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Sample records for chromatinfor coordinated expression

  1. SATB1 packages densely-looped, transciptionally-active chromatinfor coordinated expression of cytokine genes

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Shutao; Lee, Charles C.; Kohwi-Shigematsu, Terumi

    2006-05-23

    SATB1 is an important regulator of nuclear architecture that anchors specialized DNA sequences onto its cage-like network and recruits chromatin remodeling/modifying factors to control gene transcription. We studied the role of SATB1 in regulating the coordinated expression of Il5, Il4, and Il13 from the 200kb cytokine gene cluster region of mouse chromosome 11 during T-helper 2 (Th2)-cell activation. We show that upon cell activation, SATB1 is rapidly induced to form a unique transcriptionally-active chromatin structure that includes the cytokine gene region. Chromatin is folded into numerous small loops all anchored by SATB1, is histone H3 acetylated at lysine 9/14, and associated with Th2-specific factors, GATA3, STAT6, c-Maf, the chromatin-remodeling enzyme Brg-1, and RNA polymerase II across the 200kb region. Before activation, the chromatin displays some of these features, such as association with GATA3 and STAT6, but these were insufficient for cytokine gene expression. Using RNA interference (RNAi), we show that upon cell activation, SATB1 is not only required for chromatin folding into dense loops, but also for c-Maf induction and subsequently for Il4, Il5, and Il13 transcription. Our results show that SATB1 is an important determinant for chromatin architecture that constitutes a novel higher-order, transcriptionally-active chromatin structure upon Th2-cell activation.

  2. Coordination of gene expression between organellar and nuclear genomes

    Science.gov (United States)

    Woodson, Jesse D.; Chory, Joanne

    2016-01-01

    Following the acquisition of chloroplasts and mitochondria by eukaryotic cells during endosymbiotic evolution, most of the genes in these organelles were either lost or transferred to the nucleus. Encoding organelle-destined proteins in the nucleus allows for host control of the organelle. In return, organelles send signals to the nucleus to coordinate nuclear and organellar activities. In photosynthetic eukaryotes, additional interactions exist between mitochondria and chloroplasts. Here we review recent advances in elucidating the intracellular signalling pathways that coordinate gene expression between organelles and the nucleus, with a focus on photosynthetic plants. PMID:18368053

  3. Coordination of murine parotid secretory protein and salivary amylase expression.

    OpenAIRE

    Poulsen, K; Jakobsen, B K; Mikkelsen, B M; Harmark, K; Nielsen, J T; Hjorth, J P

    1986-01-01

    PSP, parotid secretory protein, and salivary amylase are the major secretory proteins of mouse parotid gland where they appear in a constant ratio. Here we describe the isolation of the PSP gene and show through expression analysis on this and the salivary amylase gene that the two genes are transcribed in a coordinate fashion in adult animals, whereas the activation profiles are different during postnatal development. An explanation is put forward that involves activation of the genes at dif...

  4. Coordinated Changes in Gene Expression Throughout Encystation of Giardia intestinalis.

    Science.gov (United States)

    Einarsson, Elin; Troell, Karin; Hoeppner, Marc P; Grabherr, Manfred; Ribacke, Ulf; Svärd, Staffan G

    2016-03-01

    Differentiation into infectious cysts through the process of encystation is crucial for transmission and survival of the intestinal protozoan parasite Giardia intestinalis. Hitherto the majority of studies have focused on the early events, leaving late encystation poorly defined. In order to further study encystation, focusing on the later events, we developed a new encystation protocol that generates a higher yield of mature cysts compared to standard methods. Transcriptome changes during the entire differentiation from trophozoites to cysts were thereafter studied using RNA sequencing (RNA-seq). A high level of periodicity was observed for up- and down-regulated genes, both at the level of the entire transcriptome and putative regulators. This suggests the trajectory of differentiation to be coordinated through developmentally linked gene regulatory activities. Our study identifies a core of 13 genes that are consistently up-regulated during initial encystation. Of these, two constitute previously uncharacterized proteins that we were able to localize to a new type of encystation-specific vesicles. Interestingly, the largest transcriptional changes were seen in the late phase of encystation with the majority of the highly up-regulated genes encoding hypothetical proteins. Several of these were epitope-tagged and localized to further characterize these previously unknown genetic components of encystation and possibly excystation. Finally, we also detected a switch of variant specific surface proteins (VSPs) in the late phase of encystation. This occurred at the same time as nuclear division and DNA replication, suggesting a potential link between the processes. PMID:27015092

  5. Single-cell transcriptome analysis reveals coordinated ectopic gene expression patterns in medullary thymic epithelial cells

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    Brennecke, Philip; Reyes, Alejandro; Pinto, Sheena; Rattay, Kristin; Nguyen, Michelle; Küchler, Rita; Huber, Wolfgang; Kyewski, Bruno; Steinmetz, Lars M.

    2015-01-01

    Expression of tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential for self-tolerance induction and prevents autoimmunity, with each TRA being expressed in only a few mTECs. How this process is regulated in single mTECs and coordinated at the population level, such that the varied single-cell patterns add up to faithfully represent TRAs, is poorly understood. Here we used single-cell RNA-sequencing and provide evidence for numerous recurring TRA co-expression patterns, each present in only a subset of mTECs. Co-expressed genes clustered in the genome and showed enhanced chromatin accessibility. Our findings characterize TRA expression in mTECs as a coordinated process, which might involve local re-modeling of chromatin and thus ensures a comprehensive representation of the immunological self. PMID:26237553

  6. Coordinated Vascular Endothelial Growth Factor Expression and Signaling During Skeletal Myogenic Differentiation

    OpenAIRE

    Bryan, Brad A; Walshe, Tony E.; Mitchell, Dianne C; Havumaki, Josh S.; Saint-Geniez, Magali; Maharaj, Arindel S.; Maldonado, Angel E.; D'Amore, Patricia A.

    2008-01-01

    Angiogenesis is largely controlled by hypoxia-driven transcriptional up-regulation and secretion of vascular endothelial growth factor (VEGF) and its binding to the endothelial cell tyrosine receptor kinases, VEGFR1 and VEGFR2. Recent expression analysis suggests that VEGF is expressed in a cell-specific manner in normoxic adult tissue; however, the transcriptional regulation and role of VEGF in these tissues remains fundamentally unknown. In this report we demonstrate that VEGF is coordinate...

  7. Coordinated transcription factor and promoter engineering to establish strong expression elements in Saccharomyces cerevisiae.

    Science.gov (United States)

    Leavitt, John M; Tong, Alice; Tong, Joyce; Pattie, Jonathan; Alper, Hal S

    2016-07-01

    Gene expression requires the coordination of trans-acting factors and cis-DNA elements to initiate transcription. Here we present a coordinated approach that combines cis-acting element engineering with mutant trans-acting factors to engineer yeast promoters. Specifically, we first construct a hybrid promoter based on the ARO9 upstream region that exhibits high constitutive and inducible expression with respect to exogenous tryptophan. Next, we perform protein engineering to identify a mutant Aro80p that affords both high constitutive expression while retaining inducible traits. We then use this mutant trans-acting factor to drive expression and generate ultra-strong promoters with transcriptional output roughly 2 fold higher than TDH3 (GPD), one of the strongest promoters to-date. Finally, we used this element to construct a modular expression system capable of staged outputs resulting in a system with nearly 6-fold, 12-fold and 15-fold expression relative to the off-state. This work further highlights the potential of using endogenous transcription factors (including mutant factors) along with hybrid promoters to expand the yeast synthetic biology toolbox. PMID:27152757

  8. Spatially coordinated replication and minimization of expression noise constrain three-dimensional organization of yeast genome.

    Science.gov (United States)

    Singh, Arashdeep; Bagadia, Meenakshi; Sandhu, Kuljeet Singh

    2016-04-01

    Despite recent advances, the underlying functional constraints that shape the three-dimensional organization of eukaryotic genome are not entirely clear. Through comprehensive multivariate analyses of genome-wide datasets, we show thatcisandtransinteractions in yeast genome have significantly distinct functional associations. In particular, (i) thetransinteractions are constrained by coordinated replication and co-varying mutation rates of early replicating domains through interactions among early origins, whilecisinteractions are constrained by coordination of late replication through interactions among late origins; (ii)cisandtransinteractions exhibit differential preference for nucleosome occupancy; (iii)cisinteractions are also constrained by the essentiality and co-fitness of interacting genes. Essential gene clusters associate with high average interaction frequency, relatively short-range interactions of low variance, and exhibit less fluctuations in chromatin conformation, marking a physically restrained state of engaged loci that, we suggest, is important to mitigate the epigenetic errors by restricting the spatial mobility of loci. Indeed, the genes with lower expression noise associate with relatively short-range interactions of lower variance and exhibit relatively higher average interaction frequency, a property that is conserved acrossEscherichia coli,yeast, and mESCs. Altogether, our observations highlight the coordination of replication and the minimization of expression noise, not necessarily co-expression of genes, as potent evolutionary constraints shaping the spatial organization of yeast genome. PMID:26932984

  9. The DREAM complex: master coordinator of cell cycle-dependent gene expression.

    Science.gov (United States)

    Sadasivam, Subhashini; DeCaprio, James A

    2013-08-01

    The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis. PMID:23842645

  10. The DREAM complex: Master coordinator of cell cycle dependent gene expression

    Science.gov (United States)

    Sadasivam, Subhashini; DeCaprio, James A.

    2014-01-01

    Preface The dimerization partner (DP), retinoblastoma (RB)-like, E2F and MuvB (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and FOXM1. DREAM mediates gene repression during G0 and coordinates periodic gene expression with peaks during G1/S and G2/M. Perturbations in DREAM regulation shift the balance from quiescence towards proliferation and contribute to increased mitotic gene expression levels frequently observed in cancers with poor prognosis. PMID:23842645

  11. The DREAM complex: Master coordinator of cell cycle dependent gene expression

    OpenAIRE

    Sadasivam, Subhashini; DeCaprio, James A.

    2013-01-01

    The dimerization partner (DP), retinoblastoma (RB)-like, E2F and MuvB (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and FOXM1. DREAM mediates gene repression during G0 and coordinates periodic gene expression with peaks during G1/S and G2/M. Perturbations in DREAM regulation shift the balance from quiescence towards proliferation and contribute to increased mitotic gene expression levels frequently observed in cance...

  12. A combinatorial bidirectional and bicistronic approach for coordinated multi-gene expression in corn.

    Science.gov (United States)

    Kumar, Sandeep; AlAbed, Diaa; Whitteck, John T; Chen, Wei; Bennett, Sara; Asberry, Andrew; Wang, Xiujuan; DeSloover, Daniel; Rangasamy, Murugesan; Wright, Terry R; Gupta, Manju

    2015-03-01

    Transgene stacking in trait development process through genetic engineering is becoming complex with increased number of desired traits and multiple modes of action for each trait. We demonstrate here a novel gene stacking strategy by combining bidirectional promoter (BDP) and bicistronic approaches to drive coordinated expression of multi-genes in corn. A unidirectional promoter, Ubiquitin-1 (ZMUbi1), from Zea mays was first converted into a synthetic BDP, such that a single promoter can direct the expression of two genes from each end of the promoter. The BDP system was then combined with a bicistronic organization of genes at both ends of the promoter by using a Thosea asigna virus 2A auto-cleaving domain. With this gene stacking configuration, we have successfully obtained expression in transgenic corn of four transgenes; three transgenes conferring insect (cry34Ab1 and cry35Ab1) and herbicide (aad1) resistance, and a phiyfp reporter gene using a single ZMUbi1 bidirectional promoter. Gene expression analyses of transgenic corn plants confirmed better coordinated expression of the four genes compared to constructs driving each gene by independent unidirectional ZmUbi1 promoter. To our knowledge, this is the first report that demonstrates application of a single promoter for co-regulation of multiple genes in a crop plant. This stacking technology would be useful for engineering metabolic pathways both for basic and applied research. PMID:25657118

  13. Coordinating gene expression and axon assembly to control axon growth: potential role of GSK3 signaling

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    Fengquan Zhou

    2012-02-01

    Full Text Available Axon growth requires coordinated regulation of gene expression in the neuronal soma, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. Glycogen synthase kinase 3 (GSK3 signaling has recently been shown to play key roles in regulation of axonal transport and cytoskeletal assembly during axon growth. GSK3 signaling is also known to regulate gene expression via controlling the functions of many transcription factors, suggesting that GSK3 may be an important regulator of gene transcription supporting axon growth. Here we will review signaling pathways that control local axon assembly at the growth cone and gene expression in the soma during developmental or regenerative axon growth and discuss the potential involvement of GSK3 signaling in these processes, with a particular focus on how GSK3 signaling modulates the function of axon growth-associated transcription factors.

  14. Detecting coordinated regulation of multi-protein complexes using logic analysis of gene expression

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    Yeates Todd O

    2009-12-01

    Full Text Available Abstract Background Many of the functional units in cells are multi-protein complexes such as RNA polymerase, the ribosome, and the proteasome. For such units to work together, one might expect a high level of regulation to enable co-appearance or repression of sets of complexes at the required time. However, this type of coordinated regulation between whole complexes is difficult to detect by existing methods for analyzing mRNA co-expression. We propose a new methodology that is able to detect such higher order relationships. Results We detect coordinated regulation of multiple protein complexes using logic analysis of gene expression data. Specifically, we identify gene triplets composed of genes whose expression profiles are found to be related by various types of logic functions. In order to focus on complexes, we associate the members of a gene triplet with the distinct protein complexes to which they belong. In this way, we identify complexes related by specific kinds of regulatory relationships. For example, we may find that the transcription of complex C is increased only if the transcription of both complex A AND complex B is repressed. We identify hundreds of examples of coordinated regulation among complexes under various stress conditions. Many of these examples involve the ribosome. Some of our examples have been previously identified in the literature, while others are novel. One notable example is the relationship between the transcription of the ribosome, RNA polymerase and mannosyltransferase II, which is involved in N-linked glycan processing in the Golgi. Conclusions The analysis proposed here focuses on relationships among triplets of genes that are not evident when genes are examined in a pairwise fashion as in typical clustering methods. By grouping gene triplets, we are able to decipher coordinated regulation among sets of three complexes. Moreover, using all triplets that involve coordinated regulation with the ribosome

  15. Aspergillus fumigatus allergen expression is coordinately regulated in response to hydrogen peroxide and cyclic AMP

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    Bowyer Paul

    2010-11-01

    Full Text Available Abstract Background A. fumigatus has been associated with a wide spectrum of allergic disorders such as ABPA or SAFS. It is poorly understood what allergens in particular are being expressed during fungal invasion and which are responsible for stimulation of immune responses. Study of the dynamics of allergen production by fungi may lead to insights into how allergens are presented to the immune system. Methods Expression of 17 A. fumigatus allergen genes was examined in response to various culture conditions and stimuli as well as in the presence of macrophages in order to mimic conditions encountered in the lung. Results Expression of 14/17 allergen genes was strongly induced by oxidative stress caused by hydrogen peroxide (Asp f 1, -2, -4, -5, -6, -7, -8, -10, -13, -17 and -18, all >10-fold and Asp f 11, -12, and -22, 5-10-fold and 16/17 allergen genes were repressed in the presence of cAMP. The 4 protease allergen genes (Asp f -5, -10, -13 and -18 were expressed at very low levels compared to the comparator (β-tubulin under all other conditions examined. Mild heat shock, anoxia, lipid and presence of macrophages did not result in coordinated changes in allergen gene expression. Growth on lipid as sole carbon source contributed to the moderate induction of most of the allergen genes. Heat shock (37°C > 42°C caused moderate repression in 11/17 genes (Asp f 1, -2, -4, -5, -6, -9, -10, -13, -17, -18 and -23 (2- to 9-fold, which was mostly evident for Asp f 1 and -9 (~9-fold. Anaerobic stress led to moderate induction of 13/17 genes (1.1 to 4-fold with one, Asp f 8 induced over 10-fold when grown under mineral oil. Complex changes were seen in gene expression during co-culture of A. fumigatus with macrophages. Conclusions Remarkable coordination of allergen gene expression in response to a specific condition (oxidative stress or the presence of cAMP has been observed, implying that a single biological stimulus may play a role in allergen gene

  16. Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex.

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    Stanley I Rapoport

    Full Text Available Phosphoinositides, lipid-signaling molecules, participate in diverse brain processes within a wide metabolic cascade.Gene transcriptional networks coordinately regulate the phosphoinositide cascade during human brain Development and Aging.We used the public BrainCloud database for human dorsolateral prefrontal cortex to examine age-related expression levels of 49 phosphoinositide metabolic genes during Development (0 to 20+ years and Aging (21+ years.We identified three groups of partially overlapping genes in each of the two intervals, with similar intergroup correlations despite marked phenotypic differences between Aging and Development. In each interval, ITPKB, PLCD1, PIK3R3, ISYNA1, IMPA2, INPPL1, PI4KB, and AKT1 are in Group 1, PIK3CB, PTEN, PIK3CA, and IMPA1 in Group 2, and SACM1L, PI3KR4, INPP5A, SYNJ1, and PLCB1 in Group 3. Ten of the genes change expression nonlinearly during Development, suggesting involvement in rapidly changing neuronal, glial and myelination events. Correlated transcription for some gene pairs likely is facilitated by colocalization on the same chromosome band.Stable coordinated gene transcriptional networks regulate brain phosphoinositide metabolic pathways during human Development and Aging.

  17. Coordinated Regulation of Gene Expression for Carotenoid Metabolism in Chlamydomonas reinhardtii

    Institute of Scientific and Technical Information of China (English)

    Tian-Hu Sun; Cheng-Qian Liu; Yuan-Yuan Hui; Wen-Kai Wu; Zhi-Gang Zhou; Shan Lu

    2010-01-01

    Carotenoids are important plant pigments for both light harvesting and photooxidation protection.Using the model system of the unicellular green alga Chlamydomonas reinhardtii,we characterized the regulation of gene expression for carotenoid metabolism by quantifying changes in the transcript abundance of dxs,dxr and ipi in the plastidic methylerythritol phosphate pathway and of ggps,psy,pds,lcyb and bchy,directly involved in carotenoid metabolism,under different photoperiod,light and metabolite treatments.The expression of these genes fluctuated with light/dark shifting.Light treatment also promoted the accumulation of transcripts of all these genes.Of the genes studied,dxs,ggps and lcyb displayed the typical circadian pattern by retaining a rhythmic fluctuation of transcript abundance under both constant light and constant dark entrainments.The expression of these genes could also be regulated by metabolic intermediates.For example,ggps was significantly suppressed by a geranylgeranyl pyrophosphate supplement and ipi was upregulated by isopentenyl pyrophosphate.Furthermore,CrOr,a C.reinhardtii homolog of the recently characterized Or gene that accounts for carotenoid accumulation,also showed co-expression with carotenoid biosynthetic genes such as pds and lcyb.Our data suggest a coordinated regulation on carotenoid metabolism in C.reinhardtii at the transcriptional level.

  18. Coordination of gene expression of arachidonic and docosahexaenoic acid cascade enzymes during human brain development and aging.

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    Veronica H Ryan

    Full Text Available The polyunsaturated arachidonic and docosahexaenoic acids (AA and DHA participate in cell membrane synthesis during neurodevelopment, neuroplasticity, and neurotransmission throughout life. Each is metabolized via coupled enzymatic reactions within separate but interacting metabolic cascades.AA and DHA pathway genes are coordinately expressed and underlie cascade interactions during human brain development and aging.The BrainCloud database for human non-pathological prefrontal cortex gene expression was used to quantify postnatal age changes in mRNA expression of 34 genes involved in AA and DHA metabolism.Expression patterns were split into Development (0 to 20 years and Aging (21 to 78 years intervals. Expression of genes for cytosolic phospholipases A2 (cPLA2, cyclooxygenases (COX-1 and -2, and other AA cascade enzymes, correlated closely with age during Development, less so during Aging. Expression of DHA cascade enzymes was less inter-correlated in each period, but often changed in the opposite direction to expression of AA cascade genes. Except for the PLA2G4A (cPLA2 IVA and PTGS2 (COX-2 genes at 1q25, highly inter-correlated genes were at distant chromosomal loci.Coordinated age-related gene expression during the brain Development and Aging intervals likely underlies coupled changes in enzymes of the AA and DHA cascades and largely occur through distant transcriptional regulation. Healthy brain aging does not show upregulation of PLA2G4 or PTGS2 expression, which was found in Alzheimer's disease.

  19. Location, location, location. Salmonella senses ethanolamine to gauge distinct host environments and coordinate gene expression

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    Christopher J. Anderson

    2016-01-01

    Full Text Available Chemical and nutrient signaling mediate all cellular processes, ensuring survival in response to changing environmental conditions. Ethanolamine is a component of phosphatidylethanolamine, a major phospholipid of mammalian and bacterial cell membranes. Ethanolamine is abundant in the gastrointestinal (GI tract from dietary sources as well as from the normal turnover of intestinal epithelial and bacterial cells in the gut. Additionally, mammalian cells maintain intracellular ethanolamine concentrations through low and high-affinity uptake systems and the internal recycling of phosphatidylethanolamine; therefore, ethanolamine is ubiquitous throughout the mammalian host. Although ethanolamine has profound signaling activity within mammalian cells by modulating inflammatory responses and intestinal physiology, ethanolamine is best appreciated as a nutrient for bacteria that supports growth. In our recent work (Anderson, et al. PLoS Pathog (2015, 11: e1005278, we demonstrated that Salmonella enterica serovar Typhimurium (Salmonella exploits ethanolamine signaling to adapt to distinct host environments to precisely coordinate expression of genes encoding metabolism and virulence, which ultimately enhances disease progression.

  20. Coordinated observations of the Martian ionosphere and induced magnetosphere with Mars Express and MAVEN

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    Andrews, D. J.; Brain, D. A.; Grebowsky, J. M.; Holmstrom, M.; Lillis, R. J.; Witasse, O. G.; Morgan, D. D.

    2013-12-01

    The NASA Mars Atmosphere and Volatile Evolution (MAVEN) mission is scheduled to launch in November 2013, and arrive in Mars orbit in September 2014. Meanwhile, the ESA Mars Express (MEX) mission is expected to be conducting its 10th year of scientific operations. The presence of both spacecraft simultaneously orbiting Mars, with complementary suites of scientific instruments, affords an excellent opportunity to study the Martian plasma environment in unprecedented detail. We present an overview of the coordinated measurements that are planned to be undertaken with MEX and MAVEN. The polar orbits of MEX (86 degree inclination, 300×10,000 km altitude, 7.5 h period) and MAVEN (76 degree inclination, 150×6200 km, 4.5 h period) will provide near-continuous measurements within the solar wind, along with frequent passages through the magnetosheath and ionosphere. The differing orbital parameters will provide a range of relative orbital configurations of the two spacecraft during the one-year MAVEN prime mission. A significant overlap exists between the scientific payloads of both missions, while each spacecraft also possesses unique instruments (e.g., the MAG vector magnetometer on MAVEN, and the MARSIS radar on MEX). Near continual monitoring of the solar wind bulk parameters will provide a new opportunity to understand the response of the Martian system to variable upstream conditions. Opportunities will also be present to cross-calibrate measurements made with different instruments on both spacecraft. During fortuitous close conjunctions, use of two spacecraft measurements will resolve spatial-temporal ambiguities in the dynamics of plasma boundaries and ionospheric structures. Two-spacecraft measurements will provide higher-cadence measurements of the numerous classes of anomalous or transient structures seen already at Mars, such as a large ionospheric flux ropes, outflow plumes and plasma density structures and boundaries. Throughout multiple ';deep-dip campaigns

  1. The R-Operon: A Model of Repetitive DNA-Organized Transcriptional Compartmentation of Eukaryotic Chromosomes for Coordinated Gene Expression

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    Tang, Shao-Jun

    2016-01-01

    In eukaryotic genomes, it is essential to coordinate the activity of genes that function together to fulfill the same biological processes. Genomic organization likely plays a key role in coordinating transcription of different genes. However, little is known about how co-regulated genes are organized in the cell nucleus and how the chromosomal organization facilitates the co-regulation of different genes. I propose that eukaryotic genomes are organized into repeat assembly (RA)-based structural domains (“R-operons”) in the nuclear space. R-operons result from the interaction of homologous DNA repeats. In an R-operon, genes in different loci of the linear genome are brought into spatial vicinity and co-regulated by the same pool of transcription factors. This type of large-scale chromosomal organization may provide a mechanism for functional compartmentation of chromosomes to facilitate the transcriptional coordination of gene expression. PMID:27110825

  2. Assembly of Two Transgenes in an Artificial Chromatin Domain Gives Highly Coordinated Expression in Tobacco

    NARCIS (Netherlands)

    Mlynárová, Ludmila; Loonen, Annelies; Mietkiewska, Elzbieta; Jansen, Ritsert C.; Nap, Jan-Peter

    2002-01-01

    The chromatin loop model predicts that genes within the same chromatin domain exhibit coordinated regulation. We here present the first direct experimental support for this model in plants. Two reporter genes, the E. coli β-glucuronidase gene and the firefly luciferase gene, driven by different prom

  3. Coordinate increase of telomerase activity and c-Myc expression in Helicobacter pylori-associated gastric diseases

    Institute of Scientific and Technical Information of China (English)

    Guo-Xin Zhang; Yan-Hong Gu; Zhi-Quan Zhao; Shun-Fu Xu; Hong-Ji Zhang; Hong-Di Wang; Bo Hao

    2004-01-01

    AIM: To detect the telomerase activity and c-Myc expression in gastric diseases and to examine the relation between these values and Helicobacter pylori (H pylori) as a risk factor for gastric cancer.METHODS: One hundred and seventy-one gastric samples were studied to detect telomerase activity using a telomerase polymerase chain reaction enzyme linked immunosorbent assay (PCR-ELTSA), and c-Myc expression using immunohistochemistry.RESULTS: The telomerase activity and c-Myc expression were higher in cancers (87.69% and 61.54%) than in noncancerous tissues. They were higher in chronic atrophic gastritis with severe intestinal metaplasia (52.38% and 47.62%) than in chronic atrophic gastritis with mild intestinal metaplasia (13.33% and 16.67%). Tn chronic atrophic gastritis with severe intestinal metaplasia, the telomerase activity and c-Myc expression were higher in cases with -H pylori infection (67.86% and 67.86%) than in those without infection (21.43%and 7.14%). c-Myc expression was higher in gastric cancer with H pylori infection (77.27%) than in that without infection (28.57%). The telomerase activity and c-Nyc expression were coordinately up-regulated in H pylori infected gastric cancer and chronic atrophic gastritis with severe intestinal metaplasia.CONCLUSION: H pylori infection may influence both telomerase activity and c-Myc expression in gastric diseases,especially in chronic atrophic gastritis.

  4. The effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated

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    Shahab Shubin W

    2012-08-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are a class of small RNAs that have been linked to a number of diseases including cancer. The potential application of miRNAs in the diagnostics and therapeutics of ovarian and other cancers is an area of intense interest. A current challenge is the inability to accurately predict the functional consequences of exogenous modulations in the levels of potentially therapeutic miRNAs. Methods In an initial effort to systematically address this issue, we conducted miRNA transfection experiments using two miRNAs (miR-7, miR-128. We monitored the consequent changes in global patterns of gene expression by microarray and quantitative (real-time polymerase chain reaction. Network analysis of the expression data was used to predict the consequence of each transfection on cellular function and these predictions were experimentally tested. Results While ~20% of the changes in expression patterns of hundreds to thousands of genes could be attributed to direct miRNA-mRNA interactions, the majority of the changes are indirect, involving the downstream consequences of miRNA-mediated changes in regulatory gene expression. The changes in gene expression induced by individual miRNAs are functionally coordinated but distinct between the two miRNAs. MiR-7 transfection into ovarian cancer cells induces changes in cell adhesion and other developmental networks previously associated with epithelial-mesenchymal transitions (EMT and other processes linked with metastasis. In contrast, miR-128 transfection induces changes in cell cycle control and other processes commonly linked with cellular replication. Conclusions The functionally coordinated patterns of gene expression displayed by different families of miRNAs have the potential to provide clinicians with a strategy to treat cancers from a systems rather than a single gene perspective.

  5. Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle

    OpenAIRE

    Chao, Lily C.; Zhang, Zidong; Pei, Liming; Saito, Tsugumichi; Tontonoz, Peter; Pilch, Paul F.

    2007-01-01

    Innervation is important for normal metabolism in skeletal muscle, including insulin-sensitive glucose uptake. However, the transcription factors that transduce signals from the neuromuscular junction to the nucleus and affect changes in metabolic gene expression are not well defined. We demonstrate here that the orphan nuclear receptor Nur77 is a regulator of gene expression linked to glucose utilization in muscle. In vivo, Nur77 is preferentially expressed in glycolytic compared to oxidativ...

  6. Clinical expression of developmental coordination disorder in a large Canadian family

    OpenAIRE

    Gaines, Robin; Collins, David; Boycott, Kym; Missiuna, Cheryl; DeLaat, Denise; Soucie, Helen

    2008-01-01

    Previous studies of the phenotype of developmental coordination disorder (DCD) have largely concentrated on population-based samples. The present study reports on an in-depth examination of a large Canadian family with eight children, after three children who were suspected to have DCD were referred for evaluation. Subsequently, five of the six children whose motor impairments could be measured, and the mother, met the diagnostic criteria for DCD as per the American Psychiatric Association’s ...

  7. Differential and coordinated expression of defensins and cytokines by gingival epithelial cells and dendritic cells in response to oral bacteria

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    Clark Edward A

    2010-07-01

    Full Text Available Abstract Background Epithelial cells and dendritic cells (DCs both initiate and contribute to innate immune responses to bacteria. However, much less is known about the coordinated regulation of innate immune responses between GECs and immune cells, particularly DCs in the oral cavity. The present study was conducted to investigate whether their responses are coordinated and are bacteria-specific in the oral cavity. Results The β-defensin antimicrobial peptides hBD1, hBD2 and hBD3 were expressed by immature DCs as well as gingival epithelial cells (GECs. HBD1, hBD2 and hBD3 are upregulated in DCs while hBD2 and hBD3 are upregulated in GECs in response to bacterial stimulation. Responses of both cell types were bacteria-specific, as demonstrated by distinctive profiles of hBDs mRNA expression and secreted cytokines and chemokines in response to cell wall preparations of various bacteria of different pathogenicity: Fusobacterium nucleatum, Actinomyces naeslundii and Porphyromonas gingivalis. The regulation of expression of hBD2, IL-8, CXCL2/GROβ and CCL-20/MIP3α by GECs was greatly enhanced by conditioned medium from bacterially activated DCs. This enhancement was primarily mediated via IL-1β, since induction was largely attenuated by IL-1 receptor antagonist. In addition, the defensins influence DCs by eliciting differential cytokine and chemokine secretion. HBD2 significantly induced IL-6, while hBD3 induced MCP-1 to approximately the same extent as LPS, suggesting a unique role in immune responses. Conclusions The results suggest that cytokines, chemokines and β-defensins are involved in interaction of these two cell types, and the responses are bacteria-specific. Differential and coordinated regulation between GECs and DCs may be important in regulation of innate immune homeostasis and response to pathogens in the oral cavity.

  8. Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic Ser/Thr kinase Pim-1.

    Directory of Open Access Journals (Sweden)

    Dig B Mahat

    Full Text Available The serine/threonine kinase Pim-1 directs selected signaling events that promote cell growth and survival and is overexpressed in diverse human cancers. Pim-1 expression is tightly controlled through multiple mechanisms, including regulation of mRNA turnover. In several cultured cell models, mitogenic stimulation rapidly induced and stabilized PIM1 mRNA, however, vigorous destabilization 4-6 hours later helped restore basal expression levels. Acceleration of PIM1 mRNA turnover coincided with accumulation of tristetraprolin (TTP, an mRNA-destabilizing protein that targets transcripts containing AU-rich elements. TTP binds PIM1 mRNA in cells, and suppresses its expression by accelerating mRNA decay. Reporter mRNA decay assays localized the TTP-regulated mRNA decay element to a discrete AU-rich sequence in the distal 3'-untranslated region that binds TTP. These data suggest that coordinated stimulation of TTP and PIM1 expression limits the magnitude and duration of PIM1 mRNA accumulation by accelerating its degradation as TTP protein levels increase. Consistent with this model, PIM1 and TTP mRNA levels were well correlated across selected human tissue panels, and PIM1 mRNA was induced to significantly higher levels in mitogen-stimulated fibroblasts from TTP-deficient mice. Together, these data support a model whereby induction of TTP mediates a negative feedback circuit to limit expression of selected mitogen-activated genes.

  9. Stochastic Coordinate Coding and Its Application for Drosophila Gene Expression Pattern Annotation

    OpenAIRE

    Lin, Binbin; Li, Qingyang; Sun, Qian; Lai, Ming-Jun; Davidson, Ian; Fan, Wei (David); Ye, Jieping

    2014-01-01

    \\textit{Drosophila melanogaster} has been established as a model organism for investigating the fundamental principles of developmental gene interactions. The gene expression patterns of \\textit{Drosophila melanogaster} can be documented as digital images, which are annotated with anatomical ontology terms to facilitate pattern discovery and comparison. The automated annotation of gene expression pattern images has received increasing attention due to the recent expansion of the image databas...

  10. Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc

    Science.gov (United States)

    Balasubramanian, Divya; Ohneck, Elizabeth A.; Chapman, Jessica; Weiss, Andy; Kim, Min Kyung; Reyes-Robles, Tamara; Zhong, Judy; Shaw, Lindsey N.; Lun, Desmond S.; Ueberheide, Beatrix; Shopsin, Bo

    2016-01-01

    ABSTRACT Staphylococcus aureus is a formidable human pathogen that uses secreted cytolytic factors to injure immune cells and promote infection of its host. Of these proteins, the bicomponent family of pore-forming leukocidins play critical roles in S. aureus pathogenesis. The regulatory mechanisms governing the expression of these toxins are incompletely defined. In this work, we performed a screen to identify transcriptional regulators involved in leukocidin expression in S. aureus strain USA300. We discovered that a metabolic sensor-regulator, RpiRc, is a potent and selective repressor of two leukocidins, LukED and LukSF-PV. Whole-genome transcriptomics, S. aureus exoprotein proteomics, and metabolomic analyses revealed that RpiRc influences the expression and production of disparate virulence factors. Additionally, RpiRc altered metabolic fluxes in the trichloroacetic acid cycle, glycolysis, and amino acid metabolism. Using mutational analyses, we confirmed and extended the observation that RpiRc signals through the accessory gene regulatory (Agr) quorum-sensing system in USA300. Specifically, RpiRc represses the rnaIII promoter, resulting in increased repressor of toxins (Rot) levels, which in turn negatively affect leukocidin expression. Inactivation of rpiRc phenocopied rot deletion and increased S. aureus killing of primary human polymorphonuclear leukocytes and the pathogenesis of bloodstream infection in vivo. Collectively, our results suggest that S. aureus senses metabolic shifts by RpiRc to differentially regulate the expression of leukocidins and to promote invasive disease. PMID:27329753

  11. A hyper-dynamic nature of bivalent promoter states underlies coordinated developmental gene expression modules

    OpenAIRE

    Shah, Akshay; Oldenburg, Anja; Collas, Philippe

    2014-01-01

    Background Chromatin remodeling is crucial for proper programing of developmental gene expression. Recent work provides a dynamic view of post-translational histone modifications during differentiation; however there is little insight on the evolution of combinatorial genome-wide patterns of chromatin marks, excluding an essential aspect of developmental gene regulation. Results We report here a 15-chromatin state Hidden Markov Model which describes changes in chromatin signatures in relation...

  12. Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to coordination defects in mice

    Science.gov (United States)

    Seeher, Sandra; Carlson, Bradley A.; Miniard, Angela C.; Wirth, Eva K.; Mahdi, Yassin; Hatfield, Dolph L.; Driscoll, Donna M.; Schweizer, Ulrich

    2014-01-01

    Selenocysteine Insertion Sequence (SECIS)-Binding Protein 2 (Secisbp2) binds to SECIS elements located in the 3′-untranslated region of eukaryotic selenoprotein mRNAs. It facilitates incorporation of the rare amino acid selenocysteine in response to UGA codons. Inactivation of Secisbp2 in hepatocytes greatly reduced selenoprotein levels. Neuron-specific inactivation of Secisbp2 (CamK-Cre; Secisbp2fl/fl) reduced cerebral expression of selenoproteins to a lesser extent than inactivation of tRNA[Ser]Sec. This allowed us to study the development of cortical parvalbumin-positive (PV+) interneurons, which are completely lost in tRNA[Ser]Sec mutants. PV+ interneuron density was reduced in the somatosensory cortex, hippocampus, and striatum. In situ-hybridization for Gad67 confirmed the reduction of GABAergic interneurons. Because of the obvious movement phenotype involving a broad, dystonic gait, we suspected basal ganglia dysfunction. Tyrosine hydroxylase expression was normal in substantia nigra neurons and their striatal terminals. However the densities of striatal PV+ and Gad67+ neurons were decreased by 65% and 49%, respectively. Likewise, the density of striatal cholinergic neurons was reduced by 68%. Our observations demonstrate that several classes of striatal interneurons depend on selenoprotein expression. These findings may offer an explanation for the movement phenotype of selenoprotein P-deficient mice and the movement disorder and mental retardation described in a patient carrying SECISBP2 mutations. PMID:24844465

  13. Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A

    Directory of Open Access Journals (Sweden)

    Zambonino-Infante Jose

    2011-02-01

    Full Text Available Abstract Background Vitamin A (VA has a key role in vertebrate morphogenesis, determining body patterning and growth through the control of cell proliferation and differentiation processes. VA regulates primary molecular pathways of those processes by the binding of its active metabolite (retinoic acid to two types of specific nuclear receptors: retinoic acid receptors (RARs and retinoid X receptors (RXRs, which promote transcription of downstream target genes. This process is well known in most of higher vertebrates; however, scarce information is available regarding fishes. Therefore, in order to gain further knowledge of fish larval development and its disruption by nutritional VA imbalance, the relative expression of some RARs and RXRs, as well as several genes involved in morpho- and skeletogenesis such as peroxisome proliferator-activated receptors (PPARA, PPARB and PPARG; retinol-binding protein (RBP; insulin-like growth factors I and II (IGF1 and IGF2, respectively; bone morphogenetic protein 2 (Bmp2; transforming growth factor β-1 (TGFB1; and genes encoding different extracellular matrix (ECM proteins such as matrix Gla protein (mgp, osteocalcin (bglap, osteopontin (SPP1, secreted protein acidic and rich in cysteine (SPARC and type I collagen α1 chain (COL1A1 have been studied in gilthead sea bream. Results During gilthead sea bream larval development, specific expression profiles for each gene were tightly regulated during fish morphogenesis and correlated with specific morphogenetic events and tissue development. Dietary hypervitaminosis A during early larval development disrupted the normal gene expression profile for genes involved in RA signalling (RARA, VA homeostasis (RBP and several genes encoding ECM proteins that are linked to skeletogenesis, such as bglap and mgp. Conclusions Present data reflects the specific gene expression patterns of several genes involved in larval fish RA signalling and skeletogenesis; and how

  14. Transgenic expression of an expanded (GCG)13 repeat PABPN1 leads to weakness and coordination defects in mice.

    Science.gov (United States)

    Dion, Patrick; Shanmugam, Vijayalakshmi; Gaspar, Claudia; Messaed, Christiane; Meijer, Inge; Toulouse, André; Laganiere, Janet; Roussel, Julie; Rochefort, Daniel; Laganiere, Simon; Allen, Carol; Karpati, George; Bouchard, Jean-Pierre; Brais, Bernard; Rouleau, Guy A

    2005-04-01

    Oculopharyngeal muscular dystrophy (OPMD) is a late-onset disorder caused by a (GCG)n trinucleotide repeat expansion in the poly(A) binding protein nuclear-1 (PABPN1) gene, which in turn leads to an expanded polyalanine tract in the protein. We generated transgenic mice expressing either the wild type or the expanded form of human PABPN1, and transgenic animals with the expanded form showed clear signs of abnormal limb clasping, muscle weakness, coordination deficits, and peripheral nerves alterations. Analysis of mitotic and postmitotic tissues in those transgenic animals revealed ubiquitinated PABPN1-positive intranuclear inclusions (INIs) in neuronal cells. This latter observation led us to test and confirm the presence of similar INIs in postmortem brain sections from an OPMD patient. Our results indicate that expanded PABPN1, presumably via the toxic effects of its polyalanine tract, can lead to inclusion formation and neurodegeneration in both the mouse and the human. PMID:15755680

  15. Deletion of a coordinate regulator of type 2 cytokine expression in mice

    Energy Technology Data Exchange (ETDEWEB)

    Mohrs, Markus; Blankespoor, Catherine M.; Wang, Zhi-En; Loots, Gaby G.; Hadeiba, Husein; Shinkai, Kanade; Rubin, Edward M.; Locksley, Richard M.

    2001-07-30

    Mechanisms underlying the differentiation of stable T helper subsets will be important in understanding how discrete types of immunity develop in response to different pathogens. An evolutionarily conserved {approx}400 base pair non-coding sequence in the IL-4/IL-13 intergenic region, designated CNS-1, was deleted in mice. The capacity to develop Th2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1-deleted mice maintained their capacity to produce IL-4. A T cell-specific element critical for optimal expression of type 2 cytokines may represent evolution of a regulatory sequence exploited by adaptive immunity.

  16. Successful Reconstruction of Tooth Germ with Cell Lines Requires Coordinated Gene Expressions from the Initiation Stage

    Directory of Open Access Journals (Sweden)

    Yasuhiro Tomooka

    2012-10-01

    Full Text Available Tooth morphogenesis is carried out by a series of reciprocal interactions between the epithelium and mesenchyme in embryonic germs. Previously clonal dental epithelial cell (epithelium of molar tooth germ (emtg lines were established from an embryonic germ. They were odontogenic when combined with a dental mesenchymal tissue, although the odontogenesis was quantitatively imperfect. To improve the microenvironment in the germs, freshly isolated dental epithelial cells were mixed with cells of lines, and germs were reconstructed in various combinations. The results demonstrated that successful tooth construction depends on the mixing ratio, the age of dental epithelial cells and the combination with cell lines. Analyses of gene expression in these germs suggest that some signal(s from dental epithelial cells makes emtg cells competent to communicate with mesenchymal cells and the epithelial and mesenchymal compartments are able to progress  odontogenesis from the initiation stage.

  17. Identification of coherent patterns in gene expression data using an efficient biclustering algorithm and parallel coordinate visualization

    Directory of Open Access Journals (Sweden)

    Siu Wan-Chi

    2008-04-01

    Full Text Available Abstract Background The DNA microarray technology allows the measurement of expression levels of thousands of genes under tens/hundreds of different conditions. In microarray data, genes with similar functions usually co-express under certain conditions only 1. Thus, biclustering which clusters genes and conditions simultaneously is preferred over the traditional clustering technique in discovering these coherent genes. Various biclustering algorithms have been developed using different bicluster formulations. Unfortunately, many useful formulations result in NP-complete problems. In this article, we investigate an efficient method for identifying a popular type of biclusters called additive model. Furthermore, parallel coordinate (PC plots are used for bicluster visualization and analysis. Results We develop a novel and efficient biclustering algorithm which can be regarded as a greedy version of an existing algorithm known as pCluster algorithm. By relaxing the constraint in homogeneity, the proposed algorithm has polynomial-time complexity in the worst case instead of exponential-time complexity as in the pCluster algorithm. Experiments on artificial datasets verify that our algorithm can identify both additive-related and multiplicative-related biclusters in the presence of overlap and noise. Biologically significant biclusters have been validated on the yeast cell-cycle expression dataset using Gene Ontology annotations. Comparative study shows that the proposed approach outperforms several existing biclustering algorithms. We also provide an interactive exploratory tool based on PC plot visualization for determining the parameters of our biclustering algorithm. Conclusion We have proposed a novel biclustering algorithm which works with PC plots for an interactive exploratory analysis of gene expression data. Experiments show that the biclustering algorithm is efficient and is capable of detecting co-regulated genes. The interactive

  18. Diatom acclimation to elevated CO2 via cAMP signalling and coordinated gene expression

    Science.gov (United States)

    Hennon, Gwenn M. M.; Ashworth, Justin; Groussman, Ryan D.; Berthiaume, Chris; Morales, Rhonda L.; Baliga, Nitin S.; Orellana, Mónica V.; Armbrust, E. V.

    2015-08-01

    Diatoms are responsible for ~40% of marine primary productivity, fuelling the oceanic carbon cycle and contributing to natural carbon sequestration in the deep ocean. Diatoms rely on energetically expensive carbon concentrating mechanisms (CCMs) to fix carbon efficiently at modern levels of CO2 (refs , , ). How diatoms may respond over the short and long term to rising atmospheric CO2 remains an open question. Here we use nitrate-limited chemostats to show that the model diatom Thalassiosira pseudonana rapidly responds to increasing CO2 by differentially expressing gene clusters that regulate transcription and chromosome folding, and subsequently reduces transcription of photosynthesis and respiration gene clusters under steady-state elevated CO2. These results suggest that exposure to elevated CO2 first causes a shift in regulation, and then a metabolic rearrangement. Genes in one CO2-responsive cluster included CCM and photorespiration genes that share a putative cAMP-responsive cis-regulatory sequence, implying these genes are co-regulated in response to CO2, with cAMP as an intermediate messenger. We verified cAMP-induced downregulation of CCM gene δ-CA3 in nutrient-replete diatom cultures by inhibiting the hydrolysis of cAMP. These results indicate an important role for cAMP in downregulating CCM and photorespiration genes under elevated CO2 and provide insights into mechanisms of diatom acclimation in response to climate change.

  19. Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration.

    Directory of Open Access Journals (Sweden)

    Melissa L Burke

    Full Text Available Determining the molecular events induced in the spleen during schistosome infection is an essential step in better understanding the immunopathogenesis of schistosomiasis and the mechanisms by which schistosomes modulate the host immune response. The present study defines the transcriptional and cellular events occurring in the murine spleen during the progression of Schistosoma japonicum infection. Additionally, we compared and contrasted these results with those we have previously reported for the liver. Microarray analysis combined with flow cytometry and histochemistry demonstrated that transcriptional changes occurring in the spleen were closely related to changes in cellular composition. Additionally, the presence of alternatively activated macrophages, as indicated by up-regulation of Chi3l3 and Chi3l4 and expansion of F4/80(+ macrophages, together with enhanced expression of the immunoregulatory genes ANXA1 and CAMP suggests the spleen may be an important site for the control of S. japonicum-induced immune responses. The most striking difference between the transcriptional profiles of the infected liver and spleen was the contrasting expression of chemokines and cell adhesion molecules. Lymphocyte chemokines, including the homeostatic chemokines CXCL13, CCL19 and CCL21, were significantly down-regulated in the spleen but up-regulated in the liver. Eosinophil (CCL11, CCL24, neutrophil (CXCL1 and monocyte (CXCL14, CCL12 chemokines and the cell adhesion molecules VCAM1, NCAM1, PECAM1 were up-regulated in the liver but unchanged in the spleen. Chemokines up-regulated in both organs were expressed at significantly higher levels in the liver. Co-ordinated expression of these genes probably contributes to the development of a chemotactic signalling gradient that promotes recruitment of effector cells to the liver, thereby facilitating the development of hepatic granulomas and fibrosis. Together these data provide, for the first time, a

  20. Integrative analysis of large scale expression profiles reveals core transcriptional response and coordination between multiple cellular processes in a cyanobacterium

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    Bhattacharyya-Pakrasi Maitrayee

    2010-08-01

    Full Text Available Abstract Background Cyanobacteria are the only known prokaryotes capable of oxygenic photosynthesis. They play significant roles in global biogeochemical cycles and carbon sequestration, and have recently been recognized as potential vehicles for production of renewable biofuels. Synechocystis sp. PCC 6803 has been extensively used as a model organism for cyanobacterial studies. DNA microarray studies in Synechocystis have shown varying degrees of transcriptome reprogramming under altered environmental conditions. However, it is not clear from published work how transcriptome reprogramming affects pre-existing networks of fine-tuned cellular processes. Results We have integrated 163 transcriptome data sets generated in response to numerous environmental and genetic perturbations in Synechocystis. Our analyses show that a large number of genes, defined as the core transcriptional response (CTR, are commonly regulated under most perturbations. The CTR contains nearly 12% of Synechocystis genes found on its chromosome. The majority of genes in the CTR are involved in photosynthesis, translation, energy metabolism and stress protection. Our results indicate that a large number of differentially regulated genes identified in most reported studies in Synechocystis under different perturbations are associated with the general stress response. We also find that a majority of genes in the CTR are coregulated with 25 regulatory genes. Some of these regulatory genes have been implicated in cellular responses to oxidative stress, suggesting that reactive oxygen species are involved in the regulation of the CTR. A Bayesian network, based on the regulation of various KEGG pathways determined from the expression patterns of their associated genes, has revealed new insights into the coordination between different cellular processes. Conclusion We provide here the first integrative analysis of transcriptome data sets generated in a cyanobacterium. This

  1. Rhizobacterial volatiles and photosynthesis-related signals coordinate MYB72 expression in Arabidopsis roots during onset of induced systemic resistance and iron-deficiency responses

    OpenAIRE

    2015-01-01

    In Arabidopsis roots, the transcription factor MYB72 plays a dual role in the onset of rhizobacteria-induced systemic resistance (ISR) and plant survival under conditions of limited iron availability. Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synthesis and excretion of iron-mobilizing phenolic compounds in the rhizosphere, a process that is involved in both iron acquisition and ISR signaling. Here, we show that volatile organic compounds (VO...

  2. Human Neonatal Peripheral Blood Leukocytes Demonstrate Pathogen-Specific Coordinate Expression of TLR2, TLR4/MD2 and MyD88 During Bacterial Infection In Vivo

    OpenAIRE

    Zhang, Jin-Ping; Yang, Yi(Department of Electrophysics, National Chiao-Tung University, Hsinchu, Taiwan, ROC); Levy, Ofer; Chen, Chao

    2010-01-01

    Toll-like receptors (TLRs) play important roles in infection. We have previously reported TLR2 is up-regulated in neonatal Gram-positive (G+) bacteremia whereas TLR4 is up-regulated in neonatal Gram-negative (G−) bacteremia. For functional signaling, TLR4 requires MD-2 and both TLR2 and TLR4 signal need MyD88. However, it is unknown whether newborns can enhance expression of MD-2 and MyD88 with bacterial infection in coordination with TLR expression. We characterized neonatal peripheral blood...

  3. MK-801 impairs cognitive coordination on a rotating arena (Carousel and contextual specificity of hippocampal immediate-early gene expression in a rat model of psychosis

    Directory of Open Access Journals (Sweden)

    Štěpán eKubík

    2014-03-01

    Full Text Available Flexible behavior in dynamic, real-world environments requires more than static spatial learning and memory. Discordant and unstable cues must be organized in coherent subsets to give rise to meaningful spatial representations. We model this form of cognitive coordination on a rotating arena - Carousel where arena- and room-bound spatial cues are dissociated. Hippocampal neuronal ensemble activity can repeatedly switch between multiple representations of such an environment. Injection of tetrodotoxin into one hippocampus prevents cognitive coordination during avoidance of a stationary room-defined place on the Carousel and increases coactivity of previously unrelated neurons in the uninjected hippocampus. Place avoidance on the Carousel is impaired after systemic administration of non-competitive NMDAr blockers (MK-801 used to model schizophrenia in animals and people. We tested if this effect is due to cognitive disorganization or other effect of NMDAr antagonism such as hyperlocomotion, spatial memory impairment, or general learning deficit. We also examined if the same dose of MK-801 alters patterns of immediate-early gene (IEG expression in the hippocampus. IEG expression is triggered in neuronal nuclei in a context-specific manner after behavioral exploration and it is used to map activity in neuronal populations. IEG expression is critical for maintenance of synaptic plasticity and memory consolidation. We show that the same dose of MK-801 that impairs spatial coordination of rats on the Carousel also eliminates contextual specificity of IEG expression in hippocampal CA1 ensembles. This effect is due to increased similarity between ensembles activated in different environments, consistent with the idea that it is caused by increased coactivity between neurons, which did not fire together before. Our data support the proposition of the Hypersynchrony theory that cognitive disorganization in psychosis is due to increased coactivity between

  4. Research on Expression Effect of Rhyme Coordination in Chinese Language%音韵协调在汉语语言中的表达效果研究

    Institute of Scientific and Technical Information of China (English)

    陈秀泉

    2012-01-01

    在汉语语言表达中,为了提高言语表达效果,应该重视音韵的协调,追求语言的形式美。音韵协调在汉语语言中,通过押韵、叠音、双声叠韵的形式,应用在诗歌语言、广告语言、短信语言和网络语言里,表达出音乐美和感染力、良好的宣传效应、幽默风趣的韵律、形象性和个性化色彩等不同效果,给人留下深刻的印象。%In Chinese language expression, attentions should be paid to rhyme coordination in pursuit of beauty of language form so as to enhance expression effect. In Chinese language, rhyme coordination in forms of rhymes, superposition tone,alliteration and assonance, is applied to poetic language, advertising language, short message language and network language, respectively expressing music beauty and appeal,good publicity,humorous rhymes,visual and personalized color, and contributin~ to an imr~r~iv~ off.or n;

  5. Identification of coherent patterns in gene expression data using an efficient biclustering algorithm and parallel coordinate visualization

    OpenAIRE

    Siu Wan-Chi; Law Ngai-Fong; Cheng Kin-On; Liew Alan

    2008-01-01

    Abstract Background The DNA microarray technology allows the measurement of expression levels of thousands of genes under tens/hundreds of different conditions. In microarray data, genes with similar functions usually co-express under certain conditions only 1. Thus, biclustering which clusters genes and conditions simultaneously is preferred over the traditional clustering technique in discovering these coherent genes. Various biclustering algorithms have been developed using different biclu...

  6. Coordinated Expression of Tristetraprolin Post-Transcriptionally Attenuates Mitogenic Induction of the Oncogenic Ser/Thr Kinase Pim-1

    OpenAIRE

    Dig B Mahat; Brennan-Laun, Sarah E.; Fialcowitz-White, Elizabeth J.; Kishor, Aparna; Ross, Christina R.; Pozharskaya, Tatyana; Rawn, J. David; Blackshear, Perry J.; Hassel, Bret A.; Wilson, Gerald M.

    2012-01-01

    The serine/threonine kinase Pim-1 directs selected signaling events that promote cell growth and survival and is overexpressed in diverse human cancers. Pim-1 expression is tightly controlled through multiple mechanisms, including regulation of mRNA turnover. In several cultured cell models, mitogenic stimulation rapidly induced and stabilized PIM1 mRNA, however, vigorous destabilization 4–6 hours later helped restore basal expression levels. Acceleration of PIM1 mRNA turnover coincided with ...

  7. An Improved Surface Simplification Method for Facial Expression Animation Based on Homogeneous Coordinate Transformation Matrix and Maximum Shape Operator

    OpenAIRE

    Juin-Ling Tseng

    2016-01-01

    Facial animation is one of the most popular 3D animation topics researched in recent years. However, when using facial animation, a 3D facial animation model has to be stored. This 3D facial animation model requires many triangles to accurately describe and demonstrate facial expression animation because the face often presents a number of different expressions. Consequently, the costs associated with facial animation have increased rapidly. In an effort to reduce storage costs, researchers h...

  8. DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression.

    Directory of Open Access Journals (Sweden)

    Yingjuan Qian

    Full Text Available P73, a member of the p53 family, plays a critical role in neural development and tumorigenesis. Due to the usage of two different promoters, p73 is expressed as two major isoforms, TAp73 and ΔNp73, often with opposing functions. Here, we reported that transcriptional factor DEC1, a target of the p53 family, exerts a distinct control of TAp73 and ΔNp73 expression. In particular, we showed that DEC1 was able to increase TAp73 expression via transcriptional activation of the TAp73 promoter. By contrast, Np73 transcription was inhibited by DEC1 via transcriptional repression of the ΔNp73 promoter. To further explore the underlying mechanism, we showed that DEC1 was unable to increase TAp73 expression in the absence of HDAC8, suggesting that HDAC8 is required for DEC1 to enhance TAp73 expression. Furthermore, we found that DEC1 was able to interact with HDAC8 and recruit HDAC8 to the TAp73, but not the ΔNp73, promoter. Together, our data provide evidence that DEC1 and HDAC8 in differentially regulate TAp73 and ΔNp73 expression, suggesting that this regulation may lay a foundation for a therapeutic strategy to enhance the chemosensitivity of tumor cells.

  9. Adventures in Coordinate Space

    Science.gov (United States)

    Chambers, J. E.

    2003-08-01

    A variety of coordinate systems have been used to study the N-body problem for cases involving a dominant central mass. These include the traditional Keplerian orbital elements and the canonical Delaunay variables, which both incorporate conserved quantities of the two-body problem. Recently, Cartesian coordinate systems have returned to favour with the rise of mixed-variable symplectic integrators, since these coordinates prove to be more efficient than using orbital elements. Three sets of canonical Cartesian coordinates are well known, each with its own advantages and disadvantages. Inertial coordinates (which include barycentric coordinates as a special case) are the simplest and easiest to implement. However, they suffer from the disadvantage that the motion of the central body must be calculated explicitly, leading to relatively large errors in general. Jacobi coordinates overcome this problem by replacing the coordinates and momenta of the central body with those of the system as a whole, so that momentum is conserved exactly. This leads to substantial improvements in accuracy, but has the disadvantage that every object is treated differently, and interactions between each pair of bodies are now expressed in a complicated manner involving the coordinates of many bodies. Canonical heliocentric coordinates (also known as democratic heliocentric coordinates) treat all bodies equally, and conserve the centre of mass motion, but at the cost of introducing momentum cross terms into the kinetic energy. This complicates the development of higher order symplectic integrators and symplectic correctors, as well as the development of methods used to resolve close encounters with the central body. Here I will re-examine the set of possible canonical Cartesian coordinate systems to determine if it is possible to (a) conserve the centre of mass motion, (b) treat all bodies equally, and (c) eliminate the momentum cross terms. I will demonstrate that this is indeed possible

  10. PDX1 and ISL1 differentially coordinate with epigenetic modifications to regulate insulin gene expression in varied glucose concentrations.

    Science.gov (United States)

    Wang, Weiping; Shi, Qiong; Guo, Ting; Yang, Zhe; Jia, Zhuqing; Chen, Ping; Zhou, Chunyan

    2016-06-15

    The mechanism of insulin gene transcription control in response to glucose concentration is poorly defined. The islet-restricted transcription factors PDX1 and ISL1 interact with BETA2, activating insulin gene expression. However, their contribution and hierarchical organization in insulin expression control based on glucose concentration remain unknown. We investigated PDX1 and ISL1 regulation of insulin gene expression in pancreatic β cells cultured in normal (5 mM/L) and high (25 mM/L) glucose conditions. ISL1 interacted with BETA2 to maintain basic insulin gene transcriptional activity under normal glucose. The ISL1-recruited cofactors SET9 and JMJD3 facilitated insulin gene histone modifications under normal glucose. In high-glucose concentrations, PDX1 formed a complex with BETA2 to enhance insulin gene expression. PDX1 also recruited SET9 and JMJD3 to promote the activation of histone modulation on the insulin promoter. This is the first evidence transcription factors orchestrate epigenetic modifications to control insulin gene expression based on glucose concentration. PMID:26994512

  11. A pair of transposons coordinately suppresses gene expression, independent of pathways mediated by siRNA in Antirrhinum.

    Science.gov (United States)

    Uchiyama, Takako; Hiura, Satoshi; Ebinuma, Izuru; Senda, Mineo; Mikami, Tetsuo; Martin, Cathie; Kishima, Yuji

    2013-01-01

    Our knowledge is limited regarding mechanisms by which transposable elements control host gene expression. Two Antirrhinum lines, HAM2 and HAM5, show different petal colors, pale-red and white, respectively, although these lines contain the same insertion of transposon Tam3 in the promoter region of the nivea (niv) locus encoding chalcone synthase. Among 1000 progeny from HAM5 grown under the preferred conditions for the Tam3 transposition, a few showed an intermediate petal color between HAM2 and HAM5. Transposon tagging using these progeny identified a causative insertion of Tam3 for the HAM5 type (white) petal color, which was found 1.6 kb downstream of the niv gene. Insertion of Tam3 at the position 1.6 kb downstream of niv alone showed nearly wildtype petal pigmentation, and the niv expression reduced by only 50%. Severe suppression of niv observed in HAM5 required interaction of two Tam3 copies on either side of the niv coding sequence. DNA methylation and small interfering RNAs (siRNAs) were not associated with the suppression of niv expression in HAM5. Insertion of a pair of transposons in close proximity can interfere with the expression of gene located between the two copies, and also provide evidence that this interference is not directly associated with pathways mediated by siRNAs. PMID:23190182

  12. MRP1 and glucosylceramide are coordinately over expressed and enriched in rafts during multidrug resistance acquisition in colon cancer cells

    NARCIS (Netherlands)

    Klappe, K; Hinrichs, JWJ; Kroesen, BJ; Sietsma, H; Kok, JW

    2004-01-01

    Previously we have described a novel multidrug-resistant cell line, HT29(col), which displayed over expression of the multidrug-resistance protein 1 (MRP1) and an altered sphingolipid composition, including enhanced levels of glucosylceramide (GlcCer; Kok JW, Veldman RJ, Klappe K, Koning H, Filipean

  13. Modular and Coordinated Expression of Immune System Regulatory and Signalling Components in the Developing and Adult Nervous System

    Directory of Open Access Journals (Sweden)

    Jimena Monzon-Sandoval

    2015-08-01

    Full Text Available During development, the nervous system is assembled and sculpted through a concerted series of neurodevelopmental events orchestrated by a complex genetic programme. While neural-specific gene expression plays a critical part in this process, in recent years, a number of immune-related signalling and regulatory components have also been shown to play key physiological roles in the developing and adult nervous system. While the involvement of individual immune-related signalling components in neural functions may reflect their ubiquitous character, it may also reflect a much wider, as yet undescribed, genetic network of immune–related molecules acting as an intrinsic component of the neural-specific regulatory machinery that ultimately shapes the nervous system. In order to gain insights into the scale and wider functional organization of immune-related genetic networks in the nervous system, we examined the large scale pattern of expression of these genes in the brain. Our results show a highly significant correlated expression and transcriptional clustering among immune-related genes in the developing and adult brain, and this correlation was the highest in the brain when compared to muscle, liver, kidney and endothelial cells. We experimentally tested the regulatory clustering of immune system genes by using microarray expression profiling in cultures of dissociated neurons stimulated with the pro-inflammatory cytokine TNF-alpha, and found a highly significant enrichment of immune system-related genes among the resulting differentially expressed genes. Our findings strongly suggest a coherent recruitment of entire immune-related genetic regulatory modules by the neural-specific genetic programme that shapes the nervous system.

  14. Grain feeding coordinately alters expression patterns of transcription factor and metabolic genes in subcutaneous adipose tissue of crossbred heifers.

    Science.gov (United States)

    Key, C N; Perkins, S D; Bratcher, C L; Kriese-Anderson, L A; Brandebourg, T D

    2013-06-01

    The ability to improve meat quality and production efficiency in cattle is limited by an inability to enhance marbling and simultaneously limit undesirable adipose tissue accretion. The objective of this study was to examine expression of regulatory genes in subcutaneous (SCF) adipose tissue of heifers in response to increasing days on feed (DOF) and finishing strategy. Crossbred heifers (n = 24) were allotted as follows: Group 1 = 0 d, Group 2 = 99 d on winter annual ryegrass (grass; Lolium multiflorum Lam.), Group 3 = 218 g on grass, Group 4 = 99 d on grass followed by 119 d on grain. Adipose tissue samples were collected at time of harvest and frozen. Carcass characteristics were measured 24 h postharvest. As expected, HCW (P grade increased (P grade (P meat quality whereas gene expression studies suggest several novel genes are associated with subcutaneous adipose tissue development in growing and finishing cattle. PMID:23482578

  15. Retina-derived POU domain factor 1 coordinates expression of genes relevant to renal and neuronal development.

    Science.gov (United States)

    Fiorino, Antonio; Manenti, Giacomo; Gamba, Beatrice; Bucci, Gabriele; De Cecco, Loris; Sardella, Michele; Buscemi, Giacomo; Ciceri, Sara; Radice, Maria T; Radice, Paolo; Perotti, Daniela

    2016-09-01

    Retina-derived POU domain Factor 1 (RPF-1), a member of POU transcription factor family, is encoded by POU6F2 gene, addressed by interstitial deletions at chromosome 7p14 in Wilms tumor (WT). Its expression has been detected in developing kidney and nervous system, suggesting an early role for this gene in regulating development of these organs. To investigate into its functions and determine its role in transcriptional regulation, we generated an inducible stable transfectant from HEK293 cells. RPF-1 showed nuclear localization, elevated stability, and transactivation of promoters featuring POU consensus sites, and led to reduced cell proliferation and in vivo tumor growth. By addressing the whole transcriptome regulated by its induction, we could detect a gross alteration of gene expression that is consistent with promoter occupancy predicted by genome-wide Chip-chip analysis. Comparison of bound regulatory regions with differentially expressed genes allowed identification of 217 candidate targets. Enrichment of divergent octamers in predicted regulatory regions revealed promiscuous binding to bipartite POUS and POUH consensus half-sites with intervening spacers. Gel-shift competition assay confirmed the specificity of RPF-1 binding to consensus motifs, and demonstrated that the Ser-rich region upstream of the POU domain is indispensable to achieve DNA-binding. Promoter-reporter activity addressing a few target genes indicated a dependence by RPF-1 on transcriptional response. In agreement with its expression in developing kidney and nervous system, the induced transcriptome appears to indicate a function for this protein in early renal differentiation and neuronal cell fate, providing a resource for understanding its role in the processes thereby regulated. PMID:27425396

  16. Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and structural segregation from GLUT4

    OpenAIRE

    1995-01-01

    Native rat adipocytes and the mouse adipocyte cell line, 3T3-L1, possess transport vesicles of apparently uniform composition and size which translocate the tissue-specific glucose transporter isoform, GLUT4, from an intracellular pool to the cell surface in an insulin- sensitive fashion. Caveolin, the presumed structural protein of caveolae, has also been proposed to function in vesicular transport. Thus, we studied the expression and subcellular distribution of caveolin in adipocytes. We fo...

  17. The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits

    OpenAIRE

    Zhong and, Shuping; Johnson, Deborah L.

    2009-01-01

    RNA polymerase (pol) III-dependent transcription is subject to stringent regulation by tumor suppressors and oncogenic proteins and enhanced RNA pol III transcription is essential for cellular transformation and tumorigenesis. Since the c-Jun N-terminal kinases (JNKs) display both oncogenic and tumor suppressor properties, the roles of these proteins in regulating RNA pol III transcription were examined. In both mouse and human cells, loss or reduction in JNK1 expression represses RNA pol III...

  18. Non-coordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny

    OpenAIRE

    Castro, Caitlin D.; Ohta, Yuko; Dooley, Helen; Flajnik, Martin F.

    2013-01-01

    Blimp-1 is the master regulator of plasma cell development, controlling genes such as J-chain and secretory Ig heavy chain. However, some mammalian plasma cells do not express J-chain, and mammalian B1 cells secrete “natural” IgM antibodies without upregulating Blimp-1. While these results have been controversial in mammalian systems, here we describe subsets of normally occurring Blimp-1- antibody secreting cells in nurse sharks, found in lymphoid tissues at all ontogenic stages. Sharks natu...

  19. Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing.

    Science.gov (United States)

    Decque, Adrien; Joffre, Olivier; Magalhaes, Joao G; Cossec, Jack-Christophe; Blecher-Gonen, Ronnie; Lapaquette, Pierre; Silvin, Aymeric; Manel, Nicolas; Joubert, Pierre-Emmanuel; Seeler, Jacob-Sebastian; Albert, Matthew L; Amit, Ido; Amigorena, Sebastian; Dejean, Anne

    2016-02-01

    Innate sensing of pathogens initiates inflammatory cytokine responses that need to be tightly controlled. We found here that after engagement of Toll-like receptors (TLRs) in myeloid cells, deficient sumoylation caused increased secretion of transcription factor NF-κB-dependent inflammatory cytokines and a massive type I interferon signature. In mice, diminished sumoylation conferred susceptibility to endotoxin shock and resistance to viral infection. Overproduction of several NF-κB-dependent inflammatory cytokines required expression of the type I interferon receptor, which identified type I interferon as a central sumoylation-controlled hub for inflammation. Mechanistically, the small ubiquitin-like modifier SUMO operated from a distal enhancer of the gene encoding interferon-β (Ifnb1) to silence both basal and stimulus-induced activity of the Ifnb1 promoter. Therefore, sumoylation restrained inflammation by silencing Ifnb1 expression and by strictly suppressing an unanticipated priming by type I interferons of the TLR-induced production of inflammatory cytokines. PMID:26657003

  20. Transcriptome analysis at four developmental stages of grape berry (Vitis vinifera cv. Shiraz provides insights into regulated and coordinated gene expression

    Directory of Open Access Journals (Sweden)

    Sweetman Crystal

    2012-12-01

    Full Text Available Abstract Background Vitis vinifera berry development is characterised by an initial phase where the fruit is small, hard and acidic, followed by a lag phase known as veraison. In the final phase, berries become larger, softer and sweeter and accumulate an array of organoleptic compounds. Since the physiological and biochemical makeup of grape berries at harvest has a profound impact on the characteristics of wine, there is great interest in characterising the molecular and biophysical changes that occur from flowering through veraison and ripening, including the coordination and temporal regulation of metabolic gene pathways. Advances in deep-sequencing technologies, combined with the availability of increasingly accurate V. vinifera genomic and transcriptomic data, have enabled us to carry out RNA-transcript expression analysis on a global scale at key points during berry development. Results A total of 162 million 100-base pair reads were generated from pooled Vitis vinifera (cv. Shiraz berries sampled at 3-weeks post-anthesis, 10- and 11-weeks post-anthesis (corresponding to early and late veraison and at 17-weeks post-anthesis (harvest. Mapping reads from each developmental stage (36-45 million onto the NCBI RefSeq transcriptome of 23,720 V. vinifera mRNAs revealed that at least 75% of these transcripts were detected in each sample. RNA-Seq analysis uncovered 4,185 transcripts that were significantly upregulated at a single developmental stage, including 161 transcription factors. Clustering transcripts according to distinct patterns of transcription revealed coordination in metabolic pathways such as organic acid, stilbene and terpenoid metabolism. From the phenylpropanoid/stilbene biosynthetic pathway at least 46 transcripts were upregulated in ripe berries when compared to veraison and immature berries, and 12 terpene synthases were predominantly detected only in a single sample. Quantitative real-time PCR was used to validate the

  1. Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides

    DEFF Research Database (Denmark)

    Almutairi, Mashal M; Park, Sung Ryeol; Rose, Simon;

    2015-01-01

    Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, in part because of the low propensity of these drugs to trigger the expression of resistance genes. A natural ketolide pikromycin and a related compound methymycin are produced by Streptomyces...... activation by ketolide antibiotics. The resistance genes and the induction mechanism remain fully functional when transferred to heterologous bacterial hosts. The anticipated wide use of ketolide antibiotics could promote horizontal transfer of these highly efficient resistance genes to pathogens. Taken...... together, these findings emphasized the need for surveillance of pikR1/pikR2-based bacterial resistance and the preemptive development of drugs that can remain effective against the ketolide-specific resistance mechanism....

  2. Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression

    Science.gov (United States)

    McDonald, Bradon R.; Takasuka, Taichi E.; Wendt-Pienkowski, Evelyn; Doering, Drew T.; Raffa, Kenneth F.; Fox, Brian G.; Currie, Cameron R.

    2016-01-01

    The evolution of cellulose degradation was a defining event in the history of life. Without efficient decomposition and recycling, dead plant biomass would quickly accumulate and become inaccessible to terrestrial food webs and the global carbon cycle. On land, the primary drivers of plant biomass deconstruction are fungi and bacteria in the soil or associated with herbivorous eukaryotes. While the ecological importance of plant-decomposing microbes is well established, little is known about the distribution or evolution of cellulolytic activity in any bacterial genus. Here we show that in Streptomyces, a genus of Actinobacteria abundant in soil and symbiotic niches, the ability to rapidly degrade cellulose is largely restricted to two clades of host-associated strains and is not a conserved characteristic of the Streptomyces genus or host-associated strains. Our comparative genomics identify that while plant biomass degrading genes (CAZy) are widespread in Streptomyces, key enzyme families are enriched in highly cellulolytic strains. Transcriptomic analyses demonstrate that cellulolytic strains express a suite of multi-domain CAZy enzymes that are coregulated by the CebR transcriptional regulator. Using targeted gene deletions, we verify the importance of a highly expressed cellulase (GH6 family cellobiohydrolase) and the CebR transcriptional repressor to the cellulolytic phenotype. Evolutionary analyses identify complex genomic modifications that drive plant biomass deconstruction in Streptomyces, including acquisition and selective retention of CAZy genes and transcriptional regulators. Our results suggest that host-associated niches have selected some symbiotic Streptomyces for increased cellulose degrading activity and that symbiotic bacteria are a rich biochemical and enzymatic resource for biotechnology. PMID:27276034

  3. Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression.

    Science.gov (United States)

    Book, Adam J; Lewin, Gina R; McDonald, Bradon R; Takasuka, Taichi E; Wendt-Pienkowski, Evelyn; Doering, Drew T; Suh, Steven; Raffa, Kenneth F; Fox, Brian G; Currie, Cameron R

    2016-06-01

    The evolution of cellulose degradation was a defining event in the history of life. Without efficient decomposition and recycling, dead plant biomass would quickly accumulate and become inaccessible to terrestrial food webs and the global carbon cycle. On land, the primary drivers of plant biomass deconstruction are fungi and bacteria in the soil or associated with herbivorous eukaryotes. While the ecological importance of plant-decomposing microbes is well established, little is known about the distribution or evolution of cellulolytic activity in any bacterial genus. Here we show that in Streptomyces, a genus of Actinobacteria abundant in soil and symbiotic niches, the ability to rapidly degrade cellulose is largely restricted to two clades of host-associated strains and is not a conserved characteristic of the Streptomyces genus or host-associated strains. Our comparative genomics identify that while plant biomass degrading genes (CAZy) are widespread in Streptomyces, key enzyme families are enriched in highly cellulolytic strains. Transcriptomic analyses demonstrate that cellulolytic strains express a suite of multi-domain CAZy enzymes that are coregulated by the CebR transcriptional regulator. Using targeted gene deletions, we verify the importance of a highly expressed cellulase (GH6 family cellobiohydrolase) and the CebR transcriptional repressor to the cellulolytic phenotype. Evolutionary analyses identify complex genomic modifications that drive plant biomass deconstruction in Streptomyces, including acquisition and selective retention of CAZy genes and transcriptional regulators. Our results suggest that host-associated niches have selected some symbiotic Streptomyces for increased cellulose degrading activity and that symbiotic bacteria are a rich biochemical and enzymatic resource for biotechnology. PMID:27276034

  4. Resistance to hemi-biotrophic F. graminearum infection is associated with coordinated and ordered expression of diverse defense signaling pathways.

    Directory of Open Access Journals (Sweden)

    Lina Ding

    Full Text Available Fusarium species cause serious diseases in cereal staple food crops such as wheat and maize. Currently, the mechanisms underlying resistance to Fusarium-caused diseases are still largely unknown. In the present study, we employed a combined proteomic and transcriptomic approach to investigate wheat genes responding to F. graminearum infection that causes Fusarium head blight (FHB. We found a total of 163 genes and 37 proteins that were induced by infection. These genes and proteins were associated with signaling pathways mediated by salicylic acid (SA, jasmonic acid (JA, ethylene (ET, calcium ions, phosphatidic acid (PA, as well as with reactive oxygen species (ROS production and scavenging, antimicrobial compound synthesis, detoxification, and cell wall fortification. We compared the time-course expression profiles between FHB-resistant Wangshuibai plants and susceptible Meh0106 mutant plants of a selected set of genes that are critical to the plants' resistance and defense reactions. A biphasic phenomenon was observed during the first 24 h after inoculation (hai in the resistant plants. The SA and Ca(2+ signaling pathways were activated within 6 hai followed by the JA mediated defense signaling activated around 12 hai. ET signaling was activated between these two phases. Genes for PA and ROS synthesis were induced during the SA and JA phases, respectively. The delayed activation of the SA defense pathway in the mutant was associated with its susceptibility. After F. graminearum infection, the endogenous contents of SA and JA in Wangshuibai and the mutant changed in a manner similar to the investigated genes corresponding to the individual pathways. A few genes for resistance-related cell modification and phytoalexin production were also identified. This study provided important clues for designing strategies to curb diseases caused by Fusarium.

  5. Rhizobacterial volatiles and photosynthesis-related signals coordinate MYB72 expression in Arabidopsis roots during onset of induced systemic resistance and iron-deficiency responses.

    Science.gov (United States)

    Zamioudis, Christos; Korteland, Jolanda; Van Pelt, Johan A; van Hamersveld, Muriël; Dombrowski, Nina; Bai, Yang; Hanson, Johannes; Van Verk, Marcel C; Ling, Hong-Qing; Schulze-Lefert, Paul; Pieterse, Corné M J

    2015-10-01

    In Arabidopsis roots, the transcription factor MYB72 plays a dual role in the onset of rhizobacteria-induced systemic resistance (ISR) and plant survival under conditions of limited iron availability. Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synthesis and excretion of iron-mobilizing phenolic compounds in the rhizosphere, a process that is involved in both iron acquisition and ISR signaling. Here, we show that volatile organic compounds (VOCs) from ISR-inducing Pseudomonas bacteria are important elicitors of MYB72. In response to VOC treatment, MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a manner that is dependent on FER-LIKE IRON DEFICIENCY TRANSCRIPTION FACTOR (FIT), indicating that MYB72 is an intrinsic part of the plant's iron-acquisition response that is typically activated upon iron starvation. However, VOC-induced MYB72 expression is activated independently of iron availability in the root vicinity. Moreover, rhizobacterial VOC-mediated induction of MYB72 requires photosynthesis-related signals, while iron deficiency in the rhizosphere activates MYB72 in the absence of shoot-derived signals. Together, these results show that the ISR- and iron acquisition-related transcription factor MYB72 in Arabidopsis roots is activated by rhizobacterial volatiles and photosynthesis-related signals, and enhances the iron-acquisition capacity of roots independently of the iron availability in the rhizosphere. This work highlights the role of MYB72 in plant processes by which root microbiota simultaneously stimulate systemic immunity and activate the iron-uptake machinery in their host plants. PMID:26307542

  6. The ACR11 encodes a novel type of chloroplastic ACT domain repeat protein that is coordinately expressed with GLN2 in Arabidopsis

    Directory of Open Access Journals (Sweden)

    Hsu Chih-Ping

    2011-08-01

    Full Text Available Abstract Background The ACT domain, named after bacterial aspartate kinase, chorismate mutase and TyrA (prephenate dehydrogenase, is a regulatory domain that serves as an amino acid-binding site in feedback-regulated amino acid metabolic enzymes. We have previously identified a novel type of ACT domain-containing protein family, the ACT domain repeat (ACR protein family, in Arabidopsis. Members of the ACR family, ACR1 to ACR8, contain four copies of the ACT domain that extend throughout the entire polypeptide. Here, we describe the identification of four novel ACT domain-containing proteins, namely ACR9 to ACR12, in Arabidopsis. The ACR9 and ACR10 proteins contain three copies of the ACT domain, whereas the ACR11 and ACR12 proteins have a putative transit peptide followed by two copies of the ACT domain. The functions of these plant ACR proteins are largely unknown. Results The ACR11 and ACR12 proteins are predicted to target to chloroplasts. We used protoplast transient expression assay to demonstrate that the Arabidopsis ACR11- and ACR12-green fluorescent fusion proteins are localized to the chloroplast. Analysis of an ACR11 promoter-β-glucuronidase (GUS fusion in transgenic Arabidopsis revealed that the GUS activity was mainly detected in mature leaves and sepals. Interestingly, coexpression analysis revealed that the GLN2, which encodes a chloroplastic glutamine synthetase, has the highest mutual rank in the coexpressed gene network connected to ACR11. We used RNA gel blot analysis to confirm that the expression pattern of ACR11 is similar to that of GLN2 in various organs from 6-week-old Arabidopsis. Moreover, the expression of ACR11 and GLN2 is highly co-regulated by sucrose and light/dark treatments in 2-week-old Arabidopsis seedlings. Conclusions This study reports the identification of four novel ACT domain repeat proteins, ACR9 to ACR12, in Arabidopsis. The ACR11 and ACR12 proteins are localized to the chloroplast, and the expression

  7. Practically Coordinating

    OpenAIRE

    Durfee, Edmund H.

    1999-01-01

    To coordinate, intelligent agents might need to know something about themselves, about each other, about how others view themselves and others, about how others think others view themselves and others, and so on. Taken to an extreme, the amount of knowledge an agent might possess to coordinate its interactions with others might outstrip the agent's limited reasoning capacity (its available time, memory, and so on). Much of the work in studying and building multiagent systems has thus been dev...

  8. Characterization of the TolB-Pal trans-envelope complex from Xylella fastidiosa reveals a dynamic and coordinated protein expression profile during the biofilm development process.

    Science.gov (United States)

    Santos, Clelton A; Janissen, Richard; Toledo, Marcelo A S; Beloti, Lilian L; Azzoni, Adriano R; Cotta, Monica A; Souza, Anete P

    2015-10-01

    The intriguing roles of the bacterial Tol-Pal trans-envelope protein complex range from maintenance of cell envelope integrity to potential participation in the process of cell division. In this study, we report the characterization of the XfTolB and XfPal proteins of the Tol-Pal complex of Xylella fastidiosa. X. fastidiosa is a major plant pathogen that forms biofilms inside xylem vessels, triggering the development of diseases in important cultivable plants around the word. Based on functional complementation experiments in Escherichia coli tolB and pal mutant strains, we confirmed the role of xftolB and xfpal in outer membrane integrity. In addition, we observed a dynamic and coordinated protein expression profile during the X. fastidiosa biofilm development process. Using small-angle X-ray scattering (SAXS), the low-resolution structure of the isolated XfTolB-XfPal complex in solution was solved for the first time. Finally, the localization of the XfTolB and XfPal polar ends was visualized via immunofluorescence labeling in vivo during bacterial cell growth. Our results highlight the major role of the components of the cell envelope, particularly the TolB-Pal complex, during the different phases of bacterial biofilm development. PMID:26049080

  9. Archimedes' principle in general coordinates

    International Nuclear Information System (INIS)

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is applied in Schwarzschild coordinates and in rotating coordinates. Using Schwarzschild coordinates for the case of a spherical mass suspended within a perfect fluid leads to the familiar expression of Archimedes' principle. Using rotating coordinates produces an expression for a centrifugal buoyancy force that agrees with accepted theory. It is then argued that Archimedes' principle ought to be applicable to non-gravitational phenomena, as well. Conservation of the energy-momentum tensor is then applied to electromagnetic phenomena. It is shown that a charged body submerged in a charged medium experiences a buoyancy force in accordance with an electromagnetic analogue of Archimedes' principle.

  10. FORMATION OF ARCHITECTURE OF CHRISTIANITY AND ISLAM AS AN EXPRESSION OF THE CONCEPT OF THE COORDINATES SYSTEM IN SPIRITUALLY-REAL SPACE

    Directory of Open Access Journals (Sweden)

    I. A. Ibragimov

    2009-04-01

    Full Text Available Principle of formation of religious architecture of Islam and Christianity are considered subject to concept of the coordinates system in spiritually-real space. The integrants of this conception such as reference point of coordinates system, direction of conduction of a prayer, point of conduction of a prayer are examined.

  11. FORMATION OF ARCHITECTURE OF CHRISTIANITY AND ISLAM AS AN EXPRESSION OF THE CONCEPT OF THE COORDINATES SYSTEM IN SPIRITUALLY-REAL SPACE

    OpenAIRE

    Ibragimov, I. A.

    2009-01-01

    Principle of formation of religious architecture of Islam and Christianity are considered subject to concept of the coordinates system in spiritually-real space. The integrants of this conception such as reference point of coordinates system, direction of conduction of a prayer, point of conduction of a prayer are examined.

  12. Identification of network topological units coordinating the global expression response to glucose in Bacillus subtilis and its comparison to Escherichia coli

    Directory of Open Access Journals (Sweden)

    Gutiérrez-Ríos Rosa

    2009-08-01

    Full Text Available Abstract Background Glucose is the preferred carbon and energy source for Bacillus subtilis and Escherichia coli. A complex regulatory network coordinates gene expression, transport and enzymatic activities, in response to the presence of this sugar. We present a comparison of the cellular response to glucose in these two model organisms, using an approach combining global transcriptome and regulatory network analyses. Results Transcriptome data from strains grown in Luria-Bertani medium (LB or LB+glucose (LB+G were analyzed, in order to identify differentially transcribed genes in B. subtilis. We detected 503 genes in B. subtilis that change their relative transcript levels in the presence of glucose. A similar previous study identified 380 genes in E. coli, which respond to glucose. Catabolic repression was detected in the case of transport and metabolic interconversion activities for both bacteria in LB+G. We detected an increased capacity for de novo synthesis of nucleotides, amino acids and proteins. A comparison between orthologous genes revealed that global regulatory functions such as transcription, translation, replication and genes relating to the central carbon metabolism, presented similar changes in their levels of expression. An analysis of the regulatory network of a subset of genes in both organisms revealed that the set of regulatory proteins responsible for similar physiological responses observed in the transcriptome analysis are not orthologous. An example of this observation is that of transcription factors mediating catabolic repression for most of the genes that displayed reduced transcript levels in the case of both organisms. In terms of topological functional units in both these bacteria, we found interconnected modules that cluster together genes relating to heat shock, respiratory functions, carbon and peroxide metabolism. Interestingly, B. subtilis functions not found in E. coli, such as sporulation and competence

  13. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    Overview From a technical perspective, CMS has been in “beam operation” state since 6th November. The detector is fully closed with all components operational and the magnetic field is normally at the nominal 3.8T. The UXC cavern is normally closed with the radiation veto set. Access to UXC is now only possible during downtimes of LHC. Such accesses must be carefully planned, documented and carried out in agreement with CMS Technical Coordination, Experimental Area Management, LHC programme coordination and the CCC. Material flow in and out of UXC is now strictly controlled. Access to USC remains possible at any time, although, for safety reasons, it is necessary to register with the shift crew in the control room before going down.It is obligatory for all material leaving UXC to pass through the underground buffer zone for RP scanning, database entry and appropriate labeling for traceability. Technical coordination (notably Stephane Bally and Christoph Schaefer), the shift crew and run ...

  14. Coordinated unbundling

    DEFF Research Database (Denmark)

    Timmermans, Bram; Zabala-Iturriagagoitia, Jon Mikel

    2013-01-01

    not focused on the role this policy instrument can play in the promotion of (knowledge-intensive) entrepreneurship. This paper investigates this link in more detail and introduces the concept of coordinated unbundling as a strategy that can facilitate this purpose. We also present a framework on how......Public procurement for innovation is a matter of using public demand to trigger innovation. Empirical studies have demonstrated that demand-based policy instruments can be considered to be a powerful tool in stimulating innovative processes among existing firms; however, the existing literature has...

  15. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    2010-01-01

    Operational Experience At the end of the first full-year running period of LHC, CMS is established as a reliable, robust and mature experiment. In particular common systems and infrastructure faults accounted for <0.6 % CMS downtime during LHC pp physics. Technical operation throughout the entire year was rather smooth, the main faults requiring UXC access being sub-detector power systems and rack-cooling turbines. All such problems were corrected during scheduled technical stops, in the shadow of tunnel access needed by the LHC, or in negotiated accesses or access extensions. Nevertheless, the number of necessary accesses to the UXC averaged more than one per week and the technical stops were inevitably packed with work packages, typically 30 being executed within a few days, placing a high load on the coordination and area management teams. It is an appropriate moment for CMS Technical Coordination to thank all those in many CERN departments and in the Collaboration, who were involved in CMS techni...

  16. RNA-seq Transcriptional Profiling of an Arbuscular Mycorrhiza Provides Insights into Regulated and Coordinated Gene Expression in Lotus japonicus and Rhizophagus irregularis

    OpenAIRE

    Handa, Yoshihiro; Nishide, Hiroyo; Takeda, Naoya; Suzuki, Yutaka; Kawaguchi, Masayoshi; SAITO, KATSUHARU

    2015-01-01

    Gene expression during arbuscular mycorrhizal development is highly orchestrated in both plants and arbuscular mycorrhizal fungi. To elucidate the gene expression profiles of the symbiotic association, we performed a digital gene expression analysis of Lotus japonicus and Rhizophagus irregularis using a HiSeq 2000 next-generation sequencer with a Cufflinks assembly and de novo transcriptome assembly. There were 3,641 genes differentially expressed during arbuscular mycorrhizal development in ...

  17. Coordination Capacity

    CERN Document Server

    Cuff, Paul; Cover, Thomas

    2009-01-01

    We develop elements of a theory of cooperation and coordination in networks. Rather than considering a communication network as a means of distributing information, or of reconstructing random processes at remote nodes, we ask what dependence can be established among the nodes given the communication constraints. Specifically, in a network with communication rates between the nodes, we ask what is the set of all achievable joint distributions p(x1, ..., xm) of actions at the nodes on the network. Several networks are solved, including arbitrarily large cascade networks. Distributed cooperation can be the solution to many problems such as distributed games, distributed control, and establishing mutual information bounds on the influence of one part of a physical system on another.

  18. MK-801 impairs cognitive coordination on a rotating arena (Carousel) and contextual specificity of hippocampal immediate-early gene expression in a rat model of psychosis

    Czech Academy of Sciences Publication Activity Database

    Kubík, Štěpán; Buchtová, Helena; Valeš, Karel; Stuchlík, Aleš

    2014-01-01

    Roč. 8, Mar 12 (2014), s. 75. ISSN 1662-5153 R&D Projects: GA ČR(CZ) GPP303/10/P191 Grant ostatní: EC(XE) PIR06-GA/2009-256581 Institutional support: RVO:67985823 Keywords : cognitive coordination * learning * dizocilpine * animal model * psychosis Subject RIV: FH - Neurology Impact factor: 3.270, year: 2014

  19. RUN COORDINATION

    CERN Multimedia

    C. Delaere

    2013-01-01

    Since the LHC ceased operations in February, a lot has been going on at Point 5, and Run Coordination continues to monitor closely the advance of maintenance and upgrade activities. In the last months, the Pixel detector was extracted and is now stored in the pixel lab in SX5; the beam pipe has been removed and ME1/1 removal has started. We regained access to the vactank and some work on the RBX of HB has started. Since mid-June, electricity and cooling are back in S1 and S2, allowing us to turn equipment back on, at least during the day. 24/7 shifts are not foreseen in the next weeks, and safety tours are mandatory to keep equipment on overnight, but re-commissioning activities are slowly being resumed. Given the (slight) delays accumulated in LS1, it was decided to merge the two global runs initially foreseen into a single exercise during the week of 4 November 2013. The aim of the global run is to check that we can run (parts of) CMS after several months switched off, with the new VME PCs installed, th...

  20. RUN COORDINATION

    CERN Multimedia

    Christophe Delaere

    2013-01-01

    The focus of Run Coordination during LS1 is to monitor closely the advance of maintenance and upgrade activities, to smooth interactions between subsystems and to ensure that all are ready in time to resume operations in 2015 with a fully calibrated and understood detector. After electricity and cooling were restored to all equipment, at about the time of the last CMS week, recommissioning activities were resumed for all subsystems. On 7 October, DCS shifts began 24/7 to allow subsystems to remain on to facilitate operations. That culminated with the Global Run in November (GriN), which   took place as scheduled during the week of 4 November. The GriN has been the first centrally managed operation since the beginning of LS1, and involved all subdetectors but the Pixel Tracker presently in a lab upstairs. All nights were therefore dedicated to long stable runs with as many subdetectors as possible. Among the many achievements in that week, three items may be highlighted. First, the Strip...

  1. MK-801 Impairs Cognitive Coordination on a Rotating Arena (Carousel) and Contextual Specificity of Hippocampal Immediate-Early Gene Expression in a Rat Model of Psychosis

    OpenAIRE

    Kubík, Štěpán; Buchtová, Helena; Valeš, Karel; Stuchlík, Aleš

    2014-01-01

    Flexible behavior in dynamic, real-world environments requires more than static spatial learning and memory. Discordant and unstable cues must be organized in coherent subsets to give rise to meaningful spatial representations. We model this form of cognitive coordination on a rotating arena – Carousel where arena- and room-bound spatial cues are dissociated. Hippocampal neuronal ensemble activity can repeatedly switch between multiple representations of such an environment. Injection of tetr...

  2. MK-801 impairs cognitive coordination on a rotating arena (Carousel) and contextual specificity of hippocampal immediate-early gene expression in a rat model of psychosis

    OpenAIRE

    Štěpán eKubík; Helena eBuchtová; Karel eValeš; Aleš eStuchlík

    2014-01-01

    Flexible behavior in dynamic, real-world environments requires more than static spatial learning and memory. Discordant and unstable cues must be organized in coherent subsets to give rise to meaningful spatial representations. We model this form of cognitive coordination on a rotating arena - Carousel where arena- and room-bound spatial cues are dissociated. Hippocampal neuronal ensemble activity can repeatedly switch between multiple representations of such an environment. Injection of tetr...

  3. pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma

    DEFF Research Database (Denmark)

    Struckmann, K; Mertz, Kd; Steu, S; Storz, M; Staller, P; Krek, W; Schraml, P; Moch, H

    2008-01-01

    Loss of pVHL function, characteristic for clear-cell renal cell carcinoma (ccRCC), causes increased expression of CXCR4 chemokine receptor, which triggers expression of metastasis-associated MMP2/MMP9 in different human cancers. The impact of pVHL on MMP2/MMP9 expression and their relationship to...... CXCR4 and its ligand CXCL12 in ccRCC is unclear. By using reverse transcription PCR, immunofluorescence and immunohistochemistry, strong mRNA and protein expression of CXCR4, CXCL12, MMP2, MMP9 and MMP inhibitors TIMP1 and TIMP2 was found in VHL-null 786-O ccRCC cells. Loss of CXCR4/CXCL12 expression...... after restoration of VHL function in these cells was accompanied by a significant reduction of MMP2 and MMP9 expression, whereas neither TIMP1 nor TIMP2 expression was affected. Using real-time PCR analysis, higher MMP2 (p = 0.0134) and MMP9 (p = 0.067) mRNA expression levels were detected in primary cc...

  4. Global coordination: weighted voting

    Directory of Open Access Journals (Sweden)

    Jan-Erik Lane

    2014-03-01

    Full Text Available In order to halt the depletion of global ecological capital, a number of different kinds of meetings between Governments of countries in the world has been scheduled. The need for global coordination of environmental policies has become ever more obvious, supported by more and more evidence of the running down of ecological capital. But there are no formal or binding arrangements in sight, as global environmental coordination suffers from high transaction costs (qualitative voting. The CO2 equivalent emissions, resulting in global warming, are driven by the unstoppable economic expansion in the global market economy, employing mainly fossil fuel generated energy, although at the same time lifting sharply the GDP per capita of several emerging countries. Only global environmental coordination on the successful model of the World Band and the IMF (quantitative voting can stem the rising emissions numbers and stop further environmental degradation. However, the system of weighted voting in the WB and the IMF must be reformed by reducing the excessive voting power disparities, for instance by reducing all member country votes by the cube root expression.

  5. Polycations XX: New Monodentate Cationic Ligands and Their Coordination with Ruthenium for the Construction of Complexes Expressing Enhanced Interaction with DNA

    Directory of Open Access Journals (Sweden)

    Leslie Babukutty

    2012-01-01

    Full Text Available Prior investigations from this laboratory concerned with the preparation of new types of organic cations for a variety of biological and nonbiological applications have been extended to the preparation of cation-bearing ligands with nitrogen coordinating sites for use in complexation reactions with ruthenium cores. The syntheses of new cationic ligands as well as ruthenium complexes bearing them are reported here. The introduction of these new types of ligands is intended to provide to the complexes an enhanced ability to interact with DNA, and thereby to have the potential to be enhanced antitumor agents. Preliminary observations of their interactions with DNA are presented.

  6. Expression

    Directory of Open Access Journals (Sweden)

    Wang-Xia Wang

    2014-02-01

    Full Text Available The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs, sharing a 5′ AGCAGC sequence. These miRNAs have overlapping targets. In order to characterize the expression of miR-15/107 family miRNAs, we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members, and other selected miRNAs, in 11 human tissues obtained at autopsy including the cerebral cortex, frontal cortex, primary visual cortex, thalamus, heart, lung, liver, kidney, spleen, stomach and skeletal muscle. miR-103, miR-195 and miR-497 were expressed at similar levels across various tissues, whereas miR-107 is enriched in brain samples. We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations (enriched for cortical neurons, astrocytes and microglia, respectively. In primary cultures of rat brain cells, several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system (CNS. In addition to mature miRNAs, we also examined the expression of precursors (pri-miRNAs. Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors. In summary, we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.

  7. Histone Deacetylases and NF-kB Signaling Coordinate Expression of CX3CL1 in Epithelial Cells in Response to Microbial Challenge by Suppressing miR-424 and miR-503

    Science.gov (United States)

    Zhou, Rui; Gong, Ai-Yu; Chen, Dongqing; Miller, Ryan E.; Eischeid, Alex N.; Chen, Xian-Ming

    2013-01-01

    The NF-kB pathway is key to epithelial immune defense and has been implicated in secretion of antimicrobial peptides, release of cytokines/chemokines to mobilize immune effector cells, and activation of adaptive immunity. The expression of many inflammatory genes following infection involves the remodeling of the chromatin structure. We reported here that histone deacetylases (HDACs) and NF-kB signaling coordinate expression of CX3CL1 in epithelial cells following Cryptosporidium parvum infection. Upregulation of CX3CL1 was detected in cultured human biliary epithelial cells following infection. Expression of miR-424 and miR-503 was downregulated, and was involved in the induction of CX3CL1 in infected cells. C. parvum infection suppressed transcription of the mir-424-503 gene in a NF-kB- and HDAC-dependent manner. Increased promoter recruitment of NF-kB p50 and HDACs, and decreased promoter H3 acetylation associated with the mir-424-503 gene were observed in infected cells. Upregulation of CX3CL1 in biliary epithelial cells and increased infiltration of CX3CR1+ cells were detected during C. parvum infection in vivo. Induction of CX3CL1 and downregulation of miR-424 and miR-503 were also detected in epithelial cells in response to LPS stimulation. The above results indicate that HDACs and NF-kB signaling coordinate epithelial expression of CX3CL1 to promote mucosal antimicrobial defense through suppression of the mir-424-503 gene. PMID:23724129

  8. Histone deacetylases and NF-kB signaling coordinate expression of CX3CL1 in epithelial cells in response to microbial challenge by suppressing miR-424 and miR-503.

    Directory of Open Access Journals (Sweden)

    Rui Zhou

    Full Text Available The NF-kB pathway is key to epithelial immune defense and has been implicated in secretion of antimicrobial peptides, release of cytokines/chemokines to mobilize immune effector cells, and activation of adaptive immunity. The expression of many inflammatory genes following infection involves the remodeling of the chromatin structure. We reported here that histone deacetylases (HDACs and NF-kB signaling coordinate expression of CX3CL1 in epithelial cells following Cryptosporidium parvum infection. Upregulation of CX3CL1 was detected in cultured human biliary epithelial cells following infection. Expression of miR-424 and miR-503 was downregulated, and was involved in the induction of CX3CL1 in infected cells. C. parvum infection suppressed transcription of the mir-424-503 gene in a NF-kB- and HDAC-dependent manner. Increased promoter recruitment of NF-kB p50 and HDACs, and decreased promoter H3 acetylation associated with the mir-424-503 gene were observed in infected cells. Upregulation of CX3CL1 in biliary epithelial cells and increased infiltration of CX3CR1(+ cells were detected during C. parvum infection in vivo. Induction of CX3CL1 and downregulation of miR-424 and miR-503 were also detected in epithelial cells in response to LPS stimulation. The above results indicate that HDACs and NF-kB signaling coordinate epithelial expression of CX3CL1 to promote mucosal antimicrobial defense through suppression of the mir-424-503 gene.

  9. Archimedes' Principle in General Coordinates

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is…

  10. Multiple expression of molecular information: enforced generation of different supramolecular inorganic architectures by processing of the same ligand information through specific coordination algorithms

    Science.gov (United States)

    Funeriu; Lehn; Fromm; Fenske

    2000-06-16

    The multisubunit ligand 2 combines two complexation substructures known to undergo, with specific metal ions, distinct self-assembly processes to form a double-helical and a grid-type structure, respectively. The binding information contained in this molecular strand may be expected to generate, in a strictly predetermined and univocal fashion, two different, well-defined output inorganic architectures depending on the set of metal ions, that is, on the coordination algorithm used. Indeed, as predicted, the self-assembly of 2 with eight CuII and four CuI yields the intertwined structure D1. It results from a crossover of the two assembly subprograms and has been fully characterized by crystal structure determination. On the other hand, when the instructions of strand 2 are read out with a set of eight CuI and four MII (M = Fe, Co, Ni, Cu) ions, the architectures C1-C4, resulting from a linear combination of the two subprograms, are obtained, as indicated by the available physico-chemical and spectral data. Redox interconversion of D1 and C4 has been achieved. These results indicate that the same molecular information may yield different output structures depending on how it is processed, that is, depending on the interactional (coordination) algorithm used to read it. They have wide implications for the design and implementation of programmed chemical systems, pointing towards multiprocessing capacity, in a one code/ several outputs scheme, of potential significance for molecular computation processes and possibly even with respect to information processing in biology. PMID:10926214

  11. IL-17A promotes the migration and invasiveness of cervical cancer cells by coordinately activating MMPs expression via the p38/NF-κB signal pathway.

    Directory of Open Access Journals (Sweden)

    Minjuan Feng

    Full Text Available IL-17A plays an important role in many inflammatory diseases and cancers. We aimed to examine the effect of IL-17A on the invasion of cervical cancer cells and study its related mechanisms.Wound healing and matrigel transwell assays were used to examine the effect of IL-17A on cervical cancer cell migration and invasion by a panel of cervical cancer cell lines. The levels of matrix metalloproteinases (MMPs and tissue inhibitor of metalloproteinases (TIMPs were investigated using western blotting. The activity of p38 and nuclear factor-kappa B (NF-κB signal pathway was detected too.Here, we showed that IL-17A could promote the migration and invasion of cervical cancer cells. Further molecular analysis showed that IL-17A could up-regulate the expressions and activities of MMP2 and MMP9, and down-regulate the expressions of TIMP-1 and TIMP-2. Furthermore, IL-17A also activates p38 signal pathway and increased p50 and p65 nuclear expression. In addition, treatment of cervical cancer cells with the pharmacological p38/NF-κB signal pathway inhibitors, SB203580 and PDTC, potently restored the roles of invasion and upregulation of MMPs induced by IL-17A.IL-17A could promote the migration and invasion of cervical cancer cell via up-regulating MMP2 and MMP9 expression, and down-regulating TIMP-1 and TIMP-2 expression via p38/NF-κB signal pathway. IL-17A may be a potential target to improve the prognosis for patients with cervical cancer.

  12. Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients

    DEFF Research Database (Denmark)

    Suetta, Charlotte; Suetta, Charlotte Arneboe; Clemmensen, Christoffer;

    2010-01-01

    Hypertrophy of developing skeletal muscle involves stimulation by insulin-like growth factor-I (IGF-I), however, the role of IGF-I in adult muscle is less clarified. In the present study, the mRNA splice variants of IGF-I (IGF-IEa and MGF) and the changes in muscle fiber cross sectional area after...... in addition induces marked increases in the expression of IGF-I splice variants, supporting the idea that IGF-I is involved in regulating muscle hypertrophy.......-operated-side served as a within subject control. Muscle biopsies were obtained from the vastus lateralis of both limbs at +2d post-operative (baseline), at 5weeks and 12weeks post-surgery to analyze for changes in type 1 and type 2 muscle fiber area. Changes in expression levels of IGF-I mRNA isoforms were determined...

  13. Administration of Lactobacillus evokes coordinated changes in the intestinal expression profile of genes regulating energy homeostasis and immune phenotype in mice.

    Science.gov (United States)

    Nerstedt, Annika; Nilsson, Elisabeth C; Ohlson, Kajsa; Håkansson, Janet; Thomas Svensson, L; Löwenadler, Björn; Svensson, Ulla K; Mahlapuu, Margit

    2007-06-01

    Lactic acid bacteria are probiotics widely used in functional food products, with a variety of beneficial effects reported. Recently, intense research has been carried out to provide insight into the mechanism of the action of probiotic bacteria. We have used gene array technology to map the pattern of changes in the global gene expression profile of the host caused by Lactobacillus administration. Affymetrix microarrays were applied to comparatively characterize differences in gene transcription in the distal ileum of normal microflora (NMF) and germ-free (GF) mice evoked by oral administration of two Lactobacillus strains used in fermented dairy products today - Lactobacillus paracasei ssp. paracasei F19 (L. F19) or Lactobacillus acidophilus NCFB 1748. We show that feeding either of the two strains caused very similar effects on the transcriptional profile of the host. Both L. F19 and L. acidophilus NCFB 1748 evoked a complex response in the gut, reflected by differential regulation of a number of genes involved in essential physiological functions such as immune response, regulation of energy homeostasis and host defence. Notably, the changes in intestinal gene expression caused by Lactobacillus were different in the mice raised under GF v. NMF conditions, underlying the complex and dynamic nature of the host-commensal relationship. Differential expression of an array of genes described in this report evokes novel hypothesis of possible interactions between the probiotic bacteria and the host organism and warrants further studies to evaluate the functional significance of these transcriptional changes on the metabolic profile of the host. PMID:17433125

  14. Coordinate late expression of trefoil peptide genes (pS2/TFF1 and ITF/TFF3) in human breast, colon, and gastric tumor cells exposed to X-rays

    Science.gov (United States)

    Balcer-Kubiczek, Elizabeth K.; Harrison, George H.; Xu, Jing-Fan; Gutierrez, Peter L.

    2002-01-01

    The trefoil factors (TFFs) are pleiotropic factors involved in organization and homeostasis of the gastrointestinal tract, estrogen responsiveness, inflammatory disorders, and carcinogenesis. In an earlier study using cDNA array technologies to identify new genes expressed in irradiated cell survivors, we isolated a cDNA clone corresponding to the reported human TFF1 gene (E. K. Balcer-Kubiczek et al., Int. J. Radiat. Biol., 75: 529-541, 1999). To determine whether expression of other TFFs is altered by ionizing radiation, we quantified changes in expression of TFF3 as well as TFF1 in RNA samples obtained from irradiated and control human tumor breast, colon, and gastric tumor cells and examined expression kinetics up to 2 weeks after irradiation. X-ray-induced TFF1 and TFF3 expression profiles were compared with those induced by hydrogen peroxide (H2O2) or 17beta-estradiol (ES). The results revealed that TFF1 and TFF3 mRNA are coinduced by X-irradiation in a subset of the lines, but substantial heterogeneity in their responses was observed in cells derived from a single cell type. TFF1 and TFF3 transcriptional response to X-irradiation differed from that to H2O2 or ES in the timing of their induction as well as tissue-type dependence, i.e., their induction pattern after X-irradiation was late and sustained, whereas their induction by H2O2 or ES was early and transient. TFF1 mRNA, protein production in the cytoplasm, and secretion in the culture supernatant were coordinately regulated after X-irradiation. There was no requirement for TP53 in this induction. These results demonstrate the existence of a novel class of radiation-responsive genes that might be involved in bystander effects.

  15. Limitations of Radar Coordinates

    OpenAIRE

    Bini, Donato; Lusanna, Luca; Mashhoon, Bahram

    2004-01-01

    The construction of a radar coordinate system about the world line of an observer is discussed. Radar coordinates for a hyperbolic observer as well as a uniformly rotating observer are described in detail. The utility of the notion of radar distance and the admissibility of radar coordinates are investigated. Our results provide a critical assessment of the physical significance of radar coordinates.

  16. Coordinated Expression of fdxD and Molybdenum Nitrogenase Genes Promotes Nitrogen Fixation by Rhodobacter capsulatus in the Presence of Oxygen

    OpenAIRE

    Hoffmann, Marie-Christine; Müller, Alexandra; Fehringer, Maria; Pfänder, Yvonne; Narberhaus, Franz; Masepohl, Bernd

    2014-01-01

    Rhodobacter capsulatus is able to grow with N2 as the sole nitrogen source using either a molybdenum-dependent or a molybdenum-free iron-only nitrogenase whose expression is strictly inhibited by ammonium. Disruption of the fdxD gene, which is located directly upstream of the Mo-nitrogenase genes, nifHDK, abolished diazotrophic growth via Mo-nitrogenase at oxygen concentrations still tolerated by the wild type, thus demonstrating the importance of FdxD under semiaerobic conditions. In contras...

  17. Dual role of RsmA in the coordinated regulation of expression of virulence genes in Pectobacterium wasabiae strain SCC3193.

    Science.gov (United States)

    Andresen, Liis; Frolova, Jekaterina; Põllumaa, Lee; Mäe, Andres

    2015-11-01

    The CsrA/RsmA family of post-transcriptional regulators in bacteria is involved in regulating many cellular processes, including pathogenesis. Using a bioinformatics approach, we identified an RsmA binding motif, A(N)GGA, in the Shine-Dalgarno regions of 901 genes. Among these genes with the predicted RsmA binding motif, 358 were regulated by RsmA according to our previously published gene expression profiling analysis (WT vs rsmA negative mutant; Kõiv et al., 2013). A small subset of the predicted targets known to be important as virulence factors was selected for experimental validation. RNA footprint analyses demonstrated that RsmA binds specifically to the ANGGA motif in the 5'UTR sequences of celV1, pehA, pelB, pel2 and prtW. RsmA-dependent regulation of these five genes was examined in vivo using plasmid-borne translational and transcriptional fusions with a reporter gusA gene. They were all affected negatively by RsmA. However, we demonstrated that whereas the overall effect of RsmA on celV1 and prtW was determined on both the translational and transcriptional level, expression of pectinolytic enzyme genes (pehA, pel2 and pelB) was affected mainly on the level of transcription in tested conditions. In summary, these data indicate that RsmA controls virulence by integration of its regulatory activities at various levels. PMID:26306750

  18. Coordinated expression of two key enzyme genes pheA and aroF in phenylalanine biosynthesis pathway%苯丙氨酸生物合成关键酶基因pheA与aroF协同表达

    Institute of Scientific and Technical Information of China (English)

    芦佳; 黄坤央; 赵越; 徐琪寿; 郭军; 黄英武

    2012-01-01

    Objective:To develop a metabolically engineered E..coli strain for the overproduction of L-phenylalanine through optimization of protein expressions of two key genes pheA and aroF involved in L-phenylalanine biosynthesis pathway.Methods:We constructed two recombinant plasmids pZEI2-RBS-AF and pZE12-AF based on designing the DNA sequences of intergenic regulatory region between pheA and aroF.PheA and aroF protein expressions were observed by SDS-PAGE.Engineered E.coli strains were obtained by transforming the above two plasmids into an auxotrophic strain MGA and fermented for L- phenylalanine production.ResuLts: L- phenylalanine yield of the engineered strain MG△pZE12-AF was almost twice as high as that of the engineered strain MG△pZE12 -RBS-AR It was achieved by coordinated tandem expression of pheA and aroR Conclusion: Coordinated expression of L- phenylalanine biosynthesis enzymes can be obtained by adjusting intergenic regulatory sequences between tandem enzyme genes. It provides a new approach to improve the yield of engineered L-phenylalanine producing strain.%目的:优化L-苯丙氨酸生物合成通路上的关键酶基因pheA、aroF的蛋白表达,构建高产L-苯丙氨酸的工程菌株。方法:通过设计酶基因的间隔调控序列,分别构建重组质粒pZE12-RBS—AF和pZE12-AF,SDS—PAGE观察蛋白表达量,转入营养缺陷菌MGA中构建工程菌,并发酵培养。结果:工程菌MG△pZE12-AF苯丙氨酸的产量比工程菌MG△pZE12-RBs—AF高1倍,实现了L-苯丙氨酸生物合成关键酶基因pheA和aroF协同,匹配表达。结论:调整串联酶基因之间的间隔调控序列可实现苯丙氨酸合成酶基因的协同表达,提供了-种新的提高苯丙氨酸工程菌产量的方法。

  19. EXPRESS

    International Nuclear Information System (INIS)

    This paper presents EXPRESS, an expert system developed for the automation of reliability studies. The first part consists in the description of the method for static thermohydraulic systems. In this step, the authors define the knowledge representation based on the two inference engines - ALOUETTE and LCR developed by EDF. They explain all the process to construct a fault tree from a topological and functional description of the system. Numerous examples are exhibited in illustration of the method. This is followed by the lessons derived from the studies performed on some safety systems of the PALUEL nuclear plant. The development of the same approach for electric power systems is described, insisting on the difference resulting from the sequential nature of these systems. Finally, they show the main advantages identified during the studies

  20. The construction of Generalized Magnetic Coordinates

    International Nuclear Information System (INIS)

    Generalized Magnetic Coordinates (GMC) are curvilinear coordinates (ξ, η, ζ), in which the magnetic field is expressed in the form B=∇Ψ(ξ, η, ζ) x ∇ζ + Hζ(ξ, η)∇ξ x ∇η. The GMC construction algorithm is applied to the simple periodic model magnetic field. The coordinates are expanded in the Fourier series in three dimensions. It is obtained after about 10 - 35 times iterations. The coordinates are well constructed by the comparatively small number of Fourier modes. (author)

  1. Coordination and Cooperation

    OpenAIRE

    Janssen, Maarten

    2003-01-01

    textabstractThis comment makes four related points. First, explaining coordination is different from explaining cooperation. Second, solving the coordination problem is more important for the theory of games than solving the cooperation problem. Third, a version of the Principle of Coordination can be rationalized on individualistic grounds. Finally, psychological game theory should consider how players perceive their gaming situation. ---------------------------------------------------------...

  2. A Coordination Theory

    OpenAIRE

    J. Foss, Nicolai

    2009-01-01

    Important aspects of leadership behavior can be rendered intelligible through a focus on coordination games. The concept of common knowledge is shown to be particularly important to understanding leadership. Thus, leaders may establish common knowledge conditions and assist the coordination of strategies in this way, or make decisions in situations where coordination problems persist in spite of common knowledge.

  3. Quantifying linguistic coordination

    DEFF Research Database (Denmark)

    Fusaroli, Riccardo; Tylén, Kristian

    task (Bahrami et al 2010, Fusaroli et al. 2012) we extend to linguistic coordination dynamical measures of recurrence employed in the analysis of sensorimotor coordination (such as heart-rate (Konvalinka et al 2011), postural sway (Shockley 2005) and eye-movements (Dale, Richardson and Kirkham 2012...... linguistic coordination and their effects at a fine-degree....

  4. Establishment of magnetic coordinates for a given magnetic field

    International Nuclear Information System (INIS)

    A method is given for expressing the magnetic field strength in magnetic coordinates for a given field. This expression is central to the study of equilibrium, stability, and transport in asymmetric plasmas

  5. Motivic amplitudes and cluster coordinates

    International Nuclear Information System (INIS)

    In this paper we study motivic amplitudes — objects which contain all of the essential mathematical content of scattering amplitudes in planar SYM theory in a completely canonical way, free from the ambiguities inherent in any attempt to choose particular functional representatives. We find that the cluster structure on the kinematic configuration space Confn(ℙ3) underlies the structure of motivic amplitudes. Specifically, we compute explicitly the coproduct of the two-loop seven-particle MHV motivic amplitude A7,2M and find that like the previously known six-particle amplitude, it depends only on certain preferred coordinates known in the mathematics literature as cluster X-coordinates on Confn(ℙ3). We also find intriguing relations between motivic amplitudes and the geometry of generalized associahedrons, to which cluster coordinates have a natural combinatoric connection. For example, the obstruction to A7,2M being expressible in terms of classical polylogarithms is most naturally represented by certain quadrilateral faces of the appropriate associahedron. We also find and prove the first known functional equation for the trilogarithm in which all 40 arguments are cluster X-coordinates of a single algebra. In this respect it is similar to Abel’s 5-term dilogarithm identity

  6. Mapping brains without coordinates

    OpenAIRE

    Kötter, Rolf; Wanke, Egon

    2005-01-01

    Brain mapping has evolved considerably over the last century. While most emphasis has been placed on coordinate-based spatial atlases, coordinate-independent parcellation-based mapping is an important technique for accessing the multitude of structural and functional data that have been reported from invasive experiments, and provides for flexible and efficient representations of information. Here, we provide an introduction to motivations, concepts, techniques and implications of coordinate-...

  7. Adaptive Coordinate Descent

    OpenAIRE

    Loshchilov, Ilya; Schoenauer, Marc; Sebag, Michèle

    2011-01-01

    Independence from the coordinate system is one source of efficiency and robustness for the Covariance Matrix Adaptation Evolution Strategy (CMA-ES). The recently proposed Adaptive Encoding (AE) procedure generalizes CMA-ES adaptive mechanism, and can be used together with any optimization algorithm. Adaptive Encoding gradually builds a transformation of the coordinate system such that the new coordinates are as decorrelated as possible with respect to the objective function. But any optimizat...

  8. IVS Technology Coordinator Report

    Science.gov (United States)

    Whitney, Alan

    2013-01-01

    This report of the Technology Coordinator includes the following: 1) continued work to implement the new VLBI2010 system, 2) the 1st International VLBI Technology Workshop, 3) a VLBI Digital- Backend Intercomparison Workshop, 4) DiFX software correlator development for geodetic VLBI, 5) a review of progress towards global VLBI standards, and 6) a welcome to new IVS Technology Coordinator Bill Petrachenko.

  9. Coordinate measuring machines

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    This document is used in connection with three exercises of 2 hours duration as a part of the course GEOMETRICAL METROLOGY AND MACHINE TESTING. The exercises concern three aspects of coordinate measuring: 1) Measuring and verification of tolerances on coordinate measuring machines, 2) Traceabilit...

  10. On Reaction Coordinate Optimality.

    Science.gov (United States)

    Krivov, Sergei V

    2013-01-01

    The following question is addressed: how to establish that a constructed reaction coordinate is optimal, i.e., that it provides an accurate description of dynamics. It is shown that the reaction coordinate is optimal if its cut free energy profile, determined using length-weighted transitions, is constant, i.e., it is position and sampling interval independent. The observation leads to a number of interesting results. In particular, the equilibrium flux between two boundary states can be computed exactly as diffusion on a free energy profile associated with the coordinate. The mean square displacement, for the trajectory projected onto the coordinate, grows linear with time. That for the same trajectory projected onto a suboptimal coordinate grows slower than linear with time. The results are illustrated on a number of model systems, Sierpinski gasket, FIP35 protein, and beta3s peptide. PMID:26589017

  11. Coordination failure caused by sunspots

    DEFF Research Database (Denmark)

    Beugnot, Julie; Gürgüç, Zeynep; Øvlisen, Frederik Roose; Roos, Michael M. W.

    2012-01-01

    In a coordination game with Pareto-ranked equilibria, we study whether a sunspot can lead to either coordination on an inferior equilibrium (mis-coordination) or to out-of equilibrium behavior (dis-coordination). While much of the literature searches for mechanisms to attain coordination on the e......-dominant equilibrium, but in the sunspot treatment, dis-coordination is frequent. Sunspots lead to significant inefficiency, and we conclude that sunspots can indeed cause coordination failure....

  12. Supercritical Airfoil Coordinates

    Data.gov (United States)

    National Aeronautics and Space Administration — Rectangular Supercritical Wing (Ricketts) - design and measured locations are provided in an Excel file RSW_airfoil_coordinates_ricketts.xls . One sheet is with Non...

  13. Movement and Coordination

    Science.gov (United States)

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP Find a Pediatrician ... Movement and Coordination Page Content Article Body At this age, your child will seem to be continually on the go— ...

  14. Coordination and Policy Traps

    OpenAIRE

    Angeletos, George-Marios; Hellwig, Christian; Pavan, Alessandro

    2003-01-01

    This paper examines the ability of a policy maker to control equilibrium outcomes in an environment where market participants play a coordination game with information heterogeneity. We consider defense policies against speculative currency attacks in a model where speculators observe the fundamentals with idiosyncratic noise. The policy maker is willing to take a costly policy action only for moderate fundamentals. Market participants can use this information to coordinate on di.erent respon...

  15. Attribute coordination in organizations

    OpenAIRE

    Yingyi Qian; Gerard Roland; Chenggang Xu

    2001-01-01

    We study coordination in organizations with a variety of organizational forms. Coordination in organization is modeled as the adjustment of attributes and capacities of tasks when facing external shocks. An M-form (U-form) organization groups complementary (substitutable) tasks together in one unit. In the presence of only attribute shocks, particularly when gains from specialization are small, communication is poor, or shocks are more likely, the expected payoff of the decentralized M-form i...

  16. Continuous parallel coordinates.

    Science.gov (United States)

    Heinrich, Julian; Weiskopf, Daniel

    2009-01-01

    Typical scientific data is represented on a grid with appropriate interpolation or approximation schemes,defined on a continuous domain. The visualization of such data in parallel coordinates may reveal patterns latently contained in the data and thus can improve the understanding of multidimensional relations. In this paper, we adopt the concept of continuous scatterplots for the visualization of spatially continuous input data to derive a density model for parallel coordinates. Based on the point-line duality between scatterplots and parallel coordinates, we propose a mathematical model that maps density from a continuous scatterplot to parallel coordinates and present different algorithms for both numerical and analytical computation of the resulting density field. In addition, we show how the 2-D model can be used to successively construct continuous parallel coordinates with an arbitrary number of dimensions. Since continuous parallel coordinates interpolate data values within grid cells, a scalable and dense visualization is achieved, which will be demonstrated for typical multi-variate scientific data. PMID:19834230

  17. Magnetic Coordinate Systems

    Science.gov (United States)

    Laundal, K. M.; Richmond, A. D.

    2016-07-01

    Geospace phenomena such as the aurora, plasma motion, ionospheric currents and associated magnetic field disturbances are highly organized by Earth's main magnetic field. This is due to the fact that the charged particles that comprise space plasma can move almost freely along magnetic field lines, but not across them. For this reason it is sensible to present such phenomena relative to Earth's magnetic field. A large variety of magnetic coordinate systems exist, designed for different purposes and regions, ranging from the magnetopause to the ionosphere. In this paper we review the most common magnetic coordinate systems and describe how they are defined, where they are used, and how to convert between them. The definitions are presented based on the spherical harmonic expansion coefficients of the International Geomagnetic Reference Field (IGRF) and, in some of the coordinate systems, the position of the Sun which we show how to calculate from the time and date. The most detailed coordinate systems take the full IGRF into account and define magnetic latitude and longitude such that they are constant along field lines. These coordinate systems, which are useful at ionospheric altitudes, are non-orthogonal. We show how to handle vectors and vector calculus in such coordinates, and discuss how systematic errors may appear if this is not done correctly.

  18. Generator Coordinate Truncations

    CERN Document Server

    Hagino, K; Reinhard, P G

    2003-01-01

    We investigate the accuracy of several schemes to calculate ground-state correlation energies using the generator coordinate technique. Our test-bed for the study is the $sd$ interacting boson model, equivalent to a 6-level Lipkin-type model. We find that the simplified projection of a triaxial generator coordinate state using the $S_3$ subgroup of the rotation group is not very accurate in the parameter space of the Hamiltonian of interest. On the other hand, a full rotational projection of an axial generator coordinate state gives remarkable accuracy. We also discuss the validity of the simplified treatment using the extended Gaussian overlap approximation (top-GOA), and show that it works reasonably well when the number of boson is four or larger.

  19. Coordination and citizen participation.

    Science.gov (United States)

    Tucker, D J

    1980-03-01

    This study investigates the validity of the assumption that coordination and citizen participation are related inversely and, thus, are incompatible as features in the same social service reform strategy. Seventeen social service organizations situated in the same urban area were studied. Data were obtained by structured interview. The concepts of coordination and citizen participation were operationalized by means of scales. The findings support the validity of the assumption noted above. Although interpretations of the findings can be provided, they are post-factum. This implies a need for explanatory research which might be guided by theories of community power structure and of organizational behavior. PMID:10246483

  20. Introduction to Coordination Chemistry

    CERN Document Server

    Lawrance, Geoffrey Alan

    2010-01-01

    Introduction to Coordination Chemistry examines and explains how metals and molecules that bind as ligands interact, and the consequences of this assembly process. This book describes the chemical and physical properties and behavior of the complex assemblies that form, and applications that may arise as a result of these properties. Coordination complexes are an important but often hidden part of our world?even part of us?and what they do is probed in this book. This book distills the essence of this topic for undergraduate students and for research scientists.

  1. Synaptic Plasticity and NO-cGMP-PKG Signaling Coordinately Regulate ERK-Driven Gene Expression in the Lateral Amygdala and in the Auditory Thalamus Following Pavlovian Fear Conditioning

    Science.gov (United States)

    Ota, Kristie T.; Monsey, Melissa S.; Wu, Melissa S.; Young, Grace J.; Schafe, Glenn E.

    2010-01-01

    We have recently hypothesized that NO-cGMP-PKG signaling in the lateral nucleus of the amygdala (LA) during auditory fear conditioning coordinately regulates ERK-driven transcriptional changes in both auditory thalamic (MGm/PIN) and LA neurons that serve to promote pre- and postsynaptic alterations at thalamo-LA synapses, respectively. In the…

  2. Recursive Advice for Coordination

    DEFF Research Database (Denmark)

    Terepeta, Michal Tomasz; Nielson, Hanne Riis; Nielson, Flemming

    Aspect-oriented programming is a programming paradigm that is often praised for the ability to create modular software and separate cross-cutting concerns. Recently aspects have been also considered in the context of coordination languages, offering similar advantages. However, introducing aspect...... systems. Even though primarily used for analysis of recursive programs, we are able to adapt them to fit this new context....

  3. Coordination of mobile labor

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub

    2008-01-01

    Roč. 139, č. 1 (2008), s. 25-46. ISSN 0022-0531 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:AV0Z70850503 Keywords : coordination * general equilibrium * global game s Subject RIV: AH - Economics Impact factor: 1.224, year: 2008

  4. Facets of coordination chemistry

    CERN Document Server

    Agarwala, BV

    1993-01-01

    A concise account of coordination chemistry since its inception is given here together with some of the newer significant facets. This book covers a broad spectrum of various topics on Environment, Cyclic Voltammetry, Chromatography, Metal Complexes of biological interest, Alkoxides, NMR spectroscopy and others. These are useful to the scientific community engaged in the field of Inorganic Chemistry and Analytical Chemistry.

  5. Coordinating Work with Groupware

    DEFF Research Database (Denmark)

    Pors, Jens Kaaber; Simonsen, Jesper

    One important goal of employing groupware is to make possible complex collaboration between geographically distributed groups. This requires a dual transformation of both technology and work practice. The challenge is to re­duce the complexity of the coordination work by successfully inte­grating...

  6. Conformal Fermi Coordinates

    CERN Document Server

    Dai, Liang; Schmidt, Fabian

    2015-01-01

    Fermi Normal Coordinates (FNC) are a useful frame for isolating the locally observable, physical effects of a long-wavelength spacetime perturbation. Their cosmological application, however, is hampered by the fact that they are only valid on scales much smaller than the horizon. We introduce a generalization that we call Conformal Fermi Coordinates (CFC). CFC preserve all the advantages of FNC, but in addition are valid outside the horizon. They allow us to calculate the coupling of long- and short-wavelength modes on all scales larger than the sound horizon of the cosmological fluid, starting from the epoch of inflation until today, by removing the complications of the second order Einstein equations to a large extent, and eliminating all gauge ambiguities. As an application, we present a calculation of the effect of long-wavelength tensor modes on small scale density fluctuations. We recover previous results, but clarify the physical content of the individual contributions in terms of locally measurable ef...

  7. Principles of Coordination Polymerisation

    Science.gov (United States)

    Kuran, Witold

    2001-11-01

    The first all-inclusive text covering coordination polymerisation, including important classes of non-hydrocarbon monomers. Charting the achievements and progress in the field, in terms of both basic and industrial research, this book offers a unified and complete overview of coordination polymerisation. Provides detailed description of the historical development of the subject Presents a unified view of catalysis, mechanisms, structures and utility Encourages learning through a step-by-step progression from basic to in-depth text Features end-of-chapter exercises to reinforce understanding Offers a full bibliography and comprehensive literature review Requisite reading for research students studying introductory and advanced courses in; polymer science, catalysis and polymerisation catalysis, and valuable reference for researchers and technicians in industry.

  8. SIMULATING THE SUPPLY DISRUPTION FOR THE COORDINATED SUPPLY CHAIN

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    There are many disruptive accidents in the supply chain operations system and achieving the coordination of supply chain is main objective for supply chain research. While disruptive accidents have increasingly influenced the coordinated operation of the supply chain, existing research literature on the supply chain coordination is setting in a stationary environment. The answer for how the disruptive accidents affect the coordinated supply chain is given in this paper. Based on the benchmark supply chain which is coordinated by the negative incentive mechanism, we study the impacts of supply disruption on the supply chain system by using simulation approach in which two different distribution function of random variable are used to express the supply disruption. Comparison between these two simulation results and possible coordination mechanism under the supply disruption are proposed. From the perspective of supply chain risk management, we provide the inspiration for the manager.

  9. Communicating Processes with Data for Supervisory Coordination

    Directory of Open Access Journals (Sweden)

    Jasen Markovski

    2012-08-01

    Full Text Available We employ supervisory controllers to safely coordinate high-level discrete(-event behavior of distributed components of complex systems. Supervisory controllers observe discrete-event system behavior, make a decision on allowed activities, and communicate the control signals to the involved parties. Models of the supervisory controllers can be automatically synthesized based on formal models of the system components and a formalization of the safe coordination (control requirements. Based on the obtained models, code generation can be used to implement the supervisory controllers in software, on a PLC, or an embedded (microprocessor. In this article, we develop a process theory with data that supports a model-based systems engineering framework for supervisory coordination. We employ communication to distinguish between the different flows of information, i.e., observation and supervision, whereas we employ data to specify the coordination requirements more compactly, and to increase the expressivity of the framework. To illustrate the framework, we remodel an industrial case study involving coordination of maintenance procedures of a printing process of a high-tech Oce printer.

  10. Communication and interference coordination

    OpenAIRE

    Blasco-Serrano, Ricardo; Thobaben, Ragnar; Skoglund, Mikael

    2014-01-01

    We study the problem of controlling the interference created to an external observer by a communication processes. We model the interference in terms of its type (empirical distribution), and we analyze the consequences of placing constraints on the admissible type. Considering a single interfering link, we characterize the communication-interference capacity region. Then, we look at a scenario where the interference is jointly created by two users allowed to coordinate their actions prior to...

  11. Advertising and Coordination

    OpenAIRE

    1990-01-01

    We show that when relevant market information such as price is difficult to communicate, advertising plays a key role in bringing about optimal coordination of purchase behavior: an efficient firm uses advertising expenditures in place of price to inform sophisticated consumers that it offers a better deal. This provides a theoretical explanation for Benham's (1972) empirical association of the ability to advertise with lower prices and larger scale. We find that advertising improves welfare ...

  12. Improving Project Manufacturing Coordination

    Directory of Open Access Journals (Sweden)

    Korpivaara Ville

    2014-09-01

    Full Text Available The objective of this research is to develop firms’ project manufacturing coordination. The development will be made by centralizing the manufacturing information flows in one system. To be able to centralize information, a deep user need assessment is required. After user needs have been identified, the existing system will be developed to match these needs. The theoretical background is achieved through exploring the literature of project manufacturing, development project success factors and different frameworks and tools for development project execution. The focus of this research is rather in customer need assessment than in system’s technical expertise. To ensure the deep understanding of customer needs this study is executed by action research method. As a result of this research the information system for project manufacturing coordination was developed to respond revealed needs of the stakeholders. The new system improves the quality of the manufacturing information, eliminates waste in manufacturing coordination processes and offers a better visibility to the project manufacturing. Hence it provides a solid base for the further development of project manufacturing.

  13. Disorder of written expression

    Science.gov (United States)

    ... coordination disorder (includes poor handwriting) Expressive language disorder Mathematics disorder Reading disorder ... JW III, Schor NF, Behrman RE, eds. Nelson Textbook of Pediatrics . 19th ed. Philadelphia, PA: Elsevier Saunders; ...

  14. Communication, leadership and coordination failure

    OpenAIRE

    Dong, Lu; Montero, Maria; Possajennikov, Alex

    2015-01-01

    Using experimental methods, this paper investigates the limits of communication and leadership in aiding group coordination in a minimum effort game. Choosing the highest effort is the payoff dominant Nash equilibrium in this game, and communication and leadership are expected to help in coordinating on such an equilibrium. We consider an environment in which the benefits of coordination are low compared to the cost of mis-coordination. In this environment, players converge to the most ineffi...

  15. Communication, Leadership and Coordination Failure

    OpenAIRE

    Lu Dong; Maria Montero; Alex Possajennikov

    2015-01-01

    Using experimental methods, this paper investigates the limits of communication and leadership in aiding group coordination in a minimum effort game. Choosing the highest effort is the payoff dominant Nash equilibrium in this game, and communication and leadership are expected to help in coordinating on such an equilibrium. We consider an environment in which the benefits of coordination are low compared to the cost of mis-coordination. In this environment, players converge to the most ineffi...

  16. Modeling Students' Units Coordinating Activity

    OpenAIRE

    Boyce, Steven James

    2014-01-01

    Primarily via constructivist teaching experiment methodology, units coordination (Steffe, 1992) has emerged as a useful construct for modeling students' psychological constructions pertaining to several mathematical domains, including counting sequences, whole number multiplicative conceptions, and fractions schemes. I describe how consideration of units coordination as a Piagetian (1970b) structure is useful for modeling units coordination across contexts. In this study, I extend teaching ...

  17. Coordination Processes in International Organisations

    DEFF Research Database (Denmark)

    Nedergaard, Peter

    2008-01-01

    The EU is not a member of the International Labour Organisation (ILO), but relatively elaborate EU coordination takes place anyway. This paper addresses two research questions: 1) How is it possible to evaluate the coordination of the EU in its specific observable configuration in the ILO?, and 2......) To what outcome does this coordination lead and why? Based on an analysis of EU coordination before and during the International Labour Conference in 2005, and on a comparison with coordination processes of the IMEC group, it is found that the Commission and the Presidency act as twin-agents vis...

  18. An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma

    Directory of Open Access Journals (Sweden)

    Agnelli Luca

    2008-08-01

    Full Text Available Abstract Background The role of microRNAs (miRNAs in multiple myeloma (MM has yet to be fully elucidated. To identify miRNAs that are potentially deregulated in MM, we investigated those mapping within transcription units, based on evidence that intronic miRNAs are frequently coexpressed with their host genes. To this end, we monitored host transcript expression values in a panel of 20 human MM cell lines (HMCLs and focused on transcripts whose expression varied significantly across the dataset. Methods miRNA expression was quantified by Quantitative Real-Time PCR. Gene expression and genome profiling data were generated on Affymetrix oligonucleotide microarrays. Significant Analysis of Microarrays algorithm was used to investigate differentially expressed transcripts. Conventional statistics were used to test correlations for significance. Public libraries were queried to predict putative miRNA targets. Results We identified transcripts specific to six miRNA host genes (CCPG1, GULP1, EVL, TACSTD1, MEST, and TNIK whose average changes in expression varied at least 2-fold from the mean of the examined dataset. We evaluated the expression levels of the corresponding intronic miRNAs and identified a significant correlation between the expression levels of MEST, EVL, and GULP1 and those of the corresponding miRNAs miR-335, miR-342-3p, and miR-561, respectively. Genome-wide profiling of the 20 HMCLs indicated that the increased expression of the three host genes and their corresponding intronic miRNAs was not correlated with local copy number variations. Notably, miRNAs and their host genes were overexpressed in a fraction of primary tumors with respect to normal plasma cells; however, this finding was not correlated with known molecular myeloma groups. The predicted putative miRNA targets and the transcriptional profiles associated with the primary tumors suggest that MEST/miR-335 and EVL/miR-342-3p may play a role in plasma cell homing and

  19. Network Coordinator Report

    Science.gov (United States)

    Himwich, Ed; Strand, Richard

    2013-01-01

    This report includes an assessment of the network performance in terms of lost observing time for the 2012 calendar year. Overall, the observing time loss was about 12.3%, which is in-line with previous years. A table of relative incidence of problems with various subsystems is presented. The most significant identified causes of loss were electronics rack problems (accounting for about 21.8% of losses), antenna reliability (18.1%), RFI (11.8%), and receiver problems (11.7%). About 14.2% of the losses occurred for unknown reasons. New antennas are under development in the USA, Germany, and Spain. There are plans for new telescopes in Norway and Sweden. Other activities of the Network Coordinator are summarized.

  20. Coordination using Implicit Communication

    CERN Document Server

    Cuff, Paul

    2011-01-01

    We explore a basic noise-free signaling scenario where coordination and communication are naturally merged. A random signal X_1,...,X_n is processed to produce a control signal or action sequence A_1,...,A_n, which is observed and further processed (without access to X_1,...,X_n) to produce a third sequence B_1,...,B_n. The object of interest is the set of empirical joint distributions p(x,a,b) that can be achieved in this setting. We show that H(A) >= I(X;A,B) is the necessary and sufficient condition for achieving p(x,a,b) when no causality constraints are enforced on the encoders. We also give results for various causality constraints. This setting sheds light on the embedding of digital information in analog signals, a concept that is exploited in digital watermarking, steganography, cooperative communication, and strategic play in team games such as bridge.

  1. Coordinating Group report

    International Nuclear Information System (INIS)

    In December 1992, western governors and four federal agencies established a Federal Advisory Committee to Develop On-site Innovative Technologies for Environmental Restoration and Waste Management (the DOIT Committee). The purpose of the Committee is to advise the federal government on ways to improve waste cleanup technology development and the cleanup of federal sites in the West. The Committee directed in January 1993 that information be collected from a wide range of potential stakeholders and that innovative technology candidate projects be identified, organized, set in motion, and evaluated to test new partnerships, regulatory approaches, and technologies which will lead to improve site cleanup. Five working groups were organized, one to develop broad project selection and evaluation criteria and four to focus on specific contaminant problems. A Coordinating Group comprised of working group spokesmen and federal and state representatives, was set up to plan and organize the routine functioning of these working groups. The working groups were charged with defining particular contaminant problems; identifying shortcomings in technology development, stakeholder involvement, regulatory review, and commercialization which impede the resolution of these problems; and identifying candidate sites or technologies which could serve as regional innovative demonstration projects to test new approaches to overcome the shortcomings. This report from the Coordinating Group to the DOIT Committee highlights the key findings and opportunities uncovered by these fact-finding working groups. It provides a basis from which recommendations from the DOIT Committee to the federal government can be made. It also includes observations from two public roundtables, one on commercialization and another on regulatory and institutional barriers impeding technology development and cleanup

  2. Coordinating distributed work: Exploring situated coordination with gaming-simulation

    OpenAIRE

    van Laere, J.

    2003-01-01

    Organizational work has become more and more distributed nowadays. Information and communication technologies (ICT) provide opportunities to improve coordination of distributed work, but in practice many organizations struggle with integrating new organizational structures, new work practices and ICT. In this dissertation we present a design approach for improving the coordination of distributed work. First we develop an integrated view on coordination, based on observations of current coordi...

  3. Coordinate-free logic

    NARCIS (Netherlands)

    Leo, Joop

    2015-01-01

    A new logic is presented without predicates-except equality. Yet its expressive power is the same as that of predicate logic, and relations can faithfully be represented in it. In this logic we also develop an alternative for set theory. There is a need for such a new approach, since we do not live

  4. N=4 superfield phase space coordinates and Hamiltonian quantization

    International Nuclear Information System (INIS)

    The N=4 superfield phase space coordinates are given in the harmonic superspace. The expressions of the N=4 classical equations of motion are determined in terms of the spinorial and harmonic supercharges. Furthermore, the N=4 supersymmetric actions are obtained by means of the fermionic and harmonic functionals. On the other hand, the Hamiltonian quantization is studied by performing the N=4 supersymmetric action in harmonic subspace in terms of analytic N=4 superfield phase space coordinates. (author)

  5. 78 FR 73819 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-12-09

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of...-18, 2013 meeting of the Forest Resource Coordinating Committee due to the Government partial shutdown... INFORMATION CONTACT: Maya Solomon, Forest Resource Coordinating Committee Program Coordinator; by phone...

  6. Coordinate transformations in quaternion spaces

    OpenAIRE

    Weng, Zihua

    2008-01-01

    The quaternion spaces can be used to describe the property of electromagnetic field and gravitational field. In the quaternion space, some coordinate transformations can be deduced from the feature of quaternions, including Lorentz transformation and Galilean transformation etc., when the coordinate system is transformed into others. And some coordinate transformations with variable speed of light can be obtained in the electromagnetic field and gravitational field.

  7. Enterprise Coordination on the Internet

    OpenAIRE

    Charles Petrie

    2011-01-01

    Enterprises are now connected internally and externally to other Enterprises via the Internet in ways that are increasingly difficult to manage, especially as these interconnections become more dynamic. Current methods of coordinating the effects of change as they propagate through these networks of connections are not likely to scale. What is needed is a new paradigm for how the Internet supports such coordination. Indeed, the Internet should and could provide fundamental coordination functi...

  8. Child Labor and Coordination Failures

    OpenAIRE

    Sylvain Dessy; Stephane Pallage

    2000-01-01

    In this paper, we show how coordination failures may explain the prevalence of child labor in developing countries. We do so within a simple game-theoretic setup. Child labor arises in our environment because of the lack of a coordination mechanism between parental decisions to invest in the human capital of their children and firm's decisions to invest in skill-intensive technology. Governmental policies that help coordinate expectations lead to the disappearance of child labor.

  9. Coordinated microRNA and messenger RNA expression profiles for understanding sexual dimorphism of gonads and the potential roles of microRNA in the steroidogenesis pathway in Nile tilapia (Oreochromis niloticus).

    Science.gov (United States)

    Wang, Weiwei; Liu, Wenzhong; Liu, Qing; Li, Baojun; An, Lixia; Hao, Ruirong; Zhao, Jinliang; Liu, Shaozhen; Song, Jing

    2016-03-15

    Sexual dimorphism is a widespread phenomenon in animals. However, the potential role of microRNAs (miRNAs) in regulating this dimorphism is not fully understood. In our study, we used an integrated approach to identify functional targets of miRNA by combining the paired expression profiles of miRNAs and messenger RNAs (mRNAs) in ovaries and testes of young Nile tilapia, Oreochromis niloticus. The results revealed that 67 upregulated and nine downregulated miRNAs and 2299 upregulated and 3260 downregulated genes were identified in the ovary compared with those in the testis (P < 0.01). The target genes of differentially expressed miRNAs were predicted and overlapped with the differentially expressed mRNAs. Furthermore, Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted in these coincident genes. By correlating miRNA-mRNA and predicting computational target, two types of negatively regulatory miRNA-mRNA correlations (upregulated or downregulated miRNA and downregulated or upregulated mRNA) were obtained. Seven functional miRNA-target gene pairs, miR-17-5p/DMRT1, miR-20a/DMRT1, miR-138/CYP17A2, miR-338/CYP17A2, miR-200a/CYP17A2, miR-456/AMH, and miR-138/AMH, were predicted at the sequence level and further detected by real-time polymerase chain reaction on the basis of the significantly negative relationships. Our results suggest that the integrated analysis of miRNA and mRNA expression profiling can provide novel insights into the molecular mechanism of sexual dimorphism. PMID:26719037

  10. On Coordinating Collaborative Objects

    Directory of Open Access Journals (Sweden)

    Abdessamad Imine

    2010-07-01

    Full Text Available A collaborative object represents a data type (such as a text document designed to be shared by a group of dispersed users. The Operational Transformation (OT is a coordination approach used for supporting optimistic replication for these objects. It allows the users to concurrently update the shared data and exchange their updates in any order since the convergence of all replicas, i.e. the fact that all users view the same data, is ensured in all cases. However, designing algorithms for achieving convergence with the OT approach is a critical and challenging issue. In this paper, we propose a formal compositional method for specifying complex collaborative objects. The most important feature of our method is that designing an OT algorithm for the composed collaborative object can be done by reusing the OT algorithms of component collaborative objects. By using our method, we can start from correct small collaborative objects which are relatively easy to handle and incrementally combine them to build more complex collaborative objects.

  11. Research of Coordinate Development of Professional Market, E-commerce and Express Industry:Based on the Construction of MID-Zhejiang Urban Agglomerations%专业市场、电子商务与快递业联动发展研究——基于浙中城市群建设的思考

    Institute of Scientific and Technical Information of China (English)

    陈庆

    2013-01-01

    The growth of e-commerce is closely related to the development of express industry.However,in Mid-Zhejiang urban agglomerations whose core is professional market construction,the mutual improvement relationship with coordinated development between the professional market and the express industry has not been established.The joint development of professional market,e-commerce and express industry has become an important driving force for regional economic development.%电子商务的成长与快递业的发展息息相关,而在以专业市场建设为核心的浙中城市群中,专业市场却一直无法与快递业建立协同发展的相互促进关系.专业市场、电子商务与快递业的联动发展研究已经成为区域经济发展的重要推动力.

  12. 75 FR 55947 - Coordinated Communications

    Science.gov (United States)

    2010-09-15

    ... Proposed Rulemaking on Coordinated Communications, 75 FR 6590 (Feb. 10, 2010). The SNPRM invited comments..., 68 FR at 427. The first content standard was satisfied if the communication was an electioneering... Proposed Rulemaking on Coordinated ] Communications, 70 FR 73946 (Dec. 14, 2005) (``2005 NPRM'')....

  13. Coordinated Transportation: Problems and Promise?

    Science.gov (United States)

    Fickes, Michael

    1998-01-01

    Examines the legal, administrative, and logistical barriers that have prevented the wide acceptance of coordinating community and school transportation services and why these barriers may be breaking down. Two examples of successful implementation of coordinated transportation are examined: employing a single system to serve all transportation…

  14. Coordinate-Free Rotation Operator.

    Science.gov (United States)

    Leubner, C.

    1979-01-01

    Suggests the use of a coordinate-free rotation operator for the teaching of rotations in Euclidean three space because of its twofold didactic advantage. Illustrates the potentialities of the coordinate-free rotation operator approach by a number of examples. (Author/GA)

  15. Coordination of Conditional Poisson Samples

    Directory of Open Access Journals (Sweden)

    Grafström Anton

    2015-12-01

    Full Text Available Sample coordination seeks to maximize or to minimize the overlap of two or more samples. The former is known as positive coordination, and the latter as negative coordination. Positive coordination is mainly used for estimation purposes and to reduce data collection costs. Negative coordination is mainly performed to diminish the response burden of the sampled units. Poisson sampling design with permanent random numbers provides an optimum coordination degree of two or more samples. The size of a Poisson sample is, however, random. Conditional Poisson (CP sampling is a modification of the classical Poisson sampling that produces a fixed-size πps sample. We introduce two methods to coordinate Conditional Poisson samples over time or simultaneously. The first one uses permanent random numbers and the list-sequential implementation of CP sampling. The second method uses a CP sample in the first selection and provides an approximate one in the second selection because the prescribed inclusion probabilities are not respected exactly. The methods are evaluated using the size of the expected sample overlap, and are compared with their competitors using Monte Carlo simulation. The new methods provide a good coordination degree of two samples, close to the performance of Poisson sampling with permanent random numbers.

  16. Lorentz gauge quantization in synchronous coordinates

    CERN Document Server

    Garner, Christopher

    2016-01-01

    It has been shown that the Gupta-Bleuler method of quantization can be used to impose the Lorentz gauge condition in static space-times but not in cosmological space-times. This implies that the Gupta-Bleuler approach fails in general in non-static space-times. More recently, however, the Dirac method of quantizing constrained dynamical systems has been successfully employed to impose the Lorentz gauge in conformally flat space-times. In this paper we generalize this result by using Dirac's method to impose the Lorentz gauge in a general space-time region where the metric is expressed in synchronous coordinates.

  17. Coordination and Multi-Tasking Using EMT

    OpenAIRE

    Rabinovich, Zinovi; Pochter, Nir; Rosenschein, Jeffrey S.

    2008-01-01

    We introduce a multi-model variant of the EMT-based control algorithm. The new algorithm, MM-EMT, is capable of balancing several control tasks expressed using separate dynamic models with a common action space. Such multiple models are common in both single-agent environments, when the agent has multiple tasks to achieve, and in team activities, when agent actions affect both the local agent’s task as well as the overall team’s coordination. To demonstrate the behaviour that MM-EMT engenders...

  18. Coordinating Networks of Robotic Observatories

    Science.gov (United States)

    Mason, C. L.

    1993-12-01

    This abstract describes our project on scheduling for networks of remote robotic telescopes. The project is being developed as part of our larger goal to build automated tools to address the complete life-cycle of an observation request, from electronic transmission of the observation request to the return of raw and reduced data, using the Automatic Telescope Instruction Set, or ATIS. With distributed artificial intelligence (DAI) software techniques, we have designed a network scheduling system as a collection of distributed, cooperating scheduling agents. Each agent is responsible for the scheduling of observation requests for one robotic telescope. This perspective allows the network scheduling system to preserve the individualized priorities and policies that may exist for any one telescope while promoting the collaborative behavior required for acquiring and providing telescope time in a network. We are interested in heterogeneous networks that are made by connecting pre-existing fully automated remote telescopes. Providers of telescopes are anyone with a fully automated telescope and telecommunication capabilities. In essence, the network system is created by interconnecting multiple stand-alone systems. The scheduling software for each stand-alone system (or agent) is based on two primary components: an advanced scheduling system, CERES, that employs look-ahead contingent scheduling methods, and a collaborator, that communicates with other agents in the network, both written in C and Lisp. Cooperation among agents is based on the premise that astronomers at one telescope are often willing to trade for time on another telescope. In general, agents are autonomous but may react cooperatively to observational requests communicated by other scheduling agents. Our work involves engineering the protocols for cooperation, and the development of a programming language and agent architecture to express such protocols. The system is being constructed with the help of

  19. Keep Meaning in Conversational Coordination

    Directory of Open Access Journals (Sweden)

    Elena Clare Cuffari

    2014-12-01

    Full Text Available Coordination is a widely employed term across recent quantitative and qualitative approaches to intersubjectivity, particularly approaches that give embodiment and enaction central explanatory roles. With a focus on linguistic and bodily coordination in conversational contexts, I review the operational meaning of coordination in recent empirical research and related theorizing of embodied intersubjectivity. This discussion articulates what must be involved in treating linguistic meaning as dynamic processes of coordination. The coordination approach presents languaging as a set of dynamic self-organizing processes and actions on multiple timescales and across multiple modalities that come about and work in certain domains (those jointly constructed in social, interactive, high-order sense-making. These processes go beyond meaning at the level that is available to first-person experience. I take one crucial consequence of this to be the ubiquitously moral nature of languaging with others. Languaging coordinates experience, among other levels of behavior and event. Ethical effort is called for by the automatic autonomy-influencing forces of languaging as coordination.

  20. Coordinating distributed work: Exploring situated coordination with gaming-simulation

    NARCIS (Netherlands)

    van Laere, J.

    2003-01-01

    Organizational work has become more and more distributed nowadays. Information and communication technologies (ICT) provide opportunities to improve coordination of distributed work, but in practice many organizations struggle with integrating new organizational structures, new work practices and IC

  1. The coordinate transforming in geography information system

    International Nuclear Information System (INIS)

    The coordinate transforming of geography information system includes two kinds of transforming, map projection and coordinate-transforming. This paper proposed a arithmetic of coordinate-transforming, it implement the transforming between the longitude-latitude coordinate and the screen coordinate and apply it in the GIS. The preferable effect was made. (authors)

  2. Evaluating the Relational Coordination instrument

    DEFF Research Database (Denmark)

    Edwards, Kasper; Lundstrøm, Sanne Lykke

    2014-01-01

    and surgical performance. This has prompted the attention of both practitioners and politicians some of who perceive relational coordination as a means to attain better performance. The relational coordination instrument has been validated as a measure of teamwork from the following perspectives......: internal consistency, interrater agreement and reliability, structural validity, content validity. However as relational coordination is being used as a diagnostics tool it is important to examine further if the instrument can measure changes. Indeed we need to know how precise and sensitive the instrument...... the change using the relational coordination instrument. Managers were interviewed before the projects and a chronicle workshop (structured group interview) were performed after the project. This design allows us to compare the qualitative descriptions of change in the wards, with the measured change...

  3. Coordination Games on Dynamical Networks

    Directory of Open Access Journals (Sweden)

    Enea Pestelacci

    2010-07-01

    Full Text Available We propose a model in which agents of a population interacting according to a network of contacts play games of coordination with each other and can also dynamically break and redirect links to neighbors if they are unsatisfied. As a result, there is co-evolution of strategies in the population and of the graph that represents the network of contacts. We apply the model to the class of pure and general coordination games. For pure coordination games, the networks co-evolve towards the polarization of different strategies. In the case of general coordination games our results show that the possibility of refusing neighbors and choosing different partners increases the success rate of the Pareto-dominant equilibrium.

  4. Who matters in coordination problems?

    Czech Academy of Sciences Publication Activity Database

    Sákovics, J.; Steiner, Jakub

    2012-01-01

    Roč. 102, č. 7 (2012), s. 3439-3461. ISSN 0002-8282 Institutional support: RVO:67985998 Keywords : coordination problems * heterogeneous agents Subject RIV: AH - Economics Impact factor: 2.792, year: 2012

  5. Markov Tracking for Agent Coordination

    Science.gov (United States)

    Washington, Richard; Lau, Sonie (Technical Monitor)

    1998-01-01

    Partially observable Markov decision processes (POMDPs) axe an attractive representation for representing agent behavior, since they capture uncertainty in both the agent's state and its actions. However, finding an optimal policy for POMDPs in general is computationally difficult. In this paper we present Markov Tracking, a restricted problem of coordinating actions with an agent or process represented as a POMDP Because the actions coordinate with the agent rather than influence its behavior, the optimal solution to this problem can be computed locally and quickly. We also demonstrate the use of the technique on sequential POMDPs, which can be used to model a behavior that follows a linear, acyclic trajectory through a series of states. By imposing a "windowing" restriction that restricts the number of possible alternatives considered at any moment to a fixed size, a coordinating action can be calculated in constant time, making this amenable to coordination with complex agents.

  6. Kaluza's theory in generalized coordinates

    CERN Document Server

    García-Perciante, A L; García-Colin, L S; Garcia-Perciante, Ana Laura; Sandoval-Villalbazo, Alfredo

    2001-01-01

    Maxwell's equations can be obtained in generalized coordinates by considering the electromagnetic field as an external agent. The work here presented shows how to obtain the electrodynamics for a charged particle in generalized coordinates eliminating the concept of external force. Based on Kaluza's formalism, the one here presented extends the 5x5 metric into a 6x6 space-time giving enough room to include magnetic monopoles in a very natural way.

  7. Coordinated Design In Urban Environments

    OpenAIRE

    KAMALI, Fereshteh Pashaei; RAZMGIR, Akramalsadat; KHOBRO, Babaksimintan; BARADARAN, Alireza Ghandriz

    2015-01-01

    Abstract. In a society in which accepting sociability, consensus and collective product are emphasized, new buildings try to coordinate themselves with the existing patterns. Edmund Bacon (1979) has searched the formation of urban landscape coordinated with manner of relation in which architects have worked in one place but in different times and by stating,the second person’s theory, emphasized that the second designer determines that whether the first architectural work is valuable or recog...

  8. Currency Areas and Monetary Coordination

    OpenAIRE

    Qing Liu; Shouyong Shi

    2006-01-01

    In this paper we integrate the recent development in monetary theory with international finance, in order to examine the coordination between two currency areas in setting long-run inflation. The model determines the value of each currency and the size of each currency area without requiring buyers to use a particular currency to buy a country's goods. We show that the two countries inflate above the Friedman rule in a non-cooperative game. Coordination between the two areas reduces inflation...

  9. Coordination Demands of International Strategies

    OpenAIRE

    Jon I Martinez; J Carlos Jarillo

    1991-01-01

    A study of fifty subsidiaries of Multinational Corporations shows a connection between their strategy and their use of different mechanisms of coordination. The main finding is that subsidiaries pursuing strategies with a high degree of integration with their corporate parent make a much more extensive use of both “formal” and “subtle” coordination mechanisms than other firms in the sample. These results are borne out in both static and dynamic tests. They confirm previous literature on coord...

  10. Consumption externalities, coordination and advertising

    OpenAIRE

    Pastine, Tuvana; Pastine, Ivan

    2001-01-01

    The aim of this Paper is to demonstrate that advertising can have an important function in markets with consumption externalities, apart from its persuasive and informative roles. We show that advertising may function as a device to coordinate consumer expectations of the purchasing decisions of other consumers in markets with consumption externalities. The implications of advertising as a coordinating device are examined in the pricing and advertising decisions of firms interacting strategic...

  11. Comsumption Externalities, Coordination, and Advertising

    OpenAIRE

    Ivan Pastine; Tuvana Pastine

    2002-01-01

    The aim of this article is to demonstrate that advertising can have an important function in markets with consumption externalities apart from its persuasive and informative roles. We show that advertising may function as a device to coordinate consumer expectations of the purchasing decisions of other consumers in markets with consumption externalities. The implications of advertising as a coordinating device are examined in the pricing and advertising decisions of firms interacting strategi...

  12. Co-ordination and specialisation

    OpenAIRE

    Egidi, Massimo; Ricottilli, Massimo

    1997-01-01

    This paper addresses the problem of division of labour as an evolutionary process in which co-ordinated agents attempt problem-solving as a search in problem space. Co-ordination stress and learning trigger adaptation but as complexity rises radical solutions are sought prompting radical organisational as well as technological change. The analytical issues involved are further explored by resorting to the so-called NKC model of evolution and co-evolution.

  13. Dynamic coordination via organizational routines

    OpenAIRE

    Blume, Andreas; April M. Franco; Heidhues, Paul

    2011-01-01

    We investigate dynamic coordination among members of a problem solving team who receive private signals about which of their actions are required for a (static) coordinated solution and who have repeated opportunities to explore different action combinations. In this environment ordinal equilibria, in which agents condition only on how their signals rank their actions and not on signal strength, lead to simple patterns of behavior that have a natural interpretation as routines. These routine ...

  14. DEVELOPMENTAL COORDINATION DISORDER IN CHILDREN

    OpenAIRE

    Saeideh MIRAFKHAMI; Seyyed Hossein FAKHRAEE; Sina MIRAFKHAMI; Mojtaba YOUSEFI; Mona VARZANDEH FAR

    2010-01-01

    ObjectiveIn this article, a motor skill disorder called developmental coordination disorder (DCD), that is usually first diagnosed during childhood, is explained and discussed. In the year 1987, DCD was formally recognized as a distinct disorder in children by the American Psychiatric Association  (APA). DCD is a generalized term for the children who have some degrees of impairment in the development of motor coordination and therefore have difficulties with physical skills which significantl...

  15. On the relativistic Vlasov equation in guiding-center coordinates

    International Nuclear Information System (INIS)

    The relativistic Vlasov equation has been expressed in terms of the guiding-center coordinates in a hot magnetized plasma. It is noted that the relativistic effect reduces the cyclotron resonance frequency for electrostatic and electromagnetic waves propagating transverse to the direction of the static magnetic field in the plasma. (author). 4 refs

  16. The inertia system coordinate transformation based on the Lobachevsky function

    International Nuclear Information System (INIS)

    Based on the interpretation of the Lobachevsky function cosΠ(ρ/k) = thρ/k as the function which expresses the constant light velocity principle at k = c (k is the Lobachevsky constant, c is the light velocity), the inertia system coordinate transformation of two kinds (one of them known as Lorentz transformation) have been obtained

  17. Coordination and Human Resource Planning in the Hawaii Visitor Industry.

    Science.gov (United States)

    Hawaii State Commission on Manpower and Full Employment, Honolulu.

    This report was undertaken in response to a request by the Sixth Legislature, which expressed its concern with the lack of coordination and overall human resource planning in the visitor industry and that the findings of the January 6-7, 1970 Travel Industry Congress had not been fully implemented. The State Commission on Manpower and Full…

  18. Vascular gene expression: a hypothesis

    OpenAIRE

    Martínez-Navarro, Angélica C.; Galván-Gordillo, Santiago V.; Xoconostle-Cázares, Beatriz; Ruiz-Medrano, Roberto

    2013-01-01

    The phloem is the conduit through which photoassimilates are distributed from autotrophic to heterotrophic tissues and is involved in the distribution of signaling molecules that coordinate plant growth and responses to the environment. Phloem function depends on the coordinate expression of a large array of genes. We have previously identified conserved motifs in upstream regions of the Arabidopsis genes, encoding the homologs of pumpkin phloem sap mRNAs, displaying expression in vascular ti...

  19. 78 FR 44519 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-07-24

    ... Office of the Secretary Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice; Re-establishment of the Forest Resource Coordinating Committee and call for nominations. SUMMARY: The Department of Agriculture re-established the Forest Resource Coordinating Committee...

  20. 78 FR 34035 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-06-06

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Forest Resource Coordinating Committee will meet via teleconference every month on... conference call will be posted to the Forest Resource Coordinating Committee Web site,...

  1. Coordination of plant mitochondrial biogenesis: keeping pace with cellular requirements.

    Directory of Open Access Journals (Sweden)

    Elina eWelchen

    2014-01-01

    Full Text Available Plant mitochondria are complex organelles that carry out numerous metabolic processes related with the generation of energy for cellular functions and the synthesis and degradation of several compounds. Mitochondria are semiautonomous and dynamic organelles changing in shape, number and composition depending on tissue or developmental stage. The biogenesis of functional mitochondria requires the coordination of genes present both in the nucleus and the organelle. In addition, due to their central role, all processes held inside mitochondria must be finely coordinated with those in other organelles according to cellular demands. Coordination is achieved by transcriptional control of nuclear genes encoding mitochondrial proteins by specific transcription factors that recognize conserved elements in their promoter regions. In turn, the expression of most of these transcription factors is linked to developmental and environmental cues, according to the availability of nutrients, light-dark cycles and warning signals generated in response to stress conditions. Among the signals impacting in the expression of nuclear genes, retrograde signals that originate inside mitochondria help to adjust mitochondrial biogenesis to organelle demands. Adding more complexity, several nuclear encoded proteins are dual localized to mitochondria and either chloroplasts or the nucleus. Dual targeting might establish a crosstalk between the nucleus and cell organelles to ensure a fine coordination of cellular activities. In this article, we discuss how the different levels of coordination of mitochondrial biogenesis interconnect to optimize the function of the organelle according to both internal and external demands.

  2. Cation coordination in oxychloride glasses

    Science.gov (United States)

    Johnson, J. A.; Holland, D.; Bland, J.; Johnson, C. E.; Thomas, M. F.

    2003-02-01

    Glasses containing mixtures of cations and anions of nominal compositions [Sb2O3]x - [ZnCl2]1-x where x = 0.25, 0.50, 0.75, and 1.00, have been studied by means of neutron diffraction and Raman and Mössbauer spectroscopy. There is preferential bonding within the system with the absence of Sb-Cl bonds. Antimony is found to be threefold coordinated to oxygen, and zinc fourfold coordinated. The main contributing species are of the form [Sb(OSb)2(OZn)] and [Zn(ClZn)2(OSb)2].

  3. Cation coordination in oxychloride glasses

    International Nuclear Information System (INIS)

    Glasses containing mixtures of cations and anions of nominal compositions [Sb2O3]x - [ZnCl2]1-x where x = 0.25, 0.50, 0.75, and 1.00, have been studied by means of neutron diffraction and Raman and Moessbauer spectroscopy. There is preferential bonding within the system with the absence of Sb-Cl bonds. Antimony is found to be threefold coordinated to oxygen, and zinc fourfold coordinated. The main contributing species are of the form [Sb(OSb)2(OZn)] and [Zn(ClZn)2(OSb)2

  4. Cation coordination in oxychloride glasses

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, J A [Energy Technology Division, Argonne National Laboratory, Argonne, IL (United States); Holland, D [Physics Department, Warwick University, Coventry (United Kingdom); Bland, J [Physics Department, University of Liverpool, PO Box 147, Liverpool (United Kingdom); Johnson, C E [Physics Department, Northern Illinois University, DeKalb, IL (United States); Thomas, M F [Physics Department, University of Liverpool, PO Box 147, Liverpool (United Kingdom)

    2003-02-19

    Glasses containing mixtures of cations and anions of nominal compositions [Sb{sub 2}O{sub 3}]{sub x} - [ZnCl{sub 2}]{sub 1-x} where x = 0.25, 0.50, 0.75, and 1.00, have been studied by means of neutron diffraction and Raman and Moessbauer spectroscopy. There is preferential bonding within the system with the absence of Sb-Cl bonds. Antimony is found to be threefold coordinated to oxygen, and zinc fourfold coordinated. The main contributing species are of the form [Sb(OSb){sub 2}(OZn)] and [Zn(ClZn){sub 2}(OSb){sub 2}].

  5. COCO: Conversion of Celestial Coordinates

    Science.gov (United States)

    Wallace, Patrick

    2014-06-01

    The COCO program converts star coordinates from one system to another. Both the improved IAU system, post-1976, and the old pre-1976 system are supported. COCO can perform accurate transformations between multiple coordinate systems. COCO's user-interface is spartan but efficient and the program offers control over report resolution. All input is free-format, and defaults are provided where this is meaningful. COCO uses SLALIB (ascl:1403.025) and is distributed as part of the Starlink software collection (ascl:1110.012).

  6. Anchoring in a novel bimanual coordination pattern.

    Science.gov (United States)

    Maslovat, Dana; Lam, Melanie Y; Brunke, Kirstin M; Chua, Romeo; Franks, Ian M

    2009-02-01

    Anchoring in cyclical movements has been defined as regions of reduced spatial or temporal variability [Beek, P. J. (1989). Juggling dynamics. PhD thesis. Amsterdam: Free University Press] that are typically found at movement reversal points. For in-phase and anti-phase movements, synchronizing reversal points with a metronome pulse has resulted in decreased anchor point variability and increased pattern stability [Byblow, W. D., Carson, R. G., & Goodman, D. (1994). Expressions of asymmetries and anchoring in bimanual coordination. Human Movement Science, 13, 3-28; Fink, P. W., Foo, P., Jirsa, V. K., & Kelso, J. A. S. (2000). Local and global stabilization of coordination by sensory information. Experimental Brain Research, 134, 9-20]. The present experiment examined anchoring during acquisition, retention, and transfer of a 90 degrees phase-offset continuous bimanual coordination pattern (whereby the right limb lags the left limb by one quarter cycle), involving horizontal flexion about the elbow. Three metronome synchronization strategies were imposed: participants either synchronized maximal flexion of the right arm (i.e., single metronome), both flexion and extension of the right arm (i.e., double metronome within-limb), or flexion of each arm (i.e., double metronome between-limb) to an auditory metronome. In contrast to simpler in-phase and anti-phase movements, synchronization of additional reversal points to the metronome did not reduce reversal point variability or increase pattern stability. Furthermore, practicing under different metronome synchronization strategies did not appear to have a significant effect on the rate of acquisition of the pattern. PMID:18842313

  7. (Coordinated research on fuel cycle cost)

    Energy Technology Data Exchange (ETDEWEB)

    Cantor, R.A.; Shelton, R.B.; Krupnick, A.J.

    1990-11-05

    The Department of Energy (DOE) and the Commission of the European Communities (CEC) have been exploring the possibility of parallel studies on the externals costs of employing fuel cycles to deliver energy services. These studies are of particular importance following the activities of the US National Energy Strategy (NES), where the potential discrepancies between market prices and the social costs of energy services were raised as significant policy concerns. To respond to these concerns, Oak Ridge National Laboratory (ORNL) and Resources for the Future (RFF) have begun a collaborative effort for the DOE to investigate the external costs, or externalities, generated by cradle to grave fuel cycle activities. Upon initiating this project, the CEC expressed an interest to the DOE that Europe should conduct a parallel study and that the two studies should be highly coordinated for consistency in the results. This series of meetings with members of the CEC was undertaken to resolve some issues implied by pursuing parallel, coordinated studies; issues that were previously defined by the August meetings. In addition, it was an opportunity for some members of the US research team and the DOE sponsor to meet with their European counterparts for the study, as well as persons in charge of research areas that ultimately would play a key role in the European study.

  8. The circadian clock coordinates ribosome biogenesis.

    Directory of Open Access Journals (Sweden)

    Céline Jouffe

    Full Text Available Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. Moreover, the circadian oscillator directly regulates the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis.

  9. Modelling coordination in biological systems

    NARCIS (Netherlands)

    Clarke, D.G.; Oliveira Costa, D.F. de; Arbab, F.

    2004-01-01

    We present an application of the Reo coordination paradigm to provide a compositional formal model for describing and reasoning about the behaviour of biological systems, such as regulatory gene networks. Reo governs the interaction and flow of data between components by allowing the construction of

  10. Coordinate Geometric Approach to Spherometer

    CERN Document Server

    Khan, Sameen Ahmed

    2013-01-01

    The spherometer used for measuring radius of curvature of spherical surfaces is explicitly based on a geometric relation unique to circles and spheres. We present an alternate approach using coordinate geometry, which reproduces the well-known result for the spherometer and also leads to a scheme to study aspherical surfaces. We shall also briefly describe some of the modified spherometers.

  11. Coordinating talk and practical action

    DEFF Research Database (Denmark)

    Oshima, Sae; Streeck, Jürgen

    2015-01-01

    This paper investigates how talk and practical action are coordinated during one type of activity involving professional communication: the service-assessment sequence in hair salons. During this activity, a practical inspection of the haircut must be coupled with sequentially produced verbal acts...

  12. Information Sharing for Care Coordination

    OpenAIRE

    Amir, Ofra; Grosz, Barbara J.; Stern, Roni; Sanders, Lee M.

    2013-01-01

    Teamwork and care coordination are of increasing importance to health care delivery and patient safety and health. This paper describes our initial work on developing agents that are able to make intelligent information sharing decisions to support a diverse, evolving team of care providers in constructing and maintaining a shared plan that operates in uncertain environments and over a long time horizon.

  13. [Coordination in oncology, pivot nurses].

    Science.gov (United States)

    Feld, Dominique

    2016-06-01

    The function of the pivot nurse was created when the Cancer Plans were first introduced to improve patient management and has constantly developed since then. It is an essential role for the coordination of care and the different players involved along the patient's care pathway. PMID:27338685

  14. Maturation of coordinated IEG expression by cocaine during adolescence

    OpenAIRE

    Caster, Joseph M.; Kuhn, Cynthia M.

    2009-01-01

    Adolescence may be critical period for drug addiction. Young adolescent male rats have greater locomotor responses than adults after acute low dose cocaine administration. Further, repeated cocaine administration produces as much or more conditioned place preference but reduced locomotor sensitization in adolescents compared to adults. Acute activation of neurons by cocaine induces long-term changes in behavior by activating transcriptional complexes. The purpose of the present study was to c...

  15. The potential roles of T-type Ca2+ channels in motor coordination

    Directory of Open Access Journals (Sweden)

    Young-Gyun ePark

    2013-10-01

    Full Text Available Specific behavioral patterns are expressed by complex combinations of muscle coordination. Tremors are simple behavioral patterns and are the focus of studies investigating motor coordination mechanisms in the brain. T-type Ca2+ channels mediate intrinsic neuronal oscillations and rhythmic burst spiking, and facilitate the generation of tremor rhythms in motor circuits. Despite substantial evidence that T-type Ca2+ channels mediate pathological tremors, their roles in physiological motor coordination and behavior remain unknown. Here, we review recent progress in understanding the roles that T-type Ca2+ channels play under pathological conditions, and discuss the potential relevance of these channels in mediating physiological motor coordination.

  16. General coordinate invariance in quantum many-body systems

    CERN Document Server

    Brauner, Tomas; Monin, Alexander; Penco, Riccardo

    2014-01-01

    We extend the notion of general coordinate invariance to many-body, not necessarily relativistic, systems. As an application, we investigate nonrelativistic general covariance in Galilei-invariant systems. The peculiar transformation rules for the background metric and gauge fields, first introduced by Son and Wingate in 2005 and refined in subsequent works, follow naturally from our framework. Our approach makes it clear that Galilei or Poincare symmetry is by no means a necessary prerequisite for making the theory invariant under coordinate diffeomorphisms. General covariance merely expresses the freedom to choose spacetime coordinates at will, whereas the true, physical symmetries of the system can be separately implemented as "internal" symmetries within the vielbein formalism. A systematic way to implement such symmetries is provided by the coset construction. We illustrate this point by applying our formalism to nonrelativistic s-wave superfluids.

  17. A Multi-Leveled Coordinate for Multibody Mechanics

    Directory of Open Access Journals (Sweden)

    Shen Fan

    2016-01-01

    Full Text Available For a proper way of modelling and simulation, as well as the precise and completeness, and a new multi-level method named homogeneous tensor coordinate(HTC was developed by improving the absolute nodal coordinate formulation(ANCF and the homogeneous coordinates(HC. In HTC, a new form of 2×2 matrix was employed instead of angles, when the capacity of expression and calculation was increased at the same time. HTC has good performance in traditional rigid body mechanics, which especially suitable for multibody modelling. Therefore, the robotic engineering may benefit from this finding, and a new formulation for scientific research may also affect the physics although some mathematical problems are raised in matrix theory.

  18. Managing Coordinator, Educational or Entrepreneurial Coordinator: Course Coordinator Profile Analysis at Private HEIS

    Directory of Open Access Journals (Sweden)

    Mariana Augusta de Araújo Silva

    2014-12-01

    Full Text Available Higher Education dynamics is impacted by political, economic and financial interference. In parallel, the Ministry of Education and Culture (MEC is strict in its reviews to ensure Brazilian higher education is appreciated and promoted. The purpose of this study is to identify the profile of Course Coordinators and factors that might improve, at the surveyed HEIs, this professional´s relationship with students, teaching staff and Directors. Literature was searched and reviewed so as to collect subject matter pertaining issues. A quantitative research approach was employed and objectives were of exploratory descriptive nature since this technique ensures extended comprehension of the investigated phenomenon, whilst data was gathered via personal interviews. The object of investigation comprised all Course Coordinators of the Estácio/Natal Group in Brazil´s four units. The survey´s tool comprises: 13 closed questions to identify the Coordinator´s profile; 17 questions with a 5 point Likert score scale to identify the entrepreneurial profile; 42 also resorting to a 5 point Likert score scale to measure the dimensions of the Coordinator´s activities and 4 open, optional questions to measure difficulties and possibilities that impact the development of an entrepreneurial course management approach. The study employed both a statistical method (data analysis and descriptive statistics. Findings lead to the conclusion that information and knowledge gathered support researched HEIs in their overcoming of challenges, amongst which encouraging strategic course management and innovation, focused on implementing a new vision of the Course Coordinator, as professionals that master how to balance management and pedagogical skills, whilst innovating by resorting to entrepreneurial competencies.

  19. A coordination theory for intelligent machines

    Science.gov (United States)

    Wang, Fei-Yue; Saridis, George N.

    1990-01-01

    A formal model for the coordination level of intelligent machines is established. The framework of the coordination level investigated consists of one dispatcher and a number of coordinators. The model called coordination structure has been used to describe analytically the information structure and information flow for the coordination activities in the coordination level. Specifically, the coordination structure offers a formalism to (1) describe the task translation of the dispatcher and coordinators; (2) represent the individual process within the dispatcher and coordinators; (3) specify the cooperation and connection among the dispatcher and coordinators; (4) perform the process analysis and evaluation; and (5) provide a control and communication mechanism for the real-time monitor or simulation of the coordination process. A simple procedure for the task scheduling in the coordination structure is presented. The task translation is achieved by a stochastic learning algorithm. The learning process is measured with entropy and its convergence is guaranteed. Finally, a case study of the coordination structure with three coordinators and one dispatcher for a simple intelligent manipulator system illustrates the proposed model and the simulation of the task processes performed on the model verifies the soundness of the theory.

  20. Supply Chain Reorganization and Coordination

    Institute of Scientific and Technical Information of China (English)

    WANG Feng-bin

    2001-01-01

    Three generic forms of governance--hierarchy, hybrid and market are proposed in the newinstitutional economics, giving an abstract description of alternative coordination and control mechanisms forgeneral use. While this theory is known as far away from being operational and specified, a few researchersin the management and organization area are trying to extend Galbraith and/or Mintzberg's organizationaldesign theories into the application of logistical coordination for obtaining a smooth flow of products along thesupply chain within and without the focal organization. In this paper, we present an explorative case study onthe design of various organizational architectures of logistics activities and their relevant coordinationmechanisms, especially internal and external contracts as one new kind of hybrid mechanisms forcoordinating effective supply chains.

  1. Modelling coordination in biological systems

    OpenAIRE

    Clarke, David; Oliveira Costa, de, David; Arbab, Farhad

    2004-01-01

    We present an application of the Reo coordination paradigm to provide a compositional formal model for describing and reasoning about the behaviour of biological systems, such as regulatory gene networks. Reo governs the interaction and flow of data between components by allowing the construction of connector circuits which have a precise formal semantics. When applied to systems biology, the result is a graphical model, which is comprehensible, mathematically precise, and flexible

  2. Coordinating sensing and local navigation

    Science.gov (United States)

    Slack, Marc G.

    1991-07-01

    Based on Navigation Templates (or NaTs), this work presents a new paradigm for local navigation which addresses the noisy and uncertain nature of sensor data. Rather than creating a new navigation plan each time the robot's perception of the world changes, the technique incorporates perceptual changes directly into the existing navigation plan. In this way, the robot's navigation plan is quickly and continuously modified, resulting in actions that remain coordinated with its changing perception of the world.

  3. A Classroom Investment Coordination Experiment

    OpenAIRE

    Denise Hazlett

    2007-01-01

    In this classroom experiment students represent firms that make investment decisions. They play a repeated game with each firm privately choosing its level of investment. Participating in the experiment helps students understand theories that posit coordination failure as the cause of economic fluctuations. Students see that when firms expect a recession, their resulting low levels of investment actually cause a recession. Likewise, when firms expect an expansion, their resulting high levels ...

  4. Coordination of traffic lights evaluation

    OpenAIRE

    Ordeig Vila, Enric

    2012-01-01

    This case study consists in the evaluation of the Kaunas city traffic speed taking into consideration that traffic lights were coordinated. Kaunas suffers from high traffic intensity and, as a consequence, traffic jams often, and happens mainly because the city can only be crossed by the center. Lithuania, as the rest of Europe experienced a big growth, from 1995 to 2005 coinciding with the crisis, that is to say that number of cars increased to highest levels as well as the ...

  5. DEVELOPMENTAL COORDINATION DISORDER IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Saeideh MIRAFKHAMI

    2010-04-01

    Full Text Available ObjectiveIn this article, a motor skill disorder called developmental coordination disorder (DCD, that is usually first diagnosed during childhood, is explained and discussed. In the year 1987, DCD was formally recognized as a distinct disorder in children by the American Psychiatric Association  (APA. DCD is a generalized term for the children who have some degrees of impairment in the development of motor coordination and therefore have difficulties with physical skills which significantly interfere with their academic achievements and /or performing everyday activities. As they develop, other age-related tasks are also below average. Because these impairment & conditions are often associated with emotional distress, they can seriously interfere with the person's everyday life and social relationships. Reviews indicate that most of the training rocedures have only a limited effect on the development of general coordination, and that they have no effect at all on academic progress.This includes approaches based on assumed underlying deficiencies such as sensory integration deficits and kinesthetic functioning deficits, as well as the more traditional perceptual - motor training. One new approach is Cognitive Orientation to daily Occupational Performance (CO-OP, based on problem - solving strategies and guided discovery of the child and task specific strategies. The aim of this article was to inform, promote and disseminate more information about some difficulties in applying the diagnostic criteria for DCD. Also, a brief review of the researches on the intervention methods is presented.Keywords: Developmental coordination disorder, Motor skills disorder, Childhood disorder, Intervention methods

  6. Relative observability in coordination control

    Czech Academy of Sciences Publication Activity Database

    Komenda, Jan; Masopust, Tomáš; van Schuppen, J. H.

    Piscataway: IEEE, 2015 - (Lennartson, B.), s. 75-80 ISBN 978-1-4673-8182-6. [IEEE International Conference on Automation Science and Engineering (CASE), 2015. Gothenburg (SE), 24.08.2015-28.08.2015] R&D Projects: GA MŠk LH13012; GA ČR GA15-02532S Institutional support: RVO:67985840 Keywords : supervisory control * coordination control * relative observability Subject RIV: BA - General Mathematics http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7294044

  7. Multirobot Coordination for Space Exploration

    OpenAIRE

    Yliniemi, Logan; Oregon State University; Agogino, Adrian K.; Tumer, Kagan; Oregon State University

    2014-01-01

    Teams of artificially intelligent planetary rovers have tremendous potential for space exploration, allowing for reduced cost, increased flexibility and increased reliability. However, having these multiple autonomous devices acting simultaneously leads to a problem of coordination: to achieve the best results, the they should work together. This is not a simple task. Due to the large distances and harsh environments, a rover must be able to perform a wide variety of tasks with a wide variety...

  8. Measuring Motor Coordination in Mice

    OpenAIRE

    Deacon, Robert M.J.

    2013-01-01

    Mice are increasingly being used in behavioral neuroscience, largely replacing rats as the behaviorist's animal of choice. Before aspects of behavior such as emotionality or cognition can be assessed, however, it is vital to determine whether the motor capabilities of e.g. a mutant or lesioned mouse allow such an assessment. Performance on a maze task requiring strength and coordination, such as the Morris water maze, might well be impaired in a mouse by motor, rather than cognitive, impairme...

  9. Equatorially coordinated lanthanide single ion magnets.

    Science.gov (United States)

    Zhang, Peng; Zhang, Li; Wang, Chao; Xue, Shufang; Lin, Shuang-Yan; Tang, Jinkui

    2014-03-26

    The magnetic relaxation dynamics of low-coordinate Dy(III) and Er(III) complexes, namely three-coordinate ones with an equatorially coordinated triangle geometry and five-coordinate ones with a trigonal bipyramidal geometry, have been exploited for the first time. The three-coordinate Er-based complex is the first equatorially coordinated mononuclear Er-based single-molecule magnet (SMM) corroborating that simple models can effectively direct the design of target SMMs incorporating 4f-elements. PMID:24625001

  10. Porphyrin coordination polymer nanospheres and nanorods

    Science.gov (United States)

    Wang, Zhongchun; Shelnutt, John A.; Medforth, Craig J.

    2012-12-04

    A porphyrin coordination polymer nanostructure comprising a network of pyridyl porphyrin molecules and coordinating metal ions coordinatively bound through the pyridyl groups. In some embodiments, the porphyrins are metalloporphyrins. A variety of nanostructures are formed by the network polymer, including nanospheres, polygonal nanostructures, nanorods, and nanofibers, depending on a variety of factors including coordination metal ion, porphyrin type, metal of the metalloporphyrin, and degree of agitation during nanostructure formation. Reduction of coordinating metal ions may be used to form metal nanoparticles on the coordination polymer nanostructure.

  11. Fermi coordinates and Penrose limits

    Energy Technology Data Exchange (ETDEWEB)

    Blau, Matthias; Frank, Denis; Weiss, Sebastian [Institut de Physique, Universite de Neuchatel Rue Breguet 1, CH-2000 Neuchatel (Switzerland)

    2006-06-07

    We propose a formulation of the Penrose plane wave limit in terms of null Fermi coordinates. This provides a physically intuitive (Fermi coordinates are direct measures of geodesic distance in spacetime) and manifestly covariant description of the expansion around the plane wave metric in terms of components of the curvature tensor of the original metric, and generalizes the covariant description of the lowest order Penrose limit metric itself, obtained in Blau et al (2004 Class. Quantum Grav. 21 L43-9). We describe in some detail the construction of null Fermi coordinates and the corresponding expansion of the metric, and then study various aspects of the higher order corrections to the Penrose limit. In particular, we observe that in general the first-order corrected metric is such that it admits a light-cone gauge description in string theory. We also establish a formal analogue of the Weyl tensor peeling theorem for the Penrose limit expansion in any dimension, and we give a simple derivation of the leading (quadratic) corrections to the Penrose limit of AdS{sub 5} x S{sup 5}.

  12. DEVELOPMENTAL COORDINATION DISORDER IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Saeideh MIRAFKHAMI

    2010-03-01

    Full Text Available ObjectiveIn this article, a motor skill disorder called developmental coordination disorder (DCD, that is usually first diagnosed during childhood, is explained and discussed. In the year 1987, DCD was formally recognized as a distinct disorder in children by the American Psychiatric Association (APA. DCD is a generalized term for the children who have some degrees of impairment in the development of motor coordination and therefore have difficulties with physical skills which significantly interfere with their academic achievements and /or performing everyday activities. As they develop, other age-related tasks are also below average. Because these impairment & conditions are often associated with emotional distress, they can seriously interfere with the person's everyday life and social relationships. Reviews indicate that most of the training rocedures have only a limited effect on the development of general coordination, and that they have no effect at all on academic progress.This includes approaches based on assumed underlying deficiencies such as sensory integration deficits and kinesthetic functioning deficits, as well as the more traditional perceptual - motor training. One new approach is Cognitive Orientation to daily Occupational Performance (CO-OP, based on problem - solving strategies and guided discovery of the child and task specific strategies. The aim of this article was to inform, promote and disseminate more information about some difficulties in applying the diagnostic criteria for DCD. Also, a brief review of the researches on the intervention methods is presented.

  13. Coordinated parallelizing compiler optimizations and high-level synthesis

    OpenAIRE

    S Gupta; Gupta, R. K.; Dutt, N D; Nicolau, A.

    2004-01-01

    We present a high-level synthesis methodology that applies a coordinated set of coarse-grain and fine-grain parallelizing transformations. The transformations are applied both during a presynthesis phase and during scheduling, with the objective of optimizing the results of synthesis and reducing the impact of control flow constructs on the quality of results. We first apply a set of source level presynthesis transformations that include common sub-expression elimination (CSE), copy propagati...

  14. Deciphering transcriptional regulations coordinating the response to environmental changes

    OpenAIRE

    Acuña, Vicente; Aravena, Andrés; Guziolowski, Carito; Eveillard, Damien; Siegel, Anne; Maass, Alejandro

    2016-01-01

    Background Gene co-expression evidenced as a response to environmental changes has shown that transcriptional activity is coordinated, which pinpoints the role of transcriptional regulatory networks (TRNs). Nevertheless, the prediction of TRNs based on the affinity of transcription factors (TFs) with binding sites (BSs) generally produces an over-estimation of the observable TF/BS relations within the network and therefore many of the predicted relations are spurious. Results We present Lomba...

  15. N = 4 Superfiel Phase Space Coordinates and Hamiltonian Quantization

    OpenAIRE

    Assaoui, F.; Lhallabi, T.

    2007-01-01

    The N = 4 superfield phase space coordinates are given in the harmonic superspace. The expressions of the N = 4 classical equations of motion are determined in terms of the spinorial and harmonic supercharges. Furthermore, the N = 4 supersymmetric actions are obtained by means of the fermionic and harmonic functionals. On the other hand, the Hamiltonian quantization is studied by performing the N = 4 supersymmetric action in harmonic subspace in terms of analytic N = 4 superfield phase space ...

  16. The Imperative for Improved Global Economic Coordination

    OpenAIRE

    Stiglitz, Joseph E.

    2009-01-01

    While global coordination is absolutely essential, success in achieving it may prove difficult because economic globalization has outpaced political globalization. If we are to succeed, we will have to manage coordination better than we have in the past.

  17. 78 FR 57128 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-09-17

    ... assistance delivery systems, forest inventory and analysis, markets, climate change adaptation, forest... Program Coordinator, Cooperative Forestry Staff, 202-205-1376 or Ted Beauvais, Forest Resource Coordinating Committee Designated Federal Officer, Cooperative Forestry Staff, 202-205-1190. Individuals...

  18. Regulatory Coordination between Two Major Intracellular Homeostatic Systems

    DEFF Research Database (Denmark)

    Dokladny, Karol; Zuhl, Micah Nathaniel; Mandell, Michael;

    2013-01-01

    expression of its ATPase mutant inhibited starvation or rapamycin-induced autophagy. We also show that exercise induces autophagy in humans. As predicted by our in vitro studies, glutamine supplementation as a conditioning stimulus prior to exercise significantly increased HSP70 protein expression and...... prevented the expected exercise induction of autophagy. Our data demonstrate for the first time that heat shock response, from the top of its regulatory cascade (HSF-1) down to the execution stages delivered by HSP70, controls autophagy thus connecting and coordinating the two extreme ends of the...

  19. Parenting Coordinators' Practices Recommendations: A Qualitative Study

    OpenAIRE

    Hirsch, Barbara Phyllis

    2016-01-01

    This qualitative study used a phenomenological approach to understand the experiences of seven parenting coordinators in using parenting coordination practices that they have found to be effective and would recommend to other parenting coordinators to achieve the following goals: educating parents, increasing the quality of parenting and co-parenting, managing conflict, and involving children and other family members in the process of parenting coordination. Data were collected with semi-str...

  20. Kerr metric, static observers and Fermi coordinates

    International Nuclear Information System (INIS)

    The coordinate transformation which maps the Kerr metric written in standard Boyer-Lindquist coordinates to its corresponding form adapted to the natural local coordinates of an observer at rest at a fixed position in the equatorial plane, i.e., Fermi coordinates for the neighbourhood of a static observer world line, is derived and discussed in a way which extends to any uniformly circularly orbiting observer there

  1. Coordination in humanitarian logistics through clusters

    OpenAIRE

    Jahre, Marianne; Jensen, Leif-Magnus

    2010-01-01

    Purpose – In the field of humanitarianism, cluster thinking has been suggested as a solution to the lack of coordinated disaster response. Clusters for diverse functions, including sheltering, logistics and water and sanitation, can be viewed as an effort to achieve functional coordination. The purpose of this paper is to contribute to a greater understanding of the potential of cluster concepts using supply chain coordination and inter‐cluster coordination. The focus is on the conceptual lev...

  2. Coordination: Theoretical, Methodological, and Experimental Perspectives

    OpenAIRE

    Paxton, Alexandra

    2015-01-01

    Interpersonal coordination broadly captures the ways in which interacting individuals become more similar over time in their behavior, cognition, and affect over time. The research area around interpersonal coordination is poised to yield unique insights into questions of human communication, interaction, and social behavior. As a field, interpersonal coordination still has immense room to grow---providing an exciting challenge to interdisciplinary researchers. Interpersonal coordination has ...

  3. Fokker - Planck equation in curvilinear coordinates

    OpenAIRE

    Tanski, Igor A.

    2005-01-01

    The aim of this paper is to rewrite the Fokker - Planck equation according to transformation of space coordinates. This is nontrivial problem, because transformation of space coordinates induces transformation of velocities. We can use covariant, contravariant or physical velocity components as independent variables in curvilinear coordinate system. These 3 possibilities are considered in this paper and 3 kinds of Fokker - Planck equation in curvilinear coordinates are formulated.

  4. 49 CFR 214.325 - Train coordination.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Train coordination. 214.325 Section 214.325..., DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.325 Train coordination. Working limits established by a roadway worker through the use of train coordination shall comply with...

  5. 45 CFR 1310.23 - Coordinated transportation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Coordinated transportation. 1310.23 Section 1310... START PROGRAM HEAD START TRANSPORTATION Special Requirements § 1310.23 Coordinated transportation. (a) Each agency providing transportation services must make reasonable efforts to coordinate...

  6. Managing interteam coordination within and between organizations

    NARCIS (Netherlands)

    de Vries, Thomas Arend

    2015-01-01

    To accomplish complex tasks and effectively respond to environmental contingencies, teams must coordinate task-related issues with other teams (i.e., interteam coordination). Regrettably, interteam coordination is often complicated by misunderstandings that can arise from differences in teams’ langu

  7. Is fiscal policy coordination in EMU desirable?

    NARCIS (Netherlands)

    R.M.W.J. Beetsma; X. Debrun; F.J.G.M. Klaassen

    2001-01-01

    'It is widely argued that Europe's unified monetary policy calls for international coordination of fiscal policy. This paper surveys the issues involved with the coordination of fiscal policies as a demand management tool. We discuss ex-ante and ex-post coordination. The former operates through bind

  8. Coordinated control of HVAC systems

    OpenAIRE

    Federspiel, Clifford C; Lanning, Sasha D; Li, Hulin; David M. Auslander

    2001-01-01

    This paper describes the development of new control logic for starting and stopping energy-intensive equipment in buildings such as staged air-conditioning units. The concept is to use pulse-width modulation (PWM) instead of level-crossing logic. A finite state machine is used to handle the case where a single unit has multiple stages of operation. An optimized coordinator determines the phase of the PWM signals of each unit so that peak demand for power is minimized over each PWM period. Con...

  9. Application coordination in pervasive systems

    CERN Document Server

    Majuntke, Verena Elisabeth

    2013-01-01

    Pervasive applications are designed to support users in their daily life. For this purpose, applications interact with their environment, i.e. their context. They are able to adapt themselves to context changes or to explicitly change the context via actuators. If multiple applications are executed in the same context, interferences are likely to occur. To manage interferences, a coordination framework is presented in this thesis. Interferences are detected using a context model and information about applications' interaction with the context. The resolution of interference is achieved through

  10. Coordinated hybrid automatic repeat request

    KAUST Repository

    Makki, Behrooz

    2014-11-01

    We develop a coordinated hybrid automatic repeat request (HARQ) approach. With the proposed scheme, if a user message is correctly decoded in the first HARQ rounds, its spectrum is allocated to other users, to improve the network outage probability and the users\\' fairness. The results, which are obtained for single- and multiple-antenna setups, demonstrate the efficiency of the proposed approach in different conditions. For instance, with a maximum of M retransmissions and single transmit/receive antennas, the diversity gain of a user increases from M to (J+1)(M-1)+1 where J is the number of users helping that user.

  11. Intelligent navigation and multivehicle coordination

    Science.gov (United States)

    McKay, Mark D.; Anderson, Matthew O.; Kinoshita, Robert A.; Flann, Nicholas S.

    1999-07-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University's Center for Self-Organizing and Intelligent Systems have developed a team of autonomous robotic vehicles. This paper discusses the development of a strategy that uses a sophisticated, highly intelligent sensor platform to allow centralized coordination between smaller and inexpensive robots. The three components of the multi-agent cooperative scheme are small-scale robots, large-scale robots, and the central control station running a mission and path- planning software. The smaller robots are used for activities where the probability of loss increases, such as Unexploded Ordnance (UXO) or mine detonation. The research is aimed at building simple, inexpensive multi-agent vehicles and an intelligent navigation and multi-vehicle coordination system suitable for UXO, environmental remediation or mine detection. These simplified robots are capable of conducting hunting missions using low-cost positioning sensors and intelligent algorithms. Additionally, a larger sensor-rich intelligent system capable of transporting smaller units to outlying remote sites has been developed. The larger system interfaces to the central control station and provides navigation assistance to multiple low-cost vehicles. Finally, mission and path-planning software serves as the operator control unit, allowing central data collection, map creation and tracking, and an interface to the larger system as well as each smaller unit. The power of this scheme is the ability to scale to the appropriate level for the complexity of the mission.

  12. Coordinated research projects (CRP). Coordinated research project (CRP)

    International Nuclear Information System (INIS)

    In the present paper, the contribution of Japanese scientists in coordinated research projects on thermonuclear fusion. Representative subjects taken in seven projects are the precise computation of theoretical data on electron-molecule collisions in the peripheral plasma, the computation of spectroscopic data of multi-charged tungsten ions, the spectroscopic measurement of multi-charged tungsten ions using an ion trap device, the development of collisional-radiative model for plasmas including hydrogen and helium, the computational and theoretical studies on the behavior of tungsten and beryllium in the plasma-wall interaction, the study on the property of dusts generated in fusion devices. These subjects are those of most important issues in ITER. (author)

  13. Collaborative Supply Chain Planning and Coordination

    DEFF Research Database (Denmark)

    Wong, Chee Yew

    strategies between the toy manufacturer and three European retailers. These three case studies provide evidences that the toy manufacturer and the retailers followed some particular patterns of planning coordination processes; they also practised some patterns of coordination behaviour during the...... coordination processes, particularly the behaviour of risk-taking/avoidance, conflict resolutions, and self-interest. All these lead to conclusion of five propositions or principles of supply chain coordination, and the theory of coordination process and behaviour. Combining the propositions of responsiveness......This thesis contains main results from an industrial PhD research in the areas of supply chain strategy, planning, and coordination. It applies the concepts of responsiveness and coordination to reduce mismatch of supply and demand, especially for a volatile and seasonal supply chain. It involves a...

  14. Coordinating International Response to Emergencies

    International Nuclear Information System (INIS)

    Pandemic disease, natural disasters and terrorism can affect thousands of people in a relatively short period of time anywhere in the world. Our recent international experience with hurricanes, earthquakes, tsunamis and infectious diseases (AIDS, TB and highly pathogenic avian influenza) show us that we must respond with a coordinated approach or we will fail the very people we intend to help. Nations from around the world are often eager to send assistance to the site of a disaster, but coordinating the incoming aid is more often flawed and imprecise than it must be in order to save lives and mitigate suffering. How can any one country, suffering from a horrendous calamity coordinate the incoming aid from around the world? Can any one agency hope to coordinate the myriad nation's response let alone that of the hundreds of non-governmental organizations? Currently, the answer is sadly, no. The purpose of this presentation is not to recommend one over the many international bodies which claim to oversee humanitarian assistance; the purpose of this presentation is to discuss the elements of only one aspect of the overall response effort: public health and medical response coordination. Public health response is of course different than a purely medical response. Traditionally, in a natural disaster, immediate public health concerns center around water, sewerage/waste disposal, potential for disease outbreaks, etc, whereas medical response concentrates on triage, saving those who can be saved, patching up the injured, and to a lesser extent, primary care to the survivors. In order to avoid political controversy, this presentation will use the example of Hurricane Iniki in Hawaii, September 1992, to illustrate key concepts. The State of Hawaii is no stranger to natural disasters. Their emergency response mechanisms are well honed, exercised and quite capable. However, the local community leaders on Kauai Island went thru each of the following phases before they

  15. Update on System Coordination Centre

    International Nuclear Information System (INIS)

    The new System Coordination Centre at the Power Pool of Alberta was designed to meet the unique requirements of Alberta's electric industry under the new regulatory regime. Development of the Centre, key provisions of the energy management system (EMS) are highlighted. The centre will provide an energy management system for the Pool's system controller function and interface with the Power Pool Administrator's market functions and the operations of the Transmission Administrator. System controllers are expected to be operating from the new location by the end of 1998. Unique EMS features of the centre include: (1) real-time management of energy market and network operations using diverse SCADA/EMS, (2) inter-control centre protocol used to accommodate the unique participant information requirements, and (3) special custom applications. The Centre is expected to be fully functioning by July 1999. 1 fig

  16. ProC: Process Coordinator

    Science.gov (United States)

    Planck software Team

    2016-01-01

    ProC (short for Process Coordinator) is a versatile workflow engine that allows the user to build, run and manage workflows with just a few clicks. It automatically documents every processing step, making every modification to data reproducible. ProC provides a graphical user interface for constructing complex data processing workflows out of a given set of computer programs. The user can, for example, specify that only data products which are affected by a change in the input data are updated selectively, avoiding unnecessary computations. The ProC suite is flexible and satisfies basic needs of data processing centers that have to be able to restructure their data processing along with the development of a project.

  17. Tree Formation Using Coordinate Method

    Directory of Open Access Journals (Sweden)

    Monika Choudhary

    2015-06-01

    Full Text Available In this paper we are introducing a new method of tree formation, we propose a coordinate based method by which we can store and access tree structures. As we know in NLP, parsing is the most important module. The output of this module is generally parsed trees. Currently, TAG (Tree Adjoining Grammar is widely used grammar due to its linguistic and formal nature. It is simply tree generating system. The unit structure used in TAG is structured trees. So we used our new method to store trees where we worked on English to Hindi language. We worked on different sentences from English to Hindi, our method is the easiest way to manipulate tree. We have implemented within small corpus and for finite number of structures and further can be extended in future.

  18. Coordination Frictions and Job Heterogeneity

    DEFF Research Database (Denmark)

    Kennes, John; le Maire, Christian Daniel

    This paper develops and extends a dynamic, discrete time, job to worker matching model in which jobs are heterogeneous in equilibrium. The key assumptions of this economic environment are (i) matching is directed and (ii) coordination frictions lead to heterogeneous local labor markets. We de- rive...... a number of new theoretical results, which are essential for the empirical application of this type of model to matched employer-employee microdata. First, we o¤er a robust equilibrium concept in which there is a continu- ous dispersion of job productivities and wages. Second, we show that our model...... results preserve the essential tractability of the baseline model with aggregate shocks. Therefore, we o¤er a parsimonious, general equilibrium framework in which to study the process by which the contin- uous dispersion of wages and productivities varies over the business cycle for a large population of...

  19. Wave propagation in complex coordinates

    Science.gov (United States)

    Horsley, S. A. R.; King, C. G.; Philbin, T. G.

    2016-04-01

    We give an interpretation for the use of complex spatial coordinates in electromagnetism, in terms of a family of closely related inhomogeneous media. Using this understanding we find that the phenomenon of reflection can be related to branch cuts in the wave that originate from poles of ε (z) at complex positions. Demanding that these branch cuts disappear, we derive a new large family of inhomogeneous media that are reflectionless for a single angle of incidence. Extending this property to all angles of incidence leads us to a generalized form of the Pöschl Teller potentials that in general include regions of loss and gain. We conclude by analyzing our findings within the phase integral (WKB) method, and find another very large family of isotropic planar media that from one side have a transmission of unity and reflection of zero, for all angles of incidence.

  20. Update on System Coordination Centre

    Energy Technology Data Exchange (ETDEWEB)

    Stangl, W. [Power Pool of Alberta, Calgary, AB (Canada)

    1998-07-01

    The new System Coordination Centre at the Power Pool of Alberta was designed to meet the unique requirements of Alberta`s electric industry under the new regulatory regime. Development of the Centre, key provisions of the energy management system (EMS) are highlighted. The centre will provide an energy management system for the Pool`s system controller function and interface with the Power Pool Administrator`s market functions and the operations of the Transmission Administrator. System controllers are expected to be operating from the new location by the end of 1998. Unique EMS features of the centre include: (1) real-time management of energy market and network operations using diverse SCADA/EMS, (2) inter-control centre protocol used to accommodate the unique participant information requirements, and (3) special custom applications. The Centre is expected to be fully functioning by July 1999. 1 fig.

  1. Coordination control of distributed systems

    CERN Document Server

    Villa, Tiziano

    2015-01-01

    This book describes how control of distributed systems can be advanced by an integration of control, communication, and computation. The global control objectives are met by judicious combinations of local and nonlocal observations taking advantage of various forms of communication exchanges between distributed controllers. Control architectures are considered according to  increasing degrees of cooperation of local controllers:  fully distributed or decentralized control,  control with communication between controllers,  coordination control, and multilevel control.  The book covers also topics bridging computer science, communication, and control, like communication for control of networks, average consensus for distributed systems, and modeling and verification of discrete and of hybrid systems. Examples and case studies are introduced in the first part of the text and developed throughout the book. They include: control of underwater vehicles, automated-guided vehicles on a container terminal, contro...

  2. A mobile-agent-based approach to software coordination inthe HOOPE system

    Institute of Scientific and Technical Information of China (English)

    马晓星; 吕建; 陶先平; 李英军; 胡昊

    2002-01-01

    Software coordination is central to the construction of large-scale high-performance distributed applications with software services scattered over the decentralized Internet. In this paper, a new mobile-agent-based architecture is proposed for the utilization and coordination of geographically distributed computing resources. Under this architecture, a user application is built with a set of software agents that can travel across the network autonomously. These agents utilize the distributed resources and coordinate with each other to complete their task. This approach's advantages include the natural expression and flexible deployment of the coordination logic, the dynamic adaptation to the network environment and the potential of better application performance. This coordination architecture, together with an object-oriented hierarchical parallel application framework and a graphical application construction tool, is implemented in the HOOPE environment, which provides a systematic support for the development and execution of Internet-based distributed and parallel applications in the petroleum exploration industry.

  3. 75 FR 6590 - Coordinated Communications

    Science.gov (United States)

    2010-02-10

    ... Communications, 74 FR 53893 (Oct. 21, 2009). The deadline for comments on the NPRM was January 19, 2010. In the... express advocacy'' test? See, e.g., NPRM, 74 FR at 53902. Should any parts of 11 CFR 114.15 be included in... NPRM, 74 FR at 53903-04 and 53911-12. The Commission also seeks comment on the application of...

  4. Coordination of respiration and swallowing: functional pattern and relevance of vocal folds closure

    OpenAIRE

    Milton Melciades Barbosa Costa; Eponina Maria De Oliveira Lemme

    2010-01-01

    CONTEXT: Breathing and swallowing coordination, despite the expressive number of study, remain as theme deserving further research. OBJECTIVE: To identify a coordination pattern between swallowing and the natural breathing pause that occur in association with it (swallowing apnea) and also the relevance of the vocal folds closure in this process. METHODS: Sixty-six adults, male and female, including normal health people, post-laryngectomy individuals and patients with digestive complaints wit...

  5. Intragenic alternative splicing coordination is essential for Caenorhabditis elegans slo-1 gene function

    OpenAIRE

    Glauser, Dominique A; Johnson, Brandon E.; Aldrich, Richard W; Goodman, Miriam B.

    2012-01-01

    Alternative splicing is critical for diversifying eukaryotic proteomes, but the rules governing and coordinating splicing events among multiple alternate splice sites within individual genes are not well understood. We developed a quantitative PCR-based strategy to quantify the expression of the 12 transcripts encoded by the Caenorhabditis elegans slo-1 gene, containing three alternate splice sites. Using conditional probability-based models, we show that splicing events are coordinated acros...

  6. Coordination of Mathematics and Physical Resources by Physics Graduate Students

    CERN Document Server

    Gupta, Ayush; Hammer, David

    2008-01-01

    We investigate the dynamics of how graduate students coordinate their mathematics and physics knowledge within the context of solving a homework problem for a plasma physics survey course. Students were asked to obtain the complex dielectric function for a plasma with a specified distribution function and find the roots of that expression. While all the 16 participating students obtained the dielectric function correctly in one of two equivalent expressions, roughly half of them (7 of 16) failed to compute the roots correctly. All seven took the same initial step that led them to the incorrect answer. We note a perfect correlation between the specific expression of dielectric function obtained and the student's success in solving for the roots. We analyze student responses in terms of a resources framework and suggest routes for future research.

  7. Photoactive devices including porphyrinoids with coordinating additives

    Energy Technology Data Exchange (ETDEWEB)

    Forrest, Stephen R; Zimmerman, Jeramy; Yu, Eric K; Thompson, Mark E; Trinh, Cong; Whited, Matthew; Diev, Vlacheslav

    2015-05-12

    Coordinating additives are included in porphyrinoid-based materials to promote intermolecular organization and improve one or more photoelectric characteristics of the materials. The coordinating additives are selected from fullerene compounds and organic compounds having free electron pairs. Combinations of different coordinating additives can be used to tailor the characteristic properties of such porphyrinoid-based materials, including porphyrin oligomers. Bidentate ligands are one type of coordinating additive that can form coordination bonds with a central metal ion of two different porphyrinoid compounds to promote porphyrinoid alignment and/or pi-stacking. The coordinating additives can shift the absorption spectrum of a photoactive material toward higher wavelengths, increase the external quantum efficiency of the material, or both.

  8. Control coordination abilities in shock combat sports

    Directory of Open Access Journals (Sweden)

    Natalya Boychenko

    2014-12-01

    Full Text Available Purpose: optimize the process control level of coordination abilities in martial arts. Material and Methods: analysis and compilation of scientific and methodological literature, interviews with coaches of drum martial arts, video analysis techniques, teacher observations. Results: identified specific types of coordination abilities in shock combat sports. Pod branny and offered specific and nonspecific tests to monitor the level of species athletes coordination abilities. Conclusion: it is determined that in order to achieve victory in the fight martial artists to navigate the space to be able to assess and manage dynamic and spatio-temporal parameters of movements, maintain balance, have a high coordination of movements. The proposed tests to monitor species coordination abilities athletes allow an objective assessment of not only the overall level of coordination, and the level of specific types of manifestations of this ability.

  9. Characteristics of Trivalent Lanthanides in Coordination Chemistry

    Institute of Scientific and Technical Information of China (English)

    Xue Dongfeng(薛冬峰); Zuo Sen(左森); Henryk Ratajczak

    2004-01-01

    Some basic characteristics of lanthanide-oxygen bonds in various trivalent lanthanide metal-organic complexes are quantitatively studied by the bond valence model. Some important relationships among the electronegativity, bond valence parameter, bond length and lanthanide coordination number in these complexes are generally found , which show that for each trivalent lanthanide cation all calculated parameters may well be correlated with its coordination number in their coordination complexes. Specifically,32 new data for the bond valence parameter are first calculated in this work.An approximate linear relationship between the Ln-O bond valence parameter and the coordination number of Ln3+ is obtained.The Ln-O bond length increases with the increase in the lanthanide coordination number.The difference of electronegative values decreases with the increase in the lanthanide coordination number.

  10. Reaction Coordinates and Mechanistic Hypothesis Tests.

    Science.gov (United States)

    Peters, Baron

    2016-05-27

    Reaction coordinates are integral to several classic rate theories that can (a) predict kinetic trends across conditions and homologous reactions, (b) extract activation parameters with a clear physical interpretation from experimental rates, and (c) enable efficient calculations of free energy barriers and rates. New trajectory-based rare events methods can provide rates directly from dynamical trajectories without a reaction coordinate. Trajectory-based frameworks can also generate ideal (but abstract) reaction coordinates such as committors and eigenfunctions of the master equation. However, rates and mechanistic insights obtained from trajectory-based methods and abstract coordinates are not readily generalized across simulation conditions or reaction families. We discuss methods for identifying physically meaningful reaction coordinates, including committor analysis, variational transition state theory, Kramers-Langer-Berezhkovskii-Szabo theory, and statistical inference methods that can use path sampling data to screen, mix, and optimize thousands of trial coordinates. Special focus is given to likelihood maximization and inertial likelihood maximization approaches. PMID:27090846

  11. Configuration space representation in parallel coordinates

    Science.gov (United States)

    Fiorini, Paolo; Inselberg, Alfred

    1989-01-01

    By means of a system of parallel coordinates, a nonprojective mapping from R exp N to R squared is obtained for any positive integer N. In this way multivariate data and relations can be represented in the Euclidean plane (embedded in the projective plane). Basically, R squared with Cartesian coordinates is augmented by N parallel axes, one for each variable. The N joint variables of a robotic device can be represented graphically by using parallel coordinates. It is pointed out that some properties of the relation are better perceived visually from the parallel coordinate representation, and that new algorithms and data structures can be obtained from this representation. The main features of parallel coordinates are described, and an example is presented of their use for configuration space representation of a mechanical arm (where Cartesian coordinates cannot be used).

  12. Hawking radiation of Kerr-Newman black hole in different tortoise coordinate transformations

    Science.gov (United States)

    Ibungochouba Singh, T.

    2013-10-01

    Hawking radiation effect of Maxwell’s electromagnetic fields in the Kerr-Newman black hole space-time is investigated using two different tortoise coordinate transformations. It has been shown that the new tortoise coordinate transformation produces constant term ξ in the expression of surface gravity and Hawking temperature. If ξ is set to zero, the surface gravity and Hawking temperature will be equal to those obtained from the old tortoise coordinate transformation. This indicates that new transformation is more reliable and accurate. The black body radiant spectrum of photon displays a new spin-rotation coupling effect.

  13. Coordinate system applied to magnetic suspension project between Shanghai and Hangzhou

    Institute of Scientific and Technical Information of China (English)

    Yimin SHI; Lihua WANG; Yan LUO

    2008-01-01

    In order to satisfy the requirement for route location of a magnetic suspension project between Shanghai and Hangzhou, this paper proposes to adopt a new form of geodetic coordinate system, which is defined by meridians and parallel circles but with two coordinate parameters expressed by length. Not only the coordinate systems for route location along the whole line can be unified, but also the precision of lengths and angles obtained from simple formulas are very high and there are not any map projection distortions. This has been proven by calculation.

  14. Gazing behavior and coordination during piano duo performance.

    Science.gov (United States)

    Kawase, Satoshi

    2014-02-01

    This study was designed to investigate the roles of gazing behavior during piano duo performance by highlighting coordination among performers. Experiment 1 was conducted under four conditions: invisible, only the body visible, only the head visible, and face -to -face. Experiment 2 was conducted under three conditions: invisible, only the movable head visible, and only the fixed head visible. In both experiments, performers looked toward each other just before temporal changes during coordination moments, which improved synchronization accuracy. The results also showed that gazing without movement cues to some extent facilitated synchronization, although asynchrony was greater under the restricted- movement condition than under the free- movement condition. The following results were obtained:(1) Mutual gaze is important for reducing timing lag between performers. (2) Mutual gaze modulates remarkable and arbitrary temporal expressions, such as fermata. (3) Performers may utilize movements as visual cues for strict synchronization. PMID:24170378

  15. The coordination of regional interest in developing river basin

    Institute of Scientific and Technical Information of China (English)

    Chen Xiangman

    2006-01-01

    River basin is a special region with the characteristics of entirety and relation, regionality and diversity,gradation and network, openness and dissipation etc. It is an important unit that organizes and governs national economy as well as a natural region. In river basin, all natural essential factors relate closely each other, and there is remarkable influence between inter-regions. In the process of developing river basin, the multiplex main interest body,the diverse interest demand and the multi-ways of interest realization constitute a complicated interest network, and result in various contradictions and conflicts. Therefore, effective regional interest coordination mechanism should be established to coordinate various regional interest relations. They are the public interest realization mechanism, the fair interest assignment mechanism, the effective interest integration mechanism, the expedited interest expression mechanism and the reasonable interest compensative mechanism.

  16. Designinig Coordination among Human and Software Agents

    OpenAIRE

    Perini, Anna; Susi, Angelo; Giunchiglia, Fausto

    2002-01-01

    The goal of this paper is to propose a new methodology for designing coordination between human angents and software agents and, ultimately, among software agents. The methodology is based on two key ideas. The first is that coordination should be designed in steps, according to a precise software engineering methodology, and starting from the specification of early requirements. The second is that coordination should be modeled as dependency between actors. Two actors may depend on one anoth...

  17. Methods of Safety Improvements at Coordinated Signals

    OpenAIRE

    Li, Wei; Tarko, Andrew P.

    2008-01-01

    In this research, the safety impact of arterial signal coordination is investigated. Based on the findings, procedures are proposed to incorporate safety considerations into signal coordination design. In addition, a software tool is developed to facilitate the use of the research findings. Signal coordination has been extensively employed as a tool to optimize an arterial system’s mobility performance, commonly measured by the total number of vehicle stops and the time of delays. Although ve...

  18. Managing interteam coordination within and between organizations

    OpenAIRE

    de Vries, Thomas Arend

    2015-01-01

    To accomplish complex tasks and effectively respond to environmental contingencies, teams must coordinate task-related issues with other teams (i.e., interteam coordination). Regrettably, interteam coordination is often complicated by misunderstandings that can arise from differences in teams’ languages, routines, and goals. In this dissertation I examine organizational structures, team composition strategies, and individual team member characteristics that can help to overcome such difficult...

  19. Convergence of barycentric coordinates to barycentric kernels

    KAUST Repository

    Kosinka, Jiří

    2016-02-12

    We investigate the close correspondence between barycentric coordinates and barycentric kernels from the point of view of the limit process when finer and finer polygons converge to a smooth convex domain. We show that any barycentric kernel is the limit of a set of barycentric coordinates and prove that the convergence rate is quadratic. Our convergence analysis extends naturally to barycentric interpolants and mappings induced by barycentric coordinates and kernels. We verify our theoretical convergence results numerically on several examples.

  20. Black Hole Structure in Schwarzschild Coordinates

    OpenAIRE

    Proffitt D.

    2014-01-01

    In the analysis of the interior region of both stationary and rotating black holes, it is customary to switch to a set of in-falling coordinates to avoid problems posed by the coordinate singularity at the event horizon. I take the view here that to understand the physics of black holes, we need to restrict ourselves to book keeper or Schwarzschild coordinates of a distant observer if we are to derive measurable properties. I show that one can derive interesting proper...

  1. Using reinforcement learning to coordinate better

    OpenAIRE

    Excelente-Toledo, C.B.; Jennings, N. R.

    2005-01-01

    This paper examines the potential and the impact of introducing learning capabilities into autonomous agents that make decisions at run-time about which mechanism to exploit in order to coordinate their activities. Specifically, our motivating hypothesis is that to deal with dynamic and unpredictable environments it is important to have agents that learn the right situations in which to attempt coordination and the right coordination method to use in those situations. In particular, the effic...

  2. Spectral Asymmetry Due to Magnetic Coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong-kyu; Boozer, Allen H.; Menard, Jonathan E.

    2008-05-06

    The use of magnetic coordinates is ubiquitous in toroidal plasma physics, but the distortion in Fourier spectra produced by these coordinates is not well known. A spatial symmetry of the field is not always represented by a symmetry in the Fourier spectrum when magnetic coordinates are used because of the distortion of the toroidal angle. The practical importance of spectral distortion is illustrated with a tokamak example.

  3. Noncommutative Btz Black Hole in Different Coordinates

    Science.gov (United States)

    Ee, Chang-Young

    We consider noncommutative BTZ black hole solutions in two different coordinate systems, the polar and rectangular coordinates. The analysis is carried out by obtaining noncommutative solutions of U(1, 1) × U(1, 1) Chern-Simons theory on AdS3 in the two coordinate systems via the Seiberg-Witten map. This is based on the noncommutative extension of the equivalence between the classical BTZ solution and the solution of ordinary SU(1, 1) × SU(1, 1) Chern-Simons theory on AdS3. The obtained solutions in these noncommutative coordinate systems become different in the first order of the noncommutativity parameter θ.

  4. Linkage isomerism in coordination polymers.

    Science.gov (United States)

    Benmansour, Samia; Setifi, Fatima; Triki, Smail; Gómez-García, Carlos J

    2012-02-20

    The use of the recently prepared polynitrile ligand tcnopr3OH(-) ([(NC)(2)CC(OCH(2)CH(2)CH(2)OH)C(CN)(2)](-)) with different salts of Fe(II), Co(II), and Ni(II) has led to a very rare example of linkage isomerism in a coordination chain. These pairs of linkage isomers can be formulated as [M(tcnopr3OH-κN,κO)(2)(H(2)O)(2)]; M = Fe (1), Co (3), and Ni(5) and [M(tcnopr3OH-κN,κN')(2)(H(2)O)(2)]; M = Fe (2), Co (4), and Ni (6). Compounds 1-2, 3-4, and 5-6 are three pairs of linkage isomers since they present the same formula and chain structure and they only differ in the connectivity of the polynitrile ligand bridging the metal ions in the chain: through a N and an O atom (1κN:2κO-isomer) or through two N atoms (1κN:2κN'-isomer). The magnetic properties show, as expected, very similar behaviors for both isomers. PMID:22296602

  5. Effect of gravity on three-dimensional coordination number distribution in liquid phase sintered microstructures

    Energy Technology Data Exchange (ETDEWEB)

    Tewari, A.; Gokhale, A.M.; Gereman, R.M.

    1999-10-08

    Gravity affects microstructural evolution when a liquid phase is present during sintering. The effect of gravity on the three-dimensional coordination number distribution of tungsten grains in liquid phase sintered heavy alloy specimens is quantitatively characterized. A combination of montage serial sectioning, digital image processing, and unbiased stereological sampling procedures is used to estimate the coordination number distribution in three-dimensional microstructures. The microgravity environment decreases the mean coordination number. However, hardly any isolated grains are observed in the specimens, liquid phase sintered in a microgravity environment. The effect of microgravity on the coordination numbers mainly resides in its effect on the mean coordination number. In all specimens, there is a strong correlation between grain size and coordination number, which can be expressed as [D{sub c}/{bar D}]{sup 2} = C/C{sub 0} where C{sub 0} is the mean coordination number, {bar D} the global average size of the tungsten grains, and D{sub c} the average size of only those grains which have coordination number C.

  6. New form of geodetic coordinate system taking two length quantity as coordinate parameters

    Institute of Scientific and Technical Information of China (English)

    Yimin SHI; Ziyang ZHU; Yeming FAN

    2009-01-01

    A new form of geodetic coordinate system based on geodesic coordinates instead of geodetic long-itude and latitude was proposed. The vertical and horizontal geodesic coordinates measured with length were defined as coordinate parameters, but the two families of coordinate curves were still meridians and parallel circles. The first fundamental form on the ellipsoidal surface and its three coefficients were deduced by the geodesic coordinate. The formula for the latitudinal scale factor of length for geodetic parallel lines was derived, by which the obtained result conformed to that standard value calculated from geodetic latitude, and it is applicable in the range of 400 km from north to south. Therefore, it lays the foundation for establishing the differential equation and differential relationship based on this type of coordinate parameters; and consequently, it is convenient and accurate enough to operate on the ellipsoidal surface in this new form of geodetic coordinate system.

  7. Guidelines for the Practice of Parenting Coordination

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Parenting coordination is a nonadversarial dispute resolution process that is court ordered or agreed on by divorced and separated parents who have an ongoing pattern of high conflict and/or litigation about their children. These guidelines are designed to address the developing area of practice known as parenting coordination. In response to the…

  8. COORDINATION CHEMISTRY IN THE REPUBLIC OF MOLDOVA

    OpenAIRE

    Ion Bulhac; Aurelian Gulea; Dumitru Batâr

    2009-01-01

    This article is dedicated to the history of apparition and development of Coordination chemistry in Moldova.The main scientific centres are characterized, as well as their main research directions. The most valuable results in fundamental and applicative research are described, obtained in the field of coordination chemistry in the republic.

  9. Distributed Coordination of Household Electricity Consumption

    DEFF Research Database (Denmark)

    Juelsgaard, Morten; Teixeira, Andre; Johansson, Mikael;

    2014-01-01

    This work presents a distributed framework for coordination of flexible electricity consumption for a number of households in the distribution grid. We conduct coordination with the purpose of minimizing a trade-off between individual concerns about discomfort and electricity cost, on the one hand...

  10. Social Ties and Coordination on Negative Reciprocity

    DEFF Research Database (Denmark)

    Reuben, Ernesto; van Winden, Frans

    on the responders’ decisions, beliefs, and emotions. We find that friends punish the proposer more than strangers, and that they are more likely to coordinate their punishment (without communication). Both punishment and coordination are explained by the responders’ emotional reactions. Furthermore, the responders......’ expectations are better predictors of emotions and destruction than their fairness perceptions...

  11. 40 CFR 109.6 - Coordination.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS CRITERIA FOR STATE, LOCAL AND REGIONAL OIL REMOVAL CONTINGENCY PLANS § 109.6 Coordination. For the purposes of coordination... consultation with private interests. A copy of any oil removal contingency plan developed by State and...

  12. Articulatory Constraints on Interpersonal Postural Coordination

    Science.gov (United States)

    Shockley, Kevin; Baker, Aimee A.; Richardson, Michael J.; Fowler, Carol A.

    2007-01-01

    Cooperative conversation has been shown to foster interpersonal postural coordination. The authors investigated whether such coordination is mediated by the influence of articulation on postural sway. In Experiment 1, talkers produced words in synchrony or in alternation, as the authors varied speaking rate and word similarity. Greater shared…

  13. Advanced Coordinating Control System for Power Plant

    Institute of Scientific and Technical Information of China (English)

    WU Peng; WEI Shuangying

    2006-01-01

    The coordinating control system is popular used in power plant. This paper describes the advanced coordinating control by control methods and optimal operation, introduces their principals and features by using the examples of power plant operation. It is wealthy for automation application in optimal power plant operation.

  14. COORDINATION CHEMISTRY IN THE REPUBLIC OF MOLDOVA

    Directory of Open Access Journals (Sweden)

    Ion Bulhac

    2009-06-01

    Full Text Available This article is dedicated to the history of apparition and development of Coordination chemistry in Moldova.The main scientific centres are characterized, as well as their main research directions. The most valuable results in fundamental and applicative research are described, obtained in the field of coordination chemistry in the republic.

  15. You're a "What"? Recycling Coordinator

    Science.gov (United States)

    Torpey, Elka Maria

    2011-01-01

    Recycling coordinators supervise curbside and dropoff recycling programs for municipal governments or private firms. Today, recycling is mandatory in many communities. And advancements in collection and processing methods have helped to increase the quantity of materials for which the recycling coordinator is responsible. In some communities,…

  16. 77 FR 260 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2012-01-04

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of call for nominations. SUMMARY: The Forest Resource Coordinating Committee (FRCC) is filling eight vacant positions. Candidates who wish to be considered for membership on the Forest...

  17. 78 FR 6806 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-01-31

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Forest Resource Committee Meeting will meet in Arlington, Va. The committee is... copying. The public may inspect comments received on the Forest Resource Coordinating Committee Web...

  18. Energy Materials Coordinating Committee (EMaCC)

    Energy Technology Data Exchange (ETDEWEB)

    1991-05-31

    This report summarizes EMaCC activities for fiscal year 1990 and describes the materials research programs of various offices and divisions within the department. The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further the effective use of materials expertise within the department. (JL)

  19. Unpacking Coordination Benefits in Supply Networks

    DEFF Research Database (Denmark)

    Petrick, Irene J.; Maitland, Carleen; Pogrebnyakov, Nicolai

    2016-01-01

    This paper examines how coordination among firms in supply networks generates benefits in the short and long terms for firms. It focuses on information technology (IT) and process improvement coordination. Analysis was performed on quantitative and qualitative data from a sample of SMEs in plasti...

  20. Coordination of Knowledge in Judging Animated Motion

    Science.gov (United States)

    Thaden-Koch, Thomas C.; Dufresne, Robert J.; Mestre, Jose P.

    2006-01-01

    Coordination class theory is used to explain college students' judgments about animated depictions of moving objects. diSessa's coordination class theory models a "concept" as a complex knowledge system that can reliably determine a particular type of information in widely varying situations. In the experiment described here, fifty individually…

  1. Encoding and Retrieval During Bimanual Rhythmic Coordination

    Science.gov (United States)

    Shockley, Kevin; Turvey, Michael T.

    2005-01-01

    In 2 experiments, bimanual 1:1 rhythmic coordination was performed concurrently with encoding or retrieval of word lists. Effects of divided attention (DA) on coordination were indexed by changes in mean relative phase and recurrence measures of shared activity between the 2 limbs. Effects of DA on memory were indexed by deficits in recall…

  2. Kinematics Analysis of a Parallel Coordinate Measuring Machine

    OpenAIRE

    Xiulong Chen; Weiming Feng; Xianyang Sun; Qing Gao

    2013-01-01

    A 4‐UPS‐UPU 5‐Degrees of Freedom PCMM (Parallel coordinate measuring machine), which can achieve three translation degrees of freedom and two rotational degrees of freedom, is presented in this paper. The inverse position model of the 4‐UPS‐UPU PCMM is established. The Jacobian matrix, and the expressions of velocity and acceleration are deduced. Furthermore, a numerical analysis of the inverse solutions of the position, velocity and acceleration are carried out. The results are confirmed by ...

  3. Coordinated School Health and the Contribution of a District Wellness Coordinator

    Science.gov (United States)

    Westrich, Lisa; Sanchez, Monika; Strobel, Karen

    2015-01-01

    Background: A San Francisco Bay Area school health initiative was established in fall 2010 to improve wellness programs in 4 local school districts using the Coordinated School Health (CSH) model. This study examines the role of district-wide wellness coordinators and the ways in which they contribute to intentional coordination of health and…

  4. Scalable Social Coordination using Enmeshed Queries

    CERN Document Server

    Chen, Jianjun; Varghese, George

    2012-01-01

    Social coordination allows users to move beyond awareness of their friends to efficiently coordinating physical activities with others. While specific forms of social coordination can be seen in tools such as Evite, Meetup and Groupon, we introduce a more general model using what we call {\\em enmeshed queries}. An enmeshed query allows users to declaratively specify an intent to coordinate by specifying social attributes such as the desired group size and who/what/when, and the database returns matching queries. Enmeshed queries are continuous, but new queries (and not data) answer older queries; the variable group size also makes enmeshed queries different from entangled queries, publish-subscribe systems, and dating services. We show that even offline group coordination using enmeshed queries is NP-hard. We then introduce efficient heuristics that use selective indices such as location and time to reduce the space of possible matches; we also add refinements such as delayed evaluation and using the relative...

  5. Coordinate metrology accuracy of systems and measurements

    CERN Document Server

    Sładek, Jerzy A

    2016-01-01

    This book focuses on effective methods for assessing the accuracy of both coordinate measuring systems and coordinate measurements. It mainly reports on original research work conducted by Sladek’s team at Cracow University of Technology’s Laboratory of Coordinate Metrology. The book describes the implementation of different methods, including artificial neural networks, the Matrix Method, the Monte Carlo method and the virtual CMM (Coordinate Measuring Machine), and demonstrates how these methods can be effectively used in practice to gauge the accuracy of coordinate measurements. Moreover, the book includes an introduction to the theory of measurement uncertainty and to key techniques for assessing measurement accuracy. All methods and tools are presented in detail, using suitable mathematical formulations and illustrated with numerous examples. The book fills an important gap in the literature, providing readers with an advanced text on a topic that has been rapidly developing in recent years. The book...

  6. Knowledge coordination in distributed software management

    DEFF Research Database (Denmark)

    Persson, John Stouby; Mathiassen, Lars

    2012-01-01

    resources. We have therefore studied virtual meetings among the managers of a cross-organizational and cross-border joint venture who was highly dedicated to multimodal communication. Since coordination is most clearly noticeable when it is lacking, we investigated knowledge coordination by analyzing...... communication breakdowns on recordings of their combined teleconferencing and real-time collaborative modeling. As a result, we offer theoretical propositions that explain how distributed software managers can deal with communication breakdowns and effectively coordinate knowledge through multimodal virtual......Software organizations are increasingly relying on cross-organizational and cross-border collaboration, requiring effective coordination of distributed knowledge. However, such coordination is challenging due to spatial separation, diverging communities-of-practice, and unevenly distributed...

  7. Learning and coordinating in a multilayer network

    CERN Document Server

    Lugo, Haydee

    2014-01-01

    We introduce a two layer network model for social coordination incorporating two relevant ingredients: a) different networks of interaction to learn and to obtain a payoff , and b) decision making processes based both on social and strategic motivations. Two populations of agents are distributed in two layers with intralayer learning processes and playing interlayer a coordination game. We find that the skepticism about the wisdom of crowd and the local connectivity are the driving forces to accomplish full coordination of the two populations, while polarized coordinated layers are only possible for all-to-all interactions. Local interactions also allow for full coordination in the socially efficient Pareto-dominant strategy in spite of being the riskier one.

  8. Sensory Motor Coordination in Robonaut

    Science.gov (United States)

    Peters, Richard Alan, II

    2003-01-01

    As a participant of the year 2000 NASA Summer Faculty Fellowship Program, I worked with the engineers of the Dexterous Robotics Laboratory at NASA Johnson Space Center on the Robonaut project. The Robonaut is an articulated torso with two dexterous arms, left and right five-fingered hands, and a head with cameras mounted on an articulated neck. This advanced space robot, now driven only teleoperatively using VR gloves, sensors and helmets, is to be upgraded to a thinking system that can find, interact with and assist humans autonomously, allowing the Crew to work with Robonaut as a (junior) member of their team. Thus, the work performed this summer was toward the goal of enabling Robonaut to operate autonomously as an intelligent assistant to astronauts. Our underlying hypothesis is that a robot can develop intelligence if it learns a set of basic behaviors (i.e., reflexes - actions tightly coupled to sensing) and through experience learns how to sequence these to solve problems or to accomplish higher-level tasks. We describe our approach to the automatic acquisition of basic behaviors as learning sensory-motor coordination (SMC). Although research in the ontogenesis of animals development from the time of conception) supports the approach of learning SMC as the foundation for intelligent, autonomous behavior, we do not know whether it will prove viable for the development of autonomy in robots. The first step in testing the hypothesis is to determine if SMC can be learned by the robot. To do this, we have taken advantage of Robonaut's teleoperated control system. When a person teleoperates Robonaut, the person's own SMC causes the robot to act purposefully. If the sensory signals that the robot detects during teleoperation are recorded over several repetitions of the same task, it should be possible through signal analysis to identify the sensory-motor couplings that accompany purposeful motion. In this report, reasons for suspecting SMC as the basis for

  9. Conserved role of Drosophila melanogaster FoxP in motor coordination and courtship song.

    Science.gov (United States)

    Lawton, Kristy J; Wassmer, Taryn L; Deitcher, David L

    2014-07-15

    FoxP2 is a highly conserved vertebrate transcription factor known for its importance in human speech and language production. Disruption of FoxP2 in several vertebrate models indicates a conserved functional role for this gene in both sound production and motor coordination. Although FoxP2 is known to be strongly expressed in brain regions important for motor coordination, little is known about FoxP2's role in the nervous system. The recent discovery of the well-conserved Drosophila melanogaster homolog, FoxP, provides an opportunity to study the role of this crucial gene in an invertebrate model. We hypothesized that, like FoxP2, Drosophila FoxP is important for behaviors requiring fine motor coordination. We used targeted RNA interference to reduce expression of FoxP and assayed the effects on a variety of adult behaviors. Male flies with reduced FoxP expression exhibit decreased levels of courtship behavior, altered pulse-song structure, and sex-specific motor impairments in walking and flight. Acute disruption of synaptic activity in FoxP expressing neurons using a temperature-sensitive shibire allele dramatically impaired motor coordination. Utilizing a GFP reporter to visualize FoxP in the fly brain reveals expression in relatively few neurons in distributed clusters within the larval and adult CNS, including distinct labeling of the adult protocerebral bridge - a section of the insect central complex known to be important for motor coordination and thought to be homologous to areas of the vertebrate basal ganglia. Our results establish the necessity of this gene in motor coordination in an invertebrate model and suggest a functional homology with vertebrate FoxP2. PMID:24747661

  10. Biclusters Visualization and Detection Using Parallel Coordinate Plots

    Science.gov (United States)

    Cheng, K. O.; Law, N. F.; Siu, W. C.; Liew, A. W. C.

    2007-11-01

    The parallel coordinate (PC) plot is a powerful visualization tools for high-dimensional data. In this paper, we explore its usage on gene expression data analysis. We found that both the additive-related and the multiplicative-related coherent genes exhibit special patterns in the PC plots. One-dimensional clustering can then be applied to detect these patterns. Besides, a split-and-merge mechanism is employed to find the biggest coherent subsets inside the gene expression matrix. Experimental results showed that our proposed algorithm is effective in detecting various types of biclusters. In addition, the biclustering results can be visualized under a 2D setting, in which objective and subjective cluster quality evaluation can be performed.

  11. Noncommutative BTZ Black Hole in Different Coordinates

    OpenAIRE

    Chang-Young, Ee

    2009-01-01

    We consider noncommutative BTZ black hole solutions in two different coordinate systems, the polar and rectangular coordinates. The analysis is carried out by obtaining noncommutative solutions of $U(1,1)\\times U(1,1)$ Chern-Simons theory on $AdS_3$ in the two coordinate systems via the Seiberg-Witten map. This is based on the noncommutative extension of the equivalence between the classical BTZ solution and the solution of ordinary $SU(1,1)\\times SU(1,1)$ Chern-Simons theory on $AdS_3$. The ...

  12. Anatomic Breast Coordinate System for Mammogram Analysis

    DEFF Research Database (Denmark)

    Karemore, Gopal Raghunath; Brandt, S; Karssemeijer, N;

    2011-01-01

    represented by geodesic distance (s) from nipple and parametric angle (¿) as shown in figure 1. The scoring technique called MTR (mammographic texture resemblance marker) used this breast coordinate system to extract Gaussian derivative features. The features extracted using the (x,y) and the curve...... alignment error. Potentially this coordinate system may be used also for improving precision in CAD systems. Keywords: Breast Coordinate system, Breast Cancer, Imaging marker.......Purpose Many researchers have investigated measures also other than density in the mammogram such as measures based on texture to improve breast cancer risk assessment. However, parenchymal texture characteristics are highly dependent on the orientation of vasculature structure and fibrous tissue...

  13. Black Hole Structure in Schwarzschild Coordinates

    Directory of Open Access Journals (Sweden)

    Proffitt D.

    2014-07-01

    Full Text Available In the analysis of the interior region of both stationary and rotating black holes, it is customary to switch to a set of in-falling coordinates to avoid problems posed by the coordinate singularity at the event horizon. I take the view here that to understand the physics of black holes, we need to restrict ourselves to book keeper or Schwarzschild coordinates of a distant observer if we are to derive measurable properties. I show that one can derive interesting properties of black holes th at might explain some of the observational evidence available without the necessity of introducing further ad hoc conjectures.

  14. Calculation of Hamada coordinates for a large-aspect-ratio tokamak

    International Nuclear Information System (INIS)

    The application of the well-known moment equation approach to neoclassical transport requires the use of Hamada coordinates in three-dimensional toroidal plasmas. The lack of analytical expressions and the difficulty associated with the numerical calculation of these coordinates has strongly limited the use of this approach. In this paper analytical calculations of Hamada coordinates for a large-aspect-ratio tokamak are presented. Knowledge of these coordinates for this relatively simple two-dimensional case will allow, for the first time, a general analytical application of the moment equation approach, and also a check of this approach against well-known results. In particular, it is shown here that the approach correctly reproduces the Pfirsch--Schlueter diffusion rate

  15. Coordination of the maize transcriptome by a conserved circadian clock

    Directory of Open Access Journals (Sweden)

    Harmon Frank G

    2010-06-01

    Full Text Available Abstract Background The plant circadian clock orchestrates 24-hour rhythms in internal physiological processes to coordinate these activities with daily and seasonal changes in the environment. The circadian clock has a profound impact on many aspects of plant growth and development, including biomass accumulation and flowering time. Despite recent advances in understanding the circadian system of the model plant Arabidopsis thaliana, the contribution of the circadian oscillator to important agronomic traits in Zea mays and other cereals remains poorly defined. To address this deficit, this study investigated the transcriptional landscape of the maize circadian system. Results Since transcriptional regulation is a fundamental aspect of circadian systems, genes exhibiting circadian expression were identified in the sequenced maize inbred B73. Of the over 13,000 transcripts examined, approximately 10 percent displayed circadian expression patterns. The majority of cycling genes had peak expression at subjective dawn and dusk, similar to other plant circadian systems. The maize circadian clock organized co-regulation of genes participating in fundamental physiological processes, including photosynthesis, carbohydrate metabolism, cell wall biogenesis, and phytohormone biosynthesis pathways. Conclusions Circadian regulation of the maize genome was widespread and key genes in several major metabolic pathways had circadian expression waveforms. The maize circadian clock coordinated transcription to be coincident with oncoming day or night, which was consistent with the circadian oscillator acting to prepare the plant for these major recurring environmental changes. These findings highlighted the multiple processes in maize plants under circadian regulation and, as a result, provided insight into the important contribution this regulatory system makes to agronomic traits in maize and potentially other C4 plant species.

  16. Interactions of ruthenium coordination cubes with DNA

    OpenAIRE

    Barry, Nicolas P. E.; Abd Karim, Nurul H.; Vilar, Ramón; Therrien, Bruno

    2010-01-01

    The interactions of four octacationic ruthenium coordination cubes with duplex and quadruplex (telomeric and c-myc) DNA have been studied by FID and SPR, showing these cubes to bind strongly to tetrastranded DNA structures.

  17. General relativistic hydrodynamics in curvilinear coordinates

    CERN Document Server

    Montero, Pedro J; Müller, Ewald

    2013-01-01

    In this paper we report on what we believe is the first successful implementation of relativistic hydrodynamics, coupled to dynamical spacetimes, in spherical polar coordinates without symmetry assumptions. We employ a high-resolution shock-capturing scheme, which requires that the equations be cast in flux-conservative form. One example of such a form is the :Valencia" formulation, which has been adopted in numerous applications, in particular in Cartesian coordinates. Here we generalize this formulation to allow for a reference-metric approach, which provides a natural framework for calculations in curvilinear coordinates. In spherical polar coordinates, for example, it allows for an analytical treatment of the singular r and sin(\\theta) terms that appear in the equations. We experiment with different versions of our generalized Valencia formulation in numerical implementations of relativistic hydrodynamics for both fixed and dynamical spacetimes. We consider a number of different tests -- non-rotating and ...

  18. Coordination Polymer Gels by Electron Beam

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ji Ha; Cho, Young Je; Jung, Jong Hwa [Gyeongsang National Univ., Jinju (Korea, Republic of)

    2011-07-01

    Hydrogenation of a pyridine derivative possessing tetrazole moieties as end groups, without long alkyl chain groups, results in the formation of a Mg(NO{sub 3}){sub 2} coordination polymer gel. The polymer exhibits a strong fluorescence enhancement upon gel formation. 1 can also be gloated with a variety of magnesium anions such as SO{sub 4}{sup 2-}, NO{sub 3}{sup -}, Cl{sup -}, Br{sup -} and I{sup -}, indicating that the coordination polymer gel formation of 1 does not strongly depends on anions. The Seam and ABM images of Mg{sup 2+} coordination polymer gel 1 display a flabbier network with several micrometers long, widths in the range 60-70 nm and thicknesses of about 3 nm. In addition, photophysical studies show that the hydrogel exhibits a typical {pi}-{pi} transition and gives rise to high fluorescence behavior. The coordination polymer hydrogel exhibits viscoelastic behavior as evidenced from the rheological studies.

  19. Coordination Polymer Gels by Electron Beam

    International Nuclear Information System (INIS)

    Hydrogenation of a pyridine derivative possessing tetrazole moieties as end groups, without long alkyl chain groups, results in the formation of a Mg(NO3)2 coordination polymer gel. The polymer exhibits a strong fluorescence enhancement upon gel formation. 1 can also be gloated with a variety of magnesium anions such as SO42-, NO3-, Cl-, Br- and I-, indicating that the coordination polymer gel formation of 1 does not strongly depends on anions. The Seam and ABM images of Mg2+ coordination polymer gel 1 display a flabbier network with several micrometers long, widths in the range 60-70 nm and thicknesses of about 3 nm. In addition, photophysical studies show that the hydrogel exhibits a typical π-π transition and gives rise to high fluorescence behavior. The coordination polymer hydrogel exhibits viscoelastic behavior as evidenced from the rheological studies

  20. Modeling, Control and Coordination of Helicopter Systems

    CERN Document Server

    Ren, Beibei; Chen, Chang; Fua, Cheng-Heng; Lee, Tong Heng

    2012-01-01

    Modeling, Control and Coordination of Helicopter Systems provides a comprehensive treatment of helicopter systems, ranging from related nonlinear flight dynamic modeling and stability analysis to advanced control design for single helicopter systems, and also covers issues related to the coordination and formation control of multiple helicopter systems to achieve high performance tasks. Ensuring stability in helicopter flight is a challenging problem for nonlinear control design and development. This book is a valuable reference on modeling, control and coordination of helicopter systems,providing readers with practical solutions for the problems that still plague helicopter system design and implementation. Readers will gain a complete picture of helicopters at the systems level, as well as a better understanding of the technical intricacies involved. This book also: Presents a complete picture of modeling, control and coordination for helicopter systems Provides a modeling platform for a general class of ro...

  1. Relativistic Positioning Systems: The Emission Coordinates

    CERN Document Server

    Coll, B; Coll, Bartolom\\'{e}; Pozo, Jos\\'{e} Mar\\'{I}a

    2006-01-01

    This paper introduces some general properties of the gravitational metric and the natural basis of vectors and covectors in 4-dimensional emission coordinates. Emission coordinates are a class of space-time coordinates defined and generated by 4 emitters (satellites) broadcasting their proper time by means of electromagnetic signals. They are a constitutive ingredient of the simplest conceivable relativistic positioning systems. Their study is aimed to develop a theory of these positioning systems, based on the framework and concepts of general relativity, as opposed to introducing `relativistic effects' in a classical framework. In particular, we characterize the causal character of the coordinate vectors, covectors and 2-planes, which are of an unusual type. We obtain the inequality conditions for the contravariant metric to be Lorentzian, and the non-trivial and unexpected identities satisfied by the angles formed by each pair of natural vectors. We also prove that the metric can be naturally split in such...

  2. Selective Placement Program Coordinator (SPPC) Directory

    Data.gov (United States)

    Office of Personnel Management — List of the Selective Placement Program Coordinators (SPPC) in Federal agencies, updated as needed. Users can filter the list by choosing a state and/or agency name.

  3. Local Physical Coordinates from Symplectic Projector Method

    Science.gov (United States)

    de Andrade, M. A.; Santos, M. A.; Vancea, I. V.

    The basic arguments underlying the symplectic projector method are presented. By this method, local free coordinates on the constraint surface can be obtained for a broader class of constrained systems. Some interesting examples are analyzed.

  4. Duality between coordinates and Dirac field

    CERN Document Server

    Abdalla, Maria Christina B; Vancea, I V

    2000-01-01

    The duality between the Cartesian coordinates on the Minkowski space-time andthe Dirac field is investigated. Two distinct possibilities to define thisduality are shown to exist. In both cases, the equations satisfied byprepotentials are of second order.

  5. Coordination Approaches for Complex Software Systems

    OpenAIRE

    Bosse, T.; Hoogendoorn, M; Treur, J.

    2006-01-01

    This document presents the results of a collaboration between the Vrije Universiteit Amsterdam, Department of Artificial Intelligence and Force Vision to investigate coordination approaches for complex software systems. The project was funded by Force Vision.

  6. HYbrid Coordinate Ocean Model (HYCOM): Global

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Global HYbrid Coordinate Ocean Model (HYCOM) and U.S. Navy Coupled Ocean Data Assimilation (NCODA) 3-day, daily forecast at approximately 9-km (1/12-degree)...

  7. Feature Clustering for Accelerating Parallel Coordinate Descent

    Energy Technology Data Exchange (ETDEWEB)

    Scherrer, Chad; Tewari, Ambuj; Halappanavar, Mahantesh; Haglin, David J.

    2012-12-06

    We demonstrate an approach for accelerating calculation of the regularization path for L1 sparse logistic regression problems. We show the benefit of feature clustering as a preconditioning step for parallel block-greedy coordinate descent algorithms.

  8. Spectral Networks and Fenchel-Nielsen Coordinates

    Science.gov (United States)

    Hollands, Lotte; Neitzke, Andrew

    2016-06-01

    It is known that spectral networks naturally induce certain coordinate systems on moduli spaces of flat SL( K)-connections on surfaces, previously studied by Fock and Goncharov. We give a self-contained account of this story in the case K = 2 and explain how it can be extended to incorporate the complexified Fenchel-Nielsen coordinates. As we review, the key ingredient in the story is a procedure for passing between moduli of flat SL(2)-connections on C (equipped with a little extra structure) and moduli of equivariant GL(1)-connections over a covering {Σ to C}; taking holonomies of the equivariant GL(1)-connections then gives the desired coordinate systems on moduli of SL(2)-connections. There are two special types of spectral network, related to ideal triangulations and pants decompositions of C; these two types of network lead to Fock-Goncharov and complexified Fenchel-Nielsen coordinate systems, respectively.

  9. Calibration of transformation matrix in object body coordinate and camera coordinate

    Science.gov (United States)

    Song, Jincheng; Sun, Zengyu; Guo, Lei; Wang, Dongwei

    2013-01-01

    In this paper, a new coordinate system calibration is proposed in order to define the dependence of position between object body coordinate and camera coordinate which can be used in object measurement by the formation of image. Due to existing the fabrication and installation error, it is difficult to make system parallel between object body coordinate and camera coordinate. To resolve it, the deviation of the two coordinate system is demanded to measure detailed. The deviation compensation in the image processing software can ensure the accuracy the pitch angle and azimuth in the destination image of camera measurement system. In order to definite the position, a base coordinate system of theodolite is set by mutual-space measurement principle. After the measurement of theodolite system, a transformation matrix of the base coordinate system can be deduced. Changing the position of the theodolite station and adjusting the cross-screw to infinity, the transformation matrix between the base coordinate and star-sensor coordinate can be deduced by image formation of the destination at infinity. The position relation between object body and camera can be calculated by the transformation matrix. The results of the measurement experiment show that the gauging repeatability is 6' which can meet the system gauging demands.

  10. Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene

    OpenAIRE

    Kratsios, Paschalis; Stolfi, Alberto; Levine, Michael; Hobert, Oliver

    2011-01-01

    Cholinergic motor neurons are defined by the co-expression of a battery of genes which encode proteins that act sequentially to synthesize, package and degrade acetylcholine and reuptake its breakdown product, choline. How expression of these critical motor neuron identity determinants is controlled and coordinated is not understood. We show here that in the nematode Caenorhabditis elegans all members of the cholinergic gene battery, as well as many other markers of terminal motor neuron fate...

  11. Trust and team coordination in critical situations

    Directory of Open Access Journals (Sweden)

    Adrian H. Pitariu

    2008-01-01

    Full Text Available In this paper I explore the process of team coordination. I propose a model by which team coordination emerges as a function of team mental models and team trust. Furthermore, I introduce a hierarchical approach to team mental models, and propose a framework that provides a better understanding of team processes and opens new avenues of research in the area of team cognition. I conclude with implications for future research and practice.

  12. Distributional consequences of capital tax coordination

    OpenAIRE

    2005-01-01

    This paper has two ambitions. First, we review the economic literature on tax coordination. Second, we argue that the taxation of capital is not an issue of efficiency, but instead an issue of equity. In particular, capital tax coordination can alter the vertical distribution of income between the production factors capital and labour. Capital is in perfectly elastic supply in a small open economy. Therefore the tax incidence falls to the immobile factor, labour. By contrast, capital is in in...

  13. Trust and team coordination in critical situations

    OpenAIRE

    Adrian H. Pitariu

    2008-01-01

    In this paper I explore the process of team coordination. I propose a model by which team coordination emerges as a function of team mental models and team trust. Furthermore, I introduce a hierarchical approach to team mental models, and propose a framework that provides a better understanding of team processes and opens new avenues of research in the area of team cognition. I conclude with implications for future research and practice.

  14. Decentralized Coordination of Autonomous Vehicles at intersections

    OpenAIRE

    Makarem, Laleh; Gillet, Denis

    2011-01-01

    In this paper, the decentralized coordination of point-mass autonomous vehicles at intersections using navigation functions is considered. As main contribution, the inertia of the vehicles is taken into account to enable on-board energy optimization for crossing. In such a way, heavier vehicles that need more energy and time for acceleration or breaking are given an indirect priority at intersections. The proposed decentralized coordination scheme of autonomous vehicles at intersection is com...

  15. Unions’ Bargaining Coordination in Multinational Enterprises

    OpenAIRE

    Buccella, Domenico

    2011-01-01

    This paper investigates the coordination of bargaining activities among labor unions in a Multinational Enterprise (MNE) with plants in different countries. Making use of a threestage game where the parties sequentially decide whether o coordinate negotiations, it derives the bargaining regimes arising as sub-game perfect equilibria. In presence of workers perfect substitutes in production and symmetry in the plants' efficiency, it is shown that unions' transaction costs may attenuate the con...

  16. Product Architecture as a Coordination System (Japanese)

    OpenAIRE

    OKUNO (FUJIWARA) Masahiro; Watanabe, Yasunori

    2006-01-01

    Baldwin and Clark (2000) brought the substantial attention to the concept of product architecture. This concept, particularly the concept of module architecture, defines a product system as a "coordination system," taking the viewpoint that a product system is an object that is used by human users or developed by human developers. In this paper, product architecture is defined as a design concept for a product system that calls for complex part-to-part coordination in order to fulfill the use...

  17. The Lanthanide Contraction beyond Coordination Chemistry.

    Science.gov (United States)

    Ferru, Geoffroy; Reinhart, Benjamin; Bera, Mrinal K; Olvera de la Cruz, Monica; Qiao, Baofu; Ellis, Ross J

    2016-05-10

    The lanthanide contraction is conceptualized traditionally through coordination chemistry. Here we break this mold in a structural study of lanthanide ions dissolved in an amphiphilic liquid. The lanthanide contraction perturbs the weak interactions between molecular aggregates that drive mesoscale assembly and emergent behavior. The weak interactions correlate with lanthanide ion transport properties, suggesting new strategies for rare-earth separation that exploit forces outside of the coordination sphere. PMID:27060294

  18. Behavioral Strategies in Repeated Pure Coordination Games

    OpenAIRE

    Rami Zwick; Amnon Rapoport; Alison King Chung Lo

    2001-01-01

    We study experimentally a class of pure coordination games as a special case of the Consumer Choice of Prizes game developed by Rapoport et al. (2000). We find a high level of group coordination coupled with considerable switching in the choice of locations. Two models are proposed and tested to account for the results, one postulating the formation of conventions, and the other invoking the mixed strategy equilibrium solution for risk-neutral players. We reject both models as possible candid...

  19. On Double Interpolation in Polar Coordinates

    Directory of Open Access Journals (Sweden)

    Antoniu Nicula

    2009-10-01

    Full Text Available Interpolation is an important tool in numerical modeling of real-life systems. The Lagrange interpolation is frequently used, due to particular advantages in implementation. The bi-dimensional version may be implemented with Cartesian or with polar coordinate system. Choice of the coordinate system is important in order to obtain accurate results. The polar case has particular properties that can be exploited to minimize some of the common disadvantages of polynomial interpolation.

  20. On Double Interpolation in Polar Coordinates

    OpenAIRE

    Antoniu Nicula; Florin Vancea; Codruţa Vancea

    2009-01-01

    Interpolation is an important tool in numerical modeling of real-life systems. The Lagrange interpolation is frequently used, due to particular advantages in implementation. The bi-dimensional version may be implemented with Cartesian or with polar coordinate system. Choice of the coordinate system is important in order to obtain accurate results. The polar case has particular properties that can be exploited to minimize some of the common disadvantages of polynomial interpolation.

  1. Coordinate Friendly Structures, Algorithms and Applications

    OpenAIRE

    Peng, Zhimin; Wu, Tianyu; Xu, Yangyang; Ming YAN; Yin, Wotao

    2016-01-01

    This paper focuses on coordinate update methods, which are useful for solving problems involving large or high-dimensional datasets. They decompose a problem into simple subproblems, where each updates one, or a small block of, variables while fixing others. These methods can deal with linear and nonlinear mappings, smooth and nonsmooth functions, as well as convex and nonconvex problems. In addition, they are easy to parallelize. The great performance of coordinate update methods depends on ...

  2. Co-ordinating Product Developing Activities

    DEFF Research Database (Denmark)

    Terkelsen, Søren Bendix

    The paper contains a presentation of research methods to be used in case studies in product development and a presentation on how to deal with Design Co-ordination according to litterature......The paper contains a presentation of research methods to be used in case studies in product development and a presentation on how to deal with Design Co-ordination according to litterature...

  3. Team Reasoning as a Guide to Coordination

    OpenAIRE

    Lahno, Amrei Marie; Lahno, Bernd

    2014-01-01

    A particular problem of traditional Rational Choice Theory is that it cannot explain equilibrium selection in simple coordination games. In this paper we analyze and discuss the solution concept for common coordination problems as incorporated in the theory of Team Reasoning (TR). Special consideration is given to TR’s concept of opportunistic choice and to the resulting restrictions in using private information. We report results from a laboratory experiment in which teams were given a chanc...

  4. 75 FR 39089 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-07-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an..., Shipping Coordinating Committee, Department of State. BILLING CODE 4710-09-P...

  5. 77 FR 16316 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-03-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... . Dated: March 9, 2012. Brian Robinson, Executive Secretary, Shipping Coordinating Committee,...

  6. 75 FR 3272 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-01-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... . ] Dated: January 12, 2009. Jon Trent Warner, Executive Secretary, Shipping Coordinating...

  7. 77 FR 47491 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-08-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... . Dated: August 1, 2012. Brian Robinson, Executive Secretary, Shipping Coordinating Committee,...

  8. 75 FR 54415 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-09-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct four...: August 30, 2010. Jon Trent Warner, Executive Secretary, Shipping Coordinating Committee, Department...

  9. 77 FR 12641 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an..., 2012. Brian Robinson, Executive Secretary, Shipping Coordinating Committee, Department of...

  10. 77 FR 70525 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-11-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an..., 2012. Brian Robinson, Executive Secretary, Shipping Coordinating Committee, Department of...

  11. 76 FR 70529 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2011-11-14

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will...: November 7, 2011. Brian Robinson, Executive Secretary, Shipping Coordinating Committee, Department of...

  12. 75 FR 65551 - Shipping Coordinating Committee; Notice of Subcommittee Meeting

    Science.gov (United States)

    2010-10-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Subcommittee Meeting The Shipping Coordinating Committee (SHC) will conduct.... Jon Trent Warner, Executive Secretary, Shipping Coordinating Committee, Department of State....

  13. 75 FR 10546 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-03-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... . ] Dated: March 2, 2010. Jon Trent Warner, Executive Secretary, Shipping Coordinating Committee,...

  14. 78 FR 45592 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-07-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an..., 2013. Marc Zlomek, Executive Secretary, Shipping Coordinating Committee, Department of State....

  15. 77 FR 70526 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-11-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an...: November 14, 2012. Brian Robinson, Executive Secretary, Shipping Coordinating Committee, Department...

  16. 75 FR 82129 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-12-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct two... Trent Warner, Executive Secretary, Shipping Coordinating Committee, Department of State. BILLING...

  17. 77 FR 28923 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-05-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an..., 2012. Brian Robinson, Executive Secretary, Shipping Coordinating Committee, Department of...

  18. 76 FR 82026 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2011-12-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... . Dated: December 22, 2011. Brian Robinson, Executive Secretary, Shipping Coordinating...

  19. 77 FR 47490 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-08-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct open.... Brian Robinson, Executive Secretary, Shipping Coordinating Committee, Department of State. BILLING...

  20. 77 FR 64576 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-10-22

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will... . Dated: October 15, 2012. Brian Robinson, Executive Secretary, Shipping Coordinating...

  1. Coordinations between gene modules control the operation of plant amino acid metabolic networks

    Directory of Open Access Journals (Sweden)

    Galili Gad

    2009-01-01

    Full Text Available Abstract Background Being sessile organisms, plants should adjust their metabolism to dynamic changes in their environment. Such adjustments need particular coordination in branched metabolic networks in which a given metabolite can be converted into multiple other metabolites via different enzymatic chains. In the present report, we developed a novel "Gene Coordination" bioinformatics approach and use it to elucidate adjustable transcriptional interactions of two branched amino acid metabolic networks in plants in response to environmental stresses, using publicly available microarray results. Results Using our "Gene Coordination" approach, we have identified in Arabidopsis plants two oppositely regulated groups of "highly coordinated" genes within the branched Asp-family network of Arabidopsis plants, which metabolizes the amino acids Lys, Met, Thr, Ile and Gly, as well as a single group of "highly coordinated" genes within the branched aromatic amino acid metabolic network, which metabolizes the amino acids Trp, Phe and Tyr. These genes possess highly coordinated adjustable negative and positive expression responses to various stress cues, which apparently regulate adjustable metabolic shifts between competing branches of these networks. We also provide evidence implying that these highly coordinated genes are central to impose intra- and inter-network interactions between the Asp-family and aromatic amino acid metabolic networks as well as differential system interactions with other growth promoting and stress-associated genome-wide genes. Conclusion Our novel Gene Coordination elucidates that branched amino acid metabolic networks in plants are regulated by specific groups of highly coordinated genes that possess adjustable intra-network, inter-network and genome-wide transcriptional interactions. We also hypothesize that such transcriptional interactions enable regulatory metabolic adjustments needed for adaptation to the stresses.

  2. Analysis of Coordinated Motions of Humanoid Robot Fingers Using Interphalangeal Joint Coordination

    OpenAIRE

    Byoung-Ho Kim

    2014-01-01

    In this study, we analyse the coordinated motions of humanoid robot fingers using an interphalangeal joint coordination. For this purpose, four humanoid robot fingers with different sizes have been considered. A biomimetic interphalangeal joint coordination (IJC) formulation based on the grasp configuration of human fingers has been presented for humanoid robot fingers. The usefulness of the specified IJC formulation for human-like finger motion has been verified through comparative demonstra...

  3. Business coordination across borders within toyota : a case study focusing the coordination between Japan and Toyota

    OpenAIRE

    Jumreorn, Nathida; Promprasit, Supadet

    2009-01-01

    Date: May 28th, 2009Level: Master Thesis: EFO705 (15 Credits)Authors: Nathida Jumreorn (NJN08002)Supadet Promprasit (SPT08001)Title: Managing Multinational Corporation: Coordination Mechanisms within theMNCsTutor: Leif LinnskogResearch Problem:How does Toyota coordinate its business across borders? A case study with particularfocuses on the relationship between Japan and Thailand.Purpose: To describe how Toyota manage its business across borders in perspective ofrelationship and coordination ...

  4. Analysis of Coordinated Motions of Humanoid Robot Fingers Using Interphalangeal Joint Coordination

    Directory of Open Access Journals (Sweden)

    Byoung-Ho Kim

    2014-04-01

    Full Text Available In this study, we analyse the coordinated motions of humanoid robot fingers using an interphalangeal joint coordination. For this purpose, four humanoid robot fingers with different sizes have been considered. A biomimetic interphalangeal joint coordination (IJC formulation based on the grasp configuration of human fingers has been presented for humanoid robot fingers. The usefulness of the specified IJC formulation for human-like finger motion has been verified through comparative demonstrations. As a result, a proper coordination of humanoid robot fingertips can be achieved by applying our IJC formulation. Also the IJC formulation can be used to design of humanoid robot fingers.

  5. Vascular Gene Expression: A Hypothesis

    Directory of Open Access Journals (Sweden)

    Angélica Concepción eMartínez-Navarro

    2013-07-01

    Full Text Available The phloem is the conduit through which photoassimilates are distributed from autotrophic to heterotrophic tissues and is involved in the distribution of signaling molecules that coordinate plant growth and responses to the environment. Phloem function depends on the coordinate expression of a large array of genes. We have previously identified conserved motifs in upstream regions of the Arabidopsis genes, encoding the homologs of pumpkin phloem sap mRNAs, displaying expression in vascular tissues. This tissue-specific expression in Arabidopsis is predicted by the overrepresentation of GA/CT-rich motifs in gene promoters. In this work we have searched for common motifs in upstream regions of the homologous genes from plants considered to possess a primitive vascular tissue (a lycophyte, as well as from others that lack a true vascular tissue (a bryophyte, and finally from chlorophytes. Both lycophyte and bryophyte display motifs similar to those found in Arabidopsis with a significantly low E-value, while the chlorophytes showed either a different conserved motif or no conserved motif at all. These results suggest that these same genes are expressed coordinately in non- vascular plants; this coordinate expression may have been one of the prerequisites for the development of conducting tissues in plants. We have also analyzed the phylogeny of conserved proteins that may be involved in phloem function and development. The presence of CmPP16, APL, FT and YDA in chlorophytes suggests the recruitment of ancient regulatory networks for the development of the vascular tissue during evolution while OPS is a novel protein specific to vascular plants.

  6. An Expression for the Temperature Gradient in Chaotic Fields

    Energy Technology Data Exchange (ETDEWEB)

    S.R. Hudson

    2008-12-22

    A coordinate system adapted to the invariant structures of chaotic magnetic fields is constructed. The coordinates are based on a set of ghost-surfaces, defined via an action-gradient flow between the minimax and minimizing periodic orbits. The construction of the chaotic coordinates allows an expression describing the temperature gradient across a chaotic magnetic field to be derived. The results are in close agreement with a numerical calculation.

  7. Low cation coordination in oxide melts

    Energy Technology Data Exchange (ETDEWEB)

    Skinner, Lawrie [State University of New York, Stony Brook; Benmore, Chris J [Argonne National Laboratory (ANL); Du, Jincheng [University of North Texas; Weber, Richard [Argonne National Laboratory (ANL); Neuefeind, Joerg C [ORNL; Tumber, Sonia [Materials Development, Inc., Evanston, IL; Parise, John B [Stony Brook University (SUNY)

    2014-01-01

    The complete set of Faber-Ziman partial pair distribution functions for a rare earth oxide liquid were measured for the first time by combining aerodynamic levitation, neutron diffraction, high energy x-ray diffraction and isomorphic substitution using Y2 O3 and Ho2 O3 melts. The average Y- O coordination is measured to be 5.5(2), which is significantly less than the octahedral coordination of crystalline Y2 O3 (or Ho2 O3 ). Investigation of high temperature La2 O3 , ZrO2 , SiO2 , and Al2 O3 melts by x-ray diffraction and molecular dynamics simulations also show lower-than-crystal cation- oxygen coordination. These measurements suggest a general trend towards lower M-O coordination compared to their crystalline counterparts. It is found that this coordination number drop is larger for lower field strength, larger radius cations and is negligible for high field strength (network forming) cations. These findings have broad implications for predicting the local structure and related physical properties of metal-oxide melts and oxide glasses.

  8. TRAINING STRATEGIES SPECIFIC TO THE PHYSICAL EDUCATION USED IN ORDER TO DEVELOP THE COORDINATIVE CAPACITIES - EQUILIBRIUM

    Directory of Open Access Journals (Sweden)

    FINICHIU Marin

    2010-04-01

    Full Text Available Coordinative capacities express themselves in the gesticulation sphere and help the motor learning being connected to the organization, control and movement adjustment processes; a good coordination represents the condition necessary to an execution as much as possible close to the established motor program.The equilibrium capacity is defined as being the maintaining capacity of the body in a certain established position and its re-equilibration after high amplitude shifting and solicitations; in maintaining the equilibrium the vestibular analyser’s role is determined.Methods: Proper investigation methods have been used among which - the observation method, the measurements and recording methods (The Bass test, the Flamingo test, the Matorin test, the experimentalmethod and the obtained data processing and interpretation methods – the statistic-mathematical method and the graphic one.Results: The use in a higher percentage the means specific to the coordinative capacities – equilibrium, had as effect a significant increase, from one measurement to another, by applying the three tests, both for the female students pattern and for the male students, fact emphasized also by presenting the three graphics.Conclusions: The use, in a higher percentage, the means specific to the development of the coordinative capacities – equilibrium, also the variety of working conditions during the physical education class, has contributed to the improvement of the calculated arithmetic means for the coordination tests – equilibrium. Onthis ground we can make a methodical line, in the analytical program, for the development of the students’ coordinative capacities.

  9. Optimal coordinated voltage control of power systems

    Institute of Scientific and Technical Information of China (English)

    LI Yan-jun; HILL David J.; WU Tie-jun

    2006-01-01

    An immune algorithm solution is proposed in this paper to deal with the problem of optimal coordination of local physically based controllers in order to preserve or retain mid and long term voltage stability. This problem is in fact a global coordination control problem which involves not only sequencing and timing different control devices but also tuning the parameters of controllers. A multi-stage coordinated control scheme is presented, aiming at retaining good voltage levels with minimal control efforts and costs after severe disturbances in power systems. A self-pattern-recognized vaccination procedure is developed to transfer effective heuristic information into the new generation of solution candidates to speed up the convergence of the search procedure to global optima. An example of four bus power system case study is investigated to show the effectiveness and efficiency of the proposed algorithm, compared with several existing approaches such as differential dynamic programming and tree-search.

  10. Coordinated Voltage Control of Active Distribution Network

    Directory of Open Access Journals (Sweden)

    Xie Jiang

    2016-01-01

    Full Text Available This paper presents a centralized coordinated voltage control method for active distribution network to solve off-limit problem of voltage after incorporation of distributed generation (DG. The proposed method consists of two parts, it coordinated primal-dual interior point method-based voltage regulation schemes of DG reactive powers and capacitors with centralized on-load tap changer (OLTC controlling method which utilizes system’s maximum and minimum voltages, to improve the qualified rate of voltage and reduce the operation numbers of OLTC. The proposed coordination has considered the cost of capacitors. The method is tested using a radial edited IEEE-33 nodes distribution network which is modelled using MATLAB.

  11. TIARA: Toward accelerator R&D coordination

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    The preparatory phase of the TIARA (Test Infrastructure and Accelerator Research Area) project has begun. In January, members from 11 research institutes in 8 European countries began a three-year collaboration intended to enhance, improve and structure R&D efforts in the area of accelerator science and technology in Europe.   Partly funded by the European Commission under its Seventh Framework Programme (FP7), the TIARA project is being coordinated by the CEA (Commissariat à l’Énergie Atomique et aux Energies Alternatives). “The aim of the project is to arrive at an organisational structure that will provide coordination for R&D efforts and associated infrastructures in the field of particle accelerators in Europe,” explains the CEA’s Céline Tanguy, project coordinator assistant. “The new structure, which we hope will be a durable one, will be set up at the end of the project’s preparatory phase....

  12. On the existence of MSA coordinates

    CERN Document Server

    Hernández-Pastora, J L

    2009-01-01

    The static solutions of the axially symmetric vacuum Einstein equations with a finite number of Relativistic Multipole Moments are described by means of a function that can be written in the same analytic form as the Newtonian gravitational multipole potential. A family of so-called MSA (Multipole-Symmetry Adapted) coordinates are introduced and calculated at any multipole order to perform the transformation of the Weyl solutions. In analogy with a previous result obtained in Newtonian gravity, the existence of a symmetry of a certain system of differential equations leading to the determination of that kind of multipole solutions in General Relativity is explored. The relationship between the existence of this kind of coordinate and the symmetries mentioned is proved for some cases, and the characterization of the MSA system of coordinates by means of this relationship is discussed.

  13. Nonparametric variational optimization of reaction coordinates

    Science.gov (United States)

    Banushkina, Polina V.; Krivov, Sergei V.

    2015-11-01

    State of the art realistic simulations of complex atomic processes commonly produce trajectories of large size, making the development of automated analysis tools very important. A popular approach aimed at extracting dynamical information consists of projecting these trajectories into optimally selected reaction coordinates or collective variables. For equilibrium dynamics between any two boundary states, the committor function also known as the folding probability in protein folding studies is often considered as the optimal coordinate. To determine it, one selects a functional form with many parameters and trains it on the trajectories using various criteria. A major problem with such an approach is that a poor initial choice of the functional form may lead to sub-optimal results. Here, we describe an approach which allows one to optimize the reaction coordinate without selecting its functional form and thus avoiding this source of error.

  14. Coordinating knowledge transfer within manufacturing networks

    DEFF Research Database (Denmark)

    Yang, Cheng; Johansen, John; Boer, Harry

    Along with increasing globalization, the management of international manufacturing networks is becoming increasingly important for industrial companies. This paper mainly focuses on the coordination of knowledge transfer within manufacturing networks. In this context, we propose the time-place ma......Along with increasing globalization, the management of international manufacturing networks is becoming increasingly important for industrial companies. This paper mainly focuses on the coordination of knowledge transfer within manufacturing networks. In this context, we propose the time......-place matrix as a tool for mapping the distribution of knowledge within manufacturing networks. Using this tool, four important questions about the coordination of knowledge transfer within a manufacturing network are identified: know-where, know-what, know-when, know-how to transfer. The relationships among...

  15. Nonparametric variational optimization of reaction coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Banushkina, Polina V.; Krivov, Sergei V., E-mail: s.krivov@leeds.ac.uk [Astbury Center for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT (United Kingdom)

    2015-11-14

    State of the art realistic simulations of complex atomic processes commonly produce trajectories of large size, making the development of automated analysis tools very important. A popular approach aimed at extracting dynamical information consists of projecting these trajectories into optimally selected reaction coordinates or collective variables. For equilibrium dynamics between any two boundary states, the committor function also known as the folding probability in protein folding studies is often considered as the optimal coordinate. To determine it, one selects a functional form with many parameters and trains it on the trajectories using various criteria. A major problem with such an approach is that a poor initial choice of the functional form may lead to sub-optimal results. Here, we describe an approach which allows one to optimize the reaction coordinate without selecting its functional form and thus avoiding this source of error.

  16. Non-commutativity in polar coordinates

    CERN Document Server

    Edwards, James P

    2016-01-01

    We reconsider the fundamental commutation relations for non-commutative $\\mathbb{R}^{2}$ described in polar coordinates with non-commutativity parameter $\\theta$. Previous analysis found that the natural transition from Cartesian coordinates to polars led to a representation of $\\left[\\hat{r}, \\hat{\\varphi}\\right]$ as an everywhere diverging series. We compute the Borel resummation of this series, showing that it can subsequently be extended throughout parameter space and hence provide an interpretation of this commutator. Our analysis provides a complete solution for arbitrary $r$ and $\\theta$ that reproduces the earlier calculations at lowest order. We compare our results to previous literature in the (pseudo-)commuting limit, finding a surprising spatial dependence for the coordinate commutator when $\\theta \\gg r^{2}$. We raise some questions for future study in light of this progress.

  17. Coordination: Neural, Behavioral and Social Dynamics

    CERN Document Server

    Fuchs, Armin

    2008-01-01

    One of the most striking features of Coordination Dynamics is its interdisciplinary character. The problems we are trying to solve in this field range from behavioral phenomena of interlimb coordination and coordination between stimuli and movements (perception-action tasks) through neural activation patterns that can be observed during these tasks to clinical applications and social behavior. It is not surprising that close collaboration among scientists from different fields as psychology, kinesiology, neurology and even physics are imperative to deal with the enormous difficulties we are facing when we try to understand a system as complex as the human brain. The chapters in this volume are not simply write-ups of the lectures given by the experts at the meeting but are written in a way that they give sufficient introductory information to be comprehensible and useful for all interested scientists and students.

  18. Two different anionic manganese(II) coordination polymers constructed through dicyanamide coordination bridges.

    Science.gov (United States)

    Wang, Hui Ting

    2015-10-01

    In order to explore new metal coordination polymers and to search for new types of ferroelectrics among hybrid coordination polymers, two manganese dicyanamide complexes, poly[tetramethylammonium [di-μ3-dicyanamido-κ(6)N(1):N(3):N(5)-tri-μ2-dicyanamido-κ(6)N(1):N(5)-dimanganese(II)

  19. Politics of coordination in environmental health

    DEFF Research Database (Denmark)

    Holm, Jesper; Kjærgård, Bente; Jelsøe, Erling

    2015-01-01

    Environment and health are deeply rooted into each other, which we are reminded of now and then when major hazards like the Fukushima nuclear accident occur, or when scientific discovery reveals that certain persistent health problems as declining sperm counts of men, are embedded in environmental...... environmental policy integration, for studying the efforts and paradoxes in sector co-ordination, in order to reflect on the pro et cons of integrative approaches to environment and public health. We will give an overview of the various approaches to coordinative efforts from an international to a national...

  20. Penta-coordinate phosphorous compounds and biochemistry

    Institute of Scientific and Technical Information of China (English)

    林长学; 韩波; 赵玉芬; 万荣; 李艳梅; 冯亚兵; 成昌梅

    2002-01-01

    The relationship between penta-coordinate phosphorus compounds and biochemistry is briefly reviewed. Some interesting phenomena such as peptide formation, ester formation, ester exchange on phosphorus and N to O migration occur at room temperature when the amino group of amino acid is associated with phosphoryl group. Serine or threonine in conjugate of nucleo-side-amino acid could recognize different nucleobases. N-phosphoryl Histine and Ser-His dipep-tide could cleavage nucleic acid, protein and ester in neutral medium. It is found that the above phenomena all undergo penta-coordinate intermediate of phosphorus atom, which is proposed as the key factor to determine their activities.

  1. IAEA Co-ordinated Research Program (CRP)

    International Nuclear Information System (INIS)

    The Coordinated Research Project is a topical collection of research agreements and contracts. The research contracts are awarded with financial support of about 10-20% of the total contract cost. Among the activities of the project is the organization of consultant group meetings and workshops involving several international experts and representatives of users and developers of border radiation monitoring equipment. The project also supports in coordinating the development of equipment and techniques for up-to-date border monitoring and in establishing of a process for providing nuclear forensics support to member states

  2. Noncommutative BTZ Black Hole in Polar Coordinates

    OpenAIRE

    Chang-Young, Ee; Lee, Daeho; Lee, Youngone

    2008-01-01

    Based on the equivalence between the three dimensional gravity and the Chern-Simons theory, we obtain a noncommutative BTZ black hole solution as a solution of $U(1,1)\\times U(1,1)$ noncommutative Chern-Simons theory using the Seiberg-Witten map. The Seiberg-Witten map is carried out in a noncommutative polar coordinates whose commutation relation is equivalent to the usual canonical commutation relation in the rectangular coordinates up to first order in the noncommutativity parameter $\\thet...

  3. Modeling Coordination Problems in a Music Ensemble

    DEFF Research Database (Denmark)

    Frimodt-Møller, Søren R.

    2008-01-01

    This paper considers in general terms, how musicians are able to coordinate through rational choices in a situation of (temporary) doubt in an ensemble performance. A fictitious example involving a 5-bar development in an unknown piece of music is analyzed in terms of epistemic logic, more...... specifically a multi-agent system, where it is shown that perfect coordination can only be certain to take place if the musicians have common knowledge of certain rules of the composition. We subsequently argue, however, that the musicians need not agree on the central features of the piece of music in order...

  4. Scorpionates the coordination chemistry of polypyrazolylborate ligands

    CERN Document Server

    Trofimenko, Swiatoslaw

    1999-01-01

    This book deals with polypyrazolylborates (scorpionates), a class of ligands known since 1966, but becoming rapidly popular with inorganic, organometallic and coordination chemists since 1986, because of their versatility and user-friendliness. They can be readily modified sterically and electronically through appropriate substitution on the pyrazole ring and on boron, and have led to a number of firsts in coordination chemistry (first stable CuCO complex, first monomeric MgR complex, and many other such firsts). Their denticity can range from two to four, their "Bite" can be adjusted, and add

  5. Varied control of coordination capabilities of students

    Directory of Open Access Journals (Sweden)

    Sergienko V.N.

    2010-06-01

    Full Text Available The results of testing of coordinating capabilities of students are resulted to differentiation of spatiotemporal parameters. In research took part students in age of 17-20 years. The normative estimations of coordinating capabilities of students are developed. An initial health of students level was determined for 12 ball sigmoid scale. More high exactness and reliability of state information is marked health of students. It reduces a risk level for a health during the decision of practical tasks on physical education.

  6. New tortoise coordinate transformation and Hawking's radiation in de Sitter space

    Science.gov (United States)

    Ibohal, N.; Ibungochouba, T.

    2013-01-01

    Hawking's radiation effect of Klein-Gordon equation, Dirac particles and Maxwell's electromagnetic fields in the non-stationary rotating de Sitter cosmological space-time is investigated by using a new method of generalized tortoise coordinate transformation. It is found that the new transformation produces constant additional terms in the expressions of the surface gravities and the Hawking's temperatures. If the constant terms are set to zero, then the surface gravities and Hawking's temperatures will be equal to those obtained from the old generalized tortoise coordinate transformations. This shows that the new transformations are more reasonable. The Fermionic spectrum of Dirac particles displays a new spin-rotation coupling effect.

  7. Coordinate independence of physical observables in the classical tests of general relativity

    International Nuclear Information System (INIS)

    The coordinate-dependence or independence of various quantities in the physical processes of the classical tests of general relativity is investigated by solving the differential equations for the orbits in the post-post-Newtonian approximation. It is shown that the predictions of the physical observables, such as the perihelion advance, the deflection of light ray and the time delay of radar signals are independent of the choice of the coordinate systems. This is clarified by expressing the observables in terms of the constant of motion, namely, the energy of the system, the angular momentum and the impact parameter

  8. Flat coordinates for Saito Frobenius manifolds and String theory

    CERN Document Server

    Belavin, Alexander; Kononov, Yakov

    2015-01-01

    It was shown in \\cite{DVV} for $2d$ topological Conformal field theory (TCFT) \\cite{EY,W} and more recently in \\cite{BSZ}-\\cite{BB2} for the non-critical String theory \\cite{P}-\\cite{BAlZ} that a number of models of these two types can be exactly solved using their connection with the Frobenius manifold (FM) structure introduced by Dubrovin\\cite{Dub}. More precisely these models are connected with a special case of FMs, so called Saito Frobenius manifolds (SFM)\\cite{Saito} (originally called Flat structure together with the Flat coordinate system), which arise on the space of the versal deformations of the isolated Singularities after choosing of a suitabe so-called Primitive form, and which also arises on the quotient spaces by reflection groups. In this paper we explore the connection of the models of TCFT and non-critical String theory with SFM. The crucial point for obtaining an explicit expression for the correlators is finding the flat coordinates of SFMs as functions of the parameters of the deformed s...

  9. Inter-Organizational Coordination, IT Support, and Environment

    Institute of Scientific and Technical Information of China (English)

    QU Gang; JI Shaobo; MIN Qingfei

    2008-01-01

    Manufacturing organizations must know how to deal with uncertainty, manage environmental impact, effectively coordinate with suppliers, and use information technology (IT) to support coordination. Applying cybernetics and information processing theories, this study explores the relationship between organizational environment, inter-organizational coordination, IT support, and the effectiveness of inter-organizational coordination. Using the case study method, data was collected from six manufacturing firms in China. The results show that inter-organizational system adoption is affected by organizational environment and is related to the management of inter-organizational coordination. Coordination and IT application affect the performance of inter-organizational coordination.

  10. Kinematics Analysis of a Parallel Coordinate Measuring Machine

    Directory of Open Access Journals (Sweden)

    Xiulong Chen

    2013-04-01

    Full Text Available A 4‐UPS‐UPU 5‐Degrees of Freedom PCMM (Parallel coordinate measuring machine, which can achieve three translation degrees of freedom and two rotational degrees of freedom, is presented in this paper. The inverse position model of the 4‐UPS‐UPU PCMM is established. The Jacobian matrix, and the expressions of velocity and acceleration are deduced. Furthermore, a numerical analysis of the inverse solutions of the position, velocity and acceleration are carried out. The results are confirmed by a virtual simulation of the 4‐UPS‐UPU PCMM prototype. This research has laid a solid foundation for the motion control and movement performance analysis of the 4‐UPS‐UPU PCMM.

  11. Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.

    Science.gov (United States)

    Kim, Hyun-Eui; Grant, Ana Rodrigues; Simic, Milos S; Kohnz, Rebecca A; Nomura, Daniel K; Durieux, Jenni; Riera, Celine E; Sanchez, Melissa; Kapernick, Erik; Wolff, Suzanne; Dillin, Andrew

    2016-09-01

    Defects in mitochondrial metabolism have been increasingly linked with age-onset protein-misfolding diseases such as Alzheimer's, Parkinson's, and Huntington's. In response to protein-folding stress, compartment-specific unfolded protein responses (UPRs) within the ER, mitochondria, and cytosol work in parallel to ensure cellular protein homeostasis. While perturbation of individual compartments can make other compartments more susceptible to protein stress, the cellular conditions that trigger cross-communication between the individual UPRs remain poorly understood. We have uncovered a conserved, robust mechanism linking mitochondrial protein homeostasis and the cytosolic folding environment through changes in lipid homeostasis. Metabolic restructuring caused by mitochondrial stress or small-molecule activators trigger changes in gene expression coordinated uniquely by both the mitochondrial and cytosolic UPRs, protecting the cell from disease-associated proteins. Our data suggest an intricate and unique system of communication between UPRs in response to metabolic changes that could unveil new targets for diseases of protein misfolding. PMID:27610574

  12. 7 CFR 624.5 - Coordination.

    Science.gov (United States)

    2010-01-01

    ... Federal Emergency Management Agency (FEMA) or its designee. FEMA is the lead federal agency for... AGRICULTURE WATER RESOURCES EMERGENCY WATERSHED PROTECTION § 624.5 Coordination. (a) If the President declares... with the appropriate State office of emergency preparedness and other Federal, tribal, or...

  13. Coordination of knowledge in judging animated motion

    Science.gov (United States)

    Thaden-Koch, Thomas C.; Dufresne, Robert J.; Mestre, Jose P.

    2006-12-01

    Coordination class theory is used to explain college students’ judgments about animated depictions of moving objects. diSessa’s coordination class theory models a “concept” as a complex knowledge system that can reliably determine a particular type of information in widely varying situations. In the experiment described here, fifty individually interviewed college students judged the realism of two sets of computer animations depicting balls rolling on a pair of tracks. The judgments of students from an introductory physics class were strongly affected by the number of balls depicted (one or two), but the judgments of students from an educational psychology class were not. Coordination analysis of interview transcripts supports the interpretation that physics students’ developing physics knowledge led them to consistently miss or ignore some observations that the other students consistently paid attention to. The analysis highlights the context sensitivity and potential fragility of coordination systems, and leads to the conclusion that students’ developing knowledge systems might not necessarily result in consistently improving performance.

  14. Can we Rationally Learn to Coordinate?

    NARCIS (Netherlands)

    S. Goyal (Sanjeev); M.C.W. Janssen (Maarten)

    1996-01-01

    textabstractIn this paper we examine the issue whether individual rationality considerations are sufficient to guarantee that individuals will learn to coordinate. This question is central in any discussion of whether social phenomena (read: conventions) can be explained in terms of a purely individ

  15. Lunar International Science Coordination/Calibration Targets

    Science.gov (United States)

    Head, J. W.; Issacson, P.; Petro, N.; Runyon, C.; Ohtake, M.; Foing, B.; Grande, M.

    2007-01-01

    A new era of international lunar exploration has begun and will expand over the next four years with data acquired from at least four sophisticated remote sensing missions: KAGUYA (SELENE) [Japan], Chang'E [China], Chandrayaan-l [India], and LRO [United States]. It is recognized that this combined activity at the Moon with modern sophisticated sensors wi II provide unprecedented new information about the Moon and will dramatically improve our understanding of Earth's nearest neighbor. It is anticipated that the blooming of scientific exploration of the Moon by nations involved in space activities will seed and foster peaceful international coordination and cooperation that will benefit all. Summarized here are eight Lunar International Science Coordination/Calibration Targets (L-ISCT) that are intended to a) allow cross-calibration of diverse multi-national instruments and b) provide a focus for training young scientists about a range of lunar science issues. The targets, discussed at several scientific forums, were selected for coordinated science and instrument calibration of orbital data. All instrument teams are encouraged to participate in a coordinated activity of early-release data that will improve calibration and validation of data across independent and diverse instruments.

  16. Issues Surrounding Children with Developmental Coordination Disorder

    Science.gov (United States)

    Sugden, David; Kirby, Amanda; Dunford, Carolyn

    2008-01-01

    Like other developmental disorders such as Attention Deficit Hyperactivity Disorder, specific language impairment and dyslexia, there is no shortage of debate surrounding the condition of Developmental Coordination Disorder. The present article takes a global view of many of these debatable issues, starting with definition and terminology, moving…

  17. Deriving force field parameters for coordination complexes

    DEFF Research Database (Denmark)

    Norrby, Per-Ola; Brandt, Peter

    2001-01-01

    The process of deriving molecular mechanics force fields for coordination complexes is outlined. Force field basics are introduced with an emphasis on special requirements for metal complexes. The review is then focused on how to set up the initial model, define the target, refine the parameters......, and validate the final force field, Alternatives to force field derivation are discussed briefly....

  18. Cost Allocation as a Coordination Mechanism

    NARCIS (Netherlands)

    Diaw, K.

    2003-01-01

    This paper shows that cost allocation can endogenously arise as a coordination mechanism in a decentralized firm.This result is derived in a setting with multiple (internally supplied) resources shared by multiple users, which constitutes a departure from previous literature.While standard cost allo

  19. Adsorption Kinetics in Nanoscale Porous Coordination Polymers

    Energy Technology Data Exchange (ETDEWEB)

    Nune, Satish K.; Thallapally, Praveen K.; McGrail, Benard Peter; Annapureddy, Harsha V. R.; Dang, Liem X.; Mei, Donghai; Karri, Naveen; Alvine, Kyle J.; Olszta, Matthew J.; Arey, Bruce W.; Dohnalkova, Alice

    2015-10-07

    Nanoscale porous coordination polymers were synthesized using simple wet chemical method. The effect of various polymer surfactants on colloidal stability and shape selectivity was investigated. Our results suggest that the nanoparticles exhibited significantly improved adsorption kinetics compared to bulk crystals due to decreased diffusion path lengths and preferred crystal plane interaction.

  20. Coordinate Metrology by Traceable Computed Tomography

    DEFF Research Database (Denmark)

    Müller, Pavel

    X-ray computed tomography (CT) is a measuring technique which has become an important technology in the production environment over the last years. Due to a number of advantages of CT compared to, e.g., coordinate measuring machines (CMMs), CT has been recently spread in the field of manufacturin...

  1. From atomic clocks to coordinate times

    Science.gov (United States)

    Petit, G.

    2006-08-01

    The IAU'1991 Resolution A4, complemented by IAU'2000 Resolution B1.3-4, provide rigorous definitions for barycentric and geocentric reference systems in a relativistic framework and define the coordinate times of these systems as TCB and TCG, respectively. Other coordinate times in use are TT, defined from TCG through IAU'2000 Resolution B1.9, and TDB, whose rigorous definition from TCB is now proposed. For practical use, these coordinate times must be realized and the proper time provided by atomic clocks (Atomic time AT) is used to generate all coordinate times. The present sequence is AT => TT ||> TCG -> TCB ||> TDB, where the sign => indicates the complex series of operations involved in generating International atomic time TAI and where ||> is an exact transformation. The paper examines the uncertainty of realization of TAI and the uncertainty brought by the transformation TCG -> TCB. On-going and future evolutions of atomic clocks are reviewed along with their impact on the diagram of time transformations.

  2. Impact of Colored Light on Cardiorespiratory Coordination

    Directory of Open Access Journals (Sweden)

    Friedrich Edelhäuser

    2013-01-01

    Full Text Available Background. Light exposure to the eye can influence different physiological functions, for example, the suprachiasmatic nucleus (SCN. By affecting the autonomic nervous system, the SCN may influence the heart rate variability (HRV. Standardized colored light exposure alters HRV but the results are inconsistent. In this study we investigated the effects of nonstandardized red light (approx. 640 nm and blue (approx. 480 nm light (approx. 50 lx on cardiorespiratory coordination and HRV. Methods. 17 healthy subjects (7 males, age: 26.5 ± 6.2 years were exposed to the following sequence (10 minutes each: daylight-red light-daylight-blue light-daylight. Red and blue lights were created by daylight passing through colored glass panes. Spectral measures of HRV (LF: low frequency, HF: high frequency oscillations, and sympathovagal balance LF/HF and measures of cardiorespiratory coordination (HRR: heart respiration ratio, PCR: phase coordination ratio were analyzed. Results. The LF component increased and the HF component decreased after red light. Consequently, LF/HF increased after red light. Furthermore, during red light HRR and PCR confined to 4 : 1, that is, 4 heartbeats during one respiratory cycle. Conclusion. Nonstandardized red and blue lights are able to alter the autonomic control reflected by HRV as well as cardiorespiratory coordination.

  3. Metallosupramolecular coordination polyelectrolytes investigated by Moessbauer spectroscopy

    International Nuclear Information System (INIS)

    Metallosupramolecular coordination polyelectrolytes (MEPEs) based on rigid and flexible ditopic bis-terpyridine ligands and Fe(II) ions are investigated by Moessbauer spectroscopy. We demonstrate the influence of mechanical stress induced by grinding on the structure of MEPE as well as the ability of MEPE to self-repair through recrystallisation.

  4. Coordinating investigations of suspected notifiable diseases.

    Science.gov (United States)

    2016-02-27

    The APHA's Veterinary Exotic Notifiable Diseases Unit (VENDU) is a team of vets and scientists that coordinates the investigation of suspected exotic notifiable disease in Great Britain. This article describes the work of the unit and provides a breakdown of the reports investigated in 2015. PMID:26917837

  5. Field transformations, collective coordinates and BRST invariance

    International Nuclear Information System (INIS)

    A very large class of general field transformations can be viewed as a field theory generalization of the method of collective coordinates. The introduction of new variables induces a gauge invariance in the transformed theory, and the freedom left in gauge fixing this new invariance can be used to find equivalent formulations of the same theory. First the Batalin-Fradkin-Vilkovisky formalism is applied to the Hamiltonian formulation of physical systems that can be described in terms of collective coordinates. We then show how this type of collective coordinate scheme can be generalized to field transformations, and discuss the War Identities of the associated BRST invariance. For Yang-Mills theory a connection to topological field theory and the background field method is explained in detail. In general the resulting BRST invariance we find hidden in any quantum field theory can be viewed as a consequence of our freedom in choosing a basis of coordinates φ(χ) in the action S[φ]. (orig.)

  6. Coordinated Collaboration between Heterogeneous Distributed Energy Resources

    Directory of Open Access Journals (Sweden)

    Shahin Abdollahy

    2014-01-01

    Full Text Available A power distribution feeder, where a heterogeneous set of distributed energy resources is deployed, is examined by simulation. The energy resources include PV, battery storage, natural gas GenSet, fuel cells, and active thermal storage for commercial buildings. The resource scenario considered is one that may exist in a not too distant future. Two cases of interaction between different resources are examined. One interaction involves a GenSet used to partially offset the duty cycle of a smoothing battery connected to a large PV system. The other example involves the coordination of twenty thermal storage devices, each associated with a commercial building. Storage devices are intended to provide maximum benefit to the building, but it is shown that this can have a deleterious effect on the overall system, unless the action of the individual storage devices is coordinated. A network based approach is also introduced to calculate some type of effectiveness metric to all available resources which take part in coordinated operation. The main finding is that it is possible to achieve synergy between DERs on a system; however this required a unified strategy to coordinate the action of all devices in a decentralized way.

  7. Coordination under the Shadow of Career Concerns

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht

    2010-01-01

    A firm's innovation process requires employees to develop novel ideas and to coordinate with each other to turn the tacit knowledge embodying these ideas into better products and services. Such work outcomes provide signals about employees' abilities to the labor market, and therefore career conc...

  8. Coordination under the Shadow of Career Concerns

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht

    To innovate, firms require their employees to develop novel ideas and to coordinate with each other to turn these ideas into products, services or business strategies. Because the quality of implemented designs that employees are associated with affects their labor market opportunities, career co...

  9. Coordinated School Health Programs. Position Statement. Revised

    Science.gov (United States)

    National Association of School Nurses (NJ1), 2008

    2008-01-01

    It is the position of the National Association of School Nurses (NASN) that all children should have the right to coordinated school health programs. NASN supports continued research to document the outcomes of these programs. School nurses should use their professional education and skills to assist their schools and communities in the…

  10. Electrician's Helper. Coordinator's Guide. Individualized Study Guide.

    Science.gov (United States)

    Stotts, Danny

    This guide is designed to assist teacher-coordinators supervising cooperative education programs for electrician's helpers in helping students complete a set of individualized, competency-based training activities dealing with electricity and electrical circuits and equipment. The first part of the manual includes a progress chart, a study guide…

  11. Towards reduction of Paradigm coordination models

    NARCIS (Netherlands)

    Andova, S.; Groenewegen, L.P.J.; Vink, E.P. de; Aceto, L.; Mousavi, M.R.

    2011-01-01

    The coordination modelling language Paradigm addresses collaboration between components in terms of dynamic constraints. Within a Paradigm model, component dynamics are consistently specified at a detailed and a global level of abstraction. To enable automated verification of Paradigm models, a tran

  12. 76 FR 79151 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2011-12-21

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Forest Resource Committee Meeting will meet in Washington, DC on January 20, 2012... closed to the public. The Forest Resource Committee is authorized under the Food, Conservation,...

  13. On hydrostatic flows in isentropic coordinates

    NARCIS (Netherlands)

    Bokhove, Onno

    2000-01-01

    The hydrostatic primitive equations of motion which have been used in large-scale weather prediction and climate modelling over the last few decades are analysed with variational methods in an isentropic Eulerian framework. The use of material isentropic coordinates for the Eulerian hydrostatic equa

  14. Duality between coordinates and Dirac field

    OpenAIRE

    Abdalla, M. C. B.; Gadelha, A. L.; Vancea, I. V.

    2000-01-01

    The duality between the Cartesian coordinates on the Minkowski space-time and the Dirac field is investigated. Two distinct possibilities to define this duality are shown to exist. In both cases, the equations satisfied by prepotentials are of second order.

  15. Duality between coordinates and Dirac field

    Science.gov (United States)

    Abdalla, M. C. B.; Gadelha, A. L.; Vancea, I. V.

    2000-07-01

    The duality between the Cartesian coordinates on the Minkowski space-time and the Dirac field is investigated. Two distinct possibilities to define this duality are shown to exist. In both cases, the equations satisfied by prepotentials are of second order.

  16. Three-Dimensional Orthogonal Co-ordinates

    Science.gov (United States)

    Astin, J.

    1974-01-01

    A systematic approach to general orthogonal co-ordinates, suitable for use near the end of a beginning vector analysis course, is presented. It introduces students to tensor quantities and shows how equations and quantities needed in classical problems can be determined. (Author/LS)

  17. Physical Development: Building Strength and Coordination

    Science.gov (United States)

    Strickland, Eric

    2004-01-01

    Strength and coordination are two areas of physical development that seem almost to "take care of themselves"--which may be the reason why they are often overlooked when curriculum planning is under way in many early childhood settings. After all, children are going to get stronger as they grow older, thus, they will also become more coordinated…

  18. Taxation in the MERCOSUR and Coordination Possibilities

    OpenAIRE

    Alberto Daniel Barreix; Luiz Arruda Villela

    2003-01-01

    This paper analyzes the evolution and structure of taxation in the Mercosur countries. Specifically, it covers taxes on goods and services, including general excise taxes and excises taxes, and income taxes, both corporate and personal. It also discusses the role of the tax administration and the appellate process, and concludes with suggestions for tax policy coordination among Mercosur countries.

  19. Attentional Demands on Motor-Respiratory Coordination

    Science.gov (United States)

    Hessler, Eric E.; Amazeen, Polemnia G.

    2009-01-01

    Athletic performance requires the pacing of breathing with exercise, known as motor-respiratory coordination (MRC). In this study, we added cognitive and physical constraints while participants intentionally controlled their breathing locations during rhythmic arm movement. This is the first study to examine a cognitive constraint on MRC.…

  20. Coordination of knowledge in judging animated motion

    Directory of Open Access Journals (Sweden)

    Jose P. Mestre

    2006-11-01

    Full Text Available Coordination class theory is used to explain college students’ judgments about animated depictions of moving objects. diSessa’s coordination class theory models a “concept” as a complex knowledge system that can reliably determine a particular type of information in widely varying situations. In the experiment described here, fifty individually interviewed college students judged the realism of two sets of computer animations depicting balls rolling on a pair of tracks. The judgments of students from an introductory physics class were strongly affected by the number of balls depicted (one or two, but the judgments of students from an educational psychology class were not. Coordination analysis of interview transcripts supports the interpretation that physics students’ developing physics knowledge led them to consistently miss or ignore some observations that the other students consistently paid attention to. The analysis highlights the context sensitivity and potential fragility of coordination systems, and leads to the conclusion that students’ developing knowledge systems might not necessarily result in consistently improving performance.

  1. Supply chain coordination in industrial symbiosis

    DEFF Research Database (Denmark)

    Herczeg, Gabor; Akkerman, Renzo; Hauschild, Michael Zwicky

    2013-01-01

    Industrial symbiosis (IS) is a form of supply chain cooperation in industrial networks in order to achieve collective benefits by leveraging each other’s by-products and sharing services and utilities. This paper investigates the concept of IS from the perspective of supply chain coordination (SCC...

  2. 78 FR 73819 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-12-09

    ... Coordinator, Cooperative Forestry Staff, 202-205-1376 or Karl Dalla Rosa, Cooperative Forestry Staff, 202-205... submit to the Secretary regarding alignment of landowner assistance delivery systems, forest inventory...: November 29, 2013. Paul Ries, Associate Deputy Chief, State and Private Forestry. BILLING CODE 3410-11-P...

  3. INFCE technical co-ordinating committee documents

    International Nuclear Information System (INIS)

    A collection of the documents covering the period December 1977 through February 1980 submitted to or generated by the Technical Co-ordinating Comittee is presented. The documents cover primarily the organizational aspects of INFCE, but conclusions from the various Working Trays are summarized

  4. The Mortensen rule and efficient coordination unemployment

    DEFF Research Database (Denmark)

    Julien, Benoit; Kennes, John; King, Ian

    2006-01-01

    We apply the efficiency axioms of [Mortensen, D. (1982). Efficiency of mating, racing and related games. American Economic Review, 72 968–979.] to a set of matching games involving coordination frictions between buyers. These games include markets with finite numbers of buyers and sellers and...

  5. Derived strengths of preference relations on coordinates

    OpenAIRE

    Wakker, Peter

    1988-01-01

    textabstractway is indicated to derive, from a preference relation on a Cartesian product, strength of preference relations on the coordinate sets. These strengths of preference relations are then used to reformulate several well-known properties of preference relations, and make their meaning more transparent. A new result for dynamic contexts is given.

  6. Coordinating Council. Ninth Meeting: Total Quality Management

    Science.gov (United States)

    1992-01-01

    This report summarizes the 9th meeting of the STI Coordinating Council. The council listened to the speakers' understanding of Total Quality Management (TQM) principles and heard stories of successful applications of these principles. Definitions of quality stated were focused on customer satisfaction. Reports presented by the speakers are also included.

  7. Tensor formulation of the model equations on strong conservation form for an incompressible flow in general coordinates

    DEFF Research Database (Denmark)

    Jørgensen, Bo Hoffmann

    2003-01-01

    This brief report expresses the basic equations of an incompressible flow model in a form which can be translated easily into the form used by a numerical solver. The application of tensor notation makes is possible to effectively address the issue ofnumerical robustness and stating the model...... equations on a general form which accommodate curvilinear coordinates. Strong conservation form is obtained by formulating the equations so that the flow variables, velocity and pressure, are expressed in thephysical coordinate system while the location of evaluation is expressed within the transformed...... coordinate system. The tensor formulation allows both a finite difference and a pseudo-spectral description of the model equations. The intention is for thefinite difference formulation to achieve the same robustness and conservation properties as a finite volume discretization. Furthermore, an invariant...

  8. Distributed sensor coordination for advanced energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Tumer, Kagan [Oregon State Univ., Corvallis, OR (United States). School of Mechanical, Industrial and Manufacturing Engineering

    2015-03-12

    Motivation: The ability to collect key system level information is critical to the safe, efficient and reliable operation of advanced power systems. Recent advances in sensor technology have enabled some level of decision making directly at the sensor level. However, coordinating large numbers of sensors, particularly heterogeneous sensors, to achieve system level objectives such as predicting plant efficiency, reducing downtime or predicting outages requires sophisticated coordination algorithms. Indeed, a critical issue in such systems is how to ensure the interaction of a large number of heterogenous system components do not interfere with one another and lead to undesirable behavior. Objectives and Contributions: The long-term objective of this work is to provide sensor deployment, coordination and networking algorithms for large numbers of sensors to ensure the safe, reliable, and robust operation of advanced energy systems. Our two specific objectives are to: 1. Derive sensor performance metrics for heterogeneous sensor networks. 2. Demonstrate effectiveness, scalability and reconfigurability of heterogeneous sensor network in advanced power systems. The key technical contribution of this work is to push the coordination step to the design of the objective functions of the sensors, allowing networks of heterogeneous sensors to be controlled. By ensuring that the control and coordination is not specific to particular sensor hardware, this approach enables the design and operation of large heterogeneous sensor networks. In addition to the coordination coordination mechanism, this approach allows the system to be reconfigured in response to changing needs (e.g., sudden external events requiring new responses) or changing sensor network characteristics (e.g., sudden changes to plant condition). Impact: The impact of this work extends to a large class of problems relevant to the National Energy Technology Laboratory including sensor placement, heterogeneous sensor

  9. Coordination of soccer players during preseason training.

    Science.gov (United States)

    Tessitore, Antonio; Perroni, Fabrizio; Cortis, Cristina; Meeusen, Romain; Lupo, Corrado; Capranica, Laura

    2011-11-01

    This study aimed to verify whether coordination improves as a result of a preseason soccer training. During 5 experimental sessions (days 1, 6, 11, 15, and 19), 16 semiprofessional male soccer players (22.0 ± 3.6 years) were administered 3 specific soccer tests (speed dribbling, shooting a dead ball, and shooting from a pass) and an interlimb coordination test (total duration of a trial: 60 seconds), consisting of isodirectional and nonisodirectional synchronized (1:1 ratio) hand and foot flexions and extensions at an increasing velocity of execution (80, 120, and 180 b·min(-1)). Furthermore, subjective ratings were monitored to assess the recovery state (RestQ) of the players, their perceived exertion (rating of perceived exertion [RPE]) for the whole body, and the perceived muscle pain (rating of muscle pain [RMP]) for the lower limbs and the internal training load by means of the session-RPE method. The ratios between post and pretraining RPE and RMP increased only during the first 2 experimental sessions and decreased after the second week of the training camp (p = 0.001). The Rest-Q showed increases (p < 0.05) for general stress, conflict/pressure, social recovery, and being in shape dimensions. Conversely, decreases (p < 0.05) were observed for social stress, fatigue, physical complaints dimensions. Throughout the preseason, the players improved their speed dribbling (p = 0.03), Shooting from a Pass (p = 0.02), and interlimb coordination (p < 0.0001) performances. These coordination tests succeeded in discriminating coordination in soccer players and could integrate field test batteries during the whole soccer season, because they were easily and inexpensively administrable by coaches. PMID:21993023

  10. The coordination dynamics of social neuromarkers.

    Science.gov (United States)

    Tognoli, Emmanuelle; Kelso, J A Scott

    2015-01-01

    Social behavior is a complex integrative function that entails many aspects of the brain's sensory, cognitive, emotional and movement capacities. Its neural processes are seldom simultaneous but occur according to precise spatiotemporal choreographies, manifested by the coordination of their oscillations within and between brains. Methods with good temporal resolution can help to identify so-called "neuromarkers" of social function and aid in disentangling the dynamical architecture of social brains. In our ongoing research, we have used dual-electroencephalography (EEG) to study neuromarker dynamics during synchronic interactions in which pairs of subjects coordinate behavior spontaneously and intentionally (social coordination) and during diachronic transactions that require subjects to perceive or behave in turn (action observation, delayed imitation). In this paper, after outlining our dynamical approach to the neurophysiological basis of social behavior, we examine commonalities and differences in the neuromarkers that are recruited for both kinds of tasks. We find the neuromarker landscape to be task-specific: synchronic paradigms of social coordination reveal medial mu, alpha and the phi complex as contributing neuromarkers. Diachronic tasks recruit alpha as well, in addition to lateral mu rhythms and the newly discovered nu and kappa rhythms whose functional significance is still unclear. Social coordination, observation, and delayed imitation share commonality of context: in each of our experiments, subjects exchanged information through visual perception and moved in similar ways. Nonetheless, there was little overlap between their neuromarkers, a result that hints strongly of task-specific neural mechanisms for social behavior. The only neuromarker that transcended both synchronic and diachronic social behaviors was the ubiquitous alpha rhythm, which appears to be a key signature of visually-mediated social behaviors. The present paper is both an entry

  11. The coordination dynamics of social neuromarkers

    Directory of Open Access Journals (Sweden)

    Emmanuelle Tognoli

    2015-10-01

    Full Text Available Social behavior is a complex integrative function that entails many aspects of the brain's sensory, cognitive, emotional and motor capacities. Its neural processes are seldom simultaneous but occur according to precise spatiotemporal choreographies, manifested by the coordination of their oscillations within and between brains. Methods with good temporal resolution can help to identify so-called "neuromarkers" of social function and aid in disentangling the dynamical architecture of social brains. In our ongoing research, we have used dual-EEG to study neuromarker dynamics during synchronic interactions in which pairs of subjects coordinate behavior spontaneously and intentionally (social coordination and during diachronic transactions that require subjects to perceive or behave in turn (action observation, delayed imitation. In this paper, after outlining our dynamical approach to the neurophysiological basis of social behavior, we examine commonalities and differences in the neuromarkers that are recruited for both kinds of tasks. We find the neuromarker landscape to be task-specific: synchronic paradigms of social coordination reveal medial mu, alpha and the phi complex as contributing neuromarkers. Diachronic tasks recruit alpha as well, in addition to lateral mu rhythms and the newly discovered nu and kappa rhythms whose functional significance is still unclear. Social coordination, observation, and delayed imitation share commonality of context: in each of our experiments, subjects exchanged information through visual perception and moved in similar ways. Nonetheless, there was little overlap between their neuromarkers, a result that hints strongly of task-specific neural mechanisms for social behavior. The only neuromarker that transcended both synchronic and diachronic social behaviors was the ubiquitous alpha rhythm, which appears to be a key signature of visually-mediated social behaviors. The present paper is both an entry point and a

  12. Identification of a cis-regulatory element by transient analysis of co-ordinately regulated genes

    Directory of Open Access Journals (Sweden)

    Allan Andrew C

    2008-07-01

    Full Text Available Abstract Background Transcription factors (TFs co-ordinately regulate target genes that are dispersed throughout the genome. This co-ordinate regulation is achieved, in part, through the interaction of transcription factors with conserved cis-regulatory motifs that are in close proximity to the target genes. While much is known about the families of transcription factors that regulate gene expression in plants, there are few well characterised cis-regulatory motifs. In Arabidopsis, over-expression of the MYB transcription factor PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT 1 leads to transgenic plants with elevated anthocyanin levels due to the co-ordinated up-regulation of genes in the anthocyanin biosynthetic pathway. In addition to the anthocyanin biosynthetic genes, there are a number of un-associated genes that also change in expression level. This may be a direct or indirect consequence of the over-expression of PAP1. Results Oligo array analysis of PAP1 over-expression Arabidopsis plants identified genes co-ordinately up-regulated in response to the elevated expression of this transcription factor. Transient assays on the promoter regions of 33 of these up-regulated genes identified eight promoter fragments that were transactivated by PAP1. Bioinformatic analysis on these promoters revealed a common cis-regulatory motif that we showed is required for PAP1 dependent transactivation. Conclusion Co-ordinated gene regulation by individual transcription factors is a complex collection of both direct and indirect effects. Transient transactivation assays provide a rapid method to identify direct target genes from indirect target genes. Bioinformatic analysis of the promoters of these direct target genes is able to locate motifs that are common to this sub-set of promoters, which is impossible to identify with the larger set of direct and indirect target genes. While this type of analysis does not prove a direct interaction between protein and DNA

  13. Uncertainty Calculation of Roundness Assessment by Automatic Differentiation in Coordinate Metrology

    Institute of Scientific and Technical Information of China (English)

    Jia-chun LIN; Michael Krystek; Zhao-yao SHI

    2010-01-01

    Recently, Coordinate Measuring Machines (CMMs) are widely used to measure roundness errors. Roundness is calculated from a large number of points collected from the profiles of the parts. According to the Guide to the Expression of Uncertainty in Measurement (GUM), all measurement results must have a stated uncertainty associated the them. However, no CMMs give the uncertainty value of the roundness, because no suitable measurement uncertainty calculation procedure exists. In the case of roundness measurement in coordinate metrology, this paper suggests the algorithms for the calculation of the measurement uncertainty of the roundness deviation based on the two mainly used association criteria, LSC and MZC. The calculation of the sensitivity coefficients for the uncertainty calculation can be done by automatic differentiation, in order to avoid introducing additional errors by the traditional difference quotient approximations. The proposed methods are exact and need input data only as the measured coordinates of the data points and their associated uncertainties.

  14. A Customizable Model for Chronic Disease Coordination: Lessons Learned From the Coordinated Chronic Disease Program

    Science.gov (United States)

    Sequeira, Sonia; Chavez, Amy Holmes

    2016-01-01

    In 2012, the Centers for Disease Control and Prevention provided funding and technical assistance to all states and territories to implement the Coordinated Chronic Disease Program, marking the first time that all state health departments had federal resources to coordinate chronic disease prevention and control programs. This article describes lessons learned from this initiative and identifies key elements of a coordinated approach. We analyzed 80 programmatic documents from 21 states and conducted semistructured interviews with 7 chronic disease directors. Six overarching themes emerged: 1) focused agenda, 2) identification of functions, 3) comprehensive planning, 4) collaborative leadership and expertise, 5) managed resources, and 6) relationship building. These elements supported 4 essential activities: 1) evidence-based interventions, 2) strategic use of staff, 3) consistent communication, and 4) strong program infrastructure. On the basis of these elements and activities, we propose a conceptual model that frames overarching concepts, skills, and strategies needed to coordinate state chronic disease prevention and control programs. PMID:27032986

  15. A Customizable Model for Chronic Disease Coordination: Lessons Learned From the Coordinated Chronic Disease Program.

    Science.gov (United States)

    Voetsch, Karen; Sequeira, Sonia; Chavez, Amy Holmes

    2016-01-01

    In 2012, the Centers for Disease Control and Prevention provided funding and technical assistance to all states and territories to implement the Coordinated Chronic Disease Program, marking the first time that all state health departments had federal resources to coordinate chronic disease prevention and control programs. This article describes lessons learned from this initiative and identifies key elements of a coordinated approach. We analyzed 80 programmatic documents from 21 states and conducted semistructured interviews with 7 chronic disease directors. Six overarching themes emerged: 1) focused agenda, 2) identification of functions, 3) comprehensive planning, 4) collaborative leadership and expertise, 5) managed resources, and 6) relationship building. These elements supported 4 essential activities: 1) evidence-based interventions, 2) strategic use of staff, 3) consistent communication, and 4) strong program infrastructure. On the basis of these elements and activities, we propose a conceptual model that frames overarching concepts, skills, and strategies needed to coordinate state chronic disease prevention and control programs. PMID:27032986

  16. Visualization of multidimensional data with collocated paired coordinates and general line coordinates

    Science.gov (United States)

    Kovalerchuk, Boris

    2013-12-01

    Often multidimensional data are visualized by splitting n-D data to a set of low dimensional data. While it is useful it destroys integrity of n-D data, and leads to a shallow understanding complex n-D data. To mitigate this challenge a difficult perceptual task of assembling low-dimensional visualized pieces to the whole n-D vectors must be solved. Another way is a lossy dimension reduction by mapping n-D vectors to 2-D vectors (e.g., Principal Component Analysis). Such 2-D vectors carry only a part of information from n-D vectors, without a way to restore n-D vectors exactly from it. An alternative way for deeper understanding of n-D data is visual representations in 2-D that fully preserve n-D data. Methods of Parallel and Radial coordinates are such methods. Developing new methods that preserve dimensions is a long standing and challenging task that we address by proposing Paired Coordinates that is a new type of n-D data visual representation and by generalizing Parallel and Radial coordinates as a General Line coordinates. The important novelty of the concept of the Paired Coordinates is that it uses a single 2-D plot to represent n-D data as an oriented graph based on the idea of collocation of pairs of attributes. The advantage of the General Line Coordinates and Paired Coordinates is in providing a common framework that includes Parallel and Radial coordinates and generating a large number of new visual representations of multidimensional data without lossy dimension reduction.

  17. On relation between Hamada and Boozer magnetic coordinate systems

    International Nuclear Information System (INIS)

    The relation between the Hamada and the Boozer magnetic coordinate systems is clarified by deriving them from a general magnetic field coordinate system. The coordinate transformation from the Hamada to the Boozer coordinate system is performed using a transformation function, which is easily calculated with the knowledge of the magnetic field strength only. In non-axisymmetric systems, the Fourier spectrum of the magnetic field strength only. In non-axisymmetric systems, the Fourier spectrum of the magnetic field strength |B| in the Hamada coordinate system is broader than that in the Boozer coordinate system and the leading modes of |B| in the Hamada coordinate system significantly deviate from a simple model field in comparison with the Boozer coordinate system. The Boozer coordinate system is suitable for numerical calculations, especially, for neoclassical and orbit calculations in non-axisymmetric systems. (author)

  18. A Note on Natural Coordinates and Frenet Frames

    Institute of Scientific and Technical Information of China (English)

    ZHOU Xiaozhou; ZHU Keqin

    2007-01-01

    This paper discusses the relationship between natural coordinates in fluid mechanics and orthogonal curvilinear coordinates. Since orthogonal curvilinear coordinates have some excellent mathematical properties, natural coordinates can be applied more widely if they can be transformed to orthogonal curvilinear coordinates. Frenet formulas which describe the differential properties of natural coordinates were compared with the derivative formulas of orthogonal curvilinear coordinates to show that natural coordinates are not generally orthogonal curvilinear coordinates. A method was introduced to transform natural coordinates into orthogonal curvilinear coordinates by rotating the normal planes of the natural coordinates about the streamlines. The transformation is true as long as the natural coordinates satisfy several equations. Vorticity decomposition in the natural coordinates is used to show that these conditional equations are satisfied only if the streamlines are perpendicular to the vortexlines on every given point in the flow field. These equations apply in both planar flows and axisymmetric flows without a circumferential velocity component, but do not apply in some 3-D flows such as Beltrami flow.

  19. Coordinate Singularities in Harmonically-sliced Cosmologies

    CERN Document Server

    Hern, S D

    2000-01-01

    Harmonic slicing has in recent years become a standard way of prescribing the lapse function in numerical simulations of general relativity. However, as was first noticed by Alcubierre (1997), numerical solutions generated using this slicing condition can show pathological behaviour. In this paper, analytic and numerical methods are used to examine harmonic slicings of Kasner and Gowdy cosmological spacetimes. It is shown that in general the slicings are prevented from covering the whole of the spacetimes by the appearance of coordinate singularities. As well as limiting the maximum running times of numerical simulations, the coordinate singularities can lead to features being produced in numerically evolved solutions which must be distinguished from genuine physical effects.

  20. Non covalent assembly of coordination superstructures

    CERN Document Server

    Khlobystov, A N

    2002-01-01

    The main topic of this work is the design of discrete and polymeric multi-component coordination structures using non-covalent interactions between organic and inorganic molecular components. All of the structures described herein are based on transition metal cations and N-donor heterocyclic bis-exodentate ligands with different geometries and various spacer functionalities. The predominant method used for the structural characterisation of the complexes was single crystal X-ray crystallography. X-ray powder diffraction, IR and NMR spectroscopies and TEM and AFM imaging were used to characterise the bulk products from the reactions. Chapter 1 is a comparative review of non-covalent interactions relevant to coordination superstructures and covers the latest developments in the area of crystal engineering and supramolecular chemistry. The nature, geometry and relative energy of the non-covalent interactions are considered in detail in order to reveal their influence on the structure and properties of complexes...

  1. Muscle coordination changes during intermittent cycling sprints.

    Science.gov (United States)

    Billaut, François; Basset, Fabien A; Falgairette, Guy

    2005-06-01

    Maximal muscle power is reported to decrease during explosive cyclical exercises owing to metabolic disturbances, muscle damage, and adjustments in the efferent neural command. The aim of the present study was to analyze the influence of inter-muscle coordination in fatigue occurrence during 10 intermittent 6-s cycling sprints, with 30-s recovery through electromyographic activity (EMG). Results showed a decrease in peak power output with sprint repetitions (sprint 1 versus sprint 10: -11%, Pversus sprint 10: -90.2 ms, Pcycling sprints of short duration, decreased possibly due to the inability of muscles to maintain maximal force. This reduction in maximal power output occurred in parallel to changes in the muscle coordination pattern after fatigue. PMID:15862899

  2. Coordinating quality practices in Direct Trade coffee

    DEFF Research Database (Denmark)

    Holland, Emil; Kjeldsen, Chris; Kerndrup, Søren

    2016-01-01

    Over the past few decades, many food niches have emerged with a specific focus on quality. In specialty coffee, micro roasters have brought about Direct Trade coffee as a way of organising an alternative around new tastes and qualities through ongoing and ‘direct’ relations to farmers...... and cooperatives. But Direct Trade also involves exporters. We ask, how do exporters and roasters work together in these new coffee relations, and what do they work on? We observe and participate in a situation where Colombian coffee exporters visit Danish roasters. They tour the roasting facilities and taste...... a number of coffees. Often, the term power is used to analyse such value chain interactions, but we argue that the term coordination better opens up these interactions for exploration and analysis. What emerges is a coordination of quality. Through touring and tasting, issues emerge and differences...

  3. Particle simulation in curvilinear coordinate systems

    International Nuclear Information System (INIS)

    We present methods for particle simulation of plasmas in a nearly arbitrary coordinate metric and describe a toroidal electrostatic simulation code that evolved from this effort. A Mercier-type coordinate system is used, with a nonuniform radial grid for improved cross-field resolution. A fast iterative method for solving the Poisson equation is employed, and the interpolation/filtering technique shown to be momentum and energy conserving in the continuum limit. Lorentz ion and drift electron species are used. The code has been thoroughly tested for its reproduction of linear and nonlinear physics, and has been applied to the toroidal drift wave problem and its impact on anomalous transport in tokamaks. 40 refs., 10 figs., 1 tab

  4. Responsive lanthanide coordination polymer for hydrogen sulfide.

    Science.gov (United States)

    Liu, Baoxia; Chen, Yang

    2013-11-19

    Metal organic coordination polymers have received great attention because of their flexible compositions and architecture. Here, we report the design and synthesis of a responsive lanthanide coordination polymer (LCP) for hydrogen sulfide (H2S), utilizing self-assembling of biomolecule nucleotide with luminescent terbium ion (Tb(3+)) and sensitizing silver ion (Ag(+)) in aqueous solution. LCP is highly fluorescent due to the inclusion of Ag(+) ions, which sensitized the fluorescence of Tb(3+) ions. H2S can strongly quench the fluorescence of LCP through its high affinity for Ag(+) ions. Such configurated LCP material from initial building blocks showed high sensitivity and selectivity for H2S and was applied to the determination of H2S in human serum. LCP with Tb(3+) ions also has a long fluorescence lifetime, which allows for time-resolved fluorescence assays, possessing particular advantages to probing H2S in biological systems with autofluorescence. PMID:24191713

  5. The coordination of care across borders

    DEFF Research Database (Denmark)

    Kierkegaard, Patrick

    -savings, improved quality of care, avoidance of unnecessary tests, improved work efficiency, reduced waiting times and improvement in the overall efficiency of the healthcare system. Although benefits exists, healthcare organizations have experienced difficulties attaining them and overall adoption of e...... with implementing a new system, and uncertainty that the technology may actually reduce overall costs. The coordination of care across boundaries presents a plethora of issues that need to be tackled from a policy, legal, practical research perspective. This thesis attempts to address pressing issues...... with a particular focus on the implications health information exchange for the purposes of coordinating care will have on both the patient and healthcare professionals on three levels: international, national and institutional level. The findings of this thesis imply that in order for cross-border health...

  6. Update of technical coordinating committee activities

    Energy Technology Data Exchange (ETDEWEB)

    Alvarado, R.A.

    1995-12-31

    The Technical Coordinating Committee has its origins in the earliest days of implementing the Low-Level Radioactive Waste Policy Act. Between 1982 and 1985, individuals in several of the states felt that coordination among the states would be beneficial to all by affording states a cost-effective method for sharing ideas, discussing alternatives, and presenting solutions to common problems. At the current time, the committee comprises members from each of the sited states. Various compacts, federal agencies, and industry groups participate in committee activities. The Low-Level Management Program provides support for the committee through the provision of logistical support and limited manpower allocation. Activities of the committee have recently focused on waste treatment and minimization technologies. The committee also has worked diligently to see the review of the 3RSTAT computer code completed. The committee has taken a position on various regulatory proposals the past year. The committee expects to continue its work until new sites are brought online.

  7. VIRTUE ETHICS - NEW COORDINATES FOR ECONOMIC DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    PUP ANCA

    2010-12-01

    Full Text Available Operating with business ethic we meet, some ethical systems, some of them developed in Antiquity, that still have a great influence upon economics development. One of these is the ethics of virtue. The aim of this paper work is to focus upon the one ethical system virtue ethics and to illustrate his influence in economical field, offering a new coordination in this direction. We understand the importance of the human character for a successful leadership and management. Recent ethical dilemmas illustrate us how a vicious character has an influence not only to the possessor of that type of character but also to the entire community where he develop his activities. For a comprehensive understanding I expose a briefly review on virtue ethics as it was developed by Plato and Aristotle, ant its new coordination and influence upon our contemporaneous economy, illustrated by some examples.

  8. Static analysis of large-scale multibody system using joint coordinates and spatial algebra operator.

    Science.gov (United States)

    Omar, Mohamed A

    2014-01-01

    Initial transient oscillations inhibited in the dynamic simulations responses of multibody systems can lead to inaccurate results, unrealistic load prediction, or simulation failure. These transients could result from incompatible initial conditions, initial constraints violation, and inadequate kinematic assembly. Performing static equilibrium analysis before the dynamic simulation can eliminate these transients and lead to stable simulation. Most exiting multibody formulations determine the static equilibrium position by minimizing the system potential energy. This paper presents a new general purpose approach for solving the static equilibrium in large-scale articulated multibody. The proposed approach introduces an energy drainage mechanism based on Baumgarte constraint stabilization approach to determine the static equilibrium position. The spatial algebra operator is used to express the kinematic and dynamic equations of the closed-loop multibody system. The proposed multibody system formulation utilizes the joint coordinates and modal elastic coordinates as the system generalized coordinates. The recursive nonlinear equations of motion are formulated using the Cartesian coordinates and the joint coordinates to form an augmented set of differential algebraic equations. Then system connectivity matrix is derived from the system topological relations and used to project the Cartesian quantities into the joint subspace leading to minimum set of differential equations. PMID:25045732

  9. FALCON: A method for flexible adaptation of local coordinates of nuclei.

    Science.gov (United States)

    König, Carolin; Hansen, Mads Bøttger; Godtliebsen, Ian H; Christiansen, Ove

    2016-02-21

    We present a flexible scheme for calculating vibrational rectilinear coordinates with well-defined strict locality on a certain set of atoms. Introducing a method for Flexible Adaption of Local COordinates of Nuclei (FALCON) we show how vibrational subspaces can be "grown" in an adaptive manner. Subspace Hessian matrices are set up and used to calculate and analyze vibrational modes and frequencies. FALCON coordinates can more generally be used to construct vibrational coordinates for describing local and (semi-local) interacting modes with desired features. For instance, spatially local vibrations can be approximately described as internal motion within only a group of atoms and delocalized modes can be approximately expressed as relative motions of rigid groups of atoms. The FALCON method can support efficiency in the calculation and analysis of vibrational coordinates and energies in the context of harmonic and anharmonic calculations. The features of this method are demonstrated on a few small molecules, i.e., formylglycine, coumarin, and dimethylether as well as for the amide-I band and low-frequency modes of alanine oligomers and alpha conotoxin. PMID:26896977

  10. Environmental benefits from hydro-thermal coordination

    International Nuclear Information System (INIS)

    Individual hydro- and thermal dominated electric power systems often have characteristics which make coordination between such systems inherently desirable. Operation- and design related differences call for interconnecting the two types of systems, e.g. by a 'pump-storage type' interplay between them. In this scheme the hydro-system can provide for required additional peak power and the necessary 'profiles' of production, while the thermal system covers new energy demand by increased energy production on the course of off-peak hours. Since energy represents one of the crucial building blocks in a modern society, all considerations concerning the development of coordinated systems of first of all focused on the functions and the economics efficiency of these systems and second on the technical solutions that have been developed. However, people have realized that they are part of a larger picture and that their well-being cannot be separated from that of nature. Power production from fossil burning and energy used can give about significant adverse environmental effects through emission into atmosphere of SO2, NOx, CO2, and particulates. The environmental aspects has more or less been neglected in the coordination process. Therefore the time in ripe to extend the discussion to include also environmental effects. The true least-cost solution to the utility operation- and planning problem can only be found by a consistent treatment of environmental effects in all steps of this problem. The paper gives an overview of the problem and demonstrates the environmental benefits from hydro-thermal coordination. (Author)

  11. The coordination chemistry of saturated molecules

    OpenAIRE

    Bercaw, John E.; Labinger, Jay A.

    2007-01-01

    Our understanding of bonding in transition metal complexes, as well as our ability to use that understanding in the synthesis and application of new species, has evolved over the last 100 years; and in some sense this special feature on the coordination chemistry of saturated molecules may be considered to represent its culmination. The nature of complexes between transition metal ions and neutral molecules such as ammonia was first correctly described by Werner around the beginning of the 20...

  12. Supply chain coordination in industrial symbiosis

    OpenAIRE

    Herczeg, Gabor; Akkerman, Renzo; Hauschild, Michael Zwicky

    2013-01-01

    Industrial symbiosis (IS) is a form of supply chain cooperation in industrial networks in order to achieve collective benefits by leveraging each other’s by-products and sharing services and utilities. This paper investigates the concept of IS from the perspective of supply chain coordination (SCC). For this purpose a theoretical framework is built based on SCC aspects, which is subsequently used to analyze a case study. We conclude that research is scant on operational issues and trade-offs ...

  13. Cylindrical Superlens by a Coordinate Transformation

    OpenAIRE

    Yan, Min; Yan, Wei; Qiu, Min

    2008-01-01

    Cylinder-shaped perfect lens deduced from the coordinate transformation method is proposed. The previously reported perfect slab lens is noticed to be a limiting form of the cylindrical lens when the inner radius approaches infinity with respect to the lens thickness. Connaturality between a cylindrical lens and a slab lens is affirmed by comparing their eigenfield transfer functions. We numerically confirm the subwavelength focusing capability of such a cylindrical lens with consideration of...

  14. Homomorphic Coordinates of Dempster’s Semigroup

    Czech Academy of Sciences Publication Activity Database

    Daniel, Milan

    Praha: Oeconomica, 2015 - (Kratochvíl, V.), s. 49-60 ISBN 978-80-245-2102-2. [WUPES 2015. Workshop on Uncertainty Processing /10./. Monínec (CZ), 16.09.2015-19.09.2015] Institutional support: RVO:67985807 Keywords : belief functions * Dempster-Shafer Theory * Dempster's semigroup * homomorphism * homomorphic coordinates Subject RIV: BA - General Mathematics http://wupes.fm.vse.cz/2015/data/Proceedings.pdf

  15. Coordination Techniques for Distributed Artificial Intelligence

    OpenAIRE

    Jennings, N. R.

    1996-01-01

    Coordination, the process by which an agent reasons about its local actions and the (anticipated) actions of others to try and ensure the community acts in a coherent manner, is perhaps the key problem of the discipline of Distributed Artificial Intelligence (DAI). In order to make advances it is important that the theories and principles which guide this central activity are uncovered and analysed in a systematic and rigourous manner. To this end, this paper models agent communities using a ...

  16. Coordination and Legitimacy in International Business Taxation.

    OpenAIRE

    Picciotto, Salomone

    2006-01-01

    This paper will outline the changing forms of cooperation between national tax authorities in the taxation of income or profits from international business, especially transnational corporations (TNCs). The case study will illustrate broader trends of transformation both of statehood and the international state system, from the classical liberal model based on interdependence and coordination of nation-states through central governments, towards a post-liberal one of decentred multi-level glo...

  17. Programmed device for coordinate measuring mechanisms

    International Nuclear Information System (INIS)

    The programmed device providing the automatic measurement of the coordinate of a continuously travelling carriage with stepwise control of the pitch and measurement range in wide limits is described. The matching of measured points at the direct and return travels of the carriage is within 50 mcm. The device was developed to automize the measurement of charged particles tracks by means of floating-wire method. It may be also used in different recorders

  18. Alternating Spatial Patterns for Coordinated Group Motion

    OpenAIRE

    Swain, Daniel T.; Leonard, Naomi Ehrich; Couzin, Iain D; Kao, Albert; Sepulchre, Rodolphe

    2007-01-01

    Abstract—Motivated by recent observations of fish schools, we study coordinated group motion for individuals with oscillatory speed. Neighbors that have speed oscillations with common frequency, amplitude and average but different phases, move together in alternating spatial patterns, taking turns being towards the front, sides and back of the group. We propose a model and control laws to investigate the connections between these spatial dynamics, communication when sensi...

  19. Coordination in Large-Scale Agile Development

    OpenAIRE

    Morken, Ragnar Alexander T

    2014-01-01

    In the last decade agile software development methods has become one of themost popular topics within software engineering. Agile software developmentis well accepted in small projects among the practitioner community and inrecent years, there has also been several large-scale projects adopting agilemethodologies, but there is little understanding of how such projects achieveeective coordination, which is known to be a critical factor in software engineering.This thesis describe an explorator...

  20. Spin Hall Effect in Noncommutative Coordinates

    OpenAIRE

    Dayi, O. F.; Elbistan, M.

    2008-01-01

    A semiclassical constrained Hamiltonian system which was established to study dynamical systems of matrix valued non-Abelian gauge fields is employed to formulate spin Hall effect in noncommuting coordinates at the first order in the constant noncommutativity parameter theta . The method is first illustrated by studying the Hall effect on the noncommutative plane in a gauge independent fashion. Then, the Drude model type and the Hall effect type formulations of spin Hall effect are considered...

  1. Towards reduction of Paradigm coordination models

    OpenAIRE

    Andova, S.; Groenewegen, L. P. J.; Vink, de, E.P.; Aceto, Luca; Mousavi, M.R.

    2011-01-01

    The coordination modelling language Paradigm addresses collaboration between components in terms of dynamic constraints. Within a Paradigm model, component dynamics are consistently specified at a detailed and a global level of abstraction. To enable automated verification of Paradigm models, a translation of Paradigm into process algebra has been defined in previous work. In this paper we investigate, guided by a client-server example, reduction of Paradigm models based on a notion of global...

  2. Price schedules coordination for electricity pool markets

    Science.gov (United States)

    Legbedji, Alexis Motto

    2002-04-01

    We consider the optimal coordination of a class of mathematical programs with equilibrium constraints, which is formally interpreted as a resource-allocation problem. Many decomposition techniques were proposed to circumvent the difficulty of solving large systems with limited computer resources. The considerable improvement in computer architecture has allowed the solution of large-scale problems with increasing speed. Consequently, interest in decomposition techniques has waned. Nonetheless, there is an important class of applications for which decomposition techniques will still be relevant, among others, distributed systems---the Internet, perhaps, being the most conspicuous example---and competitive economic systems. Conceptually, a competitive economic system is a collection of agents that have similar or different objectives while sharing the same system resources. In theory, constructing a large-scale mathematical program and solving it centrally, using currently available computing power can optimize such systems of agents. In practice, however, because agents are self-interested and not willing to reveal some sensitive corporate data, one cannot solve these kinds of coordination problems by simply maximizing the sum of agent's objective functions with respect to their constraints. An iterative price decomposition or Lagrangian dual method is considered best suited because it can operate with limited information. A price-directed strategy, however, can only work successfully when coordinating or equilibrium prices exist, which is not generally the case when a weak duality is unavoidable. Showing when such prices exist and how to compute them is the main subject of this thesis. Among our results, we show that, if the Lagrangian function of a primal program is additively separable, price schedules coordination may be attained. The prices are Lagrange multipliers, and are also the decision variables of a dual program. In addition, we propose a new form of

  3. Coordination mechanisms in the store opening process

    OpenAIRE

    Sandberg, Erik

    2014-01-01

    Purpose – For many retailers organic growth through the opening of new stores is a crucial cornerstone of the business model. The purpose of this paper is to explore the store opening process conducted by retail companies. The research questions cover: first, the role and organisation of the establishment function in charge of the process; second, the activities and functions involved in the process; and third, the coordination mechanisms applied during the process. Design/methodology/approac...

  4. Coordinating Expertise in Software Development Teams

    OpenAIRE

    Samer Faraj; Lee Sproull

    2000-01-01

    Like all teams, knowledge teams must acquire and manage critical resources in order to accomplish their work. The most critical resource for knowledge teams is expertise, or specialized skills and knowledge, but the mere presence of expertise on a team is insufficient to produce high-quality work. Expertise must be managed and coordinated in order to leverage its potential. That is, teams must be able to manage their skill and knowledge interdependencies effectively through expertise coordina...

  5. Locally inertial coordinates with totally antisymmetric torsion

    CERN Document Server

    Socolovsky, M

    2010-01-01

    We show that the necessary and sufficient condition for erecting locally inertial coordinates at a point $p$ of a $U^4$-space, and therefore assuring the validity of the equivalence principle at that point, is the vanishing at $p$ of the symmetric part of the contortion tensor. This fact does not demand a vanishing torsion, but only a totally antisymmetric one. As an application, we derive the geodesic deviation equation; and prove the compatibility with the Newtonian limit.

  6. The coordination dynamics of social neuromarkers

    OpenAIRE

    Emmanuelle Tognoli; Scott Kelso, J. A.

    2013-01-01

    Social behavior is a complex integrative function that entails many aspects of the brain’s sensory, cognitive, emotional and movement capacities. Its neural processes are seldom simultaneous but occur according to precise spatiotemporal choreographies, manifested by the coordination of their oscillations within and between brains. Methods with good temporal resolution can help to identify so-called “neuromarkers” of social function and aid in disentangling the dynamical architecture of social...

  7. Applications of chiroptical spectroscopy to coordination compounds

    Czech Academy of Sciences Publication Activity Database

    Wu, Tao; You, X. Z.; Bouř, Petr

    2015-01-01

    Roč. 284, SI (2015), s. 1-18. ISSN 0010-8545 R&D Projects: GA ČR GA13-03978S; GA ČR GAP208/11/0105 Grant ostatní: GA AV ČR(CZ) M200550902 Institutional support: RVO:61388963 Keywords : chirality * coordination compounds * chiroptical spectroscopy * new materials Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 12.239, year: 2014

  8. Coordination and communication inside game engine

    OpenAIRE

    Kukkamaa, T. (Tuomas)

    2015-01-01

    This study examines the communication and coordination among different parts of game engine. As games contain multiple co-operating processes, each of which handles a small part of whole game experience, game engines must handle the management of co-operation efficiently. The issue is that while the competitive and demanding game industry has hastened the development of game engines, the academic research has been lagging behind. This study aims to bridge the gap between industrial know-h...

  9. Coordinating, Scheduling, Processing and Analyzing IYA09

    Science.gov (United States)

    Gipson, John; Behrend, Dirk; Gordon, David; Himwich, Ed; MacMillan, Dan; Titus, Mike; Corey, Brian

    2010-01-01

    The IVS scheduled a special astrometric VLBI session for the International Year of Astronomy 2009 (IYA09) commemorating 400 years of optical astronomy and 40 years of VLBI. The IYA09 session is the most ambitious geodetic session to date in terms of network size, number of sources, and number of observations. We describe the process of designing, coordinating, scheduling, pre-session station checkout, correlating, and analyzing this session.

  10. Agents advanced features for negotiation and coordination

    OpenAIRE

    Oliveira, E.

    2001-01-01

    Agent-based systems suitable for dealing with applications where the environment is both dynamic and populated with competitors demand for sophisticated characteristics including adaptation, negotiation and coordination. We here briefly summarize some proposals on agents negotiation capabilities including adaptation through reinforcement learning as well as qualitative multi-criteria negotiation and coalition formation protocols. Also, and inspired by robosoccer domain, some basic hints on kn...

  11. TOURISME-TRANSPORT : CAPACITE DE COORDINATION

    OpenAIRE

    Marques, Bruno

    2016-01-01

    Two major findings emerge from the theoretical analysis of Transport-Tourism link via a game theory type model of capacity coordination. Firstly the model explains the optimal capacities ratio of Transport and Tourism by the quotient of the ratio of tourism type (ratio of the length of stay in the destination and of transport duration) divided by the installation costs ratio (of transport and tourism).The corollary of this first finding gives the second outcome: The optimal transport and Tour...

  12. TOURISME-TRANSPORT : CAPACITÉ DE COORDINATION

    OpenAIRE

    Marques, Bruno

    2016-01-01

    Two major findings emerge from the theoretical analysis of Transport-Tourism link via a game theory type model of capacity coordination. Firstly the model explains the optimal capacities ratio of Transport and Tourism by the quotient of the ratio of tourism type (ratio of the length of stay in the destination and of transport duration) divided by the installation costs ratio (of transport and tourism).The corollary of this first finding gives the second outcome: The optimal transport and Tour...

  13. Data Assimilation by delay-coordinate nudging

    Science.gov (United States)

    Pazo, Diego; Lopez, Juan Manuel; Carrassi, Alberto

    2016-04-01

    A new nudging method for data assimilation, delay-coordinate nudging, is presented. Delay-coordinate nudging makes explicit use of present and past observations in the formulation of the forcing driving the model evolution at each time-step. Numerical experiments with a low order chaotic system show that the new method systematically outperforms standard nudging in different model and observational scenarios, also when using an un-optimized formulation of the delay-nudging coefficients. A connection between the optimal delay and the dominant Lyapunov exponent of the dynamics is found based on heuristic arguments and is confirmed by the numerical results, providing a guideline for the practical implementation of the algorithm. Delay-coordinate nudging preserves the easiness of implementation, the intuitive functioning and the reduced computational cost of the standard nudging, making it a potential alternative especially in the field of seasonal-to-decadal predictions with large Earth system models that limit the use of more sophisticated data assimilation procedures.

  14. Promoting coordination in Norwegian health care

    Directory of Open Access Journals (Sweden)

    Tor I. Romøren

    2011-10-01

    Full Text Available   Introduction: The Norwegian health care system is well organized within its two main sectors - primary health and long term care on the one hand, and hospitals and specialist services on the other. However, the relation between them lacks mediating structures.Policy practice: Enhancing coordination between primary and secondary health care has been central in Norwegian health care policy the last decade. In 2003 a committee was appointed to identify coordination problems and proposed a lot of practical and organisational recommendations. It relied on an approach challenging primary and secondary health care in shared geographical regions to take action. However, these proposals were not implemented. In 2008 a new Minister of Health and Care worked out plans under the key term "Coordination Reform". These reform plans superseded and expanded the previous policy initiatives concerning cooperation, but represented also a shift in focus to a regulative and centralised strategy, including new health legislation, structural reforms and use of economic incentives that are now about to be implemented.Discussion: The article analyses the perspectives and proposals of the previous and the recent reform initiatives in Norway and discusses them in relation to integrated care measures implemented in Denmark and Sweden.

  15. Promoting coordination in Norwegian health care

    Directory of Open Access Journals (Sweden)

    Tor I. Romøren

    2011-10-01

    Full Text Available   Introduction: The Norwegian health care system is well organized within its two main sectors - primary health and long term care on the one hand, and hospitals and specialist services on the other. However, the relation between them lacks mediating structures. Policy practice: Enhancing coordination between primary and secondary health care has been central in Norwegian health care policy the last decade. In 2003 a committee was appointed to identify coordination problems and proposed a lot of practical and organisational recommendations. It relied on an approach challenging primary and secondary health care in shared geographical regions to take action. However, these proposals were not implemented. In 2008 a new Minister of Health and Care worked out plans under the key term "Coordination Reform". These reform plans superseded and expanded the previous policy initiatives concerning cooperation, but represented also a shift in focus to a regulative and centralised strategy, including new health legislation, structural reforms and use of economic incentives that are now about to be implemented. Discussion: The article analyses the perspectives and proposals of the previous and the recent reform initiatives in Norway and discusses them in relation to integrated care measures implemented in Denmark and Sweden.

  16. ITRF to GDA94 coordinate transformations

    Science.gov (United States)

    Dawson, John; Woods, Alex

    2010-12-01

    The Geocentric Datum of Australia 1994 (GDA94) is a static coordinate datum realised with respect to the International Terrestrial Reference Frame (ITRF) at the reference epoch of 1 January 1994. At this time GDA94 and ITRF were coincident, however, as a consequence of the tectonic motion of the Australian Plate, ongoing refinement of the ITRF and crustal deformation, the two reference frames have diverged and the absolute difference between them is now approximately 1 m. Consequently, precise coordinate transformations between ITRF and GDA94 are required for many applications, and in this study these transformations are reviewed, improved and extended. New transformation parameters between ITRF and GDA94 are computed, including the specific ITRF realisations of ITRF1996, ITRF1997, ITRF2000, ITRF2005 and ITRF2008. The two most recent ITRF realisations, ITRF2005 and ITRF2008, after transformation have a root-mean-square difference of less than 10 and 30 mm in the horizontal and vertical components, respectively, with respect to GDA94 at the Australian Fiducial Network (AFN) stations. However, the magnitude of some residuals exceed 15 and 60 mm in the horizontal and vertical components, respectively, which reflects the accuracy limit of GDA94. Finally, the implications and future strategies for managing the differences between GDA94 and ITRF are discussed, including novel coordinate transformation approaches and justifications for the modernisation of GDA.

  17. Nanometrization of Lanthanide-Based Coordination Polymers.

    Science.gov (United States)

    Neaime, Chrystelle; Daiguebonne, Carole; Calvez, Guillaume; Freslon, Stéphane; Bernot, Kevin; Grasset, Fabien; Cordier, Stéphane; Guillou, Olivier

    2015-11-23

    Heteronuclear lanthanide-based coordination polymers are microcrystalline powders, the luminescence properties of which can be precisely tuned by judicious choice of the rare-earth ions. In this study, we demonstrate that such materials can also be obtained as stable solutions of nanoparticles in non-toxic polyols. Bulk powders of the formula [Ln2-2x Ln'2x (bdc)3 ⋅4 H2 O]∞ (where H2 bdc denotes 1,4-benzene-dicarboxylic acid, 0≤x≤1, and Ln and Ln' denote lanthanide ions of the series La to Tm plus Y) afford nanoparticles that have been characterized by dynamic light-scattering (DLS) and transmission electron microscopy (TEM) measurements. Their luminescence properties are similar to those of the bulk materials. Stabilities versus time and versus dilution with another solvent have been studied. This study has revealed that it is possible to tune the size of the nanoparticles. This process offers a reliable means of synthesizing suspensions of nanoparticles with tunable luminescence properties and tunable size distributions in a green solvent (glycerol). The process is also extendable to other coordination polymers and other solvents (ethylene glycol, for example). It constitutes a new route for the facile solubilization of lanthanide-based coordination polymers. PMID:26471940

  18. Adaptive group coordination and role differentiation.

    Science.gov (United States)

    Roberts, Michael E; Goldstone, Robert L

    2011-01-01

    Many real world situations (potluck dinners, academic departments, sports teams, corporate divisions, committees, seminar classes, etc.) involve actors adjusting their contributions in order to achieve a mutually satisfactory group goal, a win-win result. However, the majority of human group research has involved situations where groups perform poorly because task constraints promote either individual maximization behavior or diffusion of responsibility, and even successful tasks generally involve the propagation of one correct solution through a group. Here we introduce a group task that requires complementary actions among participants in order to reach a shared goal. Without communication, group members submit numbers in an attempt to collectively sum to a randomly selected target number. After receiving group feedback, members adjust their submitted numbers until the target number is reached. For all groups, performance improves with task experience, and group reactivity decreases over rounds. Our empirical results provide evidence for adaptive coordination in human groups, and as the coordination costs increase with group size, large groups adapt through spontaneous role differentiation and self-consistency among members. We suggest several agent-based models with different rules for agent reactions, and we show that the empirical results are best fit by a flexible, adaptive agent strategy in which agents decrease their reactions when the group feedback changes. The task offers a simple experimental platform for studying the general problem of group coordination while maximizing group returns, and we distinguish the task from several games in behavioral game theory. PMID:21811595

  19. Adaptive group coordination and role differentiation.

    Directory of Open Access Journals (Sweden)

    Michael E Roberts

    Full Text Available Many real world situations (potluck dinners, academic departments, sports teams, corporate divisions, committees, seminar classes, etc. involve actors adjusting their contributions in order to achieve a mutually satisfactory group goal, a win-win result. However, the majority of human group research has involved situations where groups perform poorly because task constraints promote either individual maximization behavior or diffusion of responsibility, and even successful tasks generally involve the propagation of one correct solution through a group. Here we introduce a group task that requires complementary actions among participants in order to reach a shared goal. Without communication, group members submit numbers in an attempt to collectively sum to a randomly selected target number. After receiving group feedback, members adjust their submitted numbers until the target number is reached. For all groups, performance improves with task experience, and group reactivity decreases over rounds. Our empirical results provide evidence for adaptive coordination in human groups, and as the coordination costs increase with group size, large groups adapt through spontaneous role differentiation and self-consistency among members. We suggest several agent-based models with different rules for agent reactions, and we show that the empirical results are best fit by a flexible, adaptive agent strategy in which agents decrease their reactions when the group feedback changes. The task offers a simple experimental platform for studying the general problem of group coordination while maximizing group returns, and we distinguish the task from several games in behavioral game theory.

  20. Tools for Coordinating Planning Between Observatories

    Science.gov (United States)

    Jones, J.; Maks, L.; Fishman, M.; Grella, V.; Kerbel, U.; Misra, D.; Pell, V.

    With the realization of NASA's era of great observatories, there are now more than three space-based telescopes operating in different wave bands. This situation provides astronomers with a unique opportunity to simultaneously observe with multiple observatories. Yet scheduling multiple observatories simultaneously is highly inefficient when compared to observations using only a single observatory. Thus, programs using multiple observatories are limited not by scientific restrictions, but by operational inefficiencies. At present, multi-observatory programs are initiated by submitting observing proposals separately to each concerned observatory. To assure that the proposed observations can be scheduled, each observatory's staff has to check that the observations are valid and meet all constraints for their own observatory; in addition, they have to verify that the observations satisfy the constraints of the other observatories. Thus, coordinated observations require painstaking manual collaboration among staffs at each observatory. Due to the lack of automated tools for coordinated observations, this process is time consuming and error-prone, and the outcome of requests is not certain until the very end. To increase multi-observatory operations efficiency, such resource intensive processes need to be re-engineered. To overcome this critical deficiency, Goddard Space Flight Center's Advanced Architectures and Automation Branch is developing a prototype called the Visual Observation Layout Tool (VOLT). The main objective of VOLT is to provide visual tools to help automate the planning of coordinated observations by multiple astronomical observatories, as well as to increase the probability of scheduling all observations.

  1. Gains from Coordination in a Multisector Open Economy: Does It Pay to Be Different?

    OpenAIRE

    Zheng Liu; Evi Pappa

    2005-01-01

    Do countries gain by coordinating their monetary policies if they have different economic structures? We address this issue in the context of a new open-economy macro model with a traded and a non-traded sector and more importantly, with a cross-country asymmetry in the size of the traded sector. We study optimal monetary policy under independent and cooperating central banks, based on analytical expressions for welfare objectives derived from quadratic approximations to individual preference...

  2. Self-Gravitational Force Calculation of Second Order Accuracy for Infinitesimally Thin Gaseous Disks in Polar Coordinates

    CERN Document Server

    Wang, Hsiang-Hsu; Taam, Ronald E

    2015-01-01

    Investigating the evolution of disk galaxies and the dynamics of proto-stellar disks can involve the use of both a hydrodynamical and a Poisson solver. These systems are usually approximated as infinitesimally thin disks using two- dimensional Cartesian or polar coordinates. In Cartesian coordinates, the calcu- lations of the hydrodynamics and self-gravitational forces are relatively straight- forward for attaining second order accuracy. However, in polar coordinates, a second order calculation of self-gravitational forces is required for matching the second order accuracy of hydrodynamical schemes. We present a direct algorithm for calculating self-gravitational forces with second order accuracy without artifi- cial boundary conditions. The Poisson integral in polar coordinates is expressed in a convolution form and the corresponding numerical complexity is nearly lin- ear using a fast Fourier transform. Examples with analytic solutions are used to verify that the truncated error of this algorithm is of seco...

  3. The coordination of unprotonated peptide tertiary structure as a metric of pMHC-TCR functional avidity.

    Science.gov (United States)

    Antipas, Georgios S E; Germenis, Anastasios E

    2015-12-01

    The coordination difference between the unprotonated tertiary structures of a native (Tax) peptide and a number of its variants - all peptides presented by HLA-A201 and bound to the human A6 T cell receptor-was discovered to constitute a metric of pMHC-TCR functional avidity. Moreover, increasing coordination deviations from the index were found to flag correspondingly weakening immunological outcomes of the variant peptides. The prognostic utility of the coordination difference of unprotonated tertiary structure was established to operate strictly on the peptide scale, seizing to be of relevance either to the immediate peptide environment (i.e. within the realm of peptide short range order, within 7 Å of any peptide atom) or over the entirety of the pMHC-TCR complex. Additionally, the imprint of peptide immunological identity was expressed both by the total coordination as well as by its C-C partial. PMID:26568977

  4. The coordination of unprotonated peptide tertiary structure as a metric of pMHC–TCR functional avidity

    Directory of Open Access Journals (Sweden)

    Georgios S.E. Antipas

    2015-12-01

    Full Text Available The coordination difference between the unprotonated tertiary structures of a native (Tax peptide and a number of its variants – all peptides presented by HLA-A201 and bound to the human A6 T cell receptor-was discovered to constitute a metric of pMHC–TCR functional avidity. Moreover, increasing coordination deviations from the index were found to flag correspondingly weakening immunological outcomes of the variant peptides. The prognostic utility of the coordination difference of unprotonated tertiary structure was established to operate strictly on the peptide scale, seizing to be of relevance either to the immediate peptide environment (i.e. within the realm of peptide short range order, within 7 Å of any peptide atom or over the entirety of the pMHC–TCR complex. Additionally, the imprint of peptide immunological identity was expressed both by the total coordination as well as by its C–C partial.

  5. 77 FR 57638 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-09-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... new measures; Formal safety assessment; Piracy and armed robbery against ships; Implementation...

  6. 76 FR 19176 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2011-04-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct two... safety --Piracy and armed robbery against ships --Implementation of instruments and related...

  7. 75 FR 64390 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-10-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... --Formal safety assessment --Piracy and armed robbery against ships --General cargo ship...

  8. 78 FR 29201 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-05-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... new measures Formal safety assessment Piracy and armed robbery against ships Implementation...

  9. 77 FR 57637 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-09-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... --Protection of vital shipping lanes --Periodic review of administrative requirements in mandatory...

  10. 78 FR 58596 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-09-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... session of the Assembly --Protection of vital shipping lanes --Periodic review of...

  11. 77 FR 27832 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-05-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... Governing Board --Protection of vital shipping lanes --External relations: --Relations with the...

  12. 76 FR 30229 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2011-05-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct four... vital shipping lanes. --World Maritime University. --IMO International Maritime Law...

  13. Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon

    Directory of Open Access Journals (Sweden)

    Xu Rener

    2011-01-01

    Full Text Available Abstract Background ALPK1 (α-kinase 1 is a member of an unconventional alpha-kinase family, and its biological function remains largely unknown. Here we report the phenotypic characterization of one mutant line, in which the piggyBac (PB transposon is inserted into the Alpk1 gene. Results The piggyBac(PB insertion site in mutants was mapped to the first intron of the Alpk1 gene, resulting in the effective disruption of the intact Alpk1 transcript expression. The transposon-inserted Alpk1 homozygous mutants (Alpk1PB/PB displayed severe defects in motor coordination in a series of behavioral analysis, including dowel test, hanging wire test, rotarod analysis and footprint analysis. However, the cerebellar architecture, Purkinje cell morphology and electrophysiology of the Purkinje cells appeared normal in mutants. The motor coordination deficits in the Alpk1PB/PB mice were rescued by transgenic mice expressing the full-length Alpk1-coding sequence under the control of the ubiquitous expression promoter. Conclusions Our results indicate that ALPK1 plays an important role in the regulation of motor coordination. Alpk1PB/PB mice would be a useful model to provide a clue to the better understanding of the cellular and molecular mechanisms of ALPK1 in the control of fine motor activities.

  14. The horizontally homogeneous model equations of incompressible atmospheric flow in general orthogonal coordinates

    DEFF Research Database (Denmark)

    Jørgensen, Bo Hoffmann

    2003-01-01

    The goal of this brief report is to express the model equations for an incompressible flow which is horizontally homogeneous. It is intended as a computationally inexpensive starting point of a more complete solution for neutral atmospheric flow overcomplex terrain. This idea was set forth by...... equations is utilized expressing the flow variables in a transformed coordinate system in which they are horizontally homogeneous. The model utilizes the k - emodel with limited mixing length by Apsley and Castro (1997). This turbulence closure reflects the fact that the atmosphere is only neutral up to a...

  15. Investigations of the coordinates in Ptolemy's Geographike Hyphegesis Book 8

    OpenAIRE

    Marx, Christian

    2015-01-01

    In Book 8 of his Geographike Hyphegesis Ptolemy gives coordinates for ca. 360 so-called noteworthy cities. These coordinates are the time difference to Alexandria, the length of the longest day, and partly the ecliptic distance from the summer solstice. The supposable original conversions between the coordinates in Book 8 and the geographical coordinates in the location catalogue of Books 2-7 including the underlying parameters and tabulations are here reconstructed. The results document the ...

  16. Coordination of health care in the Nordic countries

    OpenAIRE

    Tor Iversen; Anders Anell; Unto Häkkinen; Christian Kronborg; Thorhildur Ólafsdóttir

    2016-01-01

    Coordination of health care exists at many different levels and in many different forms. We describe the similarities and differences in coordination mechanisms among the Nordic countries. In some respects, the Nordic countries approach coordination problems in similar ways although differences exist. The overall pattern shows that Finland and Sweden have less country-wide coordination compared with the other countries. There are many questions and few answers with regard to which mechanisms ...

  17. cultural differences in coordination decisions within interdependent security context

    OpenAIRE

    ju, linlin

    2009-01-01

    Abstract The purpose of this study is to investigate cultural differences in coordination decisions in a coordination game with considering IDS context. IDS context is introduced into a coordination game since it recently draws more and more people’s attention. The concepts of individualism/collectivism as the key aspects of culture variability are introduced into the cultural differences study. It is assumed that Chinese people are more collectivistic and more likely to coordinate each ot...

  18. Adaptive coordination in surgical teams: an interview study

    OpenAIRE

    Bogdanovic, Jasmina; Perry, Juliana; Guggenheim, Merlin; Manser, Tanja

    2015-01-01

    Background Effective teamwork has been recognised as a major contributor to safe patient care in surgery. Previous research has highlighted the importance of adaptive coordination for effective performance in acute care settings. Expanding this line of research this study explores the coordination behaviours and adaptive coordination strategies employed by surgical teams and identifies relevant situational characteristics influencing those coordination processes. Method We conducted a qualita...

  19. Iteration Complexity Analysis of Block Coordinate Descent Methods

    OpenAIRE

    Hong, Mingyi; Wang, Xiangfeng; Razaviyayn, Meisam; Luo, Zhi-Quan

    2013-01-01

    In this paper, we provide a unified iteration complexity analysis for a family of general block coordinate descent (BCD) methods, covering popular methods such as the block coordinate gradient descent (BCGD) and the block coordinate proximal gradient (BCPG), under various different coordinate update rules. We unify these algorithms under the so-called Block Successive Upper-bound Minimization (BSUM) framework, and show that for a broad class of multi-block nonsmooth convex problems, all algor...

  20. Coordination in Tree Adjoining Grammars: Formalization and Implementation

    OpenAIRE

    Sarkar, Anoop; Joshi, Aravind

    1996-01-01

    In this paper we show that an account for coordination can be constructed using the derivation structures in a lexicalized Tree Adjoining Grammar (LTAG). We present a notion of derivation in LTAGs that preserves the notion of fixed constituency in the LTAG lexicon while providing the flexibility needed for coordination phenomena. We also discuss the construction of a practical parser for LTAGs that can handle coordination including cases of non-constituent coordination.

  1. Proprioceptive bimanual test in intrinsic and extrinsic coordinates.

    Science.gov (United States)

    Iandolo, Riccardo; Squeri, Valentina; De Santis, Dalia; Giannoni, Psiche; Morasso, Pietro; Casadio, Maura

    2015-01-01

    Is there any difference between matching the position of the hands by asking the subjects to move them to the same spatial location or to mirror-symmetric locations with respect to the body midline? If the motion of the hands were planned in the extrinsic space, the mirror-symmetric task would imply an additional challenge, because we would need to flip the coordinates of the target on the other side of the workspace. Conversely, if the planning were done in intrinsic coordinates, in order to move both hands to the same spot in the workspace, we should compute different joint angles for each arm. Even if both representations were available to the subjects, the two tasks might lead to different results, providing some cue on the organization of the "body schema". In order to answer such questions, the middle fingertip of the non-dominant hand of a population of healthy subjects was passively moved by a manipulandum to 20 different target locations. Subjects matched these positions with the middle fingertip of their dominant hand. For most subjects, the matching accuracy was higher in the extrinsic modality both in terms of systematic error and variability, even for the target locations in which the configuration of the arms was the same for both modalities. This suggests that the matching performance of the subjects could be determined not only by proprioceptive information but also by the cognitive representation of the task: expressing the goal as reaching for the physical location of the hand in space is apparently more effective than requiring to match the proprioceptive representation of joint angles. PMID:25741268

  2. New Coordinates for the Evaporating Vaidya Black Hole

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jing-Yi; ZHAO Zheng

    2006-01-01

    @@ Drawbacks of the ingoing Eddington-Finkelstein coordinates in describing the quantum thermal properties of the evaporating Vaidya black hole are presented. A new coordinate system we proposed previously [Acta Phys.Sin. 46 (1997) 1273] is employed. In this new coordinate system, the thermal radiation temperature of the Vaidya black hole is discussed again with the back reaction method.

  3. Coordination compounds of transition metal chlorides with tetrazoles

    International Nuclear Information System (INIS)

    Coordination compounds (CC) of Co(2), Ni(2), Cu(2), Cd(2) chlorides with tetrazole and Ni(2) and Cd(2) chloride CC with tetrazolylhydrazone benzaldehyde are synthesized. The compounds are characterized by electron- and IR-spectroscopy, magnetic measurements (78-300 K), radiography. Conclusions are made on polynuclear structure of coordination compounds and Msup((2)) octahedron coordination

  4. 78 FR 32699 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-05-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... Secretary, Shipping Coordinating Committee, Department of State. BILLING CODE 4710-09-P...

  5. 75 FR 75532 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-12-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an.../imo . Dated: November 24, 2010. Jon Trent Warner, Executive Secretary, Shipping Coordinating...

  6. 77 FR 22057 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-04-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... Secretary, Shipping Coordinating Committee, Department of State. BILLING CODE 4710-09-P...

  7. 78 FR 17466 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-03-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an..., Executive Secretary, Shipping Coordinating Committee, Department of State. BILLING CODE 4710-09-P...

  8. 78 FR 48217 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2013-08-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an..., Executive Secretary, Shipping Coordinating Committee, Department of State. BILLING CODE 4710-09-P...

  9. 75 FR 27856 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2010-05-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an... Warner, Executive Secretary, Shipping Coordinating Committee, Department of State. BILLING CODE 4710-09-P...

  10. 77 FR 52106 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2012-08-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an..., Executive Secretary, Shipping Coordinating Committee, Department of State. BILLING CODE 4710-09-P...

  11. 76 FR 36613 - Shipping Coordinating Committee; Notice of Committee Meeting

    Science.gov (United States)

    2011-06-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Shipping Coordinating Committee; Notice of Committee Meeting The Shipping Coordinating Committee (SHC) will conduct an.../imo . Dated: June 14, 2011. Greg O'Brien, Shipping Coordinating Committee, Department of...

  12. How to achieve care coordination inside health care organizations

    DEFF Research Database (Denmark)

    Prætorius, Thim; C. Becker, Markus

    2015-01-01

    organization theory, where coordination is a central research topic. The article focuses on intra-organizational coordination, which is challenging especially across boundaries such as departments or professions. It provides an overview of the classic coordination mechanisms, e.g., standardization of work...

  13. 78 FR 37781 - Forest Resource Coordinating Committee; Meeting

    Science.gov (United States)

    2013-06-24

    ... Forest Service Forest Resource Coordinating Committee; Meeting AGENCY: Forest Service, USDA. ACTION... FURTHER INFORMATION CONTACT: Maya Solomon, Forest Resource Coordinating Committee Program Coordinator, 202... of June 6, 2013, in FR Doc. 2013-13453, on page 34035, in the first column, correct the...

  14. 7 CFR 227.35 - Responsibilities of State coordinator.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS NUTRITION EDUCATION AND TRAINING PROGRAM State Coordinator... implementation of the State Plan, (f) Coordination of the Program with the Child Nutrition Programs at the State and local levels, (g) Coordination of the Program with other nutrition education and......

  15. 22 CFR 94.8 - Interagency coordinating group.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Interagency coordinating group. 94.8 Section 94... § 94.8 Interagency coordinating group. The U.S. Central Authority shall nominate federal employees and may, from time to time, nominate private citizens to serve on an interagency coordinating group...

  16. Valuing the Leadership Role of University Unit Coordinators

    Science.gov (United States)

    Pepper, Coral; Roberts, Susan

    2016-01-01

    In this paper we describe the experiences of 64 unit coordinators across 15 Australian universities, gathered during 2011/2012 as part of an Office for Learning and Teaching (OLT) project. Our intention was to gain insight into how unit coordinators (academics who coordinate a discrete unit of study) perceive their role as leaders of learning in…

  17. Studying the cosmological apparent horizon with quasistatic coordinates

    Indian Academy of Sciences (India)

    Rui-Yan Yu; Towe Wang

    2013-02-01

    This article aims at a natural generalization of the static coordinates to the ( + 1)-dimensional Friedmann–Lemaître–Robertson–Walker (FLRW) Universe. After demonstrating a no-go theorem, we put forward the quasistatic coordinates for the FLRW Universe. Then, the quasistatic coordinates are utilized to study the unified first law and the scalar-type perturbations on the cosmological apparent horizon.

  18. Motivation Driven Multiagent Systems Coordination in Health Care

    OpenAIRE

    Zhang, Peng; Bai, Guohua

    2005-01-01

    This paper explores MultiAgent Systems coordination from a socio-psychological point of view. Activity Theory is introduced to explain the coordination among intelligent agents. The hierarchy and motivation thinking from Activity Theory is used to define the motivation driven MultiAgent Systems coordination mechanism. Finally, we apply this mechanism into a health care scenario.

  19. The handhold GPS in the coordinate conversion in of application

    International Nuclear Information System (INIS)

    The Handhold GPS whether in geological mapping, or in drilling layout, which has showed the simple and practical side, and it is convenient and quick in the coordinate conversion. This article introduced in the condition of the higher accuracy coordinate conversion parameters, with the superiority of using handhold GPS for the Gauss projection coordinate conversion. (author)

  20. Attentional Loads Associated with Interlimb Interactions Underlying Rhythmic Bimanual Coordination

    Science.gov (United States)

    Ridderikhoff, Arne; Peper, C. E.; Beek, Peter J.

    2008-01-01

    Studies of rhythmic bimanual coordination under dual-task conditions revealed (1) a dependence of secondary task performance on the stability of coordinative tasks, in that secondary task performance was better during in-phase than antiphase coordination, and (2) a shift in the mean relative phasing between the limbs compared to single-task…