Sample records for cisplatin-based highly emetogenic

  1. Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy | Division of Cancer Prevention (United States)

    RATIONALE: Acupressure wristbands may prevent or reduce nausea and caused by chemotherapy. It is not yet known whether standard care is more effective with or without acupressure wristbands in controlling acute and delayed nausea. PURPOSE: This randomized phase III trial is studying how well acupressure wristbands work with or without standard care in controlling nausea in young patients receiving highly emetogenic chemotherapy. |

  2. Cisplatin-based chemotherapy: Add high-frequency audiometry in the regimen

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    R Arora


    Full Text Available Background : Cisplatin-induced ototoxicity shows high interindividual variability and is often accompanied by transient or permanent tinnitus. It is not possible to identify the susceptible individuals before commencement of the treatment. We conducted a prospective, randomized and observational study in a tertiary care centre and evaluated the effects of different doses of cisplatin on hearing. Materials and Methods : Fifty-seven patients scheduled for cisplatin-based chemotherapy were included in the study. All patients were divided into three groups depending on the dose of cisplatin infused in 3 weeks. Results : The subjective hearing loss was found in seven patients, while six patients had tinnitus during the chemotherapy. The hearing loss was sensorineural, dose dependent, symmetrical, bilateral and irreversible. Higher frequencies were first to be affected in cisplatin chemotherapy. Conclusion : As use of high-frequency audiometry is still limited in research work only, we need a strict protocol of adding high-frequency audiometry in the cisplatin-based chemotherapy regimen.

  3. Cardiovascular Events in Cancer Patients Treated with Highly or Moderately Emetogenic Chemotherapy: Results from a Population-Based Study

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    Thao T. Vo


    Full Text Available Studies on cardiovascular safety in cancer patients treated with highly or moderately emetogenic chemotherapy (HEC or MEC, who may have taken the antiemetic, aprepitant, have been limited to clinical trials and postmarketing spontaneous reports. Our study explored background rates of cardiovascular disease (CVD events among HEC- or MEC-treated cancer patients in a population-based setting to contextualize events seen in a new drug development program and to determine at a high level whether rates differed by aprepitant usage. Medical and pharmacy claims data from the 2005–2007 IMPACT National Benchmark Database were classified into emetogenic chemotherapy categories and CVD outcomes. Among 5827 HEC/MEC-treated patients, frequencies were highest for hypertension (16–21% and composites of venous (7–12% and arterial thromboembolic events (4–7%. Aprepitant users generally did not experience higher frequencies of events compared to nonusers. Our study serves as a useful benchmark of background CVD event rates in a population-based setting of cancer patients.

  4. Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy | Division of Cancer Prevention (United States)

    This randomized phase III trial studies antiemetic therapy with olanzapine to see how well they work compared to antiemetic therapy alone in preventing chemotherapy-induced nausea and vomiting in patients with cancer receiving highly emetogenic (causes vomiting) chemotherapy. Antiemetic drugs, such as palonosetron hydrochloride, ondansetron, and granisetron hydrochloride, may help lessen or prevent nausea and vomiting in patients treated with chemotherapy. |

  5. Pharmacokinetics, safety, and efficacy of APF530 (extended-release granisetron in patients receiving moderately or highly emetogenic chemotherapy: results of two Phase II trials

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    Gabrail N


    Full Text Available Nashat Gabrail,1 Ronald Yanagihara,2 Marek Spaczyński,3 William Cooper,4 Erin O'Boyle,5 Carrie Smith,1 Ralph Boccia6 1Gabrail Cancer Center, Canton, OH, USA; 2St Louise Regional Hospital, Gilroy, CA, USA; 3Department of Gynecology, Obstetrics and Gynecologic Oncology, University of Medical Sciences, Poznan, Poland; 4TFS International, Flemington, NJ, USA; 5FibroGen, Inc., San Francisco, CA, USA; 6Center for Cancer and Blood Disorders, Bethesda, MD, USA Background: Despite advances with new therapies, a significant proportion of patients (>30% suffer delayed-onset chemotherapy-induced nausea and vomiting (CINV despite use of antiemetics. APF530 is a sustained-release subcutaneous (SC formulation of granisetron for preventing CINV. APF530 pharmacokinetics, safety, and efficacy were studied in two open-label, single-dose Phase II trials (C2005-01 and C2007-01, respectively in patients receiving moderately emetogenic chemotherapy or highly emetogenic chemotherapy. Methods: In C2005-01, 45 patients received APF530 250, 500, or 750 mg SC (granisetron 5, 10, or 15 mg, respectively. In C2007-01, 35 patients were randomized to APF530 250 or 500 mg SC. Injections were given 30 to 60 minutes before single-day moderately emetogenic chemotherapy or highly emetogenic chemotherapy. Plasma granisetron was measured from predose to 168 hours after study drug administration. Safety and efficacy were also evaluated. Results: APF530 pharmacokinetics were dose proportional, with slow absorption and elimination of granisetron after a single SC dose. Median time to maximum plasma concentration and half-life were similar for APF530 250 and 500 mg in both trials, with no differences between the groups receiving moderately and highly emetogenic chemotherapy. Exposure to granisetron was maintained at a therapeutic level over the delayed-onset phase, at least 168 hours. Adverse events in both trials were as expected for granisetron; injection site reactions (eg, erythema

  6. Acute emesis: moderately emetogenic chemotherapy

    DEFF Research Database (Denmark)

    Herrstedt, Jørn; Rapoport, Bernardo; Warr, David


    This paper is a review of the recommendations for the prophylaxis of acute emesis induced by moderately emetogenic chemotherapy as concluded at the third Perugia Consensus Conference, which took place in June 2009. The review will focus on new studies appearing since the Second consensus conference...... receiving multiple cycles of moderately emetogenic chemotherapy will be reviewed. Consensus statements are given, including optimal dose and schedule of serotonin(3) receptor antagonists, dexamethasone, and neurokinin(1) receptor antagonists. The most significant recommendations (and changes since the 2004...... version of the guidelines) are as follows: the best prophylaxis in patients receiving moderately emetogenic chemotherapy (not including a combination of an anthracycline plus cyclophosphamide) is the combination of palonosetron and dexamethasone on the day of chemotherapy, followed by dexamethasone...

  7. High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area

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    Chien Chih-Yen


    Full Text Available Abstract Background This study was to evaluate the effect of excision repair cross-complementation group 1(ERCC1 expression on response to cisplatin-based induction chemotherapy (IC followed by concurrent chemoradiation (CCRT in locally advanced unresectable head and neck squamous cell carcinoma (HNSCC patients. Methods Fifty-seven patients with locally advanced unresectable HNSCC who received cisplatin-based IC followed by CCRT from January 1, 2006 through January 1, 2008. Eligibility criteria included presence of biopsy-proven HNSCC without a prior history of chemotherapy or radiotherapy. Immunohistochemistry was used to assess ERCC1 expression in pretreatment biopsy specimens from paraffin blocks. Clinical parameters, including smoking, alcohol consumption and betel nuts chewing, were obtained from the medical records. Results The 12-month progression-free survival (PFS and 2-year overall survival (OS rates of fifty-seven patients were 61.1% and 61.0%, respectively. Among these patients, thirty-one patients had low ERCC1 expression and forty-one patients responded to IC followed by CCRT. Univariate analyses showed that patients with low expression of ERCC1 had a significantly higher 12-month PFS rates (73.3% vs. 42.3%, p Conclusions Our study suggest that a high expression of ERCC1 predict a poor response and survival to cisplatin-based IC followed by CCRT in patients with locally advanced unresectable HNSCC in betel nut chewing area.

  8. Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity--state of the art. (United States)

    Grunberg, Steven M; Warr, David; Gralla, Richard J; Rapoport, Bernardo L; Hesketh, Paul J; Jordan, Karin; Espersen, Birgitte T


    Antiemetic drug development can follow the same logical path as antineoplastic drug development from appropriate preclinical models through Phase I, Phase II, and Phase III testing. However, due to the marked success of antiemetic therapy over the last 25 years, placebo antiemetic treatment against highly or moderately emetogenic chemotherapy is not acceptable. Promising antiemetic agents therefore rapidly reach Phase III testing, where they are substituted into or added to effective and accepted regimens. One challenge of antiemetic drug development is determining whether substitution is indeed acceptable or whether prior regimens must be maintained intact as a basis for further antiemetic drug development. An additional challenge is the classification of emetogenic level of new antineoplastic agents. Accurate reporting of emetogenicity of such antineoplastic agents in the absence of preventive antiemetic treatment may not be available. However, at the 2009 Multinational Association of Supportive Care in Cancer (MASCC)/European Society of Medical Oncology (ESMO) Consensus Conference, an expert panel used best available data to establish rankings of emetogenicity. Oral chemotherapeutic agents are ranked separately from intravenous agents, recognizing intrinsic differences in emetogenicity as well as differing schedules of administration. Since oral chemotherapeutic agents are often administered in extended regimens, the distinction between acute and delayed emesis is less clear, and cumulative emesis must be considered. As control of vomiting has improved, attention has shifted to control of nausea, a related but distinct and equally important problem. Additional efforts will be necessary to understand mechanisms of nausea and to identify optimal remedies.

  9. Efficacy and safety of casopitant mesylate, a neurokinin 1 (NK1)-receptor antagonist, in prevention of chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based highly emetogenic chemotherapy: a randomised, double-blind, placebo-controlled trial

    DEFF Research Database (Denmark)

    Grunberg, Steven M; Rolski, Janusz; Strausz, Janos


    was the proportion of patients achieving complete response (no vomiting, retching, or use of rescue medications) in the first 120 h after receiving HEC. Efficacy analysis was done on the modified intention-to-treat population (n=800), which included all patients who received placebo or study drug and HEC (n=265...... casopitant group achieved complete response in cycle 1 of HEC treatment than did those in the control group (175 [66%] patients in the control group, 228 [86%] in the single-dose oral casopitant mesylate group [p... (p=0.0004 vs control]). This improvement was sustained over multiple cycles of HEC. Adverse events occurred in 205 (77%) patients in the single-dose oral casopitant mesylate group and 203 (75%) patients in the 3-day intravenous and oral casopitant mesylate group compared with 194 (73%) of patients...

  10. Phase III Double-Blind, Placebo-Controlled Study of Gabapentin for the Prevention of Delayed Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Highly Emetogenic Chemotherapy, NCCTG N08C3 (Alliance) (United States)

    Barton, Debra L.; Thanarajasingam, Gita; Sloan, Jeff A.; Diekmann, Brent; Fuloria, Jyotsna; Kottschade, Lisa A.; Lyss, Alan P.; Jaslowski, Anthony J.; Mazurczak, Miroslaw A.; Blair, Scott C.; Terstriep, Shelby; Loprinzi, Charles L.


    BACKGROUND Despite targeted antiemetics, data support an unmet need related to the management of delayed nausea and vomiting (NV). Promising pilot data informed this phase III trial evaluating gabapentin for delayed NV from highly emetogenic chemotherapy (HEC). METHODS Participants were randomized to receive prophylactic treatment with 20 mg of dexamethasone and a 5HT3 receptor antagonist (RA) on the day of chemotherapy, followed by gabapentin 300 mg twice a day and dexamethasone (dex) or placebo and dex after HEC. Gabapentin/placebo was started the day of chemotherapy and continued through day 5 for the first chemotherapy cycle, whereas dex was titrated down on days 2–4. The primary end point was complete response (CR), defined as no emesis and no use of rescue medications on days 2–6, using an NV diary. The percentages of those in each group with a CR were compared by Fisher’s exact test. RESULTS Four hundred thirty patients were enrolled in this study. Forty-seven percent of patients in the gabapentin arm and 41% in the placebo arm had a CR (P = .23). Mean number of emesis episodes was <0.5 daily, and mean nausea severity was <2 (mild). In both arms, patient satisfaction with NV control was greater than 8 (with 10 being perfectly satisfied). There were no significant differences in unwanted side effects. CONCLUSIONS In this study, gabapentin did not significantly improve delayed NV. Patients were satisfied with the control of their nausea and vomiting irrespective of arm. The use of a 5HT3 RA and dexamethasone provided good control of nausea and vomiting for most patients. PMID:25043153

  11. The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential. (United States)

    Yamamoto, Kouichi; Nakai, Miho; Nohara, Kyoko; Yamatodani, Atsushi


    Cancer chemotherapy is frequently accompanied by severe emesis. The anti-cancer drugs are classified according to their clinical emetogenic potential. We have already found that kaolin ingestion behavior "pica" is analogous to emesis in rats. The aim of this study was to examine the effects of the clinical emetogenic potential of anti-cancer drugs on the induction of the pica in rats. Rats were housed in individual cages with free access to food and kaolin pellets and the daily food and kaolin intakes were measured for 3 days after the intraperitoneal administration of anti-cancer drugs (cisplatin, cyclophosphamide, actinomycin D, 5-fluorouracil and vincristine). The drugs with high potential for inducing emesis, such as cisplatin and cyclophosphamide, induced pica in all animals on the day of administration and the behavior lasted during the observation period. The drugs with moderate emetogenic potential, i.e. actinomycin D and 5-fluorouracil, also induced pica on the first and second day after the drug administration but the kaolin intake was less than that of the drugs with high potential. Vincristine, a drug with low emetogenic potential, slightly increased the kaolin intake in rats on the only first day of the administration. Cyclophosphamide, actinomycin D and vincristine induced anorexia and decreased their body weight during the observation period. These results suggested that the both amounts of kaolin intake and duration of behavior in the anti-cancer drug-induced pica are related to the clinical emetogenic potential of the drugs and the incidence of the anorexia is not related to their emetogenic potential.

  12. Efficacy of triplet regimen antiemetic therapy for chemotherapy-induced nausea and vomiting (CINV) in bone and soft tissue sarcoma patients receiving highly emetogenic chemotherapy, and an efficacy comparison of single-shot palonosetron and consecutive-day granisetron for CINV in a randomized, single-blinded crossover study. (United States)

    Kimura, Hiroaki; Yamamoto, Norio; Shirai, Toshiharu; Nishida, Hideji; Hayashi, Katsuhiro; Tanzawa, Yoshikazu; Takeuchi, Akihiko; Igarashi, Kentaro; Inatani, Hiroyuki; Shimozaki, Shingo; Kato, Takashi; Aoki, Yu; Higuchi, Takashi; Tsuchiya, Hiroyuki


    The first aim of this study was to evaluate combination antiemetic therapy consisting of 5-HT3 receptor antagonists, neurokinin-1 receptor antagonists (NK-1RAs), and dexamethasone for multiple high emetogenic risk (HER) anticancer agents in bone and soft tissue sarcoma. The second aim was to compare the effectiveness of single-shot palonosetron and consecutive-day granisetron in a randomized, single-blinded crossover study. A single randomization method was used to assign eligible patients to the palonosetron or granisetron arm. Patients in the palonosetron arm received a palonosetron regimen during the first and third chemotherapy courses and a granisetron regimen during the second and fourth courses. All patients received NK-1RA and dexamethasone. Patients receiving the palonosetron regimen were administered 0.75 mg palonosetron on day 1, and patients receiving the granisetron regimen were administered 3 mg granisetron twice daily on days 1 through 5. All 24 patients in this study received at least 4 chemotherapy courses. A total of 96 courses of antiemetic therapy were evaluated. Overall, the complete response CR rate (no emetic episodes and no rescue medication use) was 34%, while the total control rate (a CR plus no nausea) was 7%. No significant differences were observed between single-shot palonosetron and consecutive-day granisetron. Antiemetic therapy with a 3-drug combination was not sufficient to control chemotherapy-induced nausea and vomiting (CINV) during chemotherapy with multiple HER agents for bone and soft tissue sarcoma. This study also demonstrated that consecutive-day granisetron was not inferior to single-shot palonosetron for treating CINV.

  13. Delayed emesis: moderately emetogenic chemotherapy (single-day chemotherapy regimens only)

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    Roila, Fausto; Warr, David; Aapro, Matti


    An update of the recommendations for the prophylaxis of delayed emesis induced by moderately emetogenic chemotherapy discussed during the third Perugia Consensus Conference (June 2009) sponsored by MASCC-ESMO was presented. The review considered new studies published since the second consensus...

  14. Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer

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    Hsueh-Ju Lu


    Full Text Available Background. Triweekly cisplatin-based postoperative concurrent chemoradiotherapy (CCRT has high intolerance and toxicities in locally advanced head and neck cancer (LAHNC. We evaluated the effect of a modified weekly cisplatin-based chemotherapy in postoperative CCRT. Methods. A total of 117 patients with LAHNC were enrolled between December 2007 and December 2012. Survival, compliance/adverse events, and independent prognostic factors were analyzed. Results. Median follow-up time was 30.0 (3.1–73.0 months. Most patients completed the entire course of postoperative CCRT (radiotherapy ≥ 60 Gy, 94.9%; ≥6 times weekly chemotherapy, 75.2%. Only 17.1% patients required hospital admission. The most common adverse effect was grade 3/4 mucositis (28.2%. No patient died due to protocol-related adverse effects. Multivariate analysis revealed the following independent prognostic factors: oropharyngeal cancer, extracapsular spread, and total radiation dose. Two-year progression-free survival and overall survival rates were 70.9% and 79.5%, respectively. Conclusion. Modified weekly cisplatin-based chemotherapy is an acceptable regimen in postoperative CCRT for LAHNC.

  15. A clinical study of aprepitant for prevention of chemotherapy-induced vomiting induced by highly-moder-ately emetogenic chemotherapy%阿瑞匹坦预防中重度致吐性方案所致化疗相关性呕吐的临床研究

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    陈诚; 王晓华; 邓荣; 梅静峰; 许红霞


    目的:观察和评价阿瑞匹坦联合帕诺洛司琼、地塞米松预防和控制中重度致吐性化疗药物引起的化疗相关性呕吐的疗效。方法选择2014年1月至2014年12月在我院肿瘤内科和放疗科接受含多天中重度致吐性方案化疗的肿瘤患者,筛选应用帕诺洛司琼(0�25 mg iv,qod)+地塞米松(8 mg iv,qd)止吐后,呕吐达到2级或2级以上且需追加其他止吐药物解救治疗的患者共120例,于第2个周期同一方案化疗期间给予加用阿瑞匹坦(125 mg po,d1,80 mg po,d2~d3)止吐,并进行自身对照研究,比较患者应用阿瑞匹坦前后呕吐发生情况及耐受性。结果入组的所有患者在第1个周期均出现2级以上呕吐,第2个周期加用阿瑞匹坦后患者首次发生呕吐时间明显延迟,差异有统计学意义( P<0�01)。第2个周期与第1个周期的无呕吐率为59�2%(71/120)和0,而1、2、3级的呕吐发生率分别为29�2%(35/120)和0、9�1%(11/120)和60�8%(73/120)、2�5%(3/120)和39�2%(47/120),第2个周期的呕吐发生率低于未加用阿瑞匹坦的第1个周期( P<0�01)。主要不良反应包括食欲减退、乏力和便秘,均为1级。结论阿瑞匹坦与帕诺洛司琼及地塞米松联合用于治疗中重度致吐性方案化疗引起的严重消化道反应,可以显著改善化疗药物诱发的呕吐,且具有良好的耐受性。%Objective To evaluate the efficacy of aprepitant for prevention of highly⁃moderately emetogenic chemotherapy⁃in⁃duced vomiting. Methods Amomg the cancer patients underwent highly⁃moderately emetogenic chemotherapy from the January 2014 to December 2014 in the Department of Medical Oncology and Radiotherapy, 120 patients with vomiting of grade 2 or greater and requi⁃ring additional antiemetic drugs after treatment with palonosetron plus dexamethasone were chosen during the

  16. Comparison of Lorazepam, Diphenhydramine, Haloperidol Combined with Tropisetron and Dexamethasone Combined with Tropisetron Efficacy in Preventing Emesis Induced by Highly Emetogenic Chemotherapy%劳拉西泮、苯海拉明、氟哌啶醇联合托烷司琼对比地塞米松联合托烷司琼预防高致吐风险化疗呕吐的疗效

    Institute of Scientific and Technical Information of China (English)

    郭秋云; 于世英


    目的 探讨劳拉西泮(Ativan)、苯海拉明(Benadryl)和氟哌啶醇(Haldol)的方案(以下简称ABH)联合托烷司琼和地塞米松联合托烷司琼用于高致吐风险化疗[参见2011版多国癌症支持治疗学会(MASCC)止吐指南]后的急性、延迟性呕吐的疗效.方法 104例应用高致吐风险药物单天化疗的患者随机分为ABH组和地塞米松组,两组均在化疗前半小时静脉滴注托烷司琼5 mg,ABH组于化疗头4天予以劳拉西泮0.34 mg、苯海拉明25 mg、氟哌啶醇1.5 mg口服,每天3次;地基米松组于化疗当天予以地塞米松20 mg口服,化疗后3天予以地塞米松8 mg口服,每天2次.使用MASCC止吐问卷及生活功能指数(呕吐)问卷,了解患者急性及延迟性呕心呕吐控制率及生活质量.结果 ABH组和地塞米松组各入组52名患者.两组恶心、呕吐的控制均良好,急性恶心的控制率ABH组和地塞米松组分别为62%和52%,延迟性恶心情况分别为23%和17%,急性呕吐分别为88%和87%;延迟性呕吐分别为77%和65%,ABH的疗效优于地塞米松,但两者差异无统计学意义,可能与样本量小相关.值得一提的是,在延迟性恶心程度控制方面ABH组优于地塞米松组(2.63vs.3.69),两组差异有统计学意义(P<0.05).两组患者的生活质量均受到中度影响,差异无统计学意义,且均未发生严重不良反应.结论 劳拉西泮、苯海拉明、氟哌啶醇(ABH)联合5HT-3受体拮抗剂预防高致吐风险化疗后的恶心呕吐有一定疗效,可用于化疗相关恶心呕吐的防治.%Objective To comparè the efficacy of lorazepam,diphenhydramine and haloperidol(abbreviation as ABH)combined with Tropisetron therapies in preventing emesis induced by highly emetogenic chemotherapy refer to 2011 edition of MASCC antiemetic guidelines.Methods One hundred and four patients treated with highly emetogenic single day chemotherapy were randomized into ABH and dexamethasone group.Both groups

  17. 米氮平预防大剂量顺铂化疗的恶心和呕吐的临床研究%A clinical study about Mirtazapine to prevent nausea and emesis caused by high-dose cisplatin-based chemotherapy

    Institute of Scientific and Technical Information of China (English)

    郑艳群; 李志勇; 张艳清; 祝毓琳; 朱步东


    的恶心、呕吐和食欲减退;而迟发性呕吐改善相对更明显。%Objective To observe the effects and safety of Mirtazapine in prevention of nausea and emesis caused by high-dose cisplatin-based chemotherapy. Methods This was a self-controlled crossover clinical trial. Sixty-three patients, treated by high-dose cisplatin(60 mg/m2 or 75 mg/m2) plus gemcitabine, were randomly assigned to either control (A) cycle or Mirtazapine (B) cycle with first course, with crossover to the opposite treatment with the second course. The identical chemotherapy regimen was used on cycle A and cycle B. The d1-d5 served as first day through fifth day of chemotherapy cycle. The significant protection from nausea, emesis and anorexia was denoted as control rates, the complete protection rate denoted by CR rates. The control rates of nausea, emesis and anorexia on d1-d5 were observed. Patients received ondansetron with dexamethasone on cycle A to prevent nausea, emesis and anorexia. The mirtazapine in combination with ondansetron and dexamethasone was used on cycle B. Drug methods was used as following:Ondansetron 8 mg (intravenous, iv), once daily on days 1 and 2 of chemotherapy, cisplatin 60 mg/m2 or 75 mg/m2, iv, used in two-day schedules, mirtazapine 15 mg orally once daily on days 1 through 5 of chemotherapy, dexamethasone 5 mg iv, once per day on days 1 and 2, and gemcitabine 1000 mg/m2 or 1250 mg/m2, iv, once daily on days 1 and days 8. Results The control rate of nausea, acute emesis, delayed emesis and anorexia on cycle B or A was 71.4%(45/63) or 65.1%(41 /63)(P0.05), 74.6%(47/63) or 60.3%(38/63)(P<0.01), 49.2%(31/63) or 22.2%(19/63)(P<0.01), and 47.6%(30/63) or 23.8%(15/63)(P<0.05) of patients, respectively. More protection from delayed emesis was observed than from acute emesis (27.0% vs. 11.1%, P<0.01). No serious adverse events were observed on cycle B or A. Conclusion Mirtazapine is effective in treatment of nausea, emesis and anorexia caused by high dose

  18. Prometheus' spirit: quality survival in advanced hepatocellular carcinoma after gemcitabine and cisplatin-based chemotherapy. (United States)

    Doval, D C; Pande, S B; Sharma, J B; Pavithran, K; Jena, A; Vaid, A K


    In advanced virus-induced hepatocellular carcinoma (HCC) associated with cirrhosis, the average survival is four months. We report a 56-year-old man with a large-volume advanced HCC, in whom gemcitabine and cisplatin-based chemotherapy resulted in near-complete regression, and quality survival of 24 months.

  19. Cisplatin-based chemotherapy changes the incidence of bilateral testicular cancer

    NARCIS (Netherlands)

    vanBasten, JPA; Hoekstra, HJ; vanDriel, MF; Sleijfer, DT; Droste, JHJ; Schraffordt Koops, H.


    Background: The introduction of cisplatin-based chemotherapy has remarkably increased the survival of testicular cancer patients. With this success, the concern for a contraIateral testicular tumor has increased. The aim of this study was to investigate whether the risk for contralateral testicular

  20. Thrombosis of abdominal aorta during cisplatin-based chemotherapy of testicular seminoma - a case report

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    Gehrckens Ralf


    Full Text Available Abstract Background Vascular complications occurring during cisplatin-based chemotherapy of germ cell tumours are inadequately recognized to date. Case Presentation A 49 year old man with advanced seminoma underwent two courses of chemotherapy according to the PEB regimen. Upon restaging, two thrombotic deposits were noted in the descending part of the thoracic aorta and in the infrarenal abdominal aorta, respectively. Although thrombotic plaques caused aortic occlusion of about 30%, no clinical signs of malperfusion of limbs were registered. The patient was placed on anticoagulant therapy. Six months after completion of chemotherapy, thrombotic deposits had completely resolved. In the absence of other predisposing factors, it must be assumed that cisplatin-based chemotherapy represented a strong stimulus for arterial thrombosis in the aorta. Conclusions This is the first case of endo-aortic thrombosis during chemotherapy for testicular germ cell cancer. Providers of chemotherapy must be aware of arterial thrombosis even in young patients with testicular cancer.

  1. Primary Pure Squamous Cell Carcinoma of the Breast Might Be Sensitive to Cisplatin-Based Chemotherapy

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    Swei H. Tsung


    Full Text Available Pure squamous cell carcinoma of the breast (PSCCB is a rare condition. Surgery is usually the initial treatment. In some cases, complete excision of the tumor may be enough, while in other cases a mastectomy is required. In the literature, studies reported that PSCCB is an extremely aggressive disease associated with frequent locoregional and distant relapses and resultant death. Better therapy is therefore needed to improve patients’ outcome. A literature review revealed that several patients with locoregional and distant metastasis were successfully treated using cisplatin-based regimens. I encountered a case of a patient with PSCCB who received neoadjuvant therapy using cytoxan, epirubicin, and fluorouracil without any response. Therefore, she underwent a mastectomy with lymph node dissection. Local recurrence occurred 3 weeks after surgery. She was started on taxotere and cisplatin. Four months after therapy, the recurrent tumors completely regressed. At this point, there is only circumstantial evidence that cisplatin-based regimens could be a promising option for the treatment of PSCCB. Clinical trials including large series of PSCCB are needed to increase our knowledge.

  2. sFas levels increase in response to cisplatin-based chemotherapy in lung cancer patients. (United States)

    Ulukaya, Engin; Acilan, Ceyda; Yilmaz, Meryem; Yilmaztepe-Oral, Arzu; Ari, Ferda; Zik, Berrin; Ursavas, Ahmet; Tokullugil, Asuman H


    The Fas/Fas Ligand (FasL) system and survivin have counteracting roles in cell survival. Therefore, we explored the role of circulating soluble Fas (sFas) and the tissue levels of Fas and survivin with regard to response to chemotherapy in lung cancer patients. Serum samples from 52 lung cancer patients and 54 control subjects (19 benign lung disease and 35 healthy control subjects) were collected prior to and 24 and 48 h after chemotherapy. sFas was statistically significantly higher in the cancer group than that in the control groups (p  0,05). In conclusion, increased sFas may be an indicator of poor outcome in lung cancer patients. However, cisplatin-based chemotherapy may not be effective via neither the Fas/FasL system nor survivin pathway. Indeed, larger sample size is required for further evaluation.

  3. Risk factors associated with ineligibility of adjuvant cisplatin-based chemotherapy after nephroureterectomy

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    Shao IH


    Full Text Available I-Hung Shao,1,2,* Yu-Hsiang Lin,1,* Chen-Pang Hou,1 Horng-Heng Juang,3,4 Chien-Lun Chen,1 Phei-Lang Chang,1,4 Ke-Hung Tsui, 1,41Department of Urology, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 2Department of Urology, Lotung Poh-Ai Hospital, 3Department of Anatomy, Chang Gung University, 4Bioinformation Center, Chang Gung Memory Hospital, Kwei-Shan, Tao-Yuan, Taiwan, Republic of China*These authors contributed equally to this workPurpose: Radical nephroureterectomy (RNU is a standard treatment for upper urinary tract urothelial carcinoma. However, RNU can result in decreased renal function and cannot be treated with adjuvant chemotherapy. We performed a risk group stratification analysis to determine the preoperative factors that are predictive of diminished renal function after RNU.Materials and methods: We retrospectively evaluated the medical records of all patients who underwent nephroureterectomy for upper urinary tract urothelial carcinoma at the Chang Gung Memorial Hospital from 2001 to 2008. We analyzed the association between perioperative glomerular filtration rate and preoperative parameters including cancer characteristics, serum creatinine level, and kidney size measured on computed tomographic images.Results: A total of 242 patients fulfilled the inclusion criteria. The average decrease in renal function 1 month after RNU was 19.7%. Using 60 mL/min/1.73 m2 as the eligibility cutoff for cisplatin-based chemotherapy, 42.1% of the population was eligible prior to nephroureterectomy, whereas following surgery only 15.2% remained eligible. Using a cutoff of 45 mL/min/1.73 m2, 59.9% of the cohort was eligible for fractionated cisplatin dosing preoperatively, whereas only 32.6% remained above the cutoff postoperatively. The most significant predictors of poor postoperative renal function were body mass index >25 kg/m2, age >65 years, contralateral kidney length less than 10 cm, and absence of ipsilateral hydronephrosis

  4. ERCC1 mRNA levels can predict the response to cisplatin-based concurrent chemoradiotherapy of locally advanced cervical squamous cell carcinoma

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    Bai Zhou-lan


    Full Text Available Abstract Background The purpose of this study was to investigate whether the excision repair cross-complementation group 1 (ERCC1 mRNA expression could predict treatment response of patients with locally advanced cervical squamous cell carcinoma (LACSCC who underwent cisplatin-based concurrent chemoradiotherapy (CCCRT. Methods A total of sixty LACSCC patients, treated with radical CCCRT from a single institution were evaluated. ERCC1 mRNA expression was determined by quantitative real-time RT-PCR in pre-treatment tumor tissues. The association of ERCC1 status with clinicopathological characteristics (age, histological grade, tumor size, parametrial invasion, lymph node metastasis and FIGO stage and treatment response were analyzed. Results No significant association between ERCC1 mRNA expression and clinicopathological characteristics were observed. Patients with low ERCC1 mRNA level had a significantly higher rate of complete response (86.21% than patients with high level of ERCC1 expression (19.36%; p P  Conclusions This is the first analysis of the association between ERCC1 mRNA levels and treatment response in patients with LACSCC. Low ERCC1 mRNA level appears to be a highly specific predictor of response to CCCRT in LACSCC.

  5. Phase III trial of casopitant, a novel neurokinin-1 receptor antagonist, for the prevention of nausea and vomiting in patients receiving moderately emetogenic chemotherapy

    DEFF Research Database (Denmark)

    Herrstedt, Jørn; Apornwirat, Wichit; Shaharyar, Ahmed;


    PURPOSE: The purpose of this phase III trial was to evaluate the efficacy and safety of regimens containing casopitant, a novel neurokinin-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting during the first cycle in patients receiving moderately emetogenic chemo...... proportion of patients with nausea or significant nausea in those receiving casopitant. Adverse events were balanced among study arms. CONCLUSION: All casopitant regimens studied were more effective than the control regimen. Casopitant was generally well tolerated.......PURPOSE: The purpose of this phase III trial was to evaluate the efficacy and safety of regimens containing casopitant, a novel neurokinin-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting during the first cycle in patients receiving moderately emetogenic...... chemotherapy (MEC). PATIENTS AND METHODS: Predominantly female patients (98%) diagnosed with breast cancer (96%) who were chemotherapy-naïve and scheduled to receive an anthracycline and cyclophosphamide (AC) -based regimen were enrolled onto this multinational, randomized, double-blind, parallel...

  6. Comparative effectiveness and safety between oxaliplatin-based and cisplatin-based therapy in advanced gastric cancer: A meta-analysis of randomized controlled trials (United States)

    Zhu, Yanjie; Huang, Jiale; Liu, Yanna; Zhao, Liying; Li, Zhijia; Liu, Hao; Wang, Qi-long; Qi, Xiaolong


    Background & Aims Platinum-based drugs are the most significant chemotherapy for advanced gastric cancer. The study aims to compare the efficacy and safety of oxaliplatin-based therapy versus cisplatin-based therapy in patients with advanced gastric cancer. Materials and Methods An adequate literature search in EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, American Society of Clinical Oncology (ASCO) and European Society of Medical Oncology (ESMO) was conducted. Phase II or III randomized controlled trials (RCTs) that compared effectiveness and safety between oxaliplatin-based and cisplatin-based therapy in patients with advanced gastric cancer were eligible. The primary endpoint was overall response rate (ORR), progression free survival (PFS) and overall survival (OS). The second endpoint was the adverse events. Results Five phase II or III RCTs involving a total of 2,046 patients were identified. The results showed that there were no significant difference in ORR (OR = 1.17, 95% CI = 0.98–1.40, p = 0.08, I2 = 0%), PFS (HR = 0.92, 95% CI = 0.84–1.01, p = 0.09, I2 = 0%) and OS (HR = 0.91, 95% CI = 0.82–1.01, p = 0.07, I2 = 0%) between oxaliplatin-based therapy and cisplatin-based therapy. In addition, oxaliplatin-based therapy had lower risk of neutropenia, anemia, nausea, alopecia, thromboembolism, stomatitis and creatinine increased at all grades, and neutropenia, anemia, leukopenia and alopecia at 3–4 grades than cisplatin-based therapy. However, oxaliplatin-based therapy was associated with increased risk of neurosensory toxicity and thrombocytopenia. Conclusions Our meta-analysis showed that there were no significant difference in ORR, PFS and OS between oxaliplatin-based therapy and cisplatin-based therapy. The oxaliplatin-based therapy could generally decrease the risk of adverse effects except neurosensory toxicity and thrombocytopenia. PMID:27166187

  7. Single dose palonosetron and dexamethasone in preventing nausea and vomiting induced by high emetogenic ABVD regimen in Hodgkin Lymphoma patients. (United States)

    Rigacci, Luigi; Landi, Carla; Caruso, Jean Pierre; Puccini, Benedetta; Alterini, Renato; Carrai, Valentina; Perrone, Tania; Bosi, Alberto


    To evaluate the efficacy of a new agent, palonosetron, in Hodgkin Lymphoma patients treated with ABVD regimen. Complete response during the overall phase of the first ABVD cycle, was the primary endpoint. Secondary end points were: emesis-free patients and use of rescue medication during the acute and overall phases. From January 2008 to February 2009 36 patients were enrolled. The primary endpoint (CR 0-120 h) was achieved by 55.6% patients. In conclusion our study demonstrated that a single dose of palonosetron plus a single dose of dexamethasone was effective in preventing CINV in patients treated with ABVD regimen.

  8. Predictive factors for response and prognostic factors for long-term survival in consecutive, single institution patients with locally advanced and/or metastatic transitional cell carcinoma following cisplatin-based chemotherapy

    DEFF Research Database (Denmark)

    Jessen, Christian; Agerbaek, Mads; Von Der Maase, Hans


    PURPOSE: The study was undertaken to identify pre-treatment clinical and histopathological factors of importance for response and survival after cisplatin-based combination chemotherapy, in patients with locally advanced or metastatic transitional cell carcinoma of the urothelium. PATIENTS...

  9. Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy

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    Keck Bastian


    Full Text Available Abstract Background Since the definition of different histologic subtypes of urothelial carcinomas by the World Health Organization (WHO 2004 classification, description of molecular features and clinical behavior of these variants has gained more attention. Methods We reviewed 205 tumor samples of patients with locally advanced bladder cancer mainly treated within the randomized AUO-AB05/95 trial with radical cystectomy and adjuvant cisplatin-based chemotherapy for histologic subtypes. 178 UC, 18 plasmacytoid (PUC and 9 micropapillary (MPC carcinomas of the bladder were identified. Kaplan Meier analysis and backward multivariate Cox’s proportional hazards regression analysis were performed to compare overall survival between the three histologic subtypes. Results Patients suffering from PUC have the worst clinical outcome regarding overall survival compared to conventional UC and MPC of the bladder that in turn seem have to best clinical outcome (27.4 months, 62.6 months, and 64.2 months, respectively; p=0.013 by Kaplan Meier analysis. Backward multivariate Cox´s proportional hazards regression analysis (adjusted to relevant clinicopathological parameters showed a hazard ratio of 3.2 (p=0.045 for PUC in contrast to patients suffering from MPC. Conclusions Histopathological diagnosis of rare variants of urothelial carcinoma can identify patients with poor prognosis.

  10. Prognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy. (United States)

    Apolo, Andrea B; Ostrovnaya, Irina; Halabi, Susan; Iasonos, Alexia; Philips, George K; Rosenberg, Jonathan E; Riches, Jamie; Small, Eric J; Milowsky, Matthew I; Bajorin, Dean F


    A prognostic model that predicts overall survival (OS) for metastatic urothelial cancer (MetUC) patients treated with cisplatin-based chemotherapy was developed, validated, and compared with a commonly used Memorial Sloan-Kettering Cancer Center (MSKCC) risk-score model. Data from 7 protocols that enrolled 308 patients with MetUC were pooled. An external multi-institutional dataset was used to validate the model. The primary measurement of predictive discrimination was Harrell's c-index, computed with 95% confidence interval (CI). The final model included four pretreatment variables to predict OS: visceral metastases, albumin, performance status, and hemoglobin. The Harrell's c-index was 0.67 for the four-variable model and 0.64 for the MSKCC risk-score model, with a prediction improvement for OS (the U statistic and its standard deviation were used to calculate the two-sided P = .002). In the validation cohort, the c-indices for the four-variable and the MSKCC risk-score models were 0.63 (95% CI = 0.56 to 0.69) and 0.58 (95% CI = 0.52 to 0.65), respectively, with superiority of the four-variable model compared with the MSKCC risk-score model for OS (the U statistic and its standard deviation were used to calculate the two-sided P = .02).

  11. Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection

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    Lili Shen


    Full Text Available This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1 rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNaPshot method in 944 gastric cancer patients who received gastrectomy. The association of rs10505477 G > A polymorphism with the progression and prognosis in gastric cancer patients was statistically analyzed using the SPSS version 18.0 for Windows. The results reveal that rs10505477 polymorphism has a negatively effect on the overall survival of gastric cancer patients in cisplatin-based chemotherapy subgroup (HR = 1.764, 95% CI = 1.069–2.911, p = 0.023. Our preliminary study indicates for the first time that POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. Further studies are warranted to investigate the mechanism and to verify our results in different populations.

  12. Re-irradiation with cetuximab or cisplatin-based chemotherapy for recurrent squamous cell carcinoma of the head and neck

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    Dornoff, Nicolas; Weiss, Christian; Roedel, Franz [J. W. Goethe University, Department of Radiotherapy and Oncology, Frankfurt a. M. (Germany); Wagenblast, Jens [J. W. Goethe University, Department of Otorhinolaryngology, Frankfurt a. M. (Germany); Ghanaati, Shahram [J. W. Goethe University, Department of Maxillofacial Surgery, Frankfurt a. M. (Germany); Atefeh, Nateghian; Roedel, Claus; Balermpas, Panagiotis [J. W. Goethe University, Department of Radiotherapy and Oncology, Frankfurt a. M. (Germany); German Cancer Research Center (DKFZ), Heidelberg (Germany); German Cancer Consortium (DKTK) partner site: Frankfurt, Frankfurt a. M. (Germany)


    Locoregional recurrence remains the main pattern of failure after primary combined modality treatment of squamous cell carcinoma of the head and neck (SCCHN). We compared the efficacy and toxicity of either cisplatin or cetuximab in combination with re-irradiation (ReRT) for recurrent unresectable SCCHN. Various clinicopathological factors were investigated to establish a prognostic score. Between 2007 and 2014, 66 patients with recurrent SCCHN originating in a previously irradiated area received cetuximab (n = 33) or cisplatin-based chemotherapy (n = 33) concomitant with ReRT. Toxicity was evaluated weekly and at every follow-up visit. Physical examination, endoscopy, CT or MRI scans were used to evaluate response and disease control. With a mean follow-up of 18.3 months, the 1-year overall survival (OS) rates for Re-RT with cetuximab and cisplatin-based chemotherapy were 44.4 and 45.5 % (p = 0.352), respectively. At 1 year, local control rates (LCR) were 46.4 and 54.2 % (p = 0.625), freedom from metastases (FFM) rates 73.6 and 81 % (p = 0.842), respectively. Haematological toxicity ≥ grade 3 occurred more often in the cisplatin group (p < 0.001), pain ≥ grade 3 was increased in the cetuximab group (p = 0.034). A physiological haemoglobin level and a longer interval between primary RT and ReRT, proved to be significant prognostic factors for OS (multivariate: p = 0.003, p = 0.002, respectively). Site of the recurrence and gross target volume (GTV) did not show a significant impact on OS in multivariate analysis (p = 0.160, p = 0.167, respectively). A prognostic-score (1-4 points) based on these four variables identified significantly different subgroups: 1-year OS for 0/1/2/3/4 prognostic points: 10, 38, 76, 80 and 100 %, respectively (p < 0.001). Both cetuximab- and cisplatin-based ReRT of SCCHN recurrences are feasible and effective treatment options with comparable results in terms of tumour control and survival. Acute adverse events may differ slightly

  13. During twenty years of Cisplatin-based therapy the face of nonseminomatous testicular germ cell tumors is still changing: an evaluation of presentation, management, predictive factors and survival

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    Julia Heinzelbecker


    Full Text Available Purpose: To assess the changing presentation and treatment of nonseminomatous testicular germ cell tumors (NSGCT and to investigate predictive factors for the status of metastasis at diagnosis and on relapse and death. Materials and Methods: Retrospective record review of 147 patients that underwent inguinal orchiectomy from 1987-2007. Follow-up data was available for 102 patients (median follow-up: 80 months (0-243; 96 patients alive. Results: Mean patients age increased (p = 0.015 and more patients were diagnosed in clinical stage I (CSI (p = 0.040. The fraction of yolk sac (YS elements inclined (p = 0.030 and pT2 tumors increased (p I showed a declined CSS compared to CSI patients (p = 0.055. The presence of YS elements was associated to an improved RFS (p = 0.038. Conclusions: In our single institution study the face of NSGCT markedly changed over 20 years even after the introduction of Cisplatin-based chemotherapy. These changes were accompanied by an improvement in RFS and CSS. When dealing with NSGCT patients such observations now and in the future should be taken into account.

  14. Prognostic Value of Neutrophil-Related Factors in Locally Advanced Cervical Squamous Cell Carcinoma Patients Treated with Cisplatin-Based Concurrent Chemoradiotherapy. (United States)

    Wang, Yan-Yang; Bai, Zhou-Lan; He, Jian-Li; Yang, Yan; Zhao, Ren; Hai, Ping; Zhe, Hong


    The aim of this study was to explore the relationship between neutrophil-related factors, including neutrophil-lymphocyte ratio (NLR) and the responses of neutrophil to granulocyte colony-stimulating factors (RNG), and the prognosis of patients with locally advanced cervical squamous cell carcinoma (LACSCC) undergoing cisplatin-based concurrent chemoradiotherapy (CCCRT). A total of sixty LACSCC patients were enrolled in this study. We analyzed the association of NLR or RNG with clinicopathologic characteristics of these patients. The prognostic factors were evaluated by univariate and multivariate survival analysis. The optimal cut-off value of the NLR was determined to be 2.0 for the overall survival (OS). A higher level of the NLR was associated with younger age (P = 0.017) and higher baseline platelet count (P = 0.040). NLR was identified to be the only independent prognostic factor for OS by multivariate analysis (P = 0.037). The median RNG was 3.01, with a range of 1.19-16.84. RNG level was significantly associated with lymph node metastasis of these patients (P = 0.023). And higher RNG was identified as being a closely independent poor prognostic factor for OS (P = 0.055). This study showed that NLR and RNG may be used as potential biomarkers for survival prediction in patients with LACSCC receiving CCCRT.

  15. Palonosetron for the prevention of nausea and vomiting in children with acute lymphoblastic leukemia treated with high dose methotrexate

    DEFF Research Database (Denmark)

    Nadaraja, Sambavy; Mamoudou, Aissata Diop; Thomassen, Harald;


    High dose methotrexate (HD-MTX), used in the treatment of children with acute lymphoblastic leukemia (ALL), is moderately emetogenic. First generation 5-HT(3) receptor antagonists are effective prophylactic agents but require multiple administrations. Palonosetron has a half life of 36-42 hours a...... of palonosetron (5 µg/kg) for the prevention of chemotherapy-induced nausea and vomiting in children 18 years of age with ALL treated with HD-MTX, 5 g/m(2)....

  16. Reversal of multidrug resistance in human lung cancer cells by delivery of 3-octadecylcarbamoylacrylic acid–cisplatin-based liposomes (United States)

    Song, Juan; Ren, Weifang; Xu, Tingting; Zhang, Yi; Guo, Hongyu; Zhu, Shanshan; Yang, Li


    Liposome-based drug delivery system would be an innovative and promising candidate to circumvent multidrug resistance (MDR) of cisplatin (CDDP). However, the reversal efficacy of liposomal CDDP was severely impaired by weak cellular uptake and insufficient intracellular drug release. In this study, 3-octadecylcarbamoylacrylic acid–CDDP nanocomplex (OMI–CDDP–N)-based liposomes (OCP-L) with high cellular uptake and sufficient intracellular drug release were designed to circumvent MDR of lung cancer. OMI–CDDP–N was synthesized through a pH-sensitive monocarboxylato and an O→Pt coordinate bond, which is more efficient than CDDP. Also, OCP-L incorporated with OMI–CDDP–N could induce effective cellular uptake, enhanced nuclear distribution, and optimal cellular uptake kinetics. In particular, OCP-L presented superior effects on enhancing cell apoptosis and in vitro cytotoxicity in CDDP-resistant human lung cancer (A549/CDDP) cells. The mechanisms of MDR reversal in A549/CDDP cells by OCP-L could attribute to organic cation transporter 2 restoration, ATPase copper-transporting beta polypeptide suppression, hypoxia-inducible factor 1 α-subunit depletion, and phosphatidylinositol 3-kinase/Akt pathway inhibition. These results demonstrated that OCP-L may provide an effective delivery of CDDP to resistant cells to circumvent MDR and enhance the therapeutic index of the chemotherapy. PMID:28255230

  17. The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity. (United States)

    Davis, T Gregg; Peterson, John J; Kou, Jen-Pyng; Capper-Spudich, Elizabeth A; Ball, Doug; Nials, Anthony T; Wiseman, Joanne; Solanke, Yemisi E; Lucas, Fiona S; Williamson, Richard A; Ferrari, Livia; Wren, Paul; Knowles, Richard G; Barnette, Mary S; Podolin, Patricia L


    Clinical utility of phosphodiesterase 4 (PDE4) inhibitors as anti-inflammatory agents has, to date, been limited by adverse effects including nausea and emesis, making accurate assessment of emetic versus anti-inflammatory potencies critical to the development of inhibitors with improved therapeutic indices. In the present study we determined the in vitro and in vivo anti-inflammatory potencies of the first-generation PDE4 inhibitor, rolipram, the second-generation inhibitors, roflumilast and cilomilast, and a novel third generation inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1). The rank-order potency against lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha production by human peripheral blood mononuclear cells was roflumilast (IC(50) = 5 nM) > EPPA-1 (38) > rolipram (269) > cilomilast (389), and against LPS-induced pulmonary neutrophilia in the rat was EPPA-1 (D(50) = 0.042 mg/kg) > roflumilast (0.24) > rolipram (3.34) > cilomilast (4.54). Pica, the consumption of non-nutritive substances in response to gastrointestinal stress, was used as a surrogate measure for emesis, giving a rank-order potency of rolipram (D(50) = 0.495 mg/kg) > roflumilast (1.6) > cilomilast (6.4) > EPPA-1 (24.3). The low and high emetogenic activities of EPPA-1 and rolipram, respectively, detected in the pica model were confirmed in a second surrogate model of emesis, reversal of alpha(2)-adrenoceptor-mediated anesthesia in the mouse. The rank order of therapeutic indices derived in the rat [(pica D(50))/(neutrophilia D(50))] was EPPA-1 (578) > roflumilast (6.4) > cilomilast (1.4) > rolipram (0.15), consistent with the rank order derived in the ferret [(emesis D(50))/(neutrophilia D(50))]. These data validate rat pica feeding as a surrogate for PDE4 inhibitor-induced emesis in higher species, and identify EPPA-1 as a novel PDE4 inhibitor with an improved therapeutic index.

  18. Prognostic Value of Plasma Epstein-Barr Virus DNA for Local and Regionally Advanced Nasopharyngeal Carcinoma Treated With Cisplatin-Based Concurrent Chemoradiotherapy in Intensity-Modulated Radiotherapy Era. (United States)

    Chen, Wen-Hui; Tang, Lin-Quan; Guo, Shan-Shan; Chen, Qiu-Yan; Zhang, Lu; Liu, Li-Ting; Qian, Chao-Nan; Guo, Xiang; Xie, Dan; Zeng, Mu-Sheng; Mai, Hai-Qiang


    This study aimed to evaluate the prognostic value of plasma Epstein-Barr Virus DNA (EBV DNA) for local and regionally advanced nasopharyngeal carcinoma (NPC) patients treated with concurrent chemoradiotherapy in intensity-modulated radiotherapy (IMRT) era.In this observational study, 404 nonmetastatic local and regionally advanced NPC patients treated with IMRT and cisplatin-based concurrent chemotherapy were recruited. Blood samples were collected before treatment for examination of plasma EBV DNA levels. We evaluated the association of pretreatment plasma EBV DNA levels with progression-free survival rate (PFS), distant metastasis-free survival rate (DMFS), and overall survival rate (OS).Compared to patients with an EBV DNA level EBV DNA ≥ 4000  copies/mL had a lower rate of 3-year PFS (76%, 95% CI [68-84]) versus (93%, 95% CI [90-96], P EBV DNA levels (HR = 3.324, 95% CI, 1.80-6.138, P EBV DNA level was the only significant factor to predict DMFS (HR = 6.292, 95% CI, 2.647-14.956, P EBV DNA levels (HR = 3.753, 95% CI, 1.701-8.284, P EBV DNA levels still predicted a worse PFS, DMFS, and OS for the patients stage III or stage IVa-b, compared with those with low EBV DNA levels.Elevated plasma EBV DNA was still effective prognostic biomarker for local and regionally advanced NPC patients treated with IMRT and cisplatin-based concurrent chemotherapy. Future ramdomized clinical trials are needed to further evaluate whether plasma EBV DNA levels could be applied to guide concurrent chemotherapy regimen for local and regionally advanced NPC patients.

  19. In Silico Oncology: Quantification of the In Vivo Antitumor Efficacy of Cisplatin-Based Doublet Therapy in Non-Small Cell Lung Cancer (NSCLC) through a Multiscale Mechanistic Model (United States)

    Kolokotroni, Eleni; Dionysiou, Dimitra; Veith, Christian; Kim, Yoo-Jin; Franz, Astrid; Grgic, Aleksandar; Bohle, Rainer M.; Stamatakos, Georgios


    The 5-year survival of non-small cell lung cancer patients can be as low as 1% in advanced stages. For patients with resectable disease, the successful choice of preoperative chemotherapy is critical to eliminate micrometastasis and improve operability. In silico experimentations can suggest the optimal treatment protocol for each patient based on their own multiscale data. A determinant for reliable predictions is the a priori estimation of the drugs’ cytotoxic efficacy on cancer cells for a given treatment. In the present work a mechanistic model of cancer response to treatment is applied for the estimation of a plausible value range of the cell killing efficacy of various cisplatin-based doublet regimens. Among others, the model incorporates the cancer related mechanism of uncontrolled proliferation, population heterogeneity, hypoxia and treatment resistance. The methodology is based on the provision of tumor volumetric data at two time points, before and after or during treatment. It takes into account the effect of tumor microenvironment and cell repopulation on treatment outcome. A thorough sensitivity analysis based on one-factor-at-a-time and latin hypercube sampling/partial rank correlation coefficient approaches has established the volume growth rate and the growth fraction at diagnosis as key features for more accurate estimates. The methodology is applied on the retrospective data of thirteen patients with non-small cell lung cancer who received cisplatin in combination with gemcitabine, vinorelbine or docetaxel in the neoadjuvant context. The selection of model input values has been guided by a comprehensive literature survey on cancer-specific proliferation kinetics. The latin hypercube sampling has been recruited to compensate for patient-specific uncertainties. Concluding, the present work provides a quantitative framework for the estimation of the in-vivo cell-killing ability of various chemotherapies. Correlation studies of such estimates with

  20. Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy.

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    Wendi Zhou

    Full Text Available PURPOSE: The development of resistance against anticancer drugs has been a persistent clinical problem for the treatment of locally advanced malignancies in the head and neck mucosal derived squamous cell carcinoma (HNSCC. Recent evidence indicates that the DNA translesion synthesis (TLS polymerase η (Pol η; hRad30a gene reduces the effectiveness of gemcitabine/cisplatin. The goal of this study is to examine the relationship between the expression level of Pol η and the observed resistance against these chemotherapeutic agents in HNSCC, which is currently unknown. METHODS: Sixty-four mucosal derived squamous cell carcinomas of head and neck (HNSCC from 1989 and 2007 at the City of Hope National Medical Center (Duarte, CA were retrospectively analyzed. Pretreatment samples were immunostained with anti-Pol η antibody and the correlation between the expression level of Pol η and clinical outcomes were evaluated. Forty-nine cases treated with platinum (n=40 or gemcitabine (n=9 based chemotherapy were further examined for Pol η expression level for comparison with patient response to chemotherapy. RESULTS: The expression of Pol η was elevated in 67% of the head and neck tumor samples. Pol η expression level was significantly higher in grade 1 to grade 2 tumors (well to moderately differentiated. The overall benefit rate (complete response+ partial response in patients treated with platinum and gemcitabine based chemotherapy was 79.5%, where low Pol η level was significantly associated with high complete response rate (p=0.03, although not associated with overall survival. Furthermore, no significant correlation was observed between Pol η expression level with gender, age, tobacco/alcohol history, tumor stage and metastatic status. CONCLUSIONS: Our data suggest that Pol η expression may be a useful prediction marker for the effectiveness of platinum or gemcitabine based therapy for HNSCC.

  1. Hepatitis B reactivation during cisplatin-based adjuvant chemotherapy in HBsAg-positive patients with gastric carcinoma%乙型肝炎表面抗原阳性者胃癌术后以顺铂为基础的辅助化疗中乙型肝炎的再激活

    Institute of Scientific and Technical Information of China (English)

    于俊岩; 魏子白


    Objective To retrospectively investigate the incidence,outcome and risk factors of HBV reactivation in HBsAg-positive a patients with gastric carcinoma during cisplatin-based adjuvant chemotherapy.Methods We retrospectively reviewed the records of 2,538 patients with gastric carcinoma who received adjuvant chemotherapy from January 2005 to December 2010.Among these patients,146 HBsAg-positive patients were analyzed for the HBV reactivation in this study.The HBV serology and biochemical tests of the 146 patients were performed.The data were analyzed by chisquare test.Results Among 146 HBsAg-positive patients with gastric carcinoma,43 patients (29.5%) developed hepatitis,of which 29 (19.9%) were related to HBV reactivation.Univariate analysis showed that age ≥51 years (P=0.029) and abnormal liver uhrasonography findings such as fatty liver or early cirrhotic changes (P=0.031) were associated with HBV reactivation.However,gender,HBeAg positive status and the use of corticosteroids were not related with HBV reactivation.Conclusions HBV reactivation occurs in a significant proportion of HBsAg-positive patients with gastric carcinoma during adjuvant cisplatin-based chemotherapy.Once hepatitis developed,most patients could not finish the chemotherapy as planned despite lamivudine treatment.Therefore,HBsAg-positive gastric carcinoma patients should initiate prophylactic antiviral treatment before chemotherapy.%目的 了解HBsAg阳性者胃癌术后以顺铂为基础的辅助化疗中乙型肝炎的复发、转归及危险因素.方法 回顾性分析了2005年1月到2010年12月接受辅助化疗的2538例胃癌术后患者,观察HBsAg阳性患者乙型肝炎的再激活情况.所有入组患者进行HBV血清学和生物化学检测及接受以顺铂为基础的辅助化疗方案.数据进行X2检验.结果 146例HBsAg阳性胃癌术后患者中,43例(29.5%)进展为乙型肝炎,29例(19.9%)由于HBV复制激活而乙型肝炎复发.单因

  2. Clinical study for the efficacy of points acupressure combined with moxibustion in preventing gastrointestinal reactions caused by cisplatin-based chemotherapy%穴位按压联合艾灸减轻顺铂类化疗药物胃肠道反应的临床研究

    Institute of Scientific and Technical Information of China (English)

    凡国华; 林征; 陈勇; 罗红


    目的:观察穴位按压联合艾灸对减轻顺铂类化疗药物胃肠道反应的疗效。方法将100例行顺铂类药物化疗的恶性肿瘤患者随机分为实验组和对照组各50例。所有患者化疗期间均给予常规抑酸、止吐治疗,实验组同时加用中脘、内关、足三里、合谷穴位按压及艾灸治疗,每日两次,化疗前1d开始,至化疗后3d结束。比较两组患者化疗后胃肠道反应的发生率及症状分级有无差异。结果呕吐情况:实验组患者急性呕吐及延迟性呕吐的发生率均明显低于对照组(P<0.05),但在呕吐程度构成比方面,用药后1~3 d两组之间未见明显差异(P>0.05),而4~6 d实验组呕吐程度明显轻于对照组(P<0.05);恶心情况:实验组化疗期间恶心的发生率明显低于对照组(P<0.05),恶心程度也明显轻于对照组(P<0.05);食欲情况:实验组化疗期间食欲不振的发生率明显低于对照组(P<0.05),反应程度也明显轻于对照组(P<0.05)。结论穴位按压联合艾灸对顺铂类化疗药物引起的胃肠道反应有明显的防治作用,可明显减少化疗后恶心、呕吐及食欲不振等不良反应的发生,临床应用安全有效。%Objective To observe and assess the efficacy of points acupressure combined with moxibustion in pre-venting gastrointestinal reactions caused by cisplatin-based chemotherapy .Method 100 cancer patients with cisplatin-based chemotherapy was selected and randomly divided into experimental group and control group ,50 cases in each group .During chemotherapy period ,conventional acid suppression and anti-nausea treatment were used in both groups ,and the points acupressure combined with moxibustion were used in the experimental group twice a day , from 1 day before chemotherapy to 3 days after treatment .The incidences of gastrointestinal reaction and severity of symptom in two groups was

  3. High-dose metoclopramide + lorazepam versus low-dose metoclopramide + lorazepam + dehydrobenzperidol in the treatment of cisplatin-induced nausea and vomiting

    DEFF Research Database (Denmark)

    Herrstedt, Jørn; Hannibal, J; Hallas, Jesper;


    In a randomized double-blind, cross-over trial of 34 patients receiving cisplatin-based chemotherapy (20-100 mg/m2), the antiemetic effect of high-dose metoclopramide (HDM) (10 mg/kg iv. loading dose + 7 hours continuous infusion) + lorazepam (L) (2.5 mg x 4 po) was compared with low.......01). Sedation was seen in all but 1 patient, and was graded as severe in 6 patients receiving the HDM and in 2 patients receiving the LDM regimen. No extrapyramidal adverse reactions were seen. We conclude that high-dose metoclopramide + lorazepam is a safe antiemetic regimen and significantly superior to low...

  4. Extended high-frequency audiometry (9,000-20,000 Hz). Usefulness in audiological diagnosis. (United States)

    Rodríguez Valiente, Antonio; Roldán Fidalgo, Amaya; Villarreal, Ithzel M; García Berrocal, José R


    Early detection and appropriate treatment of hearing loss are essential to minimise the consequences of hearing loss. In addition to conventional audiometry (125-8,000 Hz), extended high-frequency audiometry (9,000-20,000 Hz) is available. This type of audiometry may be useful in early diagnosis of hearing loss in certain conditions, such as the ototoxic effect of cisplatin-based treatment, noise exposure or oral misunderstanding, especially in noisy environments. Eleven examples are shown in which extended high-frequency audiometry has been useful in early detection of hearing loss, despite the subject having a normal conventional audiometry. The goal of the present paper was to highlight the importance of the extended high-frequency audiometry examination for it to become a standard tool in routine audiological examinations.

  5. 经皮神经电刺激与穴位按压联合艾灸对减轻肺癌患者含顺铂方案化疗后胃肠道反应的对比研究%Comparison of therapeutic efficacy between transcutaneous electrical nerve stimulation and points acupressure combined with moxibustion in preventing gastrointestinal reactions caused by cisplatin-based chemotherapy of patients with lung cancer

    Institute of Scientific and Technical Information of China (English)

    凡国华; 徐兴祥; 陈勇; 闵凌峰; 林征


    Objective To compare the therapeutic efficacy between transcutaneous electrical nerve stimulation( TENS) and points acupressure combined with moxibustion in preventing gastrointestinal reactions caused by cisplatin-based chemotherapy of patients with lung cancer. Methods One hundred patients with lung cancer were randomly allocated to an TENS group of 50 cases and a TCM ( Traditional Chinese Medicine) group of 50 cases. During chemotherapy period, conventional anti-nausea treatments were used in both groups, and the TENS therapy were used in the TENS group while the points acupressure combined with moxibustion were used in the TCM group, twice a day, from the 1th day before chemotherapy to the 3rd day after it. Observe and compare incidences of gastrointestinal reaction and severity of symptoms in two groups from the first day to the sixth day of chemotherapy. Results The incidence and severity of nausea and vomiting have no significant difference between TENS group and TCM group(P>0.05). The incidence of anepithymia were significantly lower in TENS group than which in TCM group (P0.05);TENS组患者食欲不振的发生率低于中医组,差异有统计学意义(P<0.05),同时,TENS组食欲不振的症状程度也轻于中医组,差异有统计学意义( P<0.05)。结论 TENS与中医穴位按压联合艾灸治疗均可减轻肺癌患者含顺铂方案化疗所致的胃肠道反应,在降低患者恶心、呕吐的发生率及症状程度方面两组无明显差异,但在改善食欲不振发生率和症状程度方面,TENS治疗有一定优势。

  6. Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-Based Treatments

    Directory of Open Access Journals (Sweden)

    Loredana G. Marcu


    Full Text Available Advanced head and neck cancers are difficult to manage despite the large treatment arsenal currently available. The multidisciplinary effort to increase disease-free survival and diminish normal tissue toxicity was rewarded with better locoregional control and sometimes fewer side effects. Nevertheless, locoregional recurrence is still one of the main reasons for treatment failure. Today, the standard of care in head and neck cancer management is represented by altered fractionation radiotherapy combined with platinum-based chemotherapy. Targeted therapies as well as chronotherapy were trialled with more or less success. The aim of the current work is to review the available techniques, which could contribute towards a higher therapeutic ratio in the treatment of advanced head and neck cancer patients.

  7. The effects of Ginkgo biloba on nephrotoxicity induced by cisplatin-based chemotherapy protocols in rats


    Okuyan, Betül; Izzettin, Fikret Vehbi; Bingöl-Ozakpinar, Özlem; Turan, Pınar; Ozdemir, Zarife Nigar; Sancar, Mesut; Cirakli, Zeynep; Clark, Philip Martin; Ercan, Feriha


    The study was aimed at investigating the possible renoprotective effects of Ginkgo biloba on nephrotoxicity induced by cisplatin w/wo other antineoplastic agents (etoposide and gemcitabine) in rats. The animals were randomly divided into eight groups each consisting of six rats. Serum blood urea nitrogen (BUN) and creatinine values at baseline and after drug administration, kidney malondialdehyde (MDA), glutathione (GSH) levels, and myeloperoxidase activity (MPO) were measured, an...

  8. Is High Dose Therapy Superior to Conventional Dose Therapy as Initial Treatment for Relapsed Germ Cell Tumors? The TIGER Trial

    Directory of Open Access Journals (Sweden)

    Darren R. Feldman, Robert Huddart, Emma Hall, Jörg Beyer, Thomas Powles


    Full Text Available Metastatic germ cell tumours (GCTs are usually cured with cisplatin based chemotherapy and standard treatment algorithms are established. However when this treatment fails and the disease relapses, standard treatment is much more uncertain. Both conventional dose therapy (CDT and high dose therapy (HDT are widely used, due to the lack of conclusive data supporting one specific approach. A recent retrospective analysis focusing on this population suggested a significant benefit for HDT. Retrospective analyses are prone to bias, and therefore while this data is provocative it is by no mean conclusive. For this reason the international community is supporting a prospective randomised trial in this area comparing CDT(TIP with sequential HDT (TICE. The planned open labelled randomised phase III study (TIGER is due to open in 2011 and will recruit 390 patients to detect a 13% difference in 2 year progression free survival (primary endpoint. It is hoped that this large study will conclusively resolve the uncertainty which currently exists.

  9. Integrated safety analysis of rolapitant with coadministered drugs from phase II/III trials

    DEFF Research Database (Denmark)

    Barbour, S; Smit, V.H.T.B.M.; Wang, X


    Background: Rolapitant, a long-acting neurokinin (NK) 1 receptor antagonist (RA), has demonstrated efficacy in prevention of chemotherapy-induced nausea and vomiting in patients administered moderately or highly emetogenic chemotherapy. Unlike other NK 1 RAs, rolapitant does not inhibit or induce...

  10. A randomized trial of two doses of granisetron in the treatment of chemotherapy-induced emesis. Dutch results within a multinational study. (United States)

    Bots, M W; Dijkstra, H J; Blijham, G H; van der Wall, E; Fehmers, M C; Keizer, H J; Nortier, J W; Siegenbeek van Heukelom, L; Slee, P H; Veenhof, C H


    Granisetron is a new serotonin-receptor antagonist with considerable activity in preclinical models and early clinical studies against drug-induced nausea and vomiting. In a randomized, double-blind trial, two dose levels of granisetron were compared with regard to their efficacy and safety if given to patients receiving emetogenic chemotherapy with or without cisplatin. The present paper reports the Dutch experience with 125 patients included in this international trial. The two dose levels (40 and 160 micrograms/kg given once i.v. prior to chemotherapy) were equally effective in preventing acute emesis and nausea (within the first 24 h); in the group receiving cisplatin doses of 50 mg/m2 or more, 39% of patients had a complete response (no vomiting and mild nausea at most), with a complete response rate of 82% in the patients receiving moderately emetogenic chemotherapy. Sixty-three percent of patients receiving highly emetogenic chemotherapy with a complete response within 24 h lost this response during the next 6 days, as did 20% of the other patients. Headache was the most frequently reported adverse event (18%), followed by constipation (6%) and dizziness (4%). All adverse events were mild and occurred equally frequently at both dose levels. Granisetron at 40 micrograms/kg i.v. given once is effective in the prevention of acute chemotherapy-induced emesis and nausea, in particular in patients receiving moderately emetogenic therapy.

  11. Platinum Concentration and Pathologic Response to Cisplatin-Based Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer.

    Directory of Open Access Journals (Sweden)

    Elizabeth A Guancial

    Full Text Available Platinum (Pt-based chemotherapy is the standard of care for muscle-invasive bladder cancer (MIBC. However, resistance is a major limitation. Reduced intratumoral drug accumulation is an important mechanism of platinum resistance. Our group previously demonstrated a significant correlation between tissue Pt concentration and tumor response to Pt-based neoadjuvant chemotherapy (NAC in lung cancer. We hypothesized that increased Pt concentration in radical cystectomy (RC specimens would correlate with improved pathologic response to Pt-based NAC in MIBC.A cohort of 19 clinically annotated, archived, fresh frozen RC specimens from patients with MIBC treated with Pt-based NAC was identified [ypT0 (pathologic complete response, pCR, N = 4; ≤ypT1N0M0 (pathologic partial response, pPR, N = 6; ≥ypT2 (minimal pathologic response/progression, N = 9]. RC specimens from 2 patients with MIBC who did not receive NAC and 1 treated with a non-Pt containing NAC regimen were used as negative controls. Total Pt concentration in normal adjacent urothelial tissue and bladder tumors from RC specimens was measured by flameless atomic absorption spectrophotometry.Total Pt concentration in normal urothelium differed by tumor pathologic response (P = 0.011. Specimens with pCR had the highest Pt concentrations compared to those with pPR (P = 0.0095 or no response/progression (P = 0.020. There was no significant difference in Pt levels in normal urothelium and tumor between pPR and no response/progression groups (P = 0.37; P = 0.25, respectively.Our finding of increased intracellular Pt in RC specimens with pCR following NAC for MIBC compared to those with residual disease suggests that enhanced Pt accumulation may be an important determinant of Pt sensitivity. Factors that modulate intracellular Pt concentration, such as expression of Pt transporters, warrant further investigation as predictive biomarkers of response to Pt-based NAC in MIBC.

  12. Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy. (United States)

    Fung, Chunkit; Sesso, Howard D; Williams, Annalynn M; Kerns, Sarah L; Monahan, Patrick; Abu Zaid, Mohammad; Feldman, Darren R; Hamilton, Robert J; Vaughn, David J; Beard, Clair J; Kollmannsberger, Christian K; Cook, Ryan; Althouse, Sandra; Ardeshir-Rouhani-Fard, Shirin; Lipshultz, Steve E; Einhorn, Lawrence H; Fossa, Sophie D; Travis, Lois B


    Purpose To provide new information on adverse health outcomes (AHOs) in testicular cancer survivors (TCSs) after four cycles of etoposide and cisplatin (EPX4) or three or four cycles of bleomycin, etoposide, cisplatin (BEPX3/BEPX4). Methods Nine hundred fifty-two TCSs > 1 year postchemotherapy underwent physical examination and completed a questionnaire. Multinomial logistic regression estimated AHOs odds ratios (ORs) in relation to age, cumulative cisplatin and/or bleomycin dose, time since chemotherapy, sociodemographic factors, and health behaviors. Results Median age at evaluation was 37 years; median time since chemotherapy was 4.3 years. Chemotherapy consisted largely of BEPX3 (38.2%), EPX4 (30.9%), and BEPX4 (17.9%). None, one to two, three to four, or five or more AHOs were reported by 20.4%, 42.0%, 25.1%, and 12.5% of TCSs, respectively. Median number after EPX4 or BEPX3 was two (range, zero to nine and zero to 11, respectively; P > .05) and two (range, zero to 10) after BEPX4. When comparing individual AHOs for EPX4 versus BEPX3, Raynaud phenomenon (11.6% v 21.4%; P < .01), peripheral neuropathy (29.2% v 21.4%; P = .02), and obesity (25.5% v 33.0%; P = .04) differed. Larger cumulative bleomycin doses (OR, 1.44 per 90,000 IU) were significantly associated with five or more AHOs. Increasing age was a significant risk factor for one to two, three to four, or five or more AHOs versus zero AHOs (OR, 1.22, 1.50, and 1.87 per 5 years, respectively; P < .01); vigorous physical activity was protective (OR, 0.62, 0.51, and 0.41, respectively; P < .05). Significant risk factors for three to four and five or more AHOs included current (OR, 3.05 and 3.73) or former (OR, 1.61 and 1.76) smoking ( P < .05). Self-reported health was excellent/very good in 59.9% of TCSs but decreased as AHOs increased ( P < .001). Conclusion Numbers of AHOs after EPX4 or BEPX3 appear similar, with median follow-up of 4.3 years. A healthy lifestyle was associated with reduced number of AHOs.

  13. Cisplatin-based chemotherapy followed by focal, reduced-dose irradiation for pediatric primary central nervous system germinomas. (United States)

    Douglas, James G; Rockhill, Jason K; Olson, James M; Ellenbogen, Richard G; Geyer, J Russell


    The objective of this study was to evaluate retrospectively one institution's experience treating pediatric central nervous system (CNS) pure germinomas with platinum-based chemotherapy followed by focal, reduced-dose irradiation. Eight patients were identified with localized, pure CNS germinomas from 1993 to 2004 at the authors' institution. The median age at diagnosis was 13 years (range 7-19). The median follow-up was 40 months (range 8-141). The tumor location was suprasellar in four, the pineal region in three, and the third ventricle in one. Irradiation was started a median of 20 weeks (range 17-22) from diagnosis and consisted of conformal fields to the primary site as determined by the initial diagnostic MR plus a 1.5- to 2-cm margin. Six of the eight patients received a dose of 3,060 cGy; two patients received 3,600 cGy. The 5-year actuarial event free survival was 71% (56-86%, 95% CI). Two patients suffered marginal (at field edge) failures and both were salvaged using reinduction platinum-based chemotherapy followed by cranial spinal irradiation and a boost to the primary tumor. The 5-year actuarial overall survival was 100%. There were no spinal failures. These data suggest that a reduction in both volume and dose (30.6-36 Gy) retains the excellent survival rates for patients with localized, pure germinomas of the CNS. A higher rate of ventricular relapse rate is observed, although salvage of those patients is feasible.

  14. High-grade acute organ toxicity as positive prognostic factor in primary radio(chemo)therapy for locally advanced, inoperable head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, Hendrik Andreas; Bosch, Jan; Hennies, Steffen; Hess, Clemens F.; Christiansen, Hans [Dept. of Radiotherapy and Radiooncology, Univ. Medicine Goettingen (Germany); Jung, Klaus [Dept. of Medical Statistics, Univ. Medicine Goettingen (Germany); Overbeck, Tobias [Dept. of Haematology and Oncology, Univ. Medicine Goettingen (Germany); Matthias, Christoph; Roedel, Ralph M. [Dept. of Otorhinolaryngology, Univ. Medicine Goettingen (Germany)


    Purpose: to test for a possible correlation between high-grade acute organ toxicity during primary radio(chemo)therapy and treatment outcome in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Patients and methods: from 05/1994 to 01/2009, 216 HNSCC patients were treated with radio(chemo)therapy in primary approach. They received normofractionated (2 Gy/fraction) irradiation including associated nodal drainage sites to a cumulative dose of 70 Gy. 151 patients received additional concomitant chemotherapy (111 patients 5-fluorouracil/mitomycin C, 40 patients cisplatin-based). Toxicity during treatment was monitored weekly according to the Common Toxicity Criteria (CTC), and any toxicity grade CTC {>=} 3 of mucositis, dysphagia or skin reaction was assessed as high-grade acute organ toxicity for later analysis. Results: a statistically significant coherency between high-grade acute organ toxicity and overall survival as well as locoregional control was found: patients with CTC {>=} 3 acute organ toxicity had a 5-year overall survival rate of 4% compared to 8% in patients without (p < 0.01). Thereby, multivariate analyses revealed that the correlation was independent of other possible prognostic factors or factors that may influence treatment toxicity, especially concomitant chemotherapy and radiotherapy technique or treatment-planning procedure. Conclusion: these data indicate that normal tissue and tumor tissue may behave similarly with respect to treatment response, as high-grade acute organ toxicity during radio(chemo)therapy showed to be an independent prognostic marker in the own patient population. However, the authors are aware of the fact that a multivariate analysis in a retrospective study generally has statistical limitations. Therefore, their hypothesis should be further analyzed on biomolecular and clinical levels and other tumor entities in prospective trials. (orig.)

  15. Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy. (United States)

    Kuo, Macus Tien; Fu, Siqing; Savaraj, Niramol; Chen, Helen H W


    The high-affinity copper transporter (Ctr1; SCLC31A1) plays an important role in regulating copper homeostasis because copper is an essential micronutrient and copper deficiency is detrimental to many important cellular functions, but excess copper is toxic. Recent research has revealed that human copper homeostasis is tightly controlled by interregulatory circuitry involving copper, Sp1, and human (hCtr1). This circuitry uses Sp1 transcription factor as a copper sensor in modulating hCtr1 expression, which in turn controls cellular copper and Sp1 levels in a 3-way mutual regulatory loop. Posttranslational regulation of hCtr1 expression by copper stresses has also been described in the literature. Because hCtr1 can also transport platinum drugs, this finding underscores the important role of hCtr1 in platinum-drug sensitivity in cancer chemotherapy. Consistent with this notion is the finding that elevated hCtr1 expression was associated with favorable treatment outcomes in cisplatin-based cancer chemotherapy. Moreover, cultured cell studies showed that elevated hCtr1 expression can be induced by depleting cellular copper levels, resulting in enhanced cisplatin uptake and its cell-killing activity. A phase I clinical trial using a combination of trientine (a copper chelator) and carboplatin has been carried out with encouraging results. This review discusses new insights into the role of hCtr1 in regulating copper homeostasis and explains how modulating cellular copper availability could influence treatment efficacy in platinum-based cancer chemotherapy through hCtr1 regulation.

  16. Inverse Planned High-Dose-Rate Brachytherapy for Locoregionally Advanced Cervical Cancer: 4-Year Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Tinkle, Christopher L.; Weinberg, Vivian [Department of Radiation Oncology, University of California, San Francisco, California (United States); Chen, Lee-May [Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California (United States); Littell, Ramey [Gynecologic Oncology, The Permanente Medical Group, San Francisco, California (United States); Cunha, J. Adam M.; Sethi, Rajni A. [Department of Radiation Oncology, University of California, San Francisco, California (United States); Chan, John K. [Gynecologic Oncology, California Pacific Medical Center, San Francisco, California (United States); Hsu, I-Chow, E-mail: [Department of Radiation Oncology, University of California, San Francisco, California (United States)


    Purpose: Evaluate the efficacy and toxicity of image guided brachytherapy using inverse planning simulated annealing (IPSA) high-dose-rate brachytherapy (HDRB) boost for locoregionally advanced cervical cancer. Methods and Materials: From December 2003 through September 2009, 111 patients with primary cervical cancer were treated definitively with IPSA-planned HDRB boost (28 Gy in 4 fractions) after external radiation at our institution. We performed a retrospective review of our experience using image guided brachytherapy. Of the patients, 70% had a tumor size >4 cm, 38% had regional nodal disease, and 15% had clinically evident distant metastasis, including nonregional nodal disease, at the time of diagnosis. Surgical staging involving pelvic lymph node dissection was performed in 15% of patients, and 93% received concurrent cisplatin-based chemotherapy. Toxicities are reported according to the Common Terminology Criteria for Adverse Events version 4.0 guidelines. Results: With a median follow-up time of 42 months (range, 3-84 months), no acute or late toxicities of grade 4 or higher were observed, and grade 3 toxicities (both acute and late) developed in 8 patients (1 constitutional, 1 hematologic, 2 genitourinary, 4 gastrointestinal). The 4-year Kaplan-Meier estimate of late grade 3 toxicity was 8%. Local recurrence developed in 5 patients (4 to 9 months after HDRB), regional recurrence in 3 (6, 16, and 72 months after HDRB), and locoregional recurrence in 1 (4 months after HDR boost). The 4-year estimates of local, locoregional, and distant control of disease were 94.0%, 91.9%, and 69.1%, respectively. The overall and disease-free survival rates at 4 years were 64.3% (95% confidence interval [CI] of 54%-73%) and 61.0% (95% CI, 51%-70%), respectively. Conclusions: Definitive radiation by use of inverse planned HDRB boost for locoregionally advanced cervical cancer is well tolerated and achieves excellent local control of disease. However, overall

  17. Palonosetron for the prevention of chemotherapy-induced nausea and vomiting: approval and efficacy

    Directory of Open Access Journals (Sweden)

    Rudolph M Navari


    Full Text Available Rudolph M NavariIndiana University School of Medicine South Bend, South Bend, IN USAAbstract: Chemotherapy-induced nausea and vomiting (CINV is associated with a significant deterioration in quality of life. The emetogenicity of the chemotherapeutic agents, repeated chemotherapy cycles, and patient characteristics (female gender, younger age, low alcohol consumption, history of motion sickness are the major risk factors for CINV. This review provides a detailed description of palonosetron, a second-generation 5-hydroxytryptamine 3 (5-HT3 receptor antagonist. The chemistry and pharmacology of palonosetron are described, as well as the initial and recent clinical trials. Palonosetron has a longer half-life and a higher binding affinity than the first-generation 5-HT3 receptor antagonists. Palonosetron has been approved for the prevention of acute CINV in patients receiving either moderately or highly emetogenic chemotherapy and for the prevention of delayed CINV in patients receiving moderately emetogenic chemotherapy. In recent studies, compared to the first-generation 5-HT3 receptor antagonists, palonosetron in combination with dexamethasone demonstrated better control of delayed CINV in patients receiving highly emetogenic chemotherapy. There were no clinically relevant adverse reactions reported in the palonosetron clinical trials which were different from the common reactions reported for the 5-HT3 receptor antagonist class. Due to its efficacy in controlling both acute and delayed CINV, palonosetron may be very effective in the clinical setting of multiple-day chemotherapy and bone marrow transplantation.Keywords: anti-emetics, chemotherapy-induced nausea and vomiting, serotonin receptor antagonists, palonosetron

  18. Cisplatin-DNA adduct formation in patients treated with cisplatin-based chemoradiation: lack of correlation between normal tissues and primary tumor.

    NARCIS (Netherlands)

    Hoebers, F.J.; Pluim, D.; Hart, A.A.M.; Verheij, M.; Balm, A.J.M.; Fons, G.; Rasch, C.R.; Schellens, J.H.M.; Stalpers, L.J.A.; Bartelink, H.; Begg, A.C.


    PURPOSE: In this study, the formation of cisplatin-DNA adducts after concurrent cisplatin-radiation and the relationship between adduct-formation in primary tumor tissue and normal tissue were investigated. METHODS: Three intravenous cisplatin-regimens, given concurrently with radiation, were studie

  19. Cisplatin-DNA adduct formation in patients treated with cisplatin-based chemoradiation: lack of correlation between normal tissues and primary tumor

    NARCIS (Netherlands)

    Hoebers, F.J.P.; Pluim, D.; Hart, A.A.M.; Verheij, M.; Balm, A.J.M.; Fons, G.; Rasch, C.R.N.; Schellens, J.H.M.; Stalpers, L.J.A.; Bartelink, H.; Begg, A.C.


    Purpose: In this study, the formation of cisplatin-DNA adducts after concurrent cisplatin-radiation and the relationship between adduct-formation in primary tumor tissue and normal tissue were investigated. Methods: Three intravenous cisplatin-regimens, given concurrently with radiation, were stu

  20. Clinical Significance of Early Changes in Circulating Tumor Cells from Patients Receiving First-Line Cisplatin-Based Chemotherapy for Metastatic Urothelial Carcinoma1 (United States)

    Fina, Emanuela; Necchi, Andrea; Giannatempo, Patrizia; Colecchia, Maurizio; Raggi, Daniele; Daidone, Maria Grazia; Cappelletti, Vera


    Background: The therapeutic paradigm of metastatic urothelial carcinoma (UC) is rapidly shifting and new biomarkers are needed to enhance patient selection. Objective: Early identification of dynamic predictors of outcome may be a key to optimize the sequence of effective therapies in metastatic UC patients. Methods: Blood samples from patients receiving first-line MVAC chemotherapy were collected at baseline (T0) and after 2 cycles (T2). Samples were processed by immunomagnetic beads (AdnaTest ProstateCancerSelect kit) and the expression of EPCAM, MUC1 and ERBB2 was studied using multiplex-PCR. Circulating tumor cell (CTC) positivity and cutoffs, obtained by receiver operator characteristic (ROC) curve analysis in healthy donors, were: ≥1 positive marker among EPCAM (≥0.40 ng/μl), MUC1 (≥0.10 ng/μl) and ERBB2 (≥0.20 ng/μl). CTC variation (T0/T2) was split in favorable (+/–, –/–, –/+) and unfavorable groups (+/+). Cox regression analyses evaluated associations with clinical factors. Results: In this pilot study to assess a new CTC detection method, among 31 evaluable patients, 17 (54.8%) were CTC-positive at T0. No association was found between CTC and objective response to MVAC. CTC dynamic changes better predicted 3-year progression-free (PFS) and overall survival (OS) compared to CTC status assessed at single time points. Unfavorable trend was univariably detrimental on 3-year PFS (10% vs. 49.2%, p = 0.006) and OS (20% vs. 63.5%, p = 0.017). Significance was maintained after controlling for liver metastases (p = 0.031 and p = 0.025 for PFS and OS) and MSKCC score (p = 0.014 and 0.025). Conclusions: Newly described early CTC changes during chemotherapy might be useful to improve our prognostic ability. Pending validation, these results could fulfill the promise to help accelerating therapeutic sequences. PMID:28035320

  1. Practical use of perioperative chemotherapy for muscle-invasive bladder cancer: summary of session at the Society of Urologic Oncology annual meeting. (United States)

    Apolo, Andrea B; Grossman, Herbert Barton; Bajorin, Dean; Steinberg, Gary; Kamat, Ashish M


    At the 11th annual meeting of the Society of Urologic Oncology, an expert panel was convened to discuss the practical use of perioperative chemotherapy for muscle-invasive bladder cancer. The discussion was structured as a case-based debate among the panelists. The topics included: neoadjuvant chemotherapy with a focus on T2 disease, pros and cons, survival data, tolerability of cisplatin-based therapy, can we avoid radical cystectomy in complete responders, limitations and alternatives to cisplatin-based therapy, management of 'suboptimal' chemotherapy, residual disease after neoadjuvant chemotherapy, adjuvant chemotherapy, and key aspects of radical cystectomy and lymph-node dissection in multimodal therapy. The presentations were derived from published literature. The panelists agreed that patients with muscle-invasive bladder cancer should be managed with a multidisciplinary team, including urologist and medical oncologist. Cisplatin-based neoadjuvant chemotherapy has demonstrated improved survival and should be incorporated into the management of all eligible patients with muscle-invasive bladder cancer. However, in some centers, neoadjuvant chemotherapy is reserved for patients with >T2 disease or high-risk features. There are no data for the administration of non-cisplatin-based neoadjuvant chemotherapy, such as carboplatin-combinations. Cisplatin-ineligible patients should proceed directly to surgical extirpation with adjuvant cisplatin-based chemotherapy considered based on pathologic findings. However, the data for adjuvant chemotherapy is less compelling. As our refinement of the selection process continues, we may be able to better identify subsets of patients who may be spared chemotherapy, but much work remains to be done in this arena. The current standard for muscle-invasive bladder cancer patients is cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy and pelvic lymph-node dissection.

  2. Long-Term and Late Effects of Germ Cell Testicular Cancer Treatment and Implications for Follow-Up

    NARCIS (Netherlands)

    Haugnes, Hege S.; Bosl, George J.; Boer, Hink; Gietema, Jourik A.; Brydoy, Marianne; Oldenburg, Jan; Dahl, Alv A.; Bremnes, Roy M.; Fossa, Sophie D.


    Germ cell testicular cancer (TC) represents a malignancy with high cure rates. Since the introduction of cisplatin-based chemotherapy in the late 1970s, the 5-year survival rate has increased considerably, and it is currently above 95%. Because TC is usually diagnosed before the age of 40 years, the

  3. Molecular determinants of treatment response in human germ cell tumors

    NARCIS (Netherlands)

    F. Mayer; J.A. Stoop (Hans); G.L. Scheffer (George); R. Scheper; J.W. Oosterhuis (Wolter); L.H.J. Looijenga (Leendert); C. Bokemeyer


    textabstractPURPOSE: Germ cell tumors (GCTs) are highly sensitive to cisplatin-based chemotherapy. This feature is unexplained, as is the intrinsic chemotherapy resistance of mature teratomas and the resistant phenotype of a minority of refractory GCTs. Various cellular pathways ma

  4. Explanation of the mechanism of carcinogenesis and syntheses of anticancer agents with high selectivity

    Institute of Scientific and Technical Information of China (English)


    patented new anticancer platinum complexes called di-regioplatins, based on the above predetermined design, have been reported. In these cancer cell kill rates, tumor-inhibition rates and the ultimate life-span for two mouse carcinoma models using several compounds of cis-di-substituted-benzylaminodihaloplatinum (II) are notably higher than those of cisplatin, but their toxicities all are much lower than cisplatin. Based on a predictive design using di-region theory and group theory, a new anticancer complex, cis-diammine-cyclopentane-1,1-dicarboxylato- platinum (II) called minoplatin, has been synthesized in this laboratory by making the minimal structural revision of adding an CH2 unit on the four-member ring of carboplatin.The water solubility of minoplatin is almost double that of carboplatin, yet its lipid solubility is much higher than carboplatin. Animal acute toxicity of minoplatin is only half that of carboplatin, and the curative effect of minoplatin in a rapid growing animal tumor model of the ascites-type is remarkably higher than that of carboplatin. Genetic toxicity of minoplatin as measured by reverse mutagenesis with the TA 102 strain is only 1/200 of cisplatin and 1/10 of carboplatin. Minoplatin, as opposed to cisplatin, shows no teratogenesis to the offspring of pregnant female mice. Additionally, some recent empirical research results on anticancer platinum complexes have been explained by the di-region theory, and comments from the perspective of predicting the selectivity of anticancer agents have been presented. We anticipate that future clinical testing will demonstrate that minoplatin and di-regioplatins are the first examples in a class consisting of highly selective, low toxicity, and tailored second generation anticancer agents.

  5. High arch (United States)

    Pes cavus; High foot arch ... High foot arches are much less common than flat feet. They are more likely to be caused ... difficult to fit into shoes. People who have high arches most often need foot support. A high ...

  6. Safety and efficacy of aprepitant for chemotherapy-induced nausea and vomiting in pediatric patients: a prospective, observational study. (United States)

    Bodge, Megan; Shillingburg, Alexandra; Paul, Stephan; Biondo, Lisa


    Pediatric patients between the ages of 12 months and 17 years with a confirmed malignancy who were scheduled to receive aprepitant as part of triple therapy antiemetic prophylaxis for a cycle of moderately- or highly emetogenic chemotherapy were eligible for enrollment. Patients were evaluated for the incidence of nausea, episodes of emesis, interference with activities of daily living (ADLs), and appetite through utilization of a patient survey. Eleven patients were enrolled for a total of 20 patient encounters, mean age 9.55 ± 4.85 (range, 12 months-17 years). Aprepitant was well-tolerated and complete response (CR) rate was 38.9%.

  7. Computational prediction of state anxiety in Asian patients with cancer susceptible to chemotherapy-induced nausea and vomiting. (United States)

    Yap, Kevin Yi-Lwern; Low, Xiu Hui; Chui, Wai Keung; Chan, Alexandre


    State anxiety, a risk factor for chemotherapy-induced nausea and vomiting (CINV), is a subjective symptom and difficult to quantify. Clinicians need appropriate anxiety measures to assess patients' risks of CINV. This study aimed to determine the anxiety characteristics that can predict CINV based on computational analysis of an objective assessment tool. A single-center, prospective, observational study was carried out between January 2007 and July 2010. Patients with breast, head and neck, and gastrointestinal cancers were recruited and treated with a variety of chemotherapy protocols and appropriate antiemetics. Chemotherapy-induced nausea and vomiting characteristics and antiemetic use were recorded using a standardized diary, whereas patients' anxiety characteristics were evaluated using the Beck Anxiety Inventory. Principal component (PC) analysis was performed to analyze the anxiety characteristics. A subset known as principal variables, which had the highest PC weightings, was identified for patients with and without complete response, complete protection, and complete control. Chemotherapy-induced nausea and vomiting events and anxiety characteristics of 710 patients were collated; 51%, 30%, and 20% were on anthracycline-, oxaliplatin-, and cisplatin-based therapies, respectively. Most patients suffered from delayed CINV, with decreasing proportions achieving complete response (58%), complete protection (42%), and complete control (27%). Seven symptoms (fear of dying, fear of the worst, unable to relax, hot/cold sweats, nervousness, faintness, numbness) were identified as potential CINV predictors. This study demonstrates the usefulness of PC analysis, an unsupervised machine learning technique, to identify 7 anxiety characteristics that are useful as clinical CINV predictors. Clinicians should be aware of these characteristics when assessing CINV in patients on emetogenic chemotherapies.

  8. High PRF high current switch (United States)

    Moran, Stuart L.; Hutcherson, R. Kenneth


    A triggerable, high voltage, high current, spark gap switch for use in pu power systems. The device comprises a pair of electrodes in a high pressure hydrogen environment that is triggered by introducing an arc between one electrode and a trigger pin. Unusually high repetition rates may be obtained by undervolting the switch, i.e., operating the trigger at voltages much below the self-breakdown voltage of the device.

  9. High Surplus Means High Profits?

    Institute of Scientific and Technical Information of China (English)

    Guo Yan


    @@ In recent years,China has been in the limelight worldwide due to its constant high trade surplus.Its trade surplus hit US$ 24.974 billion in August, a record high and an increase of US$ 624 million versus the previous month, according to the latest data from China Customs.

  10. High Tech


    Manterola, Javier; Fernández Casado, S.A., Carlos


    "High Tech" is an architectural movement that emphasizes the technological dimension of the building as expression means. Its research includes the diverse structures composing the building: resistance, closing, services, distribution and communications. Its results are unequal since not all the buildings rising from this movement are high technology and already are other buildings not enrolled in this movement. Renzo Piano, Richard Rogers and Norman Foster are its main representatives.

  11. Highly efficient high temperature electrolysis

    DEFF Research Database (Denmark)

    Hauch, Anne; Ebbesen, Sune; Jensen, Søren Højgaard;


    High temperature electrolysis of water and steam may provide an efficient, cost effective and environmentally friendly production of H-2 Using electricity produced from sustainable, non-fossil energy sources. To achieve cost competitive electrolysis cells that are both high performing i.e. minimum...... internal resistance of the cell, and long-term stable, it is critical to develop electrode materials that are optimal for steam electrolysis. In this article electrolysis cells for electrolysis of water or steam at temperatures above 200 degrees C for production of H-2 are reviewed. High temperature...... electrolysis is favourable from a thermodynamic point of view, because a part of the required energy can be supplied as thermal heat, and the activation barrier is lowered increasing the H-2 production rate. Only two types of cells operating at high temperature (above 200 degrees C) have been described...

  12. High Line

    DEFF Research Database (Denmark)

    Kiib, Hans


    At just over 10 meters above street level, the High Line extends three kilometers through three districts of Southwestern Manhattan in New York. It consists of simple steel construction, and previously served as an elevated rail line connection between Penn Station on 34th Street and the many....... The High Line project has been carried out as part of an open conversion strategy. The result is a remarkable urban architectural project, which works as a catalyst for the urban development of Western Manhattan. The greater project includes the restoration and reuse of many old industrial buildings...... in close proximity to the park bridge and new projects being added to fit the context. The outcome is a conglomeration of non-contemporary urban activities along the High Line, where mechanical workshops, small wholesale stores. etc. mix with new exclusive residential buildings, eminent cafés...

  13. High Line

    DEFF Research Database (Denmark)

    Kiib, Hans


    in close proximity to the park bridge and new projects being added to fit the context. The outcome is a conglomeration of non-contemporary urban activities along the High Line, where mechanical workshops, small wholesale stores. etc. mix with new exclusive residential buildings, eminent cafés......At just over 10 meters above street level, the High Line extends three kilometers through three districts of Southwestern Manhattan in New York. It consists of simple steel construction, and previously served as an elevated rail line connection between Penn Station on 34th Street and the many...... factories and warehouses on Gansevoort Street. Today the High Line is a beautiful park covered with new tiles, viewing platforms and smaller recreational areas. The park bridge has simple, uniform, urban fittings and features a variety of flowering plants, grasses, shrubs and trees from around the world...

  14. High Turbulence

    CERN Multimedia

    EuHIT, Collaboration


    As a member of the EuHIT (European High-Performance Infrastructures in Turbulence - see here) consortium, CERN is participating in fundamental research on turbulence phenomena. To this end, the Laboratory provides European researchers with a cryogenic research infrastructure (see here), where the first tests have just been performed.

  15. High Energy $\

    CERN Multimedia


    This experiment is a high statistics exposure of BEBC filled with hydrogen to both @n and &bar.@n beams. The principal physics aims are : \\item a) The study of the production of charmed mesons and baryons using fully constrained events. \\end{enumerate} b) The study of neutral current interactions on the free proton. \\item c) Measurement of the cross-sections for production of exclusive final state N* and @D resonances. \\item d) Studies of hadronic final states in charged and neutral current reactions. \\item e) Measurement of inclusive charged current cross-sections and structure functions. \\end{enumerate}\\\\ \\\\ The neutrino flux is determined by monitoring the flux of muons in the neutrino shield. The Internal Picket Fence and External Muon Identifier of BEBC are essential parts of the experiment. High resolution cameras are used to search for visible decays of short-lived particles.

  16. High efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, G.


    The surgeon wants to have phlebograms with good contrast, which should show only the deep venous system and leaks to the superficial system, that means, the insufficient communicating veins and the inflow of the big and small saphenous vein into the deep vein must be visible. The most frequent causes for X-ray-prints of bad quality are: a too high position of the stowing, too high puncture at the back of the foot, bad focussing without showing the ankle joint or the popliteal region and too narrow sections of the X-ray-films as well as too late exposures with fullfilling of the total superficial venous system and extreme superposition on the film.

  17. High Tech

    Directory of Open Access Journals (Sweden)

    Manterola, Javier


    Full Text Available "High Tech" is an architectural movement that emphasizes the technological dimension of the building as expression means. Its research includes the diverse structures composing the building: resistance, closing, services, distribution and communications. Its results are unequal since not all the buildings rising from this movement are high technology and already are other buildings not enrolled in this movement. Renzo Piano, Richard Rogers and Norman Foster are its main representatives.

    "High Tech" es un movimiento arquitectónico que enfatiza la dimensión tecnológica del edificio como medio de expresión. Su investigación se fija en las diversas estructuras que configuran el edificio, la resistente, la de cerramiento, la de servicios, la de distribución y comunicaciones. Sus resultados son desiguales pues no todos los edificios que surgen de este movimiento son alta tecnología y muchos otros no inscritos en dicho movimiento sí lo son. Renzo Piano, Richard Rogers y Norman Foster son sus representantes más destacados.

  18. Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: a pilot study (United States)

    Danwilai, Kwanjit; Konmun, Jitprapa; Sripanidkulchai, Bung-orn; Subongkot, Suphat


    Purpose The aim of this study was to examine the antioxidant activity of ginger extract oral supplement in newly diagnosed cancer patients receiving adjuvant chemotherapy compared to placebo. Patients and methods Newly diagnosed cancer patients receiving moderate-to-high emetogenic potential adjuvant chemotherapy were randomized to receive either a ginger extract (standardized 6-gingerol 20 mg/day) or a placebo 3 days prior to chemotherapy, which they continued daily. Oxidant/antioxidant parameters, including the activities of superoxide dismutase (SOD) and catalase (CAT) and levels of glutathione peroxidase (GPx), total glutathione (GSH/GSSG), lipid peroxidation products detected as malondialdehyde (MDA) and NO2−/NO3−, were measured at baseline and at days 1, 22, 43 and 64 after undergoing chemotherapy. Two-sided statistical analysis, with P ginger group and placebo group, respectively. Antioxidant activity parameters, including SOD, CAT, GPx and GSH/GSSG, were significantly increased at day 64 in the ginger group compared to those in the placebo group, while MDA and NO2−/NO3− levels were significantly decreased (P ginger extract started 3 days prior to chemotherapy has been shown to significantly elevate antioxidant activity and reduce oxidative marker levels in patients who received moderate-to-high emetogenic potential chemotherapy compared to placebo. PMID:28203106

  19. [Treatment of testicular cancer]. (United States)

    Droz, Jean-Pierre; Boyle, Helen; Culine, Stéphane; Fizazi, Karim; Fléchon, Aude; Massard, Christophe


    Germ-cell tumours (GCTs) are the most common type of cancer in young men. Since the late 1970s, disseminated GCT have been a paradigm for curable metastatic cancer and metastatic GCTs are highly curable with cisplatin-based chemotherapy followed by surgical resection of residual masses. Patients' prognosis is currently assessed using the International Germ-Cell Consensus Classification (IGCCC) and used to adapt the burden of chemotherapy. Approximately 20% of patients still do not achieve cure after first-line cisplatin-based chemotherapy, and need salvage chemotherapy (high dose or standard dose chemotherapy). Clinical stage I testicular cancer is the most common presentation and different strategies are proposed: adjuvant therapies, surgery or surveillance. During the last three decades, clinical trials and strong international collaborations lead to the development of a consensus in the management of GCTs.

  20. Prevention of acute chemotherapy-induced nausea and vomiting: the role of palonosetron

    Directory of Open Access Journals (Sweden)

    Emilio Bajetta


    Full Text Available Emilio Bajetta, Sara Pusceddu, Valentina Guadalupi, Monika Ducceschi, Luigi CelioMedical Oncology Unit 2, Fondazione IRCCS “Istituto Nazionale dei Tumori”, Milan, ItalyAbstract: Prevention of nausea and vomiting is the main goal of antiemetic treatment in cancer patients scheduled to receive chemotherapy. To prevent acute emesis, antiemetics should be administered just before chemotherapy and patients should be protected for up to 24 hours after chemotherapy initiation. The emetogenic potential of chemotherapeutic agents guides clinicians towards the most appropriate antiemetic prophylaxis. Current guidelines recommend the use of 5-HT3 receptor antagonist (RA either alone or in combination with dexamethasone and/or a neurokinin-1 RA both in the acute and delayed phases. The second-generation 5-HT3RA palonosetron exhibits a longer half-life and a higher binding affinity than older antagonists. Palonosetron has been approved by the FDA for the prevention of chemotherapy-induced nausea and vomiting (CINV in patients scheduled to receive either moderately (MEC or highly emetogenic chemotherapy (HEC and for the prevention of delayed CINV in patients receiving MEC. The present review will discuss the role of palonosetron in the prevention of acute CINV.Keywords: antiemetics, chemotherapy, nausea, vomiting, serotonin-receptor antagonists, palonosetron

  1. Prognostic Value of p16 Status on the Development of a Complete Response in Involved Oropharynx Cancer Neck Nodes After Cisplatin-Based Chemoradiation: A Secondary Analysis of NRG Oncology RTOG 0129 (United States)

    Galloway, Thomas J.; Zhang, Qiang; Nguyen-Tan, Phuc Felix; Rosenthal, David I.; Soulieres, Denis; Fortin, André; Silverman, Craig L.; Daly, Megan E.; Ridge, John A.; Hammond, J. Alexander; Le, Quynh-Thu


    Purpose To determine the relationship between p16 status and the regional response of patients with node-positive oropharynx cancer treated on NRG Oncology RTOG 0129. Methods and Materials Patients with N1-N3 oropharynx cancer and known p16 status who underwent treatment on RTOG 0129 were analyzed. Pathologic complete response (pCR) rates in patients treated with a postchemoradiation neck dissection (with p16-positive or p16-negative cancer) were compared by Fisher exact test. Patients managed expectantly were compared with those treated with a neck dissection. Results Ninety-nine (34%) of 292 patients with node-positive oropharynx cancer and known p16 status underwent a posttreatment neck dissection (p16-positive: n = 69; p16-negative: n = 30). The remaining 193 patients with malignant lymphadenopathy at diagnosis were observed. Neck dissection was performed a median of 70 (range, 17-169) days after completion of chemoradiation. Neither the pretreatment nodal stage (P = .71) nor the postradiation, pre-neck dissection clinical/radiographic neck assessment (P = .42) differed by p16 status. A pCR was more common among p16-positive patients (78%) than p16-negative patients (53%, P = .02) and was associated with a reduced incidence of local–regional failure (hazard ratio 0.33, P = .003). On multivariate analysis of local–regional failure, a test for interaction between pCR and p16 status was not significant (P = .37). One-hundred ninety-three (66%) of 292 of initially node-positive patients were managed without a posttreatment neck dissection. Development of a clinical (cCR) was not significantly influenced by p16-status (P = .42). Observed patients with a clinical nodal CR had disease control outcomes similar to those in patients with a pCR neck dissection. Conclusions Patients with p16-positive tumors had significantly higher pCR and locoregional control rates than those with p16-negative tumors. PMID:27478170

  2. 经典顺铂类抗肿瘤药物耐药性研究综述%The Review:Recent Research in Drug Resistance of Classic Cisplatin-Based Drugs

    Institute of Scientific and Technical Information of China (English)

    高传柱; 费凡; 王天帅; 杨波; 杨健; 廖霞俐


    As a class of cell cycle non -specific anticancer drugs with a unique structure -activity,Cisplatin shows good efficacy in the clinical treatment of ovarian cancer,prostate cancer,testicular cancer and other solid tumors.However,resistance or cross-resistance of the cisplatin analogous is becoming one of the main obstacles for cisplatin and its analogous,which limits their clinical applications.Understanding the resistance mechanisms of the classic platinum-based anticancer drugs not only helps doctors in clinical applications,but also gives us more targeted information in rational drug design to obtain novel platinum-based drugs with better efficacy and lower toxicity.This paper reviews research progress of the classic cisplatin analgous for their drug resistance mechanisms.%作为一类具有独特构效关系的细胞周期非特异性抗肿瘤药物,顺铂在临床治疗卵巢癌、前列腺癌、睾丸癌等实体肿瘤中显示了良好的疗效。然而,经典顺铂类抗肿瘤药物结构上的相似性使得耐药性或交叉耐药性成为限制该类药物临床应用的主要障碍之一。通过对经典铂类抗肿瘤药物耐药机制的研究和探讨,不仅可以指导已上市铂类药物的临床使用,而且能够有效地针对其耐药机制的产生来进行更为合理的药物设计和结构修饰改造,从而获得具有更好疗效、更低毒副作用的新型铂类抗肿瘤药物。

  3. Rapidly alternating combination of cisplatin-based chemotherapy and hyperfractionated accelerated radiotherapy in split course for Stage IIIA and Stage IIIB non-small cell lung cancer: results of a Phase I-II study by the GOTHA group

    Energy Technology Data Exchange (ETDEWEB)

    Alberto, P.; Mermillod, B. [Hopital Cantonal Geneve, Geneva (Switzerland); Mirimanoff, R.O.; Leyvraz, S.; Nagy-Mignotte, H.; Bolla, M.; Wellmann, D.; Moro, D.; Brambilla, E. [Hopital Cantonal Universitaire, Lausanne (Switzerland)


    The prognosis of stage III non-small cell lung cancer (NSCLC) can be improved by a combination of radiotherapy (RT) and chemotherapy (CT). In this study, the GOTHA group evaluated the feasibility, tolerance, tumour response, pattern of failure and effect on survival of a combination alternating accelerated hyperfractionated (AH) RT and CT in patients with tumour stage III NSCLC. Toxic effects were leucopenia, nausea and vomiting, mucositis, diarrhoea, alopecia and peripheral neuropathy. Alternating CT and AHRT, as used in this study, were well tolerated and allowed full dose delivery within less than 12 weeks. Initial response was not predictive of survival. The survival curve is encouraging and the 5 year survival is superior to the 5% generally observed with conventionally fractionated radiotherapy. (author).

  4. Role of neurofilament light polypeptide in head and neck cancer chemoresistance. (United States)

    Chen, Baishen; Chen, Ju; House, Michael G; Cullen, Kevin J; Nephew, Kenneth P; Guo, Zhongmin


    Resistance to cisplatin-based chemotherapy is responsible for therapeutic failure of many common human cancers including cancer of head and neck (HNC). Mechanisms underlying cisplatin resistance remain unclear. In this study, we identified neurofilament light polypeptide (NEFL) as a novel hypermethylated gene associated with resistance to cisplatin-based chemotherapy in HNC. Analysis of 14 HNC cell lines revealed that downregulation of NEFL expression significantly correlated with increased resistance to cisplatin. Hypermethylation of NEFL promoter CpG islands was observed in cell lines as examined by bisulfite DNA sequencing and methylation-specific PCR (MSP) and tightly correlated with reduced NEFL mRNA and protein expression. Furthermore, in patient samples with HNC (n = 51) analyzed by quantitative MSP, NEFL promoter hypermethylation was associated with resistance to cisplatin-based chemotherapy [relative risk (RR), 3.045; 95% confidence interval (CI), 1.459-6.355; P = 0.007] and predicted diminished overall and disease-free survival for patients treated with cisplatin-based chemotherapy. Knockdown of NEFL by siRNA in the highly cisplatin-sensitive cell line PCI13 increased (P cells, restored expression of NEFL significantly increased sensitivity to the drug. Furthermore, NEFL physically associated with tuberous sclerosis complex 1 (TSC1), a known inhibitor of the mTOR pathway, and NEFL downregulation led to functional activation of mTOR pathway and consequentially conferred cisplatin resistance. This is the first study to show a role for NEFL in HNC chemoresistance. Our findings suggest that NEFL methylation is a novel mechanism for HNC chemoresistance and may represent a candidate biomarker predictive of chemotherapeutic response and survival in patients with HNC.

  5. High Combustion Research Facility (United States)

    Federal Laboratory Consortium — At NETL's High-Pressure Combustion Research Facility in Morgantown, WV, researchers can investigate new high-pressure, high-temperature hydrogen turbine combustion...

  6. Palonosetron in the prevention of chemotherapy-induced nausea and vomiting: an evidence-based review of safety, efficacy, and place in therapy

    Directory of Open Access Journals (Sweden)

    Celio L


    Full Text Available Luigi Celio, Monica Niger, Francesca Ricchini, Francesco Agustoni Medical Oncology Unit 1, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Introduction: The second-generation 5-hydroxytryptamine-3 (5-HT3 receptor antagonist palonosetron is effective in the prevention of chemotherapy-induced nausea and vomiting (CINV associated with highly and moderately emetogenic chemotherapy (HEC and MEC, respectively. In addition, palonosetron has been the first and, at present, the only 5-HT3 receptor antagonist to have a specific indication for the prevention of delayed CINV associated with MEC. The unique pharmacology of this antagonist is thought to partly explain its improved efficacy against delayed symptoms. Aims: To review the evidence underlying the use of palonosetron in preventing CINV. Evidence review: A recent meta-analysis consistently showed that palonosetron significantly increases the control of both emesis and nausea during the acute and delayed phases after single-day HEC or MEC. Consistent with these findings from trials that did not include an neurokinin-1 (NK-1 receptor antagonist, randomized controlled trials recently showed that a triple combination with palonosetron achieves significantly better control of delayed CINV, particularly delayed nausea, in patients undergoing HEC or the high-risk combination of an anthracycline and cyclophosphamide (AC. Evidence from randomized studies also supports palonosetron as a valuable option to reduce the total corticosteroid dose administered in patients undergoing multiple cycles of MEC or AC chemotherapy. Additional benefits of palonosetron include the lack of a warning on cardiac safety and no known clinically significant drug–drug interactions. Place in therapy and conclusion: Evidence currently available indicates that palonosetron significantly adds to the clinician’s ability to effectively control CINV in patients undergoing HEC or MEC. It is

  7. Hypertension (High Blood Pressure) (United States)

    ... Surgery? A Week of Healthy Breakfasts Shyness Hypertension (High Blood Pressure) KidsHealth > For Teens > Hypertension (High Blood Pressure) Print ... rest temperature diet emotions posture medicines Why Is High Blood Pressure Bad? High blood pressure means a person's heart ...

  8. 2016 updated MASCC/ESMO consensus recommendations

    DEFF Research Database (Denmark)

    Einhorn, Lawrence H; Rapoport, Bernardo; Navari, Rudolph M;


    PURPOSE: This review summarizes the recommendations for the prophylaxis of acute and delayed nausea and vomiting induced by multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting as agreed at the MASCC/ESMO Antiemetic Guidelines update meeting in Copenhagen in June......-induced nausea and vomiting, a phase III randomized trial investigating the use of olanzapine versus metoclopramide in patients receiving highly emetogenic chemotherapy and a second single arm study looking at the effectiveness of olanzapine were identified. CONCLUSIONS: It was concluded that for patients...... receiving high-dose chemotherapy with stem cell transplant, a combination of a 5-HT3 receptor antagonist with dexamethasone and aprepitant (125 mg orally on day 1 and 80 mg orally on days 2 to 4) is recommended before chemotherapy. For patients undergoing multiple-day chemotherapy-induced nausea...

  9. Antioxidant activity of ginger extract as a daily supplement in cancer patients receiving adjuvant chemotherapy: a pilot study

    Directory of Open Access Journals (Sweden)

    Danwilai K


    Full Text Available Kwanjit Danwilai,1,2 Jitprapa Konmun,2,3 Bung-orn Sripanidkulchai,4 Suphat Subongkot,2,4,5 1Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 2The College of Pharmacotherapy of Thailand, Nonthaburi, 3Department of Pharmacy, Ramathibodi Hospital, Mahidol University, Bangkok, 4Center for Research and Development of Herbal Health Products, 5Clinical Pharmacy Division, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand Purpose: The aim of this study was to examine the antioxidant activity of ginger extract oral supplement in newly diagnosed cancer patients receiving adjuvant chemotherapy compared to placebo.Patients and methods: Newly diagnosed cancer patients receiving moderate-to-high emetogenic potential adjuvant chemotherapy were randomized to receive either a ginger extract (standardized 6-gingerol 20 mg/day or a placebo 3 days prior to chemotherapy, which they continued daily. Oxidant/antioxidant parameters, including the activities of superoxide dismutase (SOD and catalase (CAT and levels of glutathione peroxidase (GPx, total glutathione (GSH/GSSG, lipid peroxidation products detected as malondialdehyde (MDA and NO2-/NO3-, were measured at baseline and at days 1, 22, 43 and 64 after undergoing chemotherapy. Two-sided statistical analysis, with P < 0.05, was used to determine statistical significance.Results: A total of 43 patients were included in the study: 19 and 24 patients were randomly assigned to the ginger group and placebo group, respectively. Antioxidant activity parameters, including SOD, CAT, GPx and GSH/GSSG, were significantly increased at day 64 in the ginger group compared to those in the placebo group, while MDA and NO2-/NO3- levels were significantly decreased (P < 0.0001. When compared to the baseline, the activities of SOD and CAT and the levels of GPx and GSH/GSSG were significantly higher on day 64 (P = 0.01, while the blood levels of

  10. High-Altitude Illness (United States)

    ... also called HAPE), which affects the lungsHigh-altitude cerebral edema (also called HACE), which affects the brainThese illnesses ... HAPE, high altitude, high altitude sickness, high-altitude cerebral edema, high-altitude pulmonary edema, hypobaropathy, mountain sickness, nifedipine, ...

  11. High Blood Pressure (United States)

    ... normal blood pressure 140/90 or higher is high blood pressure Between 120 and 139 for the top number, ... prehypertension. Prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. High ...

  12. High Blood Pressure (Hypertension) (United States)

    ... Print Page Text Size: A A A Listen High Blood Pressure (Hypertension) Nearly 1 in 3 American adults has ... weight. How Will I Know if I Have High Blood Pressure? High blood pressure is a silent problem — you ...

  13. High blood sugar (United States)

    ... High blood glucose - self-care; Diabetes - high blood sugar ... Symptoms of high blood sugar can include: Being very thirsty or having a dry mouth Having blurry vision Having dry skin Feeling weak or tired ...

  14. High potassium level (United States)

    Hyperkalemia; Potassium - high; High blood potassium ... There are often no symptoms with a high level of potassium. When symptoms do occur, they may include: Nausea Slow, weak, or irregular pulse Sudden collapse, when the heartbeat gets too ...

  15. High Blood Cholesterol Prevention (United States)

    ... Million Hearts® WISEWOMAN Program Prevention and Management of High LDL Cholesterol: What You Can Do Recommend on ... like eating a healthy diet, can help prevent high cholesterol. High low-density lipoprotein (LDL) cholesterol increases ...

  16. High Blood Cholesterol (United States)

    ... version of this page please turn Javascript on. High Blood Cholesterol What is High Blood Cholesterol? What is Cholesterol? Cholesterol is a ... heart disease. If Your Blood Cholesterol Is Too High Too much cholesterol in your blood is called ...

  17. High Performance Networks for High Impact Science

    Energy Technology Data Exchange (ETDEWEB)

    Scott, Mary A.; Bair, Raymond A.


    This workshop was the first major activity in developing a strategic plan for high-performance networking in the Office of Science. Held August 13 through 15, 2002, it brought together a selection of end users, especially representing the emerging, high-visibility initiatives, and network visionaries to identify opportunities and begin defining the path forward.

  18. High-Flying High-Poverty Schools (United States)

    American Educator, 2013


    In discussing socioeconomic integration before audiences, the author is frequently asked: What about high-poverty schools that do work? Don't they suggest that economic segregation isn't much of a problem after all? High-poverty public schools that beat the odds paint a heartening story that often attracts considerable media attention. In 2000,…

  19. High speed, high current pulsed driver circuit

    Energy Technology Data Exchange (ETDEWEB)

    Carlen, Christopher R.


    Various technologies presented herein relate to driving a LED such that the LED emits short duration pulses of light. This is accomplished by driving the LED with short duration, high amplitude current pulses. When the LED is driven by short duration, high amplitude current pulses, the LED emits light at a greater amplitude compared to when the LED is driven by continuous wave current.

  20. High Throughput Facility (United States)

    Federal Laboratory Consortium — Argonne?s high throughput facility provides highly automated and parallel approaches to material and materials chemistry development. The facility allows scientists...

  1. High Temperature Materials Laboratory (United States)

    Federal Laboratory Consortium — The High Temperature Materials Lab provides the Navy and industry with affordable high temperature materials for advanced propulsion systems. Asset List: Arc Melter...

  2. High pressure, high current, low inductance, high reliability sealed terminals (United States)

    Hsu, John S [Oak Ridge, TN; McKeever, John W [Oak Ridge, TN


    The invention is a terminal assembly having a casing with at least one delivery tapered-cone conductor and at least one return tapered-cone conductor routed there-through. The delivery and return tapered-cone conductors are electrically isolated from each other and positioned in the annuluses of ordered concentric cones at an off-normal angle. The tapered cone conductor service can be AC phase conductors and DC link conductors. The center core has at least one service conduit of gate signal leads, diagnostic signal wires, and refrigerant tubing routed there-through. A seal material is in direct contact with the casing inner surface, the tapered-cone conductors, and the service conduits thereby hermetically filling the interstitial space in the casing interior core and center core. The assembly provides simultaneous high-current, high-pressure, low-inductance, and high-reliability service.

  3. High speed data converters

    CERN Document Server

    Ali, Ahmed MA


    This book covers high speed data converters from the perspective of a leading high speed ADC designer and architect, with a strong emphasis on high speed Nyquist A/D converters. For our purposes, the term 'high speed' is defined as sampling rates that are greater than 10 MS/s.

  4. High pressure technology 1994

    Energy Technology Data Exchange (ETDEWEB)

    Kapp, J.A.; Picqueuer, L.M. (eds.)


    This volume is divided into four sessions: fracture mechanics applications to high pressure vessels; high pressure code issues; high pressure design, analysis, and safety concerns; and military and other high pressure applications. Separate abstracts were prepared for eleven papers of this conference.

  5. Hypertension (High Blood Pressure) (United States)

    ... Loss Surgery? A Week of Healthy Breakfasts Shyness Hypertension (High Blood Pressure) KidsHealth > For Teens > Hypertension (High Blood Pressure) A ... rest temperature diet emotions posture medicines Why Is High Blood Pressure Bad? High blood pressure means a person's heart ...

  6. High speed high dynamic range high accuracy measurement system

    Energy Technology Data Exchange (ETDEWEB)

    Deibele, Craig E.; Curry, Douglas E.; Dickson, Richard W.; Xie, Zaipeng


    A measuring system includes an input that emulates a bandpass filter with no signal reflections. A directional coupler connected to the input passes the filtered input to electrically isolated measuring circuits. Each of the measuring circuits includes an amplifier that amplifies the signal through logarithmic functions. The output of the measuring system is an accurate high dynamic range measurement.

  7. High-current, high-frequency capacitors (United States)

    Renz, D. D.


    The NASA Lewis high-current, high-frequency capacitor development program was conducted under a contract with Maxwell Laboratories, Inc., San Diego, California. The program was started to develop power components for space power systems. One of the components lacking was a high-power, high-frequency capacitor. Some of the technology developed in this program may be directly usable in an all-electric airplane. The materials used in the capacitor included the following: the film is polypropylene, the impregnant is monoisopropyl biphenyl, the conductive epoxy is Emerson and Cuming Stycast 2850 KT, the foil is aluminum, the case is stainless steel (304), and the electrode is a modified copper-ceramic.

  8. High temperature, high power piezoelectric composite transducers. (United States)

    Lee, Hyeong Jae; Zhang, Shujun; Bar-Cohen, Yoseph; Sherrit, Stewart


    Piezoelectric composites are a class of functional materials consisting of piezoelectric active materials and non-piezoelectric passive polymers, mechanically attached together to form different connectivities. These composites have several advantages compared to conventional piezoelectric ceramics and polymers, including improved electromechanical properties, mechanical flexibility and the ability to tailor properties by using several different connectivity patterns. These advantages have led to the improvement of overall transducer performance, such as transducer sensitivity and bandwidth, resulting in rapid implementation of piezoelectric composites in medical imaging ultrasounds and other acoustic transducers. Recently, new piezoelectric composite transducers have been developed with optimized composite components that have improved thermal stability and mechanical quality factors, making them promising candidates for high temperature, high power transducer applications, such as therapeutic ultrasound, high power ultrasonic wirebonding, high temperature non-destructive testing, and downhole energy harvesting. This paper will present recent developments of piezoelectric composite technology for high temperature and high power applications. The concerns and limitations of using piezoelectric composites will also be discussed, and the expected future research directions will be outlined.

  9. Radiotherapy-induced emesis. An overview

    Energy Technology Data Exchange (ETDEWEB)

    Feyer, P.; Buchali, A.; Hinkelbein, M.; Budach, V. [Department Radiotherapy, Humboldt-University Berlin (Germany); Zimmermann, J.S. [Department Radiotherapy, Christian Albrechts-University Kiel (Germany); Titlbach, O.J. [Department of Medicine I, Hospital Friedrichshain, Berlin (Germany)


    Background: A significant number of patients receiving radiotherapy experience the distressing side effects of emesis and nausea. These symptoms are some of the most distressing problems for the patients influencing their quality of life. Methods: International study results concerning radiotherapy-induced emesis are demonstrated. A German multicenter questionnaire examining the strategies to prevent or to treat radiotherapy-induced nausea and emesis is presented. An international analysis concerning incidence of emesis and nausea in fractionated radiotherapy patients is discussed. Finally the consensus of the consensus conference on antiemetic therapy from the Perugia International Cancer Conference V is introduced. Results: Untreated emesis can lead to complications like electrolyte disorders, dehydration, metabolic disturbances and nutrition problems with weight loss. Prophylactic antiemetics are often given to patients receiving single high-dose radiotherapy to the abdomen. A survey has revealed that antiemetic prophylaxis is not routinely offered to the patients receiving fractionated radiotherapy. However, there is a need for an effective treatment of emesis for use in this group of patients, too. In 20% of patients nausea and emesis can cause a treatment interruption because of an inadequate control of symptoms. Like in chemotherapy strategies there exist high, moderate, and low emetogenic treatment regimens in radiotherapy as well. The most emetogenic potential has the total body irradiation followed by radiotherapy to the abdomen. Radiotherapy induced emesis can be treated effectively with conventional antiemetics up to 50%. Conclusions: Studies with total body irradiation, fractionated treatment and high-dose single exposures have cleary demonstrated the value of 5-HT3-receptor antagonist antiemetics. There is a response between 60 and 97%. There is no difference in the efficacy of the different 5-HT3-antagonists. High-risk patients should be prophylactic

  10. Neurokinin-1 receptor antagonists for chemotherapy-induced nausea and vomiting. (United States)

    Aziz, Fahad


    Chemotherapy can be a life-prolonging treatment for many cancer patients, but it is often associated with profound nausea and vomiting that is so distressing that patients may delay or decline treatment to avoid these side effects. The discovery of several NK1 receptor antagonists is a big revolution to dealt this problem. NK1 receptor antagonists prevent both acute and delayed chemotherapy-induced nausea and vomiting (CINV). These agents act centrally at NK-1 receptors in vomiting centers within the central nervous system to block their activation by substance P released as an unwanted consequence of chemotherapy. By controlling nausea and vomiting, these agents help improve patients' daily living and their ability to complete multiple cycles of chemotherapy. They are effective for both moderately and highly emetogenic chemotherapy regimens. Their use might be associated with increased infection rates; however, additional appraisal of specific data from RCTs is needed.

  11. Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting (United States)

    Navari, Rudolph M.; Qin, Rui; Ruddy, Kathryn J.; Liu, Heshan; Powell, Steven F.; Bajaj, Madhuri; Dietrich, Leah; Biggs, David; Lafky, Jacqueline M.; Loprinzi, Charles L.


    BACKGROUND We examined the efficacy of olanzapine for the prevention of nausea and vomiting in patients receiving highly emetogenic chemotherapy. METHODS In a randomized, double-blind, phase 3 trial, we compared olanzapine with placebo, in combination with dexamethasone, aprepitant or fosaprepitant, and a 5-hydroxytryptamine type 3–receptor antagonist, in patients with no previous chemotherapy who were receiving cisplatin (≥70 mg per square meter of body-surface area) or cyclophosphamide–doxorubicin. The doses of the three concomitant drugs administered before and after chemotherapy were similar in the two groups. The two groups received either 10 mg of olanzapine orally or matching placebo daily on days 1 through 4. Nausea prevention was the primary end point; a complete response (no emesis and no use of rescue medication) was a secondary end point. RESULTS In the analysis, we included 380 patients who could be evaluated (192 assigned to olanzapine, and 188 to placebo). The proportion of patients with no chemotherapy-induced nausea was significantly greater with olanzapine than with placebo in the first 24 hours after chemotherapy (74% vs. 45%, P = 0.002), the period from 25 to 120 hours after chemotherapy (42% vs. 25%, P = 0.002), and the overall 120-hour period (37% vs. 22%, P = 0.002). The complete-response rate was also significantly increased with olanzapine during the three periods: 86% versus 65% (P<0.001), 67% versus 52% (P = 0.007), and 64% versus 41% (P<0.001), respectively. Although there were no grade 5 toxic effects, some patients receiving olanzapine had increased sedation (severe in 5%) on day 2. CONCLUSIONS Olanzapine, as compared with placebo, significantly improved nausea prevention, as well as the complete-response rate, among previously untreated patients who were receiving highly emetogenic chemotherapy. (Funded by the National Cancer Institute; number, NCT02116530.) PMID:27410922

  12. High blood pressure medications (United States)

    ... this page: // High blood pressure medicines To use the sharing features on this page, please enable JavaScript. Treating high blood pressure will help prevent problems such as heart disease, ...

  13. High-Risk Pregnancy (United States)

    ... NICHD Research Information Clinical Trials Resources and Publications High-Risk Pregnancy: Condition Information Skip sharing on social media links Share this: Page Content A high-risk pregnancy refers to anything that puts the ...

  14. High blood cholesterol levels (United States)

    ... this page: // High blood cholesterol levels To use the sharing features ... stroke, and other problems. The medical term for high blood cholesterol is lipid disorder, hyperlipidemia, or hypercholesterolemia. ...

  15. Treating High Blood Pressure (United States)

    About High Blood Pressure Many people in the United States die from high blood pressure. This condition usually does not cause symptoms. Most ... until it is too late. A person has high blood pressure when the blood pushes against Visit your doctor ...

  16. High performance systems

    Energy Technology Data Exchange (ETDEWEB)

    Vigil, M.B. [comp.


    This document provides a written compilation of the presentations and viewgraphs from the 1994 Conference on High Speed Computing given at the High Speed Computing Conference, {open_quotes}High Performance Systems,{close_quotes} held at Gleneden Beach, Oregon, on April 18 through 21, 1994.

  17. High-temperature superconductors

    CERN Document Server

    Saxena, Ajay Kumar


    The present book aims at describing the phenomenon of superconductivity and high-temperature superconductors discovered by Bednorz and Muller in 1986. The book covers the superconductivity phenomenon, structure of high-Tc superconductors, critical currents, synthesis routes for high Tc materials, superconductivity in cuprates, the proximity effect and SQUIDs, theories of superconductivity and applications of superconductors.

  18. Highly Ionized Envelopes of High Velocity Clouds

    CERN Document Server

    Zekis, Erin E


    We present recent results on highly ionized gas in Galactic High-Velocity Clouds (HVCs), originally surveyed in OVI (Sembach et al. 2003). In a new FUSE/HST survey of SiII/III/IV (Shull et al. 2009) toward 37 AGN, we detected SiIII (lambda 1206.500 A) absorption with a sky coverage fraction 81 +/- 5% (61 HVCs along 30 of 37 high-latitude sight lines). The SiIII (lambda 1206.500 A) line is typically 4-5 times stronger than OVI (lambda 1031.926 A). The mean HVC column density of perhaps 10^19 cm^-2 of low-metallicity (0.1 - 0.2 Z_sun) ionized gas in the low halo. Recent determinations of HVC distances allow us to estimate a total reservoir of ~10^8 M_sun. Estimates of infall velocities indicate an infall rate of around 1 M_sun yr^-1, comparable to the replenishment rate for star formation in the disk. HVCs appear to be sheathed by intermediate-temperature gas (10^4.0 - 10^4.5 K) detectable in SiIII and SiIV, as well as hotter gas seen in OVI and other high ions. To prepare for HST observations of 10 HVC-selecte...

  19. High power, high beam quality regenerative amplifier (United States)

    Hackel, L.A.; Dane, C.B.


    A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

  20. High Sensitivity, High Frequency and High Time Resolution Decimetric Spectroscope (United States)

    Sawant, H. S.; Rosa, R. R.


    RESUMEN. Se ha desarrollado el primer espectroscopio decimetrico latino americano operando en una banda de 100 MHz con alta resoluci6n de fre- cuencia (100 KHz) y tiempo (10 ms), alrededor de cualquier centro de frecuencia en el intervalo de 2000-200 MHz. El prop6sito de esta nota es describir investigaciones solares y no solares que se planean, progra ma de investigaci6n y la situaci6n actual de desarrollo de este espectroscopio. ABSTRACT. First Latin American Decimetric Spectroscope operating over a band of 100 MHz with high resolution in frequency (100 KHz) and time (10 ms), around any center frequency in the range of 2000-200 MHz is being developed. The purpose of this note is to describe planned solar, and non-solar, research programmes and present status of development of this spectroscope. Keq wo : INSTRUMENTS - SPECTROSCOPY

  1. High Precision Measurements Using High Frequency Signals

    CERN Document Server

    Jin, Aohan; Sakurai, Atsunori; Liu, Liang; Edman, Fredrik; Öwall, Viktor; Pullerits, Tonu; Karki, Khadga J


    Generalized lock-in amplifiers use digital cavities with Q-factors as high as 5X10^8. In this letter, we show that generalized lock-in amplifiers can be used to analyze microwave (giga-hertz) signals with a precision of few tens of hertz. We propose that the physical changes in the medium of propagation can be measured precisely by the ultra-high precision measurement of the signal. We provide evidence to our proposition by verifying the Newton's law of cooling by measuring the effect of change in temperature on the phase and amplitude of the signals propagating through two calibrated cables. The technique could be used to precisely measure different physical properties of the propagation medium, for example length, resistance, etc. Real time implementation of the technique can open up new methodologies of in-situ virtual metrology in material design.

  2. Photoproduction at High Energy and High Intensity

    CERN Multimedia


    The photon beam used for this programme is tagged and provides a large flux up to very high energies (150-200 GeV). It is also hadron-free, since it is obtained by a two-step conversion method. A spectrometer is designed to exploit this beam and to perform a programme of photoproduction with a high level of sensitivity (5-50 events/picobarn).\\\\ \\\\ Priority will be given to the study of processes exhibiting the point-like behaviour of the photon, especially deep inelastic Compton scattering. The spectrometer has two magnets. Charged tracks are measured by MWPC's located only in field-free regions. Three calorimeters provide a large coverage for identifying and measuring electrons and photons. An iron filter downstream identifies muons. Most of the equipment is existing and recuperated from previous experiments.

  3. Space Based Infrared System High (SBIRS High) (United States)


    Aviation Blvd Bldg 271 Los Angeles Air Force Base (LAAFB) El Segundo, CA 90245-2808 Phone: 310-653-3018 Fax: 310-653-4414 DSN...mission areas: Missile Warning , Missile Defense, Technical Intelligence and Battlespace Awareness. The constellation architecture for SBIRS High...Integrated Tactical Warning /Attack Assessment (ITW/AA) mission in November 2008 and technical intelligence mission in August 2009. The SBIRS GEO 1

  4. Technological Aspects: High Voltage

    CERN Document Server

    Faircloth, D C


    This paper covers the theory and technological aspects of high-voltage design for ion sources. Electric field strengths are critical to understanding high-voltage breakdown. The equations governing electric fields and the techniques to solve them are discussed. The fundamental physics of high-voltage breakdown and electrical discharges are outlined. Different types of electrical discharges are catalogued and their behaviour in environments ranging from air to vacuum are detailed. The importance of surfaces is discussed. The principles of designing electrodes and insulators are introduced. The use of high-voltage platforms and their relation to system design are discussed. The use of commercially available high-voltage technology such as connectors, feedthroughs and cables are considered. Different power supply technologies and their procurement are briefly outlined. High-voltage safety, electric shocks and system design rules are covered.

  5. High-Temperature Superconductivity (United States)

    Tanaka, Shoji


    A general review on high-temperature superconductivity was made. After prehistoric view and the process of discovery were stated, the special features of high-temperature superconductors were explained from the materials side and the physical properties side. The present status on applications of high-temperature superconductors were explained on superconducting tapes, electric power cables, magnets for maglev trains, electric motors, superconducting quantum interference device (SQUID) and single flux quantum (SFQ) devices and circuits.

  6. High performance homes

    DEFF Research Database (Denmark)

    Beim, Anne; Vibæk, Kasper Sánchez


    Can prefabrication contribute to the development of high performance homes? To answer this question, this chapter defines high performance in more broadly inclusive terms, acknowledging the technical, architectural, social and economic conditions under which energy consumption and production occur....... Consideration of all these factors is a precondition for a truly integrated practice and as this chapter demonstrates, innovative project delivery methods founded on the manufacturing of prefabricated buildings contribute to the production of high performance homes that are cost effective to construct, energy...

  7. High enthalpy gas dynamics

    CERN Document Server

    Rathakrishnan, Ethirajan


    This is an introductory level textbook which explains the elements of high temperature and high-speed gas dynamics. written in a clear and easy to follow style, the author covers all the latest developments in the field including basic thermodynamic principles, compressible flow regimes and waves propagation in one volume covers theoretical modeling of High Enthalpy Flows, with particular focus on problems in internal and external gas-dynamic flows, of interest in the fields of rockets propulsion and hypersonic aerodynamics High enthalpy gas dynamics is a compulsory course for aerospace engine

  8. High voltage engineering

    CERN Document Server

    Rizk, Farouk AM


    Inspired by a new revival of worldwide interest in extra-high-voltage (EHV) and ultra-high-voltage (UHV) transmission, High Voltage Engineering merges the latest research with the extensive experience of the best in the field to deliver a comprehensive treatment of electrical insulation systems for the next generation of utility engineers and electric power professionals. The book offers extensive coverage of the physical basis of high-voltage engineering, from insulation stress and strength to lightning attachment and protection and beyond. Presenting information critical to the design, selec

  9. Proxmox high availability

    CERN Document Server

    Cheng, Simon MC


    If you want to know the secrets of virtualization and how to implement high availability on your services, this is the book for you. For those of you who are already using Proxmox, this book offers you the chance to build a high availability cluster with a distributed filesystem to further protect your system from failure.

  10. High coking value pitch

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Douglas J.; Chang, Ching-Feng; Lewis, Irwin C.; Lewis, Richard T.


    A high coking value pitch prepared from coal tar distillate and has a low softening point and a high carbon value while containing substantially no quinoline insolubles is disclosed. The pitch can be used as an impregnant or binder for producing carbon and graphite articles.

  11. High-pressure apparatus

    NARCIS (Netherlands)

    Schepdael, van L.J.M.; Bartels, P.V.; Berg, van den R.W.


    The invention relates to a high-pressure device (1) having a cylindrical high-pressure vessel (3) and prestressing means in order to exert an axial pressure on the vessel. The vessel (3) can have been formed from a number of layers of composite material, such as glass, carbon or aramide fibers which

  12. Highly interactive distributed visualization

    NARCIS (Netherlands)

    Scarpa, M.; Belleman, R.G.; Sloot, P.M.A.; de Laat, C.T.A.M.


    We report on our iGrid2005 demonstration, called the "Dead Cat Demo"; an example of a highly interactive augmented reality application consisting of software services distributed over a wide-area, high-speed network. We describe our design decisions, analyse the implications of the design on applica

  13. High assurance services computing

    CERN Document Server


    Covers service-oriented technologies in different domains including high assurance systemsAssists software engineers from industry and government laboratories who develop mission-critical software, and simultaneously provides academia with a practitioner's outlook on the problems of high-assurance software development

  14. High Nitrogen Stainless Steel (United States)


    Kiev, 1993. 7. High Nitrogen Steels, edited by M. Kikuchi and Y. Mishima , Vol. 36, No. 7, Iron and Steel Institute of Japan Inernational, Tokyo...the Corrosion of Iron and Steels,” High Nitrogen Steels, edited by M. Kikuchi and Y. Mishima , Vol. 36, No. 7, Iron and Steel Institute of Japan

  15. High density photovoltaic

    Energy Technology Data Exchange (ETDEWEB)

    Haigh, R.E.; Jacobson, G.F.; Wojtczuk, S. [Spire Corp., Bedford, MA (United States)


    Photovoltaic technology can directly generate high voltages in a solid state material through the series interconnect of many photovoltaic diodes. We are investigating the feasibility of developing an electrically isolated, high-voltage power supply using miniature photovoltaic devices that convert optical energy to electrical energy.

  16. Phononic High Harmonic Generation

    CERN Document Server

    Ganesan, Adarsh; Seshia, Ashwin A


    This paper reports the first experimental evidence for phononic low-order to high-order harmonic conversion leading to high harmonic generation. Similar to parametric resonance, phononic high harmonic generation is also mediated by a threshold dependent instability of a driven phonon mode. Once the threshold for instability is met, a cascade of harmonic generation processes is triggered. Firstly, the up-conversion of first harmonic phonons into second harmonic phonons is established. Subsequently, the down-conversion of second harmonic phonons into first harmonic phonons and conversion of first and second harmonic phonons into third harmonic phonons occur. On the similar lines, an eventual conversion of third harmonic phonons to high orders is also observed to commence. This surprising physical pathway for phononic low-order to high-order harmonic conversion may find general relevance to other physical systems.

  17. High Performance Marine Vessels

    CERN Document Server

    Yun, Liang


    High Performance Marine Vessels (HPMVs) range from the Fast Ferries to the latest high speed Navy Craft, including competition power boats and hydroplanes, hydrofoils, hovercraft, catamarans and other multi-hull craft. High Performance Marine Vessels covers the main concepts of HPMVs and discusses historical background, design features, services that have been successful and not so successful, and some sample data of the range of HPMVs to date. Included is a comparison of all HPMVs craft and the differences between them and descriptions of performance (hydrodynamics and aerodynamics). Readers will find a comprehensive overview of the design, development and building of HPMVs. In summary, this book: Focuses on technology at the aero-marine interface Covers the full range of high performance marine vessel concepts Explains the historical development of various HPMVs Discusses ferries, racing and pleasure craft, as well as utility and military missions High Performance Marine Vessels is an ideal book for student...

  18. High performance germanium MOSFETs

    Energy Technology Data Exchange (ETDEWEB)

    Saraswat, Krishna [Department of Electrical Engineering, Stanford University, Stanford, CA 94305 (United States)]. E-mail:; Chui, Chi On [Department of Electrical Engineering, Stanford University, Stanford, CA 94305 (United States); Krishnamohan, Tejas [Department of Electrical Engineering, Stanford University, Stanford, CA 94305 (United States); Kim, Donghyun [Department of Electrical Engineering, Stanford University, Stanford, CA 94305 (United States); Nayfeh, Ammar [Department of Electrical Engineering, Stanford University, Stanford, CA 94305 (United States); Pethe, Abhijit [Department of Electrical Engineering, Stanford University, Stanford, CA 94305 (United States)


    Ge is a very promising material as future channel materials for nanoscale MOSFETs due to its high mobility and thus a higher source injection velocity, which translates into higher drive current and smaller gate delay. However, for Ge to become main-stream, surface passivation and heterogeneous integration of crystalline Ge layers on Si must be achieved. We have demonstrated growth of fully relaxed smooth single crystal Ge layers on Si using a novel multi-step growth and hydrogen anneal process without any graded buffer SiGe layer. Surface passivation of Ge has been achieved with its native oxynitride (GeO {sub x}N {sub y} ) and high-permittivity (high-k) metal oxides of Al, Zr and Hf. High mobility MOSFETs have been demonstrated in bulk Ge with high-k gate dielectrics and metal gates. However, due to their smaller bandgap and higher dielectric constant, most high mobility materials suffer from large band-to-band tunneling (BTBT) leakage currents and worse short channel effects. We present novel, Si and Ge based heterostructure MOSFETs, which can significantly reduce the BTBT leakage currents while retaining high channel mobility, making them suitable for scaling into the sub-15 nm regime. Through full band Monte-Carlo, Poisson-Schrodinger and detailed BTBT simulations we show a dramatic reduction in BTBT and excellent electrostatic control of the channel, while maintaining very high drive currents in these highly scaled heterostructure DGFETs. Heterostructure MOSFETs with varying strained-Ge or SiGe thickness, Si cap thickness and Ge percentage were fabricated on bulk Si and SOI substrates. The ultra-thin ({approx}2 nm) strained-Ge channel heterostructure MOSFETs exhibited >4x mobility enhancements over bulk Si devices and >10x BTBT reduction over surface channel strained SiGe devices.

  19. Drug: D00677 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Antiemetics Emetogenic Therapy Adjuncts Granisetron D00677 Granisetron hydrochloride (JAN/USAN) Target-base...gonists A04AA02 Granisetron D00677 Granisetron hydrochloride (JAN/USAN) USP drug classification [BR:br08302

  20. Drug: D00456 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Antiemetics Emetogenic Therapy Adjuncts Ondansetron D00456 Ondansetron (JAN/USP/...(5HT3) antagonists A04AA01 Ondansetron D00456 Ondansetron (JAN/USP/INN) USP drug classification [BR:br08302

  1. High Antibiotic Consumption

    DEFF Research Database (Denmark)

    Malo, Sara; José Rabanaque, María; Feja, Cristina;


    with highest consumption) were responsible for 21% of the total DDD consumed and received ≥6 packages per year. Elderly adults (≥60 years) and small children (0-9 years) were those exposed to the highest volume of antibiotics and with the most frequent exposure, respectively. Heavy users received a high...... proportion of antibiotics not recommended as first choice in primary health care. In conclusion, heavy antibiotic users consisted mainly of children and old adults. Inappropriate overuse of antibiotics (high quantity, high frequency, and inappropriate antibiotic choice) leads to a substantial risk...

  2. High voltage test techniques

    CERN Document Server

    Kind, Dieter


    The second edition of High Voltage Test Techniques has been completely revised. The present revision takes into account the latest international developments in High Voltage and Measurement technology, making it an essential reference for engineers in the testing field.High Voltage Technology belongs to the traditional area of Electrical Engineering. However, this is not to say that the area has stood still. New insulating materials, computing methods and voltage levels repeatedly pose new problems or open up methods of solution; electromagnetic compatibility (EMC) or components and systems al

  3. High Efficiency, High Performance Clothes Dryer

    Energy Technology Data Exchange (ETDEWEB)

    Peter Pescatore; Phil Carbone


    This program covered the development of two separate products; an electric heat pump clothes dryer and a modulating gas dryer. These development efforts were independent of one another and are presented in this report in two separate volumes. Volume 1 details the Heat Pump Dryer Development while Volume 2 details the Modulating Gas Dryer Development. In both product development efforts, the intent was to develop high efficiency, high performance designs that would be attractive to US consumers. Working with Whirlpool Corporation as our commercial partner, TIAX applied this approach of satisfying consumer needs throughout the Product Development Process for both dryer designs. Heat pump clothes dryers have been in existence for years, especially in Europe, but have not been able to penetrate the market. This has been especially true in the US market where no volume production heat pump dryers are available. The issue has typically been around two key areas: cost and performance. Cost is a given in that a heat pump clothes dryer has numerous additional components associated with it. While heat pump dryers have been able to achieve significant energy savings compared to standard electric resistance dryers (over 50% in some cases), designs to date have been hampered by excessively long dry times, a major market driver in the US. The development work done on the heat pump dryer over the course of this program led to a demonstration dryer that delivered the following performance characteristics: (1) 40-50% energy savings on large loads with 35 F lower fabric temperatures and similar dry times; (2) 10-30 F reduction in fabric temperature for delicate loads with up to 50% energy savings and 30-40% time savings; (3) Improved fabric temperature uniformity; and (4) Robust performance across a range of vent restrictions. For the gas dryer development, the concept developed was one of modulating the gas flow to the dryer throughout the dry cycle. Through heat modulation in a

  4. Landforms of High Mountains

    Directory of Open Access Journals (Sweden)

    Derek A. McDougall


    Full Text Available Reviewed: Landforms of High Mountains. By Alexander Stahr and Ewald Langenscheidt. Heidelberg, Germany: Springer, 2015. viii + 158 pp. US$ 129.99. Also available as an e-book. ISBN 978-3-642-53714-1.

  5. High-Tech Architecture

    Directory of Open Access Journals (Sweden)

    Özlem Eşsiz


    Full Text Available The technological development in building and construction area, bring with the new construction systems and the new products. The aim of this study is to define the High Tech concept, and set the common and basic characteristics of High Tech applications. During 1970’s High Tech was born and developed in Britain. Especially British Architects Richard Rogers, Michael Hopkins, Norman Foster, Nicholas Grimshaw and Ian Ritchie are the leaders of this style. Their architecture show the machine aesthetic and use of industrial revoluation materials such as glass and steel. The reasons for wide usage of this technology in building constructions are; the ease of renewing the structural and installation systems by the changing technology and giving monumentality to the prestige buildings. High Tech building which we have many examples of give their occupants a lot of opportunities and also they can adapt itself to the time.

  6. High temperature battery. Hochtemperaturbatterie

    Energy Technology Data Exchange (ETDEWEB)

    Bulling, M.


    To prevent heat losses of a high temperature battery, it is proposed to make the incoming current leads in the area of their penetration through the double-walled insulating housing as thermal throttle, particularly spiral ones.

  7. High Blood Pressure (United States)

    ... may have tax advantages for you. Workplace giving Workplace giving Find a list of the most common ... pressure and cholesterol. Exercise can also help relieve stress, another common cause of high blood pressure. To ...

  8. Responsive design high performance

    CERN Document Server

    Els, Dewald


    This book is ideal for developers who have experience in developing websites or possess minor knowledge of how responsive websites work. No experience of high-level website development or performance tweaking is required.

  9. High Plains Aquifer (United States)

    Kansas Data Access and Support Center — These digital maps contain information on the altitude of the base, the extent, and the 1991 potentiometric surface (i.e. altitude of the water table) of the High...

  10. High Blood Pressure (Hypertension) (United States)

    ... already been diagnosed with high blood pressure. Try yoga and meditation. Yoga and meditation not only can strengthen your body ... Accessed Sept. 21, 2015. Hu B, et al. Effects of psychological stress on hypertension in middle-aged ...

  11. Hyperglycemia (High Blood Glucose)

    Medline Plus

    Full Text Available ... Blood Pressure Physical Activity High Blood Glucose My Health Advisor Tools To Know Your Risk Alert Day ... DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose Testing ...

  12. Hyperglycemia (High Blood Glucose)

    Medline Plus

    Full Text Available ... to Give Close Are You at Risk? Home Prevention Diagnosing Diabetes and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High Blood Pressure Physical Activity ...

  13. Hyperglycemia (High Blood Glucose)

    Medline Plus

    Full Text Available ... and Learning About Prediabetes Type 2 Diabetes Risk Test Lower Your Risk Healthy Eating Overweight Smoking High ... You at Risk? Diagnosis Lower Your Risk Risk Test Alert Day Prediabetes My Health Advisor Tools to ...

  14. High Resolution Elevation Contours (United States)

    Minnesota Department of Natural Resources — This dataset contains contours generated from high resolution data sources such as LiDAR. Generally speaking this data is 2 foot or less contour interval.

  15. Microwave Radiometer - high frequency (United States)

    Oak Ridge National Laboratory — The Microwave Radiometer-High Frequency (MWRHF) provides time-series measurements of brightness temperatures from two channels centered at 90 and 150 GHz. These two...


    Directory of Open Access Journals (Sweden)

    Dwitya Elvira


    Full Text Available AbstrakHigh-altitude illness (HAI merupakan sekumpulan gejala paru dan otak yang terjadi pada orang yang baru pertama kali mendaki ke ketinggian. HAI terdiri dari acute mountain sickness (AMS, high-altitude cerebral edema (HACE dan high-altitude pulmonary edema (HAPE. Tujuan tinjauan pustaka ini adalah agar dokter dan wisatawan memahami risiko, tanda, gejala, dan pengobatan high-altitude illness. Perhatian banyak diberikan terhadap penyakit ini seiring dengan meningkatnya popularitas olahraga ekstrim (mendaki gunung tinggi, ski dan snowboarding dan adanya kemudahan serta ketersediaan perjalanan sehingga jutaan orang dapat terpapar bahaya HAI. Di Pherice, Nepal (ketinggian 4343 m, 43% pendaki mengalami gejala AMS. Pada studi yang dilakukan pada tempat wisata di resort ski Colorado, Honigman menggambarkan kejadian AMS 22% pada ketinggian 1850 m sampai 2750 m, sementara Dean menunjukkan 42% memiliki gejala pada ketinggian 3000 m. Aklimatisasi merupakan salah satu tindakan pencegahan yang dapat dilakukan sebelum pendakian, selain beberapa pengobatan seperti asetazolamid, dexamethasone, phosopodiestrase inhibitor, dan ginko biloba.Kata kunci: high-altitude illness, acute mountain sickness, edema cerebral, pulmonary edema AbstractHigh-altitude illness (HAI is symptoms of lung and brain that occurs in people who first climb to altitude. HAI includes acute mountain sickness (AMS, high-altitude cerebral edema (HACE and high altitude pulmonary edema (HAPE. The objective of this review was to understand the risks, signs, symptoms, and treatment of high-altitude illness. The attention was given to this disease due to the rising popularity of extreme sports (high mountain climbing, skiing and snowboarding and the ease and availability of the current travelling, almost each year, millions of people could be exposed to the danger of HAI. In Pherice, Nepal (altitude 4343 m, 43% of climbers have symptoms of AMS. Furthermore, in a study conducted at sites in

  17. High power fiber lasers

    Institute of Scientific and Technical Information of China (English)

    LOU Qi-hong; ZHOU Jun


    In this review article, the development of the double cladding optical fiber for high power fiber lasers is reviewed. The main technology for high power fiber lasers, including laser diode beam shaping, fiber laser pumping techniques, and amplification systems, are discussed in de-tail. 1050 W CW output and 133 W pulsed output are ob-tained in Shanghai Institute of Optics and Fine Mechanics, China. Finally, the applications of fiber lasers in industry are also reviewed.

  18. High energy astrophysical neutrinos


    Athar, H.


    High energy neutrinos with energy typically greater than tens of thousands of GeV may originate from several astrophysical sources. The sources may include, for instance, our galaxy, the active centers of nearby galaxies, as well as possibly the distant sites of gamma ray bursts. I briefly review some aspects of production and propagation as well as prospects for observations of these high energy astrophysical neutrinos.

  19. High Performance Concrete


    Traian Oneţ


    The paper presents the last studies and researches accomplished in Cluj-Napoca related to high performance concrete, high strength concrete and self compacting concrete. The purpose of this paper is to raid upon the advantages and inconveniences when a particular concrete type is used. Two concrete recipes are presented, namely for the concrete used in rigid pavement for roads and another one for self-compacting concrete.

  20. High efficiency incandescent lighting (United States)

    Bermel, Peter; Ilic, Ognjen; Chan, Walker R.; Musabeyoglu, Ahmet; Cukierman, Aviv Ruben; Harradon, Michael Robert; Celanovic, Ivan; Soljacic, Marin


    Incandescent lighting structure. The structure includes a thermal emitter that can, but does not have to, include a first photonic crystal on its surface to tailor thermal emission coupled to, in a high-view-factor geometry, a second photonic filter selected to reflect infrared radiation back to the emitter while passing visible light. This structure is highly efficient as compared to standard incandescent light bulbs.

  1. High voltage engineering fundamentals

    CERN Document Server

    Kuffel, E; Hammond, P


    Provides a comprehensive treatment of high voltage engineering fundamentals at the introductory and intermediate levels. It covers: techniques used for generation and measurement of high direct, alternating and surge voltages for general application in industrial testing and selected special examples found in basic research; analytical and numerical calculation of electrostatic fields in simple practical insulation system; basic ionisation and decay processes in gases and breakdown mechanisms of gaseous, liquid and solid dielectrics; partial discharges and modern discharge detectors; and over

  2. Adaptation to High Altitude



    Hypoxia is inconsequential for physiologically fit persons below an effective altitude of 2640 metres. At higher altitudes, the adaptation is brought about by four main factors, viz., hyperventilation, increased diffusion of oxygen across alveolar membrane, erythrocythemia and maintenance of body hydration. Carbon dioxide sensitivity is markedly elevated at high altitude, both in sojourners and acclimatized low-landers. The greater pulmonary diffusing capacity observed in high altitude native...

  3. High throughput drug profiling


    Entzeroth, Michael; Chapelain, Béatrice; Guilbert, Jacques; Hamon, Valérie


    High throughput screening has significantly contributed to advances in drug discovery. The great increase in the number of samples screened has been accompanied by increases in costs and in the data required for the investigated compounds. High throughput profiling addresses the issues of compound selectivity and specificity. It combines conventional screening with data mining technologies to give a full set of data, enabling development candidates to be more fully compared.

  4. High surface area, high permeability carbon monoliths

    Energy Technology Data Exchange (ETDEWEB)

    Lagasse, R.R.; Schroeder, J.L. [Sandia National Labs., Albuquerque, NM (United States). Organic Materials Processing Dept.


    The goal of this work is to prepare carbon monoliths having precisely tailored pore size distribution. Prior studies have demonstrated that poly(acrylonitrile) can be processed into a precursor having tailored macropore structure. Since the macropores were preserved during pyrolysis, this synthetic process provided a route to porous carbon having macropores with size =0.1 to 10{mu}m. No micropores of size <2 nm could be detected in the carbon, however, by nitrogen adsorption. In the present work, the authors have processed a different polymer, poly(vinylidene chloride) into a macroporous precursor, Pyrolysis produced carbon monoliths having macropores derived from the polymer precursor as well as extensive microporosity produced during the pyrolysis of the polymer. One of these carbons had BET surface area of 1,050 m{sup 2}/g and about 1.2 cc/g total pore volume, with about 1/3 of the total pore volume in micropores and the remainder in 1{mu}m macropores. No mesopores in the intermediate size range could be detected by nitrogen adsorption. Carbon materials having high surface area as well as micron size pores have potential applications as electrodes for double layer supercapacitors containing liquid electrolyte, or as efficient media for performing chemical separations.

  5. High-density lipoprotein cholesterol: How High

    Directory of Open Access Journals (Sweden)

    G Rajagopal


    Full Text Available The high-density lipoprotein cholesterol (HDL-C is considered anti-atherogenic good cholesterol. It is involved in reverse transport of lipids. Epidemiological studies have found inverse relationship of HDL-C and coronary heart disease (CHD risk. When grouped according to HDL-C, subjects having HDL-C more than 60 mg/dL had lesser risk of CHD than those having HDL-C of 40-60 mg/dL, who in turn had lesser risk than those who had HDL-C less than 40 mg/dL. No upper limit for beneficial effect of HDL-C on CHD risk has been identified. The goals of treating patients with low HDL-C have not been firmly established. Though many drugs are known to improve HDL-C concentration, statins are proven to improve CHD risk and mortality. Cholesteryl ester transfer protein (CETP is involved in metabolism of HDL-C and its inhibitors are actively being screened for clinical utility. However, final answer is still awaited on CETP-inhibitors.

  6. High Gradient Accelerator Research

    Energy Technology Data Exchange (ETDEWEB)

    Temkin, Richard [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Physics. Plasma Science and Fusion Center


    The goal of the MIT program of research on high gradient acceleration is the development of advanced acceleration concepts that lead to a practical and affordable next generation linear collider at the TeV energy level. Other applications, which are more near-term, include accelerators for materials processing; medicine; defense; mining; security; and inspection. The specific goals of the MIT program are: • Pioneering theoretical research on advanced structures for high gradient acceleration, including photonic structures and metamaterial structures; evaluation of the wakefields in these advanced structures • Experimental research to demonstrate the properties of advanced structures both in low-power microwave cold test and high-power, high-gradient test at megawatt power levels • Experimental research on microwave breakdown at high gradient including studies of breakdown phenomena induced by RF electric fields and RF magnetic fields; development of new diagnostics of the breakdown process • Theoretical research on the physics and engineering features of RF vacuum breakdown • Maintaining and improving the Haimson / MIT 17 GHz accelerator, the highest frequency operational accelerator in the world, a unique facility for accelerator research • Providing the Haimson / MIT 17 GHz accelerator facility as a facility for outside users • Active participation in the US DOE program of High Gradient Collaboration, including joint work with SLAC and with Los Alamos National Laboratory; participation of MIT students in research at the national laboratories • Training the next generation of Ph. D. students in the field of accelerator physics.

  7. Kilburn High Road Revisited

    Directory of Open Access Journals (Sweden)

    Cristina Capineri


    Full Text Available Drawing on John Agnew’s (1987 theoretical framework for the analysis of place (location, locale and sense of place and on Doreen Massey’s (1991 interpretation of Kilburn High Road (London, the contribution develops an analysis of the notion of place in the case study of Kilburn High Road by comparing the semantics emerging from Doreen Massey’s interpretation of Kilburn High Road in the late Nineties with those from a selection of noisy and unstructured volunteered geographic information collected from Flickr photos and Tweets harvested in 2014–2015. The comparison shows how sense of place is dynamic and changing over time and explores Kilburn High Road through the categories of location, locale and sense of place derived from the qualitative analysis of VGI content and annotations. The contribution shows how VGI can contribute to discovering the unique relationship between people and place which takes the form given by Doreen Massey to Kilburn High Road and then moves on to the many forms given by people experiencing Kilburn High Road through a photo, a Tweet or a simple narrative. Finally, the paper suggests that the analysis of VGI content can contribute to detect the relevant features of street life, from infrastructure to citizens’ perceptions, which should be taken into account for a more human-centered approach in planning or service management.

  8. Adaptation to High Altitude

    Directory of Open Access Journals (Sweden)

    H. S. Nayar


    Full Text Available Hypoxia is inconsequential for physiologically fit persons below an effective altitude of 2640 metres. At higher altitudes, the adaptation is brought about by four main factors, viz., hyperventilation, increased diffusion of oxygen across alveolar membrane, erythrocythemia and maintenance of body hydration. Carbon dioxide sensitivity is markedly elevated at high altitude, both in sojourners and acclimatized low-landers. The greater pulmonary diffusing capacity observed in high altitude natives is well documented. RBC count, haemoglobin and haematocrit increase whereas arterial oxyhaemoglobin saturation percentage decreases at high altitude. Diuretics (Furosemide have no role in adaptation to high altitude and adequate body hydration must be maintained.The ultimate adaptive mechanisms occur at tissue level which facilitate the diffusion of oxygen from blood to tissue and its utilization. The work capacity decreases at high altitude and a relationship between load carried and speed of marching has been determined at various altitudes. Although altitude has an adverse effect on process of cold acclimatization, yet it is possible to induce cold acclimatization by exposing subjects to a temperature of 0° to -5°C for a period of three hours daily for three weeks. The caloric requirements increase at high altitudes and are 4,286 K Cal and 4,380 K Cal at 13000 feet (3950 m and 17000 feet (5170 m, respectively.

  9. High Caloric Diet for ALS Patients: High Fat, High Carbohydrate or High Protein

    Directory of Open Access Journals (Sweden)

    Sarvin Sanaie


    Full Text Available ALS is a fatal motor neurodegenerative disease characterized by muscle atrophy and weakness, dysarthria, and dysphagia. The mean survival of ALS patients is three to five years, with 50% of those diagnosed dying within three years of onset (1. A multidisciplinary approach is crucial to set an appropriate plan for metabolic and nutritional support in ALS. Nutritional management incorporates a continuous assessment and implementation of dietary modifications throughout the duration of the disease. The nutritional and metabolic approaches to ALS should start when the diagnosis of ALS is made and should become an integral part of the continuous care to the patient, including nutritional surveillance, dietary counseling, management of dysphagia, and enteral nutrition when needed. Malnutrition and lean body mass loss are frequent findings in ALS patients necessitating comprehensive energy requirement assessment for these patients. Malnutrition is an independent prognostic factor for survival in ALS with a 7.7 fold increase in risk of death. Malnutrition is estimated to develop in one quarter to half of people with ALS (2. Adequate calorie and protein provision would diminish muscle loss in this vulnerable group of patients. Although appropriate amount of energy to be administered is yet to be established, high calorie diet is expected to be effective for potential improvement of survival; ALS patients do not normally receive adequate  intake of energy. A growing number of clinicians suspect that a high calorie diet implemented early in their disease may help people with ALS meet their increased energy needs and extend their survival. Certain high calorie supplements appear to be safe and well tolerated by people with ALS according to studies led by Universitäts klinikum Ulm's and, appear to stabilize body weight within 3 months. In a recent study by Wills et al., intake of high-carbohydrate low-fat supplements has been recommended in ALS patients (3

  10. High Temperature Capacitor Development

    Energy Technology Data Exchange (ETDEWEB)

    John Kosek


    The absence of high-temperature electronics is an obstacle to the development of untapped energy resources (deep oil, gas and geothermal). US natural gas consumption is projected to grow from 22 trillion cubic feet per year (tcf) in 1999 to 34 tcf in 2020. Cumulatively this is 607 tcf of consumption by 2020, while recoverable reserves using current technology are 177 tcf. A significant portion of this shortfall may be met by tapping deep gas reservoirs. Tapping these reservoirs represents a significant technical challenge. At these depths, temperatures and pressures are very high and may require penetrating very hard rock. Logistics of supporting 6.1 km (20,000 ft) drill strings and the drilling processes are complex and expensive. At these depths up to 50% of the total drilling cost may be in the last 10% of the well depth. Thus, as wells go deeper it is increasingly important that drillers are able to monitor conditions down-hole such as temperature, pressure, heading, etc. Commercial off-the-shelf electronics are not specified to meet these operating conditions. This is due to problems associated with all aspects of the electronics including the resistors and capacitors. With respect to capacitors, increasing temperature often significantly changes capacitance because of the strong temperature dependence of the dielectric constant. Higher temperatures also affect the equivalent series resistance (ESR). High-temperature capacitors usually have low capacitance values because of these dielectric effects and because packages are kept small to prevent mechanical breakage caused by thermal stresses. Electrolytic capacitors do not operate at temperatures above 150oC due to dielectric breakdown. The development of high-temperature capacitors to be used in a high-pressure high-temperature (HPHT) drilling environment was investigated. These capacitors were based on a previously developed high-voltage hybridized capacitor developed at Giner, Inc. in conjunction with a


    Institute of Scientific and Technical Information of China (English)

    Xu Longxiang; Zhang Jinyu; Schweitzer Gerhard


    A high temperature displacement sensor based on the principle of eddy-current is investigated. A new temperature compensation technique by using eddy-current effect is presented to satisfy the special requirement at high temperature up to 550℃. The experiment shows that the temperature compensation technique leads to good temperature stability for the sensors. The variation of the sensitivity as well as the temperature drift of the sensor with temperature compensation technique is only about 7.4% and 90~350 mV at 550℃ compared with that at room temperature, and that of the sensor without temperature compensation technique is about 31.2% and 2~3 V at 550℃ compared with that at room temperature. A new dynamic calibration method for the eddy-current displacement sensor is presented, which is very easy to be realized especially in high frequency and at high temperatures. The high temperature displacement sensors developed are successfully used at temperature up to 550℃ in a magnetic bearing system for more than 100 h.

  12. High Altitude and Heart

    Directory of Open Access Journals (Sweden)

    Murat Yalcin


    Full Text Available Nowadays, situations associated with high altitude such as mountaineering, aviation increasingly draw the attention of people. Gas pressure decreases and hypoxia is encountered when climbing higher. Physiological and pathological responses of human body to different heights are different. Therefore, physiological and pathological changes that may occur together with height and to know the clinical outcomes of these are important . Acute mountain sickness caused by high altitude and high altitude cerebral edema are preventable diseases with appropriate precautions. Atmospheric oxygen decreasing with height, initiates many adaptive mechanisms. These adaptation mechanisms and acclimatization vary widely among individuals because of reasons such as environmental factors, exercise and cold. High altitude causes different changes in the cardiovascular system with various mechanisms. Although normal individuals easily adapt to these changes, this situation can lead to undesirable results in people with heart disease. For this reason, it should be known the effective evaluation of the people with known heart disease before traveling to high altitude and the complications due to the changes with height and the recommendations can be made to these patients. [TAF Prev Med Bull 2011; 10(2.000: 211-222

  13. High temperature storage loop :

    Energy Technology Data Exchange (ETDEWEB)

    Gill, David Dennis; Kolb, William J.


    A three year plan for thermal energy storage (TES) research was created at Sandia National Laboratories in the spring of 2012. This plan included a strategic goal of providing test capability for Sandia and for the nation in which to evaluate high temperature storage (>650ÀC) technology. The plan was to scope, design, and build a flow loop that would be compatible with a multitude of high temperature heat transfer/storage fluids. The High Temperature Storage Loop (HTSL) would be reconfigurable so that it was useful for not only storage testing, but also for high temperature receiver testing and high efficiency power cycle testing as well. In that way, HTSL was part of a much larger strategy for Sandia to provide a research and testing platform that would be integral for the evaluation of individual technologies funded under the SunShot program. DOEs SunShot program seeks to reduce the price of solar technologies to 6/kWhr to be cost competitive with carbon-based fuels. The HTSL project sought to provide evaluation capability for these SunShot supported technologies. This report includes the scoping, design, and budgetary costing aspects of this effort

  14. Highly Thermal Conductive Nanocomposites (United States)

    Sun, Ya-Ping (Inventor); Connell, John W. (Inventor); Veca, Lucia Monica (Inventor)


    Disclosed are methods for forming carbon-based fillers as may be utilized in forming highly thermal conductive nanocomposite materials. Formation methods include treatment of an expanded graphite with an alcohol/water mixture followed by further exfoliation of the graphite to form extremely thin carbon nanosheets that are on the order of between about 2 and about 10 nanometers in thickness. Disclosed carbon nanosheets can be functionalized and/or can be incorporated in nanocomposites with extremely high thermal conductivities. Disclosed methods and materials can prove highly valuable in many technological applications including, for instance, in formation of heat management materials for protective clothing and as may be useful in space exploration or in others that require efficient yet light-weight and flexible thermal management solutions.

  15. Clustering high dimensional data

    DEFF Research Database (Denmark)

    Assent, Ira


    to render traditional clustering algorithms ineffective. The curse of dimensionality, among other effects, means that with increasing number of dimensions, a loss of meaningful differentiation between similar and dissimilar objects is observed. As high-dimensional objects appear almost alike, new approaches...... for clustering are required. Consequently, recent research has focused on developing techniques and clustering algorithms specifically for high-dimensional data. Still, open research issues remain. Clustering is a data mining task devoted to the automatic grouping of data based on mutual similarity. Each cluster...... that provide different cluster models and different algorithmic approaches for cluster detection. Common to all approaches is the fact that they require some underlying assessment of similarity between data objects. In this article, we provide an overview of the effects of high-dimensional spaces...

  16. High-energy detector (United States)

    Bolotnikov, Aleksey E [South Setauket, NY; Camarda, Giuseppe [Farmingville, NY; Cui, Yonggang [Upton, NY; James, Ralph B [Ridge, NY


    The preferred embodiments are directed to a high-energy detector that is electrically shielded using an anode, a cathode, and a conducting shield to substantially reduce or eliminate electrically unshielded area. The anode and the cathode are disposed at opposite ends of the detector and the conducting shield substantially surrounds at least a portion of the longitudinal surface of the detector. The conducting shield extends longitudinally to the anode end of the detector and substantially surrounds at least a portion of the detector. Signals read from one or more of the anode, cathode, and conducting shield can be used to determine the number of electrons that are liberated as a result of high-energy particles impinge on the detector. A correction technique can be implemented to correct for liberated electron that become trapped to improve the energy resolution of the high-energy detectors disclosed herein.

  17. High Resolution Laboratory Spectroscopy

    CERN Document Server

    Brünken, Sandra


    In this short review we will highlight some of the recent advancements in the field of high-resolution laboratory spectroscopy that meet the needs dictated by the advent of highly sensitive and broadband telescopes like ALMA and SOFIA. Among these is the development of broadband techniques for the study of complex organic molecules, like fast scanning conventional absorption spectroscopy based on multiplier chains, chirped pulse instrumentation, or the use of synchrotron facilities. Of similar importance is the extension of the accessible frequency range to THz frequencies, where many light hydrides have their ground state rotational transitions. Another key experimental challenge is the production of sufficiently high number densities of refractory and transient species in the laboratory, where discharges have proven to be efficient sources that can also be coupled to molecular jets. For ionic molecular species sensitive action spectroscopic schemes have recently been developed to overcome some of the limita...

  18. High power microwaves

    CERN Document Server

    Benford, James; Schamiloglu, Edl


    Following in the footsteps of its popular predecessors, High Power Microwaves, Third Edition continues to provide a wide-angle, integrated view of the field of high power microwaves (HPMs). This third edition includes significant updates in every chapter as well as a new chapter on beamless systems that covers nonlinear transmission lines. Written by an experimentalist, a theorist, and an applied theorist, respectively, the book offers complementary perspectives on different source types. The authors address: * How HPM relates historically and technically to the conventional microwave field * The possible applications for HPM and the key criteria that HPM devices have to meet in order to be applied * How high power sources work, including their performance capabilities and limitations * The broad fundamental issues to be addressed in the future for a wide variety of source types The book is accessible to several audiences. Researchers currently in the field can widen their understanding of HPM. Present or pot...

  19. High-tech entrepreneurship

    DEFF Research Database (Denmark)

    Bernasconi, Michel; Harris, Simon; Mønsted, Mette

    ; entrepreneurial finance; marketing technological innovations; and high-tech incubation management. Including case studies to give practical insights into genuine business examples, this comprehensive book has a distinctly 'real-world' focus throughout.Edited by a multi-national team, this comprehensive book......High-tech businesses form a crucial part of entrepreneurial activity - in some ways representing very typical examples of entrepreneurship, yet in some ways representing quite different challenges. The uncertainty in innovation and advanced technology makes it difficult to use conventional economic...... planning models, and also means that the management skills used in this area must be more responsive to issues of risk, uncertainty and evaluation than in conventional business opportunities. Whilst entrepreneurial courses do reflect the importance of high-tech businesses, they often lack the resources...

  20. High-conflict divorce. (United States)

    Johnston, J R


    This article reviews available research studies of high-conflict divorce and its effects on children. Interparental conflict after divorce (defined as verbal and physical aggression, overt hostility, and distrust) and the primary parent's emotional distress are jointly predictive of more problematic parent-child relationships and greater child emotional and behavioral maladjustment. As a group, children of high-conflict divorce as defined above, especially boys, are two to four times more likely to be clinically disturbed in emotions and behavior compared with national norms. Court-ordered joint physical custody and frequent visitation arrangements in high-conflict divorce tend to be associated with poorer child outcomes, especially for girls. Types of intervention programs and social policy appropriate for these kinds of families are presented.

  1. Citing for High Impact

    CERN Document Server

    Shi, Xiaolin; McFarland, Daniel A


    The question of citation behavior has always intrigued scientists from various disciplines. While general citation patterns have been widely studied in the literature we develop the notion of citation projection graphs by investigating the citations among the publications that a given paper cites. We investigate how patterns of citations vary between various scientific disciplines and how such patterns reflect the scientific impact of the paper. We find that idiosyncratic citation patterns are characteristic for low impact papers; while narrow, discipline-focused citation patterns are common for medium impact papers. Our results show that crossing-community, or bridging citation patters are high risk and high reward since such patterns are characteristic for both low and high impact papers. Last, we observe that recently citation networks are trending toward more bridging and interdisciplinary forms.

  2. High strength alloys

    Energy Technology Data Exchange (ETDEWEB)

    Maziasz, Phillip James [Oak Ridge, TN; Shingledecker, John Paul [Knoxville, TN; Santella, Michael Leonard [Knoxville, TN; Schneibel, Joachim Hugo [Knoxville, TN; Sikka, Vinod Kumar [Oak Ridge, TN; Vinegar, Harold J [Bellaire, TX; John, Randy Carl [Houston, TX; Kim, Dong Sub [Sugar Land, TX


    High strength metal alloys are described herein. At least one composition of a metal alloy includes chromium, nickel, copper, manganese, silicon, niobium, tungsten and iron. System, methods, and heaters that include the high strength metal alloys are described herein. At least one heater system may include a canister at least partially made from material containing at least one of the metal alloys. At least one system for heating a subterranean formation may include a tubular that is at least partially made from a material containing at least one of the metal alloys.

  3. JUNOS High Availability

    CERN Document Server

    Sonderegger, James; Milne, Kieran; Palislamovic, Senad


    Whether your network is a complex carrier or just a few machines supporting a small enterprise, JUNOS High Availability will help you build reliable and resilient networks that include Juniper Networks devices. With this book's valuable advice on software upgrades, scalability, remote network monitoring and management, high-availability protocols such as VRRP, and more, you'll have your network uptime at the five, six, or even seven nines -- or 99.99999% of the time. Rather than focus on "greenfield" designs, the authors explain how to intelligently modify multi-vendor networks. You'll learn

  4. High Pressure Biomass Gasification

    Energy Technology Data Exchange (ETDEWEB)

    Agrawal, Pradeep K [Georgia Tech Research Corporation, Atlanta, GA (United States)


    According to the Billion Ton Report, the U.S. has a large supply of biomass available that can supplement fossil fuels for producing chemicals and transportation fuels. Agricultural waste, forest residue, and energy crops offer potential benefits: renewable feedstock, zero to low CO2 emissions depending on the specific source, and domestic supply availability. Biomass can be converted into chemicals and fuels using one of several approaches: (i) biological platform converts corn into ethanol by using depolymerization of cellulose to form sugars followed by fermentation, (ii) low-temperature pyrolysis to obtain bio-oils which must be treated to reduce oxygen content via HDO hydrodeoxygenation), and (iii) high temperature pyrolysis to produce syngas (CO + H2). This last approach consists of producing syngas using the thermal platform which can be used to produce a variety of chemicals and fuels. The goal of this project was to develop an improved understanding of the gasification of biomass at high pressure conditions and how various gasification parameters might affect the gasification behavior. Since most downstream applications of synags conversion (e.g., alcohol synthesis, Fischer-Tropsch synthesis etc) involve utilizing high pressure catalytic processes, there is an interest in carrying out the biomass gasification at high pressure which can potentially reduce the gasifier size and subsequent downstream cleaning processes. It is traditionally accepted that high pressure should increase the gasification rates (kinetic effect). There is also precedence from coal gasification literature from the 1970s that high pressure gasification would be a beneficial route to consider. Traditional approach of using thermogravimetric analyzer (TGA) or high-pressure themogravimetric analyzer (PTGA) worked well in understanding the gasification kinetics of coal gasification which was useful in designing high pressure coal gasification processes. However

  5. High strength alloys (United States)

    Maziasz, Phillip James; Shingledecker, John Paul; Santella, Michael Leonard; Schneibel, Joachim Hugo; Sikka, Vinod Kumar; Vinegar, Harold J.; John, Randy Carl; Kim, Dong Sub


    High strength metal alloys are described herein. At least one composition of a metal alloy includes chromium, nickel, copper, manganese, silicon, niobium, tungsten and iron. System, methods, and heaters that include the high strength metal alloys are described herein. At least one heater system may include a canister at least partially made from material containing at least one of the metal alloys. At least one system for heating a subterranean formation may include a tublar that is at least partially made from a material containing at least one of the metal alloys.

  6. High-level verification

    CERN Document Server

    Lerner, Sorin; Kundu, Sudipta


    Given the growing size and heterogeneity of Systems on Chip (SOC), the design process from initial specification to chip fabrication has become increasingly complex. This growing complexity provides incentive for designers to use high-level languages such as C, SystemC, and SystemVerilog for system-level design. While a major goal of these high-level languages is to enable verification at a higher level of abstraction, allowing early exploration of system-level designs, the focus so far for validation purposes has been on traditional testing techniques such as random testing and scenario-based

  7. High Performance FORTRAN (United States)

    Mehrotra, Piyush


    High performance FORTRAN is a set of extensions for FORTRAN 90 designed to allow specification of data parallel algorithms. The programmer annotates the program with distribution directives to specify the desired layout of data. The underlying programming model provides a global name space and a single thread of control. Explicitly parallel constructs allow the expression of fairly controlled forms of parallelism in particular data parallelism. Thus the code is specified in a high level portable manner with no explicit tasking or communication statements. The goal is to allow architecture specific compilers to generate efficient code for a wide variety of architectures including SIMD, MIMD shared and distributed memory machines.

  8. High availability IT services

    CERN Document Server

    Critchley, Terry


    This book starts with the basic premise that a service is comprised of the 3Ps-products, processes, and people. Moreover, these entities and their sub-entities interlink to support the services that end users require to run and support a business. This widens the scope of any availability design far beyond hardware and software. It also increases the potential for service failure for reasons beyond just hardware and software; the concept of logical outages. High Availability IT Services details the considerations for designing and running highly available ""services"" and not just the systems

  9. High Temperature Electrolysis

    DEFF Research Database (Denmark)

    Elder, Rachael; Cumming, Denis; Mogensen, Mogens Bjerg


    High temperature electrolysis of carbon dioxide, or co-electrolysis of carbon dioxide and steam, has a great potential for carbon dioxide utilisation. A solid oxide electrolysis cell (SOEC), operating between 500 and 900. °C, is used to reduce carbon dioxide to carbon monoxide. If steam is also...... input to the cell then hydrogen is produced giving syngas. This syngas can then be further reacted to form hydrocarbon fuels and chemicals. Operating at high temperature gives much higher efficiencies than can be achieved with low temperature electrolysis. Current state of the art SOECs utilise a dense...

  10. Prevention of High Blood Pressure (United States)

    ... page from the NHLBI on Twitter. Prevention of High Blood Pressure Healthy lifestyle habits, proper use of medicines, and ... prevent high blood pressure or its complications. Preventing High Blood Pressure Onset Healthy lifestyle habits can help prevent high ...

  11. High-Energy Physics. (United States)

    Creutz, Michael


    Experimentalists in particle physics have long regarded computers as essential components of their apparatus. Theorists are now finding that significant advances in some areas can be accomplished only in partnership with a machine. Needs of experimentalists, interests of theorists, and specialized computers for high-energy experiments are…

  12. Ghana's high forests

    NARCIS (Netherlands)

    Oduro, K.A.


    Deforestation and forest degradation in the tropics have been receiving both scientific and political attention in recent decades due to its impacts on the environment and on human livelihoods. In Ghana, the continuous decline of forest resources and the high demand for timber have raised stakeholde

  13. High frequency electromagnetic dosimetry

    CERN Document Server

    Sánchez-Hernández, David A


    Along with the growth of RF and microwave technology applications, there is a mounting concern about the possible adverse effects over human health from electromagnetic radiation. Addressing this issue and putting it into perspective, this groundbreaking resource provides critical details on the latest advances in high frequency electromagnetic dosimetry.

  14. High energy battery. Hochenergiebatterie

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, H.; Beyermann, G.; Bulling, M.


    In a high energy battery with a large number of individual cells in a housing with a cooling medium flowing through it, it is proposed that the cooling medium should be guided so that it only affects one or both sides of the cells thermally.

  15. Hypertension (High Blood Pressure) (United States)

    ... over the years led to verification of the important role of high blood pressure—especially in concert with ... is specific for that person will be an important key to improving prevention, ... an international team of investigators, funded in part by the NIH, ...

  16. High Density Matter

    Directory of Open Access Journals (Sweden)

    Stone J.R.


    Full Text Available The microscopic composition and properties of matter at super-saturation densities have been the subject of intense investigation for decades. The scarcity of experimental and observational data has led to the necessary reliance on theoretical models. There remains great uncertainty in these models which, of necessity, have to go beyond the over-simple assumption that high density matter consists only of nucleons and leptons. Heavy strange baryons, mesons and quark matter in different forms and phases have to be included to fulfil basic requirements of fundamental laws of physics. In this contribution latest developments in construction of the Equation of State (EoS of high-density matter at zero and finite temperature assuming different composition of matter will be discussed. Critical comparison of model EoS with available experimental data from heavy ion collisions and observations on neutron stars, including gravitational mass, radii and cooling patterns and data on X-ray burst sources and low mass X-ray binaries are made. Fundamental differences between the EoS of low-density, high temperature matter, such as is created in heavy ion collisions and of high-density, low temperature compact objects is discussed.

  17. High Power Cryogenic Targets

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Smith


    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  18. Carthage High School Baseball. (United States)

    Woodfin, Samantha, Ed.


    This is the third issue of the magazine to focus on baseball in Panola County (Texas). The issue salutes the Carthage High School baseball program during two periods of its history. The first period was the early 1940's under Coach E. B. Morrison, whose teams were State Finalists in 1941 and 1942. The second period covered is the era of Coach…

  19. High Blood Pressure Prevention (United States)

    ... or "no added salt." Look for the sodium content in milligrams and the Percent Daily Value. Aim for foods that are less than 5 percent of the Daily Value of sodium. Foods with 20 percent or more Daily Value of sodium are considered high. To learn more about reading nutrition labels, see ...

  20. Highly oxidized superconductors (United States)

    Morris, Donald E.


    Novel superconducting materials in the form of compounds, structures or phases are formed by performing otherwise known syntheses in a highly oxidizing atmosphere rather than that created by molecular oxygen at atmospheric pressure or below. This leads to the successful synthesis of novel superconducting compounds which are thermodynamically stable at the conditions under which they are formed.

  1. High availability using virtualization

    CERN Document Server

    Calzolari, Federico


    High availability has always been one of the main problems for a data center. Till now high availability was achieved by host per host redundancy, a highly expensive method in terms of hardware and human costs. A new approach to the problem can be offered by virtualization. Using virtualization, it is possible to achieve a redundancy system for all the services running on a data center. This new approach to high availability allows to share the running virtual machines over the servers up and running, by exploiting the features of the virtualization layer: start, stop and move virtual machines between physical hosts. The system (3RC) is based on a finite state machine with hysteresis, providing the possibility to restart each virtual machine over any physical host, or reinstall it from scratch. A complete infrastructure has been developed to install operating system and middleware in a few minutes. To virtualize the main servers of a data center, a new procedure has been developed to migrate physical to virtu...

  2. High temperature superconducting compounds (United States)

    Goldman, Allen M.


    The major accomplishment of this grant has been to develop techniques for the in situ preparation of high-Tc superconducting films involving the use of ozone-assisted molecular beam epitaxy. The techniques are generalizable to the growth of trilayer and multilayer structures. Films of both the DyBa2Cu3O(7-x) and YBa2Cu3O(7-x) compounds as well as the La(2-x)Sr(x)CuO4 compound have been grown on the usual substrates, SrTiO3, YSZ, MgO, and LaAlO3, as well as on Si substrates without any buffer layer. A bolometer has been fabricated on a thermally isolated SiN substrate coated with YSZ, an effort carried out in collaboration with Honeywell Inc. The deposition process facilitates the fabrication of very thin and transparent films creating new opportunities for the study of superconductor-insulator transitions and the investigation of photo-doping with carriers of high temperature superconductors. In addition to a thin film technology, a patterning technology has been developed. Trilayer structures have been developed for FET devices and tunneling junctions. Other work includes the measurement of the magnetic properties of bulk single crystal high temperature superconductors, and in collaboration with Argonne National Laboratory, measurement of electric transport properties of T1-based high-Tc films.

  3. High Temperature Piezoelectric Drill (United States)

    Bao, Xiaoqi; Scott, James; Boudreau, Kate; Bar-Cohen, Yoseph; Sherrit, Stewart; Badescu, Mircea; Shrout, Tom; Zhang, Shujun


    The current NASA Decadal mission planning effort has identified Venus as a significant scientific target for a surface in-situ sampling/analyzing mission. The Venus environment represents several extremes including high temperature (460 deg C), high pressure (9 MPa), and potentially corrosive (condensed sulfuric acid droplets that adhere to surfaces during entry) environments. This technology challenge requires new rock sampling tools for these extreme conditions. Piezoelectric materials can potentially operate over a wide temperature range. Single crystals, like LiNbO3, have a Curie temperature that is higher than 1000 deg C and the piezoelectric ceramics Bismuth Titanate higher than 600 deg C. A study of the feasibility of producing piezoelectric drills that can operate in the temperature range up to 500 deg C was conducted. The study includes the high temperature properties investigations of engineering materials and piezoelectric ceramics with different formulas and doping. The drilling performances of a prototype Ultrasonic/Sonic Drill/Corer (USDC) using high temperate piezoelectric ceramics and single crystal were tested at temperature up to 500 deg C. The detailed results of our study and a discussion of the future work on performance improvements are presented in this paper.

  4. Highly Expressive Hakka Art

    Institute of Scientific and Technical Information of China (English)



    SOUTHERN Jiangxi Province was the birthplace of the Hakka ethnic group and has since been the native home and main transfer hub for the spread of the nationality. The highly expressive art of the Hakkas, including folk songs in Xingguo, colored lantern performances in Shicheng, ancient

  5. High School Press Freedom. (United States)

    Maurer, Diana J.

    This report focuses on controversial articles written by the high school press, decisions made by the courts regarding students' press freedoms, and reactions to the articles and rulings. Particular attention is given to two rulings concerning censorship of articles about students' sexual atttiudes and activities, the issue of prior restraint of…

  6. High blood pressure - infants (United States)

    ... on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics . 2004;114 (2 Suppl 4th Report):555-576. PMID: 15286277 . Review Date 5/6/2016 Updated by: Scott I ...

  7. Danish High Performance Concretes

    DEFF Research Database (Denmark)

    Nielsen, M. P.; Christoffersen, J.; Frederiksen, J.


    In this paper the main results obtained in the research program High Performance Concretes in the 90's are presented. This program was financed by the Danish government and was carried out in cooperation between The Technical University of Denmark, several private companies, and Aalborg University...

  8. Preventing High Blood Pressure (United States)

    ... Web Sites Division for Heart Disease and Stroke Prevention Stroke Heart Disease Cholesterol Salt Million Hearts® WISEWOMAN Preventing High Blood Pressure: Healthy Living Habits Recommend on Facebook Tweet Share Compartir By living a healthy lifestyle, you can help keep your blood pressure in ...

  9. High Blood Pressure Facts (United States)

    ... More black women than men have high blood pressure. 2 Race of Ethnic Group Men (%) Women (%) African Americans 43.0 45.7 Mexican Americans 27.8 28.9 Whites 33.9 31.3 All 34.1 32.7 Top of Page Why Blood Pressure Matters View this graphic snapshot of blood pressure ...

  10. High Performance Magnets (United States)


    Our efforts in this project were focused on three different materials, namely; interstitial Sm-Fe carbides and nitrides, high energy product Nd2Fe14B ...magnets with MgO addition, and nanocomposite Nd2Fe14B /alpha-Fe consisting of a fine mixture of hard and soft phases. In the Sm-Fe carbides and

  11. High-resolution headlamp (United States)

    Gut, Carsten; Cristea, Iulia; Neumann, Cornelius


    The following article shall describe how human vision by night can be influenced. At first, front lighting systems that are already available on the market will be described, followed by their analysis with respect to the positive effects on traffic safety. Furthermore, how traffic safety by night can be increased since the introduction of high resolution headlamps shall be discussed.

  12. High-Sensitivity Spectrophotometry. (United States)

    Harris, T. D.


    Selected high-sensitivity spectrophotometric methods are examined, and comparisons are made of their relative strengths and weaknesses and the circumstances for which each can best be applied. Methods include long path cells, noise reduction, laser intracavity absorption, thermocouple calorimetry, photoacoustic methods, and thermo-optical methods.…

  13. High Selectivity Oxygen Delignification

    Energy Technology Data Exchange (ETDEWEB)

    Arthur J. Ragauskas


    The overall objective of this program was to develop improved extended oxygen delignification (EOD) technologies for current U.S. pulp mill operations. This was accomplished by: (1) Identifying pulping conditions that optimize O and OO performance; (2) Identifying structural features of lignin that enhance reactivity towards EOD of high kappa pulps; (3) Identifying factors minimizing carbohydrate degradation and improve pulp strength of EOD high kappa pulps; (4) Developing a simple, reproducible method of quantifying yield gains from EOD; and (5) Developing process conditions that significantly reduce the capital requirements of EOD while optimizing the yield benefits. Key research outcomes included, demonstrating the use of a mini-O sequence such as (E+O)Dkf:0.05(E+O) or Dkf:0.05(E+O)(E+O) without interstage washing could capture approximately 60% of the delignification efficiency of a conventional O-stage without the major capital requirements associated with an O-stage for conventional SW kraft pulps. The rate of formation and loss of fiber charge during an O-stage stage can be employed to maximize net fiber charge. Optimal fiber charge development and delignification are two independent parameters and do not parallel each other. It is possible to utilize an O-stage to enhance overall cellulosic fiber charge of low and high kappa SW kraft pulps which is beneficial for physical strength properties. The application of NIR and multi-variant analysis was developed into a rapid and simple method of determining the yield of pulp from an oxygen delignification stage that has real-world mill applications. A focus point of this program was the demonstration that Kraft pulping conditions and oxygen delignification of high and low-kappa SW and HW pulps are intimately related. Improved physical pulp properties and yield can be delivered by controlling the H-factor and active alkali charge. Low AA softwood kraft pulp with a kappa number 30 has an average improvement of 2% in

  14. High Voltage Seismic Generator (United States)

    Bogacz, Adrian; Pala, Damian; Knafel, Marcin


    This contribution describes the preliminary result of annual cooperation of three student research groups from AGH UST in Krakow, Poland. The aim of this cooperation was to develop and construct a high voltage seismic wave generator. Constructed device uses a high-energy electrical discharge to generate seismic wave in ground. This type of device can be applied in several different methods of seismic measurement, but because of its limited power it is mainly dedicated for engineering geophysics. The source operates on a basic physical principles. The energy is stored in capacitor bank, which is charged by two stage low to high voltage converter. Stored energy is then released in very short time through high voltage thyristor in spark gap. The whole appliance is powered from li-ion battery and controlled by ATmega microcontroller. It is possible to construct larger and more powerful device. In this contribution the structure of device with technical specifications is resented. As a part of the investigation the prototype was built and series of experiments conducted. System parameter was measured, on this basis specification of elements for the final device were chosen. First stage of the project was successful. It was possible to efficiently generate seismic waves with constructed device. Then the field test was conducted. Spark gap wasplaced in shallowborehole(0.5 m) filled with salt water. Geophones were placed on the ground in straight line. The comparison of signal registered with hammer source and sparker source was made. The results of the test measurements are presented and discussed. Analysis of the collected data shows that characteristic of generated seismic signal is very promising, thus confirms possibility of practical application of the new high voltage generator. The biggest advantage of presented device after signal characteristics is its size which is 0.5 x 0.25 x 0.2 m and weight approximately 7 kg. This features with small li-ion battery makes

  15. High voltage pulse generator (United States)

    Fasching, George E.


    An improved high-voltage pulse generator has been provided which is especially useful in ultrasonic testing of rock core samples. An N number of capacitors are charged in parallel to V volts and at the proper instance are coupled in series to produce a high-voltage pulse of N times V volts. Rapid switching of the capacitors from the paralleled charging configuration to the series discharging configuration is accomplished by using silicon-controlled rectifiers which are chain self-triggered following the initial triggering of a first one of the rectifiers connected between the first and second of the plurality of charging capacitors. A timing and triggering circuit is provided to properly synchronize triggering pulses to the first SCR at a time when the charging voltage is not being applied to the parallel-connected charging capacitors. Alternate circuits are provided for controlling the application of the charging voltage from a charging circuit to be applied to the parallel capacitors which provides a selection of at least two different intervals in which the charging voltage is turned "off" to allow the SCR's connecting the capacitors in series to turn "off" before recharging begins. The high-voltage pulse-generating circuit including the N capacitors and corresponding SCR's which connect the capacitors in series when triggered "on" further includes diodes and series-connected inductors between the parallel-connected charging capacitors which allow sufficiently fast charging of the capacitors for a high pulse repetition rate and yet allow considerable control of the decay time of the high-voltage pulses from the pulse-generating circuit.

  16. High Temperature ESP Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Jack Booker; Brindesh Dhruva


    The objective of the High Temperature ESP Monitoring project was to develop a downhole monitoring system to be used in wells with bottom hole well temperatures up to 300°C for measuring motor temperature, formation pressure, and formation temperature. These measurements are used to monitor the health of the ESP motor, to track the downhole operating conditions, and to optimize the pump operation. A 220 ºC based High Temperature ESP Monitoring system was commercially released for sale with Schlumberger ESP motors April of 2011 and a 250 ºC system with will be commercially released at the end of Q2 2011. The measurement system is now fully qualified, except for the sensor, at 300 °C.

  17. Desulfurization at high temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Panula-Nikkilae, E.; Kurkela, E.; Mojtahedi, W.


    Two high-temperature desulfurization methods, furnace injection and gasification-desulfurization are presented. In furnace injection, the efficiency of desulfurization is 50-60%, but this method is applied in energy production plants, where flue gas desulfurization cannot be used. Ca-based sorbents are used as desulfurization material. Factors affecting desulfurization and the effect of injection on the boiler and ash handling are discussed. In energy production based on gasification, very low sulfur emissions can be achieved by conventional low-temperature cleanup. However, high-temperature gas cleaning leads to higher efficiency and can be applied to smaller size classes. Ca-, Fe-, or Zn-based sorbents or mixed metals can be used for desulfurization. Most of the methods under development are based on the use of regenerative sorbents in a cleanup reactor located outside the gasifier. So far, only calcium compounds have been used for desulfurization inside the gasifier.

  18. High integrity automotive castings

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, D. [Eck Industries Inc., St. Manitowoc, WI (United States)


    This paper described the High Integrity Magnesium Automotive Casting (HI-MAC) program, which was developed to ensure the widespread adoption of magnesium in structural castings. The program will encourage the use of low pressure permanent molds, squeeze casting, and electromagnetic pumping of magnesium into dies. The HI-MAC program is currently investigating new heat treatment methods, and is in the process of creating improved fluid flow and solidification modelling to produce high volume automotive components. In order to address key technology barriers, the program has been divided into 8 tasks: (1) squeeze casting process development; (2) low pressure casting technology; (3) thermal treatment; (4) microstructure control; (5) computer modelling and properties; (6) controlled molten metal transfer and filling; (7) emerging casting technologies; and (8) technology transfer throughout the automotive value chain. Technical challenges were outlined for each of the tasks. 1 ref., 3 tabs., 5 figs.

  19. High Energy Particle Accelerators

    CERN Multimedia

    Audio Productions, Inc, New York


    Film about the different particle accelerators in the US. Nuclear research in the US has developed into a broad and well-balanced program.Tour of accelerator installations, accelerator development work now in progress and a number of typical experiments with high energy particles. Brookhaven, Cosmotron. Univ. Calif. Berkeley, Bevatron. Anti-proton experiment. Negative k meson experiment. Bubble chambers. A section on an electron accelerator. Projection of new accelerators. Princeton/Penn. build proton synchrotron. Argonne National Lab. Brookhaven, PS construction. Cambridge Electron Accelerator; Harvard/MIT. SLAC studying a linear accelerator. Other research at Madison, Wisconsin, Fixed Field Alternate Gradient Focusing. (FFAG) Oakridge, Tenn., cyclotron. Two-beam machine. Comments : Interesting overview of high energy particle accelerators installations in the US in these early years. .

  20. High energy beam lines (United States)

    Marchetto, M.; Laxdal, R. E.


    The ISAC post accelerator comprises an RFQ, DTL and SC-linac. The high energy beam lines connect the linear accelerators as well as deliver the accelerated beams to two different experimental areas. The medium energy beam transport (MEBT) line connects the RFQ to the DTL. The high energy beam transport (HEBT) line connects the DTL to the ISAC-I experimental stations (DRAGON, TUDA-I, GPS). The DTL to superconducting beam (DSB) transport line connects the ISAC-I and ISAC-II linacs. The superconducting energy beam transport (SEBT) line connects the SC linac to the ISAC-II experimental station (TUDA-II, HERACLES, TIGRESS, EMMA and GPS). All these lines have the function of transporting and matching the beams to the downstream sections by manipulating the transverse and longitudinal phase space. They also contain diagnostic devices to measure the beam properties.

  1. High Resolution Acoustical Imaging (United States)


    1028 (September 1982). 26 G. Arfken , Mathematical Methods for Physicists (Academic Press, New York, 1971), 2nd printing, pp.662-666. 27 W. R. Hahn...difference in the approach used by the two methods , as noted in the previous paragraph, forming a direct mathematical com- parison may be impossible...examines high resolution methods which use a linear array to locate stationary objects which have scattered the fressure waves. Several;- new methods

  2. High resolution differential thermometer

    Directory of Open Access Journals (Sweden)

    Gotra Z. Yu.


    Full Text Available Main schematic solutions of differential thermometers with measurement resolution about 0.001°C are considered. Differential temperature primary transducer realized on a transistor differential circuit in microampere mode. Analytic calculation and schematic mathematic simulation of primary transducer are fulfilled. Signal transducer is realized on a high precision Zero-Drift Single-Supply Rail-to-Rail operation amplifier AD8552 and 24-Bit S-D microconverter ADuC834.

  3. High Power Switching Transistor (United States)

    Hower, P. L.; Kao, Y. C.; Carnahan, D. C.


    Improved switching transistors handle 400-A peak currents and up to 1,200 V. Using large diameter silicon wafers with twice effective area as D60T, form basis for D7 family of power switching transistors. Package includes npn wafer, emitter preform, and base-contact insert. Applications are: 25to 50-kilowatt high-frequency dc/dc inverters, VSCF converters, and motor controllers for electrical vehicles.

  4. High Altitude Cerebral Edema (United States)


    Saussure offered a monetary prize for the first ascent up Mt. Blanc, the highest peak in Europe, in the hopes that this might encourage guides to... Saussure found himself on the summit where he wrote: "I was constantly forced to interrupt my work and devote myself entirely to breathing...the kind... Saussure HB: cited in Houston CS, Going High. The Story of Man and Altitude. Burlington, Vt., Charles S. Houston, M.D., 1980, p., 32. 9. Delamare JP

  5. Ultra high resolution tomography

    Energy Technology Data Exchange (ETDEWEB)

    Haddad, W.S.


    Recent work and results on ultra high resolution three dimensional imaging with soft x-rays will be presented. This work is aimed at determining microscopic three dimensional structure of biological and material specimens. Three dimensional reconstructed images of a microscopic test object will be presented; the reconstruction has a resolution on the order of 1000 A in all three dimensions. Preliminary work with biological samples will also be shown, and the experimental and numerical methods used will be discussed.

  6. Highly Concurrent Scalar Processing. (United States)


    rearrangement arise from data dependencies between instructions, hence it is critical that artificial - dependencies are eliminated whenever possible...An important class of artificial depen- *. dencies arise due to register reuse. In the following example, no parallelism can be • . exploited in the...specific procedure call site. The use of inteligent procedure expansion techniques is expected to be crucial to the achievement of high performance

  7. High Performance RAIT

    Institute of Scientific and Technical Information of China (English)

    JamesHughes; CharlesMilligan; 等


    The ability to move 10s of TeraBytes in reasonable amounts of time are critical to many of the High Energy Physics applications.This paper examines the issues of high performance,high reliability tape storage systems,and presents the results of a 2-year ASCI Path Forward program to be able to reliably move 1GB/s to an archive that can last 20 years.This paper will cover the requirements.approach,hardware,application software,interface descriptions,performance,measured reliability and predicted reliability.This paper will also touch on future directions for this research.The current research allows systems to sustain 80MB/s of uncompressable data per Fibre Channel interface which is striped out to 8 or more drives.This looks to the application as a single tape drive from both mout and data transfer perspectives .Striping 12 RAIT systems together will provide nearly 1GB/s to tape.The reliability is provided by a method of adding parity tapes to the data stripes.For example,adding 2 parity tapes to an 8-stripe group will allow any 2 of the 10 tapes to be lost or damaged without loss of information.The reliability of RAIT with 8 stripes and 2 parities exceeds that of mirrored tapes while RAIT uses 10 tapes instead of the 16 tapes that a mirror would require.The results of this paper is to be abloe to understand the applicability of RAIT and to be able to understand when it may be useful in High Energy Physics applications.

  8. High Performance Biocomputation (United States)


    ab initio calculation of a small protein has been reported (1PNH, a scorpion toxin with 31 residues and 500 atoms; [3]). Hybrid classical and first...challenge can be characterized as highly computationally-savvy and fully capable of effectively exploiting state-of-the-art capability. However, there...enilarrassingly parallel comlrltations, where little or no comnmiinication is required), capacity computing is an effective approac-h. A recent extension of

  9. High power beam analysis (United States)

    Aharon, Oren


    In various modern scientific and industrial laser applications, beam-shaping optics manipulates the laser spot size and its intensity distribution. However the designed laser spot frequently deviates from the design goal due to real life imperfections and effects, such as: input laser distortions, optical distortion, heating, overall instabilities, and non-linear effects. Lasers provide the ability to accurately deliver large amounts of energy to a target area with very high accuracy. Thus monitoring beam size power and beam location is of high importance for high quality results and repeatability. Depending on the combination of wavelength, beam size and pulse duration , laser energy is absorbed by the material surface, yielding into processes such as cutting, welding, surface treatment, brazing and many other applications. This article will cover the aspect of laser beam measurements, especially at the focal point where it matters the most. A brief introduction to the material processing interactions will be covered, followed by fundamentals of laser beam propagation, novel measurement techniques, actual measurement and brief conclusions.

  10. High redshift blazars

    CERN Document Server

    Ghisellini, G


    Blazars are sources whose jet is pointing to us. Since their jets are relativistic, the flux is greatly amplified in the direction of motion, making blazars the most powerful persistent objects in the Universe. This is true at all frequencies, but especially where their spectrum peaks. Although the spectrum of moderate powerful sources peaks in the ~GeV range, extremely powerful sources at high redshifts peak in the ~MeV band. This implies that the hard X-ray band is the optimal one to find powerful blazars beyond a redshift of ~4. First indications strongly suggest that powerful high-z blazars harbor the most massive and active early black holes, exceeding a billion solar masses. Since for each detected blazars there must exist hundreds of similar, but misaligned, sources, the search for high-z blazars is becoming competitive with the search of early massive black holes using radio-quiet quasars. Finding how the two populations of black holes (one in jetted sources, the other in radio-quiet objects) evolve i...

  11. High speed preprocessing system

    Indian Academy of Sciences (India)

    M Sankar Kishore


    In systems employing tracking, the area of interest is recognized using a high resolution camera and is handed overto the low resolution receiver. The images seen by the low resolution receiver and by the operator through the high resolution camera are different in spatial resolution. In order to establish the correlation between these two images, the high-resolution camera image needsto be preprocessed and made similar to the low-resolution receiver image. This paper discusses the implementation of a suitable preprocessing technique, emphasis being given to develop a system both in hardware and software to reduce processing time. By applying different software/hardware techniques, the execution time has been brought down from a few seconds to a few milliseconds for a typical set of conditions. The hardware is designed around i486 processors and software is developed in PL/M. The system is tested to match the images obtained by two different sensors of the same scene. The hardware and software have been evaluated with different sets of images.

  12. High pressure ceramic joint (United States)

    Ward, Michael E.; Harkins, Bruce D.


    Many recuperators have components which react to corrosive gases and are used in applications where the donor fluid includes highly corrosive gases. These recuperators have suffered reduced life, increased service or maintenance, and resulted in increased cost. The present joint when used with recuperators increases the use of ceramic components which do not react to highly corrosive gases. Thus, the present joint used with the present recuperator increases the life, reduces the service and maintenance, and reduces the increased cost associated with corrosive action of components used to manufacture recuperators. The present joint is comprised of a first ceramic member, a second ceramic member, a mechanical locking device having a groove defined in one of the first ceramic member and the second ceramic member. The joint and the mechanical locking device is further comprised of a refractory material disposed in the groove and contacting the first ceramic member and the second ceramic member. The present joint mechanically provides a high strength load bearing joint having good thermal cycling characteristics, good resistance to a corrosive environment and good steady state strength at elevated temperatures.

  13. High energy physics

    Energy Technology Data Exchange (ETDEWEB)

    Kernan, A.; Shen, B.C.; Ma, E.


    This proposal is for the continuation of the High Energy Physics program at the University of California at Riverside. In hadron collider physics the authors will complete their transition from experiment UA1 at CERN to the DZERO experiment at Fermilab. On experiment UA1 their effort will concentrate on data analysis at Riverside. At Fermilab they will coordinate the high voltage system for all detector elements. They will also carry out hardware/software development for the D0 muon detector. The TPC/Two-Gamma experiment has completed its present phase of data-taking after accumulating 160 pb{sup {minus}}1 of luminosity. The UC Riverside group will continue data and physics analysis and make minor hardware improvement for the high luminosity run. The UC Riverside group is participating in design and implementation of the data acquisition system for the OPAL experiment at LEP. Mechanical and electronics construction of the OPAL hadron calorimeter strip readout system is proceeding on schedule. Data analysis and Monte Carlo detector simulation efforts are proceeding in preparation for the first physics run when IEP operation comenses in fall 1989.

  14. High-voltage picoamperemeter

    Energy Technology Data Exchange (ETDEWEB)

    Bugl, Andrea; Ball, Markus; Boehmer, Michael; Doerheim, Sverre; Hoenle, Andreas; Konorov, Igor [Technische Universitaet Muenchen, Garching (Germany); Ketzer, Bernhard [Technische Universitaet Muenchen, Garching (Germany); Helmholtz-Institut fuer Strahlen- und Kernphysik, Bonn (Germany)


    Current measurements in the nano- and picoampere region on high voltage are an important tool to understand charge transfer processes in micropattern gas detectors like the Gas Electron Multiplier (GEM). They are currently used to e.g. optimize the field configuration in a multi-GEM stack to be used in the ALICE TPC after the upgrade of the experiment during the 2nd long shutdown of the LHC. Devices which allow measurements down to 1pA at high voltage up to 6 kV have been developed at TU Muenchen. They are based on analog current measurements via the voltage drop over a switchable shunt. A microcontroller collects 128 digital ADC values and calculates their mean and standard deviation. This information is sent with a wireless transmitting unit to a computer and stored in a root file. A nearly unlimited number of devices can be operated simultaneously and read out by a single receiver. The results can also be displayed on a LCD directly at the device. Battery operation and the wireless readout are important to protect the user from any contact to high voltage. The principle of the device is explained, and systematic studies of their properties are shown.

  15. High Thermal Conductivity Materials

    CERN Document Server

    Shinde, Subhash L


    Thermal management has become a ‘hot’ field in recent years due to a need to obtain high performance levels in many devices used in such diverse areas as space science, mainframe and desktop computers, optoelectronics and even Formula One racing cars! Thermal solutions require not just taking care of very high thermal flux, but also ‘hot spots’, where the flux densities can exceed 200 W/cm2. High thermal conductivity materials play an important role in addressing thermal management issues. This volume provides readers a basic understanding of the thermal conduction mechanisms in these materials and discusses how the thermal conductivity may be related to their crystal structures as well as microstructures developed as a result of their processing history. The techniques for accurate measurement of these properties on large as well as small scales have been reviewed. Detailed information on the thermal conductivity of diverse materials including aluminum nitride (AlN), silicon carbide (SiC), diamond, a...

  16. High Altitude Dermatology (United States)

    Singh, Lt. Col. G K


    Approximately, 140 million people worldwide live permanently at high altitudes (HAs) and approximately another 40 million people travel to HA area (HAA) every year for reasons of occupation, sports or recreation. In India, whole of Ladakh region, part of Northwest Kashmir, Northern part of Sikkim and Tenga valley of Arunachal are considered inhabited areas of HAA. The low quantity of oxygen, high exposure of ultraviolet (UV) light, very low humidity, extreme subzero temperature in winter, high wind velocity, make this region difficult for lowlanders as well as for tourists. Acute mountain sickness, HA pulmonary edema, HA cerebral edema, and thromboembolic conditions are known to occur in HA. However, enough knowledge has not been shared on dermatoses peculiar to this region. Xerosis, UV-related skin disorders (tanning, photomelanosis, acute and chronic sunburn, polymorphic light eruption, chronic actinic dermatitis, actinic cheilitis, etc.), cold injuries (frostbite, chilblains, acrocyanosis, erythrocyanosis, etc.) nail changes (koilonychias), airborne contact dermatitis, insect bite reaction, and skin carcinoma (basal cell carcinomas, squamous cell carcinomas, and also rarely malignant melanoma) are the dermatoses seen in HAAs. Early diagnosis and knowledge of HA dermatoses may prevent serious consequences of disease and improve the quality of life for the visitors as well as for native of the place. PMID:28216727

  17. High altitude dermatology

    Directory of Open Access Journals (Sweden)

    G K Singh


    Full Text Available Approximately, 140 million people worldwide live permanently at high altitudes (HAs and approximately another 40 million people travel to HA area (HAA every year for reasons of occupation, sports or recreation. In India, whole of Ladakh region, part of Northwest Kashmir, Northern part of Sikkim and Tenga valley of Arunachal are considered inhabited areas of HAA. The low quantity of oxygen, high exposure of ultraviolet (UV light, very low humidity, extreme subzero temperature in winter, high wind velocity, make this region difficult for lowlanders as well as for tourists. Acute mountain sickness, HA pulmonary edema, HA cerebral edema, and thromboembolic conditions are known to occur in HA. However, enough knowledge has not been shared on dermatoses peculiar to this region. Xerosis, UV-related skin disorders (tanning, photomelanosis, acute and chronic sunburn, polymorphic light eruption, chronic actinic dermatitis, actinic cheilitis, etc., cold injuries (frostbite, chilblains, acrocyanosis, erythrocyanosis, etc. nail changes (koilonychias, airborne contact dermatitis, insect bite reaction, and skin carcinoma (basal cell carcinomas, squamous cell carcinomas, and also rarely malignant melanoma are the dermatoses seen in HAAs. Early diagnosis and knowledge of HA dermatoses may prevent serious consequences of disease and improve the quality of life for the visitors as well as for native of the place.

  18. High temperature interfacial superconductivity (United States)

    Bozovic, Ivan [Mount Sinai, NY; Logvenov, Gennady [Port Jefferson Station, NY; Gozar, Adrian Mihai [Port Jefferson, NY


    High-temperature superconductivity confined to nanometer-scale interfaces has been a long standing goal because of potential applications in electronic devices. The spontaneous formation of a superconducting interface in bilayers consisting of an insulator (La.sub.2CuO.sub.4) and a metal (La.sub.1-xSr.sub.xCuO.sub.4), neither of which is superconducting per se, is described. Depending upon the layering sequence of the bilayers, T.sub.c may be either .about.15 K or .about.30 K. This highly robust phenomenon is confined to within 2-3 nm around the interface. After exposing the bilayer to ozone, T.sub.c exceeds 50 K and this enhanced superconductivity is also shown to originate from a 1 to 2 unit cell thick interfacial layer. The results demonstrate that engineering artificial heterostructures provides a novel, unconventional way to fabricate stable, quasi two-dimensional high T.sub.c phases and to significantly enhance superconducting properties in other superconductors. The superconducting interface may be implemented, for example, in SIS tunnel junctions or a SuFET.

  19. High power coaxial ubitron (United States)

    Balkcum, Adam J.

    In the ubitron, also known as the free electron laser, high power coherent radiation is generated from the interaction of an undulating electron beam with an electromagnetic signal and a static periodic magnetic wiggler field. These devices have experimentally produced high power spanning the microwave to x-ray regimes. Potential applications range from microwave radar to the study of solid state material properties. In this dissertation, the efficient production of high power microwaves (HPM) is investigated for a ubitron employing a coaxial circuit and wiggler. Designs for the particular applications of an advanced high gradient linear accelerator driver and a directed energy source are presented. The coaxial ubitron is inherently suited for the production of HPM. It utilizes an annular electron beam to drive the low loss, RF breakdown resistant TE01 mode of a large coaxial circuit. The device's large cross-sectional area greatly reduces RF wall heat loading and the current density loading at the cathode required to produce the moderate energy (500 keV) but high current (1-10 kA) annular electron beam. Focusing and wiggling of the beam is achieved using coaxial annular periodic permanent magnet (PPM) stacks without a solenoidal guide magnetic field. This wiggler configuration is compact, efficient and can propagate the multi-kiloampere electron beams required for many HPM applications. The coaxial PPM ubitron in a traveling wave amplifier, cavity oscillator and klystron configuration is investigated using linear theory and simulation codes. A condition for the dc electron beam stability in the coaxial wiggler is derived and verified using the 2-1/2 dimensional particle-in-cell code, MAGIC. New linear theories for the cavity start-oscillation current and gain in a klystron are derived. A self-consistent nonlinear theory for the ubitron-TWT and a new nonlinear theory for the ubitron oscillator are presented. These form the basis for simulation codes which, along

  20. High-frequency ECG (United States)

    Tragardh, Elin; Schlegel, Todd T.


    The standard ECG is by convention limited to 0.05-150 Hz, but higher frequencies are also present in the ECG signal. With high-resolution technology, it is possible to record and analyze these higher frequencies. The highest amplitudes of the high-frequency components are found within the QRS complex. In past years, the term "high frequency", "high fidelity", and "wideband electrocardiography" have been used by several investigators to refer to the process of recording ECGs with an extended bandwidth of up to 1000 Hz. Several investigators have tried to analyze HF-QRS with the hope that additional features seen in the QRS complex would provide information enhancing the diagnostic value of the ECG. The development of computerized ECG-recording devices that made it possible to record ECG signals with high resolution in both time and amplitude, as well as better possibilities to store and process the signals digitally, offered new methods for analysis. Different techniques to extract the HF-QRS have been described. Several bandwidths and filter types have been applied for the extraction as well as different signal-averaging techniques for noise reduction. There is no standard method for acquiring and quantifying HF-QRS. The physiological mechanisms underlying HF-QRS are still not fully understood. One theory is that HF-QRS are related to the conduction velocity and the fragmentation of the depolarization wave in the myocardium. In a three-dimensional model of the ventricles with a fractal conduction system it was shown that high numbers of splitting branches are associated with HF-QRS. In this experiment, it was also shown that the changes seen in HF-QRS in patients with myocardial ischemia might be due to the slowing of the conduction velocity in the region of ischemia. This mechanism has been tested by Watanabe et al by infusing sodium channel blockers into the left anterior descending artery in dogs. In their study, 60 unipolar ECGs were recorded from the entire

  1. High Test Peroxide High Sealing Conical Seal Project (United States)

    National Aeronautics and Space Administration — High Test Peroxide (HTP) Highly Compatible High Sealing Conical Seals are necessary for ground test operations and space based applications. Current conical seals...

  2. [Detecting high risk pregnancy]. (United States)

    Doret, Muriel; Gaucherand, Pascal


    Antenatal care is aiming to reduce maternal land foetal mortality and morbidity. Maternal and foetal mortality can be due to different causes. Their knowledge allows identifying pregnancy (high risk pregnancy) with factors associated with an increased risk for maternal and/or foetal mortality and serious morbidity. Identification of high risk pregnancies and initiation of appropriate treatment and/or surveillance should improve maternal and/or foetal outcome. New risk factors are continuously described thanks to improvement in antenatal care and development in biology and cytopathology, increasing complexity in identifying high risk pregnancies. Level of risk can change all over the pregnancy. Ideally, it should be evaluated prior to the pregnancy and at each antenatal visit. Clinical examination is able to screen for intra-uterin growth restriction, pre-eclampsia, threatened for preterm labour; ultrasounds help in the diagnosis of foetal morphological anomalies, foetal chromosomal anomalies, placenta praevia and abnormal foetal growth; biological exams are used to screen for pre-eclampsia, gestational diabetes, trisomy 21 (for which screening method just changed), rhesus immunisation, seroconversion for toxoplasmosis or rubeola, unknown infectious disease (syphilis, hepatitis B, VIH). During pregnancy, most of the preventive strategies have to be initiated during the first trimester or even before conception. Prevention for neural-tube defects, neonatal hypocalcemia and listeriosis should be performed for all women. On the opposite, some measures are concerning only women with risk factors such as prevention for toxoplasmosis, rhesus immunization (which recently changed), tobacco complications and pre-eclampsia and intra-uterine growth factor restriction.

  3. High-fluoride groundwater. (United States)

    Rao, N Subba


    Fluoride (F(-)) is essential for normal bone growth, but its higher concentration in the drinking water poses great health problems and fluorosis is common in many parts of India. The present paper deals with the aim of establishment of facts of the chemical characteristics responsible for the higher concentration of F(-) in the groundwater, after understanding the chemical behavior of F(-) in relation to pH, total alkalinity (TA), total hardness (TH), carbonate hardness (CH), non-carbonate hardness (NCH), and excess alkalinity (EA) in the groundwater observed from the known areas of endemic fluorosis zones of Andhra Pradesh that have abundant sources of F(-)-bearing minerals of the Precambrians. The chemical data of the groundwater shows that the pH increases with increase F(-); the concentration of TH is more than the concentration of TA at low F(-) groundwater, the resulting water is represented by NCH; the TH has less concentration compared to TA at high F(-) groundwater, causing the water that is characterized by EA; and the water of both low and high concentrations of F(-) has CH. As a result, the F(-) has a positive relation with pH and TA, and a negative relation with TH. The operating mechanism derived from these observations is that the F(-) is released from the source into the groundwater by geochemical reactions and that the groundwater in its flowpath is subjected to evapotranspiration due to the influence of dry climate, which accelerates a precipitation of CaCO(3) and a reduction of TH, and thereby a dissolution of F(-). Furthermore, the EA in the water activates the alkalinity in the areas of alkaline soils, leading to enrichment of F(-). Therefore, the alkaline condition, with high pH and EA, and low TH, is a more conducive environment for the higher concentration of F(-) in the groundwater.

  4. High performance steam development

    Energy Technology Data Exchange (ETDEWEB)

    Duffy, T.; Schneider, P. [Solar Turbines Inc., San Diego, CA (United States)


    Over 30 years ago U.S. industry introduced the world`s highest temperature (1200{degrees}F at 5000 psig) and most efficient power plant, the Eddystone coal-burning steam plant. The highest alloy material used in the plant was 316 stainless steel. Problems during the first few years of operation caused a reduction in operating temperature to 1100{degrees}F which has generally become the highest temperature used in plants around the world. Leadership in high temperature steam has moved to Japan and Europe over the last 30 years.

  5. High Performance Liquid Chromatography (United States)

    Talcott, Stephen

    High performance liquid chromatography (HPLC) has many applications in food chemistry. Food components that have been analyzed with HPLC include organic acids, vitamins, amino acids, sugars, nitrosamines, certain pesticides, metabolites, fatty acids, aflatoxins, pigments, and certain food additives. Unlike gas chromatography, it is not necessary for the compound being analyzed to be volatile. It is necessary, however, for the compounds to have some solubility in the mobile phase. It is important that the solubilized samples for injection be free from all particulate matter, so centrifugation and filtration are common procedures. Also, solid-phase extraction is used commonly in sample preparation to remove interfering compounds from the sample matrix prior to HPLC analysis.

  6. Knees Lifted High

    Centers for Disease Control (CDC) Podcasts


    The Eagle Books are a series of four books that are brought to life by wise animal characters - Mr. Eagle, Miss Rabbit, and Coyote - who engage Rain That Dances and his young friends in the joy of physical activity, eating healthy foods, and learning from their elders about health and diabetes prevention. Knees Lifted High gives children fun ideas for active outdoor play.  Created: 8/4/2008 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 8/5/2008.

  7. Highly Sensitive Optical Receivers

    CERN Document Server

    Schneider, Kerstin


    Highly Sensitive Optical Receivers primarily treats the circuit design of optical receivers with external photodiodes. Continuous-mode and burst-mode receivers are compared. The monograph first summarizes the basics of III/V photodetectors, transistor and noise models, bit-error rate, sensitivity and analog circuit design, thus enabling readers to understand the circuits described in the main part of the book. In order to cover the topic comprehensively, detailed descriptions of receivers for optical data communication in general and, in particular, optical burst-mode receivers in deep-sub-µm CMOS are presented. Numerous detailed and elaborate illustrations facilitate better understanding.

  8. ALICE High Level Trigger

    CERN Multimedia

    Alt, T


    The ALICE High Level Trigger (HLT) is a computing farm designed and build for the real-time, online processing of the raw data produced by the ALICE detectors. Events are fully reconstructed from the raw data, analyzed and compressed. The analysis summary together with the compressed data and a trigger decision is sent to the DAQ. In addition the reconstruction of the events allows for on-line monitoring of physical observables and this information is provided to the Data Quality Monitor (DQM). The HLT can process event rates of up to 2 kHz for proton-proton and 200 Hz for Pb-Pb central collisions.

  9. Theoretical High Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Christ, Norman H.; Weinberg, Erick J.


    we provide reports from each of the six faculty supported by the Department of Energy High Energy Physics Theory grant at Columbia University. Each is followed by a bibliography of the references cited. A complete list of all of the publications in the 12/1/2010-04/30/2014 period resulting from research supported by this grant is provided in the following section. The final section lists the Ph.D. dissertations based on research supported by the grant that were submitted during this period.

  10. High energy cosmic rays

    CERN Document Server

    Stanev, Todor


    Offers an accessible text and reference (a cosmic-ray manual) for graduate students entering the field and high-energy astrophysicists will find this an accessible cosmic-ray manual Easy to read for the general astronomer, the first part describes the standard model of cosmic rays based on our understanding of modern particle physics. Presents the acceleration scenario in some detail in supernovae explosions as well as in the passage of cosmic rays through the Galaxy. Compares experimental data in the atmosphere as well as underground are compared with theoretical models

  11. High temperature superconductors

    CERN Document Server

    Paranthaman, Parans


    This essential reference provides the most comprehensive presentation of the state of the art in the field of high temperature superconductors. This growing field of research and applications is currently being supported by numerous governmental and industrial initiatives in the United States, Asia and Europe to overcome grid energy distribution issues. The technology is particularly intended for densely populated areas. It is now being commercialized for power-delivery devices, such as power transmission lines and cables, motors and generators. Applications in electric utilities include current limiters, long transmission lines and energy-storage devices that will help industries avoid dips in electric power.

  12. [High Pressure Gas Tanks (United States)

    Quintana, Rolando


    Four high-pressure gas tanks, the basis of this study, were especially made by a private contractor and tested before being delivered to NASA Kennedy Space Center. In order to insure 100% reliability of each individual tank the staff at KSC decided to again submit the four tanks under more rigorous tests. These tests were conducted during a period from April 10 through May 8 at KSC. This application further validates the predictive safety model for accident prevention and system failure in the testing of four high-pressure gas tanks at Kennedy Space Center, called Continuous Hazard Tracking and Failure Prediction Methodology (CHTFPM). It is apparent from the variety of barriers available for a hazard control that some barriers will be more successful than others in providing protection. In order to complete the Barrier Analysis of the system, a Task Analysis and a Biomechanical Study were performed to establish the relationship between the degree of biomechanical non-conformities and the anomalies found within the system on particular joints of the body. This relationship was possible to obtain by conducting a Regression Analysis to the previously generated data. From the information derived the body segment with the lowest percentage of non-conformities was the neck flexion with 46.7%. Intense analysis of the system was conducted including Preliminary Hazard Analysis (PHA), Failure Mode and Effect Analysis (FMEA), and Barrier Analysis. These analyses resulted in the identification of occurrences of conditions, which may be becoming hazardous in the given system. These conditions, known as dendritics, may become hazards and could result in an accident, system malfunction, or unacceptable risk conditions. A total of 56 possible dendritics were identified. Work sampling was performed to observe the occurrence each dendritic. The out of control points generated from a Weighted c control chart along with a Pareto analysis indicate that the dendritics "Personnel not

  13. Clojure high performance programming

    CERN Document Server

    Kumar, Shantanu


    This is a short, practical guide that will teach you everything you need to know to start writing high performance Clojure code.This book is ideal for intermediate Clojure developers who are looking to get a good grip on how to achieve optimum performance. You should already have some experience with Clojure and it would help if you already know a little bit of Java. Knowledge of performance analysis and engineering is not required. For hands-on practice, you should have access to Clojure REPL with Leiningen.

  14. High performance AC drives

    CERN Document Server

    Ahmad, Mukhtar


    This book presents a comprehensive view of high performance ac drives. It may be considered as both a text book for graduate students and as an up-to-date monograph. It may also be used by R & D professionals involved in the improvement of performance of drives in the industries. The book will also be beneficial to the researchers pursuing work on multiphase drives as well as sensorless and direct torque control of electric drives since up-to date references in these topics are provided. It will also provide few examples of modeling, analysis and control of electric drives using MATLAB/SIMULIN

  15. High risk pregnancy

    Directory of Open Access Journals (Sweden)

    Bernardita Donoso Bernales


    Full Text Available It is estimated that roughly 20% of pregnancies fall into the high risk category, which in turn are responsible for over 80% of perinatal adverse outcome. Modern obstetrics has been very successful in reducing maternal morbidity and mortality. It has focused mainly on fetal and neonatal aspects, and on identifying the subgroup of pregnant women that need greater surveillance and care because of clearly identifiable risk factors. The article describes the preconceptional advice, its components and recommendations for its implementation, as well as its role in maternal and perinatal risk assessment. These interventions attempt to reduce the rates of maternal and perinatal mortality.

  16. High energy electron cooling

    Energy Technology Data Exchange (ETDEWEB)

    Parkhomchuk, V. [Budker Institute of Nuclear Physics, Novosibirsk (Russian Federation)


    High energy electron cooling requires a very cold electron beam. The questions of using electron cooling with and without a magnetic field are presented for discussion at this workshop. The electron cooling method was suggested by G. Budker in the middle sixties. The original idea of the electron cooling was published in 1966. The design activities for the NAP-M project was started in November 1971 and the first run using a proton beam occurred in September 1973. The first experiment with both electron and proton beams was started in May 1974. In this experiment good result was achieved very close to theoretical prediction for a usual two component plasma heat exchange.

  17. High Power Dye Lasers (United States)


    art capabilities for developmental models of hydrogen thyratrons and solid state thyristors. Table II-l is a list of switches that have been... thyratron Table II-l Switch Ignitron GE, GL - 37207 Hydrogen Thyratron High Power Switches Peak Cur. (kA) RMS Cm. (A) 300 120 Max. Rep Rate...for 2 usec Pulse Cli„) 8 1. EG&G HY-5 2. EW. GHT9 3. EG&G Develop- mental model Thyristors 5 7.5 15 125 335 350 300 1000 300 RCA

  18. High-power electronics

    CERN Document Server

    Kapitsa, Petr Leonidovich


    High-Power Electronics, Volume 2 presents the electronic processes in devices of the magnetron type and electromagnetic oscillations in different systems. This book explores the problems of electronic energetics.Organized into 11 chapters, this volume begins with an overview of the motion of electrons in a flat model of the magnetron, taking into account the in-phase wave and the reverse wave. This text then examines the processes of transmission of electromagnetic waves of various polarization and the wave reflection from grids made of periodically distributed infinite metal conductors. Other

  19. Shielding high energy accelerators

    CERN Document Server

    Stevenson, Graham Roger


    After introducing the subject of shielding high energy accelerators, point source, line-of-sight models, and in particular the Moyer model. are discussed. Their use in the shielding of proton and electron accelerators is demonstrated and their limitations noted. especially in relation to shielding in the forward direction provided by large, flat walls. The limitations of reducing problems to those using it cylindrical geometry description are stressed. Finally the use of different estimators for predicting dose is discussed. It is suggested that dose calculated from track-length estimators will generally give the most satisfactory estimate. (9 refs).

  20. High speed flywheel (United States)

    McGrath, Stephen V.


    A flywheel for operation at high speeds utilizes two or more ringlike coments arranged in a spaced concentric relationship for rotation about an axis and an expansion device interposed between the components for accommodating radial growth of the components resulting from flywheel operation. The expansion device engages both of the ringlike components, and the structure of the expansion device ensures that it maintains its engagement with the components. In addition to its expansion-accommodating capacity, the expansion device also maintains flywheel stiffness during flywheel operation.

  1. High Blood Pressure Fact Sheet (United States)

    ... High Blood Pressure Salt Cholesterol Million Hearts® WISEWOMAN High Blood Pressure Fact Sheet Language: English Español (Spanish) Recommend on ... time. High blood pressure is also called hypertension. High Blood Pressure in the United States Having high blood pressure ...

  2. Highly curved microchannel plates (United States)

    Siegmund, O. H. W.; Cully, S.; Warren, J.; Gaines, G. A.; Priedhorsky, W.; Bloch, J.


    Several spherically curved microchannel plate (MCP) stack configurations were studied as part of an ongoing astrophysical detector development program, and as part of the development of the ALEXIS satellite payload. MCP pairs with surface radii of curvature as small as 7 cm, and diameters up to 46 mm have been evaluated. The experiments show that the gain (greater than 1.5 x 10 exp 7) and background characteristics (about 0.5 events/sq cm per sec) of highly curved MCP stacks are in general equivalent to the performance achieved with flat MCP stacks of similar configuration. However, gain variations across the curved MCP's due to variations in the channel length to diameter ratio are observed. The overall pulse height distribution of a highly curved surface MCP stack (greater than 50 percent FWHM) is thus broader than its flat counterpart (less than 30 percent). Preconditioning of curved MCP stacks gives comparable results to flat MCP stacks, but it also decreases the overall gain variations. Flat fields of curved MCP stacks have the same general characteristics as flat MCP stacks.

  3. Giant high occipital encephalocele

    Directory of Open Access Journals (Sweden)

    Agrawal Amit


    Full Text Available Encephaloceles are rare embryological mesenchymal developmental anomalies resulting from inappropriate ossification in skull through with herniation of intracranial contents of the sac. Encephaloceles are classified based on location of the osseous defect and contents of sac. Convexity encephalocele with osseous defect in occipital bone is called occipital encephalocele. Giant occipital encephaloceles can be sometimes larger than the size of baby skull itself and they pose a great surgical challenge. Occipital encephaloceles (OE are further classified as high OE when defect is only in occipital bone above the foramen magnum, low OE when involving occipital bone and foramen magnum and occipito-cervical when there involvement of occipital bone, foramen magnum and posterior upper neural arches. Chiari III malformation can be associated with high or low occipital encephaloceles. Pre-operatively, it is essential to know the size of the sac, contents of the sac, relation to the adjacent structures, presence or absence of venous sinuses/vascular structures and osseous defect size. Sometimes it becomes imperative to perform both CT and MRI for the necessary information. Volume rendered CT images can depict the relation of osseous defect to foramen magnum and provide information about upper neural arches which is necessary in classifying these lesions.

  4. High speed optical networks (United States)

    Frankel, Michael Y.; Livas, Jeff


    This overview will discuss core network technology and cost trade-offs inherent in choosing between "analog" architectures with high optical transparency, and ones heavily dependent on frequent "digital" signal regeneration. The exact balance will be related to the specific technology choices in each area outlined above, as well as the network needs such as node geographic spread, physical connectivity patterns, and demand loading. Over the course of a decade, optical networks have evolved from simple single-channel SONET regenerator-based links to multi-span multi-channel optically amplified ultra-long haul systems, fueled by high demand for bandwidth at reduced cost. In general, the cost of a well-designed high capacity system is dominated by the number of optical to electrical (OE) and electrical to optical (EO) conversions required. As the reach and channel capacity of the transport systems continued to increase, it became necessary to improve the granularity of the demand connections by introducing (optical add/drop multiplexers) OADMs. Thus, if a node requires only small demand connectivity, most of the optical channels are expressed through without regeneration (OEO). The network costs are correspondingly reduced, partially balanced by the increased cost of the OADM nodes. Lately, the industry has been aggressively pursuing a natural extension of this philosophy towards all-optical "analog" core networks, with each demand touching electrical digital circuitry only at the in/egress nodes. This is expected to produce a substantial elimination of OEO costs, increase in network capacity, and a notionally simpler operation and service turn-up. At the same time, such optical "analog" network requires a large amount of complicated hardware and software for monitoring and manipulating high bit rate optical signals. New and more complex modulation formats that provide resiliency to both optical noise and nonlinear propagation effects are important for extended


    Directory of Open Access Journals (Sweden)

    Gembong Baskoro


    Full Text Available This paper discuses the concept of managing high-end, high-volume innovative products. High-end, high-volume consumer products are products that have considerable influence to the way of life. Characteristic of High-end, high-volume consumer products are (1 short cycle time, (2 quick obsolete time, and (3 rapid price erosion. Beside the disadvantages that they are high risk for manufacturers, if manufacturers are able to understand precisely the consumer needs then they have the potential benefit or success to be the market leader. High innovation implies to high utilization of the user, therefore these products can influence indirectly to the way of people life. The objective of managing them is to achieve sustainability of the products development and innovation. This paper observes the behavior of these products in companies operated in high-end, high-volume consumer product.

  6. High tech cheating. (United States)

    Harper, Mary G


    The use of technology has enhanced the convenience, flexibility, and efficiency of both preparatory and continuing education. Unfortunately, academic dishonesty, including plagiarism, has shown a positive correlation with the increased use of technology in education. A review of the literature related to unintended outcomes of the use of technology in nursing education and continuing education was conducted to determine the ethical implications for the nursing profession. Although nursing research dealing with academic and professional misconduct is sparse, evidence suggests that academic dishonesty is a predictor of workplace dishonesty. Given this correlation between unethical classroom behavior and unethical clinical behavior, efforts to staunch academic dishonesty may help allay professional misconduct. A combination of high tech and low tech methods may be used to minimize unethical behaviors among students and practicing professional nurses in order to maintain the integrity of the profession.

  7. High Voltage Charge Pump

    KAUST Repository

    Emira, Ahmed A.


    Various embodiments of a high voltage charge pump are described. One embodiment is a charge pump circuit that comprises a plurality of switching stages each including a clock input, a clock input inverse, a clock output, and a clock output inverse. The circuit further comprises a plurality of pumping capacitors, wherein one or more pumping capacitors are coupled to a corresponding switching stage. The circuit also comprises a maximum selection circuit coupled to a last switching stage among the plurality of switching stages, the maximum selection circuit configured to filter noise on the output clock and the output clock inverse of the last switching stage, the maximum selection circuit further configured to generate a DC output voltage based on the output clock and the output clock inverse of the last switching stage.

  8. Resonant High Power Combiners

    CERN Document Server

    Langlois, Michel; Peillex-Delphe, Guy


    Particle accelerators need radio frequency sources. Above 300 MHz, the amplifiers mostly used high power klystrons developed for this sole purpose. As for military equipment, users are drawn to buy "off the shelf" components rather than dedicated devices. IOTs have replaced most klystrons in TV transmitters and find their way in particle accelerators. They are less bulky, easier to replace, more efficient at reduced power. They are also far less powerful. What is the benefit of very compact sources if huge 3 dB couplers are needed to combine the power? To alleviate this drawback, we investigated a resonant combiner, operating in TM010 mode, able to combine 3 to 5 IOTs. Our IOTs being able to deliver 80 kW C.W. apiece, combined power would reach 400 kW minus the minor insertion loss. Values for matching and insertion loss are given. The behavior of the system in case of IOT failure is analyzed.

  9. High Temperature Aquifer Storage (United States)

    Ueckert, Martina; Niessner, Reinhard; Baumann, Thomas


    Combined heat and power generation (CHP) is highly efficient because excess heat is used for heating and/or process energy. However, the demand of heat energy varies considerably throughout the year while the demand for electrical energy is rather constant. It seems economically and ecologically highly beneficial for municipalities and large power consumers such as manufacturing plants to store excess heat in groundwater aquifers and to recuperate this energy at times of higher demand. Within the project High Temperature Aquifer Storage, scientists investigate storage and recuperation of excess heat energy into the bavarian Malm aquifer. Apart from high transmissivity and favorable pressure gradients, the hydrochemical conditions are crucial for long-term operation. An enormous technical challenge is the disruption of the carbonate equilibrium - modeling results indicated a carbonate precipitation of 10 - 50 kg/d in the heat exchangers. The test included five injection pulses of hot water (60 °C up to 110 °C) and four tracer pulses, each consisting of a reactive and a conservative fluorescent dye, into a depth of about 300 m b.s.l. resp. 470 m b.s.l. Injection and production rates were 15 L/s. To achieve the desired water temperatures, about 4 TJ of heat energy were necessary. Electrical conductivity, pH and temperature were recorded at a bypass where also samples were taken. A laboratory container at the drilling site was equipped for analysing the concentration of the dyes and the major cations at sampling intervals of down to 15 minutes. Additional water samples were taken and analysed in the laboratory. The disassembled heat exchanger prooved that precipitation was successfully prevented by adding CO2 to the water before heating. Nevertheless, hydrochemical data proved both, dissolution and precipitation processes in the aquifer. This was also suggested by the hydrochemical modelling with PhreeqC and is traced back to mixture dissolution and changing

  10. Streamflows at record highs (United States)

    Streamflow was reported well above average in more than half the country during May, with flows at or near record levels for the month in 22 states, according to the U.S. Geological Survey (USGS), Department of the Interior.USGS hydrologists said that above average flow was reported at 98 of the 173 USGS key index gauging stations used in their monthly check on surface- and ground-water conditions. High flows were most prevalent in the Mississippi River basin states and in the east, with the exception of Maine, South Carolina, and Georgia. Below-average streamflow occurred in the Pacific northwest and in small scattered areas in Colorado, Kansas, Texas, and Minnesota.

  11. High energy astrophysical techniques

    CERN Document Server

    Poggiani, Rosa


    This textbook presents ultraviolet and X-ray astronomy, gamma-ray astronomy, cosmic ray astronomy, neutrino astronomy, and gravitational wave astronomy as distinct research areas, focusing on the astrophysics targets and the requirements with respect to instrumentation and observation methods. The purpose of the book is to bridge the gap between the reference books and the specialized literature. For each type of astronomy, the discussion proceeds from the orders of magnitude for observable quantities. The physical principles of photon and particle detectors are then addressed, and the specific telescopes and combinations of detectors, presented. Finally the instruments and their limits are discussed with a view to assisting readers in the planning and execution of observations. Astronomical observations with high-energy photons and particles represent the newest additions to multimessenger astronomy and this book will be of value to all with an interest in the field.

  12. High Temperature Piezoelectric Drill (United States)

    Bao, Xiaoqi; Bar-Cohen, Yoseph; Sherrit, Stewart; Badescu, Mircea; Shrout, Tom


    Venus is one of the planets in the solar systems that are considered for potential future exploration missions. It has extreme environment where the average temperature is 460 deg C and its ambient pressure is about 90 atm. Since the existing actuation technology cannot maintain functionality under the harsh conditions of Venus, it is a challenge to perform sampling and other tasks that require the use of moving parts. Specifically, the currently available electromagnetic actuators are limited in their ability to produce sufficiently high stroke, torque, or force. In contrast, advances in developing electro-mechanical materials (such as piezoelectric and electrostrictive) have enabled potential actuation capabilities that can be used to support such missions. Taking advantage of these materials, we developed a piezoelectric actuated drill that operates at the temperature range up to 500 deg C and the mechanism is based on the Ultrasonic/Sonic Drill/Corer (USDC) configuration. The detailed results of our study are presented in this paper

  13. High energy physics

    Energy Technology Data Exchange (ETDEWEB)

    Kernan, A.; Shen, B.C.; Ma, E.


    Hadron collider studies will focus on: (i) the search for the top quark with the newly installed D0 detector at the Fermilab Tevatron collider, (ii) the upgrade of the D0 detector to match the new main injector luminosity and (iii) R&D on silicon microstrip tracking devices for the SSC. High statistics studies of Z{sup 0} decay will continue with the OPAL detector at LEP. These studies will include a direct measurement of Z decay to neutrinos, the search for Higgs and heavy quark decays of Z. Preparations for the Large Scintillation Neutrino Detector (LSND) to measure neutrino oscillations at LAMPF will focus on data acquisition and testing of photomultiplier tubes. In the theoretical area E. Ma will concentrate on mass-generating radiative mechanisms for light quarks and leptons in renormalizable gauge field theories. J. Wudka`s program includes a detailed investigation of the magnetic-flip approach to the solar neutrino.

  14. High Density QCD

    CERN Document Server

    Ducati, M B G


    The dynamics of high partonic density QCD is presented considering, in the double logarithm approximation, the parton recombination mechanism built in the AGL formalism, developed including unitarity corrections for the nucleon as well for nucleus. It is shown that these corrections are under theoretical control. The resulting non linear evolution equation is solved in the asymptotic regime, and a comprehensive phenomenology concerning Deep Inelastic Scattering like $F_2$, $F_L$, $F_2^c$. $\\partial F_2/ \\partial \\ln Q^2$, $\\partial F^A_2/ \\partial \\ln Q^2$, etc, is presented. The connection of our formalism with the DGLAP and BFKL dynamics, and with other perturbative (K) and non-perturbative (MV-JKLW) approaches is analised in detail. The phenomena of saturation due to shadowing corrections and the relevance of this effect in ion physics and heavy quark production is emphasized. The implications to e-RHIC, HERA-A, and LHC physics and some open questions are mentioned.

  15. Very high energy neutrinos (United States)

    Moscoso, Luciano; Spiering, Christian


    A sky survey with neutrinos may considerably extend our understanding of cosmic phenomena. Due to the low interaction cross section of neutrinos with matter and due to the high cosmic ray background the detector must be very large (of the order of 1 km 3) and must be shielded. These new devices consist of a network of photo-tubes which are deployed in the depth of the ocean, of a lake or of the ice of South Pole. The detection of the Cherenkov light emitted by muons produced in muon neutrino interactions with the matter surrounding the detector will allow the reconstruction of the neutrino direction with an angular resolution of the order or lower than one degree. Several projects are underway. Their status will be reviewed in this paper.

  16. HIGH SPEED CAMERA (United States)

    Rogers, B.T. Jr.; Davis, W.C.


    This patent relates to high speed cameras having resolution times of less than one-tenth microseconds suitable for filming distinct sequences of a very fast event such as an explosion. This camera consists of a rotating mirror with reflecting surfaces on both sides, a narrow mirror acting as a slit in a focal plane shutter, various other mirror and lens systems as well as an innage recording surface. The combination of the rotating mirrors and the slit mirror causes discrete, narrow, separate pictures to fall upon the film plane, thereby forming a moving image increment of the photographed event. Placing a reflecting surface on each side of the rotating mirror cancels the image velocity that one side of the rotating mirror would impart, so as a camera having this short a resolution time is thereby possible.

  17. Highly trifluoromethylated platinum compounds. (United States)

    Martínez-Salvador, Sonia; Forniés, Juan; Martín, Antonio; Menjón, Babil


    The homoleptic, square-planar organoplatinum(II) compound [NBu(4)](2) [Pt(CF(3))(4)] (1) undergoes oxidative addition of CF(3) I under mild conditions to give rise to the octahedral organoplatinum(IV) complex [NBu(4)](2) [Pt(CF(3))(5)I] (2). This highly trifluoromethylated species reacts with Ag(+) salts of weakly coordinating anions in Me(2)CO under a wet-air stream to afford the aquo derivative [NBu(4)][Pt(CF(3))(5) (OH(2))] (4) in around 75% yield. When the reaction of 2 with the same Ag(+) salts is carried out in MeCN, the solvento compound [NBu(4) ][Pt(CF(3))(5)(NCMe)] (5) is obtained in around 80% yield. The aquo ligand in 4 as well as the MeCN ligand in 5 are labile and can be cleanly replaced by neutral and anionic ligands to furnish a series of pentakis(trifluoromethyl)platinate(IV) compounds with formulae [NBu(4)][Pt(CF(3))(5) (L)] (L=CO (6), pyridine (py; 7), tetrahydrothiophene (tht; 8)) and [NBu(4)](2) [Pt(CF(3))(5)X] (X=Cl (9), Br (10)). The unusual carbonyl-platinum(IV) derivative [NBu(4)][Pt(CF(3))(5) (CO)] (6) is thermally stable and has a ν(CO) of 2194 cm(-1). The crystal structures of 2⋅CH(2)Cl(2), 5, [PPh(4) ][Pt(CF(3))(5)(CO)] (6'), and 7 have been established by X-ray diffraction methods. Compound 2 has shown itself to be a convenient entry to the chemistry of highly trifluoromethylated platinum compounds. To the best of our knowledge, compounds 2 and 4-10 are the organoelement compounds with the highest CF(3) content to have been isolated and adequately characterized to date.

  18. Chromium at High Pressure (United States)

    Jaramillo, Rafael


    Chromium has long served as the archetype of spin density wave magnetism. Recently, Jaramillo and collaborators have shown that Cr also serves as an archetype of magnetic quantum criticality. Using a combination of x-ray diffraction and electrical transport measurements at high pressures and cryogenic temperatures in a diamond anvil cell, they have demonstrated that the N'eel transition (TN) can be continuously suppressed to zero, with no sign of a concurrent structural transition. The order parameter undergoes a broad regime of exponential suppression, consistent with the weak coupling paradigm, before deviating from a BCS-like ground state within a narrow but accessible quantum critical regime. The quantum criticality is characterized by mean field scaling of TN and non mean field scaling of the transport coefficients, which points to a fluctuation-induced reconstruction of the critical Fermi surface. A comparison between pressure and chemical doping as means to suppress TN sheds light on different routes to the quantum critical point and the relevance of Fermi surface nesting and disorder at this quantum phase transition. The work by Jaramillo et al. is broadly relevant to the study of magnetic quantum criticality in a physically pure and theoretically tractable system that balances elements of weak and strong coupling. [4pt] [1] R. Jaramillo, Y. Feng, J. Wang & T. F. Rosenbaum. Signatures of quantum criticality in pure Cr at high pressure. Proc. Natl. Acad. Sci. USA 107, 13631 (2010). [0pt] [2] R. Jaramillo, Y. Feng, J. C. Lang, Z. Islam, G. Srajer, P. B. Littlewood, D. B. McWhan & T. F. Rosenbaum. Breakdown of the Bardeen-Cooper-Schrieffer ground state at a quantum phase transition. Nature 459, 405 (2009).

  19. FSU High Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Prosper, Harrison B. [Florida State Univ., Tallahassee, FL (United States); Adams, Todd [Florida State Univ., Tallahassee, FL (United States); Askew, Andrew [Florida State Univ., Tallahassee, FL (United States); Berg, Bernd [Florida State Univ., Tallahassee, FL (United States); Blessing, Susan K. [Florida State Univ., Tallahassee, FL (United States); Okui, Takemichi [Florida State Univ., Tallahassee, FL (United States); Owens, Joseph F. [Florida State Univ., Tallahassee, FL (United States); Reina, Laura [Florida State Univ., Tallahassee, FL (United States); Wahl, Horst D. [Florida State Univ., Tallahassee, FL (United States)


    The High Energy Physics group at Florida State University (FSU), which was established in 1958, is engaged in the study of the fundamental constituents of matter and the laws by which they interact. The group comprises theoretical and experimental physicists, who sometimes collaborate on projects of mutual interest. The report highlights the main recent achievements of the group. Significant, recent, achievements of the group’s theoretical physicists include progress in making precise predictions in the theory of the Higgs boson and its associated processes, and in the theoretical understanding of mathematical quantities called parton distribution functions that are related to the structure of composite particles such as the proton. These functions are needed to compare data from particle collisions, such as the proton-proton collisions at the CERN Large Hadron Collider (LHC), with theoretical predictions. The report also describes the progress in providing analogous functions for heavy nuclei, which find application in neutrino physics. The report highlights progress in understanding quantum field theory on a lattice of points in space and time (an area of study called lattice field theory), the progress in constructing several theories of potential new physics that can be tested at the LHC, and interesting new ideas in the theory of the inflationary expansion of the very early universe. The focus of the experimental physicists is the Compact Muon Solenoid (CMS) experiment at CERN. The report, however, also includes results from the D0 experiment at Fermilab to which the group made numerous contributions over a period of many years. The experimental group is particularly interested in looking for new physics at the LHC that may provide the necessary insight to extend the standard model (SM) of particle physics. Indeed, the search for new physics is the primary task of contemporary particle physics, one motivated by the need to explain certain facts, such as the

  20. Living with High Blood Pressure (United States)

    ... page from the NHLBI on Twitter. Living With High Blood Pressure If you have high blood pressure, the best thing to do is to talk ... help you track your blood pressure. Pregnancy Planning High blood pressure can cause problems for mother and baby. High ...

  1. High-Redshift Cosmography

    CERN Document Server

    Vitagliano, Vincenzo; Liberati, Stefano; Viel, Matteo


    We constrain the parameters describing the kinematical state of the universe using a cosmographic approach, which is fundamental in that it requires a very minimal set of assumptions (namely to specify a metric) and does not rely on the dynamical equations for gravity. On the data side, we consider the most recent compilations of Supernovae and Gamma Ray Bursts catalogs. This allows to further extend the cosmographic fit up to $z=6.6$, i.e. up to redshift for which one could start to resolve the low $z$ degeneracy among competing cosmological models. In order to reliably control the cosmographic approach at high redshifts, we adopt the expansion in the improved parameter $y=z/(1+z)$ (as proposed in Class. Quant. Grav., 24 (2007) 5985). This series has the great advantage to hold also for $z>1$ and hence it is the appropriate tool for handling data including non-nearby distance indicators. We find that Gamma Ray Bursts, probing higher redshifts than Supernovae, have constraining power and do require (and stati...


    Directory of Open Access Journals (Sweden)

    E. D. Chertov


    Full Text Available The work is devoted to the creation of a new type of mixer to produce homogeneous mixtures of dissimilar materials applied to recycling of housing and communal services waste. The article describes the design of a dual-chamber device of the original high-temperature vacuum mixer, there investigated the processes occurring in the chambers of such devices. The results of theoretical and experimental research of the process of mixing recycled polyethylene with a mixture of "grinded food waste – Eco wool” are presented. The problem of the optimum choice of bending the curvilinear blades in the working volume of the seal, which is achieved by setting their profile in the form of involute arc of several circles of different radii, is examined . The dependences, allowing to define the limits of the changes of the main mode parameters the angular velocity of rotation of the working body of the mixer using two ways of setting the profile of the curvilinear blade mixer are obtained. Represented design of the mixer is proposed to use for a wide range of tasks associated with the mixing of the components with a strongly pronounced difference of physic al chemical properties and, in particular, in the production of composites out of housing and communal services waste.

  3. EURISOL High Power Targets

    CERN Document Server

    Kadi, Y; Lindroos, M; Ridikas, D; Stora, T; Tecchio, L; CERN. Geneva. BE Department


    Modern Nuclear Physics requires access to higher yields of rare isotopes, that relies on further development of the In-flight and Isotope Separation On-Line (ISOL) production methods. The limits of the In-Flight method will be applied via the next generation facilities FAIR in Germany, RIKEN in Japan and RIBF in the USA. The ISOL method will be explored at facilities including ISAC-TRIUMF in Canada, SPIRAL-2 in France, SPES in Italy, ISOLDE at CERN and eventually at the very ambitious multi-MW EURISOL facility. ISOL and in-flight facilities are complementary entities. While in-flight facilities excel in the production of very short lived radioisotopes independently of their chemical nature, ISOL facilities provide high Radioisotope Beam (RIB) intensities and excellent beam quality for 70 elements. Both production schemes are opening vast and rich fields of nuclear physics research. In this article we will introduce the targets planned for the EURISOL facility and highlight some of the technical and safety cha...

  4. High temperature materials and mechanisms

    CERN Document Server


    The use of high-temperature materials in current and future applications, including silicone materials for handling hot foods and metal alloys for developing high-speed aircraft and spacecraft systems, has generated a growing interest in high-temperature technologies. High Temperature Materials and Mechanisms explores a broad range of issues related to high-temperature materials and mechanisms that operate in harsh conditions. While some applications involve the use of materials at high temperatures, others require materials processed at high temperatures for use at room temperature. High-temperature materials must also be resistant to related causes of damage, such as oxidation and corrosion, which are accelerated with increased temperatures. This book examines high-temperature materials and mechanisms from many angles. It covers the topics of processes, materials characterization methods, and the nondestructive evaluation and health monitoring of high-temperature materials and structures. It describes the ...

  5. High-efficiency CARM

    Energy Technology Data Exchange (ETDEWEB)

    Bratman, V.L.; Kol`chugin, B.D.; Samsonov, S.V.; Volkov, A.B. [Institute of Applied Physics, Nizhny Novgorod (Russian Federation)


    The Cyclotron Autoresonance Maser (CARM) is a well-known variety of FEMs. Unlike the ubitron in which electrons move in a periodical undulator field, in the CARM the particles move along helical trajectories in a uniform magnetic field. Since it is much simpler to generate strong homogeneous magnetic fields than periodical ones for a relatively low electron energy ({Brit_pounds}{le}1-3 MeV) the period of particles` trajectories in the CARM can be sufficiently smaller than in the undulator in which, moreover, the field decreases rapidly in the transverse direction. In spite of this evident advantage, the number of papers on CARM is an order less than on ubitron, which is apparently caused by the low (not more than 10 %) CARM efficiency in experiments. At the same time, ubitrons operating in two rather complicated regimes-trapping and adiabatic deceleration of particles and combined undulator and reversed guiding fields - yielded efficiencies of 34 % and 27 %, respectively. The aim of this work is to demonstrate that high efficiency can be reached even for a simplest version of the CARM. In order to reduce sensitivity to an axial velocity spread of particles, a short interaction length where electrons underwent only 4-5 cyclotron oscillations was used in this work. Like experiments, a narrow anode outlet of a field-emission electron gun cut out the {open_quotes}most rectilinear{close_quotes} near-axis part of the electron beam. Additionally, magnetic field of a small correcting coil compensated spurious electron oscillations pumped by the anode aperture. A kicker in the form of a sloping to the axis frame with current provided a control value of rotary velocity at a small additional velocity spread. A simple cavity consisting of a cylindrical waveguide section restricted by a cut-off waveguide on the cathode side and by a Bragg reflector on the collector side was used as the CARM-oscillator microwave system.

  6. High-intensityfocusedultrasoundtreatmentfor patientswithunresectablepancreaticcancer

    Institute of Scientific and Technical Information of China (English)

    Peng-Zhou Li; Shai-Hong Zhu; Wei He; Li-Yong Zhu; Sheng-Ping Liu; Yan Liu; Guo-Hui Wang; Fei Ye


    BACKGROUND: High-intensity focused ultrasound (HIFU) is a non-invasive method of solid tissue ablation therapy. However, only a few studies have reported the effect of HIFU for unresectable pancreatic cancer. This study aimed to evaluate the clinical beneifts, survival time and complications associated with the use of HIFU ablation in patients with unresectable pancreatic cancer. METHODS: Twenty-ifve patients with unresectable pancreatic cancer were enrolled in our study. All patients received HIFU therapy for tumors at least once. The therapeutic effects of HIFU was evaluated in terms of Karnofsky performance status (KPS) scores, pain relief, serum CA19-9, and imaging by B-US and CT before and after the therapy. We also recorded median overall survival time and complications caused by the treatment. RESULTS: In the 25 patients, KPS scores were above 60, and increased KPS was observed in 23 patients after treatment. Pain relief occurred in 23 patients. Serum CA19-9 levels were signiifcantly reduced one month after HIFU treatment and became negative in 5 patients. B-US revealed enhanced tumor echogenicity in 13 patients and decreased tumor blood supply in 9. Tumor necrosis was conifrmed by CT in 8 patients one month after HIFU treatment. The median overall survival time was 10 months, and the 1-year survival rate was 42%. No severe complications were observed after HIFU treatment. CONCLUSION: HIFU can effectively relieve pain, increase KPS, decrease tumor growth and prolong the survival time of patients with unresectable pancreatic cancer.

  7. High regression rate, high density hybrid fuels Project (United States)

    National Aeronautics and Space Administration — This SBIR program will investigate high energy density novel nanofuels combined with high density binders for use with an N2O oxidizer. Terves has developed...

  8. Highly Accurate Sensor for High-Purity Oxygen Determination Project (United States)

    National Aeronautics and Space Administration — In this STTR effort, Los Gatos Research (LGR) and the University of Wisconsin (UW) propose to develop a highly-accurate sensor for high-purity oxygen determination....

  9. High Resolution Formaldehyde Photochemistry (United States)

    Ernest, C. T.; Bauer, D.; Hynes, A. J.


    Formaldehyde (HCHO) is the most abundant and most important organic carbonyl compound in the atmosphere. The sources of formaldehyde are the oxidation of methane, isoprene, acetone, and other volatile organic compounds (VOCs); fossil fuel combustion; and biomass burning. The dominant loss mechanism for formaldehyde is photolysis which occurs via two pathways: (R1) HCHO + hv → HCO + H (R2) HCHO + hv → H2 + CO The first pathway (R1) is referred to as the radical channel, while the second pathway (R2) is referred to as the molecular channel. The products of both pathways play a significant role in atmospheric chemistry. The CO that is produced in the molecular channel undergoes further oxidation to produce CO2. Under atmospheric conditions, the H atom and formyl radical that are produced in the radical channel undergo rapid reactions with O2 to produce the hydroperoxyl radical (HO2) via (R3) and (R4). (R3) HCO + O2 → HO2 + CO (R4) H + O2 → HO2 Thus, for every photon absorbed, the photolysis of formaldehyde can contribute one CO2 molecule to the global greenhouse budget or two HO2 radicals to the tropospheric HOx (OH + HO2) cycle. The HO2 radicals produced during formaldehyde photolysis have also been implicated in the formation of photochemical smog. The HO2 radicals act as radical chain carriers and convert NO to NO2, which ultimately results in the catalytic production of O3. Constraining the yield of HO2 produced via HCHO photolysis is essential for improving tropospheric chemistry models. In this study, both the absorption cross section and the quantum yield of the radical channel (R1) were measured at high resolution over the tropospherically relevant wavelength range 304-330 nm. For the cross section measurements a narrow linewidth Nd:YAG pumped dye laser was used with a multi-pass cell. Partial pressures of HCHO were kept below 0.3 torr. Simultaneous measurement of OH LIF in a flame allowed absolute calibration of the wavelength scale. Pressure

  10. Allina Health System's approach to high tech and high touch. (United States)

    Tam, T A


    All health care providers, regardless of their integration status, must meet customer expectations to maintain market share and viability. The balance between high tech and high touch customer interactions is not a fad or trend. For integrated health systems with the full continuum of medical care, additional challenges are presented by the organization's competing health care delivery and financing components. Allina Health System describes its integrated health system approach to satisfying customer high tech and high touch needs.

  11. The Evaluation of Chemotherapy Effectiveness in the Treatment of Esophageal Cancer Used Docetaxel with Cisplatin Based on the Expression of Different Tumor Markers%基于不同肿瘤标志物的表达水平评估多西他赛联合顺铂治疗食管癌的化疗效果

    Institute of Scientific and Technical Information of China (English)

    王海英; 沈洁; 林权冰; 金璋; 邱恩毅; 陈增边


    目的 观察多西他赛联合顺铂化疗治疗食管癌的效果及部分肿瘤标志物的水平变化情况.方法 对本院收治的50例食管癌患者给予TP方案化疗,静脉滴入多西他赛75mg/m2,d1;静脉滴入顺铂80mg/m2,d1~d3,21d重复,所有患者进行3个周期化疗,监测化疗前后患者4项肿瘤标志物含量CEA、CA19-9、SCC、CA724水平,观察比较临床患者近期疗效、毒副反应、1年生存率、治疗前后不同肿瘤标记物水平变化情况.结果 总有效率( CR+PR)为78%,1年生存率为52%,化疗后患者的临床分期明显降低;主要毒副反应是骨髓抑制,Ⅰ级白细胞下降为13例(26%),Ⅱ级21例(42%),脱发46例(92%),肌肉或关节痛29例(58%),恶心纳差27例(54%),疲劳16例(32%),均经对症处理后得到缓解,化疗不良反应可以耐受,化疗后患者血清CEA、CA19-9、CA724、SCC明显低于化疗前.结论 多西他赛加顺铂化疗配合放疗治疗食管癌临床疗效确切,降低病情分期,毒副反应轻,患者能够耐受,近期疗效可靠,值得临床进一步研究,建议引入肿瘤标志物的疗效评估标准.

  12. 非小细胞肺癌患者外周血ERCC1单核苷酸多态性与顺铂化疗疗效的相关性%Relationship between SNPs of ERCC1 in peripheral blood of NSCLC and effects of cisplatin-based chemotherapy

    Institute of Scientific and Technical Information of China (English)

    李晓惠; 蒋蔚峰; 张贺龙; 张菊


    目的:探讨非小细胞肺癌(NSCLC)患者外周血中ERCC1第118位密码子单核苷酸多态性(SNPs)及与顺铂化疗疗效的相关性.方法:应用荧光偏振(FP)法检测60例NSCLC患者外周血ERCC1118位密码子SNPs,并分析其与顺铂化疗疗效的关系.结果:ERCC1第118位密码子SNPs与NSCLC患者年龄(P=0.25)、性别(P=0.95)、吸烟史(P=0.75)、TNM分期(P=0.45)及组织学类型(P=0.70)无关.GP、NP、DP三种铂类基础化疗方案化疗疗效组问差异无统计学意义,P=0.99.ERCC1第118位密码子C/C基因型组的化疗有效率为48.6%(17/35),而变异型C/T+T/T有效率仅为20%(5/25),X2=5.27 P=0.02.结论:ERCC1 118位密码予SNPs与顺铂化疗疗效相关.

  13. Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin. (United States)

    Grande, Lara; Bretones, Gabriel; Rosa-Garrido, Manuel; Garrido-Martin, Eva M; Hernandez, Teresa; Fraile, Susana; Botella, Luisa; de Alava, Enrique; Vidal, August; Garcia del Muro, Xavier; Villanueva, Alberto; Delgado, M Dolores; Fernandez-Luna, Jose L


    Testicular germ cell tumors (TGCTs) are highly responsive to and curable by cisplatin-based chemotherapy even in advanced stages. We have studied the molecular mechanisms involved in the induction of apoptosis in response to cisplatin, and found that proapoptotic Noxa is transcriptionally up-regulated following cisplatin exposure, even in the absence of p53, in NTERA2 cisplatin-sensitive cells but not in 1411HP-resistant cells. Blockade of Noxa reduced the apoptotic response of embryonal carcinoma (EC) NTERA2 cells to cisplatin. A detailed analysis of the Noxa promoter revealed that p73 and Sp1-like factors, Sp1 and KLF6, played key roles in the transcriptional control of this gene. Overexpression of TAp73 induced Noxa whereas the dominant negative isoform ΔNp73, reduced the levels of Noxa after cisplatin exposure in NTERA2 and 2102EP. Interestingly, down-regulation of Sp1 increased Noxa expression in response to cisplatin. However, blockade of KLF6 decreased cisplatin-induced up-regulation of Noxa in EC cell lines. In addition, tissue microarray analyses of TGCTs revealed that expression of Noxa correlates with good clinical prognosis in patients with embryonal carcinoma. Thus, our data show the transcriptional network that regulates Noxa in EC cells, which is key for their apoptotic response to cisplatin-based chemotherapy, and propose Noxa as a predictive factor of therapeutic response.

  14. Immediate versus deferred chemotherapy after radical cystectomy in patients with pT3-pT4 or N+ M0 urothelial carcinoma of the bladder (EORTC 30994): an intergroup, open-label, randomised phase 3 trial

    DEFF Research Database (Denmark)

    Sternberg, Cora N; Skoneczna, Iwona; Kerst, J Martijn


    BACKGROUND: Patients with muscle-invasive urothelial carcinoma of the bladder have poor survival after cystectomy. The EORTC 30994 trial aimed to compare immediate versus deferred cisplatin-based combination chemotherapy after radical cystectomy in patients with pT3-pT4 or N+ M0 urothelial carcin...... patient data meta-analysis and biomarker research are needed to further elucidate the potential for survival benefit in subgroups of patients. FUNDING: Lilly, Canadian Cancer Society Research.......BACKGROUND: Patients with muscle-invasive urothelial carcinoma of the bladder have poor survival after cystectomy. The EORTC 30994 trial aimed to compare immediate versus deferred cisplatin-based combination chemotherapy after radical cystectomy in patients with pT3-pT4 or N+ M0 urothelial......, doxorubicin, and cisplatin [high-dose MVAC], or MVAC) or six cycles of deferred chemotherapy at relapse, with stratification for institution, pT category, and lymph node status according to the number of nodes dissected. Neither patients nor investigators were masked. Overall survival was the primary endpoint...

  15. High Efficency Lightweight Radiators Project (United States)

    National Aeronautics and Space Administration — XC Associates proposes to build on prior work to develop and characterize a very high efficiency, lightweight radiator constructed from high thermal conductivity...

  16. High Energy Density Capacitors Project (United States)

    National Aeronautics and Space Administration — NASA?s future space science missions cannot be realized without the state of the art energy storage devices which require high energy density, high reliability, and...

  17. High Blood Pressure Increasing Worldwide (United States)

    ... page: High Blood Pressure Increasing Worldwide And health risks may appear even ... of people around the world with elevated or high blood pressure increases, so do the number of deaths linked ...

  18. Medications for High Blood Pressure (United States)

    ... Consumers Home For Consumers Consumer Updates Medications for High Blood Pressure Share Tweet Linkedin Pin it More sharing options ... age and you cannot tell if you have high blood pressure by the way you feel, so have your ...

  19. What Causes High Blood Pressure? (United States)

    ... page from the NHLBI on Twitter. Causes of High Blood Pressure Changes, either from genes or the environment, in ... and blood vessel structure and function. Biology and High Blood Pressure Researchers continue to study how various changes in ...

  20. High Red Blood Cell Count (United States)

    Symptoms High red blood cell count By Mayo Clinic Staff A high red blood cell count is an increase in oxygen-carrying cells in your bloodstream. Red blood cells transport oxygen from your lungs to tissues throughout ...

  1. High Performance Space Pump Project (United States)

    National Aeronautics and Space Administration — PDT is proposing a High Performance Space Pump based upon an innovative design using several technologies. The design will use a two-stage impeller, high temperature...

  2. High Temperature Electrostrictive Ceramics Project (United States)

    National Aeronautics and Space Administration — TRS Technologies proposes to develop high temperature electrostrictors from bismuth-based ferroelectrics. These materials will exhibit high strain and low loss in...

  3. Stroke and High Blood Pressure (United States)

    ... More How High Blood Pressure Can Lead to Stroke Updated:Dec 2,2016 Stroke and high blood ... Changes That Matter • Find Tools & Resources Show Your Stroke Support! Show your stroke support with our new ...

  4. Controlling your high blood pressure (United States)

    ... Controlling your high blood pressure To use the sharing features on this page, ... JavaScript. Hypertension is another term used to describe high blood pressure. High blood pressure can lead to: Stroke Heart ...

  5. Diagnosis of High Blood Pressure (United States)

    ... page from the NHLBI on Twitter. Diagnosis of High Blood Pressure For most patients, health care providers diagnose high ... are consistently 140/90 mmHg or above. Confirming High Blood Pressure A blood pressure test is easy and painless ...

  6. What Is High Blood Pressure? (United States)

    ... Disease Venous Thromboembolism Aortic Aneurysm More What is High Blood Pressure? Updated:Oct 31,2016 First, let’s define high ... resources . This content was last reviewed October 2016. High Blood Pressure • Home • Get the Facts About HBP Introduction What ...

  7. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... page from the NHLBI on Twitter. Diagnosis of High Blood Pressure For most patients, health care providers diagnose high ... are consistently 140/90 mmHg or above. Confirming High Blood Pressure A blood pressure test is easy and painless ...

  8. Advances in high temperature chemistry

    CERN Document Server

    Eyring, Leroy


    Advances in High Temperature Chemistry, Volume 2 covers the advances in the knowledge of the high temperature behavior of materials and the complex and unfamiliar characteristics of matter at high temperature. The book discusses the dissociation energies and free energy functions of gaseous monoxides; the matrix-isolation technique applied to high temperature molecules; and the main features, the techniques for the production, detection, and diagnosis, and the applications of molecular beams in high temperatures. The text also describes the chemical research in streaming thermal plasmas, as w

  9. Entanglement between low- and high-lying atomic spin waves (United States)

    Ding, D. S.; Wang, K.; Zhang, W.; Shi, S.; Dong, M. X.; Yu, Y. C.; Zhou, Z. Y.; Shi, B. S.; Guo, G. C.


    Establishing a quantum interface between different physical systems is of special importance for developing the practical versatile quantum networks. Entanglement between low- and high-lying atomic spin waves is essential for building up Rydberg-based quantum information engineering, which is also helpful to study the dynamics behavior of entanglement under external perturbations. Here, we report on the successful storage of a single photon as a high-lying atomic spin wave in a quantum regime. By storing a K-vector entanglement between a single photon and low-lying spin wave, we experimentally realize the entanglement between low- and high-lying atomic spin waves in two separated atomic systems. This makes our experiment a primary demonstration of Rydberg quantum memory of entanglement, representing a primary step toward the construction of a hybrid quantum interface.

  10. High Cycle-life Shape Memory Polymer at High Temperature (United States)

    Kong, Deyan; Xiao, Xinli


    High cycle-life is important for shape memory materials exposed to numerous cycles, and here we report shape memory polyimide that maintained both high shape fixity (Rf) and shape recovery (Rr) during the more than 1000 bending cycles tested. Its critical stress is 2.78 MPa at 250 °C, and the shape recovery process can produce stored energy of 0.218 J g-1 at the efficiency of 31.3%. Its high Rf is determined by the large difference in storage modulus at rubbery and glassy states, while the high Rr mainly originates from its permanent phase composed of strong π-π interactions and massive chain entanglements. Both difference in storage modulus and overall permanent phase were preserved during the bending deformation cycles, and thus high Rf and Rr were observed in every cycle and the high cycle-life will expand application areas of SMPs enormously.

  11. Extremely High Current, High-Brightness Energy Recovery Linac

    CERN Document Server

    Ben-Zvi, Ilan; Beavis, Dana; Blaskiewicz, Michael; Bluem, Hans; Brennan, Joseph M; Burger, Al; Burrill, Andrew; Calaga, Rama; Cameron, Peter; Chang, Xiangyun; Cole, Michael; Connolly, Roger; Delayen, Jean R; Favale, Anthony; Gassner, David M; Grimes, Jacob T; Hahn, Harald; Hershcovitch, Ady; Holmes, Douglas; Hseuh Hsiao Chaun; Johnson, Peter; Kayran, Dmitry; Kewisch, Jorg; Kneisel, Peter; Lambiase, Robert; Litvinenko, Vladimir N; McIntyre, Gary; Meng, Wuzheng; Nehring, Thomas; Nicoletti, Tony; Oerter, Brian; Pate, David; Phillips, Larry; Preble, Joseph P; Rank, Jim; Rao, Triveni; Rathke, John; Roser, Thomas; Russo, Thomas; Scaduto, Joseph; Schultheiss, Tom; Segalov, Zvi; Smith, Kevin T; Todd, Alan M M; Warren-Funk, L; Williams, Neville; Wu, Kuo-Chen; Yakimenko, Vitaly; Yip, Kin; Zaltsman, Alex; Zhao, Yongxiang


    Next generation ERL light-sources, high-energy electron coolers, high-power Free-Electron Lasers, powerful Compton X-ray sources and many other accelerators were made possible by the emerging technology of high-power, high-brightness electron beams. In order to get the anticipated performance level of ampere-class currents, many technological barriers are yet to be broken. BNL's Collider-Accelerator Department is pursuing some of these technologies for its electron cooling of RHIC application, as well as a possible future electron-hadron collider. We will describe work on CW, high-current and high-brightness electron beams. This will include a description of a superconducting, laser-photocathode RF gun and an accelerator cavity capable of producing low emittance (about 1 micron rms normalized) one nano-Coulomb bunches at currents of the order of one ampere average.

  12. High rate, high reliability Li/SO2 cells (United States)

    Chireau, R.


    The use of the lithium/sulfur dioxide system for aerospace applications is discussed. The high rate density in the system is compared to some primary systems: mercury zinc, silver zinc, and magnesium oxide. Estimates are provided of the storage life and shelf life of typical lithium sulfur batteries. The design of lithium cells is presented and criteria are given for improving the output of cells in order to achieve high rate and high reliability.

  13. Concept for a new high resolution high intensity diffractometer

    Energy Technology Data Exchange (ETDEWEB)

    Stuhr, U. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)


    A concept of a new time-of-flight powder-diffractometer for a thermal neutral beam tube at SINQ is presented. The design of the instrument optimises the contradictory conditions of high intensity and high resolution. The high intensity is achieved by using many neutron pulses simultaneously. By analysing the time-angle-pattern of the detected neutrons an assignment of the neutrons to a single pulse is possible. (author) 3 figs., tab., refs.

  14. High power evaluation of X-band high power loads

    CERN Document Server

    Matsumoto, Shuji; Syratchev, Igor; Riddone, Germana; Wuensch, Walter


    Several types of X-band high power loads developed for several tens of MW range were designed, fabricated and used for high power tests at X-band facility of KEK. Some of them have been used for many years and few units showed possible deterioration of RF performance. Recently revised-design loads were made by CERN and the high power evaluation was performed at KEK. In this paper, the main requirements are recalled, together with the design features. The high power test results are analysed and presented

  15. Recrystallization of High Carbon Steel during High Strain Rate

    Institute of Scientific and Technical Information of China (English)


    The recrystallization of high carbon steel during high temperature and high speed rolling has been studied by analyzing the stress-strain curves and the austenite grain size.Isothermal multi-pass hot compression at high strain rate was carried out by Gleeble-2000. The austenite grain size was measured by IBAS image analysis system. The results show that static recrystallization occurred at interpass time under pre-finish rolling, and at the finish rolling stage, due to the brief interpass time, static recrystallization can not be found.

  16. High-Temperature Piezoelectric Sensing

    Directory of Open Access Journals (Sweden)

    Xiaoning Jiang


    Full Text Available Piezoelectric sensing is of increasing interest for high-temperature applications in aerospace, automotive, power plants and material processing due to its low cost, compact sensor size and simple signal conditioning, in comparison with other high-temperature sensing techniques. This paper presented an overview of high-temperature piezoelectric sensing techniques. Firstly, different types of high-temperature piezoelectric single crystals, electrode materials, and their pros and cons are discussed. Secondly, recent work on high-temperature piezoelectric sensors including accelerometer, surface acoustic wave sensor, ultrasound transducer, acoustic emission sensor, gas sensor, and pressure sensor for temperatures up to 1,250 °C were reviewed. Finally, discussions of existing challenges and future work for high-temperature piezoelectric sensing are presented.

  17. High permittivity gate dielectric materials

    CERN Document Server


    "The book comprehensively covers all the current and the emerging areas of the physics and the technology of high permittivity gate dielectric materials, including, topics such as MOSFET basics and characteristics, hafnium-based gate dielectric materials, Hf-based gate dielectric processing, metal gate electrodes, flat-band and threshold voltage tuning, channel mobility, high-k gate stack degradation and reliability, lanthanide-based high-k gate stack materials, ternary hafnia and lanthania based high-k gate stack films, crystalline high-k oxides, high mobility substrates, and parameter extraction. Each chapter begins with the basics necessary for understanding the topic, followed by a comprehensive review of the literature, and ultimately graduating to the current status of the technology and our scientific understanding and the future prospects."

  18. Operating mode of high pressure straws with high spatial resolution

    CERN Document Server

    Davkov, K I; Peshekhonov, V D; Cholakov, V D


    The article presents results of studying the operating mode of thin-walled drift tubes (straws) at flushing it with a high-pressure gas mixture, which allowed obtaining extremely high spatial resolution for straw detectors. The results of studying the radiation ageing of straws operating in this mode are also described.

  19. Early Identification of Educationally High Potential and High Risk Children. (United States)

    Keogh, Barbara K.; Smith, Carol E.

    Early identification of educationally high potential and high risk children was investigated by following the same 49 children from kindergarten entrance through grade five of a regular school program. Kindergarten predictive measures were the Bender Gestalt Test and teachers' evaluations; follow-up measures were yearly standard achievement test…

  20. High Efficiency Power Converter for Low Voltage High Power Applications

    DEFF Research Database (Denmark)

    Nymand, Morten

    , and remote power generation for light towers, camper vans, boats, beacons, and buoys etc. A review of current state-of-the-art is presented. The best performing converters achieve moderately high peak efficiencies at high input voltage and medium power level. However, system dimensioning and cost are often...

  1. Pulse Radiolysis at High Temperatures and High Pressures

    DEFF Research Database (Denmark)

    Christensen, H.; Sehested, Knud


    A set-up enabling pulse radiolysis measurements at high temperatures (up to 320°C) and high pressures (up to 140 bar) has been constructed in collaboration between Risö National Laboratory and Studsvik Energiteknik. The cell has been used for experiments with aqueous solutions with the purpose...

  2. Ultra-High Temperature Gratings

    Institute of Scientific and Technical Information of China (English)

    John Canning; Somnath Bandyopadhyay; Michael Stevenson; Kevin Cook


    Regenerated gratings seeded by type-Ⅰ gratings are shown to withstand temperatures beyond 1000 ℃. The method of regeneration offers a new approach to increasing temperature resistance of stable fibre Bragg and other gratings. These ultra-high temperature (UHT) gratings extend the applicability of silicate based components to high temperature applications such as monitoring of smelters and vehicle and aircraft engines to high power fibre lasers.

  3. High SNR Consistent Compressive Sensing


    Kallummil, Sreejith; Kalyani, Sheetal


    High signal to noise ratio (SNR) consistency of model selection criteria in linear regression models has attracted a lot of attention recently. However, most of the existing literature on high SNR consistency deals with model order selection. Further, the limited literature available on the high SNR consistency of subset selection procedures (SSPs) is applicable to linear regression with full rank measurement matrices only. Hence, the performance of SSPs used in underdetermined linear models ...

  4. High Intensity High Charge State ECR Ion Sources

    CERN Document Server

    Leitner, Daniela


    The next-generation heavy ion beam accelerators such as the proposed Rare Isotope Accelerator (RIA), the Radioactive Ion Beam Factory at RIKEN, the GSI upgrade project, the LHC-upgrade, and IMP in Lanzhou require a great variety of high charge state ion beams with a magnitude higher beam intensity than currently achievable. High performance Electron Cyclotron Resonance (ECR) ion sources can provide the flexibility since they can routinely produce beams from hydrogen to uranium. Over the last three decades, ECR ion sources have continued improving the available ion beam intensities by increasing the magnetic fields and ECR heating frequencies to enhance the confinement and the plasma density. With advances in superconducting magnet technology, a new generation of high field superconducting sources is now emerging, designed to meet the requirements of these next generation accelerator projects. The talk will briefly review the field of high performance ECR ion sources and the latest developments for high intens...

  5. High-entropy alloys as high-temperature thermoelectric materials (United States)

    Shafeie, Samrand; Guo, Sheng; Hu, Qiang; Fahlquist, Henrik; Erhart, Paul; Palmqvist, Anders


    Thermoelectric (TE) generators that efficiently recycle a large portion of waste heat will be an important complementary energy technology in the future. While many efficient TE materials exist in the lower temperature region, few are efficient at high temperatures. Here, we present the high temperature properties of high-entropy alloys (HEAs), as a potential new class of high temperature TE materials. We show that their TE properties can be controlled significantly by changing the valence electron concentration (VEC) of the system with appropriate substitutional elements. Both the electrical and thermal transport properties in this system were found to decrease with a lower VEC number. Overall, the large microstructural complexity and lower average VEC in these types of alloys can potentially be used to lower both the total and the lattice thermal conductivity. These findings highlight the possibility to exploit HEAs as a new class of future high temperature TE materials.

  6. High-entropy alloys as high-temperature thermoelectric materials

    Energy Technology Data Exchange (ETDEWEB)

    Shafeie, Samrand [Surface and Microstructure Engineering Group, Materials and Manufacturing Technology, Chalmers University of Technology, SE-41296 Gothenburg (Sweden); Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-41296 Gothenburg (Sweden); Guo, Sheng, E-mail: [Surface and Microstructure Engineering Group, Materials and Manufacturing Technology, Chalmers University of Technology, SE-41296 Gothenburg (Sweden); Hu, Qiang [Institute of Applied Physics, Jiangxi Academy of Sciences, Nanchang 330029 (China); Fahlquist, Henrik [Bruker AXS Nordic AB, 17067 Solna (Sweden); Erhart, Paul [Department of Applied Physics, Chalmers University of Technology, SE-41296 Gothenburg (Sweden); Palmqvist, Anders, E-mail: [Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-41296 Gothenburg (Sweden)


    Thermoelectric (TE) generators that efficiently recycle a large portion of waste heat will be an important complementary energy technology in the future. While many efficient TE materials exist in the lower temperature region, few are efficient at high temperatures. Here, we present the high temperature properties of high-entropy alloys (HEAs), as a potential new class of high temperature TE materials. We show that their TE properties can be controlled significantly by changing the valence electron concentration (VEC) of the system with appropriate substitutional elements. Both the electrical and thermal transport properties in this system were found to decrease with a lower VEC number. Overall, the large microstructural complexity and lower average VEC in these types of alloys can potentially be used to lower both the total and the lattice thermal conductivity. These findings highlight the possibility to exploit HEAs as a new class of future high temperature TE materials.

  7. High Efficiency Power Converter for Low Voltage High Power Applications

    DEFF Research Database (Denmark)

    Nymand, Morten

    , and remote power generation for light towers, camper vans, boats, beacons, and buoys etc. A review of current state-of-the-art is presented. The best performing converters achieve moderately high peak efficiencies at high input voltage and medium power level. However, system dimensioning and cost are often......The topic of this thesis is the design of high efficiency power electronic dc-to-dc converters for high-power, low-input-voltage to high-output-voltage applications. These converters are increasingly required for emerging sustainable energy systems such as fuel cell, battery or photo voltaic based...... determined by the performance at the system worst case operating point which is usually at minimum input voltage and maximum power. Except for the non-regulating V6 converters, all published solutions exhibit a very significant drop in conversion efficiency at minimum input voltage and maximum output power...

  8. Flare physics at high energies (United States)

    Ramaty, R.


    High-energy processes, involving a rich variety of accelerated particle phenomena, lie at the core of the solar flare problem. The most direct manifestation of these processes are high-energy radiations, gamma rays, hard X-rays and neutrons, as well as the accelerated particles themselves, which can be detected in interplanetary space. In the study of astrophysics from the moon, the understanding of these processes should have great importance. The inner solar system environment is strongly influenced by activity on the sun; the physics of solar flares is of great intrinsic interest; and much high-energy astrophysics can be learned from investigations of flare physics at high energies.

  9. High-pressure neutron diffraction

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Hongwu [Los Alamos National Laboratory


    This lecture will cover progress and prospect of applications of high-pressure neutron diffraction techniques to Earth and materials sciences. I will first introduce general high-pressure research topics and available in-situ high-pressure techniques. Then I'll talk about high-pressure neutron diffraction techniques using two types of pressure cells: fluid-driven and anvil-type cells. Lastly, I will give several case studies using these techniques, particularly, those on hydrogen-bearing materials and magnetic transitions.

  10. Brain Food at High Altitude. (United States)

    Jain, Vishal


    Scenic view at high altitude is a pleasure to the eyes, but it has some shortcoming effects as well. High altitude can be divided into different categories, i.e., high altitude (3000-5000 ft), very high altitude (5000-8000 ft), and extreme altitude (above 8000 ft). Much of the population resides at high altitude, and others go there for tourism. Military personnel are also posted there to defend boundaries. As we ascent to high altitude, partial pressure of oxygen reduces, whereas concentration remains the same; this reduces the availability of oxygen to different body parts. This pathophysiological condition is known as hypobaric hypoxia (HH) which leads to oxidative stress and further causes cognitive dysfunction in some cases. Hypoxia causes neurodegeneration in different brain regions; however, the hippocampus is found to be more prone in comparison to other brain regions. As the hippocampus is affected most, therefore, spatial memory is impaired most during such condition. This chapter will give a brief review of the damaging effect of high altitude on cognition and also throw light on possible herbal interventions at high altitude, which can improve cognitive performance as well as provide protection against the deteriorating effect of hypobaric hypoxia at high altitude.

  11. High Speed Switching Micoplasma in High Pressure Gases (United States)

    Wakim, Dani; Staack, David


    Micro-plasma discharges with switching times approaching 1 ns are studied at pressures from 1 to 16 atm. Applications of these devices are robust high speed switching transistors able to withstand electric interference, high temperatures and harsh environments. Measured discharge conditions at 250 psia in Nitrogen are: gas temperature 2900 K, discharge diameter ˜7 μm and electron density ˜10^17 cm-3. High speed switching is achieved by taking advantage of rapid dynamics of instabilities at high pressure and high electron density. The capacitance and inductance of the circuit also significantly affect transients. Tradeoffs are observed in switching times. By reducing capacitances from 10 pF to ˜1pF attainment of steady state conditions can be reduced from 1 us to ˜ 20 ns. However current rise times increase from 1 ns at high capacitance to 20 ns at low capacitance. A decrease in switching time with increased pressure is also observed. Also investigated are configurations with a third electrode acting as a gate or trigger and various high temperature (>2000K) materials such as platinum rhodium alloys and ceria stabilized zirconia ceramics for device fabrication.

  12. High alcohol consumption causes high IgE levels but not high risk of allergic disease

    DEFF Research Database (Denmark)

    Lomholt, Frederikke K; Nielsen, Sune F; Nordestgaard, Børge G


    disease. Genetically, we explored potential causal relationships between alcohol consumption and IgE levels and allergic disease. RESULTS: The multivariable adjusted odds ratio for IgE levels greater than versus less than 150 kU/L and compared with subjects without allergic disease was 2.3 (95% CI, 2......BACKGROUND: High alcohol consumption is associated with high IgE levels in observational studies; however, whether high alcohol consumption leads to high IgE levels and allergic disease is unclear. OBJECTIVE: We tested the hypothesis that high alcohol consumption is associated with high IgE levels...... for the alcohol-metabolizing enzymes alcohol dehydrogenase 1B (ADH-1B; rs1229984) and alcohol dehydrogenase 1c (ADH-1C; rs698). Observationally, we investigated associations between IgE levels and allergic disease (allergic asthma, rhinitis, and eczema) and between alcohol consumption and IgE levels and allergic...

  13. High-Performance Data Converters

    DEFF Research Database (Denmark)

    Steensgaard-Madsen, Jesper

    Novel techniques for multi-bit oversampled data conversion are described. State-of-the-art oversampled data converters are analyzed, leading to the conclusion that their performance is limited mainly by low-resolution signal representation. To increase the resolution, high-performance, high...

  14. CROPS : high tech agricultural robots

    NARCIS (Netherlands)

    Bontsema, J.; Hemming, J.; Pekkeriet, E.J.


    In the EU-funded CROPS (Clever Robots for Crops) project high tech robots are developed for site-specific spraying and selective harvesting of fruit and fruit vegetables. The harvesting robots are being designed to harvest high-value crops such as greenhouse vegetables, fruits in orchards and grapes

  15. Common High Blood Pressure Myths (United States)

    ... Artery Disease Venous Thromboembolism Aortic Aneurysm More Common High Blood Pressure Myths Updated:Dec 9,2016 Knowing the facts ... health. This content was last reviewed October 2016. High Blood Pressure • Home • Get the Facts About HBP Introduction What ...

  16. Plant growth under high salinity

    NARCIS (Netherlands)

    Blom, M.; Brandenburg, W.A.


    Plants most suitable for growing under high saline or even seawater conditions are the ones naturally living under high saline circumstances. A series of tolerant or moderate salt tolerant plants are experimentally tested and described in literature. For many species of this group a threshold value

  17. Green accounts & day high schools

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard


    The arcticle presents the concept of green accounts and describes how it can be used in the daily work and the teaching at day high schools.......The arcticle presents the concept of green accounts and describes how it can be used in the daily work and the teaching at day high schools....

  18. The High Luminosity LHC Project

    CERN Document Server

    Bruning, O


    This presentation reviews the status of the high luminosity LHC project, and highlights the main challenges from the technology and beam physics point of view. It will mention the outcome of the 2015 Cost and Schedule review for the HL-LHC project and summarizes the status of the high field quadrupole and crab cavity development.

  19. High Performance Thin Layer Chromatography. (United States)

    Costanzo, Samuel J.


    Clarifies where in the scheme of modern chromatography high performance thin layer chromatography (TLC) fits and why in some situations it is a viable alternative to gas and high performance liquid chromatography. New TLC plates, sample applications, plate development, and instrumental techniques are considered. (JN)

  20. Cardiovascular physiology at high altitude. (United States)

    Hooper, T; Mellor, A


    The role of the cardiovascular system is to deliver oxygenated blood to the tissues and remove metabolic effluent. It is clear that this complex system will have to adapt to maintain oxygen deliver in the profound hypoxia of high altitude. The literature on the adaptation of both the systemic and pulmonary circulations to high altitude is reviewed.

  1. Specific yield, High Plains aquifer (United States)

    U.S. Geological Survey, Department of the Interior — This raster data set represents specific-yield ranges in the High Plains aquifer of the United States. The High Plains aquifer underlies 112.6 million acres (176,000...

  2. Hyperhalogens and highly electronegative compositions

    Energy Technology Data Exchange (ETDEWEB)

    Jena, Puru; Gantefoer, Gerd


    Hyperhalogens, a new class of highly electronegative species, are now invented. A hyperhalogen is a superhalogen-containing composition in which the electron affinity (EA) of the hyperhalogen is even larger than that of the superhalogens they are composed of. Novel production methods are provided in which highly electronegative species are produced by surrounding a central metal atom by superhalogen moieties.

  3. High-Performance Ball Bearing (United States)

    Bursey, Roger W., Jr.; Haluck, David A.; Olinger, John B.; Owen, Samuel S.; Poole, William E.


    High-performance bearing features strong, lightweight, self-lubricating cage with self-lubricating liners in ball apertures. Designed to operate at high speed (tens of thousands of revolutions per minute) in cryogenic environment like liquid-oxygen or liquid-hydrogen turbopump. Includes inner race, outer race, and cage keeping bearing balls equally spaced.

  4. Saturation and High Density QCD


    Mueller, A. H.


    Recent progress in understanding general properties of high energy scattering near the unitarity limit, where high density gluon components of the wavefunction are dominant, is reviewed. The similarity of the QCD problem and that of reaction-diffusion processes in statistical physics is emphasized. The energy dependence of the saturation momentum and the status of geometric scaling are discussed.

  5. High brilliance and high efficiency: optimized high power diode laser bars (United States)

    Hülsewede, R.; Schulze, H.; Sebastian, J.; Schröder, D.; Meusel, J.; Hennig, P.


    The strong increasing laser market has ongoing demands to reduce the costs of diode laser pumped systems. For that reason JENOPTIK Diode Lab GmbH (JDL) optimized the bar brilliance (small vertical far field divergence) and bar efficiency (higher optical power operation) with respect to the pump applications. High efficiency reduces the costs for mounting and cooling and high brilliance increases the coupling efficiency. Both are carefully adjusted in the 9xx nm - high power diode laser bars for pump applications in disc- and fiber lasers. Based on low loss waveguide structures high brilliance bars with 19° fast axis beam divergence (FWHM) with 58 % maximum efficiency and 27° fast axis beam divergence (FWHM) with 62 % maximum efficiency are developed. Mounted on conductive cooled heat sinks high power operation with lifetime > 20.000 hours at 120 W output power level (50 % filling factor bars) and 80W (20 % filling factor bars) is demonstrated. 808nm bars used as pump sources for Nd:YAG solid state lasers are still dominating in the market. With respect to the demands on high reliability at high power operation current results of a 100 W high power life time test are showing more than 9000 hour operation time for passively cooled packaged high efficiency 50 % filling factor bars. Measurement of the COMD-level after this hard pulse life time test demonstrates very high power levels with no significant droop in COMD-power level. This confirms the high facet stability of JDL's facet technology. New high power diode laser bars with wavelength of 825 nm and 885 nm are still under development and first results are presented.

  6. High-Intensity, High Charge-State Heavy Ion Sources

    CERN Document Server

    Alessi, J


    There are many accelerator applications for high intensity heavy ion sources, with recent needs including dc beams for RIA, and pulsed beams for injection into synchrotrons such as RHIC and LHC. The present status of sources producing high currents of high charge state heavy ions will be reviewed. These sources include ECR, EBIS, and Laser ion sources. The benefits and limitations for these type sources will be described, for both dc and pulsed applications. Possible future improvements in these type sources will also be discussed.

  7. High-energy, high-rate materials processing (United States)

    Marcus, H. L.; Bourell, D. L.; Eliezer, Z.; Persad, C.; Weldon, W.


    The increasingly available range of pulsed-power, high energy kinetic storage devices, such as low-inductance pulse-forming networks, compulsators, and homopolar generators, is presently considered as a basis for industrial high energy/high rate (HEHR) processing to accomplish shock hardening, drilling, rapid surface alloying and melting, welding and cutting, transformation hardening, and cladding and surface melting in metallic materials. Time-temperature-transformation concepts furnish the basis for a fundamental understanding of the potential advantages of this direct pulsed power processing. Attention is given to the HEHR processing of a refractory molybdenum alloy, a nickel-base metallic glass, tungsten, titanium aluminides, and metal-matrix composites.

  8. High Reliability versus High Autonomy: Dryden, Murphy and Patient Safety


    Evans, Robert G.; Cardiff, Karen; Sheps, Sam


    Healthcare is not a high-reliability industry. The adverse event rate is on the order of 10–2; industries such as aviation, nuclear power and railways achieve rates of 10–5 or better. Increasing awareness of this contrast has made “patient safety” a major topic of concern. High reliability in other industries flows from a combination of  “engineered safety,” tight regulation (“high-level constraints”) and the development of a “culture of safety” that recognizes error as a systemic rather than...

  9. High Energy Density Laboratory Astrophysics

    CERN Document Server

    Lebedev, Sergey V


    During the past decade, research teams around the world have developed astrophysics-relevant research utilizing high energy-density facilities such as intense lasers and z-pinches. Every two years, at the International conference on High Energy Density Laboratory Astrophysics, scientists interested in this emerging field discuss the progress in topics covering: - Stellar evolution, stellar envelopes, opacities, radiation transport - Planetary Interiors, high-pressure EOS, dense plasma atomic physics - Supernovae, gamma-ray bursts, exploding systems, strong shocks, turbulent mixing - Supernova remnants, shock processing, radiative shocks - Astrophysical jets, high-Mach-number flows, magnetized radiative jets, magnetic reconnection - Compact object accretion disks, x-ray photoionized plasmas - Ultrastrong fields, particle acceleration, collisionless shocks. These proceedings cover many of the invited and contributed papers presented at the 6th International Conference on High Energy Density Laboratory Astrophys...

  10. High-pressure creep tests (United States)

    Bhattacharyya, S.; Lamoureux, J.; Hales, C.


    The automotive Stirling engine, presently being developed by the U.S. Department of Energy and NASA, uses high-pressure hydrogen as a working fluid; its long-term effects on the properties of alloys are relatively unknown. Hence, creep-rupture testing of wrought and cast high-temperature alloys in high-pressure hydrogen is an essential part of the research supporting the development of the Stirling cycle engine. Attention is given to the design, development, and operation of a 20 MPa hydrogen high-temperature multispecimen creep-rupture possessing high sensitivity. This pressure vessel allows for the simultaneous yet independent testing of six specimens. The results from one alloy, XF-818, are presented to illustrate how reported results are derived from the raw test data.

  11. CMOS pixel sensors on high resistive substrate for high-rate, high-radiation environments

    Energy Technology Data Exchange (ETDEWEB)

    Hirono, Toko, E-mail: [Physikalisches Institute der Universität Bonn, Bonn (Germany); Barbero, Marlon; Breugnon, Patrick; Godiot, Stephanie [CPPM, Aix-Marseille Universite, CNRS/IN2P3, Marseille (France); Gonella, Laura; Hemperek, Tomasz; Hügging, Fabian; Krüger, Hans [Physikalisches Institute der Universität Bonn, Bonn (Germany); Liu, Jian; Pangaud, Patrick [CPPM, Aix-Marseille Universite, CNRS/IN2P3, Marseille (France); Peric, Ivan [IPE, Karlsruher Institut für Technologie, Karlsruhe (Germany); Pohl, David-Leon [Physikalisches Institute der Universität Bonn, Bonn (Germany); Rozanov, Alexandre [CPPM, Aix-Marseille Universite, CNRS/IN2P3, Marseille (France); Rymaszewski, Piotr [Physikalisches Institute der Universität Bonn, Bonn (Germany); Wang, Anqing [CPPM, Aix-Marseille Universite, CNRS/IN2P3, Marseille (France); Wermes, Norbert [Physikalisches Institute der Universität Bonn, Bonn (Germany)


    A depleted CMOS active pixel sensor (DMAPS) has been developed on a substrate with high resistivity in a high voltage process. High radiation tolerance and high time resolution can be expected because of the charge collection by drift. A prototype of DMAPS was fabricated in a 150 nm process by LFoundry. Two variants of the pixel layout were tested, and the measured depletion depths of the variants are 166 μm and 80 μm. We report the results obtained with the prototype fabricated in this technology.

  12. CMOS pixel sensors on high resistive substrate for high-rate, high-radiation environments (United States)

    Hirono, Toko; Barbero, Marlon; Breugnon, Patrick; Godiot, Stephanie; Gonella, Laura; Hemperek, Tomasz; Hügging, Fabian; Krüger, Hans; Liu, Jian; Pangaud, Patrick; Peric, Ivan; Pohl, David-Leon; Rozanov, Alexandre; Rymaszewski, Piotr; Wang, Anqing; Wermes, Norbert


    A depleted CMOS active pixel sensor (DMAPS) has been developed on a substrate with high resistivity in a high voltage process. High radiation tolerance and high time resolution can be expected because of the charge collection by drift. A prototype of DMAPS was fabricated in a 150 nm process by LFoundry. Two variants of the pixel layout were tested, and the measured depletion depths of the variants are 166 μm and 80 μm. We report the results obtained with the prototype fabricated in this technology.

  13. Very-High Efficiency, High Power Laser Diodes Project (United States)

    National Aeronautics and Space Administration — AdTech Photonics, in collaboration with the Center for Advanced Studies in Photonics Research (CASPR) at UMBC, is pleased to submit this proposal entitled ?Very-High...

  14. Simple Motor Control Concept Results High Efficiency at High Velocities (United States)

    Starin, Scott; Engel, Chris


    The need for high velocity motors in space applications for reaction wheels and detectors has stressed the limits of Brushless Permanent Magnet Motors (BPMM). Due to inherent hysteresis core losses, conventional BPMMs try to balance the need for torque verses hysteresis losses. Cong-less motors have significantly less hysteresis losses but suffer from lower efficiencies. Additionally, the inherent low inductance in cog-less motors result in high ripple currents or high switching frequencies, which lowers overall efficiency and increases performance demands on the control electronics.However, using a somewhat forgotten but fully qualified technology of Isotropic Magnet Motors (IMM), extremely high velocities may be achieved at low power input using conventional drive electronics. This paper will discuss the trade study efforts and empirical test data on a 34,000 RPM IMM.

  15. Equation of state of unreacted high explosives at high pressures

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, C-S


    Isotherms of unreacted high explosives (HMX, RDX, and PETN) have been determined to quasi-hydrostatic high pressures below 45 GPa, by using a diamond-anvil cell angle-resolved synchrotron x-ray diffraction method. The equation-of-state parameters (bulk modulus Bo, and its derivatives B' ) are presented for the 3rd-order Birch-Murnaghan formula based on the measured isotherms. The results are also used to retrieve unreacted Hugoniots in these high explosives and to develop the equations of state and kinetic models for composite high explolsivcs such as XTX-8003 and LX-04. The evidence of shear-induced chemistry of HMX in non-hydrostatic conditions is also presented.

  16. Production of High-Intensity, Highly Charged Ions

    CERN Document Server

    Gammino, S


    In the past three decades, the development of nuclear physics facilities for fundamental and applied science purposes has required an increasing current of multicharged ion beams. Multiple ionization implies the formation of dense and energetic plasmas, which, in turn, requires specific plasma trapping configurations. Two types of ion source have been able to produce very high charge states in a reliable and reproducible way: electron beam ion sources (EBIS) and electron cyclotron resonance ion sources (ECRIS). Multiple ionization is also obtained in laser-generated plasmas (laser ion sources (LIS)), where the high-energy electrons and the extremely high electron density allow step-by-step ionization, but the reproducibility is poor. This chapter discusses the atomic physics background at the basis of the production of highly charged ions and describes the scientific and technological features of the most advanced ion sources. Particular attention is paid to ECRIS and the latest developments, since they now r...


    Directory of Open Access Journals (Sweden)

    Ricardo Miranda Alé


    Full Text Available High-Si steel is a low cost alternative for the fabrication of tubular structures resistant to atmospheric corrosion. However, the literature has often pointed out that steels presenting a higher Si content and/or a lower Mn/Si ratio have higher susceptibility to defects at the weld bond line during HFIW (High Frequency Induction Welding process, which has been widely used for manufacturing small diameter tubes. In this study the effect of the HFIW conditions on the quality of steel tubes with high-Si content and low Mn/Si ratio is investigated. The quality of welded tubes was determined by flare test and the defects in the bond line were identified by SEM. It has been found that higher welding speeds, V-convergence angles and power input should be applied in welding of high-Si steel, when compared to similar strength C-Mn steel.

  18. High Temperature, High Frequency Fuel Metering Valve Project (United States)

    National Aeronautics and Space Administration — Active Signal Technologies and its subcontractor Moog propose to develop a high-frequency actuator driven valve intended to achieve TRL 6 by the end of Phase II....

  19. Computer Controlled High Precise,High Voltage Pules Generator

    Institute of Scientific and Technical Information of China (English)

    但果; 邹积岩; 丛吉远; 董恩源


    High precise, high voltage pulse generator made up of high-power IGBT and pulse transformers controlled by a computer are described. A simple main circuit topology employed in this pulse generator can reduce the cost meanwhile it still meets special requirements for pulsed electric fields (PEFs) in food process. The pulse generator utilizes a complex programmable logic device (CPLD) to generate trigger signals. Pulse-frequency, pulse-width and pulse-number are controlled via RS232 bus by a computer. The high voltage pulse generator well suits to the application for fluid food non-thermal effect in pulsed electric fields, for it can increase and decrease by the step length 1.

  20. Website Design Guidelines: High Power Distance and High Context Culture

    Directory of Open Access Journals (Sweden)

    Tanveer Ahmed


    Full Text Available This paper aims to address the question of offering a culturally adapted website for a local audience. So far, in the website design arena the vast majority of studies examined mainly Western and the American (low power distance and low context culture disregarding possible cultural discrepancies. This study fills this gap and explores the key cultural parameters that are likely to have an impact on local website design for Asian-Eastern culture high power distance and high context correlating with both Hofstede’s and Hall’s cultural dimensions. It also reviews how website localisation may be accomplished more effectively by extracting the guidelines from two different yet compatible cultural dimensions: high power distance and high context.

  1. High Accuracy, Miniature Pressure Sensor for Very High Temperatures Project (United States)

    National Aeronautics and Space Administration — SiWave proposes to develop a compact, low-cost MEMS-based pressure sensor for very high temperatures and low pressures in hypersonic wind tunnels. Most currently...

  2. High Voltage in Noble Liquids for High Energy Physics

    Energy Technology Data Exchange (ETDEWEB)

    Rebel, B. [Fermilab; Bernard, E. [Yale U.; Faham, C. H. [LBL, Berkeley; Ito, T. M. [Los Alamos; Lundberg, B. [Maryland U.; Messina, M. [Columbia U.; Monrabal, F. [Valencia U., IFIC; Pereverzev, S. P. [LLNL, Livermore; Resnati, F. [Zurich, ETH; Rowson, P. C. [SLAC; Soderberg, M. [Fermilab; Strauss, T. [Bern U.; Tomas, A. [Imperial Coll., London; Va' vra, J. [SLAC; Wang, H. [UCLA


    A workshop was held at Fermilab November 8-9, 2013 to discuss the challenges of using high voltage in noble liquids. The participants spanned the fields of neutrino, dark matter, and electric dipole moment physics. All presentations at the workshop were made in plenary sessions. This document summarizes the experiences and lessons learned from experiments in these fields at developing high voltage systems in noble liquids.

  3. High Speed and High Resolution Table-Top Nanoscale Imaging

    CERN Document Server

    Tadesse, G K; Demmler, S; HÄdrich, S; Wahyutama, I; Steinert, M; Spielmann, C; ZÜrch, M; TÜnnermann, A; Limpert, J; Rothhardt, J


    We present a table-top coherent diffraction imaging (CDI) experiment based on high-order harmonics generated at 18 nm by a high average power femtosecond fiber laser system. The high photon flux, narrow spectral bandwidth and high degree of spatial coherence allow for ultra-high sub-wavelength resolution imaging at a high numerical aperture. Our experiments demonstrate a half-pitch resolution of 13.6 nm, very close to the actual Abbe-limit of 12.4 nm, which is the highest resolution achieved from any table-top XUV or X-ray microscope. In addition, 20.5 nm resolution was achieved with only 3 sec of integration time bringing live diffraction imaging and 3D tomography on the nanoscale one step closer to reality. The current resolution is solely limited by the wavelength and the detector size. Thus, table-top nanoscopes with only a few-nm resolutions are in reach and will find applications in many areas of science and technology.

  4. Development of a high strength high toughness ausferritic steel

    Energy Technology Data Exchange (ETDEWEB)

    Putatunda, Susil K., E-mail: [Department of Chemical Engineering and Material Science, Wayne State University, 5050 Anthony Wayne Dr., Detroit, MI 48202 (United States); Singar, Arjun V. [Department of Chemical Engineering and Material Science, Wayne State University, 5050 Anthony Wayne Dr., Detroit, MI 48202 (United States); Tackett, Ronald; Lawes, Gavin [Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201 (United States)


    A new ausferritic steel with high strength and exceptionally high fracture toughness has been developed. This steel has been synthesized integrating concepts from Austempered Ductile Cast Iron (ADI) technology. The influence of the austempering temperature on the microstructure and mechanical properties of this steel at room temperature and ambient atmosphere has been examined. The effect of microstructure on the plane strain fracture toughness and on the magnetic, electrical, and thermal properties was also investigated. Compact tension and cylindrical tensile specimens prepared from the low alloy medium carbon steel with high silicon content were initially austenitized at 927 deg. C for 2 h and then subsequently austempered at several temperatures between 260 deg. C (500 F) and 400 deg. C (750 F) to produce different microstructures. The microstructures were characterized by X-ray diffraction, scanning electron microscopy and optical metallography. A combination of exceptionally high yield strength (1336 MPa) and a high fracture of toughness of 116 MPa{radical}m (a value comparable to maraging steel) was obtained in this steel after austempering at 316 deg. C (600 F) for 2 h. Potential applications of this steel include the inexpensive fabrication of armored plates and components requiring high reliability and durability.

  5. High-Power, High-Thrust Ion Thruster (HPHTion) (United States)

    Peterson, Peter Y.


    Advances in high-power photovoltaic technology have enabled the possibility of reasonably sized, high-specific power solar arrays. At high specific powers, power levels ranging from 50 to several hundred kilowatts are feasible. Ion thrusters offer long life and overall high efficiency (typically greater than 70 percent efficiency). In Phase I, the team at ElectroDynamic Applications, Inc., built a 25-kW, 50-cm ion thruster discharge chamber and fabricated a laboratory model. This was in response to the need for a single, high-powered engine to fill the gulf between the 7-kW NASA's Evolutionary Xenon Thruster (NEXT) system and a notional 25-kW engine. The Phase II project matured the laboratory model into a protoengineering model ion thruster. This involved the evolution of the discharge chamber to a high-performance thruster by performance testing and characterization via simulated and full beam extraction testing. Through such testing, the team optimized the design and built a protoengineering model thruster. Coupled with gridded ion thruster technology, this technology can enable a wide range of missions, including ambitious near-Earth NASA missions, Department of Defense missions, and commercial satellite activities.

  6. High harmonic fast waves in high beta plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Ono, Masayuki


    High harmonic fast magnetosonic wave in high beta/high dielectric plasmas is investigated. including the finite-Larmor-radius effects. In this regime, due to the combination of group velocity slow down and the high beta enhancement, the electron absorption via electron Landau and electron magnetic pumping becomes significant enough that one can expect a strong ({approximately} 100%) single pass absorption. By controlling the wave spectrum, the prospect of some localized electron heating and current drive appears to be feasible in high beta low-aspect-ratio tokamak regimes. Inclusion of finite-Larmor-radius terms shows an accessibility limit in the high ion beta regime ({beta}{sub i} = 50% for a deuterium plasma) due to mode-conversion into an ion Bernstein-wave-like mode while no beta limit is expected for electrons. With increasing ion beta, the ion damping can increase significantly particularly near the beta limits. The presence of energetic ion component expected during intense NBI and {alpha}-heating does not appear to modify the accessibility condition nor cause excessive wave absorption.

  7. Design optimization of high pressure and high temperature piezoresistive pressure sensor for high sensitivity (United States)

    Niu, Zhe; Zhao, Yulong; Tian, Bian


    This paper describes a design method for optimizing sensitivity of piezoresistive pressure sensor in high-pressure and high-temperature environment. In order to prove the method, a piezoresistive pressure sensor (HPTSS) is designed. With the purpose of increasing sensitivity and to improve the measurement range, the piezoresistive sensor adopts rectangular membrane and thick film structure. The configuration of piezoresistors is arranged according to the characteristic of the rectangular membrane. The structure and configuration of the sensor chip are analyzed theoretically and simulated by the finite element method. This design enables the sensor chip to operate in high pressure condition (such as 150 MPa) with a high sensitivity and accuracy. The silicon on insulator wafer is selected to guarantee the thermo stability of the sensor chip. In order to optimize the fabrication and improve the yield of production, an electric conduction step is devised. Series of experiments demonstrates a favorable linearity of 0.13% and a high accuracy of 0.48%. And the sensitivity of HTPSS is about six times as high as a conventional square-membrane sensor chip in the experiment. Compared with the square-membrane pressure sensor and current production, the strength of HPTTS lies in sensitivity and measurement. The performance of the HPTSS indicates that it could be an ideal candidate for high-pressure and high-temperature sensing in real application.

  8. Design optimization of high pressure and high temperature piezoresistive pressure sensor for high sensitivity. (United States)

    Niu, Zhe; Zhao, Yulong; Tian, Bian


    This paper describes a design method for optimizing sensitivity of piezoresistive pressure sensor in high-pressure and high-temperature environment. In order to prove the method, a piezoresistive pressure sensor (HPTSS) is designed. With the purpose of increasing sensitivity and to improve the measurement range, the piezoresistive sensor adopts rectangular membrane and thick film structure. The configuration of piezoresistors is arranged according to the characteristic of the rectangular membrane. The structure and configuration of the sensor chip are analyzed theoretically and simulated by the finite element method. This design enables the sensor chip to operate in high pressure condition (such as 150 MPa) with a high sensitivity and accuracy. The silicon on insulator wafer is selected to guarantee the thermo stability of the sensor chip. In order to optimize the fabrication and improve the yield of production, an electric conduction step is devised. Series of experiments demonstrates a favorable linearity of 0.13% and a high accuracy of 0.48%. And the sensitivity of HTPSS is about six times as high as a conventional square-membrane sensor chip in the experiment. Compared with the square-membrane pressure sensor and current production, the strength of HPTTS lies in sensitivity and measurement. The performance of the HPTSS indicates that it could be an ideal candidate for high-pressure and high-temperature sensing in real application.

  9. Survey of Processing Methods for High Strength High Conductivity Wires for High Field Magnet Applications

    Energy Technology Data Exchange (ETDEWEB)

    Han, K.; Embury, J.D.


    This paper will deal with the basic concepts of attaining combination of high strength and high conductivity in pure materials, in-situ composites and macrocomposites. It will survey current attainments, and outline where some future developments may lie in developing wire products that are close to the theoretical strength of future magnet applications.

  10. High-frequency magnetic components

    CERN Document Server

    Kazimierczuk, Marian K


    If you are looking for a complete study of the fundamental concepts in magnetic theory, read this book. No other textbook covers magnetic components of inductors and transformers for high-frequency applications in detail. This unique text examines design techniques of the major types of inductors and transformers used for a wide variety of high-frequency applications including switching-mode power supplies (SMPS) and resonant circuits. It describes skin effect and proximity effect in detail to provide you with a sound understanding of high-frequency phenomena. As well as this, you will disco

  11. High Scalability Video ISR Exploitation (United States)


    Surveillance, ARGUS) on the National Image Interpretability Rating Scale (NIIRS) at level 6. Ultra-high quality cameras like the Digital Cinema 4K (DC-4K...Scale (NIIRS) at level 6. Ultra-high quality cameras like the Digital Cinema 4K (DC-4K), which recognizes objects smaller than people, will be available...purchase ultra-high quality cameras like the Digital Cinema 4K (DC-4K) for use in the field. However, even if such a UAV sensor with a DC-4K was flown

  12. Conference on High Energy Physics

    CERN Document Server


    Conference on High Energy Physics (HEP 2016) will be held from August 24 to 26, 2016 in Xi'an, China. This Conference will cover issues on High Energy Physics. It dedicates to creating a stage for exchanging the latest research results and sharing the advanced research methods. HEP 2016 will be an important platform for inspiring international and interdisciplinary exchange at the forefront of High Energy Physics. The Conference will bring together researchers, engineers, technicians and academicians from all over the world, and we cordially invite you to take this opportunity to join us for academic exchange and visit the ancient city of Xi’an.

  13. High-speed photonics interconnects

    CERN Document Server

    Chrostowski, Lukas


    Dramatic increases in processing power have rapidly scaled on-chip aggregate bandwidths into the Tb/s range. This necessitates a corresponding increase in the amount of data communicated between chips, so as not to limit overall system performance. To meet the increasing demand for interchip communication bandwidth, researchers are investigating the use of high-speed optical interconnect architectures. Unlike their electrical counterparts, optical interconnects offer high bandwidth and negligible frequency-dependent loss, making possible per-channel data rates of more than 10 Gb/s. High-Speed

  14. Understanding high-dimensional spaces

    CERN Document Server

    Skillicorn, David B


    High-dimensional spaces arise as a way of modelling datasets with many attributes. Such a dataset can be directly represented in a space spanned by its attributes, with each record represented as a point in the space with its position depending on its attribute values. Such spaces are not easy to work with because of their high dimensionality: our intuition about space is not reliable, and measures such as distance do not provide as clear information as we might expect. There are three main areas where complex high dimensionality and large datasets arise naturally: data collected by online ret

  15. High-Pressure Vibrational Spectroscopy. (United States)

    Pogson, Mark


    Available from UMI in association with The British Library. Requires signed TDF. The study of solids at high pressure and variable temperature enables development of accurate interatomic potential functions over wide ranges of interatomic distances. A review of the main models used in the determination of these potentials is given in Chapter one. A discussion of phonon frequency as a variable physical parameter reflecting the interatomic potential is given. A high pressure Raman study of inorganic salts of the types MSCN, (M = K,Rb,Cs & NH_4^+ ) and MNO_2, (M = K,Na) has been completed. The studies have revealed two new phases in KNO_2 and one new phase in NaNO _2 at high pressure. The accurate phonon shift data have enabled the determination of the pure and biphasic stability regions of the phases of KNO _2. A discussion of the B1, B2 relationship of univalent nitrites is also given. In the series of thiocyanates studied new phases have been found in all four materials. In both the potassium and rubidium salts two new phases have been detected, and in the ceasium salt one new phase has been detected, all at high pressure, from accurate phonon shift data. These transitions are discussed in terms of second-order mechanisms with space groups suggested for all phases, based on Landau's theory of second-order phase transitions. In the ammonium salt one new phase has been detected. This new phase transition has been interpreted as a second-order transition. The series of molecular crystals CH_3 HgX, (X = Cl,Br & I) has been studied at high pressure and at variable temperature. In Chapter five, their phase behaviour at high pressure is detailed along with the pressure dependencies of their phonon frequencies. In the chloride and the bromide two new phases have been detected. In the bromide one has been detected at high temperature and one at high pressure, and latter being interpreted as the stopping of the methyl rotation. In the chloride one phase has been found at

  16. Raman Spectroscopy at High Pressures

    Directory of Open Access Journals (Sweden)

    Alexander F. Goncharov


    Full Text Available Raman spectroscopy is one of the most informative probes for studies of material properties under extreme conditions of high pressure. The Raman techniques have become more versatile over the last decades as a new generation of optical filters and multichannel detectors become available. Here, recent progress in the Raman techniques for high-pressure research and its applications in numerous scientific disciplines including physics and chemistry of materials under extremes, earth and planetary science, new materials synthesis, and high-pressure metrology will be discussed.

  17. High Tech M&As

    DEFF Research Database (Denmark)

    Toppenberg, Gustav


    of findings are not applicable to the high-tech industry; in fact this industry has many additional challenges. In this study, we aim to explore the process of M&A in the high-tech industry by drawing on extant literature and empirical field work. The paper outlines a research project in progress which...... intends to provide theoretical, empirical and practical contributions in answering the research question: what role does Operations and IT play in creating value in high-tech M&As? The research adds a needed perspective on M&A literature by unveiling unique challenges and opportunities faced by the M...

  18. Arterial occlusion precipitated by cisplatinbased chemotherapy



    Cisplatin-based therapy is curative in testicular cancer. Adverse effects of cisplatin-based chemotherapy include dose-dependent myelosuppression, nephrotoxicity, neurotoxicity, and ototoxicity. By contrast, chemotherapy-associated vascular complications are unpredictable. Few incidents of digital gangrene with cisplatin have been reported. Here, we present a patient who developed arterial occlusion leading to gangrene of the toe after cisplatinbased chemotherapy.

  19. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... readings. Blood Pressure Severity and Type Your health care provider usually takes 2–3 readings at several medical appointments to diagnose high blood pressure. Using the ...

  20. High density matter at RHIC

    Indian Academy of Sciences (India)

    Thomas S Ullrich


    QCD predicts a phase transition between hadronic matter and a quark-gluon plasma at high energy density. The relativistic heavy ion collider (RHIC) at Brookhaven National Laboratory is a new facility dedicated to the experimental study of matter under extreme conditions. Already the first round of experimental results at RHIC indicated that the conditions to create a new state of matter are indeed reached in the collisions of heavy nuclei. Studies of particle spectra and their correlations at low transverse momenta provide evidence of strong pressure gradients in the highly interacting dense medium and hint that we observe a system in thermal equilibrium. Recent runs with high statistics allow us to explore the regime of hard-scattering processes where the suppression of hadrons at large transverse momentum, and quenching of di-jets are observed thus providing further evidence for extreme high density matter created in collisions at RHIC.

  1. What Causes High Blood Cholesterol? (United States)

    ... the NHLBI on Twitter. What Causes High Blood Cholesterol? Many factors can affect the cholesterol levels in your blood. You can control some ... but not others. Factors You Can Control Diet Cholesterol is found in foods that come from animal ...

  2. High dynamic range subjective testing (United States)

    Allan, Brahim; Nilsson, Mike


    This paper describes of a set of subjective tests that the authors have carried out to assess the end user perception of video encoded with High Dynamic Range technology when viewed in a typical home environment. Viewers scored individual single clips of content, presented in High Definition (HD) and Ultra High Definition (UHD), in Standard Dynamic Range (SDR), and in High Dynamic Range (HDR) using both the Perceptual Quantizer (PQ) and Hybrid Log Gamma (HLG) transfer characteristics, and presented in SDR as the backwards compatible rendering of the HLG representation. The quality of SDR HD was improved by approximately equal amounts by either increasing the dynamic range or increasing the resolution to UHD. A further smaller increase in quality was observed in the Mean Opinion Scores of the viewers by increasing both the dynamic range and the resolution, but this was not quite statistically significant.

  3. High Blood Pressure in Pregnancy (United States)

    ... of the baby. Controlling your blood pressure during pregnancy and getting regular prenatal care are important for ... your baby. Treatments for high blood pressure in pregnancy may include close monitoring of the baby, lifestyle ...

  4. High Temperature Materials Laboratory (HTML) (United States)

    Federal Laboratory Consortium — The six user centers in the High Temperature Materials Laboratory (HTML), a DOE User Facility, are dedicated to solving materials problems that limit the efficiency...

  5. High Temperature Bell Motor Project (United States)

    National Aeronautics and Space Administration — The National Research Council (NRC) has identified the need for motors and actuators that can operate in extreme high and low temperature environments as a technical...

  6. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... ask for your readings. Blood Pressure Severity and Type Your health care provider usually takes 2–3 ... any other location. Health care providers diagnose this type of high blood pressure by reviewing readings in ...

  7. Gallium phosphide high temperature diodes (United States)

    Chaffin, R. J.; Dawson, L. R.


    High temperature (300 C) diodes for geothermal and other energy applications were developed. A comparison of reverse leakage currents of Si, GaAs, and GaP was made. Diodes made from GaP should be usable to 500 C. A Liquid Phase Epitaxy (LPE) process for producing high quality, grown junction GaP diodes is described. This process uses low vapor pressure Mg as a dopant which allows multiple boat growth in the same LPE run. These LPE wafers were cut into die and metallized to make the diodes. These diodes produce leakage currents below ten to the -9th power A/sq cm at 400 C while exhibiting good high temperature rectification characteristics. High temperature life test data is presented which shows exceptional stability of the V-I characteristics.

  8. High Energy Density Capacitors Project (United States)

    National Aeronautics and Space Administration — Capacitor size and reliability are often limiting factors in pulse power, high speed switching, and power management and distribution (PMAD) systems. T/J...

  9. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... and Obesity Smoking and Your Heart Stroke Send a link to NHLBI to someone by E-MAIL | ... 90 mmHg or above. Confirming High Blood Pressure A blood pressure test is easy and painless and ...

  10. High ability: Giftedness and talent

    Directory of Open Access Journals (Sweden)

    María Dolores Prieto Sánchez


    Full Text Available This special issue of the journal aims at putting together national and international research on high abilities, and is divided into three sections: 1 Roles and cognitive, emotional and professional competences of high ability students’ teachers, 2 Identification and assessment of high ability students, 3 Analysis of practices, programs and mentoring of high ability students’ attention to diversity.The articles are authored by scholars from nine different countries (Spain, Argentina, UK, USA, Russia, Brazil, Saudi Arabia, Portugal and Poland, from sixteen different Spanish and international universities: Alicante (Spain, Autónoma de Barcelona (Spain, Málaga (Spain, Murcia (Spain, Navarra (Spain, Oviedo (Spain, Tufts University (USA, Yale University (USA, Moscow State University (Russia, Nacional de La Plata (Argentina, University of Connecticut (USA, Universidade do Minho (Portugal, Universidade da Beira Interior (Portugal, Universidade do Estado do Rio de Janeiro (Brazil, King Faisal University (Saudi Arabia and Universidad de Szczecin (Poland.

  11. Sleep in High Stress Occupations (United States)

    Flynn-Evans, Erin


    High stress occupations are associated with sleep restriction, circadian misalignment and demanding workload. This presentation will provide an overview of sleep duration, circadian misalignment and fatigue countermeasures and performance outcomes during spaceflight and commercial aviation.

  12. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... above. Confirming High Blood Pressure A blood pressure test is easy and painless and can be done ... provider’s office or clinic. To prepare for the test: Don’t drink coffee or smoke cigarettes for ...

  13. High Power Betavoltaic Technology Project (United States)

    National Aeronautics and Space Administration — The proposed innovation will dramatically improve the performance of tritium-powered betavoltaic batteries through the development of a high-aspect ratio, expanded...

  14. SEDflume - High Shear Stress Flume (United States)

    Federal Laboratory Consortium — The U.S. Army Corps of Engineers High Shear Stress flume (SEDflume) is designed for estimating erosion rates of fine-grained and mixed fine/coarse grained sediments...

  15. Geographies of High Frequency Trading

    DEFF Research Database (Denmark)

    Grindsted, Thomas Skou


    This paper investigates the geographies of high frequency trading. Today shares shift hands within micro seconds, giving rise to a form of financial geographies termed algorithmic capitalism. This notion refers to the different spatio-temporalities produced by high frequency trading, under...... the valuation of time. As high frequency trading accelerates financial markets, the paper examines the spatio-temporalities of automated trading by the ways in which the speed of knowledge exploitation in financial markets is not only of interest, but also the expansion between different temporalities....... The paper demonstrates how the intensification of time-space compression produces radical new dynamics in the financial market and develops information rent in HFT as convertible to a time rent and a spatio-temporal rent. The final section discusses whether high frequency trading only responds to crises...

  16. High pressure rinsing parameters measurements

    Energy Technology Data Exchange (ETDEWEB)

    Cavaliere, E. [INFN Milano - LASA, Via F.lli Cervi 201, I-20090 Segrate (MI) (Italy); Fusetti, M. [INFN Milano - LASA, Via F.lli Cervi 201, I-20090 Segrate (MI) (Italy); Michelato, P. [INFN Milano - LASA, Via F.lli Cervi 201, I-20090 Segrate (MI) (Italy); Pagani, C. [INFN Milano - LASA, Via F.lli Cervi 201, I-20090 Segrate (MI) (Italy)]. E-mail:; Pierini, P. [INFN Milano - LASA, Via F.lli Cervi 201, I-20090 Segrate (MI) (Italy); Paulon, R. [INFN Milano - LASA, Via F.lli Cervi 201, I-20090 Segrate (MI) (Italy); Sertore, D. [INFN Milano - LASA, Via F.lli Cervi 201, I-20090 Segrate (MI) (Italy)


    High pressure rinsing with ultra pure water jet is an essential step in the high field superconducting cavity production process. In this paper, we illustrate the experimental characterization of a HPR system, in terms of specific power and energy deposition on the cavity surfaces and on the damage threshold for niobium. These measurements are used to tentatively derive general rules for the optimization of the free process parameters (nozzle geometry, speeds and water pressure)

  17. High pressure rinsing system comparison

    Energy Technology Data Exchange (ETDEWEB)

    D. Sertore; M. Fusetti; P. Michelato; Carlo Pagani; Toshiyasu Higo; Jin-Seok Hong; K. Saito; G. Ciovati; T. Rothgeb


    High pressure rinsing (HPR) is a key process for the surface preparation of high field superconducting cavities. A portable apparatus for the water jet characterization, based on the transferred momentum between the water jet and a load cell, has been used in different laboratories. This apparatus allows to collected quantitative parameters that characterize the HPR water jet. In this paper, we present a quantitative comparison of the different water jet produced by various nozzles routinely used in different laboratories for the HPR process

  18. RavenDB high performance

    CERN Document Server

    Ritchie, Brian


    RavenDB High Performance is comprehensive yet concise tutorial that developers can use to.This book is for developers & software architects who are designing systems in order to achieve high performance right from the start. A basic understanding of RavenDB is recommended, but not required. While the book focuses on advanced topics, it does not assume that the reader has a great deal of prior knowledge of working with RavenDB.

  19. High division of sciatic nerve

    Directory of Open Access Journals (Sweden)

    Tripti Shrivastava


    Results: In all except two cadavers, the nerve divided at the apex of the popliteal fossa. In two cadavers the sciatic nerve divided bilaterally in the upper part of thigh. Conclusion: The high division presented in this study can make popliteal nerve blocks partially ineffective. The high division of sciatic nerve must always be borne in mind as they have important clinical implications. [Int J Res Med Sci 2014; 2(2.000: 686-688

  20. The AAVSO High Energy Network (United States)

    Price, Aaron


    The AAVSO is expanding its International Gamma-Ray Burst Network to incorporate other high energy objects such as blazars and magnetic cataclysmic variables (polars). The new AAVSO High Energy Network will be collaborating with the Global Telescope Network (GTN) to observe bright blazars in support of the upcoming GLAST mission. We also will be observing polars in support of the XMM mission. This new network will involve both visual and CCD obsrvers and is expected to last for many years.

  1. Ultra High Energy Nuclei Propagation

    CERN Document Server

    Aloisio, Roberto


    We discuss the problem of ultra high energy nuclei propagation in astrophysical backgrounds. We present a new analytical computation scheme based on the hypothesis of continuos energy losses in a kinetic formulation of the particles propagation. This scheme enables the computation of the fluxes of ultra high energy nuclei as well as the fluxes of secondaries (nuclei and nucleons) produced by the process of photo-disintegration suffered by nuclei.

  2. Multicomponent and High Entropy Alloys

    Directory of Open Access Journals (Sweden)

    Brian Cantor


    Full Text Available This paper describes some underlying principles of multicomponent and high entropy alloys, and gives some examples of these materials. Different types of multicomponent alloy and different methods of accessing multicomponent phase space are discussed. The alloys were manufactured by conventional and high speed solidification techniques, and their macroscopic, microscopic and nanoscale structures were studied by optical, X-ray and electron microscope methods. They exhibit a variety of amorphous, quasicrystalline, dendritic and eutectic structures.

  3. Very high redshift radio galaxies

    Energy Technology Data Exchange (ETDEWEB)

    van Breugel, W.J.M., LLNL


    High redshift radio galaxies (HzRGs) provide unique targets for the study of the formation and evolution of massive galaxies and galaxy clusters at very high redshifts. We discuss how efficient HzRG samples ae selected, the evidence for strong morphological evolution at near-infracd wavelengths, and for jet-induced star formation in the z = 3 800 HzRG 4C41 17

  4. MongoDB high availability

    CERN Document Server

    Mehrabani, Afshin


    This book has a perfect balance of concepts and their practical implementation along with solutions to make a highly available MongoDB server with clear instructions and guidance. If you are using MongoDB in a production environment and need a solution to make a highly available MongoDB server, this book is ideal for you. Familiarity with MongoDB is expected so that you understand the content of this book.

  5. Future High Capacity Backbone Networks

    DEFF Research Database (Denmark)

    Wang, Jiayuan

    This thesis - Future High Capacity Backbone Networks - deals with the energy efficiency problems associated with the development of future optical networks. In the first half of the thesis, novel approaches for using multiple/single alternative energy sources for improving energy efficiency...... the context of the integrated control plane structure. Results show improvements of energy efficiency over three types of traffic, while still keeping acceptable QoS levels for high priority traffic....

  6. High power, high efficiency millimeter wavelength traveling wave tubes for high rate communications from deep space (United States)

    Dayton, James A., Jr.


    The high-power transmitters needed for high data rate communications from deep space will require a new class of compact, high efficiency traveling wave tubes (TWT's). Many of the recent TWT developments in the microwave frequency range are generically applicable to mm wave devices, in particular much of the technology of computer aided design, cathodes, and multistage depressed collectors. However, because TWT dimensions scale approximately with wavelength, mm wave devices will be physically much smaller with inherently more stringent fabrication tolerances and sensitivity to thermal dissipation.

  7. Discovering highly informative feature set over high dimensions

    KAUST Repository

    Zhang, Chongsheng


    For many textual collections, the number of features is often overly large. These features can be very redundant, it is therefore desirable to have a small, succinct, yet highly informative collection of features that describes the key characteristics of a dataset. Information theory is one such tool for us to obtain this feature collection. With this paper, we mainly contribute to the improvement of efficiency for the process of selecting the most informative feature set over high-dimensional unlabeled data. We propose a heuristic theory for informative feature set selection from high dimensional data. Moreover, we design data structures that enable us to compute the entropies of the candidate feature sets efficiently. We also develop a simple pruning strategy that eliminates the hopeless candidates at each forward selection step. We test our method through experiments on real-world data sets, showing that our proposal is very efficient. © 2012 IEEE.

  8. Note: High precision measurements using high frequency gigahertz signals (United States)

    Jin, Aohan; Fu, Siyuan; Sakurai, Atsunori; Liu, Liang; Edman, Fredrik; Pullerits, Tõnu; Öwall, Viktor; Karki, Khadga Jung


    Generalized lock-in amplifiers use digital cavities with Q-factors as high as 5 × 108 to measure signals with very high precision. In this Note, we show that generalized lock-in amplifiers can be used to analyze microwave (giga-hertz) signals with a precision of few tens of hertz. We propose that the physical changes in the medium of propagation can be measured precisely by the ultra-high precision measurement of the signal. We provide evidence to our proposition by verifying the Newton's law of cooling by measuring the effect of change in temperature on the phase and amplitude of the signals propagating through two calibrated cables. The technique could be used to precisely measure different physical properties of the propagation medium, for example, the change in length, resistance, etc. Real time implementation of the technique can open up new methodologies of in situ virtual metrology in material design.

  9. Performance evaluation of high speed compressors for high speed multipliers

    Directory of Open Access Journals (Sweden)

    Nirlakalla Ravi


    Full Text Available This paper describes high speed compressors for high speed parallel multipliers like Booth Multiplier, Wallace Tree Multiplier in Digital Signal Processing (DSP. This paper presents 4-3, 5-3, 6-3 and 7-3 compressors for high speed multiplication. These compressors reduce vertical critical path more rapidly than conventional compressors. A 5-3 conventional compressor can take four steps to reduce bits from 5 to 3, but the proposed 5-3 takes only 2 steps. These compressors are simulated with H-Spice at a temperature of 25°C at a supply voltage 2.0V using 90nm MOSIS technology. The Power, Delay, Power Delay Product (PDP and Energy Delay Product (EDP of the compressors are calculated to analyze the total propagation delay and energy consumption. All the compressors are designed with half adder and full Adders only.

  10. High point for CERN and high-temperature superconductors

    CERN Multimedia


    Amalia Ballarino is named the Superconductor Industry Person of the year 2006. Amalia Ballarino showing a tape of high-superconducting material used for the LHC current leads.The CERN project leader for the high-temperature superconducting current leads for the LHC, Amalia Ballarino, has received the award for "Superconductor Industry Person of the Year". This award, the most prestigious international award in the development and commercialization of superconductors, is presented by the leading industry newsletter "Superconductor Week". Amalia Ballarino was selected from dozens of nominations from around the world by a panel of recognized leading experts in superconductivity. "It is a great honour for me," says Amalia Ballarino. "It has been many years of hard work, and it’s a great satisfaction to see that the work has been completed successfully." Amalia Ballarino has been working on high-temperature superconducting materials sin...

  11. High Temperature Oxidation and Corrosion Properties of High Entropy Superalloys

    Directory of Open Access Journals (Sweden)

    Te-Kang Tsao


    Full Text Available The present work investigates the high temperature oxidation and corrosion behaviour of high entropy superalloys (HESA. A high content of various solutes in HESA leads to formation of complex oxides, however the Cr and Al activities of HESA are sufficient to promote protective chromia or alumina formation on the surface. By comparing the oxidation and corrosion resistances of a Ni-based superalloy—CM247LC, Al2O3-forming HESA can possess comparable oxidation resistance at 1100 °C, and Cr2O3-forming HESA can exhibit superior resistance against hot corrosion at 900 °C. This work has demonstrated the potential of HESA to maintain surface stability in oxidizing and corrosive environments.

  12. High-Entropy Metallic Glasses (United States)

    Wang, W. H.


    The high-entropy alloys are defined as solid-solution alloys containing five or more than five principal elements in equal or near-equal atomic percent. The concept of high mixing entropy introduces a new way for developing advanced metallic materials with unique physical and mechanical properties that cannot be achieved by the conventional microalloying approach based on only a single base element. The metallic glass (MG) is the metallic alloy rapidly quenched from the liquid state, and at room temperature it still shows an amorphous liquid-like structure. Bulk MGs represent a particular class of amorphous alloys usually with three or more than three components but based on a single principal element such as Zr, Cu, Ce, and Fe. These materials are very attractive for applications because of their excellent mechanical properties such as ultrahigh (near theoretical) strength, wear resistance, and hardness, and physical properties such as soft magnetic properties. In this article, we review the formation and properties of a series of high-mixing-entropy bulk MGs based on multiple major elements. It is found that the strategy and route for development of the high-entropy alloys can be applied to the development of the MGs with excellent glass-forming ability. The high-mixing-entropy bulk MGs are then loosely defined as metallic glassy alloys containing five or more than five elements in equal or near-equal atomic percent, which have relatively high mixing entropy compared with the conventional MGs based on a single principal element. The formation mechanism, especially the role of the mixing entropy in the formation of the high-entropy MGs, is discussed. The unique physical, mechanical, chemical, and biomedical properties of the high-entropy MGs in comparison with the conventional metallic alloys are introduced. We show that the high-mixing-entropy MGs, along the formation idea and strategy of the high-entropy alloys and based on multiple major elements, might provide

  13. High-pressure-high-temperature treatment of natural diamonds

    CERN Document Server

    Royen, J V


    The results are reported of high-pressure-high-temperature (HPHT) treatment experiments on natural diamonds of different origins and with different impurity contents. The diamonds are annealed in a temperature range up to 2000 sup o C at stabilizing pressures up to 7 GPa. The evolution is studied of different defects in the diamond crystal lattice. The influence of substitutional nitrogen atoms, plastic deformation and the combination of these is discussed. Diamonds are characterized at room and liquid nitrogen temperature using UV-visible spectrophotometry, Fourier transform infrared spectrophotometry and photoluminescence spectrometry. The economic implications of diamond HPHT treatments are discussed.

  14. LHDAC setup for high temperature and high pressure studies

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Nishant N., E-mail:; Meenakshi, S., E-mail:; Sharma, Surinder M., E-mail: [High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai-400085 (India)


    A ytterbium fibre laser (λ = 1.07 μm) based laser heated diamond anvil cell (LHDAC) facility has been recently set up at HP and SRPD, BARC for simultaneous high temperature and high pressure investigation of material properties. Synthesis of GaN was carried out at pressure of ∼9 GPa and temperature of ∼1925 K in a Mao-Bell type diamond anvil cell (DAC) using the LHDAC facility. The retrieved sample has been characterized using our laboratory based micro Raman setup.

  15. High bandgap III-V alloys for high efficiency optoelectronics

    Energy Technology Data Exchange (ETDEWEB)

    Alberi, Kirstin; Mascarenhas, Angelo; Wanlass, Mark


    High bandgap alloys for high efficiency optoelectronics are disclosed. An exemplary optoelectronic device may include a substrate, at least one Al.sub.1-xIn.sub.xP layer, and a step-grade buffer between the substrate and at least one Al.sub.1-xIn.sub.xP layer. The buffer may begin with a layer that is substantially lattice matched to GaAs, and may then incrementally increase the lattice constant in each sequential layer until a predetermined lattice constant of Al.sub.1-xIn.sub.xP is reached.

  16. High-Temperature-High-Volume Lifting for Enhanced Geothermal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Turnquist, Norman [GE Global Research, Munchen (Germany); Qi, Xuele [GE Global Research, Munchen (Germany); Raminosoa, Tsarafidy [GE Global Research, Munchen (Germany); Salas, Ken [GE Global Research, Munchen (Germany); Samudrala, Omprakash [GE Global Research, Munchen (Germany); Shah, Manoj [GE Global Research, Munchen (Germany); Van Dam, Jeremy [GE Global Research, Munchen (Germany); Yin, Weijun [GE Global Research, Munchen (Germany); Zia, Jalal [GE Global Research, Munchen (Germany)


    This report summarizes the progress made during the April 01, 2010 – December 30, 2013 period under Cooperative Agreement DE-EE0002752 for the U.S. Department of Energy entitled “High-Temperature-High-Volume Lifting for Enhanced Geothermal Systems.” The overall objective of this program is to advance the technology for well fluids lifting systems to meet the foreseeable pressure, temperature, and longevity needs of the Enhanced Geothermal Systems (EGS) industry for the coming ten years. In this program, lifting system requirements for EGS wells were established via consultation with industry experts and site visits. A number of artificial lift technologies were evaluated with regard to their applicability to EGS applications; it was determined that a system based on electric submersible pump (ESP) technology was best suited to EGS. Technical barriers were identified and a component-level technology development program was undertaken to address each barrier, with the most challenging being the development of a power-dense, small diameter motor that can operate reliably in a 300°C environment for up to three years. Some of the targeted individual component technologies include permanent magnet motor construction, high-temperature insulation, dielectrics, bearings, seals, thrust washers, and pump impellers/diffusers. Advances were also made in thermal management of electric motors. In addition to the overall system design for a full-scale EGS application, a subscale prototype was designed and fabricated. Like the full-scale design, the subscale prototype features a novel “flow-through-the-bore” permanent magnet electric motor that combines the use of high temperature materials with an internal cooling scheme that limits peak internal temperatures to <330°C. While the full-scale high-volume multi-stage pump is designed to lift up to 80 kg/s of process water, the subscale prototype is based on a production design that can pump 20 kg/s and has been modified

  17. Mechanically Alloyed High Entropy Composite (United States)

    Popescu, G.; Adrian, M. M.; Csaki, I.; Popescu, C. A.; Mitrică, D.; Vasile, S.; Carcea, I.


    In the last years high entropy alloys have been investigated due to their high hardness, high temperature stability and unusual properties that make these alloys to have significant interest. In comparison with traditional alloys that are based on two or three major elements, this new generation alloys consists at least of 5 principal elements, with the concentration between 5 and 35 at.%. The present paper reports synthesis of high entropy alloys (HEA) and high entropy composites (HEC) synthesized by mechanical alloying (MA). The equiatomic AlCrFeNiMn matrix was used for creating the HEA matrix, starting from elemental powders and as reinforcing material for composites was used pure graphite. The mechanical alloying process was carried out at different duration, in a high energy planetary ball mill, under argon atmosphere. The elemental powders alloying began after '5 hours of milling and was complete after 40 hours. The mechanical alloyed matrix and composite was pressed and heat treated under argon protection. The elemental powers were investigated for physical - technological properties, and by X-ray diffraction and scanning electron microscopy. Phase pressing operation was realized with a hydraulic press and the applied pressure was progressive. The sintering process was carried out at 850°C for 2 h. The X-ray diffraction revealed that the MA process resulted in solid solutions formation and also revealed body- centred cubic (BCC) and face-centred cubic (FCC) structures with average grain size around 40 nm. In addition, nanoscale particles were highlighted by scanning electron microscopy, as well as the homogeneity of the chemical composition of the matrix and composite that was confirmed by EDX microanalysis. It was noted that HEA matrix and HEA composites were processed with a high degree of compaction and with a quite large capacity of mixed powder densification (around 70%).

  18. High Temperature Radio Frequency Loads

    CERN Document Server

    Federmann, S; Grudiev, A; Montesinos, E; Syratchev, I


    In the context of energy saving and recovery requirements the design of reliable and robust RF power loads which permit a high outlet temperature and high pressure of the cooling water is desirable. Cooling water arriving at the outlet withmore than 150 ◦C and high pressure has a higher value than water with 50 ◦C under low pressure. Conventional RF power loads containing dielectric and magnetic materials as well as sensitive ceramic windows usually do not permit going much higher than 90 ◦C. Here we present and discuss several design concepts for "metal only" RF high power loads. One concept is the application of magnetic steel corrugated waveguides near cutoff – this concept could find practical use above several GHz. Another solution are resonant structures made of steel to be installed in large waveguides for frequencies of 500 MHz or lower. Similar resonant structures above 100 MHz taking advantage of the rather high losses of normal steel may also be used in coaxial line geometries with large di...

  19. High-energy astroparticle physics

    CERN Document Server

    Semikoz, A


    In these three lectures I discuss the present status of high-energy astroparticle physics including Ultra-High-Energy Cosmic Rays (UHECR), high-energy gamma rays, and neutrinos. The first lecture is devoted to ultra-high-energy cosmic rays. After a brief introduction to UHECR I discuss the acceleration of charged particles to highest energies in the astrophysical objects, their propagation in the intergalactic space, recent observational results by the Auger and HiRes experiments, anisotropies of UHECR arrival directions, and secondary gamma rays produced by UHECR. In the second lecture I review recent results on TeV gamma rays. After a short introduction to detection techniques, I discuss recent exciting results of the H.E.S.S., MAGIC, and Milagro experiments on the point-like and diffuse sources of TeV gamma rays. A special section is devoted to the detection of extragalactic magnetic fields with TeV gammaray measurements. Finally, in the third lecture I discuss Ultra-High-Energy (UHE) neutrinos. I review t...

  20. Becoming a high reliability organization. (United States)

    Christianson, Marlys K; Sutcliffe, Kathleen M; Miller, Melissa A; Iwashyna, Theodore J


    Aircraft carriers, electrical power grids, and wildland firefighting, though seemingly different, are exemplars of high reliability organizations (HROs)--organizations that have the potential for catastrophic failure yet engage in nearly error-free performance. HROs commit to safety at the highest level and adopt a special approach to its pursuit. High reliability organizing has been studied and discussed for some time in other industries and is receiving increasing attention in health care, particularly in high-risk settings like the intensive care unit (ICU). The essence of high reliability organizing is a set of principles that enable organizations to focus attention on emergent problems and to deploy the right set of resources to address those problems. HROs behave in ways that sometimes seem counterintuitive--they do not try to hide failures but rather celebrate them as windows into the health of the system, they seek out problems, they avoid focusing on just one aspect of work and are able to see how all the parts of work fit together, they expect unexpected events and develop the capability to manage them, and they defer decision making to local frontline experts who are empowered to solve problems. Given the complexity of patient care in the ICU, the potential for medical error, and the particular sensitivity of critically ill patients to harm, high reliability organizing principles hold promise for improving ICU patient care.

  1. Credentialing high school psychology teachers. (United States)

    Weaver, Kenneth A


    The National Standards for High School Psychology Curricula (American Psychological Association, 2013b) require a teacher with considerable psychology content knowledge to teach high school psychology courses effectively. In this study, I examined the initial teaching credential requirements for high school psychology teachers in the 50 states plus the District of Columbia. Thirty-four states (the District of Columbia is included as a state) require the social studies credential to teach high school psychology. An analysis of the items on standardized tests used by states to validate the content knowledge required to teach social studies indicates little or no presence of psychology, a reflection of psychology's meager presence in the social studies teacher preparation curricula. Thus, new teachers with the social studies teaching credential are not prepared to teach high school psychology according to the National Standards. Approval of The College, Career, and Civic Life (C3) Framework for Social Studies State Standards: Guidance for Enhancing the Rigor of K-12 Civics, Economics, Geography, and History (National Council for the Social Studies, 2013) presents an opportunity to advocate for establishing a psychology credential in the 34 states.

  2. Compact high voltage, high peak power, high frequency transformer for converter type modulator applications. (United States)

    Reghu, T; Mandloi, V; Shrivastava, Purushottam


    The design and development of a compact high voltage, high peak power, high frequency transformer for a converter type modulator of klystron amplifiers is presented. The transformer has been designed to operate at a frequency of 20 kHz and at a flux swing of ±0.6 T. Iron (Fe) based nanocrystalline material has been selected as a core for the construction of the transformer. The transformer employs a specially designed solid Teflon bobbin having 120 kV insulation for winding the high voltage secondary windings. The flux swing of the core has been experimentally found by plotting the hysteresis loop at actual operating conditions. Based on the design, a prototype transformer has been built which is per se a unique combination of high voltage, high frequency, and peak power specifications. The transformer was able to provide 58 kV (pk-pk) at the secondary with a peak power handling capability of 700 kVA. The transformation ratio was 1:17. The performance of the transformer is also presented and discussed.

  3. High pressure study of high-temperature superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Souliou, Sofia-Michaela


    The current thesis studies experimentally the effect of high external pressure on high-T{sub c} superconductors. The structure and lattice dynamics of several members of the high-T{sub c} cuprate and Fe-based superconductors families were investigated by means of Raman spectroscopy and X-ray diffraction under well-controlled, hydrostatic high pressure and low temperature conditions. The lattice dynamics of the high-T{sub c} superconductor YBa{sub 2}Cu{sub 3}O{sub 6+x} have been investigated systematically by Raman spectroscopy as a function of doping (x = 0.95, 0.75, 0.60, 0.55, and 0.45) and external pressure. Under ambient pressure conditions, in addition to the Raman modes expected from group theory, we observe new Raman active phonons upon cooling the underdoped samples, at temperatures well above the superconducting transition temperature. The doping dependence and the onset temperatures of the new Raman features suggest that they are associated with the incommensurate charge density wave (CDW) state recently discovered in underdoped cuprates using synchrotron X-ray scattering techniques. Under high pressure conditions (from 2 to 12 GPa), our Raman measurements on highly ordered underdoped YBa{sub 2}Cu{sub 3}O{sub 6.55} samples do not show any of the new Raman phonons seen at ambient pressure. High pressure and low temperature Raman measurements have been performed on the underdoped superconductor YBa{sub 2}Cu{sub 4}O{sub 8}. A clear renormalization of some of the Raman phonons is seen below T{sub c} as a result of the changes in the phonon self-energy upon the opening of the superconducting gap, with the most prominent one being that of the B{sub 1g}-like buckling phonon mode. The amplitude of this renormalization strongly increases with pressure, resembling the effect of hole doping in YBa{sub 2}Cu{sub 3}O{sub 6+x}. At ∝ 10 GPa, the system undergoes a reversible pressure-induced structural phase transition to a non-centrosymmmetric structure (space group

  4. Transportable high-energy high-power generator. (United States)

    Novac, B M; Smith, I R; Senior, P; Parker, M; Louverdis, G


    High-power applications sometimes require a transportable, simple, and robust gigawatt pulsed power generator, and an analysis of various possible approaches shows that one based on a twin exploding wire array is extremely advantageous. A generator based on this technology and used with a high-energy capacitor bank has recently been developed at Loughborough University. An H-configuration circuit is used, with one pair of diagonally opposite arms each comprising a high-voltage ballast inductor and the other pair exploding wire arrays capable of generating voltages up to 300 kV. The two center points of the H configuration provide the output to the load, which is coupled through a high-voltage self-breakdown spark gap, with the entire autonomous source being housed in a metallic container. Experimentally, a load resistance of a few tens of Ohms is provided with an impulse of more than 300 kV, having a rise time of about 140 ns and a peak power of over 1.7 GW. Details of the experimental arrangement and typical results are presented and diagnostic measurements of the current and voltage output are shown to compare well with theoretical predictions based on detailed numerical modeling. Finally, the next stage toward developing a more powerful and energetic transportable source is outlined.

  5. Gasification of high ash, high ash fusion temperature bituminous coals

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Guohai; Vimalchand, Pannalal; Peng, WanWang


    This invention relates to gasification of high ash bituminous coals that have high ash fusion temperatures. The ash content can be in 15 to 45 weight percent range and ash fusion temperatures can be in C. to C. range as well as in excess of C. In a preferred embodiment, such coals are dealt with a two stage gasification process--a relatively low temperature primary gasification step in a circulating fluidized bed transport gasifier followed by a high temperature partial oxidation step of residual char carbon and small quantities of tar. The system to process such coals further includes an internally circulating fluidized bed to effectively cool the high temperature syngas with the aid of an inert media and without the syngas contacting the heat transfer surfaces. A cyclone downstream of the syngas cooler, operating at relatively low temperatures, effectively reduces loading to a dust filtration unit. Nearly dust- and tar-free syngas for chemicals production or power generation and with over 90%, and preferably over about 98%, overall carbon conversion can be achieved with the preferred process, apparatus and methods outlined in this invention.

  6. High-speed signal processing using highly nonlinear optical fibres

    DEFF Research Database (Denmark)

    Peucheret, Christophe; Oxenløwe, Leif Katsuo; Mulvad, Hans Christian Hansen;


    We review recent progress in all-optical signal processing techniques making use of conventional silica-based highly nonlinear fibres. In particular, we focus on recent demonstrations of ultra-fast processing at 640 Gbit/s and above, as well as on signal processing of novel modulation formats...

  7. High-temperature superconductors in high-field magnets

    NARCIS (Netherlands)

    Weijers, Hubertus Wilhelmus


    The properties of both BSCCO conductors and YBCO coated conductors and coils are studied to assess their applicability in high-field magnets. First, the magnetic field dependence of the critical current density in these HTS conductors is measured at 4.2 K in magnetic field conditions ranging from s

  8. High Involvement Mothers of High Achieving Children: Potential Theoretical Explanations (United States)

    Hunsaker, Scott L.


    In American society, parents who have high aspirations for the achievements of their children are often viewed by others in a negative light. Various pejoratives such as "pushy parent," "helicopter parent," "stage mother," and "soccer mom" are used in the common vernacular to describe these parents. Multiple…

  9. High-tech maintenance for high-speed trains

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, Javier Rutz [Nertus Mantenimiento Ferroviario, S.A., Madrid (Spain); Hofmann, Manfred [Siemens AG, Erlangen (Germany). Mobility Div., Integrated Services


    Reliable, punctual trains cannot do without professional maintenance. Nertus S.A., a joint subsidiary of Siemens and Renfe, is responsible for providing precisely this for the Spanish high-speed train, Velaro E (AVE S103), which operates between Madrid and Barcelona. (orig.)

  10. High-temperature MAS-NMR at high spinning speeds. (United States)

    Kirchhain, Holger; Holzinger, Julian; Mainka, Adrian; Spörhase, Andreas; Venkatachalam, Sabarinathan; Wixforth, Achim; van Wüllen, Leo


    A low cost version to enable high temperature MAS NMR experiments at temperatures of up to 700°C and spinning speeds of up to 10kHz is presented. The method relies on inductive heating using a metal coated rotor insert. The metal coating is accomplished via a two step process involving physical vapor deposition and galvanization.

  11. High-Speed Smart Camera with High Resolution

    Directory of Open Access Journals (Sweden)

    J. Dubois


    Full Text Available High-speed video cameras are powerful tools for investigating for instance the biomechanics analysis or the movements of mechanical parts in manufacturing processes. In the past years, the use of CMOS sensors instead of CCDs has enabled the development of high-speed video cameras offering digital outputs, readout flexibility, and lower manufacturing costs. In this paper, we propose a high-speed smart camera based on a CMOS sensor with embedded processing. Two types of algorithms have been implemented. A compression algorithm, specific to high-speed imaging constraints, has been implemented. This implementation allows to reduce the large data flow (6.55 Gbps and to propose a transfer on a serial output link (USB 2.0. The second type of algorithm is dedicated to feature extraction such as edge detection, markers extraction, or image analysis, wavelet analysis, and object tracking. These image processing algorithms have been implemented into an FPGA embedded inside the camera. These implementations are low-cost in terms of hardware resources. This FPGA technology allows us to process in real time 500 images per second with a 1280×1024 resolution. This camera system is a reconfigurable platform, other image processing algorithms can be implemented.

  12. High-Speed Smart Camera with High Resolution

    Directory of Open Access Journals (Sweden)

    Mosqueron R


    Full Text Available High-speed video cameras are powerful tools for investigating for instance the biomechanics analysis or the movements of mechanical parts in manufacturing processes. In the past years, the use of CMOS sensors instead of CCDs has enabled the development of high-speed video cameras offering digital outputs, readout flexibility, and lower manufacturing costs. In this paper, we propose a high-speed smart camera based on a CMOS sensor with embedded processing. Two types of algorithms have been implemented. A compression algorithm, specific to high-speed imaging constraints, has been implemented. This implementation allows to reduce the large data flow (6.55 Gbps and to propose a transfer on a serial output link (USB 2.0. The second type of algorithm is dedicated to feature extraction such as edge detection, markers extraction, or image analysis, wavelet analysis, and object tracking. These image processing algorithms have been implemented into an FPGA embedded inside the camera. These implementations are low-cost in terms of hardware resources. This FPGA technology allows us to process in real time 500 images per second with a 1280×1024 resolution. This camera system is a reconfigurable platform, other image processing algorithms can be implemented.

  13. High Molecular Weight Polybenzimidazole Membranes for High Temperature PEMFC

    DEFF Research Database (Denmark)

    Yang, Jingshuai; Cleemann, Lars Nilausen; Steenberg, T.;


    High temperature operation of proton exchange membrane fuel cells under ambient pressure has been achieved by using phosphoric acid doped polybenzimidazole (PBI) membranes. To optimize the membrane and fuel cells, high performance polymers were synthesized of molecular weights from 30 to 94 k...... showed enhanced chemical stability towards radical attacks under the Fenton test, reduced volume swelling upon the acid doping and improved mechanical strength at acid doping levels of as high as about 11 mol H3PO4 per molar repeat polymer unit. The PBI‐78kDa/10.8PA membrane, for example, exhibited...... tensile strength of 30.3 MPa at room temperature or 7.3 MPa at 130 °C and a proton conductivity of 0.14 S cm–1 at 160 °C. Fuel cell tests with H2 and air at 160 °C showed high open circuit voltage, power density and a low degradation rate of 1.5 μV h–1 at a constant load of 300 mA cm–2....

  14. High Exposure Facility Technical Description

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Gregory L.; Stithem, Arthur R.; Murphy, Mark K.; Smith, Alex K.


    The High Exposure Facility is a collimated high-level gamma irradiator that is located in the basement of the 318 building. It was custom developed by PNNL back in 1982 to meet the needs for high range radiological instrument calibrations and dosimeter irradiations. At the time no commercially available product existed that could create exposure rates up to 20,000 R/h. This document is intended to pass on the design criteria that was employed to create this unique facility, while maintaining compliance with ANSI N543-1974, "General Safety Standard for Installations Using Non-Medical X-Ray and Sealed Gamma-Ray Sources, Energies up to 10 MeV."

  15. High density fluoride glass calorimeter (United States)

    Xie, Q.; Scheltzbaum, J.; Akgun, U.


    The unprecedented radiation levels in current Large Hadron Collider runs, and plans to even increase the luminosity creates a need for new detector technologies to be investigated. Quartz plates to replace the plastic scintillators in current LHC calorimeters have been proposed in recent reports. Quartz based Cherenkov calorimeters can solve the radiation damage problem, however light production and transfer have proven to be challenging. This report summarizes the results from a computational study on the performance of a high-density glass calorimeter. High-density, scintillating, fluoride glass, CHG3, was used as the active material. This glass has been developed specifically for hadron collider experiments, and is known for fast response time, in addition to high light yield. Here, the details of a Geant4 model for a sampling calorimeter prototype with 20 layers, and its hadronic as well as electromagnetic performances are reported.

  16. High average power supercontinuum sources

    Indian Academy of Sciences (India)

    J C Travers


    The physical mechanisms and basic experimental techniques for the creation of high average spectral power supercontinuum sources is briefly reviewed. We focus on the use of high-power ytterbium-doped fibre lasers as pump sources, and the use of highly nonlinear photonic crystal fibres as the nonlinear medium. The most common experimental arrangements are described, including both continuous wave fibre laser systems with over 100 W pump power, and picosecond mode-locked, master oscillator power fibre amplifier systems, with over 10 kW peak pump power. These systems can produce broadband supercontinua with over 50 and 1 mW/nm average spectral power, respectively. Techniques for numerical modelling of the supercontinuum sources are presented and used to illustrate some supercontinuum dynamics. Some recent experimental results are presented.

  17. High pressure processing of meat

    DEFF Research Database (Denmark)

    Grossi, Alberto; Christensen, Mette; Ertbjerg, Per;

    Abstract Background: The research of high pressure (HP) processing of meat based foods needs to address how pressure affects protein interactions, aggregation and/or gelation. The understanding of the gel forming properties of myofibrillar components is fundamental for the development of muscle......–PAGE gels of myofibrillar protein extract from HP treated meat showed that myofibrillar proteins form high molecular weight aggregates after HP treatment. Myofibrillar protein aggregates were stable in a reducing environment, suggesting that disulfide bonds are not the main molecular interactions...... the rheological properties of pork meat batters by inducing formation of protein gels. HP induced protein gels are suggested to be formed by high molecular weight myofibrillar protein aggregates and by peptides formed by lysosomal enzyme-induced cleavage of myofibrillar proteins. Perspectives: The data presented...

  18. Detonation probabilities of high explosives

    Energy Technology Data Exchange (ETDEWEB)

    Eisenhawer, S.W.; Bott, T.F.; Bement, T.R.


    The probability of a high explosive violent reaction (HEVR) following various events is an extremely important aspect of estimating accident-sequence frequency for nuclear weapons dismantlement. In this paper, we describe the development of response curves for insults to PBX 9404, a conventional high-performance explosive used in US weapons. The insults during dismantlement include drops of high explosive (HE), strikes of tools and components on HE, and abrasion of the explosive. In the case of drops, we combine available test data on HEVRs and the results of flooring certification tests to estimate the HEVR probability. For other insults, it was necessary to use expert opinion. We describe the expert solicitation process and the methods used to consolidate the responses. The HEVR probabilities obtained from both approaches are compared.

  19. High power ferrite microwave switch (United States)

    Bardash, I.; Roschak, N. K.


    A high power ferrite microwave switch was developed along with associated electronic driver circuits for operation in a spaceborne high power microwave transmitter in geostationary orbit. Three units were built and tested in a space environment to demonstrate conformance to the required performance characteristics. Each unit consisted of an input magic-tee hybrid, two non-reciprocal latching ferrite phase shifters, an out short-slot 3 db quadrature coupler, a dual driver electronic circuit, and input logic interface circuitry. The basic mode of operation of the high power ferrite microwave switch is identical to that of a four-port, differential phase shift, switchable circulator. By appropriately designing the phase shifters and electronic driver circuits to operate in the flux-transfer magnetization mode, power and temperature insensitive operation was achieved. A list of the realized characteristics of the developed units is given.

  20. High torque miniature rotary actuator (United States)

    Nalbandian, Ruben


    This paper summarizes the design and the development of a miniature rotary actuator (36 mm diameter by 100 mm length) used in spacecraft mechanisms requiring high torques and/or ultra-fine step resolution. This actuator lends itself to applications requiring high torque but with strict volume limitations which challenge the use of conventional rotary actuators. The design challenge was to develop a lightweight (less than 500 grams), very compact, high bandwidth, low power, thermally stable rotary actuator capable of producing torques in excess of 50 N.m and step resolutions as fine as 0.003 degrees. To achieve a relatively high torsional stiffness in excess of 1000 Nm/radian, the design utilizes a combination of harmonic drive and multistage planetary gearing. The unique design feature of this actuator that contributes to its light weight and extremely precise motion capability is a redundant stepper motor driving the output through a multistage reducing gearbox. The rotary actuator is powered by a high reliability space-rated stepper motor designed and constructed by Moog, Inc. The motor is a three-phase stepper motor of 15 degree step angle, producing twenty-four full steps per revolution. Since micro-stepping is not used in the design, and un-powered holding torque is exhibited at every commanded step, the rotary actuator is capable of reacting to torques as high as 35 Nm by holding position with the power off. The output is driven through a gear transmission having a total train ratio of 5120:1, resulting in a resolution of 0.003 degrees output rotation per motor step. The modular design of the multi-stage output transmission makes possible the addition of designs having different output parameters, such as lower torque and higher output speed capability. Some examples of an actuator family based on this growth capability will be presented in the paper.

  1. INL High Performance Building Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Jennifer D. Morton


    High performance buildings, also known as sustainable buildings and green buildings, are resource efficient structures that minimize the impact on the environment by using less energy and water, reduce solid waste and pollutants, and limit the depletion of natural resources while also providing a thermally and visually comfortable working environment that increases productivity for building occupants. As Idaho National Laboratory (INL) becomes the nation’s premier nuclear energy research laboratory, the physical infrastructure will be established to help accomplish this mission. This infrastructure, particularly the buildings, should incorporate high performance sustainable design features in order to be environmentally responsible and reflect an image of progressiveness and innovation to the public and prospective employees. Additionally, INL is a large consumer of energy that contributes to both carbon emissions and resource inefficiency. In the current climate of rising energy prices and political pressure for carbon reduction, this guide will help new construction project teams to design facilities that are sustainable and reduce energy costs, thereby reducing carbon emissions. With these concerns in mind, the recommendations described in the INL High Performance Building Strategy (previously called the INL Green Building Strategy) are intended to form the INL foundation for high performance building standards. This revised strategy incorporates the latest federal and DOE orders (Executive Order [EO] 13514, “Federal Leadership in Environmental, Energy, and Economic Performance” [2009], EO 13423, “Strengthening Federal Environmental, Energy, and Transportation Management” [2007], and DOE Order 430.2B, “Departmental Energy, Renewable Energy, and Transportation Management” [2008]), the latest guidelines, trends, and observations in high performance building construction, and the latest changes to the Leadership in Energy and Environmental Design

  2. Fluorescence for high school students

    CERN Document Server

    Schultheiss, Niek G


    In a not obligatory series of lessons for high school students in the Netherlands we discuss the fluorescence aspects of anthracene. These lessons were developed because HiSPARC (High school Project on Astrophysics Research with Cosmics) detection of cosmic rays are available for different secondary schools. With the help of special designed scintillator detection stations, containing anthracene, cosmic rays can be detected. Fluorescence of anthracene is one of the topics discussed in these series of extra curricular lessons aimed at excellent pupils working on cosmic radiation within the HiSPARC - project.

  3. High-speed pulse techniques

    CERN Document Server

    Coekin, J A


    High-Speed Pulse Techniques covers the many aspects of technique in digital electronics and encompass some of the more fundamental factors that apply to all digital systems. The book describes the nature of pulse signals and their deliberate or inadvertent processing in networks, transmission lines and transformers, and then examines the characteristics and transient performance of semiconductor devices and integrated circuits. Some of the problems associated with the assembly of these into viable systems operating at ultra high speed are also looked at. The book examines the transients and w

  4. High-Average Power Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, David H.; /SLAC; Power, John G.; /Argonne


    There has been significant progress in the development of high-power facilities in recent years yet major challenges remain. The task of WG4 was to identify which facilities were capable of addressing the outstanding R&D issues presently preventing high-power operation. To this end, information from each of the facilities represented at the workshop was tabulated and the results are presented herein. A brief description of the major challenges is given, but the detailed elaboration can be found in the other three working group summaries.

  5. High-frequency complex pitch

    DEFF Research Database (Denmark)

    Santurette, Sébastien; Dau, Torsten


    Harmonics in a complex tone are typically considered unresolved when they interact with neighboring harmonics in the cochlea and cannot be heard out separately. Recent studies have suggested that the low pitch evoked by unresolved high-frequency harmonics may be coded via temporal fine-structure ......Harmonics in a complex tone are typically considered unresolved when they interact with neighboring harmonics in the cochlea and cannot be heard out separately. Recent studies have suggested that the low pitch evoked by unresolved high-frequency harmonics may be coded via temporal fine...

  6. High temperature corrosion in gasifiers

    Directory of Open Access Journals (Sweden)

    Bakker Wate


    Full Text Available Several commercial scale coal gasification combined cycle power plants have been built and successfully operated during the last 5-10 years. Supporting research on materials of construction has been carried out for the last 20 years by EPRI and others. Emphasis was on metallic alloys for heat exchangers and other components in contact with hot corrosive gases at high temperatures. In this paper major high temperature corrosion mechanisms, materials performance in presently operating gasifiers and future research needs will be discussed.

  7. High temperature polymer matrix composites (United States)

    Serafini, Tito T. (Editor)


    These are the proceedings of the High Temperature Polymer Matrix Composites Conference held at the NASA Lewis Research Center on March 16 to 18, 1983. The purpose of the conference is to provide scientists and engineers working in the field of high temperature polymer matrix composites an opportunity to review, exchange, and assess the latest developments in this rapidly expanding area of materials technology. Technical papers are presented in the following areas: (1) matrix development; (2) adhesive development; (3) Characterization; (4) environmental effects; and (5) applications.

  8. High-frequency submicrosecond electroporator

    Directory of Open Access Journals (Sweden)

    Vitalij Novickij


    Full Text Available In this work, we present a novel electroporator which is capable of generating single and bursts of high power (3 kV, 60 A square wave pulses of variable duration (100 ns to 1 ms with predefined repetition frequency (1 Hz to 3.5 MHz. The proposed synchronized crowbar implementation ensures a constant pulse rise and fall times, which are independent from the load, thus highly relevant in electroporation. The electroporator was successfully tested for the inactivation of the human pathogen Candida albicans. The device is compatible with standard commercial electroporation cuvettes.

  9. High-Speed TCP Testing (United States)

    Brooks, David E.; Gassman, Holly; Beering, Dave R.; Welch, Arun; Hoder, Douglas J.; Ivancic, William D.


    Transmission Control Protocol (TCP) is the underlying protocol used within the Internet for reliable information transfer. As such, there is great interest to have all implementations of TCP efficiently interoperate. This is particularly important for links exhibiting long bandwidth-delay products. The tools exist to perform TCP analysis at low rates and low delays. However, for extremely high-rate and lone-delay links such as 622 Mbps over geosynchronous satellites, new tools and testing techniques are required. This paper describes the tools and techniques used to analyze and debug various TCP implementations over high-speed, long-delay links.

  10. Pairing Correlations at High Spins (United States)

    Ma, Hai-Liang; Dong, Bao-Guo; Zhang, Yan; Fan, Ping; Yuan, Da-Qing; Zhu, Shen-Yun; Zhang, Huan-Qiao; Petrache, C. M.; Ragnarsson, I.; Carlsson, B. G.

    The pairing correcting energies at high spins in 161Lu and 138Nd are studied by comparing the results of the cranked-Nilsson-Strutinsky (CNS) and cranked-Nilsson-Strutinsky-Bogoliubov (CNSB) models. It is concluded that the Coriolis effect rather than the rotational alignment effect plays a major role in the reduction of the pairing correlations in the high spin region. Then we proposed an average pairing correction method which not only better reproduces the experimental data comparing with the CNS model but also enables a clean-cut tracing of the configurations thus the full-spin-range discussion on the various rotating bands.

  11. High temperature superconductor current leads

    Energy Technology Data Exchange (ETDEWEB)

    Hull, John R. (Hinsdale, IL); Poeppel, Roger B. (Glen Ellyn, IL)


    An electrical lead having one end for connection to an apparatus in a cryogenic environment and the other end for connection to an apparatus outside the cryogenic environment. The electrical lead includes a high temperature superconductor wire and an electrically conductive material distributed therein, where the conductive material is present at the one end of the lead at a concentration in the range of from 0 to about 3% by volume, and at the other end of the lead at a concentration of less than about 20% by volume. Various embodiments are shown for groups of high temperature superconductor wires and sheaths.

  12. High Energy Astrophysics Program (HEAP) (United States)

    Angelini, Lorella; Corcoran, Michael; Drake, Stephen; McGlynn, Thomas A.; Snowden, Stephen; Mukai, Koji; Cannizzo, John; Lochner, James; Rots, Arnold; Christian, Eric; Barthelmy, Scott; Palmer, David; Mitchell, John; Esposito, Joseph; Sreekumar, P.; Hua, Xin-Min; Mandzhavidze, Natalie; Chan, Kai-Wing; Soong, Yang; Barrett, Paul


    This report reviews activities performed by the members of the USRA contract team during the 6 months of the reporting period and projected activities during the coming 6 months. Activities take place at the Goddard Space Flight Center, within the Laboratory for High Energy Astrophysics. Developments concern instrumentation, observation, data analysis, and theoretical work in astrophysics. Supported missions include advanced Satellite for Cosmology and Astrophysics (ASCA), X-Ray Timing Experiment (XTE), X-Ray Spectrometer (XRS), Astro-E, High Energy Astrophysics Science Archive Research Center (HEASARC) and others.

  13. Nanomaterials under high-pressure. (United States)

    San-Miguel, Alfonso


    The use of high-pressure for the study and elaboration of homogeneous nanostructures is critically reviewed. Size effects, the interaction between nanostructures and guest species or the interaction of the nanosystem with the pressure transmitting medium are emphasized. Phase diagrams and the possibilities opened by the combination of pressure and temperature for the elaboration of new nanomaterials is underlined through the examination of three different systems: nanocrystals, nano-cage materials which include fullerites and group-14 clathrates, and single wall nanotubes. This tutorial review is addressed to scientist seeking an introduction or a panoramic view of the study of nanomaterials under high-pressure.

  14. Building Highly Flexible Polyelectrolyte Nanotubes

    Institute of Scientific and Technical Information of China (English)


    @@ Flexibility of polyelectrolyte nanotubes is necessary if they are to be exploited in applications such as developing photoelectric devices with strong mechanical properties. In a recent attempt, high flexibility has been observed from such nanotubes prepared by a research team headed by Prof. Li Junbai of the CAS Institute of Chemistry (ICCAS).

  15. High-spin nuclear spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, R.M.


    High-spin spectroscopy is the study of the changes in nuclear structure, properties, and behavior with increasing angular momentum. It involves the complex interplay between collective and single-particle motion, between shape and deformation changes, particle alignments, and changes in the pairing correlations. A review of progress in theory, experimentation, and instrumentation in this field is given. (DWL)

  16. English Teaching at Lilydale High. (United States)

    Mayer, Valerie; Matcott, Mark; Lyons, Janet; Flessa, Demi; Hayman, Anna; Hough, Peter


    Presents six narratives from teachers including: "VCE English at Lilydale High School" (Valerie Mayer); "Should 'I' Be Their Teacher" (Mark Matcott); "Teaching Poetry to Year 7 English Students" (Janet Lyons); "Creative Art Therapy and Mandalas" (Demi Flessa); "Would the 'Real' Teacher Please Stand Up?" (Anna Hayman); and "When Volumes Speak…

  17. Challenging High-Ability Students (United States)

    Scager, Karin; Akkerman, Sanne F.; Pilot, Albert; Wubbels, Theo


    The existing literature on indicators of an optimal learning environment for high-ability students frequently discusses the concept of challenge. It is, however, not clear what, precisely, constitutes appropriate challenge for these students. In this study, the authors examined an undergraduate honours course, Advanced Cell Biology, which has…

  18. Challenging high-ability students

    NARCIS (Netherlands)

    Scager, Karin; Akkerman, Sanne F.; Pilot, Albert; Wubbels, Theo; Hafd Onderwijsadvies en training; Leerstoel Vermunt; Faculteit Sociale Wetenschappen; LS Wubbels; Education and Learning: Development in Interaction


    The existing literature on indicators of an optimal learning environment for high-ability students frequently discusses the concept of challenge. It is, however, not clear what, precisely, constitutes appropriate challenge for these students. In this study, the authors examined an undergraduate hono

  19. The State High Biodiesel Project (United States)

    Heasley, Paul L.; Van Der Sluys, William G.


    Through a collaborative project in Pennsylvania, high school students developed a method for converting batches of their cafeteria's waste fryer oil into biodiesel using a 190 L (50 gal) reactor. While the biodiesel is used to supplement the school district's heating and transportation energy needs, the byproduct--glycerol--is used to make hand…

  20. High Performance Bulk Thermoelectric Materials

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Zhifeng [Boston College, Chestnut Hill, MA (United States)


    Over 13 plus years, we have carried out research on electron pairing symmetry of superconductors, growth and their field emission property studies on carbon nanotubes and semiconducting nanowires, high performance thermoelectric materials and other interesting materials. As a result of the research, we have published 104 papers, have educated six undergraduate students, twenty graduate students, nine postdocs, nine visitors, and one technician.

  1. High Resolution Orientation Distribution Function

    DEFF Research Database (Denmark)

    Schmidt, Søren; Gade-Nielsen, Nicolai Fog; Høstergaard, Martin


    A new method for reconstructing a High Resolution Orientation Distribution Function (HRODF) from X-ray diffraction data is presented. It is shown that the method is capable of accommodating very localized features, e.g. sharp peaks from recrystallized grains on a background of a texture component...

  2. High-performance solar collector (United States)

    Beekley, D. C.; Mather, G. R., Jr.


    Evacuated all-glass concentric tube collector using air or liquid transfer mediums is very efficient at high temperatures. Collector can directly drive existing heating systems that are presently driven by fossil fuel with relative ease of conversion and less expense than installation of complete solar heating systems.

  3. High-Ratio Gear Train (United States)

    Lefever, A. E.


    Proposed arrangement of two connected planetary differentials results in gear ratio many times that obtainable in conventional series gear assembly of comparable size. Ratios of several thousand would present no special problems. Selection of many different ratios is available with substantially similar gear diameters. Very high gear ratios would be obtained from small mechanism.

  4. High pressure neon arc lamp (United States)

    Sze, Robert C.; Bigio, Irving J.


    A high pressure neon arc lamp and method of using the same for photodynamic therapies is provided. The high pressure neon arc lamp includes a housing that encloses a quantity of neon gas pressurized to about 500 Torr to about 22,000 Torr. At each end of the housing the lamp is connected by electrodes and wires to a pulse generator. The pulse generator generates an initial pulse voltage to breakdown the impedance of the neon gas. Then the pulse generator delivers a current through the neon gas to create an electrical arc that emits light having wavelengths from about 620 nanometers to about 645 nanometers. A method for activating a photosensitizer is provided. Initially, a photosensitizer is administered to a patient and allowed time to be absorbed into target cells. Then the high pressure neon arc lamp is used to illuminate the target cells with red light having wavelengths from about 620 nanometers to about 645 nanometers. The red light activates the photosensitizers to start a chain reaction that may involve oxygen free radicals to destroy the target cells. In this manner, a high pressure neon arc lamp that is inexpensive and efficiently generates red light useful in photodynamic therapy is provided.

  5. Rethinking the High School Diploma (United States)

    Finn, Chester E., Jr.; Kahlenberg, Richard D.; Kress, Sandy


    As states move to implement the Common Core State Standards, key challenges remain. One is how to make sure a high school diploma acknowledges what students have achieved. Should states adopt a two tiered diploma, in which students who pass internationally aligned Common Core exams at a career- and college-ready level receive an…

  6. Business Education Receives High Marks. (United States)

    Yopp, Martha C.; Brumley, Debbie


    A national survey of state superintendents of public instruction (n=35) and state directors of employment and training (n=28) gives business education programs, courses, and competencies high marks. Suggests that business educators should take advantage of this support by becoming more active in professional organizations. (JOW)

  7. Phenomenology of high colour fermions

    Energy Technology Data Exchange (ETDEWEB)

    Lust, D.; Streng, K.H.; Papantonopoulos, E.; Zoupanos, G.


    We present the phenomenological consequences of a dynamical scenario for electroweak symmetry breaking and generation of fermion masses, involving the presence of fermions which transform under high colour representations. Particular emphasis is given to the predictions for rare processes and to the possible signals in present and future machines. (orig.).

  8. Fast High-Quality Noise

    DEFF Research Database (Denmark)

    Frisvad, Jeppe Revall; Wyvill, Geoff


    , we put a new tool in the box that computes fast high-quality noise. In addition to being free of artifacts, the noise we present does not rely on tabulated data (everything is computed on the fly) and it is easy to adjust quality vs. quantity for the noise. The noise is based on point rendering (like...

  9. Team Teaching in High School (United States)

    Mandel, Kenneth; Eiserman, Terry


    Too often at the high school level, teachers work in isolation, without the ability to see other practitioners at work. Team teaching offers an effective antidote: It provides a comfortable environment in which to grow because it enables teachers to learn from another professional on a regular basis. "Teaming," notes the authors,…

  10. High-density multicore fibers

    DEFF Research Database (Denmark)

    Takenaga, K.; Matsuo, S.; Saitoh, K.;


    High-density single-mode multicore fibers were designed and fabricated. A heterogeneous 30-core fiber realized a low crosstalk of −55 dB. A quasi-single-mode homogeneous 31-core fiber attained the highest core count as a single-mode multicore fiber....

  11. Interface high-temperature superconductivity (United States)

    Wang, Lili; Ma, Xucun; Xue, Qi-Kun


    Cuprate high-temperature superconductors consist of two quasi-two-dimensional (2D) substructures: CuO2 superconducting layers and charge reservoir layers. The superconductivity is realized by charge transfer from the charge reservoir layers into the superconducting layers without chemical dopants and defects being introduced into the latter, similar to modulation-doping in the semiconductor superlattices of AlGaAs/GaAs. Inspired by this scheme, we have been searching for high-temperature superconductivity in ultra-thin films of superconductors epitaxially grown on semiconductor/oxide substrates since 2008. We have observed interface-enhanced superconductivity in both conventional and unconventional superconducting films, including single atomic layer films of Pb and In on Si substrates and single unit cell (UC) films of FeSe on SrTiO3 (STO) substrates. The discovery of high-temperature superconductivity with a superconducting gap of ∼20 meV in 1UC-FeSe/STO has stimulated tremendous interest in the superconductivity community, for it opens a new avenue for both raising superconducting transition temperature and understanding the pairing mechanism of unconventional high-temperature superconductivity. Here, we review mainly the experimental progress on interface-enhanced superconductivity in the three systems mentioned above with emphasis on 1UC-FeSe/STO, studied by scanning tunneling microscopy/spectroscopy, angle-resolved photoemission spectroscopy and transport experiments. We discuss the roles of interfaces and a possible pairing mechanism inferred from these studies.

  12. High power neutron production targets

    Energy Technology Data Exchange (ETDEWEB)

    Wender, S. [Los Alamos National Lab., NM (United States)


    The author describes issues of concern in the design of targets and associated systems for high power neutron production facilities. The facilities include uses for neutron scattering, accelerator driven transmutation, accelerator production of tritium, short pulse spallation sources, and long pulse spallation sources. Each of these applications requires a source with different design needs and consequently different implementation in practise.

  13. High-speed OTDM switching

    DEFF Research Database (Denmark)

    Jepsen, Kim Stokholm; Mikkelsen, Benny; Clausen, Anders


    Optical TDM (OTDM) continues to be of interest both for point-point transmission and as a networking technology for both LANs and long-distance fibre transmission. Recent research has demonstrated enabling techniques for OTDM networks at high speeds. In conclusion, OTDM is emerging as an attracti...

  14. Integrated Nutrition Education: Senior High. (United States)

    Illinois State Board of Education, Springfield.

    Designed for implementation across the school year in existing curriculum areas, 18 nutrition activity units for high school students are provided. Each activity unit consists of a list of coordinated curriculum areas, a statement of objectives, guidelines for teachers, a list of learning activities, and bibliographic citations. Various…

  15. High-Sensitivity Magnetization Measurements

    Institute of Scientific and Technical Information of China (English)


    The three most common instruments for high-sensitivity magnetization measurements (the vibrating-sample magnetometer, the alternating gradient magnetometer, and the SQUID magne tometer) are described and their limiting sensitivities are discussed. The advantages and disad vantages of each are described. Magnetometers using micro-machined force detectors are briefly mentioned.

  16. Vital Signs - High Blood Pressure

    Centers for Disease Control (CDC) Podcasts


    In the U.S., nearly one third of the adult population have high blood pressure, the leading risk factor for heart disease and stroke - two of the nation's leading causes of death.  Created: 10/2/2012 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/17/2012.

  17. High-Temperature Optical Sensor (United States)

    Adamovsky, Grigory; Juergens, Jeffrey R.; Varga, Donald J.; Floyd, Bertram M.


    A high-temperature optical sensor (see Figure 1) has been developed that can operate at temperatures up to 1,000 C. The sensor development process consists of two parts: packaging of a fiber Bragg grating into a housing that allows a more sturdy thermally stable device, and a technological process to which the device is subjected to in order to meet environmental requirements of several hundred C. This technology uses a newly discovered phenomenon of the formation of thermally stable secondary Bragg gratings in communication-grade fibers at high temperatures to construct robust, optical, high-temperature sensors. Testing and performance evaluation (see Figure 2) of packaged sensors demonstrated operability of the devices at 1,000 C for several hundred hours, and during numerous thermal cycling from 400 to 800 C with different heating rates. The technology significantly extends applicability of optical sensors to high-temperature environments including ground testing of engines, flight propulsion control, thermal protection monitoring of launch vehicles, etc. It may also find applications in such non-aerospace arenas as monitoring of nuclear reactors, furnaces, chemical processes, and other hightemperature environments where other measurement techniques are either unreliable, dangerous, undesirable, or unavailable.

  18. An Overview. High Risk Series. (United States)

    General Accounting Office, Washington, DC.

    This report provides an overview of efforts undertaken by the U.S. General Accounting Office (GAO) in 1990 to review and report on federal program areas its work identified as high risk because of vulnerabilities to waste, fraud, abuse, and mismanagement. It reviews the current status of efforts to address these concerns. The six categories of…

  19. Structuring high-protein foods

    NARCIS (Netherlands)

    Purwanti, N.


    Increased protein consumption gives rise to various health benefits. High-protein intake can lead to muscle development, body weight control and suppression of sarcopenia progression. However, increasing the protein content in food products leads to textural changes over time. These changes result i

  20. High Temperature Superconductor Machine Prototype

    DEFF Research Database (Denmark)

    Mijatovic, Nenad; Jensen, Bogi Bech; Træholt, Chresten


    A versatile testing platform for a High Temperature Superconductor (HTS) machine has been constructed. The stationary HTS field winding can carry up to 10 coils and it is operated at a temperature of 77K. The rotating armature is at room temperature. Test results and performance for the HTS field...

  1. Intermolecular Interactions at high pressure

    DEFF Research Database (Denmark)

    Eikeland, Espen Zink


    In this project high-pressure single crystal X-ray diffraction has been combined with quantitative energy calculations to probe the energy landscape of three hydroquinone clathrates enclosing different guest molecules. The simplicity of the hydroquinone clathrate structures together with their st......In this project high-pressure single crystal X-ray diffraction has been combined with quantitative energy calculations to probe the energy landscape of three hydroquinone clathrates enclosing different guest molecules. The simplicity of the hydroquinone clathrate structures together....... High-pressure crystallography is the perfect method for studying intermolecular interactions, by forcing the molecules closer together. In all three studied hydroquinone clathrates, new pressure induced phase transitions have been discovered using a mixture of pentane and isopentane as the pressure...... transmitting medium. Through careful structural analysis combined with theoretical calculations, the structures of all the new high-pressure phases identified herein were determined. In the hydroquinone - methanol and hydroquinone - acetonitrile clathrate structures the phase transitions break the host...

  2. Chemistry of high temperature superconductors

    CERN Document Server


    This review volume contains the most up-to-date articles on the chemical aspects of high temperature oxide superconductors. These articles are written by some of the leading scientists in the field and includes a comprehensive list of references. This is an essential volume for researchers working in the fields of ceramics, materials science and chemistry.

  3. Mexican High Energy Physics Network (United States)

    D'Olivo, J. C.; Napsuciale, M.; Pérez-Angón, M. A.


    The Mexican High Energy Physics Network is one of CONACYT's thematic research networks, created with the aim of increasing the communication and cooperation of the scientific and technology communities of Mexico in strategic areas. In this report we review the evolution, challenges, achievements and opportunities faced by the network.

  4. Obscured AGN at High Redshift (United States)

    Stern, Daniel


    This viewgraph presentation reviews the obscured sources of Active Galactic Nuclei (AGN) in the universe at high redshift. The cosmic X-ray background, unified models of AGN and clues to galaxy formation/evolution is the motivation for this study.

  5. High-Performance Polymeric Materials. (United States)


    interactions, Chain packing, Polybenzobisoxazoles Electrical conductivity Polybenzobisthiazoles Ceramic particles Chain flexibility Elastomer reinforcement...structures for the polybenzobisoxazole (PBO) and polybenzobisthiazole (PBT) chains originally synthesized and much studied because of their utility as...high-performance fibers and films. For cts-PBO, trans-PBO. and trans-PBT chains in their coplanar conformations, the band gaps in the axial direction

  6. Holography in the Junior High. (United States)

    Tomaszkiewicz, Frank


    Examines the use of holography in the art technology program of a junior high school. Characterizing holography as a valuable artistic experience and discovery experience and stressing the importance of student interest and involvement, the author discusses the necessary equipment for the project and includes two diagrams of a holographic setup.…

  7. High luminosity muon collider design

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, R.; Gallardo, J.


    Muon Colliders have unique technical and physics advantages and disadvantages when compared with both hadron and electron machines. They should be regarded as complementary. Parameters are given of 4 TeV high luminosity {mu}{sup +}{mu}{sup {minus}} collider, and of a 0.5 TeV lower luminosity demonstration machine. We discuss the various systems in such muon colliders.

  8. English Teaching at Lilydale High. (United States)

    Mayer, Valerie; Matcott, Mark; Lyons, Janet; Flessa, Demi; Hayman, Anna; Hough, Peter


    Presents six narratives from teachers including: "VCE English at Lilydale High School" (Valerie Mayer); "Should 'I' Be Their Teacher" (Mark Matcott); "Teaching Poetry to Year 7 English Students" (Janet Lyons); "Creative Art Therapy and Mandalas" (Demi Flessa); "Would the 'Real' Teacher Please Stand…

  9. Introduction to High Explosives Science

    Energy Technology Data Exchange (ETDEWEB)

    Skidmore, Cary Bradford [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Preston, Daniel N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    These are a set of slides for educational outreach to children on high explosives science. It gives an introduction to the elements involved in this science: carbon, hydrogen, nitrogen, and oxygen. Combined, these form the molecule HMX. Many pictures are also included to illustrate explosions.

  10. Hard Water or High Ages?

    DEFF Research Database (Denmark)

    Philippsen, Bente


    The aim of this thesis is the investigation of the hardwater effect and its implications for the dating of the first occurrence of pottery in Northern Germany. The hardwater effect denotes the effect of a high carbonate content of freshwater on radiocarbon dating: the dissolved minerals can lead...

  11. Unconventional, High-Efficiency Propulsors

    DEFF Research Database (Denmark)

    Andersen, Poul


    The development of ship propellers has generally been characterized by search for propellers with as high efficiency as possible and at the same time low noise and vibration levels and little or no cavitation. This search has lead to unconventional propulsors, like vane-wheel propulsors, contra-r...

  12. Atomic hydrogen at high redshift

    NARCIS (Netherlands)

    Briggs, FH; Rickman, H


    After the production of the ionizing background by the first generation of stars, neutral gas must be confined to sufficiently high density to be self-shielding and remain neutral. Neutral gas is an identifier of the presence of confining gravitational potentials and a tracer of the kinematics of th

  13. High-Performance Operating Systems

    DEFF Research Database (Denmark)

    Sharp, Robin


    Notes prepared for the DTU course 49421 "High Performance Operating Systems". The notes deal with quantitative and qualitative techniques for use in the design and evaluation of operating systems in computer systems for which performance is an important parameter, such as real-time applications......, communication systems and multimedia systems....

  14. Development of high temperature superconductors having high critical current density

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Gye Wong; Kim, C. J.; Lee, H.G.; Kwon, S. C.; Lee, H. J.; Kim, K. B.; Park, J. Y.; Jung, C. H


    Fabrication of high T{sub c} superconductors and its applications for electric power device were carried out for developing superconductor application technologies. High quality YBCO superconductors was fabricated by melt texture growth, top-seeded melt growth process and multi-seeded melt growth process and the properties was compared. The critical current density of the melt processed YBCO superconductors was about few 10,000 A/cm{sup 2} and the levitation force was 50 N. The processing time needed for the growth of the 123 single grain was greatly reduced by applying multi-seeding without no significant degradation of the levitation force. The multi-seeded melt growth process was confirmed as a time-saving and cost-effective method for the fabrication of bulk superconductors with controlled crystallographic orientation.

  15. Vortices in high-performance high-temperature superconductors (United States)

    Kwok, Wai-Kwong; Welp, Ulrich; Glatz, Andreas; Koshelev, Alexei E.; Kihlstrom, Karen J.; Crabtree, George W.


    The behavior of vortex matter in high-temperature superconductors (HTS) controls the entire electromagnetic response of the material, including its current carrying capacity. Here, we review the basic concepts of vortex pinning and its application to a complex mixed pinning landscape to enhance the critical current and to reduce its anisotropy. We focus on recent scientific advances that have resulted in large enhancements of the in-field critical current in state-of-the-art second generation (2G) YBCO coated conductors and on the prospect of an isotropic, high-critical current superconductor in the iron-based superconductors. Lastly, we discuss an emerging new paradigm of critical current by design—a drive to achieve a quantitative correlation between the observed critical current density and mesoscale mixed pinning landscapes by using realistic input parameters in an innovative and powerful large-scale time dependent Ginzburg-Landau approach to simulating vortex dynamics.

  16. Statistical properties of high-lying chaotic eigenstates

    CERN Document Server

    Li, B; Li, Baowen; Robnik, Marko


    We study the statistical properties of the high-lying chaotic eigenstates (200,000 and above) which are deep in the semiclassical regime. The system we are analyzing is the billiard system inside the region defined by the quadratic (complex) conformal map of the unit disk as introduced by Robnik (1983). We are using Heller's method of plane wave decomposition of the numerical eigenfunctions, and perform extensive statistical analysis with the following conclusions: (1) The local average probability density is in excellent agreement with the microcanonical assumption and all statistical properties are also in excellent agreement with the Gaussian random model; \\qquad (2) The autocorrelation function is found to be strongly direction dependent and only after averaging over all directions agrees well with Berry's (1977) prediction; \\qquad (3) Although the scars of unstable classical periodic orbits (in such ergodic regime) are expected to exist, so far we have not found any (around 200,000th state) but a scar-li...

  17. High perfomance selectable value transportable high dc Voltage standard

    CERN Document Server

    Galliana, Flavio; Tet, Luca Roncaglione


    At National Institute of Metrological Research (INRIM), a selectable-value Transportable High dcVoltage Standard (THVS) operating in the range from 10 V to 100 V in steps of 10 V, was developed. This Standard was built to cover the lack of high level dc Voltage Standards at voltages higher than 10 V to employ as laboratory (local) or travelling Standards for Inter-Laboratory Comparisons (ILCs). A ground-mobile electronic technique was used to enhance the accuracy of the THVS at the higher values. The THVS shows better noise, better short-mid-term stability than top level dc Voltage and multifunction calibrators (MFCs) and better suitability and insensibility to be transported than these instruments. The project is extensible to 1000 V.

  18. Vortices in high-performance high-temperature superconductors. (United States)

    Kwok, Wai-Kwong; Welp, Ulrich; Glatz, Andreas; Koshelev, Alexei E; Kihlstrom, Karen J; Crabtree, George W


    The behavior of vortex matter in high-temperature superconductors (HTS) controls the entire electromagnetic response of the material, including its current carrying capacity. Here, we review the basic concepts of vortex pinning and its application to a complex mixed pinning landscape to enhance the critical current and to reduce its anisotropy. We focus on recent scientific advances that have resulted in large enhancements of the in-field critical current in state-of-the-art second generation (2G) YBCO coated conductors and on the prospect of an isotropic, high-critical current superconductor in the iron-based superconductors. Lastly, we discuss an emerging new paradigm of critical current by design-a drive to achieve a quantitative correlation between the observed critical current density and mesoscale mixed pinning landscapes by using realistic input parameters in an innovative and powerful large-scale time dependent Ginzburg-Landau approach to simulating vortex dynamics.

  19. High performance internal reforming unit for high temperature fuel cells (United States)

    Ma, Zhiwen; Venkataraman, Ramakrishnan; Novacco, Lawrence J.


    A fuel reformer having an enclosure with first and second opposing surfaces, a sidewall connecting the first and second opposing surfaces and an inlet port and an outlet port in the sidewall. A plate assembly supporting a catalyst and baffles are also disposed in the enclosure. A main baffle extends into the enclosure from a point of the sidewall between the inlet and outlet ports. The main baffle cooperates with the enclosure and the plate assembly to establish a path for the flow of fuel gas through the reformer from the inlet port to the outlet port. At least a first directing baffle extends in the enclosure from one of the sidewall and the main baffle and cooperates with the plate assembly and the enclosure to alter the gas flow path. Desired graded catalyst loading pattern has been defined for optimized thermal management for the internal reforming high temperature fuel cells so as to achieve high cell performance.

  20. High-sensitivity, high-speed continuous imaging system (United States)

    Watson, Scott A; Bender, III, Howard A


    A continuous imaging system for recording low levels of light typically extending over small distances with high-frame rates and with a large number of frames is described. Photodiode pixels disposed in an array having a chosen geometry, each pixel having a dedicated amplifier, analog-to-digital convertor, and memory, provide parallel operation of the system. When combined with a plurality of scintillators responsive to a selected source of radiation, in a scintillator array, the light from each scintillator being directed to a single corresponding photodiode in close proximity or lens-coupled thereto, embodiments of the present imaging system may provide images of x-ray, gamma ray, proton, and neutron sources with high efficiency.