    2010-01-01

    ... adjustments: State Country/parish FIPS Class I price adjustment AL AUTAUGA 01001 0.50 AL BALDWIN 01003 0.50 AL... BACON 13005 1.15 GA BAKER 13007 0.85 GA BALDWIN 13009 0.70 GA BANKS 13011 0.70 GA BARROW 13013 0.70 GA... LA SAINT HELENA 22091 0.30 LA SAINT JAMES 22093 0.20 LA SAINT JOHN THE BAPTIST 22095 0.20 LA...

  9. Patrol Vessels «Condestable Zaragoza» Class, Patrol Boats V-class and Antisubmarine Boats LAS-class

    Directory of Open Access Journals (Sweden)

    Valentin Ruesga Herreros

    2016-09-01

    Full Text Available It’s consider information about the number of ships of the Spanish fleet, that not reflected in the available literature. It’s proved that the Spanish patrol vessels of «Condestable Zaragoza»-class and French auxiliary minesweepers «Fanfaron»-classare one the same ships. The conclusion is made based on comparisons of appearance and performance of ships. There was renovated list of patrol boats V-class, shows that their history can be divided into three main stages: the first, when the boats belonged to the Secretariat militarized protection, information about boats are extremely sketchy and incomplete, the second – their inclusion in the fleet, when the information about the service enough full, but almost previous history is not reflected, and only the third stage, when the change came a new generation of boats old boats, often with the same numbers, the story is full enough. An attempt to reconstruction of the biography of LAS-class boats, it is assumed that this former Soviet boat, put the Republicans during the Civil War.

  10. Analytical Design Equations for Class-E Power Amplifiers with Finite DC-Feed Inductance and Switch On-Resistance

    NARCIS (Netherlands)

    Acar, Mustafa; Annema, Anne Johan; Nauta, Bram

    2007-01-01

    Many critical design trade-offs of the class-E power amplifier (e.g power efficiency) are influenced by the switch on-resistance and the value of dc-feed drain inductance. In literature, the time-domain mathematical analyses of the class-E power amplifier with finite dc-feed inductance assume zero s

  11. Conservative compensatory Angle Class III malocclusion treatment

    Directory of Open Access Journals (Sweden)

    Marcio Costa Sobral

    2012-12-01

    Full Text Available INTRODUCTION: Angle's Class III malocclusion is a dental discrepancy in a sagittal view that may appear or not with an important skeletal discrepancy. Facial esthetics may be affected by this skeletal discrepancy and it is one of the most common complaints of patients who seek orthodontic treatment. Class III treatment, in adults, may be done by compensatory tooth movement, in simple cases, or through an association between orthodontics and orthognathic surgery, in more severe cases. OBJECTIVE: This article describes a non-extraction compensatory Class III treatment case, applying the Tweed-Merrifield mechanical principles with headgear (J-Hook in the mandibular arch. This case was presented at the V Brazilian Association of Orthodontics and Dentofacial Orthopedics (ABOR Meeting, it was evaluated by members of Brazilian Board of Orthodontics and obtained third place in the general classification.INTRODUÇÃO: a má oclusão de Classe III se caracteriza por uma desarmonia dentária anteroposterior, podendo estar ou não acompanhada por discrepâncias esqueléticas. A estética facial pode se apresentar comprometida, em maior ou menor grau, a depender da magnitude da discrepância, constituindo um dos principais fatores motivadores da procura por tratamento ortodôntico. O tratamento da Classe III em pacientes adultos pode ser realizado mediante compensação dentária, nos casos mais simples, ou, em situações mais severas, mediante a associação entre Ortodontia e Cirurgia Ortognática. OBJETIVO: o presente artigo objetiva relatar um caso clínico caracterizado por uma má oclusão de Classe III de Angle, tratado de forma compensatória, com extração dos terceiros molares inferiores, mediante a utilização de aparelhagem extrabucal na arcada inferior (J-hook, aplicando-se princípios da técnica de Tweed-Merrifield. Esse caso foi apresentado no 5º Congresso da Associação Brasileira de Ortodontia e Ortopedia Facial (ABOR, na categoria

  12. 2000 Johnston Site 1A-P

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 1A-P was established at Johnston Atoll by Dr. James Maragos, U.S. Fish & Wildlife Service, on June 29, 2000. With a start point (meter 0) at...

  13. 2006 Johnston Site 1A-P

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 1A-P was established at Johnston Atoll by Dr. James Maragos, U.S. Fish & Wildlife Service, on June 29, 2000. With a start point (meter 0) at...

  14. μ-Theraphotoxin-An1a

    DEFF Research Database (Denmark)

    Rates, Breno; Prates, Maura V; Verano-Braga, Thiago

    2013-01-01

    nM) induces membrane depolarization, increases the spontaneous firing frequency and reduces spike amplitude of cockroach dorsal unpaired median (DUM) neurons. In addition, under voltage-clamp conditions, μ-TRTX-An1a (100 nM) only partially blocks voltage-dependent sodium current amplitudes in DUM...

  15. Dimensions of a class of high-dimensional homogeneous Moran sets and Moran classes

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A class of high-dimensional homogeneous Moran sets and Moran classes are introduced and some dimensional properties are studied. The Hausdorff dimension, modified lower box-counting dimension, lower and upper box-counting dimension, and packing dimension of high-dimensional homogeneous and partial homogeneous Cantor sets are determined. Moreover, a kind of fractal E is obtained, which is not regular but with the property Dimw(Ed)=dDimw(E), where w denotes any of the dimensions mentioned above.

  16. ON STUDENTS’PARTICIPATION IN ENGLISH CLASSES

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    The first possible difficulty an English teacher may encounter in his or her endeavor to make Eng-lish class more communicative may be students’ reluctance to participate.But there are reasonsbehind this seeming reluctance.Based on a recent survey,the paper analyzes students’ participa-tion psychology and both the subjective and objective factors,which may affect students’ activeparticipation in class.The writer of the paper believes that getting students started is the initialstep towards active learning and fruitful teaching.It is proposed that efforts made to get studentsinvolved should focus not only on forms of activities but also on their contents,on skill integra-tion and on establishing cooperative relationships between teacher and students and among stu-dents.

  17. Hopf cyclic cohomology and transverse characteristic classes

    CERN Document Server

    Moscovici, Henri

    2010-01-01

    By refining the cyclic cohomological apparatus for computing the Hopf cyclic cohomology of the Hopf algebras associated to infinite primitive Cartan-Lie pseudogroup, we explicitly identify, as a Hopf cyclic complex, the image of the canonical homomorphism from the Gelfand-Fuks complex to the Bott complex for equivariant cohomology. Distinct from the original realization due to A. Connes and the first named author of the cyclic cohomology of such Hopf algebras as differentiable cyclic cohomology, this construction provides a convenient front-end model for their Hopf cyclic cohomology. Relying on it, we produce characteristic homomorphisms from newly developed models for Hopf cyclic characteristic classes to the cyclic cohomology of the convolution algebras of \\'etale holonomy groupoids, which in particular work in the relative case with no compactness restriction. As an illustration, we apply the latter feature to transfer the universal Hopf cyclic Chern classes found by us in a previous paper, and produce in ...

  18. SMA Observations of Class 0 Protostars

    DEFF Research Database (Denmark)

    Chen, Xuepeng; Arce, Héctor G.; Zhang, Qizhou;

    2013-01-01

    We present high angular resolution 1.3 mm and 850 μm dust continuum data obtained with the Submillimeter Array toward 33 Class 0 protostars in nearby clouds (distance ... in the survey is 2.''5, while the median linear resolution is approximately 600 AU. Compact dust continuum emission is observed from all sources in the sample. Twenty-one sources in the sample show signatures of binarity/multiplicity, with separations ranging from 50 AU to 5000 AU. The numbers of singles......, binaries, triples, and quadruples in the sample are 12, 14, 5, and 2, respectively. The derived multiplicity frequency (MF) and companion star fraction (CSF) for Class 0 protostars are 0.64 ± 0.08 and 0.91 ± 0.05, respectively, with no correction for completeness. The derived MF and CSF in this survey...

  19. Global Elite as Transnational Capitalist Class

    Directory of Open Access Journals (Sweden)

    Lukáš Kantor

    2017-01-01

    Full Text Available As a contribution to the burgeoning field of multidisciplinary globalization studies, this article evaluates how IR grand theories can conceptualize the phenomenon of global elite. It compares and synthesizes (neoliberalism, constructivism, feminism and neo-Marxism. Liberal approaches use the analytical tool of transnational actors or transnational networks. In constructivist’s perspective, part of global elite falls into the category of epistemic community. Feminists offer the term Davos Men. Neo-Marxist conceptualization revolves around the notion of transnational capitalist class. The paper concludes that neo-Marxist IR theory best accounts for the global elite and therefore, the debates on the transnational capitalist class are thoroughly and critically reviewed.

  20. AUTOCLASS III - AUTOMATIC CLASS DISCOVERY FROM DATA

    Science.gov (United States)

    Cheeseman, P. C.

    1994-01-01

    The program AUTOCLASS III, Automatic Class Discovery from Data, uses Bayesian probability theory to provide a simple and extensible approach to problems such as classification and general mixture separation. Its theoretical basis is free from ad hoc quantities, and in particular free of any measures which alter the data to suit the needs of the program. As a result, the elementary classification model used lends itself easily to extensions. The standard approach to classification in much of artificial intelligence and statistical pattern recognition research involves partitioning of the data into separate subsets, known as classes. AUTOCLASS III uses the Bayesian approach in which classes are described by probability distributions over the attributes of the objects, specified by a model function and its parameters. The calculation of the probability of each object's membership in each class provides a more intuitive classification than absolute partitioning techniques. AUTOCLASS III is applicable to most data sets consisting of independent instances, each described by a fixed length vector of attribute values. An attribute value may be a number, one of a set of attribute specific symbols, or omitted. The user specifies a class probability distribution function by associating attribute sets with supplied likelihood function terms. AUTOCLASS then searches in the space of class numbers and parameters for the maximally probable combination. It returns the set of class probability function parameters, and the class membership probabilities for each data instance. AUTOCLASS III is written in Common Lisp, and is designed to be platform independent. This program has been successfully run on Symbolics and Explorer Lisp machines. It has been successfully used with the following implementations of Common LISP on the Sun: Franz Allegro CL, Lucid Common Lisp, and Austin Kyoto Common Lisp and similar UNIX platforms; under the Lucid Common Lisp implementations on VAX/VMS v5

  1. Bianchi Class B Spacetimes with Electromagnetic Fields

    CERN Document Server

    Yamamoto, Kei

    2011-01-01

    We carry out a thorough analysis on a class of cosmological spacetimes which admit three space-like Killing vectors of Bianchi class B and contain electromagnetic fields. Using dynamical system analysis, we show that a family of vacuum plane-wave solutions of the Einstein-Maxwell equations is the stable attractor for expanding universes. Phase dynamics are investigated in detail for particular symmetric models. We integrate the system exactly for some special cases to confirm the qualitative features. Some of the obtained solutions have not been presented previously to the best of our knowledge. Finally, based on those solutions, we discuss the relation between those homogeneous models and perturbations of open FLRW universes. We argue that the vacuum plane-wave modes correspond to a certain long-wavelength limit of electromagnetic perturbations.

  2. An Analysis on an ESL Class

    Institute of Scientific and Technical Information of China (English)

    杜岳青

    2015-01-01

    Input is the precondition of interaction and output while output promotes the input and the interaction of language,which could increase the effectiveness of input and enhance the chance of the absorption of interaction.By analyzing an ESL class,this paper gives readers a picture of how the second language(SL)learners get information,absorb and digest the information,produce language and form their language system in their SL learning.At last,it gives suggestions on how to ensure language learners have a better chance to get comprehensible input,assimilate language during interaction and output more accurate and comprehensible second language in an ESL class.

  3. Equilibria, Fixed Points, and Complexity Classes

    CERN Document Server

    Yannakakis, Mihalis

    2008-01-01

    Many models from a variety of areas involve the computation of an equilibrium or fixed point of some kind. Examples include Nash equilibria in games; market equilibria; computing optimal strategies and the values of competitive games (stochastic and other games); stable configurations of neural networks; analysing basic stochastic models for evolution like branching processes and for language like stochastic context-free grammars; and models that incorporate the basic primitives of probability and recursion like recursive Markov chains. It is not known whether these problems can be solved in polynomial time. There are certain common computational principles underlying different types of equilibria, which are captured by the complexity classes PLS, PPAD, and FIXP. Representative complete problems for these classes are respectively, pure Nash equilibria in games where they are guaranteed to exist, (mixed) Nash equilibria in 2-player normal form games, and (mixed) Nash equilibria in normal form games with 3 (or ...

  4. Spatial segmentation and the black middle class.

    Science.gov (United States)

    Sharkey, Patrick

    2014-01-01

    Ethnographic studies of the black middle class focus attention on the ways in which residential environments condition the experiences of different segments of the black class structure. This study places these arguments in a larger demographic context by providing a national analysis of neighborhood inequality and spatial inequality of different racial and ethnic groups in urban America. The findings show that there has been no change over time in the degree to which majority-black neighborhoods are surrounded by spatial disadvantage. Predominantly black neighborhoods, regardless of socioeconomic composition, continue to be spatially linked with areas of severe disadvantage. However, there has been substantial change in the degree to which middle- and upper-income African-American households have separated themselves from highly disadvantaged neighborhoods. These changes are driven primarily by the growing segment of middle- and upper-income African-Americans living in neighborhoods in which they are not the majority group, both in central cities and in suburbs.

  5. Small generators of the ideal class group

    Science.gov (United States)

    Belabas, Karim; Diaz, Francisco Diaz Y.; Friedman, Eduardo

    2008-06-01

    Assuming the Generalized Riemann Hypothesis, Bach has shown that the ideal class group ļof a number field K can be generated by the prime ideals of K having norm smaller than 12big(logabs{mathrm{Discriminant}(K)}big)^2 . This result is essential for the computation of the class group and units of K by Buchmann's algorithm, currently the fastest known. However, once mathcal{C}ell_K has been computed, one notices that this bound could have been replaced by a much smaller value, and so much work could have been saved. We introduce here a short algorithm which allows us to reduce Bach's bound substantially, usually by a factor 20 or so. The bound produced by the algorithm is asymptotically worse than Bach's, but favorable constants make it useful in practice.

  6. Perception of classroom climate in gym classes

    Directory of Open Access Journals (Sweden)

    Vlasta Zabukovec

    2001-09-01

    Full Text Available This presentation is a part of larger study among Slovene primary and secondary students and their sports' teachers, related to their attitude to gym classes. In this part the results of perception of classroom climate among students will be presented. In the research, 1152 students were participated; they were from fifth and seventh grade from primary school and first and third grade form secondary school. The questionnaire Classroom climate in sport classes was applied (actual and preferred form, which included seven dimensions: satisfaction, competitiveness, methods, students' activity, difficulty, adequateness and personal relationship. Results confirmed the changes in perception of classroom climate; they decreased form fifth grade of primary school to third grade of secondary school. The changes were more extensive in primary school, from primary to secondary school and became stable in secondary school. The differences in perception of classroom climate between boys and girls were confirmed, too.

  7. USING ENGLISH FILMS IN COLLEGE ENGLISH CLASSES

    Institute of Scientific and Technical Information of China (English)

    ZhuHanchang; ShiHongshi

    2004-01-01

    English films are valuable and rich resources for English learning and teaching in that they present colloquial English in more "realistic" contexts, an opportunity of being exposed to different native speaker voices,slang, reduced speeches, stress, accents, ana dialects, This article introauces the criteria of choosing appropriate films to promote active viewing and effective involvement of non-English majors to make the most of films as well as some practical skills of integrating English course book learning with English films in English classes. Besides, some effective means are provided for data building and video clip making in the hope of stimulating more teachers to use English movies effectively in College English classes.

  8. A Maximal Tractable Class of Soft Constraints

    CERN Document Server

    Cohen, D; Jeavons, P; Krokhin, A; 10.1613/jair.1400

    2011-01-01

    Many researchers in artificial intelligence are beginning to explore the use of soft constraints to express a set of (possibly conflicting) problem requirements. A soft constraint is a function defined on a collection of variables which associates some measure of desirability with each possible combination of values for those variables. However, the crucial question of the computational complexity of finding the optimal solution to a collection of soft constraints has so far received very little attention. In this paper we identify a class of soft binary constraints for which the problem of finding the optimal solution is tractable. In other words, we show that for any given set of such constraints, there exists a polynomial time algorithm to determine the assignment having the best overall combined measure of desirability. This tractable class includes many commonly-occurring soft constraints, such as 'as near as possible' or 'as soon as possible after', as well as crisp constraints such as 'greater than'. F...

  9. Community College Class Devoted to Astronomical Research

    Science.gov (United States)

    Genet, R. M.; Genet, C. L.

    2002-05-01

    A class at a small community college, Central Arizona College, was dedicated to astronomical research. Although hands-on research is usually reserved for professionals or graduate students, and occasionally individual undergraduate seniors, we decided to introduce community college students to science by devoting an entire class to research. Nine students were formed into three closely cooperating teams. The class as a whole decided that all three teams would observe Cepheid stars photometrically using a robotic telescope at the Fairborn Observatory. Speaker-phone conference calls were made to Kenneth E. Kissell for help on Cepheid selection, Michael A. Seeds for instructions on the use of the Phoenix-10 robotic telescope, and Douglas S. Hall for assitance in selecting appropriate comparison and check stars. The students obtained critical references on past observations from Konkoly Observatory via airmail. They spent several long night sessions at our apartment compiling the data, making phase calculations, and creating graphs. Finally, the students wrote up their results for publication in a forthcoming special issue of the international journal on stellar photometry, the IAPPP Communication. We concluded that conducting team research is an excellent way to introduce community college students to science, that a class devoted to cooperation as opposed to competition was refreshing, and that group student conference calls with working astronomers were inspiring. A semester, however, is a rather short time to initiate and complete research projects. The students were Sally Baldwin, Cory Bushnell, Bryan Dehart, Pamela Frantz, Carl Fugate, Mike Grill, Jessica Harger, Klay Lapa, and Diane Wiseman. We are pleased to acknowledge the assistance provided by the astronomers mentioned above, James Stuckey (Campus Dean), and our Union Institute and University doctoral committee members Florence Pittman Matusky, Donald S. Hayes, and Karen S. Grove.

  10. Broadband S-band class E HPA

    NARCIS (Netherlands)

    Wanum, van M.; Dijk, van R.; Hek, de A.P.; Vliet, van F.E.

    2009-01-01

    A broadband class E High Power Amplifier (HPA) is presented. This HPA is designed to operate at S-band (2.75 to 3.75 GHz). A power added efficiency of 50% is obtained for the two stage amplifier with an output power of 35.5 dBm on a chip area of 5.25 times 2.8 mm2.

  11. Broadband S-band Class E HPA

    NARCIS (Netherlands)

    Wanum, M. van; Dijk, R. van; Hek, A.P. de; Vliet, F.E. van

    2009-01-01

    A broadband class E High Power Amplifier (HPA) is presented. This HPA is designed to operate at S-band (2.75 to 3.75 GHz). A power added efficiency of 50% is obtained for the two stage amplifier with an output power of 35.5 dBm on a chip area of 5.25 × 2.8 mm2.

  12. Chaotification for a class of nonlinear systems

    Institute of Scientific and Technical Information of China (English)

    Liu Na; Guan Zhi-Hong

    2009-01-01

    More and more attention has been focused on effectively generating chaos via simple physical devices. The problem of creating chaotic attractors is considered for a class of nonlinear systems with backlash function in this paper. By utilizing the Silnikov heteroclinic and homoclinic theorems, some sufficient conditions are established to guarantee that the nonlinear system has horseshoe-type chaos. Examples and simulations are given to verify the effectiveness of the theoretical results.

  13. Discovering Classes of Strongly Equivalent Logic Programs

    OpenAIRE

    Chen, Y.; Lin, F.

    2011-01-01

    In this paper we apply computer-aided theorem discovery technique to discover theorems about strongly equivalent logic programs under the answer set semantics. Our discovered theorems capture new classes of strongly equivalent logic programs that can lead to new program simplification rules that preserve strong equivalence. Specifically, with the help of computers, we discovered exact conditions that capture the strong equivalence between a rule and the empty set, between two rules, between t...

  14. The Complexity of Identifying Large Equivalence Classes

    DEFF Research Database (Denmark)

    Skyum, Sven; Frandsen, Gudmund Skovbjerg; Miltersen, Peter Bro

    1999-01-01

    We prove that at least 3k−4/k(2k−3)(n/2) – O(k)equivalence tests and no more than 2/k (n/2) + O(n) equivalence tests are needed in the worst case to identify the equivalence classes with at least k members in set of n elements. The upper bound is an improvement by a factor 2 compared to known res...

  15. Polarity for a Class of Levy Processes

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Polar set of Markov processes is an important concept in probabilistic potential theory, but it is not easy to judge the polarity of the sets. In this paper, we give some results which can be easily used to examine the polarity of the sets when Xt belongs to a special class of Levy processes. We also give a result about polar functions of symmetric stable processes.

  16. A Survey of English Reading Outside Class

    Institute of Scientific and Technical Information of China (English)

    Peng; Yuan

    2015-01-01

    The aims of middle school English teaching areto cultivate students to acquire reading competence,which enable them to gain the information.Reading is the required method to collect information and material.This paper reports a survey on reading outside class among senior school students,by the way of questionnaires and interview,including the interests,focus,assignment of reading time,selection of reading materials,reading motives and other aspects..

  17. A Survey of English Reading Outside Class

    Institute of Scientific and Technical Information of China (English)

    Peng Yuan

    2015-01-01

    The aims of middle school English teaching are to cultivate students to acquire reading competence,which enable them to gain the information.Reading is the required method to collect information and material.This paper reports a survey on reading outside class among senior school students,by the way of questionnaires and interview,including the interests,focus,assignment of reading time,selection of reading materials,reading motives and other aspects..

  18. Improving Learners' Reading Skill in EFL Class

    Institute of Scientific and Technical Information of China (English)

    杨颖

    2008-01-01

    Topics around helping students to acquire the skill of reading have become increasingly popular in the discussion of foreign language teaching.In this paper,the author emphasizes the importance of improving learners'reading skill,presents the understanding of three factors concerning how to impmve learners' reading comprehension in EFL class and then introduces a 90-minute lesson plan to illustrate the statements.

  19. Celebrity chav : fame, femininity and social class.

    OpenAIRE

    2010-01-01

    There is nothing new about celebrity culture. It is an intrinsic feature of a world structured by mechanical reproduction. However, what has been visible over the last few years in Britain is a modulation of representations of celebrity figures in entertainment and news media through reality TV series, newspapers and gossip magazines. In this article, we argue that celebrity is an increasingly significant means by which reactionary class attitudes, allegiances and judgements are communicated....

  20. Another Class of Perfect Nonlinear Polynomial Functions

    Directory of Open Access Journals (Sweden)

    Menglong Su

    2013-01-01

    Full Text Available Perfect nonlinear (PN functions have been an interesting subject of study for a long time and have applications in coding theory, cryptography, combinatorial designs, and so on. In this paper, the planarity of the trinomials xpk+1+ux2+vx2pk over GF(p2k are presented. This class of PN functions are all EA-equivalent to x2.

  1. The latent class multitrait-multimethod model.

    Science.gov (United States)

    Oberski, Daniel L; Hagenaars, Jacques A P; Saris, Willem E

    2015-12-01

    A latent class multitrait-multimethod (MTMM) model is proposed to estimate random and systematic measurement error in categorical survey questions while making fewer assumptions than have been made so far in such evaluations, allowing for possible extreme response behavior and other nonmonotone effects. The method is a combination of the MTMM research design of Campbell and Fiske (1959), the basic response model for survey questions of Saris and Andrews (1991), and the latent class factor model of Vermunt and Magidson (2004, pp. 227-230). The latent class MTMM model thus combines an existing design, model, and method to allow for the estimation of the degree to and manner in which survey questions are affected by systematic measurement error. Starting from a general form of the response function for a survey question, we present the MTMM experimental approach to identification of the response function's parameters. A "trait-method biplot" is introduced as a means of interpreting the estimates of systematic measurement error, whereas the quality of the questions can be evaluated by item information curves and the item information function. An experiment from the European Social Survey is analyzed and the results are discussed, yielding valuable insights into the functioning of a set of example questions on the role of women in society in 2 countries.

  2. Parallel Array Classes and Lightweight Sharing Mechanisms

    Directory of Open Access Journals (Sweden)

    Steve W. Otto

    1993-01-01

    Full Text Available We discuss a set of parallel array classes, MetaMP, for distributed-memory architectures. The classes are implemented in C++ and interface to the PVM or Intel NX message-passing systems. An array class implements a partitioned array as a set of objects distributed across the nodes – a "collective" object. Object methods hide the low-level message-passing and implement meaningful array operations. These include transparent guard strips (or sharing regions that support finite-difference stencils, reductions and multibroadcasts for support of pivoting and row operations, and interpolation/contraction operations for support of multigrid algorithms. The concept of guard strips is generalized to an object implementation of lightweight sharing mechanisms for finite element method (FEM and particle-in-cell (PIC algorithms. The sharing is accomplished through the mechanism of weak memory coherence and can be efficiently implemented. The price of the efficient implementation is memory usage and the need to explicitly specify the coherence operations. An intriguing feature of this programming model is that it maps well to both distributed-memory and shared-memory architectures.

  3. Efficient Tracking of Large Classes of Experts

    CERN Document Server

    Gyorgy, András; Lugosi, Gábor

    2011-01-01

    In the framework for prediction of individual sequences, sequential prediction methods are to be constructed that perform nearly as well as the best expert from a given class. We consider prediction strategies that compete with the class of switching strategies that can segment a given sequence into several blocks, and follow the advice of a different "base" expert in each block. As usual, the performance of the algorithm is measured by the regret defined as the excess loss relative to the best switching strategy selected in hindsight for the particular sequence to be predicted. In this paper we construct prediction strategies of low computational cost for the case where the set of base experts is large. In particular we derive a family of efficient tracking algorithms that, for any prediction algorithm $\\A$ designed for the base class, can be implemented with time and space complexity $O(n^{\\gamma} \\log n)$ times larger than that of $\\A$, where $n$ is the time horizon and $\\gamma \\ge 0$ is a parameter of the...

  4. New Classes of Charged Spheroidal Models

    Directory of Open Access Journals (Sweden)

    S. Thirukkanesh

    2013-01-01

    Full Text Available New classes of exact solutions to the Einstein-Maxwell system is found in closed form by assuming that the hypersurface is spheroidal. This is achieved by choosing a particular form for the electric field intensity. A class of solution is found for all positive spheroidal parameter for a specific form of electric field intensity. In general, the condition of pressure isotropy reduces to a difference equation with variable, rational coefficients that can be solved. Consequently, an explicit solution in series form is found. By placing restrictions on the parameters, it is shown that the series terminates and there exist two classes of solutions in terms of elementary functions. These solutions contain the models found previously in the limit of vanishing charge. Solutions found are directly relating the spheroidal parameter and electric field intensity. Masses obtained are consistent with the previously reported experimental and theoretical studies describing strange stars. A physical analysis indicates that these models may be used to describe a charged sphere.

  5. Class Wars: Initial Steps Into The Fray

    Directory of Open Access Journals (Sweden)

    Lebor, Merv

    2013-01-01

    Full Text Available This article explores the issue of preparing trainee teachers for the challenges of how to face their students’ ‘disruptive behaviour’ which sometimes marks the beginning and sets the tone for the remainder of sessions. In this paper I explore my work mentoring two trainee teachers, looking at the options available to them on entering classrooms where students displayed disruptive behaviour. There is a context of Ofsted criteria, whereby disruptive behaviour is no longer acceptable and ‘failure’ is allocated as an observation grade where ‘disruptive behaviour’ occurs. This piece offers an exploration of classroom management strategies for preparing trainee teachers who face challenging situations in Further Education (FE environments and suggests strategies for dealing with the difficulties of disruptive classes. The reason why this is vitally important is because trainee teachers in Cert Ed classes wish to discuss this issue more than any other topic. It affects their self-esteem, confidence and class interaction in delivering the curriculum.

  6. The NRAO Observing for University Classes Program

    Science.gov (United States)

    Cannon, John M.; Van Moorsel, Gustaaf A.

    2017-01-01

    The NRAO "Observing for University Classes" program is a tremendous resource for instructors of courses in observational astronomy. As a service to the astronomical and educational communities, the NRAO offers small amounts of observing time on the Very Large Array (VLA) and the Very Long Baseline Array to such instructors. The data can be used by students and faculty to demonstrate radio astronomy theory with modern data products. Further, the results may lead to publication; this is a unique opportunity for faculty members to integrate research into the classroom. Previous experience with NRAO facilities is required for instructors; individuals without radio astronomy experience can take advantage of other NRAO educational opportunities (e.g., the Synthesis Imaging Workshop) prior to using the program. No previous experience with radio astronomy data is required for students; this is the primary target audience of the program. To demonstrate concept, this poster describes three different VLA observing programs that have been completed using the "Observing for University Classes" resource at Macalester College; undergraduate students have published the results of all three of these programs. Other recent "Observing for University Classes" programs are also described.

  7. X-Windows Socket Widget Class

    Science.gov (United States)

    Barry, Matthew R.

    2006-01-01

    The X-Windows Socket Widget Class ("Class" is used here in the object-oriented-programming sense of the word) was devised to simplify the task of implementing network connections for graphical-user-interface (GUI) computer programs. UNIX Transmission Control Protocol/Internet Protocol (TCP/IP) socket programming libraries require many method calls to configure, operate, and destroy sockets. Most X Windows GUI programs use widget sets or toolkits to facilitate management of complex objects. The widget standards facilitate construction of toolkits and application programs. The X-Windows Socket Widget Class encapsulates UNIX TCP/IP socket-management tasks within the framework of an X Windows widget. Using the widget framework, X Windows GUI programs can treat one or more network socket instances in the same manner as that of other graphical widgets, making it easier to program sockets. Wrapping ISP socket programming libraries inside a widget framework enables a programmer to treat a network interface as though it were a GUI.

  8. A escolarização das classes abastadas The schooling of the affluent classes

    Directory of Open Access Journals (Sweden)

    Antonio David Cattani

    2007-12-01

    Full Text Available Após indicar a inadequação do termo elite ou burguesia para designar os detentores de grandes fortunas, este artigo sustenta que as classes dominantes se constroem continuamente e se mobilizam de todas as formas para assegurar sua reprodução ampliada, sua existência cotidiana com vistas à preservação e à transmissão das posições dominantes para seus descendentes. A formação ideológica na família e o período de formação nas instituições escolares são parte importantes do processo de construção de classe. O artigo considera que os estudos sobre a escolarização das classes dedicam-se, de modo geral, à formação universal, com ênfase nos problemas que acometem a população menos privilegiada. Os estudos sobre a formação da classe dominante são recentes e apresentam resultados inusitados tais como a relação instrumental com a educação o que distinguiria o caso brasileiro das estratégias das classes abastadas dos países economicamente mais avançados. Entretanto, como as classes dominantes são heterogêneas elas podem se valer de outras estratégias de escolarização para garantir suas posições e a reprodução de classe.After pointing out the inadequacy of the terms elite or bourgeoisie to label those in possession of great wealth, this article maintains that the dominant classes are constantly constructing and mobilizing themselves in every way to assure their extended reproduction and their everyday coexistence with the aim of preserving and transmitting dominant positions to their descendents. Ideological development within the family and the school years are important elements in the process of class construction. Studies on schooling of class generally address universal education, stressing the problems that afflict the underprivileged population. The education of the dominant class is not often explored as a topic and the few studies available present original results, such as the instrumental

  9. Hierarchical Maximum Margin Learning for Multi-Class Classification

    CERN Document Server

    Yang, Jian-Bo

    2012-01-01

    Due to myriads of classes, designing accurate and efficient classifiers becomes very challenging for multi-class classification. Recent research has shown that class structure learning can greatly facilitate multi-class learning. In this paper, we propose a novel method to learn the class structure for multi-class classification problems. The class structure is assumed to be a binary hierarchical tree. To learn such a tree, we propose a maximum separating margin method to determine the child nodes of any internal node. The proposed method ensures that two classgroups represented by any two sibling nodes are most separable. In the experiments, we evaluate the accuracy and efficiency of the proposed method over other multi-class classification methods on real world large-scale problems. The results show that the proposed method outperforms benchmark methods in terms of accuracy for most datasets and performs comparably with other class structure learning methods in terms of efficiency for all datasets.

  10. Apo-ghrelin receptor (apo-GHSR1a Regulates Dopamine Signaling in the Brain

    Directory of Open Access Journals (Sweden)

    Andras eKern

    2014-08-01

    Full Text Available The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a is expressed mainly in the central nervous system (CNS. In this review we confine our discussion to the physiological role of GHSR1a in the brain. Paradoxically, despite broad expression of GHSR1a in the CNS, other than trace amounts in the hypothalamus, ghrelin is undetectable in the brain. In our efforts to elucidate the function of the ligand-free ghrelin receptor (apo-GHSR1a we identified subsets of neurons that co-express GHSR1a and dopamine receptors. In this review we focus on interactions between apo-GHSR1a and dopamine-2 receptor (DRD2 and formation of GHSR1a:DRD2 heteromers in hypothalamic neurons that regulate appetite, and discuss implications for the treatment of Prader-Willi syndrome. GHSR1a antagonists of distinct chemical structures, a quinazolinone and a triazole, respectively enhance and inhibit dopamine signaling through GHSR1a:DRD2 heteromers by an allosteric mechanism. This finding illustrates a potential strategy for designing the next generation of drugs for treating eating disorders as well as psychiatric disorders caused by abnormal dopamine signaling. Treatment with a GHSR1a antagonist that enhances dopamine/DRD2 activity in GHSR1a:DRD2 expressing hypothalamic neurons has the potential to inhibit the uncontrollable hyperphagia associated with Prader-Willi syndrome. DRD2 antagonists are prescribed for treating schizophrenia, but these block dopamine signaling in all DRD2 expressing neurons and are associated with adverse side effects, including enhanced appetite and excessive weight gain. A GHSR1a antagonist of structural class that allosterically blocks dopamine/DRD2 action in GHSR1a:DRD2 expressing neurons would have no effect on neurons expressing DRD2 alone; therefore, the side effects of DRD2 antagonists would potentially be reduced thereby enhancing patient compliance.

  11. Disability, disparate impact, and class actions.

    Science.gov (United States)

    Stein, Michael Ashley; Waterstone, Michael E

    2006-12-01

    Following Title VII's enactment, group-based employment discrimination actions flourished due to disparate impact theory and the class action device. Courts recognized that subordination that defined a group's social identity was also sufficient legally to bind members together, even when relief had to be issued individually. Woven through these cases was a notion of panethnicity that united inherently unrelated groups into a common identity, for example, Asian Americans. Stringent judicial interpretation subsequently eroded both legal frameworks and it has become increasingly difficult to assert collective employment actions, even against discriminatory practices affecting an entire group. This deconstruction has immensely disadvantaged persons with disabilities. Under the Americans with Disabilities Act (ADA), individual employee claims to accommodate specific impairments, such as whether to install ramps or replace computer screens, have all but eclipsed a coherent theory of disability-based disparate impact law. Moreover, the class action device has been virtually nonexistent in disability discrimination employment cases. The absence of collective action has been especially harmful because the realm of the workplace is precisely where group-based remedies are needed most. Specifically, a crucial but overlooked issue in disability integration is the harder-to-reach embedded norms that require job and policy modifications. The Article argues that pandisability theory serves as an analogue to earlier notions of panethnicity and provides an equally compelling heuristic for determining class identity. It shows that pandisability undergirds ADA public service and public accommodation class actions in which individualized remedy assessments have been accepted as part of group-based challenges to social exclusion. The Article also demonstrates that this broader vision of collective action is consistent with the history underlying the class action device. Taking

  12. MW-Class Electric Propulsion System Designs

    Science.gov (United States)

    LaPointe, Michael R.; Oleson, Steven; Pencil, Eric; Mercer, Carolyn; Distefano, Salvador

    2011-01-01

    Electric propulsion systems are well developed and have been in commercial use for several years. Ion and Hall thrusters have propelled robotic spacecraft to encounters with asteroids, the Moon, and minor planetary bodies within the solar system, while higher power systems are being considered to support even more demanding future space science and exploration missions. Such missions may include orbit raising and station-keeping for large platforms, robotic and human missions to near earth asteroids, cargo transport for sustained lunar or Mars exploration, and at very high-power, fast piloted missions to Mars and the outer planets. The Advanced In-Space Propulsion Project, High Efficiency Space Power Systems Project, and High Power Electric Propulsion Demonstration Project were established within the NASA Exploration Technology Development and Demonstration Program to develop and advance the fundamental technologies required for these long-range, future exploration missions. Under the auspices of the High Efficiency Space Power Systems Project, and supported by the Advanced In-Space Propulsion and High Power Electric Propulsion Projects, the COMPASS design team at the NASA Glenn Research Center performed multiple parametric design analyses to determine solar and nuclear electric power technology requirements for representative 300-kW class and pulsed and steady-state MW-class electric propulsion systems. This paper describes the results of the MW-class electric power and propulsion design analysis. Starting with the representative MW-class vehicle configurations, and using design reference missions bounded by launch dates, several power system technology improvements were introduced into the parametric COMPASS simulations to determine the potential system level benefits such technologies might provide. Those technologies providing quantitative system level benefits were then assessed for technical feasibility, cost, and time to develop. Key assumptions and primary

  13. Lattices of Schunck Classes of Finite Universal Algebras

    Institute of Scientific and Technical Information of China (English)

    Wenbin Guo; K.P. Shum

    2003-01-01

    We prove that the set of all Schunck classes of Mal'cev algebras satisfying the maximum condition for subalgebras is a distributive lattice and its sublattice consisting of all Schunck classes of finite algebras is algebraic. This generalizes many results in the literature on Schunck classes. We also obtain some equivalent conditions for a class of algebras to be a Schunck class and investigate the structure of the class (algebras A |τ(A) = {A}), where τ is a subsystem functor.2000 Mathematics Subject Classification: 08A05, 08B05

  14. Reliability and agreement in student ratings of the class environment.

    Science.gov (United States)

    Nelson, Peter M; Christ, Theodore J

    2016-09-01

    The current study estimated the reliability and agreement of student ratings of the classroom environment obtained using the Responsive Environmental Assessment for Classroom Teaching (REACT; Christ, Nelson, & Demers, 2012; Nelson, Demers, & Christ, 2014). Coefficient alpha, class-level reliability, and class agreement indices were evaluated as each index provides important information for different interpretations and uses of student rating scale data. Data for 84 classes across 29 teachers in a suburban middle school were sampled to derive reliability and agreement indices for the REACT subscales across 4 class sizes: 25, 20, 15, and 10. All participating teachers were White and a larger number of 6th-grade classes were included (42%) relative to 7th- (33%) or 8th- (23%) grade classes. Teachers were responsible for a variety of content areas, including language arts (26%), science (26%), math (20%), social studies (19%), communications (6%), and Spanish (3%). Coefficient alpha estimates were generally high across all subscales and class sizes (α = .70-.95); class-mean estimates were greatly impacted by the number of students sampled from each class, with class-level reliability values generally falling below .70 when class size was reduced from 25 to 20. Further, within-class student agreement varied widely across the REACT subscales (mean agreement = .41-.80). Although coefficient alpha and test-retest reliability are commonly reported in research with student rating scales, class-level reliability and agreement are not. The observed differences across coefficient alpha, class-level reliability, and agreement indices provide evidence for evaluating students' ratings of the class environment according to their intended use (e.g., differentiating between classes, class-level instructional decisions). (PsycINFO Database Record

  15. Screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients

    DEFF Research Database (Denmark)

    Thomsen, L.L.; Oestergaard, E.; Bjornsson, A.;

    2008-01-01

    The aim of this study was to investigate the involvement of the CACNA1A and ATP1A2 gene in a population-based sample of sporadic hemiplegic migraine (SHM). Patients with SHM (n = 105) were identified in a nationwide search in the Danish population. We sequenced all exons and promoter regions...... of the CACNA1A and ATP1A2 genes in 100 patients with SHM to search for possible SHM mutations. Novel DNA variants were discovered in eight SHM patients, four in exons of the CACNA1A gene and four in exons of the ATP1A2 gene. Six of the variants were considered non-pathogenic. The causal role of the two...... remaining DNA variants is unknown until functional studies have been made or independent genetic evidence is discovered. Only very few DNA variants were identified in 100 SHM patients, and regardless of whether the identified variants are causal the CACNA1A and ATP1A2 genes are not major genes in SHM...

  16. 5-HT(1A) receptors and memory.

    Science.gov (United States)

    Meneses, Alfredo; Perez-Garcia, Georgina

    2007-01-01

    The study of 5-hydroxytryptamine (5-HT) systems has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT(1)-5-HT(7)). Increasing evidence suggests that 5-HT pathways, reuptake site/transporter complex and 5-HT receptors represent a strategic distribution for learning and memory. A key question still remaining is whether 5-HT markers (e.g., receptors) are directly or indirectly contributing to the physiological and pharmacological basis of memory and its pathogenesis or, rather, if they represent protective or adaptable mechanisms (at least in initial stages). In the current paper, the major aim is to revise recent advances regarding mammalian 5-HT(1A) receptors in light of their physiological, pathophysiological and therapeutic implications in memory. An attempt is made to identify and discuss sources of discrepancies by employing an analytic approach to examine the nature and degree of difficulty of behavioral tasks used, as well as implicating other factors (for example, brain areas, training time or duration, and drug administration) which might offer new insights into the understanding and interpretation of these data. In this context, 8-OH-DPAT deserves special attention since for many years it has been the more selective 5-HT drug and, hence, more frequently used. As 5-HT(1A) receptors are key components of serotonergic signaling, investigation of their memory mechanisms and action sites and the conditions under which they might operate, could yield valuable insights. Moreover, selective drugs with agonists, neutral antagonists or inverse agonist properties for 5-HT(1A) (and 5-HT(7)) receptors may constitute a new therapeutic opportunity for learning and memory disorders.

  17. Earth and Sky, Unit 1A

    DEFF Research Database (Denmark)

    Gammelgaard Nielsen, Anders

    2011-01-01

    The assignment known as ‘Earth and sky’ is the final first year course at Unit 1a. The aim of the assignment is to strengthen the student’s abilities to manage a project process individu- ally. The process involves develop- ing the ability to make independent decisions.The point of departure...... for the ‘Earth and sky’ assignment is ex- perience students acquired during their group study tour to Austra- lia. Building in particular on the re- search conducted on the Sydney Opera House and the architectur- al principles of spatial creation that this building represents....

  18. Mutation classes of certain quivers with potentials as derived equivalence classes

    CERN Document Server

    Ladkani, Sefi

    2011-01-01

    We characterize the marked bordered unpunctured oriented surfaces with the property that all the Jacobian algebras of the quivers with potentials arising from their triangulations are derived equivalent. These are either surfaces of genus g with b boundary components and one marked point on each component, or the disc with 4 or 5 points on its boundary. We show that for each such marked surface, all the quivers in the mutation class have the same number of arrows, and the corresponding Jacobian algebras constitute a complete derived equivalence class of finite-dimensional algebras whose members are connected by sequences of Brenner-Butler tilts. In addition, we provide explicit quivers for each of these classes. We consider also 10 of the 11 exceptional finite mutation classes of quivers not arising from triangulations of marked surfaces excluding the one of the quiver X_7, and show that all the finite-dimensional Jacobian algebras in such class (for suitable choice of potentials) are derived equivalent only ...

  19. Lateral cephalometric diagnosis of asymmetry in Angle Class II subdivision compared to Class I and II

    Directory of Open Access Journals (Sweden)

    Aparecida Fernanda Meloti

    2014-08-01

    Full Text Available INTRODUCTION: Lateral cephalometric radiographs are traditionally required for orthodontic treatment, yet rarely used to assess asymmetries. OBJECTIVE: The objective of the present study was to use lateral cephalometric radiographs to identify existing skeletal and dentoalveolar morphological alterations in Class II subdivision and to compare them with the existing morphology in Class I and II relationship. MATERIAL AND METHODS: Ninety initial lateral cephalometric radiographs of male and female Brazilian children aged between 12 to 15 years old were randomly and proportionally divided into three groups: Group 1 (Class I, Group 2 (Class II and Group 3 (Class II subdivision. Analysis of lateral cephalometric radiographs included angular measurements, horizontal linear measurements and two indexes of asymmetry that were prepared for this study. RESULTS: In accordance with an Index of Dental Asymmetry (IDA, greater mandibular dental asymmetry was identified in Group 3. An Index of Mandibular Asymmetry (IMA revealed less skeletal and dental mandibular asymmetry in Group 2, greater skeletal mandibular asymmetry in Group 1, and greater mandibular dental asymmetry in Group 3. CONCLUSION: Both IDA and IMA revealed greater mandibular dental asymmetry for Group 3 in comparison to Groups 1 and 2. These results are in accordance with those found by other diagnostic methods, showing that lateral cephalometric radiography is an acceptable method to identify existing skeletal and dentoalveolar morphological alterations in malocclusions.

  20. Sensitivity Analysis of Gas Production from Class 2 and Class 3 Hydrate Deposits

    Energy Technology Data Exchange (ETDEWEB)

    Reagan, Matthew; Moridis, George; Zhang, Keni

    2008-05-01

    Gas hydrates are solid crystalline compounds in which gas molecules are lodged within the lattices of an ice-like crystalline solid. The vast quantities of hydrocarbon gases trapped in hydrate formations in the permafrost and in deep ocean sediments may constitute a new and promising energy source. Class 2 hydrate deposits are characterized by a Hydrate-Bearing Layer (HBL) that is underlain by a saturated zone of mobile water. Class 3 hydrate deposits are characterized by an isolated Hydrate-Bearing Layer (HBL) that is not in contact with any hydrate-free zone of mobile fluids. Both classes of deposits have been shown to be good candidates for exploitation in earlier studies of gas production via vertical well designs - in this study we extend the analysis to include systems with varying porosity, anisotropy, well spacing, and the presence of permeable boundaries. For Class 2 deposits, the results show that production rate and efficiency depend strongly on formation porosity, have a mild dependence on formation anisotropy, and that tighter well spacing produces gas at higher rates over shorter time periods. For Class 3 deposits, production rates and efficiency also depend significantly on formation porosity, are impacted negatively by anisotropy, and production rates may be larger, over longer times, for well configurations that use a greater well spacing. Finally, we performed preliminary calculations to assess a worst-case scenario for permeable system boundaries, and found that the efficiency of depressurization-based production strategies are compromised by migration of fluids from outside the system.