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Sample records for cilium coordinates early

  1. The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation

    DEFF Research Database (Denmark)

    Clement, Christian A; Kristensen, Stine G; Møllgård, Kjeld

    2009-01-01

    Defects in the assembly or function of primary cilia, which are sensory organelles, are tightly coupled to developmental defects and diseases in mammals. Here, we investigated the function of the primary cilium in regulating hedgehog signaling and early cardiogenesis. We report that the pluripotent...... P19.CL6 mouse stem cell line, which can differentiate into beating cardiomyocytes, forms primary cilia that contain essential components of the hedgehog pathway, including Smoothened, Patched-1 and Gli2. Knockdown of the primary cilium by Ift88 and Ift20 siRNA or treatment with cyclopamine......, an inhibitor of Smoothened, blocks hedgehog signaling in P19.CL6 cells, as well as differentiation of the cells into beating cardiomyocytes. E11.5 embryos of the Ift88(tm1Rpw) (Ift88-null) mice, which form no cilia, have ventricular dilation, decreased myocardial trabeculation and abnormal outflow tract...

  2. Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair

    DEFF Research Database (Denmark)

    Christensen, Søren T; Pedersen, Stine F; Satir, Peter

    2008-01-01

    Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present...... an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRalpha). We also consider how the primary cilium and the centrosome interact...... with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration....

  3. Cilium assembly and disassembly

    Science.gov (United States)

    2016-01-01

    The primary cilium is an antenna-like, immotile organelle present on most types of mammalian cells, which interprets extracellular signals that regulate growth and development. Although once considered a vestigial organelle, the primary cilium is now the focus of considerable interest. We now know that ciliary defects lead to a panoply of human diseases, termed ciliopathies, and the loss of this organelle may be an early signature event during oncogenic transformation. Ciliopathies include numerous seemingly unrelated developmental syndromes, with involvement of the retina, kidney, liver, pancreas, skeletal system and brain. Recent studies have begun to clarify the key mechanisms that link cilium assembly and disassembly to the cell cycle, and suggest new possibilities for therapeutic intervention. PMID:27350441

  4. Early insulin therapy Coordination Council

    Directory of Open Access Journals (Sweden)

    Marina Vladimirovna Shestakova

    2012-12-01

    Full Text Available Coordination Council has denoted the importance of adherence to Russian and international guidelines and prominent role of insulin therapy in management of type 2 diabetes mellitus (T2DM. Insulin therapy in T2DM preserves endogenous insulin secretion, prevents or decelerates development of microvascular complications and is known to be the most effective glucose-lowering treatment.

  5. The Primary Cilium in Cell Signaling and Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Michaud III, Edward J [ORNL; Yoder, Bradley [University of Alabama, Birmingham

    2006-01-01

    The primary cilium is a microtubule-based antenna-like structure that emanates from the surface of virtually all cells in the mammalian body. It is anchored to the cell by the basal body, which develops from the mother centriole of the centrosome in a manner that is coordinately regulated with the cell cycle. The primary cilium is a sensory organelle that receives both mechanical and chemical signals from other cells and the environment, and transmits these signals to the nucleus to elicit a cellular response. Recent studies revealed that multiple components of the Sonic hedgehog and plateletderived growth factor receptor-A signal transduction pathways localize to the primary cilium, and that loss of the cilium blocks ligand-induced signaling by both pathways. In light of the major role that these pathways play in numerous types of cancer, we anticipate that the emerging discoveries being made about the function of the primary cilium in signaling pathways that are critical for embryonic development and tissue homeostasis in adults will also provide novel insights into the molecular mechanisms of carcinogenesis. (Cancer Res 2006; 66 13): 6463-7)

  6. Primary cilium - antenna-like structure on the surface of most mammalian cell types

    Science.gov (United States)

    Dvorak, J.; Sitorova, V.; Hadzi Nikolov, D.; Mokry, J.; Richter, I.; Kasaova, L.; Filip, S.; Ryska, A.; Petera, J.

    2011-12-01

    The primary cilium is a sensory solitary non-motile microtubule-based organelle protruding in the quiescent phase of the cell cycle from the surface of the majority of human cells, including embryonic cells, stem cells and stromal cells of malignant tumors. The presence of a primary cilium on the surface of a cell is transient, limited to the quiescent G1(G0) phase and the beginning of the S phase of the cell cycle. The primary cilium is formed from the mother centriole. Primary cilia are key coordinators of signaling pathways during development and tissue homeostasis and, when deffective, they are a major cause of human diseases and developmental disorders, now commonly referred to as ciliopathies. Most cancer cells do not possess a primary cilium. The loss of the primary cilium is a regular feature of neoplastic transformation in the majority of solid tumors. The primary cilium could serve as a tumor suppressor organelle. The aim of this paper was to provide a review of the current knowledge of the primary cilium.

  7. 39 CFR 775.7 - Planning and early coordination.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Planning and early coordination. 775.7 Section 775.7 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS NATIONAL ENVIRONMENTAL POLICY ACT PROCEDURES § 775.7 Planning and early coordination. Early planning and coordination...

  8. Mechanosensation and the Primary Cilium

    Science.gov (United States)

    Glaser, Joseph; Resnick, Andrew

    2010-10-01

    The primary cilium has come under increased scrutiny as a site for mechano- and chemosensation by cells. We have undertaken a program of study using mouse renal cell lines from the cortical collecting duct to quantify how mechanical forces arising from fluid shear are transduced into cellular responses. Fluid flow through a model nephron has been analyzed to determine the in vivo forces. A novel tissue culture flow chamber permitting accurate reproduction of physiologically relevant conditions has been calibrated. We have determined that in vivo conditions can be accurately modeled in our flow chamber.

  9. TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

    DEFF Research Database (Denmark)

    Clement, Christian Alexandro; Ajbro, Katrine Dalsgaard; Koefoed, Karen;

    2013-01-01

    Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis. The primary cilium coordinates several signaling pathways, and the pocket surrounding the base and proximal part...

  10. TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

    DEFF Research Database (Denmark)

    Clement, Christian Alexandro; Ajbro, Katrine Dalsgaard; Koefoed, Karen;

    2013-01-01

    Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis. The primary cilium coordinates several signaling pathways, and the pocket surrounding the base and proximal part...... of the cilium is a site for CDE. We report here that TGF-β receptors localize to the ciliary tip and endocytic vesicles at the ciliary base in fibroblasts and that TGF-β stimulation increases receptor localization and activation of SMAD2/3 and ERK1/2 at the ciliary base. Inhibition of CDE reduced TGF......-β-mediated signaling at the cilium, and TGF-β signaling and CDE activity are reduced at stunted primary cilia in Tg737(orpk) fibroblasts. Similarly, TGF-β signaling during cardiomyogenesis correlated with accumulation of TGF-β receptors and activation of SMAD2/3 at the ciliary base. Our results indicate...

  11. Factors That Influence Primary Cilium Length

    Directory of Open Access Journals (Sweden)

    Miyoshi,Ko

    2011-10-01

    Full Text Available Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells;this phenomenon is likely independent of glycogen synthase kinase-3β inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors.

  12. TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

    Directory of Open Access Journals (Sweden)

    Christian Alexandro Clement

    2013-06-01

    Full Text Available Transforming growth factor β (TGF-β signaling is regulated by clathrin-dependent endocytosis (CDE for the control of cellular processes during development and in tissue homeostasis. The primary cilium coordinates several signaling pathways, and the pocket surrounding the base and proximal part of the cilium is a site for CDE. We report here that TGF-β receptors localize to the ciliary tip and endocytic vesicles at the ciliary base in fibroblasts and that TGF-β stimulation increases receptor localization and activation of SMAD2/3 and ERK1/2 at the ciliary base. Inhibition of CDE reduced TGF-β-mediated signaling at the cilium, and TGF-β signaling and CDE activity are reduced at stunted primary cilia in Tg737orpk fibroblasts. Similarly, TGF-β signaling during cardiomyogenesis correlated with accumulation of TGF-β receptors and activation of SMAD2/3 at the ciliary base. Our results indicate that the primary cilium regulates TGF-β signaling and that the ciliary pocket is a compartment for CDE-dependent regulation of signal transduction.

  13. Kinematics of the most efficient cilium

    CERN Document Server

    Eloy, Christophe

    2012-01-01

    In a variety of biological processes, eukaryotic cells use cilia to transport flow. Although cilia have a remarkably conserved internal molecular structure, experimental observations report very diverse kinematics. To address this diversity, we determine numerically the kinematics and energetics of the most efficient cilium. Specifically, we compute the time-periodic deformation of a wall-bound elastic filament leading to transport of a surrounding fluid at minimum energetic cost, where the cost is taken to be the positive work done by all internal molecular motors. The optimal kinematics are found to strongly depend on the cilium bending rigidity through a single dimensionless number, the Sperm number, and closely resemble the two-stroke ciliary beating pattern observed experimentally.

  14. Care Coordination Practices among Illinois Pediatricians and Early Intervention Service Coordinators

    Science.gov (United States)

    Baxter, Marissa

    2015-01-01

    Over the course of the past three decades, largely due to advances in technology, there has been growth in the fields of early intervention (EI) and pediatrics for infants/toddlers with special health care needs (SHCN). This growth has also brought about a change in the relationship between pediatricians and EI service coordinators, creating an…

  15. The Best Performing Cilium: Efficient or Robust?

    CERN Document Server

    Guo, Hanliang

    2015-01-01

    Motile cilia are used by many eukaryotic cells to transport flow. Cilia-driven flows are important to many physiological functions, yet a deep understanding of the interplay between the mechanical structure of cilia and their physiological functions in healthy and diseased conditions remains elusive. For developing such understanding, one needs a quantitative framework for assessing cilia performance and robustness when subject to perturbations in the cilia apparatus. Here, we link cilia design (beating patterns) to function (flow transport) in the context of experimentally- and theoretically-derived cilia models. We particularly examine the optimality and robustness of cilia design. Optimality refers to efficiency of flow transport, while robustness is defined as low sensitivity to variations in the design parameters. We find that suboptimal designs can be more robust than optimal ones. That is, designing for the most efficient cilium does not guarantee robustness. These findings have significant implication...

  16. Mechanical Properties of a Primary Cilium Measured by Resonant Oscillation

    Science.gov (United States)

    Resnick, Andrew

    Primary cilia are ubiquitous mammalian cellular substructures implicated in an ever-increasing number of regulatory pathways. The well-established `ciliary hypothesis' states that physical bending of the cilium (for example, due to fluid flow) initiates signaling cascades, yet the mechanical properties of the cilium remain incompletely measured, resulting in confusion regarding the biological significance of flow-induced ciliary mechanotransduction. In this work we measure the mechanical properties of a primary cilium by using an optical trap to induce resonant oscillation of the structure. Our data indicate 1), the primary cilium is not a simple cantilevered beam, 2), the base of the cilium may be modeled as a nonlinear rotatory spring, the linear spring constant `k' of the cilium base calculated to be (4.6 +/- 0.62)*10-12 N/rad and nonlinear spring constant ` α' to be (-1 +/- 0.34) *10-10 N/rad2 , and 3) the ciliary base may be an essential regulator of mechanotransduction signalling. Our method is also particularly suited to measure mechanical properties of nodal cilia, stereocilia, and motile cilia, anatomically similar structures with very different physiological functions.

  17. Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation.

    Science.gov (United States)

    Falcón-Urrutia, Paulina; Carrasco, Carlos M; Lois, Pablo; Palma, Veronica; Roth, Alejandro D

    2015-01-01

    Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh) and PDGF-Rα, are particularly important for the proliferation and differentiation of oligodendrocytes, suggesting that their interaction occurs in or around this organelle. We identified PC in rat oligodendrocyte precursor cells (OPCs) and found that, while easily detectable in early OPCs, PC are lost as these cells progress to terminal differentiation. We confirmed the interaction between these pathways, as cyclopamine inhibition of Hedgehog function impairs both PDGF-mediated OPC proliferation and Shh-dependent cell branching. However, we failed to detect PDGF-Rα localization into the PC. Remarkably, ciliobrevin-mediated disruption of PC and reduction of OPC process extension was counteracted by recombinant Shh treatment, while PDGF had no effect. Therefore, while PDGF-Rα-dependent OPC proliferation and survival most probably does not initiate at the PC, still the integrity of this organelle and cilium-centered pathway is necessary for OPC survival and differentiation.

  18. The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium

    DEFF Research Database (Denmark)

    Schneider, Linda; Stock, Christian-Martin; Dieterich, Peter;

    2009-01-01

    We previously demonstrated that the primary cilium coordinates platelet-derived growth factor (PDGF) receptor (PDGFR) alpha-mediated migration in growth-arrested fibroblasts. In this study, we investigate the functional relationship between ciliary PDGFR-alpha and the Na(+)/H(+) exchanger NHE1...

  19. CPAP promotes timely cilium disassembly to maintain neural progenitor pool.

    Science.gov (United States)

    Gabriel, Elke; Wason, Arpit; Ramani, Anand; Gooi, Li Ming; Keller, Patrick; Pozniakovsky, Andrei; Poser, Ina; Noack, Florian; Telugu, Narasimha Swamy; Calegari, Federico; Šarić, Tomo; Hescheler, Jürgen; Hyman, Anthony A; Gottardo, Marco; Callaini, Giuliano; Alkuraya, Fowzan Sami; Gopalakrishnan, Jay

    2016-04-15

    A mutation in the centrosomal-P4.1-associated protein (CPAP) causes Seckel syndrome with microcephaly, which is suggested to arise from a decline in neural progenitor cells (NPCs) during development. However, mechanisms ofNPCs maintenance remain unclear. Here, we report an unexpected role for the cilium inNPCs maintenance and identifyCPAPas a negative regulator of ciliary length independent of its role in centrosome biogenesis. At the onset of cilium disassembly,CPAPprovides a scaffold for the cilium disassembly complex (CDC), which includes Nde1, Aurora A, andOFD1, recruited to the ciliary base for timely cilium disassembly. In contrast, mutatedCPAPfails to localize at the ciliary base associated with inefficientCDCrecruitment, long cilia, retarded cilium disassembly, and delayed cell cycle re-entry leading to premature differentiation of patientiPS-derivedNPCs. AberrantCDCfunction also promotes premature differentiation ofNPCs in SeckeliPS-derived organoids. Thus, our results suggest a role for cilia in microcephaly and its involvement during neurogenesis and brain size control.

  20. Regulation of vesicular traffic at the T cell immune synapse: lessons from the primary cilium.

    Science.gov (United States)

    Finetti, Francesca; Onnis, Anna; Baldari, Cosima T

    2015-03-01

    The signals that orchestrate the process of T cell activation are coordinated at the specialized interface that forms upon contact with an antigen presenting cell displaying a specific MHC-associated peptide ligand, known as the immune synapse. The central role of vesicular traffic in the assembly of the immune synapse has emerged only in recent years with the finding that sustained T-cell receptor (TCR) signaling involves delivery of TCR/CD3 complexes from an intracellular pool associated with recycling endosomes. A number of receptors as well as membrane-associated signaling mediators have since been demonstrated to exploit this process to localize to the immune synapse. Here, we will review our current understanding of the mechanisms responsible for TCR recycling, with a focus on the intraflagellar transport system, a multimolecular complex that is responsible for the assembly and function of the primary cilium which we have recently implicated in polarized endosome recycling to the immune synapse.

  1. A Comparative Analysis of the Function of Coordination of Early Childhood Education and Care in France and Italy.

    Science.gov (United States)

    Baudelot, Olga; Rayna, Sylvie; Mayer, Susanna; Musatti, Tullia

    2003-01-01

    Surveyed local early childhood coordinators in France and Italy regarding their status, training, and tasks in order to compare the function of coordinating municipal early childhood education and care services in these two countries. Found impressive similarities in services, policies, and the function of coordination. Also found that service…

  2. Perspectives of Therapist's Role in Care Coordination between Medical and Early Intervention Services

    Science.gov (United States)

    Ideishi, Roger I.; O'Neil, Margaret E.; Chiarello, Lisa A.; Nixon-Cave, Kim

    2010-01-01

    This study explored perspectives of therapist's role in care coordination between early intervention (EI) and medical services, and identified strategies for improving service delivery. Fifty adults participated in one of six focus groups. Participants included parents, pediatricians, and therapists working in hospital and EI programs. Structured…

  3. Toy-oriented changes during early arm movements IV: shoulder-elbow coordination.

    Science.gov (United States)

    Lee, H M; Bhat, A; Scholz, J P; Galloway, J C

    2008-09-01

    Our recent work on the initial emergence of reaching identified a mosaic of developmental changes and consistencies within the hand and joint kinematics of arm movements across the pre-reaching period. The purpose of this study was to test hypotheses regarding the coordination of hand and joint kinematics over this same pre-reaching period. Principal component analysis (PCA) was conducted on hand, shoulder, and elbow kinematic data from 15 full-term infants observed biweekly from 8 weeks of age through the week of reach onset. Separate PCAs were calculated for spatial variables and for velocity variables in trials with a toy and without a toy. From the PCA results, we constructed 'variance profiles' to reflect the coordinative structure of the hand, shoulder, and elbow. By coordinative structure is meant here the relative contribution of each joint to the factors revealed by the PCA. Shifts in these profiles, which reflected coordination changes, were compared across the hand and joints within each pre-reaching phase (Early, Mid, Late) as well as across phases and trial conditions (no-toy and toy). Results identified both surprising consistencies and important developmental changes in coordination. First, over development, spatial coordination changed in different ways for the shoulder and elbow. Between the Early and Late phases, spatial coordination at the shoulder showed more adult-like coordination during both spontaneous movements and movements with a toy present. In contrast, elbow spatial coordination became more adult-like only during movements with a toy and less adult-like during spontaneous movements. Second, over development, velocity coordination became more adult-like at both joints in movements with and without a toy present. We propose that the features of coordination that changed over development suggest explanations for the differential roles and developmental trajectories of the control of arm movements between the shoulder and elbow. We propose

  4. Identification of drugs that restore primary cilium expression in cancer cells.

    Science.gov (United States)

    Khan, Niamat Ali; Willemarck, Nicolas; Talebi, Ali; Marchand, Arnaud; Binda, Maria Mercedes; Dehairs, Jonas; Rueda-Rincon, Natalia; Daniels, Veerle W; Bagadi, Muralidhararao; Thimiri Govinda Raj, Deepak Balaji; Vanderhoydonc, Frank; Munck, Sebastian; Chaltin, Patrick; Swinnen, Johannes V

    2016-03-01

    The development of cancer is often accompanied by a loss of the primary cilium, a microtubule-based cellular protrusion that functions as a cellular antenna and that puts a break on cell proliferation. Hence, restoration of the primary cilium in cancer cells may represent a novel promising approach to attenuate tumor growth. Using a high content analysis-based approach we screened a library of clinically evaluated compounds and marketed drugs for their ability to restore primary cilium expression in pancreatic ductal cancer cells. A diverse set of 118 compounds stimulating cilium expression was identified. These included glucocorticoids, fibrates and other nuclear receptor modulators, neurotransmitter regulators, ion channel modulators, tyrosine kinase inhibitors, DNA gyrase/topoisomerase inhibitors, antibacterial compounds, protein inhibitors, microtubule modulators, and COX inhibitors. Certain compounds also dramatically affected the length of the cilium. For a selection of compounds (Clofibrate, Gefitinib, Sirolimus, Imexon and Dexamethasone) their ability to restore ciliogenesis was confirmed in a panel of human cancer cell line models representing different cancer types (pancreas, lung, kidney, breast). Most compounds attenuated cell proliferation, at least in part through induction of the primary cilium, as demonstrated by cilium removal using chloral hydrate. These findings reveal that several commonly used drugs restore ciliogenesis in cancer cells, and warrant further investigation of their antineoplastic properties.

  5. The exocyst localizes to the primary cilium in MDCK cells.

    Science.gov (United States)

    Rogers, Katherine K; Wilson, Patricia D; Snyder, Richard W; Zhang, Xiaoyu; Guo, Wei; Burrow, Christopher R; Lipschutz, Joshua H

    2004-06-18

    Primary cilia play a role in the maintenance of tubular epithelial differentiation and ciliary dysfunction can result in abnormal cyst formation, such as occurs in autosomal dominant polycystic kidney disease (ADPKD). We previously showed that the exocyst, an eight-protein complex involved in the biogenesis of polarity from yeast to mammals, is centrally involved in cyst formation [Mol. Biol. Cell. 11 (2000) 4259]. Here we show that the exocyst complex localizes to the primary cilium in Madin-Darby canine kidney (MDCK) tubular epithelial cells. We further show that the exocyst is overexpressed in both cell lines and primary cell cultures of ADPKD origin, suggesting that the exocyst may be involved in the pathogenesis of ADPKD.

  6. Deletion of Type 3 Adenylyl Cyclase Perturbs the Postnatal Maturation of Olfactory Sensory Neurons and Olfactory Cilium Ultrastructure in Mice

    Science.gov (United States)

    Zhang, Zhe; Yang, Dong; Zhang, Mengdi; Zhu, Ning; Zhou, Yanfen; Storm, Daniel R.; Wang, Zhenshan

    2017-01-01

    Type 3 adenylyl cyclase (Adcy3) is localized to the cilia of olfactory sensory neurons (OSNs) and is an essential component of the olfactory cyclic adenosine monophosphate (cAMP) signaling pathway. Although the role of this enzyme in odor detection and axonal projection in OSNs was previously characterized, researchers will still have to determine its function in the maturation of postnatal OSNs and olfactory cilium ultrastructure. Previous studies on newborns showed that the anatomic structure of the main olfactory epithelium (MOE) of Adcy3 knockout mice (Adcy3-/-) is indistinguishable from that of their wild-type littermates (Adcy3+/+), whereas the architecture and associated composition of MOE are relatively underdeveloped at this early age. The full effects of sensory deprivation on OSNs may not also be exhibited in such age. In the present study, following a comparison of postnatal OSNs in seven-, 30-, and 90-day-old Adcy3-/- mice and wild-type controls (Adcy3+/+), we observed that the absence of Adcy3 leads to cumulative defects in the maturation of OSNs. Upon aging, Adcy3-/- OSNs exhibited increase in immature cells and reduction in mature cells along with elevated apoptosis levels. The density and ultrastructure of Adcy3-/- cilia were also disrupted in mice upon aging. Collectively, our results reveal an indispensable role of Adcy3 in postnatal maturation of OSNs and maintenance of olfactory cilium ultrastructure in mice through adulthood. PMID:28154525

  7. Intravitreal cilium associated with retinal detachment 40 years following penetrating eye injury: a case report

    OpenAIRE

    Dettoraki, Maria; Andreanos,Konstantinos; Davou, Stavroula; Nomikarios, Nikolaos; Moschos, Marilita M.; Brouzas, Dimitrios

    2015-01-01

    Background The presence of an intraocular cilium is very rare and the response of the eye to the cilium is variable. We present the case of a patient with a cilium found in the vitreous cavity during vitrectomy for rhegmatogenous retinal detachment 40 years following penetrating eye injury. To our knowledge, this is the longest reported presence of a cilium in the vitreous cavity. Case presentation A 70-year-old Caucasian woman presented to the emergency department of our hospital complaining...

  8. Coordinated development of muscles and tendon-like structures: early interactions in the Drosophila leg

    Directory of Open Access Journals (Sweden)

    cedric esoler

    2016-02-01

    Full Text Available The formation of the musculoskeletal system is a remarkable example of tissue assembly. In both vertebrates and invertebrates, precise connectivity between muscles and skeleton (or exoskeleton via tendons or equivalent structures is fundamental for movement and stability of the body. The molecular and cellular processes underpinning muscle formation are well established and significant advances have been made in understanding tendon development. However, the mechanisms contributing to proper connection between these two tissues have received less attention. Observations of coordinated development of tendons and muscles suggest these tissues may interact during the different steps in their development. There is growing evidence that, depending on animal model and muscle type, these interactions can take place from progenitor induction to the final step of the formation of the musculoskeletal system. Here we briefly review and compare the mechanisms behind muscle and tendon interaction throughout the development of vertebrates and Drosophila before going on to discuss our recent findings on the coordinated development of muscles and tendon-like structures in Drosophila leg. By altering apodeme formation (the functional Drosophila equivalent of tendons in vertebrates during the early steps of leg development, we affect the spatial localisation of subsequent myoblasts. These findings provide the first evidence of the developmental impact of early interactions between muscle and tendon-like precursors, and confirm the appendicular Drosophila muscle system as a valuable model for studying these processes.

  9. Nitric oxide coordinates cell proliferation and cell movements during early development of Xenopus.

    Science.gov (United States)

    Peunova, Natalia; Scheinker, Vladimir; Ravi, Kandasamy; Enikolopov, Grigori

    2007-12-15

    The establishment of a vertebrate body plan during embryogenesis is achieved through precise coordination of cell proliferation and morphogenetic cell movements. Here we show that nitric oxide (NO) suppresses cell division and facilitates cell movements during early development of Xenopus, such that inhibition of NO synthase (NOS) increases proliferation in the neuroectoderm and suppresses convergent extension in the axial mesoderm and neuroectoderm. NO controls cell division and cell movement through two separate signaling pathways. Both rely on RhoA-ROCK signaling but can be distinguished by the involvement of either guanylate cyclase or the planar cell polarity regulator Dishevelled. Through the cGMP-dependent pathway, NO suppresses cell division by negatively regulating RhoA and controlling the nuclear distribution of ROCK and p21WAF1. Through the cGMP-independent pathway, NO facilitates cell movement by regulating the intracellular distribution and level of Dishevelled and the activity of RhoA, thereby controlling the activity of ROCK and regulating actin cytoskeleton remodeling and cell polarization. Concurrent control by NO helps ensure that the crucial processes of cell proliferation and morphogenetic movements are coordinated during early development.

  10. Primary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengers.

    Science.gov (United States)

    Pal, Kasturi; Mukhopadhyay, Saikat

    2015-04-01

    The ventral neural tube in vertebrates is patterned by a gradient of sonic hedgehog (Shh) secreted from the notochord and floor plate. Forward genetic screens first pointed to the role of the primary cilium in ventral neural tube patterning. Further research has shown that most components of the Shh pathway localize to or shuttle through the primary cilium. In the absence of Shh, the bifunctional Gli transcription factors are proteolytically processed into repressor forms in a protein kinase A (PKA)- and cilium-dependent manner. Recent work suggests that the orphan G-protein-coupled receptor (GPCR) Gpr161 localizes to cilia, and functions as a negative regulator of Shh signaling by determining Gli processing via cAMP signaling. The primary cilium also functions as a signaling compartment for calcium in the Shh pathway. A better understanding of the role of the cilium as a signaling compartment, and the interplay of second messenger systems that regulate PKA activation and Gli amplification during signaling is critical for deciphering the role of Shh during development, neuronal differentiation, and tumorigenesis.

  11. RssAB signaling coordinates early development of surface multicellularity in Serratia marcescens.

    Directory of Open Access Journals (Sweden)

    Yu-Huan Tsai

    Full Text Available Bacteria can coordinate several multicellular behaviors in response to environmental changes. Among these, swarming and biofilm formation have attracted significant attention for their correlation with bacterial pathogenicity. However, little is known about when and where the signaling occurs to trigger either swarming or biofilm formation. We have previously identified an RssAB two-component system involved in the regulation of swarming motility and biofilm formation in Serratia marcescens. Here we monitored the RssAB signaling status within single cells by tracing the location of the translational fusion protein EGFP-RssB following development of swarming or biofilm formation. RssAB signaling is specifically activated before surface migration in swarming development and during the early stage of biofilm formation. The activation results in the release of RssB from its cognate inner membrane sensor kinase, RssA, to the cytoplasm where the downstream gene promoters are located. Such dynamic localization of RssB requires phosphorylation of this regulator. By revealing the temporal activation of RssAB signaling following development of surface multicellular behavior, our findings contribute to an improved understanding of how bacteria coordinate their lifestyle on a surface.

  12. Tangentially migrating neurons assemble a primary cilium that promotes their reorientation to the cortical plate.

    Science.gov (United States)

    Baudoin, Jean-Pierre; Viou, Lucie; Launay, Pierre-Serge; Luccardini, Camilla; Espeso Gil, Sergio; Kiyasova, Vera; Irinopoulou, Théano; Alvarez, Chantal; Rio, Jean-Paul; Boudier, Thomas; Lechaire, Jean-Pierre; Kessaris, Nicoletta; Spassky, Nathalie; Métin, Christine

    2012-12-20

    In migrating neurons, the centrosome nucleates and anchors a polarized network of microtubules that directs organelle movements. We report here that the mother centriole of neurons migrating tangentially from the medial ganglionic eminence (MGE) assembles a short primary cilium and exposes this cilium to the cell surface by docking to the plasma membrane in the leading process. Primary cilia are built by intraflagellar transport (IFT), which is also required for Sonic hedgehog (Shh) signal transduction in vertebrates. We show that Shh pathway perturbations influenced the leading process morphology and dynamics of MGE cells. Whereas Shh favored the exit of MGE cells away from their tangential migratory paths in the developing cortex, cyclopamine or invalidation of IFT genes maintained MGE cells in the tangential paths. Our findings show that signals transmitted through the primary cilium promote the escape of future GABAergic interneurons from their tangential routes to colonize the cortical plate.

  13. The primary cilium as sensor of fluid flow: new building blocks to the model

    DEFF Research Database (Denmark)

    Prætorius, Helle

    2015-01-01

    functionally as an organelle that makes cells more susceptible to changes in fluid flow. Thus the primary cilium was suggested to function as a flow-sensing device. This characterization has been substantiated for many epithelial cell types over the years. Nevertheless, part of the central mechanism of signal......The primary cilium is an extraordinary organelle. For many years, it had the full attention of only a few dedicated scientists fascinated by its uniqueness. Unexpectedly, after decades of obscurity, it has moved very quickly into the limelight with the increasing evidence of its central role...... transduction has not been explained, largely because of the substantial technical challenges of working with this delicate organelle. The current review considers the recent advances that allow us to fill some of the holes in the model of signal transduction in cilium-mediated responses to fluid flow...

  14. An inverted micro-mixer based on a magnetically-actuated cilium made of Fe doped PDMS

    Science.gov (United States)

    Liu, Fengli; Zhang, Jun; Alici, Gursel; Yan, Sheng; Mutlu, Rahim; Li, Weihua; Yan, Tianhong

    2016-09-01

    In this paper, we report a new micromixer based on a flexible artificial cilium activated by an external magnetic field. The cilium is fabricated from Polydimethylsiloxane doped with Fe microparticles. The fabrication method is based on the standard sacrificial layer technology. The cilium was built on a glass slide, and then was bonded on the top of the micro-mixer chamber in a microfluidic chip. This fabrication process for the miniaturized active mixers is simple and cost effective. An electromagnetic system was used to drive the cilium and induce strong convective flows of the fluid in the chamber. In the presence of an alternating magnetic field, the cilium applied a corresponding alternating force on the surrounding fluids. The performance of the electromagnetically activated cilium was quantified and optimized in order to obtain maximum mixing performance. In addition, the mixing performance of the cilium in a circular micro-chamber was compared with pure diffusion. Up to 80% of a 60 ul liquid in the chamber can be fully mixed after 2 min using a cilium mixer under a magnetic flux density of 22 mT in contrast to the 20 min which were needed to obtain the same mixing percentage under pure diffusion. Furthermore, for a mixing degree of 80%, the mixing speed for the cilia micromixer proposed in this study was 9 times faster than that of the diffusion-based micro-mixers reported in the literature.

  15. B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo.

    Directory of Open Access Journals (Sweden)

    Yuichi Okuda

    2010-05-01

    Full Text Available The B1 SOX transcription factors SOX1/2/3/19 have been implicated in various processes of early embryogenesis. However, their regulatory functions in stages from the blastula to early neurula remain largely unknown, primarily because loss-of-function studies have not been informative to date. In our present study, we systematically knocked down the B1 sox genes in zebrafish. Only the quadruple knockdown of the four B1 sox genes sox2/3/19a/19b resulted in very severe developmental abnormalities, confirming that the B1 sox genes are functionally redundant. We characterized the sox2/3/19a/19b quadruple knockdown embryos in detail by examining the changes in gene expression through in situ hybridization, RT-PCR, and microarray analyses. Importantly, these phenotypic analyses revealed that the B1 SOX proteins regulate the following distinct processes: (1 early dorsoventral patterning by controlling bmp2b/7; (2 gastrulation movements via the regulation of pcdh18a/18b and wnt11, a non-canonical Wnt ligand gene; (3 neural differentiation by regulating the Hes-class bHLH gene her3 and the proneural-class bHLH genes neurog1 (positively and ascl1a (negatively, and regional transcription factor genes, e.g., hesx1, zic1, and rx3; and (4 neural patterning by regulating signaling pathway genes, cyp26a1 in RA signaling, oep in Nodal signaling, shh, and mdkb. Chromatin immunoprecipitation analysis of the her3, hesx1, neurog1, pcdh18a, and cyp26a1 genes further suggests a direct regulation of these genes by B1 SOX. We also found an interesting overlap between the early phenotypes of the B1 sox quadruple knockdown embryos and the maternal-zygotic spg embryos that are devoid of pou5f1 activity. These findings indicate that the B1 SOX proteins control a wide range of developmental regulators in the early embryo through partnering in part with Pou5f1 and possibly with other factors, and suggest that the B1 sox functions are central to coordinating cell fate

  16. Characterization of membrane protein trafficking and cellular signaling at the primary cilium

    DEFF Research Database (Denmark)

    Mogensen, Johanne Bay

    original articles (articles III and IV), which focuses on two specific signaling systems, conducted via the primary cilium; the Sonic hedgehog (SHH) and the Transforming growth factor β (TGFβ) signaling pathways. In article III we show that the motor protein, KIF13B, via its interaction with the transition...

  17. The primary cilium as sensor of fluid flow: new building blocks to the model

    DEFF Research Database (Denmark)

    Prætorius, Helle

    2015-01-01

    functionally as an organelle that makes cells more susceptible to changes in fluid flow. Thus the primary cilium was suggested to function as a flow-sensing device. This characterization has been substantiated for many epithelial cell types over the years. Nevertheless, part of the central mechanism of signal...

  18. A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity

    OpenAIRE

    Santos, Nicole; Reiter, Jeremy F.

    2014-01-01

    Signaling through vertebrate Hedgehog (Hh) proteins depends on the primary cilium. In response to Hh signals, the transcriptional activator of the pathway, Gli2, accumulates at the ciliary tip, raising the possibility that ciliary localization is important for Gli2 activation. To test this hypothesis, we used the Floxin system to create knock-in Gli2 alleles in embryonic stem cells (ESCs) to allow methodical testing of which domains and residues are essential for the ciliary localization of G...

  19. Exploration of Self-Regulation in the Natural Swimming of the Paramecium’s Cilium

    Science.gov (United States)

    2012-02-01

    Produce a Fish’s Pectoral Fin.. A-30 A-21 Sequence Rationalizing the S to L Progression A-31 in LIST OF TABLES Table Page A-l Hydrodynamic...a strobe picture sequence of cilium position during the return stroke produced in the apparatus shown in figure 11. The strobe picture may be...has a cyclic variation. The topology resembles a bent horn, but is not easily describable by a complex Fibonacci function although a start from

  20. The research progress of primary cilium%初级纤毛的研究进展

    Institute of Scientific and Technical Information of China (English)

    王新(综述); 宋庆高; 何苇(审校)

    2016-01-01

    初级纤毛是近年来生物医学领域的一个研究热点。它存在于各种细胞表面,体形微小,结构复杂,具有重要的感官作用,可感知细胞外机械和化学信号变化,并协助其转导至细胞内部引发相应细胞应答。它自身组装、维持和分解所需的蛋白质,需要一组纤毛内转运蛋白来完成,即纤毛内转运系统(intraflagellar transport,IFT)。近年研究表明,初级纤毛与多种先天性疾病密切相关。随着免疫荧光染色、共聚焦显微镜观察等新实验方法的应用,人们对初级纤毛及IFT系统有了更深入的了解,为进一步指导纤毛相关疾病的干预诊疗奠定了基础。%The primary cilium attracts increasing attention in the biomedical field in recent years.It exists in the surface of various cells with a slim pattern,but complex structures and mighty functions as well.The primary cilium has an important role in sensory perception,through which it could receive the mechanical and chemical signals extracellularly,and then assist in their transduction to cells,causing cellular responses.However,assembling,maintaining and disintegrating the proteins of primary cilium depend on intraflagellar transport proteins to finish these processes. And recent research shows that it’s closely related with many congenital diseases.Accompanied with the appearance of various new experimental methods such as immunofluorescence staining and confocal microscopy,the knowledge of the primary cilium and IFT will be mastered better,which will further instruct us the prevention,diagnosis and treatment of the cilia-related diseases.

  1. A Model for the Force Exerted on a Primary Cilium by an Optical Trap and the Resulting Deformation

    Directory of Open Access Journals (Sweden)

    Ian Lofgren

    2015-05-01

    Full Text Available Cilia are slender flexible structures extending from the cell body; genetically similar to flagella. Although their existence has been long known, the mechanical and functional properties of non-motile (“primary” cilia are largely unknown. Optical traps are a non-contact method of applying a localized force to microscopic objects and an ideal tool for the study of ciliary mechanics. We present a method to measure the mechanical properties of a cilium using an analytic model of a flexible, anchored cylinder held within an optical trap. The force density is found using the discrete-dipole approximation. Utilizing Euler-Bernoulli beam theory, we then integrate this force density and numerically obtain the equilibrium deformation of the cilium in response to an optical trap. The presented results demonstrate that optical trapping can provide a great deal of information and insight about the properties and functions of the primary cilium.

  2. Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment.

    Science.gov (United States)

    Natsume, Toyoaki; Müller, Carolin A; Katou, Yuki; Retkute, Renata; Gierliński, Marek; Araki, Hiroyuki; Blow, J Julian; Shirahige, Katsuhiko; Nieduszynski, Conrad A; Tanaka, Tomoyuki U

    2013-06-01

    Centromeres play several important roles in ensuring proper chromosome segregation. Not only do they promote kinetochore assembly for microtubule attachment, but they also support robust sister chromatid cohesion at pericentromeres and facilitate replication of centromeric DNA early in S phase. However, it is still elusive how centromeres orchestrate all these functions at the same site. Here, we show that the budding yeast Dbf4-dependent kinase (DDK) accumulates at kinetochores in telophase, facilitated by the Ctf19 kinetochore complex. This promptly recruits Sld3-Sld7 replication initiator proteins to pericentromeric replication origins so that they initiate replication early in S phase. Furthermore, DDK at kinetochores independently recruits the Scc2-Scc4 cohesin loader to centromeres in G1 phase. This enhances cohesin loading and facilitates robust pericentromeric cohesion in S phase. Thus, we have found the central mechanism by which kinetochores orchestrate early S phase DNA replication and robust sister chromatid cohesion at microtubule attachment sites.

  3. DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Aniek van der Vaart

    2015-12-01

    Full Text Available Cilia are sensory organelles present on almost all vertebrate cells. Cilium length is constant, but varies between cell types, indicating that cilium length is regulated. How this is achieved is unclear, but protein transport in cilia (intraflagellar transport, IFT plays an important role. Several studies indicate that cilium length and function can be modulated by environmental cues. As a model, we study a C. elegans mutant that carries a dominant active G protein α subunit (gpa-3QL, resulting in altered IFT and short cilia. In a screen for suppressors of the gpa-3QL short cilium phenotype, we identified uev-3, which encodes an E2 ubiquitin-conjugating enzyme variant that acts in a MAP kinase pathway. Mutation of two other components of this pathway, dual leucine zipper-bearing MAPKKK DLK-1 and p38 MAPK PMK-3, also suppress the gpa-3QL short cilium phenotype. However, this suppression seems not to be caused by changes in IFT. The DLK-1/p38 pathway regulates several processes, including microtubule stability and endocytosis. We found that reducing endocytosis by mutating rabx-5 or rme-6, RAB-5 GEFs, or the clathrin heavy chain, suppresses gpa-3QL. In addition, gpa-3QL animals showed reduced levels of two GFP-tagged proteins involved in endocytosis, RAB-5 and DPY-23, whereas pmk-3 mutant animals showed accumulation of GFP-tagged RAB-5. Together our results reveal a new role for the DLK-1/p38 MAPK pathway in control of cilium length by regulating RAB-5 mediated endocytosis.

  4. DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans.

    Science.gov (United States)

    van der Vaart, Aniek; Rademakers, Suzanne; Jansen, Gert

    2015-12-01

    Cilia are sensory organelles present on almost all vertebrate cells. Cilium length is constant, but varies between cell types, indicating that cilium length is regulated. How this is achieved is unclear, but protein transport in cilia (intraflagellar transport, IFT) plays an important role. Several studies indicate that cilium length and function can be modulated by environmental cues. As a model, we study a C. elegans mutant that carries a dominant active G protein α subunit (gpa-3QL), resulting in altered IFT and short cilia. In a screen for suppressors of the gpa-3QL short cilium phenotype, we identified uev-3, which encodes an E2 ubiquitin-conjugating enzyme variant that acts in a MAP kinase pathway. Mutation of two other components of this pathway, dual leucine zipper-bearing MAPKKK DLK-1 and p38 MAPK PMK-3, also suppress the gpa-3QL short cilium phenotype. However, this suppression seems not to be caused by changes in IFT. The DLK-1/p38 pathway regulates several processes, including microtubule stability and endocytosis. We found that reducing endocytosis by mutating rabx-5 or rme-6, RAB-5 GEFs, or the clathrin heavy chain, suppresses gpa-3QL. In addition, gpa-3QL animals showed reduced levels of two GFP-tagged proteins involved in endocytosis, RAB-5 and DPY-23, whereas pmk-3 mutant animals showed accumulation of GFP-tagged RAB-5. Together our results reveal a new role for the DLK-1/p38 MAPK pathway in control of cilium length by regulating RAB-5 mediated endocytosis.

  5. The primary cilium is a sensory organelle that regulates growth control and tissue homeostasis

    DEFF Research Database (Denmark)

    Christensen, Søren Tvorup; Schneider, Linda; Clement, Christian Alexandro;

    2006-01-01

    The growth-arrest specific receptor tyrosine kinase, PDGFRa, is up-regulated and targeted to the primary cilium during growth arrest in NIH3T3 cells and primary cultures of mouse embryonic fibroblasts (MEFs), and PDGF-AA-stimulated fibroblast cycle entrance is regulated through activation...... of ciliary PDGFRaa followed by activation of the mitogenic Mek1/2-Erk1/2 pathway, which also operates in the cilium. Quiescent MEFs derived from Tg737orpk mutants fail to form normal cilia and to activate Mek1/2-Erk1/2 and re-enter the cell cycle after stimulation with PDGF-AA [Schneider et al. (2005......) Current Biology]. Prolonged growth arrest in wt cells is associated with activation of p53 and cells remain viable for at least 7 days of serum starvation. In contrast, mutant MEFs fail to activate p53 upon starvation and cells begin to die 2 days after starvation. These results indicate that the primary...

  6. A Simplified Model for the Optical Force exerted on a Vertically Oriented Cilium by an Optical Trap and the Resulting Deformation

    Science.gov (United States)

    Lofgren, Ian; Resnick, Andrew

    2014-03-01

    Eukaryotic cilia are essentially whiplike structures extending from the cell body. Although their existence has been long known, their mechanical and functional properties are poorly understood. Optical traps are a non-contact method of applying a localized force to microscopic objects and an ideal tool for the study of ciliary mechanics. Starting with the discrete dipole approximation, a common means of calculating the optical force on an object that is not spherical, we tackle the problem of the optical force on a cilium. Treating the cilium as a homogeneous nonmagnetic cylinder and the electric field of the laser beam as linearly polarized results in a force applied in the direction of polarization. The force density in the polarization direction is derived from the force on an individual dipole within the cilium, which can be integrated over the volume of the cilium in order to find the total force. Utilizing Euler-Bernoulli beam theory, we integrate the force density over a cross section of the cilium and numerically solve a fourth order differential equation to obtain the final deformation of the cilium. This prediction will later be compared with experimental results to infer the mechanical stiffness of the cilium. Support from the National Institutes of Health, 1R15DK092716 is gratefully acknowledged.

  7. G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning.

    Science.gov (United States)

    Hwang, Sun-Hee; Mukhopadhyay, Saikat

    2015-01-01

    The primary cilium is critical in sonic hedgehog (Shh)-dependent ventral patterning of the vertebrate neural tube. Most mutants that cause disruption of the cilium result in decreased Shh signaling in the neural tube. In contrast, mutations in the intraflagellar complex A (IFT-A) and the tubby family protein, Tulp3, result in increased Shh signaling in the neural tube. Proteomic analysis of Tulp3-binding proteins first pointed to the role of the IFT-A complex in trafficking Tulp3 into the cilia. Tulp3 directs trafficking of rhodopsin family G-protein-coupled receptors (GPCRs) to the cilia, suggesting the role of a GPCR in mediating the paradoxical effects of the Tulp3/IFT-A complex in causing increased Shh signaling. Gpr161 has recently been identified as a Tulp3/IFT-A-regulated GPCR that localizes to the primary cilium. A null knock-out mouse model of Gpr161 phenocopies Tulp3 and IFT-A mutants, and causes increased Shh signaling throughout the neural tube. In the absence of Shh, the bifunctional Gli transcription factors are proteolytically processed into repressor forms in a protein kinase A (PKA) -dependent and cilium-dependent manner. Gpr161 activity results in increased cAMP levels in a Gαs -coupled manner, and determines processing of Gli3. Shh signaling also results in removal of Gpr161 from the cilia, suggesting that Gpr161 functions in a positive feedback loop in the Shh pathway. As PKA-null and Gαs mutant embryos also exhibit increased Shh signaling in the neural tube, Gpr161 is a strong candidate for a GPCR that regulates ciliary cAMP levels, and activates PKA in close proximity to the cilia.

  8. Compartmentalization of signaling by vesicular trafficking: a shared building design for the immune synapse and the primary cilium.

    Science.gov (United States)

    Finetti, Francesca; Baldari, Cosima T

    2013-01-01

    Accumulating evidence underscores the immune synapse (IS) of naive T cells as a site of intense vesicular trafficking. At variance with helper and cytolytic effectors, which use the IS as a secretory platform to deliver cytokines and/or lytic granules to their cellular targets, this process is exploited by naive T cells as a means to regulate the assembly and maintenance of the IS, on which productive signaling and cell activation crucially depend. We have recently identified a role of the intraflagellar transport (IFT) system, which is responsible for the assembly of the primary cilium, in the non-ciliated T-cell, where it controls IS assembly by promoting polarized T-cell receptor recycling. This unexpected finding not only provides new insight into the mechanisms of IS assembly but also strongly supports the notion that the IS and the primary cilium, which are both characterized by a specialized membrane domain highly enriched in receptors and signaling mediators, share architectural similarities and are homologous structures. Here, we review our current understanding of vesicular trafficking in the regulation of the assembly and maintenance of the naive T-cell IS and the primary cilium, with a focus on the IFT system.

  9. A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity.

    Science.gov (United States)

    Santos, Nicole; Reiter, Jeremy F

    2014-04-01

    Signaling through vertebrate Hedgehog (Hh) proteins depends on the primary cilium. In response to Hh signals, the transcriptional activator of the pathway, Gli2, accumulates at the ciliary tip, raising the possibility that ciliary localization is important for Gli2 activation. To test this hypothesis, we used the Floxin system to create knock-in Gli2 alleles in embryonic stem cells (ESCs) to allow methodical testing of which domains and residues are essential for the ciliary localization of Gli2. The Gli2 zinc fingers, transcriptional activation domain, repressor domain, phosphorylation cluster and a Sufu binding motif were each dispensable for ciliary localization. Mutating residues that are required for Gli2 sumoylation and nuclear trafficking also did not abrogate ciliary localization. By contrast, several other domains restricted Gli2 nuclear localization, and a central region, distinct from previously characterized domains, was required for ciliary localization. In addition to an inability to localize to cilia, Gli2 lacking this central domain was unable to activate target genes. Thus, our systematic analysis in ESCs reveals that distinct regions of Gli2 regulate its nuclear and ciliary localization. The identification of a domain essential for both ciliary localization and transcriptional activity suggests that ciliary localization of Gli2 is required for its activation.

  10. 初级纤毛的若干研究进展%Several Research Advances in the Primary Cilium

    Institute of Scientific and Technical Information of China (English)

    张健; 毕新岭; 顾军

    2012-01-01

    The primary cilium is a hot research topic in the biomedical field in recent years. It's a small organelle presenting on the surface of most vertebrate cells, which has a slim pattern, but complex structures and mighty functions as well. The primary cilium has an important role in sensory perception, through which it could receive the mechanical and chemical signals extracellularly, and then assists in their transduction to the interior of the cell, causing cellular responses. The conduction and regulation of multiple developmental signaling pathways, such as Hedgehog and Wnt,are dependent on primary cilium, determining its essential role in the development and ordinary physiological activities of various human tissues and organs, but meanwhile determining the occurrence of a variety of cilia-related diseases,including some genetic diseases and tumors,when its structure and/or function becomes abnormal. Accompanied with the appearance of various new experimental methods such as immunofluorescence staining and confocal microscopy, the knowledge of the primary cilium will be mastered better, which will further instruct us the prevention, diagnosis and treatment of the cilia-related diseases.%初级纤毛是近年来生物医学领域的一个研究热点.它是一种广泛存在于各种细胞表面的细胞器,体形微小但结构复杂,作用强大,具有重要的感官作用,能感知细胞外机械和化学信号变化并协助其转导至细胞内部,从而引起细胞应答.近年发现Hedgehog、Wnt等多种发育信号通路的运行和调控依赖于初级纤毛,决定了它在人体许多组织和器官的发育成形及正常生理活动中扮演重要角色,同时也决定了其结构和功能的异常导致多种纤毛相关疾病的发生,包括一些遗传病和肿瘤等.随着免疫荧光染色、共聚焦显微镜观察等新实验方法的应用,人们对初级纤毛有了更深入的了解,为进一步指导纤毛相关疾病的干预诊疗奠定了基础.

  11. Early coordinated multidisciplinary intervention to prevent sickness absence and labour market exclusion in patients with low back pain

    DEFF Research Database (Denmark)

    Fisker, Annette; Langberg, Henning; Petersen, Tom

    2013-01-01

    Musculoskeletal disorders account for one third of the long-term absenteeism in Denmark and the number of individuals sick listed for more than four weeks is increasing. Compared to other diagnoses, patients with musculoskeletal diseases, including low back pain, are less likely to return to work...... after a period of sick leave. It seems that a multidisciplinary intervention, including cooperation between the health sector, the social sector and in the work place, has a positive effect on days off work due to musculoskeletal disorders and particularly low back pain. It is a challenge to coordinate...... this type of intervention, and the implementation of a return-to-work (RTW)-coordinator is suggested as an effective strategy in this process. The purpose of this paper is to describe the study protocol and present a new type of intervention, where the physiotherapist both has the role as RTW...

  12. Coordination of sucking, swallowing, and breathing and oxygen saturation during early infant breast-feeding and bottle-feeding.

    Science.gov (United States)

    Goldfield, Eugene C; Richardson, Michael J; Lee, Kimberly G; Margetts, Stacey

    2006-10-01

    This prospective study compared the coordination of sucking, swallowing, and breathing and its relationship to oxygen saturation in infants during breast-feeding and bottle-feeding. After 4 to 6 wk of exclusive breast-feeding, infants began bottle-feedings of expressed human milk using one of two systems: a soft-walled bottle and nipple (system 1, Playtex) or a hard-walled bottle and nipple (system 2, Avent). Infants' sucking, swallowing, breathing, and oxygenation were measured during breast-feeding and bottle-feeding, and coordination of these activities during breast-feeding and bottle-feeding were compared. During breast-feeding, swallowing occurred nonrandomly between breaths and did not interfere with breathing. The same distribution of swallowing occurred in infants fed with system 1, while swallowing occurred randomly in infants fed with system 2. Swallowing significantly increased during bottle-feeding among infants using system 2, but decreased among infants using system 1. Infants using system 2 also had a greater instability in the coordination of sucking, swallowing, and breathing and more perturbation of breathing. Oxygen saturation was significantly higher in infants fed with system 1 compared with system 2. These results suggest that the overall feeding pattern and oxygenation of system 1 are closer to the physiologic norm than system 2.

  13. Coordinated Early Intervening Services: Programs in Local Education Agencies that Are Required to Reserve IDEA Funds. inForum

    Science.gov (United States)

    Burdette, Paula; Sopko, Kimberly Moherek

    2010-01-01

    Disproportionate representation of children from diverse racial and ethnic backgrounds in special education has been a longstanding concern that the 2004 reauthorization of the Individuals with Disabilities Education Act (IDEA) sought to address. The IDEA contains new requirements related to the provision of early intervening services designed to…

  14. Toward Interagency Coordination FY '75 Federal Research and Development Activities Pertaining to Early Childhood. Fifth Annual Report.

    Science.gov (United States)

    Hertz, Thomas W.; Mann, Ada Jo

    This report provides an overview of the federally-funded early childhood research activities of fiscal year 1975. In order to assess the directions in which federal research programs are moving, ongoing research projects are analyzed both within individual agencies and within the federal government as a whole. The first chapter reviews the…

  15. Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood.

    Directory of Open Access Journals (Sweden)

    Hennady P Shulha

    2013-04-01

    Full Text Available Development of prefrontal and other higher-order association cortices is associated with widespread changes in the cortical transcriptome, particularly during the transitions from prenatal to postnatal development, and from early infancy to later stages of childhood and early adulthood. However, the timing and longitudinal trajectories of neuronal gene expression programs during these periods remain unclear in part because of confounding effects of concomitantly occurring shifts in neuron-to-glia ratios. Here, we used cell type-specific chromatin sorting techniques for genome-wide profiling of a histone mark associated with transcriptional regulation--H3 with trimethylated lysine 4 (H3K4me3--in neuronal chromatin from 31 subjects from the late gestational period to 80 years of age. H3K4me3 landscapes of prefrontal neurons were developmentally regulated at 1,157 loci, including 768 loci that were proximal to transcription start sites. Multiple algorithms consistently revealed that the overwhelming majority and perhaps all of developmentally regulated H3K4me3 peaks were on a unidirectional trajectory defined by either rapid gain or loss of histone methylation during the late prenatal period and the first year after birth, followed by similar changes but with progressively slower kinetics during early and later childhood and only minimal changes later in life. Developmentally downregulated H3K4me3 peaks in prefrontal neurons were enriched for Paired box (Pax and multiple Signal Transducer and Activator of Transcription (STAT motifs, which are known to promote glial differentiation. In contrast, H3K4me3 peaks subject to a progressive increase in maturing prefrontal neurons were enriched for activating protein-1 (AP-1 recognition elements that are commonly associated with activity-dependent regulation of neuronal gene expression. We uncovered a developmental program governing the remodeling of neuronal histone methylation landscapes in the prefrontal

  16. Coordinated gene expression in adipose tissue and liver differs between cows with high or low NEFA concentrations in early lactation.

    Science.gov (United States)

    van Dorland, H A; Sadri, H; Morel, I; Bruckmaier, R M

    2012-02-01

    Dairy cows with high and low plasma non-esterified fatty acid (NEFA) concentrations in early lactation were compared for plasma parameters and mRNA expression of genes in liver and subcutaneous adipose tissue. The study involved 16 multiparous dairy cows with a plasma NEFA concentration of >500 μmol/l [n = 8, high NEFA (HNEFA)] and Subcutaneous adipose and liver tissues were analysed for mRNA abundance by real-time qRT-PCR encoding parameters related to lipid metabolism. Results showed that mean daily milk yield and milk fat quantity were higher in HNEFA than in LNEFA cows (p carnitine palmitoyltransferase 2 and very long chain acyl-coenzyme A dehydrogenase) and ketogenesis (3-hydroxy-3-methylglutaryl-coenzyme A synthase 2) were lower in HNEFA than in LNEFA cows. No differences between the two groups were observed for mRNA expression of genes in adipose tissue. The number of calculated significant correlation coefficients (moderately strong) between parameters in the liver and in adipose tissue was nearly similar on +1d, and higher for HNEFA compared with LNEFA cows in +3wk. In conclusion, dairy cows with high compared with low plasma NEFA concentrations in early lactation show differentially synchronized mRNA expression of genes in adipose tissue and liver in +3wk that suggests a different orchestrated homeorhetic regulation of lipid metabolism.

  17. International Severe Weather and Flash Flood Hazard Early Warning Systems—Leveraging Coordination, Cooperation, and Partnerships through a Hydrometeorological Project in Southern Africa

    Directory of Open Access Journals (Sweden)

    Robert Jubach

    2016-06-01

    Full Text Available Climate, weather and water hazards do not recognize national boundaries. Transboundary/regional programs and cooperation are essential to reduce the loss of lives and damage to livelihoods when facing these hazards. The development and implementation of systems to provide early warnings for severe weather events such as cyclones and flash floods requires data and information sharing in real time, and coordination among the government agencies at all levels. Within a country, this includes local, municipal, provincial-to-national levels as well as regional and international entities involved in hydrometeorological services and Disaster Risk Reduction (DRR. Of key importance are the National Meteorological and Hydrologic Services (NMHSs. The NMHS is generally the authority solely responsible for issuing warnings for these hazards. However, in many regions of the world, the linkages and interfaces between the NMHS and other agencies are weak or non-existent. Therefore, there is a critical need to assess, strengthen, and formalize collaborations when addressing the concept of reducing risk and impacts from severe weather and floods. The U.S. Agency for International Development/Office of U.S. Foreign Disaster Assistance; the United Nations World Meteorological Organization (WMO; the WMO Southern Africa Regional Specialized Meteorological Center, hosted by the South African Weather Service; the U.S. National Oceanic and Atmospheric Administration/National Weather Service and the Hydrologic Research Center (a non-profit corporation are currently implementing a project working with Southern Africa NMHSs on addressing this gap. The project aims to strengthen coordination and collaboration mechanisms from national to local levels. The project partners are working with the NMHSs to apply and implement appropriate tools and infrastructure to enhance currently operational severe weather and flash flood early warning systems in each country in support of

  18. The Coordination of Independently-Owned Vacuum Tube Patents in the Early Radio Alleged Patent “Thicket”

    DEFF Research Database (Denmark)

    Howells, John; Ron D, Katznelson

    and entrepreneurial exploitation of patents on early vacuum tube technology where Fleming’s diode patent was alleged to have ”overlapped” with De Forest’s triode patents. We show, by means of the relevant historical record, patent claims, litigation records and other relevant law, how patent rights were resolved......It has been proposed that difficulties in negotiating cross-licenses under multiple, independently-owned and ”overlapping” patents may lead entrepreneurs to hold-up or deter development of technology covered by such patents. The literature alleges these features were present in radio development...... during 1905-1920, with numerous allegations of an impasse in bargaining the necessary patent rights for development. This paper seeks to determine with new precision how entrepreneurs and managers actually managed patent rights in this scenario. Accordingly, we re-examine the legal trajectories...

  19. Early

    Directory of Open Access Journals (Sweden)

    Kamel Abd Elaziz Mohamed

    2014-04-01

    Conclusion: Early PDT is recommended for patients who require prolonged tracheal intubation in the ICU as outcomes like the duration of mechanical ventilation length of ICU stay and hospital stay were significantly shorter in early tracheostomy.

  20. Immunohistochemical and ultrastructural characteristics of interstitial cells of Cajal in the rabbit duodenum. Presence of a single cilium.

    Science.gov (United States)

    Junquera, Concepción; Martínez-Ciriano, Carmen; Castiella, Tomás; Serrano, Pedro; Azanza, María Jesús; Junquera, Santiago Ramón y Cajal

    2007-01-01

    Santiago Ramón y Cajal discovered a new type of cell related to the myenteric plexus and also to the smooth muscle cells of the circular muscle layer of the intestine. Based on their morphology, relationships and staining characteristics, he considered these cells as primitive neurons. One century later, despite major improvements in cell biology, the interstitial cells of Cajal (ICCs) are still controversial for many researchers. The aim of study was to perform an immunohistochemical and ultrastructural characterization of the ICCs in the rabbit duodenum. We have found interstitial cells that are positive for c-Kit, CD34 and nestin and are also positive for Ki67 protein, tightly associated with somatic cell proliferation. By means of electron microscopy, we describe ICCs around enteric ganglia. They present triangular or spindle forms and a very voluminous nucleus with scarce perinuclear chromatin surrounded by a thin perinuclear cytoplasm that expands with long cytoplasmic processes. ICC processes penetrate among the smooth muscle cells and couple with the processes of other ICCs located in the connective tissue of the circular muscle layer and establish a three-dimensional network. Intercellular contacts by means of gap-like junctions are frequent. ICCs also establish gap-like junctions with smooth muscle cells. We also observe a population of interstitial cells of stellate morphology in the connective tissue that sur-rounds the muscle bundles in the circular muscle layer, usually close to nervous trunks. These cells establish different types of contacts with the muscle cells around them. In addition, the presence of a single cilium showing a structure 9 + 0 in an ICC is demonstrated for the first time. In conclusion, we report positive staining c-Kit, CD34, nestin and Ki 67. ICCs fulfilled the usual transmission electron microscopy (TEM) criteria. A new ultrastructural characteristic of at least some ICCs is demonstrated: the presence of a single cilium. Some

  1. The coordinated key role of wet, mixed, and dry major mergers in the buildup of massive early-type galaxies at z<~1

    CERN Document Server

    Eliche-Moral, M Carmen; Gallego, Jesus; Zamorano, Jaime

    2010-01-01

    Hierarchical models predict that massive early-type galaxies (mETGs) derive from the most massive and violent merging sequences occurred in the Universe. However, the role of wet, mixed, and dry major mergers in the assembly of mETGs is questioned by some recent observations. We have developed a semi-analytical model to test the feasibility of the major-merger origin hypothesis for mETGs, just accounting for the effects on galaxy evolution of the major mergers strictly reported by observations. The model proves that it is feasible to reproduce the observed number density evolution of mETGs since z~1, just accounting for the coordinated effects of wet/mixed/dry major mergers. It can also reconcile the different assembly redshifts derived by hierarchical models and by mass downsizing data for mETGs, just considering that a mETG observed at a certain redshift is not necessarily in place since then. The model predicts that wet major mergers have controlled the mETGs buildup since z~1, although dry and mixed merge...

  2. Correlation between primary cilium and Wnt signaling pathway%初级纤毛与Wnt信号通路相关性研究进展

    Institute of Scientific and Technical Information of China (English)

    张蔓丽; 卢彦平; 李亚里

    2015-01-01

    Primary cilium is a microtubule-based organelle,which develops from the mother centriole of the centrosome. It is an antenna-like structure that anchors at the cell membrance, protruding from the cell surface. Primary cilium acts as a sensory organelle that receives different kinds of signals from the environment and transmits signals to cells to elicit cellular responses. Recent studies have revealed that primary cilium play an important role in transmitting Wnt signaling, which is critical for embryonic development. Dysfunction of primary cilium deregulates Wnt signaling, causing a series of patho-logical changes in different organs of the embryo, resulting in ciliopathies. In this review, we summarize correlation among primary cilium,Wnt/β-catenin signaling,Wnt/PCP signaling and ciliopathies. Current therapies in ciliopathies are also dis-cussed. Highlights on these researches will encourage the development of Wnt-associated diagnostic tools and therapy for ciliopathies.%初级纤毛是一类以微管为基础结构的细胞器,其来源于细胞的母中心粒,锚定在细胞膜并如“天线”般突出细胞表面。作为细胞感受器,初级纤毛从环境中接受各种信号,传导至细胞内引起细胞反应。近期的研究表明,初级纤毛对与胚胎发育密切相关的 Wnt信号通路的传导起重要作用。纤毛的损害可造成 Wnt信号通路的异常,并引起胚胎中多类脏器一系列的病理改变,导致初级纤毛相关疾病的发生。文章主要阐述了初级纤毛与Wnt/β-catenin、Wnt/PCP通路及初级纤毛相关疾病之间的关系,并对初级纤毛相关疾病的治疗进行了初步探讨。对初级纤毛与Wnt信号通路关系的深入研究将有助于人们对该类疾病的进一步诊断和治疗。

  3. The Research Review of Service Coordination in Early Intervention in Disabled Infants and Young Children in US%美国残疾婴幼儿早期干预中服务协调的研究综述

    Institute of Scientific and Technical Information of China (English)

    颜廷睿

    2014-01-01

    文章从早期干预服务协调的概念和特点出发,强调早期干预服务协调是一个持续性的过程,发挥着中介人的作用。并对服务协调员的角色、服务协调的模式以及服务协调的影响因素进行了综述,为我国的早期干预工作的发展提出一些建议。%This review emphasizes that service coordination in early intervention, as a middleman, is a lasting process in term of the concept and characteristics of service coordination. Then, the author introduces the roles of service coordinator, the models of service coordination and the influential factors. Based on that, the author presents some suggestions for the development of early intervention.

  4. Poisson Coordinates.

    Science.gov (United States)

    Li, Xian-Ying; Hu, Shi-Min

    2013-02-01

    Harmonic functions are the critical points of a Dirichlet energy functional, the linear projections of conformal maps. They play an important role in computer graphics, particularly for gradient-domain image processing and shape-preserving geometric computation. We propose Poisson coordinates, a novel transfinite interpolation scheme based on the Poisson integral formula, as a rapid way to estimate a harmonic function on a certain domain with desired boundary values. Poisson coordinates are an extension of the Mean Value coordinates (MVCs) which inherit their linear precision, smoothness, and kernel positivity. We give explicit formulas for Poisson coordinates in both continuous and 2D discrete forms. Superior to MVCs, Poisson coordinates are proved to be pseudoharmonic (i.e., they reproduce harmonic functions on n-dimensional balls). Our experimental results show that Poisson coordinates have lower Dirichlet energies than MVCs on a number of typical 2D domains (particularly convex domains). As well as presenting a formula, our approach provides useful insights for further studies on coordinates-based interpolation and fast estimation of harmonic functions.

  5. Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts

    DEFF Research Database (Denmark)

    Schneider, Linda; Cammer, Michael; Lehman, Jonathan;

    2010-01-01

    Cell motility and migration play pivotal roles in numerous physiological and pathophysiological processes including development and tissue repair. Cell migration is regulated through external stimuli such as platelet-derived growth factor-AA (PDGF-AA), a key regulator in directional cell migratio...

  6. The Leber congenital amaurosis protein AIPL1 and EB proteins co-localize at the photoreceptor cilium.

    Directory of Open Access Journals (Sweden)

    Juan Hidalgo-de-Quintana

    Full Text Available The aim of this study was to investigate the interaction and co-localization of novel interacting proteins with the Leber congenital amaurosis (LCA associated protein aryl hydrocarbon receptor interacting protein-like 1 (AIPL1.The CytoTrapXR yeast two-hybrid system was used to screen a bovine retinal cDNA library. A novel interaction between AIPL1 and members of the family of EB proteins was confirmed by directed yeast two-hybrid analysis and co-immunoprecipitation assays. The localization of AIPL1 and the EB proteins in cultured cells and in retinal cryosections was examined by immunofluorescence microscopy and cryo-immunogold electron microscopy.Yeast two-hybrid (Y2H analysis identified the interaction between AIPL1 and the EB proteins, EB1 and EB3. EB1 and EB3 were specifically co-immunoprecipitated with AIPL1 from SK-N-SH neuroblastoma cells. In directed 1:1 Y2H analysis, the interaction of EB1 with AIPL1 harbouring the LCA-causing mutations A197P, C239R and W278X was severely compromised. Immunofluorescent confocal microscopy revealed that AIPL1 did not co-localize with endogenous EB1 at the tips of microtubules, endogenous EB1 at the microtubule organising centre following disruption of the microtubule network, or with endogenous β-tubulin. Moreover, AIPL1 did not localize to primary cilia in ARPE-19 cells, whereas EB1 co-localized with the centrosomal marker pericentrin at the base of primary cilia. However, both AIPL1 and the EB proteins, EB1 and EB3, co-localized with centrin-3 in the connecting cilium of photoreceptor cells. Cryo-immunogold electron microscopy confirmed the co-localization of AIPL1 and EB1 in the connecting cilia in human retinal photoreceptors.AIPL1 and the EB proteins, EB1 and EB3, localize at the connecting cilia of retinal photoreceptor cells, but do not co-localize in the cellular microtubule network or in primary cilia in non-retinal cells. These findings suggest that AIPL1 function in these cells is not related

  7. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    Overview From a technical perspective, CMS has been in “beam operation” state since 6th November. The detector is fully closed with all components operational and the magnetic field is normally at the nominal 3.8T. The UXC cavern is normally closed with the radiation veto set. Access to UXC is now only possible during downtimes of LHC. Such accesses must be carefully planned, documented and carried out in agreement with CMS Technical Coordination, Experimental Area Management, LHC programme coordination and the CCC. Material flow in and out of UXC is now strictly controlled. Access to USC remains possible at any time, although, for safety reasons, it is necessary to register with the shift crew in the control room before going down.It is obligatory for all material leaving UXC to pass through the underground buffer zone for RP scanning, database entry and appropriate labeling for traceability. Technical coordination (notably Stephane Bally and Christoph Schaefer), the shift crew and run ...

  8. 早期干预对中枢性协调障碍患儿的疗效观察%Effects of early intervention among children with central coordinative disorder

    Institute of Scientific and Technical Information of China (English)

    张春梅

    2012-01-01

    目的 探讨早期干预对中枢性协调障碍患儿的疗效影响.方法 将82例中枢性协调障碍患儿分成干预组42例,对照组40例,对照组采用常规对症疗法,干预组在此基础上实施水疗、婴幼儿抚触、脑瘫被动操、运动功能训练等干预措施.结果 干预组患儿的临床疗效和治疗后3、6、9、12个月智力发育及1岁时运动功能均优于对照组(P<0.01或P<0.05).结论 对中枢性协调障碍患儿进行早期干预能有效改善智力和运动发育.%Objective To evaluate the effects of early intervention among children with central coordinative disorder. Methods A total of 82 children with central coordinative disorder were divided into experimental group with 42 clients and control group with 40 clients. Routine treatment was applied in the control group,while the experimental group received the comprehensive intervention of hydrotherapy,infantile touching,cerebral palsy passive exercises and motor function training. Results The intellectual development in 3,6,9,12 months after treatment and the motor function in I year old of the experimental group were significantly higher than those of the control group (P <0.01 or P <0.05) . Conclusion The early intervention can improve intelligence and motor development of children with central coordinative disorder.

  9. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    2010-01-01

    Operational Experience At the end of the first full-year running period of LHC, CMS is established as a reliable, robust and mature experiment. In particular common systems and infrastructure faults accounted for <0.6 % CMS downtime during LHC pp physics. Technical operation throughout the entire year was rather smooth, the main faults requiring UXC access being sub-detector power systems and rack-cooling turbines. All such problems were corrected during scheduled technical stops, in the shadow of tunnel access needed by the LHC, or in negotiated accesses or access extensions. Nevertheless, the number of necessary accesses to the UXC averaged more than one per week and the technical stops were inevitably packed with work packages, typically 30 being executed within a few days, placing a high load on the coordination and area management teams. It is an appropriate moment for CMS Technical Coordination to thank all those in many CERN departments and in the Collaboration, who were involved in CMS techni...

  10. Federal Autism Activities: Agencies Are Encouraging Early Identification and Providing Services, and Recent Actions Could Improve Coordination. Report to Congressional Requesters. GAO-16-446

    Science.gov (United States)

    US Government Accountability Office, 2016

    2016-01-01

    Research has shown that early intervention can greatly improve the development of a child with autism. Children with disabilities--including children with autism--can receive intervention services through the Individuals with Disabilities Education Act. Low income children may also receive intervention services through Medicaid or the State…

  11. Coordination Capacity

    CERN Document Server

    Cuff, Paul; Cover, Thomas

    2009-01-01

    We develop elements of a theory of cooperation and coordination in networks. Rather than considering a communication network as a means of distributing information, or of reconstructing random processes at remote nodes, we ask what dependence can be established among the nodes given the communication constraints. Specifically, in a network with communication rates between the nodes, we ask what is the set of all achievable joint distributions p(x1, ..., xm) of actions at the nodes on the network. Several networks are solved, including arbitrarily large cascade networks. Distributed cooperation can be the solution to many problems such as distributed games, distributed control, and establishing mutual information bounds on the influence of one part of a physical system on another.

  12. 急性脑梗死早期行微导管动脉溶栓治疗的护理%The nursing coordination of acute cerebral infarction patients undergoing early arterial thrombolysis

    Institute of Scientific and Technical Information of China (English)

    陈叶香; 易萍; 吕美云

    2011-01-01

    目的 探讨急性脑梗死早期动脉溶栓治疗护理配合的重要性.方法 对37例急性脑梗死早期选择性行微导管动脉溶栓治疗的患者,进行规范的术前准备、术中护理配合、术后的病情观察与护理.结果 37例患者治疗3个月后随访,21例发病6 h内行动脉溶栓治疗预后好的患者占80.95%,16例发病6~24 h行动脉溶栓治疗预后好的患者占68.75%,提高了患者的生存质量.结论 急性脑梗死早期选择性行微导管动脉溶栓治疗疗效良好,行微导管动脉溶栓治疗中规范的术前准备、术中护理配合、术后的病情观察与护理至关重要.%Objective To approach the importance of nursing coordination of early arterial thrombolysis in acute cerebral infarction (ACI). Methods 37 cases of ACI early selective micro-catheter arterial thrombolytic therapy were observed and nursed after the standard preoperative preparation, intraoperative nursing coordination, postoperative condition observation and nursing care. Results 80.95% of 21cases had much improvement of symptoms after arterial thrombolytic therapy and care within 6h;68.75% within 6 ~ 24 h. The rate of disability in patients with ACI were significantly reduced and the quality of life of patients were improved.Conclusions Early selective micro-catheter arterial thrombolytic therapy is of benefit for the acute cerebral infarction patient. The standard preoperative preparation, intraoperative nursing coordination, postoperative condition observation and nursing care are essential.

  13. RUN COORDINATION

    CERN Multimedia

    C. Delaere

    2013-01-01

    Since the LHC ceased operations in February, a lot has been going on at Point 5, and Run Coordination continues to monitor closely the advance of maintenance and upgrade activities. In the last months, the Pixel detector was extracted and is now stored in the pixel lab in SX5; the beam pipe has been removed and ME1/1 removal has started. We regained access to the vactank and some work on the RBX of HB has started. Since mid-June, electricity and cooling are back in S1 and S2, allowing us to turn equipment back on, at least during the day. 24/7 shifts are not foreseen in the next weeks, and safety tours are mandatory to keep equipment on overnight, but re-commissioning activities are slowly being resumed. Given the (slight) delays accumulated in LS1, it was decided to merge the two global runs initially foreseen into a single exercise during the week of 4 November 2013. The aim of the global run is to check that we can run (parts of) CMS after several months switched off, with the new VME PCs installed, th...

  14. RUN COORDINATION

    CERN Multimedia

    Christophe Delaere

    2013-01-01

    The focus of Run Coordination during LS1 is to monitor closely the advance of maintenance and upgrade activities, to smooth interactions between subsystems and to ensure that all are ready in time to resume operations in 2015 with a fully calibrated and understood detector. After electricity and cooling were restored to all equipment, at about the time of the last CMS week, recommissioning activities were resumed for all subsystems. On 7 October, DCS shifts began 24/7 to allow subsystems to remain on to facilitate operations. That culminated with the Global Run in November (GriN), which   took place as scheduled during the week of 4 November. The GriN has been the first centrally managed operation since the beginning of LS1, and involved all subdetectors but the Pixel Tracker presently in a lab upstairs. All nights were therefore dedicated to long stable runs with as many subdetectors as possible. Among the many achievements in that week, three items may be highlighted. First, the Strip...

  15. Co-ordination in morphological leaf traits of early diverging angiosperms is maintained following exposure to experimental palaeo-atmospheric conditions of sub-ambient O2 and elevated CO2

    Directory of Open Access Journals (Sweden)

    Christiana Evans-Fitz.Gerald

    2016-09-01

    Full Text Available In order to be successful in a given environment a plant should invest in a vein network and stomatal distribution that ensures balance between both water supply and demand. Vein density (Dv and stomatal density (SD have been shown to be strongly positively correlated in response to a range of environmental variables in more recently evolved plant species, but the extent of this relationship has not been confirmed in earlier diverging plant lineages. In order to examine the effect of a changing atmosphere on the relationship between Dv and SD, five early-diverging plant species representing two different reproductive plant grades were grown for seven months in a palaeo-treatment comprising an O2:CO2 ratio that has occurred multiple times throughout plant evolutionary history. Results show a range of species-specific Dv and SD responses to the palaeo-treatment, however we show that the strong relationship between Dv and SD under modern ambient atmospheric composition is maintained following exposure to the palaeo-treatment. This suggests strong inter-specific co-ordination between vein and stomatal traits for our study species even under relatively extreme environmental change. This co-ordination supports existing plant function proxies that use the distance between vein endings and stomata (Dm to infer plant palaeo-physiology.

  16. Co-ordination in Morphological Leaf Traits of Early Diverging Angiosperms Is Maintained Following Exposure to Experimental Palaeo-atmospheric Conditions of Sub-ambient O2 and Elevated CO2

    Science.gov (United States)

    Evans-Fitz.Gerald, Christiana; Porter, Amanda S.; Yiotis, Charilaos; Elliott-Kingston, Caroline; McElwain, Jennifer C.

    2016-01-01

    In order to be successful in a given environment a plant should invest in a vein network and stomatal distribution that ensures balance between both water supply and demand. Vein density (Dv) and stomatal density (SD) have been shown to be strongly positively correlated in response to a range of environmental variables in more recently evolved plant species, but the extent of this relationship has not been confirmed in earlier diverging plant lineages. In order to examine the effect of a changing atmosphere on the relationship between Dv and SD, five early-diverging plant species representing two different reproductive plant grades were grown for 7 months in a palaeo-treatment comprising an O2:CO2 ratio that has occurred multiple times throughout plant evolutionary history. Results show a range of species-specific Dv and SD responses to the palaeo-treatment, however, we show that the strong relationship between Dv and SD under modern ambient atmospheric composition is maintained following exposure to the palaeo-treatment. This suggests strong inter-specific co-ordination between vein and stomatal traits for our study species even under relatively extreme environmental change. This co-ordination supports existing plant function proxies that use the distance between vein endings and stomata (Dm) to infer plant palaeo-physiology. PMID:27695464

  17. Motor coordination: a local hub for coordination.

    Science.gov (United States)

    Calabrese, Ronald L

    2014-03-31

    A local interneuron of a crayfish central pattern generator serves as a hub that integrates ascending and descending coordinating information and passes it on to a local oscillatory microcircuit to coordinate a series of segmental appendages known as swimmerets.

  18. TECHNICAL COORDINATION

    CERN Multimedia

    Austin Ball

    2013-01-01

      Since the last report, much visible progress has been made, as the LS1 programme approaches the halfway point. From early October, technical and safety shift-crew have been present around the clock, allowing detectors to stay switched on overnight, ensuring that safety systems are operational and instructions for non-expert shift-crew are clear. LS1 progress Throughout the summer, whilst the solenoid vacuum tank and YB0 surfaces were accessible, an extensive installation programme took place to prepare for Tracker colder operation and the PLT installation, in 2014, the Phase 1 Pixel Tracker installation, in 2016–’17, and the HCAL Phase 1 upgrade completion, ending in LS2. This included pipework for N2 or dry air to flush the Tracker bulkhead region, many sensors to monitor temperature and dew point in the Tracker and its service channels, heating wires outside the Tracker cooling bundles, supports for the new vacuum-jacketed, concentric, CO2 Pixel cooling lines, the PLT cool...

  19. Enhancing Service Coordination Knowledge through Professional

    Science.gov (United States)

    Childress, Dana C.; Raver, Sharon A.; Michalek, Anne M. P.; Wilson, Corinne L.

    2013-01-01

    All eligible infants and toddlers who receive early intervention services under Part C of Individuals with Disabilities Education Act are entitled to service coordination. To examine the effectiveness of one state's service coordination training and its impact on knowledge and skill development, a pretest--posttest design with follow-up survey was…

  20. Enhancing Service Coordination Knowledge through Professional

    Science.gov (United States)

    Childress, Dana C.; Raver, Sharon A.; Michalek, Anne M. P.; Wilson, Corinne L.

    2013-01-01

    All eligible infants and toddlers who receive early intervention services under Part C of Individuals with Disabilities Education Act are entitled to service coordination. To examine the effectiveness of one state's service coordination training and its impact on knowledge and skill development, a pretest--posttest design with follow-up…

  1. Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development.

    Science.gov (United States)

    Zhai, Gang; Gu, Qilin; He, Jiangyan; Lou, Qiyong; Chen, Xiaowen; Jin, Xia; Bi, Erfei; Yin, Zhan

    2014-04-01

    Septins are conserved filament-forming GTP-binding proteins that act as cellular scaffolds or diffusion barriers in a number of cellular processes. However, the role of septins in vertebrate development remains relatively obscure. Here, we show that zebrafish septin 6 (sept6) is first expressed in the notochord and then in nearly all of the ciliary organs, including Kupffer's vesicle (KV), the pronephros, eye, olfactory bulb, and neural tube. Knockdown of sept6 in zebrafish embryos results in reduced numbers and length of cilia in KV. Consequently, cilium-related functions, such as the left-right patterning of internal organs and nodal/spaw signaling, are compromised. Knockdown of sept6 also results in aberrant cilium formation in the pronephros and neural tube, leading to cilium-related defects in pronephros development and Sonic hedgehog (Shh) signaling. We further demonstrate that SEPT6 associates with acetylated α-tubulin in vivo and localizes along the axoneme in the cilia of zebrafish pronephric duct cells as well as cultured ZF4 cells. Our study reveals a novel role of sept6 in ciliogenesis during early embryonic development in zebrafish.

  2. Limitations of Radar Coordinates

    OpenAIRE

    Bini, Donato; Lusanna, Luca; Mashhoon, Bahram

    2004-01-01

    The construction of a radar coordinate system about the world line of an observer is discussed. Radar coordinates for a hyperbolic observer as well as a uniformly rotating observer are described in detail. The utility of the notion of radar distance and the admissibility of radar coordinates are investigated. Our results provide a critical assessment of the physical significance of radar coordinates.

  3. Interlimb Coordination: An Important Facet of Gross-Motor Ability

    Science.gov (United States)

    Bobbio, Tatiana; Gabbard, Carl; Cacola, Priscila

    2009-01-01

    Motor development attains landmark significance during early childhood. Although early childhood educators may be familiar with the gross-motor skill category, the subcategory of interlimb coordination needs greater attention than it typically receives from teachers of young children. Interlimb coordination primarily involves movements requiring…

  4. Colorado Guidelines for Service Coordination: Early Childhood Connections for Infants, Toddlers & Families = Guia para la Coordinacion de Servicios de Colorado: Conexiones para la Ninez Temprana para los Infantes, Parvulos y las Familias.

    Science.gov (United States)

    Miller, Jerri; Petersen, Sandy

    The Individuals with Disabilities Education Act entitles each family with an eligible infant or toddler to service coordination at no cost to them. This publication sets forth guidelines and describes the vision for how service coordination will be provided to families in Colorado. The publication, in English and Spanish versions, notes that…

  5. Coordination and Cooperation

    OpenAIRE

    Janssen, Maarten

    2003-01-01

    textabstractThis comment makes four related points. First, explaining coordination is different from explaining cooperation. Second, solving the coordination problem is more important for the theory of games than solving the cooperation problem. Third, a version of the Principle of Coordination can be rationalized on individualistic grounds. Finally, psychological game theory should consider how players perceive their gaming situation. ---------------------------------------------------------...

  6. Processing Coordination Ambiguity

    Science.gov (United States)

    Engelhardt, Paul E.; Ferreira, Fernanda

    2010-01-01

    We examined temporarily ambiguous coordination structures such as "put the butter in the bowl and the pan on the towel." Minimal Attachment predicts that the ambiguous noun phrase "the pan" will be interpreted as a noun-phrase coordination structure because it is syntactically simpler than clausal coordination. Constraint-based theories assume…

  7. Coordination and Cooperation

    NARCIS (Netherlands)

    M.C.W. Janssen (Maarten)

    2003-01-01

    textabstractThis comment makes four related points. First, explaining coordination is different from explaining cooperation. Second, solving the coordination problem is more important for the theory of games than solving the cooperation problem. Third, a version of the Principle of Coordination can

  8. Enhanced time overcurrent coordination

    Energy Technology Data Exchange (ETDEWEB)

    Enriquez, Arturo Conde; Martinez, Ernesto Vazquez [Universidad Autonoma de Nuevo Leon, Facultad de Ingenieria Mecanica y Electrica, Apdo. Postal 114-F, Ciudad Universitaria, CP 66450 San Nicolas de los Garza, Nuevo Leon (Mexico)

    2006-04-15

    In this paper, we recommend a new coordination system for time overcurrent relays. The purpose of the coordination process is to find a time element function that allows it to operate using a constant back-up time delay, for any fault current. In this article, we describe the implementation and coordination results of time overcurrent relays, fuses and reclosers. Experiments were carried out in a laboratory test situation using signals of a power electrical system physics simulator. (author)

  9. Coordination failure caused by sunspots

    DEFF Research Database (Denmark)

    Beugnot, Julie; Gürgüç, Zeynep; Øvlisen, Frederik Roose;

    2012-01-01

    In a coordination game with Pareto-ranked equilibria, we study whether a sunspot can lead to either coordination on an inferior equilibrium (mis-coordination) or to out-of equilibrium behavior (dis-coordination). While much of the literature searches for mechanisms to attain coordination on the e......In a coordination game with Pareto-ranked equilibria, we study whether a sunspot can lead to either coordination on an inferior equilibrium (mis-coordination) or to out-of equilibrium behavior (dis-coordination). While much of the literature searches for mechanisms to attain coordination...

  10. Social Postural Coordination

    Science.gov (United States)

    Varlet, Manuel; Marin, Ludovic; Lagarde, Julien; Bardy, Benoit G.

    2011-01-01

    The goal of the current study was to investigate whether a visual coupling between two people can produce spontaneous interpersonal postural coordination and change their intrapersonal postural coordination involved in the control of stance. We examined the front-to-back head displacements of participants and the angular motion of their hip and…

  11. Coordinate measuring machines

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    This document is used in connection with three exercises of 2 hours duration as a part of the course GEOMETRICAL METROLOGY AND MACHINE TESTING. The exercises concern three aspects of coordinate measuring: 1) Measuring and verification of tolerances on coordinate measuring machines, 2) Traceabilit...

  12. Team coordination dynamics.

    Science.gov (United States)

    Gorman, Jamie C; Amazeen, Polemnia G; Cooke, Nancy J

    2010-07-01

    Team coordination consists of both the dynamics of team member interaction and the environmental dynamics to which a team is subjected. Focusing on dynamics, an approach is developed that contrasts with traditional aggregate-static concepts of team coordination as characterized by the shared mental model approach. A team coordination order parameter was developed to capture momentary fluctuations in coordination. Team coordination was observed in three-person uninhabited air vehicle teams across two experimental sessions. The dynamics of the order parameter were observed under changes of a team familiarity control parameter. Team members returned for the second session to either the same (Intact) or different (Mixed) team. 'Roadblock' perturbations, or novel changes in the task environment, were introduced in order to probe the stability of team coordination. Nonlinear dynamic methods revealed differences that a traditional approach did not: Intact and Mixed team coordination dynamics looked very different; Mixed teams were more stable than Intact teams and explored the space of solutions without the need for correction. Stability was positively correlated with the number of roadblock perturbations that were overcome successfully. The novel and non-intuitive contribution of a dynamical analysis was that Mixed teams, who did not have a long history working together, were more adaptive. Team coordination dynamics carries new implications for traditional problems such as training adaptive teams.

  13. Coordination models and languages

    NARCIS (Netherlands)

    Papadopoulos, G.A.; Arbab, F.

    1998-01-01

    A new class of models, formalisms and mechanisms has recently evolved for describing concurrent and distributed computations based on the concept of ``coordination''. The purpose of a coordination model and associated language is to provide a means of integrating a number of possibly heterogeneous c

  14. PDGFR alpha signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90(RSK) and AKT signaling pathways

    DEFF Research Database (Denmark)

    Clement, Ditte L.; Mally, Sabine; Stock, Christian;

    2013-01-01

    /2 pathways leading to the activation of the Na+/H+ exchanger, NHE1, cytoplasmic alkalinization and actin nucleation at the lamellipodium that supports directional cell migration. We here show that AKT and MEK1/2-ERK1/2-p90(RSK) inhibition reduced PDGF-AA-induced cell migration by distinct mechanisms: AKT...

  15. Evolution of coordination degree of eco-economic system and early-warning in the Yangtze River Delta%长江三角洲地区生态经济系统协调度及其预警

    Institute of Scientific and Technical Information of China (English)

    WANG Zhenbo; FANG Chuanglin; CHENG Shaowen; WANG Jing

    2013-01-01

    @@%On the basis of Landsat TM data of the Yangtze River Delta (YRD) Economic Zone in 1991,2001 and 2008,this article,taking 90 counties in this region as study units,built spatial data transformation models,ecosystem service value (ESV) and coordination degree of eco-economic system (CDES) models.With the aid of ArcGIS9.3,mass grid and vector data has been processed for spatial analyses.ESV and CDES indexes have demonstrated the relationship between economic development and eco-environment system and its evolution characteristics in the researched areas.Furthermore,the indexes have also been used for functional zoning and pattern recognition.Some results can be shown as follows.Firstly,since 1991,land use in the YRD has greatly changed:urban land area has increased primarily from original paddy land,dry land,grassland,garden plot and other land.Secondly,the ESV model has proved the deterioration trend of the YRD ecological system from 1991 to 2001 and slower degradation trend during 2001-2008.Also,it is illustrated that land-use conversion from water area and paddy field to urban area and dry land could cause great damage to ecosystem stabilization.Thirdly,GDP in the central and southern parts of the YRD is higher than that in the northern part since 1991.GDP growth rate in the central part is higher than that in the northern part during 1991-2001.This growth rate in the central part is also higher than that in the southern and northern parts of the YRD from 2001 to 2008.Fourthly,the YRD could be categorized into 12 types of subregions in terms of CDES index.According to its spatial characteristic of CDES index value in the study area,eco-economic conflict area with low CDES value which is located in the central part is surrounded by eco-coordinated areas with high CDES values.This illustrates a core-periphery spatial structure exists in the YRD.During 1991-2001,the CDES value implied the convergent deterioration trend of eco-economic system in the study area

  16. Uranyl ion coordination

    Science.gov (United States)

    Evans, H.T.

    1963-01-01

    A review of the known crystal structures containing the uranyl ion shows that plane-pentagon coordination is equally as prevalent as plane-square or plane-hexagon. It is suggested that puckered-hexagon configurations of OH - or H2O about the uranyl group will tend to revert to plane-pentagon coordination. The concept of pentagonal coordination is invoked for possible explanations of the complex crystallography of the natural uranyl hydroxides and the unusual behavior of polynuclear ions in hydrolyzed uranyl solutions.

  17. Supercritical Airfoil Coordinates

    Data.gov (United States)

    National Aeronautics and Space Administration — Rectangular Supercritical Wing (Ricketts) - design and measured locations are provided in an Excel file RSW_airfoil_coordinates_ricketts.xls . One sheet is with Non...

  18. Magnetic Coordinate Systems

    CERN Document Server

    Laundal, K M

    2016-01-01

    Geospace phenomena such as the aurora, plasma motion, ionospheric currents and associated magnetic field disturbances are highly organized by Earth's main magnetic field. This is due to the fact that the charged particles that comprise space plasma can move almost freely along magnetic field lines, but not across them. For this reason it is sensible to present such phenomena relative to Earth's magnetic field. A large variety of magnetic coordinate systems exist, designed for different purposes and regions, ranging from the magnetopause to the ionosphere. In this paper we review the most common magnetic coordinate systems and describe how they are defined, where they are used, and how to convert between them. The definitions are presented based on the spherical harmonic expansion coefficients of the International Geomagnetic Reference Field (IGRF) and, in some of the coordinate systems, the position of the Sun which we show how to calculate from the time and date. The most detailed coordinate systems take the...

  19. Dimensions of Organizational Coordination

    DEFF Research Database (Denmark)

    Jensen, Andreas Schmidt; Aldewereld, Huib; Dignum, Virginia

    2013-01-01

    be supported to include organizational objectives and constraints into their reasoning processes by considering two alternatives: agent reasoning and middleware regulation. We show how agents can use an organizational specification to achieve organizational objectives by delegating and coordinating...

  20. Understanding social motor coordination.

    Science.gov (United States)

    Schmidt, R C; Fitzpatrick, Paula; Caron, Robert; Mergeche, Joanna

    2011-10-01

    Recently there has been much interest in social coordination of motor movements, or as it is referred to by some researchers, joint action. This paper reviews the cognitive perspective's common coding/mirror neuron theory of joint action, describes some of its limitations and then presents the behavioral dynamics perspective as an alternative way of understanding social motor coordination. In particular, behavioral dynamics' ability to explain the temporal coordination of interacting individuals is detailed. Two experiments are then described that demonstrate how dynamical processes of synchronization are apparent in the coordination underlying everyday joint actions such as martial art exercises, hand-clapping games, and conversations. The import of this evidence is that emergent dynamic patterns such as synchronization are the behavioral order that any neural substrate supporting joint action (e.g., mirror systems) would have to sustain.

  1. Continuous parallel coordinates.

    Science.gov (United States)

    Heinrich, Julian; Weiskopf, Daniel

    2009-01-01

    Typical scientific data is represented on a grid with appropriate interpolation or approximation schemes,defined on a continuous domain. The visualization of such data in parallel coordinates may reveal patterns latently contained in the data and thus can improve the understanding of multidimensional relations. In this paper, we adopt the concept of continuous scatterplots for the visualization of spatially continuous input data to derive a density model for parallel coordinates. Based on the point-line duality between scatterplots and parallel coordinates, we propose a mathematical model that maps density from a continuous scatterplot to parallel coordinates and present different algorithms for both numerical and analytical computation of the resulting density field. In addition, we show how the 2-D model can be used to successively construct continuous parallel coordinates with an arbitrary number of dimensions. Since continuous parallel coordinates interpolate data values within grid cells, a scalable and dense visualization is achieved, which will be demonstrated for typical multi-variate scientific data.

  2. Coordinating Interactions: The Event Coordination Notation

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    on a much more technical level. The Event Coordination Notation (ECNO) allows modelling the behaviour of an application on a high level of abstraction that is closer to the application’s domain than to the software realizing it. Still, these models contain all necessary details for actually executing...... implementation of ECNO, which consists of a modelling environment based on Eclipse and the Eclipse Modeling Framework (EMF) and an execution engine, which fully supports all the concepts and features of ECNO discussed in this technical report. All the examples are based on EMF, but the ECNO Engine can be used......The purpose of a domain model is to concisely capture the concepts of an application’s domain, and their relation among each other. Even though the main purpose of domain models is not on implementing the application, major parts of an application can be generated from the application’s domain...

  3. Coordinate Standard Measurement Development

    Energy Technology Data Exchange (ETDEWEB)

    Hanshaw, R.A.

    2000-02-18

    A Shelton Precision Interferometer Base, which is used for calibration of coordinate standards, was improved through hardware replacement, software geometry error correction, and reduction of vibration effects. Substantial increases in resolution and reliability, as well as reduction in sampling time, were achieved through hardware replacement; vibration effects were reduced substantially through modification of the machine component dampening and software routines; and the majority of the machine's geometry error was corrected through software geometry error correction. Because of these modifications, the uncertainty of coordinate standards calibrated on this device has been reduced dramatically.

  4. Introduction to Coordination Chemistry

    CERN Document Server

    Lawrance, Geoffrey Alan

    2010-01-01

    Introduction to Coordination Chemistry examines and explains how metals and molecules that bind as ligands interact, and the consequences of this assembly process. This book describes the chemical and physical properties and behavior of the complex assemblies that form, and applications that may arise as a result of these properties. Coordination complexes are an important but often hidden part of our world?even part of us?and what they do is probed in this book. This book distills the essence of this topic for undergraduate students and for research scientists.

  5. Quantifying linguistic coordination

    DEFF Research Database (Denmark)

    Fusaroli, Riccardo; Tylén, Kristian

    ). We employ nominal recurrence analysis (Orsucci et al 2005, Dale et al 2011) on the decision-making conversations between the participants. We report strong correlations between various indexes of recurrence and collective performance. We argue this method allows us to quantify the qualities......Language has been defined as a social coordination device (Clark 1996) enabling innovative modalities of joint action. However, the exact coordinative dynamics over time and their effects are still insufficiently investigated and quantified. Relying on the data produced in a collective decision...

  6. Explicit Spin Coordinates

    CERN Document Server

    Hunter, G; Hunter, Geoffrey; Schlifer, Ian

    2005-01-01

    The recently established existence of spherical harmonic functions, $Y_\\ell^{m}(\\theta,\\phi)$ for half-odd-integer values of $\\ell$ and $m$, allows for the introduction into quantum chemistry of explicit electron spin-coordinates; i.e. spherical polar angles $\\theta_s, \\phi_s$, that specify the orientation of the spin angular momentum vector in space. In this coordinate representation the spin angular momentum operators, $S^2, S_z$, are represented by the usual differential operators in spherical polar coordinates (commonly used for $L^2, L_z$), and their electron-spin eigenfunctions are $\\sqrt{\\sin\\theta_s} \\exp(\\pm\\phi_s/2)$. This eigenfunction representation has the pedagogical advantage over the abstract spin eigenfunctions, $\\alpha, \\beta,$ that ``integration over spin coordinates'' is a true integration (over the angles $\\theta_s, \\phi_s$). In addition they facilitate construction of many electron wavefunctions in which the electron spins are neither parallel nor antiparallel, but inclined at an interme...

  7. Block coordination copolymers

    Energy Technology Data Exchange (ETDEWEB)

    Koh, Kyoung Moo; Wong-Foy, Antek G; Matzger, Adam J; Benin, Annabelle I; Willis, Richard R

    2014-11-11

    The present invention provides compositions of crystalline coordination copolymers wherein multiple organic molecules are assembled to produce porous framework materials with layered or core-shell structures. These materials are synthesized by sequential growth techniques such as the seed growth technique. In addition, the invention provides a simple procedure for controlling functionality.

  8. Coordinating Work with Groupware

    DEFF Research Database (Denmark)

    Pors, Jens Kaaber; Simonsen, Jesper

    2003-01-01

    One important goal of employing groupware is to make possible complex collaboration between geographically distributed groups. This requires a dual transformation of both technology and work practice. The challenge is to re­duce the complexity of the coordination work by successfully inte­grating...

  9. Recursive Advice for Coordination

    DEFF Research Database (Denmark)

    Terepeta, Michal Tomasz; Nielson, Hanne Riis; Nielson, Flemming

    2012-01-01

    Aspect-oriented programming is a programming paradigm that is often praised for the ability to create modular software and separate cross-cutting concerns. Recently aspects have been also considered in the context of coordination languages, offering similar advantages. However, introducing aspects...

  10. Block coordination copolymers

    Science.gov (United States)

    Koh, Kyoung Moo; Wong-Foy, Antek G; Matzger, Adam J; Benin, Annabelle I; Willis, Richard R

    2012-11-13

    The present invention provides compositions of crystalline coordination copolymers wherein multiple organic molecules are assembled to produce porous framework materials with layered or core-shell structures. These materials are synthesized by sequential growth techniques such as the seed growth technique. In addition, the invention provides a simple procedure for controlling functionality.

  11. The evolution of coordinated vocalizations before language.

    Science.gov (United States)

    Bryant, Gregory A

    2014-12-01

    Ackermann et al. briefly point out the potential significance of coordinated vocal behavior in the dual pathway model of acoustic communication. Rhythmically entrained and articulated pre-linguistic vocal activity in early hominins might have set the evolutionary stage for later refinements that manifest in modern humans as language-based conversational turn-taking, joint music-making, and other behaviors associated with prosociality.

  12. Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium.

    Science.gov (United States)

    Caparrós-Martín, José A; De Luca, Alessandro; Cartault, François; Aglan, Mona; Temtamy, Samia; Otaify, Ghada A; Mehrez, Mennat; Valencia, María; Vázquez, Laura; Alessandri, Jean-Luc; Nevado, Julián; Rueda-Arenas, Inmaculada; Heath, Karen E; Digilio, Maria Cristina; Dallapiccola, Bruno; Goodship, Judith A; Mill, Pleasantine; Lapunzina, Pablo; Ruiz-Perez, Victor L

    2015-07-15

    Most patients with Ellis-van Creveld syndrome (EvC) are identified with pathogenic changes in EVC or EVC2, however further genetic heterogeneity has been suggested. In this report we describe pathogenic splicing variants in WDR35, encoding retrograde intraflagellar transport protein 121 (IFT121), in three families with a clinical diagnosis of EvC but having a distinctive phenotype. To understand why WDR35 variants result in EvC, we analysed EVC, EVC2 and Smoothened (SMO) in IFT-A deficient cells. We found that the three proteins failed to localize to Wdr35(-/-) cilia, but not to the cilium of the IFT retrograde motor mutant Dync2h1(-/-), indicating that IFT121 is specifically required for their entry into the ciliary compartment. Furthermore expression of Wdr35 disease cDNAs in Wdr35(-/-) fibroblasts revealed that the newly identified variants lead to Hedgehog signalling defects resembling those of Evc(-/-) and Evc2(-/-) mutants. Together our data indicate that splicing variants in WDR35, and possibly in other IFT-A components, underlie a number of EvC cases by disrupting targeting of both the EvC complex and SMO to cilia.

  13. The EHDI and Early Intervention Connection

    Science.gov (United States)

    Nelson, Lauri; Bradham, Tamala S.; Houston, K. Todd

    2011-01-01

    State coordinators of early hearing detection and intervention (EHDI) programs completed a strengths, weaknesses, opportunities, and threats, or SWOT, analysis that examined 12 areas within state EHDI programs. For the early intervention focus question, 48 coordinators listed 273 items, and themes were identified within each SWOT category. A…

  14. Global Coordinate System

    Science.gov (United States)

    1985-02-01

    Time in hours at Oh UT is GAST (hours) = GMST + E (41) GAST in radians is GASTo (radians) = GAST (hours) L (42) The angle e required for transforming...inertial coordinates to ECEF is- 6(radians) GASTo + 6.3003880.99 (ti - th) (43) o ~ooUT Mod ( E 27) where St.i - tohLjT = (JD -2.4 106). (JDOE -2.4 x

  15. Universal mechatronics coordinator

    Science.gov (United States)

    Muir, Patrick F.

    1999-11-01

    Mechatronic systems incorporate multiple actuators and sensor which must be properly coordinated to achieve the desired system functionality. Many mechatronic systems are designed as one-of-a-kind custom projects without consideration for facilitating future system or alterations and extensions to the current syste. Thus, subsequent changes to the system are slow, different, and costly. It has become apparent that manufacturing processes, and thus the mechatronics which embody them, need to be agile in order to more quickly and easily respond to changing customer demands or market pressures. To achieve agility, both the hardware and software of the system need to be designed such that the creation of new system and the alteration and extension of current system is fast and easy. This paper describes the design of a Universal Mechatronics Coordinator (UMC) which facilitates agile setup and changeover of coordination software for mechatronic systems. The UMC is capable of sequencing continuous and discrete actions that are programmed as stimulus-response pairs, as state machines, or a combination of the two. It facilitates the modular, reusable programing of continuous actions such as servo control algorithms, data collection code, and safety checking routines; and discrete actions such as reporting achieved states, and turning on/off binary devices. The UMC has been applied to the control of a z- theta assembly robot for the Minifactory project and is applicable to a spectrum of widely differing mechatronic systems.

  16. Determinants of developmental coordination disorder in 7-year-old children

    DEFF Research Database (Denmark)

    Faebo Larsen, Rikke; Hvas Mortensen, Laust; Martinussen, Torben;

    2013-01-01

    The aim of this study was to investigate early life determinants of developmental coordination disorder (DCD) in 7-year-old children.......The aim of this study was to investigate early life determinants of developmental coordination disorder (DCD) in 7-year-old children....

  17. Symmetric two-coordinate photodiode

    Directory of Open Access Journals (Sweden)

    Dobrovolskiy Yu. G.

    2008-12-01

    Full Text Available The two-coordinate photodiode is developed and explored on the longitudinal photoeffect, which allows to get the coordinate descriptions symmetric on the steepness and longitudinal resistance great exactness. It was shown, that the best type of the coordinate description is observed in the case of scanning by the optical probe on the central part of the photosensitive element. The ways of improvement of steepness and linear of its coordinate description were analyzed.

  18. Invariant Manifolds and Collective Coordinates

    CERN Document Server

    Papenbrock, T

    2001-01-01

    We introduce suitable coordinate systems for interacting many-body systems with invariant manifolds. These are Cartesian in coordinate and momentum space and chosen such that several components are identically zero for motion on the invariant manifold. In this sense these coordinates are collective. We make a connection to Zickendraht's collective coordinates and present certain configurations of few-body systems where rotations and vibrations decouple from single-particle motion. These configurations do not depend on details of the interaction.

  19. Coordination Processes in International Organisations

    DEFF Research Database (Denmark)

    Nedergaard, Peter

    2008-01-01

    to coordinate relatively elaborate agreements due to the strength of its coordination as far as professional or technical and political activities (excepting the ILO budget) are concerned. In other more clear-cut or 'simple' policy areas such as the ILO budget, the EU coordination is weak: this contrast...

  20. Work Coordination Engine

    Science.gov (United States)

    Zendejas, Silvino; Bui, Tung; Bui, Bach; Malhotra, Shantanu; Chen, Fannie; Kim, Rachel; Allen, Christopher; Luong, Ivy; Chang, George; Sadaqathulla, Syed

    2009-01-01

    The Work Coordination Engine (WCE) is a Java application integrated into the Service Management Database (SMDB), which coordinates the dispatching and monitoring of a work order system. WCE de-queues work orders from SMDB and orchestrates the dispatching of work to a registered set of software worker applications distributed over a set of local, or remote, heterogeneous computing systems. WCE monitors the execution of work orders once dispatched, and accepts the results of the work order by storing to the SMDB persistent store. The software leverages the use of a relational database, Java Messaging System (JMS), and Web Services using Simple Object Access Protocol (SOAP) technologies to implement an efficient work-order dispatching mechanism capable of coordinating the work of multiple computer servers on various platforms working concurrently on different, or similar, types of data or algorithmic processing. Existing (legacy) applications can be wrapped with a proxy object so that no changes to the application are needed to make them available for integration into the work order system as "workers." WCE automatically reschedules work orders that fail to be executed by one server to a different server if available. From initiation to completion, the system manages the execution state of work orders and workers via a well-defined set of events, states, and actions. It allows for configurable work-order execution timeouts by work-order type. This innovation eliminates a current processing bottleneck by providing a highly scalable, distributed work-order system used to quickly generate products needed by the Deep Space Network (DSN) to support space flight operations. WCE is driven by asynchronous messages delivered via JMS indicating the availability of new work or workers. It runs completely unattended in support of the lights-out operations concept in the DSN.

  1. Advice for Coordination

    DEFF Research Database (Denmark)

    Hankin, Chris; Nielson, Flemming; Nielson, Hanne Riis

    2008-01-01

    demanding than the closed joinpoints in more traditional aspect oriented languages like AspectJ. The usefulness of our approach is demonstrated by mechanisms for discretionary and mandatory access control policies, as usually expressed by reference monitors, as well as mechanisms for logging actions.......We show how to extend a coordination language with support for aspect oriented programming. The main challenge is how to properly deal with the trapping of actions before the actual data have been bound to the formal parameters. This necessitates dealing with open joinpoints – which is more...

  2. Markov stochasticity coordinates

    Science.gov (United States)

    Eliazar, Iddo

    2017-01-01

    Markov dynamics constitute one of the most fundamental models of random motion between the states of a system of interest. Markov dynamics have diverse applications in many fields of science and engineering, and are particularly applicable in the context of random motion in networks. In this paper we present a two-dimensional gauging method of the randomness of Markov dynamics. The method-termed Markov Stochasticity Coordinates-is established, discussed, and exemplified. Also, the method is tweaked to quantify the stochasticity of the first-passage-times of Markov dynamics, and the socioeconomic equality and mobility in human societies.

  3. Accelerating coordination in temporal networks by engineering the link order

    Science.gov (United States)

    Masuda, Naoki

    2016-02-01

    Social dynamics on a network may be accelerated or decelerated depending on which pairs of individuals in the network communicate early and which pairs do later. The order with which the links in a given network are sequentially used, which we call the link order, may be a strong determinant of dynamical behaviour on networks, potentially adding a new dimension to effects of temporal networks relative to static networks. Here we study the effect of the link order on linear coordination (i.e., synchronisation) dynamics. We show that the coordination speed considerably depends on specific orders of links. In addition, applying each single link for a long time to ensure strong pairwise coordination before moving to a next pair of individuals does not often enhance coordination of the entire network. We also implement a simple greedy algorithm to optimise the link order in favour of fast coordination.

  4. Developmental coordination disorders: state of art.

    Science.gov (United States)

    Vaivre-Douret, L

    2014-01-01

    In the literature, descriptions of children with motor coordination difficulties and clumsy movements have been discussed since the early 1900s. According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), it is a marked impairment in the development of fine or global motor coordination, affecting 6% of school-age children. All these children are characterized for developmental coordination disorder (DCD) in motor learning and new motor skill acquisition, in contrast to adult apraxia which is a disorder in the execution of already learned movements. No consensus has been established about etiology of DCD. Intragroup approach through factor and cluster analysis highlights that motor impairment in DCD children varies both in severity and nature. Indeed, most studies have used screening measures of performance on some developmental milestones derived from global motor tests. A few studies have investigated different functions together with standardized assessments, such as neuromuscular tone and soft signs, qualitative and quantitative measures related to gross and fine motor coordination and the specific difficulties -academic, language, gnosic, visual motor/visual-perceptual, and attentional/executive- n order to allow a better identification of DCD subtypes with diagnostic criteria and to provide an understanding of the mechanisms and of the cerebral involvement.

  5. Coordination using Implicit Communication

    CERN Document Server

    Cuff, Paul

    2011-01-01

    We explore a basic noise-free signaling scenario where coordination and communication are naturally merged. A random signal X_1,...,X_n is processed to produce a control signal or action sequence A_1,...,A_n, which is observed and further processed (without access to X_1,...,X_n) to produce a third sequence B_1,...,B_n. The object of interest is the set of empirical joint distributions p(x,a,b) that can be achieved in this setting. We show that H(A) >= I(X;A,B) is the necessary and sufficient condition for achieving p(x,a,b) when no causality constraints are enforced on the encoders. We also give results for various causality constraints. This setting sheds light on the embedding of digital information in analog signals, a concept that is exploited in digital watermarking, steganography, cooperative communication, and strategic play in team games such as bridge.

  6. Coordinating Group report

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    In December 1992, western governors and four federal agencies established a Federal Advisory Committee to Develop On-site Innovative Technologies for Environmental Restoration and Waste Management (the DOIT Committee). The purpose of the Committee is to advise the federal government on ways to improve waste cleanup technology development and the cleanup of federal sites in the West. The Committee directed in January 1993 that information be collected from a wide range of potential stakeholders and that innovative technology candidate projects be identified, organized, set in motion, and evaluated to test new partnerships, regulatory approaches, and technologies which will lead to improve site cleanup. Five working groups were organized, one to develop broad project selection and evaluation criteria and four to focus on specific contaminant problems. A Coordinating Group comprised of working group spokesmen and federal and state representatives, was set up to plan and organize the routine functioning of these working groups. The working groups were charged with defining particular contaminant problems; identifying shortcomings in technology development, stakeholder involvement, regulatory review, and commercialization which impede the resolution of these problems; and identifying candidate sites or technologies which could serve as regional innovative demonstration projects to test new approaches to overcome the shortcomings. This report from the Coordinating Group to the DOIT Committee highlights the key findings and opportunities uncovered by these fact-finding working groups. It provides a basis from which recommendations from the DOIT Committee to the federal government can be made. It also includes observations from two public roundtables, one on commercialization and another on regulatory and institutional barriers impeding technology development and cleanup.

  7. Invariant manifolds and collective coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Papenbrock, T. [Centro Internacional de Ciencias, Cuernavaca, Morelos (Mexico); Institute for Nuclear Theory, University of Washington, Seattle, WA (United States); Seligman, T.H. [Centro Internacional de Ciencias, Cuernavaca, Morelos (Mexico); Centro de Ciencias Fisicas, University of Mexico (UNAM), Cuernavaca (Mexico)

    2001-09-14

    We introduce suitable coordinate systems for interacting many-body systems with invariant manifolds. These are Cartesian in coordinate and momentum space and chosen such that several components are identically zero for motion on the invariant manifold. In this sense these coordinates are collective. We make a connection to Zickendraht's collective coordinates and present certain configurations of few-body systems where rotations and vibrations decouple from single-particle motion. These configurations do not depend on details of the interaction. (author)

  8. Coordination Control Of Complex Machines

    NARCIS (Netherlands)

    J.C.M. Baeten; B. van Beek; J. Markovski; L.J.A.M. Somers

    2015-01-01

    Control and coordination are important aspects of the development of complex machines due to an ever-increasing demand for better functionality, quality, and performance. In WP6 of the C4C project, we developed a synthesis-centric systems engineering framework suitable for supervisory coordination o

  9. Coordinate-Free Rotation Operator.

    Science.gov (United States)

    Leubner, C.

    1979-01-01

    Suggests the use of a coordinate-free rotation operator for the teaching of rotations in Euclidean three space because of its twofold didactic advantage. Illustrates the potentialities of the coordinate-free rotation operator approach by a number of examples. (Author/GA)

  10. Coordination of Conditional Poisson Samples

    Directory of Open Access Journals (Sweden)

    Grafström Anton

    2015-12-01

    Full Text Available Sample coordination seeks to maximize or to minimize the overlap of two or more samples. The former is known as positive coordination, and the latter as negative coordination. Positive coordination is mainly used for estimation purposes and to reduce data collection costs. Negative coordination is mainly performed to diminish the response burden of the sampled units. Poisson sampling design with permanent random numbers provides an optimum coordination degree of two or more samples. The size of a Poisson sample is, however, random. Conditional Poisson (CP sampling is a modification of the classical Poisson sampling that produces a fixed-size πps sample. We introduce two methods to coordinate Conditional Poisson samples over time or simultaneously. The first one uses permanent random numbers and the list-sequential implementation of CP sampling. The second method uses a CP sample in the first selection and provides an approximate one in the second selection because the prescribed inclusion probabilities are not respected exactly. The methods are evaluated using the size of the expected sample overlap, and are compared with their competitors using Monte Carlo simulation. The new methods provide a good coordination degree of two samples, close to the performance of Poisson sampling with permanent random numbers.

  11. Project ELI: Improving Early Literacy Outcomes

    Science.gov (United States)

    Young, Robin Miller; Chandler, Lynette K.; Shields, LuAnn; Laubenstein, Pam; Butts, Jill; Black, Kristine

    2008-01-01

    Early childhood and elementary-level educators are engaging in conversations about how to coordinate their efforts to develop fluent readers. There is evidence that key early literacy skills that are predictive of subsequent literacy achievement in kindergarten and first grade can be taught to preschool-age children. Moreover, early childhood…

  12. Social-Perspective Coordination and Gifted Adolescents' Friendship Quality

    Science.gov (United States)

    Masden, Catherine A.; Leung, Olivia N.; Shore, Bruce M.; Schneider, Barry H.; Udvari, Stephen J.

    2015-01-01

    This research examined links among academic ability, social-perspective coordination, and friendship quality, within the context of gifted adolescents' friendships. The sample consisted of 120 early adolescents (59 girls, 61 boys), 81 of whom were identified as gifted. Academic ability, sex, and grade significantly predicted social-perspective…

  13. Chinese geodetic coordinate system 2000

    Institute of Scientific and Technical Information of China (English)

    YANG YuanXi

    2009-01-01

    The basic strategies In establishing the Chinese geodetic coordinate system 2000 have been summarized,including the definition of the coordinate system,the structure of the terrestrial reference frame,the functional and stochastic models involved in the realization of the reference frame as well as the Improvements of the adjustment procedures.First,the fundamental frame of the coordinate system is composed of the permanent GPS tracking network in China which is integrated into the international GPS service stations by combined adjustment,in order to guarantee the consistence between the international terrestrial reference system and the Chinese geodetic coordinate system.Second,the extended frame of the coordinate system is composed of the unified 2000' national GPS network which is Integrated by 6 nationwide GPS networks with more than 2500 stations under the controlling of the fundamental frame.Third,the densified frame is composed of national astronomical geodetic network with nearly 50 thousand stations which was updated by the combined adjustment with the 2000' national GPS network,thus the datum of the national astronomical geodetic network has been unified and the precision greatly improved.By the optimal data fusion method the influences of the datum errors,systematic errors and the outliers in the separated geodetic networks are weakened in the unified Chinese geodetic coordinate frame.The significance in application of the new geodetic coordinate system and the existing problems In the reference frame are described and analyzed.

  14. Keep Meaning in Conversational Coordination

    Directory of Open Access Journals (Sweden)

    Elena Clare Cuffari

    2014-12-01

    Full Text Available Coordination is a widely employed term across recent quantitative and qualitative approaches to intersubjectivity, particularly approaches that give embodiment and enaction central explanatory roles. With a focus on linguistic and bodily coordination in conversational contexts, I review the operational meaning of coordination in recent empirical research and related theorizing of embodied intersubjectivity. This discussion articulates what must be involved in treating linguistic meaning as dynamic processes of coordination. The coordination approach presents languaging as a set of dynamic self-organizing processes and actions on multiple timescales and across multiple modalities that come about and work in certain domains (those jointly constructed in social, interactive, high-order sense-making. These processes go beyond meaning at the level that is available to first-person experience. I take one crucial consequence of this to be the ubiquitously moral nature of languaging with others. Languaging coordinates experience, among other levels of behavior and event. Ethical effort is called for by the automatic autonomy-influencing forces of languaging as coordination.

  15. Toward a theory of coordinating: Creating coordinating mechanisms in practice

    OpenAIRE

    Jarzabkowski, P; Le, J. K.; Feldman, M. S.

    2012-01-01

    This paper uses a practice perspective to study coordinating as dynamic activities that are continuously created and modified in order to enact organizational relationships and activities. It is based on the case of Servico, an organization undergoing a major restructuring of its value chain in response to a change in government regulation. In our case, the actors iterate between the abstract concept of a coordinating mechanism referred to as end-to-end management and its performance in pract...

  16. Evaluating the Relational Coordination instrument

    DEFF Research Database (Denmark)

    Edwards, Kasper; Lundstrøm, Sanne Lykke

    2014-01-01

    and surgical performance. This has prompted the attention of both practitioners and politicians some of who perceive relational coordination as a means to attain better performance. The relational coordination instrument has been validated as a measure of teamwork from the following perspectives: internal...... consistency, interrater agreement and reliability, structural validity, content validity. However as relational coordination is being used as a diagnostics tool it is important to examine further if the instrument can measure changes. Indeed we need to know how precise and sensitive the instrument is when...

  17. 36 CFR 800.8 - Coordination With the National Environmental Policy Act.

    Science.gov (United States)

    2010-07-01

    ... National Environmental Policy Act. 800.8 Section 800.8 Parks, Forests, and Public Property ADVISORY COUNCIL... Coordination With the National Environmental Policy Act. (a) General principles—(1) Early coordination. Federal... steps taken to meet the requirements of the National Environmental Policy Act (NEPA). Agencies...

  18. Social motor coordination in unaffected relatives of schizophrenia patients: A potential intermediate phenotype

    Directory of Open Access Journals (Sweden)

    Jonathan eDel-Monte

    2013-10-01

    Full Text Available Intermediate endophenotypes emerge as an important concept in the study of schizophrenia. Although research on phenotypes mainly investigated cognitive, metabolic or neurophysiological markers so far, some authors also examined the motor behaviour anomalies as potential trait-marker of the disease. However, none of them investigated social motor coordination despite the importance of their anomalies in schizophrenia. The aim of this study was thus to determine whether coordination modifications previously demonstrated in schizophrenia are trait-markers that might be associated with the risk for this pathology. Interpersonal motor coordination in 27 unaffected first-degree relatives of schizophrenia patients and 27 healthy controls was assessed using a hand-held pendulum task to examine the presence of interpersonal coordination impairments in individuals at risk for the disorder. Measures of neurologic soft signs, clinical variables and neurocognitive functions were collected to assess the cognitive and clinical correlates of social coordination impairments in at-risk relatives. After controlling for potential confounding variables, unaffected relatives of schizophrenia patients had impaired intentional interpersonal coordination compared to healthy controls while unintentional interpersonal coordination was preserved. More specifically, in intentional coordination, the unaffected relatives of schizophrenia patients exhibited coordination patterns that had greater variability and in which relatives did not lead the coordination. These results show that unaffected relatives of schizophrenia patients also present deficits in intentional interpersonal coordination. For the first time, these results suggest that intentional interpersonal coordination impairments might be a potential motor intermediate endophenotype of schizophrenia opening new perspectives for early diagnosis.

  19. Coordination Games on Dynamical Networks

    Directory of Open Access Journals (Sweden)

    Enea Pestelacci

    2010-07-01

    Full Text Available We propose a model in which agents of a population interacting according to a network of contacts play games of coordination with each other and can also dynamically break and redirect links to neighbors if they are unsatisfied. As a result, there is co-evolution of strategies in the population and of the graph that represents the network of contacts. We apply the model to the class of pure and general coordination games. For pure coordination games, the networks co-evolve towards the polarization of different strategies. In the case of general coordination games our results show that the possibility of refusing neighbors and choosing different partners increases the success rate of the Pareto-dominant equilibrium.

  20. Ellipsoidal analysis of coordination polyhedra

    Science.gov (United States)

    Cumby, James; Attfield, J. Paul

    2017-02-01

    The idea of the coordination polyhedron is essential to understanding chemical structure. Simple polyhedra in crystalline compounds are often deformed due to structural complexity or electronic instabilities so distortion analysis methods are useful. Here we demonstrate that analysis of the minimum bounding ellipsoid of a coordination polyhedron provides a general method for studying distortion, yielding parameters that are sensitive to various orders in metal oxide examples. Ellipsoidal analysis leads to discovery of a general switching of polyhedral distortions at symmetry-disallowed transitions in perovskites that may evidence underlying coordination bistability, and reveals a weak off-centre `d5 effect' for Fe3+ ions that could be exploited in multiferroics. Separating electronic distortions from intrinsic deformations within the low temperature superstructure of magnetite provides new insights into the charge and trimeron orders. Ellipsoidal analysis can be useful for exploring local structure in many materials such as coordination complexes and frameworks, organometallics and organic molecules.

  1. Fedosov supermanifolds: II. Normal coordinates

    CERN Document Server

    Geyer, B; Geyer, Bodo; Lavrov, Peter

    2004-01-01

    The study of recently introduced Fedosov supermanifolds is continued. Using normal coordinates, properties of even and odd symplectic supermanifolds endowed with a symmetric connection respecting given sympletic structure are studied.

  2. Surface normals and barycentric coordinates

    Directory of Open Access Journals (Sweden)

    Mullineux Glen

    1996-01-01

    Full Text Available The normal to a triangular parametric surface is investigated where the parameters used are barycentric coordinates. Formulae for the normal are obtained for non-rational and rational surfaces.

  3. Some properties of emission coordinates

    CERN Document Server

    Pozo, J M

    2006-01-01

    4 emitters broadcasting an increasing electromagnetic signal generate a system of relativistic coordinates for the space-time, called emission coordinates. Their physical realization requires an apparatus similar to the one of the Global Navigation Satellite Systems (GNSS). Several relativistic corrections are utilized for the current precisions, but the GNSS are conceived as classical (Newtonian) systems, which has deep implications in the way of operating them. The study of emission coordinates is an essential step in order to develop a fully relativistic theory of positioning systems. This talk presents some properties of emission coordinates. In particular, we characterize how any observer sees a configuration of satellites giving a degenerated system and show that the trajectories of the satellites select a unique privileged observer at each point and, for any observer, a set of 3 orthogonal spatial axes.

  4. Kaluza's theory in generalized coordinates

    CERN Document Server

    García-Perciante, A L; García-Colin, L S; Garcia-Perciante, Ana Laura; Sandoval-Villalbazo, Alfredo

    2001-01-01

    Maxwell's equations can be obtained in generalized coordinates by considering the electromagnetic field as an external agent. The work here presented shows how to obtain the electrodynamics for a charged particle in generalized coordinates eliminating the concept of external force. Based on Kaluza's formalism, the one here presented extends the 5x5 metric into a 6x6 space-time giving enough room to include magnetic monopoles in a very natural way.

  5. CPN Models in General Coordinates

    CERN Document Server

    Barnes, K J

    2002-01-01

    An analysis of CPN models is given in terms of general coordinates or arbitrary interpolating fields.Only closed expressions made from simple functions are involved.Special attention is given to CP2 and CP4. In the first of these the retrieval of stereographic coordinates reveals the hermitian form of the metric. A similar analysis for the latter case allows comparison with the Fubini-Study metric.

  6. The Early Childhood Roots of Violence and Non-Violence: What We Can Do.

    Science.gov (United States)

    Marcus, Robert F.

    1999-01-01

    Reviews research concerning the origins of violent behavior in the early childhood years. Discusses the importance of early childhood intervention, and offers recommendations for the coordination of intervention efforts by behavior specialists and early childhood educators. (Author/EV)

  7. Periodic Early Childhood Hearing Screening: The EHDI Perspective

    Science.gov (United States)

    Hoffman, Jeff; Houston, K. Todd; Munoz, Karen F.; Bradham, Tamala S.

    2011-01-01

    State coordinators of early hearing detection and intervention (EHDI) programs completed a strengths, weaknesses, opportunities, and threats, or SWOT, analysis that examined 12 areas within state EHDI programs. Concerning periodic early childhood hearing screening, 47 coordinators listed 241 items and themes were identified within each SWOT…

  8. Conforming to coordinate: children use majority information for peer coordination.

    Science.gov (United States)

    Grueneisen, Sebastian; Wyman, Emily; Tomasello, Michael

    2015-03-01

    Humans are constantly required to coordinate their behaviour with others. As this often relies on everyone's convergence on the same strategy (e.g., driving on the left side of the road), a common solution is to conform to majority behaviour. In this study, we presented 5-year-old children with a coordination problem: To retrieve some rewards, they had to choose the same of four options as a peer partner--in reality a stooge--whose decision they were unable to see. Before making a choice, they watched a video showing how other children from their partner's peer group had behaved; a majority chose the same option and a minority chose a different one. In a control condition, children watched the same video but could then retrieve the reward irrespective of their partner's choice (i.e., no coordination was necessary). Children followed the majority more often when coordination was required. Moreover, conformers mostly justified their choices by referring to the majority from the video demonstration. This study is the first to show that young children are able to strategically coordinate decisions with peers by conforming to the majority.

  9. Werner coordination chemistry and neurodegeneration.

    Science.gov (United States)

    Telpoukhovskaia, Maria A; Orvig, Chris

    2013-02-21

    Neurodegenerative diseases are capturing the world's attention as being the next set of diseases we must tackle collectively. Not only are the patients experiencing gradual cognitive and physical decline in most cases, but these diseases are fatal with no prevention currently available. As these diseases are progressive, providing care and symptom treatment for the ageing population is becoming both a medical and a financial challenge. This review discusses how Werner coordination chemistry plays a role in three diseases - those of Alzheimer's, Parkinson's, and prions. Metal ions are considered to be involved in these diseases in part via their propensity to cause toxic aggregation of proteins. First, the coordination of metal ions, with emphasis on copper(II), to metalloproteins that are hallmarks of these diseases - amyloid β, α-synuclein, and prion, respectively - will be discussed. We will present the current understanding of the metal coordination environments created by the amino acids of these proteins, as well as metal binding affinity. Second, a diverse set of examples of rationally designed metal chelators to outcompete this deleterious binding will be examined based on coordination mode and affinity toward bio-relevant metal ions. Overall, this review will give a general overview of protein and metal chelator coordination environments in neurodegenerative diseases.

  10. Synthetic rubbers prepared by lanthanide coordination catalysts

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    China is rich in rare earth resources. Rare earth elements, also named lanthanides, are number 58 to number 81 elements in the elemental periodic table. They have unique electronic structures and may form various coordination compounds. In the early 1960s, researchers at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CIAC) found the catalytic activities of lanthanide compounds in stereospecific polymerization of conjugated dienes, and published the first paper on this topic in 1964. On the basis of this finding, CIAC launched extensive research activities on lanthanide compounds as diene polymerization catalysts, from a series of fundamental research to the efforts of industrializing the rare earth catalyzed cis-1,4-polybutatine rubber and cis-1,4-polyisoprene rubber. This review aims to summarize the progress in this field in the past half century.

  11. Measurement, coordination, and the relativized a priori

    Science.gov (United States)

    Padovani, Flavia

    2015-11-01

    The problem of measurement is a central issue in the epistemology and methodology of the physical sciences. In recent literature on scientific representation, large emphasis has been put on the "constitutive role" played by measurement procedures as forms of representation. Despite its importance, this issue hardly finds any mention in writings on constitutive principles, viz. in Michael Friedman's account of relativized a priori principles. This issue, instead, was at the heart of Reichenbach's analysis of coordinating principles that has inspired Friedman's interpretation. This paper suggests that these procedures should have a part in an account of constitutive principles of science, and that they could be interpreted following the intuition originally present (but ultimately not fully developed) in Reichenbach's early work.

  12. Synthetic rubbers prepared by lanthanide coordination catalysts

    Institute of Scientific and Technical Information of China (English)

    CHEN WenQi; WANG FoSong

    2009-01-01

    China is rich in rare earth resources. Rare earth elements, also named Ianthanides, are number 58 to number 81 elements in the elemental periodic table. They have unique electronic structures and may form various coordination compounds. In the early 1960s, researchers at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CIAC) found the catalytic activities of lanthanide compounds in stereospecific polymerization of conjugated dienes, and published the first paper on this topic in 1964. On the basis of this finding, CIAC launched extensive research activities on lanthanide compounds as diene polymerization catalysts, from a series of fundamental research to the efforts of industrializing the rare earth catalyzed cis~(-1),4-polybutatine rubber and cis~(-1),4-polyisoprene rubber. This review aims to summarize the progress in this field in the past half century.

  13. COCO: Conversion of Celestial Coordinates

    Science.gov (United States)

    Wallace, Patrick

    2014-06-01

    The COCO program converts star coordinates from one system to another. Both the improved IAU system, post-1976, and the old pre-1976 system are supported. COCO can perform accurate transformations between multiple coordinate systems. COCO's user-interface is spartan but efficient and the program offers control over report resolution. All input is free-format, and defaults are provided where this is meaningful. COCO uses SLALIB (ascl:1403.025) and is distributed as part of the Starlink software collection (ascl:1110.012).

  14. 29 CFR 42.8 - Coordination plan.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Coordination plan. 42.8 Section 42.8 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.8 Coordination plan. (a) Based upon, among other things, the... coordination plan concerning farm labor-related responsibilities of the Department, including migrant...

  15. 33 CFR 165.8 - Geographic coordinates.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Geographic coordinates. 165.8... Geographic coordinates. Geographic coordinates expressed in terms of latitude or longitude, or both, are not... 1983 (NAD 83), unless such geographic coordinates are expressly labeled NAD 83. Geographic...

  16. The Convex Coordinates of the Symmedian Point

    Science.gov (United States)

    Boyd, J. N.; Raychowdhury, P. N.

    2006-01-01

    In this note, we recall the convex (or barycentric) coordinates of the points of a closed triangular region. We relate the convex and trilinear coordinates of the interior points of the triangular region. We use the relationship between convex and trilinear coordinates to calculate the convex coordinates of the symmedian point of the triangular…

  17. 15 CFR 923.56 - Plan coordination.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Plan coordination. 923.56 Section 923... COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Coordination, Public Involvement and National Interest § 923.56 Plan coordination. (a) The management program must be coordinated with local, areawide,...

  18. 40 CFR 109.6 - Coordination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Coordination. 109.6 Section 109.6..., LOCAL AND REGIONAL OIL REMOVAL CONTINGENCY PLANS § 109.6 Coordination. For the purposes of coordination... coordination of these contingency plans with the National Oil and Hazardous Materials Pollution...

  19. 7 CFR 22.201 - Coordination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Coordination. 22.201 Section 22.201 Agriculture Office of the Secretary of Agriculture RURAL DEVELOPMENT COORDINATION Roles and Responsibilities of Federal Government § 22.201 Coordination. The following identifies types and levels of coordination: (a)...

  20. Primary cilia and coordination of signaling pathways in heart development and tissue Homeostasis

    DEFF Research Database (Denmark)

    Clement, Christian Alexandro

    This thesis focuses on cilia and their sensory function in the mammalian organism. In particular, the Hedgehog (Hh) signaling pathway functions via the primary cilium and plays a unique role in development, differentiation, cancer and possibly in stem cell fate. Defects in primary cilia assembly...

  1. Terrestrial Coordinate Systems and Frames

    Science.gov (United States)

    Boucher, C.; Murdin, P.

    2000-11-01

    A terrestrial reference system (TRS) is a spatial reference system corotating with the Earth in its DIURNAL MOTION in space. In such a system, the positions of points anchored on the Earth's solid surface have coordinates which have only small variations with time, as a result of geophysical effects (tectonic or tidal deformations; see TECTONICS, EARTH'S INTERIOR, TIDES). A terrestrial reference ...

  2. Coordinating talk and practical action

    DEFF Research Database (Denmark)

    Oshima, Sae; Streeck, Jürgen

    2015-01-01

    . Our analysis of four examples reveals that there is no fixed relationship between the organization of talk and practical action. Instead, people manipulate this relationship on a moment-by-moment basis, often coordinating the two into a single, integral package, or relying on one stream of action...

  3. Coordinating talk and practical action

    DEFF Research Database (Denmark)

    Oshima, Sae; Streeck, Jürgen

    2015-01-01

    This paper investigates how talk and practical action are coordinated during one type of activity involving professional communication: the service-assessment sequence in hair salons. During this activity, a practical inspection of the haircut must be coupled with sequentially produced verbal act...

  4. Archimedes' Principle in General Coordinates

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is…

  5. Libraries of RGD analogs, labeled through ReO{sup 3+} or TcO{sup 3+} coordination, targeting {alpha}V{beta}3 integrin: development of tracers for the early detection of tumor neo-angiogenesis; Chimiotheques de complexes du technetium et du rhenium ciblant l'integrine {alpha}V{beta}3: developpement de traceurs pour la detection precoce de la neoangiogenese tumorale

    Energy Technology Data Exchange (ETDEWEB)

    Aufort, M.

    2008-11-15

    Integrins form a family of hetero-dimeric integral glycoproteins which play a central role in cell-cell adhesion and cell-matrix interactions. In particular, they are over expressed during tumor neo-angiogenesis. About 10 of them recognize a structured RGD (Arg-Gly-Asp) sequence. Analogs of this sequence can be used for the early detection of tumors and metastases. We developed new tracers, labeled with {sup 99m}Tc, for the molecular imaging of {alpha}{sub V{beta}3} integrin. Until recently, there was no reliable ab initio structure prediction of complex molecules containing Re and Tc chelates. Therefore, we preferred a combinatorial approach to develop potential ligands of {alpha}{sub V{beta}3} integrin and we attempted to identify efficient tracers by in vivo screening. This method would account for biodistribution and pharmacokinetics properties in the early steps of the study. Tracers were obtained according two strategies: i) cyclization of linear RGD analogs; ii) combinatorial assembling of independent modules through metal core coordination by the well-known NS{sub 2}+S motif. After synthesis and labeling, the stability of the tracers was investigated in presence of glutathione and in murine plasma. In vitro screening on purified integrin showed that a cyclic rhenium coordinate binds specifically {alpha}{sub V{beta}3}. A tumor model (U87-MG tumor on nude mice) was validated in the laboratory and a method was developed to analyze in vivo experiments. Biodistribution data and percentage of activity found in tumors are encouraging for cyclic compounds though identification of efficient tracers is difficult due to their instability in the conditions of analyses. (author)

  6. Mechanisms that underlie coordination in children with developmental coordination disorder.

    Science.gov (United States)

    O'Brien, Jane Clifford; Williams, Harriet G; Bundy, Anita; Lyons, Jim; Mittal, Amita

    2008-01-01

    The authors examined potential mechanisms underlying motor coordination in children with developmental coordination disorder (DCD). Because children with DCD experience difficulty processing visual, auditory, and vibrotactile information, the authors explored patterns of choice reaction time (RT) in young (6-7 years) and older (9-10 years) children with and without DCD by using a compatibility-incompatibility paradigm and different sensory modalities. Young children responded more slowly than older children to visual, auditory, and vibrotactile stimuli. Children with DCD took longer than typical children to process visual and vibrotactile stimuli under more complex stimulus-response mappings. Young children with DCD responded more slowly than typical children to visual and vibrotactile information under incompatible conditions. Children with DCD responded faster than unaffected children to auditory stimuli. The results suggest that there is a developmental nature in the processing of visual and auditory input and imply that the vibrotactile sensory modality may be key to the motor coordination difficulties of children with DCD.

  7. Managing Coordinator, Educational or Entrepreneurial Coordinator: Course Coordinator Profile Analysis at Private HEIS

    Directory of Open Access Journals (Sweden)

    Mariana Augusta de Araújo Silva

    2014-12-01

    Full Text Available Higher Education dynamics is impacted by political, economic and financial interference. In parallel, the Ministry of Education and Culture (MEC is strict in its reviews to ensure Brazilian higher education is appreciated and promoted. The purpose of this study is to identify the profile of Course Coordinators and factors that might improve, at the surveyed HEIs, this professional´s relationship with students, teaching staff and Directors. Literature was searched and reviewed so as to collect subject matter pertaining issues. A quantitative research approach was employed and objectives were of exploratory descriptive nature since this technique ensures extended comprehension of the investigated phenomenon, whilst data was gathered via personal interviews. The object of investigation comprised all Course Coordinators of the Estácio/Natal Group in Brazil´s four units. The survey´s tool comprises: 13 closed questions to identify the Coordinator´s profile; 17 questions with a 5 point Likert score scale to identify the entrepreneurial profile; 42 also resorting to a 5 point Likert score scale to measure the dimensions of the Coordinator´s activities and 4 open, optional questions to measure difficulties and possibilities that impact the development of an entrepreneurial course management approach. The study employed both a statistical method (data analysis and descriptive statistics. Findings lead to the conclusion that information and knowledge gathered support researched HEIs in their overcoming of challenges, amongst which encouraging strategic course management and innovation, focused on implementing a new vision of the Course Coordinator, as professionals that master how to balance management and pedagogical skills, whilst innovating by resorting to entrepreneurial competencies.

  8. Porphyrin coordination polymer nanospheres and nanorods

    Science.gov (United States)

    Wang, Zhongchun; Shelnutt, John A.; Medforth, Craig J.

    2012-12-04

    A porphyrin coordination polymer nanostructure comprising a network of pyridyl porphyrin molecules and coordinating metal ions coordinatively bound through the pyridyl groups. In some embodiments, the porphyrins are metalloporphyrins. A variety of nanostructures are formed by the network polymer, including nanospheres, polygonal nanostructures, nanorods, and nanofibers, depending on a variety of factors including coordination metal ion, porphyrin type, metal of the metalloporphyrin, and degree of agitation during nanostructure formation. Reduction of coordinating metal ions may be used to form metal nanoparticles on the coordination polymer nanostructure.

  9. Porphyrin coordination polymer nanospheres and nanorods

    Science.gov (United States)

    Wang, Zhongchun; Shelnutt, John A.; Medforth, Craig J.

    2013-09-10

    A porphyrin coordination polymer nanostructure comprising a network of pyridyl porphyrin molecules and coordinating metal ions coordinatively bound through the pyridyl groups. In some embodiments, the porphyrins are metalloporphyrins. A variety of nanostructures are formed by the network polymer, including nanospheres, polygonal nanostructures, nanorods, and nanofibers, depending on a variety of factors including coordination metal ion, porphyrin type, metal of the metalloporphyrin, and degree of agitation during nanostructure formation. Reduction of coordinating metal ions may be used to form metal nanoparticles on the coordination polymer nanostructure.

  10. A coordination language for databases

    DEFF Research Database (Denmark)

    Li, Ximeng; Wu, Xi; Lluch Lafuente, Alberto

    2016-01-01

    We present a coordination language for the modeling of distributed database applications. The language, baptized Klaim-DB, borrows the concepts of localities and nets of the coordination language Klaim but re-incarnates the tuple spaces of Klaim as databases. It provides high-level abstractions...... and primitives for the access and manipulation of structured data, with integrity and atomicity considerations. We present the formal semantics of Klaim-DB and develop a type system that avoids potential runtime errors such as certain evaluation errors and mismatches of data format in tables, which are monitored...... in the semantics. The use of the language is illustrated in a scenario where the sales from different branches of a chain of department stores are aggregated from their local databases. Raising the abstraction level and encapsulating integrity checks in the language primitives have benefited the modeling task...

  11. Supply Chain Reorganization and Coordination

    Institute of Scientific and Technical Information of China (English)

    WANG Feng-bin

    2001-01-01

    Three generic forms of governance--hierarchy, hybrid and market are proposed in the newinstitutional economics, giving an abstract description of alternative coordination and control mechanisms forgeneral use. While this theory is known as far away from being operational and specified, a few researchersin the management and organization area are trying to extend Galbraith and/or Mintzberg's organizationaldesign theories into the application of logistical coordination for obtaining a smooth flow of products along thesupply chain within and without the focal organization. In this paper, we present an explorative case study onthe design of various organizational architectures of logistics activities and their relevant coordinationmechanisms, especially internal and external contracts as one new kind of hybrid mechanisms forcoordinating effective supply chains.

  12. U.S. CWMD Coordination

    Science.gov (United States)

    2012-12-11

    Biosurveillance Strategy for 68 Human Health in conjunction with the CDC Office of Public Health Preparedness and Response (February 2010). This...Strategy’s goal is to coordinate enhanced nationwide biosurveillance for human health. The term biosurveillance is defined as “managing health-related data...be taken to mitigate adverse health effects” (National Biosurveillance Strategy 5). The practice of biosurveillance seeks to manage data across a

  13. DEVELOPMENTAL COORDINATION DISORDER IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Saeideh MIRAFKHAMI

    2010-04-01

    Full Text Available ObjectiveIn this article, a motor skill disorder called developmental coordination disorder (DCD, that is usually first diagnosed during childhood, is explained and discussed. In the year 1987, DCD was formally recognized as a distinct disorder in children by the American Psychiatric Association  (APA. DCD is a generalized term for the children who have some degrees of impairment in the development of motor coordination and therefore have difficulties with physical skills which significantly interfere with their academic achievements and /or performing everyday activities. As they develop, other age-related tasks are also below average. Because these impairment & conditions are often associated with emotional distress, they can seriously interfere with the person's everyday life and social relationships. Reviews indicate that most of the training rocedures have only a limited effect on the development of general coordination, and that they have no effect at all on academic progress.This includes approaches based on assumed underlying deficiencies such as sensory integration deficits and kinesthetic functioning deficits, as well as the more traditional perceptual - motor training. One new approach is Cognitive Orientation to daily Occupational Performance (CO-OP, based on problem - solving strategies and guided discovery of the child and task specific strategies. The aim of this article was to inform, promote and disseminate more information about some difficulties in applying the diagnostic criteria for DCD. Also, a brief review of the researches on the intervention methods is presented.Keywords: Developmental coordination disorder, Motor skills disorder, Childhood disorder, Intervention methods

  14. Resolution enhancement in tilted coordinates

    Science.gov (United States)

    Hariri Naghadeh, Diako; Keith Morley, Christopher

    2016-11-01

    Deconvolution is applied to remove source wavelet effects from seismograms. The results are resolution enhancement that enables detection of thin layers. Following enhancement of resolution, low frequency and high angle reflectors, particularly at great depth, appear as low amplitude and semi-invisible reflectors that are difficult to track and pick. A new approach to enhance resolution is introduced that estimates a derivative using continuous wavelet transform in tilted coordinates. The results are compared with sparse spike deconvolution, curvelet deconvolution and inverse quality filtering in wavelet domain. The positive consequence of the new method is to increase sampling of high dip features by changing the coordinate system from Cartesian to tilted. To compare those methods a complex data set was chosen that includes high angle faults and chaotic mass transport complex. Image enhancement using curvelet deconvolution shows a chaotic system as a non-chaotic one. The results show that sparse spike deconvolution and inverse quality filtering in wavelet domain are able to enhance resolution more than curvelet deconvolution especially at great depth but it is impossible to follow steep dip reflectors after resolution enhancement using these methods, especially when their apparent dips are more than 45°. By estimating derivatives in a continuous wavelet transform from tilted data sets similar resolution enhancement as the other deconvolution methods is achieved but additionally steep dipping reflectors are imaged much better than others. Subtracted results of the enhanced resolution data set using new method and the other introduced methods show that steeply dipping reflectors are highlighted as a particular ability of the new method. The results show that high frequency recovery in Cartesian co-ordinate is accompanied by inability to image steeply dipping reflectors especially at great depths. Conversely recovery of high frequency data and imaging of the data

  15. Coordination strategies of crew management

    Science.gov (United States)

    Conley, Sharon; Cano, Yvonne; Bryant, Don

    1991-01-01

    An exploratory study that describes and contrasts two three-person flight crews performing in a B-727 simulator is presented. This study specifically attempts to delineate crew communication patterns accounting for measured differences in performance across routine and nonroutine flight patterns. The communication patterns in the two crews evaluated indicated different modes of coordination, i.e., standardization in the less effective crew and planning/mutual adjustment in the more effective crew.

  16. DEVELOPMENTAL COORDINATION DISORDER IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Saeideh MIRAFKHAMI

    2010-03-01

    Full Text Available ObjectiveIn this article, a motor skill disorder called developmental coordination disorder (DCD, that is usually first diagnosed during childhood, is explained and discussed. In the year 1987, DCD was formally recognized as a distinct disorder in children by the American Psychiatric Association (APA. DCD is a generalized term for the children who have some degrees of impairment in the development of motor coordination and therefore have difficulties with physical skills which significantly interfere with their academic achievements and /or performing everyday activities. As they develop, other age-related tasks are also below average. Because these impairment & conditions are often associated with emotional distress, they can seriously interfere with the person's everyday life and social relationships. Reviews indicate that most of the training rocedures have only a limited effect on the development of general coordination, and that they have no effect at all on academic progress.This includes approaches based on assumed underlying deficiencies such as sensory integration deficits and kinesthetic functioning deficits, as well as the more traditional perceptual - motor training. One new approach is Cognitive Orientation to daily Occupational Performance (CO-OP, based on problem - solving strategies and guided discovery of the child and task specific strategies. The aim of this article was to inform, promote and disseminate more information about some difficulties in applying the diagnostic criteria for DCD. Also, a brief review of the researches on the intervention methods is presented.

  17. Coordinate unsaturation with fluorinated ligands

    Energy Technology Data Exchange (ETDEWEB)

    Rack, J.L.; Hurlburt, P.K.; Anderson, O.P.; Strauss, S.H. [Colorado State Univ., Ft. Collins, CO (United States)

    1993-12-31

    The preparation and characterization of Zn(OTeF{sub 5}){sub 2} has resulted in a model compound with which to explore the concept of coordinative unsaturation. The coordination of solvents of varying donicity and dielectric constant to the Zn(II) ions in Zn(OTeF{sub 5}){sub 2} was studied by vapor phase monometry, NMR and IR spectroscopy, conductimetry, and X-Ray crystallography. The structures of [Zn(C{sub 6}H{sub 5}NO{sub 2}){sub 2}(OTeF{sub 5})2]2 and Zn(C{sub 6}H{sub 5}NO{sub 2}){sub 3}(OTEF{sub 5}){sub 2} demonstrate the electronic flexibility of some weakly coordinating solvents in that nitrobenzene can function as either an {eta}{sup 1}O or {eta}{sup 2}O,O`-ligand. The dependence of the number of bound solvent molecules and the degree of OTeF{sub 5}{minus} dissociation on solvent donor number and dielectric constant will be presented.

  18. Periodic behavior of lanthanide coordination within reverse micelles.

    Science.gov (United States)

    Ellis, Ross J; Meridiano, Yannick; Chiarizia, Renato; Berthon, Laurence; Muller, Julie; Couston, Laurent; Antonio, Mark R

    2013-02-18

    Trends in lanthanide(III) (Ln(III)) coordination were investigated within nanoconfined solvation environments. Ln(III) ions were incorporated into the cores of reverse micelles (RMs) formed with malonamide amphiphiles in n-heptane by contact with aqueous phases containing nitrate and Ln(III); both insert into pre-organized RM units built up of DMDOHEMA (N,N'-dimethyl-N,N'-dioctylhexylethoxymalonamide) that are either relatively large and hydrated or small and dry, depending on whether the organic phase is acidic or neutral, respectively. Structural aspects of the Ln(III) complex formation and the RM morphology were obtained by use of XAS (X-ray absorption spectroscopy) and SAXS (small-angle X-ray scattering). The Ln(III) coordination environments were determined through use of L(3)-edge XANES (X-ray absorption near edge structure) and EXAFS (extended X-ray absorption fine structure), which provide metrical insights into the chemistry across the period. Hydration numbers for the Eu species were measured using TRLIFS (time-resolved laser-induced fluorescence spectroscopy). The picture that emerges from a system-wide perspective of the Ln-O interatomic distances and number of coordinating oxygen atoms for the extracted complexes of Ln(III) in the first half of the series (i.e., Nd, Eu) is that they are different from those in the second half of the series (i.e., Tb, Yb): the number of coordinating oxygen atoms decrease from 9O for early lanthanides to 8O for the late ones--a trend that is consistent with the effect of the lanthanide contraction. The environment within the RM, altered by either the presence or absence of acid, also had a pronounced influence on the nitrate coordination mode; for example, the larger, more hydrated, acidic RM core favors monodentate coordination, whereas the small, dry, neutral core favors bidentate coordination to Ln(III). These findings show that the coordination chemistry of lanthanides within nanoconfined environments is neither

  19. Energy shaping for coordinating internally actuated vehicles

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    This paper considers the stable coordination problem of two vehicles equipping with internal moving mass actuators.The coordinating and stabilizing control are derived by energy shaping. The proposed method is physically motivated and avoids cancelation or domination of nonlinearities.

  20. Noncommuting Coordinates in the Landau Problem

    OpenAIRE

    Magro, Gabrielle

    2003-01-01

    Basic ideas about noncommuting coordinates are summarized, and then coordinate noncommutativity, as it arises in the Landau problem, is investigated. I review a quantum solution to the Landau problem, and evaluate the coordinate commutator in a truncated state space of Landau levels. Restriction to the lowest Landau level reproduces the well known commutator of planar coordinates. Inclusion of a finite number of Landau levels yields a matrix generalization.

  1. Development of the Little Developmental Coordination Disorder Questionnaire for Preschoolers and Preliminary Evidence of Its Psychometric Properties in Israel

    Science.gov (United States)

    Rihtman, Tanya; Wilson, Brenda N.; Parush, Shula

    2011-01-01

    Purpose: The early identification of motor coordination challenges before school age may enable close monitoring of a child's development and perhaps ameliorate some of the social, psychological and behavioral sequela that often accompany unrecognized Developmental Coordination Disorder (DCD). The purpose of this study was to develop and assess…

  2. Implementation of the Integrated Early Childhood Policy in Senegal. Early Childhood and Family Policy Series.

    Science.gov (United States)

    Rayna, Sylvie

    As part of a UNESCO-sponsored series of studies examining how integrated and coordinated early childhood policies are implemented, this case study focuses on Senegal's integrated early childhood policy. The case study examines the context for policy development and analyzes the structure and resources of the Ministry for the Family and Early…

  3. Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish.

    Science.gov (United States)

    Raghupathy, Rakesh K; Zhang, Xun; Alhasani, Reem H; Zhou, Xinzhi; Mullin, Margaret; Reilly, James; Li, Wenchang; Liu, Mugen; Shu, Xinhua

    2016-08-01

    Photoreceptors are highly specialized sensory neurons that possess a modified primary cilium called the outer segment. Photoreceptor outer segment formation and maintenance require highly active protein transport via a process known as intraflagellar transport. Anterograde transport in outer segments is powered by the heterotrimeric kinesin II and coordinated by intraflagellar transport proteins. Here, we describe a new zebrafish model carrying a nonsense mutation in the kinesin II family member 3A (kif3a) gene. Kif3a mutant zebrafish exhibited curved body axes and kidney cysts. Outer segments were not formed in most parts of the mutant retina, and rhodopsin was mislocalized, suggesting KIF3A has a role in rhodopsin trafficking. Both rod and cone photoreceptors degenerated rapidly between 4 and 9 days post fertilization, and electroretinography response was not detected in 7 days post fertilization mutant larvae. Loss of KIF3A in zebrafish also resulted in an intracellular transport defect affecting anterograde but not retrograde transport of organelles. Our results indicate KIF3A plays a conserved role in photoreceptor outer segment formation and intracellular transport.

  4. 45 CFR 1310.23 - Coordinated transportation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Coordinated transportation. 1310.23 Section 1310... START PROGRAM HEAD START TRANSPORTATION Special Requirements § 1310.23 Coordinated transportation. (a) Each agency providing transportation services must make reasonable efforts to coordinate...

  5. 45 CFR 98.82 - Coordination.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Coordination. 98.82 Section 98.82 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND Indian Tribes § 98.82 Coordination. Tribal applicants shall coordinate as required by §§ 98.12 and 98.14 and: (a)...

  6. Managing interteam coordination within and between organizations

    NARCIS (Netherlands)

    de Vries, Thomas Arend

    2015-01-01

    To accomplish complex tasks and effectively respond to environmental contingencies, teams must coordinate task-related issues with other teams (i.e., interteam coordination). Regrettably, interteam coordination is often complicated by misunderstandings that can arise from differences in teams’ langu

  7. 36 CFR 13.1104 - Coordinates.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Coordinates. 13.1104 Section 13.1104 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR... Administrative Provisions § 13.1104 Coordinates. All coordinates referenced in this subpart use horizontal...

  8. 33 CFR 166.103 - Geographic coordinates.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Geographic coordinates. 166.103...) PORTS AND WATERWAYS SAFETY SHIPPING SAFETY FAIRWAYS General § 166.103 Geographic coordinates. Geographic coordinates expressed in terms of latitude or longitude, or both, are not intended for plotting on maps...

  9. 33 CFR 167.3 - Geographic coordinates.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Geographic coordinates. 167.3...) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES General § 167.3 Geographic coordinates. Geographic coordinates are defined using North American 1927 Datum (NAD 27) unless indicated otherwise....

  10. Construction and minimality of coordinated linear systems

    NARCIS (Netherlands)

    Kempker, P.L.; Ran, A.C.M.; Schuppen, J.H. van

    2014-01-01

    Coordinated linear systems are a particular class of hierarchical systems with a top-to-bottom information structure, consisting of a coordinator system and two or more subsystems. This paper deals with the construction and minimality of coordinated linear systems. Construction procedures are given

  11. 7 CFR 23.3 - Coordination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Coordination. 23.3 Section 23.3 Agriculture Office of the Secretary of Agriculture STATE AND REGIONAL ANNUAL PLANS OF WORK State Program § 23.3 Coordination... designate an official who will be responsible for the overall coordination of the authorized programs...

  12. 47 CFR 74.638 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... frequency coordinated under this paragraph, the interference protection criteria in 47 CFR 101.105(a), (b), and (c) and the frequency usage coordination procedures in 47 CFR 101.103(d) will apply. (c) For each... 47 Telecommunication 4 2010-10-01 2010-10-01 false Frequency coordination. 74.638 Section...

  13. 47 CFR 87.305 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequency coordination. 87.305 Section 87.305... Flight Test Stations § 87.305 Frequency coordination. (a)(1) Each application for a new station license... prior coordinations and assignments on the proposed frequency(ies). The committee must also...

  14. 49 CFR 214.325 - Train coordination.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Train coordination. 214.325 Section 214.325..., DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.325 Train coordination. Working limits established by a roadway worker through the use of train coordination shall comply with...

  15. Coordination in serial-parallel image processing

    Science.gov (United States)

    Wójcik, Waldemar; Dubovoi, Vladymyr M.; Duda, Marina E.; Romaniuk, Ryszard S.; Yesmakhanova, Laura; Kozbakova, Ainur

    2015-12-01

    Serial-parallel systems used to convert the image. The control of their work results with the need to solve coordination problem. The paper summarizes the model of coordination of resource allocation in relation to the task of synchronizing parallel processes; the genetic algorithm of coordination developed, its adequacy verified in relation to the process of parallel image processing.

  16. 77 FR 778 - Council Coordination Committee Meeting

    Science.gov (United States)

    2012-01-06

    ... National Oceanic and Atmospheric Administration RIN 0648-XA918 Council Coordination Committee Meeting...), Commerce. ACTION: Notice of a public meeting. SUMMARY: NMFS will host a meeting of the Council Coordination... Reauthorization Act (MSRA) of 2006 established the Council Coordination Committee by amending Section 302 (16...

  17. Is fiscal policy coordination in EMU desirable?

    NARCIS (Netherlands)

    R.M.W.J. Beetsma; X. Debrun; F.J.G.M. Klaassen

    2001-01-01

    'It is widely argued that Europe's unified monetary policy calls for international coordination of fiscal policy. This paper surveys the issues involved with the coordination of fiscal policies as a demand management tool. We discuss ex-ante and ex-post coordination. The former operates through bind

  18. Rhythms of dialogue in infancy: coordinated timing in development.

    Science.gov (United States)

    Jaffe, J; Beebe, B; Feldstein, S; Crown, C L; Jasnow, M D

    2001-01-01

    Although theories of early social development emphasize the advantage of mother-infant rhythmic coupling and bidirectional coordination, empirical demonstrations remain sparse. We therefore test the hypothesis that vocal rhythm coordination at age 4 months predicts attachment and cognition at age 12 months. Partner and site novelty were studied by recording mother-infant, stranger-infant, and mother-stranger face-to-face interactions in both home and laboratory sites for 88 4-month-old infants, for a total of 410 recordings. An automated dialogic coding scheme, appropriate to the nonperiodic rhythms of our data, implemented a systems concept of every action as jointly produced by both partners. Adult-infant coordination at age 4 months indeed predicted both outcomes at age 12 months, but midrange degree of mother-infant and stranger-infant coordination was optimal for attachment (Strange Situation), whereas high ("tight") stranger-infant coordination in the lab was optimal for cognition (Bayley Scales). Thus, high coordination can index more or less optimal outcomes, as a function of outcome measure, partner, and site. Bidirectional coordination patterns were salient in both attachment and cognition predictions. Comparison of mother-infant and stranger-infant interactions was particularly informative, suggesting the dynamics of infants' early differentiation from mothers. Stranger and infant showed different patterns of vocal rhythm activity level, were more bidirectional, accounted for 8 times more variance in Bayley scores, predicted attachment just as well as mother and infant, and revealed more varied contingency structures and a wider range of attachment outcomes. To explain why vocal timing measures at age 4 months predict outcomes at age 12 months, our dialogue model was construed as containing procedures for regulating the pragmatics of proto-conversation. The timing patterns of the 4-month-olds were seen as procedural or performance knowledge, and as

  19. Application coordination in pervasive systems

    CERN Document Server

    Majuntke, Verena Elisabeth

    2013-01-01

    Pervasive applications are designed to support users in their daily life. For this purpose, applications interact with their environment, i.e. their context. They are able to adapt themselves to context changes or to explicitly change the context via actuators. If multiple applications are executed in the same context, interferences are likely to occur. To manage interferences, a coordination framework is presented in this thesis. Interferences are detected using a context model and information about applications' interaction with the context. The resolution of interference is achieved through

  20. Coordinated hybrid automatic repeat request

    KAUST Repository

    Makki, Behrooz

    2014-11-01

    We develop a coordinated hybrid automatic repeat request (HARQ) approach. With the proposed scheme, if a user message is correctly decoded in the first HARQ rounds, its spectrum is allocated to other users, to improve the network outage probability and the users\\' fairness. The results, which are obtained for single- and multiple-antenna setups, demonstrate the efficiency of the proposed approach in different conditions. For instance, with a maximum of M retransmissions and single transmit/receive antennas, the diversity gain of a user increases from M to (J+1)(M-1)+1 where J is the number of users helping that user.

  1. Neurological impairment in nephropathic cystinosis: motor coordination deficits.

    Science.gov (United States)

    Trauner, Doris A; Williams, Jennifer; Ballantyne, Angela O; Spilkin, Amy M; Crowhurst, Jennifer; Hesselink, John

    2010-10-01

    Nephropathic cystinosis is a rare genetic metabolic disorder that results in accumulation of the amino acid cystine in lysosomes due to lack of a cystine-specific transporter protein. Cystine accumulates in cells throughout the body and causes progressive damage to multiple organs, including the brain. Neuromotor deficits have been qualitatively described in individuals with cystinosis. This study quantitatively examined fine-motor coordination in individuals with cystinosis. Brain magnetic resonance imaging (MRI) scans were also performed to determine whether structural changes were associated with motor deficits. Participants were 52 children and adolescents with infantile nephropathic cystinosis and 49 controls, ages 2-17 years, divided into preacademic and school-age groups. Results indicated that both the preacademic and school-age cystinosis groups performed significantly more poorly than their matched control groups on the Motor Coordination Test. Further, the level of performance was not significantly different between the preacademic and school-age groups. There were no significant differences in motor coordination scores based on MRI findings. This is the first study to document a persistent, nonprogressive, fine-motor coordination deficit in children and adolescents with cystinosis. The fact that these difficulties are present in the preschool years lends further support to the theory that cystinosis adversely affects neurological functioning early in development. The absence of a relationship between brain structural changes and motor function suggests that an alternative cause for motor dysfunction must be at work in this disorder.

  2. Harmonic Vibrational Analysis in Delocalized Internal Coordinates.

    Science.gov (United States)

    Jensen, Frank; Palmer, David S

    2011-01-11

    It is shown that a principal component analysis of a large set of internal coordinates can be used to define a nonredundant set of delocalized internal coordinates suitable for the calculation of harmonic vibrational normal modes. The selection of internal coordinates and the principal component analysis provide large degrees of freedom in extracting a nonredundant set of coordinates, and thus influence how the vibrational normal modes are described. It is shown that long-range coordinates may be especially suitable for describing low-frequency global deformation modes in proteins.

  3. Unpacking Coordination Benefits in Supply Networks

    DEFF Research Database (Denmark)

    Petrick, Irene J.; Maitland, Carleen; Pogrebnyakov, Nicolai

    2016-01-01

    This paper examines how coordination among firms in supply networks generates benefits in the short and long terms for firms. It focuses on information technology (IT) and process improvement coordination. Analysis was performed on quantitative and qualitative data from a sample of SMEs in plastics...... manufacturing in Pennsylvania. Results indicate that coordination on both IT and process improvement leads to short- and long-term benefits. These relationships were mediated by the adoption of innovations (when coordinating on IT) and access to new capabilities (in process improvement coordination......). These results extend the understanding of how participation in supply networks benefits individual firms....

  4. Ytterbium Coordination Polymer with Four Different Coordination Numbers: The First Structural Characterization of Lanthanide Phthalate Complex

    Institute of Scientific and Technical Information of China (English)

    WAN,Yong-Hong(万永红); JIN,Lin-Pei(金林培); WANG,Ke-Zhi(王科志)

    2002-01-01

    The novel ytterbium coordination polymer is a two-dimensional framework in which the central metal ions have four different coordination numhers and form four kinds of coordination polyhedra. The four kinds of coordination polyhedra connect into infinite chains by sharing oxygen atoms

  5. D Coordinate Transformation Using Artificial Neural Networks

    Science.gov (United States)

    Konakoglu, B.; Cakır, L.; Gökalp, E.

    2016-10-01

    Two coordinate systems used in Turkey, namely the ED50 (European Datum 1950) and ITRF96 (International Terrestrial Reference Frame 1996) coordinate systems. In most cases, it is necessary to conduct transformation from one coordinate system to another. The artificial neural network (ANN) is a new method for coordinate transformation. One of the biggest advantages of the ANN is that it can determine the relationship between two coordinate systems without a mathematical model. The aim of this study was to investigate the performances of three different ANN models (Feed Forward Back Propagation (FFBP), Cascade Forward Back Propagation (CFBP) and Radial Basis Function Neural Network (RBFNN)) with regard to 2D coordinate transformation. To do this, three data sets were used for the same study area, the city of Trabzon. The coordinates of data sets were measured in the ED50 and ITRF96 coordinate systems by using RTK-GPS technique. Performance of each transformation method was investigated by using the coordinate differences between the known and estimated coordinates. The results showed that the ANN algorithms can be used for 2D coordinate transformation in cases where optimum model parameters are selected.

  6. Early Stimulation: A Joint Project Between Parents and Teachers.

    Science.gov (United States)

    Gomez, Aminta J. Da Costa

    The coordinator of an early stimulation program for handicapped children in Curacao describes the program in terms of home teaching, use of the Portage Project curriculum, and the importance of parent-professional cooperation. (CL)

  7. Early clerkships

    NARCIS (Netherlands)

    Kamalski, Digna M. A.; Ter Braak, Edith W. M. T.; Ten Cate, Olle Th. J.; Borleffs, Jan C. C.

    2007-01-01

    Background: Early clinical experience is being introduced in innovative, vertically integrated undergraduate medical curricula. While in many cases, this early clinical experience is limited to the presence of patients during lectures, in Utrecht students gain 'hands on' experience of daily clinical

  8. Coordination Chemistry of Microbial Iron Transport.

    Science.gov (United States)

    Raymond, Kenneth N; Allred, Benjamin E; Sia, Allyson K

    2015-09-15

    This Account focuses on the coordination chemistry of the microbial iron chelators called siderophores. The initial research (early 1970s) focused on simple analogs of siderophores, which included hydroxamate, catecholate, or hydroxycarboxylate ligands. The subsequent work increasingly focused on the transport of siderophores and their microbial iron transport. Since these are pseudo-octahedral complexes often composed of bidentate ligands, there is chirality at the metal center that in principle is independent of the ligand chirality. It has been shown in many cases that chiral recognition of the complex occurs. Many techniques have been used to elucidate the iron uptake processes in both Gram-positive (single membrane) and Gram-negative (double membrane) bacteria. These have included the use of radioactive labels (of ligand, metal, or both), kinetically inert metal complexes, and Mössbauer spectroscopy. In general, siderophore recognition and transport involves receptors that recognize the metal chelate portion of the iron-siderophore complex. A second, to date less commonly found, mechanism called the siderophore shuttle involves the receptor binding an apo-siderophore. Since one of the primary ways that microbes compete with each other for iron stores is the strength of their competing siderophore complexes, it became important early on to characterize the solution thermodynamics of these species. Since the acidity of siderophores varies significantly, just the stability constant does not give a direct measure of the relative competitive strength of binding. For this reason, the pM value is compared. The pM, like pH, is a measure of the negative log of the free metal ion concentration, typically calculated at pH 7.4, and standard total concentrations of metal and ligand. The characterization of the electronic structure of ferric siderophores has done much to help explain the high stability of these complexes. A new chapter in siderophore science has emerged

  9. Impairments of social motor coordination in schizophrenia.

    Directory of Open Access Journals (Sweden)

    Manuel Varlet

    Full Text Available It has been demonstrated that motor coordination of interacting people plays a crucial role in the success of social exchanges. Abnormal movements have been reported during interpersonal interactions of patients suffering from schizophrenia and a motor coordination breakdown could explain this social interaction deficit, which is one of the main and earliest features of the illness. Using the dynamical systems framework, the goal of the current study was (i to investigate whether social motor coordination is impaired in schizophrenia and (ii to determine the underlying perceptual or cognitive processes that may be affected. We examined intentional and unintentional social motor coordination in participants oscillating hand-held pendulums from the wrist. The control group consisted of twenty healthy participant pairs while the experimental group consisted of twenty participant pairs that included one participant suffering from schizophrenia. The results showed that unintentional social motor coordination was preserved while intentional social motor coordination was impaired. In intentional coordination, the schizophrenia group displayed coordination patterns that had lower stability and in which the patient never led the coordination. A coupled oscillator model suggests that the schizophrenia group coordination pattern was due to a decrease in the amount of available information together with a delay in information transmission. Our study thus identified relational motor signatures of schizophrenia and opens new perspectives for detecting the illness and improving social interactions of patients.

  10. Tree Formation Using Coordinate Method

    Directory of Open Access Journals (Sweden)

    Monika Choudhary

    2015-06-01

    Full Text Available In this paper we are introducing a new method of tree formation, we propose a coordinate based method by which we can store and access tree structures. As we know in NLP, parsing is the most important module. The output of this module is generally parsed trees. Currently, TAG (Tree Adjoining Grammar is widely used grammar due to its linguistic and formal nature. It is simply tree generating system. The unit structure used in TAG is structured trees. So we used our new method to store trees where we worked on English to Hindi language. We worked on different sentences from English to Hindi, our method is the easiest way to manipulate tree. We have implemented within small corpus and for finite number of structures and further can be extended in future.

  11. Coordination Frictions and Job Heterogeneity

    DEFF Research Database (Denmark)

    Kennes, John; le Maire, Christian Daniel

    This paper develops and extends a dynamic, discrete time, job to worker matching model in which jobs are heterogeneous in equilibrium. The key assumptions of this economic environment are (i) matching is directed and (ii) coordination frictions lead to heterogeneous local labor markets. We de- rive...... a number of new theoretical results, which are essential for the empirical application of this type of model to matched employer-employee microdata. First, we o¤er a robust equilibrium concept in which there is a continu- ous dispersion of job productivities and wages. Second, we show that our model can...... be readily solved with continuous exogenous worker heterogene- ity, where high type workers (high outside options and productivity) earn higher wages in high type jobs and are hired at least as frequently to the better job types as low type workers (low outside options and productivity). Third, we...

  12. Coordination control of distributed systems

    CERN Document Server

    Villa, Tiziano

    2015-01-01

    This book describes how control of distributed systems can be advanced by an integration of control, communication, and computation. The global control objectives are met by judicious combinations of local and nonlocal observations taking advantage of various forms of communication exchanges between distributed controllers. Control architectures are considered according to  increasing degrees of cooperation of local controllers:  fully distributed or decentralized control,  control with communication between controllers,  coordination control, and multilevel control.  The book covers also topics bridging computer science, communication, and control, like communication for control of networks, average consensus for distributed systems, and modeling and verification of discrete and of hybrid systems. Examples and case studies are introduced in the first part of the text and developed throughout the book. They include: control of underwater vehicles, automated-guided vehicles on a container terminal, contro...

  13. Coordinated Exploration for Grand Challenges

    DEFF Research Database (Denmark)

    Ørding Olsen, Anders; Sofka, Wolfgang; Grimpe, Christoph

    2016-01-01

    Grand challenges are among the most complex problems for modern societies. Many governments and foundations provide substantial resources to encourage the search for solutions. Due to the significance of these problems, organizations often form partnerships in what we call search consortia...... to engage in joint search and compete for funding. Prior research on joint search highlights the role of specialized organizations, mainly regarding technological domains, to identify a superior solution. However, stakeholder theory leads us to believe that the success of any solution depends...... on the acceptance and support of important stakeholders. In this study, we suggest that search consortia are more likely to receive funding when they include representatives of stakeholder concerns, so-called advocacy groups. We extend theory on coordinated exploration in joint search by integrating mechanisms from...

  14. A framework of manufacturer-retailer coordination process

    DEFF Research Database (Denmark)

    Wong, Chee Yew; Johansen, John

    2008-01-01

    there was disagreement. Third, closer mode of coordination, which involved joint evaluation and derivation of coordination solutions, reduced the numbers of iterative coordination cycles. These empirical findings verified the presupposed framework of coordination process. Research limitations/implications - Three...

  15. Characteristics of Trivalent Lanthanides in Coordination Chemistry

    Institute of Scientific and Technical Information of China (English)

    Xue Dongfeng(薛冬峰); Zuo Sen(左森); Henryk Ratajczak

    2004-01-01

    Some basic characteristics of lanthanide-oxygen bonds in various trivalent lanthanide metal-organic complexes are quantitatively studied by the bond valence model. Some important relationships among the electronegativity, bond valence parameter, bond length and lanthanide coordination number in these complexes are generally found , which show that for each trivalent lanthanide cation all calculated parameters may well be correlated with its coordination number in their coordination complexes. Specifically,32 new data for the bond valence parameter are first calculated in this work.An approximate linear relationship between the Ln-O bond valence parameter and the coordination number of Ln3+ is obtained.The Ln-O bond length increases with the increase in the lanthanide coordination number.The difference of electronegative values decreases with the increase in the lanthanide coordination number.

  16. Control coordination abilities in shock combat sports

    Directory of Open Access Journals (Sweden)

    Natalya Boychenko

    2014-12-01

    Full Text Available Purpose: optimize the process control level of coordination abilities in martial arts. Material and Methods: analysis and compilation of scientific and methodological literature, interviews with coaches of drum martial arts, video analysis techniques, teacher observations. Results: identified specific types of coordination abilities in shock combat sports. Pod branny and offered specific and nonspecific tests to monitor the level of species athletes coordination abilities. Conclusion: it is determined that in order to achieve victory in the fight martial artists to navigate the space to be able to assess and manage dynamic and spatio-temporal parameters of movements, maintain balance, have a high coordination of movements. The proposed tests to monitor species coordination abilities athletes allow an objective assessment of not only the overall level of coordination, and the level of specific types of manifestations of this ability.

  17. Reaction Coordinates and Mechanistic Hypothesis Tests.

    Science.gov (United States)

    Peters, Baron

    2016-05-27

    Reaction coordinates are integral to several classic rate theories that can (a) predict kinetic trends across conditions and homologous reactions, (b) extract activation parameters with a clear physical interpretation from experimental rates, and (c) enable efficient calculations of free energy barriers and rates. New trajectory-based rare events methods can provide rates directly from dynamical trajectories without a reaction coordinate. Trajectory-based frameworks can also generate ideal (but abstract) reaction coordinates such as committors and eigenfunctions of the master equation. However, rates and mechanistic insights obtained from trajectory-based methods and abstract coordinates are not readily generalized across simulation conditions or reaction families. We discuss methods for identifying physically meaningful reaction coordinates, including committor analysis, variational transition state theory, Kramers-Langer-Berezhkovskii-Szabo theory, and statistical inference methods that can use path sampling data to screen, mix, and optimize thousands of trial coordinates. Special focus is given to likelihood maximization and inertial likelihood maximization approaches.

  18. Reaction Coordinates and Mechanistic Hypothesis Tests

    Science.gov (United States)

    Peters, Baron

    2016-05-01

    Reaction coordinates are integral to several classic rate theories that can (a) predict kinetic trends across conditions and homologous reactions, (b) extract activation parameters with a clear physical interpretation from experimental rates, and (c) enable efficient calculations of free energy barriers and rates. New trajectory-based rare events methods can provide rates directly from dynamical trajectories without a reaction coordinate. Trajectory-based frameworks can also generate ideal (but abstract) reaction coordinates such as committors and eigenfunctions of the master equation. However, rates and mechanistic insights obtained from trajectory-based methods and abstract coordinates are not readily generalized across simulation conditions or reaction families. We discuss methods for identifying physically meaningful reaction coordinates, including committor analysis, variational transition state theory, Kramers-Langer-Berezhkovskii-Szabo theory, and statistical inference methods that can use path sampling data to screen, mix, and optimize thousands of trial coordinates. Special focus is given to likelihood maximization and inertial likelihood maximization approaches.

  19. Increased coordination in public transport – which mechanisms are available?

    DEFF Research Database (Denmark)

    Sørensen, Claus Hedegaard; Longva, Frode

    2011-01-01

    After several years of New Public Management reforms within public transport, coordination seems to receive increased attention. With examples of actual as well as suggested changes taken from Denmark, Sweden and the UK the aim of the article is to analyse and classify the mechanisms utilized...... and suggested to increase coordination between core stakeholders within passenger railway services and bus services. Four distinctive mechanisms of coordination are suggested, namely organisational coordination, contractual coordination, partnership coordination and discursive coordination. Each coordination...

  20. Convergence of barycentric coordinates to barycentric kernels

    KAUST Repository

    Kosinka, Jiří

    2016-02-12

    We investigate the close correspondence between barycentric coordinates and barycentric kernels from the point of view of the limit process when finer and finer polygons converge to a smooth convex domain. We show that any barycentric kernel is the limit of a set of barycentric coordinates and prove that the convergence rate is quadratic. Our convergence analysis extends naturally to barycentric interpolants and mappings induced by barycentric coordinates and kernels. We verify our theoretical convergence results numerically on several examples.

  1. Novel Coordination Chemistry of Aluminum Borohydride

    Science.gov (United States)

    2014-08-01

    four different crystal shapes were identified under a microscope.  Super thin plates are not a preferred crystal shape for X-ray analysis. Anion ...coordination of various ligands. Previously we investigated an IL based upon the [Al(BH4)4]- anion . This material showed a much improved air and...moisture stability compared to ABH. Here we present research on the coordination of the cyanoborohydride anion (NCBH3-) with ABH. The coordination

  2. Stabilization of coordinated motion for underwater vehicles

    Institute of Scientific and Technical Information of China (English)

    Fan Wu; Zhi-Yong Geng

    2011-01-01

    This paper presents a coordinating and stabilizing control law for a group of underwater vehicles with unstable dynamics. The coordinating law is derived from a potential that only depends on the relative configuration of the underwater vehicles. Being coordinated, the group behaves like one mechanical system with symmetry, and we focus on stabilizing a family of coordinated motions, called relative equilibria. The stabilizing law is derived using energy shaping to stabilize the relative equilibria which involve each vehicle translating along its longest (unstable) axis without spinning,while maintaining a relative configuration within the group.The proposed control law is physically motivated and avoids the linearization or cancellation of nonlinearities.

  3. Early literacy

    DEFF Research Database (Denmark)

    Jensen, Anders Skriver

    2012-01-01

    This paper discusses findings from the Danish contribution to the EASE project, a European research project running from 2008 to 2010 on early literacy in relation to the transition from childcare to school. It explores a holistic, inclusive approach to early literacy that resists a narrow...... and schools. The paper also draws on Gee’s (2001, 2003, 2004, 2008) sociocultural approach to literacy, and Honneth’s (2003, 2006) concept of recognition. Emphasizing participation and recognition as key elements, it claims that stakeholders in early liter- acy must pay attention to how diverse early literacy...... opportunities empower children, especially when these opportunities are employed in a project-based learning environ- ment in which each child is able to contribute to the shared literacy events....

  4. New form of geodetic coordinate system taking two length quantity as coordinate parameters

    Institute of Scientific and Technical Information of China (English)

    Yimin SHI; Ziyang ZHU; Yeming FAN

    2009-01-01

    A new form of geodetic coordinate system based on geodesic coordinates instead of geodetic long-itude and latitude was proposed. The vertical and horizontal geodesic coordinates measured with length were defined as coordinate parameters, but the two families of coordinate curves were still meridians and parallel circles. The first fundamental form on the ellipsoidal surface and its three coefficients were deduced by the geodesic coordinate. The formula for the latitudinal scale factor of length for geodetic parallel lines was derived, by which the obtained result conformed to that standard value calculated from geodetic latitude, and it is applicable in the range of 400 km from north to south. Therefore, it lays the foundation for establishing the differential equation and differential relationship based on this type of coordinate parameters; and consequently, it is convenient and accurate enough to operate on the ellipsoidal surface in this new form of geodetic coordinate system.

  5. Coordinate systems and map projections

    CERN Document Server

    Maling, DH

    1992-01-01

    A revised and expanded new edition of the definitive English work on map projections. The revisions take into account the huge advances in geometrical geodesy which have occurred since the early years of satellite geodesy. The detailed configuration of the geoid resulting from the GEOS and SEASAT altimetry measurements are now taken into consideration. Additionally, the chapter on computation of map projections is updated bearing in mind the availability of pocket calculators and microcomputers. Analytical derivation of some map projections including examples of pseudocylindrical and polyconic

  6. [The coordination of care in health centres].

    Science.gov (United States)

    Ribardière, Olivia

    2016-06-01

    Health centres are structurally designed to facilitate the coordination of care. However, evolutions in society have resulted in forms of consumption of health care which are not necessarily compatible with efficient care coordination. On a local level, teams are nevertheless organising and structuring themselves to offer the right form of care, to the right patient and at the right time.

  7. 77 FR 260 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2012-01-04

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of call for nominations. SUMMARY: The Forest Resource Coordinating Committee (FRCC) is filling eight vacant positions. Candidates who wish to be considered for membership on the Forest...

  8. 42 CFR 38.1 - Purpose; coordination.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Purpose; coordination. 38.1 Section 38.1 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICAL CARE AND EXAMINATIONS DISASTER ASSISTANCE FOR CRISIS COUNSELING AND TRAINING § 38.1 Purpose; coordination. (a) Purpose. This...

  9. Politics of coordination in environmental health

    DEFF Research Database (Denmark)

    Holm, Jesper; Kjærgård, Bente; Jelsøe, Erling

    2015-01-01

    on environmental policy integration, for studying the efforts and paradoxes in sector co-ordination, in order to reflect on the pro et cons of integrative approaches to environment and public health. We will give an overview of the various approaches to coordinative efforts from an international to a national...

  10. Development of Coordination in Time Estimation

    Science.gov (United States)

    Kiefer, Adam W.; Wallot, Sebastian; Gresham, Lori J.; Kloos, Heidi; Riley, Michael A.; Shockley, Kevin; Van Orden, Guy

    2014-01-01

    How to best characterize cognitive development? The claim put forward in this article is that development is the improvement of a kind of coordination among a variety of factors. To determine the development of coordination in a cognitive task, children between 4 and 12 years of age and adults participated in a time estimation task: They had to…

  11. A coordination language for mobile components

    NARCIS (Netherlands)

    Arbab, F.; Bonsangue, M.M.; Boer, F.S. de

    1999-01-01

    Abstract In this paper we present the sigmapi coordination language, a core language for specifying dynamic networks of components. The language is inspired by the Manifold coordination language and by the pi-calculus. The main concepts of the language are components, classes, objects

  12. Motor Coordination and Intelligence Level in Adolescents

    Science.gov (United States)

    Planinsec, Jurij; Pisot, Rado

    2006-01-01

    This study investigated the relationship between motor coordination and intelligence level in adolescents. The sample was comprised of 550 adolescents from Slovenia, aged 13.1 years (SD = 0.87), who attended elementary schools. For assessment of motor coordination a battery of eight tests were used. Assessment of intelligence was carried out with…

  13. Energy Materials Coordinating Committee (EMaCC)

    Energy Technology Data Exchange (ETDEWEB)

    1991-05-31

    This report summarizes EMaCC activities for fiscal year 1990 and describes the materials research programs of various offices and divisions within the department. The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further the effective use of materials expertise within the department. (JL)

  14. 28 CFR 42.412 - Coordination.

    Science.gov (United States)

    2010-07-01

    ... General Guidelines, 28 CFR 50.3, the Assistant Attorney General may issue such directives and take such... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Coordination. 42.412 Section 42.412... PROCEDURES Coordination of Enforcement of Non-discrimination in Federally Assisted Programs §...

  15. 33 CFR 273.18 - Clearinghouse coordination.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Clearinghouse coordination. 273.18 Section 273.18 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE AQUATIC PLANT CONTROL § 273.18 Clearinghouse coordination. Procedures prescribed...

  16. 36 CFR 72.48 - Federal coordination.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Federal coordination. 72.48... and Innovation § 72.48 Federal coordination. Applicants requesting UPARR assistance under one of the three grant categories shall investigate the possibilities of administrative and/or funding...

  17. 29 CFR 1405.6 - Program coordination.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Program coordination. 1405.6 Section 1405.6 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE PART-TIME EMPLOYMENT Part-time Employment Program § 1405.6 Program coordination. The Director of Personnel is designated the...

  18. 40 CFR 35.272 - Funding coordination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Funding coordination. 35.272 Section 35.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE....272 Funding coordination. Recipients must use the lead-based paint program funding in a way...

  19. 42 CFR 2a.3 - Application; coordination.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Application; coordination. 2a.3 Section 2a.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS PROTECTION OF IDENTITY-RESEARCH SUBJECTS § 2a.3 Application; coordination. (a) Any person engaged in (or who intends...

  20. 44 CFR 60.26 - Local coordination.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Local coordination. 60.26 Section 60.26 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Flood-Related Erosion-Prone Areas § 60.26 Local coordination. (a) Local flood plain, mudslide...

  1. 47 CFR 78.36 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... in 47 CFR 101.105(a), (b), and (c) and the following frequency usage coordination procedures will... fixed satellite service, applicants must also comply with the requirements of 47 CFR 101.21(f). In... 47 Telecommunication 4 2010-10-01 2010-10-01 false Frequency coordination. 78.36 Section...

  2. 36 CFR 222.33 - Management coordination.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Management coordination. 222.33 Section 222.33 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE RANGE MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.33 Management coordination. All...

  3. 23 CFR 810.8 - Coordination.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Coordination. 810.8 Section 810.8 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS General § 810.8 Coordination. The Federal Highway Administrator and the Urban...

  4. 7 CFR 624.5 - Coordination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Coordination. 624.5 Section 624.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES EMERGENCY WATERSHED PROTECTION § 624.5 Coordination. (a) If the President...

  5. 40 CFR 35.691 - Funding coordination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Funding coordination. 35.691 Section 35.691 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE...(g)) § 35.691 Funding coordination. Recipients must use the Lead-Based Paint program funding in a...

  6. 20 CFR 631.83 - Coordination.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Coordination. 631.83 Section 631.83 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROGRAMS UNDER TITLE III OF THE JOB TRAINING PARTNERSHIP ACT Disaster Relief Employment Assistance § 631.83 Coordination. Funds made...

  7. 47 CFR 95.1111 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequency coordination. 95.1111 Section 95.1111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Wireless Medical Telemetry Service (WMTS) General Provisions § 95.1111 Frequency coordination....

  8. 47 CFR 80.513 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequency coordination. 80.513 Section 80.513 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Private Coast Stations and Marine Utility Stations § 80.513 Frequency coordination....

  9. Distributed Coordination of Household Electricity Consumption

    DEFF Research Database (Denmark)

    Juelsgaard, Morten; Teixeira, Andre; Johansson, Mikael

    2014-01-01

    This work presents a distributed framework for coordination of flexible electricity consumption for a number of households in the distribution grid. We conduct coordination with the purpose of minimizing a trade-off between individual concerns about discomfort and electricity cost, on the one hand...

  10. Advanced Coordinating Control System for Power Plant

    Institute of Scientific and Technical Information of China (English)

    WU Peng; WEI Shuangying

    2006-01-01

    The coordinating control system is popular used in power plant. This paper describes the advanced coordinating control by control methods and optimal operation, introduces their principals and features by using the examples of power plant operation. It is wealthy for automation application in optimal power plant operation.

  11. Guidelines for the Practice of Parenting Coordination

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Parenting coordination is a nonadversarial dispute resolution process that is court ordered or agreed on by divorced and separated parents who have an ongoing pattern of high conflict and/or litigation about their children. These guidelines are designed to address the developing area of practice known as parenting coordination. In response to the…

  12. Unpacking Coordination Benefits in Supply Networks

    DEFF Research Database (Denmark)

    Petrick, Irene J.; Maitland, Carleen; Pogrebnyakov, Nicolai

    2016-01-01

    This paper examines how coordination among firms in supply networks generates benefits in the short and long terms for firms. It focuses on information technology (IT) and process improvement coordination. Analysis was performed on quantitative and qualitative data from a sample of SMEs in plastics...

  13. You're a "What"? Recycling Coordinator

    Science.gov (United States)

    Torpey, Elka Maria

    2011-01-01

    Recycling coordinators supervise curbside and dropoff recycling programs for municipal governments or private firms. Today, recycling is mandatory in many communities. And advancements in collection and processing methods have helped to increase the quantity of materials for which the recycling coordinator is responsible. In some communities,…

  14. A Comparison of Serve Speed and Motor Coordination between Elite and Club Level Tennis Players

    Directory of Open Access Journals (Sweden)

    Söğüt Mustafa

    2017-01-01

    Full Text Available The purpose of this study was to compare the serve speed and motor coordination of elite and club level junior tennis players aged 11-14 years. Participants (n=35 were assigned to one of the two groups according to their experience, weekly training volume and competition level. Serve speed was assessed with a sports radar gun. Motor coordination was evaluated by means of the Körperkoordinationstest für Kinder. The main results revealed that serve speed and motor coordination performance levels of the elite group were significantly higher than those of the club group. This study emphasized the importance of early participation and training intensity, which can play an important role in enhancement of serve speed and motor coordination.

  15. A Comparison of Serve Speed and Motor Coordination between Elite and Club Level Tennis Players

    Science.gov (United States)

    2017-01-01

    Abstract The purpose of this study was to compare the serve speed and motor coordination of elite and club level junior tennis players aged 11-14 years. Participants (n=35) were assigned to one of the two groups according to their experience, weekly training volume and competition level. Serve speed was assessed with a sports radar gun. Motor coordination was evaluated by means of the Körperkoordinationstest für Kinder. The main results revealed that serve speed and motor coordination performance levels of the elite group were significantly higher than those of the club group. This study emphasized the importance of early participation and training intensity, which can play an important role in enhancement of serve speed and motor coordination. PMID:28210349

  16. Rhythmic coordination dynamics in children with and without a developmental coordination disorder

    NARCIS (Netherlands)

    Volman, Michiel Joannes Maria

    1997-01-01

    The aim of the present thesis is to examine the intrinsic dynamics of rhythmic coordinated actions in children with and without DCD by testing the stability of these patterns. Two basically different coordination systems are examined, namely, rhythmic interlimb coordination and rhythmic perception-a

  17. Collaborative Supply Chain Planning and Coordination

    DEFF Research Database (Denmark)

    Wong, Chee Yew

    This thesis contains main results from an industrial PhD research in the areas of supply chain strategy, planning, and coordination. It applies the concepts of responsiveness and coordination to reduce mismatch of supply and demand, especially for a volatile and seasonal supply chain. It involves...... a series of case studies on the process of planning coordination between a toy manufacturer (LEGO Company) and its major European customers (toy retailers). The thesis presents a plurality of six selected research papers and a main report. These research papers provide case analyses while the main report...... and coordination, the thesis concludes a concept called Coordinated Responsiveness. It finally discusses the main contributions and implications of this research, the reflections on the research process and some future research....

  18. Learning and coordinating in a multilayer network

    CERN Document Server

    Lugo, Haydee

    2014-01-01

    We introduce a two layer network model for social coordination incorporating two relevant ingredients: a) different networks of interaction to learn and to obtain a payoff , and b) decision making processes based both on social and strategic motivations. Two populations of agents are distributed in two layers with intralayer learning processes and playing interlayer a coordination game. We find that the skepticism about the wisdom of crowd and the local connectivity are the driving forces to accomplish full coordination of the two populations, while polarized coordinated layers are only possible for all-to-all interactions. Local interactions also allow for full coordination in the socially efficient Pareto-dominant strategy in spite of being the riskier one.

  19. Relational Coordination in Danish General Practice

    DEFF Research Database (Denmark)

    Lundstrøm, Sanne Lykke

    and relationship networks through which work is coordinated across functional and organisational boundaries. Previous studies have shown that relational coordination is positively associated with delivery of care for patients with chronic illness. Organisational social capital is used when analysing...... the psychosocial work environment in organisations, and is seen as a powerful resources for improving organisational performance. Relational coordination and organisational social capital may oer new insight and opportunities for general practice to learn. General practice provides cost-efficient, first....... The dissertation present the research study and a collection of three research papers prepared during the period from May 2010 to June 2014. Relational coordination and organisational social capital are measures of novel aspects of an organisation's performance. Relational coordination analyse the communication...

  20. Scalable Social Coordination using Enmeshed Queries

    CERN Document Server

    Chen, Jianjun; Varghese, George

    2012-01-01

    Social coordination allows users to move beyond awareness of their friends to efficiently coordinating physical activities with others. While specific forms of social coordination can be seen in tools such as Evite, Meetup and Groupon, we introduce a more general model using what we call {\\em enmeshed queries}. An enmeshed query allows users to declaratively specify an intent to coordinate by specifying social attributes such as the desired group size and who/what/when, and the database returns matching queries. Enmeshed queries are continuous, but new queries (and not data) answer older queries; the variable group size also makes enmeshed queries different from entangled queries, publish-subscribe systems, and dating services. We show that even offline group coordination using enmeshed queries is NP-hard. We then introduce efficient heuristics that use selective indices such as location and time to reduce the space of possible matches; we also add refinements such as delayed evaluation and using the relative...

  1. Knowledge coordination in distributed software management

    DEFF Research Database (Denmark)

    Persson, John Stouby; Mathiassen, Lars

    2012-01-01

    Software organizations are increasingly relying on cross-organizational and cross-border collaboration, requiring effective coordination of distributed knowledge. However, such coordination is challenging due to spatial separation, diverging communities-of-practice, and unevenly distributed...... resources. We have therefore studied virtual meetings among the managers of a cross-organizational and cross-border joint venture who was highly dedicated to multimodal communication. Since coordination is most clearly noticeable when it is lacking, we investigated knowledge coordination by analyzing...... communication breakdowns on recordings of their combined teleconferencing and real-time collaborative modeling. As a result, we offer theoretical propositions that explain how distributed software managers can deal with communication breakdowns and effectively coordinate knowledge through multimodal virtual...

  2. Coordinate metrology accuracy of systems and measurements

    CERN Document Server

    Sładek, Jerzy A

    2016-01-01

    This book focuses on effective methods for assessing the accuracy of both coordinate measuring systems and coordinate measurements. It mainly reports on original research work conducted by Sladek’s team at Cracow University of Technology’s Laboratory of Coordinate Metrology. The book describes the implementation of different methods, including artificial neural networks, the Matrix Method, the Monte Carlo method and the virtual CMM (Coordinate Measuring Machine), and demonstrates how these methods can be effectively used in practice to gauge the accuracy of coordinate measurements. Moreover, the book includes an introduction to the theory of measurement uncertainty and to key techniques for assessing measurement accuracy. All methods and tools are presented in detail, using suitable mathematical formulations and illustrated with numerous examples. The book fills an important gap in the literature, providing readers with an advanced text on a topic that has been rapidly developing in recent years. The book...

  3. The Development of Coordinated Communication in Infants at Heightened Risk for Autism Spectrum Disorder

    Science.gov (United States)

    Parladé, Meaghan V.; Iverson, Jana M.

    2015-01-01

    This study evaluated the extent to which developmental change in coordination of social communication in early infancy differentiates children eventually diagnosed with ASD from those not likely to develop the disorder. A prospective longitudinal design was used to compare nine infants at heightened risk for ASD (HR) later diagnosed with ASD, to…

  4. Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation

    OpenAIRE

    Haremaki, Tomomi; Fraser, Stuart T.; Kuo, Yien-Ming; Baron, Margaret H.; Weinstein, Daniel C.

    2007-01-01

    Embryogenesis involves two distinct processes. On the one hand, cells must specialize, acquiring fates appropriate to their positions (differentiation); on the other hand, they must physically construct the embryo through coordinated mechanical activity (morphogenesis). In early vertebrate development, fibroblast growth factor (FGF) regulates multiple embryonic events, including germ layer differentiation and morphogenesis; the cellular components that direct FGF signaling to evoke these diff...

  5. Farmers, Vertical Coordination, and the Restructuring of Dairy Supply Chains in Central and Eastern Europe

    NARCIS (Netherlands)

    Dries, L.K.E.; Germenji, E.; Noev, N.; Swinnen, J.

    2009-01-01

    The combination of transition and globalization since the early 1990s has caused dramatic changes in the dairy chains in Central and Eastern Europe. This paper uses survey evidence from several Central and East European countries to document the growth of vertical coordination in the dairy chain, it

  6. Limes and Lemons: Teaching and Learning in Preschool as the Coordination of Perspectives and Sensory Modalities

    Science.gov (United States)

    Kultti, Anne; Pramling, Niklas

    2015-01-01

    This article proposes a conceptualization of teaching and learning in early childhood education, as the coordination of perspectives held by children and teachers through engaging different sensory modalities in the learning process. It takes a sociocultural theoretical perspective. An empirical example from a routine mealtime situation is…

  7. Spanish translation Questionnaire of the Developmental Coordination Disorder

    Directory of Open Access Journals (Sweden)

    Salamanca LM

    2012-05-01

    Full Text Available The developmental coordination disorder can be recognized by motor difficulties that affect the performance in daily and school activities; therefore, it is necessary to get its early diagnosis in order to initiate early intervention. A tool for diagnosis is the Developmental coordination disorder questionnaire’07, DCDQ’07. Objective: the translation and cultural adaptation of the DCDQ’07 into Spanish. Materials and methods: three independent translators translated the questionnaire into Spanish. Its items were classified according to their equivalent or non-equivalent problems in some words, and also according to their experiential, semantic, conceptual or idioms equivalence. Results: 8 items out of 15 questionnaire items were classified as equivalent 8, 6 of them presented problems in a few words and only one was classified as non-equivalent, 10 items correspond to experiential equivalence translation, 4 items were classified as semantic equivalent and only one got two equivalents. The author agreed the Spanish version. Also, the parent´s opinions about the questionnaire were positive. Conclusions: most of the items of the questionnaire did not have translation difficulties. It allowed its translation and cultural adaptation into Spanish as well as its validation continuity and reliability process

  8. Station Coordinates Combination Status and Contribution to ITRF2005

    Science.gov (United States)

    Ferland, R.

    2007-12-01

    Under the auspices of the International GNSS Service (IGS), the Reference Frame Working Group combines at Natural Resources Canada (NRCan) an accurate and consistent set of station coordinates, velocities and Earth Rotation Parameters (ERP) that are updated weekly. The consistency of these parameters is ensured by simultaneously combining them using their full variance-covariance information. The IGS Analysis Centers (ACs) (cod, emr, esa, gfz, jpl, mit, ngs, sio) provide the solutions used in the IGS weekly combination. The Global Network Associates Analysis Centers (GNAAC) (mit, ncl) also generate weekly combined solutions that include consistent station coordinates and ERPs. Those GNAAC solutions are used for comparisons and quality control of the IGS weekly solution. In recent weeks each AC has been contributing between about 50 and 250 station coordinates estimates. The combined product currently approaches 300 stations. Of those, between 40 and 110 are used for the current IGS reference frame realization of the ITRF2005 in each AC solution. The quality of the AC station coordinates solutions has improved significantly since they have started contributing in early 1996. This is due to the densification of the network of stations along with gradual improvements in station hardware and processing software. For recent solutions, the estimated noise (std. dev.) level between the AC weekly solutions and the different combined solutions varies between 1-3mm horizontally and 2-10mm vertically. More details about the statistics, their evolution and differences between the ACs will be presented. IGS weekly station coordinates and ERP combined products have also been contributed to the ITRF2005. Those weekly solutions were all recombined from the original AC contributions, going back to the beginning of 1996. The recombined solutions were edited for known problems (e.g. incorrect antenna heights and outliers). Several stations with short time span were also removed. A

  9. Optimized coordinates for anharmonic vibrational structure theories.

    Science.gov (United States)

    Yagi, Kiyoshi; Keçeli, Murat; Hirata, So

    2012-11-28

    A procedure to determine optimal vibrational coordinates is developed on the basis of an earlier idea of Thompson and Truhlar [J. Chem. Phys. 77, 3031 (1982)]. For a given molecule, these coordinates are defined as the unitary transform of the normal coordinates that minimizes the energy of the vibrational self-consistent-field (VSCF) method for the ground state. They are justified by the fact that VSCF in these coordinates becomes exact in two limiting cases: harmonic oscillators, where the optimized coordinates are normal, and noninteracting anharmonic oscillators, in which the optimized coordinates are localized on individual oscillators. A robust and general optimization algorithm is developed, which decomposes the transformation matrix into a product of Jacobi matrices, determines the rotation angle of each Jacobi matrix that minimizes the energy, and iterates the process until a minimum in the whole high dimension is reached. It is shown that the optimized coordinates are neither entirely localized nor entirely delocalized (or normal) in any of the molecules (the water, water dimer, and ethylene molecules) examined (apart from the aforementioned limiting cases). Rather, high-frequency stretching modes tend to be localized, whereas low-frequency skeletal vibrations remain normal. On the basis of these coordinates, we introduce two new vibrational structure methods: optimized-coordinate VSCF (oc-VSCF) and optimized-coordinate vibrational configuration interaction (oc-VCI). For the modes that become localized, oc-VSCF is found to outperform VSCF, whereas, for both classes of modes, oc-VCI exhibits much more rapid convergence than VCI with respect to the rank of excitations. We propose a rational configuration selection for oc-VCI when the optimized coordinates are localized. The use of the optimized coordinates in VCI with this configuration selection scheme reduces the mean absolute errors in the frequencies of the fundamentals and the first overtones

  10. Transforming geocentric cartesian coordinates to geodetic coordinates by using differential search algorithm

    Science.gov (United States)

    Civicioglu, Pinar

    2012-09-01

    In order to solve numerous practical navigational, geodetic and astro-geodetic problems, it is necessary to transform geocentric cartesian coordinates into geodetic coordinates or vice versa. It is very easy to solve the problem of transforming geodetic coordinates into geocentric cartesian coordinates. On the other hand, it is rather difficult to solve the problem of transforming geocentric cartesian coordinates into geodetic coordinates as it is very hard to define a mathematical relationship between the geodetic latitude (φ) and the geocentric cartesian coordinates (X, Y, Z). In this paper, a new algorithm, the Differential Search Algorithm (DS), is presented to solve the problem of transforming the geocentric cartesian coordinates into geodetic coordinates and its performance is compared with the performances of the classical methods (i.e., Borkowski, 1989; Bowring, 1976; Fukushima, 2006; Heikkinen, 1982; Jones, 2002; Zhang, 2005; Borkowski, 1987; Shu, 2010 and Lin, 1995) and Computational-Intelligence algorithms (i.e., ABC, JDE, JADE, SADE, EPSDE, GSA, PSO2011, and CMA-ES). The statistical tests realized for the comparison of performances indicate that the problem-solving success of DS algorithm in transforming the geocentric cartesian coordinates into geodetic coordinates is higher than those of all classical methods and Computational-Intelligence algorithms used in this paper.

  11. FGF signalling: diverse roles during early vertebrate embryogenesis.

    Science.gov (United States)

    Dorey, Karel; Amaya, Enrique

    2010-11-01

    Fibroblast growth factor (FGF) signalling has been implicated during several phases of early embryogenesis, including the patterning of the embryonic axes, the induction and/or maintenance of several cell lineages and the coordination of morphogenetic movements. Here, we summarise our current understanding of the regulation and roles of FGF signalling during early vertebrate development.

  12. Hybrid Optimized and Localized Vibrational Coordinates.

    Science.gov (United States)

    Klinting, Emil Lund; König, Carolin; Christiansen, Ove

    2015-11-01

    We present a new type of vibrational coordinates denoted hybrid optimized and localized coordinates (HOLCs) aiming at a good set of rectilinear vibrational coordinates supporting fast convergence in vibrational stucture calculations. The HOLCs are obtained as a compromise between the recently promoted optimized coordinates (OCs) and localized coordinates (LCs). The three sets of coordinates are generally different from each other and differ from standard normal coordinates (NCs) as well. In determining the HOLCs, we optimize the vibrational self-consistent field (VSCF) energy with respect to orthogonal transformation of the coordinates, which is similar to determining OCs but for HOLCs we additionally introduce a penalty for delocalization, by using a measure of localization similar to that employed in determining LCs. The same theory and implementation covers OCs, LCs, and HOLCs. It is shown that varying one penalty parameter allows for connecting OCs and LCs. The HOLCs are compared to NCs, OCs, and LCs in their nature and performance as basis for vibrational coupled cluster (VCC) response calculations of vibrational anharmonic energies for a small set of simple systems comprising water, formaldehyde, and ethylene. It is found that surprisingly good results can be obtained with HOLCs by using potential energy surfaces as simple as quadratic Taylor expansions. Quite similar coordinates are found for the already established OCs but obtaining these OCs requires much more elaborate and expensive potential energy surfaces and localization is generally not guaranteed. The ability to compute HOLCs for somewhat larger systems is demonstrated for coumarin and the alanine quadramer. The good agreement between HOLCs and OCs, together with the much easier applicability of HOLCs for larger systems, suggests that HOLCs may be a pragmatically very interesting option for anharmonic calculations on medium to large molecular systems.

  13. Coordination Logic for Repulsive Resolution Maneuvers

    Science.gov (United States)

    Narkawicz, Anthony J.; Munoz, Cesar A.; Dutle, Aaron M.

    2016-01-01

    This paper presents an algorithm for determining the direction an aircraft should maneuver in the event of a potential conflict with another aircraft. The algorithm is implicitly coordinated, meaning that with perfectly reliable computations and information, it will in- dependently provide directional information that is guaranteed to be coordinated without any additional information exchange or direct communication. The logic is inspired by the logic of TCAS II, the airborne system designed to reduce the risk of mid-air collisions between aircraft. TCAS II provides pilots with only vertical resolution advice, while the proposed algorithm, using a similar logic, provides implicitly coordinated vertical and horizontal directional advice.

  14. A coordinate description of partonic processes

    CERN Document Server

    Erdogan, Ozan

    2016-01-01

    We review a perturbative description of amplitudes in coordinate space, aiming at an intuitive perspective on the roles of "long" and "short" distances. We begin with coordinate-space leading regions for fixed-angle scattering amplitudes, and develop approximations and factorizations in analogy to similar procedures in momentum space. There are also applications to products of Wilson lines, including the familiar cusp amplitude. We briefly discuss cross sections from the coordinate viewpoint, and the mechanism by which infrared singularities cancel in inclusive cross sections.

  15. The yolk syncytial layer in early zebrafish development.

    Science.gov (United States)

    Carvalho, Lara; Heisenberg, Carl-Philipp

    2010-10-01

    The yolk syncytial layer (YSL) plays crucial roles in early zebrafish development. The YSL is a transient extra-embryonic syncytial tissue that forms during early cleavage stages and persists until larval stages. During gastrulation, the YSL undergoes highly dynamic movements, which are tightly coordinated with the movements of the overlying germ layer progenitor cells, and has critical functions in cell fate specification and morphogenesis of the early germ layers. Movement coordination between the YSL and blastoderm cells is dependent on contact between these tissues, and is probably required for the patterning and morphogenetic function of the YSL. In this review, we will discuss recent advances in elucidating the molecular and cellular mechanisms underlying the YSL morphogenesis and movement coordination between the YSL and blastoderm during early development.

  16. Modeling, Control and Coordination of Helicopter Systems

    CERN Document Server

    Ren, Beibei; Chen, Chang; Fua, Cheng-Heng; Lee, Tong Heng

    2012-01-01

    Modeling, Control and Coordination of Helicopter Systems provides a comprehensive treatment of helicopter systems, ranging from related nonlinear flight dynamic modeling and stability analysis to advanced control design for single helicopter systems, and also covers issues related to the coordination and formation control of multiple helicopter systems to achieve high performance tasks. Ensuring stability in helicopter flight is a challenging problem for nonlinear control design and development. This book is a valuable reference on modeling, control and coordination of helicopter systems,providing readers with practical solutions for the problems that still plague helicopter system design and implementation. Readers will gain a complete picture of helicopters at the systems level, as well as a better understanding of the technical intricacies involved. This book also: Presents a complete picture of modeling, control and coordination for helicopter systems Provides a modeling platform for a general class of ro...

  17. Relativistic Positioning Systems: The Emission Coordinates

    CERN Document Server

    Coll, B; Coll, Bartolom\\'{e}; Pozo, Jos\\'{e} Mar\\'{I}a

    2006-01-01

    This paper introduces some general properties of the gravitational metric and the natural basis of vectors and covectors in 4-dimensional emission coordinates. Emission coordinates are a class of space-time coordinates defined and generated by 4 emitters (satellites) broadcasting their proper time by means of electromagnetic signals. They are a constitutive ingredient of the simplest conceivable relativistic positioning systems. Their study is aimed to develop a theory of these positioning systems, based on the framework and concepts of general relativity, as opposed to introducing `relativistic effects' in a classical framework. In particular, we characterize the causal character of the coordinate vectors, covectors and 2-planes, which are of an unusual type. We obtain the inequality conditions for the contravariant metric to be Lorentzian, and the non-trivial and unexpected identities satisfied by the angles formed by each pair of natural vectors. We also prove that the metric can be naturally split in such...

  18. Dynnikov coordinates on virtual braid groups

    CERN Document Server

    Bardakov, Valerij G; Wiest, Bert

    2011-01-01

    We define Dynnikov coordinates on virtual braid groups. We prove that they are faithful invariants of virtual 2-braids, and present evidence that they are also very powerful invariants for general virtual braids.

  19. Coordinating knowledge transfer within manufacturing networks

    DEFF Research Database (Denmark)

    Yang, Cheng; Johansen, John; Boer, Harry

    2008-01-01

    Along with increasing globalization, the management of international manufacturing networks is becoming increasingly important for industrial companies. This paper mainly focuses on the coordination of knowledge transfer within manufacturing networks. In this context, we propose the time-place ma...

  20. Coordination Approaches for Complex Software Systems

    NARCIS (Netherlands)

    Bosse, T.; Hoogendoorn, M.; Treur, J.

    2006-01-01

    This document presents the results of a collaboration between the Vrije Universiteit Amsterdam, Department of Artificial Intelligence and Force Vision to investigate coordination approaches for complex software systems. The project was funded by Force Vision.

  1. 47 CFR 15.525 - Coordination requirements.

    Science.gov (United States)

    2010-10-01

    ... the UWB device. If the imaging device is intended to be used for mobile applications, the geographical... coordination of routine UWB operations shall not take longer than 15 business days from the receipt of...

  2. HYbrid Coordinate Ocean Model (HYCOM): Global

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Global HYbrid Coordinate Ocean Model (HYCOM) and U.S. Navy Coupled Ocean Data Assimilation (NCODA) 3-day, daily forecast at approximately 9-km (1/12-degree)...

  3. Anatomic Breast Coordinate System for Mammogram Analysis

    DEFF Research Database (Denmark)

    Karemore, Gopal Raghunath; Brandt, S; Karssemeijer, N;

    2011-01-01

    inside the breast. Most of the risk assessment and CAD modules use a breast region in a image centered Cartesian x,y coordinate system. Nevertheless, anatomical structure follows curve-linear trajectories. We examined an anatomical breast coordinate system that preserves the anatomical correspondence...... between the mammograms and allows extracting not only the aligned position but also the orientation aligned with the anatomy of the breast tissue structure. Materials and Methods The coordinate system used the nipple location as the point A and the border of the pectoral muscle as a line BC. The skin air...... was represented by geodesic distance (s) from nipple and parametric angle (¿) as shown in figure 1. The scoring technique called MTR (mammographic texture resemblance marker) used this breast coordinate system to extract Gaussian derivative features. The features extracted using the (x,y) and the curve...

  4. Superfield extended BRST quantization in general coordinates

    CERN Document Server

    Geyer, B; Lavrov, P M; Moshin, P Y

    2004-01-01

    We propose a superfield formalism of Lagrangian BRST-antiBRST quantization of arbitrary gauge theories in general coordinates with the base manifold of fields and antifields desribed in terms of both bosonic and fermionic variables.

  5. Selective Placement Program Coordinator (SPPC) Directory

    Data.gov (United States)

    Office of Personnel Management — List of the Selective Placement Program Coordinators (SPPC) in Federal agencies, updated as needed. Users can filter the list by choosing a state and/or agency name.

  6. Coordinate transformation approach to social interactions

    Directory of Open Access Journals (Sweden)

    Steve W C Chang

    2013-08-01

    Full Text Available A coordinate transformation framework for understanding how neurons compute sensorimotor behaviors has generated significant advances towards our understanding of basic brain function. This influential scaffold focuses on neuronal encoding of spatial information represented in different coordinate systems (e.g., eye-centered, hand-centered and how multiple brain regions partake in transforming these signals in order to ultimately generate a motor output. A powerful analogy can be drawn from the coordinate transformation framework to better elucidate how the nervous system computes cognitive variables for social behavior. Of particular relevance is how the brain represents information with respect to oneself and other individuals, such as in reward outcome assignment during social exchanges, in order to influence social decisions. In this article, I outline how the coordinate transformation framework can help guide our understanding of neural computations resulting in social interactions. Implications for numerous psychiatric disorders with impaired representations of self and others are also discussed.

  7. Language as a coordination tool evolves slowly

    Science.gov (United States)

    2016-01-01

    Social living ultimately depends on coordination between group members, and communication is necessary to make this possible. We suggest that this might have been the key selection pressure acting on the evolution of language in humans and use a behavioural coordination model to explore the impact of communication efficiency on social group coordination. We show that when language production is expensive but there is an individual benefit to the efficiency with which individuals coordinate their behaviour, the evolution of efficient communication is selected for. Contrary to some views of language evolution, the speed of evolution is necessarily slow because there is no advantage in some individuals evolving communication abilities that much exceed those of the community at large. However, once a threshold competence has been achieved, evolution of higher order language skills may indeed be precipitate. PMID:28083091

  8. The Lanthanide Contraction beyond Coordination Chemistry.

    Science.gov (United States)

    Ferru, Geoffroy; Reinhart, Benjamin; Bera, Mrinal K; Olvera de la Cruz, Monica; Qiao, Baofu; Ellis, Ross J

    2016-05-10

    The lanthanide contraction is conceptualized traditionally through coordination chemistry. Here we break this mold in a structural study of lanthanide ions dissolved in an amphiphilic liquid. The lanthanide contraction perturbs the weak interactions between molecular aggregates that drive mesoscale assembly and emergent behavior. The weak interactions correlate with lanthanide ion transport properties, suggesting new strategies for rare-earth separation that exploit forces outside of the coordination sphere.

  9. Coordinating Learning Agents for Active Information Collection

    Science.gov (United States)

    2011-06-30

    ranging from robocup soccer [26, 27], to rover coordination [19], to trading agents [25, 43], to air traffic management [32]. What makes this problem...Bazzan, A. and Ossowski, S. (eds.), Applications of Agent Technology in Traffic and Transportation ( Springer , 2005). [19] Mataric, M. J., Coordination...of Complex Systems ( Springer , 2004). September 16, 2009 16:40 WSPC/169-ACS 00230 472 K. Tumer and N. Khani [24] Pynadath, D. and Tambe, M., The

  10. Zinc coordination spheres in protein structures.

    Science.gov (United States)

    Laitaoja, Mikko; Valjakka, Jarkko; Jänis, Janne

    2013-10-07

    Zinc metalloproteins are one of the most abundant and structurally diverse proteins in nature. In these proteins, the Zn(II) ion possesses a multifunctional role as it stabilizes the fold of small zinc fingers, catalyzes essential reactions in enzymes of all six classes, or assists in the formation of biological oligomers. Previously, a number of database surveys have been conducted on zinc proteins to gain broader insights into their rich coordination chemistry. However, many of these surveys suffer from severe flaws and misinterpretations or are otherwise limited. To provide a more comprehensive, up-to-date picture on zinc coordination environments in proteins, zinc containing protein structures deposited in the Protein Data Bank (PDB) were analyzed in detail. A statistical analysis in terms of zinc coordinating amino acids, metal-to-ligand bond lengths, coordination number, and structural classification was performed, revealing coordination spheres from classical tetrahedral cysteine/histidine binding sites to more complex binuclear sites with carboxylated lysine residues. According to the results, coordination spheres of hundreds of crystal structures in the PDB could be misinterpreted due to symmetry-related molecules or missing electron densities for ligands. The analysis also revealed increasing average metal-to-ligand bond length as a function of crystallographic resolution, which should be taken into account when interrogating metal ion binding sites. Moreover, one-third of the zinc ions present in crystal structures are artifacts, merely aiding crystal formation and packing with no biological significance. Our analysis provides solid evidence that a minimal stable zinc coordination sphere is made up by four ligands and adopts a tetrahedral coordination geometry.

  11. Trust and team coordination in critical situations

    Directory of Open Access Journals (Sweden)

    Adrian H. Pitariu

    2008-01-01

    Full Text Available In this paper I explore the process of team coordination. I propose a model by which team coordination emerges as a function of team mental models and team trust. Furthermore, I introduce a hierarchical approach to team mental models, and propose a framework that provides a better understanding of team processes and opens new avenues of research in the area of team cognition. I conclude with implications for future research and practice.

  12. On Double Interpolation in Polar Coordinates

    Directory of Open Access Journals (Sweden)

    Antoniu Nicula

    2009-10-01

    Full Text Available Interpolation is an important tool in numerical modeling of real-life systems. The Lagrange interpolation is frequently used, due to particular advantages in implementation. The bi-dimensional version may be implemented with Cartesian or with polar coordinate system. Choice of the coordinate system is important in order to obtain accurate results. The polar case has particular properties that can be exploited to minimize some of the common disadvantages of polynomial interpolation.

  13. Trunk coordination in dancers and nondancers.

    Science.gov (United States)

    Jarvis, Danielle N; Smith, Jo Armour; Kulig, Kornelia

    2014-08-01

    Variability, or how a task changes across trials, may reveal differences between athletes of differing skill levels. The purpose of this study was to examine trunk and lower extremity (LE) single joint kinematic variability and intersegmental coordination variability in dancers and nondancers during bipedal vertical dance jumps (sautés). Twenty healthy females, 10 with no formal dance training and 10 professional dancers, performed 20 consecutive sautés. Single joint kinematic variability was assessed using mean standard deviation of angular displacement, and intersegmental coordination variability was assessed using angular deviation of the coupling angle between segments. Within the context of the standard error of measure, there was no difference in single joint kinematic variability between dancers and nondancers. Intersegmental coordination variability in the trunk was higher than variability in LE couplings for both groups. Dancers had lower intersegmental coordination variability than nondancers for LE sagittal, frontal, and transverse plane couplings, and sagittal plane trunk couplings. Trunk adjustments may be important for successful performance, but lower intersegmental coordination variability in expert dancers indicates a higher level of control. Trunk coordination and postural control may be important factors to investigate in skilled athletes.

  14. Chemical Principles Revisited: Some Aspects of Coordination Chemistry.

    Science.gov (United States)

    Mickey, Charles D.

    1981-01-01

    Reviews characteristics of coordination chemistry, the study of coordination compounds, a major focal point for the inorganic chemist. Provides a brief history regarding the Wernerian System and background information in modern coordination theory. (CS)

  15. 78 FR 37781 - Forest Resource Coordinating Committee; Meeting

    Science.gov (United States)

    2013-06-24

    ... Forest Service Forest Resource Coordinating Committee; Meeting AGENCY: Forest Service, USDA. ACTION: Notice of meeting; Correction. SUMMARY: The Forest Service published a document in the Federal Register... FURTHER INFORMATION CONTACT: Maya Solomon, Forest Resource Coordinating Committee Program Coordinator,...

  16. 44 CFR 206.42 - Responsibilities of coordinating officers.

    Science.gov (United States)

    2010-10-01

    ... as necessary to coordinate and monitor assistance programs, disseminate information, accept applications, and counsel individuals, families and businesses concerning available assistance; (3) Coordinate... SCO coordinates State and local disaster assistance efforts with those of the Federal...

  17. Care Coordination Associated with Improved Timing of Newborn Primary Care Visits.

    Science.gov (United States)

    Goyal, Neera K; Hall, Eric S; Kahn, Robert S; Wexelblatt, Scott L; Greenberg, James M; Samaan, Zeina M; Brown, Courtney M

    2016-09-01

    Objective Despite practice recommendations that all newborns be examined within 3-5 days after discharge, many are not seen within this timeframe. Our objective was to determine the association between care coordination and timing of newborn follow-up. Methods This retrospective study evaluated 6251 newborns from eight maternity hospitals who scheduled a primary care appointment at one of two academic pediatric practices over 3.5 years. Two programs were sequentially implemented: (1) newborn discharge coordination, and (2) primary care intake coordination. Primary outcome was days between discharge and follow-up, dichotomized as ≤ or >5 days. Number of rescheduled appointments and loss to follow-up were also assessed. Adjusted relative risks (RR) and odds ratios (OR) were determined by piecewise generalized linear and logistic regression. Results Among 5943 newborns with a completed visit, 52.9 % were seen within 5 days of discharge (mean 6.7 days). After multivariable adjustment, the pre-exposure period (8 months) demonstrated a downward monthly trend in completing early follow-up (RR 0.93, p coordinator implementation and roughly 33 % after primary care coordinator implementation. The latter was also associated with a 13 % monthly decrease in odds of loss to follow-up (OR 0.87, p Care coordination increases adherence among low income families to recommended newborn follow-up after birth hospitalization.

  18. Expression of strain tensor in orthogonal curvilinear coordinates

    Directory of Open Access Journals (Sweden)

    Xuyan Liu

    2010-01-01

    Full Text Available Based on an analysis of connotation and extension of the concept of the orthogonal curvilinear coordinates, we have deduced a platform of strain tensor expression of Cartesian coordinates, which turns out to be a function of Lame coefficient and unit vector. By using transform matrix between Cartesian coordinates and orthogonal curvilinear coordinates, we have deduced a mathematical expression for correcting displacement vector differential in orthogonal curvilinear coordinates, and given a general expression of strain tensor in orthogonal curvilinear coordinates.

  19. Research and innovation in teacher’s training and the services’s coordinators for children in Italy

    Directory of Open Access Journals (Sweden)

    Cristina Stringher

    2012-04-01

    Full Text Available In this article we discuss about the training of teachers and coordinators in early childhood education and care (ECEC services in Italy. We are doing this through two parts: in the first one, after an introduction on the topic of ECEC quality, we give an account of present profiles of educators in baby centres (asili nido, educators in pre-schools and coordinators of 0-6 services; the second part presents two exemplary experiences of initial training of teachers and coordinators carried out in the Universities of Bologna and Roma-Tre. We proceed departing from critical issues emerging from the analysis of profiles.

  20. Analysis of Coordinated Motions of Humanoid Robot Fingers Using Interphalangeal Joint Coordination

    Directory of Open Access Journals (Sweden)

    Byoung-Ho Kim

    2014-04-01

    Full Text Available In this study, we analyse the coordinated motions of humanoid robot fingers using an interphalangeal joint coordination. For this purpose, four humanoid robot fingers with different sizes have been considered. A biomimetic interphalangeal joint coordination (IJC formulation based on the grasp configuration of human fingers has been presented for humanoid robot fingers. The usefulness of the specified IJC formulation for human-like finger motion has been verified through comparative demonstrations. As a result, a proper coordination of humanoid robot fingertips can be achieved by applying our IJC formulation. Also the IJC formulation can be used to design of humanoid robot fingers.

  1. Postural Coordination during Socio-motor Improvisation.

    Science.gov (United States)

    Gueugnon, Mathieu; Salesse, Robin N; Coste, Alexandre; Zhao, Zhong; Bardy, Benoît G; Marin, Ludovic

    2016-01-01

    Human interaction often relies on socio-motor improvisation. Creating unprepared movements during social interaction is not a random process but relies on rules of synchronization. These situations do not only involve people to be coordinated, but also require the adjustment of their posture in order to maintain balance and support movements. The present study investigated posture in such a context. More precisely, we first evaluated the impact of amplitude and complexity of arm movements on posture in solo situation. Then, we assessed the impact of interpersonal coordination on posture using the mirror game in which dyads performed improvised and synchronized movements (i.e., duo situation). Posture was measured through ankle-hip coordination in medio-lateral and antero-posterior directions (ML and AP respectively). Our results revealed the spontaneous emergence of in-phase pattern in ML direction and antiphase pattern in AP direction for solo and duo situations. These two patterns respectively refer to the simultaneous flexion/extension of the ankles and the hips in the same or opposite direction. It suggests different functional roles of postural coordination patterns in each direction, with in-phase supporting task performance in ML (dynamical stability) and antiphase supporting postural control in AP (mechanical stability). Although amplitude of movement did not influence posture, movement complexity disturbed postural stability in both directions. Conversely, interpersonal coordination promoted postural stability in ML but not in AP direction. These results are discussed in terms of the difference in coupling strength between ankle-hip coordination and interpersonal coordination.

  2. Transcriptional coordination of synaptogenesis and neurotransmitter signaling.

    Science.gov (United States)

    Kratsios, Paschalis; Pinan-Lucarré, Bérangère; Kerk, Sze Yen; Weinreb, Alexis; Bessereau, Jean-Louis; Hobert, Oliver

    2015-05-18

    During nervous system development, postmitotic neurons face the challenge of generating and structurally organizing specific synapses with appropriate synaptic partners. An important unexplored question is whether the process of synaptogenesis is coordinated with the adoption of specific signaling properties of a neuron. Such signaling properties are defined by the neurotransmitter system that a neuron uses to communicate with postsynaptic partners, the neurotransmitter receptor type used to receive input from presynaptic neurons, and, potentially, other sensory receptors that activate a neuron. Elucidating the mechanisms that coordinate synaptogenesis, neuronal activation, and neurotransmitter signaling in a postmitotic neuron represents one key approach to understanding how neurons develop as functional units. Using the SAB class of Caenorhabditis elegans motor neurons as a model system, we show here that the phylogenetically conserved COE-type transcription factor UNC-3 is required for synaptogenesis. UNC-3 directly controls the expression of the ADAMTS-like protein MADD-4/Punctin, a presynaptically secreted synapse-organizing molecule that clusters postsynaptic receptors. UNC-3 also controls the assembly of presynaptic specializations and ensures the coordinated expression of enzymes and transporters that define the cholinergic neurotransmitter identity of the SAB neurons. Furthermore, synaptic output properties of the SAB neurons are coordinated with neuronal activation and synaptic input, as evidenced by UNC-3 also regulating the expression of ionotropic neurotransmitter receptors and putative stretch receptors. Our study shows how synaptogenesis and distinct, function-defining signaling features of a postmitotic neuron are hardwired together through coordinated transcriptional control.

  3. Diffusion Monte Carlo in internal coordinates.

    Science.gov (United States)

    Petit, Andrew S; McCoy, Anne B

    2013-08-15

    An internal coordinate extension of diffusion Monte Carlo (DMC) is described as a first step toward a generalized reduced-dimensional DMC approach. The method places no constraints on the choice of internal coordinates other than the requirement that they all be independent. Using H(3)(+) and its isotopologues as model systems, the methodology is shown to be capable of successfully describing the ground state properties of molecules that undergo large amplitude, zero-point vibrational motions. Combining the approach developed here with the fixed-node approximation allows vibrationally excited states to be treated. Analysis of the ground state probability distribution is shown to provide important insights into the set of internal coordinates that are less strongly coupled and therefore more suitable for use as the nodal coordinates for the fixed-node DMC calculations. In particular, the curvilinear normal mode coordinates are found to provide reasonable nodal surfaces for the fundamentals of H(2)D(+) and D(2)H(+) despite both molecules being highly fluxional.

  4. Coordination and standardization of federal sedimentation activities

    Science.gov (United States)

    Glysson, G. Douglas; Gray, John R.

    1997-01-01

    In August 1964, the Bureau of the Budget issued Circular A-67 to set forth guidelines for the coordination of water-data acquisition activities throughout the Federal government. The U.S. Department of the Interior was assigned the task of implementing Circular A-67, which in turn redelegated this responsibility to the U.S. Geological Survey (USGS). Delegation of the lead responsibility for water-data coordination to the USGS occurred because of its historical role as the primary agency for water-data acquisition in the United States. To provide overall leadership for implementing the provisions of Circular A-67, the USGS established the Office of Water Data Coordination in the Water Resources Division (WRD). In addition, regional and district offices of the WRD were delegated responsibility for coordinating water data within their geographic areas of responsibility. On December 10, 1991, the Office of Management and Budget issued OMB Number Memorandum M-92-01, which expands the USGS's coordination role to encompass all water information. This includes data critical to water resources in the following categories: - surface- and ground-water quality and quantity,

  5. Communicating Processes with Data for Supervisory Coordination

    Directory of Open Access Journals (Sweden)

    Jasen Markovski

    2012-08-01

    Full Text Available We employ supervisory controllers to safely coordinate high-level discrete(-event behavior of distributed components of complex systems. Supervisory controllers observe discrete-event system behavior, make a decision on allowed activities, and communicate the control signals to the involved parties. Models of the supervisory controllers can be automatically synthesized based on formal models of the system components and a formalization of the safe coordination (control requirements. Based on the obtained models, code generation can be used to implement the supervisory controllers in software, on a PLC, or an embedded (microprocessor. In this article, we develop a process theory with data that supports a model-based systems engineering framework for supervisory coordination. We employ communication to distinguish between the different flows of information, i.e., observation and supervision, whereas we employ data to specify the coordination requirements more compactly, and to increase the expressivity of the framework. To illustrate the framework, we remodel an industrial case study involving coordination of maintenance procedures of a printing process of a high-tech Oce printer.

  6. A dynamic human motion: coordination analysis.

    Science.gov (United States)

    Pchelkin, Stepan; Shiriaev, Anton S; Freidovich, Leonid B; Mettin, Uwe; Gusev, Sergei V; Kwon, Woong; Paramonov, Leonid

    2015-02-01

    This article is concerned with the generic structure of the motion coordination system resulting from the application of the method of virtual holonomic constraints (VHCs) to the problem of the generation and robust execution of a dynamic humanlike motion by a humanoid robot. The motion coordination developed using VHCs is based on a motion generator equation, which is a scalar nonlinear differential equation of second order. It can be considered equivalent in function to a central pattern generator in living organisms. The relative time evolution of the degrees of freedom of a humanoid robot during a typical motion are specified by a set of coordination functions that uniquely define the overall pattern of the motion. This is comparable to a hypothesis on the existence of motion patterns in biomechanics. A robust control is derived based on a transverse linearization along the configuration manifold defined by the coordination functions. It is shown that the derived coordination and control architecture possesses excellent robustness properties. The analysis is performed on an example of a real human motion recorded in test experiments.

  7. Adaptation of coordination mechanisms to network structures

    Directory of Open Access Journals (Sweden)

    Herwig Mittermayer

    2008-12-01

    Full Text Available The coordination efficiency of Supply Chain Management is determined by two opposite poles: benefit from improved planning results and associated coordination cost. The centralization grade, applied coordination mechanisms and IT support have influence on both categories. Therefore three reference types are developed and subsequently detailed in business process models for different network structures. In a simulation study the performance of these organization forms are compared in a process plant network. Coordination benefit is observed if the planning mode is altered by means of a demand planning IT tool. Coordination cost is divided into structural and activity-dependent cost. The activity level rises when reactive planning iterations become necessary as a consequence of inconsistencies among planning levels. Some characteristic influence factors are considered to be a reason for uninfeasible planning. In this study the effect of capacity availability and stochastic machine downtimes is investigated in an uncertain demand situation. Results that if the network runs with high overcapacity, central planning is less likely to increase benefit enough to outweigh associated cost. Otherwise, if capacity constraints are crucial, a central planning mode is recommendable. When also unforeseen machine downtimes are low, the use of sophisticated IT tools is most profitable.

  8. The psychology of coordination and common knowledge.

    Science.gov (United States)

    Thomas, Kyle A; DeScioli, Peter; Haque, Omar Sultan; Pinker, Steven

    2014-10-01

    Research on human cooperation has concentrated on the puzzle of altruism, in which 1 actor incurs a cost to benefit another, and the psychology of reciprocity, which evolved to solve this problem. We examine the complementary puzzle of mutualism, in which actors can benefit each other simultaneously, and the psychology of coordination, which ensures such benefits. Coordination is facilitated by common knowledge: the recursive belief state in which A knows X, B knows X, A knows that B knows X, B knows that A knows X, ad infinitum. We test whether people are sensitive to common knowledge when deciding whether to engage in risky coordination. Participants decided between working alone for a certain profit and working together for a potentially higher profit that they would receive only if their partner made the same choice. Results showed that more participants attempted risky coordination when they and their prospective partner had common knowledge of the payoffs (broadcast over a loudspeaker) than when they had only shared knowledge (conveyed to both by a messenger) or private knowledge (revealed to each partner separately). These results support the hypothesis that people represent common knowledge as a distinct cognitive category that licenses them to coordinate with others for mutual gain. We discuss how this hypothesis can provide a unified explanation for diverse phenomena in human social life, including recursive mentalizing, performative speech acts, public protests, hypocrisy, and self-conscious emotional expressions.

  9. Developmental differences in childhood motor coordination predict adult alcohol dependence

    DEFF Research Database (Denmark)

    Manzardo, Ann M; Penick, Elizabeth C; Knop, Joachim

    2005-01-01

    BACKGROUND: The Danish Longitudinal Study of Alcoholism has identified a number of early biological indicators that predicted alcohol dependence 30 years later. In light of recent evidence linking deficits of the cerebellum to certain neuropsychiatric disorders often comorbid with alcoholism, we...... hypothesized that developmental deficits in the cerebellar vermis may also play a role in the initiation of adult alcohol dependence. The present study evaluated whether measures of motor development in the first year of life predict alcohol dependence three decades later. METHODS: A total of 241 subjects...... after birth as well as at 1 year of age. Muscle tone at birth and day 5 as well as 1-year measures of motor coordination--age to sitting, standing, and walking--were examined. A DSM-III-R diagnosis of alcohol dependence and a measure of lifetime problem drinking served as the 30-year outcome variables...

  10. 7 CFR 1794.11 - Apply NEPA early in the planning process.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Apply NEPA early in the planning process. 1794.11... National Environmental Policy Act § 1794.11 Apply NEPA early in the planning process. The environmental review process requires early coordination with and involvement of RUS. Applicants should consult...

  11. Obesity and Motor Coordination Ability in Taiwanese Children with and without Developmental Coordination Disorder

    Science.gov (United States)

    Zhu, Yi-Ching; Wu, Sheng K.; Cairney, John

    2011-01-01

    The purpose of this study was to investigate the associations between obesity and motor coordination ability in Taiwanese children with and without developmental coordination disorder (DCD). 2029 children (1078 boys, 951 girls) aged nine to ten years were chosen randomly from 14 elementary schools across Taiwan. We used bioelectrical impedance…

  12. Movement Coordination in Ball Catching: Comparison between Boys with and without Developmental Coordination Disorder

    Science.gov (United States)

    Przysucha, Eryk P.; Maraj, Brian K. V.

    2010-01-01

    This investigation examined the catching coordination of 12 boys (M age = 9.9 years, SD = 0.8) with and without Developmental Coordination Disorder (DCD; M age = 10.5 years, SD = 0.8), under different task constraints. Participants attempted a total of 60 catches in central and lateral locations, under blocked and randomized conditions. No effect…

  13. Coordinated Flexibility: How Initial Gaze Position Modulates Eye-Hand Coordination and Reaching

    Science.gov (United States)

    Adam, Jos J.; Buetti, Simona; Kerzel, Dirk

    2012-01-01

    Reaching to targets in space requires the coordination of eye and hand movements. In two experiments, we recorded eye and hand kinematics to examine the role of gaze position at target onset on eye-hand coordination and reaching performance. Experiment 1 showed that with eyes and hand aligned on the same peripheral start location, time lags…

  14. Novel antenna concepts via coordinate transformation

    Directory of Open Access Journals (Sweden)

    P.-H. Tichit

    2013-02-01

    Full Text Available Coordinate transformation is an emerging field which offers a powerful and unprecedented ability to manipulate and control electromagnetic waves. Using this tool, we demonstrate the design of novel antenna concepts by tailoring their radiation properties. The wave manipulation is enabled through the use of engineered dispersive composite metamaterials that realize the space coordinate transformation. Three types of antennas are considered for design: a directive, a beam steerable and a quasi-isotropic one. Numerical simulations together with experimental measurements are performed in order to validate the coordinate transformation concept. Near-field cartography and far-field pattern measurements performed on a fabricated prototype agree qualitatively with Finite Element Method (FEM simulations. It is shown that a particular radiation pattern can be tailored at ease into a desired one by modifying the electromagnetic properties of the space around radiator. This idea opens the way to novel antenna design techniques for various application domains such as the aeronautical and transport fields.

  15. Conflict as driver of pluricentric coordination

    DEFF Research Database (Denmark)

    Sørensen, Eva

    2014-01-01

    Governance theory and planning theory share a tendency to either overlook the role of conflicts in coordination processes or view them as a disruptive force that must be modified or neutralized. In effect, there is little research into the productive role of conflicts in constructing...... and reconstructing the institutional conditions that make coordination possible. The productive role of conflicts is particularly visible in times of radical change that calls for a recasting of the sedimented world views and practices of the involved actors, as well as the relationship between them. A case study...... of the formation of new pluricentric regional governance arenas in Denmark provides important insights into how conflicts contribute to a gradual recasting of the institutional conditions that make coordination possible....

  16. TIARA: Toward accelerator R&D coordination

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    The preparatory phase of the TIARA (Test Infrastructure and Accelerator Research Area) project has begun. In January, members from 11 research institutes in 8 European countries began a three-year collaboration intended to enhance, improve and structure R&D efforts in the area of accelerator science and technology in Europe.   Partly funded by the European Commission under its Seventh Framework Programme (FP7), the TIARA project is being coordinated by the CEA (Commissariat à l’Énergie Atomique et aux Energies Alternatives). “The aim of the project is to arrive at an organisational structure that will provide coordination for R&D efforts and associated infrastructures in the field of particle accelerators in Europe,” explains the CEA’s Céline Tanguy, project coordinator assistant. “The new structure, which we hope will be a durable one, will be set up at the end of the project’s preparatory phase....

  17. First-order Dyson coordinates and geometry.

    Science.gov (United States)

    Hermes, Matthew R; Hirata, So

    2013-08-15

    The mathematical constructs of the Dyson coordinates and geometry are introduced. The former are a unitary transformation of the normal coordinates and the anharmonic vibrational counterpart of the Dyson orbitals in electronic structure theory. The first-order Dyson coordinates bring the sums of the harmonic force constants and their first-order diagrammatic perturbation corrections (the first-order Dyson self-energy) to a diagonal form. The first-order Dyson geometry has no counterpart in electronic structure theory. It is the point on the potential energy surface at which the sums of the energy gradients and their first-order diagrammatic perturbation corrections vanish. It agrees with the vibrationally averaged geometry of vibrational self-consistent field (VSCF) theory in the bulk limit. These constructs provide a unified view of the relationship of VSCF and its diagrammatically size-consistent modifications as well as the self-consistent phonon method widely used in solid-state physics.

  18. Coordination: Neural, Behavioral and Social Dynamics

    CERN Document Server

    Fuchs, Armin

    2008-01-01

    One of the most striking features of Coordination Dynamics is its interdisciplinary character. The problems we are trying to solve in this field range from behavioral phenomena of interlimb coordination and coordination between stimuli and movements (perception-action tasks) through neural activation patterns that can be observed during these tasks to clinical applications and social behavior. It is not surprising that close collaboration among scientists from different fields as psychology, kinesiology, neurology and even physics are imperative to deal with the enormous difficulties we are facing when we try to understand a system as complex as the human brain. The chapters in this volume are not simply write-ups of the lectures given by the experts at the meeting but are written in a way that they give sufficient introductory information to be comprehensible and useful for all interested scientists and students.

  19. A Process Algebra for Supervisory Coordination

    CERN Document Server

    Baeten, Jos; van Hulst, Allan; Markovski, Jasen; 10.4204/EPTCS.60.3

    2011-01-01

    A supervisory controller controls and coordinates the behavior of different components of a complex machine by observing their discrete behaviour. Supervisory control theory studies automated synthesis of controller models, known as supervisors, based on formal models of the machine components and a formalization of the requirements. Subsequently, code generation can be used to implement this supervisor in software, on a PLC, or embedded microprocessor. In this article, we take a closer look at the control loop that couples the supervisory controller and the machine. We model both event-based and state-based observations using process algebra and bisimulation-based semantics. The main application area of supervisory control that we consider is coordination, referred to as supervisory coordination, and we give an academic and an industrial example, discussing the process-theoretic concepts employed.

  20. Coordinated discharge of a collection of batteries

    Energy Technology Data Exchange (ETDEWEB)

    Sastry, Shivakumar; Gimdogmus, Omer; Hartley, Tom T.; Veillette, Robert J. [Department of Electrical and Computer Engineering, The University of Akron, Akron, OH 44325-3904 (United States)

    2007-03-30

    Collections of batteries are used to supply energy to a variety of applications. By utilizing the energy in such a collection efficiently, we can improve the lifetime over which energy can be supplied to the application. We say that the discharge of a collection of batteries is coordinated when, at the end of discharge, the difference in the remaining capacity of individual batteries is small. This paper presents a decision-maker based on a goal-seeking formulation that coordinates the discharge of a collection of batteries. This formulation allows us to use a simple battery model and simple decision-making algorithms. We present results from MATLAB simulations that demonstrate the performance of the decision-maker when energy is drawn out of the collection in three different discharge scenarios. The new decision-maker consistently improves the discharge efficiency obtained using scheduling methods. Our results show that when the discharge is coordinated, the lifetime of the collection is extended. (author)

  1. Optimal coordinated voltage control of power systems

    Institute of Scientific and Technical Information of China (English)

    LI Yan-jun; HILL David J.; WU Tie-jun

    2006-01-01

    An immune algorithm solution is proposed in this paper to deal with the problem of optimal coordination of local physically based controllers in order to preserve or retain mid and long term voltage stability. This problem is in fact a global coordination control problem which involves not only sequencing and timing different control devices but also tuning the parameters of controllers. A multi-stage coordinated control scheme is presented, aiming at retaining good voltage levels with minimal control efforts and costs after severe disturbances in power systems. A self-pattern-recognized vaccination procedure is developed to transfer effective heuristic information into the new generation of solution candidates to speed up the convergence of the search procedure to global optima. An example of four bus power system case study is investigated to show the effectiveness and efficiency of the proposed algorithm, compared with several existing approaches such as differential dynamic programming and tree-search.

  2. On the existence of MSA coordinates

    CERN Document Server

    Hernández-Pastora, J L

    2009-01-01

    The static solutions of the axially symmetric vacuum Einstein equations with a finite number of Relativistic Multipole Moments are described by means of a function that can be written in the same analytic form as the Newtonian gravitational multipole potential. A family of so-called MSA (Multipole-Symmetry Adapted) coordinates are introduced and calculated at any multipole order to perform the transformation of the Weyl solutions. In analogy with a previous result obtained in Newtonian gravity, the existence of a symmetry of a certain system of differential equations leading to the determination of that kind of multipole solutions in General Relativity is explored. The relationship between the existence of this kind of coordinate and the symmetries mentioned is proved for some cases, and the characterization of the MSA system of coordinates by means of this relationship is discussed.

  3. Coordinated Voltage Control of Active Distribution Network

    Directory of Open Access Journals (Sweden)

    Xie Jiang

    2016-01-01

    Full Text Available This paper presents a centralized coordinated voltage control method for active distribution network to solve off-limit problem of voltage after incorporation of distributed generation (DG. The proposed method consists of two parts, it coordinated primal-dual interior point method-based voltage regulation schemes of DG reactive powers and capacitors with centralized on-load tap changer (OLTC controlling method which utilizes system’s maximum and minimum voltages, to improve the qualified rate of voltage and reduce the operation numbers of OLTC. The proposed coordination has considered the cost of capacitors. The method is tested using a radial edited IEEE-33 nodes distribution network which is modelled using MATLAB.

  4. Early Astronomy

    Science.gov (United States)

    Thurston, Hugh

    The earliest investigations that can be called scientific are concerned with the sky: they are the beginnings of astronomy. Many early civilizations produced astronomical texts, and several cultures that left no written records left monuments and artifacts-ranging from rock paintings to Stonehenge-that show a clear interest in astronomy. Civilizations in China, Mesopotamia, India and Greece had highly developed astronomies, and the astronomy of the Mayas was by no means negligible. Greek astronomy, as developed by the medieval Arab philosophers, evolved into the astronomy of Copernicus. This displaced the earth from the central stationary position that almost all earlier astronomies had assumed. Soon thereafter, in the first decades of the seventeenth century, Kepler found the true shape of the planetary orbits and Galileo introduced the telescope for astronomical observations.

  5. The relationship between segmental coordination, agility and physical activity in adolescents

    Directory of Open Access Journals (Sweden)

    Eliseo García Cantó

    2015-06-01

    Full Text Available Motor competence (MC may be related to youth physical activity (PA level. In the last few years, MC has been studied as a possible determinant of children PA level, but has not been widely studied in adolescents. To analyze the relationship between MC and PA level 533 adolescents (271 men and 261 women from the southeast of Spain were assessed. To register weekly PA was used the International Physical Activity Questionnaire (IPAQ and for the MC, four coordination tests including throw and catch test, eye-hand and eye-foot coordination tests and agility circuit. Data were analyzed using ANOVA and binary logistic regression. The overall MC is consistently related with PA level. Eye-hand coordination test and the agility test define more accurately the tendency to high PA level. Programs to promote PA and focused on MC should be emphasized from early ages to adolescence.

  6. Recognizing Patterns In Log-Polar Coordinates

    Science.gov (United States)

    Weiman, Carl F. R.

    1992-01-01

    Log-Hough transform is basis of improved method for recognition of patterns - particularly, straight lines - in noisy images. Takes advantage of rotational and scale invariance of mapping from Cartesian to log-polar coordinates, and offers economy of representation and computation. Unification of iconic and Hough domains simplifies computations in recognition and eliminates erroneous quantization of slopes attributable to finite spacing of Cartesian coordinate grid of classical Hough transform. Equally efficient recognizing curves. Log-Hough transform more amenable to massively parallel computing architectures than traditional Cartesian Hough transform. "In-place" nature makes it possible to apply local pixel-neighborhood processing.

  7. Coordination under the Shadow of Career Concerns

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht

    To innovate, firms require their employees to develop novel ideas and to coordinate with each other to turn these ideas into products, services or business strategies. Because the quality of implemented designs that employees are associated with affects their labor market opportunities, career...... concerns arise that can both be ‘good’ (enhancing incentives for effort in developing ideas) and ‘bad’ (preventing voluntary coordination). Depending on the strength of career concerns, either group-based incentives or team production are optimal. This finding provides a possible link between the increased...

  8. Coordination under the Shadow of Career Concerns

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht

    2010-01-01

    A firm's innovation process requires employees to develop novel ideas and to coordinate with each other to turn the tacit knowledge embodying these ideas into better products and services. Such work outcomes provide signals about employees' abilities to the labor market, and therefore career...... concerns arise. The effects of career concerns can both be 'good' (enhancing incentives for effort in developing ideas) and 'bad' (preventing voluntary coordination). Our model shows how a firm can take these conflicting forces into account through the design of its explicit incentive system and the way...

  9. Investigation on Tidal Components in GPS Coordinates

    Science.gov (United States)

    Araszkiewicz, Andrzej; Bogusz, Janusz; Figurski, Mariusz

    2009-01-01

    This paper presents analyses on the GPS coordinates from sub-diurnal solutions of EPN data provided by Warsaw Military University of Technology. The aim of this research is to investigate the way the tidal models used in Bernese software (solid Earth and ocean tides as well) fit to the individual conditions of EPN stations. The 1-hour solution technique of GPS data processing was utilized to obtain coordinates of above 70 EPN stations. Additionally several Polish permanent sites with clearly seen oscillations were examined. This processing technique allowed us to recognize diurnal and sub-diurnal residual oscillations which could be next utilized for validation of the tidal models.

  10. Penta-coordinate phosphorous compounds and biochemistry

    Institute of Scientific and Technical Information of China (English)

    林长学; 李艳梅; 成昌梅; 韩波; 万荣; 冯亚兵; 赵玉芬

    2002-01-01

    The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleoside-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipeptide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.

  11. Dynamical modelling of coordinated multiple robot systems

    Science.gov (United States)

    Hayati, Samad

    1987-01-01

    The state of the art in the modeling of the dynamics of coordinated multiple robot manipulators is summarized and various problems related to this subject are discussed. It is recognized that dynamics modeling is a component used in the design of controllers for multiple cooperating robots. As such, the discussion addresses some problems related to the control of multiple robots. The techniques used to date in the modeling of closed kinematic chains are summarized. Various efforts made to date for the control of coordinated multiple manipulators is summarized.

  12. Coordinate mapping of hyolaryngeal mechanics in swallowing.

    Science.gov (United States)

    Thompson, Thomas Z; Obeidin, Farres; Davidoff, Alisa A; Hightower, Cody L; Johnson, Christohper Z; Rice, Sonya L; Sokolove, Rebecca-Lyn; Taylor, Brandon K; Tuck, John M; Pearson, William G

    2014-05-06

    Characterizing hyolaryngeal movement is important to dysphagia research. Prior methods require multiple measurements to obtain one kinematic measurement whereas coordinate mapping of hyolaryngeal mechanics using Modified Barium Swallow (MBS) uses one set of coordinates to calculate multiple variables of interest. For demonstration purposes, ten kinematic measurements were generated from one set of coordinates to determine differences in swallowing two different bolus types. Calculations of hyoid excursion against the vertebrae and mandible are correlated to determine the importance of axes of reference. To demonstrate coordinate mapping methodology, 40 MBS studies were randomly selected from a dataset of healthy normal subjects with no known swallowing impairment. A 5 ml thin-liquid bolus and a 5 ml pudding swallows were measured from each subject. Nine coordinates, mapping the cranial base, mandible, vertebrae and elements of the hyolaryngeal complex, were recorded at the frames of minimum and maximum hyolaryngeal excursion. Coordinates were mathematically converted into ten variables of hyolaryngeal mechanics. Inter-rater reliability was evaluated by Intraclass correlation coefficients (ICC). Two-tailed t-tests were used to evaluate differences in kinematics by bolus viscosity. Hyoid excursion measurements against different axes of reference were correlated. Inter-rater reliability among six raters for the 18 coordinates ranged from ICC = 0.90 - 0.97. A slate of ten kinematic measurements was compared by subject between the six raters. One outlier was rejected, and the mean of the remaining reliability scores was ICC = 0.91, 0.84 - 0.96, 95% CI. Two-tailed t-tests with Bonferroni corrections comparing ten kinematic variables (5 ml thin-liquid vs. 5 ml pudding swallows) showed statistically significant differences in hyoid excursion, superior laryngeal movement, and pharyngeal shortening (p Pearson correlations of hyoid excursion measurements from two different

  13. Coordinate transformations and matter waves cloaking

    Science.gov (United States)

    Mohammadi, G. R.; Moghaddam, A. G.; Mohammadkhani, R.

    2016-03-01

    Transformation method provides an efficient tool to control wave propagation inside the materials. Using the coordinate transformation approach, we study invisibility cloaks with sphere, cylinder and ellipsoid structures for electronic waves propagation. The underlying physics behind this investigation is the fact that Schrödinger equation with position dependent mass tensor and potentials has a covariant form which follows the coordinate transformation. Using this technique we obtain the exact spatial form of the mass tensor and potentials for a variety of cloaks with different shapes.

  14. Coordinated intelligent adaptive control of legged robots

    Science.gov (United States)

    McLauchlan, Lifford; Mehrübeoğlu, Mehrübe

    2006-05-01

    In planetary or hazardous environment exploration, there will be unforseen environmental circumstances which can not be planned. To overcome telerobotic control issues due to communication delays, autonomous robot control becomes necessary. Autonomously controlled landers and instrumentation can be used in exploration, such as lunar and martian missions. However, wheeled robots have difficulty in exploring uneven terrain; thus, legged robots can be used in such situations. This research develops intelligent and adaptive control of mobile robots to perform functions such as environmental exploration in coordination and obstacle avoidance. The coordinated control is demonstrated in simulations.

  15. Modeling Coordination Problems in a Music Ensemble

    DEFF Research Database (Denmark)

    Frimodt-Møller, Søren R.

    2008-01-01

    This paper considers in general terms, how musicians are able to coordinate through rational choices in a situation of (temporary) doubt in an ensemble performance. A fictitious example involving a 5-bar development in an unknown piece of music is analyzed in terms of epistemic logic, more...... specifically a multi-agent system, where it is shown that perfect coordination can only be certain to take place if the musicians have common knowledge of certain rules of the composition. We subsequently argue, however, that the musicians need not agree on the central features of the piece of music in order...

  16. Penta-coordinate phosphorous compounds and biochemistry

    Institute of Scientific and Technical Information of China (English)

    林长学; 韩波; 赵玉芬; 万荣; 李艳梅; 冯亚兵; 成昌梅

    2002-01-01

    The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleo-side-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipep-tide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.

  17. 33 CFR 169.10 - What geographic coordinates are used?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What geographic coordinates are... coordinates are used? Geographic coordinates expressed in terms of latitude or longitude, or both, are not... of 1983 (NAD 83), unless such geographic coordinates are expressly labeled NAD 83....

  18. 34 CFR 303.23 - Service coordination (case management).

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Service coordination (case management). 303.23 Section... Service coordination (case management). (a) General. (1) As used in this part, except in § 303.12(d)(11), service coordination means the activities carried out by a service coordinator to assist and enable...

  19. Semantics and Syntax of Non-Standard Coordination

    Science.gov (United States)

    Paperno, Denis

    2012-01-01

    This dissertation explores the diversity and unity of coordination constructions in natural language. Following the goal of bridging syntactic typology with formal semantics, it takes the typological variation in NP coordination patterns as a challenge for semantic theory. Hybrid Coordination in Russian and Comitative Coordination in…

  20. Individual contributions to (re-)stabilizing interpersonal movement coordination

    NARCIS (Netherlands)

    Peper, C. (Lieke) E.; Stins, John F.; de Poel, Harjo J.

    2013-01-01

    Interpersonal movement coordination is characterized by stable coordination patterns. We examined the extent to which the two individuals within a dyad contributed to the stabilization of a shared coordination pattern. Within each dyad, the two participants coordinated rhythmic movements of their ri

  1. Coordinating Post-Tsunami Field Surveys in the us

    Science.gov (United States)

    Kong, L. S.; Chiesa, C.; Dunbar, P. K.; Huart, J.; Richards, K.; Shulters, M.; Stein, A.; Tamura, G.; Wilson, R. I.; Young, E.

    2011-12-01

    Post-tsunami scientific field surveys are critical for improving the understanding of tsunamis and developing tools and programs to mitigate their effects. After a destructive tsunami, international, national, and local tsunami scientists need to gather information, much of which is perishable or degrades significantly with time. An influx of researchers can put stress on countries already overwhelmed by humanitarian response to the disaster and by the demands of emergency management and other support agencies. In the United States, in addition to university research scientists, government agencies such as the National Oceanic and Atmospheric Administration (NOAA), the U.S. Geologic Survey (USGS), and state/territorial emergency management agencies and geological surveys endeavor to collect physical and social science data to better understand the physics of tsunamis and the impact they have on coastal communities and ecosystems. After a Presidential Major Disaster Declaration, the Federal Emergency Management Agency (FEMA) Joint Field Office works with state/territory emergency management agencies to coordinate response to disasters. In the short-term, the collection and immediate sharing of data enable decision-making that better organizes and deploys often-limited resources to the areas most critically in need of response; and in the long-term, improves recovery planning that will mitigate the losses from the next tsunami. Recent tsunamis have emphasized the need for improved coordination of data collection among scientists and federal, state, and local emergency managers. Improved coordination will ensure data collection efforts are carried out in a safe, secure, efficient, and timely manner. To improve coordination of activities that will better integrate the scientific investigations with government response, the US National Tsunami Hazard Mitigation Program and Pacific Risk Management 'Ohana (PRiMO) are working together to develop a consistent framework for

  2. Inter-Organizational Coordination, IT Support, and Environment

    Institute of Scientific and Technical Information of China (English)

    QU Gang; JI Shaobo; MIN Qingfei

    2008-01-01

    Manufacturing organizations must know how to deal with uncertainty, manage environmental impact, effectively coordinate with suppliers, and use information technology (IT) to support coordination. Applying cybernetics and information processing theories, this study explores the relationship between organizational environment, inter-organizational coordination, IT support, and the effectiveness of inter-organizational coordination. Using the case study method, data was collected from six manufacturing firms in China. The results show that inter-organizational system adoption is affected by organizational environment and is related to the management of inter-organizational coordination. Coordination and IT application affect the performance of inter-organizational coordination.

  3. Effective coordination and cooperation between ecological risk assessments and natural resource damage assessments: a new synthesis.

    Science.gov (United States)

    Gouguet, Ronald G; Charters, David W; Champagne, Larry F; Davis, Mark; Desvouges, William; Durda, Judi L; Hyatt, William H; Jacobson, Rachel; Kapustka, Larry; Longoria, Rose M

    2009-10-01

    Although ecological risk assessments (ERAs) and natural resource damage assessments (NRDAs) are performed under different statutory and regulatory authorities, primarily the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), as currently practiced, the activities typically overlap. ERAs performed as part of the response process (typically by the US Environmental Protection Agency [USEPA]) should be closely coordinated with the natural resource trustees' (trustees') NRDAs. Trustees should actively participate in the early stages of the remedial investigation (RI) and work with USEPA, including the potentially responsible parties (PRPs), when appropriate, to coordinate NRDA data needs with those of the RI. Close coordination can present opportunities to avoid inefficiencies, such as unnecessary resampling or duplicate data gathering, and provide the opportunity to fulfill both process requirements with a few well-designed investigations. Early identification of opportunities for practical combined assessment can save money and time as the restoration process proceeds and facilitate a cooperative resolution of the entire site's CERCLA liability. The Society of Environmental Toxicology and Chemistry (SETAC) convened an invited workshop (August 2008) to address coordination between ERA and NRDA efforts. This paper presents the findings and conclusions of the Framework Work Group, which considered technical issues common to each process, while mindful of the current legal and policy landscape, and developed recommendations for future practice.

  4. Coordinated action in a heterogeneous rescue team

    NARCIS (Netherlands)

    F. Alnajar; H. Nijhuis; A. Visser

    2009-01-01

    In this paper we describe a new approach to make use of a heterogeneous robot team for the RoboCup Rescue League Virtual Robot competition. We will demonstrate coordinated action between a flying and a ground robot. The flying robot is used for fast exploration and allows the operator to find the pl

  5. 78 FR 34035 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-06-06

    .... Written comments may be submited by mail to Attn: Maya Solomon, 1400 Independence Ave. SW., Mailstop 1123.../spf/coop/frcc/ . Public participants are encouraged to RSVP to Maya Solomon via phone at 202-205-1376... support materials. FOR FURTHER INFORMATION CONTACT: Maya Solomon, Forest Resource Coordinating...

  6. Adsorption Kinetics in Nanoscale Porous Coordination Polymers

    Energy Technology Data Exchange (ETDEWEB)

    Nune, Satish K.; Thallapally, Praveen K.; McGrail, Benard Peter; Annapureddy, Harsha V. R.; Dang, Liem X.; Mei, Donghai; Karri, Naveen; Alvine, Kyle J.; Olszta, Matthew J.; Arey, Bruce W.; Dohnalkova, Alice

    2015-10-07

    Nanoscale porous coordination polymers were synthesized using simple wet chemical method. The effect of various polymer surfactants on colloidal stability and shape selectivity was investigated. Our results suggest that the nanoparticles exhibited significantly improved adsorption kinetics compared to bulk crystals due to decreased diffusion path lengths and preferred crystal plane interaction.

  7. Children Use Salience to Solve Coordination Problems

    Science.gov (United States)

    Grueneisen, Sebastian; Wyman, Emily; Tomasello, Michael

    2015-01-01

    Humans are routinely required to coordinate with others. When communication is not possible, adults often achieve this by using salient cues in the environment (e.g. going to the Eiffel Tower, as an obvious meeting point). To explore the development of this capacity, we presented dyads of 3-, 5-, and 8-year-olds (N = 144) with a coordination…

  8. Coordinating health care: lessons from Norway

    Directory of Open Access Journals (Sweden)

    Trond Tjerbo

    2005-11-01

    Full Text Available Objective: What influences the coordination of care between general practitioners and hospitals? In this paper, general practitioner satisfaction with hospital—GP interaction is revealed, and related to several background variables. Method: A questionnaire was sent to all general practitioners in Norway (3388, asking their opinion on the interaction and coordination of health care in their district. A second questionnaire was sent to all the somatic hospitals in Norway (59 regarding formal routines and structures. The results were analysed using ordinary least squares regression. Results: General practitioners tend to be less satisfied with the coordination of care when their primary hospital is large and cost-effective with a high share of elderly patients. Together with the degree to which the general practitioner is involved in arenas where hospital physicians and general practitioners interact, these factors turned out to be good predictors of general practitioner satisfaction. Implication: To improve coordination between general practitioners and specialists, one should focus upon the structural traits within the hospitals in different regions as well as creating common arenas where the physicians can interact.

  9. Static balance and developmental coordination disorder

    NARCIS (Netherlands)

    Geuze, RH

    2003-01-01

    The development of static balance is a basic characteristic of normal motor development. Most of the developmental motor tests include a measure of static balance. Children with a developmental coordination disorder (DCD) often fail this item. Twenty-four children at risk for DCD with balance proble

  10. Deriving force field parameters for coordination complexes

    DEFF Research Database (Denmark)

    Norrby, Per-Ola; Brandt, Peter

    2001-01-01

    The process of deriving molecular mechanics force fields for coordination complexes is outlined. Force field basics are introduced with an emphasis on special requirements for metal complexes. The review is then focused on how to set up the initial model, define the target, refine the parameters,...

  11. Existence of frozen-in coordinate systems

    Science.gov (United States)

    Chertkov, A. D.

    1995-01-01

    The 'frozen-in' coordinate systems were first introduced in the works on 'reconnection' and 'magnetic barrier' theories (see review by M.l.Pudovkin and V.S.Semenov, Space Sci. Rev. 41,1 1985). The idea was to utilize the mathematical apparatus developed for 'general relativity' theory to simplify obtaining solutions to the ideal MHD equations set. Magnetic field (B), plasma velocity (v), and their vector product were used as coordinate vectors. But there exist no stationary solutions of ideal MHD set that satisfies the required boundary conditions at infinity (A.D.Chertkov, Solar Wind Seven Conf.,Pergamon Press,1992,165) having non-zero vector product of v and B where v and B originate from the same sphere. The existence of a solution is the hidden mine of the mentioned theories. The solution is constructed in the coordinate system, which is unknown and indeterminate before obtaining this solution. A substitution of the final solution must be done directly into the initial MHD set in order to check the method. One can demonstrate that 'solutions' of Petschek's problem, obtained by 'frozen-in' coordinate systems, does not satisfy just the 'frozen-in' equation, i.e. induction equation. It stems from the fact that Petschek's 're-connection' model, treated as a boundary problem, is over determined. This problem was incorrectly formulated.

  12. [Backup territorial coordination, nursing roles and skills].

    Science.gov (United States)

    Benyahia, Amina; Abraham, Éliane

    2016-06-01

    Backup territorial coordination provides accompaniment and support for professionals who work with the fragile elderly people in an area. It aligns the sanitary, medical-social and social approaches, and mobilizes useful resources to optimize the treatment pathway. It has been implemented in the Nancy urban area by an operational team including nurses and a geriatric physician.

  13. Influence of aging on bimanual coordination control.

    Science.gov (United States)

    Lin, Chueh-Ho; Chou, Li-Wei; Wei, Shun-Hwa; Lieu, Fu-Kong; Chiang, Shang-Lin; Sung, Wen-Hsu

    2014-05-01

    Degeneration in the neuromuscular system due to aging can affect daily activities that need to be controlled by bimanual coordination with both hands. However, little is known about the influence of aging on grip strength and bimanual coordination control between hands. The purpose of this study was to investigate the influence of aging on the maximum grip force output and capacity of coordination control of two hands. Ten healthy elderly and 21 young adults were recruited and asked to execute maximum grip force tests and bimanual coordination control tasks with reciprocal grasping, holding, and releasing of a dynamometer with both hands at three target force levels (10, 20 and 40% maximal voluntary contraction, MVC). Compared with the young group, the maximum grip force of the hands of the elderly group was significantly lower by 77.5% (pelderly adults also displayed a significantly longer alternating time control in the dominant to non-dominant and non-dominant to dominant hands at the 20% MVC target force level (pcoordination control of two hands, which may lead to difficulty with the execution of daily activities requiring both hands.

  14. On hydrostatic flows in isentropic coordinates

    NARCIS (Netherlands)

    Bokhove, Onno

    2000-01-01

    The hydrostatic primitive equations of motion which have been used in large-scale weather prediction and climate modelling over the last few decades are analysed with variational methods in an isentropic Eulerian framework. The use of material isentropic coordinates for the Eulerian hydrostatic equa

  15. Acting together: Mechanisms of intentional coordination

    NARCIS (Netherlands)

    Vesper, C.

    2013-01-01

    Coordination with other people is a central part of human life. Whenever we wave at a friend, help our neighbor carry her shopping bag up the stairs, dance tango or talk to one another, we need to take another person’s actions into account and accordingly adapt how we do our part in the interaction.

  16. Cost Allocation as a Coordination Mechanism

    NARCIS (Netherlands)

    Diaw, K.

    2003-01-01

    This paper shows that cost allocation can endogenously arise as a coordination mechanism in a decentralized firm.This result is derived in a setting with multiple (internally supplied) resources shared by multiple users, which constitutes a departure from previous literature.While standard cost allo

  17. Coordinated action in a heterogeneous rescue team

    NARCIS (Netherlands)

    Alnajar, F.; Nijhuis, H.; Visser, A.

    2010-01-01

    In this paper we describe a new approach to make use of a heterogeneous robot team for the RoboCup Rescue League Virtual Robot competition. We will demonstrate coordinated action between a flying and a ground robot. The flying robot is used for fast exploration and allows the operator to find the pl

  18. Contemplations on Dirac's equation in quaternionic coordinates

    Science.gov (United States)

    Schuricht, Dirk; Greiter, Martin

    2004-11-01

    A formulation of Dirac's equation using complex-quaternionic coordinates appears to yield an enormous gain in formal elegance, as there is no longer any need to invoke Dirac matrices. This formulation, however, entails several peculiarities, which we investigate and attempt to interpret.

  19. Neuromuscular Control and Coordination during Cycling

    Science.gov (United States)

    Li, Li

    2004-01-01

    The neuromuscular control aspect of cycling has been investigated through the effects of modifying posture and cadence. These studies show that changing posture has a more profound influence on neuromuscular coordination than does changing slope. Most of the changes with standing posture occur late in the downstroke: increased ankle and knee joint…

  20. Mechanical signaling coordinates the embryonic heart

    Science.gov (United States)

    Chiou, Kevin; Rocks, Jason; Prosser, Benjamin; Discher, Dennis; Liu, Andrea

    The heart is an active material which relies on robust signaling mechanisms between cells in order to produce well-timed, coordinated beats. Heart tissue is composed primarily of active heart muscle cells (cardiomyocytes) embedded in a passive extracellular matrix. During a heartbeat, cardiomyocyte contractions are coordinated across the heart to form a wavefront that propagates through the tissue to pump blood. In the adult heart, this contractile wave is coordinated via intercellular electrical signaling.Here we present theoretical and experimental evidence for mechanical coordination of embryonic heartbeats. We model cardiomyocytes as mechanically excitable Eshelby inclusions embedded in an overdamped elastic-fluid biphasic medium. For physiological parameters, this model replicates recent experimental measurements of the contractile wavefront which are not captured by electrical signaling models. We additionally challenge our model by pharmacologically blocking gap junctions, inhibiting electrical signaling between myocytes. We find that while adult hearts stop beating almost immediately after gap junctions are blocked, embryonic hearts continue beating even at significantly higher concentrations, providing strong support for a mechanical signaling mechanism.

  1. Coordination of a parallel proposition solver

    NARCIS (Netherlands)

    Everaars, C.T.H.; Lisser, B.

    1998-01-01

    In this paper we describe an experiment in which {sc Manifold is used to coordinate the interprocess communication in a parallelized proposition solver. {sc Manifold is very well suited for applications involving dynamic process creation and dynamically changing (ir)regular communication patterns am

  2. The coordinate systems used in visual tracking

    NARCIS (Netherlands)

    Howe, P.D.L.; Pinto, Y.; Horowitz, T.S.

    2010-01-01

    Tracking moving objects is a fundamental attentional operation. Here we ask which coordinate system is used to track objects: retinal (retinotopic), scene-centered (allocentric), or both? Observers tracked three of six disks that were confined to move within an imaginary square. By moving either the

  3. 23 CFR 635.307 - Coordination.

    Science.gov (United States)

    2010-04-01

    ... accomplished in accordance with provisions of the following: (1) 23 CFR part 140, subpart I; (2) 23 CFR part 646, subpart B; (3) 23 CFR 710.403; and (4) 23 CFR part 645, subpart A. ... 23 Highways 1 2010-04-01 2010-04-01 false Coordination. 635.307 Section 635.307 Highways...

  4. The coordinate system for force control.

    Science.gov (United States)

    Saha, Devjani J; Hu, Xiao; Perreault, Eric; Murray, Wendy; Mussa-Ivaldi, Ferdinando A

    2015-03-01

    The primary objective of this study was to establish the coordinate frame for force control by observing how parameters of force that are not explicitly specified by a motor task vary across the workspace. We asked subjects to apply a force of a specific magnitude with their hand. Subjects could complete the task by applying forces in any direction of their choice in the transverse plane. They were tested with the arm in seven different configurations. To estimate whether contact forces are represented in extrinsic or intrinsic coordinates, we applied the parallel transport method of differential geometry to the net joint torques applied during the task. This approach allowed us to compare the force variability observed at different arm configurations with the force variability that would be expected if the control system were applying an invariant pattern of joint torques at the tested configurations. The results indicate that for the majority of the subjects, the predominant pattern was consistent with an invariant representation in joint coordinates. However, two out of eleven subjects also demonstrated a preference for extrinsic representation. These findings suggest that the central nervous system can represent contact forces in both coordinate frames, with a prevalence toward intrinsic representations.

  5. Traceability and uncertainty estimation in coordinate metrology

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Savio, Enrico; De Chiffre, Leonardo

    2001-01-01

    are required. Depending on the requirements for uncertainty level, different approaches may be adopted to achieve traceability. Especially in the case of complex measurement situations and workpieces the procedures are not trivial. This paper discusses the establishment of traceability in coordinate metrology...

  6. Coordinate Metrology by Traceable Computed Tomography

    DEFF Research Database (Denmark)

    Müller, Pavel

    metrology and coordinate metrology and is currently becoming more and more important measuring technique for dimensional measurements. This is mainly due to the fact that with CT, a complete three-dimensional model of the scanned part is in a relatively short time visualized using a computer...

  7. Dynamic network structure of interhemispheric coordination.

    Science.gov (United States)

    Doron, Karl W; Bassett, Danielle S; Gazzaniga, Michael S

    2012-11-13

    Fifty years ago Gazzaniga and coworkers published a seminal article that discussed the separate roles of the cerebral hemispheres in humans. Today, the study of interhemispheric communication is facilitated by a battery of novel data analysis techniques drawn from across disciplinary boundaries, including dynamic systems theory and network theory. These techniques enable the characterization of dynamic changes in the brain's functional connectivity, thereby providing an unprecedented means of decoding interhemispheric communication. Here, we illustrate the use of these techniques to examine interhemispheric coordination in healthy human participants performing a split visual field experiment in which they process lexical stimuli. We find that interhemispheric coordination is greater when lexical information is introduced to the right hemisphere and must subsequently be transferred to the left hemisphere for language processing than when it is directly introduced to the language-dominant (left) hemisphere. Further, we find that putative functional modules defined by coherent interhemispheric coordination come online in a transient manner, highlighting the underlying dynamic nature of brain communication. Our work illustrates that recently developed dynamic, network-based analysis techniques can provide novel and previously unapproachable insights into the role of interhemispheric coordination in cognition.

  8. Modified triplectic quantization in general coordinates

    CERN Document Server

    Geyer, B

    2003-01-01

    We present an extension of previous results (hep-th/0105215)on the quantization of general gauge theories within the BRST-antBRST invatiant Lagrangian scheme in general coordinates, namely, we consider the case when the base manifold of fields and antifields is a supermanifold desribed in terms of both bosonic and fermionic variables.

  9. Extended BRST quantization in general coordinates

    CERN Document Server

    Geyer, B; Nersessian, A B

    2002-01-01

    We propose an extended BRST invariant Lagrangian quantization scheme of general gauge theories based on explicit realization of "modified triplectic algebra" in general coordinates. All the known Lagrangian quantization schemes based on the extended BRST symmetry are obtained by specifying the (free) parameters of that method.

  10. Anomalous Bimanual Coordination among Dyslexic Boys.

    Science.gov (United States)

    Gladstone, Marshall; And Others

    1989-01-01

    To test for interhemispheric difficulties associated with dyslexia, this study assessed bimanual coordination in dyslexic and nondisabled boys using an Etch-a-Sketch-like task. Dyslexics showed significant impairments on mirror movements, and often unknowingly reverted to parallel movements when visual feedback was removed. (RH)

  11. Developmental coordination disorder: evaluation and treatment.

    NARCIS (Netherlands)

    Leemrijse, C.

    2003-01-01

    A child's popularity is often related to his or her proficiency in sports and games, and children value physical competence highly. The movement difficulties of children with developmental coordination disorder (DCD) often invite ridicule from their peers. Children with DCD have a poor motor perform

  12. Certified standards and vertical coordination in aquaculture

    DEFF Research Database (Denmark)

    Trifkovic, Neda

    2014-01-01

    This paper explores the interaction between food standards and vertical coordination in the Vietnamese pangasius sector. For farmers and processors alike, the adoption of standards is motivated by a desire to improve market access by ensuring high quality supply. Instead of encouraging the applic...

  13. 75 FR 69573 - Export Enforcement Coordination Center

    Science.gov (United States)

    2010-11-15

    ..., employees, or agents, or any other person. (Presidential Sig.) THE WHITE HOUSE, November 9, 2010. [FR Doc... Documents#0;#0; ] Executive Order 13558 of November 9, 2010 Export Enforcement Coordination Center By the... Homeland Security for administrative purposes, an interagency Federal Export Enforcement...

  14. Innovative coordination of agribusiness chains and networks

    NARCIS (Netherlands)

    Wubben, E.F.M.; Hagelaar, J.L.F.

    2009-01-01

    To facilitate scientifically grounded innovative forms of strategic network coordination, this paper integrates two major bodies of literature on competitive advantage. The two bodies of literature are the industry-oriented outside-in approach, and the competence-oriented inside-out approach, here h

  15. Coordinating Council. Ninth Meeting: Total Quality Management

    Science.gov (United States)

    1992-01-01

    This report summarizes the 9th meeting of the STI Coordinating Council. The council listened to the speakers' understanding of Total Quality Management (TQM) principles and heard stories of successful applications of these principles. Definitions of quality stated were focused on customer satisfaction. Reports presented by the speakers are also included.

  16. The brave new world of coordination frameworks.

    Science.gov (United States)

    Champness, Neil R

    2013-01-14

    In 1994 the field of coordination frameworks was still in its infancy and yet to give birth to its offspring research field of metal-organic frameworks (MOFs). Studies by Zaworotko and Ciani served to illustrate both the simplicity and the complexity of these remarkable structures.

  17. Coordinated Collaboration between Heterogeneous Distributed Energy Resources

    Directory of Open Access Journals (Sweden)

    Shahin Abdollahy

    2014-01-01

    Full Text Available A power distribution feeder, where a heterogeneous set of distributed energy resources is deployed, is examined by simulation. The energy resources include PV, battery storage, natural gas GenSet, fuel cells, and active thermal storage for commercial buildings. The resource scenario considered is one that may exist in a not too distant future. Two cases of interaction between different resources are examined. One interaction involves a GenSet used to partially offset the duty cycle of a smoothing battery connected to a large PV system. The other example involves the coordination of twenty thermal storage devices, each associated with a commercial building. Storage devices are intended to provide maximum benefit to the building, but it is shown that this can have a deleterious effect on the overall system, unless the action of the individual storage devices is coordinated. A network based approach is also introduced to calculate some type of effectiveness metric to all available resources which take part in coordinated operation. The main finding is that it is possible to achieve synergy between DERs on a system; however this required a unified strategy to coordinate the action of all devices in a decentralized way.

  18. Ytterbium Coordination Polymer with Four Different Coordination Numbers:The First Structural Characterization of Lanthanide Phthalate Complex

    Institute of Scientific and Technical Information of China (English)

    万永红; 金林培; 等

    2002-01-01

    The novel ytterbium coordination polymer is a t4wo-dimensional framework in which the central metal ions have four different coordination numbers and form four kinds of coordination poly-hedra,The four kinds of coordination polyhedra connect into infinite chains by sharing oxygen atoms.

  19. Early Home Supported Discharge of Stroke Patients:

    DEFF Research Database (Denmark)

    Larsen, Torben; Olsen, T. Skyhøj; Sørensen, Jan

    2006-01-01

    OBJECTIVES: A comprehensive and systematic assessment (HTA) of early home-supported discharge by a multidisciplinary team that plans, coordinates, and delivers care at home (EHSD) was undertaken and the results were compared with that of conventional rehabilitation at stroke units. METHODS......: A systematic literature search for randomized trials (RCTs) on "early supported discharge" was closed in April 2005. RCTs on EHSD without information on (i) death or institution at follow-up, (ii) change in Barthél Index, (iii) length of hospital stay, (iv) intensity of home rehabilitation, or (v) baseline...

  20. Distributed sensor coordination for advanced energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Tumer, Kagan [Oregon State Univ., Corvallis, OR (United States). School of Mechanical, Industrial and Manufacturing Engineering

    2015-03-12

    Motivation: The ability to collect key system level information is critical to the safe, efficient and reliable operation of advanced power systems. Recent advances in sensor technology have enabled some level of decision making directly at the sensor level. However, coordinating large numbers of sensors, particularly heterogeneous sensors, to achieve system level objectives such as predicting plant efficiency, reducing downtime or predicting outages requires sophisticated coordination algorithms. Indeed, a critical issue in such systems is how to ensure the interaction of a large number of heterogenous system components do not interfere with one another and lead to undesirable behavior. Objectives and Contributions: The long-term objective of this work is to provide sensor deployment, coordination and networking algorithms for large numbers of sensors to ensure the safe, reliable, and robust operation of advanced energy systems. Our two specific objectives are to: 1. Derive sensor performance metrics for heterogeneous sensor networks. 2. Demonstrate effectiveness, scalability and reconfigurability of heterogeneous sensor network in advanced power systems. The key technical contribution of this work is to push the coordination step to the design of the objective functions of the sensors, allowing networks of heterogeneous sensors to be controlled. By ensuring that the control and coordination is not specific to particular sensor hardware, this approach enables the design and operation of large heterogeneous sensor networks. In addition to the coordination coordination mechanism, this approach allows the system to be reconfigured in response to changing needs (e.g., sudden external events requiring new responses) or changing sensor network characteristics (e.g., sudden changes to plant condition). Impact: The impact of this work extends to a large class of problems relevant to the National Energy Technology Laboratory including sensor placement, heterogeneous sensor

  1. Toddlers actively reorganize their whole body coordination to maintain walking stability while carrying an object.

    Science.gov (United States)

    Hsu, Wen-Hao; Miranda, Daniel L; Chistolini, Trevor L; Goldfield, Eugene C

    2016-10-01

    Balanced walking involves freely swinging the limbs like pendula. However, children immediately begin to carry objects as soon as they can walk. One possibility for this early skill development is that whole body coordination during walking may be re-organized into loosely coupled collections of body parts, allowing children to use their arms to perform one function, while the legs perform another. Therefore, this study examines: 1) how carrying an object affects the coordination of the arms and legs during walking, and 2) if carrying an object influences stride length and width. Ten healthy toddlers with 3-12 months of walking experience were recruited to walk barefoot while carrying or not carrying a small toy. Stride length, width, speed, and continuous relative phase (CRP) of the hips and of the shoulders were compared between carrying conditions. While both arms and legs demonstrated destabilization and stabilization throughout the gait cycle, the arms showed a reduction in intra-subject coordination variability in response to carrying an object. Carrying an object may modify the function of the arms from swinging for balance to maintaining hold of an object. The observed period-dependent changes of the inter-limb coordination of the hips and of the shoulders also support this interpretation. Overall, these findings support the view that whole-body coordination patterns may become partitioned in particular ways as a function of task requirements.

  2. Optimizing Vibrational Coordinates To Modulate Intermode Coupling.

    Science.gov (United States)

    Zimmerman, Paul M; Smereka, Peter

    2016-04-12

    The choice of coordinate system strongly affects the convergence properties of vibrational structure computations. Two methods for efficient generation of improved vibrational coordinates are presented and justified by analysis of a model anharmonic two-mode Hessian and numerical computations on polyatomic molecules. To produce optimal coordinates, metrics which quantify off-diagonal couplings over a grid of Hessian matrices are minimized through unitary rotations of the vibrational basis. The first proposed metric minimizes the total squared off-diagonal coupling, and the second minimizes the total squared change in off-diagonal coupling. In this procedure certain anharmonic modes tend to localize, for example X-H stretches. The proposed methods do not rely on prior fitting of the potential energy, vibrational structure computations, or localization metrics, so they are unique from previous vibrational coordinate generation algorithms and are generally applicable to polyatomic molecules. Fitting the potential to the approximate n-mode representation in the optimized bases for all-trans polyenes shows that off-diagonal anharmonic couplings are substantially reduced by the new choices of coordinate system. Convergence of vibrational energies is examined in detail for ethylene, and it is shown that coupling-optimized modes converge in vibrational configuration interaction computations to within 1 cm(-1) using only 3-mode couplings, where normal modes require 4-mode couplings for convergence. Comparison of the vibrational configuration interaction convergence with respect to excitation level for the two proposed metrics shows that minimization of the total off-diagonal coupling is most effective for low-cost vibrational structure computations.

  3. Cognitive process-based subtypes of developmental coordination disorder (DCD).

    Science.gov (United States)

    Asonitou, Katerina; Koutsouki, Dimitra

    2016-06-01

    The purpose of the study was to identify the cognitive subtypes demonstrated by children with developmental coordination disorder (DCD) using the Planning-Attention-Simultaneous-Successive Processing (PASS) theory and the Cognitive Assessment System (D-N CAS). Participants were 108 children aged 5- and 6-years old, 54 with DCD and 54 without DCD, all attending typical kindergartens. They were examined on 31 cognitive-motor variables. Hierarchical-agglomerative and iterative partitioning cluster analyses including 9 motor and 7 cognitive variables revealed the following six subtypes: o C1 = children at risk (having considerable difficulty with jumping and minor difficulty with manual dexterity and simultaneous coding); o C2 = children on the mean (all cognitive-motor scores close to the mean); o C3 = free from cognitive-motor problems (all scores above average); o C4 = manual dexterity, planning and simultaneous coding difficulties; o C5 = manual dexterity, dynamic balance, and planning difficulties; o C6 = generalized cognitive-motor dysfunction (all scores considerably below average). It is well known that DCD is a heterogeneous condition. However, whenever cognitive processes were lower than average, cognitive-motor relationship was evident in subgroups C1, C4, C5 and C6. Early identification of task-specific cognitive-motor difficulties may be essential for early educational intervention practices in order to anticipate and improve learning, academic and performing difficulties.

  4. 点刺拔罐配合氦氖激光联合药物治疗早期带状疱疹的临床观察%Venesection Ventouse Coordinated with Helium-neon Laser Combined with Drugs Treat Early Herpes Zoster

    Institute of Scientific and Technical Information of China (English)

    马荣; 陈宏

    2015-01-01

    Objective]Observe the clinical effect of early herpes zoster which were treated by venesection ventouse combined with helium-neon laser and drugs. [Methods]The control group 32 cases used Famciclovir Tablet,transfer factor capsules,mecobalamin and acyclovir cream-drug for external use. While the experimental group 32 cases used Famciclovir Tablet,transfer factor capsules,mecobalamin and acyclovir cream-drug for external use. While the experimental group besides taking above-medicine, were treated with venesection ventouse and helium-neon laser at the pathological change. [Results]The control group used to cure for an average of 13 ±2.5 days. The experimental group used to cure for an average of 9.6 ±2.4 days. There were significant differences(P<0.05). [Conclusion] Early herpes zoster treated by venesection ventouse combined with helium-neon laser and drugs, can significantly shorten the duration of symptoms, alleviate suffering, and has good clinical efficacy.%[目的]观察点刺拔罐配合氦氖激光联合药物治疗早期带状疱疹的临床疗效。[方法]选取天津市长征医院2013年5月至2013年10月皮肤科门诊就诊的早期带状疱疹患者64例,按其就诊的先后顺序随机分为实验组32例和对照组32例,对照组给予口服药泛昔洛韦片、转移因子胶囊、甲钴胺片及外用药阿昔洛韦软膏;实验组32例,在对照组治疗基础上再施以点刺拔罐配合氦氖激光辅助治疗。运用统计学分析两组患者的平均治愈时间。[结果]对照组达到治愈所用的平均时间为13±2.5天,实验组达到治愈所用的平均时间为9.6±2.4天,实验组优于对照组,差异有统计学意义(P<0.05)。[结论]运用点刺拔罐配合氦氖激光联合药物治疗早期带状疱疹可以明显缩短病程、减轻病痛,有较好的临床疗效。

  5. Transition Metal Complexes Coordinated by Water Soluble Phosphane Ligands: How Cyclodextrins Can Alter the Coordination Sphere?

    Directory of Open Access Journals (Sweden)

    Michel Ferreira

    2017-01-01

    Full Text Available The behaviour of platinum(II and palladium(0 complexes coordinated by various hydrosoluble monodentate phosphane ligands has been investigated by 31P{1H} NMR spectroscopy in the presence of randomly methylated β-cyclodextrin (RAME-β-CD. This molecular receptor can have no impact on the organometallic complexes, induce the formation of phosphane low-coordinated complexes or form coordination second sphere species. These three behaviours are under thermodynamic control and are governed not only by the affinity of RAME-β-CD for the phosphane but also by the phosphane stereoelectronic properties. When observed, the low-coordinated complexes may be formed either via a preliminary decoordination of the phosphane followed by a complexation of the free ligand by the CD or via the generation of organometallic species complexed by CD which then lead to expulsion of ligands to decrease their internal steric hindrance.

  6. Coordinate System And Coordinate Transformations Based On Wave Nature Of Light

    CERN Document Server

    Yagan, M F

    2006-01-01

    The Classical Coordinate System is geometrical by nature with time being an external variable. Constructing a classical coordinate system employs a point-like signal with infinite speed. In Special Relativity Theory the speed is limited but the signal is a point-like particle (photon). If the oscillatory nature of light is considered, an event in absolute space is to be characterized by three coordinates namely, distance, time and phase. The Galilean transformation equations for space and time coordinates should be complemented by a third equation that accounts for the phase transformation. Wave equation remains invariant under such transformation and kinematical equivalence of inertial reference frames is conserved. Lorentz transforms apply to wave length and wave period of the exchanged light signal in a dynamic set-up.

  7. Separation of variables in an asymmetric cyclidic coordinate system

    Science.gov (United States)

    Cohl, H. S.; Volkmer, H.

    2013-06-01

    A global analysis is presented of solutions for Laplace's equation on three-dimensional Euclidean space in one of the most general orthogonal asymmetric confocal cyclidic coordinate systems which admit solutions through separation of variables. We refer to this coordinate system as five-cyclide coordinates since the coordinate surfaces are given by two cyclides of genus zero which represent inversions of each other with respect to the unit sphere, a cyclide of genus one, and two disconnected cyclides of genus zero. This coordinate system is obtained by stereographic projection of sphero-conal coordinates on four-dimensional Euclidean space. The harmonics in this coordinate system are given by products of solutions of second-order Fuchsian ordinary differential equations with five elementary singularities. The Dirichlet problem for the global harmonics in this coordinate system is solved using multiparameter spectral theory in the regions bounded by the asymmetric confocal cyclidic coordinate surfaces.

  8. Coordinated planning for science in communist europe.

    Science.gov (United States)

    Jordan, L F

    1967-02-17

    The Council is not engaged in the supranational formulation of policy and planning on scientific research and technology, but has made considerable progress in coordinating research policies and plans on a limited number of scientific and technical problems of priority interest and of common concern to all members. The establishment of national science-planning institutions in CEMA countries and the adoption of a uniform approach to the formulation of national science policies and plans must be considered basic procedures for achieving international coordination of their efforts. The creation of organizational units within CEMA to deal specifically with the coordination of science policies and plans represents a strengthening of the institutional framework that is necessary for coordination of an internationally cooperative effort in research and technology. Moreover, CEMA's 1-year plan for science and technology has probably been of considerable value as a pilot project for the formulation of the research plan for 1966-70. The delineation of a limited number of important scientific and technical problems of common interest to the members, and the allocation of research projects to a country having the highest capability to conduct them, hold considerable promise for financial savings and for improved utilization of the limited scientific manpower and research facilities of the CEMA countries. While all these measures are significant in CEMA's attempt to improve coordination of science policy and planning, only time will enable true assessment of their effectiveness. The Council's scheme for the specialization of labor in research and technology has met and will undoubtedly continue to meet, considerable opposition by various segments of the scientific communities because of deep-rooted and long-standing national prejudices, and reluctance of vested interests to give up research activities in which they are interested and to which their professional futures are

  9. A Note on Natural Coordinates and Frenet Frames

    Institute of Scientific and Technical Information of China (English)

    ZHOU Xiaozhou; ZHU Keqin

    2007-01-01

    This paper discusses the relationship between natural coordinates in fluid mechanics and orthogonal curvilinear coordinates. Since orthogonal curvilinear coordinates have some excellent mathematical properties, natural coordinates can be applied more widely if they can be transformed to orthogonal curvilinear coordinates. Frenet formulas which describe the differential properties of natural coordinates were compared with the derivative formulas of orthogonal curvilinear coordinates to show that natural coordinates are not generally orthogonal curvilinear coordinates. A method was introduced to transform natural coordinates into orthogonal curvilinear coordinates by rotating the normal planes of the natural coordinates about the streamlines. The transformation is true as long as the natural coordinates satisfy several equations. Vorticity decomposition in the natural coordinates is used to show that these conditional equations are satisfied only if the streamlines are perpendicular to the vortexlines on every given point in the flow field. These equations apply in both planar flows and axisymmetric flows without a circumferential velocity component, but do not apply in some 3-D flows such as Beltrami flow.

  10. Head-Torso-Hand Coordination in Children with and without Developmental Coordination Disorder

    Science.gov (United States)

    Elders, Vera; Sheehan, Sinead; Wilson, Andrew D.; Levesley, Martin; Bhakta, Bipin; Mon-Williams, Mark

    2010-01-01

    Aim: This study investigated the nature of coordination and control problems in children with developmental coordination disorder (DCD). Method: Seven adults (two males, five females, age range 20-28y; mean 23y, SD 2y 8mo) and eight children with DCD (six males, two females, age range 7-9y; mean 8y, SD 8mo), and 10 without DCD (seven males, three…

  11. Appendage modal coordinate truncation criteria in hybrid coordinate dynamic analysis. [for spacecraft attitude control

    Science.gov (United States)

    Likins, P.; Ohkami, Y.; Wong, C.

    1976-01-01

    The paper examines the validity of the assumption that certain appendage-distributed (modal) coordinates can be truncated from a system model without unacceptable degradation of fidelity in hybrid coordinate dynamic analysis for attitude control of spacecraft with flexible appendages. Alternative truncation criteria are proposed and their interrelationships defined. Particular attention is given to truncation criteria based on eigenvalues, eigenvectors, and controllability and observability. No definitive resolution of the problem is advanced, and exhaustive study is required to obtain ultimate truncation criteria.

  12. Coordinated formation control of multiple nonlinear systems

    Institute of Scientific and Technical Information of China (English)

    Wei KANG; Ning XI; Jindong TAN; Yiwen ZHAO; Yuechao WANG

    2005-01-01

    A general method of controller design is developed for the purpose of formation keeping and reconfiguration of nonlinear systems with multiple subsystems,such as the formation of multiple aircraft,ground vehicles,or robot arms.The model consists of multiple nonlinear systems.Controllers are designed to keep the subsystems in a required formation and to coordinate the subsystems in the presence of environmental changes.A step-by-step algorithm of controller design is developed.Sufficient conditions for the stability of formation tracking are proved.Simulations and experiments are conducted to demonstrate some useful coordination strategies such as movement with a leader,simultaneous movement,series connection of formations,and human-machine interaction.

  13. The coordination of care across borders

    DEFF Research Database (Denmark)

    Kierkegaard, Patrick

    -savings, improved quality of care, avoidance of unnecessary tests, improved work efficiency, reduced waiting times and improvement in the overall efficiency of the healthcare system. Although benefits exists, healthcare organizations have experienced difficulties attaining them and overall adoption of e...... with implementing a new system, and uncertainty that the technology may actually reduce overall costs. The coordination of care across boundaries presents a plethora of issues that need to be tackled from a policy, legal, practical research perspective. This thesis attempts to address pressing issues...... with a particular focus on the implications health information exchange for the purposes of coordinating care will have on both the patient and healthcare professionals on three levels: international, national and institutional level. The findings of this thesis imply that in order for cross-border health...

  14. Intercell Interference Coordination through Limited Feedback

    Directory of Open Access Journals (Sweden)

    Lingjia Liu

    2010-01-01

    Full Text Available We consider the applications of multicell transmission schemes to the downlink of future wireless communication networks. A multicell multiple-input multiple output-(MIMOs based scheme with limited coordination among neighboring base stations (BSs is proposed to effectively combat the intercell interference by taking advantage of the degreesoffreedom in the spatial domain. In this scheme, mobile users are required to feedback channel-related information to both serving base station and interfering base station. Furthermore, a chordal distance-based compression scheme is introduced to reduce the feedback overhead. The performance of the proposed scheme is investigated through theoretical analysis as well as system level simulations. Both results suggest that the so-called “intercell interference coordination through limited feedback” scheme is a very good candidate for improving the cell-edge user throughput as well as the average cell throughput of the future wireless communication networks.

  15. Identifiability of linear systems in physical coordinates

    Science.gov (United States)

    Su, Tzu-Jeng; Juang, Jer-Nan

    1992-01-01

    Identifiability of linear, time-invariant systems in physical coordinates is discussed. It is shown that identification of the system matrix in physical coordinates can be accomplished by determining a transformation matrix that relates the physical locations of actuators and sensors to the test-data-derived input and output matrices. For systems with symmetric matrices, the solution of a constrained optimization problem is used to characterize all the possible solutions of the transformation matrix. Conditions for the existence of a unique transformation matrix are established easily from the explicit form of the solutions. For systems with limited inputs and outputs, the question about which part of the system can be uniquely identified is also answered. A simple mass-spring system is used to verify the conclusions of this study.

  16. Non covalent assembly of coordination superstructures

    CERN Document Server

    Khlobystov, A N

    2002-01-01

    The main topic of this work is the design of discrete and polymeric multi-component coordination structures using non-covalent interactions between organic and inorganic molecular components. All of the structures described herein are based on transition metal cations and N-donor heterocyclic bis-exodentate ligands with different geometries and various spacer functionalities. The predominant method used for the structural characterisation of the complexes was single crystal X-ray crystallography. X-ray powder diffraction, IR and NMR spectroscopies and TEM and AFM imaging were used to characterise the bulk products from the reactions. Chapter 1 is a comparative review of non-covalent interactions relevant to coordination superstructures and covers the latest developments in the area of crystal engineering and supramolecular chemistry. The nature, geometry and relative energy of the non-covalent interactions are considered in detail in order to reveal their influence on the structure and properties of complexes...

  17. Robust Parameter Coordination for Multidisciplinary Design

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper introduced a robust parameter coordination method to analyze parameter uncertainties so as to predict conflicts and coordinate parameters in multidisciplinary design. The proposed method is based on constraints network, which gives a formulated model to analyze the coupling effects between design variables and product specifications. In this model, interval boxes are adopted to describe the uncertainty of design parameters quantitatively to enhance the design robustness. To solve this constraint network model, a general consistent algorithm framework is designed and implemented with interval arithmetic and the genetic algorithm, which can deal with both algebraic and ordinary differential equations. With the help of this method, designers could infer the consistent solution space from the given specifications. A case study involving the design of a bogie dumping system demonstrates the usefulness of this approach.

  18. Update of technical coordinating committee activities

    Energy Technology Data Exchange (ETDEWEB)

    Alvarado, R.A.

    1995-12-31

    The Technical Coordinating Committee has its origins in the earliest days of implementing the Low-Level Radioactive Waste Policy Act. Between 1982 and 1985, individuals in several of the states felt that coordination among the states would be beneficial to all by affording states a cost-effective method for sharing ideas, discussing alternatives, and presenting solutions to common problems. At the current time, the committee comprises members from each of the sited states. Various compacts, federal agencies, and industry groups participate in committee activities. The Low-Level Management Program provides support for the committee through the provision of logistical support and limited manpower allocation. Activities of the committee have recently focused on waste treatment and minimization technologies. The committee also has worked diligently to see the review of the 3RSTAT computer code completed. The committee has taken a position on various regulatory proposals the past year. The committee expects to continue its work until new sites are brought online.

  19. VIRTUE ETHICS - NEW COORDINATES FOR ECONOMIC DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    PUP ANCA

    2010-12-01

    Full Text Available Operating with business ethic we meet, some ethical systems, some of them developed in Antiquity, that still have a great influence upon economics development. One of these is the ethics of virtue. The aim of this paper work is to focus upon the one ethical system virtue ethics and to illustrate his influence in economical field, offering a new coordination in this direction. We understand the importance of the human character for a successful leadership and management. Recent ethical dilemmas illustrate us how a vicious character has an influence not only to the possessor of that type of character but also to the entire community where he develop his activities. For a comprehensive understanding I expose a briefly review on virtue ethics as it was developed by Plato and Aristotle, ant its new coordination and influence upon our contemporaneous economy, illustrated by some examples.

  20. Learning From Movie-Sets Coordination

    DEFF Research Database (Denmark)

    Egebjerg, Christin

    A comparative study of large, professional movie sets and construction sites revealed that conditions for movie production were far more complex and unpredictable, with sudden surprises, changing facilities and often hundreds of people from independent professional groups to be coordinated from...... industries live with the reality of obstacles occurring on the ‘critical path’ and the process becoming not as fast as anticipated. So there is a need for a map of alternative ‘short cuts’ to get back on track. Usually this work is managed inside the head of a professional construction manager, but even...... to that used on movie sets for detailed scheduling, coordinating and micro-managing construction processes. The current working name for this digital tool is “Short Cut”, and it is seen as a future supplement to common scheduling tools with application for project parts that are particular sensitive...

  1. PDGFRaa Signaling Is Regulated through the Primary Cilium in Fibroblasts

    DEFF Research Database (Denmark)

    Schneider, Linda; Clement, Christian Alexandro; Teilmann, S.C.

    2005-01-01

    or mislocation of ciliary signal components affects human pathologies, such as polycystic kidney disease [ 7 ] and disorders associated with Bardet-Biedl syndrome [ 8 ]. Primary cilia are essential for hedgehog ligand-induced signaling cascade regulating growth and patterning [ [9] and [10] ]. Here, we show...

  2. High-aspect ratio magnetic nanocomposite polymer cilium

    Science.gov (United States)

    Rahbar, M.; Tseng, H. Y.; Gray, B. L.

    2014-03-01

    This paper presents a new fabrication technique to achieve ultra high-aspect ratio artificial cilia micro-patterned from flexible highly magnetic rare earth nanoparticle-doped polymers. We have developed a simple, inexpensive and scalable fabrication method to create cilia structures that can be actuated by miniature electromagnets, that are suitable to be used for lab-on-a chip (LOC) and micro-total-analysis-system (μ-TAS) applications such as mixers and flow-control elements. The magnetic cilia are fabricated and magnetically polarized directly in microfluidic channels or reaction chambers, allowing for easy integration with complex microfluidic systems. These cilia structures can be combined on a single chip with other microfluidic components employing the same permanently magnetic nano-composite polymer (MNCP), such as valves or pumps. Rare earth permanent magnetic powder, (Nd0.7Ce0.3)10.5Fe83.9B5.6, is used to dope polydimethylsiloxane (PDMS), resulting in a highly flexible M-NCP of much higher magnetization and remanence [1] than ferromagnetic polymers typically employed in magnetic microfluidics. Sacrificial poly(ethylene-glycol) (PEG) is used to mold the highly magnetic polymer into ultra high-aspect ratio artificial cilia. Cilia structures with aspect ratio exceeding 8:0.13 can be easily fabricated using this technique and are actuated using miniature electromagnets to achieve a high range of motion/vibration.

  3. Determination of Chinese mobile SLR sites' coordinates

    Institute of Scientific and Technical Information of China (English)

    FENG Chugang; CAI Wusan; ZHU Yuanlan; YANG Fumin

    2003-01-01

    The geocentric coordinates of three mobile sites including Fangshan inBeijing, Urumqi in the Xinjiang Uygur Autonomous Region and Lhasa in Tibet are determined in the ITRF2000 frame by means of both the global SLR data and the mobile (SLR) data obtained by a mobile satellite laser ranging (SLR) apparatus from Aug. 2000 to Dec. 2001. The results showed that the geometrical performance ofChinese SLR network has been significantly improved.

  4. Interference Coordination for Dense Wireless Networks

    DEFF Research Database (Denmark)

    Soret, Beatriz; Pedersen, Klaus I.; Jørgensen, Niels T.K.;

    2015-01-01

    The promise of ubiquitous and super-fast connectivity for the upcoming years will be in large part fulfilled by the addition of base stations and spectral aggregation. The resulting very dense networks (DenseNets) will face a number of technical challenges. Among others, the interference emerges...... simply react to an identified interference problem. As an example, we propose two algorithms to apply time domain and frequency domain small cell interference coordination in a DenseNet....

  5. Topochemical control in desolvation of coordination polymers

    OpenAIRE

    Matteo Lusi

    2015-01-01

    Reactions in the solid state are at the core of crystal engineering as they can result in new crystalline phases that are not always accessible by traditional solution methods. The work of Brammer and co-workers [Wright et al. (2015), IUCrJ, 2, 188–197] represents a clear example of this potential as applied to the synthesis of a silver–phenazine coordination polymer.

  6. Coordinating, Scheduling, Processing and Analyzing IYA09

    Science.gov (United States)

    Gipson, John; Behrend, Dirk; Gordon, David; Himwich, Ed; MacMillan, Dan; Titus, Mike; Corey, Brian

    2010-01-01

    The IVS scheduled a special astrometric VLBI session for the International Year of Astronomy 2009 (IYA09) commemorating 400 years of optical astronomy and 40 years of VLBI. The IYA09 session is the most ambitious geodetic session to date in terms of network size, number of sources, and number of observations. We describe the process of designing, coordinating, scheduling, pre-session station checkout, correlating, and analyzing this session.

  7. Investigating Silver Coordination to Mixed Chalcogen Ligands

    Directory of Open Access Journals (Sweden)

    J. Derek Woollins

    2012-11-01

    Full Text Available Six silver(I coordination complexes have been prepared and structurally characterised. Mixed chalcogen-donor acenaphthene ligands L1–L3 [Acenap(EPh(E'Ph] (Acenap = acenaphthene-5,6-diyl; E/E' = S, Se, Te were independently treated with silver(I salts (AgBF4/AgOTf. In order to keep the number of variables to a minimum, all reactions were carried out using a 1:1 ratio of Ag/L and run in dichloromethane. The nature of the donor atoms, the coordinating ability of the respective counter-anion and the type of solvent used in recrystallisation, all affect the structural architecture of the final silver(I complex, generating monomeric, silver(I complexes {[AgBF4(L2] (1 L = L1; 2 L = L2; 3 L = L3, [AgOTf(L3] (4 L = L1; 5 L = L3, [AgBF4(L3] (2a L = L1; 3a L = L3} and a 1D polymeric chain {[AgOTf(L3]n 6}. The organic acenaphthene ligands L1-L3 adopt a number of ligation modes (bis-monodentate μ2-η2-bridging, quasi-chelating combining monodentate and η6-E(phenyl-Ag(I and classical monodentate coordination with the central silver atom at the centre of a tetrahedral or trigonal planar coordination geometry in each case. The importance of weak interactions in the formation of metal-organic structures is also highlighted by the number of short non-covalent contacts present within each complex.

  8. Coordination Supramolecular Chemistry and Crystal Engineering

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    @@ Consisting of five young researchers from the Sun Yat-Sen University in Guangzhou, the research group has been devoted to the interdisciplinary research in chemistry, materials science and chemical biology.To be specific, the focus of their research is to develop new functional molecular materials through rational molecular design and crystal engineering, including porous materials (or porous coordination polymers), electronic and magnetic molecular materials, bio-mimic materials, and supramolecular catalytical materials.

  9. Interstate Solar Coordination Council. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Block, David L.

    1981-02-15

    The ISCC program accomplishments and future plans are reported as follows: overall activities; development of a national standards and certification program for solar collectors; development of a national organization for operating the collector certification program; review of applicability and use of solar collector rating procedures; development of a program for evaluation/testing/certification of solar systems; development of ISCC as a formal and independent organization; development of sizing and installation manual; and coordination efforts with other solar groups. (MHR)

  10. Promoting coordination in Norwegian health care

    Directory of Open Access Journals (Sweden)

    Tor I. Romøren

    2011-10-01

    Full Text Available   Introduction: The Norwegian health care system is well organized within its two main sectors - primary health and long term care on the one hand, and hospitals and specialist services on the other. However, the relation between them lacks mediating structures.Policy practice: Enhancing coordination between primary and secondary health care has been central in Norwegian health care policy the last decade. In 2003 a committee was appointed to identify coordination problems and proposed a lot of practical and organisational recommendations. It relied on an approach challenging primary and secondary health care in shared geographical regions to take action. However, these proposals were not implemented. In 2008 a new Minister of Health and Care worked out plans under the key term "Coordination Reform". These reform plans superseded and expanded the previous policy initiatives concerning cooperation, but represented also a shift in focus to a regulative and centralised strategy, including new health legislation, structural reforms and use of economic incentives that are now about to be implemented.Discussion: The article analyses the perspectives and proposals of the previous and the recent reform initiatives in Norway and discusses them in relation to integrated care measures implemented in Denmark and Sweden.

  11. Promoting coordination in Norwegian health care

    Directory of Open Access Journals (Sweden)

    Tor I. Romøren

    2011-10-01

    Full Text Available   Introduction: The Norwegian health care system is well organized within its two main sectors - primary health and long term care on the one hand, and hospitals and specialist services on the other. However, the relation between them lacks mediating structures. Policy practice: Enhancing coordination between primary and secondary health care has been central in Norwegian health care policy the last decade. In 2003 a committee was appointed to identify coordination problems and proposed a lot of practical and organisational recommendations. It relied on an approach challenging primary and secondary health care in shared geographical regions to take action. However, these proposals were not implemented. In 2008 a new Minister of Health and Care worked out plans under the key term "Coordination Reform". These reform plans superseded and expanded the previous policy initiatives concerning cooperation, but represented also a shift in focus to a regulative and centralised strategy, including new health legislation, structural reforms and use of economic incentives that are now about to be implemented. Discussion: The article analyses the perspectives and proposals of the previous and the recent reform initiatives in Norway and discusses them in relation to integrated care measures implemented in Denmark and Sweden.

  12. Nanometrization of Lanthanide-Based Coordination Polymers.

    Science.gov (United States)

    Neaime, Chrystelle; Daiguebonne, Carole; Calvez, Guillaume; Freslon, Stéphane; Bernot, Kevin; Grasset, Fabien; Cordier, Stéphane; Guillou, Olivier

    2015-11-23

    Heteronuclear lanthanide-based coordination polymers are microcrystalline powders, the luminescence properties of which can be precisely tuned by judicious choice of the rare-earth ions. In this study, we demonstrate that such materials can also be obtained as stable solutions of nanoparticles in non-toxic polyols. Bulk powders of the formula [Ln2-2x Ln'2x (bdc)3 ⋅4 H2 O]∞ (where H2 bdc denotes 1,4-benzene-dicarboxylic acid, 0≤x≤1, and Ln and Ln' denote lanthanide ions of the series La to Tm plus Y) afford nanoparticles that have been characterized by dynamic light-scattering (DLS) and transmission electron microscopy (TEM) measurements. Their luminescence properties are similar to those of the bulk materials. Stabilities versus time and versus dilution with another solvent have been studied. This study has revealed that it is possible to tune the size of the nanoparticles. This process offers a reliable means of synthesizing suspensions of nanoparticles with tunable luminescence properties and tunable size distributions in a green solvent (glycerol). The process is also extendable to other coordination polymers and other solvents (ethylene glycol, for example). It constitutes a new route for the facile solubilization of lanthanide-based coordination polymers.

  13. Adaptive group coordination and role differentiation.

    Directory of Open Access Journals (Sweden)

    Michael E Roberts

    Full Text Available Many real world situations (potluck dinners, academic departments, sports teams, corporate divisions, committees, seminar classes, etc. involve actors adjusting their contributions in order to achieve a mutually satisfactory group goal, a win-win result. However, the majority of human group research has involved situations where groups perform poorly because task constraints promote either individual maximization behavior or diffusion of responsibility, and even successful tasks generally involve the propagation of one correct solution through a group. Here we introduce a group task that requires complementary actions among participants in order to reach a shared goal. Without communication, group members submit numbers in an attempt to collectively sum to a randomly selected target number. After receiving group feedback, members adjust their submitted numbers until the target number is reached. For all groups, performance improves with task experience, and group reactivity decreases over rounds. Our empirical results provide evidence for adaptive coordination in human groups, and as the coordination costs increase with group size, large groups adapt through spontaneous role differentiation and self-consistency among members. We suggest several agent-based models with different rules for agent reactions, and we show that the empirical results are best fit by a flexible, adaptive agent strategy in which agents decrease their reactions when the group feedback changes. The task offers a simple experimental platform for studying the general problem of group coordination while maximizing group returns, and we distinguish the task from several games in behavioral game theory.

  14. Interference Alignment with Partially Coordinated Transmit Precoding

    CERN Document Server

    Yousafzai, Aimal Khan

    2011-01-01

    In this paper, we introduce an efficient interference alignment (IA) algorithm exploiting partially coordinated transmit precoding to improve the number of concurrent interference-free transmissions, i.e., the multiplexing gain, in multicell downlink. The proposed coordination model is such that each base-station simultaneously transmits to two users and each user is served by two base-stations. First, we show in a K-user system operating at the information theoretic upper bound of degrees of freedom (DOF), the generic IA is proper when $K \\leq 3$, whereas the proposed partially coordinated IA is proper when $K \\leq 5$. Then, we derive a non-iterative, i.e., one shot, IA algorithm for the proposed scheme when $K \\leq 5$. We show that for a given latency, the backhaul data rate requirement of the proposed method grows linearly with K. Monte-Carlo simulation results show that the proposed one-shot algorithm offers higher system throughput than the iterative IA at practical SNR levels.

  15. Bimanual motor coordination controlled by cooperative interactions in intrinsic and extrinsic coordinates.

    Science.gov (United States)

    Sakurada, Takeshi; Ito, Koji; Gomi, Hiroaki

    2016-01-01

    Although strong motor coordination in intrinsic muscle coordinates has frequently been reported for bimanual movements, coordination in extrinsic visual coordinates is also crucial in various bimanual tasks. To explore the bimanual coordination mechanisms in terms of the frame of reference, here we characterized implicit bilateral interactions in visuomotor tasks. Visual perturbations (finger-cursor gain change) were applied while participants performed a rhythmic tracking task with both index fingers under an in-phase or anti-phase relationship in extrinsic coordinates. When they corrected the right finger's amplitude, the left finger's amplitude unintentionally also changed [motor interference (MI)], despite the instruction to keep its amplitude constant. Notably, we observed two specificities: one was large MI and low relative-phase variability (PV) under the intrinsic in-phase condition, and the other was large MI and high PV under the extrinsic in-phase condition. Additionally, using a multiple-interaction model, we successfully decomposed MI into intrinsic components caused by motor correction and extrinsic components caused by visual-cursor mismatch of the right finger's movements. This analysis revealed that the central nervous system facilitates MI by combining intrinsic and extrinsic components in the condition with in-phases in both intrinsic and extrinsic coordinates, and that under-additivity of the effects is explained by the brain's preference for the intrinsic interaction over extrinsic interaction. In contrast, the PV was significantly correlated with the intrinsic component, suggesting that the intrinsic interaction dominantly contributed to bimanual movement stabilization. The inconsistent features of MI and PV suggest that the central nervous system regulates multiple levels of bilateral interactions for various bimanual tasks.

  16. International Coordination of Exploring and Using Lunar Polar Volatiles

    Science.gov (United States)

    Gruener, J. E.; Suzuki, N. H.; Carpenter, J. D.

    2016-11-01

    This abstract discusses the efforts of an International Space Exploration Coordination Group (ISECG) study team to coordinate the worldwide exploration of lunar polar volatiles. This effort includes the development of a website and conducting virtual workshops.

  17. Key drivers for informal project coordination among sub-contractors

    DEFF Research Database (Denmark)

    Aagaard, Annabeth; Eskerod, Pernille; Madsen, Erik Skov

    2015-01-01

    Despite good planning, projects need continuous coordination among the participants concerning scope of work, pace, and timing to be accomplished without delays. Research shows that informal coordination of residual and unforeseen interdependencies enhances time saving and facilitates better unde...

  18. Multi-Agent Systems for Transportation Planning and Coordination

    NARCIS (Netherlands)

    J.M. Moonen (Hans)

    2009-01-01

    textabstractMany transportation problems are in fact coordination problems: problems that require communication, coordination and negotiation to be optimally solved. However, most software systems targeted at transportation have never approached it this way, and have instead concentrated on centrali

  19. 77 FR 57638 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-09-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... new measures; Formal safety assessment; Piracy and armed robbery against ships; Implementation...

  20. 75 FR 64390 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-10-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... --Formal safety assessment --Piracy and armed robbery against ships --General cargo ship...

  1. 76 FR 19176 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2011-04-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct two... safety --Piracy and armed robbery against ships --Implementation of instruments and related...

  2. 78 FR 29201 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-05-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... new measures Formal safety assessment Piracy and armed robbery against ships Implementation...

  3. Neurobiology: reconstructing the neural control of leg coordination.

    Science.gov (United States)

    Zill, Sasha N; Keller, Bridget R

    2009-05-12

    Walking is adaptable because the timing of movements of individual legs can be varied while maintaining leg coordination. Recent work in stick insects shows that leg coordination set by interactions of pattern generating circuits can be overridden by sensory feedback.

  4. Is it easy to take care of coordinating a "Children's Program of Hearing Loss"?

    Directory of Open Access Journals (Sweden)

    José Ignacio BENITO-OREJAS

    2016-03-01

    Full Text Available Introduction and objective: Hearing loss is the most prevalent sensory deficiency at birth. Even though, coordinating a program for early detection and care may seem simple tasks, they are not so when it takes responsibility for the negative impact that a delay in the identification or treatment, can cause in the linguistic and educational development of the child. With this review, we provide an overview of the commitment involved in the practice of this task. Method: We analyze functions assigned to the supervisor of a "Children's Program of Hearing Loss", which are set in the program of the Community of Castilla y León, that are a reflection of other communities and countries, because they belong to an international consensus backed by different regulatory organisms, which in Spain corresponds to the Commission for the Early Detection of Hearing Loss (CODEPEH. Results: The coordinator of a "Children's Program of Hearing Loss" should monitor the early identification of the new born with hearing impairment, ensure early diagnosis and treatment, ask for specific tests and assess the success of the intervention. This process focuses on the family as a key driver of the project. The institutional and administrative support should be at the service of this activity. Conclusions: Take over a "Children's Program of Hearing Loss" implies a global conception, which consists of establishing a preventive control of hearing health of the child, that increases the complexity of their development.

  5. THE IMPORTANCE OF COORDINATIVE ABILITIES IN ACHIEVING ATHLETIC PERFORMANCE

    OpenAIRE

    Neluta Smidu

    2014-01-01

    During the training process, the development of coordinative abilities represents a priority from the first stage of training. Coordinative abilities, as well as speed, are genetically determined; therefore the possibility of improving them is lower for athletes who do not have these innate abilities. Training coordinative abilities at the proper time is crucial in what concerns future development capacity. Developing coordinative abilities to a higher level influences learning and perfecting...

  6. Combined Method of Datum Transformation Between Different Coordinate Systems

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The similarity transformation model between different coordinate systems is not accurate enough to describe the discrepancy of them.Therefore,the coordinate transformation from the coordinate frame with poor accuracy to that with high accuracy cannot guarantee a high precision of transformation.In this paper,a combined method of similarity transformation and regressive approximating is presented.The local error accumulation and distortion are taken into consideration and the precision of coordinate system is improved by using the recommended method.

  7. Addressing some misperceptions of the joint coordinate system.

    Science.gov (United States)

    MacWilliams, Bruce A; Davis, Roy B

    2013-05-01

    The joint coordinate system convention proposed by Grood and Suntay has been widely adopted, but often misrepresented. Previous work has argued by logical explanation of the approach that the joint coordinate system is a set of Euler or Cardan angles. The current work offers both an explanation and mathematical proof that the joint coordinate system convention is equivalent to a Cardan angle sequence, thereby demonstrating the joint coordinate system angles are both sequence dependent and orthogonal.

  8. Emergence and stability of interlimb coordination patterns in children with developmental coordination disorder.

    Science.gov (United States)

    de Castro Ferracioli, Marcela; Hiraga, Cynthia Yukiko; Pellegrini, Ana Maria

    2014-02-01

    The purpose of this study was to investigate the emergence and stability of coordination patterns in children with developmental coordination disorder (DCD) when performing a rhythmic interlimb coordination task on rigid (floor) and elastic (mini-trampoline) surfaces. Twelve typically developing (TD) children and 12 children with DCD were required to clap while jumping under different conditions: in a chosen pattern - Free; when the feet touched the surface - Clapping-surface; when the body reached the maximum jumping height - Clapping-jump; and when the feet touched the surface and the body reached the maximum jumping height - Clapping-both. The results showed that the coordination pattern of children with DCD was more variable in the Free, Clapping-surface, and Clapping-jumping conditions and more variable on the mini-trampoline than on the floor under the Free condition when compared with the TD children. Clapping-jumping was more difficult to perform than Clapping-surface for both groups. These findings suggest that the children with DCD were less capable of rhythmically coordinating the jumping-clapping task because they used a type of exploratory strategy regarding the physical properties of the surfaces, whereas the TD children used a type of adaptive strategy displaying behavior that was more consistent across the tasks/environmental demands.

  9. 42 CFR 438.208 - Coordination and continuity of care.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Coordination and continuity of care. 438.208... Improvement Access Standards § 438.208 Coordination and continuity of care. (a) Basic requirement—(1) General... MCO must meet the primary care coordination, identification, assessment, and treatment...

  10. Value-driven coordination process design using physical delivery models

    NARCIS (Netherlands)

    Wieringa, R.J.; Pijpers, V.; Bodenstaff, L.; Gordijn, J.

    2008-01-01

    Current e-business technology enables the execution of increasingly complex coordination processes that link IT services of different companies. Successful design of cross-organizational coordination processes requires the mutual alignment of the coordination process with a commercial business case.

  11. Development of Interpersonal Coordination Between Peers During a Drumming Task

    NARCIS (Netherlands)

    Endedijk, Hinke M.; Ramenzoni, Veronica C. O.; Cox, Ralf F. A.; Cillessen, Antonius H. N.; Bekkering, Harold; Hunnius, Sabine

    2015-01-01

    During social interaction, the behavior of interacting partners becomes coordinated. Although interpersonal coordination is well-studied in adults, relatively little is known about its development. In this project we explored how 2-, 3-, and 4-year-old children spontaneously coordinated their drummi

  12. Development of Interpersonal Coordination between Peers during a Drumming Task

    Science.gov (United States)

    Endedijk, Hinke M.; Ramenzoni, Veronica C. O.; Cox, Ralf F. A.; Cillessen, Antonius H. N.; Bekkering, Harold; Hunnius, Sabine

    2015-01-01

    During social interaction, the behavior of interacting partners becomes coordinated. Although interpersonal coordination is well-studied in adults, relatively little is known about its development. In this project we explored how 2-, 3-, and 4-year-old children spontaneously coordinated their drumming with a peer. Results showed that all children…

  13. Direct Timing Method for Longitudinal Coordinate Determination in Straws

    OpenAIRE

    Makhankin, A. M.; Myalkovsky, V. V.; Peshekhonov, V. D.; Vasilyev, S. E.

    2013-01-01

    The considering different technics of measuring the longitudinal coordinates by the drift tubes. It is shown that the determination of the longitudinal coordinate by the direct time method provides the best longitudinal resolution. The realization of this method enables the development of coordinate detectors based on the straw with two-dimensional readout, which can be fast enough and not very complex.

  14. Attentional Loads Associated with Interlimb Interactions Underlying Rhythmic Bimanual Coordination

    Science.gov (United States)

    Ridderikhoff, Arne; Peper, C. E.; Beek, Peter J.

    2008-01-01

    Studies of rhythmic bimanual coordination under dual-task conditions revealed (1) a dependence of secondary task performance on the stability of coordinative tasks, in that secondary task performance was better during in-phase than antiphase coordination, and (2) a shift in the mean relative phasing between the limbs compared to single-task…

  15. Biangular Coordinates Redux: Discovering a New Kind of Geometry

    Science.gov (United States)

    Winkel, Brian; Naylor, Michael

    2010-01-01

    Biangular coordinates specify a point on the plane by two angles giving the intersection of two rays emanating from two fixed poles. This is a dual of Cartesian coordinates wherein a point on the plane is described by two distances. Biangular coordinates, first written about in 1803 in France, were subsequently studied in Britain at the end of the…

  16. How Do Teachers Coordinate Their Work? A Framing Approach

    Science.gov (United States)

    Dumay, Xavier

    2014-01-01

    Since the 1970s, schools have been characterized as loosely coupled systems, meaning that the teachers' work is weakly coordinated at the local level. Nonetheless, few studies have focused on the local variations of coordination modes, their sources and their nature. In this article, the process of local coordination of the teachers' work is…

  17. Impaired Visuo-Motor Sequence Learning in Developmental Coordination Disorder

    Science.gov (United States)

    Gheysen, Freja; Van Waelvelde, Hilde; Fias, Wim

    2011-01-01

    The defining feature of Developmental Coordination Disorder (DCD) is the marked impairment in the development of motor coordination (DSM-IV-TR, American Psychiatric Association, 2000). In the current study, we focused on one core aspect of motor coordination: learning to correctly sequence movements. We investigated the procedural, visuo-motor…

  18. Self-Concept of Boys with Developmental Coordination Disorder

    Science.gov (United States)

    Cocks, Neralie; Barton, Belinda; Donelly, Michelle

    2009-01-01

    Children with Developmental Coordination Disorder (DCD) experience difficulties in motor coordination. During the last decade there has been increasing interest in the psychosocial aspects of children with motor coordination difficulties. To date, the majority of studies have focused on the perceived competence and global self-worth of children…

  19. Studying the cosmological apparent horizon with quasistatic coordinates

    Indian Academy of Sciences (India)

    Rui-Yan Yu; Towe Wang

    2013-02-01

    This article aims at a natural generalization of the static coordinates to the ( + 1)-dimensional Friedmann–Lemaître–Robertson–Walker (FLRW) Universe. After demonstrating a no-go theorem, we put forward the quasistatic coordinates for the FLRW Universe. Then, the quasistatic coordinates are utilized to study the unified first law and the scalar-type perturbations on the cosmological apparent horizon.

  20. 47 CFR 25.251 - Special requirements for coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Special requirements for coordination. 25.251... SATELLITE COMMUNICATIONS Technical Standards § 25.251 Special requirements for coordination. (a) The administrative aspects of the coordination process are set forth in § 101.103 of this chapter in the case...

  1. 6 CFR 17.635 - Forms and instructions; coordination.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Forms and instructions; coordination. 17.635... Procedures § 17.635 Forms and instructions; coordination. (a) Forms and instructions. The designated agency... procedures for effectuating these Title IX regulations. (b) Supervision and coordination. The...

  2. 7 CFR 3015.304 - Federal interagency coordination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Federal interagency coordination. 3015.304 Section... of Department of Agriculture Programs and Activities § 3015.304 Federal interagency coordination. The... Federal departments and agencies in an effort to assure full coordination between such agencies and...

  3. 14 CFR 1204.1505 - Federal interagency coordination.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Federal interagency coordination. 1204.1505... Activities § 1204.1505 Federal interagency coordination. The Administrator to the extent practicable... effort to assure full coordination between such agencies and the Agency regarding programs and...

  4. 31 CFR 28.635 - Forms and instructions; coordination.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Forms and instructions; coordination... Procedures § 28.635 Forms and instructions; coordination. (a) Forms and instructions. The designated agency... procedures for effectuating these Title IX regulations. (b) Supervision and coordination. The...

  5. 48 CFR 852.236-80 - Subcontracts and work coordination.

    Science.gov (United States)

    2010-10-01

    ... coordination. 852.236-80 Section 852.236-80 Federal Acquisition Regulations System DEPARTMENT OF VETERANS....236-80 Subcontracts and work coordination. As prescribed in 836.574, insert the following clause: Subcontracts and Work Coordination (APR 1984) (a) Nothing contained in this contract shall be construed...

  6. 18 CFR 740.11 - Federal/State coordination.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Federal/State coordination. 740.11 Section 740.11 Conservation of Power and Water Resources WATER RESOURCES COUNCIL STATE WATER MANAGEMENT PLANNING PROGRAM § 740.11 Federal/State coordination. The Council will coordinate...

  7. 48 CFR 836.574 - Subcontracts and work coordination.

    Science.gov (United States)

    2010-10-01

    ... coordination. 836.574 Section 836.574 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Subcontracts and work coordination. The contracting officer shall insert the clause at 852.236-80, Subcontracts and work coordination, in solicitations and contracts for construction expected to exceed the...

  8. 30 CFR 281.13 - Joint State/Federal coordination.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Joint State/Federal coordination. 281.13....13 Joint State/Federal coordination. (a) The Secretary may invite the adjacent State Governor(s) to... a State/Federal task force or some other joint planning or coordination arrangement when...

  9. 36 CFR 1211.635 - Forms and instructions; coordination.

    Science.gov (United States)

    2010-07-01

    ...; coordination. 1211.635 Section 1211.635 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS... FEDERAL FINANCIAL ASSISTANCE Procedures § 1211.635 Forms and instructions; coordination. (a) Forms and...) Supervision and coordination. The Archivist or his designee may from time to time assign to officials of...

  10. 41 CFR 101-6.215-3 - Supervision and coordination.

    Science.gov (United States)

    2010-07-01

    ... coordination. 101-6.215-3 Section 101-6.215-3 Public Contracts and Property Management Federal Property...-Nondiscrimination in Programs Receiving Federal Financial Assistance § 101-6.215-3 Supervision and coordination. The... provided in § 101-6.213), including the achievement of effective coordination and maximum uniformity...

  11. 29 CFR 34.12 - Delegation and coordination.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Delegation and coordination. 34.12 Section 34.12 Labor... Delegation and coordination. (a) The Secretary may from time to time assign to officials of other departments... effective coordination and maximum uniformity within the Department and within the executive branch of...

  12. Ab initio coordination chemistry for nickel chelation motifs.

    Science.gov (United States)

    Sudan, R Jesu Jaya; Kumari, J Lesitha Jeeva; Sudandiradoss, C

    2015-01-01

    Chelation therapy is one of the most appreciated methods in the treatment of metal induced disease predisposition. Coordination chemistry provides a way to understand metal association in biological structures. In this work we have implemented coordination chemistry to study nickel coordination due to its high impact in industrial usage and thereby health consequences. This paper reports the analysis of nickel coordination from a large dataset of nickel bound structures and sequences. Coordination patterns predicted from the structures are reported in terms of donors, chelate length, coordination number, chelate geometry, structural fold and architecture. The analysis revealed histidine as the most favored residue in nickel coordination. The most common chelates identified were histidine based namely HHH, HDH, HEH and HH spaced at specific intervals. Though a maximum coordination number of 8 was observed, the presence of a single protein donor was noted to be mandatory in nickel coordination. The coordination pattern did not reveal any specific fold, nevertheless we report preferable residue spacing for specific structural architecture. In contrast, the analysis of nickel binding proteins from bacterial and archeal species revealed no common coordination patterns. Nickel binding sequence motifs were noted to be organism specific and protein class specific. As a result we identified about 13 signatures derived from 13 classes of nickel binding proteins. The specifications on nickel coordination presented in this paper will prove beneficial for developing better chelation strategies.

  13. 36 CFR 1010.4 - NEPA Compliance Coordinator.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false NEPA Compliance Coordinator. 1010.4 Section 1010.4 Parks, Forests, and Public Property PRESIDIO TRUST ENVIRONMENTAL QUALITY § 1010.4 NEPA Compliance Coordinator. (a) The NEPA Compliance Coordinator, as designated by the...

  14. Valuing the Leadership Role of University Unit Coordinators

    Science.gov (United States)

    Pepper, Coral; Roberts, Susan

    2016-01-01

    In this paper we describe the experiences of 64 unit coordinators across 15 Australian universities, gathered during 2011/2012 as part of an Office for Learning and Teaching (OLT) project. Our intention was to gain insight into how unit coordinators (academics who coordinate a discrete unit of study) perceive their role as leaders of learning in…

  15. Ab initio coordination chemistry for nickel chelation motifs.

    Directory of Open Access Journals (Sweden)

    R Jesu Jaya Sudan

    Full Text Available Chelation therapy is one of the most appreciated methods in the treatment of metal induced disease predisposition. Coordination chemistry provides a way to understand metal association in biological structures. In this work we have implemented coordination chemistry to study nickel coordination due to its high impact in industrial usage and thereby health consequences. This paper reports the analysis of nickel coordination from a large dataset of nickel bound structures and sequences. Coordination patterns predicted from the structures are reported in terms of donors, chelate length, coordination number, chelate geometry, structural fold and architecture. The analysis revealed histidine as the most favored residue in nickel coordination. The most common chelates identified were histidine based namely HHH, HDH, HEH and HH spaced at specific intervals. Though a maximum coordination number of 8 was observed, the presence of a single protein donor was noted to be mandatory in nickel coordination. The coordination pattern did not reveal any specific fold, nevertheless we report preferable residue spacing for specific structural architecture. In contrast, the analysis of nickel binding proteins from bacterial and archeal species revealed no common coordination patterns. Nickel binding sequence motifs were noted to be organism specific and protein class specific. As a result we identified about 13 signatures derived from 13 classes of nickel binding proteins. The specifications on nickel coordination presented in this paper will prove beneficial for developing better chelation strategies.

  16. DYNAMICS OF INTERHEMISPHERIC RELATIONSHIPS IN EARLY ONTOGENESIS

    Directory of Open Access Journals (Sweden)

    E.M. Berdichevskaia

    2011-12-01

    Full Text Available Studying cerebral hemispheric interaction and the principles of their coordination allow to understand the central adaptational and compensatory mechanisms in the early developmental process of children. Objectification of the level of motor function development in children in early ontogenesis, its relationship with the profile of interhemispheric organization of the brain, and its dynamics with age is highly relevant today. With the participation of 260 practically healthy children, including 74 children age 3 to 4 years and 186 age 6 to 7 years, we studied intra- and interhemispheric relations in the motor domain using the test of finger synkinesis in the early stages of childhood. Results showed that the amount of finger synkineses, and consequently the level of integration of intra- and interhemispheric relations in the brain of the child, depended on the child’s age. Besides, the magnitude, character, positive and negative dynamics of synkineses in the process of adaptation to school depend on the lateral phenotype.

  17. 32 CFR Appendix A to Part 80 - Procedures for the Provision of Early Intervention Services for Infants and Toddlers With...

    Science.gov (United States)

    2010-07-01

    ..., comprehensive, multidisciplinary, and intercomponent programs providing appropriate early intervention services... participation is requested by a parent. d. The Early Intervention Program Services Coordinator who has been... and the anticipated duration of such services. g. The name of the Early Intervention Program...

  18. Transitional coordination in Sudan (2006-08): lessons from the United Nations Resident Coordinator's Office.

    Science.gov (United States)

    Clarke, John N

    2013-07-01

    With the increase in internal conflicts following the end of the Cold War, the scale and scope of the United Nations' work in conflict and post-conflict environments grew markedly. As a result, the coordination of programming and policy in the transition from relief to recovery has been a central preoccupation of academics and practitioners alike. Intergovernmental bodies such as the United Nations Economic and Social Council (ECOSOC) have made these topics a subject of regular discussion, while some countries have altered their bureaucratic structures to respond more effectively in post-crisis settings, particularly in cases involving the deployment of national troops. The United Nations Resident Coordinator's Office in Sudan provides a model for other transitional countries and is a useful case study of the broader challenges of post-crisis programming. Effective coordination structures and planning/programming processes are identified as interdependent prerequisites for ensuring a successful transition from relief to recovery.

  19. [A theoretical analysis of coordination in the field of health care: application to coordinated care systems].

    Science.gov (United States)

    Sebai, Jihane

    2016-01-01

    Various organizational, functional or structural issues have led to a review of the foundations of the former health care system based on a traditional market segmentation between general practice and hospital medicine, and between health and social sectors and marked by competition between private and public sectors. The current reconfiguration of the health care system has resulted in “new” levers explained by the development of a new organizational reconfiguration of the primary health care model. Coordinated care structures (SSC) have been developed in this context by making coordination the cornerstone of relations between professionals to ensure global, continuous and quality health care. This article highlights the contributions of various theoretical approaches to the understanding of the concept of coordination in the analysis of the current specificity of health care.

  20. Supply chain coordination in industrial symbiosis

    DEFF Research Database (Denmark)

    Herczeg, Gabor; Akkerman, Renzo; Hauschild, Michael Zwicky

    2013-01-01

    Industrial symbiosis (IS) is a form of supply chain cooperation in industrial networks in order to achieve collective benefits by leveraging each other’s by-products and sharing services and utilities. This paper investigates the concept of IS from the perspective of supply chain coordination (SCC......). For this purpose a theoretical framework is built based on SCC aspects, which is subsequently used to analyze a case study. We conclude that research is scant on operational issues and trade-offs as well as on challenges in terms of logistical integration. Also small-scale examples are barely studied or modeled....

  1. Developmental dyspraxia and developmental coordination disorder.

    Science.gov (United States)

    Miyahara, M; Möbs, I

    1995-12-01

    This article discusses the role developmental dyspraxia plays in developmental coordination disorder (DCD), based upon a review of literature on apraxia, developmental dyspraxia, and DCD. Apraxia and dyspraxia have often been equated with DCD. However, it is argued that apraxia and dyspraxia primarily refer to the problems of motor sequencing and selection, which not all children with DCD exhibit. The author proposes to distinguish developmental dyspraxia from DCD. Other issues discussed include the assessment, etiology, and treatment of developmental dyspraxia and DCD, and the relationship between DCD and learning disabilities. A research agenda is offered regarding future directions to overcome current limitation.

  2. Coordinate time dependence in Quantum Gravity

    CERN Document Server

    Bojowald, M; Skirzewski, A; Bojowald, Martin; Singh, Parampreet; Skirzewski, Aureliano

    2004-01-01

    The intuitive classical space-time picture breaks down in quantum gravity, which makes a comparison and the development of semiclassical techniques quite complicated. Using ingredients of the group averaging method to solve constraints one can nevertheless introduce a classical coordinate time into the quantum theory, and use it to investigate the way a semiclassical continuous description emerges from discrete quantum evolution. Applying this technique to test effective classical equations of loop cosmology and their implications for inflation and bounces, we show that the effective semiclassical theory is in good agreement with the quantum description even at short scales.

  3. Crew coordination concepts: Continental Airlines CRM training

    Science.gov (United States)

    Christian, Darryl; Morgan, Alice

    1987-01-01

    The outline of the crew coordination concepts at Continental airlines is: (1) Present relevant theory: Contained in a pre-work package and in lecture/discussion form during the work course, (2) Discuss case examples: Contained in the pre-work for study and use during the course; and (3) Simulate practice problems: Introduced during the course as the beginning of an ongoing process. These concepts which are designed to address the problem pilots have in understanding the interaction between situations and their own theories of practice are briefly discussed.

  4. The Mortensen rule and efficient coordination unemployment

    DEFF Research Database (Denmark)

    Julien, Benoit; Kennes, John; King, Ian

    2006-01-01

    We apply the efficiency axioms of [Mortensen, D. (1982). Efficiency of mating, racing and related games. American Economic Review, 72 968–979.] to a set of matching games involving coordination frictions between buyers. These games include markets with finite numbers of buyers and sellers...... and markets with infinite numbers of heterogeneous buyers and homogenous sellers. We show that the Mortensen rule, but not the Hosios rule, gives constrained efficient allocations. We also show that the Mortensen rule is implemented by a simple auction...

  5. A Relativistic Algorithm with Isotropic Coordinates

    Directory of Open Access Journals (Sweden)

    S. A. Ngubelanga

    2013-01-01

    Full Text Available We study spherically symmetric spacetimes for matter distributions with isotropic pressures. We generate new exact solutions to the Einstein field equations which also contain isotropic pressures. We develop an algorithm that produces a new solution if a particular solution is known. The algorithm leads to a nonlinear Bernoulli equation which can be integrated in terms of arbitrary functions. We use a conformally flat metric to show that the integrals may be expressed in terms of elementary functions. It is important to note that we utilise isotropic coordinates unlike other treatments.

  6. A new sieve for distinct coordinate counting

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    We present a new sieve for the distinct coordinate counting problem.This significantly improves the classical inclusion-exclusion sieve for this problem,in the sense that the number of terms is reduced from 2(k 2) to k!,and reduced further to p(k) in the symmetric case,where p(k) denotes the number of partitions of k.As an illustration of applications,we give an in-depth study of a basic example arising from coding theory and graph theory.

  7. Towards reduction of Paradigm coordination models

    CERN Document Server

    Andova, Suzana; de Vink, Erik; 10.4204/EPTCS.60.1

    2011-01-01

    The coordination modelling language Paradigm addresses collaboration between components in terms of dynamic constraints. Within a Paradigm model, component dynamics are consistently specified at a detailed and a global level of abstraction. To enable automated verification of Paradigm models, a translation of Paradigm into process algebra has been defined in previous work. In this paper we investigate, guided by a client-server example, reduction of Paradigm models based on a notion of global inertness. Representation of Paradigm models as process algebraic specifications helps to establish a property-preserving equivalence relation between the original and the reduced Paradigm model. Experiments indicate that in this way larger Paradigm models can be analyzed.

  8. Supramolecular Chirality in Dynamic Coordination Chemistry

    Directory of Open Access Journals (Sweden)

    Hiroyuki Miyake

    2014-10-01

    Full Text Available Labile metal complexes have a useful coordination bond; which is weaker than a covalent C–C bond and is reversibly and dynamically formed and dissociated. Such labile metal complexes also can be used to construct chiral shapes and offer dynamic conversion of chiral molecular shapes in response to external stimuli. This review provides recent examples of chirality induction and describes the dynamic conversion systems produced by chiral metal complexes including labile metal centers, most of which respond to external stimuli by exhibiting sophisticated conversion phenomena.

  9. Electrothermal Coordination in Cable Based Transmission Grids

    DEFF Research Database (Denmark)

    Olsen, Rasmus Schmidt; Holbøll, Joachim; Gudmundsdottir, Unnur Stella

    2013-01-01

    Electrothermal coordination (ETC) is introduced for cable based transmission grids. ETC is the term covering operation and planning of transmission systems based on temperature, instead of current. ETC consists of one part covering the load conditions of the system and one covering the thermal...... to be beneficial for both operator and system planner. It is shown how the thermal behavior can be monitored in real-time during normal dynamic load and during emergencies. In that way, ETC enables cables to be loaded above their normal rating, while maintaining high reliability of the system, which potentially...

  10. Developmental coordination disorder: what is it?

    Science.gov (United States)

    Dewey, D; Wilson, B N

    2001-01-01

    This paper begins with a discussion of the historical basis for the concept of developmental coordination disorder (DCD). The definition of this disorder as it appears in the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) is then provided. The four diagnostic criteria proposed by the DSM-IV are used to describe the disorder. Problems associated with the assessment of DCD are discussed and suggestions for further research are identified. This is followed by a discussion of intervention approaches that can be used with children identified with DCD.

  11. Lorentz gauge quantization in synchronous coordinates

    CERN Document Server

    Garner, Christopher

    2016-01-01

    It has been shown that the Gupta-Bleuler method of quantization can be used to impose the Lorentz gauge condition in static space-times but not in cosmological space-times. This implies that the Gupta-Bleuler approach fails in general in non-static space-times. More recently, however, the Dirac method of quantizing constrained dynamical systems has been successfully employed to impose the Lorentz gauge in conformally flat space-times. In this paper we generalize this result by using Dirac's method to impose the Lorentz gauge in a general space-time region where the metric is expressed in synchronous coordinates.

  12. Coordinated Water Under Confinement Eases Sliding Friction

    Science.gov (United States)

    Defante, Adrian; Dhopotkar, Nishad; Dhinojwala, Ali

    Water is essential to a number of interfacial phenomena such as the lubrication of knee joints, protein folding, mass transport, and adsorption processes. We have used a biaxial friction cell to quantify underwater friction between a hydrophobic elastomeric lens and a hydrophobic self-assembled monolayer in the presence of surfactant solutions. To gain an understanding of the role of water in these processes we have coupled this measurement with surface sensitive sum frequency generation to directly probe the molecular constitution of the confined contact interface. We observe that role of confined coordinated water between two hydrophobic substrates covered with surfactants is the key to obtaining a low coefficient of friction.

  13. Coordination of engineering applications: Project summary

    Energy Technology Data Exchange (ETDEWEB)

    Cassidy, P.J.

    1996-08-31

    The purpose of this project was to focus on and coordinate several active engineering applications projects to optimize their integration. The end result of the project was to develop and demonstrate the capability of electronically receiving a part from the originating design agency, performing computer-aided engineering analyses, developing process plans, adding electronic input from numerous onsite systems, and producing an online operation sheet (manual) for viewing on a shop floor workstation. A successful demonstration of these applications was performed in December 1988.

  14. During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay.

    Science.gov (United States)

    Katsuyama, Tomonori; Comoglio, Federico; Seimiya, Makiko; Cabuy, Erik; Paro, Renato

    2015-05-05

    Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner involving local cell proliferation at the wound site. After disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation, and repatterning of the tissue. However, the interplay of signaling cascades driving these early reprogramming steps is not well-understood. Here, we profiled the transcriptome of regenerating cells in the early phase within 24 h after wounding. We found that JAK/STAT signaling becomes activated at the wound site and promotes regenerative cell proliferation in cooperation with Wingless (Wg) signaling. In addition, we showed that the expression of Drosophila insulin-like peptide 8 (dilp8), which encodes a paracrine peptide to delay the onset of pupariation, is controlled by JAK/STAT signaling in early regenerating discs. Our findings suggest that JAK/STAT signaling plays a pivotal role in coordinating regenerative disc growth with organismal developmental timing.

  15. Towards implementing coordinated healthy lifestyle promotion in primary care: a mixed method study

    Directory of Open Access Journals (Sweden)

    Kristin Thomas

    2015-08-01

    Full Text Available Background: Primary care is increasingly being encouraged to integrate healthy lifestyle promotion in routine care. However, implementation has been suboptimal. Coordinated care could facilitate lifestyle promotion practice but more empirical knowledge is needed about the implementation process of coordinated care initiatives. This study aimed to evaluate the implementation of a coordinated healthy lifestyle promotion initiative in a primary care setting.Methods: A mixed method, convergent, parallel design was used. Three primary care centres took part in a two-year research project. Data collection methods included individual interviews, document data and questionnaires. The General Theory of Implementation was used as a framework in the analysis to integrate the data sources.Results: Multi-disciplinary teams were implemented in the centres although the role of the teams as a resource for coordinated lifestyle promotion was not fully embedded at the centres. Embedding of the teams was challenged by differences among the staff, patients and team members on resources, commitment, social norms and roles.Conclusions: The study highlights the importance of identifying and engaging key stakeholders early in an implementation process. The findings showed how the development phase influenced the implementation and embedding processes, which add aspects to the General Theory of Implementation.

  16. Towards implementing coordinated healthy lifestyle promotion in primary care: a mixed method study

    Directory of Open Access Journals (Sweden)

    Kristin Thomas

    2015-08-01

    Full Text Available Background: Primary care is increasingly being encouraged to integrate healthy lifestyle promotion in routine care. However, implementation has been suboptimal. Coordinated care could facilitate lifestyle promotion practice but more empirical knowledge is needed about the implementation process of coordinated care initiatives. This study aimed to evaluate the implementation of a coordinated healthy lifestyle promotion initiative in a primary care setting. Methods: A mixed method, convergent, parallel design was used. Three primary care centres took part in a two-year research project. Data collection methods included individual interviews, document data and questionnaires. The General Theory of Implementation was used as a framework in the analysis to integrate the data sources. Results: Multi-disciplinary teams were implemented in the centres although the role of the teams as a resource for coordinated lifestyle promotion was not fully embedded at the centres. Embedding of the teams was challenged by differences among the staff, patients and team members on resources, commitment, social norms and roles. Conclusions: The study highlights the importance of identifying and engaging key stakeholders early in an implementation process. The findings showed how the development phase influenced the implementation and embedding processes, which add aspects to the General Theory of Implementation.

  17. Improving care coordination using organisational routines: care pathways as a coordination mechanism

    DEFF Research Database (Denmark)

    Prætorius, Thim

    2016-01-01

    Purpose: This conceptual article systematically applies theory of organisational routines to standardised care pathways. The explanatory power of routines is used to address open questions in the care pathway literature about their coordinating and organising role, the way they change and can...... be replicated, the way they are influenced by the organisation and the way they influence health care professionals. Design/methodology/approach: Theory of routines is systematically applied to the concept of care pathways in order to develop theoretically derived propositions. Findings: Care pathways mirror....... Originality/value: Theory on organisational routines offers fundamental, yet unexplored, insights into hospital processes, including in particular care coordination....

  18. The Role of a Burn Research Coordinator: A Guide for Novice Coordinators.

    Science.gov (United States)

    Honari, Shari; Caceres, Maria; Romo, Mariana; Gibran, Nicole S; Gamelli, Richard L

    2016-01-01

    As health-care complexity and costs increase, evidence-based research has become essential to the advancement of burn care. Multicenter trials involve procedures, regulations, and guidelines that require meticulous attention to details and strict adherence to compliance issues. Taking on a large, multicenter trial can be a daunting task for a new burn research coordinator. The purpose of this article is to provide a resource for new burn research coordinators in multicenter clinical trial planning, especially in the field of burns. The burn research coordinator must possess organizational and multitasking skills, attention to detail, professionalism, initiative, and motivation. The burn research coordinator must exercise five principles of practice: compliance, confidentiality, consistency and correctness, and collaboration. Compliance assures subject safety, study integrity, and burn center reputation. Confidentiality is essential, especially when handling sensitive health information. Maintaining subject privacy through secure links and destruction of linked data in a timely matter protects the subjects and complies with the regulations of many governing bodies. Consistency and correctness minimize human errors through continuous data validation and self-auditing and peer auditing. Collaboration between the Principal Investigator/burn research coordinator and all departments involved in the study maintains the study focus and allows for enforcement of procedures. Preparing a budget confirms adequate compensation for work done by the research team and can be broken down into the following five steps: protocol review, calculation of initial payment, establishment of indirect costs, calculation of direct costs, and budget negotiation. Over time, one becomes familiar with the details involved with study success. Advocating for subject safety and protocol adherence are of highest priority. Study design is the most important element that dictates the success of the

  19. Relative phase stability of bimanual and visuomanual rhythmic coordination patterns in children with a Developmental Coordination Disorder

    NARCIS (Netherlands)

    Volman, M.J.M.; Geuze, R.H.

    1998-01-01

    A dynamic pattern approach is used to examine the relative phase stability of rhythmic coordination in 24 children with a Developmental Coordination Disorder (DCD) and 24 matched controls in two functionally different tasks - a within-subject task (bimanual coordination) and a subject-environment ta

  20. Modulation of the coordination environment: a convenient approach to tailor magnetic anisotropy in seven coordinate Co(II) complexes.

    Science.gov (United States)

    Dey, Mamon; Dutta, Snigdha; Sarma, Bipul; Deka, Ramesh Ch; Gogoi, Nayanmoni

    2016-01-14

    The possibility of controlling magnetic anisotropy by tuning contribution of second order perturbation to spin-orbit coupling through modulation of the coordination environment is investigated. Subtle variation of the coordination environment triggers a remarkable deviation in the axial zero field splitting parameter of seven coordinate Co(II) complexes.

  1. Two distinct pathways for developmental coordination disorder: persistence and resolution.

    Science.gov (United States)

    Cantell, Marja H; Smyth, Mary M; Ahonen, Timo P

    2003-11-01

    This article describes the perceptual motor, educational and social outcome of early motor delay in a group of 17-18 year old Finnish adolescents who were originally evaluated at age 5. The study group consisted of 65 adolescents: 22 with significant motor problems (or developmental coordination disorder, DCD), 23 with minor motor problems (intermediate group) and 20 controls. The goal of this study was to reassess the results obtained when they were age 15 and to determine whether the variables used earlier could still discriminate the adolescents at age 17. The results showed that at age 17 all perceptual motor tasks differentiated the three groups. The DCD group performed less well than the control group on all tasks, with the intermediate group situated between these two. Discriminant function analyses showed that more classification errors occurred between the control and intermediate groups at age 17 than at age 15, suggesting that the distinction between these groups becomes more difficult with age. In the educational domain, similar to the findings at age 15, the adolescents with DCD had the lowest WAIS scores and shortest school careers of the three groups. In the social domain, as found two years earlier, the DCD group had the lowest perceptions of athletic and scholastic competence while the intermediate and control groups did not differ. In addition, the interview results indicated that the three groups were in different stages of identity development. In sum, the outcome at age 17 was a replication of the results obtained at age 15 and suggests two developmental paths for those with early perceptual motor problems: 'persistence' and 'catching up'.

  2. Coordination of health care in the Nordic countries

    DEFF Research Database (Denmark)

    Iversen, Tor; Anell, Anders; Häkkinen, Unto;

    2016-01-01

    Coordination of health care exists at many different levels and in many different forms. We describe the similarities and differences in coordination mechanisms among the Nordic countries. In some respects, the Nordic countries approach coordination problems in similar ways although differences...... exist. The overall pattern shows that Finland and Sweden have less country-wide coordination compared with the other countries. There are many questions and few answers with regard to which mechanisms work best. Hence, coordination mechanisms in health care seem to be an important area for further...

  3. Dynamical Structure of the Fields in the Light Cone Coordinates

    CERN Document Server

    Kargar, Kianoosh

    2016-01-01

    It is well-known that additional constraints emerge in light cone coordinates. We enumerate the number of physical modes in light cone coordinates and compare it with conventional coordinates. We show that the number of Schrodinger modes is divided by two in light cone coordinates. We study the effect of this reduction in the number ladder operators acting on physical states of a system. We analyse the scaler, spinor and vector field theories carefully to see the effect of changes in the dynamical structure of these theories from the view point of the reduction of Schrodinger modes in light-cone coordinates.

  4. Observable dynamics and coordinate systems for vehicle tracking

    CERN Document Server

    Altendorfer, Richard

    2010-01-01

    We investigate several coordinate systems and dynamical vector fields for target tracking to be used in driver assistance systems. We show how to express the discrete dynamics of maneuvering target vehicles in arbitrary coordinates starting from the target's and the own (ego) vehicle's assumed dynamical model in global coordinates. We clarify the notion of "ego compensation" and show how non-inertial effects are to be included when using a body-fixed coordinate system for target tracking. We finally compare the tracking error of different combinations of target tracking coordinates and dynamical vector fields for simulated data.

  5. Coordination of health care in the Nordic countries

    Directory of Open Access Journals (Sweden)

    Tor Iversen

    2016-04-01

    Full Text Available Coordination of health care exists at many different levels and in many different forms. We describe the similarities and differences in coordination mechanisms among the Nordic countries. In some respects, the Nordic countries approach coordination problems in similar ways although differences exist. The overall pattern shows that Finland and Sweden have less country-wide coordination compared with the other countries. There are many questions and few answers with regard to which mechanisms work best. Hence, coordination mechanisms in health care seem to be an important area for further research. We outline a few topics for future joint Nordic research in this area.

  6. Interpolation Error Estimates for Mean Value Coordinates over Convex Polygons.

    Science.gov (United States)

    Rand, Alexander; Gillette, Andrew; Bajaj, Chandrajit

    2013-08-01

    In a similar fashion to estimates shown for Harmonic, Wachspress, and Sibson coordinates in [Gillette et al., AiCM, to appear], we prove interpolation error estimates for the mean value coordinates on convex polygons suitable for standard finite element analysis. Our analysis is based on providing a uniform bound on the gradient of the mean value functions for all convex polygons of diameter one satisfying certain simple geometric restrictions. This work makes rigorous an observed practical advantage of the mean value coordinates: unlike Wachspress coordinates, the gradient of the mean value coordinates does not become large as interior angles of the polygon approach π.

  7. Overview of coordination contracts within forward and reverse supply chains

    DEFF Research Database (Denmark)

    Govindan, Kannan; Popiuc, M.N.; Diabat, A.

    2013-01-01

    Contracts are comprehensive coordination mechanisms used in both theory and practice to coordinate various supply chain structures. By focusing on the coordination by contracts of the forward and reverse supply chains, the intention of this paper is to (1) present an overview of contracting...... of detail used in designing the coordination models. The paper gives a complete overview of the literature that addresses coordination by contracts, structures and classifies the existing work, and draws a parallel between the research conducted on the forward supply chain and the research on the reverse...... supply chain. © 2013 Elsevier Ltd. All rights reserved....

  8. Retina-like sensor image coordinates transformation and display

    Science.gov (United States)

    Cao, Fengmei; Cao, Nan; Bai, Tingzhu; Song, Shengyu

    2015-03-01

    For a new kind of retina-like senor camera, the image acquisition, coordinates transformation and interpolation need to be realized. Both of the coordinates transformation and interpolation are computed in polar coordinate due to the sensor's particular pixels distribution. The image interpolation is based on sub-pixel interpolation and its relative weights are got in polar coordinates. The hardware platform is composed of retina-like senor camera, image grabber and PC. Combined the MIL and OpenCV library, the software program is composed in VC++ on VS 2010. Experience results show that the system can realizes the real-time image acquisition, coordinate transformation and interpolation.

  9. Modelling Local and Global Behaviour: Petri Nets and Event Coordination

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2012-01-01

    to address this problem, we developed the notation of coordination diagrams, which allows us to define the global behaviour of a software system on top of existing class diagrams. One of the major objectives of coordination diagrams was to make it easy to integrate them and the code generated from them...... call it the Event Coordination Notation (ECNO). ECNO’s coordination diagrams define the global behaviour of a system only: they define how the local behaviour is coordinated and jointly executed in so-called interactions. In principle, ECNO is independent from a specific notation for modelling...

  10. Prematurely delivered rats show improved motor coordination during sensory-evoked motor responses compared to age-matched controls.

    Science.gov (United States)

    Roberto, Megan E; Brumley, Michele R

    2014-05-10

    The amount of postnatal experience for perinatal rats was manipulated by delivering pups one day early (postconception day 21; PC21) by cesarean delivery and comparing their motor behavior to age-matched controls on PC22 (the typical day of birth). On PC22, pups were tested on multiple measures of motor coordination: leg extension response (LER), facial wiping, contact righting, and fore- and hindlimb stepping. The LER and facial wiping provided measures of synchronous hind- and forelimb coordination, respectively, and were sensory-evoked. Contact righting also was sensory-evoked and provided a measure of axial coordination. Stepping provided a measure of alternated forelimb and hindlimb coordination and was induced with the serotonin receptor agonist quipazine. Pups that were delivered prematurely and spent an additional day in the postnatal environment showed more bilateral limb coordination during expression of the LER and facial wiping, as well as a more mature righting strategy, compared to controls. These findings suggest that experience around the time of birth shapes motor coordination and the expression of species-typical behavior in the developing rat.

  11. TRANSFER PRICING FOR COORDINATION AND PROFIT ALLOCATION

    Directory of Open Access Journals (Sweden)

    Jan Thomas Martini

    2011-09-01

    Full Text Available This paper examines coordination and profit allocation in a profit-center organization using a single transfer price. The model includes compensations, taxes, and minority interests of two divisions deciding on capacity and sales. The analysis covers arm’s length transfer prices which are either administered by central management or negotiated by the divisions. Administered transfer prices refer to past transactions and therefore maximize firm-wide profit net of divisional compensations, taxes, and minority profit shares only for given decentralized decisions. From an ex-ante perspective, it is shown that adverse effects on coordination may result in inefficient divisional profits of which all stakeholders suffer. We motivate a positive effect of advance pricing agreements, intra-firm guidelines, and restrictive treatments of changes in the firm’s accounting policy. By contrast, negotiations ignore compensations, taxes, and minority shares but yield efficient divisional profits. Negotiations seem compelling as they perfectly reflect the arm’s length principle. Moreover, common practices such as arbitration or one-step pricing schemes allow the firm to engage in manipulation at the expense of other stakeholders.

  12. Coordinated Energy Management in Heterogeneous Processors

    Directory of Open Access Journals (Sweden)

    Indrani Paul

    2014-01-01

    Full Text Available This paper examines energy management in a heterogeneous processor consisting of an integrated CPU–GPU for high-performance computing (HPC applications. Energy management for HPC applications is challenged by their uncompromising performance requirements and complicated by the need for coordinating energy management across distinct core types – a new and less understood problem. We examine the intra-node CPU–GPU frequency sensitivity of HPC applications on tightly coupled CPU–GPU architectures as the first step in understanding power and performance optimization for a heterogeneous multi-node HPC system. The insights from this analysis form the basis of a coordinated energy management scheme, called DynaCo, for integrated CPU–GPU architectures. We implement DynaCo on a modern heterogeneous processor and compare its performance to a state-of-the-art power- and performance-management algorithm. DynaCo improves measured average energy-delay squared (ED2 product by up to 30% with less than 2% average performance loss across several exascale and other HPC workloads.

  13. Coordinates of anthropogenic features on the Moon

    Science.gov (United States)

    Wagner, R. V.; Nelson, D. M.; Plescia, J. B.; Robinson, M. S.; Speyerer, E. J.; Mazarico, E.

    2017-02-01

    High-resolution images from the Lunar Reconnaissance Orbiter Camera (LROC) Narrow Angle Camera (NAC) reveal the landing locations of recent and historic spacecraft and associated impact sites across the lunar surface. Using multiple images of each site acquired between 2009 and 2015, an improved Lunar Reconnaissance Orbiter (LRO) ephemeris, and a temperature-dependent camera orientation model, we derived accurate coordinates (<12 m) for each soft-landed spacecraft, rover, deployed scientific payload, and spacecraft impact crater that we have identified. Accurate coordinates enhance the scientific interpretations of data returned by the surface instruments and of returned samples of the Apollo and Luna sites. In addition, knowledge of the sizes and positions of craters formed as the result of impacting spacecraft provides key benchmarks into the relationship between energy and crater size, as well as calibration points for reanalyzing seismic measurements acquired during the Apollo program. We identified the impact craters for the three spacecraft that impacted the surface during the LRO mission by comparing before and after NAC images.

  14. Understanding how animal groups achieve coordinated movement.

    Science.gov (United States)

    Herbert-Read, J E

    2016-10-01

    Moving animal groups display remarkable feats of coordination. This coordination is largely achieved when individuals adjust their movement in response to their neighbours' movements and positions. Recent advancements in automated tracking technologies, including computer vision and GPS, now allow researchers to gather large amounts of data on the movements and positions of individuals in groups. Furthermore, analytical techniques from fields such as statistical physics now allow us to identify the precise interaction rules used by animals on the move. These interaction rules differ not only between species, but also between individuals in the same group. These differences have wide-ranging implications, affecting how groups make collective decisions and driving the evolution of collective motion. Here, I describe how trajectory data can be used to infer how animals interact in moving groups. I give examples of the similarities and differences in the spatial and directional organisations of animal groups between species, and discuss the rules that animals use to achieve this organisation. I then explore how groups of the same species can exhibit different structures, and ask whether this results from individuals adapting their interaction rules. I then examine how the interaction rules between individuals in the same groups can also differ, and discuss how this can affect ecological and evolutionary processes. Finally, I suggest areas of future research.

  15. Canonical Coordinates for Retino-Cortical Magnification

    Directory of Open Access Journals (Sweden)

    Luc Florack

    2014-02-01

    Full Text Available A geometric model for a biologically-inspired visual front-end is proposed, based on an isotropic, scale-invariant two-form field. The model incorporates a foveal property typical of biological visual systems, with an approximately linear decrease of resolution as a function of eccentricity, and by a physical size constant that measures the radius of the geometric foveola, the central region characterized by maximal resolving power. It admits a description in singularity-free canonical coordinates generalizing the familiar log-polar coordinates and reducing to these in the asymptotic case of negligibly-sized geometric foveola or, equivalently, at peripheral locations in the visual field. It has predictive power to the extent that quantitative geometric relationships pertaining to retino-cortical magnification along the primary visual pathway, such as receptive field size distribution and spatial arrangement in retina and striate cortex, can be deduced in a principled manner. The biological plausibility of the model is demonstrated by comparison with known facts of human vision.

  16. Coordination of autophagy with other cellular activities

    Institute of Scientific and Technical Information of China (English)

    Yan WANG; Zheng-hong QIN

    2013-01-01

    The cell biological phenomenon of autophagy has attracted increasing attention in recent years,partly as a consequence of the discovery of key components of its cellular machinery.Autophagy plays a crucial role in a myriad of cellular functions.Autophagy has its own regulatory mechanisms,but this process is not isolated.Autophagy is coordinated with other cellular activities to maintain cell homeostasis.Autophagy is critical for a range of human physiological processes.The multifunctional roles of autophagy are explained by its ability to interact with several key components of various cell pathways.In this review,we focus on the coordination between autophagy and other physiological processes,including the ubiquitin-proteasome system (UPS),energy homeostasis,aging,programmed cell death,the immune responses,microbial invasion and inflammation.The insights gained from investigating autophagic networks should increase our understanding of their roles in human diseases and their potential as targets for therapeutic intervention.

  17. Desynchronizing Electrical and Sensory Coordinated Reset Neuromodulation

    Directory of Open Access Journals (Sweden)

    Oleksandr V. Popovych

    2012-03-01

    Full Text Available Coordinated reset (CR stimulation is a desynchronizing stimulation technique based on timely coordinated phase resets of sub-populations of a synchronized neuronal ensemble. It has initially been computationally developed for electrical deep brain stimulation (DBS,to enable an effective desynchronization and unlearning of pathological synchrony and connectivity (anti-kindling. Here we computationally show for ensembles of spiking and bursting model neurons interacting via excitatory and inhibitory adaptive synapses that a phase reset of neuronal populations as well as a desynchronization and an anti-kindling can robustly be achieved by direct electrical stimulation or indirect (synaptically-mediated excitatory and inhibitory stimulation.Our findings are relevant for DBS as well as for sensory stimulation in neurological disorders characterized by pathological neuronalsynchrony. Based on the obtained results, we may expect that the local effects in the vicinity of a depth electrode (realized by direct stimulation of the neurons' somata or stimulation of axon terminals and the non-local CR effects (realized by stimulation of excitatory or inhibitory efferent fibers of deep brain CR neuromodulation may be similar or even identical. Furthermore, ourresults indicate that an effective desynchronization and anti-kindlingcan even be achieved by non-invasive, sensory CR neuromodulation. We discuss the concept of sensory CR neuromodulation in the context of neurological disorders.

  18. Coordination of breathing with nonrespiratory activities.

    Science.gov (United States)

    Bartlett, Donald; Leiter, James C

    2012-04-01

    Many articles in this section of Comprehensive Physiology are concerned with the development and function of a central pattern generator (CPG) for the control of breathing in vertebrate animals. The action of the respiratory CPG is extensively modified by cortical and other descending influences as well as by feedback from peripheral sensory systems. The central nervous system also incorporates other CPGs, which orchestrate a wide variety of discrete and repetitive, voluntary and involuntary movements. The coordination of breathing with these other activities requires interaction and coordination between the respiratory CPG and those governing the nonrespiratory activities. Most of these interactions are complex and poorly understood. They seem to involve both conventional synaptic crosstalk between groups of neurons and fluid identity of neurons as belonging to one CPG or another: neurons that normally participate in breathing may be temporarily borrowed or hijacked by a competing or interrupting activity. This review explores the control of breathing as it is influenced by many activities that are generally considered to be nonrespiratory. The mechanistic detail varies greatly among topics, reflecting the wide variety of pertinent experiments.

  19. 2D COORDINATE TRANSFORMATION USING ARTIFICIAL NEURAL NETWORKS

    Directory of Open Access Journals (Sweden)

    B. Konakoglu

    2016-10-01

    Full Text Available Two coordinate systems used in Turkey, namely the ED50 (European Datum 1950 and ITRF96 (International Terrestrial Reference Frame 1996 coordinate systems. In most cases, it is necessary to conduct transformation from one coordinate system to another. The artificial neural network (ANN is a new method for coordinate transformation. One of the biggest advantages of the ANN is that it can determine the relationship between two coordinate systems without a mathematical model. The aim of this study was to investigate the performances of three different ANN models (Feed Forward Back Propagation (FFBP, Cascade Forward Back Propagation (CFBP and Radial Basis Function Neural Network (RBFNN with regard to 2D coordinate transformation. To do this, three data sets were used for the same study area, the city of Trabzon. The coordinates of data sets were measured in the ED50 and ITRF96 coordinate systems by using RTK-GPS technique. Performance of each transformation method was investigated by using the coordinate differences between the known and estimated coordinates. The results showed that the ANN algorithms can be used for 2D coordinate transformation in cases where optimum model parameters are selected.

  20. Analysis of coordination between breathing and walking rhythms in humans.

    Science.gov (United States)

    Rassler, B; Kohl, J

    1996-12-01

    We investigated the coordination between breathing and walking in humans to elucidate whether the coordination degree depends more on metabolic load or on breathing or stride frequencies and whether coordination causes energetic economization expressed by reduction of oxygen uptake (VO2). Eighteen healthy volunteers walked on a treadmill at three load levels realized by different velocities and slopes. We analyzed the time intervals between step onset and the onset of inspiration or expiration related to stride duration (relative phase, phi) and computed the relative-phase histogram to assess the degree of coordination. The degree of coordination between breathing and stepping enhanced with increasing walking speed. Increased work load achieved by slope at constant walking speed improved coordination only slightly. No significant VO2 reduction due to coordination was found. VO2 was more strongly related to ventilation variations occurring during coordination. Also the sympathetic tone reflected by the spectral power of heart rate variability was not reduced during coordination. We conclude that during walking the coordination degree increases with increasing stride frequency and that coordination does not necessarily cause energetic economization.